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  1. Ländliche Entwicklung durch erneuerbare Energien - Das Beispiel Photovoltaik in Niederbayern

    NASA Astrophysics Data System (ADS)

    Zink, Roland

    2013-09-01

    Der Ausbau erneuerbarer Energien ist in Deutschland eine zentrale und politisch konsensfähige Forderung, um die Energieversorgung klimafreundlich und nachhaltig zu gestalten. Speziell ländliche Regionen rücken dabei in den Fokus, bieten sie doch aufgrund ihrer hohen Flächenverfügbarkeit große Potenziale für die flächenintensiven dezentralen Energieformen. Folglich erkennen Kommunen zunehmend das Entwicklungspotenzial dieser Technologien und sehen sie auch als Chance, neue wirtschaftliche Impulse vor Ort zu setzen. Der Beitrag skizziert die rasante Entwicklung der Photovoltaik im Regierungsbezirk Niederbayern und diskutiert anhand des Beispiels die Folgen für eine nachhaltige Regionalentwicklung.

  2. Das DNA-Puzzle

    NASA Astrophysics Data System (ADS)

    Kirchner, Stefan

    Im Jahre 1953 wurde von James Watson und Francis Crick erstmalig der strukturelle Aufbau der sogenannten DNA (Desoxyribonukleinsäure) beschrieben, welche das Erbgut jedes Lebewesens enthält. Der wesentliche Teil des Erbguts wird dabei durch eine sehr lange Folge der vier Basen Adenin (A), Cytosin (C), Guanin (G) und Thymin (T) codiert. Seit einigen Jahren ist es möglich, die Folge der vier Basen zu einer gegebenen DNA zu bestimmen. Biologen bezeichnen diesen Vorgang als Sequenzierung.

  3. Herausforderungen durch die deutsche Wiedervereinigung

    NASA Astrophysics Data System (ADS)

    Stäglin, Reiner

    Die Wiedervereinigung stellte auch die Statistik vor große Aufgaben. Die als Organ der staatlichen Planung staatsnah orientierte Statistik der DDR musste auf das zur Neutralität und wissenschaftlichen Unabhängigkeit verpflichtete System der Bundesrepublik umgestellt werden. Ebenso verlangten die Universitäten eine Neuorientierung. Die Deutsche Statistische Gesellschaft hat sich vor allem dreier Aufgaben mit großem Engagement, aber auch mit Bedachtsamkeit angenommen: Aufnahme und Integration der Statistiker aus den neuen Bundesländern in die Gesellschaft, Begleitung der Neuausrichtung des Faches Statistik an deren Hochschulen und Sicherung sowie Nutzung von Datenbeständen der ehemaligen DDR.

  4. DAS performance analysis

    SciTech Connect

    Bates, G.; Bodine, S.; Carroll, T.; Keller, M.

    1984-02-01

    This report begins with an overview of the Data Acquisition System (DAS), which supports several of PPPL's experimental devices. Performance measurements which were taken on DAS and the tools used to make them are then described.

  5. Unterstützung der IT-Service-Management-Prozesse an der Technischen Universität München durch eine Configuration-Management-Database

    NASA Astrophysics Data System (ADS)

    Knittl, Silvia

    Hochschulprozesse in Lehre und Verwaltung erfordern durch die steigende Integration und IT-Unterstützung ein sogenanntes Business Alignment der IT und damit auch ein professionelleres IT-Service-Management (ITSM). Die IT Infrastructure Library (ITIL) mit ihrer Beschreibung von in der Praxis bewährten Prozessen hat sich zum de-facto Standard im ITSM etabliert. Ein solcher Prozess ist das Konfigurationsmanagement. Es bildet die IT-Infrastruktur als Konfigurationselemente und deren Beziehungen in einem Werkzeug, genannt Configuration Management Database (CMDB), ab und unterstützt so das ITSM. Dieser Bericht beschreibt die Erfahrungen mit der prototypischen Einführung einer CMDB an der Technischen Universität München.

  6. Verbesserung der Prozessbedingungen beim Einlippentiefbohren durch unterschiedliche Formen der Vorschubmodulation

    NASA Astrophysics Data System (ADS)

    Eisseler, Rocco

    Das Tiefbohren mit Einlippenwerkzeugen ist bei vielen Anwendungen das Verfahren der ersten Wahl, vor allem wenn kleine und kleinste Bohrungsdurchmesser, ein sehr großes Verhältnis zwischen Bohrtiefe und Durchmesser (l/D) und eine hohe Bearbeitungsqualität gefordert werden. Der erreichbare Durchmesserbereich des Verfahrens liegt zwischen D = 0,5 mm und 40 mm, wobei die möglichen Bohrtiefen von l = 3 x D bis 250 x D reichen. Diese Werte beziehen sich auf das Vollbohren, beim Aufbohren können noch größere Durchmesser erreicht werden [1]. Die erreichbare Oberflächenqualität ist so hoch, dass in den meisten Fällen auf eine nachfolgende Feinbearbeitung verzichtet werden kann.

  7. Homo sapiens und das 21. Jahrhundert - evolutionsbiologische Betrachtungen

    NASA Astrophysics Data System (ADS)

    Oehler, Jochen

    Was meinen wir, wenn wir vom 21. Jahrhundert sprechen? Es ist ein Zeitraum, der sich durch die Festlegung des Menschen ergibt, die nach Christi Geburt verstrichene Zeit in Jahren zu zählen. Eine kulturelle Leistung, die primär auf der Fähigkeit beruht, das Phänomen Zeit a priori wahrnehmen zu können. Die Antizipation der Zeit ist in der Welt der Organismen ein weit verbreitetes Prinzip. Entsprechend existieren auf zellulären bis zu zentralnervösen Ebenen verschiedenste Mechanismen, die dies ermöglichen. So basiert die Zeitwahrnehmung des Menschen auf zentralnervösen Strukturen und Prozessen phylogenetisch älterer Hirnstrukturen, die ihrerseits die Körperfunktionen von der zellulären bis zur Verhaltensebene steuern und regeln und sie damit an exogene Zeitregime, wie z. B. den Tag-Nacht-Rhythmus (circadianer Rhythmus), anpassen. Die Chronobiologie weist nach, welch große adaptive Bedeutung zeitantizipierende Mechanismen für die Organismen haben, das heißt Fitness fördernd sind (Piechulla 1999; Spork 2004). Die für verschiedene Kulturen des Menschen maßgebliche Zeitrechnung basiert auf der quantitativen Erfassung kosmisch oder irdisch regelmäßig wiederkehrender Ereignisse.

  8. Das Märchen vom Zauberer im weißen Kittel: Mythen um berühmte Experimente und Experimentatoren

    NASA Astrophysics Data System (ADS)

    Hentschel, Klaus

    2003-09-01

    Um berühmte Experimentatoren und Experimente ranken sich ebenso Mythen wie um geniale Theoretiker. Sie sind in populärwissenschaftlichen Büchern, Lehrbüchern und sogar in wissenschaftshistorischen Texten verbreitet. Die durch die Aufklärung etablierte Kultur des eleganten Schauexperiments vermittelt ein schiefes Bild vom mühsamen Weg vieler Experimentatoren zum dargestellten Ergebnis. Auch der Mythos des einsamen, genialen Experimentators ohne Helfer widerspricht dem historischen Befund. Gleiches gilt für das experimentum crucis, das eine Theorie als entscheidendes Experiment belegen soll. Die historische Forschung zeigt, dass es eine lange, eigenständige Tradition der experimentellen und instrumentellen Arbeit gibt.

  9. Dioxin-ähnliche Wirkungen durch Grundwasser am Industriestandort Zeitz

    NASA Astrophysics Data System (ADS)

    Schirmer, Kristin; Bopp, Stephanie; Russold, Sandra; Popp, Peter

    Kurzfassung Im Rahmen der Etablierung des Standortes Zeitz (Sachsen-Anhalt) als Referenztestfeld zur Implementierung des Natural-Attenuation-Ansatzes, haben wir Grundwasser auf seine Fähigkeit untersucht, eine Dioxin-ähnliche Wirkung hervorzurufen. Die Dioxin-ähnliche Wirkung ist die Arylhydrocarbon Rezeptor-vermittelte Induktion des Proteinkomplexes Cytochrom CYP1A, welches als 7-Ethoxyresorufin-O-Deethylase (EROD) Enzymaktivität in einer Fischleberzelllinie gemessen wurde. Von 32 Probennahmestellen wiesen sieben eine signifikante EROD-Induktion auf, welche zu einem geringen Teil auf Polyzyklische Aromatische Kohlenwasserstoffe zurückzuführen war. Ein weiterer Teil der EROD-Induktion konnte den Substanzen Benzofuran, Indan und Inden zugesprochen werden, welche hier erstmalig als EROD-Induktoren identifiziert wurden. Alle Probennahmestellen mit signifikanter EROD-Induktion lagen im Anstrom bzw. westlich des früheren Standortes der Benzolanlage in Zeitz, was einen signifikanten Einfluss von Benzol vor allem auf den Transport und das Lösungsverhalten EROD-induzierender Grundwasserkontaminanten vermuten lässt. Insgesamt zeigen diese Untersuchungen, wie eine Kombination von chemischer und biologischer Analytik zu einer deutlich verbesserten Aussagekraft führt und somit zu einer nachhaltigen Überwachung der Qualität von Grundwasser beitragen kann. As part of setting up the test field Zeitz (Saxony-Anhalt, Germany) as a reference site for the implementation of Natural Attenuation as a remediation option, we have investigated groundwater for its ability to cause a dioxin-like response. The dioxin-like response is the aryl hydrocarbon receptor-mediated induction of the protein complex cytochrome CYP1A, which was measured as 7-Ethoxyresorufin-O-deethylase (EROD) enzyme activity in a fish liver cell line. Out of 32 sampling locations, seven showed significant EROD induction, which could be explained, to a minor extent, by the presence of polycyclic aromatic

  10. Connecting the Dots in DAS

    ERIC Educational Resources Information Center

    Ford, Tracy

    2012-01-01

    Many institutions implement a distributed antenna system (DAS) as part of a holistic approach to providing better wireless coverage and capacity on campus. A DAS provides wireless service within a particular area or structure via a network of separate antenna nodes that are connected to a common source through fiber or coaxial cable. Because DAS…

  11. Das mechatronische Fahrwerk der Zukunft

    NASA Astrophysics Data System (ADS)

    Rieth, Peter

    Technologiesprünge gab es immer wieder in der Geschichte der Automobiltechnologie, so auch in der Kraftfahrzeugbremse, die seit ihren Anfängen eine stete Weiterentwicklung erfahren hat (Bild 40-1). So erlangten schon mechanische Bremsen durchaus ein hohes Niveau, ehe die Hydraulik Mitte der zwanziger Jahre für Komfort und Sicherheit vollkommen neue Perspektiven eröffnete, welche durch Einführung der Hilfskraft(servo)bremsanlagen Mitte des letzten Jahrhunderts noch erweitert wurden. Den wichtigsten Technologiesprung, den der Kunde als Fortschritt erkennt und dementsprechend honoriert, ermöglichte die Elektronik Mitte der siebziger Jahre. ABS, ASR, EBV und nicht zuletzt ESC wären ohne sie nicht vorstellbar.

  12. Deutsch Durch Audio-Visuelle Methode: An Audio-Lingual-Oral Approach to the Teaching of German.

    ERIC Educational Resources Information Center

    Dickinson Public Schools, ND. Instructional Media Center.

    This teaching guide, designed to accompany Chilton's "Deutsch Durch Audio-Visuelle Methode" for German 1 and 2 in a three-year secondary school program, focuses major attention on the operational plan of the program and a student orientation unit. A section on teaching a unit discusses four phases: (1) presentation, (2) explanation, (3)…

  13. Umsetzung von CE-Prozessen durch neue Methoden und interaktive 3-D-Modelle

    NASA Astrophysics Data System (ADS)

    Lange, Andrea; Schulz, Torsten; Szymanski, Hans

    Innerhalb der EU gelten einheitliche Anforderungen an die Gestaltung von Maschinen, die in Form von grundlegenden Sicherheits- und Gesundheitsschutzanforderungen in der Maschinenrichtlinie (MaschRL) formuliert sind. Ihre Einhaltung dokumentiert der Hersteller mit der Konformitätserklärung und der Vergabe des CE-Zeichens. Die Maschinenrichtlinie ist ein Element des 1985 von der Europäischen Gemeinschaft (EG) beschriebenen "New Approach“ Rechtsetzungsmodells, das technologische Innovation ermöglicht und die Wettbewerbsfähigkeit der europäischen Industrie regelt. Es wurde erschaffen, um technische Handelshemmnisse im europäischen Binnenmarkt zu beseitigen und ein einheitliches Niveau hinsichtlich der Sicherheit der Produkte und dem Gesundheits- bzw. Verbraucherschutz zu gewährleisten. Alle Produkt-Richtlinien der EG, die später auf Grundlage des New Approach entstanden sind, weisen eine einheitliche Vorgehensweise auf, mit der diese Ziele erreicht werden sollen (VDI Verlag 11/2008).

  14. Dasty3, a WEB framework for DAS

    PubMed Central

    Villaveces, Jose M.; Jimenez, Rafael C.; Garcia, Leyla J.; Salazar, Gustavo A.; Gel, Bernat; Mulder, Nicola; Martin, Maria; Garcia, Alexander; Hermjakob, Henning

    2011-01-01

    Motivation: Dasty3 is a highly interactive and extensible Web-based framework. It provides a rich Application Programming Interface upon which it is possible to develop specialized clients capable of retrieving information from DAS sources as well as from data providers not using the DAS protocol. Dasty3 provides significant improvements on previous Web-based frameworks and is implemented using the 1.6 DAS specification. Availability: Dasty3 is an open-source tool freely available at http://www.ebi.ac.uk/dasty/ under the terms of the GNU General public license. Source and documentation can be found at http://code.google.com/p/dasty/. Contact: hhe@ebi.ac.uk PMID:21798964

  15. Physik gestern und heute Das Eiskalorimeter

    NASA Astrophysics Data System (ADS)

    Heering, P.

    2003-07-01

    Kalorimetrische Messungen gehören heute zum experimentellen Standardrepertoire im Bereich der Thermodynamik und der physikalischen Chemie. Das erste Gerät für derartige Messungen entwickelten Ende des 18. Jahrhunderts die französischen Wissenschaftler Antoine Laurent Lavoisier und Pierre Simon de Laplace.

  16. GHRSST-14 DAS-TAG Report

    NASA Technical Reports Server (NTRS)

    Armstrong, Edward; Piolle, Jean Francois

    2013-01-01

    The DAS-TAG provides the informatics and data management expertise in emerging information technologies for the GHRSST community. It provides expertise in data and metadata formats and standards, fosters improvements for GHRSST data curation, experiments with new data processing paradigms, and evaluates services and tools for data usage. It provides a forum for producer and distributor data management issues and coordination.

  17. Moisture Forecast Bias Correction in GEOS DAS

    NASA Technical Reports Server (NTRS)

    Dee, D.

    1999-01-01

    Data assimilation methods rely on numerous assumptions about the errors involved in measuring and forecasting atmospheric fields. One of the more disturbing of these is that short-term model forecasts are assumed to be unbiased. In case of atmospheric moisture, for example, observational evidence shows that the systematic component of errors in forecasts and analyses is often of the same order of magnitude as the random component. we have implemented a sequential algorithm for estimating forecast moisture bias from rawinsonde data in the Goddard Earth Observing System Data Assimilation System (GEOS DAS). The algorithm is designed to remove the systematic component of analysis errors and can be easily incorporated in an existing statistical data assimilation system. We will present results of initial experiments that show a significant reduction of bias in the GEOS DAS moisture analyses.

  18. Das morgendliche Brückenritual

    NASA Astrophysics Data System (ADS)

    Sander, Oliver

    Es wäre für Mediziner sehr interessant zu wissen, was für Kräfte genau in den menschlichen Knien wirken. Klar ist, dass sie recht groß sein müssen. Das Gewicht eines erwachsenen Mannes beträgt ca. 80 kg. Wenn davon je die Hälfte auf einem Bein ruht hat man schon mindestens 400 Newton pro Knie, beim Laufen, Springen, oder Treppensteigen noch viel mehr. Man will es aber noch viel genauer wissen. Die Kondylen, das sind die Kontaktflächen in den Knien, sind nicht eben. Es gibt dort Unregelmäßigkeiten, und die Kräfte konzentrieren sich dort. An einzelnen Stellen können die Kräfte dann noch viel höher sein.

  19. "Das Konkrete ist das Abstrakte, an das man sich schließlich gewöhnt hat." (Laurent Schwartz) Über den Ablauf des mathematischen Verstehens

    NASA Astrophysics Data System (ADS)

    Lowsky, Martin

    Die im Titel genannte Aussage findet sich in den Lebenserinnerungen von Laurent Schwartz (1915-2002), einem der fruchtbarsten Mathematiker, Mitglied der Gruppe Bourbaki. Im Original lautet die Aussage: "un objet concret est un objet abstrait auquel on a fini par s'habituer." Schwartz erläutert sie am Beispiel des Integrals über {e^{-1/2{x^2}}} , das den Wert Wurzel aus 2π hat und in dem sich also die Zahlen e und π verknüpfen. Was Schwartz aber vor allem ausdrücken will, ist dies: Das mathematische Verständnisd geht langsam vor sich und es bedarf der Anstrengung. "Es ist eine Frage der Zeit und der Energie", sagt Schwartz, und gerade dies mache es so schwer, die höhere Mathematik unter das Volk zu bringen. Das Lernen und Lehren von Mathematik laufe eben mühevoll und langsam ab.

  20. Pedagogical Basis of DAS Formalism in Engineering Education

    ERIC Educational Resources Information Center

    Hiltunen, J.; Heikkinen, E.-P.; Jaako, J.; Ahola, J.

    2011-01-01

    The paper presents a new approach for a bachelor-level curriculum structure in engineering. The approach is called DAS formalism according to its three phases: description, analysis and synthesis. Although developed specifically for process and environmental engineering, DAS formalism has a generic nature and it could also be used in other…

  1. DAS: A Data Management System for Instrument Tests and Operations

    NASA Astrophysics Data System (ADS)

    Frailis, M.; Sartor, S.; Zacchei, A.; Lodi, M.; Cirami, R.; Pasian, F.; Trifoglio, M.; Bulgarelli, A.; Gianotti, F.; Franceschi, E.; Nicastro, L.; Conforti, V.; Zoli, A.; Smart, R.; Morbidelli, R.; Dadina, M.

    2014-05-01

    The Data Access System (DAS) is a and data management software system, providing a reusable solution for the storage of data acquired both from telescopes and auxiliary data sources during the instrument development phases and operations. It is part of the Customizable Instrument WorkStation system (CIWS-FW), a framework for the storage, processing and quick-look at the data acquired from scientific instruments. The DAS provides a data access layer mainly targeted to software applications: quick-look displays, pre-processing pipelines and scientific workflows. It is logically organized in three main components: an intuitive and compact Data Definition Language (DAS DDL) in XML format, aimed for user-defined data types; an Application Programming Interface (DAS API), automatically adding classes and methods supporting the DDL data types, and providing an object-oriented query language; a data management component, which maps the metadata of the DDL data types in a relational Data Base Management System (DBMS), and stores the data in a shared (network) file system. With the DAS DDL, developers define the data model for a particular project, specifying for each data type the metadata attributes, the data format and layout (if applicable), and named references to related or aggregated data types. Together with the DDL user-defined data types, the DAS API acts as the only interface to store, query and retrieve the metadata and data in the DAS system, providing both an abstract interface and a data model specific one in C, C++ and Python. The mapping of metadata in the back-end database is automatic and supports several relational DBMSs, including MySQL, Oracle and PostgreSQL.

  2. Das Lektin aus der Erbse Pisum sativum : Bindungsstudien, Monomer-Dimer-Gleichgewicht und Rückfaltung aus Fragmenten

    NASA Astrophysics Data System (ADS)

    Küster, Frank

    2002-11-01

    Das Lektin aus Pisum sativum, der Gartenerbse, ist Teil der Familie der Leguminosenlektine. Diese Proteine haben untereinander eine hohe Sequenzhomologie, und die Struktur ihrer Monomere, ein all-ß-Motiv, ist hoch konserviert. Dagegen gibt es innerhalb der Familie eine große Vielfalt an unterschiedlichen Quartärstrukturen, die Gegenstand kristallographischer und theoretischer Arbeiten waren. Das Erbsenlektin ist ein dimeres Leguminosenlektin mit einer Besonderheit in seiner Struktur: Nach der Faltung in der Zelle wird aus einem Loop eine kurze Aminosäuresequenz herausgeschnitten, so dass sich in jeder Untereinheit zwei unabhängige Polypeptidketten befinden. Beide Ketten sind aber stark miteinander verschränkt und bilden eine gemeinsame strukturelle Domäne. Wie alle Lektine bindet Erbsenlektin komplexe Oligosaccharide, doch sind seine physiologische Rolle und der natürliche Ligand unbekannt. In dieser Arbeit wurden Versuche zur Entwicklung eines Funktionstests für Erbsenlektin durchgeführt und seine Faltung, Stabilität und Monomer-Dimer-Gleichgewicht charakterisiert. Um die spezifische Rolle der Prozessierung für Stabilität und Faltung zu untersuchen, wurde ein unprozessiertes Konstrukt in E. coli exprimiert und mit der prozessierten Form verglichen. Beide Proteine zeigen die gleiche kinetische Stabilität gegenüber chemischer Denaturierung. Sie denaturieren extrem langsam, weil nur die isolierten Untereinheiten entfalten können und das Monomer-Dimer-Gleichgewicht bei mittleren Konzentrationen an Denaturierungsmittel auf der Seite der Dimere liegt. Durch die extrem langsame Entfaltung zeigen beide Proteine eine apparente Hysterese im Gleichgewichtsübergang, und es ist nicht möglich, die thermodynamische Stabilität zu bestimmen. Die Stabilität und die Geschwindigkeit der Assoziation und Dissoziation in die prozessierten bzw. nichtprozessierten Untereinheiten sind für beide Proteine gleich. Darüber hinaus konnte gezeigt werden, dass auch unter

  3. Pedagogical basis of DAS formalism in engineering education

    NASA Astrophysics Data System (ADS)

    Hiltunen, J.; Heikkinen, E.-P.; Jaako, J.; Ahola, J.

    2011-03-01

    The paper presents a new approach for a bachelor-level curriculum structure in engineering. The approach is called DAS formalism according to its three phases: description, analysis and synthesis. Although developed specifically for process and environmental engineering, DAS formalism has a generic nature and it could also be used in other engineering fields. The motivation for this new curriculum structure originates from the urge to solve the problems that engineering education has faced during the past decades, e.g. student recruitment problems and dissatisfactory learning outcomes. The focus of this paper is on the structure of the curriculum but the content is also discussed when it has an effect on the structure and its implementation. The presented structure, i.e. DAS formalism, builds upon the ideas of some classical pedagogical theories, which have regularly been applied at course level but seldom used to solve curriculum-level issues.

  4. Was hat das Universum mit uns zu tun?

    NASA Astrophysics Data System (ADS)

    Lesch, Harald

    Was hat das Universum mit uns zu tun? Da der Mensch ein Teil des Universums ist, muss er etwas mit dem Universum zu tun haben. Das Universum stellt ja ganz allgemein den größten Ursache-Wirkung-Zusammenhang dar, über den hinaus zwar noch gedacht und gerechnet, aber nichts mehr beobachtet oder gemessen werden kann. Es definiert also nicht nur die Möglichkeiten materiell-energetischer Seinsformen sondern auch deren Grenzen. Leben, bzw. menschliches Leben stellt im Universum dann zwar eine spezielle Form, aber eben nur eine Form materieller Daseinsstruktur dar. Neben Galaxien, Gas, Sternen, Planeten, Asteroiden und anderen Formen unbelebter Materie gibt es eben auch noch Lebewesen. Das klingt nach Inventur, nach Aufzählung ohne Unterschied. Diese einfache erste Betrachtung liefert vielleicht die ein oder andere Anregung für ein weiteres Suchen nach Substanzen, aber ein wesentliches Moment geht hier verloren. Ich meine die empirische, sehr gut abgesicherte Tatsache, dass das Universum, wie alles was es enthält, eine Entwicklung durchlaufen hat und auch weiterhin durchläuft - nennen wir diese Entwicklung die kosmische Evolution.

  5. Phenotypic and genotypic characterization of influenza virus mutants selected with the sialidase fusion protein DAS181

    PubMed Central

    Triana-Baltzer, Gallen B.; Sanders, Rebecca L.; Hedlund, Maria; Jensen, Kellie A.; Aschenbrenner, Laura M.; Larson, Jeffrey L.; Fang, Fang

    2011-01-01

    Background Influenza viruses (IFVs) frequently achieve resistance to antiviral drugs, necessitating the development of compounds with novel mechanisms of action. DAS181 (Fludase®), a sialidase fusion protein, may have a reduced potential for generating drug resistance due to its novel host-targeting mechanism of action. Methods IFV strains B/Maryland/1/59 and A/Victoria/3/75 (H3N2) were subjected to >30 passages under increasing selective pressure with DAS181. The DAS181-selected IFV isolates were characterized in vitro and in mice. Results Despite extensive passaging, DAS181-selected viruses exhibited a very low level of resistance to DAS181, which ranged between 3- and 18-fold increase in EC50. DAS181-selected viruses displayed an attenuated phenotype in vitro, as exhibited by slower growth, smaller plaque size and increased particle to pfu ratios relative to wild-type virus. Further, the DAS181 resistance phenotype was unstable and was substantially reversed over time upon DAS181 withdrawal. In mice, the DAS181-selected viruses exhibited no greater virulence than their wild-type counterparts. Genotypic and phenotypic analysis of DAS181-selected viruses revealed mutations in the haemagglutinin (HA) and neuraminidase (NA) molecules and also changes in HA and NA function. Conclusions Results indicate that resistance to DAS181 is minimal and unstable. The DAS181-selected IFV isolates exhibit reduced fitness in vitro, likely due to altered HA and NA functions. PMID:21097900

  6. Das menschliche Gehör und Grundlagen der Psychoakustik

    NASA Astrophysics Data System (ADS)

    Genuit, Klaus; Sottek, Roland

    Das menschliche Gehör ist ein äußerst komplexes Empfangs- und Signalverarbeitungssystem. Es ist als Schallanalysator in Leistungsfähigkeit und Vielseitigkeit von technisch-analytischen Verfahren nach wie vor unerreicht. Die Signalverarbeitung läuft auf Grundlage komplexer Prozesse ab, die in ihrer Gesamtheit bislang nicht vollständig erfasst sind. Verschiedene Modelle zur gehörgerechten Zeit- und Frequenzanalyse ahmen jene komplexen Prozesse und Verarbeitungsmechanismen nach, die im menschlichen Gehör vollzogen werden.

  7. Discrepancies in assessment of patients with rheumatoid arthritis and secondary Sjögren's syndrome by DAS28-ESR and DAS28-CRP

    PubMed Central

    Olesińska, Marzena; Paradowska-Gorycka, Agnieszka; Mańczak, Małgorzata; Felis-Giemza, Anna; Wojdasiewicz, Piotr; Szukiewicz, Dariusz

    2016-01-01

    Objectives To investigate whether a difference exists between DAS28 from CRP and DAS28 from ESR in patients with rheumatoid arthritis (RA) and secondary Sjögren's syndrome (sSS). Material and methods One group comprised patients with RA and sSS, the control group comprised patients with RA. The inclusion criteria for the RA and sSS group have been specified as follows: presence of at least one symptom of dryness, and also presence of anti-SS-A and anti-SS-B or at least focus score of one in biopsy. Results The disease activity score 28 (DAS28) was assessed using both ESR and CRP in 60 patients with RA and sSS and 59 patients with RA alone. However, concordance between these two methods was good (Cohen's κ coefficient κ = 0.60, 95% CI: 0.45-0.75 in the first group and κ = 0.71, 95% CI: 0.56-0.86 in the control group). In the group with RA and sSS, the mean value of DAS28-ESR = 5.2, whereas the mean value of DAS28-CRP = 4.7 (p < 0.0001). In the group with RA alone, mean DAS28-ESR = 4.7 while mean DAS28-CRP = 4.6; no significant difference was identified. Moreover, in RA patients with sSS, mean ESR = 39 mm/h compared with mean CRP at 25 mg/l. 79% of all patients demonstrated dysproteinaemia. There were connections between higher ESR and dysproteinaemia. In the control group there was no statistically significant difference between CRP and ESR. Conclusions Both DAS28-ESR and DAS28-CRP are useful outcome measures in RA. However, in patients with RA and sSS, DAS28 should be evaluated based on CRP. PMID:27536205

  8. Einfluss des Internets auf das Informations-, Einkaufs- und Verkehrsverhalten

    NASA Astrophysics Data System (ADS)

    Nerlich, Mark R.; Schiffner, Felix; Vogt, Walter

    Mit Daten aus eigenen Erhebungen können das einkaufsbezogene Informations- und Einkaufsverhalten im Zusammenhang mit den verkehrlichen Aspekten (Distanzen, Verkehrsmittel, Wegekopplungen) dargestellt werden. Die Differenzierung in die drei Produktkategorien des täglichen, mittelfristigen und des langfristigen Bedarfs berücksichtigt in erster Linie die Wertigkeit eines Gutes, die seine Erwerbshäufigkeit unmittelbar bestimmt. Der Einsatz moderner IKT wie das Internet eröffnet dem Endverbraucher neue Möglichkeiten bei Information und Einkauf. Die verkehrliche Relevanz von Online-Shopping wird deutlich, wenn man berücksichtigt, dass im Mittel rund 17% aller Online-Einkäufe, die die Probanden durchgeführt haben, Einkäufe in Ladengeschäften ersetzen. Dies gilt in verstärktem Maße für Online-Informationen: etwa die Hälfte hätte alternativ im stationären Einzelhandel stattgefunden. Da der Erwerb von Gütern des täglichen Bedarfs häufig nahräumlich und in relevantem Anteil nicht-motorisiert erfolgen kann, sind in diesem Segment - im Gegensatz zum mittel- und langfristigen Bedarf - nur geringe Substitutionseffekte zu beobachten.

  9. Statistical Quality Control of Moisture Data in GEOS DAS

    NASA Technical Reports Server (NTRS)

    Dee, D. P.; Rukhovets, L.; Todling, R.

    1999-01-01

    A new statistical quality control algorithm was recently implemented in the Goddard Earth Observing System Data Assimilation System (GEOS DAS). The final step in the algorithm consists of an adaptive buddy check that either accepts or rejects outlier observations based on a local statistical analysis of nearby data. A basic assumption in any such test is that the observed field is spatially coherent, in the sense that nearby data can be expected to confirm each other. However, the buddy check resulted in excessive rejection of moisture data, especially during the Northern Hemisphere summer. The analysis moisture variable in GEOS DAS is water vapor mixing ratio. Observational evidence shows that the distribution of mixing ratio errors is far from normal. Furthermore, spatial correlations among mixing ratio errors are highly anisotropic and difficult to identify. Both factors contribute to the poor performance of the statistical quality control algorithm. To alleviate the problem, we applied the buddy check to relative humidity data instead. This variable explicitly depends on temperature and therefore exhibits a much greater spatial coherence. As a result, reject rates of moisture data are much more reasonable and homogeneous in time and space.

  10. M-DAS: System for multispectral data analysis. [in Saginaw Bay, Michigan

    NASA Technical Reports Server (NTRS)

    Johnson, R. H.

    1975-01-01

    M-DAS is a ground data processing system designed for analysis of multispectral data. M-DAS operates on multispectral data from LANDSAT, S-192, M2S and other sources in CCT form. Interactive training by operator-investigators using a variable cursor on a color display was used to derive optimum processing coefficients and data on cluster separability. An advanced multivariate normal-maximum likelihood processing algorithm was used to produce output in various formats: color-coded film images, geometrically corrected map overlays, moving displays of scene sections, coverage tabulations and categorized CCTs. The analysis procedure for M-DAS involves three phases: (1) screening and training, (2) analysis of training data to compute performance predictions and processing coefficients, and (3) processing of multichannel input data into categorized results. Typical M-DAS applications involve iteration between each of these phases. A series of photographs of the M-DAS display are used to illustrate M-DAS operation.

  11. Psychometric Properties of the Disability Assessment Schedule (DAS) for Behavior Problems: An Independent Investigation

    ERIC Educational Resources Information Center

    Tsakanikos, Elias; Underwood, Lisa; Sturmey, Peter; Bouras, Nick; McCarthy, Jane

    2011-01-01

    The present study employed the Disability Assessment Schedule (DAS) to assess problem behaviors in a large sample of adults with ID (N = 568) and evaluate the psychometric properties of this instrument. Although the DAS problem behaviors were found to be internally consistent (Cronbach's [alpha] = 0.87), item analysis revealed one weak item…

  12. Das Programm Oder 2006. Hochwasserschutz in Polen im Zuge der EU-Osterweiterung

    NASA Astrophysics Data System (ADS)

    Kühne, Olaf

    Hochwasser ist ein natürliches Ereignis: Seit jeher sind die Menschen mit Hochwasser und seinen Auswirkungen konfrontiert. Das Ausmaß von Hochwasser reicht dabei von Straßenüberschwemmungen bis zur Überflutung ganzer Landesteile. Auch im Oderflußsystem waren und sind Überschwemmungen keine Seltenheit, in den letzten 200 Jahren ereigneten sie sich in den Jahren 1813, 1838, 1854, 1870, 1903, 1958, 1965, 1970, 1972, 1977, 1981, 1985 und 1997. Das Hochwasser von 1997 war jedoch das schwerste im genannten Zeitraum. Als Reaktion auf das Hochwasser von 1997 wurde in der betroffenen Region das Programm 〝Oder 2006`` entwickelt. Mit seiner Hilfe sollen die Auswirkungen künftiger Hochwasserereignisse abgeschwächt werden.

  13. Development of Ga-67 labeled DFO-DAS-fibrinogen conjugate as a thrombus imaging agent.

    PubMed

    Yamaoka, S

    1987-01-01

    A cluster method developed for labeling large molecular proteins with radioactive metal was applied for 67Ga-labeled fibrinogen. A large number of deferoxamine (DFO) was introduced to human fibrinogen using dialdehyde strarch (DAS) as a spacer-functional polymer. The synthesized DFO-DAS-fibrinogen mentioned above was easily labeled with GaCl3 (67Ga) solution (2 mCi/5 mg). The basic investigations found that 67Ga-DFO-DAS-fibrinogen was applicable to the diagnosis of thrombus, and clinical trials were carried out under the physician-sponsored IND. In our further investigation, improvement of the 67Ga-DFO-DAS-fibrinogen reagent was attempted to obtain high specific radioactivity. This was accomplished with the more familiar 67Ga citrate. From the results of a series of experiments, 67Ga-DFO-DAS-fibrinogen of a new composition labeled using 67Ga citrate with high specific radioactivity (2 mCi/3 mg) was prepared, and both reagents were evaluated as thrombus imaging agents from the chemical and biological aspects. The labeling efficiency and clottability of both 67Ga-DFO-DAS-fibrinogen conjugates were satisfactorily high, more than 95% and 80%, respectively. The biodistribution in rats showed that both 67Ga-DFO-DAS-fibrinogen conjugates were essentially the same. These results suggest that there are no significant differences between reagents. At present, the improved reagents are being supplied for the second clinical trials under physician-sponsored IND. PMID:3438481

  14. Crosslinking effect of dialdehyde starch (DAS) on decellularized porcine aortas for tissue engineering.

    PubMed

    Wang, Xu; Gu, Zhipeng; Qin, Huanhuan; Li, Li; Yang, Xu; Yu, Xixun

    2015-08-01

    Biological tissue-derived biomaterials must be chemically modified to avoid immediate degradation and immune response before being implanted in human body to replace malfunctioning organs. DAS with active aldehyde groups was employed to replace glutaraldehyde (GA), a most common synthetic crosslinking reagent in clinical practice, to fix bioprostheses for lower cytotoxicity. The aim of this research was to evaluate fixation effect of DAS. The tensile strength, crosslinking stability, cytotoxicity especially the anti-calcification capability of DAS-fixed tissues were investigated. The tensile strength and resistance to enzymatic degradation of samples were increased after DAS fixation, the values maintained stably in D-Hanks solution for several days. Meanwhile, ultrastructure of samples preserved well and the anti-calcification capability of samples were improved, the amount of positive staining points in the whole visual field of 15% DAS-fixed samples was only 0.576 times to GA-fixed ones. Moreover, both unreacted DAS and its hydrolytic products were nontoxic in cytotoxicity study. The results demonstrated DAS might be an effective crosslinking reagent to fix biological tissue-derived biomaterials in tissue engineering. PMID:26038106

  15. Das AL-Konzept: Ein Konzept für Bearbeitungszentren zur Großserienfertigung

    NASA Astrophysics Data System (ADS)

    Müllner, Ralf

    In der Großserienfertigung hält der Trend weg von Transferstraßen und Rundtaktmaschinen nun schon mehrere Jahre ungebrochen an. Vielfach wurden diese klassischen Einrichtungen zur Produktion hoher Stückzahlen inzwischen durch Fertigungsanlagen, wie z.B. Fertigungsmodule oder mehrspindlige Bearbeitungszentren ersetzt. Die Motivation hierzu ist vielschichtig. Eine ständig zunehmende Variantenanzahl der zu fertigenden Teile neben einem oft sehr unterschiedlichen Stückzahlbedarf begründet den Wunsch nach kleineren flexiblen Einheiten für die Fertigung. Um während der Produktionsphase eines Bauteils auf Stückzahlschwankungen reagieren zu können wird zudem eine bessere Skalierbarkeit gefordert, als es Transferstraßen und Rundtaktmaschinen ermöglichen.

  16. A Safety Evaluation of DAS181, a Sialidase Fusion Protein, in Rodents

    PubMed Central

    Larson, Jeffrey L.; Kang, Seong-Kwi; Choi, Bo In; Hedlund, Maria; Aschenbrenner, Laura M.; Cecil, Beth; Machado, GloriaMay; Nieder, Matthew; Fang, Fang

    2011-01-01

    DAS181 is a novel inhaled drug candidate blocking influenza virus (IFV) and parainfluenza virus (PIV) infections through removal of sialic acid receptors from epithelial surface of the respiratory tract. To support clinical development, a 28-day Good Laboratory Practices inhalation toxicology study was conducted in Sprague-Dawley rats. In this study, achieved average daily doses based on exposure concentrations were 0.47, 0.90, 1.55, and 3.00 mg/kg/day of DAS181 in a dry powder formulation. DAS181 was well tolerated at all dose levels, and there were no significant toxicological findings. DAS181 administration did not affect animal body weight, food consumption, clinical signs, ophthalmology, respiratory parameters, or organ weight. Gross pathology evaluations were unremarkable. Histological examination of the lungs was devoid of pulmonary tissue damage, and findings were limited to mild and transient changes indicative of exposure and clearance of a foreign protein. DAS181 did not show any cytotoxic effects on human and animal primary cells, including hepatocytes, skeletal muscle cells, osteoblasts, or respiratory epithelial cells. DAS181 did not cause direct or indirect hemolysis. A laboratory abnormality observed in the 28-day toxicology study was mild and transient anemia in male rats at the 3.00 mg/kg dose, which is an expected outcome of enhanced clearance of desialylated red blood cells resulting from systemic exposure with DAS181. Another laboratory observation was a transient dose-dependent elevation in alkaline phosphatase (ALP), which can be attributed to reduced ALP clearance resulting from increased protein desialylation due to DAS181 systemic exposure. These laboratory parameters returned to normal at the end of the recovery period. PMID:21572096

  17. Phase 1 clinical trials of DAS181, an inhaled sialidase, in healthy adults.

    PubMed

    Zenilman, Jonathan M; Fuchs, Edward J; Hendrix, Craig W; Radebaugh, Christine; Jurao, Robert; Nayak, Seema U; Hamilton, Robert G; McLeod Griffiss, J

    2015-11-01

    DAS181, (study drug, Fludase®) was developed for treatment of influenza and parainfluenza infections. Delivered by inhalation, DAS181 cleaves sialic acid receptors from respiratory epithelial cells. Treatment of influenza for three days with DAS181 reduced viral shedding. To increase deposition in the upper airways and decrease systemic absorption, the particle size was increased to 10μm. We conducted two Phase I trials with three cohorts, randomized 2:1, active drug to placebo. The initial cohort got a single 20mg dose of DAS181, or placebo; the second, 20mg DAS181 or placebo for 10days, and the third got 20mg of DAS181 or placebo for 3days. Formulations differed slightly in their excipients. Subjects in the 1- and 3-day cohorts completed dosing without serious adverse events. Two subjects in the 10-day cohort stopped at Day 9 after developing respiratory and systemic symptoms, and a third experienced a decrease in FEV1 (Forced Expiratory Volume in 1s) after the 9th dose and a further decline after the 10th dose. Plasma DAS181, in the 10-day cohort, peaked and began falling before the last dose. Antibodies, predominately IgG with neutralizing activity, were detected in 15/18 subjects by Day 30. The highest IgG concentrations were in the 10-day cohort. The respiratory adverse events occurring after seven days and rapid drug clearance during continued dosing are consistent with the induction of DAS181 antibodies. This could preclude use of this medication for longer than seven days or for repeated courses. (These studies have been registered at ClinicalTrials.gov under registration Nos. NCT 00527865 and NCT 01651494.). PMID:26391974

  18. VIIRS ocean color data visualization and processing with IDL-based NOAA-SeaDAS

    NASA Astrophysics Data System (ADS)

    Wang, Xiaolong; Liu, Xiaoming; Jiang, Lide; Wang, Menghua; Sun, Junqiang

    2014-11-01

    The NOAA Sea-viewing Data Analysis System (NOAA-SeaDAS) is an Interactive Data Language (IDL)-based satellite data visualization, analysis, and processing system based on the version 6.4 of the NASA's Sea-viewing Wide Field-ofview (SeaWiFS) Data Analysis System (SeaDAS) released in 2012. NOAA-SeaDAS inherited all the original functionalities of SeaDAS 6.4 and was upgraded with many new functions and new sensor supports, particularly the support of the Visible Infrared Imaging Radiometer Suite (VIIRS) onboard the Suomi National Polar-Orbiting Partnership (SNPP). The main goal of the NOAA-SeaDAS development is primarily in support of NOAA ocean color team's calibration and validation activities. The current version of NOAA-SeaDAS can visualize, analyze, and process VIIRS Sensor Data Records (SDR or Level-1B data) produced by the NOAA Interface Data Processing System (IDPS), ocean color Environmental Data Records (EDR or Level-2 data) produced by the NOAA Multi-Sensor Level-1 to Level- 2 (MSL12) ocean color data processing system, and Level-3 data binned or mapped from Level-2 data produced by NOAA-MSL12. NOAA-SeaDAS is currently serving an active IDL user group at NOAA and will serve other institutions and universities in the future. The goal is to allow various scientific users to visualize, analyze, and process VIIRS data from Level-1B through Level-2 and Level-3. In addition, NOAA-SeaDAS can also visualize satellite images from the Korean Geostationary Ocean Color Imager (GOCI), as well as many other satellite ocean color sensors, e.g., SeaWiFS, the Moderate Resolution Imaging Spectroradiometer (MODIS), etc. NOAA-SeaDAS is under constant development to create new system functionalities and enhance user experience. With constantly increasing volume in the global ocean color data archive, NOAA-SeaDAS will play an important role in support of global marine environment data analysis and various scientific applications.

  19. BOOK REVIEW: Geheimnisvolles Universum - Europas Astronomen entschleiern das Weltall

    NASA Astrophysics Data System (ADS)

    Duerbeck, H. W.; Lorenzen, D. H.

    2002-12-01

    The 25th birthday of ESO, in 1987, was celebrated by the publication of an illustrated popular book, "Exploring the Southern Sky" (Springer-Verlag 1987), which also saw editions in Danish, English, French, German, and Spanish. Written and illustrated by the ESO staff members Svend Laustsen, Claus Madsen and Richard M. West, its many pictures were mainly taken with the ESO 3.6m and Schmidt telescopes. The structure of the book - perhaps at that time somewhat unusual - started with things far away (Universe and galaxies), zoomed in to the Milky Way, and finally reached the Solar System (with a concluding chapter dealing with the La Silla observatory). Now, with the 4 units of the Very Large Telescope in full operation, and on the occasion of ESO's 40th birthday, another jubilee book has appeared: "Geheimnisvolles Universum: Europas Astronomen entschleiern das Weltall", written by the science journalist Dirk H. Lorenzen, of Hamburg, Germany, and prefaced by Catherine Cesarsky, Director General of ESO. Presumably, this book will also soon become available in more languages spoken in ESO member countries. Thus it may be worthwhile to review the first edition, although some readers may like to wait for more easily accessible editions. Before going into details, let me first mention that I find this a very impressing book, great to look at and refreshing to read. With ESO seen through the eyes of a visitor, things gain a perspective that is quite different from that of the previous book, and at least as attractive. It comes as no surprise that the book starts with a visit of ESO's showcase, the Paranal Observatory, and the writer not only notes down his own impressions, but also cites statements of some of the many people that keep Paranal going - technicians and staff astronomers. This mixture of texts provides a good impression of the operations at a large observatory for the general reader. The two more 'astronomical' parts that follow deal with star and planet

  20. Amerikas Einschätzung der deutschen Atomforschung: Das deutsche Uranprojekt

    NASA Astrophysics Data System (ADS)

    Walker, Mark

    2002-07-01

    Die amerikanischen Wissenschaftler und ihre emigrierten Kollegen, die am Bau der Atombombe beteiligt waren, verfügten über sehr widersprüchliche und großteils falsche Informationen über den Fortschritt des deutschen Uranprogramms. Noch nach Kriegsende lässt sich dies an Aussagen des Leiters der amerikanischen Alsos-Mission, Samuel Goudsmit, festmachen. Tatsächlich war das deutsche Programm hinsichtlich seiner wissenschaftlichen Grundlagen und des Managements nicht so unterlegen, wie vielfach behauptet wurde. Aber die deutschen Behörden waren nicht in der Lage, Geld und Ressourcen in gleichem Maße in das Uranprojekt zu investieren, wie etwa in das Peenemünder Raketenprojekt.

  1. Bottom characterization of Lagoa das Furnas on São Miguel, Azores archipelago

    NASA Astrophysics Data System (ADS)

    Andersson, Tommy; Hermelin, Otto; Skelton, Alasdair; Jakobsson, Martin

    2016-07-01

    Lagoa das Furnas is a crater lake located in an area exposed to geohazards from earthquakes and volcanic activity on the island of São Miguel in the Azores Archipelago. Geophysical mapping of Lagoa das Furnas reveals a previously undiscovered volcanic dome. This dome is comprised largely of subaquatic pyroclastic debris of trachytic composition. Sedimentological, petrological, geochemical and geochronological studies of pyroclastic deposits from the dome link it to the historically documented "Furnas 1630" eruption. The chemistry of glass and crystal fragments sampled from the dome suggests that it is comprised of more evolved magma than that of the main Furnas 1630 dome located 1400 m away. This suggests that the dome was formed during a final phase of the 1630 eruption in the Lagoa das Furnas area.

  2. Anbindung des SISIS-SunRise-Bibliothekssystems an das zentrale Identitätsmanagement

    NASA Astrophysics Data System (ADS)

    Ebner, Ralf; Pretz, Edwin

    Wir berichten über Konzepte und Implementierungen zur Datenprovisionierung aus den Personenverwaltungssystemen der Technischen Universität München (TUM) über das zentrale Metadirectory am Leibniz-Rechenzentrum (LRZ) in das SISIS-SunRise-Bibliothekssystem der Universitätsbibliothek der TUM (TUB). Es werden drei Implementierungsvarianten diskutiert, angefangen von der Generierung und Übertragung einfacher CSV-Dateien über ein OpenLDAP-basiertes Konzept als Backend für die SISIS-Datenbank bis zur endgültigen Implementierung mit dem OCLC IDM Connector.

  3. An exploratory analysis of the factor structure of the Dysfunctional Attitude Scale-Form A (DAS).

    PubMed

    Moore, Michael T; Fresco, David M; Segal, Zindel V; Brown, Timothy A

    2014-10-01

    A number of studies have attempted to identify the factor structure of the Dysfunctional Attitude Scale (DAS). However, no studies have done so using a clinical sample of outpatients likely to generalize to the clinical trials in which the DAS is commonly used. The current investigation utilized exploratory structural equation modeling in an outpatient sample (N = 982) and found support for a one-factor solution (composed of 19 items). This solution was largely confirmed in a second outpatient sample (N = 301). Construct validity was demonstrated in correlations with measures of depression, social interaction anxiety, and symptoms of obsessive-compulsive disorder. PMID:24577308

  4. Das Lob der Sternkunst. Astronomie in der deutschen Aufklärung.

    NASA Astrophysics Data System (ADS)

    Baasner, R.

    Contents: 1. Einleitung. 2. Die Astronomie im Rahmen der Aufklärungs-Physik. 3. Das Lob der Sternkunst. 4. Ein Blick auf die Sternwarten. 5. Allgemeine Darstellungen der Sternkunde. 6. Schleppende Rezeption: Das kopernikanische Weltbild. 7. Himmelsphysik: Die Debatte um die causa gravitatis. 8. Theorie der Himmelskörper. 9. Die Erde als Gegenstand der Astronomie. 10. Die Sonne. 11. Der Mond. 12. Die Planeten. 13. Die Kometen. 14. Die Fixsterne. 15. Die Entstehung der Welt. 16. Beiträge der Astrotheologie. 17. Der Kampf gegen die Astrologen.

  5. The Great War and Remembrance in Jose Leon Machado's "Memoria das Estrelas sem Brilho"

    ERIC Educational Resources Information Center

    Azevedo, Milton M.

    2011-01-01

    This article analyzes Jose Leon Machado's novel, "Memoria das Estrelas sem Brilho," as a multilayered historical novel in which a war story provides a background for comments on aspects of early twentieth-century Portuguese society, such as male bonding, religion, sexual mores, and social stratification. (Contains 11 notes.)

  6. 50 CFR 648.10 - VMS and DAS requirements for vessel owners/operators.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... multispecies Category A or B DAS, or catches regulated species or ocean pout while on a sector trip; or a... an ocean quahog (OQ 6) open access permit; (6) Effective January 1, 2009, a vessel issued a Maine... multispecies limited access permit, a valid surfclam and ocean quahog permit specified at § 648.4(a)(4), or...

  7. MiDAS: the field guide to the microbes of activated sludge.

    PubMed

    McIlroy, Simon Jon; Saunders, Aaron Marc; Albertsen, Mads; Nierychlo, Marta; McIlroy, Bianca; Hansen, Aviaja Anna; Karst, Søren Michael; Nielsen, Jeppe Lund; Nielsen, Per Halkjær

    2015-01-01

    The Microbial Database for Activated Sludge (MiDAS) field guide is a freely available online resource linking the identity of abundant and process critical microorganisms in activated sludge wastewater treatment systems to available data related to their functional importance. Phenotypic properties of some of these genera are described, but most are known only from sequence data. The MiDAS taxonomy is a manual curation of the SILVA taxonomy that proposes a name for all genus-level taxa observed to be abundant by large-scale 16 S rRNA gene amplicon sequencing of full-scale activated sludge communities. The taxonomy can be used to classify unknown sequences, and the online MiDAS field guide links the identity to the available information about their morphology, diversity, physiology and distribution. The use of a common taxonomy across the field will provide a solid foundation for the study of microbial ecology of the activated sludge process and related treatment processes. The online MiDAS field guide is a collaborative workspace intended to facilitate a better understanding of the ecology of activated sludge and related treatment processes--knowledge that will be an invaluable resource for the optimal design and operation of these systems. PMID:26120139

  8. PoroTomo Project - Subatask 6.2: Deploy and Operate DAS and DTS arrays

    DOE Data Explorer

    Dante Fratta

    2016-03-31

    This metadata submission includes the coordinates of the DAS and DTS surface and borehole arrays, the list of file names, and the list of recorded files during testing at the PoroTomo Natural Laboratory at Brady Hot Spring in Nevada. Testing was completed during March 2016.

  9. A Brief History of the J.P. Das Developmental Disabilities Centre

    ERIC Educational Resources Information Center

    Sobsey, Dick

    2008-01-01

    The J.P. Das Developmental Disabilities Centre celebrated its 40th anniversary on September 1, 2007, followed by The University of Alberta's 100th anniversary in 2008. The year 2008 also brought the appointment of a new Director for the Centre. As the immediate past Director of the Centre, the author recounts some of the history of the J.P. Das…

  10. Repeatability of Surface Wave Velocity Estimates from Distributed Acoustic Sensing (DAS) Data

    NASA Astrophysics Data System (ADS)

    Lindsey, N.; Wagner, A. M.; Dou, S.; Martin, E. R.; Ajo Franklin, J. B.; Daley, T. M.; Robertson, M.; Freifeld, B. M.; Bjella, K.; Ulrich, C.

    2015-12-01

    The repeatability of surface wave velocity estimates from local ambient noise hinges on the stability of the crosscorrelation function for the receiver pair in the presence of a variable noise field, assuming near-surface soil properties are invariant over the duration of the surveys. Distributed acoustic sensing (DAS) data recorded on a linear trenched fiber optic cable sensor can accurately sample surface waves in a near continuous fashion (>1 kHz) with high spatial resolution (>1 receiver/m) and long range (10's of km). DAS recordings of ambient noise represent a unique means to explore the practical reliability of field-scale seismic property estimation from seismic interferometry. We test this hypothesis using continuous DAS field recordings from a shallow trench experiment near a busy road with diurnally-variable traffic patterns. Continuous records are processed using a modified ambient noise workflow consisting of receiver pair crosscorrelation, signal stacking, dispersion analysis, and a Monte Carlo search procedure to determine a best-fitting Vs model. The same processing flow is also applied to campaign data acquired with geophones to determine the repeatability benefit of trenched DAS deployment.

  11. MiDAS: the field guide to the microbes of activated sludge

    PubMed Central

    McIlroy, Simon Jon; Saunders, Aaron Marc; Albertsen, Mads; Nierychlo, Marta; McIlroy, Bianca; Hansen, Aviaja Anna; Karst, Søren Michael; Nielsen, Jeppe Lund; Nielsen, Per Halkjær

    2015-01-01

    The Microbial Database for Activated Sludge (MiDAS) field guide is a freely available online resource linking the identity of abundant and process critical microorganisms in activated sludge wastewater treatment systems to available data related to their functional importance. Phenotypic properties of some of these genera are described, but most are known only from sequence data. The MiDAS taxonomy is a manual curation of the SILVA taxonomy that proposes a name for all genus-level taxa observed to be abundant by large-scale 16 S rRNA gene amplicon sequencing of full-scale activated sludge communities. The taxonomy can be used to classify unknown sequences, and the online MiDAS field guide links the identity to the available information about their morphology, diversity, physiology and distribution. The use of a common taxonomy across the field will provide a solid foundation for the study of microbial ecology of the activated sludge process and related treatment processes. The online MiDAS field guide is a collaborative workspace intended to facilitate a better understanding of the ecology of activated sludge and related treatment processes—knowledge that will be an invaluable resource for the optimal design and operation of these systems. Database URL: http://www.midasfieldguide.org PMID:26120139

  12. Incorporating Parallel Computing into the Goddard Earth Observing System Data Assimilation System (GEOS DAS)

    NASA Technical Reports Server (NTRS)

    Larson, Jay W.

    1998-01-01

    Atmospheric data assimilation is a method of combining actual observations with model forecasts to produce a more accurate description of the earth system than the observations or forecast alone can provide. The output of data assimilation, sometimes called the analysis, are regular, gridded datasets of observed and unobserved variables. Analysis plays a key role in numerical weather prediction and is becoming increasingly important for climate research. These applications, and the need for timely validation of scientific enhancements to the data assimilation system pose computational demands that are best met by distributed parallel software. The mission of the NASA Data Assimilation Office (DAO) is to provide datasets for climate research and to support NASA satellite and aircraft missions. The system used to create these datasets is the Goddard Earth Observing System Data Assimilation System (GEOS DAS). The core components of the the GEOS DAS are: the GEOS General Circulation Model (GCM), the Physical-space Statistical Analysis System (PSAS), the Observer, the on-line Quality Control (QC) system, the Coupler (which feeds analysis increments back to the GCM), and an I/O package for processing the large amounts of data the system produces (which will be described in another presentation in this session). The discussion will center on the following issues: the computational complexity for the whole GEOS DAS, assessment of the performance of the individual elements of GEOS DAS, and parallelization strategy for some of the components of the system.

  13. Flashbacks: Reminiscences from 40 Years with the J.P. Das Developmental Disabilities Centre

    ERIC Educational Resources Information Center

    Das, J. P.

    2008-01-01

    In this article, the author reminisces about his 40 years with the J.P. Das Developmental Disabilities Centre. He begins by recalling his early years with the Centre. He follows it up with his middle years, as well as his later years with the Centre. The author ends his flashback by "bragging" about some of the extraordinary scholars who have…

  14. A 90 day chronic toxicity study of Nigerian herbal preparation DAS-77 in rats

    PubMed Central

    2012-01-01

    Background The herbal preparation DAS-77, used for the treatment of various ailments in Nigeria, contains the milled bark of Mangifera indica L. and root of Carica papaya L. Toxicological assessment of the preparation was carried out in this study. Methods In the acute toxicity study, DAS-77 was administered to mice p.o. up to 20 g/kg in divided doses and i.p. at 250–3000 mg/kg. Mortality within 24 h was recorded. In the chronic toxicity study, rats were treated p.o. for 90 days at doses of 80, 400 (therapeutic dose, TD) and 2000 mg/kg. By 90 days, animals were sacrificed and blood samples collected for hematological and biochemical analysis. Organs were harvested for weight determination, antioxidants and histopathological assessments. Results DAS-77 did not produce any lethality administered p.o. up to 20 g/kg in divided doses but the i.p. LD50 was 1122.0 mg/kg. At TD, DAS-77 produced significant (p < 0.05) reductions in body weight, food intake and K+, and increases in ovary weight, neutrophils and HDL, which were reversible. Histopathological presentations were generally normal. Effects at the other doses were comparable to those at TD except for reversible increases in antioxidants in the liver, kidney and testes, and sperm abnormality, and reductions in liver enzymes, sperm motility and count. Conclusions Findings in this study revealed that DAS-77 is relatively safe with the potential for enhancing in vivo antioxidant activity. However, possibly reversible side-effects include electrolyte imbalance and sterility in males. PMID:22892317

  15. Annotation and visualization of endogenous retroviral sequences using the Distributed Annotation System (DAS) and eBioX

    PubMed Central

    Martínez Barrio, Álvaro; Lagercrantz, Erik; Sperber, Göran O; Blomberg, Jonas; Bongcam-Rudloff, Erik

    2009-01-01

    Background The Distributed Annotation System (DAS) is a widely used network protocol for sharing biological information. The distributed aspects of the protocol enable the use of various reference and annotation servers for connecting biological sequence data to pertinent annotations in order to depict an integrated view of the data for the final user. Results An annotation server has been devised to provide information about the endogenous retroviruses detected and annotated by a specialized in silico tool called RetroTector. We describe the procedure to implement the DAS 1.5 protocol commands necessary for constructing the DAS annotation server. We use our server to exemplify those steps. Data distribution is kept separated from visualization which is carried out by eBioX, an easy to use open source program incorporating multiple bioinformatics utilities. Some well characterized endogenous retroviruses are shown in two different DAS clients. A rapid analysis of areas free from retroviral insertions could be facilitated by our annotations. Conclusion The DAS protocol has shown to be advantageous in the distribution of endogenous retrovirus data. The distributed nature of the protocol is also found to aid in combining annotation and visualization along a genome in order to enhance the understanding of ERV contribution to its evolution. Reference and annotation servers are conjointly used by eBioX to provide visualization of ERV annotations as well as other data sources. Our DAS data source can be found in the central public DAS service repository, , or at . PMID:19534743

  16. A Letter to the Parent(s) of a Child with Developmental Apraxia of Speech. Part II: The Nature and Causes of DAS.

    ERIC Educational Resources Information Center

    Hall, Penelope K.

    2000-01-01

    One of a series of letters to parents of children with developmental apraxia of speech (DAS), this letter discusses issues and current thinking about the nature and causes of the disorder. These include the idea that DAS is a disorder of overall language development or that DAS is a problem of the "motor-programming" system for speech. An…

  17. Lernen durch Kulturkontakt (Learning through Acculturation).

    ERIC Educational Resources Information Center

    Hesse, Hermann-Gunter

    "Experiences in Acculturation: What Is Being Learned?" is the first of two papers in this volume. It reports on a study of social representations and their development during cultural contacts conducted with beginning teachers who were studied over time and through comparison with cross-culturally competent experts with the aim of putting…

  18. Proposal of adaptive wireless cell configuration for RoF-DAS over WDM-PON system

    NASA Astrophysics Data System (ADS)

    Iwakuni, Tatsuhiko; Miyamoto, Kenji; Higashino, Takeshi; Tsukamoto, Katsutoshi; Komaki, Shozo; Tashiro, Takayoshi; Fukada, Youichi; Kani, Jun-ichi; Yoshimoto, Naoto; Iwatsuki, Katsumi

    2013-01-01

    Radio on fiber (RoF) - distributed antenna system (DAS) over wavelength division multiplexing - passive optical network (WDM-PON) with multiple - input multiple - output (MIMO) has been proposed as a next generation radio access network (RAN). This system employs optical time division multiplexing (OTDM) over one WDM channel to multiplex and transmit various types of wireless interfaces such as 3.9G, Wireless LAN and WiMAX. A combination of star and bus topologies has employed to cover a wider service area. The optical transmission loss is caused notably at remote base stations (RBSs) quipped on a WDM bus link. The loss is relatively small, but at the RBS far from the center station (CS), the RBS suffers the large accumulated loss, so the reduction of cell size provides the increasing of the number of RBSs, causes the degradation of the SNR of RoF link. This paper addresses this trade-off problem, and considers the application to the actual service area by the channel capacity investigation of RoF-DAS over WDM-PON with computer simulation. Then, this paper focuses on the flexibility of RoF-DAS over WDM-PON, considers the adaptive wireless cell configuration according to population fluctuations of day and night, or densely populated areas and sparsely populated areas, respectively.

  19. pH modulates arsenic toxicity in Bacillus licheniformis DAS-2.

    PubMed

    Tripti, K; Shardendu

    2016-08-01

    The toxic characteristics of arsenic species, As(V) and As(III) result in ecological risks. Arsenic tolerant bacterium was isolated and identified as the Bacillus licheniformis DAS-2 through 16SrDNA sequencing. B. licheniformis DAS-2 was efficient to tolerate and remove both the As(V)[MIC 8mM] and As(III)[MIC 6mM] from the growth medium. The potential for the removal/uptake of arsenic from the 3, 5 and 7mM As(V) enriched growth media was 100%, 60% and 35% respectively and from the 1, 3 and 5mM As(III) enrichment it was 100%, 99% and 58% respectively at neutral pH. 80% of uptake As(V) was reduced to As(III) in 3mM As(V) enrichment which was gradually decreased to only 17% at 7mM As(V) enrichment at neutral pH. The arsenic toxicity in B. licheniformis DAS-2 was found modulated by pH and was examined through alteration in growth, uptake/removal, reduction and measurement of chemical toxicity. PMID:27135959

  20. DAS Boot!

    ERIC Educational Resources Information Center

    Chretien, Wendy

    2007-01-01

    The residential services group is lobbying to dump its aging hard-wired phone system because students don't use it. The town and campus public safety officials are demanding that their portable two-way radios operate well not only outdoors, but within campus buildings. Students are now expecting text messaging and WiFi service to work everywhere…

  1. I/O Parallelization for the Goddard Earth Observing System Data Assimilation System (GEOS DAS)

    NASA Technical Reports Server (NTRS)

    Lucchesi, R.; Sawyer, W.; Takacs, L. L.; Lyster, P.; Zero, J.

    1999-01-01

    The National Aeronautics and Space Administration (NASA) Data Assimilation Office (DAO) at the Goddard Space Flight Center (GSFC) has developed the GEOS DAS, a data assimilation system that provides production support for NASA missions and will support NASA's Earth Observing System (EOS) in the coming years. The DAO's support of the EOS project along with the requirement of producing long-term reanalysis datasets with an unvarying system levy a large I/O burden on the future system. The DAO has been involved in prototyping parallel implementations of the GEOS DAS for a number of years and is now converting the production version from shared-memory parallelism to distributed-memory parallelism using the portable Message-Passing Interface (MPI). If the MPI-based GEOS DAS is to meet these production requirements, we must make I/O from the parallel system efficient. We have designed a scheme that allows efficient I/O processing while retaining portability, reducing the need for post-processing, and producing data formats that are required by our users, both internal and external. The first phase of the GEOS DAS Parallel I/O System (GPIOS) will expand upon the common method of gathering global data to a Single PE for output. Instead of using a PE also tasked with primary computation, a number of PEs will be dedicated to I/O and its related tasks. This allows the data transformations and formatting required prior to output to take place asynchronously with respect to the GEOS DAS assimilation cycle, improving performance and generating output data sets in a format convenient for our users. I/O PEs can be added as needed to handle larger data volumes or to meet user file specifications. We will show I/O performance results from a prototype MPI GCM integrated with GPIOS. Phase two of GPIOS development will examine ways of integrating new software technologies to further improve performance and build scalability into the system. The maturing of MPI-IO implementations and

  2. DAS28 score vs. ultrasound examination for assessment of rheumatoid arthritis disease activity: comparison and discussion of pros and cons

    PubMed Central

    Dura, Marta; Blumfield, Einat; Węgierska, Małgorzata; Żuchowski, Pawel; Wilińska-Jankowska, Arnika; Jeka, Sławomir

    2015-01-01

    Rheumatoid arthritis (RA) is a chronic systemic connective tissue disease which is characterized by symetrical multiple joints involvement and extra-articular symptoms. Current EULAR diagnostic criteria for RA include disease activity parameters, such as erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), which are used to calculate disease activity scores, including DAS and DAS28. Recently attempts have been made to assess disease activity using imaging diagnostic modalities, such as magnetic resonance imaging (MRI) and ultrasonography (US). Due to significant progress in therapy effectiveness and early RA diagnosis possibility, imaging modalities become increasingly meaningful and many clinical trials confirm their usefulness. However, there are no consistent criteria for objective assessment of therapy effectiveness based on US. Moreover, it is not US availability that limits its common use, but rather significant variability between operators. This is why US remains only an additional tool to assess therapy efficacy with regard to DAS/DAS28 index.

  3. The WHO-DAS II: psychometric properties in the measurement of functional health status in adults with acquired hearing loss.

    PubMed

    Chisolm, Theresa H; Abrams, Harvey B; McArdle, Rachel; Wilson, Richard H; Doyle, Patrick J

    2005-01-01

    The World Health Organization's (WHO) Disability Assessment Scale II (WHO-DAS II) is a generic health-status instrument firmly grounded in the WHO's International Classification of Functioning, Disability and Health (WHO-ICF). As such, it assesses functioning for six domains: communication, mobility, self-care, interpersonal, life activities, and participation. Domain scores aggregate to a total score. Because the WHO-DAS II contains questions relevant to hearing and communication, it has good face validity for use as an outcome measure for audiologic intervention. The purpose of the present study was to determine the psychometric properties of the WHO-DAS II on a sample of individuals with adult-onset hearing loss, including convergent validity, internal consistency, and test-retest stability. Convergent validity was established by examining correlations between the WHO-DAS II (domain and total scores) and the Abbreviated Profile of Hearing Aid Benefit (APHAB) and the Hearing Aid Handicap for the Elderly (HHIE), two disease-specific measures, as well as with the Short Form-36 for veterans (SF-36V), a second generic measure. Data on all four measures were collected from 380 older individuals with adult-onset hearing loss who were not hearing aid users. The results of the convergent validity analysis revealed that the WHODAS II communication domain score was moderately and significantly correlated with scores on the APHAB and the HHIE. WHO-DAS II interpersonal and participation domain scores and the total scores were also moderately and significantly correlated with HHIE scores. These findings support the validity of using the WHO-DAS II for assessing activity limitations and participation restrictions of adult-onset hearing loss. Several WHO-DAS II domain scores and the total score were also significantly and moderately-markedly correlated with scores from the SF-36V. These findings support the validity of the WHO-DAS II as a generic health-status instrument

  4. Validation of Land-Surface Mosaic Heterogeneity in the GEOS DAS

    NASA Technical Reports Server (NTRS)

    Bosilovich, Michael G.; Molod, Andrea; Houser, Paul R.; Schubert, Siegfried

    1999-01-01

    The Mosaic Land-surface Model (LSM) has been included into the current GEOS Data Assimilation System (DAS). The LSM uses a more advanced representation of physical processes than previous versions of the GEOS DAS, including the representation of sub-grid heterogeneity of the land-surface through the Mosaic approach. As a first approximation, Mosaic assumes that all similar surface types within a grid-cell can be lumped together as a single'tile'. Within one GCM grid-cell, there might be 1 - 5 different tiles or surface types. All tiles are subjected to the grid-scale forcing (radiation, air temperature and specific humidity, and precipitation), and the sub-grid variability is a function of the tile characteristics. In this paper, we validate the LSM sub-grid scale variability (tiles) using a variety of surface observing stations from the Southern Great Plains (SGP) site of the Atmospheric Radiation Measurement (ARM) Program. One of the primary goals of SGP ARM is to study the variability of atmospheric radiation within a G,CM grid-cell. Enough surface data has been collected by ARM to extend this goal to sub-grid variability of the land-surface energy and water budgets. The time period of this study is the Summer of 1998 (June I - September 1). The ARM site data consists of surface meteorology, energy flux (eddy correlation and bowen ratio), soil water observations spread over an area similar to the size of a G-CM grid-cell. Various ARM stations are described as wheat and alfalfa crops, pasture and range land. The LSM tiles considered at the grid-space (2 x 2.5) nearest the ARM site include, grassland, deciduous forests, bare soil and dwarf trees. Surface energy and water balances for each tile type are compared with observations. Furthermore, we will discuss the land-surface sub-grid variability of both the ARM observations and the DAS.

  5. The S2 VLBI Systems: DAS, RT/PT and Correlator

    NASA Technical Reports Server (NTRS)

    Petrachenko, William T.; Bujold, Marc; Cannon, Wayne H.; Carlson, Brent R.; Dewdney, Peter E.; Feil, Georg H.; Newby, Paul; Novikov, Alexander; Popelar, Josef; Wietfeldt, Richard D.

    2000-01-01

    The S2 VLBI system synthesizes wide IF bandwidths by rapidly switching the local oscillator (LO) frequency in a small (1-4) number of baseband converters (BBC's). Data are recorded on video cassettes using an array of 8 VHS transports. Characteristics of the S2 Data Acquisition System (DAS), the S2 Record and Playback Terminals (RT and PT) and the S2 Correlator are summarized. The bandwidth synthesis (BWS) frequency switching sequence used in a series of system validation experiments is presented.

  6. Das Neutron, der Kosmos und die Kräfte: Neutronen in der Teilchenphysik

    NASA Astrophysics Data System (ADS)

    Soldner, Torsten

    2003-05-01

    Das Neutron besitzt eine einzigartige Kombination von Eigenschaften. Sie ermöglicht die Untersuchung aller vier elementaren Kräfte. Dabei wurden beeindruckende Resultate erzielt, wie die Präzisionsmessungen der elektrischen Ladung des Neutrons oder der Feinstrukturkonstante zeigen. Die genaue Bestimmung der schwachen Wechselwirkungsstärke der Nukleonen liefert der Astrophysik wichtige Daten. Die Messung eines von Null verschiedenen elektrischen Dipolmoments des Neutrons könnte einen entscheidenden Hinweis über die Physik jenseits des Standardmodells der Teilchenphysik geben. Doch auch zur Aufklärung von Unsicherheiten innerhalb des Standardmodells selbst tragen Neutronen bei.

  7. Datta-and-Das spin transistor controlled by a high-frequency electromagnetic field

    NASA Astrophysics Data System (ADS)

    Sheremet, A. S.; Kibis, O. V.; Kavokin, A. V.; Shelykh, I. A.

    2016-04-01

    We developed the theory of spin dependent transport through a spin-modulator device (so-called Datta-and-Das spin transistor) in the presence of a high-frequency electromagnetic field (dressing field). Solving the Schrödinger problem for dressed electrons, we demonstrated that the field drastically modifies the spin transport. In particular, the dressing field leads to renormalization of spin-orbit coupling constants that varies conductivity of the spin transistor. The present effect paves the way for controlling the spin-polarized electron transport with light in prospective spin-optronic devices.

  8. Genome-Wide Analysis of In Vivo Binding of the Master Regulator DasR in Streptomyces coelicolor Identifies Novel Non-Canonical Targets

    PubMed Central

    Świątek-Połatyńska, Magdalena A.; Bucca, Giselda; Laing, Emma; Gubbens, Jacob; Titgemeyer, Fritz; Smith, Colin P.; Rigali, Sébastien; van Wezel, Gilles P.

    2015-01-01

    Streptomycetes produce a wealth of natural products, including over half of all known antibiotics. It was previously demonstrated that N-acetylglucosamine and secondary metabolism are closely entwined in streptomycetes. Here we show that DNA recognition by the N-acetylglucosamine-responsive regulator DasR is growth-phase dependent, and that DasR can bind to sites in the S. coelicolor genome that have no obvious resemblance to previously identified DasR-responsive elements. Thus, the regulon of DasR extends well beyond what was previously predicted and includes a large number of genes with functions far removed from N-acetylglucosamine metabolism, such as genes for small RNAs and DNA transposases. Conversely, the DasR regulon during vegetative growth largely correlates to the presence of canonical DasR-responsive elements. The changes in DasR binding in vivo following N-acetylglucosamine induction were studied in detail and a possible molecular mechanism by which the influence of DasR is extended is discussed. Discussion of DasR binding was further informed by a parallel transcriptome analysis of the respective cultures. Evidence is provided that DasR binds directly to the promoters of all genes encoding pathway-specific regulators of antibiotic production in S. coelicolor, thereby providing an exquisitely simple link between nutritional control and secondary metabolism. PMID:25875084

  9. The development of Music in Dementia Assessment Scales (MiDAS)

    PubMed Central

    McDermott, Orii; Orrell, Martin; Ridder, Hanne Mette

    2015-01-01

    There is a need to develop an outcome measure specific to music therapy in dementia that reflects a holistic picture of the therapy process and outcome. This study aimed to develop a clinically relevant and scientifically robust music therapy outcome measure incorporating the values and views of people with dementia. Focus groups and interviews were conducted to obtain qualitative data on what music meant to people with dementia and the observed effects of music. Expert and peer consultations were conducted at each stage of the measure development to maximise its content validity. The new measure was field-tested by clinicians in a care home. Feedback from the clinicians and music therapy experts were incorporated during the review and refinement process of the measure. A review of the existing literature, the experiential results and the consensus process enabled the development of the new outcome measure “Music in Dementia Assessment Scales (MiDAS)”. Analysis of the qualitative data identified five key areas of the impact of music on people with dementia and they were transformed as the five Visual Analogue Scale (VAS) items: levels of Interest, Response, Initiation, Involvement and Enjoyment. MiDAS comprises the five VAS items and a supplementary checklist of notable positive and negative reactions from the individual. This study demonstrates that it is possible to design and develop an easy to apply and rigorous quantitative outcome measure which has a high level of clinical relevance for people with dementia, care home staff and music therapists. PMID:26246670

  10. Hermann Cohen's Das Princip der Infinitesimal-Methode: The history of an unsuccessful book.

    PubMed

    Giovanelli, Marco

    2016-08-01

    This paper offers an introduction to Hermann Cohen's Das Princip der Infinitesimal-Methode (1883), and recounts the history of its controversial reception by Cohen's early sympathizers, who would become the so-called 'Marburg school' of Neo-Kantianism, as well as the reactions it provoked outside this group. By dissecting the ambiguous attitudes of the best-known representatives of the school (Paul Natorp and Ernst Cassirer), as well as those of several minor figures (August Stadler, Kurd Lasswitz, Dimitry Gawronsky, etc.), this paper shows that Das Princip der Infinitesimal-Methode is a unicum in the history of philosophy: it represents a strange case of an unsuccessful book's enduring influence. The "puzzle of Cohen's Infinitesimalmethode," as we will call it, can be solved by looking beyond the scholarly results of the book, and instead focusing on the style of philosophy it exemplified. Moreover, the paper shows that Cohen never supported, but instead explicitly opposed, the doctrine of the centrality of the 'concept of function', with which Marburg Neo-Kantianism is usually associated. PMID:27474182

  11. Ocean Color Measurements from Landsat-8 OLI using SeaDAS

    NASA Technical Reports Server (NTRS)

    Franz, Bryan Alden; Bailey, Sean W.; Kuring, Norman; Werdell, P. Jeremy

    2014-01-01

    The Operational Land Imager (OLI) is a multi-spectral radiometer hosted on the recently launched Landsat-8 satellite. OLI includes a suite of relatively narrow spectral bands at 30-meter spatial resolution in the visible to shortwave infrared that make it a potential tool for ocean color radiometry: measurement of the reflected spectral radiance upwelling from beneath the ocean surface that carries information on the biogeochemical constituents of the upper ocean euphotic zone. To evaluate the potential of OLI to measure ocean color, processing support was implemented in SeaDAS, which is an open-source software package distributed by NASA for processing, analysis, and display of ocean remote sensing measurements from a variety of satellite-based multi-spectral radiometers. Here we describe the implementation of OLI processing capabilities within SeaDAS, including support for various methods of atmospheric correction to remove the effects of atmospheric scattering and absorption and retrieve the spectral remote-sensing reflectance (Rrs; sr exp 1). The quality of the retrieved Rrs imagery will be assessed, as will the derived water column constituents such as the concentration of the phytoplankton pigment chlorophyll a.

  12. Trends and variability of climate and river flow in the region of Costa das Baleias, Brazil.

    PubMed

    Genz, F; Tanajura, C A S

    2013-01-01

    There is an ongoing effort by the scientific community to regionalize climate studies to support local development plans. The area of interest is the Costa das Baleias on the east coast of northeast Brazil. It is located in a transition region of precipitation trends, and so assessing the local signal and magnitude is necessary. A series of annual anomalies of surface air temperature, precipitation and river discharge were analyzed from 1946 to 2010. The modified Mann-Kendall test was applied to detect trends. Temperature anomalies showed a consistent positive trend since 1950. Precipitation anomalies tended to decrease, though not significantly. River discharge rates showed a consistent positive trend. However, from the 1980s onwards, both the precipitation and the river discharge anomalies had the same decreasing tendency. The precipitation and discharge behavior are likely due to the combined effect of human interventions in the river basins including local, synoptic and global climate effects. The inter-annual variability was characterized by spectral analysis. Cycles were identified for the precipitation and the river discharge with periods of 2-3 years, 3-4 years, 7-8 years and 11-12 years. The decadal frequency is consistent with the South Atlantic and El Niño indices. This work strongly indicates that climate is changing in Costa das Baleias and further work is needed to investigate the mechanisms that link local to large-scale variability. PMID:23128620

  13. A causa das estações do ano: modelos mentais

    NASA Astrophysics Data System (ADS)

    de Campos, J. A. S.; de Araujo, J. F. S.

    2003-08-01

    A década de 70 do século passado foi marcada pelo estudo das concepções alternativas que os alunos trazem para a sala de aula. A identificação destas concepções foi o ponto de partida para promover a mudança conceitual, onde as pré-concepções seriam trocadas pelas concepções científicas. Na década seguinte, surgiram muitas propostas de estratégias educacionais para facilitar esta troca, na sua maioria baseadas na idéia do conflito cognitivo, proposta por Piaget. Entretanto, os resultados pouco animadores conduziram à percepção de que a mudança conceitual é um processo mais complexo. Pelas idéias da Ciência Cognitiva, a mudança conceitual é uma mudança progressiva dos modelos mentais que o aluno tem sobre o mundo físico, através de enriquecimento e revisão. A causa das Estações do Ano é um tópico sobre o qual a maioria dos estudantes apresenta concepções alternativas. Os autores fizeram um levantamento sobre as pré-concepções encontradas em trabalhos sobre o tema (16 referências), procurando encontrar elementos comuns que indicassem a presença de modelos mentais específicos. As pré-concepções encontradas na literatura foram obtidas usando-se diversas metodologias (desde entrevistas clínicas até questionários de múltipla escolha) e envolvendo alunos e professores de diferentes regiões geográficas. A partir de uma análise aprofundada de cada trabalho, e utilizando-se a técnica das Redes Sistêmicas, chegou-se a conclusão que as diversas pré-concepções identificadas (em torno de 50), poderiam ser representadas por 6 modelos mentais, onde a explicação da causa das estações do ano tem um mecanismo causal responsável. Os mecanismos causais identificados foram: a dependência da distância, a dependência da orientação, a dependência conjunta da distância e orientação, a dependência da obstrução, a dependência da velocidade e a dependência da inclinação dos raios solares. Foram ainda identificadas

  14. Measuring Primary Teachers' Attitudes Toward Teaching Science: Development of the Dimensions of Attitude Toward Science (DAS) Instrument

    NASA Astrophysics Data System (ADS)

    van Aalderen-Smeets, Sandra; Walma van der Molen, Juliette

    2013-03-01

    In this article, we present a valid and reliable instrument which measures the attitude of in-service and pre-service primary teachers toward teaching science, called the Dimensions of Attitude Toward Science (DAS) Instrument. Attention to the attitudes of primary teachers toward teaching science is of fundamental importance to the professionalization of these teachers in the field of primary science education. With the development of this instrument, we sought to fulfill the need for a statistically and theoretically valid and reliable instrument to measure pre-service and in-service teachers' attitudes. The DAS Instrument is based on a comprehensive theoretical framework for attitude toward (teaching) science. After pilot testing, the DAS was revised and subsequently validated using a large group of respondents (pre-service and in-service primary teachers) (N = 556). The theoretical underpinning of the DAS combined with the statistical data indicate that the DAS possesses good construct validity and that it proves to be a promising instrument that can be utilized for research purposes, and also as a teacher training and coaching tool. This instrument can therefore make a valuable contribution to progress within the field of science education.

  15. Establishment of feeder-free culture system for human induced pluripotent stem cell on DAS nanocrystalline graphene

    NASA Astrophysics Data System (ADS)

    Lee, Hyunah; Nam, Donggyu; Choi, Jae-Kyung; Araúzo-Bravo, Marcos J.; Kwon, Soon-Yong; Zaehres, Holm; Lee, Taehee; Park, Chan Young; Kang, Hyun-Wook; Schöler, Hans R.; Kim, Jeong Beom

    2016-02-01

    The maintenance of undifferentiated human pluripotent stem cells (hPSC) under xeno-free condition requires the use of human feeder cells or extracellular matrix (ECM) coating. However, human-derived sources may cause human pathogen contamination by viral or non-viral agents to the patients. Here we demonstrate feeder-free and xeno-free culture system for hPSC expansion using diffusion assisted synthesis-grown nanocrystalline graphene (DAS-NG), a synthetic non-biological nanomaterial which completely rule out the concern of human pathogen contamination. DAS-NG exhibited advanced biocompatibilities including surface nanoroughness, oxygen containing functional groups and hydrophilicity. hPSC cultured on DAS-NG could maintain pluripotency in vitro and in vivo, and especially cell adhesion-related gene expression profile was comparable to those of cultured on feeders, while hPSC cultured without DAS-NG differentiated spontaneously with high expression of somatic cell-enriched adhesion genes. This feeder-free and xeno-free culture method using DAS-NG will facilitate the generation of clinical-grade hPSC.

  16. Establishment of feeder-free culture system for human induced pluripotent stem cell on DAS nanocrystalline graphene.

    PubMed

    Lee, Hyunah; Nam, Donggyu; Choi, Jae-Kyung; Araúzo-Bravo, Marcos J; Kwon, Soon-Yong; Zaehres, Holm; Lee, Taehee; Park, Chan Young; Kang, Hyun-Wook; Schöler, Hans R; Kim, Jeong Beom

    2016-01-01

    The maintenance of undifferentiated human pluripotent stem cells (hPSC) under xeno-free condition requires the use of human feeder cells or extracellular matrix (ECM) coating. However, human-derived sources may cause human pathogen contamination by viral or non-viral agents to the patients. Here we demonstrate feeder-free and xeno-free culture system for hPSC expansion using diffusion assisted synthesis-grown nanocrystalline graphene (DAS-NG), a synthetic non-biological nanomaterial which completely rule out the concern of human pathogen contamination. DAS-NG exhibited advanced biocompatibilities including surface nanoroughness, oxygen containing functional groups and hydrophilicity. hPSC cultured on DAS-NG could maintain pluripotency in vitro and in vivo, and especially cell adhesion-related gene expression profile was comparable to those of cultured on feeders, while hPSC cultured without DAS-NG differentiated spontaneously with high expression of somatic cell-enriched adhesion genes. This feeder-free and xeno-free culture method using DAS-NG will facilitate the generation of clinical-grade hPSC. PMID:26846167

  17. Establishment of feeder-free culture system for human induced pluripotent stem cell on DAS nanocrystalline graphene

    PubMed Central

    Lee, Hyunah; Nam, Donggyu; Choi, Jae-Kyung; Araúzo-Bravo, Marcos J.; Kwon, Soon-Yong; Zaehres, Holm; Lee, Taehee; Park, Chan Young; Kang, Hyun-Wook; Schöler, Hans R.; Kim, Jeong Beom

    2016-01-01

    The maintenance of undifferentiated human pluripotent stem cells (hPSC) under xeno-free condition requires the use of human feeder cells or extracellular matrix (ECM) coating. However, human-derived sources may cause human pathogen contamination by viral or non-viral agents to the patients. Here we demonstrate feeder-free and xeno-free culture system for hPSC expansion using diffusion assisted synthesis-grown nanocrystalline graphene (DAS-NG), a synthetic non-biological nanomaterial which completely rule out the concern of human pathogen contamination. DAS-NG exhibited advanced biocompatibilities including surface nanoroughness, oxygen containing functional groups and hydrophilicity. hPSC cultured on DAS-NG could maintain pluripotency in vitro and in vivo, and especially cell adhesion-related gene expression profile was comparable to those of cultured on feeders, while hPSC cultured without DAS-NG differentiated spontaneously with high expression of somatic cell-enriched adhesion genes. This feeder-free and xeno-free culture method using DAS-NG will facilitate the generation of clinical-grade hPSC. PMID:26846167

  18. DasPy – Open Source Multivariate Land Data Assimilation Framework with High Performance Computing

    NASA Astrophysics Data System (ADS)

    Han, Xujun; Li, Xin; Montzka, Carsten; Kollet, Stefan; Vereecken, Harry; Hendricks Franssen, Harrie-Jan

    2015-04-01

    Data assimilation has become a popular method to integrate observations from multiple sources with land surface models to improve predictions of the water and energy cycles of the soil-vegetation-atmosphere continuum. In recent years, several land data assimilation systems have been developed in different research agencies. Because of the software availability or adaptability, these systems are not easy to apply for the purpose of multivariate land data assimilation research. Multivariate data assimilation refers to the simultaneous assimilation of observation data for multiple model state variables into a simulation model. Our main motivation was to develop an open source multivariate land data assimilation framework (DasPy) which is implemented using the Python script language mixed with C++ and Fortran language. This system has been evaluated in several soil moisture, L-band brightness temperature and land surface temperature assimilation studies. The implementation allows also parameter estimation (soil properties and/or leaf area index) on the basis of the joint state and parameter estimation approach. LETKF (Local Ensemble Transform Kalman Filter) is implemented as the main data assimilation algorithm, and uncertainties in the data assimilation can be represented by perturbed atmospheric forcings, perturbed soil and vegetation properties and model initial conditions. The CLM4.5 (Community Land Model) was integrated as the model operator. The CMEM (Community Microwave Emission Modelling Platform), COSMIC (COsmic-ray Soil Moisture Interaction Code) and the two source formulation were integrated as observation operators for assimilation of L-band passive microwave, cosmic-ray soil moisture probe and land surface temperature measurements, respectively. DasPy is parallelized using the hybrid MPI (Message Passing Interface) and OpenMP (Open Multi-Processing) techniques. All the input and output data flow is organized efficiently using the commonly used NetCDF file

  19. Taxonomic notes and distribution extension of Durga Das's leaf-nosed bat Hipposiderosdurgadasi Khajuria, 1970 (Chiroptera: Hipposideridae) from south India.

    PubMed

    Kaur, Harpreet; Chelmala, Srinivasulu; Srinivasulu, Bhargavi; Shah, Tariq Ahmed; Devender, Gundena; Srinivasulu, Aditya

    2014-01-01

    Durga Das's leaf-nosed bat Hipposiderosdurgadasi Khajuria, 1970 is endemic to India, and was known only from Katanga, Katangi, and Richhai villages, in Jabalpur district, Madhya Pradesh. During surveys conducted in Kolar district, Karnataka, India, we successfully mist-netted a few individuals belonging to the bicolor species group which, upon detailed external, craniodental and bacular studies were identified as Durga Das's leaf-nosed bat. This paper reports the presence of this species in southern India, extending its distribution range by almost 1300 km. We also provide a detailed morphological description for this species. PMID:25535483

  20. Event DAS-444Ø6-6 soybean grown in Brazil is compositionally equivalent to non-transgenic soybean.

    PubMed

    Fast, Brandon J; Galan, Maria P; Schafer, Ariane C

    2016-04-01

    Soybean event DAS-444Ø6-6 is tolerant to the herbicides 2,4-D, glyphosate, and glufosinate. An investigation of potential unintended adverse compositional changes in a genetically modified crop is required to meet government regulatory requirements in various geographies. A study to meet these requirements in Brazil was completed demonstrating compositional equivalency between DAS-444Ø6-6 and non-transgenic soybean. This study supplements the extensive literature supporting transgenesis as less disruptive of crop composition compared with traditional breeding methods. PMID:27248569

  1. Planning Ability across Ranges of Intellectual Ability: An Examination of the Luria-Das Information-Processing Model.

    ERIC Educational Resources Information Center

    McCallum, R. Steve; And Others

    1988-01-01

    Based on Luria-Das information processing theory, hypothesized that 26 educable mentally retarded children would score significantly less well on relatively pure measures of planning ability than would 13 younger average ability students after students were matched on cognitive processing ability. Hypothesis was not supported by study. (Author/NB)

  2. Latent Factor Structure of the Das-Naglieri Cognitive Assessment System: A Confirmatory Factor Analysis in a Chinese Setting

    ERIC Educational Resources Information Center

    Deng, Ci-ping; Liu, Ming; Wei, Wei; Chan, Raymond C. K.; Das, J. P.

    2011-01-01

    This study aims to measure the psychometric properties of the Das-Naglieri Cognitive Assessment System (D-N CAS) and to determine its clinical utility in a Chinese context. Confirmatory factor analysis (CFA) was conducted to examine the construct validity of the Chinese version of the D-N CAS among a group of 567, normally developed children.…

  3. Test Review: Naglieri, J. A., Das, J. P., & Goldstein, S. (2014). Cognitive Assessment System-Second Edition (2nd Ed.)

    ERIC Educational Resources Information Center

    McGill, Ryan J.

    2015-01-01

    The Cognitive Assessment System-Second Edition (CAS2) is an individually administered measure of cognitive ability designed for children and adolescents ages 5 through 18 years. The measure, authored by Jack A. Naglieri, J. P. Das, and Sam Goldstein, was published by Pro-Ed in 2014 and is the first revision of the Cognitive Assessment System (CAS;…

  4. Concurrent Validity of the WISC-IV and DAS-II in Children with Autism Spectrum Disorder

    ERIC Educational Resources Information Center

    Kuriakose, Sarah

    2014-01-01

    Cognitive assessments are used for a variety of research and clinical purposes in children with autism spectrum disorder (ASD). This study establishes concurrent validity of the Wechsler Intelligence Scales for Children-fourth edition (WISC-IV) and Differential Ability Scales-second edition (DAS-II) in a sample of children with ASD with a broad…

  5. DAS181 Treatment of Severe Parainfluenza Virus 3 Pneumonia in Allogeneic Hematopoietic Stem Cell Transplant Recipients Requiring Mechanical Ventilation

    PubMed Central

    Dhakal, B.; D'Souza, A.; Pasquini, M.; Saber, W.; Fenske, T. S.; Moss, R. B.; Drobyski, W. R.; Hari, P.; Abidi, M. Z.

    2016-01-01

    Parainfluenza virus (PIV) may cause life-threatening pneumonia in allogeneic hematopoietic stem cell transplant (HSCT) recipients. Currently, there are no proven effective therapies. We report the use of inhaled DAS181, a novel sialidase fusion protein, for treatment of PIV type 3 pneumonia in two allogeneic hematopoietic SCT recipients with respiratory failure. PMID:26941799

  6. Measuring Primary Teachers' Attitudes toward Teaching Science: Development of the Dimensions of Attitude toward Science (DAS) Instrument

    ERIC Educational Resources Information Center

    van Aalderen-Smeets, Sandra; Walma van der Molen, Juliette

    2013-01-01

    In this article, we present a valid and reliable instrument which measures the attitude of in-service and pre-service primary teachers toward teaching science, called the Dimensions of Attitude Toward Science (DAS) Instrument. Attention to the attitudes of primary teachers toward teaching science is of fundamental importance to the…

  7. Elevated Background in DAS-I ELISA for the Detection of Citrus Tristeza Virus in Mandarin Varieties

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Healthy tissue extracts from mandarin orange varieties occasionally resulted in elevated absorbance which can exceed twice that of healthy sweet orange tissue extracts in DAS-I-ELISA detection with an expressed coat protein polyclonal antiserum of Citrus tristeza virus (CTV). This problem occurs se...

  8. Crystal Structures of the Global Regulator DasR from Streptomyces coelicolor: Implications for the Allosteric Regulation of GntR/HutC Repressors

    PubMed Central

    Fillenberg, Simon B.; Friess, Mario D.; Körner, Samuel; Böckmann, Rainer A.; Muller, Yves A.

    2016-01-01

    Small molecule effectors regulate gene transcription in bacteria by altering the DNA-binding affinities of specific repressor proteins. Although the GntR proteins represent a large family of bacterial repressors, only little is known about the allosteric mechanism that enables their function. DasR from Streptomyces coelicolor belongs to the GntR/HutC subfamily and specifically recognises operators termed DasR-responsive elements (dre-sites). Its DNA-binding properties are modulated by phosphorylated sugars. Here, we present several crystal structures of DasR, namely of dimeric full-length DasR in the absence of any effector and of only the effector-binding domain (EBD) of DasR without effector or in complex with glucosamine-6-phosphate (GlcN-6-P) and N-acetylglucosamine-6-phosphate (GlcNAc-6-P). Together with molecular dynamics (MD) simulations and a comparison with other GntR/HutC family members these data allowed for a structural characterisation of the different functional states of DasR. Allostery in DasR and possibly in many other GntR/HutC family members is best described by a conformational selection model. In ligand-free DasR, an increased flexibility in the EBDs enables the attached DNA-binding domains (DBD) to sample a variety of different orientations and among these also a DNA-binding competent conformation. Effector binding to the EBDs of DasR significantly reorganises the atomic structure of the latter. However, rather than locking the orientation of the DBDs, the effector-induced formation of β-strand β* in the DBD-EBD-linker segment merely appears to take the DBDs ‘on a shorter leash’ thereby impeding the ‘downwards’ positioning of the DBDs that is necessary for a concerted binding of two DBDs of DasR to operator DNA. PMID:27337024

  9. Parallel Proportion Fair Scheduling in DAS with Partial Channel State Information

    NASA Astrophysics Data System (ADS)

    Jiang, Zhanjun; Wu, Jiang; Wang, Dongming; You, Xiaohu

    A parallel multiplexing scheduling (PMS) scheme is proposed for distributed antenna systems (DAS), which greatly improves average system throughput due to multi-user diversity and multi-user multiplexing. However, PMS has poor fairness because of the use of the “best channel selection” criteria in the scheduler. Thus we present a parallel proportional fair scheduling (PPFS) scheme, which combines PMS with proportional fair scheduling (PFS) to achieve a tradeoff between average throughput and fairness. In PPFS, the “relative signal to noise ratio (SNR)” is employed as a metric to select the user instead of the “relative throughput” in the original PFS. And only partial channel state information (CSI) is fed back to the base station (BS) in PPFS. Moreover, there are multiple users selected to transmit simultaneously at each slot in PPFS, while only one user occupies all channel resources at each slot in PFS. Consequently, PPFS improves fairness performance of PMS greatly with a relatively small loss of average throughput compared to PFS.

  10. Common Data Acquisition Systems (DAS) Software Development for Rocket Propulsion Test (RPT) Test Facilities

    NASA Technical Reports Server (NTRS)

    Hebert, Phillip W., Sr.; Davis, Dawn M.; Turowski, Mark P.; Holladay, Wendy T.; Hughes, Mark S.

    2012-01-01

    The advent of the commercial space launch industry and NASA's more recent resumption of operation of Stennis Space Center's large test facilities after thirty years of contractor control resulted in a need for a non-proprietary data acquisition systems (DAS) software to support government and commercial testing. The software is designed for modularity and adaptability to minimize the software development effort for current and future data systems. An additional benefit of the software's architecture is its ability to easily migrate to other testing facilities thus providing future commonality across Stennis. Adapting the software to other Rocket Propulsion Test (RPT) Centers such as MSFC, White Sands, and Plumbrook Station would provide additional commonality and help reduce testing costs for NASA. Ultimately, the software provides the government with unlimited rights and guarantees privacy of data to commercial entities. The project engaged all RPT Centers and NASA's Independent Verification & Validation facility to enhance product quality. The design consists of a translation layer which provides the transparency of the software application layers to underlying hardware regardless of test facility location and a flexible and easily accessible database. This presentation addresses system technical design, issues encountered, and the status of Stennis development and deployment.

  11. Die grünende IT - Wie die Computerindustrie das Energiesparen neu erfand

    NASA Astrophysics Data System (ADS)

    von Greiner, Wilhelm

    Die IT-Branche hat ihr grünes Gewissen entdeckt. In der jetzigen Verbreitung und Intensität ist dieses Phänomen noch recht neu - lange Zeit schien die Informationstechnik in puncto Umweltverträglichkeit und Energieverbrauch eine "weiße Weste" zu haben. Schließlich läuft ein PC mit Strom und nicht mit - sagen wir mal - einem Dieselmotor: Beim Booten eines Computers schießt nicht erst eine dunkelgraue Rauchwolke aus dem Auspuff, die Lärmerzeugung beschränkt sich auf das Surren des Lüfters, zum Tanken fahren muss man mit ihm auch nicht, und die Produktion der Komponenten erfolgt… ja, wo eigentlich? Irgendwo in der "dritten Welt", in Fernost oder in Mexiko. So sind die umweltschädlichen Aspekte der Produktion von Leiterplatten und sonstigen Bauteilen aus den Augen, aus dem Sinn und bestenfalls sporadisch Gegenstand eines kritischen Greenpeace-Berichts1, der im Überangebot der Medienlandschaft untergeht.

  12. An initial test of an Intelligent Distributed Acoustic Sensing (iDAS) in the ice in Lake Mendota

    NASA Astrophysics Data System (ADS)

    Castongia, E.; Fratta, D.; Wang, H. F.; Mondanos, M.; Chalari, A.

    2013-12-01

    A Distributed Acoustic Sensor (DAS) was deployed to assess wave propagation detection in ice using fiber-optic cable. The acoustic field is sensed continuously along an optical fiber cable by interrogating it with pulses of light. The Sensor (iDAS manufactured by Silixa) samples the coupled medium as to the fiber, as waves travel through the medium, at several kilohertz along every meter of the cable. In March 2012 measurements were carried out along a triangular shaped array on the frozen surface of Lake Mendota. The purpose of the test was to assess the applicability of DAS to determine near surface geophysical properties from its unique way of measuring acoustic fields. We constructed an equilateral triangle array with a side length of 30 meters by freezing optical fiber cables into the sub surface layer of the ice which ranged in thickness between 15 to 20 cm. The fiber cables were frozen to a depth of about 10 cm to achieve uniform cable-ice coupling. The cable sensor was continuous and was looped about 4 times around to get multiple readings at each sampling location, and resulted in a total cable length of about 445 meters. Two different cable constructions were tested. The first type was of tight-buffered central stainless steel capillary tube and the second type of steel-reinforced central stainless steel loose tube. Seismic shots were generated using a sledge hammer and steel plate. Various shot sequences were taken along three different directions to assess the response and sensitivity of the system. A vertical geophone array was also deployed for a reference measurement every 5 meters along each of the sides of the triangle. Every 10 meters, the vertical geophones were complemented by two horizontal geophones. Analysis of the data showed that wavefronts of first arrivals were clearly visible from even the furthest shot location which enabled calculations of properties of the ice as the wavefronts traveled through it. Differences in sign in the recorded

  13. MiDas: Automatic Extraction of a Common Domain of Discourse in Sleep Medicine for Multi-center Data Integration

    PubMed Central

    Sahoo, Satya S.; Ogbuji, Chimezie; Luo, Lingyun; Dong, Xiao; Cui, Licong; Redline, Susan S.; Zhang, Guo-Qiang

    2011-01-01

    Clinical studies often use data dictionaries with controlled sets of terms to facilitate data collection, limited interoperability and sharing at a local site. Multi-center retrospective clinical studies require that these data dictionaries, originating from individual participating centers, be harmonized in preparation for the integration of the corresponding clinical research data. Domain ontologies are often used to facilitate multi-center data integration by modeling terms from data dictionaries in a logic-based language, but interoperability among domain ontologies (using automated techniques) is an unresolved issue. Although many upper-level reference ontologies have been proposed to address this challenge, our experience in integrating multi-center sleep medicine data highlights the need for an upper level ontology that models a common set of terms at multiple-levels of abstraction, which is not covered by the existing upper-level ontologies. We introduce a methodology underpinned by a Minimal Domain of Discourse (MiDas) algorithm to automatically extract a minimal common domain of discourse (upper-domain ontology) from an existing domain ontology. Using the Multi-Modality, Multi-Resource Environment for Physiological and Clinical Research (Physio-MIMI) multi-center project in sleep medicine as a use case, we demonstrate the use of MiDas in extracting a minimal domain of discourse for sleep medicine, from Physio-MIMI’s Sleep Domain Ontology (SDO). We then extend the resulting domain of discourse with terms from the data dictionary of the Sleep Heart and Health Study (SHHS) to validate MiDas. To illustrate the wider applicability of MiDas, we automatically extract the respective domains of discourse from 6 sample domain ontologies from the National Center for Biomedical Ontologies (NCBO) and the OBO Foundry. PMID:22195180

  14. MiDas: automatic extraction of a common domain of discourse in sleep medicine for multi-center data integration.

    PubMed

    Sahoo, Satya S; Ogbuji, Chimezie; Luo, Lingyun; Dong, Xiao; Cui, Licong; Redline, Susan S; Zhang, Guo-Qiang

    2011-01-01

    Clinical studies often use data dictionaries with controlled sets of terms to facilitate data collection, limited interoperability and sharing at a local site. Multi-center retrospective clinical studies require that these data dictionaries, originating from individual participating centers, be harmonized in preparation for the integration of the corresponding clinical research data. Domain ontologies are often used to facilitate multi-center data integration by modeling terms from data dictionaries in a logic-based language, but interoperability among domain ontologies (using automated techniques) is an unresolved issue. Although many upper-level reference ontologies have been proposed to address this challenge, our experience in integrating multi-center sleep medicine data highlights the need for an upper level ontology that models a common set of terms at multiple-levels of abstraction, which is not covered by the existing upper-level ontologies. We introduce a methodology underpinned by a Minimal Domain of Discourse (MiDas) algorithm to automatically extract a minimal common domain of discourse (upper-domain ontology) from an existing domain ontology. Using the Multi-Modality, Multi-Resource Environment for Physiological and Clinical Research (Physio-MIMI) multi-center project in sleep medicine as a use case, we demonstrate the use of MiDas in extracting a minimal domain of discourse for sleep medicine, from Physio-MIMI's Sleep Domain Ontology (SDO). We then extend the resulting domain of discourse with terms from the data dictionary of the Sleep Heart and Health Study (SHHS) to validate MiDas. To illustrate the wider applicability of MiDas, we automatically extract the respective domains of discourse from 6 sample domain ontologies from the National Center for Biomedical Ontologies (NCBO) and the OBO Foundry. PMID:22195180

  15. Sensitivity of Global Modeling Initiative CTM predictions of Antarctic ozone recovery to GCM and DAS generated meteorological fields

    SciTech Connect

    Rotman, D; Bergmann, D

    2003-12-04

    We use the Global Modeling Initiative chemistry and transport model to simulate the evolution of stratospheric ozone between 1995 and 2030, using boundary conditions consistent with the recent World Meteorological Organization ozone assessment. We compare the Antarctic ozone recovery predictions of two simulations, one driven by meteorological data from a general circulation model (GCM), the other using the output of a data assimilation system (DAS), to examine the sensitivity of Antarctic ozone recovery predictions to the characteristic dynamical differences between GCM and DAS-generated meteorological data. Although the age of air in the Antarctic lower stratosphere differs by a factor of 2 between the simulations, we find little sensitivity of the 1995-2030 Antarctic ozone recovery between 350 K and 650 K to the differing meteorological fields, particularly when the recovery is specified in mixing ratio units. Relative changes are smaller in the DAS-driven simulation compared to the GCM-driven simulation due to a surplus of Antarctic ozone in the DAS-driven simulation which is not consistent with observations. The peak ozone change between 1995 and 2030 in both simulations is {approx}20% lower than photochemical expectations, indicating that changes in ozone transport at 450 K between 1995 and 2030 constitute a small negative feedback. Total winter/spring ozone loss during the base year (1995) of both simulations and the rate of ozone loss during August and September is somewhat weaker than observed. This appears to be due to underestimates of Antarctic Cl{sub y} at the 450 K potential temperature level.

  16. Verknüpfung von DQ-Indikatoren mit KPIs und Auswirkungen auf das Return on Investment

    NASA Astrophysics Data System (ADS)

    Block, Frank

    Häufig ist nicht klar, welche Beziehungen zwischen Datenqualitätsindikatoren (DQI, Definition folgt weiter unten) und Key Performance Indicators (KPI, s. Abschnitt 1.3 für weitere Details) eines Unternehmens oder einer Organisation bestehen. Dies ist insbesondere deshalb von Bedeutung, da die Kenntnis dieser Beziehungen maßgeblich die Ausprägung eines Datenqualitätsprojekts beeinflusst. Sie ist als Entscheidungsgrundlage unabdingbar und gibt Antworten auf folgende Fragen: Was kostet unserem Unternehmen/unserer Organisation1 schlechte Datenqualität? Können wir uns das leisten?

  17. Efficacy of Soybean's Event DAS-81419-2 Expressing Cry1F and Cry1Ac to Manage Key Tropical Lepidopteran Pests Under Field Conditions in Brazil.

    PubMed

    Marques, L H; Castro, B A; Rossetto, J; Silva, O A B N; Moscardini, V F; Zobiole, L H S; Santos, A C; Valverde-Garcia, P; Babcock, J M; Rule, D M; Fernandes, O A

    2016-08-01

    Bacillus thuringiensis (Bt) event DAS-81419-2 (Conkesta technology) in soybean, Glycine max (L.) Merrill, expresses Cry1F and Cry1Ac proteins to provide protection from feeding by several lepidopteran pests. A total of 27 field experiments across nine locations were conducted from 2011 to 2015 in southern and central Brazil to characterize the efficacy of DAS-81419-2 soybean infested with Anticarsia gemmatalis Hübner (Lepidoptera: Erebidae), Chrysodeixis includens (Walker) (Lepidoptera: Noctuidae), Heliothis virescens (F.) (Lepidoptera: Noctuidae), and Spodoptera cosmioides (Walker) (Lepidoptera: Noctuidae) during vegetative (V4) and reproductive (R2 and R4) crop developmental stages. The efficacy of DAS-81419-2 was compared to that of a non-Bt isogenic variety managed with or without applications of commercial foliar insecticides for lepidopteran control. DAS-81419-2 soybean consistently experienced defoliation levels of 0.5% or less (compared with 20.05-56.74% in the non-Bt, nonsprayed treatment) and larval survival of < 0.1% in all four species across the vegetative and reproductive plant stages evaluated. The efficacy of DAS-81419-2 was significantly higher than commercial foliar insecticides applied to the non-Bt variety. DAS-81419-2 soybeans containing two highly effective Bt proteins are expected to be a more robust IRM tool compared to single-trait Bt technologies. The consistent efficacy of DAS-81419-2 soybeans across years, locations, and crop stages suggests that it will be a valuable product for management of hard-to-control key lepidopteran pests in South American soybean production. PMID:27401112

  18. Insect-Protected Event DAS-81419-2 Soybean (Glycine max L.) Grown in the United States and Brazil Is Compositionally Equivalent to Nontransgenic Soybean

    PubMed Central

    2015-01-01

    The transgenic soybean event DAS-81419-2 contains genes that encode the Cry1F, Cry1Ac, and PAT proteins. Cry1F and Cry1Ac provide protection against key lepidopteran insect pests, while PAT confers tolerance to the herbicide glufosinate. To satisfy regulatory requirements for the safety evaluation of transgenic crops, studies were conducted in the United States and Brazil to evaluate the nutrient and antinutrient composition of event DAS-81419-2 soybean. On the basis of the results of these studies, event DAS-81419-2 soybean is compositionally equivalent to nontransgenic soybean. This conclusion concurs with numerous other published studies in soybean and other crops where compositional equivalence between the transgenic crop and its nontransgenic comparator has been demonstrated. PMID:25641393

  19. Insect-protected event DAS-81419-2 soybean (Glycine max L.) grown in the United States and Brazil is compositionally equivalent to nontransgenic soybean.

    PubMed

    Fast, Brandon J; Schafer, Ariane C; Johnson, Tempest Y; Potts, Brian L; Herman, Rod A

    2015-02-25

    The transgenic soybean event DAS-81419-2 contains genes that encode the Cry1F, Cry1Ac, and PAT proteins. Cry1F and Cry1Ac provide protection against key lepidopteran insect pests, while PAT confers tolerance to the herbicide glufosinate. To satisfy regulatory requirements for the safety evaluation of transgenic crops, studies were conducted in the United States and Brazil to evaluate the nutrient and antinutrient composition of event DAS-81419-2 soybean. On the basis of the results of these studies, event DAS-81419-2 soybean is compositionally equivalent to nontransgenic soybean. This conclusion concurs with numerous other published studies in soybean and other crops where compositional equivalence between the transgenic crop and its nontransgenic comparator has been demonstrated. PMID:25641393

  20. Properties of Noise Cross Correlation Functions Obtained from a Distributed Acoustic Sensing (DAS) Array at Garner Valley, California

    NASA Astrophysics Data System (ADS)

    Zeng, X.; Lancelle, C.; Thurber, C. H.; Fratta, D.; Wang, H. F.; Chalari, A.; Clarke, A.

    2015-12-01

    The field test of Distributed Acoustic Sensing (DAS) conducted at Garner Valley, California on September 11-12, 2013 provided a continuous overnight record of ambient noise. The DAS array recorded ground motions every one meter of optical cable that was arranged approximately in the shape of a rectangle with dimensions of 160 m by 80 m. The long dimension of the array was adjacent to a state highway. Three hours of record were used to compute noise cross-correlation functions (NCFs) in one-minute windows. The trace from each sensor channel was pre-processed by downsampling to 200 Hz, followed by normalization in the time-domain and bandpass filtering between 2 and 20 Hz (Bensen et al., 2007). The one-minute NCFs were then stacked using the time-frequency domain phase-weighted stacking method (Schimmel & Gallart, 2007). The NCFs between channels were asymmetrical reflecting the direction of traffic noise. The group velocities were found using the frequency-time analysis method. The energy was concentrated between 5 and 15 Hz, which falls into the typical traffic noise frequency band. The resulting velocities were between 100 and 300 m/s for frequencies between 10 and 20 Hz, which are in the same range as described in the results for surface-wave dispersion obtained using an active source for the same site (Lancelle et al., 2015). The group velocity starts to decrease for frequencies greater than ~10 Hz, which was expected on the basis of a previous shear-wave velocity model (Steidl et al., 1996). Then, the phase velocity was calculated using the multichannel analysis of surface wave technique (MASW - Park et al., 1999) with 114 NCFs spaced one meter apart. The resulting dispersion curve between 5 and 15 Hz gave phase velocities that ranged from approximately 170 m/s at 15 Hz to 250 m/s at 5 Hz. These results are consistent with other results of active-source DAS and seismometer records obtained at the Garner Valley site (e.g., Stokoe et al. 2004). This analysis is

  1. Variações nos períodos de pulsação das estrelas PG 1159-035 e G117-B15-A

    NASA Astrophysics Data System (ADS)

    Costa, J. E. S.; Kepler, S. O.

    2003-08-01

    A medida que uma estrela evolui, sua trajetória no diagrama-HR passa pelas chamadas "faixas de instabilidade" podendo tornar-se uma variável. Ao longo da seqüência das anãs brancas existem três faixas de instabilidade, contando com a faixa das pré-anãs brancas (DOs). Estrelas nestas faixas podem apresentar pulsações não-radiais com períodos bastante estáveis, ente 100 e 1000 segundos. Os períodos de pulsação sofrem variações com a evolução da estrela, podendo aumentar ou diminuir. As DOs, por serem mais quentes evoluem mais rapidamente e isto faz com que as variações em seus períodos de pulsação sejam maiores (em magnitude) do que as variações que ocorrem nos períodos de pulsação de anãs brancas pulsantes mais frias como as DBs e as DAs. Neste trabalho apresentamos os resultados das medidas das variações de períodos de pulsação de duas estrelas: a PG 1159-035 e a G117-B15-A. Essas duas estrelas estão nos extremos da seqüência das anãs brancas: a PG 1159-035 é uma pré-anã branca (DO) e seus períodos de pulsação variam na ordem de 1 segundo a cada 3000 anos. Já a G117-B15-A é uma DA e seus períodos de pulsação variam cerca de 1 segundo a cada 30 milhões de anos.

  2. Landeskunde durch Weinkunde: A Taste of German Culture.

    ERIC Educational Resources Information Center

    Peacock, Dennis E.

    1978-01-01

    Describes a cultural unit centered on German wines. After a series of preparatory lessons showing how the topic touches on geography, history, and social customs, the unit culminated in a wine tasting. (EJS)

  3. Compositional equivalence of DAS-444Ø6-6 (AAD-12 + 2mEPSPS + PAT) herbicide-tolerant soybean and nontransgenic soybean.

    PubMed

    Lepping, Miles D; Herman, Rod A; Potts, Brian L

    2013-11-20

    Soybeans from transgenic event DAS-444Ø6-6 are the first to express three proteins that provide tolerance to broad-spectrum herbicides. DAS-444Ø6-6 soybean expresses the aryloxyalkanoate dioxygenase-12 (AAD-12) enzyme from the soil bacterium Delftia acidovorans , which provides tolerance to the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D); the double-mutant 5-enolpyruvylshikimate-3-phosphate synthase (2mEPSPS) enzyme encoded by a modified version of the epsps gene from maize ( Zea mays ), which provides tolerance to the herbicide glyphosate; and the phosphinothricin acetyltransferase (PAT) enzyme from Streptomyces viridochromogenes , which provides tolerance to the herbicide glufosinate. The purpose of this study was to determine if the nutrient and antinutrient composition of forage and grain from DAS-444Ø6-6 soybean are similar to those of nontransgenic soybean. Forage was analyzed for proximates, fiber, and minerals; grain analyses further included vitamins, amino acid and fatty acid profiles, and antinutrients and bioactive components (lectin, phytic acid, raffinose, stachyose, trypsin inhibitor, and isoflavones). Results indicate that DAS-444Ø6-6 soybean is compositionally equivalent to nontransgenic soybean. Findings are consistent with similar studies for other input traits, as endogenous plant metabolic pathways that influence composition are expected to be less affected by transgenesis compared with traditional plant-breeding methods. PMID:24191699

  4. Development and evaluation of a DAS-ELISA for rapid detection of Tembusu virus using monoclonal antibodies against the envelope protein.

    PubMed

    Chen, Hao; Ou, Quanbin; Tang, Yi; Gao, Xuhui; Wu, Lili; Xue, Cong; Yu, Chunmei; Cui, Jingteng; Diao, Youxiang

    2014-01-01

    Since April 2010, Tembusu virus (TMUV) which is a contagious pathogen of waterfowls, causing symptoms of high fever, loss of appetite and fall in egg production, has been reported in east of China. A double antibody sandwich enzyme-linked immunosorbent assay (DAS-ELISA) which detects for TMUV was developed, using two monoclonal antibodies (mAbs) against the TMUV envelope (E) protein. BALB/c mice were immunized with purified recombinant E protein expressed in E. coli. Three hybridoma cell lines designated as 12B1, 10C6 and 2D2, were screened by cell fusion and indirect ELISA for their ability to recognize different linear epitopes on the E protein, and were characterized subsequently. High-affinity mAbs 12B1 and 2D2 were used as capture and detection antibodies, respectively. The reaction conditions for the DAS-ELISA were optimized for TMUV detection. The cross-reactivity of the DAS-ELISA was determined using TMUV, duck plague virus, avian influenza virus subtype H9, Newcastle disease virus, duck hepatitis A virus type 1 and duck reovirus samples. A total of 191 homogenized tissues of field samples were simultaneously detected by DAS-ELISA and by RT-PCR. The former was found to have a high specificity of 99.1% and a sensitivity of 93.1%. These results reveal a positive coincidence between DAS-ELISA and RT-PCR at a coincidence rate of 95.8%. The method developed in this study can be used for the diagnosis of TMUV infection of duck origin. PMID:24797141

  5. Development and Evaluation of a DAS-ELISA for Rapid Detection of Tembusu Virus Using Monoclonal Antibodies against the Envelope Protein

    PubMed Central

    Chen, Hao; Ou, Quanbin; Tang, Yi; Gao, Xuhui; Wu, Lili; Xue, Cong; Yu, Chunmei; Cui, Jingteng; Diao, Youxiang

    2014-01-01

    Since April 2010, Tembusu virus (TMUV) which is a contagious pathogen of waterfowls, causing symptoms of high fever, loss of appetite and fall in egg production, has been reported in east of China. A double antibody sandwich enzyme-linked immunosorbent assay (DAS-ELISA) which detects for TMUV was developed, using two monoclonal antibodies (mAbs) against the TMUV envelope (E) protein. BALB/c mice were immunized with purified recombinant E protein expressed in E. coli. Three hybridoma cell lines designated as 12B1, 10C6 and 2D2, were screened by cell fusion and indirect ELISA for their ability to recognize different linear epitopes on the E protein, and were characterized subsequently. High-affinity mAbs 12B1 and 2D2 were used as capture and detection antibodies, respectively. The reaction conditions for the DAS-ELISA were optimized for TMUV detection. The cross-reactivity of the DAS-ELISA was determined using TMUV, duck plague virus, avian influenza virus subtype H9, Newcastle disease virus, duck hepatitis A virus type 1 and duck reovirus samples. A total of 191 homogenized tissues of field samples were simultaneously detected by DAS-ELISA and by RT-PCR. The former was found to have a high specificity of 99.1% and a sensitivity of 93.1%. These results reveal a positive coincidence between DAS-ELISA and RT-PCR at a coincidence rate of 95.8%. The method developed in this study can be used for the diagnosis of TMUV infection of duck origin. PMID:24797141

  6. Simulation of the single-vibronic-level emission spectra of HAsO and DAsO.

    PubMed

    Mok, Daniel K W; Lee, Edmond P F; Dyke, John M

    2016-05-14

    The single-vibronic-level (SVL) emission spectra of HAsO and DAsO have been simulated by electronic structure/Franck-Condon factor calculations to confirm the spectral molecular carrier and to investigate the electronic states involved. Various multi-reference (MR) methods, namely, NEVPT2 (n-electron valence state second order perturbation theory), RSPT2-F12 (explicitly correlated Rayleigh-Schrodinger second order perturbation theory), and MRCI-F12 (explicitly correlated multi-reference configuration interaction) were employed to compute the geometries and relative electronic energies for the X̃(1)A(') and Ã(1)A(″) states of HAsO. These are the highest level calculations on these states yet reported. The MRCI-F12 method gives computed T0 (adiabatic transition energy including zero-point energy correction) values, which agree well with the available experimental T0 value much better than previously computed values and values computed with other MR methods in this work. In addition, the potential energy surfaces of the X̃(1)A(') and Ã(1)A(″) states of HAsO were computed using the MRCI-F12 method. Franck-Condon factors between the two states, which include anharmonicity and Duschinsky rotation, were then computed and used to simulate the recently reported SVL emission spectra of HAsO and DAsO [R. Grimminger and D. J. Clouthier, J. Chem. Phys. 135, 184308 (2011)]. Our simulated SVL emission spectra confirm the assignments of the molecular carrier, the electronic states involved, and the vibrational structures observed in the SVL emission spectra but suggest a loss of intensity in the reported experimental spectra at the low emission energy region almost certainly due to a loss of responsivity near the cutoff region (∼800 nm) of the detector used. Computed and experimentally derived re (equilibrium) and/or r0 {the (0,0,0) vibrational level} geometries of the two states of HAsO are discussed. PMID:27179480

  7. Simulation of the single-vibronic-level emission spectra of HAsO and DAsO

    NASA Astrophysics Data System (ADS)

    Mok, Daniel K. W.; Lee, Edmond P. F.; Dyke, John M.

    2016-05-01

    The single-vibronic-level (SVL) emission spectra of HAsO and DAsO have been simulated by electronic structure/Franck-Condon factor calculations to confirm the spectral molecular carrier and to investigate the electronic states involved. Various multi-reference (MR) methods, namely, NEVPT2 (n-electron valence state second order perturbation theory), RSPT2-F12 (explicitly correlated Rayleigh-Schrodinger second order perturbation theory), and MRCI-F12 (explicitly correlated multi-reference configuration interaction) were employed to compute the geometries and relative electronic energies for the X ˜ 1 A ' and A ˜ 1 A ″ states of HAsO. These are the highest level calculations on these states yet reported. The MRCI-F12 method gives computed T0 (adiabatic transition energy including zero-point energy correction) values, which agree well with the available experimental T0 value much better than previously computed values and values computed with other MR methods in this work. In addition, the potential energy surfaces of the X ˜ 1 A ' and A ˜ 1 A ″ states of HAsO were computed using the MRCI-F12 method. Franck-Condon factors between the two states, which include anharmonicity and Duschinsky rotation, were then computed and used to simulate the recently reported SVL emission spectra of HAsO and DAsO [R. Grimminger and D. J. Clouthier, J. Chem. Phys. 135, 184308 (2011)]. Our simulated SVL emission spectra confirm the assignments of the molecular carrier, the electronic states involved, and the vibrational structures observed in the SVL emission spectra but suggest a loss of intensity in the reported experimental spectra at the low emission energy region almost certainly due to a loss of responsivity near the cutoff region (˜800 nm) of the detector used. Computed and experimentally derived re (equilibrium) and/or r0 {the (0,0,0) vibrational level} geometries of the two states of HAsO are discussed.

  8. Common Data Acquisition Systems (DAS) Software Development for Rocket Propulsion Test (RPT) Test Facilities - A General Overview

    NASA Technical Reports Server (NTRS)

    Hebert, Phillip W., Sr.; Hughes, Mark S.; Davis, Dawn M.; Turowski, Mark P.; Holladay, Wendy T.; Marshall, PeggL.; Duncan, Michael E.; Morris, Jon A.; Franzl, Richard W.

    2012-01-01

    The advent of the commercial space launch industry and NASA's more recent resumption of operation of Stennis Space Center's large test facilities after thirty years of contractor control resulted in a need for a non-proprietary data acquisition system (DAS) software to support government and commercial testing. The software is designed for modularity and adaptability to minimize the software development effort for current and future data systems. An additional benefit of the software's architecture is its ability to easily migrate to other testing facilities thus providing future commonality across Stennis. Adapting the software to other Rocket Propulsion Test (RPT) Centers such as MSFC, White Sands, and Plumbrook Station would provide additional commonality and help reduce testing costs for NASA. Ultimately, the software provides the government with unlimited rights and guarantees privacy of data to commercial entities. The project engaged all RPT Centers and NASA's Independent Verification & Validation facility to enhance product quality. The design consists of a translation layer which provides the transparency of the software application layers to underlying hardware regardless of test facility location and a flexible and easily accessible database. This presentation addresses system technical design, issues encountered, and the status of Stennis' development and deployment.

  9. Free convection in a parallelogrammic porous cavity filled with a nanofluid using Tiwari and Das' nanofluid model.

    PubMed

    Ghalambaz, Mohammad; Sheremet, Mikhail A; Pop, Ioan

    2015-01-01

    The free convection heat transfer of Cu-water nanofluids in a parallelogrammic enclosure filled with porous media is numerically analyzed. The bottom and top of the enclosure are insulated while the sidewalls are subject to limited temperature difference. The Darcy flow and the Tiwari and Das' nanofluid models are considered. The governing dimensionless partial differential equations are numerically solved using a finite difference code. The results are reported for isotherms and streamlines as well as Nusselt number as a function of the volume fraction of nanoparticles, porosity, types of the porous matrix, inclination angle, aspect ratio and different Rayleigh numbers. It is found that the presence of the nanoparticles inside the enclosure deteriorates the heat transfer rate, which is caused due to the increase of dynamic viscosity by the presence of nanoparticles. Therefore, in applications in which the nanofluids are used for their advantages, such as enhanced dielectric properties or antibacterial properties, more caution for the heat transfer design of the enclosure is necessary. PMID:25993540

  10. Código para imageamento indireto de estrelas em sistemas binarios: simulação de variações elipsoidais e do perfil das linhas

    NASA Astrophysics Data System (ADS)

    Souza, T. R.; Baptista, R.

    2003-08-01

    As estrelas secundárias em variáveis cataclí smicas (VCs) e binárias-x de baixa massa (BXBMs) são cruciais para o entendimento da origem, evolução e comportamento destas binárias interagentes. Elas são estrelas magneticamente ativas submetidas a condições ambientais extremas [e.g., estão muito próximas de uma fonte quente e irradiante; têm rotação extremamente rápida e forma distorcida; estão perdendo massa a taxas de 10-8-10-10 M¤/ano] que contribuem para que suas propriedades sejam distintas das de estrelas de mesma massa na seqüência principal. Por outro lado, o padrão de irradiação na face da secundária fornece informação sobre a geometria das estruturas de acréscimo em torno da estrela primária. Assim, a obtenção de imagens da superfície destas estrelas é de grande interesse astrofísico. A Tomografia Roche usa as variações no perfil das linhas de emissão/absorção da estrela secundária em função da fase orbital para mapear a distribuição de brilho em sua superfície. Neste trabalho apresentamos os resultados iniciais do desenvolvimento de um programa para o mapeamento da distribuição de brilho na superfí cie das estrelas secundárias em VCs e BXBMs com técnicas de astro-tomografia. Presentemente temos em operação um código que simula as variações no perfil das linhas em conseqüência de efeito Doppler resultante da combinação de rotação e translação de uma estrela em forma de lobo de Roche em torno do centro de massa da binária, em função da distribuição de brilho na superfície desta estrela. O código igualmente produz a curva de luz resultante das variações de aspecto da estrela em função da fase orbital (variações elipsoidais).

  11. Variation of the anthropic vulnerability in Ribeirão das Pedras watershed in Campinas/SP - Brazil.

    NASA Astrophysics Data System (ADS)

    Damame, Desirée; Longo, Regina; Ribeiro, Admilson; Fengler, Felipe

    2015-04-01

    The human actions has caused over the years profound changes in environmental quality in urban ecosystems suffering losses in the quality of air, soil , water and vegetation also the quality of life of the population that inhabit these areas . The study area is characterized by being a highly urbanized watershed, with about 43 % of its area covered by buildings, houses , and commercial and industrial establishments . Called the Ribeirão das Pedras Basin, located in Campinas / SP - Brazil and is bounded by coordinates 22˚47'10 '' and 22˚52'20 '' S , and 47˚ 07'15 '' and 46˚ 02 ' 15' ' . Has an average temperature of 22.4 ° C and average annual rainfall of 1424.5 mm . It has an area of about 42 km² . This is located two universities and a large mall. It also demands a strong agriculture , which occupies about 30 % of the area . It has also been part of two major forest reserves of the municipality, the Forest Santa Geneva and the Forest of Quilombo , both added to other small fragments overlying only about 6% of the total basin area . Avalição to environmental quality , the analysis of the vulnerability of urban watershed becomes an important environmental management tool. The vulnerability can be defined by susceptibility to changes of environment in its initial state , a current tax status by human intervention , and is almost always associated with risk , and the intensity at which such projects in one place, person or structure. In this context , this study aimed to assess environmental vulnerability in an urban watershed coming under increasing human pressures , especially in recent years . For this analysis were prepared soil graphics, slope , elevation and land use and land cover for the years 2009 and 2014 , generating with these , comparative anthropic vulnerability maps of the past five years. Crafting vulnerability maps is a sensitivity in order to enable appropriate management of biotic systems. With the results can be seen that the variation of

  12. Latent factor structure of the Das-Naglieri Cognitive Assessment System: a confirmatory factor analysis in a Chinese setting.

    PubMed

    Deng, Ci-ping; Liu, Ming; Wei, Wei; Chan, Raymond C K; Das, J P

    2011-01-01

    This study aims to measure the psychometric properties of the Das-Naglieri Cognitive Assessment System (D-N CAS) and to determine its clinical utility in a Chinese context. Confirmatory factor analysis (CFA) was conducted to examine the construct validity of the Chinese version of the D-N CAS among a group of 567, normally developed children. Test-retest reliability was examined in a random subsample of 30 children at a five-week interval. The clinical discrimination of the D-N CAS was also examined by comparing children with and without ADHD (18 children in each group) and by comparing children with and without Chinese reading disabilities (18 children in each group). The current Chinese sample demonstrated a four-factor solution for cognitive performance among children with normal development: Planning, Attention, Simultaneous processing and Successive processing (χ2(48)=91.90, p=.000; χ2/df=1.92, RMSEA=.050, GFI=.966, CFI=.954). Moreover, all subtests of the battery demonstrated acceptable test-retest reliability (r=.72-.90, p<.01) at a five-week interval among the subjects of the small subsample. Children with ADHD performed significantly worse than normal children on the Attention factor (p<.001) and the Planning factor (p<.05) of the D-N CAS, and children with Chinese reading disabilities performed significantly worse than normal children on the Simultaneous processing factor (p<.01), the Successive processing factor (p<.001) and the Planning factor (p<.05) of the D-N CAS. These findings suggested that the current four-factor structure of the D-N CAS was similar to the original factor structure of the test. The latent factor of the D-N CAS was fairly stable across the cultures. Moreover, the D-N CAS can distinguish between children with ADHD or Chinese reading disabilities and normally developed children. PMID:21571501

  13. Ventos em supergigantes B[e] das nuvens de Magalhães e da Galáxia

    NASA Astrophysics Data System (ADS)

    de Araújo, F. X.; Pilling, D. A.; Pereira, C. B.; Fernandes, M. B.

    2003-08-01

    As Supergigantes B[e] apresentam as seguintes características: (i) alta luminosidade; (ii) espectro típico de estrelas de tipo B; (iii) linhas permitidas e proibidas em emissão de metais de baixa ionização, especialmente FeII; (iv) linhas de Balmer, e por vêzes também dos ions HeI e FeII, com perfis tipo P Cygni indicativos de altas taxas de perda de massa. Atualmente estamos desenvolvendo um projeto que visa comparar as propriedades fisicas (principalmente e v¥) dos ventos destes objetos nas Nuvens de Magalhães e na Galaxia. O objetivo é estudar a influência da metalicidade. No presente painel apresentamos uma determinação das velocidades terminais de 11 estrelas, sendo 4 na GNM (Hen S111, 66, R126 e Hen S93), 4 na PNM (Hen S18, S23, S65 e R4) e 3 na Galaxia (CPD-529243, MWC 300 e GG Car). Nossos dados são espectros de alta resolução obtidos no telescópio 1.52m do ESO com o espectrógrafo FEROS. Para determinar as velocidades terminais usamos as linhas Hd e HeI 3888 Å cujas componentes em absorção costumam estar livres de "blends" e estruturas. Nossos resultados sugerem que as velocidades de expansão na GNM são maiores (ainda que apenas ligeiramente) do que aquelas da PNM, como esperado. No entanto, os objetos da Galaxia não parecem seguir a mesma tendência.

  14. Ultrasound Findings in Hand Joints Involvement in Patients with Psoriatic Arthritis and Its Correlation with Clinical DAS28 Score

    PubMed Central

    Naranje, Priyanka; Prakash, Mahesh; Sharma, Aman; Dogra, Sunil; Khandelwal, Niranjan

    2015-01-01

    Objective. To determine the frequency of the various ultrasound findings in hand joints in patients with psoriatic arthritis and correlate grayscale and Power Doppler ultrasonography findings with Disease Activity Score 28. Methods. This prospective study was performed in 30 patients. Ultrasound evaluation of 28 joints of both hands was undertaken and various findings were recorded including synovial hypertrophy, Power Doppler abnormality, soft tissue thickening, tendonitis, joint effusion, periosteal reaction, and erosions. Composite ultrasound scores and Disease Activity Score 28 were calculated and compared. Spearman correlation was used to see relationship between the ultrasound and DAS28 scores. Results. Ultrasound detected more abnormalities in the hand joints than did clinical examination. The frequency of various ultrasound abnormalities was as follows: Synovial hypertrophy was seen in 100%, Power Doppler abnormality suggesting hypervascularity was seen in 36.7%, soft tissue thickening was seen in 66.7%, periosteal reaction was seen in 33.3%, erosions were seen in 30% (mostly in DIP and PIP joints), and flexor tendonitis was seen in 6.7% of patients. Significant correlation was found between Disease Activity Score 28 and grayscale joint score (GSJS) (Spearman's ρ: 0.499; P: 0.005), grayscale joint count (GSJC) (ρ: 0.398; P: 0.029), and Power Doppler joint score (PDJS) (ρ: 0.367; P: 0.046). There was a statistically significant difference between remission and low disease activity group and moderate disease activity group in terms of GSJC, GSJS, PDJC, and PDJS (P < 0.05). These ultrasound measures were higher in moderate disease activity zone patients. Conclusion. Ultrasound is a useful modality for the objective assessment of psoriatic arthritis. Ultrasound including Power Doppler can be used as a modality for assessment of severity of psoriatic arthritis as it correlates with the clinical scoring. PMID:26858846

  15. Europäisches Organ der Festkörperforschung und DDR-Devisenbringer Die Zeitschrift Physica Status Solidi im Kalten Krieg

    NASA Astrophysics Data System (ADS)

    Hoffmann, Dieter

    Mit dem Ziele, ein einheitliches internationales Organ der Festkörperphysik für den europäischen Raum zu schaffen, das eine rasche Publikation der für das Festkörpergebiet repräsentative Arbeiten ermöglicht, wird durch ein internationales Herausgebergremium eine neue wissenschaftliche Zeitschrift gegründet.

  16. Soil gas Rn monitoring at Chã das Caldeiras prior the 2014-15 Fogo eruption, Cape Verde

    NASA Astrophysics Data System (ADS)

    Padilla, Germán; Barrancos, José; Dionis, Samara; Fernandes, Paulo; Pérez, Nemesio M.; Sagiya, Takeshi; Padrón, Eleazar; Melián, Gladys V.; Hernández, Pedro A.; Silva, Sónia; Pereira, José Manuel; Rodríguez, Fátima; Asensio-Ramos, María; Calvo, David; Semedo, Helio

    2015-04-01

    Since 2007 the ITER-INVOLCAN/UNICV-OVCV/SNPC research team has implemented a geochemical program for the volcanic surveillance of Fogo volcano by means of applying different geochemical methods in a regularly basis (diffuse degassing surveys, fumarole gas sampling, etc.). This program was improved by setting up a geochemical permanent station (CHA01) to perform continuous measurements of soil gas radon (222Rn) and thoron (220Rn) activities at Chã das Caldeiras, more specific in Portela village, since April 20, 2013. Both gases are characterized to ascend towards the surface mainly through cracks or faults via diffusion and/or advection mechanisms dependent of both soil porosity and permeability, which in turn vary as a function of the stress/strain changes at depth. Measurements of 222Rn and 220Rn activities were performed by an alpha-spectrometer after pumping the soil gas from a thermally isolated PVC pipe inserted 1m in the ground. Even though during the study period the recorded data did not show high 222Rn activity values, a change in the temporal evolution of soil gas 222Rn activity was observed. During the first six months, from April to October, 2013, recorded time series of 222Rn and 220Rn activities showed normal background levels with values of 80.5 and 55.2 Bqm-3, respectively. However, from October, 2013, to February, 2014, 222Rn time series showed an increase trend reaching peak values of 396 Bqm-3 and having an average activity of 134 Bqm-3 until the removal of the station on November 25, 2014 due to the potential danger of being destroyed by the lava flows. The observed increase in the soil gas 222Rn activity from October 2013 to February 2014 occurs almost at the same time of slight observed changes in the vertical displacements detected by the geodetic network installed at the Fogo Island by the ITER-INVOLCAN/UNICV-OVCV/SNPC/Nagoya University research team. Since seismic data are not available, we cannot conclude if the observed changes in soil

  17. Desenvolvimento das câmeras de raios-X duros do satélite MIRAX

    NASA Astrophysics Data System (ADS)

    Braga, J.; Rothschild, R.; Staubert, R.; Heise, J.; Remillard, R.; D'Amico, F.; Jablonski, F.; Mejía, J.; Carvalho, H.; Heindl, B.; Matteson, J.; Kendziorra, E.; Wilms, J.; in't Zand, J.; Kuulkers, E.

    2003-08-01

    O MIRAX (Monitor e Imageador de RAios-X) é um projeto de desenvolvimento de um pequeno satélite astronômico de raios-X (~200 kg, ~240 W). A estratégia básica da missão será observar continuamente (~9 meses por ano) a região central (~1000 graus2) do plano Galáctico e realizar estudos espectroscópicos de banda larga (2-200 keV) e alta sensibilidade de um grande conjunto de fontes através de imagens com resolução de ~6'. Isso proporcionará uma cobertura inédita do "espaço de descobertas" através da detecção, localização, identificação e estudo detalhado de fenômenos imprevisíveis, tais como transientes fracos de raios-X, novas rápidas de raios-X e bursts de raios gama, assim como o estudo de fontes com emissão persistente. Neste trabalho apresentamos o projeto das duas câmeras de raios-X duros (CXDs) do MIRAX, que irão operar na faixa de 10 a 200 keV. Cada CXD consistirá de um plano de detectores CZT (Cd0,9Zn0,1Te) de 0,5 mm de resolução espacial e 370 cm2 de área total, e de uma máscara codificada com elementos quadrados de 1,3 mm de lado e 0,5 cm de espessura. A máscara terá dimensões de 315 cm ´ 275 cm e será montada a 700 cm de distância dos detectores. Com essa configuração as CXDs terão 6' de resolução angular e, quando colocadas a um ângulo de 29° entre si, as duas câmeras propiciam um campo totalmente codificado de 39° ´ 6°12' e um campo total de 76° ´ 44°. Serão apresentadas simulações de observações da região do plano Galáctico com o conjunto formado pelas duas CXDs.

  18. The Microbial Database for Danish wastewater treatment plants with nutrient removal (MiDas-DK) - a tool for understanding activated sludge population dynamics and community stability.

    PubMed

    Mielczarek, A T; Saunders, A M; Larsen, P; Albertsen, M; Stevenson, M; Nielsen, J L; Nielsen, P H

    2013-01-01

    Since 2006 more than 50 Danish full-scale wastewater treatment plants with nutrient removal have been investigated in a project called 'The Microbial Database for Danish Activated Sludge Wastewater Treatment Plants with Nutrient Removal (MiDas-DK)'. Comprehensive sets of samples have been collected, analyzed and associated with extensive operational data from the plants. The community composition was analyzed by quantitative fluorescence in situ hybridization (FISH) supported by 16S rRNA amplicon sequencing and deep metagenomics. MiDas-DK has been a powerful tool to study the complex activated sludge ecosystems, and, besides many scientific articles on fundamental issues on mixed communities encompassing nitrifiers, denitrifiers, bacteria involved in P-removal, hydrolysis, fermentation, and foaming, the project has provided results that can be used to optimize the operation of full-scale plants and carry out trouble-shooting. A core microbial community has been defined comprising the majority of microorganisms present in the plants. Time series have been established, providing an overview of temporal variations in the different plants. Interestingly, although most microorganisms were present in all plants, there seemed to be plant-specific factors that controlled the population composition thereby keeping it unique in each plant over time. Statistical analyses of FISH and operational data revealed some correlations, but less than expected. MiDas-DK (www.midasdk.dk) will continue over the next years and we hope the approach can inspire others to make similar projects in other parts of the world to get a more comprehensive understanding of microbial communities in wastewater engineering. PMID:23752384

  19. Data Integration Acquired from Micro-Uav and Terrestrial Laser Scanner for the 3d Mapping of Jesuit Ruins of São Miguel das Missões

    NASA Astrophysics Data System (ADS)

    Reiss, M. L. L.; da Rocha, R. S.; Ferraz, R. S.; Cruz, V. C.; Morador, L. Q.; Yamawaki, M. K.; Rodrigues, E. L. S.; Cole, J. O.; Mezzomo, W.

    2016-06-01

    The Jesuit Missions the Guaranis were one of the great examples of cultural, social, and scientific of the eighteenth century, which had its decline from successive wars that followed the exchange of territories domain occupied by Portugal and Spain with the Madrid Treaty of January 13, 1750. One of the great examples of this development is materialized in the ruins of 30 churches and villages that remain in a territory that now comprises part of Brazil, Argentina and Paraguay. These Churches, São Miguel das Missões is among the Brazilian ruins, the best preserved. The ruins of São Miguel das Missões were declared a UNESCO World Cultural Heritage in 1983 and the Institute of National Historical Heritage (IPHAN) is the Brazilian Federal agency that manages and maintains this heritage. In order to produce a geographic database to assist the IPHAN in the management of the Ruins of São Miguel das Missões it was proposed a three-dimensional mapping of these ruins never performed in this location before. The proposal is integrated data acquired from multiple sensors: two micro-UAV, an Asctec Falcon 8 (rotary wing) and a Sensefly e-Bee (fixed wing); photos from terrestrial cameras; two terrestrial LIDAR sensors, one Faro Focus 3D S-120 and Optec 3D-HD ILRIS. With this abundance of sensors has been possible to perform comparisons and integration of the acquired data, and produce a 3D reconstruction of the church with high completeness and accuracy (better than 25 mm), as can be seen in the presentation of this work.

  20. Challenges for bathing in rivers in terms of compliance with coliform standards. Case study in a large urbanized basin (das Velhas River, Brazil).

    PubMed

    von Sperling, Marcos; von Sperling, Eduardo

    2013-01-01

    This paper presents a case study on the prospects of bathing in a large water course (das Velhas River, Brazil), which crosses the important metropolitan region of Belo Horizonte (25 municipalities), receiving several point and diffuse discharges. The studies were carried out based on a mathematical simulation of thermotolerant coliforms over 227 km of the river, using an adaptation of the Qual2E model (model Qual-UFMG). Simulations of intervention scenarios were made for the current conditions, with three reference flows for the das Velhas River, tributaries and direct contribution: Q7,10 (representative of low-flow conditions), Q50 (average conditions) and Q10 (rainy season). The intervention scenarios simulated were: (a) current conditions without intervention; (b) scenario with effluent disinfection in the two largest wastewater treatment plants in the basin (around 2.4 million inhabitants); (c) scenario with 95% sewage collection and treatment, with disinfection in all municipalities of the study area; (d) scenario with the calculation of values required for the coverage of sewage treatment and coliform removal efficiencies based on a mathematical optimization process. The monitoring data and results of all simulations indicated improvement in coliform concentration as the river flows downstream. However, results suggested that disinfection per se is not enough. Even under hypothetical conditions of excellent sanitary infrastructure for a developing country, coverage of collection and treatment of 95% of the generated sewage, and treatment with disinfection at all wastewater treatment plants, concentrations of thermotolerant coliforms in das Velhas River are likely to be above the maximum allowable of 1,000 MPN/100 mL for bathing purposes. The mathematical optimization indicated the need for very high percentages of sewage treatment coverage (near 100%, i.e. universality of collection and treatment) and implementation of disinfection in most treatment plants

  1. Data Integration Acquired from Micro-Uav and Terrestrial Laser Scanner for the 3d Mapping of Jesuit Ruins of SÃO Miguel das MISSÕES

    NASA Astrophysics Data System (ADS)

    Reiss, M. L. L.; da Rocha, R. S.; Ferraz, R. S.; Cruz, V. C.; Morador, L. Q.; Yamawaki, M. K.; Rodrigues, E. L. S.; Cole, J. O.; Mezzomo, W.

    2016-06-01

    The Jesuit Missions the Guaranis were one of the great examples of cultural, social, and scientific of the eighteenth century, which had its decline from successive wars that followed the exchange of territories domain occupied by Portugal and Spain with the Madrid Treaty of January 13, 1750. One of the great examples of this development is materialized in the ruins of 30 churches and villages that remain in a territory that now comprises part of Brazil, Argentina and Paraguay. These Churches, São Miguel das Missões is among the Brazilian ruins, the best preserved. The ruins of São Miguel das Missões were declared a UNESCO World Cultural Heritage in 1983 and the Institute of National Historical Heritage (IPHAN) is the Brazilian Federal agency that manages and maintains this heritage. In order to produce a geographic database to assist the IPHAN in the management of the Ruins of São Miguel das Missões it was proposed a three-dimensional mapping of these ruins never performed in this location before. The proposal is integrated data acquired from multiple sensors: two micro-UAV, an Asctec Falcon 8 (rotary wing) and a Sensefly e-Bee (fixed wing); photos from terrestrial cameras; two terrestrial LIDAR sensors, one Faro Focus 3D S-120 and Optec 3D-HD ILRIS. With this abundance of sensors has been possible to perform comparisons and integration of the acquired data, and produce a 3D reconstruction of the church with high completeness and accuracy (better than 25 mm), as can be seen in the presentation of this work.

  2. [Spanish version of the new World Health Organization Disability Assessment Schedule II (WHO-DAS-II): initial phase of development and pilot study. Cantabria disability work group].

    PubMed

    Vázquez-Barquero, J L; Vázquez Bourgón, E; Herrera Castanedo, S; Saiz, J; Uriarte, M; Morales, F; Gaite, L; Herrán, A; Ustün, T B

    2000-01-01

    The aim of the present paper is to present the initial phases of the development of the Spanish version of the "World Health Organization Disablement Assessment Schedule II" WHO-DAS-II and also to describe the quantitative and qualitative methodological strategies used in the elaboration process of an instrument: i) compatible with the new International Classification of Functioning and Disability -ICIDH-2- of the World Health Organisation; ii) with criteria of cross-cultural applicability and; iii) to allow us to assess the disability in all its dimensions. PMID:10937388

  3. DasPy 1.0 - the Open Source Multivariate Land Data Assimilation Framework in combination with the Community Land Model 4.5

    NASA Astrophysics Data System (ADS)

    Han, X.; Li, X.; He, G.; Kumbhar, P.; Montzka, C.; Kollet, S.; Miyoshi, T.; Rosolem, R.; Zhang, Y.; Vereecken, H.; Franssen, H.-J. H.

    2015-08-01

    Data assimilation has become a popular method to integrate observations from multiple sources with land surface models to improve predictions of the water and energy cycles of the soil-vegetation-atmosphere continuum. Multivariate data assimilation refers to the simultaneous assimilation of observation data from multiple model state variables into a simulation model. In recent years, several land data assimilation systems have been developed in different research agencies. Because of the software availability or adaptability, these systems are not easy to apply for the purpose of multivariate land data assimilation research. We developed an open source multivariate land data assimilation framework (DasPy) which is implemented using the Python script language mixed with the C++ and Fortran programming languages. LETKF (Local Ensemble Transform Kalman Filter) is implemented as the main data assimilation algorithm, and uncertainties in the data assimilation can be introduced by perturbed atmospheric forcing data, and represented by perturbed soil and vegetation parameters and model initial conditions. The Community Land Model (CLM) was integrated as the model operator. The implementation allows also parameter estimation (soil properties and/or leaf area index) on the basis of the joint state and parameter estimation approach. The Community Microwave Emission Modelling platform (CMEM), COsmic-ray Soil Moisture Interaction Code (COSMIC) and the Two-Source Formulation (TSF) were integrated as observation operators for the assimilation of L-band passive microwave, cosmic-ray soil moisture probe and land surface temperature measurements, respectively. DasPy has been evaluated in several assimilation studies of neutron count intensity (soil moisture), L-band brightness temperature and land surface temperature. DasPy is parallelized using the hybrid Message Passing Interface and Open Multi-Processing techniques. All the input and output data flows are organized efficiently

  4. Impact of climate change on snow distribution in Japan estimated using data from the remote weather stations (AMeDAS) and Spot VGT

    NASA Astrophysics Data System (ADS)

    Kominami, Y.; Asaoka, Y.; Tsuyama, I.; Tanaka, N.

    2010-12-01

    Change of the amount of snow by climate change is possibly remarkable in Japan, because air temperature is relatively high as snowy area in the world. And the change of the amount of snow cover highly depends on the supply form of precipitation (rain or snow) in winter corresponding to the change of the temperature in addition to the change of precipitation. And vegetation distribution of Japan is highly affected by snow conditions (snow duration and snow accumulation). To evaluate the change of snow condition in Japan climate change, daily change of SWE of 1km mesh was estimated using daily precipitation and air temperature of AMeDAS(Automated Meteorological Data Acquisition System) data. And using this model, changes of SWE and snow cover period were estimated in condition of global warming. Daily air temperature and precipitation on 1km mesh were estimated over all of Japan by interpolation of the AMeDAS data. AMeDAS is a system that observes the temperature and precipitation, etc. per hour automatically in about 1,300 places (about 17km spacing) in Japan. And daily change of SWE of each point was calculated using degree-day method and threshold temperature for the distinction between snow and rain using these data. We used precipitation and air temperature data of AMeDAS for 23 years from 1980 to 2002. Snow melt coefficient and elevation dependency of winter precipitation of each grid were optimized by snow duration estimated using satellite data (S3 index of Spot VGT) from 1990 to 2000 To estimate the change in the snow accumulation for the years from 2031 to 2051 and from 2081 to 2100, we used the climate change scenario of a high-resolution Regional Climate Model with a 20-km mesh size (RCM20) developed at the Meteorological Research Institute based on the Special Report for Emission Scenario (SRES)-A2. Estimated snow duration was evaluated in 10 points of mountainous snow measurement stations. Averaged error was about 4 days from 1980 to 1999. And estimated

  5. Development of multiplex PCR method for simultaneous detection of four events of genetically modified maize: DAS-59122-7, MIR604, MON863 and MON88017.

    PubMed

    Oguchi, Taichi; Onishi, Mari; Mano, Junichi; Akiyama, Hiroshi; Teshima, Reiko; Futo, Satoshi; Furui, Satoshi; Kitta, Kazumi

    2010-01-01

    A novel multiplex PCR method was developed for simultaneous event-specific detection of four events of GM maize, i.e., DAS-59122-7, MIR604, MON88017, and MON863. The single laboratory examination of analytical performance using simulated DNA mixtures containing GM DNA at various concentrations in non-GM DNA suggested that the limits of detection (LOD) of the multiplex PCR method were 0.16% for MON863, MIR604, and MON88017, and 0.078% for DAS-59122-7. We previously developed a nonaplex (9plex) PCR method for eight events of GM maize, i.e., Bt11, Bt176, GA21, MON810, MON863, NK603, T25, and TC1507. Together with the nonaplex PCR method, the newly developed method enabled the detection and identification of eleven GM maize events that are frequently included in commercial GM seed used in Japan. In addition, this combinational analysis may be useful for the identification of combined event products of GM maize. PMID:20595789

  6. Finanzierung des Studiums

    NASA Astrophysics Data System (ADS)

    Domnick, Ivonne

    "Das liebe Geld“ - ein Thema, das Sie durch das ganze Studium begleitet und auch in der Examensphase und bei der späteren Berufswahl eine entscheidende Rolle spielen wird. Naturwissenschaftler und Ingenieure haben auf dem Arbeitsmarkt sicher derzeit die Nase vorn und brauchen sich über ihre berufliche Zukunft nicht so große Gedanken machen. Doch vor der Karriere muss zunächst einmal eine sichere Studienfinanzierung auf die Beine gestellt werden.

  7. Feeling Normal? Long-Term Follow-up of Patients with a Cleft Lip-Palate after Rhinoplasty with the Derriford Appearance Scale (DAS-59).

    PubMed

    Albers, Andreas E; Reichelt, Andreas C; Nolst-Trenité, Gilbert J; Menger, Dirk Jan

    2016-04-01

    The stigma of nasal deformity due to a congenital cleft lip-palate has an undeniable influence on the affected patient's life. It is therefore of interest to investigate if efforts to reduce esthetic and functional impairments by rhinoplasty (single or multiple) can result in an increased satisfaction with appearance and a self-perception similar to the noncleft population. Retrospective scoring before and after rhinoplasty using the validated Derriford Appearance Scale (DAS-59) and subsequent statistical evaluation and comparison to datasets available in the literature for further classification was used. Of the 61 patients who underwent at least one rhinoplasty, 26 responded to all questions. The mean age of responders was approximately 30 years of age and the male:female ratio was 1:1.2. The scale showed a significant overall improvement after surgery. The full scale and all subscale scores of the DAS-59 were significantly reduced after surgery demonstrating an improvement in the respective categories. Most importantly, if postoperative results were compared with a population concerned and unconcerned about appearance, no difference "facial self-consciousness" of appearance was apparent. Also postoperative subscores for "general self-consciousness" (GSC) and "social self-consciousness" of appearance (SSC) showed no difference from those obtained from the population concerned about appearance. The postoperative subscore for "sexual and bodily self-consciousness" of appearance (SBSC) indicated improvement beyond the level found in the concerned control population. Due to only a low improvement in the difference compared with the subscore representing a "negative self-concept," a statistically significant difference to the concerned population remained, possibly indicating that therapy beyond surgery is needed for improvement. After rhinoplasty, the investigated group of cleft lip-palate patients with nasal deformities showed an improvement in their self

  8. Short-term monitoring of a gas seep field in the Katakolo bay (Western Greece) using Raman spectra DTS and DAS fibre-optic methods

    NASA Astrophysics Data System (ADS)

    Chalari, A.; Mondanos, M.; Finfer, D.; Christodoulou, D.; Kordella, S.; Papatheodorou, G.; Geraga, M.; Ferentinos, G.

    2012-12-01

    A wide submarine seep of thermogenic gas in the Katakolo bay, Western Greece, was monitored passively using the intelligent Distributed Acoustic Sensor (iDAS) and Ultima Raman spectra Distributed Temperature Sensor (DTS), in order to study the thermal and noise signal of the bubble plumes released from the seafloor. Katakolo is one one of the most prolific thermogenic gas seepage zones in Europe and the biggest methane seep ever reported in Greece. Very detailed repetitive offshore gas surveys, including marine remote sensing (sub-bottom profiling, side scan sonar), underwater exploration by a towed instrumented system (MEDUSA), long-term monitoring benthic station (GMM), compositional and isotopic analyses, and flux measurements of gas, showed that: (a) gas seepage takes place over an extended area in the Katakolo harbour and along two main normal faults off the harbour; (b) at least 823 gas bubble ( 10-20 cm in diameter) plumes escaping over an area of 94,200 m2, at depths ranging from 5.5 to 16 m; (c) the gas consists mainly of methane and has H2S levels of hundreds to thousands ppmv, and shows significant amounts of other light hydrocarbons like ethane, propane, iso-butane and C6 alkanes, (d) offshore and onshore seeps release the same type of thermogenic gas; (e) due to the shallow depth, more than 90 % of CH4 released at the seabed enters the atmosphere, and (f) the gas seeps may produce severe geohazards for people, buildings and construction facilities due to the explosive and toxicological properties of methane and hydrogen sulfide, respectively. For the short-term monitoring, the deployment took place on a site located inside the harbour of Katakolo within a thermogenic gas seepage area where active faults are intersected. The iDAS system makes it possible to observe the acoustical signal along the entire length of an unmodified optical cable without introducing any form of point sensors such as Bragg gratings. When the bubble plumes are released by the

  9. Effect of thermal stratification on free convection in a square porous cavity filled with a nanofluid using Tiwari and Das' nanofluid model

    NASA Astrophysics Data System (ADS)

    Sheremet, M. A.; Dinarvand, S.; Pop, I.

    2015-05-01

    Natural convection in a square porous cavity filled with a nanofluid in conditions of thermal stratification has been numerically studied. The mathematical model has been formulated in terms of the dimensionless stream function and temperature using the Darcy-Boussinesq approximation and Tiwari and Das' nanofluid model with new more realistic empirical correlations for the physical properties of the nanofluids. Formulated partial differential equations along with the corresponding boundary conditions have been solved by the finite difference method. Particular efforts have been focused on the effects of the Rayleigh number, thermal stratification parameter, porosity of the porous medium, solid volume fraction parameter of nanoparticles, and the solid matrix of the porous medium (glass balls and aluminum foam) on the local and average Nusselt numbers, streamlines and isotherms. It has been observed an essential effect of thermal stratification parameter on heat and fluid flow fields.

  10. Dating human occupation at Toca do Serrote das Moendas, São Raimundo Nonato, Piauí-Brasil by electron spin resonance and optically stimulated luminescence.

    PubMed

    Kinoshita, Angela; Skinner, Anne R; Guidon, Niede; Ignacio, Elaine; Felice, Gisele Daltrini; Buco, Cristiane de A; Tatumi, Sonia; Yee, Márcio; Figueiredo, Ana Maria Graciano; Baffa, Oswaldo

    2014-12-01

    Excavation of Toca do Serrote das Moendas, in Piauí state, Brazil revealed a great quantity of fossil wild fauna associated with human remains. In particular, fossils of a cervid (Blastocerus dichotomus) were found, an animal frequently pictured in ancient rock wall paintings. In a well-defined stratum, two loose teeth of this species were found in close proximity to human bones. The teeth were independently dated by electron spin resonance (ESR) in two laboratories. The ages obtained for the teeth were 29 ± 3 ka (thousands of years) and 24 ± 1 ka. The concretion layer capping this stratum was dated by optically stimulated luminescence (OSL) of the quartz grains to 21 ± 3 ka. As these values were derived independently in three different laboratories, using different methods and equipment, these results are compelling evidence of early habitation in this area. PMID:25456825

  11. Evaluation of two evidence-based knowledge transfer interventions for physicians. A cluster randomized controlled factorial design trial: the CardioDAS Study.

    PubMed

    Amsallem, Emmanuel; Kasparian, Christelle; Cucherat, Michel; Chabaud, Sylvie; Haugh, Margaret; Boissel, Jean-Pierre; Nony, Patrice

    2007-12-01

    To investigate the potential benefits of two modes of evidence-based knowledge transfer ('active' and 'passive' modes) in terms of improvement of intention of prescription, knowledge, and real prescription in practice, we performed an open randomized controlled trial (CardioDAS) using a factorial design (two tested interventions: 'active' and 'passive' knowledge transfer) and a hierarchical structure (cluster of physicians for each department level). The participants were cardiologists working in French public hospitals. In the 'passive' transfer group, cardiologists received evidence-based knowledge material (available on Internet) every week for a duration of 1 year. In the 'active' transfer group, two knowledge brokers (EA, PN) visited the participating departments (every 2 months for 1 year, 2 h per visit). The primary outcome consisted in the adjusted absolute mean variation of score (difference between post- and pre-study session) of answers to simulated cases assessing the intention to prescribe. Secondary outcomes were the variation of answers to a multiple-choice questionnaire (MCQ) assessing knowledge and of the conformity of real prescriptions to evidence-based reference assessing the behavioral change. Twenty-two French units (departments) of cardiology were randomized (72 participating cardiologists). In the 'active' transfer group, the primary outcome was more improved than that in the control (P = 0.031 at the department level, absolute mean improvement of 5 points/100). The change in knowledge transfer (MCQ) was also significant (P = 0.039 at the department level, absolute mean improvement of 6 points/100). However, no benefit was shown in terms of prescription conformity to evidence. For the 'passive' mode of knowledge transfer and for the three outcomes considered, no improvement was identified. CardioDAS findings confirm that 'active' knowledge transfer has some impact on participants' intent to prescribe and knowledge, but no effect on

  12. Application of a Fibre Optic Distributed Acoustic Sensor (DAS) for Shallow Seismic Investigations of a Fractured Dolostone Aquifer in Guelph, Ontario.

    NASA Astrophysics Data System (ADS)

    Munn, J. D.; Parker, B. L.; Coleman, T. I.; Mondanos, M.; Chalari, A.

    2014-12-01

    Understanding groundwater flow and contaminant transport in fractured bedrock aquifers requires detailed characterization of the discrete features that control flow, as well as the properties of the rock matrix. This requires multiple, high-resolution, depth discrete datasets that provide different, but complementary information. Distributed fibre optic sensing is a relatively new technology used to continuously monitor properties along the entire length of an optical fibre. Technological advances over the past few years have brought the sensitivity and spatial resolution to the point where shallow (<200m) borehole applications are practicable. Recent studies using fibre optic distributed temperature sensors (DTS) have shown excellent application of DTS for characterizing groundwater flow in both continuously sealed and open boreholes. This presentation highlights the results of a field trial at the Bedrock Aquifer Research Station on the University of Guelph campus (Ontario, Canada) where a single fibre optic cable was interrogated by both a DTS (Ultima-DTS) and a Distributed Acoustic Sensor (iDAS). DAS is a relatively recent development that allows an optical fibre to be used as a receiver for seismic imaging. These seismic images are produced by sending an optical pulse down the fibre and analyzing the effects of seismic waves on the propagating light. Numerous vertical seismic profiles were collected and the effects of different fibre optic cable structures and coupling techniques were examined. The seismic profiles will help delineate structural features and lithological contacts away from the borehole wall, and will assist in correlating other geophysical, hydraulic, or geological logs collected in the boreholes across the site. Preliminary results show promise for shallow seismic imaging and continued field trials will allow refinement of the technique.

  13. Simultaneous functions of the installed DAS/DAK formaldehyde-assimilation pathway and the original formaldehyde metabolic pathways enhance the ability of transgenic geranium to purify gaseous formaldehyde polluted environment.

    PubMed

    Zhou, Shengen; Xiao, Sunqin; Xuan, Xiuxia; Sun, Zhen; Li, Kunzhi; Chen, Limei

    2015-04-01

    The overexpression of dihydroxyacetone synthase (DAS) and dihydroxyacetone kinase (DAK) from methylotrophic yeasts in chloroplasts created a photosynthetic formaldehyde (HCHO)-assimilation pathway (DAS/DAK pathway) in transgenic tobacco. Geranium has abilities to absorb and metabolize HCHO. Results of this study showed that the installed DAS/DAK pathway functioning in chloroplasts greatly enhanced the role of the Calvin cycle in transgenic geranium under high concentrations of gaseous HCHO stress. Consequently, the yield of sugars from HCHO-assimilation increased approximately 6-fold in transgenic geranium leaves, and concomitantly, the role of three original HCHO metabolic pathways reduced, leading to a significant decrease in formic acid, citrate and glycine production from HCHO metabolism. Although the role of three metabolic pathways reduced in transgenic plants under high concentrations of gaseous HCHO stress, the installed DAS/DAK pathway could still function together with the original HCHO metabolic pathways. Consequently, the gaseous HCHO-resistance of transgenic plants was significantly improved, and the generation of H2O2 in the transgenic geranium leaves was significantly less than that in the wild type (WT) leaves. Under environmental-polluted gaseous HCHO stress for a long duration, the stomata conductance of transgenic plants remained approximately 2-fold higher than that of the WT, thereby increasing its ability to purify gaseous HCHO polluted environment. PMID:25698666

  14. Further evidence of 777 Ma subduction-related continental arc magmatism in Eastern Dom Feliciano Belt, southern Brazil: The Chácara das Pedras Orthogneiss

    NASA Astrophysics Data System (ADS)

    Koester, E.; Porcher, C. C.; Pimentel, M. M.; Fernandes, L. A. D.; Vignol-Lelarge, M. L.; Oliveira, L. D.; Ramos, R. C.

    2016-07-01

    In this study new SHRIMP U-Pb zircon data for the Chácara das Pedras Gneiss in Porto Alegre, southern Brazil are presented. They represent a small exposure of the crust which was intruded by a large volume of orogenic to anorogenic granitoids at ca. 618-562 m.y. in the Eastern Domain of the Dom Feliciano Belt. The Chácara das Pedras tonalitic orthogneiss has geochemical similarities with subduction-related magmatic rocks of continental arcs. They present high Sr initial ratios (∼0.712), negative ɛNd(t = 777) values (∼-6), TDM varying from 1.8 to 2.0 Ga. The igneous protoliths of these orthogneisses were previously considered to be Paleoproterozoic based on an upper intercept age of discordant zircon analyses. In the present study these orthogneisses were re-sampled and re-analyzed in an attempt to obtain more concordant analytical data. The U-Pb zircon analyses were carried out using the SHRIMP IIe at the Laboratório de Geocronologia de Alta Resolução of the Universidade de São Paulo. The U-Pb concordia age obtained for igneous textural domains of the zircon grains is 777 ± 4 Ma. A few analyses on zircon overgrowths give poorly defined late Cryogenian ages of ca. 650 Ma. Older ages, mostly discordant, were obtained in a few zircon cores, showing an upper intercept age of ca. 1.9 Ga. One sample of the Três Figueiras Granodiorite, which crosscut the orthogneiss in the same outcrop, was also investigated. The zircons of this granodiorite are, however, mostly metamitic, preventing the determination of a reliable age. Some concordant analyses from a few grains define ages ranging in the interval between ca. 603 and 1022 Ma. The youngest (ca. 603 Ma) may represent a maximum age for the granodiorite crystallization. Older ages, with discordance <10%, are of 745, 777, 836 and 1022 Ma. The 777 ± 4 Ma age obtained for the Chácara das Pedras orthogneiss is the first Early Cryogenian magmatic age determined for granitoids in the Porto Alegre region, although

  15. Water Quality-Quantity Evaluation of the Ribeirão das Posses Watershed, Brazil, applying the AgES-W model.

    NASA Astrophysics Data System (ADS)

    Green, T. R.; Cruz, P. P. N. D.; Figueiredo, R. D. O.; Camargo, P. B. D.; Santos, C. P.

    2015-12-01

    Southeastern Brazil is under a period of drought that has impacted the conservation of watersheds and the management of water quality and quantity for agricultural and urban demands. In this context agro-hydrological modeling tools can generate information of water response over time in response to climate and landuse changes. A 12-km2 watershed which has suffered from anthropogenic activities is the Ribeirão das Posses watershed that is located in the extreme south of Minas Gerais State and is a headwater catchment of the Jaguari river, one of the contributing rivers of the Cantareira Reservoir Complex in the state of São Paulo. This watershed had its landscape changed over the last century from native forests to more homogeneous vegetation for pastures and small crops and some forest plantations fragments with eucalyptus. Currently, the Conservative Waters project has planted some small areas with vegetation of native species, especially where there are springs and at the top of the hills, in order to recover degraded areas and improve the hydrogeochemistry in this study basin. In this context, the AgroEcoSystem-Watershed (AgES-W) model is presented to simulate the water movement and storage in agricultural watersheds with different spatial resolutions of land areas or hydrological responses units. The objectives are to evaluate the quality and quantity of water in Ribeirão das Posses Basin using measured data, then simulate these responses in space and time to test the AgES-W model. The period chosen for research was from 2011 to 2015, because the water quality data were collected during this period. The answers that we hope to find out are: How well does the AgES-W model simulate this Brazilian watershed in the tropics? What are the future prospects of the quality and quantity of water in this basin? The results will help to guide hydrological simulations in similar tropical environments in Brazil in this and other agricultural watersheds with AgES-W.

  16. Using a multi-user desktop-based virtual reality system to recreate the São Miguel das Missões ruins.

    PubMed

    dos Santos, Selan R; Fraga, Letícia S

    2002-10-01

    This paper presents a project initiated back in 1999, in which Virtual Reality is applied in order to create a virtual community over the Internet. The desktop-based multi-user virtual reality system recreates a three-dimensional environment based on photogrammetric maps from the São Miguel das Missões church ruins. The ruins correspond to one of the Jesuit Mission (settlement) which was active in the south of Brazil in the 17th and 18th centuries. It has a great importance to the local region in terms of cultural, historic, and tourist aspects. It has also been inscribed in the UNESCO's world heritage list since 1983. This electronic mock-up allows several interactive operations such as community chats, electronic message exchanging, message boards, walking-through, discussion groups, and embedding of other media such as movies, sound, and html pages. The only requirement necessary to access the community is a web browser powered with any Virtual Reality Modeling Language (VRML) plug-in freely available over the Internet. It is expected that such a solution improves the conservation and dissemination of the Brazilian historic patrimony, congregating history, art, and tourist information in one place on the Internet. PMID:12448784

  17. Dating of fossil human teeth and shells from Toca do Enoque site at Serra das Confusões National Park, Brazil.

    PubMed

    Kinoshita, Angela; Sullasi, Henry L; Asfora, Viviane K; Azevedo, Renata L; Guzzo, Pedro; Guidon, Niede; Figueiredo, Ana Maria G; Khoury, Helen; Pessis, Anne-Marie; Baffa, Oswaldo

    2016-06-01

    This work reports the dating of a fossil human tooth and shell found at the archaeological site Toca do Enoque located in Serra das Confusões National Park (Piauí, Brazil). Many prehistoric paintings have been found at this site. An archaeological excavation unearthed three sepulchers with human skeletons and some shells. Two Brazilian laboratories, in Ribeirão Preto (USP) and Recife (UFPE), independently performed Electron Spin Resonance (ESR) measurements to date the tooth and the shell and obtain the equivalent dose received by each sample. The laboratories determined similar ages for the tooth and the shell (~4.8 kyBP). The results agreed with C-14 dating of the shell and other samples (charcoal) collected in the same sepulcher. Therefore, this work provides a valid inter-comparison of results by two independent ESR-dating laboratories and between two dating methods; i.e., C-14 and ESR, showing the validity of ESR dating for this range of ages. PMID:27276381

  18. Change in CD3 positive T-cell expression in psoriatic arthritis synovium correlates with change in DAS28 and magnetic resonance imaging synovitis scores following initiation of biologic therapy - a single centre, open-label study

    PubMed Central

    2011-01-01

    Introduction With the development of increasing numbers of potential therapeutic agents in inflammatory disease comes the need for effective biomarkers to help screen for drug efficacy and optimal dosing regimens early in the clinical trial process. This need has been recognized by the Outcome Measures in Rheumatology Clinical Trials (OMERACT) group, which has established guidelines for biomarker validation. To seek a candidate synovial biomarker of treatment response in psoriatic arthritis (PsA), we determined whether changes in immunohistochemical markers of synovial inflammation correlate with changes in disease activity scores assessing 28 joints (ΔDAS28) or magnetic resonance imaging synovitis scores (ΔMRI) in patients with PsA treated with a biologic agent. Methods Twenty-five consecutive patients with PsA underwent arthroscopic synovial biopsies and MRI scans of an inflamed knee joint at baseline and 12 weeks after starting treatment with either anakinra (first 10 patients) or etanercept (subsequent 15 patients) in two sequential studies of identical design. DAS28 scores were measured at both time points. Immunohistochemical staining for CD3, CD68 and Factor VIII (FVIII) was performed on synovial samples and scored by digital image analysis (DIA). MRI scans performed at baseline and at 12 weeks were scored for synovitis semi-quantitatively. The ΔDAS28 of the European League Against Rheumatism good response definition (>1.2) was chosen to divide patients into responder and non-responder groups. Differences between groups (Mann Whitney U test) and correlations between ΔDAS28 with change in immunohistochemical and MRI synovitis scores (Spearman's rho test) were calculated. Results Paired synovial samples and MRI scans were available for 21 patients (8 anakinra, 13 etanercept) and 23 patients (8 anakinra, 15 etanercept) respectively. Change in CD3 (ΔCD3) and CD68 expression in the synovial sublining layer (ΔCD68sl) was significantly greater in the disease

  19. Guidelines on Management of Human Infection with the Novel Virus Influenza A (H1N1) – A Report from the Hospital das Clínicas of the University of São Paulo

    PubMed Central

    Hajjar, Ludhmila Abrahao; Schout, Denise; Galas, Filomena Regina Barbosa Gomes; Uip, David Everson; Levin, Anna Sara Shafferman; Filho, Helio Hehl Caiaffa; Sakane, Pedro Takanori; Suslik, Carlos Alberto; de Camargo Teixeira, Jose Manoel; Bonfa, Eloisa; Barone, Antonio Alci; de Arruda Martins, Milton; Boulos, Marcos; Auler, Jose Otavio Costa

    2009-01-01

    The pandemic novel influenza A (H1N1) infection was considered widespread in Brazil on July, 2009. Since then, 9.249 cases were confirmed in Brazil, most of them concentrated in São Paulo. The Hospital das Clínicas of the University of São Paulo is a reference center for H1N1 cases in São Paulo. The purpose of this review is to analyze the evidence concerning diagnosis, prevention, and treatment of novel influenza A (H1N1) infection. In addition, we propose guidelines for the management of this pandemic emphasizing Hospital das Clínicas “bundles” for the control of the pandemic novel influenza A (H1N1). PMID:19841710

  20. Observações das explosões cósmicas de raios gama GRB021004 e GRB021211 com o satélite HETE

    NASA Astrophysics Data System (ADS)

    Braga, J.; Ricker, G.; Hurley, K.; Lamb, D.; Grew, G.; et al.

    2003-08-01

    O High Energy Transient Explorer (HETE) é o primeiro satélite inteiramente dedicado ao estudo das explosões cósmicas de raios gama (ECRGs). Lançado em 9 de outubro de 2000, o HETE possui instrumentação capaz de observar as ECRGs desde o UV até raios gama e localizá-las com precisão de ~ 1-10 minutos de arco. As localizações das ECRGs detectadas são disseminadas rapidamente (em alguns segundos) pela Internet através de uma rede de estações de recepção ao longo do equador. A participação brasileira nesse projeto se dá através da montagem e operação de uma estação de recepção em Natal, RN, e da participação na equipe científica da missão. Neste trabalho são apresentados resultados da observação pelo HETE de duas ECRGs: GRB 021004 e GRB 021211. A GRB021004 foi detectada em raios gama pelo HETE em 4 de outubro de 2002 e localizada em raios-X em apenas 48 s, quando a emissão de raios gama ainda estava se processando. A explosão, relativamente brilhante e longa, durou aproximadamente 100 s. Um transiente óptico de magnitude 15 foi detectado no local da explosão nove minutos após o evento, e observações realizadas após 7 horas determinaram um desvio para o vermelho de absorção de 1,6. O GRB021004 foi o burst mais bem observado até o momento e suas observações em vários comprimentos de onda têm sido fundamentais para o aprimoramento dos modelos de ECRGs. O GRB21211, um burst brilhante e rico em raios-X, foi detectado em 11 de dezembro de 2002 e localizado em raios-X em 22 s após o início do evento. A duração do burst foi de 2,3 s em altas energias (85 a 400 keV) e de 8,5 s em baixas energias (2 a 10 keV). Caso essa explosão não tivesse sido rapidamente localizada pelo HETE, ela teria sido classificada como "opticamente escura", já que o transiente óptico decaiu rapidamente de R < 14 a R»19 dentro dos primeiros 20 minutos e já estava mais fraco do que R»23 depois de 24 horas da ocorrência do burst. Ser

  1. Thirteen week feeding study with transgenic maize grain containing event DAS-Ø15Ø7-1 in Sprague-Dawley rats.

    PubMed

    MacKenzie, Susan A; Lamb, Ian; Schmidt, Jean; Deege, Lora; Morrisey, Michael J; Harper, Marc; Layton, Raymond J; Prochaska, Lee M; Sanders, Craig; Locke, Mary; Mattsson, Joel L; Fuentes, Angel; Delaney, Bryan

    2007-04-01

    Maize line 1507, containing event DAS-Ø15Ø7-1 (1507), is a genetically modified (GM) maize plant that expresses the cry1F gene from Bacillus thuringiensis (Bt) sbsp. aizawai and the phosphinothricin-N-acetyltransferase (pat) gene from Streptomyces viridochromogenes throughout the plant including in the grain expression of the Cry1F protein confers in planta resistance to the European corn borer (ECB; Ostrinia nubilalis Hübner: Crambidae) and other lepidopteran pests. Expression of the PAT protein confers tolerance to the herbicidal active ingredient glufosinate-ammonium. The current study evaluated the nutritional performance of rats fed diets containing 1507 maize grain in a subchronic rodent feeding study. The grains in this study, 1507, its near-isogenic control (33P66), and a non-GM commercial hybrid (33J56) contained similar amounts of proximates, amino acids, minerals, anti-nutrients, and secondary metabolites. The subchronic feeding study compared standard toxicology response variables in rats fed diets containing 1507 maize grain with those in rats fed diets containing non-GM maize grains. All diets were prepared according to the specifications of PMI Nutrition International, LLC Certified Rodent LabDiet 5002 (PMI) 5002). Diets were fed ad libitum to Sprague-Dawley rats for approximately 90 days. In-life response variables included indicators of dietary performance and weekly evaluations for clinical signs of toxicity. No toxicologically significant differences were observed in the nutritional performance variables, clinical and neurobehavioral signs, ophthalmology, clinical pathology (hematology, clinical chemistry, coagulation, and urinalysis), organ weights, and gross and microscopic pathology between any pair of treatment groups. These results demonstrate that 1507 maize grain is as safe and as nutritious as non-GM maize grain. PMID:17097206

  2. Using the DAS-ELISA Test to Establish an Effective Distance Between Bait Stations for Control of Linepithema humile (Hymenoptera: Formicidae) in Natural Areas.

    PubMed

    Song, Jinbo; Benson, Eric P; Zungoli, Patricia A; Gerard, Patrick; Scott, Simon W

    2015-08-01

    Linepithema humile (Mayr), the Argentine ant, is an invasive pest that has spread throughout the United States and is a problem in natural and managed habitats in South Carolina. Foraging patterns and the effectiveness of liquid baits for control of this pest have been studied in urban areas. However, similar studies have not been conducted in natural areas such as parks, picnic grounds, or campsites. L. humile populations can be large and widespread, making them a major nuisance pest for visitors to these natural areas. The primary objective of this study was to determine an effective distance between bait stations for control of L. humile in a natural area. A double antibody-sandwich enzyme-linked immunosorbent assay (DAS-ELISA) procedure was used to detect individual ants that consumed rabbit immunoglobin (IgG) protein for marking and tracking. In both lab and field conditions, there was a significant difference in the detection of IgG in ants fed protein marker mixed with sugar water compared with ants only fed sugar water. Additional field studies revealed that an individual ant could retain detectable levels of protein marker for 3 d and that an ant feeding on IgG containing bait could be detected over 15 m from the original bait source. Overall, we found that using liquid ant baits, with a placement of 20 m between stations, was effective in reducing L. humile numbers between April to October, 2012 in a natural park area of Lake Greenwood State Park, SC. PMID:26470341

  3. Das singuläre Modell der über der Oberfläche von Kryodielektrikas lokalisierten Elektronenzustände

    NASA Astrophysics Data System (ADS)

    Dorofeyev, O. F.; Lysov, B. A.; Pavlova, O. S.; Ternov, I. M.

    Wir schlagen ein neues Modell zur Beschreibung der in der Nähe der Oberfläche von Kryodielektrika lokalisierten Elektronenzustände vor. Dabei wird die Nichteindeutigkeit der selbstadjungierten Erweiterung des Hamilton-Operators der elektrostatischen Bildkräfte an der flachen Grenze Dielektrikum-Vakuum benutzt. Im Unterschied zum bekannten Modell von Grimes enthält das von uns vorgeschlagene Modell nur einen einzigen phänomenologischen Parameter, den Vermischungswinkel. Es zeigt sich, daß die entsprechende Wahl des Vermischungswinkels es erlaubt, die spektroskopischen Daten von elektrischen Dipolübergängen zwischen den Einteilchen-Elektronenzuständen, die über der Oberfläche flüssigen 4He und 3He sowie festen Wasserstoffe lokalisiert sind, vollständig zu beschreiben.Translated AbstractA Singular Model of Electronic States, Localized over the Surface of Cryogenized DielectricA new model for the description of localized electronic states near the surface of a cryogenized dielectric is proposed. In this model an ambiguity of the self-adjoined extention of the Hamiltonian for the problem of the motion of an electron in the field of the electrostatic image at flat boundary dielectric-vacuum is used. The proposed model, in contrast with the well known model of Grimes, contains as only phenomenological parameter the mixing angle. It is shown that the proper choise of the mixing angle makes it possible to completely account for the spectroscopic data on electric dipole transitions between singleparticle electronic states localized over the surfaces of 4He, 3He and also solid hydrogen.

  4. Cometas: Das Lendas aos Fatos

    NASA Astrophysics Data System (ADS)

    Voelzke, M. R.

    O descobrimento de cometas, devido ao seu aparecimento espetacular, tem registro nas mais antigas culturas humanas. A primeira referência situa-se no ano de 1095 antes de Cristo [a.C.; HO; HO, 1962]. A quantidade de registros de descobrimentos cometários, principalmente provenientes do território chinês em particular e do oriente em geral, aumentou gradualmente a partir do quarto século depois de Cristo (d.C.). É de origem chinesa a primeira referência ao cometa P/Halley no ano de 240 a.C. [VOELZKE, 1993]. Com o desenvolvimento da astronomia relativamente às técnicas observacionais os descobrimentos bem como as observações cometárias aumentaram sensivelmente a partir do século XVII, sendo que a partir do século XIX um novo incremento ocorreu devido ao emprego da fotografia e a resultante melhora de sensibilidade na observação.

  5. Das sprachliche Register (Speech Registers)

    ERIC Educational Resources Information Center

    Hess-Luttich, Ernest W. B.

    1974-01-01

    The linguistic behavior of a given individual varies; he will on different occasions speak (or write) differently according to what may be roughly described as different social situations: he will use a number of different registers. The application of such registers both in the field of text analysis and in the preparation of teaching materials…

  6. Entwicklung von umwelt- und naturschutzgerechten Verfahren der landwirtschaftlichen Landnutzung für das Biosphärenreservat Schorfheide-Chorin

    NASA Astrophysics Data System (ADS)

    Meyer-Aurich, Andreas

    1999-11-01

    Mit der vorliegenden Arbeit werden exemplarisch Chancen und Grenzen der Integration von Umwelt- und Naturschutz in Verfahren der ackerbaulichen Landnutzung aufgezeigt. Die Umsetzung von Zielen des Umwelt- und Naturschutzes in Verfahren der Landnutzung ist mit verschiedenen Schwierigkeiten verbunden. Diese liegen zum einen in der Konkretisierung der Ziele, um diese umsetzen zu können, zum anderen in vielfach unzulänglichem Wissen über den Zusammenhang zwischen unterschiedlichen Formen der Landnutzung und insbesondere den biotischen Naturschutzzielen. Zunächst wird die Problematik der Zielfestlegung und Konkretisierung erörtert. Das Umweltqualitätszielkonzept von Fürst et al. (1992) stellt einen Versuch dar, Ziele des Umwelt- und Naturschutzes zu konkretisieren. Dieses Konzept haben Heidt et al. (1997) auf einen Landschaftsausschnitt von ca. 6000 ha im Biosphärenreservat Schorfheide-Chorin im Nordosten Brandenburgs angewendet. Eine Auswahl der von Heidt et al. (1997) formulierten Umweltqualitätsziele bildet die Basis dieser Arbeit. Für die ausgewählten Umweltqualitätsziele wurden wesentliche Einflussfaktoren der Landnutzung identifiziert und ein Bewertungssystem entwickelt, mit dem die Auswirkungen von landwirtschaftlichen Anbauverfahren auf diese Umweltqualitätsziele abgebildet werden können. Die praktizierte Landnutzung von 20 Betrieben im Biosphärenreservat Schorfheide-Chorin wurde von 1994 bis 1997 hinsichtlich ihrer Auswirkungen auf die Umweltqualitätsziele analysiert. Die Analyse ergab ein sehr differenziertes Bild, das zum Teil Unterschiede in der Auswirkung auf die Umweltqualitätsziele für den Anbau einzelner Kulturen oder für bestimmte Betriebstypen zeigte. Es zeigte sich aber auch, dass es bei der Gestaltung des Anbaus einzelner Kulturarten große Unterschiede gab, die für Umweltqualitätsziele Bedeutung haben. Neben der Analyse der Landnutzung im Biosphärenreservat Schorfheide-Chorin wurde ein System entwickelt, mit dem die modellhafte

  7. Integument und Anhangsorgane

    NASA Astrophysics Data System (ADS)

    Schliemann, Harald

    Das Integument umhüllt den Wirbeltierkörper lückenlos. In der embryonalen Mundbucht (Stomodaeum) und der Afterbucht (Proctodaeum) grenzt es an die Auskleidung des Darmrohres. Über die generelle Bedeutung einer Haut als Abgrenzung zwischen Körperinnenraum und Außenmedium hinaus hat es bei Schädeltieren ein breites Spektrum von Funktionen. Die wichtigsten sind: Mechanischer Schutz durch Verhornungen und Verknöch erungen; Wundheilung; Schutz vor Wasserverlust; Schutz vor Infektionen durch bakterizide Drüsensekrete und immunkompetente Zellen; Schutz vor kurzwelliger Strahlung durch Pigmente; Schutz vor Überwärmung durch Schweißdrüsensekrete und Schutz vor Wärmeverlust durch Federn und Haare; Ausbildung lokomotorisch wichtiger Strukturen wie Federn, Flug- und Schwimmhäute, Krallen und Hufe; Redukt ion des Strömungswiderstandes durch Dämpfungshaut; Abgabe von Sekreten zur Ernährung (Milch); Ausbildung von Strukturen zu Nahrungserwerb und_-bearbeitung, z. B. Zähne, Barten;

  8. Epidemiology of Human Infection with the Novel Virus Influenza A (H1H1) in the Hospital das Clínicas, São Paulo, Brazil – June–September 2009

    PubMed Central

    Schout, Denise; Hajjar, Ludhmila Abrahao; Galas, Filomena Regina Barbosa Gomes; Uip, David Everson; Levin, Anna Sara Shafferman; Filho, Helio Hehl Caiaffa; Sakane, Pedro Takanori; Suslik, Carlos Alberto; de Camargo Teixeira, Jose Manoel; Bonfa, Eloisa; Barone, Antonio Alci; de Arruda Martins, Milton; Boulos, Marcos; Auler, Jose Otavio Costa

    2009-01-01

    The pandemic novel influenza A (H1N1) infection was considered widespread in Brazil on July 16, 2009. Since then, 46,810 cases of acute respiratory syndrome have been reported in Brazil, most of them concentrated in São Paulo. Through September 16, we have confirmed 9,249 cases of novel influenza A H1N1in Brazil, including 699 deaths. The mortality rate observed in Brazil is 0.47/100,000 inhabitants and varies according to region. In this period, São Paulo registered 3733 cases (40.3% of the total) of novel influenza A (H1N1) infection and 327 deaths, reflecting a mortality rate of 0.79/100,000 inhabitants. The Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HC) is a reference center for H1N1 cases in São Paulo. During the winter of 2009, 472 patients in this hospital were diagnosed with H1N1 infection; of these, 210 were admitted, and 16 died. To control this pandemic and to provide adequate care for these patients, the Hospital das Clínicas implemented “bundles” including prevention strategies, an epidemiologic surveillance service, availability of fast diagnosis, antiviral treatment and training of staff. The purpose of this manuscript is to describe the epidemiologic features of novel human influenza A (H1N1) infection in the Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo during the winter period of the 2009 pandemic. PMID:19841711

  9. Pyritoxidationsprozesse im cretazischen Emschermergel infolge von aeroben Bedingungen durch den Emscherumbau

    NASA Astrophysics Data System (ADS)

    Droste, Björn; Wisotzky, Frank

    2015-09-01

    Due to the restoration of the Emscher river system, large amounts of the Emschermergel, a Cretaceous sediment containing significant amounts of carbonate and pyrite, will be released from its anoxic state. The oxidation of pyrite results in the release of protons, iron and sulfate. In order to evaluate the impact of the reaction products, extensive laboratory investigations were carried out. The methodology can detect pyrite content in the range of magnitude of the Rhenish lignite mining area (average 0.21 wt.% Pyritic-S). The formation of a naturally-occurring weathering horizon could also be detected. Under laboratory conditions, further oxidation of the weathered laboratory samples could be observed. Column experiments show significant release of sulfate at high concentrations. Hydrochemical modelling and acid-base accounting show neutralization of the free protons by the effective carbonate buffer in the sediment.

  10. Zweiwegintegration durch zweisprachige Bildung? Ergebnisse aus der Staatlichen Europa-Schule Berlin

    NASA Astrophysics Data System (ADS)

    Meier, Gabriela

    2012-06-01

    While there is no simple recipe of how to respond to the multitude of languages present in many European schools, this article presents a promising alternative to monolingual education. The focus is on Staatliche Europa-Schule Berlin (SESB), a two-way immersion (TWI) model that unites children whose mother tongue is German with children whose mother tongue is another locally spoken language in one class and teaches them together in two languages. Thus in this model, offered by 17 primary schools and 13 secondary schools in Berlin, pupils learn in two languages from and with each other. Based on a largely quantitative, quasi-experimental study with 603 students, evidence is provided that there are a number of peace-linguistic benefits that can promote two-way social integration, besides fostering personal and societal multilingualism. This suggests that TWI education as practised in Berlin could serve as an educational model for other multilingual parts of Europe.

  11. Kosteneffiziente Honbearbeitung durch intelligente und flexible Verknüpfung von autarken Honzentren

    NASA Astrophysics Data System (ADS)

    Roth, Günther

    Die Planungsabteilungen in der Automobilindustrie werden vor immer größere Herausforderungen gestsellt. Der zur Verfügung stehende Zeitraum zu einer seriensicheren Umsetzung der entwicklungs- und produktionstechnischen Forderungen wird von Projekt zu Projekt kürzer. Aufgrund des hohen Wettbewerbsdrucks und daraus resultierenden erforderlichen Kostenoptimierungen, die schnelleren Timeto-market-und Innovationszyklen und die vermeintlich zur Kundenbindung erforderlichen, kaum mehr überschaubaren Diversifizierungen in den Modellpaletten lassen den Planungshorizont immer kürzer werden. Die zu beschaffenden Fertigungsanlagen sollen aber in den nächsten 8-12 Jahren all die Varianten produzieren können, die heute nur teilweise oder noch gar nicht bekannt sind.

  12. Durch Raum und Zeit reisen - Eine Theorie gibt Antworten auf alte Fragen

    NASA Astrophysics Data System (ADS)

    Sonne, Bernd; Weiß, Reinhard

    2013-07-01

    Im Rahmen der Relativitätstheorie, sei es die spezielle oder auch allgemeine, kommt man zwangsläufig auf die Fragestellung, ob Zeitreisen möglich sind oder nicht. Es gibt darüber sehr viele Veröffentlichungen, da dieses Thema offensichtlich viele Leute beschäftigt: Naturwissenschaftler, Philosophen, Filmautoren. Wir wollen hier nur einige grundlegende Fragestellungen aufgreifen: Kann man in die Zukunft reisen? Gibt es Reisen mit Überlichtgeschwindigkeit? Wie sieht es aus mit Reisen in die Vergangenheit? Wir unterschieden dabei zwischen mathematischen, physikalischen und technischen Lösungen, die Zeitreisen entweder erlauben oder unmöglich machen.

  13. Hydrogeochemische Entwicklung in einem pleistozänen Porengrundwasserleiter beeinflusst durch Leckage

    NASA Astrophysics Data System (ADS)

    Janković, Arabella; Isenbeck-Schröter, Margot

    2012-12-01

    At a former industrial site in north-western Germany, the lower Quaternary aquifer was investigated with respect to hydrogeology and hydrogeochemistry. The upper aquifer was contaminated by chlorinated hydrocarbons (CHCs) from a chemical factory and remediation attempts have been carried out for over 10 years. The hydraulic conditions of both aquifers were characterized with hydraulic head measurements in March 2012. In addition, three sampling campaigns in 2009, 2011 and 2012 helped to describe the geochemistry of the lower aquifer. In the lower aquifer downstream of the remediation area, influence of contamination as well as the remediation measures should also be visible. In order to demonstrate leakage from the upper aquifer and to show the development of the geochemical characteristics, a transport and reaction model was developed using PhreeqeC. These simulations strengthen the assumption of a leakage scenario. This leads to unexpected nitrate concentrations, products of degradation of organic substances and signals of former input of waters with high sodium contents. Ion exchange and degradation of organic substances were identified as the most important processes that improve groundwater quality in the lower aquifer downstream of the remediation area.

  14. Bewertung von Fahrerassistenzsystemen mittels der Vehicle in the Loop-Simulation

    NASA Astrophysics Data System (ADS)

    Bock, Thomas

    Mit der Vehicle in the Loop-Simulation hat Audi eine Test- und Simulationsumgebung für Fahrerassistenzsysteme entwickelt, welche die Vorzüge eines realen Versuchsfahrzeugs mit der Sicherheit und Reproduzierbarkeit von Fahrsimulatoren kombiniert. Virtueller Fremdverkehr, Straßenbegrenzungen oder sonstige simulierte Gegenstände werden durch ein "Optical see through Head Mounted Display“ während der Fahrt realitätsnah und kontaktanalog für den Fahrer eingeblendet. Besonders bei der Erprobung aktiver Fahrerassistenzsysteme eröffnen sich durch das Konzept des virtuellen Fremdverkehrs im realen Versuchsfahrzeug neue Möglichkeiten.

  15. Vernetztes Lernen: Eine Unterrichtseinheit mit Heinrich von Kleists Erzahlung "Das Erdbeben in Chili" und Crista Wolfs Roman "Kein Ort. Nirgends" (Networked Learning: An Instructional Unit with Heinrich von Kleist's Story "The Earthquake in Chile" and Christa Wolf's Novel "No Place, No Where").

    ERIC Educational Resources Information Center

    Eidecker, Martina Elisabeth

    1999-01-01

    Presents an instructional model, using Kleist's story "Das Erdbeben in Chili" and Christa Wolf's novel Kei Ort. Nirgends" as a basis. The model clearly distinguishes itself from quantitative models and mediates solid literary knowledge through an inductive approach. Learning takes place in a multidimensional space that makes possible multiple…

  16. Mapping health assessment questionnaire disability index (HAQ-DI) score, pain visual analog scale (VAS), and disease activity score in 28 joints (DAS28) onto the EuroQol-5D (EQ-5D) utility score with the KORean Observational study Network for Arthritis (KORONA) registry data.

    PubMed

    Kim, Hye-Lin; Kim, Dam; Jang, Eun Jin; Lee, Min-Young; Song, Hyun Jin; Park, Sun-Young; Cho, Soo-Kyung; Sung, Yoon-Kyoung; Choi, Chan-Bum; Won, Soyoung; Bang, So-Young; Cha, Hoon-Suk; Choe, Jung-Yoon; Chung, Won Tae; Hong, Seung-Jae; Jun, Jae-Bum; Kim, Jinseok; Kim, Seong-Kyu; Kim, Tae-Hwan; Kim, Tae-Jong; Koh, Eunmi; Lee, Hwajeong; Lee, Hye-Soon; Lee, Jisoo; Lee, Shin-Seok; Lee, Sung Won; Park, Sung-Hoon; Shim, Seung-Cheol; Yoo, Dae-Hyun; Yoon, Bo Young; Bae, Sang-Cheol; Lee, Eui-Kyung

    2016-04-01

    The aim of this study was to estimate the mapping model for EuroQol-5D (EQ-5D) utility values using the health assessment questionnaire disability index (HAQ-DI), pain visual analog scale (VAS), and disease activity score in 28 joints (DAS28) in a large, nationwide cohort of rheumatoid arthritis (RA) patients in Korea. The KORean Observational study Network for Arthritis (KORONA) registry data on 3557 patients with RA were used. Data were randomly divided into a modeling set (80 % of the data) and a validation set (20 % of the data). The ordinary least squares (OLS), Tobit, and two-part model methods were employed to construct a model to map to the EQ-5D index. Using a combination of HAQ-DI, pain VAS, and DAS28, four model versions were examined. To evaluate the predictive accuracy of the models, the root-mean-square error (RMSE) and mean absolute error (MAE) were calculated using the validation dataset. A model that included HAQ-DI, pain VAS, and DAS28 produced the highest adjusted R (2) as well as the lowest Akaike information criterion, RMSE, and MAE, regardless of the statistical methods used in modeling set. The mapping equation of the OLS method is given as EQ-5D = 0.95-0.21 × HAQ-DI-0.24 × pain VAS/100-0.01 × DAS28 (adjusted R (2) = 57.6 %, RMSE = 0.1654 and MAE = 0.1222). Also in the validation set, the RMSE and MAE were shown to be the smallest. The model with HAQ-DI, pain VAS, and DAS28 showed the best performance, and this mapping model enabled the estimation of an EQ-5D value for RA patients in whom utility values have not been measured. PMID:26849891

  17. Cometa Hyakutake (C/1996 B2): análise do gás e características físicas das partículas de poeira

    NASA Astrophysics Data System (ADS)

    Sanzovo, G. C.; de Almeida, A. A.; Boczko, R.

    2003-08-01

    A completa caracterização e compreensão do núcleo de um cometa novo é de fundamental importância para a elucidação dos processos físicos e químicos atuantes na época da formação do Sistema Solar. O Cometa Hyakutake, conjuntamente com o Cometa Hale-Bopp representam os objetos mais brilhantes que visitaram o Sistema Solar Interno nos últimos 20 anos. Neste Trabalho, nós aplicamos o Método Semi-Empírico das Magnitudes Visuais (MSEMV) à aproximadamente 4000 dados observacionais que correlacionam a magnitude visual absoluta com a distância heliocêntrica para o Cometa Hyakutake nas fases pré- e pós-periélicas. Como produto da aplicação desse método, conseguimos caracterizar dimensionalmente seu núcleo e área ativa efetiva. As taxas de produção dos radicais CN, C2 e C3, obtidos a partir de dados disponíveis na literatura, revelam que, além de muito brilhante, o Hyakutake é um cometa "normal" no sentido de Cochran (1986). Desse modo, deduzimos as taxas de perdas de água (em moléculas/s) a partir da análise de sua magnitude visual aparente, e as convertemos em taxas de perdas de gás (em g/s), despreendido pelo nucleo cometário. Com o auxílio do modelo fotométrico clássico da poeira, realizamos uma análise sistemática e uniforme dessa componente cometária, a partir dos fluxos observacionais no contínuo, para os comprimentos de onda 365,0 e 484,5 nm, assumindo que esses fluxos são o resultado da radiação solar espalhada por grãos de partículas micrométricos presentes na coma. Com isso, pudemos obter as taxas de produção (em g/s), cores (relativas à cor neutra solar), e as dimensões efetivas médias das partículas de poeira, bem como as razões poeira-gás.

  18. Lactic acid microbiota identification in water, raw milk, endogenous starter culture, and fresh Minas artisanal cheese from the Campo das Vertentes region of Brazil during the dry and rainy seasons.

    PubMed

    Castro, R D; Oliveira, L G; Sant'Anna, F M; Luiz, L M P; Sandes, S H C; Silva, C I F; Silva, A M; Nunes, A C; Penna, C F A M; Souza, M R

    2016-08-01

    Minas artisanal cheese, produced in the Campo das Vertentes region of Brazil, is made from raw milk and endogenous starter cultures. Although this cheese is of great historical and socioeconomic importance, little information is available about its microbiological and physical-chemical qualities, or about its beneficial microbiota. This work was aimed at evaluating the qualities of the cheese and the components used for its production, comparing samples collected during the dry and rainy seasons. We also conducted molecular identification and isolated 50 samples of lactic acid bacteria from cheese (n=21), water (n=3), raw milk (n=9), and endogenous starter culture (n=17). The microbiological quality of the cheese, water, raw milk, and endogenous starter culture was lower during the rainy period, given the higher counts of coagulase-positive Staphylococcus and total and thermotolerant coliforms. Enterococcus faecalis was the lactic acid bacteria isolated most frequently (42.86%) in cheese samples, followed by Lactococcus lactis (28.57%) and Lactobacillus plantarum (14.29%). Lactobacillus brevis (5.88%), Enterococcus pseudoavium (5.88%), Enterococcus durans (5.88%), and Aerococcus viridans (5.88%) were isolated from endogenous starter cultures and are described for the first time in the literature. The lactic acid bacteria identified in the analyzed cheeses may inhibit undesirable microbiota and contribute to the safety and flavor of the cheese, but this needs to be evaluated in future research. PMID:27289151

  19. Composition of grain and forage from insect-protected and herbicide-tolerant corn, MON 89034 × TC1507 × MON 88017 × DAS-59122-7 (SmartStax), is equivalent to that of conventional corn (Zea mays L.).

    PubMed

    Lundry, Denise R; Burns, J Austin; Nemeth, Margaret A; Riordan, Susan G

    2013-02-27

    Monsanto Company and Dow AgroSciences LLC have developed the combined-trait corn product MON 89034 × TC1507 × MON 88017 × DAS-59122-7 (SmartStax, a registered trademark of Monsanto Technology LLC). The combination of four biotechnology-derived events into a single corn product (stacking) through conventional breeding provides broad protection against lepidopteran and corn rootworm insect pests as well as tolerance to the glyphosate and glufosinate-ammonium herbicide families. The purpose of the work described here was to assess whether the nutrient, antinutrient, and secondary metabolite levels in grain and forage tissues of the combined-trait product are comparable to those in conventional corn. Compositional analyses were conducted on grain and forage from SmartStax, a near-isogenic conventional corn hybrid (XE6001), and 14 conventional reference hybrids, grown at multiple locations across the United States. No statistically significant differences between SmartStax and conventional corn were observed for the 8 components analyzed in forage and for 46 of the 52 components analyzed in grain. The six significant differences observed in grain components (p < 0.05) were assessed in context of the natural variability for that component. These results demonstrate that the stacked product, SmartStax, produced through conventional breeding of four single-event products containing eight proteins, is compositionally equivalent to conventional corn, as previously demonstrated for the single-event products. PMID:23311749

  20. Historisches Rätsel Liebe, Revolution und Mathematik

    NASA Astrophysics Data System (ADS)

    Loos, Andreas

    2002-07-01

    In Jahr 1800 wies William Herschel bei der Untersuchung des Sonnenlichts erstmals Strahlung außerhalb des sichtbaren Spektrums nach. Sein Sohn Frederick entwickelte ein Gerät zur Vermessung der Sonnenintensität, das Aktinometer. Dieses Gerät wurde in einigen Messkampagnen verwendet, setzte sich aber letztlich nicht durch. Heute ist die Vermessung der Sonneneinstrahlung ein wesentlicher Bereich, der zur Modellierung solarer Energiegewinnungsanlagen erforderlich ist.

  1. Johannes Kepler

    NASA Astrophysics Data System (ADS)

    Bialas, Volker

    Johannes Kepler (1571 - 1630) gilt zurecht als einer der bedeutendsten Mathematiker und Astronomen der frühen Neuzeit, doch wurde das Philosophische in seinem Werk bislang kaum in angemessener Weise gewürdigt. Volker Bialas legt eine fundierte und anregende Einführung in Leben, Werk und Weltanschauung Keplers vor und setzt dabei durch die Akzentuierung des philosophisch-ganzheitlichen Denkens bewußt einen Kontrapunkt zum herkömmlichen Kepler-Bild.

  2. Internationale Schulreformtendenzen und das Problem der Lehrerausbildung

    NASA Astrophysics Data System (ADS)

    Kupisiewicz, Czeslaw

    1982-09-01

    The main theme of this article is that the socio-economic and educational changes which have occurred in industrialized countries in the past 20 to 25 years necessitate a thorough reform of the present system of teacher education. The first group of such changes includes the information explosion, greater occupational mobility, the growing significance and increasing role of the sciences, the development of the mass media, higher educational aspirations, technical development, the acceleration of the psycho-physical development of children and youth, and the injurious effects of the uncontrolled development of the constantly changing civilisation (deterioration of the human environment, diseases caused by the effects of civilisation, etc.). In the face of these changes, teachers must not remain indifferent and teacher education systems have to take them into account. Within the second group of changes influencing the content and methods of teacher education, the most important is the generalisation of education at the pre-school, primary and secondary school levels and also at the university level. As a result, education in many types of school and at ever higher levels has lost the elitist character it still had, not so long ago, and has become a mass activity. This has considerably affected teachers' work and, necessarily, also the work of the teacher education systems. In present-day schools it is necessary to emphasize not only the transmission of knowledge of the `know that' type, as was done in the past, but also problem-solving, independent individual and group work, etc., which will enable children and young people to acquire `know-how' and `know-why'. This must also be reflected in teacher education. In order to adapt the teacher education systems to the requirements of the changing society, a reform of the goals, contents and methods of the system will have to be prepared and implemented as a prerequisite and starting point for a global reform of the entire education system.

  3. Kanban - der Weg ist das Ziel

    NASA Astrophysics Data System (ADS)

    Aull, Florian; Berlak, Joachim; Dickmann, Eva; Dickmann, Philipp; Fischäder, Holm; Gerlach, Joachim; Henneberg, Jens; Kapalla, Klaus; Kress, Oliver; Kuttler, Robert; Schneider, Herfried M.; Schürle, Philipp; Stellpflug, Franz-Josef; Wannenwetsch, Ralph; Wulz, Johannes; Zäh, Michael F.

    Wenn man aktuell Produktionsbereiche in Deutschland und Europa besucht, fallen im Zusammenhang mit modernen Produktionsmethoden immer öfter die Begriffe Kanban (jap. Karte, Signal) und Pull-Produktion, und dies nicht ohne Stolz, da diese mit dem schillernden Vorbild des Toyota Produktionssystems in Zusammenhang stehen. Tatsächlich ist Kanban ein integraler Bestandteil moderner Produktionssysteme. Blickt man aber im Rahmen von Prozessanalysen hinter die Fassaden", d. h. in die tägliche Praxis der Arbeitsprozesse, wird man schnell desillusioniert - die viel gepriesenen klassischen Kanban-Regeln werden im Tagesgeschäft nicht eingehalten.

  4. Physikgeschichte Das Rätsel bleibt

    NASA Astrophysics Data System (ADS)

    Hoffmann, Dieter

    2002-05-01

    Die jüngst erfolgte Veröffentlichung von Dokumenten aus dem Privatarchiv der Familie Bohr [1] über den geheimnisumwitterten Besuch von Werner Heisenberg in Kopenhagen im September 1941 hat in den deutschen Medien große Resonanz gefunden [2]. Tatsächlich verraten uns die jetzt veröffentlichten Dokumente sehr viel mehr über die Zeit ihres Entstehens als über den Besuch selbst.

  5. Das Gluck des Lehrers (The Teacher's Happiness).

    ERIC Educational Resources Information Center

    Higgins, Christopher

    2002-01-01

    Argues that the ethics of teaching concerns the relationship between the teaching and the good life. Uses Bernard Williams' ethics/morality distinction. Connects the question of "why teach?" with the question "how should I live?" Asks why the practice of teaching is worth it in terms of self growth and monetary gains. (CAJ)

  6. Komplexität der Geographie

    NASA Astrophysics Data System (ADS)

    Diekert, Volker; Hertrampf, Ulrich

    Das allgemein als Prototyp eines PSPACE-vollständigen Spiels gesehene Geographiespiel wird bezüglich seiner Komplexität genauer untersucht. Das Interesse der theoretischen Informatik an diesem Spiel wurde sehr durch die Darstellung in dem Lehrbuch von Papadimitriou [Pap94] gefördert. Allerdings bestimmt dieses Lehrbuch nicht die Komplexität des Standardspiels sondern verwendet eine Verallgemeinerung. Die Aussage in dem Lehrbuch bleibt damit etwas unbefriedigend und hinter den Möglichkeiten. Wir zeigen hier, dass die komplexitätstheoretische Charakterisierung schon für die Standardvariante des Spiels gilt.

  7. Importance of land use update during the calibration period and simulation of water balance response to land use change in the upper Rio das Mortes Catchment (Cerrado Biome, Central-Western Brazil)

    NASA Astrophysics Data System (ADS)

    Lamparter, Gabriele; Kovacs, Kristof; Nobrega, Rodolfo; Gerold, Gerhard

    2015-04-01

    Changes in the hydrological balance and following degradation of the water ecosystem services due to large scale land use changes are reported from agricultural frontiers all over the world. Traditionally, hydrological models including vegetation and land use as a part of the hydrological cycle use a fixed distribution of land use for the calibration period. We believe that a meaningful calibration - especially when investigating the effects of land use change on hydrology - demands the inclusion of land use change during the calibration period into the calibration procedure. The SWAT (Soil and Water Assessment Tool) model is a process-based, semi-distributed model calculating the different components of the water balance. The model bases on the definition of hydrological response units (HRUs) which are based on soil, vegetation and slope distribution. It specifically emphasises the role of land use and land management on the water balance. The Central-Western region of Brazil is one of the leading agricultural frontiers, which experienced rapid and radical deforestation and agricultural intensification in the last 40 years (from natural Cerrado savannah to cattle grazing to intensive corn and soya cropland). The land use history of the upper Rio das Mortes catchment (with 17500 km²) is reasonably well documented since the 1970th. At the same time there are almost continuous climate and runoff data available for the period between 1988 and 2011. Therefore, the work presented here shows the model calibration and validation of the SWAT model with the land use update function for three different periods (1988 to 1998, 1998 to 2007 and 2007 to 2011) in comparison with the same calibration periods using a steady state land use distribution. The use of the land use update function allows a clearer identification which changes in the discharge are due to climatic variability and which are due to changes in the vegetation cover. With land use update included into the

  8. Determinação da massa de júpiter a partir das órbitas de seus satélites: um experimento didático

    NASA Astrophysics Data System (ADS)

    Schlickmann, M. S.; Saito, R. K.; Becker, D. A.; Rezende, M. F., Jr.; Cid Fernandes, R.

    2003-08-01

    Este trabalho apresenta o roteiro piloto de uma prática observacional em astronomia, junto com os primeiros resultados obtidos nesta fase de implementacão. O projeto, que será executado em duas etapas, visa introduzir noções de Astronomia a alunos do Ensino Médio e iniciantes nos cursos de Física. O experimento consiste em medir as órbitas dos satélites Galileanos e, a partir da análise dos dados coletados, verificar a validade da Lei das órbitas de Kepler, determinando a massa do planeta Júpiter. Em uma primeira etapa, as observações serão feitas utilizando um telescópio Meade LX200 10" e câmera CCD para obter uma seqüência de imagens do planeta, que possibilitará medir o movimento de seus satélites. A segunda etapa terá início a partir do funcionamento do telescópio em modo robótico, com a possibilidade de observações via internet por instituições de ensino. Para o desenvolvimento deste experimento foram inicialmente coletadas várias imagens de Júpiter obtidas com os instrumentos citados acima. Estas imagens serviram como base para confecção dos roteiros para a experiência no nível médio e superior. Os roteiros serão inicialmente apresentados em uma home-page. Nela também se buscará uma contextualização histórica da experiência bem como o estabelecimento de relações com professores e alunos, propostas metodológicas e a disponibilização dos programas computacionais necessários para a utilização "on-line" pelos usuários. O projeto conta com apoio da Fundação VITAE.

  9. Rotação do jato em DG tau próximo à região de sua formação: análise comparativa das velocidades radiais simuladas e observadas

    NASA Astrophysics Data System (ADS)

    Cerqueira, A. H.; de Gouveia dal Pino, E. M.

    2003-08-01

    Os modelos magneto-centrífugos utilizados para explicar a formação dos jatos Herbig-Haro assumem a presença de um disco de acresção em rotação kepleriana na base de lançamento do jato. Neste cenário, o jato transmite a informação da rotação do disco para regiões distantes da fonte central, além da superfície de Alfvén, na região de colimação inicial do jato. Recentemente, Bacciotti et al. (2002, ApJ, 537, L49) obtiveram pela primeira vez uma evidência observacional de rotação em um jato HH, o jato em DG Tau, em regiões próximas da fonte central, compatível (qualitativa e quantitativamente) com o esperado a partir dos modelos magneto-centrífugos para a produção e colimação inicial de jatos HH. No presente trabalho, apresentamos mapas de velocidade radial, obtidos através de simulações numéricas tri-dimensionais SPH, para um jato com características semelhantes ao jato em DG Tau, objetivando uma comparação com os mapas de velocidade radiais obtidos por Bacciotti et al.. Nossos resultados, embora preliminares, indicam que a inclusão de efeitos como a precessão, evidenciada em DG Tau (Dougados et al. 2000, A&A, 357, L61) devem ser levadas em consideração na análise da presença de rotação não só em DG Tau mas em qualquer sistema, com o uso das velocidades radias observadas. A ausência de um grau elevado de simetria axial (quebrada, por exemplo, pela precessão do eixo do jato; ou pela presença de uma superfície interna de trabalho, ou seja, um bow shock interno), implica também em uma maior complexidade nos mapas, com conseqüências relevantes para suas interpretações.

  10. Auf gute Nachbarschaft!. Verantwortungsübernahme durch Unternehmen für die Stadtteilentwicklung - Haniel und Grillo in Duisburg

    NASA Astrophysics Data System (ADS)

    Kleine-König, Christiane; Hohn, Uta

    2016-03-01

    Companies' community involvement turns out to be spatially relevant and-in many cases-to be focused on the near surroundings of the place of business. Some companies strategically align their involvement in order to systematically address local challenges. The essay at hand addresses the subject of corporate social responsibility from a local development perspective. Using the example of two family-owned enterprises based in Duisburg, Haniel and Grillo, it illustrates how socially committed companies can get involved with their local community by acting as good neighbours. Furthermore, it argues that socially committed companies can function as producers of space concerning matters of urban and local development. The specific local settings as well as the economic conditions of the local community serve as an explanatory background of the companies' involvement. The cases presented in this paper prove the firms' specific knowledge of local development needs and possibilities. This makes them qualified partners for local government actors and civil society actors. Thus, in the future, it is worth addressing corporate local responsibility from a governance point of view both in theory and in practice.

  11. Untergrundstörungen durch organische Lösungsmittel in der Atomabsorptionsspektrometrie mit Graphitöfen

    NASA Astrophysics Data System (ADS)

    Gücer, S.; Massmann, H.

    In atomic absorption spectrometry with graphite furnaces, marked background interferences may occur during the atomization step, when organic solvents are used. Aromatic molecules can sorb to the graphite, partly very firmly, so that they appear in the absorption volume only during the atomizing step, even after preceding interim heating to 800°C. The undissociated molecules show characteristic vibrational spectra in which bands with relative sharp edges can be observed. No rotational structure is recognizable. Reliable background measurements may prove problematic if not entirely impossible in some wavelength regions.

  12. Ein besseres Verständnis des Lurbach-Karstsystems durch ein konzeptionelles Niederschlags-Abfluss-Modell

    NASA Astrophysics Data System (ADS)

    Wagner, Thomas; Mayaud, Cyril; Benischke, Ralf; Birk, Steffen

    2013-12-01

    A parsimonious lumped-parameter rainfall-runoff model was tested to determine if it could be used to appropriately represent a karst hydrological system, the Lurbach system in Austria. Simulated and observed hydrographs of spring discharge were favorably simulated for a time period of seven years in spite of the small number of free parameters. Following this period the four year discharge records were only reproducible using strongly different parameter values. Results suggest during this period overflow to neighboring catchments and the capacity of production or routing store have strongly increased. This relationship is also observed in tracer test and baseflow recession data sets and is attributed to the likely redistributions of sediments. Such dynamic processes are rarely accounted for in rainfall-runoff models, and may cause severe prediction uncertainties. However, in the Lurbach system a parsimonious hydrological model was used successfully to characterize changes in hydrological conditions.

  13. Störungen des Betriebs geothermischer Anlagen durch mikrobielle Stoffwechselprozesse und Erfolg von Gegenmaßnahmen

    NASA Astrophysics Data System (ADS)

    Würdemann, Hilke; Westphal, Anke; Kleyböcker, Anne; Miethling-Graff, Rona; Teitz, Sebastian; Kasina, Monika; Seibt, Andrea; Wolfgramm, Markus; Eichinger, Florian; Lerm, Stephanie

    2016-05-01

    In the context of geothermal systems, biofilms can influence mineral formation and material resistance against corrosion. In three geothermal plants with different salinity and temperature, organisms of the sulfur cycle have contributed to process failures. On the cold side of a heat store, the increased diversity and abundance of sulfate reducing bacteria (SRB) revealed their participation in corrosion processes and their contribution to a decline in injection efficiency. In all plants, a temporary ingress of oxygen or nitrate led to an increased abundance of sulfur oxidizing bacteria (SOB) that might have accelerated corrosion. In addition, the increase in SOB abundance led to filter clogging in a cold store. Based on their role in microbial-induced corrosion (MIC), changes in the abundance of SOB and SRB may indicate the cause of failure. Measures to control microbial growth, mineral deposits and corrosion, such as temporary increases in temperature, acidification, and addition of hydrogen peroxide (H2O2) and nitrate, were evaluated.

  14. Störungen des Betriebs geothermischer Anlagen durch mikrobielle Stoffwechselprozesse und Erfolg von Gegenmaßnahmen

    NASA Astrophysics Data System (ADS)

    Würdemann, Hilke; Westphal, Anke; Kleyböcker, Anne; Miethling-Graff, Rona; Teitz, Sebastian; Kasina, Monika; Seibt, Andrea; Wolfgramm, Markus; Eichinger, Florian; Lerm, Stephanie

    2016-06-01

    In the context of geothermal systems, biofilms can influence mineral formation and material resistance against corrosion. In three geothermal plants with different salinity and temperature, organisms of the sulfur cycle have contributed to process failures. On the cold side of a heat store, the increased diversity and abundance of sulfate reducing bacteria (SRB) revealed their participation in corrosion processes and their contribution to a decline in injection efficiency. In all plants, a temporary ingress of oxygen or nitrate led to an increased abundance of sulfur oxidizing bacteria (SOB) that might have accelerated corrosion. In addition, the increase in SOB abundance led to filter clogging in a cold store. Based on their role in microbial-induced corrosion (MIC), changes in the abundance of SOB and SRB may indicate the cause of failure. Measures to control microbial growth, mineral deposits and corrosion, such as temporary increases in temperature, acidification, and addition of hydrogen peroxide (H2O2) and nitrate, were evaluated.

  15. Nitrogen input into the soil by N{sub 2} fixing plants; Stickstoffeintrag in den boden durch stickstoffixierende pflanzen

    SciTech Connect

    Haunold, E.

    1992-04-01

    Only prokaryontic organisms are able to fix nitrogen. These are about 200 species of bacteria and blue green algae. Of their biochemical efficiency about 500,000 eukaryontic plants (thereof about 340,000 species of flowering plants and more than 100,000 species of fungi) and over 1,000,000 species of animals profit. On a global scale about 200 Mio t/a of nitrogen is being fixed by the prokaryonts. Air nitrogen in legumes varies between 50 and 90% and depends upon the relationship between host and microbe, nutrient status of the soil, water and climatic conditions etc.

  16. Entwicklung neuer Uebungsformen durch die Einbeziehung des Mediums Fernsehen (Development of New Types of Exercises through the Use of Television)

    ERIC Educational Resources Information Center

    Eggers, Dietrich

    1975-01-01

    Discusses the use of television in university-preparatory schools. The exercises are supplementary to "Deutsch 2000" (M. Hueber, Munich), and deal with land and culture. Three short films are presented, for use in free comment. Examples of grammar, vocabulary and dictation exercises are given. (Text is in German.) (IFS/WGA)

  17. Energie aus der Tiefe: Geothermische Stromerzeugung

    NASA Astrophysics Data System (ADS)

    Huenges, Ernst

    2004-11-01

    Die Erde birgt überall genug Wärme für die geothermische Erzeugung elektrischen Stroms, die allerdings Wassertemperaturen von über 150 °C braucht. So warme Gesteinsschichten liegen in Mitteleuropa in mindestens 4 km Tiefe. Ein Kraftwerk muss also beim Betrieb über tiefe Bohrungen Wasser durch das Tiefengestein zirkulieren und dort erhitzen. Von Natur aus ist das Gestein jedoch dafür meist zu wenig porös. Deshalb soll das Einpressen von Fluiden unter hohem Druck die natürlichen Risse im Reservoirgestein künstlich vergrößern. Diese Stimulationstechnik erprobte das GeoForschungsZentrum Potsdam erfolgreich an einer 4309 m tiefen Bohrung im Geothermielabor Groß Schönebeck. Eine zweite Bohrung soll nun eine langfristige Wasserzirkulation im Untergrund erforschen. Funktioniert sie stabil, dann soll eine Demonstrationsanlage Strom erzeugen.

  18. SARCOPTERYGII, Fleischflosser

    NASA Astrophysics Data System (ADS)

    Schultze, Hans-Peter

    Unter den rezenten und fossilen Fischen sind die Sarcopterygier durch fleischige Loben an den paarigen Flossen charakterisiert. Fossil gehen sie bis in das Obere Silur (vor 420 Mio. Jahren) zurück. Einige Gruppen (†Onychodontida, †Porolepiformes, †Elpistostegalia) waren auf das Devon beschränkt, andere verschwanden gegen Ende des Paläozoikums (†Rhizodontida, †Osteolepiformes). Nur wenige Arten der Dipnoi (Lungenfische) und Actinistia (Hohlstachler) haben überlebt; aus einer ausgestorbenen Teilgruppe evolvierten die erfolgreichen Tetrapoda. Im Devon waren die Sarcopterygier weltweit verbreitet; ihre rezenten fischartigen Formen sind dagegen auf die Südkontinente bzw. den Indischen Ozean beschränkt. Ursprünglich waren alle Formen marin. Mehrmals unabhängig wurde von ihnen das Süßwasser und innerhalb der Tetrapoden vor allem das Land erobert.

  19. Die Deutsche Statistische Gesellschaft in der Weimarer Republik und während der Nazidiktatur

    NASA Astrophysics Data System (ADS)

    Wilke, Jürgen

    Nach anfänglichen Schwierigkeiten durch den 1. Weltkrieg erlangte die Deutsche Statistische Gesellschaft (DStatG) unter dem renommierten Statistiker und Vorsitzenden der DStatG, Friedrich Zahn, durch eine Vielzahl von Aktivitäten hohes Ansehen. Es gab Bestrebungen, Statistiker aus allen Arbeitsfeldern der Statistik in die DStatG zu integrieren, wobei die "Mathematische Statistik" nur zögerlich akzeptiert wurde (Konjunkturforschung, Zeitreihenanalyse). Nach der Machtübernahme 1933 durch Adolf Hitler geriet die DStatG in das Fahrwasser nationalsozialistischer Ideologie und Politik (Führerprinzip, Gleichschaltung des Vereinswesens). Damit war eine personelle Umstrukturierung in der DStatG verbunden. Politisch Missliebige und rassisch Verfolgte mussten die DStatG verlassen (Bernstein, Freudenberg, Gumbel u.a.). Unter den Statistikern gab es alle Abstufungen im Verhalten zum Regime von Ablehnung und zwangsweiser Anpassung über bereitwilliges Mitläufertum bis zu bewusster Täterschaft. Besonders die Bevölkerungsstatistik wurde durch die NS- Rassenpolitik auf lange Sicht diskreditiert. Im Rahmen von Wirtschaftsplanung und Aufrüstung wurden neue zukunftsträchtige statistische Modelle (Grünig, Bramstedt, Leisse) entwickelt.

  20. Ein Entscheidungsmodell zur Weitergabe persönlicher Daten im Internet

    NASA Astrophysics Data System (ADS)

    Treiblmaier, Horst

    In den vergangenen zwei Jahrzehnten wandelte sich das Internet von einer Spielwiese für technikbegeisterte Computerspezialisten zu einem vielseitig einsetzbaren weltweiten Netzwerk für Privatpersonen und Unternehmen. Maßgeblichen Anteil daran besaß die rasante Entwicklung des World Wide Web (WWW), das, durch die Möglichkeit multimediale Inhalte zu vermitteln, für einen großen Teil der Bevölkerung industrialisierter Länder zu einem wesentlichen Bestandteil des täglichen Lebens wurde. Dass diese Entwicklung noch lange nicht abgeschlossen ist, zeigt die derzeitige Diskussion zum Thema Web 2.0 bzw. 3.0. Waren es in den letzten Jahren die hohen Umsatzzuwächse im E-Commerce und multimedial gestaltete Webseiten in Kombination mit aufwändigen Applikationen, die für ständig steigende Nutzerzahlen im World Wide Web sorgten, so wird dieser Innovationsschub nunmehr durch eine Vielzahl von Anwendungen fortgesetzt, die sich durch die zunehmende Vernetzung der Nutzer untereinander auszeichnen.

  1. Analytik von Lebensmittelallergenen

    NASA Astrophysics Data System (ADS)

    Demmel, Anja; Hahn, Alexandra

    Ansonsten harmlose Lebensmittel oder deren Bestandteile können bei von Lebensmittelallergien betroffenen Personen Überempfindlichkeitsreaktionen auslösen. Hierbei kann es sich um immunvermittelte Lebensmittelallergien oder um Intoleranzen gegenüber bestimmten Lebensmittelbestandteilen handeln. Ein Beispiel für Letzteres ist die Laktoseintoleranz, welche durch einen Enzymdefekt hervorgerufen wird [1]. Im Gegensatz hierzu handelt es sich bei Lebensmittelallergien um Sofortreaktionen, die durch IgE-Antikörper gegen Antigene aus den Lebensmitteln hervorgerufen werden und zu verschiedenen körperlichen Beschwerden führen können. Bei den Antigenen, welche von den von Allergikern produzierten IgE-Antikörpern erkannt werden, handelt es sich vor allem um Proteine [2]. Symptome IgE-vermittelter Reaktionen können zum Beispiel Hautausschlag, eine Schwellung der Schleimhäute oder das sogenannte orale Allergiesyndrom mit allergischen Reaktionen an der Mundschleimhaut und im Magen-Darm-Trakt sein [3]. Die hierbei auftretenden Beschwerden reichen von einem Brennen im Mund und einer Schwellung der Lippen und der Zunge bis zu Atemnot verursachenden Schwellungen im Kehlkopfbereich. In besonders schlimmen Fällen können allergische Reaktionen zu einem anaphylaktischen Schock und zum Tod durch Kreislaufversagen führen [4]. Während klassische Nahrungsallergene häufig komplexe Reaktionen zur Folge haben, ist bei Pollen-assoziierten Nahrungsmittelallergien das orale Allergiesyndrom vorherrschend.

  2. Molekulare Methoden zum Nachweis, zur Quantifizierung und zum Monitoring der Mykotoxinbildung lebensmittelrelevanter Pilze

    NASA Astrophysics Data System (ADS)

    Geisen, Rolf

    Schimmelpilze kommen ubiquitär vor und spielen besonders bei pflanzlichen Lebensmitteln und Rohprodukten eine besondere Rolle als Verderbsorganismen. Es wird geschätzt, dass 20-25 % der jährlichen Produktion an pflanzlichen Produkten durch Schimmelpilze verdorben werden (Smith et al., 1994). Viele der lebensmittelrelevanten Schimmelpilze sind zudem in der Lage, Mykotoxine, toxische Sekundärmetabolite, zu bilden, was das Ausmaß des Problems deutlich macht. Die wichtigsten mykotoxinbildenden Spezies gehören zu den Fusarien (Trichothecene, Fumonisine, Zearalenon), Aspergillen (Aflatoxin, Ochratoxin, Cyclopiazonsäure) und Penicillien (Patulin, Ochratoxin). Für viele Mykotoxine, wie die Aflatoxine, Ochratoxin, Fumonisine und Trichothecene sind Grenzwerte erlassen worden, die die Verkehrsfähigkeit betroffener Produkte regeln. Die Einhaltung der Grenzwerte kann sehr genau durch offizielle chemisch-analytische Methoden, wie HPLC, GC-MS etc. kontrolliert werden. Diese analytischen Methoden sind aber für die Anwendung eines HACCP-Ansatzes zur Kontrolle der Mykotoxinbildung nur bedingt geeignet, da sie Endpunktkontrollen darstellen und nur das über eine längere Zeit gebildete Mykotoxin bestimmen. Sie sagen daher nichts über die biologischen Bedingungen zur Zeit der Bildung durch den Pilz aus.

  3. Von der Prägeometrie zur Topologischen Komplexität.

    NASA Astrophysics Data System (ADS)

    Kurth, D.

    Der Autor macht in seinem Beitrag gegen das vorherrschende reduktionistische Selbstverständnis der modernen Physik geltend, daß eine umfassende Theorie von Allem (TOE) nicht schon durch eine Alles vereinheitlichende Theorie als Abschluß des reduktionistischen Programms der Elementarteilchenphysik gegeben sein kann. Zum einen muß der initialen Kontingenz unseres Universums durch eine entsprechende quantenkosmologische Theorie Rechnung getragen werden, zum anderen muß auch die in dieser Kontingenz begründete Geschichtlichkeit unseres Universums, d.h. die Emergenz von Komplexität, von einer angemessenen TOE erklärt werden können. Der Autor zeigt, daß ein solcher Anspruch nicht mit den üblichen Komplexitätsmaßen der heutigen Komplexitätstheorien eingelöst werden kann, und schlägt als Alternative einen unmittelbar emergenztheoretisch begründeten Komplexitätsbegriff, den der Topologischen Komplexität vor.

  4. Klassifikation von Standardebenen in der 2D-Echokardiographie mittels 2D-3D-Bildregistrierung

    NASA Astrophysics Data System (ADS)

    Bergmeir, Christoph; Subramanian, Navneeth

    Zum Zweck der Entwicklung eines Systems, das einen unerfahrenen Anwender von Ultraschall (US) zur Aufnahme relevanter anatomischer Strukturen leitet, untersuchen wir die Machbarkeit von 2D-US zu 3D-CT Registrierung. Wir verwenden US-Aufnahmen von Standardebenen des Herzens, welche zu einem 3D-CT-Modell registriert werden. Unser Algorithmus unterzieht sowohl die US-Bilder als auch den CT-Datensatz Vorverarbeitungsschritten, welche die Daten durch Segmentierung auf wesentliche Informationen in Form von Labein für Muskel und Blut reduzieren. Anschließend werden diese Label zur Registrierung mittels der Match-Cardinality-Metrik genutzt. Durch mehrmaliges Registrieren mit verschiedenen Initialisierungen ermitteln wir die im US-Bild sichtbare Standardebene. Wir evaluierten die Methode auf sieben US-Bildern von Standardebenen. Fünf davon wurden korrekt zugeordnet.

  5. Die Struktur von schlankem Materialfluss mit Lean Production Kanban und Innovationen

    NASA Astrophysics Data System (ADS)

    Scheid, Wolf-Michael

    In der Literatur wird Materialfluss überwiegend in Spezialdisziplinen betrachtet, etwa der Steuerungslogik, der Logistiktechnik oder dem Supply Chain Management. Ein charakterisierendes Merkmal des Materialflusses ist jedoch, dass er sich aus vielfältigen Einzelbausteinen zusammensetzt, die alle harmonisch abgestimmt sein müssen. Die maximal erreichbare Effizienz wird nicht durch Höchstleistungen in dem einen oder anderen Spezialthema bestimmt, sondern durch das schwächste Glied im gesamten komplexen Netzwerk. Den Schnittstellen zwischen den betroffenen Fachbereichen in einem Unternehmen kommt hier eine ganz besondere Bedeutung zu: Erst ein harmonischer Einklang ermöglicht hohe Effektivität. Dies setzt umfassendes Verständnis für interdisziplinäre Notwendigkeiten, ein hohes Maß an Abstimmung mit den operativen Prozessen und letztlich einen einvernehmlichen Umgang und den Respekt vor den Problemstellungen des Anderen voraus.

  6. Molekulare Nanomaschinen unter der Lupe: Proteindynamik-Simulationen

    NASA Astrophysics Data System (ADS)

    de Groot, Bert L.; Böckmann, Rainer A.; Grubmüller, Helmut

    2006-01-01

    Moderne computergestützte Simulationsverfahren erlauben tiefe Einblicke in biologische Funktionsprozesse. Sie zeigen in atomarer Auflösung, wie Proteine als biologische Nanomaschinen funktionieren. Entscheidend ist dabei deren dynamisches Verhalten. Die Strukturaufklärung liefert meist nur statische Bilder der eingefrorenen räumlichen Gestalt der Proteine. Molekulardynamik-Simulationen machen dagegen Bewegungen sichtbar. Sie konnten zum Beispiel offen legen, wie das Protein F-ATP-Synthase das Adenosintriphosphat (ATP) synthetisiert, den zentralen Energieträger des Körpers. Die F-ATP-Synthase arbeitet dabei wie ein mechano-chemischer Dreizylindermotor. Sie ist die kleinste bekannte Nanomaschine der Welt. Ein anderes Beispiel ist die Simulation des komplexen Mechanismus, mit dem das Protein Aquaporin Wassermoleküle durch Zellmembranen schleust.

  7. IQM-Reifegradmodell für die Bewertung und Verbesserung des Information Lifecycle Management Prozesses

    NASA Astrophysics Data System (ADS)

    Baškarada, Saša; Gebauer, Marcus; Koronios, Andy; Gao, Jing

    Heutige Organisationen produzieren und speichern mehr Informationen als je zuvor. Der resultierende Informationsüberfluss, zusammen mit einem Mangel an Qualitätssicherung für das Information Lifecycle Management, führt zu einem unsicheren Status der Informationsqualität in vielen Organisationen. Weiterhin hat sich herausgestellt, dass das Bewerten, Verbessern und Steuern der Informationsqualität ein offenkundig schwieriges Unterfangen ist. Dieses Kapitel stellt ein Modell zur Bewertung und Verbesserung der Information Quality Management Capability Maturity (IQM-Reifegrad) vor. Es wird ein Satz von Kriterien vorgestellt, der aus Literaturrecherche und Fallstudien abgeleitet wurde. Die Reifegradindikatoren werden validiert und in einem mehrstufigen Reifegradmodell durch eine Delphi-Studie gruppiert. Das abgeleitete IQM-Reifegradmodell hilft Organisationen ihre bestehenden Praktiken im IQM zu bewerten und potentielle Lücken und Verbesserungsstrategien zu ermitteln.

  8. Implementierungstechniken

    NASA Astrophysics Data System (ADS)

    Lippe, Wolfram-Manfred

    Die klassische Technik zur Implementierung funktionaler und applikativer Sprachen ist die des Interpretierens. Stammvater aller Interpretierer ist der in Kapitel 3.2.2.12 vorgestellte Interpretierer von McCarthy. Das Hauptproblem aller Implementierungstechniken, die Bindung von Werten an Namen, wird bei ihm durch das Konzept der Assoziationsliste (A-Liste) realisiert. Die Elemente dieser Liste sind Paare, deren 1. Komponente aus einem Namen und deren 2. Komponenete aus einem Wert besteht. Anschaulich kann man sich die A-Liste als einen Keller vorstellen, in den bei jeder Bindung eines Wertes an einen Namen, z.B. bei einer Funktions-Deklaration (Label-Deklaration) oder einer Funktionsapplikation, das entsprechende Paar gespeichert wird.

  9. Radioaktive Biomaterialien

    NASA Astrophysics Data System (ADS)

    Assmann, Walter

    In der Strahlentherapie von Tumorgewebe (Radioonkologie) nutzt man die zellschädigende Wirkung verschiedener Strahlenarten zur gezielten Abtötung der Tumorzellen. Um bei der perkutanen Bestrahlung die Strahlenschäden im gesunden Gewebe in Grenzen zu halten, wird der Tumor aus verschiedenen Richtungen mit gut fokussiertem Strahl behandelt. Moderne Bestrahlungsanlagen sind durch Steuerung über leistungsfähige Rechner in der Lage, ein millimetergenaues Bestrahlungsprogramm abzufahren, das individuell auf den jeweiligen Tumor abgestimmt ist. Ein ganz anderer Weg, das umgebende gesunde Gewebe zu schonen, wird in der sog. Brachytherapie beschritten. Hier wird ein kurzreichweitiger, radioaktiver Strahler entweder direkt in das Tumorgewebe (interstitiell) oder in grosser Nähe (intrakavitär) permanent oder nur für eine bestimmte Zeitdauer eingebracht. Ein Beispiel ist die Behandlung des Prostatakarzinoms durch die Implantation von dünnwandigen metallischen Hülsen (seeds) von nur wenigen Millimetern Länge und knapp einem Millimeter Durchmesser, die minimalinvasiv mittels feiner Kanülen in die Prostata eingebracht werden. Sie enthalten ein künstliches Radionuklid mit typisch einigen Wochen Halbwertszeit, dessen therapeutisch wirksame Strahlungsdosis sich auf wenige Millimeter des umgebenden Gewebes beschränkt. Wesentlich für den Erfolg einer Strahlentherapie mit derartig kurzreichweitigen Strahlern ist eine Lagekontrolle mit entsprechend hoher räumlicher Auflösung.

  10. Blutpräparate und therapeutische Anwendung (Hämotherapie)

    NASA Astrophysics Data System (ADS)

    Burkhart, Jürgen; Leimbach, Rainer; Nagl, Detlev; Weinauer, Franz

    Die Geschichte der Blutübertragung lässt sich bis in das Altertum verfolgen - wenn auch hier das Blut nicht in die Blutgefäße eingebracht, sondern als Trank verabreicht wurde. Im alten Rom stürmten die Zuschauer in die Kampfarena, um das Blut verletzter Gladiatoren zu trinken, in dem Gedanken, deren Stärke würde in sie überfließen. So wurden auch Greise mit dem Blut von Jünglingen behandelt. Der Glaube, mit dem Blut würden Eigenschaften des Spenders übertragen, muss wohl auch bei dem Versuch mitgewirkt haben, Verbrecher durch Übertragung von Schafsblut "lammfromm“ zu machen. Zu Beginn der Mensch-zu-Mensch-Übertragung wurde Blut mittels eines Röhrchens von Blutgefäß zu Blutgefäß transfundiert. Diese im Mittelalter neu erprobte Form basierte auf der Entdeckung des Blutkreislaufes durch William Harvey (1578-1657). Es überwog allerdings noch die Blutübertragung vom Tier auf den Menschen, die nicht selten mit dem Tod beider Beteiligter endete. In der aufklärerischen Phase der französischen Revolution wurde diese Art der Blutübertragung deshalb verboten.

  11. Therapeutisches Management kutaner und genitaler Warzen.

    PubMed

    Ockenfels, Hans Michael

    2016-09-01

    Mindestens 10 % der Bevölkerung erkranken während ihres Lebens an einer Infektion mit humanen Papillomaviren (HPV), welche sich klinisch anhand der Ausbildung kutaner oder genitaler Warzen manifestiert. Obwohl Warzen ubiquitär sind, existieren keine definierten Behandlungen. Warzen zeigen, insbesondere in den ersten sechs Monaten, eine erhöhte Selbstheilungsrate. Dieser Umstand erschwert die Interpretation von Studien, da häufig Patienten mit Neuinfektionen zusammen mit Patienten mit Altinfektionen behandelt werden. Lokalisationen, Größe und Dicke der Warzen sind ebenfalls in den meisten Fällen nicht berücksichtigt. Ziel dieses Übersichtsartikels ist eine Analyse des vorliegenden Studienmaterials, unter der für den klinischen Alltag so wichtigen Berücksichtigung von Subtypen und Lokalisationen. Insbesondere die Abgrenzung zwischen frischen und chronisch-therapieresistenten Verrucae vulgares spiegelt sich in einem Therapiealgorithmus wider. Bei genitalen Warzen wird der Therapiealgorithmus deutlicher durch das Ausmaß der infizierten Fläche als durch das Alter der Warzen bestimmt. Bei immunkompetenten Personen muss es mit den hier aufgezeigten therapeutischen Methoden immer das Ziel sein, eine komplette Abheilung zu erzielen. PMID:27607029

  12. Proving the Orbits of the Galilean Moons Through Astrophotography. (Spanish Title: Comprobando Las Órbitas de Las Lunas Galileanas a Través de la Astrofotografía.) Evidenciando as Órbitas das Luas Galileanas Atravéd da Astrofotografia

    NASA Astrophysics Data System (ADS)

    Iachel, Gustavo

    2009-12-01

    An activity related to the observation of the Galilean moons and to amateur astrophotography is presented in this work. Through the reading of excerpts of the book Sidereus Nuncius (Sidereal Messenger), by Galileo, it is possible to trace a methodology to observe the planet and its natural satellites and, with the aid of the astrophotography, to analyze the field recordings. Moreover, it is possible to compare the images obtained after plotting the relative positions of these moons to prove their orbits. This activity can be conducted by teachers, students and amateur astronomers, in order to develop their capabilities of observation of astronomical phenomena. Se presenta en este trabajo una actividad relacionada a la observación de las lunas Galileanas y a la astrofotografía amateur. A través de la lectura de tramos de la obra Sidereus Nuncius (El Mensajero Sideral) de Galileo, es posible trazar una metodología para la observación del planeta y de sus satélites naturales y, con el auxilio de la astrofotografía, analizar las anotaciones de campo. Además, es posible comparar las imágenes obtenidas con el gráfico de las posiciones relativas de estas lunas para comprobar sus órbitas. Esa actividad puede ser realizada por maestros, estudiantes y astrónomos amateurs, de forma a desarrollar sus capacidades de observación de los fenómenos astronómicos. Uma atividade relacionada à observação das luas Galileanas e à astrofotografia amadora é apresentada neste trabalho. Através da leitura de trechos da obra Sidereus Nuncius (Mensageiro Sideral), de Galileu, é possível traçar uma metodologia para a observação do planeta e de seus satélites naturais e, com o auxílio da astrofotografia, analisar as anotações de campo. Além disso, é possível comparar as imagens obtidas com o gráfico das posições relativas destas luas para evidenciar suas órbitas. Essa atividade pode ser realizada por professores, estudantes e astrônomos amadores, de forma a

  13. Entwicklung und Evaluation einer Kalibrierungsmethode für 3D-Ultraschall

    NASA Astrophysics Data System (ADS)

    Bergmeir, Christoph; Seitel, Mathias; Frank, Christian; de Simone, Raffaele; Meinzer, Hans-Peter; Wolf, Ivo

    Wir stellen eine Methode zur Kalibrierung einer 3D-Ultraschallsonde vor. Für Anwendungen in der minimalinvasiven Chirurgie wird die Ultraschallsonde mit einem Trackingsystem verbunden, um dem Aufnahmevolumen eine definierte räumliche Lage zu geben. Die Kalibrierung bringt die Koordinatensysteme des Trackingsystems und des Ultraschallbildes zur Deckung. Hierzu wird ein bekanntes Objekt, das Phantom, aufgenommen und im Ultraschallbild lokalisiert. Die Kalibrierungstransformation wird dann durch ein Verfahren der Hand-Auge-Kalibrierung errechnet. Ein oft übliches Anbringen zusätzlicher Trackingssensoren am Phantom ist damit nicht nötig, was die Kalibrierungsprozedur vereinfacht.

  14. Erfahrungen im Aufbau des IT Service Desks der Technischen Universität München

    NASA Astrophysics Data System (ADS)

    Vellguth, Karmela

    Durch das Projekt IntegraTUM und die darin eingebettete Einrichtung eines IT Service Desks mit 1st, 2nd und 3rd Level Support gelang eine an ITIL orientierte Neuausrichtung der internen IT-Dienstleistungen. Die vormals existierende Struktur mit einer Vielzahl an Ansprechpartnern bei auftretenden IT-Problemen wurde aufgelöst. Die Nutzer haben nun eine Anlaufstelle erhalten, die sich für die Beantwortung aller Incidents in kürzester Zeit und mit qualitativ hohem Niveau zuständig fühlt.

  15. Sandsturm kontra Wassersturm: Physik im Alltag

    NASA Astrophysics Data System (ADS)

    Müller, Andreas

    2006-07-01

    Sandstürme ereignen sich oft, Wasserstürme hingegen so gut wie nie. Eine Abschätzung zeigt, dass man beim Herauslösen eines Wassertropfens beispielsweise aus dem Meer eine sehr große Kraft benötigt und sehr viel Arbeit verrichten muss. Das scheint die Erklärung zu sein. Führt man eine entsprechende Energiebetrachtung durch, so könnte es durchaus Wasserstürme geben. Diese Überlegung ist zwar mathematisch richtig, aber unvollständig.

  16. Vom magnetischen Bakterium zur Brieftaube: Geo-Biomagnetismus

    NASA Astrophysics Data System (ADS)

    Winklhofer, Michael

    2004-05-01

    Die Fähigkeit, das Erdmagnetfeld wahrzunehmen und sich an ihm zu orientieren, ist im Tierreich weit verbreitet. Durch welche physikalischen Mechanismen magnetische Sinnesreize in Nervensignale umgesetzt werden, ist jedoch weitgehend ungeklärt. Bei magnetotaktischen Bakterien üben zum Beispiel biogene ferrimagnetische Kristalle als mikroskopische Kompassnadeln ein Drehmoment auf die Zelle aus. Magnetit findet sich im Gewebe zahlreicher Tiere. Doch erst bei zwei Arten, der Brieftaube und der Regenbogenforelle, konnten auch entsprechende Sinneszellen gefunden werden. Diese unterscheiden sich allerdings in ihren magnetischen Eigenschaften fundamental voneinander. Die Identifizierung der physikalischen Mechanismen des Geo-Biomagnetismus bleibt eine Herausforderung für Biophysik und Sinnesphysiologie.

  17. Einleitung

    NASA Astrophysics Data System (ADS)

    Winner, Hermann; Hakuli, Stephan; Wolf, Gabriele

    Das Thema Fahrerassistenzsysteme ist bei Automobilherstellern, Zulieferern und in der universitären Forschung seit geraumer Zeit aktuell und hat in den vergangenen Jahren auch das Interesse der Öffentlichkeit geweckt. Die Zahl der am Markt verfügbaren Systeme und ihr Funktionsumfang zur Unterstützung des Fahrers bei der Ausführung der Fahraufgabe nehmen stetig zu. Bedingt durch die jüngsten Entwicklungen wird der Begriff Fahrerassistenzsysteme (in unserer abgekürzten Welt kurz mit FAS bezeichnet) heute zumeist mit Systemen der Aktiven Sicherheit, d. h. Systemen, die das Eintreten eines Unfalls verhindern, in Verbindung gebracht. Tatsächlich kann dieser Begriff jedoch sehr viel breiter gefasst werden, denn schon mit der Erfindung des elektrischen Starters, der die manuelle Kurbel ablöste, war ein erstes Fahrerassistenzsystem geboren, das das Fahren erleichterte. Auch Dinge wie die automatische Blinkerhebelrückstellung oder das synchronisierte Handschaltgetriebe werden heute als Selbstverständlichkeiten angesehen, sind im eigentlichen Sinne jedoch als Fahrerassistenzsysteme zu verstehen.

  18. Remark on Groups and Internal Structure in Continuum Mechanics

    NASA Astrophysics Data System (ADS)

    Günther, H.

    Any mechanical motion within a solid is subjected to the group of external motion (Galilean group or if necessary for relativistic mechanics the Lorentz group) and to the internal quasi Lorentz group lq being independent of the external one. Since the effect of the external group always may be simulated by a system of external forces, any internal property is subjected to lq (e.g. quasi masses of defects). The principle of minimal coupling explicitely used in 1969 by KLUGE for mechanical defects within a solid, being extended in 1983 by KADIC and EDELEN by the help of Yang-Mills-theory for introducing phenomenological terms of inertia for mechanical defects, is leading to the relation with the field theoretical masses for defects as in electrodynamics.Translated AbstractBemerkung über Gruppen und innere Struktur der KontiuumsmechanikDie mechanischen Bewegungen eines Festkörpers unterliegen der Gruppe der äußeren Bewegung (der Galileigruppe bzw. für eine relativistische Mechanik der Lorentzgruppe) sowie der davon unabhängigen inneren quasi Lorentzgruppe lq. Da sich der Einfluß der äußeren Gruppe immer durch ein System äußerer Kräfte simulieren läßt, unterliegen die inneren Eigenschaften der Gruppe lq (z. B. Quasimassen der Defekte). Das durch KLUGE 1969 auf die Strukturdefekte des Festkörpers übertragene Prinzip der minimalen Kopplung, was durch KADIĆ und EDELEN 1983 im Rahmen des Yang-Mills-Formalismus durch Einführung phenomenologischer Trägheitsterme für die Defekte erweitert wurde, führt auf die Frage nach dem Zusammenhang mit den feldtheoretischen Massen der Defekte in Analogie zur Elektrodynamik.

  19. Astronomy in High School: Using a Mini-Planetarium to Understand Details of the Apparent Movement of Stars. (Spanish Title: Astronomía en la Escuela Secundaria: Comprendiendo los Detalles del Movimiento Aparente de Las Estrellas con un Miniplanetario.) Astronomia no Ensino Médio: Compreendendo Detalhes do Movimento Aparente das Estrelas com um Miniplanetário

    NASA Astrophysics Data System (ADS)

    dos Santos Leão, Demetrius

    2013-07-01

    en la comprensión de estas cuestiones y demostraron un gran interés por esta metodología. O objetivo deste artigo é apresentar parte dos resultados obtidos com a intervenção feita como projeto da dissertação de mestrado do autor, que consistiu no desenvolvimento de um conjunto de aulas de Astronomia, com alunos do 1º Ano do Ensino Médio de uma escola da rede privada do Distrito Federal (Brasília, Brasil), empregando como recurso principal um material didático chamado miniplanetário (MP). Utilizando como pressuposto teórico norteador dessas aulas as ideias de contextualização e dialogicidade de Paulo Freire, foi proposta aos estudantes a montagem e utilização desse recurso em uma sessão de planetário. Durante o projeto, enfatizaram-se assuntos como a trajetória aparente das estrelas para o céu de Brasília, a localização dos pontos cardeais a partir da constelação do Cruzeiro do Sul, as cores das estrelas e as estrelas vistas de uma determinada localidade. Apurou-se que os alunos apresentaram melhoria na compreensão desses assuntos, bem como demonstraram expressiva empolgação com essa metodologia desenvolvida.

  20. Karstentwässerung im Kaisergebirge (Tirol, Österreich) - Abgrenzung hydrographischer Einzugsgebiete durch Kombination hydrogeologischer Untersuchungen mit Isotopenmethoden und hydrologischer Modellierung

    NASA Astrophysics Data System (ADS)

    Benischke, Ralf; Harum, Till; Reszler, Christian; Saccon, Pierpaolo; Ortner, Gerlinde; Ruch, Christophe

    2010-03-01

    Water resources investigations in karstic mountainous regions face the difficulty that the hydrological catchment boundaries are usually not identical with the orographic catchment boundaries. In this study an integrative method is presented that combines different sources of hydrogeological information and results of distributed water balance modelling to identify hydrological catchment boundaries and subsurface water ways in a karstic mountainous region. The different information comprises, in addition to meteorological and hydrographic data, region-wide point measurements of discharge, field surveys, isotope data, tracer tests, spring discharge data, soil and geological surveys and mapping, etc. The study was set-up in the Kaisergebirge mountain range in Tyrol/Austria, using the well known model MIKE SHE. Based on the additional information, the original model structure was adjusted to the specific situation in the karst, e.g. by introducing a bypass-flow within the unsaturated zone. The modelling results based on the orographic catchments were evaluated in terms of closure and—equally important—non-closure of the water balance. Spatial patterns of simulated hydrologic quantities are interpreted in light of the different sources of information. As a result, a regional map of surplus and deficit between observed and simulated runoff was drawn and combined with the additional information to form a general conceptual model of karst water flow directions and the location and altitude of the contributing recharge area in the high-alpine region. The results of the study provide a valuable basis for the assessment and protection of karst water resources for water supply.

  1. Erfolgsfaktoren von Lehrstellenmarketing in der dualen berufsbildung: das beispiel Schweiz

    NASA Astrophysics Data System (ADS)

    Sager, Fritz

    2006-09-01

    SUCCESS FACTORS OF APPRENTICESHIP MARKETING IN A SYSTEM OF DUAL VOCATIONAL TRAINING: THE CASE OF SWITZERLAND - The dual system of vocational training, utilizing both company training and vocational school, is generally acknowledged to be a successful model, but a decreasing number of trainee posts in Switzerland poses a crisis for the approach. One strategy for overcoming the problem involves offering incentives for companies to create new trainee posts. The present study explores the necessary conditions for successfully influencing the number of trainee posts through apprenticeship marketing. A comparision of qualitative case studies of six marketing projects demonstrates that while context, in the sense of basic structural conditions and political sensibility for the problematic, plays a role in the success of a project, what is central is above all the form of the trainee-post marketing project itself. This has to do with the behaviour of the actors involved as well as the choice of the mode of governance and project organization. The latter has to do with making available requisite technical and personal resources, coordination on the part of the project direction, and giving those responsible the necessary room to act in implementing the project.

  2. Vernetztes regionales Engagement - Das Beispiel Heilbronn-Franken

    NASA Astrophysics Data System (ADS)

    Suarsana, Laura; Glückler, Johannes

    2016-03-01

    At a regional scale, a variety of actors from all three sectors of private, public and civil society act together in a philanthropic field. This article deals with the question of how cooperation in charitable action unfolds in this field. Using the example of the region of Heilbronn-Franconia, the empirical case unpacks the dominance of local and regional forms of philanthropy and reconstructs two successful examples of intersectoral collaboration. However, the analysis also demonstrates the limits of the external designability that are due to the individuality of charitable actors, their diverse objectives and the contextuality of the regional environment. The realization of synergies through regional governance therefore succeeds only by respecting the dedication and self-determination of philanthropic commitment and by creating legitimate and sensitive structures of moderation and facilitation.

  3. Licht und Entwicklung — das Phytochromsystem der Pflanzen

    NASA Astrophysics Data System (ADS)

    Mohr, H.

    1981-04-01

    In photosynthetic green plants light is the decisive environmental factor. The terrestrial green plant is organized almost ideally in a way so as to absorb and process light quanta. The genetic adaptation to the factor, light, has taken place in the course of the genetic evolution (phylogeny) of terrestrial plants. However, light also affects the individual development (ontogeny) profoundly insofar as the genes which control normal development of a higher plant can only express themselves fully in the presence of light. Thus, the development of a higher plant (“photomorphogenesis”) is characterized by the obligatory interaction between genes and environment (light). The mechanisms of “transduction of light signals”, i.e. the biophysical and molecular events during photomorphogenesis, are described in the present article.

  4. Excising das All: Evolving Maxwell waves beyond Scri

    NASA Technical Reports Server (NTRS)

    vanMeter, James R.; Fiske, David R.; Misner, Charles W.

    2006-01-01

    We study the numerical propagation of waves through future null infinity in a conformally compactified spacetime. We introduce an artificial cosmological constant, which allows us some control over the causal structure near null infinity. We exploit this freedom to ensure that all light cones are tilted outward in a region near null infinity, which allows us to impose excision-style boundary conditions in our finite difference code. In this preliminary study we consider electromagnetic waves propagating in a static, conformally compactified spacetime.

  5. Solarzellen aus Folien-Silizium: Neue Materialien der Photovoltaik

    NASA Astrophysics Data System (ADS)

    Hahn, Giso

    2004-01-01

    Die Photovoltaik wird auf absehbare Zeit vor allem kristallines Silizium als Baumaterial nutzen, mit Tendenz zu billigeren, multikristallinen Wafern. Allerdings werden heutige Wafer aus großen Silizium-Blöcken gesägt, was viel Material verpulvert. Das treibt den Anteil des Wafers an den Gesamtkosten des Solarmoduls auf 50% hoch. Folien-Silizium nutzt dagegen durch eine andere Herstellungstechnik das Material viel besser aus und senkt so die Waferkosten erheblich. Im Wirkungsgrad können Solarzellen aus Folien-Silizium schon fast mit herkömmlichen Zellen konkurrieren. Ein weiterer Vorteil von Folien-Silizium: Es kann relativ problemlos in die Produktionslinien heutiger Solarzellen aus kristallinem Silizium eingegliedert werden. Allerdings sind die attraktivsten Herstellungsverfahren noch nicht serienreif.

  6. Victor F. Weisskopf (1908 - 2002): Physikgeschichte

    NASA Astrophysics Data System (ADS)

    Jacobi, Manfred

    2002-11-01

    Universal gebildete und interessierte Menschen sind selten geworden in unserer Zeit. Victor F. Weisskopf war einer von ihnen. Sein geistiger Horizont umfasste nicht nur sein eigentliches Fachgebiet, die Physik, wo er sich durch fundamentale Arbeiten in den Bereichen der Quantenfeldtheorie, der Kern- und Elementarteilchenphysik hervortat. Daneben bildeten Kunst und Musik sowie ein außergewöhnliches Engagement in sozialen und politischen Angelegenheiten die Eckpunkte seines Lebens. Der Einsatz für die Verständigung zwischen den Machtblöcken während des Kalten Krieges war für ihn ebenso selbstverständlich wie das Bedürfnis, die neuen Ideen der Physik einem breiten Publikum nahe zu bringen. Die Wissenschaft erschien ihm als das geeignete Mittel, um zum Wohle der Menschheit zu wirken.

  7. Strahlungsfeldbedingungen bei der Ionisationsdosimetrie

    NASA Astrophysics Data System (ADS)

    Krieger, Hanno

    Bei der Dosimetrie von Photonenstrahlungen mit luftgefüllten Ionisationskammern werden in diesem Kapitel zwei Grenzfälle unterschieden. Der eine Fall ist die Bedingung des so genannten Sekundärelektronengleichwichts im Kammervolumen. In diesem Fall bestimmen ausschließlich die Photonen im Messvolumen die dosimetrische Anzeige. Der zweite Grenzfall ist gegeben, wenn das Luftvolumen und die Kammer das Strahlungsfeld im Phantom so wenig stören, dass der Sekundärelektronenfluss unverändert bleibt. Diese Bedingungen nennt man BRAGG-GRAY-Bedingungen. Beide Grenzfälle sind in der Praxis nur näherungsweise zu verwirklichen. Abweichungen müssen durch entsprechende Korrekturen oder Kalibrierungen berücksichtigt werden.

  8. Magnesium

    NASA Astrophysics Data System (ADS)

    Bechtel, H.; Bulian, W.; Bungardt, K.; Gürs, K.; Gürs, U.; Helling, W.; Kyri, H.; Laue, H. J.; Mahler, W.; Matting, A.; Meyer, F. R.; Mialki, W.; Ritter, F.; Ruge, J.; Saur, G.; Simon, W.; Strnat, K.; Weber, R.; Weigand, H. H.; Weik, H.; Ziesler, H.; Borchers, Heinz; Schmidt, Ernst

    Magnesium wird überwiegend durch Schmelzflußelektrolyse hergestellt. Das dabei anfallende Reinmagnesium hat einen Mg-Gehalt von etwa 99,9%. Hauptbeimengung ist das Eisen; Silizium und Aluminium sind nur in Spuren vorhanden. Der Anwendungsumfang des Reinmagnesiums ist gering; dagegen werden Magnesiumlegierungen zunehmend, insbesondere für den Druckguß verwendet. Neben den bis etwa zum Jahre 1950 allein gebräuchlichen Mg-Mn-, Mg-Al- und Mg-Al-Zn-Legierungen werden heute mehr und mehr die besonders warmfesten Legierungen mit Zusätzen von Zirkon, Thorium und Seltenen Erden hergestellt (siehe dazu auch Abschnitt Seltene Erden). Als Umhüllungsmaterial für Uranstäbe dient die Legierung Magnox A 12, die nach [H 3] neben 1 % Al noch geringe Mengen an Ca und Ba enthält. In den in Deutschland üblichen Kurzzeichen (DIN 1729) werden die chemischen Symbole und der ungefähre Gehalt der wichtigsten Legierungselemente angegeben. Gußlegierungen werden zusätzlich durch ein G (Sandguß oder Kokillenguß) oder ein D (Druckguß) gekennzeichnet (siehe Tab. 5).

  9. Einleitung

    NASA Astrophysics Data System (ADS)

    Lange, Kurt

    Das Fließpressen zählt neben dem Stauchen und Gleitziehen zu den Kernverfahren des Kaltmassivumformens. In beschränktem Maße wird es auch im halbwarmen Bereich zwischen 600ºC und 800°C werkstoff- oder verfahrensbedingt angewandt. Besondere technisch-wirtschaftliche Bedeutung hat das Kaltfließpressen von Stahl erlangt, nachdem 1934 durch Phosphatieren der Rohteile nach dem Singer-Patent die sichere Umformung von Stahlwerkstoffen in Stahlwerkzeugen ohne Kaltverschweißen möglich geworden war. Die Werkstückmassen liegen beim Kaltfließpressen zwischen wenigen Gramm und einigen Kilogramm, seltener auch darüber. Grenzen sind die Werkzeugbelastung einerseits und die hohen Umformkräfte andererseits. Grundsätzlich lassen sich fast alle knetbaren Metalle durch Fließpressen umformen. Heute ist diese Verfahrensgruppe eine leistungsfähige Technologie, die die Fertigung präziser, geometrisch komplexer, hochbeanspruchbarer Werkstücke aus hochfesten Stählen für weite Einsatzbereiche mit geringstem Werkstoffeinsatz ermöglicht.

  10. High School Student's Alternative Conceptions About the Phenomenon of the Formation of the Moon Phases. (Spanish Title: Concepciones Alternativas de Alumnos de Educación Media Sobre el Fenómeno de Formación de las Fases de La Luna.) Concepções Alternativas de Alunos do Ensino Médio Sobre o Fenômeno de Formação das Fases da Lua

    NASA Astrophysics Data System (ADS)

    Iachel, Gustavo; Langhi, Rodolfo; Fernandes Scalvi, Rosa Maria

    2008-07-01

    Forty students, at ages between 14 and 18 years old, from three schools in Bauru city, were questioned about their alternative conceptions concerning the phenomenon of formation of the Moon Phases. It was observed that some of the pupils confound the phenomenon of the formation of the Moon Phases with the phenomenon of the formation of the lunar eclipses, others are unaware of the reason of the phenomenon, they present incoherent alternative conceptions of the reality or incomplete conceptions. The results found here are aimed at the teachers of Elementary Education and can be used as a subsidy for future development of new pedagogical methods. Cuarenta estudiantes, con edad entre 14 y 18 años, pertenecientes a tres escuelas de la ciudad de Bauru, fueron cuestionados sobre sus concepciones alternativas acerca del fenómeno de la formación de las fases de la Luna. Fue observado que algunos alumnos confunden el fenómeno de formación de las fases de la Luna con el fenómeno de formación de los eclipses lunares, otros desconocen el motivo delfenómeno, presentan concepciones alternativas incoherentes con la realidad o bien presentan concepciones incompletas. Los resultados aquí encontrados son destinados a los profesores de la Enseñanza Básica y podrán ser usados como ayuda para el futuro desarrollo de nuevos métodos pedagógicos. Quarenta estudantes, com idades entre 14 e 18 anos, pertencentes a três escolas da cidade de Bauru, foram questionados sobre suas concepções alternativas acerca do fenômeno de formação das fases da Lua. Foi observado que alguns dos alunos confundem o fenômeno da formação das fases da Lua com o fenômeno da formação dos eclipses lunares, outros desconhecem o motivo do fenômeno, apresentam concepções alternativas incoerentes com a realidade ou então concepções incompletas. Os resultados aqui encontrados são destinados aos professores do Ensino Básico e poderão ser usados como subsídio parafuturo desenvolvimento de

  11. Lane Keeping Support

    NASA Astrophysics Data System (ADS)

    Gayko, Jens

    Während längerer Fahrten auf autobahnähnlichen Straßen wird die Fahraufgabe des Spurhaltens von vielen Fahrern als lästig empfunden. Andererseits stellt das unbeabsichtigte Verlassen des Fahrstreifens eine häufge Unfallursache dar, wie bereits in Kapitel 34 beschrieben. Im Gegensatz zu der im vorigen Kapitel dargelegten Funktion des Lane Departure Warning (LDW) greift die hier beschriebene Spurhalteassistenz bzw. Lane Keeping Support (LKS) aktiv in das Lenksystem ein. Dadurch wird der Fahrer bei der Fahraufgabe des Spurhaltens unterstützt. Ziel dieser Funktion ist, je nach Auslegung, eine Erhöhung der Sicherheit, eine Erhöhung des Fahrkomforts oder eine Kombination beider Ziele. Ein wichtiges Merkmal der hier beschriebenen Systeme ist die Art der Assistenz, die über Warnungen hinausgeht, jedoch keine den Fahrer ersetzende Assistenz darstellt. Die motorische Ausführung der Lenkung des Fahrzeugs erfolgt somit durch den Fahrer und das LKS-System zugleich. Das Einsatzgebiet der heute verfügbaren Systeme erstreckt sich über autobahnähnliche Straßen in mittleren bis hohen Geschwindigkeiten und sichtbaren Markierungen der Fahrstreifen.

  12. Werner-Syndrom. Eine prototypische Form der segmentalen Progerie

    PubMed Central

    Lessel, D.; Oshima, J.; Kubisch, C.

    2013-01-01

    Das Werner-Syndrom ist eine segmental progeroide Erkrankung mit Beginn in der Adoleszenz oder im frühen Erwachsenenalter. Typische Symptome, die zum vorgealterten Phänotyp beitragen, sind ein post-pubertär auftretender Kleinwuchs, Katarakte, eine vorzeitige Ergrauung/Ausdünnung des Haupthaars, sklerodermieähnliche Hautveränderungen und eine regionale Atrophie des subkutanen Fettgewebes. Darüber hinaus kommt es früh und gehäuft zu „Alterserkrankungen“ wie z. B. einem Diabetes mellitus Typ 2, einer Osteoporose, einer Atherosklerose sowie verschiedenen malignen Tumoren. Das Werner-Syndrom wird autosomal- rezessiv vererbt und ist durch Mutationen im Werner-Gen (WRN) bedingt. Es wurden bis heute mehr als 70 über das gesamte Gen verteilte Mutationen identifiziert, die typischerweise zu einem Verlust der Genfunktion führen. WRN kodiert für eine RecQ-Typ- Helikase, die u. a. an der DNA-Reparatur und der Aufrechterhaltung der DNA-Integrität beteiligt ist, was sich in einer erhöhten genetischen Instabilität in Patientenzellen wider-spiegelt. Trotz der relativen Seltenheit ist die Analyse des Werner-Syndroms von allgemeiner Bedeutung, um die Rolle der DNA-Stabilität und Integrität für das Altern sowie die Entwicklung altersassoziierter Erkrankungen besser zu verstehen. PMID:25309043

  13. Memories of Astronomy Education in Brazil: Clippings from the Discourses of Interviewed Researchers on the Subject. (Spanish Title: Memorias de la Educación en Astronomía en Brasil: Recortes de los Discursos de Investigadores Entrevistados Acerca del Tema ) Memórias da Educação em Astronomia no Brasil: Recortes a Partir das Falas de Pesquisadores Entrevistados sobre o Tema

    NASA Astrophysics Data System (ADS)

    Iachel, Gustavo; Nardi, Roberto

    2014-12-01

    This paper presents a historical retrospective concerning data from a research in Astronomy Education in Brazil, after 1973. It was organized on the basis of the speech analysis of national researchers considered references in this field by their peers. Furthermore, it was elaborated on the basis of other studies from the areas of Science Education, Physics and Astronomy. This historical overview was developed in order to facilitate understanding of the contexts in which the interviewed researchers have developed professionally. Moreover, we attempted to recover the memory of the growing field of research in Astronomy Education in the country. We believe that the history presented can help those trying to understand the past in an attempt to resolve current and future demands. Se presenta en este artículo una retrospectiva histórica referente a datos provenientes de la investigación en enseñanza de la astronomía en el Brasil, después de 1973, organizada sobre la base del análisis de los discursos de los investigadores nacionales considerados referencias en este campo, y también en la lectura de las publicaciones en las áreas de Enseñanza de las Ciencias, Física y Astronomía. Este repaso histórico se desarrolló con el fin de facilitar la comprensión de los contextos en los que los investigadores entrevistados se han desarrollado profesionalmente. Por otra parte, se intentó recuperar la memoria del creciente campo de la investigación en Educación en Astronomía en el país. Creemos que el relato presentado puede contribuir a quien trata de comprender el pasado, en un intento de resolver las demandas actuales y futuras. Relata-se neste artigo uma retrospectiva histórica referente a dados provenientes de pesquisa em Educação em Astronomia no país, pós 1973, organizada com base na análise das falas de pesquisadores considerados referências nacionais nesse campo, como também na leitura de publicações das áreas de ensino de Ciências, F

  14. Data-Mining für die Angebotsoptimierung im Handel

    NASA Astrophysics Data System (ADS)

    Garcke, Jochen; Griebel, Michael; Thess, Michael

    Der Handel ist weltweit durch gravierenden Wettbewerbsdruck gekennzeichnet. Deutschland gilt im Einzelhandel sogar als der wettbewerbsintensivste Markt der Welt. Um in diesem Wettbewerb zu bestehen, vertrauen die meisten Händler auf extensive Formen ungezielten Massenmarketings. Hierbei werden alle potentielle Kunden mit den gleichen riesigen Katalogen, ungezählten Werbebroschüren, aufdringlichen Lautsprecherdurchsagen und schrillen Bannerwerbungen bearbeitet. Im Ergebnis sind nicht nur die Kunden genervt, sondern auch die Rücklaufraten von Marketingkampagnen seit Jahren fallend. Um dies zu vermeiden, ist eine Individualisierung des Massenmarketings empfehlenswert, in der Kunden auf sie zugeschnittene, individuelle Angebote erhalten. Die Aufgabe besteht darin, dem richtigen Kunden zum richtigen Zeitpunkt zum richtigen Preis das richtige Angebot zu unterbreiten. Dies stellt sich primär als eine mathematische Aufgabenstellung heraus, die die Bereiche Statistik, Optimierung, Analysis und Numerik betrifft. Die hierbei auftretenden Aufgabenstellungen der Regressionsanalyse, des Clusterings und der Optimalen Steuerung sind durch hohe Dimensionen und riesige Datenmengen gekennzeichnet und erfordern neue mathematische Konzepte und Verfahren.

  15. Implantate im Mittelohrbereich - Teil 2 (Ergänzungen 2007)

    NASA Astrophysics Data System (ADS)

    Stieve, M.; Lenarz, Thomas

    In Deutschland leben ca. 12 Millionen Menschen, die an einer ein- oder beidseitigen Schwerhörigkeit leiden. Diese kann angeboren oder im Laufe des Lebens erworben sein. Klinisch und therapeutisch wichtig ist die Unterscheidung hinsichtlich des Schädigungsortes im Bereich des Mittelohres, d. h. eine Schalleitungsschwerhörigkeit, oder im Bereich des Innenohres, d. h. eine Schallempfindungsschwerhörigkeit, wobei hier der Schädigungsort auch am Hörnerven oder in den zentralen Hörabschnitten liegen kann. Therapeutisch lassen sich sowohl Schwerhörigkeiten im Bereich des Mittelohres als auch im Innenohr und sogar im Hirnstammbereich (Hirnstammimplantat) behandeln. 1,9 Millionen Schwerhörige haben eine Erkrankung im Mittelohrbereich, d. h. der Schall kann nur ungenügend auf das Innenohr übertragen werden. Die Ursache besteht meist in einer chronischen Mittelohrentzündung, die zu einer Zerstörung des Trommelfells und der Gehörknöchelchenkette geführt haben. Therapeutisch und damit als Prinzip der operativen Hörverbesserung steht primär der Verschluß des Trommelfells oder eine Rekonstruktion der Gehörknöchelchen. Mittelohroperationen werden mikrochirurgisch unter dem Operationsmikroskop durchgeführt, wobei zunächst durch eine sanierende Operation der Entzündungsprozeß entfernt wird und nach einer Ausheilungszeit die Gehörknöchelchenkette durch künstliche Prothesen rekonstruiert werden kann.

  16. Kooperative Automation

    NASA Astrophysics Data System (ADS)

    Hakuli, Stephan; Bruder, Ralph; Flemisch, Frank O.; Löper, Christian; Rausch, Herbert; Schreiber, Michael; Winner, Hermann

    Das Aufgabenspektrum moderner Assistenzsyseme erstreckt sich von der Steigerung des Fahrkomforts bis hin zur Übernahme aktiver Sicherheitsfunktionen. Selbst komplexe Systeme wie die adaptive Fahrgeschwindigkeitsregelung ACC (Adaptive Cruise Control, vgl. Kap. 32), die wie viele weitere Innovationen in der Fahrzeugindustrie einst der automobilen Oberklasse vorbehalten war, dringen derzeit über die Mittelklasse in den Massenmarkt vor und beginnen, die Öffentlichkeit für die mit hoher Automatisierung einhergehenden Veränderungen und Herausforderungen zu sensibilisieren. Denn so beeindruckend die Leistungsfähigkeit moderner Fahrerassistenzsysteme auch ist, so verursacht sie doch ein Dilemma: Mit der Übernahme von primären Fahraufgaben durch Fahrerassistenzsysteme werden vom Fahrer neue und erweiterte Bedienfähigkeiten erwartet. Zum einen muss er ein mentales Modell eines jeden vorhandenen Assistenzsystems mit dessen spezifscher Mensch-Maschine-Schnittstelle aufbauen und dessen funktionale Grenzen verinnerlichen. Zum anderen muss er, nachdem er einen Teil seiner Fahraufgabe an ein Assistenzsystem übertragen hat, die (teil-)automatisierte Funktion überwachen, die Handlungen des Systems antizipieren und eine permanente Bereitschaft zur Rückübernahme der durch die Assistenzfunktion ausgeführten Fahraufgabe aufweisen. Die Rückübernahme geschieht entweder willentlich, wenn die Unterstützung nicht nach des Fahrers Vorstellung verläuft, oder sie ist obligatorisch, wenn die Assistenzfunktion an ihre funktionalen Grenzen stößt und explizit zur Übernahme auffordert.

  17. > Einleitung

    NASA Astrophysics Data System (ADS)

    Spath, Dieter; Pischetsrieder, Bernd

    Rund 40 Prozent aller Fahrzeuge fahren elektrisch. Ein Zustand, der aus heutiger Sicht noch in weiter Ferne liegt, war vor über 100 Jahren bereits Realität. Um 1900, einige Jahre nach der Erfindung des Automobils, wurden Fahrzeuge durch unterschiedliche Antriebskonzepte angetrieben. Die drei wichtigsten waren Dampfantrieb, Elektroantrieb und der Benzinmotor. Durch die überlegene Energiedichte und eine kostengünstige sowie scheinbar unendliche Verfügbarkeit des Energieträgers Öl entwickelte sich der Verbrennungsmotor zum dominanten Antriebskonzept. Der Einsatz von Elektrofahrzeugen beschränkte sich im Verlauf des 20. Jahrhunderts auf wenige Nischenanwendungen. Der verbrennungsmotorbasierte Antriebsstrang ist dem Elektroantrieb auch heute noch technisch und ökonomisch überlegen. Die Randbedingungen ändern sich jedoch. Die Verknappung des fossilen Brennstoffs Öl und die stetige Verschärfung der CO2-Emissionsziele in Verbindung mit einer starken Zunahme individueller Mobilität im asiatischen Raum und vielen weiteren Regionen der Welt stellen den Verbrennungsmotors als die dominante Antriebstechnologie in Frage. Trotz des Optimierungspotentials, welches auch nach über 120-jähriger Entwicklung noch im Verbrennungsmotor liegt, ist diese Technologie immer mit lokalen Schadstoff- und Lärmemissionen verbunden. Die Notwendigkeit der Reduktion von Treibhausgasen verbunden mit einem steigenden Urbanisierungsgrad wird in Zukunft einen Technologiewechsel vom Verbrennungsmotor zum elektrischen Antrieb attraktiv machen. Dieser Technologiewechsel bedeutet jedoch weit mehr als das Austauschen des Antriebsstranges, Elektromobilität ist ein komplexes Themengebiet mit unterschiedlichen Dimensionen.

  18. Zuverlässigkeit digitaler Schaltungen unter Einfluss von intrinsischem Rauschen

    NASA Astrophysics Data System (ADS)

    Kleeberger, V. B.; Schlichtmann, U.

    2011-08-01

    Die kontinuierlich fortschreitende Miniaturisierung in integrierten Schaltungen führt zu einem Anstieg des intrinsischen Rauschens. Um den Einfluss von intrinsischem Rauschen auf die Zuverlässigkeit zukünftiger digitaler Schaltungen analysieren zu können, werden Methoden benötigt, die auf CAD-Verfahren wie Analogsimulation statt auf abschätzenden Berechnungen beruhen. Dieser Beitrag stellt eine neue Methode vor, die den Einfluss von intrinsischem Rauschen in digitalen Schaltungen für eine gegebene Prozesstechnologie analysieren kann. Die Amplituden von thermischen, 1/f und Schrotrauschen werden mit Hilfe eines SPICE Simulators bestimmt. Anschließend wird der Einfluss des Rauschens auf die Schaltungszuverlässigkeit durch Simulation analysiert. Zusätzlich zur Analyse werden Möglichkeiten aufgezeigt, wie die durch Rauschen hervorgerufenen Effekte im Schaltungsentwurf mit berücksichtigt werden können. Im Gegensatz zum Stand der Technik kann die vorgestellte Methode auf beliebige Logikimplementierungen und Prozesstechnologien angewendet werden. Zusätzlich wird gezeigt, dass bisherige Ansätze den Einfluss von Rauschen bis um das Vierfache überschätzen.

  19. Ray effects in the discrete-ordinate solution for surface radiation exchange

    NASA Astrophysics Data System (ADS)

    Liou, B.-T.; Wu, C.-Y.

    A study of the application of the discrete-ordinate method (DOM) with remedy for the ray effects to the solution of surface radiation exchange is presented in this paper. The remedy for the ray effects is achieved by dividing the radiative intensity into the attenuated incident and the medium emitting components. To demonstrate the application of the technique, this work considers radiative heat transfer in a two-dimensional cylindrical enclosure filled with a nearly transparent medium. The results obtained by the present DOM are in excellent agreement with those by the radiosity/irradiation method. Zusammenfassung In der Arbeit wird ein Weg aufgezeigt, wie die Störstrahlungseffekte bei Anwendung der Methode der diskreten Ordinaten auf die Berechnung des Energietausches zwischen Oberflächenstrahlern vermieden werden können. Dies läßt sich durch Aufspaltung der Strahlungsintensität in die abgeschwächte einfallende und die vom Medium emittierte Komponente erreichen. Als Beispiel für die Anwendung dieses Verfahrens dient der Wärmeaustausch durch Strahlung in einem zweidimensionalen zylindrischen Behältnis, das mit einem nahezu transparenten Medium befüllt ist. Die mit der modifizierten Methode erhaltenen Ergebnisse stimmen ausgezeichnet mit jenen nach dem klassischen Brutto-Verfahren überein.

  20. Vom GIS zur Geodateninfrastruktur

    NASA Astrophysics Data System (ADS)

    Greve, Klaus

    2002-09-01

    Geographische Informationssysteme sind nicht mehr ausschließlich ein Werkzeug für Spezialisten. In immer mehr Bereichen der raumbezogenen Dokumentation, Planung und Analyse werden diese Werkzeuge eingebunden. Der Beitrag beschreibt die Entwicklung und analysiert die technologischen Hintergründe. Viel wichtiger als technologische Veränderungen aber sind organisatorische und gesellschaftliche Veränderungen, die auf dem Wege zur Informations- und Wissensgesellschaft eine neue Bewertung des Nutzens von Geoinformation bewirken. Geoinformation wird zunehmend als Wirtschaftsgut betrachtet, das am Markt gehandelt werden kann und ein erhebliches Wirtschaftspotential aufweist. Allerdings ist der Markt für Geoinformationen durch Strukturen geprägt, die die Nutzung des wirtschaftlichen Potentials deutlich behindern. Geodateninfrastrukturen gelten als ein wichtiges Instrument zur Überwindung der Marktbarrieren und zur Etablierung neuartiger Wertschöpfungsketten und innovativer Jobchancen für Experten für die Veredlung und Verdichtung von raumbezogenen Informationen.

  1. Vorausschauend Planen, Gezielt Handeln — Über Die Regelung Und Steuerung Technischer Prozesse

    NASA Astrophysics Data System (ADS)

    Grüne, Lars; Sager, Sebastian; Allgöwer, Frank; Bock, Hans Georg; Diehl, Moritz

    Seit Beginn der industriellen Revolution nimmt die Steuerungs- und Regelungstechnik eine Schlüsselstellung in vielen technischen Bereichen ein. James Watts Fliehkraftregler für Dampfmaschinen ist eines der frühen Beispiele eines extrem erfolgreichen Reglerkonzepts, von dem Ende der 1860er Jahre geschätzte 75000 Exemplare allein in England im Einsatz waren [2, S. 24]. Etwa um diese Zeit begannen Ingenieure, motiviert durch die immer höhere Komplexität der zu regelnden Maschinen, sich systematisch mit theoretischen Grundlagen der Regelung zu beschäftigen. Dies führte unausweichlich zu der Einsicht, dass das dynamische Verhalten der geregelten Systeme nur mit Hilfe der Mathematikverstanden und weiterentwickelt werden konnte, oder wie Werner von Siemens, ein weiterer technischer Pionier in diesem Bereich es formulierte: "Ohne Mathematik tappt man doch immer im Dunkeln.“

  2. Bewegungsapparat: Postcraniales Skelett und Muskulatur

    NASA Astrophysics Data System (ADS)

    Fischer, Martin S.

    Der Bewegungsapparat bestimmt die Form des Wirbeltierkörpers. So lässt sich z. B. aus der Gestalt eines Fisches auf seine bevorzugt e Schwimmweise schließen (S. 61). Bei den aquatisch en Schädeltieren dominiert die Fortbewegung mit axialem Antrieb; bei den meisten Tetrapoda findet sich eine Kombination aus axialem Antrieb und Bewegung durch Gliedmaßen. Selbst beim höchst spezialisierten Gang, der bipeden Bewegung des Menschen, sind Torsionsbewegungen des Rumpfes noch maßgeblich und bestimmen auch die Grundform des menschlichen Körpers (z. B. die Taille). Obwohl die verschiedenen Antriebsmechanismen eine funktionelle Einheit bilden, werden im Folgenden das Axialskelett sowie der Schulter- und Beckengürtel mit den zugehörigen Extremitäten getrennt besprochen.

  3. Turbulenzübergang in der Rohrströmung: Die Lösung eines alten Rätsels

    NASA Astrophysics Data System (ADS)

    Eckhardt, Bruno; Hof, Björn; Faisst, Holger

    2006-09-01

    Die Strömung von Flüssigkeiten und Gasen durch eine Röhre kann zwei Zustände annehmen. Einer ist laminar, also gleichmäßig geordnet, einer ist zeitlich-räumlich verwirbelt und turbulent. Mit dem Übergang zur Turbulenz nimmt der Strömungswiderstand drastisch zu. Vor etwa 120 Jahren beschrieb Osborne Reynolds bereits das Verhalten der Rohrströmung sehr genau. Er beobachtete, dass der Turbulenzübergang sehr empfindlich von äußeren Störungen abhängt, was bislang rätselhaft blieb. Dieses Rätsel konnte nun mit einer Kombination aus Computerstudien, Konzepten aus der nichtlinearen Dynamik und speziell entwickelten Experimenten gelöst werden.

  4. Der Forsch-Frosch Fred

    NASA Astrophysics Data System (ADS)

    Kaibel, Volker

    Bewegt man sich auf der Suche nach Informationen zu einem bestimmten Thema immer neuen Links folgend durch das World-Wide-Web, so stellt man in der Regel nach einer gewissen Zeit fest, dass man auf manchen Seiten immer wieder gelandet ist. Diese Seiten stellen sich oft als wichtig heraus. Suchmaschinen wie Google machen sich dieses Phänomen zu Nutze, um die Wichtigkeit einzelner Web-Seiten zu bewerten. Dazu lassen sie auf einer beliebigen Web-Seite einen imaginären Surfer starten, der immer zufällig einen der auf seiner aktuell besuchten Seite vorgefundenen Links verfolgt. Der Surfer vollführt einen Random Walk im Netzwerk der Web-Seiten.

  5. IntegraTUM Teilprojekt E-Mail: Rezentralisierung von E-Mail-Services

    NASA Astrophysics Data System (ADS)

    Diehn, Max; Haarer, Ado; Schreiner, Alexander; Storz, Michael

    Das Teilprojekt E-Mail hatte ursprünglich die Aufgabe einen zentralen Mailservice mit verteilter Administration der Mailadressen für die TUM aufzubauen und diesen durch Anti-Spam- und Anti-Viren-Maßnahmen zu schützen. Auf diesen Mailservice sollten sowohl die am LRZ gehosteten Maildomains als auch die vielen lokal betriebenen Mailserver - soweit von deren Betreibern gewünscht - migriert werden. Neben einigen Rückschlägen und Hindernissen kam es im Laufe des Projektes auch zu einer Änderung der Anforderungen, sodass zum Ende des Projektes statt eines reinen Mailsystems ein Doppelsystem mit "shared SMTP address space" bestehend aus einem klassischen Message-Store mit POP/IMAP-Zugriff auf Basis von Postfix + Dovecot und einem Groupware-System auf Basis von Microsoft Exchange in Produktion ging, wobei jeder Mitarbeiter und Student der TUM wählen kann, auf welchem der beiden Systeme sich seine Mailbox befindet.

  6. Halbautomatische Segmentierung von Pulmonalgefäßen in CT Daten als Referenz zur Validierung automatischer Verfahren

    NASA Astrophysics Data System (ADS)

    Kaftan, Jens N.; Bakai, Annemarie; Maier, Florian; Aach, Til

    Das Segmentieren von Pulmonalgefäßen in Computertomographie (CT) Daten wurde schon vielfach behandelt und wird z.B. bei der computerunterstützten Detektion von Lungenembolien angewendet. Vielen Segmentierverfahren fehlt jedoch eine quantitative Validierung aufgrund mangelnder Referenzsegmentierungen. Wir stellen ein System zur halbautomatischen Segmentierung von Blutgefäßen in definierten Bereichen der Lunge basierend auf dem Random-Walker-Algorithmus vor. Durch Initialisierung der Methode mittels automatisch generierter Saatpunkte wird die Effizienz des Verfahrens erhöht und die erforderliche Benutzerinteraktion reduziert. Die resultierenden Segmentierungen können zur Validierung von automatischen Verfahren verwendet werden. Exemplarisch evaluieren wir ein vollautomatisches Segmentierverfahren basierend auf dem Fuzzy-Connectedness-Algorithmus.

  7. Transporterscheinungen

    NASA Astrophysics Data System (ADS)

    Heintze, Joachim

    In diesem Kapitel werden wir uns vornehmlich mit zwei Vorgängen befassen, ohne die das Erreichen des thermischen Gleichgewichts und die Veränderung des thermischen Zustands eines Systems unmöglich wäre: Wärmeleitung und Diffusion. Bei der Wärmeleitung wird die kinetische Energie der Teilchen durch Stöße auf die Nachbarn übertragen: Es handelt sich um den Transport von Wärmeenergie. Unter Diffusion versteht man den Transport von Molekülen aufgrund ihrer Wärmebewegung. Sie tritt in Erscheinung, wenn in einem System verschiedene Arten von Molekülen vorhanden und ungleichmäßig verteilt sind.

  8. VDI-Richtlinien - mit Technischen Regeln Wirtschaftlichkeit erhöhen und Standards setzen

    NASA Astrophysics Data System (ADS)

    Mandelartz, Johannes

    Der Verein Deutscher Ingenieure e.V. (VDI) ist ein gemeinnütziger, wirtschaftlich und politisch unabhängiger, technisch-wissenschaftlicher Verein von Ingenieuren und Naturwissenschaftlern. Mit über 137 000 persönlich zugeordneten Mitgliedern ist er eine der größten Ingenieur-Vereinigungen Europas und gilt in Deutschland als führender Sprecher der Technik und der Ingenieure. 1856 gegründet, hat er viele für die Technik wesentliche Entwicklungen in Gang gesetzt, so im Bereich der technischen Überwachung, der technischen Regelsetzung und Normung, der Arbeitsstudien, im gewerblichen Rechtsschutz und im Patentwesen. Seit seiner Gründung sieht es der VDI als seine Aufgabe, "das Zusammenwirken aller geistiger Kräfte der Technik im Bewusstsein ethischer Verantwortung zu fördern“ und die Lebensmöglichkeiten aller Menschen durch Entwicklung und sinnvoller Anwendung technischer Mittel zu verbessern.

  9. Realisierung eines verzerrungsarmen Open-Loop Klasse-D Audio-Verstärkers mit SB-ZePoC

    NASA Astrophysics Data System (ADS)

    Schnick, O.; Mathis, W.

    2007-06-01

    In den letzten Jahren hat die Entwicklung von Klasse-D Verstärkern für Audio-Anwendungen ein vermehrtes Interesse auf sich gezogen. Eine Motivation hierfür liegt in der mit dieser Technik extrem hohen erzielbaren Effizienz von über 90%. Die Signale, die Klasse-D Verstärker steuern, sind binär. Immer mehr Audio-Signale werden entweder digital gespeichert (CD, DVD, MP3) oder digital übermittelt (Internet, DRM, DAB, DVB-T, DVB-S, GMS, UMTS), weshalb eine direkte Umsetzung dieser Daten in ein binäres Steuersignal ohne vorherige konventionelle D/A-Wandlung erstrebenswert erscheint. Die klassischen Pulsweitenmodulationsverfahren führen zu Aliasing-Komponenten im Audio-Basisband. Diese Verzerrungen können nur durch eine sehr hohe Schaltfrequenz auf ein akzeptables Maß reduziert werden. Durch das von der Forschungsgruppe um Prof. Mathis vorgestellte SB-ZePoC Verfahren (Zero Position Coding with Separated Baseband) wird diese Art der Signalverzerrung durch Generierung eines separierten Basisbands verhindert. Deshalb können auch niedrige Schaltfrequenzen gewählt werden. Dadurch werden nicht nur die Schaltverluste, sondern auch Timing-Verzerrungen verringert, die durch die nichtideale Schaltendstufe verursacht werden. Diese tragen einen großen Anteil zu den gesamten Verzerrungen eines Klasse-D Verstärkers bei. Mit dem SB-ZePoC Verfahren lassen sich verzerrungsarme Open-Loop Klasse-D Audio-Verstärker realisieren, die ohne aufwändige Gegenkopplungsschleifen auskommen. Class-D amplifiers are suiteble for amplification of audio signals. One argument is their high efficiency of 90% and more. Today most of the audio signals are stored or transmitted in digital form. A digitally controlled Class-D amplifier can be directly driven with coded (modulated) data. No separate D/A conversion is needed. Classical modulation schemes like Pulse-Width-Modulation (PWM) cause aliasing. So a very high switching rate is required to minimize the aliasing component within the signal

  10. Volkszählung und Mikrozensus1

    NASA Astrophysics Data System (ADS)

    Grohmann, Heinz

    Die Volkszählung (Zensus) ist seit langem weltweit eine statistische Erhebung über Bevölkerung und Erwerbstätigkeit. In vielen Ländern wird sie heute in etwa 10jährigem Abstand durchgeführt. In Deutschland wurde sie in den 80er Jahren zum Politikum. Datenschutzängste, verbunden mit politischen Vorgängen (Friedensbewegung), erregten die Menschen, und das Bundesverfassungsgericht steckte neue Grenzen ab. Nach kontroversen Auseinandersetzungen, an denen die Deutsche Statistische Gesellschaft (DStatG) konstruktiv beteiligt war, kam es zur Volkszählung 1987. Den nachfolgenden Paradigmenwechsel hin zu einem registergestützten Zensus 2011 hat die DStatG ebenfalls kreativ mitgestaltet. Im Beitrag wird dieser Weg nachgezeichnet. Das neue Konzept wird vorgestellt und kritisch gewürdigt. Betroffen war auch der Mikrozensus als größte Bevölkerungs- und Arbeitsmarktstichprobe zwischen den Zensen. Nicht zuletzt durch das Wirken eines wissenschaftlichen Beirats, dessen Mitglieder von der DStatG vorgeschlagen wurden, blieb diese Erhebung in ihrem Kern für die Zukunft erhalten.

  11. On the Epistemological Status of Cosmology Anthropic Principle, Cosmological Numbers, and the Subject of Cosmology

    NASA Astrophysics Data System (ADS)

    Wahsner, Renate

    It is shown that cosmology destroys the fundamental on which it lies as a natural-scientific discipline if it introduces subjectivistic principles as one of them is the so-called Anthropic Principle that superseds the Copernican turn of sciences. Likewise conceptions are proved as conceptions that contradict the physical cosmology which conceive that the World harmony or the physical-uniform grasping of the world can be derived from numbers or relations of numbers. This is due to the fact that these conceptions liquadate the advantage of physics to get via measurements statements about reality.Translated AbstractZum epistemologischen Status der Kosmologie Anthropisches Prinzip, kosmologische Zahlen und der Gegenstand der KosmologieEs wird gezeigt, daß die Kosmologie das Fundament, auf dem sie als naturwissenschaftliche Disziplin beruht, zerstört, wenn sie subjektorientierte Grundsätze wie das Anthropische Prinzip einführt, die das copernicanische Prinzip aufheben. Desgleichen werden Konzepte, die davon ausgehen, daß die Harmonie der Welt oder die physikalisch einheitliche Fassung der Welt aus Zahlen oder Zahlenverhältnissen abgeleitet werden kann, als Konzepte nachgewiesen, die der physikalischen Kosmologie widersprechen, da sie den Vorzug der Physik, durch Messungen Aussagen über die Wirklichkeit zu gewinnen, liquidieren.

  12. Zahlen und Rechenvorgänge auf unterschiedlichen Abstraktionsniveaus

    NASA Astrophysics Data System (ADS)

    Rödler, Klaus

    "Das Verständnis geht langsam vor sich!" Diesen wichtigen Satz hörte ich bei einem Vortrag von Martin Lowsky. Auf die hier behandelte Fragestellung übertragen heißt das: Was eine Zahl ist und wie ich sie im Rechenvorgang einsetzen und interpretieren kann, das erschließt sich erst allmählich. Die Zahl des Rechenanfängers ist nicht dieselbe wie die des kompetenten Rechners und es ist nicht die Zahl des Lehrers oder der Lehrerin. Die Zahlen sind nur auf der Oberfläche der Worte und Zeichen gleich. Im Innern, im Verständnis, sind sie völlig verschieden! Ich glaube, dass die Missachtung dieser Divergenz dazu führt, dass manche Kinder in für den Lehrer und Lehrerin nicht nachvollziehbaren Routinen stecken bleiben, einfachste Informationen nicht wirklich integrieren. Die auf beiden Seiten wachsende Verunsicherung durch die nicht erkannte und daher nicht kommunizierbare Diskrepanz im inneren Zahlkonzept stört den allmählichen Aufbau strukturierter Zahlvorstellungen.

  13. Sternbilder und ihre Mythen

    NASA Astrophysics Data System (ADS)

    Fasching, Gerhard

    Die Sternbilder, die seit alters her die Menschen in ihren Bann gezogen haben, und die damit verbundenen Mythen werden in zweifacher Weise vorgestellt. Erstens ist es die Absicht, dem Leser zu helfen, sich am Sternenhimmel zurechtzufinden, und zweitens will es ihm die Vielfalt der Bilder vermitteln, die damit verbunden sind. Am Anfang des Buches stehen die prächtigen Erzählungen aus Ovids Metamorphosen. Dann ist vom Sternenhimmel im Jahreskreis die Rede, um den Leser anzuregen, diesen fast unendlichen Bilderreichtum sich selbst durch eigene Beobachtungen zu erschließen. Ein umfangreicher Abschnitt behandelt die einzelnen Sternbilder und das hierzu überlieferte Wissen. Sternkarten und alte Kupferstiche aus dem Bestand der Österreichischen Nationalbibliothek zeigen, wie man sich in früheren Jahrhunderten den Sternenhimmel vorgestellt hat. Sternsagen und Mythen werden erzählt und auch das ptolemäische und das kopernikanische Weltsystem werden einander gegenübergestellt. Ausführliche Sachverzeichnisse mit über 3000 Suchbegriffen erleichtern den Zugang zu Stern- und Sternbildnamen und zur Mythologie.

  14. Pathogene Mikroorganismen

    NASA Astrophysics Data System (ADS)

    Wagner, Martin

    Infektionen, die vom Tier auf den Menschen übertragen werden, werden als Zoonosen bezeichnet. Pathogene Mikroorganismen können entweder durch Mensch-Mensch, Mensch-Tier-Kontakt oder durch Kontakt mit kontaminierten Vektoren übertragen werden [39]. Vektoren können einerseits belebt (z. B. blutsaugende Insekten), andererseits unbelebt sein. Kontaminierte Lebensmittel und Wasser gehören zu den wichtigsten unbelebten Vektoren. Neben Lebensmitteln können aber auch kontaminierte Gegenstände oder der Kontakt mit Kontaminationsquellen in der Umwelt Auslöser von Krankheitsfällen sein. Weltweit sind mehr als 1400 krankheitsverursachende biologische Agentien bekannt, von denen über 60 % ein zoonotisches Potenzial aufweisen. Als Ergebnis von Expertengesprächen wurde kürzlich berichtet, dass etwa 3 bis 4, meist virale, neu auftretende Infektionskrankheiten ("emerging diseases“) pro Jahr erwartet werden können [15]. Es handelt sich bei diesen Vorgängen aber nicht nur um das Auftauchen vollkommen neuer oder unbeschriebener Spezies, sondern auch um evolutionsbedingte Anpassungen von mikrobiellen Populationen an neue Bedingungen in ihrem Ökosystem [7]. Molekulare Analysen an Umweltchlamydien erbrachten Hinweise, dass die Evolution erste genetische Pathogenitätsmerkmale in dieser Spezies schon vor 700 Mio. Jahren entstehen ließ [14]. Viele Faktoren befeuern den Prozess der Anpassung, unter anderem auch alle Strategien, mit denen der Mensch seit Jahrtausenden versucht, Lebensmittel sicher und haltbar zu machen. Als die treibenden Kräfte des Auftretens neuer Krankheitserreger werden in der Gegenwart vor allem das sich ändernde Weltklima, die globalen Warenströme und die sich verändernden Konsumgewohnheiten genannt. Es steht auch außer Zweifel, dass viele dieser Erreger Tiere als ihr natürliches Reservoir haben werden, d. h. Zoonosen im klassischen Sinne sind [15].

  15. Lehrerbelastungsforschung -- Erweiterung durch ein handlungpsychologisches Belastungskonzept (Research on Teacher's Ability To Cope with Stress -- A Broadening of the Approach by Including a Psychology of Action-Concept of Stress).

    ERIC Educational Resources Information Center

    Krause, Andreas

    2003-01-01

    Reveals that most research on teacher stress relies on personal accounts. Presents a psychology of action-concept of stress and that has been transferred to teacher's instructional activities. Argues that this psychology of action concept of stress helps develop an understanding of teachers' work and what may lead to psychological stress. (CAJ)

  16. The reprint of a chapter of Nicolaus Copernicus' principal book by Heinrich Brucaeus, Rostock 1573 (German Title: Der Nachdruck eines Kapitels des Hauptwerkes von Nicolaus Copernicus durch Heinrich Brucaeus, Rostock 1573)

    NASA Astrophysics Data System (ADS)

    Hamel, Jürgen

    The book "De motu primo libri tres" of the Rostock professor Heinrich Brucaeus (1530-1593), which appeared in 1573, contains an unmodified reprint of a section of Copernicus` principal work, first book, 14th chapter, exercise 3. This reprint, hitherto unnoticed, is of interest for the reception of Copernicus' work. This article reproduces the text and presents some research on Brucaeus, who was Tycho Brahe's teacher in Rostock. His biography and his scientific achievements are outlined.

  17. ANALYSIS OF THE MICROBIOLOGICAL PARTICULATES IN MUNICIPAL DRINKING-WATER BY SCANNING ELECTRON MICROSCOPY/X-RAY ENERGY SPECTROSCOPY (ANALYSE VON BIOLOGISCHEN PARTIKELN IM TRINKWASSER DURCH RASTERELEKTRONEN-MIKROSKOPIE UND ELEKTRONENSTRAHLMIKROANALYSE)

    EPA Science Inventory

    Scanning electron microscopy and X-ray energy spectroscopy (SEM/XES) were used to survey the biological and nonbiological particles in two different municipal drinking-water systems. Microbiological particles could be differentiated from nonbiological by their qualitative element...

  18. orbis (sphaera), circulus, via, iter, orbita -- on the terminological identification of the essential paradigm change in astronomy by Johannes Kepler. (German Title: orbis (sphaera), circulus, via, iter, orbita} -- zur terminologischen Kennzeichnung des wesentlichsten Paradigmawechsels in der Astronomie durch Johannes Kepler)

    NASA Astrophysics Data System (ADS)

    Krafft, Fritz

    2011-08-01

    The use of modern terminology hinders to understand historical astronomical texts and often misleads the reader. Therefore, this study tries to reconstruct the ideas of the way the planets seem to move against the sphere of fixed stars in a non-teleological manner, that means in the original view and with original terms. The study proceeds historically and explains: (1) Aristotle's system of homocentric spheres being hollow spheres of ether turning equally round the earth in the centre of the world, a number of which makes the apparatus of the movement of a planet which produces its apparently unequal motion. (2) Ptolemy's reductionistic system of geometric circles (eccentric deferents, epicycles etc.), which are indeed great circles on non-concentric hollow spheres, whereupon they turn around equally. The space which they take up in all is surrounded by an inner and an outer concentric spherical surface and makes the sphere of the planet. (3) John's of Sacrobosco transferring of the geometric astronomy to the Latin of Middle Ages and the commentators' precision of the Greek-Latin terms. (4) The tradition of the "Theorica planetarum" which makes this geometry physics by allotting every partial moving to a partial material hollow sphere (with spherical surfaces of different centricity) or full sphere of an epicycle (orbes particulares or partialis), a number of which makes the entire sphere of each planet (orbis totalis or totus). - Copernicus also stood within this tradition, except that his entire spheres differ from the earlier ones in size or thickness (because he eliminated the partly very big synodic epicycles and allocated their effect as a mere parallactic one to the yearly moving of the earth) and in the great intervening spaces between each other (a result of measuring the true distances of the planets on the basis of these parallactic effects). (5) Tycho Brahe's refutation of the unchangingness and unpermeableness and therefore solidity of all etherial spheres, what had been the fundamental condition for creating the indirect ways of the planets in all astronomical systems with partial or entire spheres engaging one another. It was particularly Kepler who recognizes that as a result celestial physics requires a complete change. (6) Kepler's replacement of celestial physics. He did not think any more that the apparent (unequal) way of a planet indirectly results from the combination of several equal movements of etherial partial and entire spheres. His planets move their true and real way caused directly by the joint effect of two corporal forces moving the planets both around the sun and to and from it, which latter makes the planet's speed indeed naturally unequal. For this "real way" he coins in late 1604 the specific term "orbita" (the modern "orbit", the German "Bahn". This term then little by little replaced the former non-specific, general description of the apparent or real way (as "via, iter, ambitus, circulus, circuitus" etc.), and Kepler used it increasingly from its introduction (initially frequently joined to a describing definition of this "way") up to the exclusive use in the fifth book of the "Epitome", after this "orbita" had changed its shape from a perfect eccentric circle to an oval and finally an elliptic form. This way Kepler marks the paradigm change of astronomy caused by himself also terminologically.

  19. The Shadow of a Gnomon Along a Year: Routine Observations and Teaching of Apparent Motion of the Sun and the Four Seasons. (Spanish Title: La Sombra de un Gnomon lo Largo de un Año: Observaciones de Rutina y la Enseñanza del Movimiento Aparente del Sol y Las Cuatro Estaciones.) A Sombra de um Gnômon ao Longo de um Ano: Observações Rotineiras e o Ensino do Movimento Aparente do Sol E das Quatro Estações

    NASA Astrophysics Data System (ADS)

    Trogello, Anderson Giovani; Danhoni Neves, Marcos Cesar; de Carvalho Rutz da Silva, Sani

    2013-12-01

    , al solsticio de junio, al equinoccio de septiembre y al solsticio de diciembre. Además, se dictaron clases teóricas en la sala de aula. Estos métodos buscaron construir conceptos en torno al movimiento aparente del Sol y la sucesión de las estaciones. Teniendo en cuenta los resultados de las actividades se aplicó una evaluación cuyos datos demuestran la existencia de un aprendizaje deseado por los estudiantes en cuanto a: el reconocimiento de los puntos cardinales, la descripción del movimiento solar aparente y la aparición de las estaciones y su alternancia a partir de observaciones astronómicas visuales sin instrumentos. Muitas concepções alternativas são reconhecidas entre os diversos grupos de estudantes, em especial nos da educação básica. Dentre elas, o movimento aparente do Sol, por mais quotidiano que seja, proporciona variadas interpretações. Deste modo, observar e registrar o movimento dos astros na abóboda celeste é uma tarefa necessária ao ensino de Astronomia. O trabalho que ora se apresenta propõe a apresentação dos resultados da observação do movimento aparente do Sol por intermédio da marcação da sombra de um gnômon vertical por alunos de uma turma do sexto ano do ensino fundamental de uma escola do campo do Paraná. O projeto em si ocorreu em quatro etapas, em datas próximas do equinócio de março, do solstício de junho, do equinócio de setembro e do solstício de dezembro. Além disso, foram desenvolvidas aulas teóricas em sala de aula. Tais métodos buscaram construir conceitos em torno da movimentação aparente do Sol e da alternância das estações do ano. Diante dos resultados provenientes das atividades desenvolvidas foi aplicada uma avaliação e os dados demonstraram um aprendizado desejado dos alunos quanto: ao reconhecimento dos pontos cardeais; à descrição do movimento solar aparente e a ocorrência das estações do ano e sua alternância a partir de observações astronômicas a olho nu.

  20. 50 CFR 648.53 - Target total allowable catch, DAS allocations, and individual fishing quotas.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... shall be made electronically via the Federal web portal, www.pay.gov, or other Internet sites as... payment Web site and the paper bill. Payment options shall include payment via a credit card, as...

  1. Consideracoes Extemporaneas acerca das Metodologias Qualitativas (Extemporaneous Considerations about Qualitative Methodology).

    ERIC Educational Resources Information Center

    Pucci, Bruno

    2000-01-01

    Considers the differences between quantitative and qualitative research. Cites some essays by Adorno when he was living in New York which led to the conclusion that empirical data has much to say and discusses the theoretical-methodological contributions in a recent master's thesis in education. (BT)

  2. Kepler, Galilei, the telescope and the consequences. (German Title: Kepler, Galilei, das Fernrohr und die Folgen)

    NASA Astrophysics Data System (ADS)

    Hamel, Jürgen

    In the beginning Copernicus' system of the world did not have empirical confirmation. In this situation, Kepler's research, as well as the astronomical observations with the telescope, invented in 1608, played a decisive role. Under the assumption of the central position of the Sun, Kepler discovered the elliptical orbital motion of the planets as a base of the computation of noticeably improved ephemerides. The first telescopic observations - Jupiter's moons, phases of Venus, sunspots, surface features of the moon -, gave important arguments for Copernicus' system. Galilei was one of the first who used the telescope for astronomical research.

  3. A Data Acquisition System (DAS) for marine and ecological research from aerospace technology

    NASA Technical Reports Server (NTRS)

    Johnson, R. A.

    1972-01-01

    The efforts of researchers at Mississippi State University to utilize space-age technology in the development of a self-contained, portable data acquisition system for use in marine and ecological research are presented. The compact, lightweight data acquisition system is capable of recording 14 variables in its present configuration and is suitable for use in either a boat, pickup truck, or light aircraft. This system will provide the acquisition of reliable data on the structure of the environment and the effect of man-made and natural activities on the observed phenomenon. Utilizing both self-contained analog recording and a telemetry transmitter for real-time digital readout and recording, the prototype system has undergone extensive testing.

  4. O Universo das Sociedades Numa Perspectiva Relativa: Exercícios de Etnoastronomia

    NASA Astrophysics Data System (ADS)

    Fares, Érika Akel; Pessoa Martins, Karla; Maciel Araujo, Lidiane; Sauma Filho, Michel

    2004-12-01

    This work developed at the Planetarium of Pará employing workshops designed for visitor schools (public, private, specials groups), promotes the popularization of the Ethnoastronomy with the aim of diffusing values based on a cultural diversity tolerance and the need of harmonic interplay between people and environment. Using stories and debates, the relationship between humans and the Cosmos is traced from antiquity until today, with the help of slides as a didactic resource. Thus, many conceptions about the origin of the Universe are shown; as well as some constellations created along the History, ending with the present scientific manner of know and explain the World. We then demonstrate the links between space, time and culture with the Cosmos vision. The need to think the World within a plural context to create respect for other different persons is emphasized. Este trabalho, desenvolvido no Planetário do Pará através de oficinas com escolas visitantes (públicas, privadas e grupos especiais), promove a popularização da Etnoastronomia, com o objetivo de difundir valores pautados na tolerância à diversidade cultural e na necessidade da convivência harmônica entre o ser humano e o meio ambiente. Através da contação de histórias e promoção de debate, é tratada a relação dos humanos com o céu desde a antiguidade até os dias atuais, tendo como apoio didático o uso de slides. Assim, são mostradas diversas concepções de origem do Universo; algumas constelações criadas no decorrer da História; e a atual forma científica de conhecer e explicar o mundo. Demonstrando-se, então, a interligação entre espaço, tempo e cultura com a visão do Cosmo. Enfatiza-se a necessidade de se pensar o mundo numa perspectiva relativa ou plural, de forma a propiciar o respeito ao ser diferente.

  5. A Integracao de Ensino das Ciencias da Saude (An Integrated Medical Education Program [in Brazil]).

    ERIC Educational Resources Information Center

    Pourchet-Campos, M. A.; Guimaraes Junior, Paulino

    At the Sixth Annual Reunion of the Brazilian Association of Medical Schools (VI Reuniao Anual da Associacao Brasileira de Escolas Medicas) leaders in the Brazilian medical profession proposed an integrated educational program for training students in the fields of medicine and public health. Under Brazil's present system of education, all…

  6. Bring Back "Das Kapital" Punishment! Credit Crunch and the Fall of the "Knowledge Economy"

    ERIC Educational Resources Information Center

    Stronach, Ian; Clarke, John

    2010-01-01

    This article contrasts the collapse of the twin political certainties of the 20th century--"scientific socialism" (1989) and "scientific capitalism" (2008). Such a collapse restores Uncertainty to her throne, and brings back the need to radically rethink political possibilities for the future. (Contains 1 note.)

  7. Auswirkungen einer Pipeline-Verlegung auf das marine Benthos im Tidebecken von Baltrum-Langeoog

    NASA Astrophysics Data System (ADS)

    van Bernem, K. H.

    1999-12-01

    In order to investigate possible effects on benthic communities resulting from the landfall of the “EU-ROPIPE” gas pipeline in areas of the Wadden Sea National Park of Lower Saxony the following seasonal surveys were carried out by the GKSS-Research-Centre during 1993 1997: a) Assessment of species number and abundance of subtidal and intertidal macrofauna, b) Intertidal documentation of demersal fish and decapod crab stocks, c) Intertidal assessment of species composition and abundance of microalgae. Sublittoral sampling was mainly carried out by bottom-grabs and box-dredges at about 120 locations recorded by GPS. Sediment cores of intertidal benthic communities at 6 locations were processed for macrofauna and microalgae. Species numbers and abundances of sublittoral benthic macrofauna decreased during 1994 as well in those areas directly affected as well as in areas 500 to 1000m removed from the construction activities. Most notably, the relatively high species richness of a hard-bottom community, rare in Wadden Sea areas, was strongly disturbed. During the same period the spatial distribution and abundance of intertidal filter feeders decreased as well as the abundance of vagile predating polychaetes and amphipods at locations situated near low tide level. A local stock of the low dispersive Goby ( Pomatoschistus microps) was nearly totally destroyed. Decreases in the abundances of juvenile Plaice ( Pleuronectes platessa) and decapod crabs ( Crangon crangon, Carcinus maenas) could only be shown during July/October 1994 in those areas of working activities which were directly connected to the tidal migration paths of these species. During 1994/95 numbers and abundances of diatom species prefering fine grained sediments with a high amount of organic material increased significantly. A recovery started immediately after conclusion of the refilling measures in 1995. A complete documentation of the community-resilience, however, was masked by fluctuations following the ice-winter in 1995/96.

  8. 50 CFR 648.10 - VMS and DAS requirements for vessel owners/operators.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Point Light 43°50.2′ 69°30.4′ 8. A point west of Halfway Rock 43°38.0′ 70°05.0′ 9. A point east of Cape... Ledge Light 42°16.2′ 70°45.6′ 16. Farnham Rock Lighted Bell Buoy 42°05.6′ 70°36.5′ 17. Cape Cod Canal... on either a common pool or sector trip must declare the following information via VMS or IVR,...

  9. Kindern das Wort Geben ein interkulturell-kreativer Arbeitsansatz, aufgezeigt an der Arbeit mit tibetischen Migrantenkindern

    NASA Astrophysics Data System (ADS)

    Rabkin, Gabriele

    2001-03-01

    Promotion of creativity in the cause of peace and international understanding is a fundamental part of the UNESCO programme to build a culture of peace. A central aspect of this undertaking consists in encouraging children to express themselves freely on this subject in writing and art. An approach has been developed to stimulate children's creativity and to create a link between creative expression and education for intercultural understanding. This article is divided into two parts. The first explains the pedagogical and psychological concepts behind this approach. The second describes a project in which these concepts were applied. It focuses on a minority dispersed over many parts of the world, namely children of Tibetan families. The description is accompanied by commentaries of the Fourteenth Dalai Lama, arising from a personal audience granted to the author in 1999.

  10. NSP-North Dakota delays $2 million substation project by using DAS

    SciTech Connect

    Wolfe, D.

    1994-12-31

    This case study will discuss a substation capacity problem recently faced by Northern States Power (NSP) of Grand Forks, ND, and how the problem was resolved. In the Late 1980`s, it became apparent that some sort of substation capacity relief would be required for the electric distribution system of Grand Forks. After studying alternatives, the chosen solution was to implement a distribution automation system allowing for load transfer between substations. In the following, we will discuss: (1) the problem faced by NSP; (2) the implementation of the DA system; (3) advantages and disadvantages of the chosen solution; (4) the results of the system; (5) future expansion plans; and (6) some practical advice.