Mutations in the alanine�glyoxylate amino transferase gene (AGXT) are responsible for primary hyperoxaluria type I, a rare disease characterized by excessive hepatic oxalate production that leads to renal failure. We generated a null mutant mouse by targeted mutagenesis of the homologous gene, Agxt, in embryonic stem cells. Mutant mice developed ...
PubMed Central
Primary hyperoxaluria type 1 is a rare autosomal recessive disease caused by mutations in the alanine glyoxylate aminotransferase gene (AGXT). We have previously shown that P11L and I340M polymorphisms together with I244T mutation (AGXT-LTM) represent a conformational disease that could be amenable to pharmacological intervention. Thus, the study of the ...
Oxalobacter colonization of rat intestine was previously shown to promote enteric oxalate secretion and elimination, leading to significant reductions in urinary oxalate excretion (Hatch et al. Kidney Int 69: 691-698, 2006). The main goal of the present study, using a mouse model of primary hyperoxaluria type 1 (PH1), was to test the hypothesis that colonization of the mouse gut by Oxalobacter ...
PubMed
Gen 2 snakebot � Publication Size. Gen 2 snake. Gen 1 and Gen 2 snakebots � Publication Size. Gen 1 and 2 snakes intertwined. ...
NASA Website
The Pro11Leu substitution in the AGXT gene, which causes primary hyperoxaluria type 1, is found with high frequency in some human populations (e.g., 5-20% in Caucasians). It has been suggested that this detrimental mutation could have been positively selected in populations with a meat-rich diet. In order to test this hypothesis, we investigated the occurrence of Pro11Leu in ...
... Abstract : The purpose of the Next Generation (NextGen) Air Transportation System Avionics Roadmap (ARM) is to translate proposed NextGen ...
DTIC Science & Technology
... 10201. Telephone Area Code, C-GEN-10202. Telephone Country Code, C-GEN-10203. ... 10205. Telephone City Code, C-GEN-10206. ...
Center for Drug Evaluation (CDER)
FAA Plans and Requirements for NextGen. Federal Aviation. Administration. NASA. November 18, 2008. 2. Focusing Research Activities for NextGen. Recapture ...
This dataset holds the observations recorded during the GEO Biodiversity Day 'Birdrace-ARKONAuten-R�gen' in Bergen/R�gen...
NBII National Biological Information Infrastructure
SEQ-GEN is a user-interactive computer program used to plan and generate a sequence of commands for spacecraft. Desired activities are specified by the user of SEQ-GEN; SEQ-GEN in turn expands these activities, deriving the spacecraft commands necessary t...
National Technical Information Service (NTIS)
... OriGen Cryostore Freezing Bags. Applicant: OriGen BioMedical, Austin, TX 78758. 510(k) number: BK030036. Product: OriGen Cryostore Freezing Bags. Date: 10/1/2003 ...
Center for Biologics Evaluation and Research (CBER)
