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Sample records for generalized stiffness coefficients

  1. Experimental and theoretical rotordynamic stiffness coefficients for a three-stage brush seal

    NASA Astrophysics Data System (ADS)

    Pugachev, A. O.; Deckner, M.

    2012-08-01

    Experimental and theoretical results are presented for a multistage brush seal. Experimental stiffness is obtained from integrating circumferential pressure distribution measured in seal cavities. A CFD analysis is used to predict seal performance. Bristle packs are modeled by the porous medium approach. Leakage is predicted well by the CFD method. Theoretical stiffness coefficients are in reasonable agreement with the measurements. Experimental results are also compared with a three-teeth-on-stator labyrinth seal. The multistage brush seal gives about 60% leakage reduction over the labyrinth seal. Rotordynamic stiffness coefficients are also improved: the brush seal has positive direct stiffness and smaller cross-coupled stiffness.

  2. Stiffness and Damping Coefficient Estimation of Compliant Surface Gas Bearings for Oil-Free Turbomachinery

    NASA Technical Reports Server (NTRS)

    Della-Corte, Christopher

    2012-01-01

    Foil gas bearings are a key technology in many commercial and emerging oilfree turbomachinery systems. These bearings are nonlinear and have been difficult to analytically model in terms of performance characteristics such as load capacity, power loss, stiffness, and damping. Previous investigations led to an empirically derived method to estimate load capacity. This method has been a valuable tool in system development. The current work extends this tool concept to include rules for stiffness and damping coefficient estimation. It is expected that these rules will further accelerate the development and deployment of advanced oil-free machines operating on foil gas bearings.

  3. Stiffness and Damping Coefficient Estimation of Compliant Surface Gas Bearings for Oil-Free Turbomachinery

    NASA Technical Reports Server (NTRS)

    DellaCorte, Christopher

    2010-01-01

    Foil gas bearings are a key technology in many commercial and emerging Oil-Free turbomachinery systems. These bearings are non-linear and have been difficult to analytically model in terms of performance characteristics such as load capacity, power loss, stiffness and damping. Previous investigations led to an empirically derived method, a rule-of-thumb, to estimate load capacity. This method has been a valuable tool in system development. The current paper extends this tool concept to include rules for stiffness and damping coefficient estimation. It is expected that these rules will further accelerate the development and deployment of advanced Oil-Free machines operating on foil gas bearings

  4. Determination of Nonlinear Stiffness Coefficients for Finite Element Models with Application to the Random Vibration Problem

    NASA Technical Reports Server (NTRS)

    Muravyov, Alexander A.

    1999-01-01

    In this paper, a method for obtaining nonlinear stiffness coefficients in modal coordinates for geometrically nonlinear finite-element models is developed. The method requires application of a finite-element program with a geometrically non- linear static capability. The MSC/NASTRAN code is employed for this purpose. The equations of motion of a MDOF system are formulated in modal coordinates. A set of linear eigenvectors is used to approximate the solution of the nonlinear problem. The random vibration problem of the MDOF nonlinear system is then considered. The solutions obtained by application of two different versions of a stochastic linearization technique are compared with linear and exact (analytical) solutions in terms of root-mean-square (RMS) displacements and strains for a beam structure.

  5. Planar lattices with tailorable coefficient of thermal expansion and high stiffness based on dual-material triangle unit

    NASA Astrophysics Data System (ADS)

    Wei, Kai; Chen, Haosen; Pei, Yongmao; Fang, Daining

    2016-01-01

    The unexpected thermal distortions and failures in engineering raise the big concern about thermal expansion controlling. Thus, design of tailorable coefficient of thermal expansion (CTE) is urgently needed for the materials used in large temperature variation circumstance. Here, inspired by multi-fold rotational symmetry in crystallography, we have devised six kinds of periodic planar lattices, which incorporate tailorable CTE and high specific biaxial stiffness. Fabrication process, which overcame shortcomings of welding or adhesion connection, was developed for the dual-material planar lattices. The analytical predictions agreed well with the CTE measurements. It is shown that the planar lattices fabricated from positive CTE constituents, can give large positive, near zero and even negative CTEs. Furthermore, a generalized stationary node method was proposed for aperiodic lattices and even arbitrary structures with desirable thermal expansion. As an example, aperiodic quasicrystal lattices were designed and exhibited zero thermal expansion property. The proposed method for the lattices of lightweight, robust stiffness, strength and tailorable thermal expansion is useful in the engineering applications.

  6. Optimization of the contact damping and stiffness coefficients to minimize human body vibration.

    PubMed

    Amirouche, F M; Xie, M; Patwardhan, A

    1994-11-01

    In this paper, a lumped mass human model is used to minimize the energy absorption at the feet/hip level when the body is subjected to vertical vibration. The contact forces are assumed unknown. By coupling the dynamic response of the body with certain objective criteria, the optimum damping and stiffness coefficients of shoes/chairs are sought. The optimization technique is based on the quasi-Newton and finite-difference gradient method and is used to seek optimum coefficients of the contact forces in the solution of the body's response in the frequency domain. The criteria of acceleration, displacement and internal forces response area swept for a range of 0-15 Hz form the basis of our simulation study. In the seated/standing postures it is found that for each criteria the frequency response shifts the peak of resonance of each body segment response from 4.5/3.67 Hz to 2.5/2.255 Hz. In addition, the total energy reduces drastically when the contact conditions are optimum. The method presented in this paper is useful in modeling the medium of contacts and especially in controlling the effects of human body vibration. PMID:7869717

  7. General dissipative coefficient in strong anisotropic inflation

    NASA Astrophysics Data System (ADS)

    Sharif, M.; Saleem, Rabia

    2015-12-01

    In this paper, we analyze the effects of generalized dissipative coefficient on the dynamics of warm intermediate and logamediate inflationary universe models during strong dissipative regime. We explore these models within the framework of locally rotationally symmetric Bianchi type I universe. In both cases, we evaluate inflaton, effective scalar potential, dissipative coefficient, slow-roll parameters, scalar and tensor power spectra, scalar spectral index and tensor-scalar ratio under slow-roll approximation. The inflationary model as well as perturbed parameters are constrained using recent data. We conclude that intermediate anisotropic inflationary universe model with generalized dissipative coefficient remains compatible with WMAP9, Planck and BICEP2 data while n=1 (arbitrary integer) is the only consistent case during logamediate era. Also, both of these models interpolate between weak and strong regimes.

  8. Non-monotonic dependence of the friction coefficient on heterogeneous stiffness

    PubMed Central

    Giacco, F.; Ciamarra, M. Pica; Saggese, L.; de Arcangelis, L.; Lippiello, E.

    2014-01-01

    The complexity of the frictional dynamics at the microscopic scale makes difficult to identify all of its controlling parameters. Indeed, experiments on sheared elastic bodies have shown that the static friction coefficient depends on loading conditions, the real area of contact along the interfaces and the confining pressure. Here we show, by means of numerical simulations of a 2D Burridge-Knopoff model with a simple local friction law, that the macroscopic friction coefficient depends non-monotonically on the bulk elasticity of the system. This occurs because elastic constants control the geometrical features of the rupture fronts during the stick-slip dynamics, leading to four different ordering regimes characterized by different orientations of the rupture fronts with respect to the external shear direction. We rationalize these results by means of an energetic balance argument. PMID:25345800

  9. Non-monotonic dependence of the friction coefficient on heterogeneous stiffness.

    PubMed

    Giacco, F; Ciamarra, M Pica; Saggese, L; de Arcangelis, L; Lippiello, E

    2014-01-01

    The complexity of the frictional dynamics at the microscopic scale makes difficult to identify all of its controlling parameters. Indeed, experiments on sheared elastic bodies have shown that the static friction coefficient depends on loading conditions, the real area of contact along the interfaces and the confining pressure. Here we show, by means of numerical simulations of a 2D Burridge-Knopoff model with a simple local friction law, that the macroscopic friction coefficient depends non-monotonically on the bulk elasticity of the system. This occurs because elastic constants control the geometrical features of the rupture fronts during the stick-slip dynamics, leading to four different ordering regimes characterized by different orientations of the rupture fronts with respect to the external shear direction. We rationalize these results by means of an energetic balance argument. PMID:25345800

  10. Non-monotonic dependence of the friction coefficient on heterogeneous stiffness

    E-print Network

    Ferdinando Giacco; Luigi Saggese; Lucilla de Arcangelis; Massimo Pica Ciamarra; Eugenio Lippiello

    2015-11-30

    The complexity of the frictional dynamics at the microscopic scale makes difficult to identify all of its controlling parameters. Indeed, experiments on sheared elastic bodies have shown that the static friction coefficient depends on loading conditions, the real area of contact along the interfaces and the confining pressure. Here we show, by means of numerical simulations of a 2D Burridge-Knopoff model with a simple local friction law, that the macroscopic friction coefficient depends non-monotonically on the bulk elasticity of the system. This occurs because elastic constants control the geometrical features of the rupture fronts during the stick-slip dynamics, leading to four different ordering regimes characterized by different orientations of the rupture fronts with respect to the external shear direction. We rationalize these results by means of an energetic balance argument.

  11. A rotor unbalance response based approach to the identification of the closed-loop stiffness and damping coefficients of active magnetic bearings

    NASA Astrophysics Data System (ADS)

    Zhou, Jin; Di, Long; Cheng, Changli; Xu, Yuanping; Lin, Zongli

    2016-01-01

    The stiffness and damping coefficients of active magnetic bearings (AMBs) have direct influence on the dynamic response of a rotor bearing system, including the bending critical speeds, modes of vibrations and stability. Rotor unbalance response is informative in the identification of these bearing support parameters. In this paper, we propose a method for identifying closed-loop AMB stiffness and damping coefficients based on the rotor unbalance response. We will use a flexible rotor-AMB test rig to help describe the proposed method as well as to validate the identification results. First, based on a rigid body model of the rotor, a formula is derived that computes the nominal values of the bearing stiffness and damping coefficients at a given rotating speed from the experimentally measured rotor unbalance response at the given speed. Then, based on a finite element model of the rotor, an error response surface is constructed for each parameter to estimate the identification errors induced by the rotor flexibility. The final identified values of the stiffness and damping coefficients equal the sums of the nominal values initially computed from the unbalance response and the identification errors determined by the error response surfaces. The proposed identification method is carried out on the rotor-AMB test rig. In order to validate the identification results, the identified values of the closed-loop AMB stiffness and damping coefficients are combined with the finite element model of the rotor to form a full model of the rotor-AMB test rig, from which the model unbalance responses at various rotating speeds are determined through simulation and compared with the experimental measurements. The close agreements between the simulation results and the measurements validate the proposed identification method.

  12. Implicit, semi-analytical solution of the generalized Riemann problem for stiff hyperbolic balance laws

    NASA Astrophysics Data System (ADS)

    Toro, Eleuterio F.; Montecinos, Gino I.

    2015-12-01

    We present a semi-analytical, implicit solution to the generalized Riemann problem (GRP) for non-linear systems of hyperbolic balance laws with stiff source terms. The solution method is based on an implicit, time Taylor series expansion and the Cauchy-Kowalewskaya procedure, along with the solution of a sequence of classical Riemann problems. Our new GRP solver is then used to construct locally implicit ADER methods of arbitrary accuracy in space and time for solving the general initial-boundary value problem for non-linear systems of hyperbolic balance laws with stiff source terms. Analysis of the method for model problems is carried out and empirical convergence rate studies for suitable tests problems are performed, confirming the theoretically expected high order of accuracy.

  13. LOGARITHMIC COEFFICIENTS AND GENERALIZED MULTIFRACTALITY OF WHOLE-PLANE SLE

    E-print Network

    LOGARITHMIC COEFFICIENTS AND GENERALIZED MULTIFRACTALITY OF WHOLE-PLANE SLE BERTRAND DUPLANTIER(1 an instance of the whole-plane SLE conformal map from the unit disk D to the slit plane, the derivative on the SLE parameter (0, ). We generalize this property to the mixed moments, E |f (z)|p |f(z)|q , along

  14. Generalized transport coefficients for inelastic Maxwell mixtures under shear flow

    NASA Astrophysics Data System (ADS)

    Garzó, Vicente; Trizac, Emmanuel

    2015-11-01

    The Boltzmann equation framework for inelastic Maxwell models is considered to determine the transport coefficients associated with the mass, momentum, and heat fluxes of a granular binary mixture in spatially inhomogeneous states close to the simple shear flow. The Boltzmann equation is solved by means of a Chapman-Enskog-type expansion around the (local) shear flow distributions fr(0 ) for each species that retain all the hydrodynamic orders in the shear rate. Due to the anisotropy induced by the shear flow, tensorial quantities are required to describe the transport processes instead of the conventional scalar coefficients. These tensors are given in terms of the solutions of a set of coupled equations, which can be analytically solved as functions of the shear rate a , the coefficients of restitution ?r s, and the parameters of the mixture (masses, diameters, and composition). Since the reference distribution functions fr(0 ) apply for arbitrary values of the shear rate and are not restricted to weak dissipation, the corresponding generalized coefficients turn out to be nonlinear functions of both a and ?r s. The dependence of the relevant elements of the three diffusion tensors on both the shear rate and dissipation is illustrated in the tracer limit case, the results showing that the deviation of the generalized transport coefficients from their forms for vanishing shear rates is in general significant. A comparison with the previous results obtained analytically for inelastic hard spheres by using Grad's moment method is carried out, showing a good agreement over a wide range of values for the coefficients of restitution. Finally, as an application of the theoretical expressions derived here for the transport coefficients, thermal diffusion segregation of an intruder immersed in a granular gas is also studied.

  15. Stability criterion for self-similar solutions with a scalar field and those with a stiff fluid in general relativity

    E-print Network

    Harada, T; Harada, Tomohiro; Maeda, Hideki

    2004-01-01

    A stability criterion is derived in general relativity for self-similar solutions with a scalar field and those with a stiff fluid, which is a perfect fluid with the equation of state $P=\\rho$. A wide class of self-similar solutions turn out to be unstable against kink mode perturbation. According to the criterion, the Evans-Coleman stiff-fluid solution is unstable and cannot be a critical solution for the spherical collapse of a stiff fluid if we allow sufficiently small discontinuity in the density gradient field in the initial data sets. The self-similar scalar-field solution, which was recently found numerically by Brady {\\it et al.} (2002), is also unstable. Both the flat Friedmann universe with a scalar field and that with a stiff fluid suffer from kink instability at the particle horizon scale.

  16. Generalized drag coefficient applicable for all flow regimes

    SciTech Connect

    Meyer, B.R.

    1986-05-26

    A generalized drag coefficient correlation for particulate settling in power-law-type fluids is applicable for all flow regimes from Stokes' (laminar) to Newton's flow (turbulence). The major advantage of this correlation for hydrocarbon reservoirs is that it correctly asymptotes to a modified Stokes' law (viscous effects) at low Reynolds value (Re) numbers and to the turbulent drag coefficient C/sub D/ approx. = 0.44 at large values of Re (inertia dominance). The use of Stokes' law can greatly underestimate the drag coefficient and grossly overestimate the terminal settling velocity at large Re. In many respects, this article is a review and extension of drag coefficient correlations used in hydraulic fracturing on particulate settling in Newtonian and non-Newtonian fluids. Since most non-Newtonian correlations are for creeping flow (Re' < 0.1), the major emphasis will be to extend these correlations to Newton's flow. A comparison with experimental data and empirical correlations of other investigators is included to verify the validity and applicability of the extended correlation.

  17. Second virial coefficient of a generalized Lennard-Jones potential.

    PubMed

    González-Calderón, Alfredo; Rocha-Ichante, Adrián

    2015-01-21

    We present an exact analytical solution for the second virial coefficient of a generalized Lennard-Jones type of pair potential model. The potential can be reduced to the Lennard-Jones, hard-sphere, and sticky hard-sphere models by tuning the potential parameters corresponding to the width and depth of the well. Thus, the second virial solution can also regain the aforementioned cases. Moreover, the obtained expression strongly resembles the one corresponding to the Kihara potential. In fact, the Fk functions are the same. Furthermore, for these functions, the complete expansions at low and high temperature are given. Additionally, we propose an alternative stickiness parameter based on the obtained second virial coefficient. PMID:25612707

  18. Aerodynamic coefficients in generalized unsteady thin airfoil theory

    NASA Technical Reports Server (NTRS)

    Williams, M. H.

    1980-01-01

    Two cases are considered: (1) rigid body motion of an airfoil-flap combination consisting of vertical translation of given amplitude, rotation of given amplitude about a specified axis, and rotation of given amplitude of the control surface alone about its hinge; the upwash for this problem is defined mathematically; and (2) sinusoidal gust of given amplitude and wave number, for which the upwash is defined mathematically. Simple universal formulas are presented for the most important aerodynamic coefficients in unsteady thin airfoil theory. The lift and moment induced by a generalized gust are evaluated explicitly in terms of the gust wavelength. Similarly, in the control surface problem, the lift, moment, and hinge moments are given as explicit algebraic functions of hinge location. These results can be used together with any of the standard numerical inversion routines for the elementary loads (pitch and heave).

  19. Generalized Stability of Kronecker Coefficients John R. Stembridge

    E-print Network

    Stembridge, John

    by a partition of m. Given a triple of partitions of m, say , , , the associated Kronecker coefficient is g (largest) parts in a triple of partitions, the Kronecker coefficient stabilizes. That is, the multiplicity of partitions such that the Kronecker coefficient g() is positive. What we study in this paper

  20. Generalized semiparametric varying-coefficient models for longitudinal data

    NASA Astrophysics Data System (ADS)

    Qi, Li

    In this dissertation, we investigate the generalized semiparametric varying-coefficient models for longitudinal data that can flexibly model three types of covariate effects: time-constant effects, time-varying effects, and covariate-varying effects, i.e., the covariate effects that depend on other possibly time-dependent exposure variables. First, we consider the model that assumes the time-varying effects are unspecified functions of time while the covariate-varying effects are parametric functions of an exposure variable specified up to a finite number of unknown parameters. The estimation procedures are developed using multivariate local linear smoothing and generalized weighted least squares estimation techniques. The asymptotic properties of the proposed estimators are established. The simulation studies show that the proposed methods have satisfactory finite sample performance. ACTG 244 clinical trial of HIV infected patients are applied to examine the effects of antiretroviral treatment switching before and after HIV developing the 215-mutation. Our analysis shows benefit of treatment switching before developing the 215-mutation. The proposed methods are also applied to the STEP study with MITT cases showing that they have broad applications in medical research.

  1. Relationships between HDL-C, hs-CRP, with Central Arterial Stiffness in Apparently Healthy People Undergoing a General Health Examination

    PubMed Central

    Fan, Li; Ye, Ping; Yuan, Ying; Lu, XueChun; Wang, Fan; Zeng, Qiang

    2013-01-01

    Background Some cardiovascular risk factors have been confirmed to be positively correlated with arterial stiffness. However, it is unclear whether HDL-C, a well-established anti-risk factor, has an independent association with arterial stiffness. The aim of this study was to evaluate the relationship between HDL-C levels and arterial stiffness and the possible role of high-sensitivity C-reactive protein (hs-CRP) in this potential correlation in apparently healthy adults undergoing a general health examination in China. Materials and Methods This was a cross-sectional survey. In total, 15,302 participants (age range, 18–82 years; mean, 43.88±8.44 years) were recruited during routine health status examinations. A questionnaire was used and we measured the body mass index, systolic and diastolic blood pressure, and fasting glucose, and serum lipid, uric acid, hs-CRP, and serum creatinine levels of each participant. Central arterial stiffness was assessed by carotid–femoral pulse wave velocity (cf-PWV). Results HDL-C levels decreased as cf-PWV increased. Pearson’s correlation analysis revealed that HDL-C levels were associated with cf-PWV (r=?0.18, P<0.001). hs-CRP levels were positively associated with cf-PWV (r=0.13). After adjustment for all confounders, HDL-C was inversely independently associated with all quartiles of cf-PWV. Furthermore, HDL-C was associated with cf-PWV in different quartiles of hs-CRP, and the correlation coefficients (r) gradually decreased with increasing hs-CRP levels (quartiles 1–4). Conclusions HDL-C is inversely independently associated with central arterial stiffness. The anti-inflammatory activity of HDL-C may mediate its relationship with cf-PWV. Further, long-term follow-up studies are needed to evaluate whether high HDL-C levels are protective against central artery stiffening through the anti-inflammatory activity of HDL-C. PMID:24312587

  2. Table for constructing the spin coefficients in general relativity

    SciTech Connect

    Cocke, W. J.

    1989-07-15

    The spin coefficients in spinor calculus in Riemannian space-time are linear functions of the curls of the connecting quantities (the Infeld--Van der Waerden symbols). We show that in the Newman-Penrose formalism the expressions for the spin coefficients are quite manageable, if they are written in terms of the Newman-Penrose tetrad vectors. We present a table of the components of the spin coefficients explicitly in terms of the curls of the individual tetrad vectors.

  3. Generalized approximations of reflection coefficients in orthorhombic media

    NASA Astrophysics Data System (ADS)

    Zhang, Feng; Li, Xiangyang

    2013-10-01

    Reflection coefficients of qP- (quasi-P) and qS- (quasi-S) incident waves in orthorhombic media can be explicitly expressed by means of impedance matrices. In this paper, we extend previous studies and derive the generalized and linearized equations of reflectivity for all four types of waves in the symmetry-axis plane. These approximations have sufficient accuracy over a wide range of angles, therefore they are suitable for characterizing the seismic amplitude responses of unconventional resources. For example, they can be applied to represent the amplitude variation with offset for shale gas or coalbed methane reservoirs with strong anisotropy and complicated symmetry. Reduced equations are then derived in a transverse isotropic medium with a vertical symmetry axis (VTI) or a horizontal axis (HTI) for the anisotropic amplitude inversion. They retain higher accuracy than the corresponding previously published expressions at a strongly anisotropic interface, because they include the second-order terms of anisotropic parameters contrast. Numerical analyses on the inverse problem using different linearized expressions show the practical value of the new derived expressions in the joint inversion of the qPqP- and qPqS-waves for elastic parameters and anisotropic parameters.

  4. Generalized partition functions, interpolating statistics and higher virial coefficients

    E-print Network

    P. F. Borges; H. Boschi-Filho; C. Farina

    1998-11-17

    Starting from determinants at finite temperature obeying an intermediate boundary condition between the periodic (bosonic) and antiperiodic (fermionic) cases, we find results which can be mapped onto the ones obtained from anyons for the second virial coefficient. Using this approach, we calculate the corresponding higher virial coefficients and compare them with the results known in the literature.

  5. Sensitivity of overall vehicle stiffness to local joint stiffness

    NASA Technical Reports Server (NTRS)

    Chon, Choon T.

    1987-01-01

    How overall vehicle stiffness is affected by local joint stiffness is discussed. By using the principle of virtual work and the minimum strain energy theorem, a closed form expression for the sensitivity coefficient was derived. The insensitivity of the vehicle stiffness to a particular joint, when its stiffness exceeds a certain value (or threshold value), was proven mathematically. In order to investigate the sensitivity of the structure to the joint stiffness, a so-called stick model was created, and the modeling technique is briefly described. Some data on joint stiffness of tested vehicles are also presented.

  6. A Generalized Family of Coefficients of Relational Agreement for Numerical Scales.

    ERIC Educational Resources Information Center

    Fagot, Robert F.

    1993-01-01

    A family of coefficients of relational agreement for numerical scales is proposed, generalizing to multiple judges the theory of F. E. Zegers and J. M. F. ten Berge (1985) of association coefficients for two variables, using the premise that choice of coefficient depends on scale type of the variables. (SLD)

  7. General dissipation coefficient in low-temperature warm inflation

    SciTech Connect

    Bastero-Gil, Mar; Berera, Arjun; Rosa, João G.; Ramos, Rudnei O. E-mail: ab@ph.ed.ac.uk E-mail: joao.rosa@ed.ac.uk

    2013-01-01

    In generic particle physics models, the inflaton field is coupled to other bosonic and fermionic fields that acquire large masses during inflation and may decay into light degrees of freedom. This leads to dissipative effects that modify the inflationary dynamics and may generate a nearly-thermal radiation bath, such that inflation occurs in a warm rather than supercooled environment. In this work, we perform a numerical computation and obtain expressions for the associated dissipation coefficient in supersymmetric models, focusing on the regime where the radiation temperature is below the heavy mass threshold. The dissipation coefficient receives contributions from the decay of both on-shell and off-shell degrees of freedom, which are dominant for small and large couplings, respectively, taking into account the light field multiplicities. In particular, we find that the contribution from on-shell decays, although Boltzmann-suppressed, can be much larger than that of virtual modes, which is bounded by the validity of a perturbative analysis. This result opens up new possibilities for realizations of warm inflation in supersymmetric field theories.

  8. Standardized compliance matrixes for general anisotropic materials and a simple measure of anisotropy degree based on shear-extension coupling coefficient

    E-print Network

    Jiamin Zhao; Xiaoxiong Song; Bin Liu

    2015-08-10

    The compliance matrix for a general anisotropic material is usually expressed in an arbitrarily chosen coordinate system, which brings some confusion or inconvenience in identifying independent elastic material constants and comparing elastic properties between different materials. In this paper, a unique stiffest orientation based standardized (STF-OS) compliance matrix is established, and 18 independent elastic material constants are clearly shown. During the searching process for stiffest orientation, it is interesting to find from our theoretical analysis and an example that a material with isotropic tensile stiffness does not definitely possess isotropic elasticity. Therefore the ratio between the maximum and minimum tensile stiffnesses is not a correct measure of anisotropy degree. Alternatively, a simple and correct measure of anisotropy degree based on the maximum shear-extension coupling coefficient in all orientations is proposed.

  9. In-plane, flexural, twisting and thickness-shear coefficients for stiffness and damping of a monolayer filamentary composite, part 1

    NASA Technical Reports Server (NTRS)

    Bert, C. W.; Chang, S.

    1972-01-01

    Elastic and damping analyses resulting in determinations of the various stiffnesses and associated loss tangents for the complete characterization of the elastic and damping behavior of a monofilament composite layer are presented. For the determination of the various stiffnesses, either an elementary mechanics-of-materials formulation or a more rigorous mixed-boundary-value elasticity formulation is used. The solution for the latter formulation is obtained by means of the boundary-point least-square error technique. Kimball-Lovell type damping is assumed for each of the constituent materials. For determining the loss tangents associated with the various stiffnesses, either the viscoelastic correspondence principle or an energy analysis based on the appropriate elastic stress distribution is used.

  10. Pore pressure evolution in deforming granular material: A general formulation and the infinitely stiff approximation

    E-print Network

    Einat, Aharonov

    Pore pressure evolution in deforming granular material: A general formulation and the infinitely of the granular network leads to pore fluid pressure (PP) changes. If the PP rises enough, the fluidfilled the two possible modes of pore fluid pressurization: (1) via rapid fluid flow when fluid drainage is good

  11. Irregular parameter dependence of generalized diffusion coefficients based on large deviation statistical analysis.

    PubMed

    Yoshida, Masaomi; Miyazaki, Syuji; Fujisaka, Hirokazu

    2006-08-01

    The nonperturbative non-Gaussian characteristics of diffusive motion are examined in the framework of the large deviation statistical theory, where simple extended mapping models showing chaotic diffusion are taken as an example. Furthermore, by rigorously solving the large deviation statistical quantities, it is found that the same type of anomalous, complex control parameter dependence as that for the diffusion coefficient reported by Klages and Dorfman is also observed in the large deviation statistical quantities such as the weighted average, the generalized diffusion coefficient, and the generalized power spectrum densities. PMID:17025522

  12. Irregular parameter dependence of generalized diffusion coefficients based on large deviation statistical analysis

    NASA Astrophysics Data System (ADS)

    Yoshida, Masaomi; Miyazaki, Syuji; Fujisaka, Hirokazu

    2006-08-01

    The nonperturbative non-Gaussian characteristics of diffusive motion are examined in the framework of the large deviation statistical theory, where simple extended mapping models showing chaotic diffusion are taken as an example. Furthermore, by rigorously solving the large deviation statistical quantities, it is found that the same type of anomalous, complex control parameter dependence as that for the diffusion coefficient reported by Klages and Dorfman is also observed in the large deviation statistical quantities such as the weighted average, the generalized diffusion coefficient, and the generalized power spectrum densities.

  13. Generalized Caroli formula for the transmission coefficient with lead-lead coupling.

    PubMed

    Li, Huanan; Agarwalla, Bijay Kumar; Wang, Jian-Sheng

    2012-07-01

    We present a generalized transmission coefficient formula for the lead-junction-lead system, in which interaction between the leads has been taken into account. Based on this formula, the Caroli formula could be easily recovered and a transmission coefficient formula for interface problem in the ballistic system can be obtained. The condition of validity for the formula is carefully explored. We mainly focus on heat transport. However, the corresponding electrical transport could be similarly dealt with. Also, an illustrative example is given to clarify the precise meaning of the quantities used in the formula, such as the concept of the reduced interacting matrix in different situations. In addition, an explicit transmission coefficient formula for a general one-dimensional interface setup is obtained based on the derived interface formula. PMID:23005402

  14. Beam shape coefficients of the most general focused Gaussian laser beam for light scattering applications

    NASA Astrophysics Data System (ADS)

    Lock, James A.

    2013-09-01

    The vector wave equation for electromagnetic waves, when subject to a number of constraints corresponding to propagation of a monochromatic beam, reduces to a pair of inhomogeneous differential equations describing the transverse electric and transverse magnetic polarized beam components. These differential equations are solved analytically to obtain the most general focused Gaussian beam to order s4, where s is the beam confinement parameter, and various properties of the most general Gaussian beam are then discussed. The radial fields of the most general Gaussian beam are integrated to obtain the on-axis beam shape coefficients of the generalized Lorenz-Mie theory formalism of light scattering. The beam shape coefficients are then compared with those of the localized Gaussian beam model and the Davis-Barton fifth-order symmetrized beam.

  15. Statistical Properties of Generalized Gini Coefficient with Application to Health Inequality Measurement

    ERIC Educational Resources Information Center

    Lai, Dejian; Huang, Jin; Risser, Jan M.; Kapadia, Asha S.

    2008-01-01

    In this article, we report statistical properties of two classes of generalized Gini coefficients (G1 and G2). The theoretical results were assessed via Monte Carlo simulations. Further, we used G1 and G2 on life expectancy to measure health inequalities among the provinces of China and the states of the United States. For China, the results…

  16. Coefficient of performance and its bounds with the figure of merit for a general refrigerator

    NASA Astrophysics Data System (ADS)

    Long, Rui; Liu, Wei

    2015-02-01

    A general refrigerator model with non-isothermal processes is studied. The coefficient of performance (COP) and its bounds at maximum ? figure of merit are obtained and analyzed. This model accounts for different heat capacities during the heat transfer processes. So, different kinds of refrigerator cycles can be considered. Under the constant heat capacity condition, the upper bound of the COP is the Curzon-Ahlborn (CA) coefficient of performance and is independent of the time durations of the heat exchanging processes. With the maximum ? criterion, in the refrigerator cycles, such as the reversed Brayton refrigerator cycle, the reversed Otto refrigerator cycle and the reversed Atkinson refrigerator cycle, where the heat capacity in the heat absorbing process is not less than that in the heat releasing process, their COPs are bounded by the CA coefficient of performance; otherwise, such as for the reversed Diesel refrigerator cycle, its COP can exceed the CA coefficient of performance. Furthermore, the general refined upper and lower bounds have been proposed.

  17. Arterial Stiffness

    PubMed Central

    Avolio, Alberto

    2013-01-01

    Stiffness of large arteries has been long recognized as a significant determinant of pulse pressure. However, it is only in recent decades, with the accumulation of longitudinal data from large and varied epidemiological studies of morbidity and mortality associated with cardiovascular disease, that it has emerged as an independent predictor of cardiovascular risk. This has generated substantial interest in investigations related to intrinsic causative and associated factors responsible for the alteration of mechanical properties of the arterial wall, with the aim to uncover specific pathways that could be interrogated to prevent or reverse arterial stiffening. Much has been written on the haemodynamic relevance of arterial stiffness in terms of the quantification of pulsatile relationships of blood pressure and flow in conduit arteries. Indeed, much of this early work regarded blood vessels as passive elastic conduits, with the endothelial layer considered as an inactive lining of the lumen and as an interface to flowing blood. However, recent advances in molecular biology and increased technological sophistication for the detection of low concentrations of biochemical compounds have elucidated the highly important regulatory role of the endothelial cell affecting vascular function. These techniques have enabled research into the interaction of the underlying passive mechanical properties of the arterial wall with the active cellular and molecular processes that regulate the local environment of the load-bearing components. This review addresses these emerging concepts. PMID:26587425

  18. A generalized Benford's law for JPEG coefficients and its applications in image forensics

    NASA Astrophysics Data System (ADS)

    Fu, Dongdong; Shi, Yun Q.; Su, Wei

    2007-02-01

    In this paper, a novel statistical model based on Benford's law for the probability distributions of the first digits of the block-DCT and quantized JPEG coefficients is presented. A parametric logarithmic law, i.e., the generalized Benford's law, is formulated. Furthermore, some potential applications of this model in image forensics are discussed in this paper, which include the detection of JPEG compression for images in bitmap format, the estimation of JPEG compression Qfactor for JPEG compressed bitmap image, and the detection of double compressed JPEG image. The results of our extensive experiments demonstrate the effectiveness of the proposed statistical model.

  19. Integrability study on a generalized (2+1)-dimensional variable-coefficient Gardner model with symbolic computation

    SciTech Connect

    Lue Xing; Zhang Haiqiang; Xu Tao; Li He; Tian Bo

    2010-12-15

    Gardner model describes certain nonlinear elastic structures, ion-acoustic waves in plasmas, and shear flows in ocean and atmosphere. In this paper, by virtue of the computerized symbolic computation, the integrability of a generalized (2+1)-dimensional variable-coefficient Gardner model is investigated. Painleve integrability conditions are derived among the coefficient functions, which reduce all the coefficient functions to be proportional only to {gamma}(t), the coefficient of the cubic nonlinear term u{sup 2}u{sub x}. Then, an independent transformation of the variable t transforms the reduced {gamma}(t)-dependent equation into a constant-coefficient integrable one. Painleve test shows that this is the only case when our original generalized (2+1)-dimensional variable-coefficient Gardner model is integrable.

  20. A method for assigning species into groups based on generalized Mahalanobis distance between habitat model coefficients

    USGS Publications Warehouse

    Williams, C.J.; Heglund, P.J.

    2009-01-01

    Habitat association models are commonly developed for individual animal species using generalized linear modeling methods such as logistic regression. We considered the issue of grouping species based on their habitat use so that management decisions can be based on sets of species rather than individual species. This research was motivated by a study of western landbirds in northern Idaho forests. The method we examined was to separately fit models to each species and to use a generalized Mahalanobis distance between coefficient vectors to create a distance matrix among species. Clustering methods were used to group species from the distance matrix, and multidimensional scaling methods were used to visualize the relations among species groups. Methods were also discussed for evaluating the sensitivity of the conclusions because of outliers or influential data points. We illustrate these methods with data from the landbird study conducted in northern Idaho. Simulation results are presented to compare the success of this method to alternative methods using Euclidean distance between coefficient vectors and to methods that do not use habitat association models. These simulations demonstrate that our Mahalanobis-distance- based method was nearly always better than Euclidean-distance-based methods or methods not based on habitat association models. The methods used to develop candidate species groups are easily explained to other scientists and resource managers since they mainly rely on classical multivariate statistical methods. ?? 2008 Springer Science+Business Media, LLC.

  1. Estimation and Inference in Generalized Additive Coefficient Models for Nonlinear Interactions with High-Dimensional Covariates

    PubMed Central

    Shujie, MA; Carroll, Raymond J.; Liang, Hua; Xu, Shizhong

    2015-01-01

    In the low-dimensional case, the generalized additive coefficient model (GACM) proposed by Xue and Yang [Statist. Sinica 16 (2006) 1423–1446] has been demonstrated to be a powerful tool for studying nonlinear interaction effects of variables. In this paper, we propose estimation and inference procedures for the GACM when the dimension of the variables is high. Specifically, we propose a groupwise penalization based procedure to distinguish significant covariates for the “large p small n” setting. The procedure is shown to be consistent for model structure identification. Further, we construct simultaneous confidence bands for the coefficient functions in the selected model based on a refined two-step spline estimator. We also discuss how to choose the tuning parameters. To estimate the standard deviation of the functional estimator, we adopt the smoothed bootstrap method. We conduct simulation experiments to evaluate the numerical performance of the proposed methods and analyze an obesity data set from a genome-wide association study as an illustration. PMID:26412908

  2. General expressions and physical origin of the coupling coefficient of arbitrary tuned coupled electromagnetic resonators

    NASA Astrophysics Data System (ADS)

    Elnaggar, Sameh Y.; Tervo, Richard J.; Mattar, Saba M.

    2015-11-01

    The theory and operation of various devices and systems, such as wireless power transfer via magnetic resonant coupling, magneto-inductive wave devices, magnetic resonance spectroscopy probes, and metamaterials can rely on coupled tuned resonators. The coupling strength is usually expressed in terms of the coupling coefficient ?, which can have electrical ?E and/or magnetic ?M components. In the current article, general expressions of ? are derived. The relation between the complex Poynting equation in its microscopic form and ? is made and discussed in detail. It is shown that ? can be expressed in terms of the interaction energy between the resonators' modes. It thus provides a general form that combines the magnetic and electric components of ?. The expressions make it possible to estimate the frequencies and fields of the coupled modes for arbitrarily oriented and spaced resonators. Thus, enabling the calculation of system specific parameters such as the transfer efficiency of wireless power transfer systems, resonator efficiency for electron spin resonance probes, and dispersion relations of magneto-inductive and stereo-metamaterials structures.

  3. Racah's method for general subalgebra chains: Coupling coefficients of SO(5) in canonical and physical bases

    E-print Network

    M. A. Caprio; K. D. Sviratcheva; A. E. McCoy

    2010-06-15

    It is shown that the method of infinitesimal generators ("Racah's method") can be broadly and systematically formulated as a method applicable to the calculation of reduced coupling coefficients for a generic subalgebra chain G>H, provided the reduced matrix elements of the generators of G and the recoupling coefficients of H are known. The calculation of SO(5)>SO(4) reduced coupling coefficients is considered as an example, and a procedure for transformation of reduced coupling coefficients between canonical and physical subalegebra chains is presented. The problem of calculating coupling coefficients for generic irreps of SO(5), reduced with respect to any of its subalgebra chains, is completely resolved by this approach.

  4. A computer program for two-particle generalized coefficients of fractional parentage

    NASA Astrophysics Data System (ADS)

    Deveikis, A.; Juodagalvis, A.

    2008-10-01

    We present a FORTRAN90 program GCFP for the calculation of the generalized coefficients of fractional parentage (generalized CFPs or GCFP). The approach is based on the observation that the multi-shell CFPs can be expressed in terms of single-shell CFPs, while the latter can be readily calculated employing a simple enumeration scheme of antisymmetric A-particle states and an efficient method of construction of the idempotent matrix eigenvectors. The program provides fast calculation of GCFPs for a given particle number and produces results possessing numerical uncertainties below the desired tolerance. A single j-shell is defined by four quantum numbers, (e,l,j,t). A supplemental C++ program parGCFP allows calculation to be done in batches and/or in parallel. Program summaryProgram title:GCFP, parGCFP Catalogue identifier: AEBI_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEBI_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 17 199 No. of bytes in distributed program, including test data, etc.: 88 658 Distribution format: tar.gz Programming language: FORTRAN 77/90 ( GCFP), C++ ( parGCFP) Computer: Any computer with suitable compilers. The program GCFP requires a FORTRAN 77/90 compiler. The auxiliary program parGCFP requires GNU-C++ compatible compiler, while its parallel version additionally requires MPI-1 standard libraries Operating system: Linux (Ubuntu, Scientific) (all programs), also checked on Windows XP ( GCFP, serial version of parGCFP) RAM: The memory demand depends on the computation and output mode. If this mode is not 4, the program GCFP demands the following amounts of memory on a computer with Linux operating system. It requires around 2 MB of RAM for the A=12 system at E?2. Computation of the A=50 particle system requires around 60 MB of RAM at E=0 and ˜70 MB at E=2 (note, however, that the calculation of this system will take a very long time). If the computation and output mode is set to 4, the memory demands by GCFP are significantly larger. Calculation of GCFPs of A=12 system at E=1 requires 145 MB. The program parGCFP requires additional 2.5 and 4.5 MB of memory for the serial and parallel version, respectively. Classification: 17.18 Nature of problem: The program GCFP generates a list of two-particle coefficients of fractional parentage for several j-shells with isospin. Solution method: The method is based on the observation that multishell coefficients of fractional parentage can be expressed in terms of single-shell CFPs [1]. The latter are calculated using the algorithm [2,3] for a spectral decomposition of an antisymmetrization operator matrix Y. The coefficients of fractional parentage are those eigenvectors of the antisymmetrization operator matrix Y that correspond to unit eigenvalues. A computer code for these coefficients is available [4]. The program GCFP offers computation of two-particle multishell coefficients of fractional parentage. The program parGCFP allows a batch calculation using one input file. Sets of GCFPs are independent and can be calculated in parallel. Restrictions:A<86 when E=0 (due to the memory constraints); small numbers of particles allow significantly higher excitations, though the shell with j?11/2 cannot get full (it is the implementation constraint). Unusual features: Using the program GCFP it is possible to determine allowed particle configurations without the GCFP computation. The GCFPs can be calculated either for all particle configurations at once or for a specified particle configuration. The values of GCFPs can be printed out with a complete specification in either one file or with the parent and daughter configurations printed in separate files. The latter output mode requires additional time and RAM memory. It is possible to restrict the ( J,T) values of the considered particle configurations. (Here J is the total angular momentum and

  5. Rotordynamic coefficient test results for a four-stage brush seal

    NASA Astrophysics Data System (ADS)

    Conner, Kelly J.; Childs, Dara W.

    1993-06-01

    Experimental results are presented for the direct and cross-coupled stiffness and direct damping coefficients for a four-stage brush seal. Variable test parameters include the inlet pressure, pressure ratio, shaft speed, fluid prerotation, and seal spacing. Direct damping slightly increases with running speed; otherwise, the rotordynamic coefficients are relatively insensitive to changes in the test parameters. Cross-coupled stiffness is generally unchanged by increasing the inlet tangential velocity to the seals, in contrast to conventional labyrinth seals. Comparisons of test results for the four-stage brush seal with an eight-cavity labyrinth showed superior rotordynamic performance for the brush seal, namely, larger values for direct stiffness and lower values for the (destabilizing) cross-coupled stiffness coefficient.

  6. Generalized entering coefficients: A criterion for foam stability against oil in porous media

    SciTech Connect

    Bergeron, V.; Fagan, M.E.; Radke, C.J.

    1993-09-01

    The unique mobility-control properties of foam in porous media make it an attractive choice as an injection fluid for enhanced oil recovery. Unfortunately, in many cases oil has a major destabilizing effect on foam. Therefore, it is important to understand how oil destabilizes foam and what surfactant properties lead to increased stability against oil. To explain the stability of foam in porous media in the presence of oil, we generalize the ideas of spreading and entering behavior using Frumkin-Deryaguin wetting theory. This formulation overcomes the inherent deficiencies in the classical spreading and entering coefficients used to explain foam stability against oil. We find that oil-tolerant foam can be produced by making the oil surface ``water wet``. To test our theoretical ideas, we measure foam-flow resistance through 45--70 {mu}m glass beadpacks, surface and interfacial tensions, and disjoining pressure isotherms for foam and pseudoemulsion films for a variety of surfactant/oil systems. Most notably, we measure pseudoemulsion-film disjoining pressure isotherms for the first time and directly establish that pseudoemulsion film stability controls the stability of the foam in the systems we tested. Moreover, we demonstrate the correspondence between stable pseudoemulsion films, negative entering behavior, and oil-tolerant foams.

  7. Comparing Regression Coefficients between Nested Linear Models for Clustered Data with Generalized Estimating Equations

    ERIC Educational Resources Information Center

    Yan, Jun; Aseltine, Robert H., Jr.; Harel, Ofer

    2013-01-01

    Comparing regression coefficients between models when one model is nested within another is of great practical interest when two explanations of a given phenomenon are specified as linear models. The statistical problem is whether the coefficients associated with a given set of covariates change significantly when other covariates are added into…

  8. Generalized non-local surface susceptibility model and Fresnel coefficients for the characterization of periodic metafilms with bianisotropic scatterers

    SciTech Connect

    Dimitriadis, Alexandros I.; Kantartzis, Nikolaos V.; Tsiboukis, Theodoros D.; Hafner, Christian

    2015-01-15

    Highlights: •Formulas for E/M fields radiated by continuous surface polarization distributions. •Non-local effective surface susceptibility model for periodic metafilms. •Generalized reflection and transmission coefficients for an arbitrary metafilm. •Successful treatment of non-planar scatterer arrays and spatial dispersion effects. -- Abstract: A non-local surface susceptibility model for the consistent description of periodic metafilms formed by arbitrarily-shaped, electrically-small, bianisotropic scatterers is developed in this paper. The rigorous scheme is based on the point-dipole approximation technique and is valid for any polarization and propagation direction of an electromagnetic wave impinging upon the metafilm, unlike existing approaches whose applicability is practically confined to very specific cases of incidence. Next, the universal form of the resulting surface susceptibility matrix is employed for the derivation of the generalized Fresnel coefficients for such surfaces, which enable the comprehensive interpretation of several significant, yet relatively unexamined, physical interactions. Essentially, these coefficients include eight distinct terms, corresponding to the co-polarized and cross-polarized reflection and transmission coefficients for the two orthogonal eigenpolarizations of a linearly-polarized incident plane wave. The above formulas are, then, utilized for the prediction of the scattering properties of metafilms with different planar and non-planar resonators, which are characterized via the featured model and two previously reported local ones. Their comparison with numerical simulation outcomes substantiates the merits of the proposed method, reveals important aspects of the underlying physics, and highlights the differences between the various modeling procedures.

  9. Stiffness has different meanings, I think, to everyone”. Examining Stiffness from the Perspective of People Living with Rheumatoid Arthritis

    PubMed Central

    Orbai, Ana-Maria; Smith, Katherine C.; Bartlett, Susan J.; De Leon, Elaine; Bingham, Clifton O.

    2014-01-01

    Objective Stiffness is a well-recognized symptom of Rheumatoid Arthritis (RA). It is frequently queried during clinic visits as an indicator of disease activity, and was included in the 1961 and 1987 RA classification criteria. Little is known about how people with RA experience stiffness and its impact on their lives. Methods We conducted 4 focus groups with 20 people with RA (4-6 participants per group), from one academic clinical practice and one private practice, to generate accounts of stiffness experiences. Qualitative inductive thematic data analysis was conducted. Results Five overarching themes were identified: 1. Relationship of stiffness with other symptoms; 2. Exacerbating or alleviating factors and self-management; 3. Stiffness timing and location; 4. Individual meanings of stiffness experiences; 5. Impact of stiffness on daily life. Conclusion Focus group discussions revealed individual stiffness experiences as diverse and complex. Several stiffness features were endorsed by a majority of participants, but few, if any, were universally experienced, thus the significance of stiffness as an expression of the disease varied widely. Discussions yielded descriptions of how individual limits imposed by RA in general and stiffness in particular, may change over time and were intertwined with adaptations to preserve participation in valued life activities. These results concerning the diversity of the stiffness experience, consequential adaptations, and its impact suggest a more individualized approach to stiffness measurement may be needed in order to improve stiffness assessments. PMID:24891304

  10. Theory versus experiment for the rotordynamic coefficients of annular gas seals. II - Constant-clearance and convergent-tapered geometry

    NASA Technical Reports Server (NTRS)

    Nelson, C. C.; Childs, D. W.; Nicks, C.; Elrod, D.

    1985-01-01

    The leakage and rotordynamic coefficients of constant-clearance and convergent-tapered annular gas seals were measured in an experimental test facility. The results are presented along with the theoretically predicted values. Of particular interest is the prediction that optimally tapered seals have significantly larger direct stiffness than straight seals. The experimental results verify this prediction. Generally the theory does quite well, but fails to predict the large increase in direct stiffness when the fluid is pre-rotated.

  11. Characteristics of high-stiffness superconducting bearing

    SciTech Connect

    Okano, M.; Tamada, N.; Fuchino, S.; Ishii, I.

    1996-07-01

    Magnetic bearings using a high-Tc superconductor have been studied. Generally the bearing makes use of the pinning effects to get the levitation force. The stiffness of the bearing, however, is extremely low as compared with industrial-scale conventional one. To improve the bearing stiffness the authors propose a disc-type repulsive superconducting thrust bearing with a slit for the restraint of the flux. Both theoretical and experimental evaluation on the load performance was carried out, and it is clarified that the proposed superconducting bearing has higher stiffness.

  12. Convergence Rate for Discrete-Time Multiagent Systems With Time-Varying Delays and General Coupling Coefficients.

    PubMed

    Chen, Yao; Ho, Daniel W C; Lu, Jinhu; Lin, Zongli

    2016-01-01

    Multiagent systems (MASs) are ubiquitous in our real world. There is an increasing attention focusing on the consensus (or synchronization) problem of MASs over the past decade. Although there are numerous results reported on the convergence of a discrete-time MAS based on the infinite products of matrices, few results are on the convergence rate. Because of the switching topology, the traditional eigenvalue analysis and the Lyapunov function methods are both invalid for the convergence rate analysis of an MAS with a switching topology. Therefore, the estimation of the convergence rate for a discrete-time MAS with time-varying delays remains a difficult problem. To overcome the essential difficulty of switching topology, this paper aims at developing a contractive-set approach to analyze the convergence rate of a discrete-time MAS in the presence of time-varying delays and generalized coupling coefficients. Using the proposed approach, we obtain an upper bound of the convergence rate under the condition of joint connectivity. In particular, the proposed method neither requires the nonnegative property of the coupling coefficients nor the basic assumption of a uniform lower bound for all positive coupling coefficients, which have been widely applied in the existing works on this topic. As an application of the main results, we will show that the classical Vicsek model with time delays can realize synchronization if the initial topology is connected. PMID:26357412

  13. Magnetic negative stiffness dampers

    NASA Astrophysics Data System (ADS)

    Shi, Xiang; Zhu, Songye

    2015-07-01

    This communication presents the design principle and experimental validation of two novel configurations of magnetic negative stiffness dampers (MNSDs), both of which are composed of several permanent magnets arranged in a conductive pipe. The MNSD, as a passive device, efficiently integrates negative stiffness and eddy-current damping in a simple and compact design, in which the negative stiffness behavior depends on the different arrangements of the permanent magnets. When applied to structural vibration control, passive MNSD may achieve a performance comparable with semi-active or active control in some applications. Laboratory experiments of small-scale prototypes successfully verified the proposed MNSD design concept.

  14. Stiff Quantum Polymers

    E-print Network

    H. Kleinert

    2007-05-01

    At ultralow temperatures, polymers exhibit quantum behavior, which is calculated here for the moments and of the end-to-end distribution in the large-stiffness regime. The result should be measurable for polymers in wide optical traps.

  15. High air-bearing stiffness slider design

    NASA Astrophysics Data System (ADS)

    Han, Y. F.; Liu, B.; Huang, X. Y.

    2006-08-01

    This paper discusses the approach to design air bearing surface (ABS), which can achieve high air bearing (AB) stiffness and high air pressure (AP). Generally, in order to reduce flying height variation and improve the slider's flying stability, high AB stiffness and high AP are preferred. AB stiffness and AP is very sensitive to the slider's ABS design. The flying height and flying attitude of slider is realized by ABS design. According to our study, flying stability of slider is also affected by ABS design. The slider has higher AB stiffness and higher air pressure; it is going to fly more stable. [E.M. Jayson, J. Murphy, P.W. Smith, F.E. Talke. J. Tribol. 125 (2003) 343; W.C. Choi, Y.H. Shin, J.H. Choi. JSME Int. J. 44 (2001) 470.] In order to increase highly the AB stiffness and AP, a dual shallow step structure in a slider is explored. It proved that the dual shallow step structure-increases the air bearing stiffness and the AP on the head area significantly. The structure of central trailing pad is found to have much higher influences on the AB stiffness and AP than the other pads. Optimizing the structure of central trailing pad in the dual shallow step structure slider can further increase the AB stiffness and AP. Finally, the optimized dual shallow step structure slider has much higher AB stiffness and much greater AP on the head area than the normal single shallow step slider. Therefore, the flying stability of the slider with optimized dual shallow step structure should be better.

  16. Two Similarity Reductions and New Solutions for the Generalized Variable-Coefficient KdV Equation by Using Symmetry Group Method

    E-print Network

    Rehab M. El-Shiekh

    2015-12-14

    In this paper, a generalized variable-coefficient KdV equation (vcKdV) arising in fluid mechanics, plasma physics and ocean dynamics is investigated by using symmetry group analysis. Two basic generators are determined, and for every generator in the optimal system the admissible forms of the coefficients and the corresponding reduced ordinary differential equation are obtained. The search for solutions to those reduced ordinary differential equations yields many new solutions for the generalized vcKdV equation.

  17. A Novel Computational Model for Tilting Pad Journal Bearings with Soft Pivot Stiffnesses 

    E-print Network

    Tao, Yujiao 1988-

    2012-12-10

    impedance coefficients, in particular at high whirl frequencies. The stiffness and damping coefficients of a TPJB increase with a reduction in the operating bearing and pad clearances. The work delivers a predictive tool benchmarked against a number...

  18. Stiff quantum polymers

    E-print Network

    H. Kleinert

    2009-10-19

    At ultralow temperatures, polymers exhibit quantum behavior, which is calculated here for the second and fourth moments of the end-to-end distribution in the large-stiffness regime. The result should be measurable for polymers in wide optical traps.

  19. Measuring graphene's bending stiffness

    NASA Astrophysics Data System (ADS)

    Blees, Melina; Barnard, Arthur; Roberts, Samantha; Kevek, Joshua W.; Ruyack, Alexander; Wardini, Jenna; Ong, Peijie; Zaretski, Aliaksandr; Wang, Siping; McEuen, Paul L.

    2013-03-01

    Graphene's unusual combination of in-plane strength and out-of-plane flexibility makes it promising for mechanical applications. A key value is the bending stiffness, which microscopic theories and measurements of phonon modes in graphite put at ?0 = 1.2 eV.1 However, theories of the effects of thermal fluctuations in 2D membranes predict that the bending stiffness at longer length scales could be orders of magnitude higher.2,3 This macroscopic value has not been measured. Here we present the first direct measurement of monolayer graphene's bending stiffness, made by mechanically lifting graphene off a surface in a liquid and observing both motion induced by thermal fluctuations and the deflection caused by gravity's effect on added weights. These experiments reveal a value ?eff = 12 keV at room temperature -- four orders of magnitude higher than ?0. These results closely match theoretical predictions of the effects of thermally-induced fluctuations which effectively thicken the membrane, dramatically increasing its bending stiffness at macroscopic length scales.

  20. Rotordynamic force coefficients of pocket damper seals 

    E-print Network

    Ertas, Bugra Han

    2005-11-01

    fundamental of levels. The results indicated that the conventional PDS possessed high positive damping, negative and positive stiffness, and same sign cross-coupled coefficients. Another objective of the work is to investigate a new fully partitioned PDS...

  1. Nonlinear stability of oscillatory core-annular flow: A generalized Kuramoto-Sivashinsky equation with time periodic coefficients

    NASA Technical Reports Server (NTRS)

    Coward, Adrian V.; Papageorgiou, Demetrios T.; Smyrlis, Yiorgos S.

    1994-01-01

    In this paper the nonlinear stability of two-phase core-annular flow in a pipe is examined when the acting pressure gradient is modulated by time harmonic oscillations and viscosity stratification and interfacial tension is present. An exact solution of the Navier-Stokes equations is used as the background state to develop an asymptotic theory valid for thin annular layers, which leads to a novel nonlinear evolution describing the spatio-temporal evolution of the interface. The evolution equation is an extension of the equation found for constant pressure gradients and generalizes the Kuramoto-Sivashinsky equation with dispersive effects found by Papageorgiou, Maldarelli & Rumschitzki, Phys. Fluids A 2(3), 1990, pp. 340-352, to a similar system with time periodic coefficients. The distinct regimes of slow and moderate flow are considered and the corresponding evolution is derived. Certain solutions are described analytically in the neighborhood of the first bifurcation point by use of multiple scales asymptotics. Extensive numerical experiments, using dynamical systems ideas, are carried out in order to evaluate the effect of the oscillatory pressure gradient on the solutions in the presence of a constant pressure gradient.

  2. Seismogram synthesis for radially layered media using the generalized reflection/transmission coefficients method: Theory and applications to acoustic logging

    SciTech Connect

    Chen, X.; Quan, Y.; Harris, J.M.

    1996-07-01

    A new method based on generalized reflection and transmission coefficients is proposed to calculate the synthetic seismograms in radially multilayered media. This method can be used to efficiently simulate full waveform acoustic logs and crosswell seismic profiles in situations where one needs to consider borehole effects. The new formulation is tested by comparing the authors` numerical results with previous available work and shows excellent agreement. Because of the use of the normalized Hankel functions and the normalization factors, this new algorithm for computing seismograms is stable numerically even for high-frequency problems. To show the applicability of this new approach to full waveform sonic logging, they apply it to investigate the effects of complex invaded zones on the geometrical spreading and attenuation estimation for P-waves. They find that a damaged zone (its velocity is slower than the unperturbed formation velocity) exhibits a convergence effect on the P-waves, and a flushed zone (velocity is faster than the unperturbed formation velocity) exhibits a divergence effect on the P-waves.

  3. A general formula for computing the coefficients of the correlation connecting global solar radiation to sunshine duration

    SciTech Connect

    Gopinathan, K.K. )

    1988-01-01

    Correlations are developed to estimate the regression coefficients a and b of {Angstrom} type correlations for predicting monthly mean daily global solar radiation on a horizontal surface. The suggested equations express the regression coefficients in terms of the latitude, elevation, and percent of possible sunshine and are applicable to any location around the world to compute global solar radiation on horizontal surfaces.

  4. A new theory for multistep discretizations of stiff ordinary differential equations: Stability with large step sizes

    NASA Technical Reports Server (NTRS)

    Majda, G.

    1985-01-01

    A large set of variable coefficient linear systems of ordinary differential equations which possess two different time scales, a slow one and a fast one is considered. A small parameter epsilon characterizes the stiffness of these systems. A system of o.d.e.s. in this set is approximated by a general class of multistep discretizations which includes both one-leg and linear multistep methods. Sufficient conditions are determined under which each solution of a multistep method is uniformly bounded, with a bound which is independent of the stiffness of the system of o.d.e.s., when the step size resolves the slow time scale, but not the fast one. This property is called stability with large step sizes. The theory presented lets one compare properties of one-leg methods and linear multistep methods when they approximate variable coefficient systems of stiff o.d.e.s. In particular, it is shown that one-leg methods have better stability properties with large step sizes than their linear multistep counter parts. The theory also allows one to relate the concept of D-stability to the usual notions of stability and stability domains and to the propagation of errors for multistep methods which use large step sizes.

  5. On Zero Stiffness

    E-print Network

    Schenk, Mark; Guest, Simon D.

    2013-11-17

    review by Ibrahim [18] covers a wide range of non-linear passive vibration isolators, including mechanical structures such as postbuckled beams, as well as magnetic quasi-zero stiffness systems [20]. For most vibration isolation applications, the use of a... Technical Conferences and Computers and Infor- mation in Engineering Conference (IDETC/CIE2009). DETC2009-87451. San Diego, California, USA; 2009. p. 313–323. [18] Ibrahim RA. Recent advances in nonlinear passive vibration isolators. Jour- nal of Sound...

  6. Auto-Baecklund transformation and new exact solutions of the generalized variable-coefficients two-dimensional Korteweg-de Vries model

    SciTech Connect

    Li Yezhou; Liu Jianguo

    2007-02-15

    Describing plasma physics, cluster physics, and geophysical fluid dynamics, a generalized variable-coefficient two-dimensional Korteweg-de Vries (GVCKdV) model is hereby under investigation. In this paper, an extended-variable-coefficient homogeneous balance method with symbolic computation is used to obtain an auto-Baecklund transformation, some rational solutions, and new soliton-type solutions for the GVCKdV model. The solutions of the well-known cylindrical Kadomtsev-Petviashvili equation can be recovered as special cases of the results obtained here.

  7. Cosmology with a stiff matter era

    E-print Network

    Pierre-Henri Chavanis

    2014-11-27

    We provide a simple analytical solution of the Friedmann equations for a universe made of stiff matter, dust matter, and dark energy. A stiff matter era is present in the cosmological model of Zel'dovich (1972) where the primordial universe is assumed to be made of a cold gas of baryons. It also occurs in certain cosmological models where dark matter is made of relativistic self-gravitating Bose-Einstein condensates (BECs). When the energy density of the stiff matter is positive, the primordial universe is singular. It starts from a state with a vanishing scale factor and an infinite density. We consider the possibility that the energy density of the stiff matter is negative (anti-stiff matter). This happens, for example, when the BECs have an attractive self-interaction. In that case, the primordial universe is non-singular. It starts from a state in which the scale factor is finite and the energy density is equal to zero. For the sake of generality, we consider a cosmological constant of arbitrary sign. When the cosmological constant is positive, the universe asymptotically reaches a de Sitter phase where the scale factor increases exponentially rapidly. This can account for the accelerating expansion of the universe that we observe at present. When the cosmological constant is negative (anti-de Sitter), the evolution of the universe is cyclic. Therefore, depending on the sign of the energy density of the stiff matter and of the dark energy, we obtain singular and non-singular expanding or cyclic universes.

  8. Stiffness, thermal expansion, and thermal bending formulation of stiffened, fiber-reinforced composite panels

    NASA Astrophysics Data System (ADS)

    Collier, Craig S.

    1993-04-01

    A method is presented for formulating stiffness terms and thermal coefficients of stiffened, fiber-reinforced composite panels. The method is robust enough to handle panels with general cross sectional shapes, including those which are unsymmetric and/or unbalanced. Nonlinear, temperature and load dependent constitutive material data of each laminate are used to 'build-up' the stiffened panel membrane, bending, and membrane-bending coupling stiffness terms and thermal coefficients. New thermal coefficients are introduced to quantify panel response from through-the-thickness temperature gradients. A technique of implementing this capability with a single plane of shell finite elements using the MSC/NASTRAN analysis program (FEA) is revealed that provides accurate solutions of entire airframes or engines with coarsely meshed models. An example of a composite, hat-stiffened panel is included to demonstrate errors that occur when an unsymmetric panel is symmetrically formulated as traditionally done. The erroneous results and the correct ones produced from this method are compared to analysis from discretely meshed three-dimensional FEA.

  9. Stiff, strong, and tough hydrogels with good chemical stability

    E-print Network

    Suo, Zhigang

    water content of the resulting gels increased with acrylamide content, while the coefficient of friction require high stiffness (1 MPa), high toughness (1000 J m�2 ), and high water content (60­ 80%).5 Materials- tion, sustain sealing pressure (up to 34 MPa) and be stable in saline water.3 Materials for articial

  10. Multisoliton solutions in terms of double Wronskian determinant for a generalized variable-coefficient nonlinear Schroedinger equation from plasma physics, arterial mechanics, fluid dynamics and optical communications

    SciTech Connect

    Lue Xing Zhu Hongwu; Yao Zhenzhi; Meng Xianghua; Zhang Cheng; Zhang Chunyi; Tian Bo

    2008-08-15

    In this paper, the multisoliton solutions in terms of double Wronskian determinant are presented for a generalized variable-coefficient nonlinear Schroedinger equation, which appears in space and laboratory plasmas, arterial mechanics, fluid dynamics, optical communications and so on. By means of the particularly nice properties of Wronskian determinant, the solutions are testified through direct substitution into the bilinear equations. Furthermore, it can be proved that the bilinear Baecklund transformation transforms between (N - 1)- and N-soliton solutions.

  11. The generalized correlation for the evaluation of the influence of the Stefan flow on the heat transfer coefficient

    NASA Astrophysics Data System (ADS)

    Baskakov, A. P.; Rakov, O. A.

    2013-11-01

    The analytical equations for the steady-state heat-and-mass transfer in the steam evaporation/condensation processes from the steam-gas mixtures on the planar and spherical surfaces are derived. The vapor flow through the motionless dry gas is considered according to the method proposed by Maxwell for the solution of the diffusion problems. The relationships for the calculation of the coefficients taking into account an increase in the mass output and an increase or a decrease in the heat emission (depending on the directions of the heat-and-mass flows) as a result of the influence of the Stefan flow are presented. The derived relationships can be used to calculate the apparatuses in which the steam evaporation or condensation from the steam-gas mixture occurs (the coolers of the vapor from deaerators, the apparatuses for the deep utilization of the heat of the combustion products, the condensation boilers, etc.).

  12. Fluid damping and fluid stiffness of tube arrays in crossflow

    SciTech Connect

    Chen, S.S.; Zhu, S.; Jendrzejczyk, J.A.

    1994-06-01

    Motion-dependent fluid forces acting on a tube array were measured as a function of excitation frequency, excitation amplitude, and flow velocity. Fluid-damping and fluid-stiffness coefficients were obtained from measured motion-dependent fluid forces as a function of reduced flow velocity and excitation amplitude. The water channel and test setup provide a sound facility for obtaining key coefficients for fluidelastic instability of tube arrays in crossflow. Once the motion-dependent fluid-force coefficients have been measured, a reliable design guideline, based on the unsteady flow theory, can be developed for fluidelastic instability of tube arrays in crossflow.

  13. Switchable stiffness scanning microscope probe

    E-print Network

    Mueller-Falcke, Clemens T. (Clemens Tobias)

    2005-01-01

    Atomic Force Microscopy (AFM) has rapidly gained widespread utilization as an imaging device and micro/nano-manipulator during recent years. This thesis investigates the new concept of a dual stiffness scanning probe with ...

  14. General model for estimating partition coefficients to organisms and their tissues using the biological compositions and polyparameter linear free energy relationships.

    PubMed

    Endo, Satoshi; Brown, Trevor N; Goss, Kai-Uwe

    2013-06-18

    Equilibrium partition coefficients of organic chemicals from water to an organism or its tissues are typically estimated by using the total lipid content in combination with the octanol-water partition coefficient (K(ow)). This estimation method can cause systematic errors if (1) different lipid types have different sorptive capacities, (2) nonlipid components such as proteins have a significant contribution, and/or (3) K(ow) is not a suitable descriptor. As an alternative, this study proposes a more general model that uses detailed organism and tissue compositions (i.e., contents of storage lipid, membrane lipid, albumin, other proteins, and water) and polyparameter linear free energy relationships (PP-LFERs). The values calculated by the established PP-LFER-composition-based model agree well with experimental in vitro partition coefficients and in vivo steady-state concentration ratios from the literature with a root mean squared error of 0.32-0.53 log units, without any additional fitting. This model estimates a high contribution of the protein fraction to the overall tissue sorptive capacity in lean tissues (e.g., muscle), in particular for H-bond donor polar compounds. Direct model comparison revealed that the simple lipid-octanol model still calculates many tissue-water partition coefficients within 1 log unit of those calculated by the PP-LFER-composition-based model. Thus, the lipid-octanol model can be used as an order-of-magnitude approximation, for example, for multimedia fate modeling, but may not be suitable for more accurate predictions. Storage lipid-rich phases (e.g., adipose, milk) are prone to particularly large systematic errors. The new model provides useful implications for validity of lipid-normalization of concentrations in organisms, interpretation of biomonitoring results, and assessment of toxicity. PMID:23672211

  15. Theory versus experiment for the rotordynamic coefficients of annular gas seals. Part 2: Constant clearance and convergent-tapered geometry

    NASA Technical Reports Server (NTRS)

    Nelson, C. C.; Childs, D. W.; Nicks, C.; Elrod, D.

    1985-01-01

    The leakage and rotordynamic coefficients of constant-clearance and convergent-tapered annular gas seals were measured in an experimental test facility. The results are presented along with the theoretically predicted values. Of particular interest is the prediction that optimally tapered seals have significantly larger direct siffness than straight seals. The experimental results verify this prediction. Generally the theory does quite well, but fails to predict the large increase in direct stiffness when the fluid is pre-rotated.

  16. Experimental determination of dynamic force coefficients of a pocket damper seal at higher frequencies 

    E-print Network

    Sharma, Ashish

    2001-01-01

    Experimental results are presented for a two-bladed pocket damper seal (PDS) with eight partition walls on a high-speed test rig. The objective of these experiments is to measure damping coefficients, stiffness coefficients and leakage rates...

  17. Positive Association Between Adipose Tissue and Bone Stiffness.

    PubMed

    Berg, R M; Wallaschofski, H; Nauck, M; Rettig, R; Markus, M R P; Laqua, R; Friedrich, N; Hannemann, A

    2015-07-01

    Obesity is often considered to have a protective effect against osteoporosis. On the other hand, several recent studies suggest that adipose tissue may have detrimental effects on bone quality. We therefore aimed to investigate the associations between body mass index (BMI), waist circumference (WC), visceral adipose tissue (VAT) or abdominal subcutaneous adipose tissue (SAT), and bone stiffness. The study involved 2685 German adults aged 20-79 years, who participated in either the second follow-up of the population-based Study of Health in Pomerania (SHIP-2) or the baseline examination of the SHIP-Trend cohort. VAT and abdominal SAT were quantified by magnetic resonance imaging. Bone stiffness was assessed by quantitative ultrasound (QUS) at the heel (Achilles InSight, GE Healthcare). The individual risk for osteoporotic fractures was determined based on the QUS-derived stiffness index and classified in low, medium, and high risk. Linear regression models, adjusted for sex, age, physical activity, smoking status, risky alcohol consumption, diabetes, and height (in models with VAT or abdominal SAT as exposure), revealed positive associations between BMI, WC, VAT or abdominal SAT, and the QUS variables broadband-ultrasound attenuation or stiffness index. Moreover, BMI was positively associated with speed of sound. Our study shows that all anthropometric measures including BMI and, WC as well as abdominal fat volume are positively associated with bone stiffness in the general population. As potential predictors of bone stiffness, VAT and abdominal SAT are not superior to easily available measures like BMI or WC. PMID:25929703

  18. Cosmology with a stiff matter era

    NASA Astrophysics Data System (ADS)

    Chavanis, Pierre-Henri

    2015-11-01

    We consider the possibility that the Universe is made of a dark fluid described by a quadratic equation of state P =K ?2 , where ? is the rest-mass density and K is a constant. The energy density ? =? c2+K ?2 is the sum of two terms: a rest-mass term ? c2 that mimics "dark matter" (P =0 ) and an internal energy term u =K ?2=P that mimics a "stiff fluid" (P =? ) in which the speed of sound is equal to the speed of light. In the early universe, the internal energy dominates and the dark fluid behaves as a stiff fluid (P ˜? , ? ?a-6). In the late universe, the rest-mass energy dominates and the dark fluid behaves as pressureless dark matter (P ?0 , ? ?a-3). We provide a simple analytical solution of the Friedmann equations for a universe undergoing a stiff matter era, a dark matter era, and a dark energy era due to the cosmological constant. This analytical solution generalizes the Einstein-de Sitter solution describing the dark matter era, and the ? CDM model describing the dark matter era and the dark energy era. Historically, the possibility of a primordial stiff matter era first appeared in the cosmological model of Zel'dovich where the primordial universe is assumed to be made of a cold gas of baryons. A primordial stiff matter era also occurs in recent cosmological models where dark matter is made of relativistic self-gravitating Bose-Einstein condensates (BECs). When the internal energy of the dark fluid mimicking stiff matter is positive, the primordial universe is singular like in the standard big bang theory. It expands from an initial state with a vanishing scale factor and an infinite density. We consider the possibility that the internal energy of the dark fluid is negative (while, of course, its total energy density is positive), so that it mimics anti-stiff matter. This happens, for example, when the BECs have an attractive self-interaction with a negative scattering length. In that case, the primordial universe is nonsingular and bouncing like in loop quantum cosmology. At t =0 , the scale factor is finite and the energy density is equal to zero. The universe first has a phantom behavior where the energy density increases with the scale factor, then a normal behavior where the energy density decreases with the scale factor. For the sake of generality, we consider a cosmological constant of arbitrary sign. When the cosmological constant is positive, the Universe asymptotically reaches a de Sitter regime where the scale factor increases exponentially rapidly with time. This can account for the accelerating expansion of the Universe that we observe at present. When the cosmological constant is negative (anti-de Sitter), the evolution of the Universe is cyclic. Therefore, depending on the sign of the internal energy of the dark fluid and on the sign of the cosmological constant, we obtain analytical solutions of the Friedmann equations describing singular and nonsingular expanding, bouncing, or cyclic universes.

  19. Lase Ultrasonic Web Stiffness tester

    SciTech Connect

    Tim Patterson, Ph.D., IPST at Ga Tech

    2009-01-12

    The objective is to provide a sensor that uses non-contact, laser ultrasonics to measure the stiffness of paper during the manufacturing process. This will allow the manufacturer to adjust the production process in real time, increase filler content, modify fiber refining and as result produce a quality product using less energy. The sensor operates by moving back and forth across the paper web, at pre-selected locations firing a laser at the sheet, measuring the out-of-plane velocity of the sheet then using that measurement to calculate sheet stiffness.

  20. On quasi-periodic wave solutions and asymptotic behaviors to a (2 + 1)-dimensional generalized variable-coefficient Sawada-Kotera equation

    NASA Astrophysics Data System (ADS)

    Tu, Jian-Min; Tian, Shou-Fu; Xu, Mei-Juan; Ma, Pan-Li

    2015-07-01

    In this paper, a (2 + 1)-dimensional generalized variable-coefficient Sawada-Kotera (gvcSK) equation is investigated, which describes many nonlinear phenomena in fluid dynamics and plasma physics. Based on the properties of binary Bell polynomials, we present a Hirota’s bilinear equation to the gvcSK equation. By virtue of the Hirota’s bilinear equation, we obtain the N-soliton solutions and the quasi-periodic wave solutions of the gvcSK equation, which can be reduced to the ones of several integrable equations such as Sawada-Kotera, modified Caudrey-Dodd-Gibbon-Sawada-Kotera, isospectral BKP equations and etc. Furthermore, we obtain the relationship between the soliton solutions and periodic solutions by considering the asymptotic properties of the periodic solutions.

  1. Integrability aspects with optical solitons of a generalized variable-coefficient N-coupled higher order nonlinear Schroedinger system from inhomogeneous optical fibers

    SciTech Connect

    Lue Xing; Li Juan; Zhang Haiqiang; Xu Tao; Li Lili; Tian Bo

    2010-04-15

    For describing the long-distance communication and manufacturing problems of N fields propagation in inhomogeneous optical fibers, we consider a generalized variable-coefficient N-coupled nonlinear Schroedinger system with higher order effects such as the third-order dispersion, self-steepening and self-frequency shift. Using the Painleve singularity structure analysis, we obtain two cases for this system to admit the Painleve property. Then for case (1) we derive the optical dark solitons via solving the Hirota bilinear equations; and based on the obtained (2N+1)x(2N+1) Lax pair, we construct the Darboux transformation to obtain the optical bright solitons (including the multisoliton profiles) for case (2). Finally, the features of optical solitons (both dark and bright ones) in inhomogeneous optical fibers are analyzed and graphically discussed.

  2. Bending Stiffness of Multiwall Sandwich

    NASA Technical Reports Server (NTRS)

    Blosser, M. L.

    1983-01-01

    An analytical and experimental study was carried out to understand the extensional and flexural behavior of multiwall sandwich, a metallic insulation composed of alternate layers of flat and dimpled foil. The multiwall sandwich was structurally analyzed by using several simplifying assumptions combined with a finite element analysis. The simplifying assumptions made in this analysis were evaluated by bending and tensile tests. Test results validate the assumption that flat sheets in compression do not significantly contribute to the flexural stiffness of multiwall sandwich for the multiwall geometry tested. However, calculations show that thicker flat sheets may contribute significantly to bending stiffness and cannot be ignored. Results of this analytical approach compare well with test data; both show that the extensional stiffness of the dimpled sheet in he 0 deg direction is about 30 percent of that for a flat sheet, and that in the 45 deg direction, it is about 10 percent. The analytical and experimental multiwall bending stiffness showed good agreement for the particular geometry tested.

  3. Arterial Stiffness and Cardiovascular Therapy

    PubMed Central

    Jani?, Miodrag; Lunder, Mojca; Šabovi?, Mišo

    2014-01-01

    The world population is aging and the number of old people is continuously increasing. Arterial structure and function change with age, progressively leading to arterial stiffening. Arterial stiffness is best characterized by measurement of pulse wave velocity (PWV), which is its surrogate marker. It has been shown that PWV could improve cardiovascular event prediction in models that included standard risk factors. Consequently, it might therefore enable better identification of populations at high-risk of cardiovascular morbidity and mortality. The present review is focused on a survey of different pharmacological therapeutic options for decreasing arterial stiffness. The influence of several groups of drugs is described: antihypertensive drugs (angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, calcium channel blockers, beta-blockers, diuretics, and nitrates), statins, peroral antidiabetics, advanced glycation end-products (AGE) cross-link breakers, anti-inflammatory drugs, endothelin-A receptor antagonists, and vasopeptidase inhibitors. All of these have shown some effect in decreasing arterial stiffness. Nevertheless, further studies are needed which should address the influence of arterial stiffness diminishment on major adverse cardiovascular and cerebrovascular events (MACCE). PMID:25170513

  4. Calculation of the aerodynamic loading of swept and unswept flexible wings of arbitrary stiffness

    NASA Technical Reports Server (NTRS)

    Diederich, Franklin W

    1950-01-01

    A method is presented for calculating the aerodynamic loading, the divergence speed, and certain stability derivatives of swept and unswept wings and tail surfaces of arbitrary stiffness. Provision is made for using either stiffness curves and root rotation constants or structural influence coefficients in the analysis. Computing forms, tables of numerical constants required in the analysis, and an illustrative example are included to facilitate calculations by means of the method.

  5. Experimental dynamic stiffness and damping of externally pressurized gas-lubricated journal bearings

    NASA Technical Reports Server (NTRS)

    Fleming, D. P.; Thayer, W. J.; Cunningham, R. E.

    1976-01-01

    A rigid vertical shaft was operated with known amounts of unbalance at speeds to 30,000 rpm and gas supply pressure ratios to 4.8. From measured amplitude and phase angle data, dynamic stiffness and damping coefficients of the bearings were determined. The measured stiffness was proportional to the supply pressure, while damping was little affected by supply pressure. Damping dropped rapidly as the fractional frequency whirl threshold was approached. A small-eccentricity analysis overpredicted the stiffness by 20 to 70 percent. Predicted damping was lower than measured at low speeds but higher at high speeds.

  6. Simple Formulas and Results for Buckling-Resistance and Stiffness Design of Compression-Loaded Laminated-Composite Cylinders

    NASA Technical Reports Server (NTRS)

    Nemeth, Michael P.; Mikulas, Martin M., Jr.

    2009-01-01

    Simple formulas for the buckling stress of homogeneous, specially orthotropic, laminated-composite cylinders are presented. The formulas are obtained by using nondimensional parameters and equations that facilitate general validation, and are validated against the exact solution for a wide range of cylinder geometries and laminate constructions. Results are presented that establish the ranges of the nondimensional parameters and coefficients used. General results, given in terms of the nondimensional parameters, are presented that encompass a wide range of geometries and laminate constructions. These general results also illustrate a wide spectrum of behavioral trends. Design-oriented results are also presented that provide a simple, clear indication of laminate composition on critical stress, critical strain, and axial stiffness. An example is provided to demonstrate the application of these results to thin-walled column designs.

  7. Analysis and Design of Variable Stiffness Composite Cylinders

    NASA Technical Reports Server (NTRS)

    Tatting, Brian F.; Guerdal, Zafer

    1998-01-01

    An investigation of the possible performance improvements of thin circular cylindrical shells through the use of the variable stiffness concept is presented. The variable stiffness concept implies that the stiffness parameters change spatially throughout the structure. This situation is achieved mainly through the use of curvilinear fibers within a fiber-reinforced composite laminate, though the possibility of thickness variations and discrete stiffening elements is also allowed. These three mechanisms are incorporated into the constitutive laws for thin shells through the use of Classical Lamination Theory. The existence of stiffness variation within the structure warrants a formulation of the static equilibrium equations from the most basic principles. The governing equations include sufficient detail to correctly model several types of nonlinearity, including the formation of a nonlinear shell boundary layer as well as the Brazier effect due to nonlinear bending of long cylinders. Stress analysis and initial buckling estimates are formulated for a general variable stiffness cylinder. Results and comparisons for several simplifications of these highly complex governing equations are presented so that the ensuing numerical solutions are considered reliable and efficient enough for in-depth optimization studies. Four distinct cases of loading and stiffness variation are chosen to investigate possible areas of improvement that the variable stiffness concept may offer over traditional constant stiffness and/or stiffened structures. The initial investigation deals with the simplest solution for cylindrical shells in which all quantities are constant around the circumference of the cylinder. This axisymmetric case includes a stiffness variation exclusively in the axial direction, and the only pertinent loading scenarios include constant loads of axial compression, pressure, and torsion. The results for these cases indicate that little improvement over traditional laminates exists through the use of curvilinear fibers, mainly due to the presence of a weak link area within the stiffness variation that limits the ultimate load that the structure can withstand. Rigorous optimization studies reveal that even though slight increases in the critical loads can be produced for designs with an arbitrary variation of the fiber orientation angle, the improvements are not significant when compared to traditional design techniques that utilize ring stiffeners and frames. The second problem that is studied involves arbitrary loading of a cylinder with a stiffness variation that changes only in the circumferential direction. The end effects of the cylinder are ignored, so that the problem takes the form of an analysis of a cross-section for a short cylinder segment. Various load cases including axial compression, pressure, torsion, bending, and transverse shear forces are investigated. It is found that the most significant improvements in load-carrying capability exist for cases which involve loads that also vary around the circumference of the shell, namely bending and shear forces. The stiffness variation of the optimal designs contribute to the increased performance in two ways: lowering the stresses in the critical areas through redistribution of the stresses; and providing a relatively stiff region that alters the buckling behavior of the structure. These results lead to an in-depth optimization study involving weight optimization of a fuselage structure subjected to typical design constraints. Comparisons of the curvilinear fiber format to traditional stiffened structures constructed of isotropic and composite materials are included. It is found that standard variable stiffness designs are quite comparable in terms of weight and load-carrying capability yet offer the added advantage of tailorability of distinct regions of the structure that experience drastically different loading conditions. The last two problems presented in this work involve the nonlinear phenomenon of long tubes under bending. Though this scenario is not as applic

  8. Estimation of Quasi-Stiffness of the Human Knee in the Stance Phase of Walking

    PubMed Central

    Shamaei, Kamran; Sawicki, Gregory S.; Dollar, Aaron M.

    2013-01-01

    Biomechanical data characterizing the quasi-stiffness of lower-limb joints during human locomotion is limited. Understanding joint stiffness is critical for evaluating gait function and designing devices such as prostheses and orthoses intended to emulate biological properties of human legs. The knee joint moment-angle relationship is approximately linear in the flexion and extension stages of stance, exhibiting nearly constant stiffnesses, known as the quasi-stiffnesses of each stage. Using a generalized inverse dynamics analysis approach, we identify the key independent variables needed to predict knee quasi-stiffness during walking, including gait speed, knee excursion, and subject height and weight. Then, based on the identified key variables, we used experimental walking data for 136 conditions (speeds of 0.75–2.63 m/s) across 14 subjects to obtain best fit linear regressions for a set of general models, which were further simplified for the optimal gait speed. We found R2 > 86% for the most general models of knee quasi-stiffnesses for the flexion and extension stages of stance. With only subject height and weight, we could predict knee quasi-stiffness for preferred walking speed with average error of 9% with only one outlier. These results provide a useful framework and foundation for selecting subject-specific stiffness for prosthetic and exoskeletal devices designed to emulate biological knee function during walking. PMID:23533662

  9. Difference methods for stiff delay differential equations. [DDESUB, in FORTRAN

    SciTech Connect

    Roth, Mitchell G.

    1980-12-01

    Delay differential equations of the form y'(t) = f(y(t), z(t)), where z(t) = (y/sub 1/(..cap alpha../sub 1/(y(t))),..., y/sub n/(..cap alpha../sub n/(y(t))))/sup T/ and ..cap alpha../sub i/(y(t)) less than or equal to t, arise in many scientific and engineering fields when transport lags and propagation times are physically significant in a dynamic process. Difference methods for approximating the solution of stiff delay systems require special stability properties that are generalizations of those employed for stiff ordinary differential equations. By use of the model equation y'(t) = py(t) + qy(t-1), with complex p and q, the definitions of A-stability, A( )-stability, and stiff stability have been generalize to delay equations. For linear multistep difference formulas, these properties extend directly from ordinary to delay equations. This straight forward extension is not true for implicit Runge-Kutta methods, as illustrated by the midpoint formula, which is A-stable for ordinary equations, but not for delay equations. A computer code for stiff delay equations was developed using the BDF. 24 figures, 5 tables.

  10. Torsional stiffness degradation and aerostatic divergence of suspension bridge decks

    NASA Astrophysics Data System (ADS)

    Zhang, Z. T.; Ge, Y. J.; Yang, Y. X.

    2013-07-01

    The mechanism of aerostatic torsional divergence (ATD) of long-span suspension bridges is investigated. A theoretical analysis on the basis of a generalized model is presented, showing that the vertical motion of a bridge deck is crucial to the torsional stiffness of the whole suspended system, and that the vertical motion of either cable with a magnitude beyond a certain threshold could result in a sudden degradation of the torsional stiffness of the system. This vertical motion-induced degradation of stiffness is recognized as the main reason for the ATD. Long-span suspension bridges are susceptible to such a type of divergence, especially when they are immersed in turbulent wind fields. The divergences that occur in turbulent wind fields differ significantly from those in smooth wind fields, and the difference is well explained by the generalized model that the loosening of any one cable could result in the vanishing of the part of stiffness provided by the whole cable system. The mechanism revealed in this paper leads to a definition of the critical wind speed of the ATD in a turbulent flow; that is, the one resulting in a vertical motion so large as to loosen either cable to a stressless state. Numerical results from the nonlinear finite-element (FE) analysis of the Xihoumen suspension bridge, in conjunction with observations from wind tunnel tests on an aero-elastic full bridge model, are in support of the viewpoint presented in this study.

  11. Modifiable Risk Factors for Increased Arterial Stiffness in Outpatient Nephrology

    PubMed Central

    Elewa, Usama; Fernandez-Fernandez, Beatriz; Alegre, Raquel; Sanchez-Niño, Maria D.; Mahillo-Fernández, Ignacio; Perez-Gomez, Maria Vanessa; El-Fishawy, Hussein; Belal, Dawlat; Ortiz, Alberto

    2015-01-01

    Arterial stiffness, as measured by pulse wave velocity (PWV), is an independent predictor of cardiovascular events and mortality. Arterial stiffness increases with age. However, modifiable risk factors such as smoking, BP and salt intake also impact on PWV. The finding of modifiable risk factors may lead to the identification of treatable factors, and, thus, is of interest to practicing nephrologist. We have now studied the prevalence and correlates of arterial stiffness, assessed by PWV, in 191 patients from nephrology outpatient clinics in order to identify modifiable risk factors for arterial stiffness that may in the future guide therapeutic decision-making. PWV was above normal levels for age in 85/191 (44.5%) patients. Multivariate analysis showed that advanced age, systolic BP, diabetes mellitus, serum uric acid and calcium polystyrene sulfonate therapy or calcium-containing medication were independent predictors of PWV. A new parameter, Delta above upper limit of normal PWV (Delta PWV) was defined to decrease the weight of age on PWV values. Delta PWV was calculated as (measured PWV) - (upper limit of the age-adjusted PWV values for the general population). Mean±SD Delta PWV was 0.76±1.60 m/sec. In multivariate analysis, systolic blood pressure, active smoking and calcium polystyrene sulfonate therapy remained independent predictors of higher delta PWV, while age, urinary potassium and beta blocker therapy were independent predictors of lower delta PWV. In conclusion, arterial stiffness was frequent in nephrology outpatients. Systolic blood pressure, smoking, serum uric acid, calcium-containing medications, potassium metabolism and non-use of beta blockers are modifiable factors associated with increased arterial stiffness in Nephrology outpatients. PMID:25880081

  12. Rolling bearing stiffness in arbitrary direction

    NASA Astrophysics Data System (ADS)

    Luo, Zhusan; Sun, Xinde; Wu, Linfeng

    1992-06-01

    This paper presents a new concept of rolling bearing stiffness in arbitrary direction, which is necessary to the investigation of rotor-bearing dynamics. It includes the axial stiffness and the arbitrary radial stiffness of the rolling bearing. Based on elasticity theory and the geometrical parameters of the bearing, the approximate formulas of the axial stiffness, the arbitrary radial stiffness, and the inner ring displacements are derived. Furthermore, the paper also discusses the effects of the loads, the radial clearance, and the load distribution parameters on the rolling bearing stiffness. In order to verify the model and the computer program, an example of a ball bearing is analyzed in detail. It shows that the model and the program are reliable and the results are consistent with the data supplied by the U.S. Air Force Aeropropulsion Laboratory.

  13. Experimental stiffness of tapered bore seals

    NASA Technical Reports Server (NTRS)

    Fleming, D. P.

    1985-01-01

    The stiffness of tapered-bore ring seals was measured with air as the sealed fluid. Static stiffness agreed fairly well with results of a previous analysis. Cross-coupled stiffness due to shaft rotation was much less than predicted. It is suggested that part of the disparity may be due to simplifying assumptions in the analysis; however, these do not appear to account for the entire difference observed.

  14. Passive Apaptive Damping for High Stiffness-low Mass Materials Incorporating Negative Stiffness Elements 

    E-print Network

    Cha, Gene

    2013-11-07

    High stiffness / low mass materials or structures reduce structure weight in transportation, but show little inherent damping. A new composite material that exhibits high stiffness and high damping might reduce issues with ...

  15. Spinal stiffness changes throughout the respiratory cycle.

    PubMed

    Shirley, D; Hodges, P W; Eriksson, A E M; Gandevia, S C

    2003-10-01

    Posteroanterior stiffness of the lumbar spine is influenced by factors, including trunk muscle activity and intra-abdominal pressure (IAP). Because these factors vary with breathing, this study investigated whether stiffness is modulated in a cyclical manner with respiration. A further aim was to investigate the relationship between stiffness and IAP or abdominal and paraspinal muscle activity. Stiffness was measured from force-displacement responses of a posteroanterior force applied over the spinous process of L2 and L4. Recordings were made of IAP and electromyographic activity from L4/L2 erector spinae, abdominal muscles, and chest wall. Stiffness was measured with the lung volume held at the extremes of tidal volume and at greater and lesser volumes. Stiffness at L4 and L2 increased above base-level values at functional residual capacity (L2 14.9 N/mm and L4 15.3 N/mm) with both inspiratory and expiratory efforts. The increase was related to the respiratory effort and was greatest during maximum expiration (L2 24.9 N/mm and L4 23.9 N/mm). The results indicate that changes in trunk muscle activity and IAP with respiratory efforts modulate spinal stiffness. In addition, the diaphragm may augment spinal stiffness via attachment of its crural fibers to the lumbar vertebrae. PMID:12970374

  16. Nonparticipatory Stiffness in the Male Perioral Complex

    ERIC Educational Resources Information Center

    Chu, Shin-Ying; Barlow, Steven M.; Lee, Jaehoon

    2009-01-01

    Purpose: The objective of this study was to extend previous published findings in the authors' laboratory using a new automated technology to quantitatively characterize nonparticipatory perioral stiffness in healthy male adults. Method: Quantitative measures of perioral stiffness were sampled during a nonparticipatory task using a…

  17. Relative stiffness of flat-conductor cable

    NASA Technical Reports Server (NTRS)

    Hankins, J. D.

    1977-01-01

    Bending moment data were taken on ten different cable samples and normalized to express all stiffness factors in terms of cable 5.1 cm in width. Relative stiffness data and nominal physical characteristics are tabulated and presented in graphical form for designers who may be interested in finding torques exerted on critical components by short lengths of cable.

  18. Identification of dynamic force coefficients of a labyrinth and gas damper seal using impact load excitations 

    E-print Network

    Ransom, David Lawrence

    1997-01-01

    Experiments to identify stiffness and damping force coefficients of a two bladed teeth-on-stator labyrinth seal and a gas damper seal, both of diverging clearance, are presented. Calibrated impact guns excite a housing holding the test seal...

  19. Rolling Element Bearing Stiffness Matrix Determination (Presentation)

    SciTech Connect

    Guo, Y.; Parker, R.

    2014-01-01

    Current theoretical bearing models differ in their stiffness estimates because of different model assumptions. In this study, a finite element/contact mechanics model is developed for rolling element bearings with the focus of obtaining accurate bearing stiffness for a wide range of bearing types and parameters. A combined surface integral and finite element method is used to solve for the contact mechanics between the rolling elements and races. This model captures the time-dependent characteristics of the bearing contact due to the orbital motion of the rolling elements. A numerical method is developed to determine the full bearing stiffness matrix corresponding to two radial, one axial, and two angular coordinates; the rotation about the shaft axis is free by design. This proposed stiffness determination method is validated against experiments in the literature and compared to existing analytical models and widely used advanced computational methods. The fully-populated stiffness matrix demonstrates the coupling between bearing radial, axial, and tilting bearing deflections.

  20. Spontaneous wrinkle branching by gradient stiffness

    NASA Astrophysics Data System (ADS)

    Ni, Yong; Yang, Dong; He, Linghui

    2012-09-01

    The concept of coherency loss is proposed to understand wrinkle branching as a pathway toward hierarchical wrinkling pattern formation in a compressed film-substrate system with gradient stiffness of the film or substrate. A simple model indicates that the wrinkle branching arises when the characteristic length of the stiffness inhomogeneity zone is larger than the coherency persistent length, which depends on the amplitude of the stiffness inhomogeneity. Numerical simulations of nonlinear wrinkles based on the model of the Föppl-von Kármán plate on compliant substrates show how regulating the size and amplitude of the stiffness inhomogeneities results in branched wrinkles in striking agreement with the existing observations. The paper reveals the origin of such kinds of branched wrinkles and may provide a guideline for controllable hierarchical wrinkles by patterning the stiffness gradient.

  1. Spontaneous wrinkle branching by gradient stiffness.

    PubMed

    Ni, Yong; Yang, Dong; He, Linghui

    2012-09-01

    The concept of coherency loss is proposed to understand wrinkle branching as a pathway toward hierarchical wrinkling pattern formation in a compressed film-substrate system with gradient stiffness of the film or substrate. A simple model indicates that the wrinkle branching arises when the characteristic length of the stiffness inhomogeneity zone is larger than the coherency persistent length, which depends on the amplitude of the stiffness inhomogeneity. Numerical simulations of nonlinear wrinkles based on the model of the Föppl-von Kármán plate on compliant substrates show how regulating the size and amplitude of the stiffness inhomogeneities results in branched wrinkles in striking agreement with the existing observations. The paper reveals the origin of such kinds of branched wrinkles and may provide a guideline for controllable hierarchical wrinkles by patterning the stiffness gradient. PMID:23030926

  2. Stiffness Control of Surgical Continuum Manipulators

    PubMed Central

    Mahvash, Mohsen; Dupont, Pierre E.

    2013-01-01

    This paper introduces the first stiffness controller for continuum robots. The control law is based on an accurate approximation of a continuum robot’s coupled kinematic and static force model. To implement a desired tip stiffness, the controller drives the actuators to positions corresponding to a deflected robot configuration that produces the required tip force for the measured tip position. This approach provides several important advantages. First, it enables the use of robot deflection sensing as a means to both sense and control tip forces. Second, it enables stiffness control to be implemented by modification of existing continuum robot position controllers. The proposed controller is demonstrated experimentally in the context of a concentric tube robot. Results show that the stiffness controller achieves the desired stiffness in steady state, provides good dynamic performance, and exhibits stability during contact transitions. PMID:24273466

  3. What drives the translocation of stiff chains?

    PubMed Central

    Zandi, Roya; Reguera, David; Rudnick, Joseph; Gelbart, William M.

    2003-01-01

    We study the dynamics of the passage of a stiff chain through a pore into a cell containing particles that bind reversibly to it. Using Brownian molecular dynamics simulations we investigate the mean first-passage time as a function of the length of the chain inside for different concentrations of binding particles. As a consequence of the interactions with these particles, the chain experiences a net force along its length whose calculated value from the simulations accounts for the velocity at which it enters the cell. This force can in turn be obtained from the solution of a generalized diffusion equation incorporating an effective Langmuir adsorption free energy for the chain plus binding particles. These results suggest a role of binding particles in the translocation process that is in general quite different from that of a Brownian ratchet. Furthermore, nonequilibrium effects contribute significantly to the dynamics; e.g., the chain often enters the cell faster than particle binding can be saturated, resulting in a force several times smaller than the equilibrium value. PMID:12851462

  4. The difference between stiffness and quasi-stiffness in the context of biomechanical modeling.

    PubMed

    Rouse, Elliott J; Gregg, Robert D; Hargrove, Levi J; Sensinger, Jonathon W

    2013-02-01

    The ankle contributes the majority of mechanical power during walking and is a frequently studied joint in biomechanics. Specifically, researchers have extensively investigated the torque-angle relationship for the ankle during dynamic tasks, such as walking and running. The slope of this relationship has been termed the "quasi-stiffness." However, over time, researchers have begun to interchange the concepts of quasi-stiffness and stiffness. This is an especially important distinction as researchers currently begin to investigate the appropriate control systems for recently developed powered prosthetic legs. The quasi-stiffness and stiffness are distinct concepts in the context of powered joints, and are equivalent in the context of passive joints. The purpose of this paper is to demonstrate the difference between the stiffness and quasi-stiffness using a simple impedance-controlled inverted pendulum model and a more sophisticated biped walking model, each with the ability to modify the trajectory of an impedance controller's equilibrium angle position. In both cases, stiffness values are specified by the controller and the quasi-stiffness are shown during a single step. Both models have widely varying quasi-stiffness but each have a single stiffness value. Therefore, from this simple modeling approach, the differences and similarities between these two concepts are elucidated. PMID:23212310

  5. Model-Based Estimation of Knee Stiffness

    PubMed Central

    Pfeifer, Serge; Vallery, Heike; Hardegger, Michael; Riener, Robert; Perreault, Eric J.

    2013-01-01

    During natural locomotion, the stiffness of the human knee is modulated continuously and subconsciously according to the demands of activity and terrain. Given modern actuator technology, powered transfemoral prostheses could theoretically provide a similar degree of sophistication and function. However, experimentally quantifying knee stiffness modulation during natural gait is challenging. Alternatively, joint stiffness could be estimated in a less disruptive manner using electromyography (EMG) combined with kinetic and kinematic measurements to estimate muscle force, together with models that relate muscle force to stiffness. Here we present the first step in that process, where we develop such an approach and evaluate it in isometric conditions, where experimental measurements are more feasible. Our EMG-guided modeling approach allows us to consider conditions with antagonistic muscle activation, a phenomenon commonly observed in physiological gait. Our validation shows that model-based estimates of knee joint stiffness coincide well with experimental data obtained using conventional perturbation techniques. We conclude that knee stiffness can be accurately estimated in isometric conditions without applying perturbations, which presents an important step towards our ultimate goal of quantifying knee stiffness during gait. PMID:22801482

  6. Physical inactivity and arterial stiffness in COPD

    PubMed Central

    Sievi, Noriane A; Franzen, Daniel; Kohler, Malcolm; Clarenbach, Christian F

    2015-01-01

    Background Arterial stiffness is an important predictor of cardiovascular risk besides classic cardiovascular risk factors. Previous studies showed that arterial stiffness is increased in patients with COPD compared to healthy controls and exercise training may reduce arterial stiffness. Since physical inactivity is frequently observed in patients with COPD and exercise training may improve arterial stiffness, we hypothesized that low daily physical activity may be associated with increased arterial stiffness. Methods In 123 patients with COPD (72% men; mean [standard deviation] age: 62 [7.5] years; median [quartile] forced expiratory volume in 1 second 35 [27/65] %predicted), arterial stiffness was assessed by augmentation index (AI). Daily physical activity level (PAL) was measured by an activity monitor (SenseWear Pro™) >1 week. The association between AI and PAL was investigated by univariate and multivariate regression analysis, taking into account disease-specific characteristics and comorbidities. Results Patients suffered from moderate (35%), severe (32%), and very severe (33%) COPD, and 22% were active smokers. Median (quartile) PAL was 1.4 (1.3/1.5) and mean (standard deviation) AI 26% (9.2%). PAL showed a negative association with AI (B=?9.32, P=0.017) independent of age, sex, blood pressure, and airflow limitation. Conclusion In COPD patients, a higher PAL seems to favorably influence arterial stiffness and therefore may reduce cardiovascular risk. Clinical Trial Registration http://www.ClinicalTrials.gov, NCT01527773 PMID:26392763

  7. Stiff Coatings on Compliant Biofibers

    PubMed Central

    Holten-Andersen, Niels; Zhao, Hua; Waite, J. Herbert

    2009-01-01

    For lasting holdfast attachment, the mussel Mytilus californianus coats its byssal threads with a protective cuticle 2-5 ?m thick that is 4-6 times stiffer than the underlying collagen fibers. Although cuticle hardness (0.1 GPa) and stiffness (2 GPa) resemble those observed in related mussels, a more effective dispersion of microdamage enables M. californianus byssal threads to sustain strains to almost 120% before cuticle rupture occurs. Underlying factors for the superior damage tolerance of the byssal cuticle were explored in its microarchitecture and in the cuticular protein, mcfp-1. Cuticle microstructure was distinctly granular, with granule diameters (?200 nm) only a quarter of those in M. galloprovincialis cuticle, for example. Compared with homologous proteins in related mussel species, mcfp-1 from M. californianus had a similar mass (?92 kDa) and number of tandemly repeated decapeptides, and contained the same post-translational modifications, namely, trans-4-hydroxyproline, trans-2,3-cis-3,4-dihydroxyproline, and 3,4-dihydroxyphenylalanine (Dopa). The prominence of isoleucine in mcfp-1, however, distinguished it from homologues in other species. The complete protein sequence deduced from cDNAs for two related variants revealed a highly conserved consensus decapeptide PKISYPPTYK that is repeated 64 times and differs slightly from the consensus peptide (AKPSYPPTYK) of both M. galloprovincialis and M. edulis proteins. PMID:19220048

  8. Athletic Footwear, Leg Stiffness, and Running Kinematics

    PubMed Central

    Bishop, Mark; Fiolkowski, Paul; Conrad, Bryan; Brunt, Denis; Horodyski, MaryBeth

    2006-01-01

    Context: The leg acts as a linear spring during running and hopping and adapts to the stiffness of the surface, maintaining constant total stiffness of the leg-surface system. Introducing a substance (eg, footwear) may affect the stiffness of the leg in response to changes in surface stiffness. Objective: To determine if the type of athletic footwear affects the regulation of leg stiffness in dynamic activities. Design: Repeated-measures design. Setting: Motion analysis laboratory. Patients or Other Participants: Nine healthy adults (age = 28 ± 6.8 years, mass = 71.6 ± 12.9 kg) free from lower extremity injuries. Intervention(s): Subjects hopped at 2.2 Hz on a forceplate under 3 footwear conditions (barefoot, low-cost footwear, high-cost footwear). Subjects ran on a treadmill at 2 speeds (2.23 m/s, 3.58 m/s) under the same footwear conditions. Main Outcome Measure(s): Limb stiffness was calculated from forceplate data. Kinematic data (knee and ankle angles at initial contact and peak joint excursion after contact) were collected during running. We calculated 1-way repeated-measures (stiffness) and 2-way (speed by footwear) repeated-measures analyses of variance (running kinematics) to test the dependent variables. Results: A significant increase in leg stiffness from the barefoot to the “cushioned” shoe condition was noted during hopping. When running shod, runners landed in more dorsiflexion but had less ankle motion than when running barefoot. No differences were seen between the types of shoes. The primary kinematic difference was identified as running speed increased: runners landed in more knee flexion. At the ankle, barefoot runners increased ankle motion to a significantly greater extent than did shod runners as speed increased. Conclusions: Footwear influences the maintenance of stiffness in the lower extremity during hopping and joint excursion at the ankle in running. Differences in cushioning properties of the shoes tested did not appear to be significant. PMID:17273463

  9. Tectorial membrane. II: Stiffness measurements in vivo.

    PubMed

    Zwislocki, J J; Cefaratti, L K

    1989-11-01

    The tectorial membrane is assumed to play a crucial role in the stimulation of the cochlear hair cells and was thought for decades to serve as a stiff anchor for the tips of the hair-cell stereocilia, particularly those belonging to the OHCs. Yet, its stiffness has never been measured under conditions approximating its normal environment in live animals. We have developed a method for doing this. The tectorial membrane is approached through the lateral wall of scala media. The bony cochlear capsule is removed along scala media over somewhat less than 1/4 turn, and the underlying spiral ligament and stria vascularis are carefully reflected. With the help of a three axial hydraulic manipulator, a flexible micropipette filled with isotonic KCl is inserted into the tectorial membrane at one of two different angles and moved either transversally, away from the basilar membrane, or radially, toward or away from the modiolus. This causes the tectorial membrane to be deformed and the micropipette to bend. The micropipette stiffness is calibrated on an instrument of a new kind, so as to convert the bend into force. The calibration allows us to determine the point stiffness of the tectorial membrane from the amount of micropipette bend. The stiffness of the tectorial membrane per unit length has been calculated from the point stiffness with the help of the deformation pattern. Transversal and radial stiffness magnitudes have been determined in the second cochlear turn in Mongolian gerbils. Both are smaller by almost an order of magnitude than the corresponding aggregate stiffness of the OHC stereocilia. As a consequence, the tectorial membrane cannot act as a stiff anchor for the stereocilia but only as a mass load, except at relatively low sound frequencies where mass effects are negligible. This means that the classical model of shear motion between the tectorial membrane and the reticular lamina must be replaced. PMID:2606804

  10. “Smooth Muscle Cell Stiffness Syndrome”—Revisiting the Structural Basis of Arterial Stiffness

    PubMed Central

    Sehgel, Nancy L.; Vatner, Stephen F.; Meininger, Gerald A.

    2015-01-01

    In recent decades, the pervasiveness of increased arterial stiffness in patients with cardiovascular disease has become increasingly apparent. Though, this phenomenon has been well documented in humans and animal models of disease for well over a century, there has been surprisingly limited development in a deeper mechanistic understanding of arterial stiffness. Much of the historical literature has focused on changes in extracellular matrix proteins—collagen and elastin. However, extracellular matrix changes alone appear insufficient to consistently account for observed changes in vascular stiffness, which we observed in our studies of aortic stiffness in aging monkeys. This led us to examine novel mechanisms operating at the level of the vascular smooth muscle cell (VSMC)—that include increased cell stiffness and adhesion to extracellular matrix—which that may be interrelated with other mechanisms contributing to arterial stiffness. We introduce these observations as a new concept—the Smooth Muscle Cell Stiffness Syndrome (SMCSS)—within the field of arterial stiffness and posit that stiffening of vascular cells impairs vascular function and may contribute stiffening to the vasculature with aging and cardiovascular disease. Importantly, this review article revisits the structural basis of arterial stiffness in light of these novel findings. Such classification of SMCSS and its contextualization into our current understanding of vascular mechanics may be useful in the development of strategic therapeutics to directly target arterial stiffness. PMID:26635621

  11. The viscoelastic stiffness model of seismicity

    NASA Technical Reports Server (NTRS)

    Cohen, S. C.

    1978-01-01

    A viscoelastic stiffness model of seismicity is developed by introducing a viscoelastic element into the stiffness model for fault dynamics. The introduction of this element permits modeling of transient anelastic deformations in response to stress loading and relaxation and provides a mechanism for partial stress recovery following an earthquake. As a consequence, several phenomena not present in elastic stiffness theory emerge. These include postseismic creep, foreshocks, and aftershocks. Numerical simulations of fault motion also reveal episodes of stable sliding, tertiary creep preceeding earthquakes, and long-term aseismic creep.

  12. Study of a piecewise linear dynamic system with negative and positive stiffness

    NASA Astrophysics Data System (ADS)

    Zou, Keguan; Nagarajaiah, Satish

    2015-05-01

    The present paper mainly focuses on numerical and analytical study of a piecewise linear dynamic oscillator with negative stiffness followed by positive stiffness which has not been studied to date. The dynamic system of interest stems from a previous analytical and experimental research on adaptive negative stiffness for the purpose of seismic protection. Numerical algorithms meant specifically for simulating piecewise smooth (PWS) systems like this nonlinear system are studied. An appropriate combination of negative stiffness and adequate damping can reduce the peak restoring or transmitted force with a slightly larger peak displacement. Essentially, the negative stiffness system in a dynamic system is very beneficial in reducing the amount of force transmitted. The exact solution is derived for free vibration. A modified Lindstedt-Poincaré method (modified L-P method) is adopted to derive approximate periodic solutions for the forced and damped system and its frequency-response curves are obtained through numerical simulation. The modified L-P solution obtained for the forced and damped case is found to agree well with the numerical results. In the piecewise linear dynamic system with initial negative stiffness followed by positive stiffness, it is found that the response remains bounded in a limit cycle. This system behaves similar to a van der Pol oscillator wherein negative damping is followed by positive damping. Presented herein is a special case as defined by the specified parameter ranges; thus, to make it more general future work is needed.

  13. Vascular stiffness in insulin resistance and obesity

    PubMed Central

    Jia, Guanghong; Aroor, Annayya R.; DeMarco, Vincent G.; Martinez-Lemus, Luis A.; Meininger, Gerald A.; Sowers, James R.

    2015-01-01

    Obesity, insulin resistance, and type 2 diabetes are associated with a substantially increased prevalence of vascular fibrosis and stiffness, with attendant increased risk of cardiovascular and chronic kidney disease. Although the underlying mechanisms and mediators of vascular stiffness are not well understood, accumulating evidence supports the role of metabolic and immune dysregulation related to increased adiposity, activation of the renin angiotensin aldosterone system, reduced bioavailable nitric oxide, increased vascular extracellular matrix (ECM) and ECM remodeling in the pathogenesis of vascular stiffness. This review will give a brief overview of the relationship between obesity, insulin resistance and increased vascular stiffness to provide a contemporary understanding of the proposed underlying mechanisms and potential therapeutic strategies. PMID:26321962

  14. 49 CFR 213.359 - Track stiffness.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 2011-10-01 2011-10-01 false Track stiffness. 213.359 Section 213.359...ADMINISTRATION, DEPARTMENT OF TRANSPORTATION TRACK SAFETY STANDARDS Train Operations at Track Classes 6 and Higher § 213.359 Track...

  15. 49 CFR 213.359 - Track stiffness.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 2010-10-01 2010-10-01 false Track stiffness. 213.359 Section 213.359...ADMINISTRATION, DEPARTMENT OF TRANSPORTATION TRACK SAFETY STANDARDS Train Operations at Track Classes 6 and Higher § 213.359 Track...

  16. Programmable variable stiffness 2D surface design

    NASA Astrophysics Data System (ADS)

    Trabia, Sarah; Hwang, Taeseon; Yim, Woosoon

    2014-03-01

    Variable stiffness features can contribute to many engineering applications ranging from robotic joints to shock and vibration mitigation. In addition, variable stiffness can be used in the tactile feedback to provide the sense of touch to the user. A key component in the proposed device is the Biased Magnetorheological Elastomer (B-MRE) where iron particles within the elastomer compound develop a dipole interaction energy. A novel feature of this device is to introduce a field induced shear modulus bias via a permanent magnet which provides an offset with a current input to the electromagnetic control coil to change the compliance or modulus of a base elastomer in both directions (softer or harder). The B-MRE units can lead to the design of a variable stiffness surface. In this preliminary work, both computational and experimental results of the B-MRE are presented along with a preliminary design of the programmable variable stiffness surface design.

  17. An analysis of traction drive torsional stiffness

    NASA Technical Reports Server (NTRS)

    Rohn, D. A.; Loewenthal, S. H.

    1983-01-01

    The tangential compliance of elastic bodies in concentrated contact applied to traction drive elements to determine their torsional stiffness was analyzed. Static loading and rotating conditions are considered. The effects of several design variables are shown. The theoretical torsional stiffness of a fixed ratio multiroller drive is computed and compared to experimental values. It is shown that the torsional compliance of the traction contacts themselves is a relatively small portion of the overall drive system compliance.

  18. Exercise, Vascular Stiffness, and Tissue Transglutaminase

    PubMed Central

    Steppan, Jochen; Sikka, Gautam; Jandu, Simran; Barodka, Viachaslau; Halushka, Marc K.; Flavahan, Nicholas A.; Belkin, Alexey M.; Nyhan, Daniel; Butlin, Mark; Avolio, Alberto; Berkowitz, Dan E.; Santhanam, Lakshmi

    2014-01-01

    Background Vascular aging is closely associated with increased vascular stiffness. It has recently been demonstrated that decreased nitric oxide (NO)?induced S?nitrosylation of tissue transglutaminase (TG2) contributes to age?related vascular stiffness. In the current study, we tested the hypothesis that exercise restores NO signaling and attenuates vascular stiffness by decreasing TG2 activity and cross?linking in an aging rat model. Methods and Results Rats were subjected to 12 weeks of moderate aerobic exercise. Aging was associated with diminished phosphorylated endothelial nitric oxide synthase and phosphorylated vasodilator?stimulated phosphoprotein abundance, suggesting reduced NO signaling. TG2 cross?linking activity was significantly increased in old animals, whereas TG2 abundance remained unchanged. These alterations were attenuated in the exercise cohort. Simultaneous measurement of blood pressure and pulse wave velocity (PWV) demonstrated increased aortic stiffness in old rats, compared to young, at all values of mean arterial pressure (MAP). The PWV?MAP correlation in the old sedentary and old exercise cohorts was similar. Tensile testing of the vessels showed increased stiffness of the aorta in the old phenotype with a modest restoration of mechanical properties toward the young phenotype with exercise. Conclusions Increased vascular stiffness during aging is associated with decreased TG2 S?nitrosylation, increased TG2 cross?linking activity, and increased vascular stiffness likely the result of decreased NO bioavailability. In this study, a brief period of moderate aerobic exercise enhanced NO signaling, attenuated TG cross?linking activity, and reduced ex vivo tensile properties, but failed to reverse functional vascular stiffness in vivo, as measured by PWV. PMID:24721796

  19. Lipoprotein(a) and Arterial Stiffness Parameters

    PubMed Central

    Sorokin, Alexander; Kotani, Kazuhiko

    2015-01-01

    Background Circulating lipoprotein(a) [Lp(a)] and arterial stiffness are markers associated with the atherosclerotic processes. With regard to cardiovascular outcomes, the relationship between Lp(a) and arterial stiffness has not been sufficiently summarized. The present review focuses on the existing association between Lp(a) and arterial stiffness parameters. Summary This review included human clinical studies that were published between 1980 and 2015. The metrics of arterial stiffness parameters, ‘pulse wave velocity’ (PWV) and ‘cardio-ankle vascular index’ (CAVI), were used for this search, which yielded only 4 cross-sectional studies on this topic. Of these 4 studies, 3 reports were based on the use of PWV, while 1 study was based on the use of CAVI. Three studies (including the study using CAVI) reported that high Lp(a) levels were positively associated with arterial stiffness. Conclusion The present review indicates a positive association between Lp(a) and arterial stiffness, as assessed by PWV and CAVI. To definitively establish these findings, there is a need for further prospective outcome studies that simultaneously measure Lp(a) and the oxidative form of Lp(a) (as a pathological marker) as well as PWV and CAVI.

  20. Longitudinal relaxation of initially straight flexible and stiff polymers

    NASA Astrophysics Data System (ADS)

    Dimitrakopoulos, Panagiotis; Dissanayake, Inuka

    2004-11-01

    The present talk considers the relaxation of a single flexible or stiff polymer chain from an initial straight configuration in a viscous solvent. This problem commonly arises when strong flows are turned off in both industrial and biological applications. The problem is also motivated by recent experiments with single biopolymer molecules relaxing after being fully extended by applied forces as well as by the recent development of micro-devices involving stretched tethered biopolymers. Our results are applicable to a wide array of synthetic polymers such as polyacrylamides, Kevlar and polyesters as well as biopolymers such as DNA, actin filaments, microtubules and MTV. In this talk we discuss the mechanism of the polymer relaxation as was revealed through Brownian Dynamics simulations covering a broad range of time scales and chain stiffness. After the short-time free diffusion, the chain's longitudinal reduction at early intermediate times is shown to constitute a universal behavior for any chain stiffness caused by a quasi-steady relaxation of tensions associated with the deforming action of the Brownian forces. Stiff chains are shown to exhibit a late intermediate-time longitudinal reduction associated with a relaxation of tensions affected by the deforming Brownian and the restoring bending forces. The longitudinal and transverse relaxations are shown to obey different laws, i.e. the chain relaxation is anisotropic at all times. In the talk, we show how from the knowledge of the relaxation mechanism, we can predict and explain the polymer properties including the polymer stress and the solution birefringence. In addition, a generalized stress-optic law is derived valid for any time and chain stiffness. All polymer properties which depend on the polymer length are shown to exhibit two intermediate-time behaviors with the early one to constitute a universal behavior for any chain stiffness. This work was supported in part by the Minta Martin Research Fund. The computations were performed on multiprocessor computers provided by the National Center for Supercomputing Applications (NCSA) in Illinois (grant DMR000003), and by an Academic Equipment Grant from Sun Microsystems Inc.

  1. Design of a variable-stiffness robotic hand using pneumatic soft rubber actuators

    NASA Astrophysics Data System (ADS)

    Nagase, Jun-ya; Wakimoto, Shuichi; Satoh, Toshiyuki; Saga, Norihiko; Suzumori, Koichi

    2011-10-01

    In recent years, Japanese society has been ageing, engendering a labor shortage of young workers. Robots are therefore expected to be useful in performing tasks such as day-to-day support for elderly people. In particular, robots that are intended for use in the field of medical care and welfare are expected to be safe when operating in a human environment because they often come into contact with people. Furthermore, robots must perform various tasks such as regrasping, grasping of soft objects, and tasks using frictional force. Given these demands and circumstances, a tendon-driven robot hand with a stiffness changing finger has been developed. The finger surface stiffness can be altered by adjusting the input pressure depending on the task. Additionally, the coefficient of static friction can be altered by changing the surface stiffness merely by adjusting the input air pressure. This report describes the basic structure, driving mechanism, and basic properties of the proposed robot hand.

  2. Conformational Analysis of Stiff Chiral Polymers with End-Constraints

    PubMed Central

    Kim, Jin Seob; Chirikjian, Gregory S.

    2010-01-01

    We present a Lie-group-theoretic method for the kinematic and dynamic analysis of chiral semi-flexible polymers with end constraints. The first is to determine the minimum energy conformations of semi-flexible polymers with end constraints, and the second is to perform normal mode analysis based on the determined minimum energy conformations. In this paper, we use concepts from the theory of Lie groups and principles of variational calculus to model such polymers as inextensible or extensible chiral elastic rods with coupling between twisting and bending stiffnesses, and/or between twisting and extension stiffnesses. This method is general enough to include any stiffness and chirality parameters in the context of elastic filament models with the quadratic elastic potential energy function. As an application of this formulation, the analysis of DNA conformations is discussed. We demonstrate our method with examples of DNA conformations in which topological properties such as writhe, twist, and linking number are calculated from the results of the proposed method. Given these minimum energy conformations, we describe how to perform the normal mode analysis. The results presented here build both on recent experimental work in which DNA mechanical properties have been measured, and theoretical work in which the mechanics of non-chiral elastic rods has been studied. PMID:20198114

  3. Empirical Investigations A Stiffness Discrimination Experiment Including Analysis of Palpation

    E-print Network

    Williams II, Robert L.

    stiffness discrimination between multiple objects. (Sim Healthcare 5:000­000, 2010) Key Words: StiffnessEmpirical Investigations A Stiffness Discrimination Experiment Including Analysis of Palpation discrimination program to train and test users in finding subtle differences in human tissue stiffness

  4. Assessments of endothelial function and arterial stiffness are reproducible in patients with COPD

    PubMed Central

    Rodriguez-Miguelez, Paula; Seigler, Nichole; Bass, Leon; Dillard, Thomas A; Harris, Ryan A

    2015-01-01

    Background Elevated cardiovascular disease risk is observed in patients with COPD. Non-invasive assessments of endothelial dysfunction and arterial stiffness have recently emerged to provide mechanistic insight into cardiovascular disease risk in COPD; however, the reproducibility of endothelial function and arterial stiffness has yet to be investigated in this patient population. Objectives This study sought to examine the within-day and between-day reproducibility of endothelial function and arterial stiffness in patients with COPD. Methods Baseline diameter, peak diameter, flow-mediated dilation, augmentation index, augmentation index at 75 beats per minute, and pulse wave velocity were assessed three times in 17 patients with COPD (six males, eleven females, age range 47–75 years old; forced expiratory volume in 1 second =51.5% predicted). Session A and B were separated by 3 hours (within-day), whereas session C was conducted at least 7 days following session B (between-day). Reproducibility was assessed by: 1) paired t-tests, 2) coefficients of variation, 3) coefficients of variation prime, 4) intra-class correlation coefficient, 5) Pearson’s correlations (r), and 6) Bland–Altman plots. Five acceptable assessments were required to confirm reproducibility. Results Six out of six within-day criteria were met for endothelial function and arterial stiffness outcomes. Six out of six between-day criteria were met for baseline and peak diameter, augmentation index and pulse wave velocity, whereas five out of six criteria were met for flow-mediated dilation. Conclusion The present study provides evidence for within-day and between-day reproducibility of endothelial function and arterial stiffness in patients with COPD. PMID:26396509

  5. Ultrasonic measurements of stiffness in thermal-mechanically fatigued IM7/5260 composites

    SciTech Connect

    Seale, M.D.; Madaras, E.I. )

    1999-08-01

    In recent years, ultrasonic methods have been developed that can measure the mechanical stiffness of composites. The Lamb wave velocity is directly related to the material parameters, so an effective method exists to ascertain the stiffness of composites by measuring the velocity of these waves. In this study, a Lamb wave measurement system was used to measure the bending and out-of-plane stiffness coefficients of thermoset composite laminates undergoing thermal-mechanical loading. A series of 16 ply and 32 ply composite laminates were subjected to thermal-mechanical fatigue (TMF) in load frames equipped with special environmental chambers. The composite system studied was a graphite fiber-reinforced bismaleimide thermoset, IM7/5260. The samples were subjected to both high and low temperature profiles as well as high-strain and low-strain profiles. The bending and out-of-plane stiffnesses for composite samples that have undergone over 6,000 cycles of combined thermal and mechanical fatigue are reported. The Lamb wave generated elastic stiffness results have shown decreases of up to 64% at 4,706 cycles for samples subjected to TMF at high temperatures and less than a 10% decrease at over 6,000 cycles for samples subjected to TMF at low temperatures.

  6. A novel magnetorheological elastomer isolator with negative changing stiffness for vibration reduction

    NASA Astrophysics Data System (ADS)

    Yang, J.; Sun, S. S.; Du, H.; Li, W. H.; Alici, G.; Deng, H. X.

    2014-10-01

    Magneto-rheological elastomers (MREs) have attracted notable credits in the development of smart isolators and absorbers due to their controllable stiffness and damping properties. For the purpose of mitigating unwanted structural and/or machinery vibrations, the traditional MRE-based isolators have been generally proven effective because the MR effect can increase the stiffness when the magnetic field is strengthened. This study presents a novel MRE isolator that experienced reduced stiffness when the applied current was increased. This innovative work was accomplished by applying a hybrid magnet (electromagnet and permanent magnets) onto a multilayered MRE structure. To characterise this negative changing stiffness concept, a multilayered MRE isolator with a hybrid magnet was first designed, fabricated and then tested to measure its properties. An obvious reduction of the effective stiffness and natural frequency of the proposed MRE isolator occurred when the current was continuously adjusted. This device could also work as a conventional MRE isolator as its effective stiffness and natural frequency also increased when a negative current was applied. Further testing was carried out on a one-degree-of-freedom system to assess how effectively this device could isolate vibration. In this experiment, two cases were considered; in each case, the vibration of the primary system was obviously attenuated under ON-OFF control logic, thus demonstrating the feasibility of this novel design as an alternative adaptive vibration isolator.

  7. Nanoscale directional motion towards regions of stiffness.

    PubMed

    Chang, Tienchong; Zhang, Hongwei; Guo, Zhengrong; Guo, Xingming; Gao, Huajian

    2015-01-01

    How to induce nanoscale directional motion via some intrinsic mechanisms pertaining to a nanosystem remains a challenge in nanotechnology. Here we show via molecular dynamics simulations that there exists a fundamental driving force for a nanoscale object to move from a region of lower stiffness toward one of higher stiffness on a substrate. Such nanoscale directional motion is induced by the difference in effective van der Waals potential energy due to the variation in stiffness of the substrate; i.e., all other conditions being equal, a nanoscale object on a stiffer substrate has lower van der Waals potential energy. This fundamental law of nanoscale directional motion could lead to promising routes for nanoscale actuation and energy conversion. PMID:25615480

  8. Comparison of surgical outcome in impingement syndrome with and without stiff shoulder

    PubMed Central

    Park, Jin-Young; Pandher, Dilbans Singh; Moon, Gi-Hyuk; Yoo, Moon-Jib; Lee, Sung Tae

    2008-01-01

    Background: In impingment syndrome with associated stiff shoulder the general protocol of management is to conservatively treat the stiff shoulder followed by operative treatment of the impingement syndrome. This consecutive prospective study was carried out to evaluate the functional outcome of surgical management for impingement syndrome associated with stiff shoulder and to compare the results with surgical management of impingement syndrome alone. Materials and Methods: We evaluated a total of 100 patients with impingement syndrome, consisting of 76 patients with impingement syndrome alone (Group A) and 24 patients of stiff shoulder associated with impingement syndrome (Group B). Group A patients were treated by subacromial decompression alone and Group B patients were treated by closed manipulation under anesthesia followed by subacromial decompression. Results: According to the American Shoulder and Elbow Surgeons (ASES) evaluation score satisfactory results were obtained in 80% patients of Group A and 67% patients of Group B, while for patients with diabetes [(n = 18), Group A (n = 11), Group B (n = 7)] satisfactory results were achieved in 82% of patients of Group A(9/11) and 43% of Group B(3/7). Overall, Group B patients had a lower range of motion for external rotation postoperatively, thus indicating that procedures to improve the external rotation, such as a release of the rotator interval or anterior capsule, might be considered in conjunction with other surgical procedures in patients with impingement syndrome with associated stiffness to further improve functional outcome. Conclusion: Acromioplasty can be performed in stiff shoulder associated with impingement syndrome without fears of further worsening of stiffness from adhesions with the exposed raw undersurface of acromian. Patients with diabetes mellitus and shoulder stiffness tend to have poor clinical outcomes and must receive appropriate counseling preoperatively. PMID:19826525

  9. Meta-Analysis of Coefficient Alpha

    ERIC Educational Resources Information Center

    Rodriguez, Michael C.; Maeda, Yukiko

    2006-01-01

    The meta-analysis of coefficient alpha across many studies is becoming more common in psychology by a methodology labeled reliability generalization. Existing reliability generalization studies have not used the sampling distribution of coefficient alpha for precision weighting and other common meta-analytic procedures. A framework is provided for…

  10. The compressive stiffness of human pediatric heads.

    PubMed

    Loyd, Andre Matthew; Nightingale, Roger W; Luck, Jason F; Song, Yin; Fronheiser, Lucy; Cutcliffe, Hattie; Myers, Barry S; Dale Bass, Cameron R

    2015-11-01

    Head injury is a persistent and costly problem for both children and adults. Globally, approximately 10 million people are hospitalized each year for head injuries. Knowing the structural properties of the head is important for modeling the response of the head in impact, and for providing insights into mechanisms of head injury. Hence, the goal of this study was to measure the sub-injurious structural stiffness of whole pediatric heads. 12 cadaveric pediatric (20-week-gestation to 16 years old) heads were tested in a battery of viscoelastic compression tests. The heads were compressed in both the lateral and anterior-posterior directions to 5% of gauge length at normalized deformation rates of 0.0005/s, 0.01/s, 0.1/s, and 0.3/s. Because of the non-linear nature of the response, linear regression models were used to calculate toe region (<2.5%) and elastic region (>2.5%) stiffness separately so that meaningful comparisons could be made across rate, age, and direction. The results showed that age was the dominant factor in predicting the structural stiffness of the human head. A large and statistically significant increase in the stiffness of both the toe region and the elastic region was observed with increasing age (p<0.0001), but no significant difference was seen across direction or normalized deformation rate. The stiffness of the elastic region increased from as low as 5N/mm in the neonate to >4500N/mm in the 16 year old. The changes in stiffness with age may be attributed to the disappearance of soft sutures and the thickening of skull bones with age. PMID:26476760

  11. Running with a load increases leg stiffness.

    PubMed

    Silder, Amy; Besier, Thor; Delp, Scott L

    2015-04-13

    Spring-mass models have been used to characterize running mechanics and leg stiffness in a variety of conditions, yet it remains unknown how running while carrying a load affects running mechanics and leg stiffness. The purpose of this study was to test the hypothesis that running with a load increases leg stiffness. Twenty-seven subjects ran at a constant speed on a force-measuring treadmill while carrying no load, and while wearing weight vests loaded with 10%, 20%, and 30% of body weight. We measured lower extremity motion and created a scaled musculoskeletal model of each subject, which we used to estimate lower extremity joint angles and leg length. We estimated dimensionless leg stiffness as the ratio of the peak vertical ground reaction force (normalized to body weight) and the change in stance phase leg length (normalized to leg length at initial foot contact). Leg length was calculated as the distance from the center of the pelvis to the center-of-pressure under the foot. We found that dimensionless leg stiffness increased when running with load (p=0.001); this resulted from an increase in the peak vertical ground reaction force (p<0.001) and a smaller change in stance phase leg length (p=0.025). When running with load, subjects had longer ground contact times (p<0.020), greater hip (p<0.001) and knee flexion (p=0.048) at the time of initial foot contact, and greater peak stance phase hip, knee, and ankle flexion (p<0.05). Our results reveal that subjects run in a more crouched posture and with higher leg stiffness to accommodate an added load. PMID:25728581

  12. Elastic stiffness of a Skyrmion crystal.

    PubMed

    Nii, Y; Kikkawa, A; Taguchi, Y; Tokura, Y; Iwasa, Y

    2014-12-31

    We observe the elastic stiffness and ultrasonic absorption of a Skyrmion crystal in the chiral-lattice magnet MnSi. The Skyrmion crystal lattice exhibits a stiffness 3 orders of magnitude smaller than that of the atomic lattice of MnSi, being as soft as the flux line lattice in type-II superconductors. The observed anisotropic elastic responses are consistent with the cylindrical shape of the Skyrmion spin texture. Phenomenological analysis reveals that the spin-orbit coupling is responsible for the emergence of anisotropic elasticity in the Skyrmion lattice. PMID:25615379

  13. Factor Scores, Structure Coefficients, and Communality Coefficients

    ERIC Educational Resources Information Center

    Goodwyn, Fara

    2012-01-01

    This paper presents heuristic explanations of factor scores, structure coefficients, and communality coefficients. Common misconceptions regarding these topics are clarified. In addition, (a) the regression (b) Bartlett, (c) Anderson-Rubin, and (d) Thompson methods for calculating factor scores are reviewed. Syntax necessary to execute all four…

  14. Steel Rack Connections: Identification of Most Influential Factors and a Comparison of Stiffness Design Methods.

    PubMed

    Shah, S N R; Sulong, N H Ramli; Shariati, Mahdi; Jumaat, M Z

    2015-01-01

    Steel pallet rack (SPR) beam-to-column connections (BCCs) are largely responsible to avoid the sway failure of frames in the down-aisle direction. The overall geometry of beam end connectors commercially used in SPR BCCs is different and does not allow a generalized analytic approach for all types of beam end connectors; however, identifying the effects of the configuration, profile and sizes of the connection components could be the suitable approach for the practical design engineers in order to predict the generalized behavior of any SPR BCC. This paper describes the experimental behavior of SPR BCCs tested using a double cantilever test set-up. Eight sets of specimens were identified based on the variation in column thickness, beam depth and number of tabs in the beam end connector in order to investigate the most influential factors affecting the connection performance. Four tests were repeatedly performed for each set to bring uniformity to the results taking the total number of tests to thirty-two. The moment-rotation (M-?) behavior, load-strain relationship, major failure modes and the influence of selected parameters on connection performance were investigated. A comparative study to calculate the connection stiffness was carried out using the initial stiffness method, the slope to half-ultimate moment method and the equal area method. In order to find out the more appropriate method, the mean stiffness of all the tested connections and the variance in values of mean stiffness according to all three methods were calculated. The calculation of connection stiffness by means of the initial stiffness method is considered to overestimate the values when compared to the other two methods. The equal area method provided more consistent values of stiffness and lowest variance in the data set as compared to the other two methods. PMID:26452047

  15. Steel Rack Connections: Identification of Most Influential Factors and a Comparison of Stiffness Design Methods

    PubMed Central

    Shah, S. N. R.; Sulong, N. H. Ramli; Shariati, Mahdi; Jumaat, M. Z.

    2015-01-01

    Steel pallet rack (SPR) beam-to-column connections (BCCs) are largely responsible to avoid the sway failure of frames in the down-aisle direction. The overall geometry of beam end connectors commercially used in SPR BCCs is different and does not allow a generalized analytic approach for all types of beam end connectors; however, identifying the effects of the configuration, profile and sizes of the connection components could be the suitable approach for the practical design engineers in order to predict the generalized behavior of any SPR BCC. This paper describes the experimental behavior of SPR BCCs tested using a double cantilever test set-up. Eight sets of specimens were identified based on the variation in column thickness, beam depth and number of tabs in the beam end connector in order to investigate the most influential factors affecting the connection performance. Four tests were repeatedly performed for each set to bring uniformity to the results taking the total number of tests to thirty-two. The moment-rotation (M-?) behavior, load-strain relationship, major failure modes and the influence of selected parameters on connection performance were investigated. A comparative study to calculate the connection stiffness was carried out using the initial stiffness method, the slope to half-ultimate moment method and the equal area method. In order to find out the more appropriate method, the mean stiffness of all the tested connections and the variance in values of mean stiffness according to all three methods were calculated. The calculation of connection stiffness by means of the initial stiffness method is considered to overestimate the values when compared to the other two methods. The equal area method provided more consistent values of stiffness and lowest variance in the data set as compared to the other two methods. PMID:26452047

  16. Nonstrict inequality for Schmidt coefficients of three-qubit states

    NASA Astrophysics Data System (ADS)

    Tamaryan, Levon

    2013-10-01

    Generalized Schmidt decomposition of pure three-qubit states has four positive and one complex coefficients. In contrast to the bipartite case, they are not arbitrary and the largest Schmidt coefficient restricts severely other coefficients. We derive a nonstrict inequality between three-qubit Schmidt coefficients, where the largest coefficient defines the least upper bound for the three nondiagonal coefficients or, equivalently, the three nondiagonal coefficients together define the greatest lower bound for the largest coefficient. In addition, we show the existence of another inequality which should establish an upper bound for the remaining Schmidt coefficient.

  17. Exploiting Variable Stiffness in Explosive Movement Tasks

    E-print Network

    Vijayakumar, Sethu

    Exploiting Variable Stiffness in Explosive Movement Tasks David J. Braun, Matthew Howard and Sethu actuation is advantageous to robot control once high-performance, explosive tasks, such as throwing, hitting highly dynamic, explosive movements. Such movements are characterised by a large release of energy over

  18. [Anaesthetic management of Stiff Man syndrome].

    PubMed

    Marín, T; Hernando, D; Kinast, N; Churruca, I; Sabate, S

    2015-04-01

    Stiff Man syndrome or stiff-person syndrome is a rare autoimmune disorder. It is characterized by increased axial muscular tone and limb musculature, and painful spasms triggered by stimulus. The case is presented of a 44-year-old man with stiff-person syndrome undergoing an injection of botulinum toxin in the urethral sphincter under sedation. Before induction, all the surgical team were ready in order to minimise the anaesthetic time. The patient was monitored by continuous ECG, SpO2 and non-invasive blood pressure. He was induced with fractional dose of propofol 150 mg, fentanyl 50 ?g and midazolam 1mg. Despite careful titration, the patient had an O2 saturation level of 90%,which was resolved by manual ventilation. There was no muscle rigidity or spasm during the operation. Post-operative recovery was uneventful and the patient was discharged 2 days later. A review of other cases is presented. The anaesthetic concern in patients with stiff-person syndrome is the interaction between the anaesthetic agents, the preoperative medication, and the GABA system. For a safe anaesthetic management, total intravenous anaesthesia is recommended instead of inhalation anaesthetics, as well as the close monitoring of the respiratory function and the application of the electrical nerve stimulator when neuromuscular blockers are used. PMID:25060949

  19. Airfoil design: Finding the balance between design lift and structural stiffness

    NASA Astrophysics Data System (ADS)

    Bak, Christian; Gaudern, Nicholas; Zahle, Frederik; Vronsky, Tomas

    2014-06-01

    When upscaling wind turbine blades there is an increasing need for high levels of structural efficiency. In this paper the relationships between the aerodynamic characteristics; design lift and lift-drag ratio; and the structural characteristics were investigated. Using a unified optimization setup, airfoils were designed with relative thicknesses between 18% and 36%, a structural box height of 85% of the relative thickness, and varying box widths in chordwise direction between 20% and 40% of the chord length. The results from these airfoil designs showed that for a given flapwise stiffness, the design lift coefficient increases if the box length reduces and at the same time the relative thickness increases. Even though the conclusions are specific to the airfoil design approach used, the study indicated that an increased design lift required slightly higher relative thickness compared to airfoils with lower design lift to maintain the flapwise stiffness. Also, the study indicated that the lift-drag ratio as a function of flapwise stiffness was relatively independent of the airfoil design with a tendency that the lift-drag ratio decreased for large box lengths. The above conclusions were supported by an analysis of the three airfoil families Riso-C2, DU and FFA, where the lift-drag ratio as a function of flapwise stiffness was decreasing, but relatively independent of the airfoil design, and the design lift coefficient was varying depending on the design philosophy. To make the analysis complete also design lift and lift- drag ratio as a function of edgewise and torsional stiffness were shown.

  20. Stiffness modeling of compliant parallel mechanisms and applications in the performance analysis of a decoupled parallel compliant stage

    NASA Astrophysics Data System (ADS)

    Jiang, Yao; Li, Tie-Min; Wang, Li-Ping

    2015-09-01

    This paper investigates the stiffness modeling of compliant parallel mechanism (CPM) based on the matrix method. First, the general compliance matrix of a serial flexure chain is derived. The stiffness modeling of CPMs is next discussed in detail, considering the relative positions of the applied load and the selected displacement output point. The derived stiffness models have simple and explicit forms, and the input, output, and coupling stiffness matrices of the CPM can easily be obtained. The proposed analytical model is applied to the stiffness modeling and performance analysis of an XY parallel compliant stage with input and output decoupling characteristics. Then, the key geometrical parameters of the stage are optimized to obtain the minimum input decoupling degree. Finally, a prototype of the compliant stage is developed and its input axial stiffness, coupling characteristics, positioning resolution, and circular contouring performance are tested. The results demonstrate the excellent performance of the compliant stage and verify the effectiveness of the proposed theoretical model. The general stiffness models provided in this paper will be helpful for performance analysis, especially in determining coupling characteristics, and the structure optimization of the CPM.

  1. Lamb Wave Stiffness Characterization of Composites Undergoing Thermal-Mechanical Aging

    NASA Technical Reports Server (NTRS)

    Seale, Michael D.; Madaras, Eric I.

    2004-01-01

    The introduction of new, advanced composite materials into aviation systems requires a thorough understanding of the long term effects of combined thermal and mechanical loading upon those materials. Analytical methods investigating the effects of intense thermal heating combined with mechanical loading have been investigated. The damage mechanisms and fatigue lives were dependent on test parameters as well as stress levels. Castelli, et al. identified matrix dominated failure modes for out-of-phase cycling and fiber dominated damage modes for in-phase cycling. In recent years, ultrasonic methods have been developed that can measure the mechanical stiffness of composites. To help evaluate the effect of aging, a suitably designed Lamb wave measurement system is being used to obtain bending and out-of-plane stiffness coefficients of composite laminates undergoing thermal-mechanical loading. The system works by exciting an antisymmetric Lamb wave and calculating the velocity at each frequency from the known transducer separation and the measured time-of-flight. The same peak in the waveforms received at various distances is used to measure the time difference between the signals. The velocity measurements are accurate and repeatable to within 1% resulting in reconstructed stiffness values repeatable to within 4%. Given the material density and plate thickness, the bending and out-of-plane shear stiffnesses are calculated from a reconstruction of the dispersion curve. A mechanical scanner is used to move the sensors over the surface to map the time-of-flight, velocity, or stiffnesses of the entire specimen. Access to only one side of the material is required and no immersion or couplants are required because the sensors are dry coupled to the surface of the plate. In this study, the elastic stiffnesses D(sub 11), D(sub 22), A(sub 44), and A(sub 55) as well as time-of-flight measurements for composite samples that have undergone combined thermal and mechanical aging for a duration of 10,000 hours are reported.

  2. Design and characterization of tunable stiffness flexural bearings

    E-print Network

    Ramirez, Aaron Eduardo

    2012-01-01

    Compressed flexures have a downwards-tunable stiffness in their compliant directions; their stiffness can theoretically be reduced by up to four orders of magnitude. The compression-stiffiness relation is linear for most ...

  3. Prognostic Significance of Regional Arterial Stiffness for Stroke in Hypertension

    PubMed Central

    Kubozono, Takuro; Ohishi, Mitsuru

    2015-01-01

    Background Hypertension is strongly associated with cardiovascular disease. It has been reported that arterial stiffness is related to cardiovascular mortality and morbidity in hypertensive patients and that the physiological evaluation of arterial stiffness may assist clinicians in the early detection of atherosclerosis. Summary It has been demonstrated that increased arterial stiffness is an independent predictor of cardiovascular disease, including stroke. Arterial stiffness is associated with structural changes in the brain. However, the stiffness responses of muscular arteries are different from those of elastic arteries, and so the impact of arterial stiffness and the conclusions to be drawn may be different depending on the region in which the measurement is taken. Key Messages In this review, we summarize the current literature describing the association between arterial stiffness, including carotid-femoral and brachial-ankle pulse wave velocity and cardio-ankle vascular index, and cardiovascular disease, specifically stroke. We discuss the utility and prognostic significance of regional arterial stiffness measurements.

  4. Hepatic and Splenic Stiffness Augmentation Assessed with MR Elastography in an in vivo Porcine Portal Hypertension Model

    PubMed Central

    Yin, Meng; Kolipaka, Arunark; Woodrum, David A.; Glaser, Kevin J.; Romano, Anthony J; Manduca, Armando; Talwalkar, Jayant A.; Araoz, Philip A.; McGee, Kiaran P.; Anavekar, Nandan S.; Ehman, Richard L.

    2013-01-01

    Purpose To investigate the influence of portal pressure on the shear stiffness of the liver and spleen in a well-controlled in vivo porcine model with MR Elastography (MRE). A significant correlation between portal pressure and tissue stiffness could be used to noninvasively assess increased portal venous pressure (portal hypertension), which is a frequent clinical condition caused by cirrhosis of the liver and is responsible for the development of many lethal complications. Materials and Methods During multiple intra-arterial infusions of Dextran-40 in three adult domestic pigs in vivo, 3-D abdominal MRE was performed with left ventricle and portal catheters measuring blood pressure simultaneously. Least-squares linear regressions were used to analyze the relationship between tissue stiffness and portal pressure. Results Liver and spleen stiffness have a dynamic component that increases significantly following an increase in portal or left ventricular pressure. Correlation coefficients with the linear regressions between stiffness and pressure exceeded 0.8 in most cases. Conclusion The observed stiffness-pressure relationship of the liver and spleen could provide a promising noninvasive method for assessing portal pressure. Using MRE to study the tissue mechanics associated with portal pressure may provide new insights into the natural history and pathophysiology of hepatic diseases and may have significant diagnostic value in the future. PMID:23418135

  5. Estimation of Quasi-Stiffness of the Human Hip in the Stance Phase of Walking

    PubMed Central

    Shamaei, Kamran; Sawicki, Gregory S.; Dollar, Aaron M.

    2013-01-01

    This work presents a framework for selection of subject-specific quasi-stiffness of hip orthoses and exoskeletons, and other devices that are intended to emulate the biological performance of this joint during walking. The hip joint exhibits linear moment-angular excursion behavior in both the extension and flexion stages of the resilient loading-unloading phase that consists of terminal stance and initial swing phases. Here, we establish statistical models that can closely estimate the slope of linear fits to the moment-angle graph of the hip in this phase, termed as the quasi-stiffness of the hip. Employing an inverse dynamics analysis, we identify a series of parameters that can capture the nearly linear hip quasi-stiffnesses in the resilient loading phase. We then employ regression analysis on experimental moment-angle data of 216 gait trials across 26 human adults walking over a wide range of gait speeds (0.75–2.63 m/s) to obtain a set of general-form statistical models that estimate the hip quasi-stiffnesses using body weight and height, gait speed, and hip excursion. We show that the general-form models can closely estimate the hip quasi-stiffness in the extension (R2?=?92%) and flexion portions (R2?=?89%) of the resilient loading phase of the gait. We further simplify the general-form models and present a set of stature-based models that can estimate the hip quasi-stiffness for the preferred gait speed using only body weight and height with an average error of 27% for the extension stage and 37% for the flexion stage. PMID:24349136

  6. Estimation of quasi-stiffness of the human hip in the stance phase of walking.

    PubMed

    Shamaei, Kamran; Sawicki, Gregory S; Dollar, Aaron M

    2013-01-01

    This work presents a framework for selection of subject-specific quasi-stiffness of hip orthoses and exoskeletons, and other devices that are intended to emulate the biological performance of this joint during walking. The hip joint exhibits linear moment-angular excursion behavior in both the extension and flexion stages of the resilient loading-unloading phase that consists of terminal stance and initial swing phases. Here, we establish statistical models that can closely estimate the slope of linear fits to the moment-angle graph of the hip in this phase, termed as the quasi-stiffness of the hip. Employing an inverse dynamics analysis, we identify a series of parameters that can capture the nearly linear hip quasi-stiffnesses in the resilient loading phase. We then employ regression analysis on experimental moment-angle data of 216 gait trials across 26 human adults walking over a wide range of gait speeds (0.75-2.63 m/s) to obtain a set of general-form statistical models that estimate the hip quasi-stiffnesses using body weight and height, gait speed, and hip excursion. We show that the general-form models can closely estimate the hip quasi-stiffness in the extension (R(2)?=?92%) and flexion portions (R(2)?=?89%) of the resilient loading phase of the gait. We further simplify the general-form models and present a set of stature-based models that can estimate the hip quasi-stiffness for the preferred gait speed using only body weight and height with an average error of 27% for the extension stage and 37% for the flexion stage. PMID:24349136

  7. Application of a local linearization technique for the solution of a system of stiff differential equations associated with the simulation of a magnetic bearing assembly

    NASA Technical Reports Server (NTRS)

    Kibler, K. S.; Mcdaniel, G. A.

    1981-01-01

    A digital local linearization technique was used to solve a system of stiff differential equations which simulate a magnetic bearing assembly. The results prove the technique to be accurate, stable, and efficient when compared to a general purpose variable order Adams method with a stiff option.

  8. Assessing Muscle Stiffness from Quiet Stance in Parkinson's Disease

    E-print Network

    Assessing Muscle Stiffness from Quiet Stance in Parkinson's Disease Michael Lauk 1;2;4 , MSc­761­203­7700, email: lauk@fdm.uni­freiburg.de Running head: Assessing stiffness in parkinsonism. #12; Assessing Muscle Stiffness from Quiet Stance: Applicability to Parkinson's Disease Abstract In previous studies, we developed

  9. Damage Detection on Sudden Stiffness Reduction Based on Discrete Wavelet Transform

    PubMed Central

    Chen, Bo; Chen, Zhi-wei; Wang, Gan-jun; Xie, Wei-ping

    2014-01-01

    The sudden stiffness reduction in a structure may cause the signal discontinuity in the acceleration responses close to the damage location at the damage time instant. To this end, the damage detection on sudden stiffness reduction of building structures has been actively investigated in this study. The signal discontinuity of the structural acceleration responses of an example building is extracted based on the discrete wavelet transform. It is proved that the variation of the first level detail coefficients of the wavelet transform at damage instant is linearly proportional to the magnitude of the stiffness reduction. A new damage index is proposed and implemented to detect the damage time instant, location, and severity of a structure due to a sudden change of structural stiffness. Numerical simulation using a five-story shear building under different types of excitation is carried out to assess the effectiveness and reliability of the proposed damage index for the building at different damage levels. The sensitivity of the damage index to the intensity and frequency range of measurement noise is also investigated. The made observations demonstrate that the proposed damage index can accurately identify the sudden damage events if the noise intensity is limited. PMID:24991647

  10. Strong and stiff aramid nanofiber/carbon nanotube nanocomposites.

    PubMed

    Zhu, Jiaqi; Cao, Wenxin; Yue, Mingli; Hou, Ying; Han, Jiecai; Yang, Ming

    2015-03-24

    Small but strong carbon nanotubes (CNTs) are fillers of choice for composite reinforcement owing to their extraordinary modulus and strength. However, the mechanical properties of the nanocomposites are still much below those for mechanical parameters of individual nanotubes. The gap between the expectation and experimental results arises not only from imperfect dispersion and poor load transfer but also from the unavailability of strong polymers that can be effectively utilized within the composites of nanotubes. Aramid nanofibers (ANFs) with analogous morphological features to nanotubes represent a potential choice to complement nanotubes given their intrinsic high mechanical performance and the dispersible nature, which enables solvent-based processing methods. In this work, we showed that composite films made from ANFs and multiwalled CNTs (MWCNTs) by vacuum-assisted flocculation and vacuum-assisted layer-by-layer assembly exhibited high ultimate strength of up to 383 MPa and Young's modulus (stiffness) of up to 35 GPa, which represent the highest values among all the reported random CNT nanocomposites. Detailed studies using different imaging and spectroscopic characterizations suggested that the multiple interfacial interactions between nanotubes and ANFs including hydrogen bonding and ?-? stacking are likely the key parameters responsible for the observed mechanical improvement. Importantly, our studies further revealed the attractive thermomechanical characteristics of these nanocomposites with high thermal stability (up to 520 °C) and ultralow coefficients of thermal expansion (2-6 ppm·K(-1)). Our results indicated that ANFs are promising nanoscale building blocks for functional ultrastrong and stiff materials potentially extendable to nanocomposites based on other nanoscale fillers. PMID:25712334

  11. Numerical solution of stiff systems of ordinary differential equations with applications to electronic circuits

    NASA Technical Reports Server (NTRS)

    Rosenbaum, J. S.

    1971-01-01

    Systems of ordinary differential equations in which the magnitudes of the eigenvalues (or time constants) vary greatly are commonly called stiff. Such systems of equations arise in nuclear reactor kinetics, the flow of chemically reacting gas, dynamics, control theory, circuit analysis and other fields. The research reported develops an A-stable numerical integration technique for solving stiff systems of ordinary differential equations. The method, which is called the generalized trapezoidal rule, is a modification of the trapezoidal rule. However, the method is computationally more efficient than the trapezoidal rule when the solution of the almost-discontinuous segments is being calculated.

  12. Contact Stiffness and Damping of Liquid Films in Dynamic Atomic Force Microscopy

    E-print Network

    Rong-Guang Xu; Yongsheng Leng

    2015-11-11

    Small-amplitude dynamic atomic force microscopy (dynamic-AFM) in a simple nonpolar liquid was studied through molecular dynamics simulations. We find that within linear dynamics regime, the contact stiffness and damping of the confined film exhibit the similar solvation force oscillations, and they are generally out-of-phase. For the solidified film with integer monolayer thickness, further compression of the film before layering transition leads to higher stiffness and lower damping. We find that molecular diffusion in the solidified film was nevertheless enhanced due to the mechanical excitation of AFM tip.

  13. Apparatus for measurement of coefficient of friction

    NASA Technical Reports Server (NTRS)

    Slifka, A. J.; Siegwarth, J. D.; Sparks, L. L.; Chaudhuri, Dilip K.

    1990-01-01

    An apparatus designed to measure the coefficient of friction in certain controlled atmospheres is described. The coefficient of friction observed during high-load tests was nearly constant, with an average value of 0.56. This value is in general agreement with that found in the literature and also with the initial friction coefficient value of 0.67 measured during self-mated friction of 440C steel in an oxygen environment.

  14. Electron profile stiffness and critical gradient studies

    SciTech Connect

    DeBoo, J. C.; Petty, C. C.; Burrell, K. H.; Smith, S. P.; White, A. E.; Doyle, E. J.; Hillesheim, J. C.; Rhodes, T. L.; Schmitz, L.; Wang, G.; Zeng, L.; Holland, C.; McKee, G. R.

    2012-08-15

    Electron profile stiffness was studied in DIII-D L-mode discharges by systematically varying the heat flux in a narrow region with electron cyclotron heating and measuring the local change produced in {nabla}T{sub e}. Electron stiffness was found to slowly increase with toroidal rotation velocity. A critical inverse temperature gradient scale length 1/L{sub C} {approx} 3 m{sup -1} was identified at {rho}=0.6 and found to be independent of rotation. Both the heat pulse diffusivity and the power balance diffusivity, the latter determined by integrating the measured dependence of the heat pulse diffusivity on -{nabla}T{sub e}, were fit reasonably well by a model containing a critical inverse temperature gradient scale length and varying linearly with 1/L{sub T} above the threshold.

  15. Light weight high-stiffness stage platen

    DOEpatents

    Spence, Paul A. (Pleasanton, CA)

    2001-01-01

    An improved light weight, stiff stage platen for photolithography is provided. The high stiffness of the stage platen is exemplified by a relatively high first resonant vibrational mode as determined, for instance, by finite element modal analysis. The stage platen can be employed to support a chuck that is designed to secure a mask or wafer. The stage platen includes a frame that has interior walls that define an interior region and that has exterior walls wherein the outer surfaces of at least two adjacent walls are reflective mirror surfaces; and a matrix of ribs within the interior region that is connected to the interior walls wherein the stage platen exhibits a first vibrational mode at a frequency of greater than about 1000 Hz.

  16. Microfinish As A Function Of Machine Stiffness

    NASA Astrophysics Data System (ADS)

    Watt, Gordon J.

    1987-01-01

    Stiffness of a machine must be known between the tip of the cutting tool and the surface being machined in order to correlate with microfinish. Signature of the machine tool and its environs are registered on the micro-machined surface. Imperfections are triggered by disturbances which may originate off the machine, from the machine, or by reaction between the tool and the workpiece. The machine transfer function is a complex mechanical system with many input points and resonance frequencies to be contended with. This paper deals with recognizable surface imperfections which are related back to mechanical parameters in and between the machine elements. To be complete, one must include spindles, slides, supports, vibration isolators, tool holders, tools, fixtures, and the workpiece itself. Their relation to sources of disturbance is discussed and examples are given of surface measurements made which identify the relation between machine stiffness and microfinish signatures.

  17. Textural and sensory properties of trifoliate yam (Dioscorea dumetorum) flour and stiff dough 'amala'.

    PubMed

    Abiodun, O A; Akinoso, R

    2015-05-01

    The use of trifoliate yam (Dioscorea dumetorum) flour for stiff dough 'amala' production is one of the ways to curb under-utilization of the tuber. The study evaluates the textural and sensory properties of trifoliate yam flour and stiff dough. Freshly harvested trifoliate yam tubers were peeled, washed, sliced and blanched (60?(°)C for 10 min). The sliced yam were soaked in water for 12 h, dried and milled into flour. Pasting viscosities, functional properties, brown index and sensory attributes of the flour and stiff dough were analyzed. Peak, holding strength and final viscosities ranged from 84.09 to 213.33 RVU, 81.25 to 157.00 RVU and 127.58 to 236.17 RVU respectively. White raw flour had higher viscosity than the yellow flours. The swelling index, water absorption capacity and bulk density ranged from 1.46 to 2.28, 2.11 to 2.92 ml H2O/g and 0.71 to 0.88 g/cm(3) respectively. Blanching method employed improved the swelling index and water absorption capacity of flour. The brown index values of flour and stiff dough ranged from 6.73 to 18.36 and 14.63-46.72 respectively. Sensory evaluation revealed significant differences in the colour, odour and general acceptability of the product when compared with the stiff dough from white yam. PMID:25892788

  18. Methods for evaluating changes in cartilage stiffness following electromechanical reshaping

    NASA Astrophysics Data System (ADS)

    Lim, Amanda; Protsenko, Dmitriy E.; Wong, Brian J. F.

    2010-02-01

    One common component of otolaryngological surgeries is the reshaping of cartilage. Previous studies have demonstrated the efficient achievement of this procedure through electromechanical reshaping (EMR), a technique that involves the direct application of voltage to cartilage that is mechanically deformed in a jig. Two main parameters, voltage and application time, may be regulated to achieve varying degrees of shape change. Although prior research has correlated these EMR parameters with degree of shape change, it remains necessary to correlate the same parameters with the degree of change in the mechanical properties of tissue. Once this is accomplished, an ideal balance may be determined, in which shape change is maximized while intrinsic tissue damage is minimized This study satisfies this need by providing comprehensive data on the pre- and post-EMR stiffness of both septal and auricular cartilage over a range of voltages (2-8V) with constant application time (2 min for septal, 3 min for auricular). EMR was applied using flat platinum electrodes to one of two 15 mm X 5 mm samples obtained from the same cartilage specimen, while the second sample was maintained as a control. Following a 15 min re-hydration period, the Young's modulus of the tissue was calculated for both the control and experimental sample from data obtained through a uniaxial tension test. A general reduction in stiffness was observed beginning at 3V, with the magnitude of reduction increasing at 6V.

  19. A new method for accurately determining the modal equivalent stiffness ratio of bonded piezoelectric structures

    NASA Astrophysics Data System (ADS)

    Yamada, Keisuke; Matsuhisa, Hiroshi; Utsuno, Hideo

    2012-07-01

    This paper describes new methods for measuring the modal equivalent stiffness ratios and modal electromechanical coupling coefficients of piezoelectric elements attached to a host structure such as a beam. Modal equivalent stiffness ratios and modal electromechanical coupling coefficients are essential for estimating the performance and determining an optimum design of active vibration control and passive vibration suppression systems that use piezoelectric elements. Accurate determination of these modal parameters is also useful for other systems including piezoelectric sensors and energy generators. This paper not only describes the measurement methods but also presents the theoretical formulations derived by taking into account the effect of adhesive bonds. The formulations in this paper demonstrate the necessity of experimental measurements and the accuracy enhancements that the theoretical estimations can provide. Conventional methods for obtaining the modal equivalent stiffness ratios are sensitive to measurement errors, which result in the loss of accuracy, rendering these methods unreliable for many practical applications. The proposed methods use an inductor instead of an open circuit to address the abovementioned issue and, thereby, provide significant improvement in the accuracy. Because the loss factors of the experimental apparatus tend to compromise the accuracy of the proposed methods, a method using a negative resistor is proposed, theoretically analyzed, and confirmed to eliminate some of the errors introduced by loss factors. The advantages of the proposed methods and the effectiveness of theoretical analysis, considering the effect of adhesive bonds, are verified experimentally.

  20. Nonaffine rubber elasticity for stiff polymer networks

    E-print Network

    C. Heussinger; B. Schaefer; E. Frey

    2007-11-26

    We present a theory for the elasticity of cross-linked stiff polymer networks. Stiff polymers, unlike their flexible counterparts, are highly anisotropic elastic objects. Similar to mechanical beams stiff polymers easily deform in bending, while they are much stiffer with respect to tensile forces (``stretching''). Unlike in previous approaches, where network elasticity is derived from the stretching mode, our theory properly accounts for the soft bending response. A self-consistent effective medium approach is used to calculate the macroscopic elastic moduli starting from a microscopic characterization of the deformation field in terms of ``floppy modes'' -- low-energy bending excitations that retain a high degree of non-affinity. The length-scale characterizing the emergent non-affinity is given by the ``fiber length'' $l_f$, defined as the scale over which the polymers remain straight. The calculated scaling properties for the shear modulus are in excellent agreement with the results of recent simulations obtained in two-dimensional model networks. Furthermore, our theory can be applied to rationalize bulk rheological data in reconstituted actin networks.

  1. Coupling Multiple Stiff Processes in Reactive Flows

    NASA Astrophysics Data System (ADS)

    Boris, Jay P.; Oran, Elaine S.; Patnaik, Gopal

    1999-11-01

    This paper describes a new, Compenstated Operator-Split (COS) methodology for coupling several distinct, mathematically stiff, reactive flow processes into a dynamic simulation model. Operator-splitting (also called process-splitting or timestep-splitting) is the simplest way to build detailed numerical models containing a number of different reactive flow processes and allows use of optimal algorithms for each of the processes individually [Oran and Boris, 1987]. However, explicit operator-splitting performs poorly in situations where two or more of the processes are ``stiff'' and thus require unacceptably small timesteps. Global implicit coupling can in principle be used for these cases, but the computational cost becomes prohibitive, the programming is often complex, there are serious algorithmic restrictions, and the accuracy can be quite low. We describe how operator-splitting can be extended to a broad class of problems with interacting stiff processes without the limitations of a global implicit framework. (Work Sponsored by ONR through the Naval Research Laboratory.)

  2. Commentary on Coefficient Alpha: A Cautionary Tale

    ERIC Educational Resources Information Center

    Green, Samuel B.; Yang, Yanyun

    2009-01-01

    The general use of coefficient alpha to assess reliability should be discouraged on a number of grounds. The assumptions underlying coefficient alpha are unlikely to hold in practice, and violation of these assumptions can result in nontrivial negative or positive bias. Structural equation modeling was discussed as an informative process both to…

  3. Friction Coefficient for Quarks in Supergravity Duals

    E-print Network

    E. Antonyan

    2006-11-22

    We study quarks moving in strongly-coupled plasmas that have supergravity duals. We compute the friction coefficient of strings dual to such quarks for general static supergravity backgrounds near the horizon. Our results also show that a previous conjecture on the bound has to be modified and higher friction coefficients can be achieved.

  4. An improved spinning lens test to determine the stiffness of the human lens

    PubMed Central

    Burd, H.J.; Wilde, G.S.; Judge, S.J.

    2011-01-01

    It is widely accepted that age-related changes in lens stiffness are significant for the development of presbyopia. However, precise details on the relative importance of age-related changes in the stiffness of the lens, in comparison with other potential mechanisms for the development of presbyopia, have not yet been established. One contributing factor to this uncertainty is the paucity and variability of experimental data on lens stiffness. The available published data generally indicate that stiffness varies spatially within the lens and that stiffness parameters tend to increase with age. However, considerable differences exist between these published data sets, both qualitatively and quantitatively. The current paper describes new and improved methods, based on the spinning lens approach pioneered by Fisher, R.F. (1971) ‘The elastic constants of the human lens’, Journal of Physiology, 212, 147–180, to make measurements on the stiffness of the human lens. These new procedures have been developed in an attempt to eliminate, or at least substantially reduce, various systematic errors in Fisher’s original experiment. An improved test rig has been constructed and a new modelling procedure for determining lens stiffness parameters from observations made during the test has been devised. The experiment involves mounting a human lens on a vertical rotor so that the lens spins on its optical axis (typically at 1000 rpm). An automatic imaging system is used to capture the outline of the lens, while it is rotating, at pre-determined angular orientations. These images are used to quantify the deformations developed in the lens as a consequence of the centripetal forces induced by the rotation. Lens stiffness is inferred using axisymmetric finite element inverse analysis in which a nearly-incompressible neo-Hookean constitutive model is used to represent the mechanics of the lens. A numerical optimisation procedure is used to determine the stiffness parameters that provide a best fit between the finite element model and the experimental data. Sample results are presented for a human lens of age 33 years. PMID:21040722

  5. An Ordinal Coefficient of Relational Agreement for Multiple Judges.

    ERIC Educational Resources Information Center

    Fagot, Robert F.

    1994-01-01

    A previous paper proposed a generalized family of coefficients of relational agreement for multiple judges. It focused on the concept of empirically meaningful relationships. This paper presents an ordinal coefficient of relational agreement as a special case of the generalized family. The proposed ordinal coefficient encompasses other ordinal…

  6. The directional dependence of elastic stiffness and compliance shear coefficients and shear moduli in cubic materials

    E-print Network

    Knowles, Kevin M.; Howie, Philip R.

    2014-12-31

    as a function of direction in the (100) and (110) planes, in which the radius vector is in the K.M. Knowles (B) · P.R. Howie Department of Materials Science and Metallurgy, University of Cambridge, 27 Charles Babbage Road, Cambridge, CB3 0FS, UK e...

  7. Experimental frequency-dependent rotordynamic coefficients for a load-on-pad, high-speed, flexible-pivot tilting-pad bearing 

    E-print Network

    Rodriguez Colmenares, Luis Emigdio

    2004-09-30

    This thesis provides experimental frequency dependent stiffness and damping coefficient results for a high-speed, lightly loaded, flexible-pivot tilting-pad bearing, with a load-on-pad configuration. Test conditions include four shaft speeds (6000...

  8. Identifying Bearing Rotodynamic Coefficients Using an Extended Kalman Filter

    NASA Technical Reports Server (NTRS)

    Miller, Brad A.; Howard, Samuel A.

    2008-01-01

    An Extended Kalman Filter is developed to estimate the linearized direct and indirect stiffness and damping force coefficients for bearings in rotor dynamic applications from noisy measurements of the shaft displacement in response to imbalance and impact excitation. The bearing properties are modeled as stochastic random variables using a Gauss-Markov model. Noise terms are introduced into the system model to account for all of the estimation error, including modeling errors and uncertainties and the propagation of measurement errors into the parameter estimates. The system model contains two user-defined parameters that can be tuned to improve the filter's performance; these parameters correspond to the covariance of the system and measurement noise variables. The filter is also strongly influenced by the initial values of the states and the error covariance matrix. The filter is demonstrated using numerically simulated data for a rotor bearing system with two identical bearings, which reduces the number of unknown linear dynamic coefficients to eight. The filter estimates for the direct damping coefficients and all four stiffness coefficients correlated well with actual values, whereas the estimates for the cross-coupled damping coefficients were the least accurate.

  9. Identifying Bearing Rotordynamic Coefficients using an Extended Kalman Filter

    NASA Technical Reports Server (NTRS)

    Miller, Bard A.; Howard, Samuel A.

    2008-01-01

    An Extended Kalman Filter is developed to estimate the linearized direct and indirect stiffness and damping force coefficients for bearings in rotor-dynamic applications from noisy measurements of the shaft displacement in response to imbalance and impact excitation. The bearing properties are modeled as stochastic random variables using a Gauss-Markov model. Noise terms are introduced into the system model to account for all of the estimation error, including modeling errors and uncertainties and the propagation of measurement errors into the parameter estimates. The system model contains two user-defined parameters that can be tuned to improve the filter s performance; these parameters correspond to the covariance of the system and measurement noise variables. The filter is also strongly influenced by the initial values of the states and the error covariance matrix. The filter is demonstrated using numerically simulated data for a rotor-bearing system with two identical bearings, which reduces the number of unknown linear dynamic coefficients to eight. The filter estimates for the direct damping coefficients and all four stiffness coefficients correlated well with actual values, whereas the estimates for the cross-coupled damping coefficients were the least accurate.

  10. Impact of diabetes mellitus on arterial stiffness in a representative sample of an urban Brazilian population

    PubMed Central

    2013-01-01

    Background Independent of other cardiovascular (CV) risk factors, increased arterial stiffness has been established as a predictor of morbidity and mortality. The main aim of this study was to investigate the impact of diabetes on arterial stiffness in a representative sample of an urban Brazilian population plus Amerindians. Methods A total of 1,415 individuals from the general population were randomly selected plus 588 Amerindians from a native community in Brazil. In addition, a sub-sample of 380 individuals from the general population had 5-year follow-up data. Pulse wave velocity (PWV) was measured with a non-invasive automatic device (Complior, Colson; Garges les Gonesses, France) and increased arterial stiffness was defined as PWV???12 m/s. Results In the overall group, diabetic individuals had higher frequencies of increased arterial stiffness and hypertension. They also had higher values of PWV, body mass index, total cholesterol, triglycerides, systolic and diastolic blood pressures compared to non-diabetic individuals (p?stiffness frequency were higher in diabetic individuals in both groups (hypertensive and non-hypertensive) (p?stiffness was observed in the diabetic individuals from the overall group (OR?=?2.27; CI?=?1.47-3.52, p?stiffness compared to non-diabetic individuals. Both diabetic and non-diabetic individuals had higher PWV values after 5 years. There was no significant difference in the 5-year PWV progression in diabetic compared to non-diabetic individuals. Conclusions These results confirm, in a sample of Brazilian population, that the presence of diabetes is associated with increased arterial stiffness and it may contribute in part to increased cardiovascular risk in diabetic patients. PMID:23965633

  11. Laser application on haptics: Tactile stiffness measurement

    NASA Astrophysics Data System (ADS)

    Scalise, L.; Memeo, M.; Cannella, F.; Valente, M.; Caldwell, D. G.; Tomasini, E. P.

    2012-06-01

    There is a great interest in exploring the proprieties of the sense of the touch, its detailed knowledge in fact is a key issue in the area of robotics, haptics and human-machine interaction. In this paper, the authors focus their attention on a novel measurement method for the assessment of the tactile stiffness based on a original test rig; tactile stiffness is defined as the ratio between force, exerted by the finger, and the displacement of the finger tip operated during the test. To reach this scope, the paper describes a specific experimental test-rig used for the evaluation of subject tactile sensitivity, where finger force applied during tests as well as displacement and velocity of displacement, operated by the subject under investigation, are measured. Results show that tactile stiffness is linear respect to stimuli spatial difference (which is proportional to the difficulty to detect the variation of them). In particular, it has been possible to relate the force and displacement measured during the tests. The relationship between the response of the subject to the grating, velocity and force is determined. These results permit to carry out the further experimental tests on the same subject avoiding the use of a load cell and therefore simplifying the measurement test rig and data post-processing. Indeed, the first aspect (use of a load cell) can be relevant, because the grating positions are different, requiring a specific re-calibration and setting before each trial; while the second aspect allows simplify the test rig complexity and the processing algorithm.

  12. Relative stiffness of flat conductor cables

    NASA Technical Reports Server (NTRS)

    Hankins, J. D.

    1976-01-01

    The measurement of the bending moment required to obtain a given deflection in short lengths of flat conductor cable (FCC) is presented in this report. Experimental data were taken on 10 different samples of FCC and normalized to express all bending moments (relative stiffness factor) in terms of a cable 5.1 cm (2.0 in.) in width. Data are presented in tabular and graphical form for the covenience of designers who may be interested in finding torques exerted on critical components by short lengths of FCC.

  13. Effects of non-uniform stiffness on the swimming performance of a passively-flexing, fish-like foil model.

    PubMed

    Lucas, Kelsey N; Thornycroft, Patrick J M; Gemmell, Brad J; Colin, Sean P; Costello, John H; Lauder, George V

    2015-10-01

    Simple mechanical models emulating fish have been used recently to enable targeted study of individual factors contributing to swimming locomotion without the confounding complexity of the whole fish body. Yet, unlike these uniform models, the fish body is notable for its non-uniform material properties. In particular, flexural stiffness decreases along the fish's anterior-posterior axis. To identify the role of non-uniform bending stiffness during fish-like propulsion, we studied four foil model configurations made by adhering layers of plastic sheets to produce discrete regions of high (5.5 × 10(-5) Nm(2)) and low (1.9 × 10(-5) Nm(2)) flexural stiffness of biologically-relevant magnitudes. This resulted in two uniform control foils and two foils with anterior regions of high stiffness and posterior regions of low stiffness. With a mechanical flapping foil controller, we measured forces and torques in three directions and quantified swimming performance under both heaving (no pitch) and constant 0° angle of attack programs. Foils self-propelled at Reynolds number 21 000-115 000 and Strouhal number ?0.20-0.25, values characteristic of fish locomotion. Although previous models have emphasized uniform distributions and heaving motions, the combination of non-uniform stiffness distributions and 0° angle of attack pitching program was better able to reproduce the kinematics of freely-swimming fish. This combination was likewise crucial in maximizing swimming performance and resulted in high self-propelled speeds at low costs of transport and large thrust coefficients at relatively high efficiency. Because these metrics were not all maximized together, selection of the 'best' stiffness distribution will depend on actuation constraints and performance goals. These improved models enable more detailed, accurate analyses of fish-like swimming. PMID:26447541

  14. Postprandial effects on arterial stiffness parameters in healthy young adults.

    PubMed

    Murray, Tyler; Yang, Eric Y; Brunner, Gerd; Kumar, Anirudh; Lakkis, Nasser; Misra, Arunima; Virani, Salim S; Hartley, Craig J; Morrisett, Joel D; Ballantyne, Christie M; Nambi, Vijay

    2015-12-01

    Postprandial lipemia has been associated with acute endothelial dysfunction. Endothelial dysfunction, in turn, is associated with increased arterial stiffness. However, the relationship between postprandial lipemia and acute changes in arterial stiffness has not been extensively investigated. Therefore, we conducted a pilot study on the effects of postprandial lipemia on arterial stiffness in 19 healthy young adults before and after consumption of a high-fat mixed meal. Arterial stiffness was assessed locally with echo-tracking carotid arterial strain (CAS) and globally with carotid-femoral pulse wave velocity (PWV). As assessed by these two benchmark parameters, arterial stiffness did not differ significantly postprandially. However, the arterial distension period (ADP) was significantly lower 2 hours after mixed meal ingestion. In addition, slopes of carotid artery area (CAA) curves were significantly steeper postprandially. Therefore, we concluded that ADP may be a more sensitive marker of arterial stiffness in healthy young adults when compared to PWV and CAS. PMID:26060082

  15. Stiffness Dependent Separation of Cells in a Microfluidic Device

    NASA Astrophysics Data System (ADS)

    Sulchek, Todd; Wang, Gonghao; Mao, Wenbin; Henegar, Caitlin; Alexeev, Alexander

    2012-02-01

    Abnormal cell mechanical stiffness can point to the development of various diseases including cancers and infections. We report a new high-throughput technique for continuous cell separation utilizing variation in cell stiffness. We use a microfluidic channel decorated by periodic diagonal ridges to separate K562 lymphoblastic cell line modified to different mechanical stiffness values. Diagonal ridges within the microfluidic flow channel compress and deform the cells in rapid succession to translate each cell perpendicular to the channel axis in proportion to its stiffness. Atomic force microscopy (AFM) was used to directly measure the Young's modulus of modified K562 cells to verify the stiffness variation. We demonstrate that soft cells can be separated from stiff cells at physiological concentrations with a fivefold enrichment of cell populations. This microfluidic device opens the way for conducting rapid and low-cost cell analysis and purification through physical markers.

  16. Digital Photoplethysmography for Assessment of Arterial Stiffness: Repeatability and Comparison with Applanation Tonometry

    PubMed Central

    Östling, Gerd; Nilsson, Peter M.

    2015-01-01

    Introduction Arterial stiffness is an independent risk factor for cardiovascular morbidity and can be assessed by applanation tonometry by measuring pulse wave velocity (PWV) and augmentation index (AIX) by pressure pulse wave analysis (PWA). As an inexpensive and operator independent alternative, photoelectric plethysmography (PPG) has been introduced with analysis of the digital volume pulse wave (DPA) and its second derivatives of wave reflections. Objective The objective was to investigate the repeatability of arterial stiffness parameters measured by digital pulse wave analysis (DPA) and the associations to applanation tonometry parameters. Methods and Results 112 pregnant and non-pregnant individuals of different ages and genders were examined with SphygmoCor arterial wall tonometry and Meridian DPA finger photoplethysmography. Coefficients of repeatability, Bland-Altman plots, intraclass correlation coefficients and correlations to heart rate (HR) and body height were calculated for DPA variables, and the DPA variables were compared to tonometry variables left ventricular ejection time (LVET), PWV and AIX. No DPA variable showed any systematic measurement error or excellent repeatability, but dicrotic index (DI), dicrotic dilatation index (DDI), cardiac ejection elasticity index (EEI), aging index (AI) and second derivatives of the crude pulse wave curve, b/a and e/a, showed good repeatability. Overall, the correlations to AIX were better than to PWV, with correlations coefficients >0.70 for EEI, AI and b/a. Considering the level of repeatability and the correlations to tonometry, the overall best DPA parameters were EEI, AI and b/a. The two pansystolic time parameters, ejection time compensated (ETc) by DPA and LVET by tonometry, showed a significant but weak correlation. Conclusion For estimation of the LV function, ETc, EEI and b/a are suitable, for large artery stiffness EEI, and for small arteries DI and DDI. The only global parameter, AI, showed a high repeatability and the overall best correlations with AIX and PWV. PMID:26291079

  17. Dynamics of a Gear System with Faults in Meshing Stiffness

    E-print Network

    Grzegorz Litak; Michael I. Friswell

    2004-05-23

    Gear box dynamics is characterised by a periodically changing stiffness. In real gear systems, a backlash also exists that can lead to a loss in contact between the teeth. Due to this loss of contact the gear has piecewise linear stiffness characteristics, and the gears can vibrate regularly and chaotically. In this paper we examine the effect of tooth shape imperfections and defects. Using standard methods for nonlinear systems we examine the dynamics of gear systems with various faults in meshing stiffness.

  18. Experiments on dynamic stiffness and damping of tapered bore seals

    NASA Technical Reports Server (NTRS)

    Fleming, David P.

    1987-01-01

    Stiffness and damping were measured in tapered bore ring seals with air as the sealed fluid. Excitation was provided by a known unbalance in the shaft which rotated in the test seals. Results were obtained for various seal supply pressures, clearances, unbalance amounts, and shaft speeds. Stiffness and damping varied little with unbalance level, indicating linearity of the seal. Greater variation was observed with speed and particularly supply pressure. A one-dimensional analysis predicted stiffness fairly well, but considerably overestimated damping.

  19. Towards ultra-stiff materials: Surface effects on nanoporous materials

    SciTech Connect

    Lu, Dingjie; Xie, Yi Min; Huang, Xiaodong; Zhou, Shiwei; Li, Qing

    2014-09-08

    The significant rise in the strength and stiffness of porous materials at nanoscale cannot be described by conventional scaling laws. This letter investigates the effective Young's modulus of such materials by taking into account surface effect in a microcellular architecture designed for an ultralight material whose stiffness is an order of magnitude higher than most porous materials. We find that by considering the surface effects the predicted stiffness using Euler-Bernoulli beam theory compares well to experimental data for spongelike nanoporous gold with random microstructures. Analytical results show that, of the two factors influencing the effective Young's modulus, the residual stress is more important than the surface stiffness.

  20. Serum Mimecan Is Associated With Arterial Stiffness in Hypertensive Patients

    PubMed Central

    Gu, Xiaosong; Zhao, Liangping; Zhu, Jing; Gu, Haibo; Li, Hui; Wang, Luchen; Xu, Weiting; Chen, Jianchang

    2015-01-01

    Background Mimecan plays an important role in endothelial and vascular smooth muscle cell integrity and may be involved the pathology of arterial stiffness. However, the role of mimecan in arterial stiffness in patients with hypertension is not well defined. Methods and Results A total of 116 hypertension patients and 54 healthy controls were enrolled in the investigation. Hypertensive patients were divided into 2 groups: the with arterial stiffness group (brachial-ankle pulse wave velocity [baPWV] ?1400 cm/s; n=83) and the without arterial stiffness group (baPWV <1400 cm/s; n=33). A noninvasive measure of vascular stiffness was performed using pulse wave velocity (PWV) measurement of baPWV. Hypertensive patients had higher baPWV, mimecan, and endothelin 1 (ET-1) than healthy controls. The arterial stiffness group had higher mimecan and endothelin 1 (ET-1) and lower ankle-brachial pressure index (ABI) than those without stiffness. In hypertensive patients, mimecan was inversely correlated with ABI (P<0.05) and positively correlated with baPWV, ET-1, and total cholesterol. On multivariable logistic regression analysis, diastolic blood pressure, mimecan, ET-1, and creatinine were independent predictors of arterial stiffness in hypertensive patients (P<0.05). Conclusions Mimecan levels are higher in hypertensive patients than in healthy controls. Increased plasma mimecan levels are independently associated with increased arterial stiffness as assessed by baPWV. PMID:26206738

  1. The SSME HPFTP interstage seals: Analysis and experiments for leakage and reaction-force coefficients

    NASA Technical Reports Server (NTRS)

    Childs, D. W.

    1983-01-01

    An improved theory for the prediction of the rotordynamic coefficients of turbulent annular seals was developed. Predictions from the theory are compared to the experimental results and an approach for the direct calculation of empirical turbulent coefficients from test data are introduced. An improved short seal solution is shown to do a better job of calculating effective stiffness and damping coefficients than either the original short seal solution or a finite length solution. However, the original short seal solution does a much better job of predicting equivalent added mass coefficient.

  2. Metabolic syndrome is associated with change in subclinical arterial stiffness - A community-based Taichung Community Health Study

    PubMed Central

    2011-01-01

    Background The aim of this study was to evaluate the effect of MetS on arterial stiffness in a longitudinal study. Methods Brachial-ankle pulse wave velocity (baPWV), a measurement interpreted as arterial stiffness, was measured in 1518 community-dwelling persons at baseline and re-examined within a mean follow-up period of 3 years. Multivariate linear regression with generalized estimating equations (GEE) were used to examine the longitudinal relationship between MetS and its individual components and baPWV, while multivariate logistic regression with GEE was used to examine the longitudinal relationship between MetS and its individual components and the high risk group with arterial stiffness. Results Subjects with MetS showed significantly greater baPWV at the end point than those without MetS, after adjusting for age, gender, education, hypertension medication and mean arterial pressure (MAP). MetS was associated with the top quartile of baPWV (the high-risk group of arterial stiffness, adjusted odds ratio [95% confidence interval] 1.52 [1.21-1.90]), and a significant linear trend of risk for the number of components of MetS was found (p for trend < 0.05). In further considering the individual MetS component, elevated blood pressure and fasting glucose significantly predicted a high risk of arterial stiffness (adjusted OR [95% CI] 3.72 [2.81-4.93] and 1.35 [1.08-1.68], respectively). Conclusions MetS affects the subject's progression to arterial stiffness. Arterial stiffness increased as the number of MetS components increased. Management of MetS is important for preventing the progression to advanced arterial stiffness. PMID:21999611

  3. The role of gravity or pressure and contact stiffness in granular rheology

    NASA Astrophysics Data System (ADS)

    Singh, Abhinendra; Magnanimo, Vanessa; Saitoh, Kuniyasu; Luding, Stefan

    2015-04-01

    The steady-state shear rheology of granular materials is investigated in slow quasistatic and inertial flows. The effect of gravity (thus the local pressure) and the often-neglected contact stiffness are the focus of this study. A series of particle simulations are performed on a weakly frictional granular assembly in a split-bottom geometry considering various magnitudes of gravity and contact stiffnesses. While traditionally the inertial number, i.e., the ratio of stress to strain-rate time scales, is used to describe the flow rheology, we report that a second dimensionless number, the ratio of softness and stress time scales, must also be included to characterize the bulk flow behavior. For slow, quasistatic flows, the density increases while the effective (macroscopic) friction decreases with increase in either particle softness or local pressure. This trend is added to the ? (I) rheology and can be traced back to the anisotropy in the contact network, displaying a linear correlation between the effective friction coefficient and deviatoric fabric in the steady state. When the external rotation rate is increased towards the inertial regime, for a given gravity field and contact stiffness, the effective friction increases faster than linearly with the deviatoric fabric.

  4. Quantitative assessment of sample stiffness and sliding friction from force curves in atomic force microscopy

    SciTech Connect

    Pratt, Jon R.; Shaw, Gordon A.; Kumanchik, Lee; Burnham, Nancy A.

    2010-02-15

    It has long been recognized that the angular deflection of an atomic force microscope (AFM) cantilever under ''normal'' loading conditions can be profoundly influenced by the friction between the tip and the surface. It is shown here that a remarkably quantifiable hysteresis occurs in the slope of loading curves whenever the normal flexural stiffness of the AFM cantilever is greater than that of the sample. This situation arises naturally in cantilever-on-cantilever calibration, but also when trying to measure the stiffness of nanomechanical devices or test structures, or when probing any type of surface or structure that is much more compliant along the surface normal than in transverse directions. Expressions and techniques for evaluating the coefficient of sliding friction between the cantilever tip and sample from normal force curves, as well as relations for determining the stiffness of a mechanically compliant specimen are presented. The model is experimentally supported by the results of cantilever-on-cantilever spring constant calibrations. The cantilever spring constants determined here agree with the values determined using the NIST electrostatic force balance within the limits of the largest uncertainty component, which had a relative value of less than 2.5%. This points the way for quantitative testing of micromechanical and nanomechanical components, more accurate calibration of AFM force, and provides nanotribologists access to information about contact friction from normal force curves.

  5. Pulmonary vascular wall stiffness: An important contributor to the increased right ventricular afterload with pulmonary hypertension

    PubMed Central

    Wang, Zhijie; Chesler, Naomi C.

    2011-01-01

    Pulmonary hypertension (PH) is associated with structural and mechanical changes in the pulmonary vascular bed that increase right ventricular (RV) afterload. These changes, characterized by narrowing and stiffening, occur in both proximal and distal pulmonary arteries (PAs). An important consequence of arterial narrowing is increased pulmonary vascular resistance (PVR). Arterial stiffening, which can occur in both the proximal and distal pulmonary arteries, is an important index of disease progression and is a significant contributor to increased RV afterload in PH. In particular, arterial narrowing and stiffening increase the RV afterload by increasing steady and oscillatory RV work, respectively. Here we review the current state of knowledge of the causes and consequences of pulmonary arterial stiffening in PH and its impact on RV function. We review direct and indirect techniques for measuring proximal and distal pulmonary arterial stiffness, measures of arterial stiffness including elastic modulus, incremental elastic modulus, stiffness coefficient ? and others, the changes in cellular function and the extracellular matrix proteins that contribute to pulmonary arterial stiffening, the consequences of PA stiffening for RV function and the clinical implications of pulmonary vascular stiffening for PH progression. Future investigation of the relationship between PA stiffening and RV dysfunction may facilitate new therapies aimed at improving RV function and thus ultimately reducing mortality in PH. PMID:22034607

  6. Cellular mechanoadaptation to substrate mechanical properties: contributions of substrate stiffness and thickness to cell stiffness measurements using AFM.

    PubMed

    Vichare, Shirish; Sen, Shamik; Inamdar, Mandar M

    2014-02-28

    Mechanosensing by adherent cells is usually studied by quantifying cell responses on hydrogels that are covalently linked to a rigid substrate. Atomic force microscopy (AFM) represents a convenient way of characterizing the mechanoadaptation response of adherent cells on hydrogels of varying stiffness and thickness. Since AFM measurements reflect the effective cell stiffness, therefore, in addition to measuring real cytoskeletal alterations across different conditions, these measurements might also be influenced by the geometry and physical properties of the substrate itself. To better understand how the physical attributes of the gel influence AFM stiffness measurements of cells, we have used finite element analysis to simulate the indentation of cells of various spreads resting on hydrogels of varying stiffness and thickness. Consistent with experimental results, our simulation results indicate that for well spread cells, stiffness values are significantly over-estimated when experiments are performed on cells cultured on soft and thin gels. Using parametric studies, we have developed scaling relationships between the effective stiffness probed by AFM and the bulk cell stiffness, taking cell and tip geometry, hydrogel properties, nuclear stiffness and cell contractility into account. Finally, using simulated mechanoadaptation responses, we have demonstrated that a cell stiffening response may arise purely due to the substrate properties. Collectively, our results demonstrate the need to take hydrogel properties into account while estimating cell stiffness using AFM indentation. PMID:24651595

  7. Extending the Constant Coefficient Solution Technique to Variable Coefficient Ordinary Differential Equations

    ERIC Educational Resources Information Center

    Mohammed, Ahmed; Zeleke, Aklilu

    2015-01-01

    We introduce a class of second-order ordinary differential equations (ODEs) with variable coefficients whose closed-form solutions can be obtained by the same method used to solve ODEs with constant coefficients. General solutions for the homogeneous case are discussed.

  8. A short note on the counter-intuitive spurious behaviors in stiff reacting flow

    NASA Astrophysics Data System (ADS)

    Zhang, Bin; Wang, Jian-Hang

    2015-06-01

    A well known spurious numerical phenomenon may occur in solving stiff detonation problems due to the under-resolved numerical solution in both space and time. Most people believe that decreasing numerical dissipation or stiffness will delay or eliminate the onset of spurious numerical phenomenon. However, several counter-intuitive spurious behaviors were observed by H.C. Yee et al. (2013) [10] recently and the mechanism of the generation of these strange phenomena remains an open question. The goal of this short note is to give a reasonable explanation for these counter-intuitive spurious behaviors existing in the detonation problems (the simplified 2 × 2 system and the reactive Euler equations) with stiff reacting source terms and discontinuities. In developing the mechanism of spurious numerical phenomenon in detonation problems, we find the parameters of the intermediate state are very important because they determine whether the spurious phenomenon will happen or not. Furthermore, these counter-intuitive spurious behaviors are mainly due to the oscillation of those intermediate state parameters as the time step or grid is refined gradually. These findings may help us to get a further understanding of some of the difficulties in numerical combustion and problems with stiff nonlinear source terms and discontinuities in general.

  9. Evaluation of Compressive Strength and Stiffness of Grouted Soils by Using Elastic Waves

    PubMed Central

    Lee, In-Mo; Kim, Jong-Sun; Yoon, Hyung-Koo; Lee, Jong-Sub

    2014-01-01

    Cement grouted soils, which consist of particulate soil media and cementation agents, have been widely used for the improvement of the strength and stiffness of weak ground and for the prevention of the leakage of ground water. The strength, elastic modulus, and Poisson's ratio of grouted soils have been determined by classical destructive methods. However, the performance of grouted soils depends on several parameters such as the distribution of particle size of the particulate soil media, grouting pressure, curing time, curing method, and ground water flow. In this study, elastic wave velocities are used to estimate the strength and elastic modulus, which are generally obtained by classical strength tests. Nondestructive tests by using elastic waves at small strain are conducted before and during classical strength tests at large strain. The test results are compared to identify correlations between the elastic wave velocity measured at small strain and strength and stiffness measured at large strain. The test results show that the strength and stiffness have exponential relationship with elastic wave velocities. This study demonstrates that nondestructive methods by using elastic waves may significantly improve the strength and stiffness evaluation processes of grouted soils. PMID:25025082

  10. Permeability dependency on stiff and compliant porosities: a model and some experimental examples

    NASA Astrophysics Data System (ADS)

    Shapiro, S. A.; Khizhniak, G. P.; Plotnikov, V. V.; Niemann, R.; Ilyushin, P. Yu; Galkin, S. V.

    2015-06-01

    The relation between porosity and permeability is not unique. We show that stress dependencies of both porosity and permeability can provide useful information clarifying this relation. We propose that comparison of the functional dependency of porosity and permeability on stress shows which part of the void space in rocks controls the permeability, the compliant porosity or the stiff porosity. The compliant porosity (including very thin cracks and grain-contact vicinities) usually controls the stress dependencies of elastic moduli of rocks. One then observes exponential-like dependencies of elastic properties on effective stress. Stress-induced deformation of stiff pores (equant pores) have less significance for stress dependencies of elastic properties on loadings of low to moderate magnitudes (several tens of MPa). However, such pores can play a significant role in the stress dependency of permeability. We propose a rather general model of permeability as a function of the stiff and compliant porosity. The model includes the possibility that, in different rocks, permeability can be controlled by stiff pores or, alternatively, by compliant pores, or, finally, by a combination of these. This model predicts a functional dependency of permeability on stress, ranging from power-law to exponential-law and to a mixed behavior of permeability in these situations, respectively. We show experimental results for four samples of sedimentary rocks from oil reservoirs of the Russian Perm region indicating these types of behavior.

  11. Decoupling the role of stiffness from other hydroxyapatite signalling cues in periosteal derived stem cell differentiation

    PubMed Central

    Mattei, Giorgio; Ferretti, Concetta; Tirella, Annalisa; Ahluwalia, Arti; Mattioli-Belmonte, Monica

    2015-01-01

    Bone extracellular matrix (ECM) is a natural composite made of collagen and mineral hydroxyapatite (HA). Dynamic cell-ECM interactions play a critical role in regulating cell differentiation and function. Understanding the principal ECM cues promoting osteogenic differentiation would be pivotal for both bone tissue engineering and regenerative medicine. Altering the mineral content generally modifies the stiffness as well as other physicochemical cues provided by composite materials, complicating the “cause-effect” analysis of resultant cell behaviour. To isolate the contribution of mechanical cues from other HA-derived signals, we developed and characterised composite HA/gelatin scaffolds with different mineral contents along with a set of stiffness-matched HA-free gelatin scaffolds. Samples were seeded with human periosteal derived progenitor cells (PDPCs) and cultured over 7 days, analysing their resultant morphology and gene expression. Our results show that both stiffness and HA contribute to directing PDPC osteogenic differentiation, highlighting the role of stiffness in triggering the expression of osteogenic genes and of HA in accelerating the process, particularly at high concentrations. PMID:26035412

  12. Transverse shear stiffness of laminated anisotropic shells

    NASA Technical Reports Server (NTRS)

    Cohen, G. A.

    1978-01-01

    Equations are derived for the transverse shear stiffness of laminated anisotropic shells. Without making assumptions for thickness distribution for either transverse shear stresses or strains, constitutive equations for the transverse shear deformation theory of anisotropic heterogeneous shells are found. The equations are based on Taylor series expansions about a generic point for stress resultants and couples, identically satisfying plate equilibrium equations. These equations are used to find statically correct expressions for in-surface stresses, transverse shear stresses, and the area density of transverse shear strain energy, in terms of transverse shear stress resultants and redundants. The application of Castigliano's theorem of least work minimizes shear strain energy with respect to the redundants. Examples are presented for several laminated walls. Good agreement is found between the results and those of exact three-dimensional elasticity solutions for the cylindrical bending of a plate.

  13. Stiffness of ? subunit of F(1)-ATPase.

    PubMed

    Okuno, Daichi; Iino, Ryota; Noji, Hiroyuki

    2010-11-01

    F(1)-ATPase is a molecular motor in which the ? subunit rotates inside the ?(3)?(3) ring upon adenosine triphosphate (ATP) hydrolysis. Recent works on single-molecule manipulation of F(1)-ATPase have shown that kinetic parameters such as the on-rate of ATP and the off-rate of adenosine diphosphate (ADP) strongly depend on the rotary angle of the ? subunit (Hirono-Hara et al. 2005; Iko et al. 2009). These findings provide important insight into how individual reaction steps release energy to power F(1) and also have implications regarding ATP synthesis and how reaction steps are reversed upon reverse rotation. An important issue regarding the angular dependence of kinetic parameters is that the angular position of a magnetic bead rotation probe could be larger than the actual position of the ? subunit due to the torsional elasticity of the system. In the present study, we assessed the stiffness of two different portions of F(1) from thermophilic Bacillus PS3: the internal part of the ? subunit embedded in the ?(3)?(3) ring, and the complex of the external part of the ? subunit and the ?(3)?(3) ring (and streptavidin and magnetic bead), by comparing rotational fluctuations before and after crosslinkage between the rotor and stator. The torsional stiffnesses of the internal and remaining parts were determined to be around 223 and 73 pNnm/radian, respectively. Based on these values, it was estimated that the actual angular position of the internal part of the ? subunit is one-fourth of the magnetic bead position upon stalling using an external magnetic field. The estimated elasticity also partially explains the accommodation of the intrinsic step size mismatch between F(o) and F(1)-ATPase. PMID:20549499

  14. Mechanically stiff, electrically conductive composites of polymers and carbon nanotubes

    DOEpatents

    Worsley, Marcus A.; Kucheyev, Sergei O.; Baumann, Theodore F.; Kuntz, Joshua D.; Satcher, Jr., Joe H.; Hamza, Alex V.

    2015-07-21

    Using SWNT-CA as scaffolds to fabricate stiff, highly conductive polymer (PDMS) composites. The SWNT-CA is immersing in a polymer resin to produce a SWNT-CA infiltrated with a polymer resin. The SWNT-CA infiltrated with a polymer resin is cured to produce the stiff and electrically conductive composite of carbon nanotube aerogel and polymer.

  15. Accelerated Stochastic Simulation of the Stiff Enzyme-Substrate Reaction

    E-print Network

    Cao, Yang

    1 Accelerated Stochastic Simulation of the Stiff Enzyme-Substrate Reaction Yang Cao a) Dept into a product is a common reaction motif in cellular chemical systems. In the three reactions that comprise constituents than to produce a product molecule. This condition makes the reaction set mathematically "stiff

  16. Leg stiffness of sprinters using running-specific prostheses

    E-print Network

    Herr, Hugh

    stiffness of the prosthesis coupled with differences in the limb posture required to run with the prosthesisLeg stiffness of sprinters using running-specific prostheses Craig P. McGowan1,*, Alena M, USA Running-specific prostheses (RSF) are designed to replicate the spring-like nature of biologi- cal

  17. Boundary Stiffness Regulates Fibroblast Behavior in Collagen Gels

    PubMed Central

    John, Jeffrey; Quinlan, Angela Throm; Silvestri, Chiara; Billiar, Kristen

    2010-01-01

    Recent studies have illustrated the profound dependence of cellular behavior on the stiffness of 2D culture substrates. The goal of this study was to develop a method to alter the stiffness cells experience in a standard 3D collagen gel model without affecting the physiochemical properties of the extracellular matrix. A device was developed utilizing compliant anchors (0.048–0.64 N m?1) to tune the boundary stiffness of suspended collagen gels in between the commonly utilized free and fixed conditions (zero and infinite stiffness boundary stiffness). We demonstrate the principle of operation with finite element analyses and a wide range of experimental studies. In all cases, boundary stiffness has a strong influence on cell behavior, most notably eliciting higher basal tension and activated force (in response to KCl) and more pronounced remodeling of the collagen matrix at higher boundary stiffness levels. Measured equibiaxial forces for gels seeded with 3 million human foreskin fibroblasts range from 0.05 to 1 mN increasing monotonically with boundary stiffness. Estimated force per cell ranges from 17 to 100 nN utilizing representative volume element analysis. This device provides a valuable tool to independently study the effect of the mechanical environment of the cell in a 3D collagen matrix. PMID:20012205

  18. Intra-abdominal pressure increases stiffness of the lumbar spine.

    PubMed

    Hodges, Paul W; Eriksson, A E Martin; Shirley, Debra; Gandevia, Simon C

    2005-09-01

    Intra-abdominal pressure (IAP) increases during many tasks and has been argued to increase stability and stiffness of the spine. Although several studies have shown a relationship between the IAP increase and spinal stability, it has been impossible to determine whether this augmentation of mechanical support for the spine is due to the increase in IAP or the abdominal muscle activity which contributes to it. The present study determined whether spinal stiffness increased when IAP increased without concurrent activity of the abdominal and back extensor muscles. A sustained increase in IAP was evoked by tetanic stimulation of the phrenic nerves either unilaterally or bilaterally at 20 Hz (for 5 s) via percutaneous electrodes in three subjects. Spinal stiffness was measured as the force required to displace an indentor over the L4 or L2 spinous process with the subjects lying prone. Stiffness was measured as the slope of the regression line fitted to the linear region of the force-displacement curve. Tetanic stimulation of the diaphragm increased IAP by 27-61% of a maximal voluntary pressure increase and increased the stiffness of the spine by 8-31% of resting levels. The increase in spinal stiffness was positively correlated with the size of the IAP increase. IAP increased stiffness at L2 and L4 level. The results of this study provide evidence that the stiffness of the lumbar spine is increased when IAP is elevated. PMID:16023475

  19. Differential Spring Stiffness Design for Finger Therapy Exercise Device

    E-print Network

    , middle and proximal phalanges and metacarpus. Suitable spring stiffness for DIP, PIP and MCP joints and proximal phalanges. Upon achieving desired posture, actuator was deactivated and the springs returned at distal, middle and proximal phalanges, coupled with differential spring stiffness design, allowed

  20. A parallel algorithm for generation and assembly of finite element stiffness and mass matrices

    NASA Technical Reports Server (NTRS)

    Storaasli, O. O.; Carmona, E. A.; Nguyen, D. T.; Baddourah, M. A.

    1991-01-01

    A new algorithm is proposed for parallel generation and assembly of the finite element stiffness and mass matrices. The proposed assembly algorithm is based on a node-by-node approach rather than the more conventional element-by-element approach. The new algorithm's generality and computation speed-up when using multiple processors are demonstrated for several practical applications on multi-processor Cray Y-MP and Cray 2 supercomputers.

  1. Passive mechanical models of fish caudal fins: effects of shape and stiffness on self-propulsion.

    PubMed

    Feilich, Kara L; Lauder, George V

    2015-06-01

    Fishes are found in a great variety of body forms with tail shapes that vary from forked tuna-like tails to the square-shaped tails found in some deep-bodied species. Hydrodynamic theory suggests that a fish's body and tail shape affects undulatory swimming performance. For example, a narrow caudal peduncle is believed to reduce drag, and a tuna-like tail to increase thrust. Despite the prevalence of these assertions, there is no experimental verification of the hydrodynamic mechanisms that may confer advantages on specific forms. Here, we use a mechanically-actuated flapping foil model to study how two aspects of shape, caudal peduncle depth and presence or absence of a forked caudal fin, may affect different aspects of swimming performance. Four different foil shapes were each made of plastics of three different flexural stiffnesses, permitting us to study how shape might interact with stiffness to produce swimming performance. For each foil, we measured the self-propelling swimming speed. In addition, we measured the forces, torques, cost of transport and power coefficient of each foil swimming at its self-propelling speed. There was no single 'optimal' foil exhibiting the highest performance in all metrics, and for almost all measures of swimming performance, foil shape and flexural stiffness interacted in complicated ways. Particle image velocimetry of several foils suggested that stiffness might affect the relative phasing of the body trailing edge and the caudal fin leading edge, changing the flow incident to the tail, and affecting hydrodynamics of the entire foil. The results of this study of a simplified model of fish body and tail morphology suggest that considerable caution should be used when inferring a swimming performance advantage from body and tail shape alone. PMID:25879846

  2. Spatial correlation coefficient images for ultrasonic detection.

    PubMed

    Cepel, Raina; Ho, K C; Rinker, Brett A; Palmer, Donald D; Lerch, Terrence P; Neal, Steven P

    2007-09-01

    In ultrasonics, image formation and detection are generally based on signal amplitude. In this paper, we introduce correlation coefficient images as a signal-amplitude independent approach for image formation. The correlation coefficients are calculated between A-scans digitized at adjacent measurement positions. In these images, defects are revealed as regions of high or low correlation relative to the background correlations associated with noise. Correlation coefficient and C-scan images are shown to demonstrate flat-bottom-hole detection in a stainless steel annular ring and crack detection in an aluminum aircraft structure. PMID:17941390

  3. SLE?: correlation functions in the coefficient problem

    NASA Astrophysics Data System (ADS)

    Loutsenko, Igor

    2012-07-01

    We apply the method of correlation functions to the coefficient problem in stochastic geometry. In particular, we give a proof for some universal patterns conjectured by M Zinsmeister for the second moments of the Taylor coefficients for special values of ? in the whole-plane Schramm-Loewner evolution (SLE?). We propose to use multi-point correlation functions for the study of higher moments in the coefficient problem. Generalizations related to the Levy-type processes are also considered. The exact integral means ?-spectrum of this version of the whole-plane SLE? is discussed.

  4. Characterization of the bending stiffness of large space structure joints

    NASA Technical Reports Server (NTRS)

    Wu, K. Chauncey

    1989-01-01

    A technique for estimating the bending stiffness of large space structure joints is developed and demonstrated for an erectable joint concept. Experimental load-deflection data from a three-point bending test was used as input to solve a closed-form expression for the joint bending stiffness which was derived from linear beam theory. Potential error sources in both the experimental and analytical procedures are identified and discussed. The bending stiffness of a mechanically preloaded erectable joint is studied at three applied moments and seven joint orientations. Using this technique, the joint bending stiffness was bounded between 6 and 17 percent of the bending stiffness of the graphite/epoxy strut member.

  5. Stiffness coupling application to modal synthesis program, users guide

    NASA Technical Reports Server (NTRS)

    Kuhar, E. J.

    1976-01-01

    A FORTRAN IV computer program used to perform modal synthesis of structures by stiffness coupling, using the dynamic transformation method is described. The program was named SCAMP (Stiffness Coupling Approach Modal-Synthesis Program). The program begins with the entry of a substructure's physical mode shapes and eigenvalues or a substructure's mass and stiffness matrix. If the mass and stiffness matrices are entered, the eigen problem for the individual substructure is solved. Provisions are included for a maximum of 20 substructures which are coupled by stiffness matrix springs. Each substructure has a number degrees of freedom (DOF), except that for DOF greater than 100; vector sets having maximum row and column size of 100 were generated prior to entering SCAMP. The substructures are then coupled together via coupling springs, and the dynamic transformation is used to reduce the size of the eigen problem.

  6. Arterial Stiffness in Children: Pediatric Measurement and Considerations

    PubMed Central

    Savant, Jonathan D.; Furth, Susan L.; Meyers, Kevin E.C.

    2014-01-01

    Background Arterial stiffness is a natural consequence of aging, accelerated in certain chronic conditions, and predictive of cardiovascular events in adults. Emerging research suggests the importance of arterial stiffness in pediatric populations. Methods There are different indices of arterial stiffness. The present manuscript focuses on carotid-femoral pulse wave velocity and pulse wave analysis, although other methodologies are discussed. Also reviewed are specific measurement considerations for pediatric populations and the literature describing arterial stiffness in children with certain chronic conditions (primary hypertension, obesity, diabetes, chronic kidney disease, hypercholesterolemia, genetic syndromes involving vasculopathy, and solid organ transplant recipients). Conclusions The measurement of arterial stiffness in children is feasible and, under controlled conditions, can give accurate information about the underlying state of the arteries. This potentially adds valuable information about the functionality of the cardiovascular system in children with a variety of chronic diseases well beyond that of the brachial artery blood pressure.

  7. An experimental nonlinear low dynamic stiffness device for shock isolation

    NASA Astrophysics Data System (ADS)

    Francisco Ledezma-Ramirez, Diego; Ferguson, Neil S.; Brennan, Michael J.; Tang, Bin

    2015-07-01

    The problem of shock generated vibration is very common in practice and difficult to isolate due to the high levels of excitation involved and its transient nature. If not properly isolated it could lead to large transmitted forces and displacements. Typically, classical shock isolation relies on the use of passive stiffness elements to absorb energy by deformation and some damping mechanism to dissipate residual vibration. The approach of using nonlinear stiffness elements is explored in this paper, focusing in providing an isolation system with low dynamic stiffness. The possibilities of using such a configuration for a shock mount are studied experimentally following previous theoretical models. The model studied considers electromagnets and permanent magnets in order to obtain nonlinear stiffness forces using different voltage configurations. It is found that the stiffness nonlinearities could be advantageous in improving shock isolation in terms of absolute displacement and acceleration response when compared with linear elastic elements.

  8. ORFEUS CFRP structure: A high stiffness-low thermal strain space telescope structure

    NASA Astrophysics Data System (ADS)

    Schaeffler, Thomas

    1991-10-01

    ORFEUS (Orbiting and Retrievable Far and Extreme Ultraviolet Spectrometer) is a 1 m diameter telescope to be integrated into the ASTRO-SPAS satellite on one of its missions. ORFEUS is to be launched in 1992 for a 7 day mission on the Space Shuttle. Design constraints to be respected during the development of the tube shaped structure with 4 m length and 1.1 m inner diameter were: lowest coefficient of thermal expansion, high stiffness, low outgassing rates and low mass. These constraints led to a filament wound tube stiffened on the outer side with autoclave cured CFRP (Carbon Fiber Reinforced Plastic) profiles. Material used is a high modulus carbon fiber in combination with epoxy resin. Flanges and other interfaces are mainly made of a low coefficient of thermal expansion nickel iron alloy Invar. An Invar foil covers the inner surface of the tube to restrict outgassing.

  9. A Treatise on Equivalent-Plate Stiffnesses for Stiffened Laminated-Composite Plates and Plate-Like Lattices

    NASA Technical Reports Server (NTRS)

    Nemeth, Michael P.

    2011-01-01

    A survey of studies conducted since 1914 on the use of equivalent-plate stiffnesses in modeling the overall, stiffness-critical response of stiffened plates and shells is presented. Two detailed, comprehensive derivations of first-approximation equivalent-plate stiffnesses are also presented that are based on the Reissner-Mindlin-type, first-order transverse-shear deformation theory for anisotropic plates. Equivalent-plate stiffness expressions, and a corresponding symbolic manipulation computer program, are also presented for several different stiffener configurations. These expressions are very general and exhibit the full range of anisotropies permitted by the Reissner-Mindlin-type, first-order transverse-shear deformation theory for anisotropic plates. The expressions presented in the present study were also compared with available, previously published results. For the most part, the previously published results are for special cases of the general expressions presented herein and are almost in complete agreement. Analysis is also presented that extends the use of the equivalent-plate stiffness expressions to sandwich plates.

  10. An experimental and theoretical comparison of rotordynamic coefficients for sawtooth-pattern damper seals. M.S. Thesis

    NASA Technical Reports Server (NTRS)

    Nolan, Steven Anthony

    1987-01-01

    A brief review of the annular seal theory as related to rotordynamics for liquid seals is presented. Also included is an overview of Childs and Kim's current theory for calculating empirical turbulence coefficients and predicting stiffness and damping coefficients for surface roughened damper seals. The designation sawtooth-pattern refers to a seal stator with a roughness pattern whose cross section normal to the seal axis resembles a sawtooth with the teeth directed against the flow. The net stiffness and damping coefficients for the eleven seals are compared to each other, a smooth seal, and the optimum-configuration damper seal previously tested. The experimental force coefficients, the net damping, and the net stiffness coefficients for four of the sawtooth seals are compared to the predictions of Childs and Kim's analysis. The sawtooth-pattern seal had less net damping than the hole-pattern seal but more than the smooth seal. The stiffness was comparable to the hole-pattern. Both the sawtooth and hole-pattern seals leaked less than the smooth seal, while the sawtooth-pattern seal with maximum damping leaked more than the hole-pattern seal. The theoretical predictions compared relatively poorly to the experimental results obtained for the rotordynamic coefficients of the seals investigation.

  11. The Focal Adhesion: A Regulated Component of Aortic Stiffness

    PubMed Central

    Saphirstein, Robert J.; Gao, Yuan Z.; Jensen, Mikkel H.; Gallant, Cynthia M.; Vetterkind, Susanne; Moore, Jeffrey R.; Morgan, Kathleen G.

    2013-01-01

    Increased aortic stiffness is an acknowledged predictor and cause of cardiovascular disease. The sources and mechanisms of vascular stiffness are not well understood, although the extracellular matrix (ECM) has been assumed to be a major component. We tested here the hypothesis that the focal adhesions (FAs) connecting the cortical cytoskeleton of vascular smooth muscle cells (VSMCs) to the matrix in the aortic wall are a component of aortic stiffness and that this component is dynamically regulated. First, we examined a model system in which magnetic tweezers could be used to monitor cellular cortical stiffness, serum-starved A7r5 aortic smooth muscle cells. Lysophosphatidic acid (LPA), an activator of myosin that increases cell contractility, increased cortical stiffness. A small molecule inhibitor of Src-dependent FA recycling, PP2, was found to significantly inhibit LPA-induced increases in cortical stiffness, as well as tension-induced increases in FA size. To directly test the applicability of these results to force and stiffness development at the level of vascular tissue, we monitored mouse aorta ring stiffness with small sinusoidal length oscillations during agonist-induced contraction. The alpha-agonist phenylephrine, which also increases myosin activation and contractility, increased tissue stress and stiffness in a PP2- and FAK inhibitor 14-attenuated manner. Subsequent phosphotyrosine screening and follow-up with phosphosite-specific antibodies confirmed that the effects of PP2 and FAK inhibitor 14 in vascular tissue involve FA proteins, including FAK, CAS, and paxillin. Thus, in the present study we identify, for the first time, the FA of the VSMC, in particular the FAK-Src signaling complex, as a significant subcellular regulator of aortic stiffness and stress. PMID:23626821

  12. Leg stiffness adjustment during hopping at different intensities and frequencies.

    PubMed

    Mrdakovic, Vladimir; Ilic, Dusko; Vulovic, Radun; Matic, Milan; Jankovic, Nenad; Filipovic, Nenad

    2014-01-01

    Understanding leg and joint stiffness adjustment during maximum hopping may provide important information for developing more effective training methods. It has been reported that ankle stiffness has major influence on stable spring-mass dynamics during submaximal hopping, and that knee stiffness is a major determinant for hopping performance during maximal hopping task. Furthermore, there are no reports on how the height of the previous hop could affect overall stiffness modulation of the subsequent maximum one. The purpose of the present study was to determine whether and how the jump height of the previous hop affects leg and joint stiffness for subsequent maximum hop. Ten participants completed trials in which they repeatedly hopped as high as possible (MX task) and trials in which they were instructed to perform several maximum hops with 3 preferred (optimal) height hops between each of them (P3MX task). Both hopping tasks were performed at 2.2 Hz hopping frequency and at the participant's preferred (freely chosen) frequency as well. By comparing results of those hopping tasks, we found that ankle stiffness at 2.2 Hz ( p = 0.041) and knee stiffness at preferred frequency ( p = 0.045) was significantly greater for MX versus P3MX tasks. Leg stiffness for 2.2 Hz hopping is greater than for the preferred frequency. Ankle stiffness is greater for 2.2 Hz than for preferred frequencies; opposite stands for knee stiffness. The results of this study suggest that preparatory hop height can be considered as an important factor for modulation of maximum hop. PMID:25308379

  13. Measuring Seebeck Coefficient

    NASA Technical Reports Server (NTRS)

    Snyder, G. Jeffrey (Inventor)

    2015-01-01

    A high temperature Seebeck coefficient measurement apparatus and method with various features to minimize typical sources of errors is described. Common sources of temperature and voltage measurement errors which may impact accurate measurement are identified and reduced. Applying the identified principles, a high temperature Seebeck measurement apparatus and method employing a uniaxial, four-point geometry is described to operate from room temperature up to 1300K. These techniques for non-destructive Seebeck coefficient measurements are simple to operate, and are suitable for bulk samples with a broad range of physical types and shapes.

  14. Bounce scenarios in the Sotiriou-Visser-Weinfurtner generalization of the projectable Horava-Lifshitz gravity

    E-print Network

    Ewa Czuchry

    2011-05-14

    The occurrence of a bounce in the FRW cosmology requires modifications of General Relativity. An example of such a modification is the recently proposed Horava-Lifshitz theory of gravity, which includes a "dark radiation" term with a negative coefficient in the analog of the Friedmann equation. A modification of the HL gravity, relaxing the "detailed balance" condition, brings additional terms to the equations of motion, corresponding to stiff matter. This paper presents comparison of the phase structure of the original and modified Horava cosmology. Special attention is paid to the analysis of a wide range of bouncing solution, appearing in both versions of the Horava theory.

  15. Arterial stiffness and endothelial inflammation in prediabetes and newly diagnosed diabetes patients.

    PubMed

    Çakar, Mustafa; Balta, ?evket; ?arlak, Hakan; Akhan, Muharrem; Demirkol, Sait; Karaman, Murat; Ay, Seyit Ahmet; Kurt, Ömer; Çayci, Tuncer; ?nal, Sat?lm??; Demirba?, ?eref

    2015-10-01

    ObjectiveThere is a growing body of data supporting the association between diabetes and microcirculatory disfunction. We aimed to study e-selectin levels, and their associations with serum markers of inflammation and arterial stiffness in prediabetes and newly diagnosed diabetes patients in this study.Subjects and methodsSixty patients (25 females) with a newly established elevated fasting serum glucose [20 impaired fasting glucose (IFG), 20 impaired glucose tolerance (IGT), 20 newly diagnosed diabetes (T2DM)] and 17 healthy controls (13 females) were included in the study. Serum e-selectin and hs-CRP levels, and arterial stiffness parameters of the patients were studied.ResultsFasting serum glucose was the most important predictor of serum e-selectin levels. Pulse wave velocity and central aortic pressures were significantly higher in IFG, IGT and T2DM groups, compared to controls (p = 0.001, < 0.001, 0.013 and 0.015, 0.002, 0.009, respectively). The mean arterial pressure did not show any significant association with serum e-selectin and hs-CRP levels (? coefficient: 0.092, p = 0.358; and ? coefficient: 0.189, p = 0.362, respectively).ConclusionPrediabetes patients have increasing e-selectin levels through the diagnosis of T2DM. E-selectin is associated with serum glucose levels. Prediabetic and newly diagnosed diabetics have higher arterial stiffness measurements. Serum e-selectin may be a good marker of endothelial inflammation and dysfunction increasing in parallel with serum glucose levels, predicting future cardiovascular events. PMID:26201008

  16. Stiffness characteristics of airfoils under pulse loading

    NASA Astrophysics Data System (ADS)

    Turner, Kevin Eugene

    The turbomachinery industry continually struggles with the adverse effects of contact rubs between airfoils and casings. The key parameter controlling the severity of a given rub event is the contact load produced when the airfoil tips incur into the casing. These highly non-linear and transient forces are difficult to calculate and their effects on the static and rotating components are not well understood. To help provide this insight, experimental and analytical capabilities have been established and exercised through an alliance between GE Aviation and The Ohio State University Gas Turbine Laboratory. One of the early findings of the program is the influence of blade flexibility on the physics of rub events. The core focus of the work presented in this dissertation is to quantify the influence of airfoil flexibility through a novel modeling approach that is based on the relationship between applied force duration and maximum tip deflection. This relationship is initially established using a series of forward, non-linear and transient analyses in which simulated impulse rub loads are applied. This procedure, although effective, is highly inefficient and costly to conduct by requiring numerous explicit simulations. To alleviate this issue, a simplified model, named the pulse magnification model, is developed that only requires a modal analysis and a static analyses to fully describe how the airfoil stiffness changes with respect to load duration. Results from the pulse magnification model are compared to results from the full transient simulation method and to experimental results, providing sound verification for the use of the modeling approach. Furthermore, a unique and highly efficient method to model airfoil geometries was developed and is outlined in this dissertation. This method produces quality Finite Element airfoil definitions directly from a fully parameterized mathematical model. The effectiveness of this approach is demonstrated by comparing modal properties of the simulated geometries to modal properties of various current airfoil designs. Finally, this modeling approach was used in conjunction with the pulse magnification model to study the effects of various airfoil geometric features on the stiffness of the blade under impulsive loading.

  17. Estimation of quasi-stiffness and propulsive work of the human ankle in the stance phase of walking.

    PubMed

    Shamaei, Kamran; Sawicki, Gregory S; Dollar, Aaron M

    2013-01-01

    Characterizing the quasi-stiffness and work of lower extremity joints is critical for evaluating human locomotion and designing assistive devices such as prostheses and orthoses intended to emulate the biological behavior of human legs. This work aims to establish statistical models that allow us to predict the ankle quasi-stiffness and net mechanical work for adults walking on level ground. During the stance phase of walking, the ankle joint propels the body through three distinctive phases of nearly constant stiffness known as the quasi-stiffness of each phase. Using a generic equation for the ankle moment obtained through an inverse dynamics analysis, we identify key independent parameters needed to predict ankle quasi-stiffness and propulsive work and also the functional form of each correlation. These parameters include gait speed, ankle excursion, and subject height and weight. Based on the identified form of the correlation and key variables, we applied linear regression on experimental walking data for 216 gait trials across 26 subjects (speeds from 0.75-2.63 m/s) to obtain statistical models of varying complexity. The most general forms of the statistical models include all the key parameters and have an R(2) of 75% to 81% in the prediction of the ankle quasi-stiffnesses and propulsive work. The most specific models include only subject height and weight and could predict the ankle quasi-stiffnesses and work for optimal walking speed with average error of 13% to 30%. We discuss how these models provide a useful framework and foundation for designing subject- and gait-specific prosthetic and exoskeletal devices designed to emulate biological ankle function during level ground walking. PMID:23555839

  18. Effect of ECM Stiffness on Integrin-Ligand Binding Strength

    NASA Astrophysics Data System (ADS)

    Thomas, Gawain; Wen, Qi

    2014-03-01

    Many studies have shown that cells respond to the stiffness of their extracellular matrix (ECM). However, the mechanism of this stiffness sensing is not fully understood. We believe that cells probe stiffness by applying intracellular force to the ECM via the integrin-mediated adhesions. The linkage of integrins to the cytoskeleton has been modeled as a slip clutch, which has been shown to affect focal adhesion formation and hence force transmission in a stiffness dependent manner. In contrast, the bonds between integrins and ECM have been characterized as ``catch bonds.'' It is unclear how ECM viscoelasticity affects these catch bonds. We report, for the first time, the effects of ECM stiffness on the binding strength of integrins to ECM ligands by measuring the rupture force of individual integrin-ligand bonds of cells on collagen-coated polyacrylamide gels. Results show that the integrin-collagen bonds of 3T3 fibroblasts are nearly four times stronger on a stiff (30 kPa) gel than on a soft (3 kPa) gel. The stronger integrin bonds on stiffer substrates can promote focal adhesion formation. This suggests that the substrate stiffness regulates the cell-ECM adhesions not only by affecting the cytoskeleton-integrin links but also by modulating the binding of integrins to the ECM.

  19. Use of Guided Acoustic Waves to Assess the Effects of Thermal-Mechanical Cycling on Composite Stiffness

    NASA Technical Reports Server (NTRS)

    Seale, Michael D.; Madaras, Eric I.

    2000-01-01

    The introduction of new, advanced composite materials into aviation systems requires it thorough understanding of the long-term effects of combined thermal and mechanical loading. As part of a study to evaluate the effects of thermal-mechanical cycling, it guided acoustic (Lamb) wave measurement system was used to measure the bending and out-of-plane stiffness coefficients of composite laminates undergoing thermal-mechanical loading. The system uses a pulse/receive technique that excites an antisymmetric Lamb mode and measures the time-of-flight over a wide frequency range. Given the material density and plate thickness, the bending and out-of-plane shear stiffnesses are calculated from a reconstruction of the velocity dispersion curve. A series of 16 and 32-ply composite laminates were subjected to it thermal-mechanical loading profile in load frames equipped with special environmental chambers. The composite systems studied were it graphite fiber reinforced amorphous thermoplastic polyimide and it graphite fiber reinforced bismaleimide thermoset. The samples were exposed to both high and low temperature extremes its well as high and low strain profiles. The bending and out-of-plane stiffnesses for composite sample that have undergone over 6,000 cycles of thermal-mechanical loading are reported. The Lamb wave generated elastic stiffness results have shown decreases of up to 20% at 4,936 loading cycles for the graphite/thermoplastic samples and up to 64% at 4,706 loading cycles for the graphite/thermoset samples.

  20. Charts relating the compressive buckling stress of longitudinally supported plates to the effective deflectional and rotational stiffness of the supports

    NASA Technical Reports Server (NTRS)

    Anderson, Roger A; Semonian, Joseph W

    1954-01-01

    A stability analysis is made of a long flat rectangular plate subjected to a uniform longitudinal compressive stress and supported along its longitudinal edges and along one or more longitudinal lines by elastic line supports. The elastic supports possess deflectional and rotational stiffness. Such configuration is an idealization of the compression cover skin and internal structure of a wing and tail surfaces. The results of the analysis are presented in the form of charts in which the buckling-stress coefficient is plotted against the buckle length of the plate for a wide range of support stiffnesses. The charts make possible the determination of the compressive buckling stress of plates supported by members whose stiffness may or may not be defined by elementary beam bending and twisting theory but yet whose effective restraint is amenable to evaluation. The deflectional and rotational stiffness provided by longitudinal stiffeners and full-depth webs is discussed and numerical examples are given to illustrate the application of the charts to the design of wing structures.

  1. Biomechanical constraints on the feedforward regulation of endpoint stiffness

    PubMed Central

    Murray, Wendy M.; Perreault, Eric J.

    2012-01-01

    Although many daily tasks tend to destabilize arm posture, it is still possible to have stable interactions with the environment by regulating the multijoint mechanics of the arm in a task-appropriate manner. For postural tasks, this regulation involves the appropriate control of endpoint stiffness, which represents the stiffness of the arm at the hand. Although experimental studies have been used to evaluate endpoint stiffness control, including the orientation of maximal stiffness, the underlying neural strategies remain unknown. Specifically, the relative importance of feedforward and feedback mechanisms has yet to be determined due to the difficulty separately identifying the contributions of these mechanisms in human experiments. This study used a previously validated three-dimensional musculoskeletal model of the arm to quantify the degree to which the orientation of maximal endpoint stiffness could be changed using only steady-state muscle activations, used to represent feedforward motor commands. Our hypothesis was that the feedforward control of endpoint stiffness orientation would be significantly constrained by the biomechanical properties of the musculoskeletal system. Our results supported this hypothesis, demonstrating substantial biomechanical constraints on the ability to regulate endpoint stiffness throughout the workspace. The ability to regulate stiffness orientation was further constrained by additional task requirements, such as the need to support the arm against gravity or exert forces on the environment. Together, these results bound the degree to which slowly varying feedforward motor commands can be used to regulate the orientation of maximum arm stiffness and provide a context for better understanding conditions in which feedback control may be needed. PMID:22832565

  2. Impact of blood pressure perturbations on arterial stiffness.

    PubMed

    Lim, Jisok; Pearman, Miriam E; Park, Wonil; Alkatan, Mohammed; Machin, Daniel R; Tanaka, Hirofumi

    2015-12-15

    Although the associations between chronic levels of arterial stiffness and blood pressure (BP) have been fairly well studied, it is not clear whether and how much arterial stiffness is influenced by acute perturbations in BP. The primary aim of this study was to determine magnitudes of BP dependence of various measures of arterial stiffness during acute BP perturbation maneuvers. Fifty apparently healthy subjects, including 25 young (20-40 yr) and 25 older adults (60-80 yr), were studied. A variety of BP perturbations, including head-up tilt, head-down tilt, mental stress, isometric handgrip exercise, and cold pressor test, were used to encompass BP changes induced by physical, mental, and/or mechanical stimuli. When each index of arterial stiffness was plotted with mean BP, all arterial stiffness indices, including cardio-ankle vascular index or CAVI (r = 0.50), carotid-femoral pulse wave velocity or cfPWV (r = 0.51), brachial-ankle pulse wave velocity or baPWV (r = 0.61), arterial compliance (r = -0.42), elastic modulus (r = 0.52), arterial distensibility (r = -0.32), ?-stiffness index (r = 0.19), and Young's modulus (r = 0.35) were related to mean BP (all P < 0.01). Changes in CAVI, cfPWV, baPWV, and elastic modulus were significantly associated with changes in mean BP in the pooled conditions, while changes in arterial compliance, arterial distensibility, ?-stiffness index, and Young's modulus were not. In conclusion, this study demonstrated that BP changes in response to various forms of pressor stimuli were associated with the corresponding changes in arterial stiffness indices and that the strengths of associations with BP varied widely depending on what arterial stiffness indices were examined. PMID:26468262

  3. Local Rank Inference for Varying Coefficient Models.

    PubMed

    Wang, Lan; Kai, Bo; Li, Runze

    2009-12-01

    By allowing the regression coefficients to change with certain covariates, the class of varying coefficient models offers a flexible approach to modeling nonlinearity and interactions between covariates. This paper proposes a novel estimation procedure for the varying coefficient models based on local ranks. The new procedure provides a highly efficient and robust alternative to the local linear least squares method, and can be conveniently implemented using existing R software package. Theoretical analysis and numerical simulations both reveal that the gain of the local rank estimator over the local linear least squares estimator, measured by the asymptotic mean squared error or the asymptotic mean integrated squared error, can be substantial. In the normal error case, the asymptotic relative efficiency for estimating both the coefficient functions and the derivative of the coefficient functions is above 96%; even in the worst case scenarios, the asymptotic relative efficiency has a lower bound 88.96% for estimating the coefficient functions, and a lower bound 89.91% for estimating their derivatives. The new estimator may achieve the nonparametric convergence rate even when the local linear least squares method fails due to infinite random error variance. We establish the large sample theory of the proposed procedure by utilizing results from generalized U-statistics, whose kernel function may depend on the sample size. We also extend a resampling approach, which perturbs the objective function repeatedly, to the generalized U-statistics setting; and demonstrate that it can accurately estimate the asymptotic covariance matrix. PMID:20657760

  4. Notes 14. Experimental identification of bearing force coefficients 

    E-print Network

    San Andres, Luis

    2009-01-01

    of a High Speed Reynolds Number Hydrostatic Bearing,? ASME Journal of Vibration and Acoustics, Vol. 115, pp. 264-270. Instrumental Variable Filter Method Fritzen, C. P., 1985, ?Identification of Mass, Damping, and Stiffness Matrices of Mechanical... OF BEARING FORCE COEFFICIENTS. ? Dr. Luis San Andr?s (2009) 5 Consider a test bearing or seal element as a point mass undergoing forced vibrations induced by external forcing functions. K XX , C XX bearing X K XY , C XY K YX , C YX K YY , C YY...

  5. Symmetry energy coefficients for asymmetric nuclear matter

    E-print Network

    Fábio L. Braghin

    2003-12-16

    Symmetry energy coefficients of asymmetric nuclear matter are investigated as the inverse of nuclear matter polarizabilities with two different approaches. Firstly a general calculation shows they may depend on the neutron-proton asymmetry itself. The choice of particular prescriptions for the density fluctuations lead to certain isospin (n-p asymmetry) dependences of the polarizabilities. Secondly, with Skyrme type interactions, the static limit of the dynamical polarizability is investigated corresponding to the inverse symmetry energy coefficient which assumes different values at different asymmetries (and densities and temperatures). The symmetry energy coefficient (in the isovector channel) is found to increase as n-p asymmetries increase. The spin symmetry energy coefficient is also briefly investigated.

  6. Second-order bounds for linear recurrences with negative coefficients

    NASA Astrophysics Data System (ADS)

    Berenhaut, Kenneth S.; Morton, Daniel C.

    2006-02-01

    This paper introduces a generalization of Fibonacci and Pell polynomials in order to obtain optimal second-order bounds for general linear recurrences with negative coefficients. An important aspect of the derived bounds is that they are applicable and easily computable. The results imply bounds on all entries in inverses of triangular matrices as well as on coefficients of reciprocals of power series.

  7. Modeling, Modal Properties, and Mesh Stiffness Variation Instabilities of Planetary Gears

    NASA Technical Reports Server (NTRS)

    Parker, Robert G.; Lin, Jian; Krantz, Timothy L. (Technical Monitor)

    2001-01-01

    Planetary gear noise and vibration are primary concerns in their applications in helicopters, automobiles, aircraft engines, heavy machinery and marine vehicles. Dynamic analysis is essential to the noise and vibration reduction. This work analytically investigates some critical issues and advances the understanding of planetary gear dynamics. A lumped-parameter model is built for the dynamic analysis of general planetary gears. The unique properties of the natural frequency spectra and vibration modes are rigorously characterized. These special structures apply for general planetary gears with cyclic symmetry and, in practically important case, systems with diametrically opposed planets. The special vibration properties are useful for subsequent research. Taking advantage of the derived modal properties, the natural frequency and vibration mode sensitivities to design parameters are investigated. The key parameters include mesh stiffnesses, support/bearing stiffnesses, component masses, moments of inertia, and operating speed. The eigen-sensitivities are expressed in simple, closed-form formulae associated with modal strain and kinetic energies. As disorders (e.g., mesh stiffness variation. manufacturing and assembling errors) disturb the cyclic symmetry of planetary gears, their effects on the free vibration properties are quantitatively examined. Well-defined veering rules are derived to identify dramatic changes of natural frequencies and vibration modes under parameter variations. The knowledge of free vibration properties, eigen-sensitivities, and veering rules provide important information to effectively tune the natural frequencies and optimize structural design to minimize noise and vibration. Parametric instabilities excited by mesh stiffness variations are analytically studied for multi-mesh gear systems. The discrepancies of previous studies on parametric instability of two-stage gear chains are clarified using perturbation and numerical methods. The operating conditions causing parametric instabilities are expressed in closed-form suitable for design guidance. Using the well-defined modal properties of planetary gears, the effects of mesh parameters on parametric instability are analytically identified. Simple formulae are obtained to suppress particular instabilities by adjusting contact ratios and mesh phasing.

  8. Micropipette Aspiration of Substrate-attached Cells to Estimate Cell Stiffness

    PubMed Central

    Oh, Myung-Jin; Kuhr, Frank; Byfield, Fitzroy; Levitan, Irena

    2012-01-01

    Growing number of studies show that biomechanical properties of individual cells play major roles in multiple cellular functions, including cell proliferation, differentiation, migration and cell-cell interactions. The two key parameters of cellular biomechanics are cellular deformability or stiffness and the ability of the cells to contract and generate force. Here we describe a quick and simple method to estimate cell stiffness by measuring the degree of membrane deformation in response to negative pressure applied by a glass micropipette to the cell surface, a technique that is called Micropipette Aspiration or Microaspiration. Microaspiration is performed by pulling a glass capillary to create a micropipette with a very small tip (2-50 ?m diameter depending on the size of a cell or a tissue sample), which is then connected to a pneumatic pressure transducer and brought to a close vicinity of a cell under a microscope. When the tip of the pipette touches a cell, a step of negative pressure is applied to the pipette by the pneumatic pressure transducer generating well-defined pressure on the cell membrane. In response to pressure, the membrane is aspirated into the pipette and progressive membrane deformation or "membrane projection" into the pipette is measured as a function of time. The basic principle of this experimental approach is that the degree of membrane deformation in response to a defined mechanical force is a function of membrane stiffness. The stiffer the membrane is, the slower the rate of membrane deformation and the shorter the steady-state aspiration length.The technique can be performed on isolated cells, both in suspension and substrate-attached, large organelles, and liposomes. Analysis is performed by comparing maximal membrane deformations achieved under a given pressure for different cell populations or experimental conditions. A "stiffness coefficient" is estimated by plotting the aspirated length of membrane deformation as a function of the applied pressure. Furthermore, the data can be further analyzed to estimate the Young's modulus of the cells (E), the most common parameter to characterize stiffness of materials. It is important to note that plasma membranes of eukaryotic cells can be viewed as a bi-component system where membrane lipid bilayer is underlied by the sub-membrane cytoskeleton and that it is the cytoskeleton that constitutes the mechanical scaffold of the membrane and dominates the deformability of the cellular envelope. This approach, therefore, allows probing the biomechanical properties of the sub-membrane cytoskeleton. PMID:23051713

  9. Arterial stiffness in periodontitis patients and controls.

    PubMed

    Houcken, W; Teeuw, W J; Bizzarro, S; Alvarez Rodriguez, E; Mulders, T A; van den Born, B-Jh; Loos, B G

    2016-01-01

    Increased arterial stiffness (AS) is an important indicator for atherosclerotic cardiovascular disease (ACVD). Epidemiologically, periodontitis and ACVD are associated. Therefore, we aimed to investigate AS in periodontitis patients and controls. In addition, we explored the effect of periodontal therapy on AS in a sub-group of cases. Pulse-wave velocity (PWV), a non-invasive chair-side function test for AS, was measured in periodontitis patients (n=57; mean age 46.6 years) and compared with a reference group (n=48; mean age 45.5 years). In addition, 45 cases (mean age 46.9 years) were 6 months followed after periodontal treatment, to explore a possible effect on arterial function. Periodontitis patients showed a significantly increased PWV compared with the reference group (8.01±0.20 vs 7.36±0.22?m?s(-1) respectively; P=0.029) and this remained significant after adjustments for ACVD risk factors (P=0.019). After periodontal therapy, no significant reduction in PWV was seen (8.00±1.8 to 7.82±1.6?m?s(-1); P=0.13), but systolic blood pressure (SBP) was significantly reduced (119.8±14.6 to 116.9±15.1?mm?Hg; P=0.040). It can be concluded that periodontitis is associated with increased AS. This confirms with a new parameter the association of periodontitis with ACVD. Although periodontal treatment did not lower AS significantly, a modest reduction of SBP after 6 months was observed. PMID:25972093

  10. Effective Spring Stiffness for a Planar Periodic Array of Collinear Cracks at an Interface between Two Dissimilar Isotropic Materials

    PubMed Central

    Lekesiz, Huseyin; Katsube, Noriko; Rokhlin, Stanislav I.; Seghi, Robert R.

    2011-01-01

    Explicit analytical expressions are obtained for the longitudinal and transverse effective spring stiffnesses of a planar periodic array of collinear cracks at the interface between two dissimilar isotropic materials; they are shown to be identical in a general case of elastic dissimilarity (the well-known open interface crack model is employed for the solution). Since the interfacial spring stiffness can be experimentally determined from ultrasound reflection and transmission analysis, the proposed expressions can be useful in estimating the percentage of disbond area between two dissimilar materials, which is directly related to the residual strength of the interface. The effects of elastic dissimilarity, crack density and crack interaction on the effective spring stiffness are clearly represented in the solution. It is shown that in general the crack interaction weakly depends on material dissimilarity and, for most practical cases, the crack interaction is nearly the same as that for crack arrays between identical solids. This allows approximate factorization of the effective spring stiffness for an array of cracks between dissimilar materials in terms of an elastic dissimilarity factor and two factors obtained for cracks in a homogeneous material: the effective spring stiffness for non-interacting (independent) cracks and the crack interaction factor. In order to avoid the effect of the crack surface interpenetration zones on the effective spring stiffness, the range of the tensile to transverse load ratios is obtained under the assumption of small-scale contact conditions. Since real cracks are often slightly open (due to prior loading history and plastic deformation), it is demonstrated that for ultrasound applications the results obtained are valid for most practical cases of small interfacial cracks as long as the mid-crack opening normalized by the crack length is at least in the order of 10?5. PMID:23710104

  11. Improved Equivalent Linearization Implementations Using Nonlinear Stiffness Evaluation

    NASA Technical Reports Server (NTRS)

    Rizzi, Stephen A.; Muravyov, Alexander A.

    2001-01-01

    This report documents two new implementations of equivalent linearization for solving geometrically nonlinear random vibration problems of complicated structures. The implementations are given the acronym ELSTEP, for "Equivalent Linearization using a STiffness Evaluation Procedure." Both implementations of ELSTEP are fundamentally the same in that they use a novel nonlinear stiffness evaluation procedure to numerically compute otherwise inaccessible nonlinear stiffness terms from commercial finite element programs. The commercial finite element program MSC/NASTRAN (NASTRAN) was chosen as the core of ELSTEP. The FORTRAN implementation calculates the nonlinear stiffness terms and performs the equivalent linearization analysis outside of NASTRAN. The Direct Matrix Abstraction Program (DMAP) implementation performs these operations within NASTRAN. Both provide nearly identical results. Within each implementation, two error minimization approaches for the equivalent linearization procedure are available - force and strain energy error minimization. Sample results for a simply supported rectangular plate are included to illustrate the analysis procedure.

  12. Torque-stiffness-controlled dynamic walking with central pattern generators.

    PubMed

    Huang, Yan; Vanderborght, Bram; Van Ham, Ronald; Wang, Qining

    2014-12-01

    Walking behavior is modulated by controlling joint torques in most existing passivity-based bipeds. Controlled Passive Walking with adaptable stiffness exhibits controllable natural motions and energy efficient gaits. In this paper, we propose torque-stiffness-controlled dynamic bipedal walking, which extends the concept of Controlled Passive Walking by introducing structured control parameters and a bio-inspired control method with central pattern generators. The proposed walking paradigm is beneficial in clarifying the respective effects of the external actuation and the internal natural dynamics. We present a seven-link biped model to validate the presented walking. Effects of joint torque and joint stiffness on gait selection, walking performance and walking pattern transitions are studied in simulations. The work in this paper develops a new solution of motion control of bipedal robots with adaptable stiffness and provides insights of efficient and sophisticated walking gaits of humans. PMID:25128320

  13. Stiffness mapping of compliant parallel mechanisms in a serial arrangement

    E-print Network

    Florida, University of

    Stiffness mapping of compliant parallel mechanisms in a serial arrangement Hyun K. Jung a , Carl D.: +1 352 392 9461; fax: +1 352 392 1071. E-mail addresses: hyunkwon.jung@gmail.com (H.K. Jung), ccrane

  14. STIFFNESS MAPPING OF PLANAR COMPLIANT PARALLEL MECHANISMS IN A

    E-print Network

    Florida, University of

    , Carl D. Crane III University of Florida Department of Mechanical and Aerospace Engineering hyunkwon.jungSTIFFNESS MAPPING OF PLANAR COMPLIANT PARALLEL MECHANISMS IN A SERIAL ARRANGEMENT Hyun K. Jung

  15. Operator-Based Preconditioning of Stiff Hyperbolic Systems

    SciTech Connect

    Reynolds, Daniel R.; Samtaney, Ravi; Woodward, Carol S.

    2009-02-09

    We introduce an operator-based scheme for preconditioning stiff components encoun- tered in implicit methods for hyperbolic systems of partial differential equations posed on regular grids. The method is based on a directional splitting of the implicit operator, followed by a char- acteristic decomposition of the resulting directional parts. This approach allows for solution to any number of characteristic components, from the entire system to only the fastest, stiffness-inducing waves. We apply the preconditioning method to stiff hyperbolic systems arising in magnetohydro- dynamics and gas dynamics. We then present numerical results showing that this preconditioning scheme works well on problems where the underlying stiffness results from the interaction of fast transient waves with slowly-evolving dynamics, scales well to large problem sizes and numbers of processors, and allows for additional customization based on the specific problems under study.

  16. Wing/store flutter with nonlinear pylon stiffness

    NASA Technical Reports Server (NTRS)

    Desmarais, R. N.; Reed, W. H., III

    1980-01-01

    Recent wind tunnel tests and analytical studies show that a store mounted on a pylon with soft pitch stiffness provides substantial increase in flutter speed of fighter aircraft and reduces dependency of flutter on mass and inertia of the store. This concept, termed the decoupler pylon, utilizes a low frequency control system to maintain pitch alignment of the store during maneuvers and changing flight conditions. Under rapidly changing transient loads, however, the alignment control system may allow the store to momentarily bottom against a relatively stiff backup structure in which case the pylon stiffness acts as a hardening nonlinear spring. Such structural nonlinearities are known to affect not only the flutter speed but also the basic behavior of the instability. The influence of pylon stiffness nonlinearities or the flutter characteristics of wing mounted external stores is examined.

  17. Knee joint stiffness and function following total knee arthroplasty 

    E-print Network

    Lane, Judith

    2010-01-01

    Introduction: Studies show that Total Knee Arthroplasty (TKA) is successful for the majority of patients however some continue to experience some functional limitations and anecdotal evidence indicates that stiffness is ...

  18. Arterial Stiffness and Renal Replacement Therapy: A Controversial Topic

    PubMed Central

    Fischer, Edmundo Cabrera; Zócalo, Yanina; Galli, Cintia; Bia, Daniel

    2015-01-01

    The increase of arterial stiffness has been to have a significant impact on predicting mortality in end-stage renal disease patients. Pulse wave velocity (PWV) is a noninvasive, reliable parameter of regional arterial stiffness that integrates the vascular geometry and arterial wall intrinsic elasticity and is capable of predicting cardiovascular mortality in this patient population. Nevertheless, reports on PWV in dialyzed patients are contradictory and sometimes inconsistent: some reports claim the arterial wall stiffness increases (i.e., PWV increase), others claim that it is reduced, and some even state that it augments in the aorta while it simultaneously decreases in the brachial artery pathway. The purpose of this study was to analyze the literature in which longitudinal or transversal studies were performed in hemodialysis and/or peritoneal dialysis patients, in order to characterize arterial stiffness and the responsiveness to renal replacement therapy. PMID:26064684

  19. Gear mesh stiffness and load sharing in planetary gearing

    NASA Technical Reports Server (NTRS)

    Kasuba, R.; August, R.

    1984-01-01

    An interactive computerized analysis was developed for determining load sharing among planetary gears. The load sharing is established as a function of transmitted torque, degree of sun gear fixity, component flexibility, gear tooth quality, and phasing of individual planet gears. A nonlinear variable gear tooth mesh stiffness model was used to simulate the sun/plant and planet/ring gear meshes. The determined load sharing and gear mesh stiffness parameters then can be used for the subsequent assessment of dynamic load factors.

  20. Study of flexural stiffness in delaminated composite plates

    NASA Astrophysics Data System (ADS)

    Kwon, Y. W.; Weiseman, K.

    This paper studied the effect of delamination on the flexural stiffness of laminated composite plates using the FEM. A plate bending element, which has displacements as degrees of freedom at nodes but not rotations, was used. The plate bending element includes the transverse shear deformation. Both angle-ply (+/- theta deg) and cross-ply (0/90 deg) laminates were considered with delamination between the two layers. The reduction in flexural stiffness was calculated by comparing deflections.

  1. Rotator cuff lesions with shoulder stiffness: updated pathomechanisms and management.

    PubMed

    Ko, Jih-Yang; Wang, Feng-Sheng

    2011-01-01

    Few previous studies have investigated the pathomechanism and managements of rotator cuff lesions with shoulder stiffness. Based on observations by Codman in 1934, frozen shoulder presumably relates to rotator cuff tendenitis. In the past six decades, tended to discriminate primary frozen shoulder from secondary shoulder stiffness due to shoulder disorders such as rotator cuff lesions or trauma. Intrinsic degeneration and outlet acromial spur impingement are reported as pathogenic causes of rotator cuff lesion. Although patients with rotator cuff lesions with shoulder stiffness or adhesive capsulitis (frozen shoulder) may have similar complaints about pain and motion limitation, the pathological reactions in these disorders remain unclear. In our investigation of clinical vignettes of shoulder stiffness, inflammation-mediated adhesions in the subacromial bursa in rotator cuff lesions, and changes in inflammatory cytokine levels have been linked to myofibroblast recruitment in the subacromial bursa. Our study provides the first indication that increased interleukin -1? expression and myofibroblast recruitment in the subacromial bursa are correlated with rotator cuff lesions with shoulder stiffness. Increased inflammatory cytokine concentrations in the lesions also provide new molecular insight into the pathological role of the subacromial bursa in the development of shoulder stiffness in rotator cuff lesions. Although rotator cuff repair is a shoulder-tightening procedure and is not recommended until resolution of the shoulder stiffness in rotator cuff lesions with stiff shoulder, our clinical evidence-based survey suggests that a combined procedure of manipulation, lysis of adhesions, acromioplasty, and rotator cuff repair is a useful procedure if the symptoms do not improve 3 months of aggressive rehabilitation. PMID:21880187

  2. Effects of age and diabetes on scleral stiffness.

    PubMed

    Coudrillier, Baptiste; Pijanka, Jacek; Jefferys, Joan; Sorensen, Thomas; Quigley, Harry A; Boote, Craig; Nguyen, Thao D

    2015-07-01

    The effects of diabetes on the collagen structure and material properties of the sclera are unknown but may be important to elucidate whether diabetes is a risk factor for major ocular diseases such as glaucoma. This study provides a quantitative assessment of the changes in scleral stiffness and collagen fiber alignment associated with diabetes. Posterior scleral shells from five diabetic donors and seven non-diabetic donors were pressurized to 30?mm Hg. Three-dimensional surface displacements were calculated during inflation testing using digital image correlation (DIC). After testing, each specimen was subjected to wide-angle X-ray scattering (WAXS) measurements of its collagen organization. Specimen-specific finite element models of the posterior scleras were generated from the experimentally measured geometry. An inverse finite element analysis was developed to determine the material properties of the specimens, i.e., matrix and fiber stiffness, by matching DIC-measured and finite element predicted displacement fields. Effects of age and diabetes on the degree of fiber alignment, matrix and collagen fiber stiffness, and mechanical anisotropy were estimated using mixed effects models accounting for spatial autocorrelation. Older age was associated with a lower degree of fiber alignment and larger matrix stiffness for both diabetic and non-diabetic scleras. However, the age-related increase in matrix stiffness was 87% larger in diabetic specimens compared to non-diabetic controls and diabetic scleras had a significantly larger matrix stiffness (p?=?0.01). Older age was associated with a nearly significant increase in collagen fiber stiffness for diabetic specimens only (p?=?0.06), as well as a decrease in mechanical anisotropy for non-diabetic scleras only (p?=?0.04). The interaction between age and diabetes was not significant for all outcomes. This study suggests that the age-related increase in scleral stiffness is accelerated in eyes with diabetes, which may have important implications in glaucoma. PMID:25751456

  3. On the determination of the coefficients of the Gaussian general theory of the Earth's magnetism for the year 1885 and about the relationship of the three Earth-magnetic elements

    NASA Technical Reports Server (NTRS)

    Fritsche, H.

    1983-01-01

    An attempt is made to judge the value of the Gaussian series for the Earth's magnetism. The computation employed to do this uses the method of the least and greatest coefficients. The number of unknown which had to be calculated from the individual groups was at most only four. All symbols of Gauss were retained.

  4. A Multiwell Platform for Studying Stiffness-Dependent Cell Biology

    PubMed Central

    Mih, Justin D.; Sharif, Asma S.; Liu, Fei; Marinkovic, Aleksandar; Symer, Matthew M.; Tschumperlin, Daniel J.

    2011-01-01

    Adherent cells are typically cultured on rigid substrates that are orders of magnitude stiffer than their tissue of origin. Here, we describe a method to rapidly fabricate 96 and 384 well platforms for routine screening of cells in tissue-relevant stiffness contexts. Briefly, polyacrylamide (PA) hydrogels are cast in glass-bottom plates, functionalized with collagen, and sterilized for cell culture. The Young's modulus of each substrate can be specified from 0.3 to 55 kPa, with collagen surface density held constant over the stiffness range. Using automated fluorescence microscopy, we captured the morphological variations of 7 cell types cultured across a physiological range of stiffness within a 384 well plate. We performed assays of cell number, proliferation, and apoptosis in 96 wells and resolved distinct profiles of cell growth as a function of stiffness among primary and immortalized cell lines. We found that the stiffness-dependent growth of normal human lung fibroblasts is largely invariant with collagen density, and that differences in their accumulation are amplified by increasing serum concentration. Further, we performed a screen of 18 bioactive small molecules and identified compounds with enhanced or reduced effects on soft versus rigid substrates, including blebbistatin, which abolished the suppression of lung fibroblast growth at 1 kPa. The ability to deploy PA gels in multiwell plates for high throughput analysis of cells in tissue-relevant environments opens new opportunities for the discovery of cellular responses that operate in specific stiffness regimes. PMID:21637769

  5. Mesenchymal Stem Cell Durotaxis Depends on Substrate Stiffness Gradient Strength

    PubMed Central

    Vincent, Ludovic G.; Choi, Yu Suk; Alonso-Latorre, Baldomero; del Álamo, Juan C.; Engler, Adam J.

    2013-01-01

    Mesenchymal stem cells (MSCs) respond to niche elasticity, which varies between and within tissues. Stiffness gradients result from pathological conditions but also occur through normal variation, e.g. muscle. MSCs undergo directed migration even in response to shallow stiffness gradients before differentiating. More refined gradients of both stiffness range and strength are needed to better understand mechanical regulation of migration in normal and disease pathologies. We describe polyacrylamide stiffness gradient fabrication using three distinct systems that generate stiffness gradients of physiological (1 Pa/µm), pathological (10 Pa/µm), and step (? 100Pa/um) strength spanning physiologically relevant stiffness for most soft tissue, i.e. 1–12 kPa. MSCs migrated to the stiffest region for each gradient. Time-lapse microscopy revealed that migration velocity scaled directly with gradient strength. Directed migration was reduced in the presence of the contractile agonist lysophosphatidic acid (LPA) and cytoskeletal-perturbing drugs nocodazole and cytochalasin; LPA- and nocodazole-treated cells remained spread and protrusive, while cytochalasin-treated cells did not. Untreated and nocodazole-treated cells spread in a similar manner, but nocodazole-treated cells had greatly diminished traction forces. These data suggest that actin is required for migration whereas microtubules are required for directed migration. The data also imply that in vivo, MSCs may have a more significant contribution to repairs in stiffer regions where they may preferentially accumulate. PMID:23390141

  6. Therapeutic modification of arterial stiffness: An update and comprehensive review

    PubMed Central

    Wu, Ching-Fen; Liu, Pang-Yen; Wu, Tsung-Jui; Hung, Yuan; Yang, Shih-Ping; Lin, Gen-Min

    2015-01-01

    Arterial stiffness has been recognized as a marker of cardiovascular disease and associated with long-term worse clinical outcomes in several populations. Age, hypertension, smoking, and dyslipidemia, known as traditional vascular risk factors, as well as diabetes, obesity, and systemic inflammation lead to both atherosclerosis and arterial stiffness. Targeting multiple modifiable risk factors has become the main therapeutic strategy to improve arterial stiffness in patients at high cardiovascular risk. Additionally to life style modifications, long-term ?-3 fatty acids (fish oil) supplementation in diet may improve arterial stiffness in the population with hypertension or metabolic syndrome. Pharmacological treatment such as renin-angiotensin-aldosterone system antagonists, metformin, and 3-hydroxy-3-methyl-glutaryl-CoA reductase inhibitors were useful in individuals with hypertension and diabetes. In obese population with obstructive sleep apnea, weight reduction, aerobic exercise, and continuous positive airway pressure treatment may also improve arterial stiffness. In the populations with chronic inflammatory disease such as rheumatoid arthritis, a use of antibodies against tumor necrosis factor-alpha could work effectively. Other therapeutic options such as renal sympathetic nerve denervation for patients with resistant hypertension are investigated in many ongoing clinical trials. Therefore our comprehensive review provides knowledge in detail regarding many aspects of pathogenesis, measurement, and management of arterial stiffness in several populations, which would be helpful for physicians to make clinical decision. PMID:26635922

  7. Electron temperature critical gradient and transport stiffness in DIII-D

    NASA Astrophysics Data System (ADS)

    Smith, S. P.; Petty, C. C.; White, A. E.; Holland, C.; Bravenec, R.; Austin, M. E.; Zeng, L.; Meneghini, O.

    2015-08-01

    In a continuing effort to validate turbulent transport models, the electron energy flux has been probed as a function of electron temperature gradient on the DIII-D tokamak. In the scan of gradient, a critical electron temperature gradient has been found in the electron heat fluxes and stiffness at various radii in L-mode plasmas. The TGLF reduced turbulent transport model (Staebler et al 2007 Phys. Plasmas 14 055909) and full gyrokinetic GYRO model (Candy and Waltz 2003 J. Comput. Phys. 186 545) recover the general trend of increasing electron energy flux with increasing electron temperature gradient scale length, but they do not predict the absolute level of transport at all radii and gradients. Comparing the experimental observations of incremental (heat pulse) diffusivity and stiffness to the models’ reveals that TGLF reproduces the trends in increasing diffusivity and stiffness with increasing electron temperature gradient scale length with a critical gradient behavior. The critical gradient of TGLF is found to have a dependence on q95, contrary to the independence of the experimental critical gradient from q95.

  8. Explicit Integration of Extremely Stiff Reaction Networks: Quasi-Steady-State Methods

    SciTech Connect

    Guidry, Mike W; Harris, James A

    2013-01-01

    A preceding paper [1] demonstrated that explicit asymptotic methods generally work much better for extremely stiff reaction networks than has previously been shown in the literature. There we showed that for systems well removed from equilibrium explicit asymptotic methods can rival standard implicit codes in speed and accuracy for solving extremely stiff differential equations. In this paper we continue the investigation of systems well removed from equilibrium by examining quasi-steady-state (QSS) methods as an alternative to asymptotic methods. We show that for systems well removed from equilibrium, QSS methods also can compete with, or even exceed, standard implicit methods, even for extremely stiff networks, and in many cases give somewhat better integration speed than for asymptotic methods. As for asymptotic methods, we will find that QSS methods give correct results, but with non-competitive integration speed as equilibrium is approached. Thus, we shall find that both asymptotic and QSS methods must be supplemented with partial equilibrium methods as equilibrium is approached to remain competitive with implicit methods.

  9. The equilibrium state method for hyperbolic conservation laws with stiff reaction terms

    NASA Astrophysics Data System (ADS)

    Zhang, Bin; Liu, Hong; Chen, Fang; Wang, Jian Hang

    2014-04-01

    A new fractional-step method is proposed for numerical simulations of hyperbolic conservation laws with stiff source terms arising from chemically reactive flows. In stiff reaction problems, a well-known spurious numerical phenomenon, the incorrect propagation speed of discontinuities, may occur in general fractional-step algorithm due to the underresolved numerical solution in both space and time. The basic idea of the present proposed scheme is to replace the cell average representation with a two-equilibrium states reconstruction during the reaction step, which allows us to obtain the correct propagation of discontinuities for stiff reaction problems in an underresolved mesh. Because the definition of these two-equilibrium states for each transition cell is independent of its neighboring cells, the proposed method can be extended to multi-dimensional problems directly. In addition, this method is promising to deal with more complicated real-world problems after being extended to multi-species/multi-reactions system. Extensive numerical examples for one- and two-dimensional scalar and Euler system demonstrate the reliability and robustness of this novel method.

  10. Stiffness threshold of randomly distributed carbon nanotube networks

    NASA Astrophysics Data System (ADS)

    Chen, Yuli; Pan, Fei; Guo, Zaoyang; Liu, Bin; Zhang, Jianyu

    2015-11-01

    For carbon nanotube (CNT) networks, with increasing network density, there may be sudden changes in the properties, such as the sudden change in electrical conductivity at the electrical percolation threshold. In this paper, the change in stiffness of the CNT networks is studied and especially the existence of stiffness threshold is revealed. Two critical network densities are found to divide the stiffness behavior into three stages: zero stiffness, bending dominated and stretching dominated stages. The first critical network density is a criterion to judge whether or not the network is capable of carrying load, defined as the stiffness threshold. The second critical network density is a criterion to measure whether or not most of the CNTs in network are utilized effectively to carry load, defined as bending-stretching transitional threshold. Based on the geometric probability analysis, a theoretical methodology is set up to predict the two thresholds and explain their underlying mechanisms. The stiffness threshold is revealed to be determined by the statical determinacy of CNTs in the network, and can be estimated quantitatively by the stabilization fraction of network, a newly proposed parameter in this paper. The other threshold, bending-stretching transitional threshold, which signs the conversion of dominant deformation mode, is verified to be well evaluated by the proposed defect fraction of network. According to the theoretical analysis as well as the numerical simulation, the average intersection number on each CNT is revealed as the only dominant factor for the electrical percolation and the stiffness thresholds, it is approximately 3.7 for electrical percolation threshold, and 5.2 for the stiffness threshold of 2D networks. For 3D networks, they are 1.4 and 4.4. And it also affects the bending-stretching transitional threshold, together with the CNT aspect ratio. The average intersection number divided by the fourth root of CNT aspect ratio is found to be an invariant at the bending-stretching transitional threshold, which is 6.7 and 6.3 for 2D and 3D networks, respectively. Based on this study, a simple piecewise expression is summarized to describe the relative stiffness of CNT networks, in which the relative stiffness of networks depends on the relative network density as well as the CNT aspect ratio. This formula provides a solid theoretical foundation for the design optimization and property prediction of CNT networks.

  11. Hydration Status Is Associated with Aortic Stiffness, but Not with Peripheral Arterial Stiffness, in Chronically Hemodialysed Patients

    PubMed Central

    Bia, Daniel; Galli, Cintia; Valtuille, Rodolfo; Zócalo, Yanina; Wray, Sandra A.; Armentano, Ricardo L.; Cabrera Fischer, Edmundo I.

    2015-01-01

    Background. Adequate fluid management could be essential to minimize high arterial stiffness observed in chronically hemodialyzed patients (CHP). Aim. To determine the association between body fluid status and central and peripheral arterial stiffness levels. Methods. Arterial stiffness was assessed in 65 CHP by measuring the pulse wave velocity (PWV) in a central arterial pathway (carotid-femoral) and in a peripheral pathway (carotid-brachial). A blood pressure-independent regional arterial stiffness index was calculated using PWV. Volume status was assessed by whole-body multiple-frequency bioimpedance. Patients were first observed as an entire group and then divided into three different fluid status-related groups: normal, overhydration, and dehydration groups. Results. Only carotid-femoral stiffness was positively associated (P < 0.05) with the hydration status evaluated through extracellular/intracellular fluid, extracellular/Total Body Fluid, and absolute and relative overhydration. Conclusion. Volume status and overload are associated with central, but not peripheral, arterial stiffness levels with independence of the blood pressure level, in CHP. PMID:26167301

  12. BIOMECHANICS OF DOLPHIN HEARING: A COMPARISON OF MIDDLE AND INNER EAR STIFFNESS WITH OTHER MAMMALIAN

    E-print Network

    BIOMECHANICS OF DOLPHIN HEARING: A COMPARISON OF MIDDLE AND INNER EAR STIFFNESS WITH OTHER was to measure both middle ear stiffness and basilar membrane stiffness for the bottlenose dolphin (Tursiops that the point stiffness of the bottlenose dolphin basilar membrane has a gradient from 20 N/m near the base to 1

  13. A piezoelectric-based infinite stiffness generation method for strain-type load sensors

    NASA Astrophysics Data System (ADS)

    Zhang, Shuwen; Shao, Shubao; Chen, Jie; Xu, Minglong

    2015-11-01

    Under certain application conditions like nanoindentation technology and the mechanical property measurement of soft materials, the elastic deformation of strain-type load sensors affects their displacement measurement accuracy. In this work, a piezoelectric-based infinite stiffness generation method for strain-type load sensors that compensates for this elastic deformation is presented. The piezoelectric material-based deformation compensation method is proposed. An Hottinger Baldwin Messtechnik GmbH (HBM) Z30A/50N load sensor acts as the foundation of the method presented in this work. The piezoelectric stack is selected based on its size, maximum deformation value, blocking force and stiffness. Then, a clamping and fixing structure is designed to integrate the HBM sensor with the piezoelectric stack. The clamping and fixing structure, piezoelectric stack and HBM load sensor comprise the sensing part of the enhanced load sensor. The load-deformation curve and the voltage-deformation curve of the enhanced load sensor are then investigated experimentally. Because a hysteresis effect exists in the piezoelectric structure, the relationship between the control signal and the deformation value of the piezoelectric material is nonlinear. The hysteresis characteristic in a quasi-static condition is studied and fitted using a quadratic polynomial, and its coefficients are analyzed to enable control signal prediction. Applied arithmetic based on current theory and the fitted data is developed to predict the control signal. Finally, the experimental effects of the proposed method are presented. It is shown that when a quasi-static load is exerted on this enhanced strain-type load sensor, the deformation is reduced and the equivalent stiffness appears to be almost infinite.

  14. Evaluation of fatigue life of CRM-reinforced SMA and its relationship to dynamic stiffness.

    PubMed

    Mashaan, Nuha Salim; Karim, Mohamed Rehan; Abdel Aziz, Mahrez; Ibrahim, Mohd Rasdan; Katman, Herda Yati; Koting, Suhana

    2014-01-01

    Fatigue cracking is an essential problem of asphalt concrete that contributes to pavement damage. Although stone matrix asphalt (SMA) has significantly provided resistance to rutting failure, its resistance to fatigue failure is yet to be fully addressed. The aim of this study is to evaluate the effect of crumb rubber modifier (CRM) on stiffness and fatigue properties of SMA mixtures at optimum binder content, using four different modification levels, namely, 6%, 8%, 10%, and 12% CRM by weight of the bitumen. The testing undertaken on the asphalt mix comprises the dynamic stiffness (indirect tensile test), dynamic creep (repeated load creep), and fatigue test (indirect tensile fatigue test) at temperature of 25°C. The indirect tensile fatigue test was conducted at three different stress levels (200, 300, and 400 kPa). Experimental results indicate that CRM-reinforced SMA mixtures exhibit significantly higher fatigue life compared to the mixtures without CRM. Further, higher correlation coefficient was obtained between the fatigue life and resilient modulus as compared to permanent strain; thus resilient modulus might be a more reliable indicator in evaluating the fatigue life of asphalt mixture. PMID:25050406

  15. Evaluation of Fatigue Life of CRM-Reinforced SMA and Its Relationship to Dynamic Stiffness

    PubMed Central

    Mashaan, Nuha Salim; Karim, Mohamed Rehan; Abdel Aziz, Mahrez; Ibrahim, Mohd Rasdan; Katman, Herda Yati

    2014-01-01

    Fatigue cracking is an essential problem of asphalt concrete that contributes to pavement damage. Although stone matrix asphalt (SMA) has significantly provided resistance to rutting failure, its resistance to fatigue failure is yet to be fully addressed. The aim of this study is to evaluate the effect of crumb rubber modifier (CRM) on stiffness and fatigue properties of SMA mixtures at optimum binder content, using four different modification levels, namely, 6%, 8%, 10%, and 12% CRM by weight of the bitumen. The testing undertaken on the asphalt mix comprises the dynamic stiffness (indirect tensile test), dynamic creep (repeated load creep), and fatigue test (indirect tensile fatigue test) at temperature of 25°C. The indirect tensile fatigue test was conducted at three different stress levels (200, 300, and 400?kPa). Experimental results indicate that CRM-reinforced SMA mixtures exhibit significantly higher fatigue life compared to the mixtures without CRM. Further, higher correlation coefficient was obtained between the fatigue life and resilient modulus as compared to permanent strain; thus resilient modulus might be a more reliable indicator in evaluating the fatigue life of asphalt mixture. PMID:25050406

  16. Semi-active damping with negative stiffness for multi-mode cable vibration mitigation: approximate collocated control solution

    NASA Astrophysics Data System (ADS)

    Weber, F.; Distl, H.

    2015-11-01

    This paper derives an approximate collocated control solution for the mitigation of multi-mode cable vibration by semi-active damping with negative stiffness based on the control force characteristics of clipped linear quadratic regulator (LQR). The control parameters are derived from optimal modal viscous damping and corrected in order to guarantee that both the equivalent viscous damping coefficient and the equivalent stiffness coefficient of the semi-active cable damper force are equal to their desired counterparts. The collocated control solution with corrected control parameters is numerically validated by free decay tests of the first four cable modes and combinations of these modes. The results of the single-harmonic tests demonstrate that the novel approach yields 1.86 times more cable damping than optimal modal viscous damping and 1.87 to 2.33 times more damping compared to a passive oil damper whose viscous damper coefficient is optimally tuned to the targeted mode range of the first four modes. The improvement in case of the multi-harmonic vibration tests, i.e. when modes 1 and 3 and modes 2 and 4 are vibrating at the same time, is between 1.55 and 3.81. The results also show that these improvements are obtained almost independent of the cable anti-node amplitude. Thus, the proposed approximate real-time applicable collocated semi-active control solution which can be realized by magnetorheological dampers represents a promising tool for the efficient mitigation of stay cable vibrations.

  17. Analysis and design of variable stiffness composite cylinders

    NASA Astrophysics Data System (ADS)

    Tatting, Brian Frederick

    An investigation of the possible performance improvements of thin circular cylindrical shells through the use of the variable stiffness concept is presented. The variable stiffness concept implies that the stiffness parameters change spatially throughout the structure. This situation is achieved mainly through the use of curvilinear fibers within a fiber-reinforced composite laminate. The governing static equilibrium equations include sufficient detail to correctly model several types of nonlinearity, including the formation of a nonlinear shell boundary layer as well as the Brazier effect due to nonlinear bending of long cylinders. Four distinct cases of loading and stiffness variation are chosen to investigate. The initial investigation deals cylindrical shells in which all quantities are constant around the circumference of the cylinder. This axisymmetric case includes a stiffness variation exclusively in the axial direction, and the only pertinent loading scenarios include constant loads of axial compression, pressure, and torsion. The results for these cases indicate that little improvement over traditional laminates exists through the use of curvilinear fibers. The second problem involves arbitrary loading of a cylinder with a stiffness variation only in the circumferential direction. The problem takes the form of an analysis of a cross-section for a short cylinder segment. It is found that the most significant improvements in load-carrying capability exist for loads that also vary around the circumference of the shell, namely bending and shear forces. The stiffness variation of the optimal designs contribute to the increased performance in two ways: lowering the stresses in the critical areas through redistribution; and providing a relatively stiff region that alters the buckling behavior of the structure. These results led to an in-depth optimization study involving weight optimization of a fuselage structure subjected to typical design constraints. It is found that standard variable stiffness designs a offer the added advantage of tailorability of distinct regions of the structure that experience drastically different loading conditions. The last two problems work involve the nonlinear phenomenon of long tubes under bending. The dominating influence for long cylinders under bending is the ovalization of the cross-section. Possible improvement of the critical buckling moments for these structures is investigated using either a circumferential or axial stiffness variation. For the circumferential case involving infinite length cylinders, slight improvements can be observed by designing structures that resist the cross-sectional deformation yet do not detract from the buckling resistance at the critical location. The results also indicate that buckling behavior is extremely dependent on cylinder length. For finite length cylinders contain an axial stiffness variation, the only mechanism that exhibits improved response are those that effectively shorten the length of the cylinder. The use of curvilinear fibers was not able to achieve this effect in sufficient degree to resist the deformation, but ring stiffeners produced the desired response. Thus the variable stiffness concept is most effective at improving the bending response of long cylinders through the use of a circumferential stiffness variation. (Abstract shortened by UMI.)

  18. Transport coefficients of soft repulsive particle fluids

    NASA Astrophysics Data System (ADS)

    Heyes, D. M.; Bra?ka, A. C.

    2008-03-01

    Molecular dynamics computer simulation has been used to compute the self-diffusion coefficient, D, and shear viscosity, ?s, of soft-sphere fluids, in which the particles interact through the soft-sphere pair potential, phi(r) = epsilon(?/r)n, where n measures the steepness or stiffness of the potential, epsilon and ? are a characteristic energy and distance, respectively. The simulations were carried out on monodisperse systems for a range of n values from the hard-sphere (n\\to \\infty ) limit down to n = 4 over a range of densities. An ideal glass transition value was estimated from the limit where D and \\eta_{\\mathrm {s}}^{-1}\\to 0 for each value of n. Nucleation of the crystalline phase was found to intervene prior to the formation of the glass itself, as has been found previously for hard spheres (i.e. n\\to \\infty ). With increasing softness the glass transition moves further within the solid part of the phase diagram, as predicted by Cardenas and Tosi (2005 Phys. Lett. A 336 423), although the volume fractions at the glass transition estimated by the current procedure here are systematically lower than the predictions of that study.

  19. Arterial Stiffness, Kidney Function, and Chronic Kidney Disease Progression

    PubMed Central

    Townsend, Raymond R.; Tomiyama, Hirofumi

    2013-01-01

    Arterial stiffness can nowadays be measured easily and noninvasively around the globe. Although well established as an independent predictor of cardiovascular events, less is known about the role of arterial stiffness in the progressive loss of kidney function once chronic kidney disease (CKD) is established. In addition to measures of arterial stiffness, a number of devices now noninvasively record the pulse profile from sites such as the radial artery and, using internal algorithms, are able to estimate central pressure profiles. Although these devices have generated much data on the prediction of cardiovascular events, e.g. measures of arterial stiffness, there is much less known about the predictive utility of these measures in CKD progression. In this review, we cover approaches to arterial stiffness as measured by pulse wave velocity and discuss measures of the systolic and diastolic contour of the pulse waveform vis-à-vis their relationship to declines in kidney function over time. We restrict our coverage to studies that have longitudinal data, but we also include a table of studies, which, to our knowledge, have only published cross-sectional data at this time.

  20. Variable stiffness material and structural concepts for morphing applications

    NASA Astrophysics Data System (ADS)

    Kuder, Izabela K.; Arrieta, Andres F.; Raither, Wolfram E.; Ermanni, Paolo

    2013-11-01

    Morphing, understood as the ability to undergo pronounced shape adaptations to optimally respond to a diversity of operational conditions, has been singled out as a future direction in the pursuit of maximised efficiency of lightweight structures. Whereas a certain degree of adaptivity can be accomplished conventionally by means of mechanical systems, compliance allowing for substantial reversible deformability exhibits far more potential as a morphing strategy. A promising solution to the inherent contradiction between high stiffness and reversible deformation capacity posed by morphing is offered by introducing variable stiffness components. This notion indicates the provision of a controllable range of deformation resistance levels in place of fixed properties, as required by real-time shape adaptation dictated by maximum efficiency under changing external conditions. With special emphasis on the morphing context, the current review aims to identify the main tendencies, undertaking a systematic classification of existing approaches involving stiffness variability. Four broad categories in which variable stiffness has been applied to morphing are therefore distinguished and detailed: material engineering, active mechanical design, semi-active techniques and elastic structural behaviour. Adopting a wide perspective, the study highlights key capabilities, limitations and challenges. The need for attention directed to the variable stiffness strategy is recognised and the significance of intensive research activities in a highly integrated and multidisciplinary environment emphasised if higher maturity stages of the concepts are to be reached. Finally, the potential of emerging directions of semi-active design involving electro-bonded laminates and multi-stable structures is brought into focus.

  1. Pharmacological bronchodilation is partially mediated by reduced airway wall stiffness

    PubMed Central

    Ansell, T K; Noble, P B; Mitchell, H W; McFawn, P K

    2014-01-01

    Background and Purpose In asthmatic patients, airflow limitation is at least partly reversed by administration of pharmacological bronchodilators, typically ?2-adrenoceptor agonists. In addition to receptor-mediated bronchodilation, the dynamic mechanical environment of the lung itself can reverse bronchoconstriction. We have now explored the possibility that bronchodilators exert a synergistic effect with oscillatory loads by virtue of reducing airway wall stiffness, and therefore, enhancing the bronchodilatory response to breathing manoeuvres. Experimental Approach Whole porcine bronchial segments in vitro were contracted to carbachol and relaxed to the non-specific ?-adrenoceptor agonist, isoprenaline, under static conditions or during simulated breathing manoeuvres. Key Results The bronchodilatory response to isoprenaline was greater during breathing manoeuvres compared with the response under static conditions. As the bronchodilatory response to breathing manoeuvres is dependent upon airway smooth muscle (ASM) strain, and therefore, airway wall stiffness, our findings are likely to be explained by the effect of isoprenaline on reducing airway wall stiffness, which increased ASM strain, producing greater bronchodilation. Conclusions and Implications A contribution of reduced airway stiffness and increased ASM strain to the bronchodilator action of isoprenaline is shown, suggesting that oscillatory loads act synergistically with pharmacologically mediated bronchodilation. The implications for the treatment of asthma are that reducing airway wall stiffness represents a potential target for novel pharmacological agents. PMID:24846164

  2. Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound

    PubMed Central

    Kuo, Maggie M.; Barodka, Viachaslau; Abraham, Theodore P.; Steppan, Jochen; Shoukas, Artin A.; Butlin, Mark; Avolio, Alberto; Berkowitz, Dan E.; Santhanam, Lakshmi

    2014-01-01

    We present a protocol for measuring in vivo aortic stiffness in mice using high-resolution ultrasound imaging. Aortic diameter is measured by ultrasound and aortic blood pressure is measured invasively with a solid-state pressure catheter. Blood pressure is raised then lowered incrementally by intravenous infusion of vasoactive drugs phenylephrine and sodium nitroprusside. Aortic diameter is measured for each pressure step to characterize the pressure-diameter relationship of the ascending aorta. Stiffness indices derived from the pressure-diameter relationship can be calculated from the data collected. Calculation of arterial compliance is described in this protocol. This technique can be used to investigate mechanisms underlying increased aortic stiffness associated with cardiovascular disease and aging. The technique produces a physiologically relevant measure of stiffness compared to ex vivo approaches because physiological influences on aortic stiffness are incorporated in the measurement. The primary limitation of this technique is the measurement error introduced from the movement of the aorta during the cardiac cycle. This motion can be compensated by adjusting the location of the probe with the aortic movement as well as making multiple measurements of the aortic pressure-diameter relationship and expanding the experimental group size. PMID:25489936

  3. LSENS, a general chemical kinetics and sensitivity analysis code for gas-phase reactions: User's guide

    NASA Technical Reports Server (NTRS)

    Radhakrishnan, Krishnan; Bittker, David A.

    1993-01-01

    A general chemical kinetics and sensitivity analysis code for complex, homogeneous, gas-phase reactions is described. The main features of the code, LSENS, are its flexibility, efficiency and convenience in treating many different chemical reaction models. The models include static system, steady, one-dimensional, inviscid flow, shock initiated reaction, and a perfectly stirred reactor. In addition, equilibrium computations can be performed for several assigned states. An implicit numerical integration method, which works efficiently for the extremes of very fast and very slow reaction, is used for solving the 'stiff' differential equation systems that arise in chemical kinetics. For static reactions, sensitivity coefficients of all dependent variables and their temporal derivatives with respect to the initial values of dependent variables and/or the rate coefficient parameters can be computed. This paper presents descriptions of the code and its usage, and includes several illustrative example problems.

  4. Comparative Analysis of the Flexural Stiffness of Pinniped Vibrissae

    PubMed Central

    Ginter Summarell, Carly C.; Ingole, Sudeep; Fish, Frank E.; Marshall, Christopher D.

    2015-01-01

    Vibrissae are important components of the mammalian tactile sensory system and are used to detect vibrotactile stimuli in the environment. Pinnipeds have the largest and most highly innervated vibrissae among mammals, and the hair shafts function as a biomechanical filter spanning the environmental stimuli and the neural mechanoreceptors deep in the follicle-sinus complex. Therefore, the material properties of these structures are critical in transferring vibrotactile information to the peripheral nervous system. Vibrissae were tested as cantilever beams and their flexural stiffness (EI) was measured to test the hypotheses that the shape of beaded vibrissae reduces EI and that vibrissae are anisotropic. EI was measured at two locations on each vibrissa, 25% and 50% of the overall length, and at two orientations to the point force. EI differed in orientations that were normal to each other, indicating a functional anisotropy. Since vibrissae taper from base to tip, the second moment of area (I) was lower at 50% than 25% of total length. The anterior orientation exhibited greater EI values at both locations compared to the dorsal orientation for all species. Smooth vibrissae were generally stiffer than beaded vibrissae. The profiles of beaded vibrissae are known to decrease the amplitude of vibrations when protruded into a flow field. The lower EI values of beaded vibrissae, along with the reduced vibrations, may function to enhance the sensitivity of mechanoreceptors to detection of small changes in flow from swimming prey by increasing the signal to noise ratio. This study builds upon previous morphological and hydrodynamic analyses of vibrissae and is the first comparative study of the mechanical properties of pinniped vibrissae. PMID:26132102

  5. Time-varying torsional stiffness identification on a vertical beam using Chebyshev polynomials

    NASA Astrophysics Data System (ADS)

    Martel, François; Rancourt, Denis; Chochol, Catherine; St-Amant, Yves; Chesne, Simon; Rémond, Didier

    2015-03-01

    This paper investigates the performance of the Chebyshev polynomial basis to identify the time-varying mechanical impedance of a vertical beam in torsion. The projection, derivation and product properties of Chebyshev polynomials were used to linearize the differential equation of 1-DOF mechanical systems having multiple time-varying parameters. This allowed the identification of a reduced set of projection coefficients without prior knowledge of initial system states conditions. The method was then applied to experimental data obtained from an equilateral beam excited in torsion while one beam support location was changed over time. Results showed 6.62×10-2% error in stiffness predictions compared to theoretical estimates. Signal filtering was critical to avoid contamination by bending modes of the beam and prior knowledge of inertia led to better results.

  6. Diffusion coefficients in leaflets of bilayer membranes.

    PubMed

    Seki, Kazuhiko; Mogre, Saurabh; Komura, Shigeyuki

    2014-02-01

    We study diffusion coefficients of liquid domains by explicitly taking into account the two-layered structure called leaflets of the bilayer membrane. In general, the velocity fields associated with each leaflet are different and the layers sliding past each other cause frictional coupling. We obtain analytical results of diffusion coefficients for a circular liquid domain in a leaflet, and quantitatively study their dependence on the interleaflet friction. We also show that the diffusion coefficients diverge in the absence of coupling between the bilayer and solvents, even when the interleaflet friction is taken into account. In order to corroborate our theory, the effect of the interleaflet friction on the correlated diffusion is examined. PMID:25353515

  7. Double-smoothing for Varying Coefficient Models.

    PubMed

    Tang, Wan; Zuo, Guoxin; He, Hua

    2011-12-01

    Moderation analyses are widely used in biomedical and psychosocial research to investigate differential treatment effects, with moderators frequently identified through testing the significance of the interaction between the predictor and the potential moderator under strong parametric assumptions. Without imposing any parametric forms on how the moderators may affect the relationship between predictors and responses, varying coefficient models address this fundamental problem of strong parametric assumptions with current practice of moderation analysis and provide a much broader class of models for complex moderation relationships. Local polynomial, especially local linear, methods are commonly used in estimating the varying coefficient models. Recently, a double-smoothing (DS) local linear method has been proposed for nonparametric regression models, with nice properties compared to local linear and local cubic methods. In this paper, we generalize DS to varying coefficient models, and show that it holds similar advantages over local linear and local cubic methods. PMID:22121327

  8. SLE_k: correlation functions in coefficient problem

    E-print Network

    Loutsenko, Igor

    2012-01-01

    We apply method of correlation functions to coefficient problem in stochastic geometry. In particular, we give a proof for some universal patterns conjectured by M. Zinsmeister \\cite{DNNZ} for second moments of coefficients of conformal mappings for special values of $kappa$ in the whole-plane Schramm-Loewner evolution SLE_kappa). We propose to use multi-point correlation functions for study of higher moments in coefficient problem. Generalizations related to the Levy-type processes are also considered.

  9. Tissue Stiffness Dictates Development, Homeostasis, and Disease Progression

    PubMed Central

    Handorf, Andrew M; Zhou, Yaxian; Halanski, Matthew A; Li, Wan-Ju

    2015-01-01

    Abstract Tissue development is orchestrated by the coordinated activities of both chemical and physical regulators. While much attention has been given to the role that chemical regulators play in driving development, researchers have recently begun to elucidate the important role that the mechanical properties of the extracellular environment play. For instance, the stiffness of the extracellular environment has a role in orienting cell division, maintaining tissue boundaries, directing cell migration, and driving differentiation. In addition, extracellular matrix stiffness is important for maintaining normal tissue homeostasis, and when matrix mechanics become imbalanced, disease progression may ensue. In this article, we will review the important role that matrix stiffness plays in dictating cell behavior during development, tissue homeostasis, and disease progression. PMID:25915734

  10. Effect of surface stress on the stiffness of cantilever plates.

    PubMed

    Lachut, Michael J; Sader, John E

    2007-11-16

    Measurements over the past 30 years have indicated that surface stress can significantly affect the stiffness of microcantilever plates. Several one-dimensional models based on beam theory have been proposed to explain this phenomenon, but are found to be in violation of Newton's third law, in spite of their good agreement with measurements. In this Letter, we review this work and rigorously examine the effect of surface stress on the stiffness of cantilever plates using a full three-dimensional model. This study establishes the relationship between surface stress and cantilever stiffness, and in so doing elucidates its scaling behavior with cantilever dimensions. The use of short nanoscale cantilevers thus presents the most promising avenue for future investigations. PMID:18233163

  11. Design and experiment of a high-static-low-dynamic stiffness isolator using a negative stiffness magnetic spring

    NASA Astrophysics Data System (ADS)

    Zheng, Yisheng; Zhang, Xinong; Luo, Yajun; Yan, Bo; Ma, Chicheng

    2016-01-01

    To improve the vibration isolation performance under low frequency excitation, a negative stiffness magnetic spring (NSMS) is employed to reduce the resonance frequency of the linear isolator. The NSMS comprising a pair of coaxial ring permanent magnets is installed in parallel with the mechanical spring to counteract its positive stiffness. The major feature of the isolator is that it has high static low dynamic stiffness (HSLDS). In this paper, the model of the HSLDS isolator and the NSMS is analyzed firstly; and the magnetic force and stiffness exerted between the inner magnet and the outer magnet is then calculated based on the Amperian current model. After analyzing the effect of the geometric parameters of the magnets on the stiffness characteristic of the NSMS, a designing procedure for the NSMS is proposed. Then the nonlinear dynamic equation of the isolator is established and numerical simulation is performed to obtain the transmissibility. Finally, the detailed design of the HSLDS isolator is given and an experimental setup is proposed. The experimental results demonstrate that the NSMS can reduce the resonance frequency of the isolator indeed; and the isolation performance of the proposed isolator is improved accordingly.

  12. An activity coefficient model for proteins.

    PubMed

    Agena, S M; Bogle, I D; Pessoa, F L

    1997-07-01

    Modeling of the properties of biochemical components is gaining increasing interest due to its potential for further application within the area of biochemical process development. Generally protein solution properties such as protein solubility are expressed through component activity coefficients which are studied here. The original UNIQUAC model is chosen for the representation of protein activity coefficients and, to the best of our knowledge, this is the first time it has been directly applied to protein solutions. Ten different protein-salt-water systems with four different proteins, serum albumin, alphacymotrypsin, beta-lactoglobulin and ovalbumin, are investigated. A root-mean-squared deviation of 0.54% is obtained for the model by comparing calculated protein activity coefficients and protein activity coefficients deduced from osmotic measurements through virial expansion. Model predictions are used to analyze the effect of salt concentrations, pH, salt types, and temperature on protein activity coefficients and also on protein solubility and demonstrate consistency with results from other references. PMID:18636445

  13. Effect of Hybridization on Stiffness Properties of Woven Textile Composites

    NASA Astrophysics Data System (ADS)

    Bejan, Liliana; Taranu, Nicolae; Sîrbu, Adriana

    2013-04-01

    The present study focuses on stiffness properties of woven textile reinforced polymeric composites with respect to hybridization, and geometry of reinforcement. The analyzed composites represent combinations of different fibre materials (E-glass, Kevlar 49, carbon HM) in a predetermined fabric geometry (a plane weave embedded in thermosetting polymeric resin) serving controlled properties and required performance. The effects of hybridization on the stiffness properties of woven textile composites have been studied with respect to the fibres materials, the unbalancing degree of fabrics, and the variation of compactness and undulation of yarns. Some undesirable effects in fabric geometry can be overcome by the combined effects of hybridization and compactness.

  14. Stiffness measurement using terahertz and acoustic waves for biological samples.

    PubMed

    Yoon, Jong-Hyun; Yang, Young-Joong; Park, Jinho; Son, Heyjin; Park, Hochong; Park, Gun-Sik; Ahn, Chang-Beom

    2015-12-14

    A method is proposed to measure sample stiffness using terahertz wave and acoustic stimulation. The stiffness-dependent vibration is measured using terahertz wave (T-ray) during an acoustic stimulation. To quantify the vibration, time of the peak amplitude of the reflected T-ray is measured. In our experiment, the T-ray is asynchronously applied during the period of the acoustic stimulation, and multiple measurements are taken to use the standard deviation and the maximum difference in the peak times to estimate the amplitude of the vibration. Some preliminary results are shown using biological samples. PMID:26699056

  15. Piezooptic Coefficients and Acoustic Wave Velocities in Sn2P2S6 Crystals

    E-print Network

    O. Mys; I. Martynyuk-Lototska; A. Grabar; Yu. Vysochanskii; R. Vlokh

    2007-06-28

    Piezooptic coefficients of Sn2P2S6 crystals are experimentally determined for l=623.8 nm and T=293 K with the aid of interferometric technique. The components of the elastic stiffness tensor for these crystals are calculated on the basis of studies for the acoustic wave velocities. It is shown that acoustooptic figure of merit can achieve extremely high values for Sn2P2S6 crystals (M2 - 2x10-12s3/kg2).

  16. Young modulus dependence of nanoscopic friction coefficient in hard coatings

    E-print Network

    Brune, Harald

    Young modulus dependence of nanoscopic friction coefficient in hard coatings Elisa Riedoa in the friction coefficient can be traced back to variations of the Young modulus. More generally, we show for all to the Young modulus. © 2003 American Institute of Physics. DOI: 10.1063/1.1609234 A fundamental understanding

  17. Factor Scores, Structure and Communality Coefficients: A Primer

    ERIC Educational Resources Information Center

    Odum, Mary

    2011-01-01

    (Purpose) The purpose of this paper is to present an easy-to-understand primer on three important concepts of factor analysis: Factor scores, structure coefficients, and communality coefficients. Given that statistical analyses are a part of a global general linear model (GLM), and utilize weights as an integral part of analyses (Thompson, 2006;…

  18. Flexural stiffnesses of and dimensional stability in circular quasi-isotropic laminate mirrors

    NASA Astrophysics Data System (ADS)

    Kim, Kyung-Pyo

    Composite fiber reinforced plastics are being given favorable consideration for emerging applications in large aperture telescopes, such as the Hubble telescope or communication dishes. Many lightweight mirror fabrication concepts are currently being pursued. Presently, the technology is limited because it has an incomplete understanding of the mechanics associated with quasi-isotropic laminates for diffraction-limited displacement constraints, and lack of understanding for effects of resin buffer layers on composite mirrors for high surface smoothness. In this dissertation document, radial stiffness associated with stacking sequence effects in quasi-isotropic laminates (pi/n, where n=3, 4, and 6) and dimensional stability in the composite laminates are investigated numerically. The numerical results show that directional dependency of flexural stiffness in the laminates, which is strongly associated with stacking sequences, is a significant factor causing unfavorable sinusoidal surface waviness. The maximum radial flexural stiffness variation is found as +/-12.85% in pi/3 laminate while a minimum of +/-5.63% is found in pi/4 laminate. Mechanics of maximum asymmetry by +/-2º misorientation based on ideal pi/n laminate lay-ups are evaluated and the results are compared with ideal lay-up sequence cases. The calculated extensional and flexural stiffness values from the maximum asymmetric cases are within less than 0.05%. As such, the radial flexural stiffness variations in quasi-isotropic laminates are shown to be more problematic than asymmetry caused by common manufacturing variance. The types of surface deformations in quasi-isotropic laminates associated with directional dependency of flexural stiffness are evaluated using finite element analyses. Also, fiber print-through in replicated composite mirrors and the effects of the resin buffer layer present in the mirrors for mitigation of the fiber print-through are investigated and discussed. Numerical results reveal that there will be an unfavorable sinusoidal surface deformation in each ideal p/n laminate and the shapes are strongly associated with principal fiber directions due to stacking sequence effects. The surface deformations in quasi-isotropic laminates are shown to be typical and such surface deformations are inevitable when composite mirrors are fabricated from discrete layers of anisotropic carbon fiber reinforced plastics. Moreover, the use of additional resin layers appears to more adversely influence the composite mirror substrates. The validation of predicted surface deformations and dimensional distortions are achieved by comparing experimental results on a 8-inch-diameter composite mirror sample fabricated at the University of Kansas Dept. of Aerospace Engineering (KUAE) and Bennett Optical Research (BOR). A study of quasi-homogeneous materials such as short fiber products as alternative composite materials is investigated. Furthermore, the relation between resin property effects and corresponding resin thickness effects is evaluated and discussed. The analyses provide information on alternative types of materials that primarily affect optical performance and thus are most important for precision optics. Based on the results, locally varying radial surface deformations in quasi-isotropic laminates fabricated from continuous fiber reinforced plastics distort optical performance. These surface deformations might be eliminated by utilizing short fiber materials and a soft resin system with a very low coefficient of thermal expansion compared to conventional resins.

  19. Exact solutions for free vibration of shear-type structures with arbitrary distribution of mass or stiffness.

    PubMed

    Li, Q S

    2001-10-01

    In this paper, shear-type structures such as frame buildings, etc., are treated as nonuniform shear beams (one-dimensional systems) in free-vibration analysis. The expression for describing the distribution of shear stiffness of a shear beam is arbitrary, and the distribution of mass is expressed as a functional relation with the distribution of shear stiffness, and vice versa. Using appropriate functional transformation, the governing differential equations for free vibration of nonuniform shear beams are reduced to Bessel's equations or ordinary differential equations with constant coefficients for several functional relations. Thus, classes of exact solutions for free vibrations of the shear beam with arbitrary distribution of stiffness or mass are obtained. The effect of taper on natural frequencies of nonuniform beams is investigated. Numerical examples show that the calculated natural frequencies and mode shapes of shear-type structures are in good agreement with the field measured data and those determined by the finite-element method and Ritz method. PMID:11681376

  20. Estimation of deformation and stiffness of fractures close to tunnels using data from single-hole hydraulic testing and grouting

    SciTech Connect

    Fransson, A.; Tsang, C.-F.; Rutqvist, J.; Gustafson, G.

    2010-05-01

    Sealing of tunnels in fractured rocks is commonly performed by pre- or post-excavation grouting. The grouting boreholes are frequently drilled close to the tunnel wall, an area where rock stresses can be low and fractures can more easily open up during grout pressurization. In this paper we suggest that data from hydraulic testing and grouting can be used to identify grout-induced fracture opening, to estimate fracture stiffness of such fractures, and to evaluate its impact on the grout performance. A conceptual model and a method are presented for estimating fracture stiffness. The method is demonstrated using grouting data from four pre-excavation grouting boreholes at a shallow tunnel (50 m) in Nygard, Sweden, and two post-excavation grouting boreholes at a deep tunnel (450 m) in Aespoe HRL, Sweden. The estimated stiffness of intersecting fractures for the boreholes at the shallow Nygard tunnel are low (2-5 GPa/m) and in agreement with literature data from field experiments at other fractured rock sites. Higher stiffness was obtained for the deeper tunnel boreholes at Aespoe which is reasonable considering that generally higher rock stresses are expected at greater depths. Our method of identifying and evaluating the properties and impact of deforming fractures might be most applicable when grouting takes place in boreholes adjacent to the tunnel wall, where local stresses might be low and where deforming (opening) fractures may take most of the grout.

  1. Calculation and measurement of the influence of flow parameters on rotordynamic coefficients in labyrinth seals

    NASA Technical Reports Server (NTRS)

    Kwanka, K.; Ortinger, W.; Steckel, J.

    1994-01-01

    First experimental investigations performed on a new test rig are presented. For a staggered labyrinth seal with fourteen cavities the stiffness coefficient and the leakage flow are measured. The experimental results are compared to calculated results which are obtained by a one-volume bulk-flow theory. A perturbation analysis is made for seven terms. It is found out that the friction factors have great impact on the dynamic coefficients. They are obtained by turbulent flow computation by a finite-volume model with the Reynolds equations used as basic equations.

  2. Symmetry chains and adaptation coefficients

    SciTech Connect

    Fritzer, H.P.; Gruber, B.

    1985-06-01

    Given a symmetry chain of physical significance it becomes necessary to obtain states which transform properly with respect to the symmetries of the chain. In this article we describe a method which permits us to calculate symmetry-adapted quantum states with relative ease. The coefficients for the symmetry-adapted linear combinations are obtained, in numerical form, in terms of the original states of the system and can thus be represented in the form of numerical tables. In addition, one also obtains automatically the matrix elements for the operators of the symmetry groups which are involved, and thus for any physical operator which can be expressed either as an element of the algebra or of the enveloping algebra. The method is well suited for computers once the physically relevant symmetry chain, or chains, have been defined. While the method to be described is generally applicable to any physical system for which semisimple Lie algebras play a role we choose here a familiar example in order to illustrate the method and to illuminate its simplicity. We choose the nuclear shell model for the case of two nucleons with orbital angular momentum l = 1. While the states of the entire shell transform like the smallest spin representation of SO(25) we restrict our attention to its subgroup SU(6) x SU(2)/sub T/. We determine the symmetry chains which lead to total angular momentum SU(2)/sub J/ and obtain the symmetry-adapted states for these chains.

  3. Coefficient Alpha: A Reliability Coefficient for the 21st Century?

    ERIC Educational Resources Information Center

    Yang, Yanyun; Green, Samuel B.

    2011-01-01

    Coefficient alpha is almost universally applied to assess reliability of scales in psychology. We argue that researchers should consider alternatives to coefficient alpha. Our preference is for structural equation modeling (SEM) estimates of reliability because they are informative and allow for an empirical evaluation of the assumptions…

  4. Variable Stiffness Spar Wind-Tunnel Model Development and Testing

    NASA Technical Reports Server (NTRS)

    Florance, James R.; Heeg, Jennifer; Spain, Charles V.; Ivanco, Thomas G.; Wieseman, Carol D.; Lively, Peter S.

    2004-01-01

    The concept of exploiting wing flexibility to improve aerodynamic performance was investigated in the wind tunnel by employing multiple control surfaces and by varying wing structural stiffness via a Variable Stiffness Spar (VSS) mechanism. High design loads compromised the VSS effectiveness because the aerodynamic wind-tunnel model was much stiffer than desired in order to meet the strength requirements. Results from tests of the model include stiffness and modal data, model deformation data, aerodynamic loads, static control surface derivatives, and fuselage standoff pressure data. Effects of the VSS on the stiffness and modal characteristics, lift curve slope, and control surface effectiveness are discussed. The VSS had the most effect on the rolling moment generated by the leading-edge outboard flap at subsonic speeds. The effects of the VSS for the other control surfaces and speed regimes were less. The difficulties encountered and the ability of the VSS to alter the aeroelastic characteristics of the wing emphasize the need for the development of improved design and construction methods for static aeroelastic models. The data collected and presented is valuable in terms of understanding static aeroelastic wind-tunnel model development.

  5. Flexural stiffness of feather shafts: geometry rules over material properties.

    PubMed

    Bachmann, Thomas; Emmerlich, Jens; Baumgartner, Werner; Schneider, Jochen M; Wagner, Hermann

    2012-02-01

    Flight feathers of birds interact with the flow field during flight. They bend and twist under aerodynamic loads. Two parameters are mainly responsible for flexibility in feathers: the elastic modulus (Young's modulus, E) of the material (keratin) and the geometry of the rachises, more precisely the second moment of area (I). Two independent methods were employed to determine Young's modulus of feather rachis keratin. Moreover, the second moment of area and the bending stiffness of feather shafts from fifth primaries of barn owls (Tyto alba) and pigeons (Columba livia) were calculated. These species of birds are of comparable body mass but differ in wing size and flight style. Whether their feather material (keratin) underwent an adaptation in stiffness was previously unknown. This study shows that no significant variation in Young's modulus between the two species exists. However, differences in Young's modulus between proximal and distal feather regions were found in both species. Cross-sections of pigeon rachises were particularly well developed and rich in structural elements, exemplified by dorsal ridges and a well-pronounced transversal septum. In contrast, cross-sections of barn owl rachises were less profiled but had a higher second moment of area. Consequently, the calculated bending stiffness (EI) was higher in barn owls as well. The results show that flexural stiffness is predominantly influenced by the geometry of the feathers rather than by local material properties. PMID:22246249

  6. Design of a Stiff Steerable Grasper for Sinus Surgery

    E-print Network

    Design of a Stiff Steerable Grasper for Sinus Surgery Andria A. Remirez, Ray A. Lathrop, Paul T Background With the advent of endoscopic sinus surgery in the late 1980's [1], a completely new surgical of the sinuses. Today, functional endoscopic sinus surgery (FESS) is commonly used to improve the sinuses

  7. Damping and Stiffness of Particulate SiCInSn Composite

    E-print Network

    Swan Jr., Colby Corson

    is the product of stiffness (Young's modulus E or shear modulus G) and damping (tan ; the loss tangent, which 100 Hz. Composite shear modulus was almost a factor two greater than matrix for 40% and a factor such as high specific modulus, strength, and thermal stability, yet composite design with consideration

  8. Riparian Sediment Delivery Ratio: Stiff Diagrams and Artifical Neural Networks

    EPA Science Inventory

    Various methods are used to estimate sediment transport through riparian buffers and grass jilters with the sediment delivery ratio having been the most widely applied. The U.S. Forest Service developed a sediment delivery ratio using the stiff diagram and a logistic curve to int...

  9. Residual-based Stiffness Estimation in Robots with Flexible Transmissions

    E-print Network

    De Luca, Alessandro

    only the knowledge of the dynamic parameters of the motors. In particular, no extra force/torque generates a residual signal that is a first-order filtered version of the flexibility torque), display nonlinear deformation-torque characteris- tics, or be part of a nonlinear variable stiffness

  10. Design optimization of a twist compliant mechanism with nonlinear stiffness

    NASA Astrophysics Data System (ADS)

    Tummala, Y.; Frecker, M. I.; Wissa, A. A.; Hubbard, J. E., Jr.

    2014-10-01

    A contact-aided compliant mechanism called a twist compliant mechanism (TCM) is presented in this paper. This mechanism has nonlinear stiffness when it is twisted in both directions along its axis. The inner core of the mechanism is primarily responsible for its flexibility in one twisting direction. The contact surfaces of the cross-members and compliant sectors are primarily responsible for its high stiffness in the opposite direction. A desired twist angle in a given direction can be achieved by tailoring the stiffness of a TCM. The stiffness of a compliant twist mechanism can be tailored by varying thickness of its cross-members, thickness of the core and thickness of its sectors. A multi-objective optimization problem with three objective functions is proposed in this paper, and used to design an optimal TCM with desired twist angle. The objective functions are to minimize the mass and maximum von-Mises stress observed, while minimizing or maximizing the twist angles under specific loading conditions. The multi-objective optimization problem proposed in this paper is solved for an ornithopter flight research platform as a case study, with the goal of using the TCM to achieve passive twisting of the wing during upstroke, while keeping the wing fully extended and rigid during the downstroke. Prototype TCMs have been fabricated using 3D printing and tested. Testing results are also presented in this paper.

  11. Substrate stiffness affects skeletal myoblast differentiation in vitro

    NASA Astrophysics Data System (ADS)

    Romanazzo, Sara; Forte, Giancarlo; Ebara, Mitsuhiro; Uto, Koichiro; Pagliari, Stefania; Aoyagi, Takao; Traversa, Enrico; Taniguchi, Akiyoshi

    2012-12-01

    To maximize the therapeutic efficacy of cardiac muscle constructs produced by stem cells and tissue engineering protocols, suitable scaffolds should be designed to recapitulate all the characteristics of native muscle and mimic the microenvironment encountered by cells in vivo. Moreover, so not to interfere with cardiac contractility, the scaffold should be deformable enough to withstand muscle contraction. Recently, it was suggested that the mechanical properties of scaffolds can interfere with stem/progenitor cell functions, and thus careful consideration is required when choosing polymers for targeted applications. In this study, cross-linked poly-?-caprolactone membranes having similar chemical composition and controlled stiffness in a supra-physiological range were challenged with two sources of myoblasts to evaluate the suitability of substrates with different stiffness for cell adhesion, proliferation and differentiation. Furthermore, muscle-specific and non-related feeder layers were prepared on stiff surfaces to reveal the contribution of biological and mechanical cues to skeletal muscle progenitor differentiation. We demonstrated that substrate stiffness does affect myogenic differentiation, meaning that softer substrates can promote differentiation and that a muscle-specific feeder layer can improve the degree of maturation in skeletal muscle stem cells.

  12. ANISOTROPIC STEP STIFFNESS FROM A KINETIC MODEL OF EPITAXIAL GROWTH

    E-print Network

    Ferguson, Thomas S.

    . In epitax- ial growth, crystal surface features such as thin films, which are building blocks of solidANISOTROPIC STEP STIFFNESS FROM A KINETIC MODEL OF EPITAXIAL GROWTH RUSSEL E. CAFLISCH of the step edge orientation angle, . Basic ingredients of the model are: (i) the diffusion of point defects

  13. Variable stiffness and damping suspension system for train

    NASA Astrophysics Data System (ADS)

    Sun, Shuaishuai; Deng, Huaxia; Li, Weihua

    2014-03-01

    As the vibration of high speed train becomes fierce when the train runs at high speed, it is crucial to develop a novel suspension system to negotiate train's vibration. This paper presents a novel suspension based on Magnetorheological fluid (MRF) damper and MRF based smart air spring. The MRF damper is used to generate variable damping while the smart air spring is used to generate field-dependent stiffness. In this paper, the two kind smart devices, MRF dampers and smart air spring, are developed firstly. Then the dynamic performances of these two devices are tested by MTS. Based on the testing results, the two devices are equipped to a high speed train which is built in ADAMS. The skyhook control algorithm is employed to control the novel suspension. In order to compare the vibration suppression capability of the novel suspension with other kind suspensions, three other different suspension systems are also considered and simulated in this paper. The other three kind suspensions are variable damping with fixed stiffness suspension, variable stiffness with fixed damping suspension and passive suspension. The simulation results indicate that the variable damping and stiffness suspension suppresses the vibration of high speed train better than the other three suspension systems.

  14. THE STIFFNESS OF THE FLAGELLA OF IMPALED BULL SPERM

    E-print Network

    Lindemann, Charles

    methylsulfonate, 0.163 M sucrose, 0.005 M magnesium sulfate, 2-5 uM calcium chloride, 0.007 M sodium lactate direct analytical treatment of the experimental system. The effects of external ATP and ADP were measured, 1971, 1972 a and c). The effect of ATP and ADP on stiffness is presently reported. METHODS Bull semen

  15. Magnetorheological brush - a soft structure with highly tuneable stiffness.

    PubMed

    Huang, Xiao; Mohla, Akshi; Hong, Wei; Bastawros, Ashraf F; Feng, Xi-Qiao

    2014-03-14

    By combining the field-stiffening effect of magnetorheological (MR) elastomers and the Euler buckling mechanism, we developed a brush-like magneto-active structure with highly tuneable stiffness. When the applied mechanical load is within a certain range, the effective stiffness of the structure can be tuned by several orders of magnitude with the applied magnetic field. The performance of the structure and its dependence on various synthesis parameters, such as the curing field and filler concentration, were investigated experimentally. It is found that the increase in the critical load for buckling is more than the contribution from the stiffening of the MR elastomer. To unravel the relationship between the stiffness increase and the applied field, a theoretical model with coupled mechanical deformation and magnetic field is established. The prediction of the model agrees well with experimental results. The theory may also be used to model the behaviour of other similar materials, such as MR gels. The MR brush developed in this research holds promise for potential applications in smart structures or devices that require mechanical stiffness to be tuneable in a relatively large range. As the amplification mechanism is independent of the base material, it could be used in conjunction with emerging MR materials for further enhanced performance. PMID:24652105

  16. Automated Liver Stiffness Measurements with Magnetic Resonance Elastography

    PubMed Central

    Dzyubak, Bogdan; Glaser, Kevin; Yin, Meng; Talwalkar, Jayant; Chen, Jun; Manduca, Armando; Ehman, Richard L.

    2012-01-01

    Purpose To provide a fully-automated algorithm for obtaining stiffness measurements from hepatic MR Elastography images that are consistent with measurements performed by expert readers. Materials and Methods An initial liver contour was found using an adaptive threshold and expanded using an active contour to select a homogeneous area of the liver. The confidence map generated during the stiffness calculation was used to select a region of reliable wave propagation. The average stiffness within the automatically-generated ROI was compared to measurements by two trained readers in a set of 88 clinical test cases ranging from healthy to severely fibrotic. Results The stiffness measurements reported by the readers differed by ?6.76% ± 22.8 % (95% confidence) and had an ICC of 0.972 (p<0.05).The algorithm and the more experienced reader differed by 4.32% ± 14.9 with an ICC of 0.987. Conclusion The automated algorithm performed reliably, even though MRE acquisitions often have motion artifacts present. The correlation between the automated measurements and those from the trained readers was superior to the correlation between the readers. PMID:23281171

  17. Stiffness analysis for the micromagnetic standard problem No. 4

    SciTech Connect

    Tsiantos, Vassilios D.; Suess, Dieter; Schrefl, Thomas; Fidler, Josef

    2001-06-01

    In this article solutions to micromagnetic standard problem No. 4, a 500-nm{times}125-nm-wide NiFe film, are presented. A three-dimensional-finite element simulation based on the solution of the Gilbert equation has been used. The simulations show that two different reversal mechanisms occur for the two different applied fields. For a field at 170{degree} counterclockwise from the saturation direction there is a nonuniform rotation of magnetization towards the direction of the applied field, with the magnetization at the ends rotating faster than the magnetization in the center. For a field at 190{degree} counterclockwise from the saturation direction the magnetization at the ends and in the center rotate in opposite directions leading to the formation of a 360{degree} wall after 0.22 ns associated with a peak in the exchange energy. Moreover, the time for the magnetization component parallel to the long axis to cross the zero is 0.136 and 0.135 ns for field 1 and field 2, respectively. The stiffness of the problem has been investigated solving the system of ordinary differential equations with a nonstiff method (Adams) and a stiff one (backward differentiation formula, BDF). For the measure of stiffness the ratio of the total number of time steps (nst) taken by the two solvers, that is nst(Adams)/nst(BDF), has been used. This ratio is 0.784 for field 1 and 0.593 for field 2, which means that the nonstiff method (Adams) uses larger time steps than the stiff method (BDF) and consequently the systems are not stiff. The average time step for the Adams method was 0.2 ps for both fields. {copyright} 2001 American Institute of Physics.

  18. An acoustic startle alters knee joint stiffness and neuromuscular control.

    PubMed

    DeAngelis, A I; Needle, A R; Kaminski, T W; Royer, T R; Knight, C A; Swanik, C B

    2015-08-01

    Growing evidence suggests that the nervous system contributes to non-contact knee ligament injury, but limited evidence has measured the effect of extrinsic events on joint stability. Following unanticipated events, the startle reflex leads to universal stiffening of the limbs, but no studies have investigated how an acoustic startle influences knee stiffness and muscle activation during a dynamic knee perturbation. Thirty-six individuals were tested for knee stiffness and muscle activation of the quadriceps and hamstrings. Subjects were seated and instructed to resist a 40-degree knee flexion perturbation from a relaxed state. During some trials, an acoustic startle (50?ms, 1000?Hz, 100?dB) was applied 100?ms prior to the perturbation. Knee stiffness, muscle amplitude, and timing were quantified across time, muscle, and startle conditions. The acoustic startle increased short-range (no startle: 0.044?±?0.011?N·m/deg/kg; average startle: 0.047?±?0.01?N·m/deg/kg) and total knee stiffness (no startle: 0.036?±?0.01?N·m/deg/kg; first startle 0.027?±?0.02?N·m/deg/kg). Additionally, the startle contributed to decreased [vastus medialis (VM): 13.76?±?33.6%; vastus lateralis (VL): 6.72?±?37.4%] but earlier (VM: 0.133?±?0.17?s; VL: 0.124?±?0.17?s) activation of the quadriceps muscles. The results of this study indicate that the startle response can significantly disrupt knee stiffness regulation required to maintain joint stability. Further studies should explore the role of unanticipated events on unintentional injury. PMID:25212407

  19. Predictors of Postoperative Finger Stiffness in Unstable Proximal Phalangeal Fractures

    PubMed Central

    Onishi, Tadanobu; Shimizu, Takamasa; Fujitani, Ryotaro; Shigematsu, Koji; Tanaka, Yasuhito

    2015-01-01

    Background: The purpose of this study was to determine the risk factors for postoperative finger stiffness after open reduction and internal fixation of unstable proximal phalangeal fractures using a low-profile plate and/or screw system. We hypothesized that dorsal plate placement is a risk factor for postoperative finger stiffness. Methods: Seventy consecutive patients (50 men, 20 women; average age, 40 years) with 75 unstable proximal phalangeal fractures were treated with titanium plates and/or screws and evaluated at a minimum follow-up of 1 year. Thirty-six comminuted fractures and 24 intra-articular fractures were included, and 16 fractures had associated soft-tissue injuries. Plate fixation was performed in 59 fractures, and the remaining 16 were fixed with screws only. The implants were placed in a dorsal location in 33 fractures and in a lateral or volar location in 42 fractures. Finger stiffness was defined as a total active range of finger motion <80% for the treated finger. Univariate and multivariate analyses were performed on 8 variables: patient characteristics (age and sex), fracture characteristics (fracture comminution, joint involvement, and associated soft-tissue injury), and surgical characteristics (type and location of implants and removal of the implants). Results: Postoperative finger stiffness occurred in 38 fractures. The multivariate analysis indicated that plate fixation (odds ratio, 5.9; 95% confidence interval, 1.5–24.0; P = 0.01) and dorsal placement (odds ratio, 3.0; 95% confidence interval, 1.1–8.3; P = 0.03) were independent risk factors for finger stiffness. Conclusion: We recommend the use of screw fixation as much as possible for unstable proximal phalangeal fractures using a midlateral approach. PMID:26180732

  20. Annular honeycomb seals: Test results for leakage and rotordynamic coefficients; comparisons to labyrinth and smooth configurations

    NASA Technical Reports Server (NTRS)

    Childs, Dara W.; Elrod, David; Hale, Keith

    1989-01-01

    Test results are presented for leakage and rotordynamic coefficients for seven honeycomb seals. All seals have the same radius, length, and clearance; however, the cell depths and diameters are varied. Rotordynamic data, which are presented, consist of the direct and cross-coupled stiffness coefficients and the direct damping coefficients. The rotordynamic-coefficient data show a considerable sensitivity to changes in cell dimensions; however, no clear trends are identifiable. Comparisons of test data for the honeycomb seals with labyrinth and smooth annular seals show the honeycomb seal had the best sealing (minimum leakage) performance, followed in order by the labyrinth and smooth seals. For prerotated fluid entering the seal, in the direction of shaft rotation, the honeycomb seal has the best rotordynamic stability followed in order by the labyrinth and smooth. For no prerotation, or fluid prerotation against shaft rotation, the labyrinth seal has the best rotordynamic stability followed in order by the smooth and honeycomb seals.

  1. Annular honeycomb seals: Test results for leakage and rotordynamic coefficients - Comparisons to labyrinth and smooth configurations

    NASA Technical Reports Server (NTRS)

    Childs, D.; Elrod, D.; Hale, K.

    1989-01-01

    Test results are presented for leakage and rotordynamic coefficients for seven honeycomb seals. All seals have the same radius, length, and clearance; however, the cell depths and diameters are varied. Rotordynamic data, which are presented, consist of the direct and cross-coupled stiffness coefficients and the direct damping coefficients. The rotordynamic-coefficient data show a considerable sensitivity to changes in cell dimensions; however, no clear trends are identifiable. Comparisons of test data for the honeycomb seals with labyrinth and smooth annular seals shows the honeycomb seal had the best sealing (minimum leakage) performance, followed in order by the labyrinth and smooth seals. For prerotated fluids entering the seal, in the direction of shaft rotation, the honeycomb seal has the best rotordynamic stability followed in order by the labyrinth and smooth. For no prerotation, or fluid prerotation against shaft rotation, the labyrinth seal has the best rotordynamic stability followed in order by the smooth and honeycomb seals.

  2. Planck radiation law and Einstein coefficients reexamined in Kaniadakis ? statistics.

    PubMed

    Ourabah, Kamel; Tribeche, Mouloud

    2014-06-01

    Blackbody radiation is reconsidered using the counterpart of the Bose-Einstein distribution in the ? statistics arising from the Kaniadakis entropy. The generalized Planck radiation law is presented and compared to the usual law, to which it reduces in the limiting case ??0. Effective Einstein's coefficients of emission and absorption are defined in terms of the Kaniadakis parameter ?. It is shown that the Kaniadakis statistics keeps unchanged the first Einstein coefficient A while the second coefficient B admits a generalized form within the present theoretical framework. PMID:25019747

  3. Procrustes Matching by Congruence Coefficients

    ERIC Educational Resources Information Center

    Korth, Bruce; Tucker, L. R.

    1976-01-01

    Matching by Procrustes methods involves the transformation of one matrix to match with another. A special least squares criterion, the congruence coefficient, has advantages as a criterion for some factor analytic interpretations. A Procrustes method maximizing the congruence coefficient is given. (Author/JKS)

  4. Muscle short-range stiffness can be used to1 estimate the endpoint stiffness of the human arm2

    E-print Network

    Perreault, Eric J.

    , Chicago, IL, USA9 4 Research Service, Edward Hines, Jr. VA Hospital, Hines, IL, USA10 11 12 Running title relevant for the maintenance of posture. At a fixed posture, endpoint32 stiffness can be regulated range of43 evaluated arm postures and voluntary forces, the musculoskeletal model incorporating44 short

  5. Spin-wave stiffness parameter in ferrimagnetic systems: Nanoparticulate powders of (Mg,Zn ) Fe2O4 mixed ferrites

    NASA Astrophysics Data System (ADS)

    Franco, A.; Pessoni, H. V. S.; Machado, F. L. A.

    2015-11-01

    We have evaluated the spin-wave stiffness parameter in nanoparticulate powders of Mg1 -xZnxFe2O4 ( 0.0 ?x ?0.6 ) mixed ferrites from magnetization data obtained at two different ranges of temperature: 5 -300 K and 300 -750 K . At the lower temperature range the T-dependence of the saturation magnetization, Ms, data could be fitted to the Bloch's law with T3 /2 . The spin-wave stiffness parameters D were determined from the coefficient of T3 /2 ; being ˜132 and ˜86 meVÅ for x = 0.0 and 0.6, respectively, with the corresponding exchange constant JAB of ˜1.10 and ˜0.72 meV , respectively. The values of D determined from the experimental Curie temperature Tc were ˜212 and ˜163 meVÅ2 for x = 0.0 and 0.6, respectively, with the corresponding exchange constant JAB of ˜1.77 and ˜1.30 meV . The difference in both JAB and D values obtained from the coefficient of T3 /2 and from Tc may be attributed to the fact that the magnetic measurements were performed at a different range of temperatures. The results are discussed in terms of the cation distribution among A- and B-sites of occupation on these spinel ferrites.

  6. On the role of CFRP reinforcement for wood beams stiffness

    NASA Astrophysics Data System (ADS)

    Ianasi, A. C.

    2015-11-01

    In recent years, carbon fiber composites have been increasingly used in different ways in reinforcing structural elements. Specifically, the use of composite materials as a reinforcement for wood beams under bending loads requires paying attention to several aspects of the problem such as the number of the composite layers applied on the wood beams. Study consolidation of composites revealed that they are made by bonding fibrous material impregnated with resin on the surface of various elements, to restore or increase the load carrying capacity (bending, cutting, compression or torque) without significant damage of their rigidity. Fibers used in building applications can be fiberglass, aramid or carbon. Items that can be strengthened are concrete, brick, wood, steel and stone, and in terms of structural beams, walls, columns and floors. This paper describes an experimental study which was designed to evaluate the effect of composite material on the stiffness of the wood beams. It proposes a summary of the fundamental principles of analysis of composite materials and the design and use. The type of reinforcement used on the beams is the carbon fiber reinforced polymer (CFRP) sheet and plates and also an epoxy resin for bonding all the elements. Structural epoxy resins remain the primary choice of adhesive to form the bond to fiber-reinforced plastics and are the generally accepted adhesives in bonded CFRP-wood connections. The advantages of using epoxy resin in comparison to common wood-laminating adhesives are their gap-filling qualities and the low clamping pressures that are required to form the bond between carbon fiber plates or sheets and the wood beams. Mechanical tests performed on the reinforced wood beams showed that CFRP materials may produce flexural displacement and lifting increases of the beams. Observations of the experimental load-displacement relationships showed that bending strength increased for wood beams reinforced with CFRP composite plates and sheets compared to those without CFRP reinforcement. The main conclusion of the tests is that the tensioning forces allow beam taking a maximum load for a while, something that is particularly useful when we consider a real construction, so in case of excess lift beam, we have time to take strengthening measures and when is about a catastrophic request (earthquake) the construction remain partially functional. The experiments have shown that the method of increasing resistance of wood constructions with composite materials is good for it. The solution is easy to implement and has low costs.

  7. Clinical Significance of Pre-Transplant Arterial Stiffness and the Impact of Kidney Transplantation on Arterial Stiffness

    PubMed Central

    Kim, Hyun Seon; Seung, Jaeho; Lee, Ju Hyun; Chung, Byung Ha; Yang, Chul Woo

    2015-01-01

    Background Arterial stiffness is closely associated with cardiovascular disease (CVD) in end stage renal disease (ESRD) patients. However, the clinical significance of pre-transplant arterial stiffness and the impact of kidney transplantation (KT) on arterial stiffness have not yet been determined. Method We measured the brachial-ankle pulse wave velocity (baPWV) before KT and one year after KT. We evaluated the potential utility of pre-transplant baPWV as a screening test to predict CVD. The impact of KT on progression of arterial stiffness was evaluated according to changes in baPWV after KT. The factors that influence the change of baPWV after KT were also examined. Result The mean value of pre-transplant baPWV was 1508 ± 300 cm/s in ESRD patients; 93.4% had a higher baPWV value than healthy controls. Pre-transplant baPWV was higher in patients with CVD than in those without CVD (1800 ± 440 vs. 1491 ± 265 cm/s, p<0.05), and was a strong predictive factor of CVD (OR 1.003, p<0.05). The optimal cut-off value of baPWV for the detection of CVD was 1591 cm/s, and this value was an independent predictor of CVD in KT recipients (OR 6.3, p<0.05). The post-transplant baPWV was significantly decreased compared to that of pre-transplant rates (1418 ± 235 vs. 1517 ± 293 cm/s, p<0.05), and progression of arterial stiffness was not observed in 86.9% patients. Logistic regression analysis revealed that higher body mass index and the degree of increase in calcium levels were independent risk factors that affected baPWV after KT. Conclusions Evaluation of arterial stiffness with baPWV is a useful screening test for predicting CVD after KT, and KT is effective in preventing the progression of arterial stiffness in ESRD patients. PMID:26406607

  8. Helix versus coil polypeptide macromers: gel networks with decoupled stiffness and permeability

    E-print Network

    Oelker, Abigail M.

    As a platform for investigating the individual effects of substrate stiffness, permeability, and ligand density on cellular behavior, we developed a set of hydrogels with stiffness tuned by polymer backbone rigidity, ...

  9. jamSheets: Thin Interfaces with Tunable Stiffness Enabled by Layer Jamming

    E-print Network

    Ou, Jifei

    This works introduces layer jamming as an enabling technology for designing deformable, stiffness-tunable, thin sheet interfaces. Interfaces that exhibit tunable stiffness properties can yield dynamic haptic feedback and ...

  10. Effects of mechanical forces on cytoskeletal remodeling and stiffness of cultured smooth muscle cells 

    E-print Network

    Na, Sungsoo

    2009-06-02

    that disruption of the actin filaments can reduce the stiffness substantially, whereas there can be little contribution to the overall cell stiffness by the microtubules or intermediate filaments. To investigate the effect of mechanical stretching on cytoskeletal...

  11. RESEARCH PAPER Stress-induced anisotropy in granular materials: fabric, stiffness,

    E-print Network

    Salzman, Daniel

    RESEARCH PAPER Stress-induced anisotropy in granular materials: fabric, stiffness, and permeability arrangement (fabric) and of the material's strength, incremental stiffness, and permeability. Thirteen measures of fabric anisotropy are developed, which are arranged in four categories: as preferred orien

  12. Zero finite-temperature charge stiffness within the half-filled 1D Hubbard model

    SciTech Connect

    Carmelo, J.M.P.; Beijing Computational Science Research Center, Beijing 100084; Institut für Theoretische Physik III, Universität Stuttgart, D-70550 Stuttgart ; Gu, Shi-Jian; Department of Physics and ITP, Chinese University of Hong Kong, Hong Kong ; Sacramento, P.D.; Beijing Computational Science Research Center, Beijing 100084

    2013-12-15

    Even though the one-dimensional (1D) Hubbard model is solvable by the Bethe ansatz, at half-filling its finite-temperature T>0 transport properties remain poorly understood. In this paper we combine that solution with symmetry to show that within that prominent T=0 1D insulator the charge stiffness D(T) vanishes for T>0 and finite values of the on-site repulsion U in the thermodynamic limit. This result is exact and clarifies a long-standing open problem. It rules out that at half-filling the model is an ideal conductor in the thermodynamic limit. Whether at finite T and U>0 it is an ideal insulator or a normal resistor remains an open question. That at half-filling the charge stiffness is finite at U=0 and vanishes for U>0 is found to result from a general transition from a conductor to an insulator or resistor occurring at U=U{sub c}=0 for all finite temperatures T>0. (At T=0 such a transition is the quantum metal to Mott–Hubbard-insulator transition.) The interplay of the ?-spin SU(2) symmetry with the hidden U(1) symmetry beyond SO(4) is found to play a central role in the unusual finite-temperature charge transport properties of the 1D half-filled Hubbard model. -- Highlights: •The charge stiffness of the half-filled 1D Hubbard model is evaluated. •Its value is controlled by the model symmetry operator algebras. •We find that there is no charge ballistic transport at finite temperatures T>0. •The hidden U(1) symmetry controls the U=0 phase transition for T>0.

  13. Arterial stiffness identification of the human carotid artery using the stressstrain relationship in vivo

    E-print Network

    Konofagou, Elisa E.

    Arterial stiffness identification of the human carotid artery using the stress­strain relationship in revised form 20 September 2011 Accepted 20 September 2011 Available online xxxx Keywords: Arterial stiffness Carotid artery Collagen Elastin Stress­strain relationship a b s t r a c t Arterial stiffness

  14. Assessment of a portable device for the quantitative measurement of ankle joint stiffness in spastic individuals

    E-print Network

    Gorassini, Monica

    Assessment of a portable device for the quantitative measurement of ankle joint stiffness-rater reliability. The device could easily distinguish between stiff and control ankle joints. A portable device can be a useful diagnostic tool to obtain reliable information of stiffness for the ankle joint. a b

  15. Cytoplasmic hydrogen ion diffusion coefficient.

    PubMed Central

    al-Baldawi, N F; Abercrombie, R F

    1992-01-01

    The apparent cytoplasmic proton diffusion coefficient was measured using pH electrodes and samples of cytoplasm extracted from the giant neuron of a marine invertebrate. By suddenly changing the pH at one surface of the sample and recording the relaxation of pH within the sample, an apparent diffusion coefficient of 1.4 +/- 0.5 x 10(-6) cm2/s (N = 7) was measured in the acidic or neutral range of pH (6.0-7.2). This value is approximately 5x lower than the diffusion coefficient of the mobile pH buffers (approximately 8 x 10(-6) cm2/s) and approximately 68x lower than the diffusion coefficient of the hydronium ion (93 x 10(-6) cm2/s). A mobile pH buffer (approximately 15% of the buffering power) and an immobile buffer (approximately 85% of the buffering power) could quantitatively account for the results at acidic or neutral pH. At alkaline pH (8.2-8.6), the apparent proton diffusion coefficient increased to 4.1 +/- 0.8 x 10(-6) cm2/s (N = 7). This larger diffusion coefficient at alkaline pH could be explained quantitatively by the enhanced buffering power of the mobile amino acids. Under the conditions of these experiments, it is unlikely that hydroxide movement influences the apparent hydrogen ion diffusion coefficient. PMID:1617134

  16. 35:6177, 1996 (2000) 61Journal of Research on the Lepidoptera 35:6177, 1996 (2000) Flexural stiffness patterns of butterfly wings (Papilionoidea)

    E-print Network

    Steppan, Scott

    2000-01-01

    to nearly the fourth power (pw 3.9 ) and is highly correlated with wing area cubed (S3.1 ). The generalized stiffness patterns of butterfly wings (Papilionoidea) Scott J. Steppan Committee on Evolutionary Biology generates aerodynamic forces through the ac- tive manipulation of the wing and the "passive" properties

  17. Optimal design of variable-stiffness fiber-reinforced composites using cellular automata

    NASA Astrophysics Data System (ADS)

    Setoodeh, Shahriar

    The growing number of applications of composite materials in aerospace and naval structures along with advancements in manufacturing technologies demand continuous innovations in the design of composite structures. In the traditional design of composite laminates, fiber orientation angles are constant for each layer and are usually limited to 0, 90, and +/-45 degrees. To fully benefit from the directional properties of composite laminates, such limitations have to be removed. The concept of variable-stiffness laminates allows the stiffness properties to vary spatially over the laminate. Through tailoring of fiber orientations and laminate thickness spatially in an optimal fashion, mechanical properties of a part can be improved. In this thesis, the optimal design of variable-stiffness fiber-reinforced composite laminates is studied using an emerging numerical engineering optimization scheme based on the cellular automata paradigm. A cellular automaton (CA) based design scheme uses local update rule for both field variables (displacements) and design variables (lay-up configuration and laminate density measure) in an iterative fashion to convergence to an optimal design. In the present work, the displacements are updated based on the principle of local equilibrium and the design variables are updated according to the optimality criteria for minimum compliance design. A closed form displacement update rule for constant thickness isotropic continua is derived, while for the general anisotropic continua with variable thickness a numeric update rule is used. Combined lay-up and topology design of variable-stiffness flat laminates is performed under the action of in-plane loads and bending loads. An optimality criteria based formulation is used to obtain local design rules for minimum compliance design subject to a volume constraint. It is shown that the design rule splits into a two step application. In the first step an optimal lay-up configuration is computed and in the second step the density measure is obtained. The spatial lay-up design problem is formulated using both fiber angles and lamination parameters as design variables. A weighted average formulation is used to handle multiple load case designs. Numerical studies investigate the performance of the proposed design methodology. The optimal lay-up configuration is independent of the lattice density with more details emerging as the density is increased. Moreover, combined topology and lay-up designs are free of checkerboard patterns. (Abstract shortened by UMI.)

  18. Spurious Behavior of Shock-Capturing Methods: Problems Containing Stiff Source Terms and Discontinuities

    NASA Technical Reports Server (NTRS)

    Yee, Helen M. C.; Kotov, D. V.; Wang, Wei; Shu, Chi-Wang

    2013-01-01

    The goal of this paper is to relate numerical dissipations that are inherited in high order shock-capturing schemes with the onset of wrong propagation speed of discontinuities. For pointwise evaluation of the source term, previous studies indicated that the phenomenon of wrong propagation speed of discontinuities is connected with the smearing of the discontinuity caused by the discretization of the advection term. The smearing introduces a nonequilibrium state into the calculation. Thus as soon as a nonequilibrium value is introduced in this manner, the source term turns on and immediately restores equilibrium, while at the same time shifting the discontinuity to a cell boundary. The present study is to show that the degree of wrong propagation speed of discontinuities is highly dependent on the accuracy of the numerical method. The manner in which the smearing of discontinuities is contained by the numerical method and the overall amount of numerical dissipation being employed play major roles. Moreover, employing finite time steps and grid spacings that are below the standard Courant-Friedrich-Levy (CFL) limit on shockcapturing methods for compressible Euler and Navier-Stokes equations containing stiff reacting source terms and discontinuities reveals surprising counter-intuitive results. Unlike non-reacting flows, for stiff reactions with discontinuities, employing a time step and grid spacing that are below the CFL limit (based on the homogeneous part or non-reacting part of the governing equations) does not guarantee a correct solution of the chosen governing equations. Instead, depending on the numerical method, time step and grid spacing, the numerical simulation may lead to (a) the correct solution (within the truncation error of the scheme), (b) a divergent solution, (c) a wrong propagation speed of discontinuities solution or (d) other spurious solutions that are solutions of the discretized counterparts but are not solutions of the governing equations. The present investigation for three very different stiff system cases confirms some of the findings of Lafon & Yee (1996) and LeVeque & Yee (1990) for a model scalar PDE. The findings might shed some light on the reported difficulties in numerical combustion and problems with stiff nonlinear (homogeneous) source terms and discontinuities in general.

  19. Vibration in Planetary Gear Systems with Unequal Planet Stiffnesses

    NASA Technical Reports Server (NTRS)

    Frater, J. L.; August, R.; Oswald, F. B.

    1982-01-01

    An algorithm suitable for a minicomputer was developed for finding the natural frequencies and mode shapes of a planetary gear system which has unequal stiffnesses between the Sun/planet and planet/ring gear meshes. Mode shapes are represented in the form of graphical computer output that illustrates the lateral and rotational motion of the three coaxial gears and the planet gears. This procedure permits the analysis of gear trains utilizing nonuniform mesh conditions and user specified masses, stiffnesses, and boundary conditions. Numerical integration of the equations of motion for planetary gear systems indicates that this algorithm offers an efficient means of predicting operating speeds which may result in high dynamic tooth loads.

  20. Stabilized multilevel Monte Carlo method for stiff stochastic differential equations

    SciTech Connect

    Abdulle, Assyr Blumenthal, Adrian

    2013-10-15

    A multilevel Monte Carlo (MLMC) method for mean square stable stochastic differential equations with multiple scales is proposed. For such problems, that we call stiff, the performance of MLMC methods based on classical explicit methods deteriorates because of the time step restriction to resolve the fastest scales that prevents to exploit all the levels of the MLMC approach. We show that by switching to explicit stabilized stochastic methods and balancing the stabilization procedure simultaneously with the hierarchical sampling strategy of MLMC methods, the computational cost for stiff systems is significantly reduced, while keeping the computational algorithm fully explicit and easy to implement. Numerical experiments on linear and nonlinear stochastic differential equations and on a stochastic partial differential equation illustrate the performance of the stabilized MLMC method and corroborate our theoretical findings.

  1. Stiffness Study of Wound-Filament Pressure Vessels

    NASA Technical Reports Server (NTRS)

    Verderaime, V.

    1986-01-01

    Report presents theoretical and experimental study of stiffness of lightweight, jointed pressure vessels made of wound graphite fibers and epoxy. Specimens fabricated from layers of graphite fibers, wet with epoxy, on aluminum mandrel. Segment ends thickened with interspersed layers of axially oriented fibers to reduce pinhole bearing stresses and local deformations. Segments cured at 390 degrees F (199 degrees C). Report presents results of vibrational tests of one-quarter-scale models of wound-filament pressure vessels.

  2. Compact, Stiff, Remotely-Actuable Quick-Release Clamp

    NASA Technical Reports Server (NTRS)

    Tsai, Ted W. (Inventor)

    2000-01-01

    The present invention provides a clamp that is compact and lightweight, yet provides high holding strength and stiffness or rigidity. The clamp uses a unique double slant interface design which provides mechanical advantages to resist forces applied to the clamp member as the load increases. The clamp allows for rapid and remote-activated release of the clamp jaws by applying only a small operating force to an over-center lock/release mechanism, such as by pulling a manual tether.

  3. Development of a variable stiffness spring for adaptive vibration isolators

    NASA Astrophysics Data System (ADS)

    Cronje, Johan M.; Heyns, P. S.; Theron, Nico J.; Loveday, Philip W.

    2004-07-01

    Variable stiffness springs allow vibration absorbers and isolators to adapt to changing operating conditions. This paper describes the development of such a spring. The spring was a compound leaf spring and variable stiffness was achieved by separating the two leaf springs using a wax actuator. In the selected design, each spring consisted of an outer (220mm in diameter) and an inner ring connected by three radial beams. A paraffin wax actuator was chosen to affect the separation of the leaf springs. This actuator consisted of a small copper cup containing paraffin wax. When the wax is heated, it changes from a solid to a liquid with an associated volume change that is used to drive an output shaft. A hot-air gun was used to heat and cool the wax actuator. It was found that the wax actuator could produce an 8mm separation of the springs, which increased the stiffness of the spring by 2.7 times, exceeding the typical requirement for adaptive absorbers and isolators. The loss factor, of the variable stiffness spring, was less than 0.12. The measured response times for the open-loop system were 82s and 109s for heating and cooling respectively. A linear sliding potentiometer was used to measure the spring separation and proportional and derivative feedback control was used to control the current supplied to the heating element thus reducing the response time to less than 30s for small step changes. Further improvement in response time could be achieved by more directly heating and cooling of the paraffin wax in the actuator.

  4. High stiffness seals for rotor critical speed control

    NASA Technical Reports Server (NTRS)

    Fleming, D. P.

    1977-01-01

    An annular seal is analyzed in which the inlet clearance is larger than the outlet clearance; the flow path may be either stepped or tapered. This design produces radial stiffness 1.7 to 14 times that of a constant clearance seal having the same minimum clearance. When sealing high pressure fluids, such a seal improves rotor stability and can be used to shift troublesome critical speeds to a more suitable location.

  5. High stiffness seals for rotor critical speed control

    NASA Technical Reports Server (NTRS)

    Fleming, D. P.

    1977-01-01

    An annular seal is analyzed in which the inlet clearance is larger than the outlet clearance; the flow path may be either stepped or tapered. This design produces radial stiffnesses 1.7 to 14 times that of a constant-clearance seal having the same minimum clearance. When sealing high-pressure fluids, such as a seal can improve rotor stability and can be used to shift troublesome critical speeds to a more suitable location.

  6. Unexpected swelling of stiff DNA in a polydisperse crowded environment

    E-print Network

    Hongsuk Kang; Ngo Minh Toan; Changbong Hyeon; D. Thirumalai

    2015-08-13

    We investigate the conformations of DNA-like stiff chains, characterized by contour length ($L$) and persistence length ($l_p$), in a variety of crowded environments containing mono disperse soft spherical (SS) and spherocylindrical (SC) particles, mixture of SS and SC, and a milieu mimicking the composition of proteins in $E. coli.$ cytoplasm. The stiff chain, whose size modestly increases in SS crowders up to $\\phi\\approx 0.1$, is considerably more compact at low volume fractions ($\\phi \\leq 0.2$) in monodisperse SC particles than in a medium containing SS particles. A 1:1 mixture of SS and SC crowders induces greater chain compaction than the pure SS or SC crowders at the same $\\phi$ with the effect being highly non-additive. We also discover a counter-intuitive result that polydisperse crowding environment, mimicking the composition of a cell lysate, swells the DNA-like polymer, which is in stark contrast to the size reduction of flexible polymer in the same milieu. Trapping of the stiff chain in a fluctuating tube-like environment created by large-sized crowders explains the dramatic increase in size and persistence length of the stiff chain. In the polydisperse medium, mimicking the cellular environment, the size of the DNA (or related RNA) is determined by $L/l_p$. At low $L/l_p$ the size of the polymer is unaffected whereas there is a dramatic swelling at intermediate value of $L/l_p$. We use these results to provide insights into recent experiments on crowding effects on RNA, and also make testable predictions.

  7. Iron Stores, Hepcidin, and Aortic Stiffness in Individuals with Hypertension

    PubMed Central

    Valenti, Luca; Maloberti, Alessandro; Signorini, Stefano; Milano, Marta; Cesana, Francesca; Cappellini, Fabrizio; Dongiovanni, Paola; Porzio, Marianna; Soriano, Francesco; Brambilla, Maura; Cesana, Giancarlo; Brambilla, Paolo

    2015-01-01

    Background & Aims Iron accumulation within the arterial wall has been hypothesized to promote atherosclerosis progression. Aim of this study was to evaluate whether the hormone hepcidin and iron stores are associated with arterial stiffness in subjects with essential hypertension. Methods Circulating hepcidin, ferritin, and mutations in the hemochromatosis gene were compared between subjects included in the first vs. third tertile (n=284 each) of carotid-femoral pulse wave velocity (PWV) in an unselected cohort of patients with arterial hypertension. Results At univariate logistic regression analysis, high PWV was associated with higher ferritin levels (p=0.010), but lower hepcidin (p=0.045), and hepcidin ferritin/ratio (p<0.001). Hemochromatosis mutations predisposing to iron overload were associated with high PWV (p=0.025). At multivariate logistic regression analysis, high aortic stiffness was associated with older age, male sex, lower BMI, higher systolic blood pressure and heart rate, hyperferritinemia (OR 2.05, 95% c.i. 1.11-3.17 per log ng/ml; p=0.022), and lower circulating hepcidin concentration (OR 0.29, 95% c.i. 0.16-0.51 per log ng/ml; p<0.001). In subgroup analyses, high PWV was associated with indices of target organ damage, including micro-albuminuria (n=125, p=0.038), lower ejection fraction (n=175, p=0.031), cardiac diastolic dysfunction (p=0.004), and lower S wave peak systolic velocity (p<0.001). Ferritin was associated with cardiac diastolic dysfunction, independently of confounders (p=0.006). Conclusions In conclusion, hyperferritinemia is associated with high aortic stiffness and cardiac diastolic dysfunction, while low circulating hepcidin with high aortic stiffness. PMID:26244503

  8. A new strategy for stiffness evaluation of sheet metal parts

    NASA Astrophysics Data System (ADS)

    Cai, Q.; Volk, W.; Düster, A.; Rank, E.

    2011-08-01

    In the automotive industry, surfaces of styling models are shaped very often in physical models. For example, in the styling process of a car body important design work is realized by clay models and the resulting geometry information typically comes from optical scans. The scanned data is given in the form of point clouds which is then utilized in the virtual planning process for engineering work, e.g. to evaluate the load-carrying capacity. This is an important measure for the stiffness of the car body panels. In this contribution, the following two issues are discussed: what is the suitable geometric representation of the stiffness of the car body and how it is computed if only discrete point clouds exist. In the first part, the suitable geometric representation is identified by constructing continuous CAD models with different geometric parameters, e.g. Gaussian curvature and mean curvature. The stiffness of models is then computed in LS-DYNA and the influence of different geometric parameters is presented based on the simulation result. In the second part, the point clouds from scanned data, rather than continuous CAD models, are directly utilized to estimate the Gaussian curvature, which is normally derived from continuous surfaces. The discrete Gauss-Bonnet algorithm is applied to estimate the Gaussian curvature of the point clouds and the sensitivity of the algorithm with respect to the mesh quality is analyzed. In this way, the stiffness evaluation process in an early stage can be accelerated since the transformation from discrete data to continuous CAD data is labor-intensive. The discrete Gauss-Bonnet algorithm is finally applied to a sheet metal model of the BMW 3 series.

  9. Thermomechanical characterization of graphite/polymide composites. [Stiffness; strength; shear properties

    SciTech Connect

    Kunz, S. C.

    1980-01-01

    The stiffness, strength and shear properties of three polyimide resins (NR-150B2, PMR-15 and CPI-2237) combined with three different moduli graphite fibers (C-6000, F-5A and GY-70) were determined at 20 to 371/sup 0/. Stiffness retention with increasing temperature is affected only by the thermal integrity of the polymide matrix. No loss in modulus occurs up to 316/sup 0/C for the PMR-15 and CPI-2237 based composites (T/sub g/ = 377/sup 0/C) or to 260/sup 0/C for the NR-150B2 based material (T/sub g/ approx. = 349/sup 0/C), with any of the three fibers. Both flexure and shear strengths show fiber dependent behavior with temperature. The higher modulus fiber composites (F-5A, GY-70) undergo little strength change up to 343/sup 0/C. Composite strengths of the lower modulus fibers (C-6000), however, degrade by as much as 50% over the same temperature range. Thermal-oxidative stability of the various graphite fibers, and its effect on interfacial strength degradation, are considered primary causes for the fiber-type dominated strength behavior. In general, strength retention appears directly related to degree of graphitization (modulus) of the fibers. The accumulated mechanical property data, some previously unknown, are correlated with microstructural features such as the fiber-matrix adhesion, porosity and processing defects. 11 figures.

  10. Manipulation under Anesthesia for Stiffness after Total Knee Arthroplasty

    PubMed Central

    Yoo, Ju-Hyung; Oh, Jin-Cheol; Park, Sang-Hoon

    2015-01-01

    Purpose This study evaluated the incidence of manipulation under anesthesia (MUA) for stiffness after total knee arthroplasty (TKA) and the degree of joint motion recovery after MUA. Materials and Methods A total of 4,449 TKAs (2,973 patients) were performed between March 2000 and August 2014. Cases that underwent MUA for stiffness after TKA were reviewed. TKAs were performed using the conventional procedure in 329 cases and using the minimally invasive procedure in 4,120 cases. The preoperative range of joint motion, timing of manipulation, diagnosis and the range of joint motion before and after MUA were retrospectively investigated. Results MUA was carried out in 22 cases (16 patients), resulting in the incidence of 0.5%. The incidence after the conventional procedure was 1.2% and 0.4% after the minimally invasive procedure. In the manipulated knees, the preoperative range of motion (ROM) was 102.5°±26.7°, and the preoperative diagnosis was osteoarthritis in 19 cases, rheumatoid arthritis in two, and infection sequela in one. MUA was performed 4.7±3.0 weeks after TKA. The average ROM was 64.5°±13.5° before manipulation. At an average of 64.3±41.3 months after manipulation, the ROM was recovered to 113.4°±31.2°, which was an additional 49.9° improvement in flexion. Conclusions The satisfactory recovery of joint movement was achieved when MUA for stiffness was performed relatively early after TKA. PMID:26676186

  11. Origami tubes assembled into stiff, yet reconfigurable structures and metamaterials.

    PubMed

    Filipov, Evgueni T; Tachi, Tomohiro; Paulino, Glaucio H

    2015-10-01

    Thin sheets have long been known to experience an increase in stiffness when they are bent, buckled, or assembled into smaller interlocking structures. We introduce a unique orientation for coupling rigidly foldable origami tubes in a "zipper" fashion that substantially increases the system stiffness and permits only one flexible deformation mode through which the structure can deploy. The flexible deployment of the tubular structures is permitted by localized bending of the origami along prescribed fold lines. All other deformation modes, such as global bending and twisting of the structural system, are substantially stiffer because the tubular assemblages are overconstrained and the thin sheets become engaged in tension and compression. The zipper-coupled tubes yield an unusually large eigenvalue bandgap that represents the unique difference in stiffness between deformation modes. Furthermore, we couple compatible origami tubes into a variety of cellular assemblages that can enhance mechanical characteristics and geometric versatility, leading to a potential design paradigm for structures and metamaterials that can be deployed, stiffened, and tuned. The enhanced mechanical properties, versatility, and adaptivity of these thin sheet systems can provide practical solutions of varying geometric scales in science and engineering. PMID:26351693

  12. Microtensile measurements of single trabeculae stiffness in human femur.

    PubMed

    Bini, Fabiano; Marinozzi, Andrea; Marinozzi, Franco; Patanè, Federico

    2002-11-01

    In this paper, the authors perform microtensile tests of single trabeculae excised from a human femur head. One of the main issues of this work is to establish some experimental procedures for preparing and testing the specimens. The use of a well-characterized microtensile apparatus allows for a low intraspecimen dispersion of the measured stiffness. Tensile/compressive tests were chosen because they appear less sensitive to errors in the cross-sectional area measurements with respect to bending tests. By these considerations, some tensile/compressive tests of plate-like trabecular specimens have been carried out. Typical stiffness values are 74.2+/-0.7Nmm(-1) for tensile tests, and 58.9+/-0.6Nmm(-1) for compressive test. Another compressive test performed on a shorter specimen yielded a stiffness value of 148.3+/-5.3Nmm(-1). The maximum applied load was about 0.5N. Rough measurements of specimens sizes yielded a Young's modulus value ranging from 1.41 to 1.89GPa. PMID:12413971

  13. Normalized stiffness ratios for mechanical characterization of isotropic acoustic foams.

    PubMed

    Sahraoui, Sohbi; Brouard, Bruno; Benyahia, Lazhar; Parmentier, Damien; Geslain, Alan

    2013-12-01

    This paper presents a method for the mechanical characterization of isotropic foams at low frequency. The objective of this study is to determine the Young's modulus, the Poisson's ratio, and the loss factor of commercially available foam plates. The method is applied on porous samples having square and circular sections. The main idea of this work is to perform quasi-static compression tests of a single foam sample followed by two juxtaposed samples having the same dimensions. The load and displacement measurements lead to a direct extraction of the elastic constants by means of normalized stiffness and normalized stiffness ratio which depend on Poisson's ratio and shape factor. The normalized stiffness is calculated by the finite element method for different Poisson ratios. The no-slip boundary conditions imposed by the loading rigid plates create interfaces with a complex strain distribution. Beforehand, compression tests were performed by means of a standard tensile machine in order to determine the appropriate pre-compression rate for quasi-static tests. PMID:25669274

  14. Arterial Stiffness, Oxidative Stress, and Smoke Exposure in Wildland Firefighters

    PubMed Central

    Gaughan, Denise M.; Siegel, Paul D.; Hughes, Michael D.; Chang, Chiung-Yu; Law, Brandon F.; Campbell, Corey R.; Richards, Jennifer C.; Kales, Stefanos F.; Chertok, Marcia; Kobzik, Lester; Nguyen, Phuongson; O’Donnell, Carl R.; Kiefer, Max; Wagner, Gregory R.; Christiani, David C.

    2015-01-01

    Objectives To assess the association between exposure, oxidative stress, symptoms, and cardiorespiratory function in wildland firefighters. Methods We studied two Interagency Hotshot Crews with questionnaires, pulse wave analysis for arterial stiffness, spirometry, urinary 8-iso-prostaglandin F2? (8-isoprostane) and 8-hydroxy-2?-deoxyguanosine (8-OHdG), and the smoke exposure marker (urinary levoglucosan). Arterial stiffness was assessed by examining levels of the aortic augmentation index, expressed as a percentage. An oxidative stress score comprising the average of z-scores created for 8-OHdG and 8-isoprostane was calculated. Results Mean augmentation index % was higher for participants with higher oxidative stress scores after adjusting for smoking status. Specifically for every one unit increase in oxidative stress score the augmentation index % increased 10.5% (95% CI: 2.5, 18.5%). Higher mean lower respiratory symptom score was associated with lower percent predicted forced expiratory volume in one second/forced vital capacity. Conclusions Biomarkers of oxidative stress may serve as indicators of arterial stiffness in wildland firefighters. PMID:24909863

  15. Active stiffness modulation of fins using macro fiber composites

    NASA Astrophysics Data System (ADS)

    Kancharala, Ashok K.; Philen, Michael K.

    2013-04-01

    Studies on the role of body flexibility in propulsion suggest that fish have the ability to control or modulate the stiffness of the fin for optimized propulsive performance. Fins with certain stiffness might be efficient for a particular set of operating parameters but may be inefficient for other parameters. Therefore active stiffness modulation of a fin can improve the propulsive performance for a range of operating conditions. This paper discusses the preliminary experimental work on the open loop active deformation control of heaving flexible fins using Macro Fiber Composites (MFCs). The effect of important parameters such as oscillation frequency, flexibility of the fin, applied voltage and the phase difference between applied voltage and heaving on propulsive performance are studied and reported. The results indicate that propulsive performance can be improved by active control of the fins. The mean thrust improved by 30- 38% for the fins used in the experiments. The phase difference of ~90° is found to be optimal for maximized propulsive performance for the parameters considered in the study. Furthermore, there exists an optimal voltage magnitude at which the propulsive performance is a maximum for the range of operating conditions.

  16. Explicit Integration of Extremely Stiff Reaction Networks: Asymptotic Methods

    SciTech Connect

    Guidry, Mike W; Budiardja, R.; Feger, E.; Billings, J. J.; Hix, William Raphael; Messer, O.E.B.; Roche, K. J.; McMahon, E.; He, M.

    2013-01-01

    We show that, even for extremely stiff systems, explicit integration may compete in both accuracy and speed with implicit methods if algebraic methods are used to stabilize the numerical integration. The stabilizing algebra differs for systems well removed from equilibrium and those near equilibrium. This paper introduces a quantitative distinction between these two regimes and addresses the former case in depth, presenting explicit asymptotic methods appropriate when the system is extremely stiff but only weakly equilibrated. A second paper [1] examines quasi-steady-state methods as an alternative to asymptotic methods in systems well away from equilibrium and a third paper [2] extends these methods to equilibrium conditions in extremely stiff systems using partial equilibrium methods. All three papers present systematic evidence for timesteps competitive with implicit methods. Because explicit methods can execute a timestep faster than an implicit method, our results imply that algebraically stabilized explicit algorithms may offer a means to integration of larger networks than have been feasible previously in various disciplines.

  17. Extracellular matrix stiffness and composition jointly regulate the induction of malignant phenotypes in mammary epithelium

    NASA Astrophysics Data System (ADS)

    Chaudhuri, Ovijit; Koshy, Sandeep T.; Branco da Cunha, Cristiana; Shin, Jae-Won; Verbeke, Catia S.; Allison, Kimberly H.; Mooney, David J.

    2014-10-01

    In vitro models of normal mammary epithelium have correlated increased extracellular matrix (ECM) stiffness with malignant phenotypes. However, the role of increased stiffness in this transformation remains unclear because of difficulties in controlling ECM stiffness, composition and architecture independently. Here we demonstrate that interpenetrating networks of reconstituted basement membrane matrix and alginate can be used to modulate ECM stiffness independently of composition and architecture. We find that, in normal mammary epithelial cells, increasing ECM stiffness alone induces malignant phenotypes but that the effect is completely abrogated when accompanied by an increase in basement-membrane ligands. We also find that the combination of stiffness and composition is sensed through ?4 integrin, Rac1, and the PI3K pathway, and suggest a mechanism in which an increase in ECM stiffness, without an increase in basement membrane ligands, prevents normal ?6?4 integrin clustering into hemidesmosomes.

  18. Effect of Pressure on Liver Stiffness During the Development of Liver Fibrosis in Rabbits.

    PubMed

    Tang, Wen Bo; Xu, Qing Hua; Jiao, Zi Yu; Wu, Rong; Song, Qing; Luo, Yu Kun

    2016-01-01

    This study was designed to investigate whether hepatic arterial pressure and portal pressure have an effect on liver stiffness during the development of liver fibrosis. Liver fibrosis was induced in 50 healthy New Zealand white rabbits. Laparotomy was performed to measure liver stiffness, and the portal vein and hepatic artery were successively ligated to repeat the measurements. A significant difference was observed among liver stiffness values measured at different time points (F = 22.82, p < 0.001). Differences between original liver stiffness and liver stiffness measured after portal ligation were positively correlated with portal pressure (r = 0.801, p < 0.001). In animals with grade 4 liver fibrosis, the increase in liver stiffness caused by pressure was greater than that caused by extracellular matrix accumulation (p = 0.002). In conclusion, hepatic arterial pressure and portal pressure have a significant effect on liver stiffness during the development of liver fibrosis. PMID:26497767

  19. Binomial coefficient-harmonic sum identities associated to supercongruences

    E-print Network

    McCarthy, Dermot

    2012-01-01

    We establish two binomial coefficient--generalized harmonic sum identities using the partial fraction decomposition method. These identities are a key ingredient in the proofs of numerous supercongruences. In particular, in other works of the author, they are used to establish modulo $p^k$ ($k>1$) congruences between truncated generalized hypergeometric series, and a function which extends Greene's hypergeometric function over finite fields to the $p$-adic setting. A specialization of one of these congruences is used to prove an outstanding conjecture of Rodriguez-Villegas which relates a truncated generalized hypergeometric series to the $p$-th Fourier coefficient of a particular modular form.

  20. A new correlation coefficient for bivariate time-series data

    NASA Astrophysics Data System (ADS)

    Erdem, Orhan; Ceyhan, Elvan; Varli, Yusuf

    2014-11-01

    The correlation in time series has received considerable attention in the literature. Its use has attained an important role in the social sciences and finance. For example, pair trading in finance is concerned with the correlation between stock prices, returns, etc. In general, Pearson’s correlation coefficient is employed in these areas although it has many underlying assumptions which restrict its use. Here, we introduce a new correlation coefficient which takes into account the lag difference of data points. We investigate the properties of this new correlation coefficient. We demonstrate that it is more appropriate for showing the direction of the covariation of the two variables over time. We also compare the performance of the new correlation coefficient with Pearson’s correlation coefficient and Detrended Cross-Correlation Analysis (DCCA) via simulated examples.

  1. Direct Extraction of One-loop Integral Coefficients

    SciTech Connect

    Forde, Darren

    2007-04-16

    We present a general procedure for obtaining the coefficients of the scalar bubble and triangle integral functions of one-loop amplitudes. Coefficients are extracted by considering two-particle and triple unitarity cuts of the corresponding bubble and triangle integral functions. After choosing a specific parameterization of the cut loop momentum we can uniquely identify the coefficients of the desired integral functions simply by examining the behavior of the cut integrand as the unconstrained parameters of the cut loop momentum approach infinity. In this way we can produce compact forms for scalar integral coefficients. Applications of this method are presented for both QCD and electroweak processes, including an alternative form for the recently computed three-mass triangle coefficient in the six-photon amplitude A{sub 6}(1{sup -}, 2{sup +}, 3{sup -}, 4{sup +}, 5{sup -}, 6{sup +}). The direct nature of this extraction procedure allows for a very straightforward automation of the procedure.

  2. Scaling of Fluid Flow and Seismic Stiffness of Fractures

    NASA Astrophysics Data System (ADS)

    Petrovitch, C.; Nolte, D.; Pyrak-Nolte, L. J.

    2011-12-01

    A firm understanding of the relationship between the hydraulic and mechanical properties of fractures has been long sought. Seismic techniques probe the mechanical properties of fractures, e.g. fracture specific stiffness. Providing a connection between fluid flow and fracture stiffness would enable remote estimation of the flow properties in the subsurface. Linking theses two properties would improve society's ability to assess the risk related to the extraction of drinkable water, oil production, and the storage of CO2 in subsurface reservoirs. This relationship is complicated because the subsurface is composed of a hierarchy of structures and processes that span a large range of length and time scales. A scaling approach enables researchers to translate laboratory measurements towards the field scale and vise a versa. We performed a computational study of the scaling of the flow-stiffness relationship for planar fractures with uncorrelated aperture distributions. Three numerical models were required to study the scaling properties of the flow-stiffness relationship for single fractures. Firstly, the fracture topologies where constructed using a stratified continuum percolation method. Only uncorrelated fracture geometries were considered to provide a baseline of understanding for the different interacting critical thresholds occurring in the hydraulic and mechanical properties. Secondly, fracture stiffness was calculated by modeling the deformation of asperities and a deformable half space. This model computed the displacement-stress curves for a given fracture, from which the stiffness was extracted. Thirdly, due to the sensitive nature of the critical phenomena associated with fluid flow through fractures, two network flow models were used for verification. The fractures were first modeled as a network of elliptical pipes and the corresponding linear system of equations was solved. The second method consisted of using a lattice grid network, where the flow is computed using the "cubic law." Fractures were generated at five sizes (1, 0.5, 0.25, 0.125, and 0.0625m) to provide an order of magnitude variation. Each fracture was constructed such that the contact area ranged from approximately 5% to 30%. The rocks were given the properties of granite and stressed to a maximum load of 70MPa. The deformation solver was given 50 steps to reach the final load so that its flow rate could be monitored during each loading step. The results clearly showed a dependence on scale. Under low loads flow-stiffness was in an effective medium regime. However as the load increased, a distinct scale dependence emerged. This occurs because as the load increases there is an overall increase in contact area, which in turn moves the flow dynamics into a critical regime. From this finite size scaling effect, we analyzed how the uncorrelated topologies length scales changed under load to compute the flow exponents for the system. Acknowledgments: Geosciences Research Program, Office of Basic Energy Sciences US Department of Energy (DE-FG02-09ER16022), the Geo-mathematical Imaging Group at Purdue University, and the Purdue Research Foundation.

  3. Risk assessment of distribution coefficient from 137Cs measurements.

    PubMed

    Külahci, Fatih; Sen, Zekai

    2009-02-01

    Classically distribution coefficient is defined as the ratio of solid total element concentration to surface water total concentration. This coefficient is obtained from the ion measurements in the Keban Dam, Turkey, which supplies water for domestic, irrigation and hydroelectric energy generation purposes. The measurements of 137Cs are carried out in 40 different sites and the general risk formulation and application is achieved for the distribution coefficient. The models are of exponential type and the spatial independence of the data is considered. Various charts are prepared for a set of risk levels as 5%, 10%, 20%, 25%, and 50%. PMID:18274870

  4. Collective friction coefficients in the relaxation time approximation F. A. Ivanyuk

    E-print Network

    Pomorski, Krzysztof

    Collective friction coefficients in the relaxation time approximation F. A. Ivanyuk Institute components of the friction coefficient for various single-particle potentials and have found that the nondiagonal component of the friction coefficient depends generally on the diffuseness of the potential

  5. Theory and measurements of labyrinth seal coefficients for rotor stability of turbocompressors

    NASA Technical Reports Server (NTRS)

    Syssmann, H. R.

    1987-01-01

    The prediction of rotordynamic coefficients for gas seals is achieved with the aid of a two-volume bulk flow model based on turbulent rotationally symmetric 3D flow calculations including swirl flow. Comparison of cross-coupling and damping coefficients with measurements confirm this approach. In particular the theoretically predicted phenomenon that labyrinth damping is retained without inlet swirl is confirmed. This is important for the design of high pressure compressors, where labyrinth damping is a major contribution improving rotor stability. Discrepancies are found when comparing theory with measured direct stiffness and the cross-coupling damping coefficients. First measurements of labyrinth seals on a recently installed test rig operated with water are presented. Since forces are larger than on test stands operated with air and since individual chamber forces are obtained phenomena like inlet effects may be studied.

  6. Conversion coefficients for superheavy elements

    E-print Network

    T. Kibédi; M. B. Trzhaskovskaya; M. Gupta; A. E. Stuchbery

    2011-03-10

    In this paper we report on internal conversion coefficients for Z = 111 to Z = 126 superheavy elements obtained from relativistic Dirac-Fock (DF) calculations. The effect of the atomic vacancy created during the conversion process has been taken into account using the so called "Frozen Orbital" approximation. The selection of this atomic model is supported by our recent comparison of experimental and theoretical conversion coefficients across a wide range of nuclei. The atomic masses, valence shell electron configurations, and theoretical atomic binding energies required for the calculations were adopted from a critical evaluation of the published data. The new conversion coefficient data tables presented here cover all atomic shells, transition energies from 1 keV up to 6000 keV, and multipole orders of 1 to 5. A similar approach was used in our previous calculations [1] for Z = 5 - 110.

  7. Derivatives of buckling loads and vibration frequencies with respect to stiffness and initial strain parameters

    NASA Technical Reports Server (NTRS)

    Haftka, Raphael T.; Cohen, Gerald A.; Mroz, Zenon

    1990-01-01

    A uniform variational approach to sensitivity analysis of vibration frequencies and bifurcation loads of nonlinear structures is developed. Two methods of calculating the sensitivities of bifurcation buckling loads and vibration frequencies of nonlinear structures, with respect to stiffness and initial strain parameters, are presented. A direct method requires calculation of derivatives of the prebuckling state with respect to these parameters. An adjoint method bypasses the need for these derivatives by using instead the strain field associated with the second-order postbuckling state. An operator notation is used and the derivation is based on the principle of virtual work. The derivative computations are easily implemented in structural analysis programs. This is demonstrated by examples using a general purpose, finite element program and a shell-of-revolution program.

  8. Mathematical model of micropolar elastic thin plates and their strength and stiffness characteristics

    NASA Astrophysics Data System (ADS)

    Sarkisyan, S. O.

    2012-03-01

    A number of hypotheses were formulated using the properties of an asymptotic solution of boundary-value problems of the three-dimensional micropolar (moment asymmetric) theory of elasticity for areas with one geometrical parameter being substantially smaller than the other two (plates and shells). A general theory of bending deformation of micropolar elastic thin plates with independent fields of displacements and rotations is constructed. In the constructed model of a micropolar elastic plate, transverse shear strains are fully taken into account. A problem of determining the stress-strain state in bending deformation of micropolar elastic thin rectangular plates is considered. The numerical analysis reveals that plates made of a micropolar elastic material have high strength and stiffness characteristics.

  9. Seebeck coefficient of one electron

    SciTech Connect

    Durrani, Zahid A. K.

    2014-03-07

    The Seebeck coefficient of one electron, driven thermally into a semiconductor single-electron box, is investigated theoretically. With a finite temperature difference ?T between the source and charging island, a single electron can charge the island in equilibrium, directly generating a Seebeck effect. Seebeck coefficients for small and finite ?T are calculated and a thermally driven Coulomb staircase is predicted. Single-electron Seebeck oscillations occur with increasing ?T, as one electron at a time charges the box. A method is proposed for experimental verification of these effects.

  10. Biomechanical model of the human cornea: considering shear stiffness and regional variation of collagen anisotropy and density.

    PubMed

    Whitford, Charles; Studer, Harald; Boote, Craig; Meek, Keith M; Elsheikh, Ahmed

    2015-02-01

    A numerical model based on continuum mechanics theory has been developed which represents the 3D anisotropic behaviour of the corneal stroma. Experimental data has been gathered from a number of previous studies to provide the basis and calibration parameters for the numerical modelling. The resulting model introduces numerical representation of collagen fibril density and its related regional variation, interlamellar cohesion and age-related stiffening in an anisotropic model of the human cornea. Further, the model incorporates previous modelling developments including representation of lamellae anisotropy and stiffness of the underlying matrix. Wide angle X-ray scattering has provided measured data which quantifies relative fibril anisotropy in the 2D domain. Accurate numerical description of material response to deformation is essential to providing representative simulations of corneal behaviour. Representing experimentally obtained 2D anisotropy and regional density variation in the 3D domain is an essential component of this accuracy. The constitutive model was incorporated into finite element analysis. Combining with inverse analysis, the model was calibrated to an extensive experimental database of ex vivo corneal inflation tests and ex vivo corneal shear tests. This model represents stiffness of the underlying matrix which is 2-3 orders of magnitude than the mechanical response representing the collagen fibrils in the lamellae. The presented model, along with its age dependent material coefficients, allows finite element modelling for an individual patient with material stiffness approximated based on their age. This has great potential to be used in both daily clinical practice for the planning and optimisation of corrective procedures and in pre-clinical optimisation of diagnostic procedures. PMID:25460928

  11. Multi-fingered haptic palpation utilizing granular jamming stiffness feedback actuators

    NASA Astrophysics Data System (ADS)

    Li, Min; Ranzani, Tommaso; Sareh, Sina; Seneviratne, Lakmal D.; Dasgupta, Prokar; Wurdemann, Helge A.; Althoefer, Kaspar

    2014-09-01

    This paper describes a multi-fingered haptic palpation method using stiffness feedback actuators for simulating tissue palpation procedures in traditional and in robot-assisted minimally invasive surgery. Soft tissue stiffness is simulated by changing the stiffness property of the actuator during palpation. For the first time, granular jamming and pneumatic air actuation are combined to realize stiffness modulation. The stiffness feedback actuator is validated by stiffness measurements in indentation tests and through stiffness discrimination based on a user study. According to the indentation test results, the introduction of a pneumatic chamber to granular jamming can amplify the stiffness variation range and reduce hysteresis of the actuator. The advantage of multi-fingered palpation using the proposed actuators is proven by the comparison of the results of the stiffness discrimination performance using two-fingered (sensitivity: 82.2%, specificity: 88.9%, positive predicative value: 80.0%, accuracy: 85.4%, time: 4.84 s) and single-fingered (sensitivity: 76.4%, specificity: 85.7%, positive predicative value: 75.3%, accuracy: 81.8%, time: 7.48 s) stiffness feedback.

  12. Material Stiffness Effects on Neurite Alignment to Photopolymerized Micropatterns

    PubMed Central

    2015-01-01

    The ability to direct neurite growth into a close proximity of stimulating elements of a neural prosthesis, such as a retinal or cochlear implant (CI), may enhance device performance and overcome current spatial signal resolution barriers. In this work, spiral ganglion neurons (SGNs), which are the target neurons to be stimulated by CIs, were cultured on photopolymerized micropatterns with varied matrix stiffnesses to determine the effect of rigidity on neurite alignment to physical cues. Micropatterns were generated on methacrylate thin film surfaces in a simple, rapid photopolymerization step by photomasking the prepolymer formulation with parallel line–space gratings. Two methacrylate series, a nonpolar HMA-co-HDDMA series and a polar PEGDMA-co-EGDMA series, with significantly different surface wetting properties were evaluated. Equivalent pattern periodicity was maintained across each methacrylate series based on photomask band spacing, and the feature amplitude was tuned to a depth of 2 ?m amplitude for all compositions using the temporal control afforded by the UV curing methodology. The surface morphology was characterized by scanning electron microscopy and white light interferometry. All micropatterned films adsorb similar amounts of laminin from solution, and no significant difference in SGN survival was observed when the substrate compositions were compared. SGN neurite alignment significantly increases with increasing material modulus for both methacrylate series. Interestingly, SGN neurites respond to material stiffness cues that are orders of magnitude higher (GPa) than what is typically ascribed to neural environments (kPa). The ability to understand neurite response to engineered physical cues and mechanical properties such as matrix stiffness will allow the development of advanced biomaterials that direct de novo neurite growth to address the spatial signal resolution limitations of current neural prosthetics. PMID:25211120

  13. Material stiffness effects on neurite alignment to photopolymerized micropatterns.

    PubMed

    Tuft, Bradley W; Zhang, Lichun; Xu, Linjing; Hangartner, Austin; Leigh, Braden; Hansen, Marlan R; Guymon, C Allan

    2014-10-13

    The ability to direct neurite growth into a close proximity of stimulating elements of a neural prosthesis, such as a retinal or cochlear implant (CI), may enhance device performance and overcome current spatial signal resolution barriers. In this work, spiral ganglion neurons (SGNs), which are the target neurons to be stimulated by CIs, were cultured on photopolymerized micropatterns with varied matrix stiffnesses to determine the effect of rigidity on neurite alignment to physical cues. Micropatterns were generated on methacrylate thin film surfaces in a simple, rapid photopolymerization step by photomasking the prepolymer formulation with parallel line-space gratings. Two methacrylate series, a nonpolar HMA-co-HDDMA series and a polar PEGDMA-co-EGDMA series, with significantly different surface wetting properties were evaluated. Equivalent pattern periodicity was maintained across each methacrylate series based on photomask band spacing, and the feature amplitude was tuned to a depth of 2 ?m amplitude for all compositions using the temporal control afforded by the UV curing methodology. The surface morphology was characterized by scanning electron microscopy and white light interferometry. All micropatterned films adsorb similar amounts of laminin from solution, and no significant difference in SGN survival was observed when the substrate compositions were compared. SGN neurite alignment significantly increases with increasing material modulus for both methacrylate series. Interestingly, SGN neurites respond to material stiffness cues that are orders of magnitude higher (GPa) than what is typically ascribed to neural environments (kPa). The ability to understand neurite response to engineered physical cues and mechanical properties such as matrix stiffness will allow the development of advanced biomaterials that direct de novo neurite growth to address the spatial signal resolution limitations of current neural prosthetics. PMID:25211120

  14. Vitamin E reduces liver stiffness in nonalcoholic fatty liver disease

    PubMed Central

    Fukui, Aiko; Kawabe, Naoto; Hashimoto, Senju; Murao, Michihito; Nakano, Takuji; Shimazaki, Hiroaki; Kan, Toshiki; Nakaoka, Kazunori; Ohki, Masashi; Takagawa, Yuka; Takamura, Tomoki; Kamei, Hiroyuki; Yoshioka, Kentaro

    2015-01-01

    AIM: To evaluate the efficacy of vitamin E treatment on liver stiffness in nonalcoholic fatty liver disease (NAFLD). METHODS: Thirty-eight NAFLD patients were administered vitamin E for > 1 year. The doses of vitamin E were 150, 300, or 600 mg; three times per day after each meal. Responses were assessed by liver enzyme levels [aspartate aminotransferase (AST), alanine aminotranferease (ALT), and ?-glutamyl transpeptidase (?-GTP)], noninvasive scoring systems of hepatic fibrosis-4 [FIB-4 index and aspartate aminotransferase-to-platelet index (APRI)], and liver stiffness [velocity of shear wave (Vs)] measured by acoustic radiation force impulse elastography. Vs measurements were performed at baseline and 12 mo after baseline. The patients were genotyped for the patatin-like phospholipase domain containing 3 (PNPLA3) polymorphisms and then divided into either the CC/CG or GG group to examine each group’s responses to vitamin E treatment. RESULTS: We found marked differences in the platelet count, serum albumin levels, alkaline phosphatase levels, FIB-4 index, APRI, and Vs at baseline depending on the PNPLA3 polymorphism. AST, ALT, and ?-GTP levels (all P < 0.001); FIB-4 index (P = 0.035); APRI (P < 0.001); and Vs (P < 0.001) significantly decreased from baseline to 12 mo in the analysis of all patients. In the subset analyses of PNPLA3 genotypes, AST levels (P = 0.011), ALT levels (P < 0.001), ?-GTP levels (P = 0.005), APRI (P = 0.036), and Vs (P = 0.029) in genotype GG patients significantly improved, and AST and ALT levels (both P < 0.001), ?-GTP levels (P = 0.003), FIB-4 index (P = 0.017), and APRI (P < 0.001) in genotype CC/CG patients. CONCLUSION: One year of vitamin E treatment improved noninvasive fibrosis scores and liver stiffness in NAFLD patients. The responses were similar between different PNPLA3 genotypes. PMID:26644818

  15. Kinematic Characterization of Left Ventricular Chamber Stiffness and Relaxation

    NASA Astrophysics Data System (ADS)

    Mossahebi, Sina

    Heart failure is the most common cause of hospitalization today, and diastolic heart failure accounts for 40-50% of cases. Therefore, it is critical to identify diastolic dysfunction at a subclinical stage so that appropriate therapy can be administered before ventricular function is further, and perhaps irreversibly impaired. Basic concepts in physics such as kinematic modeling provide a unique method with which to characterize cardiovascular physiology, specifically diastolic function (DF). The advantage of an approach that is standard in physics, such as the kinematic modeling is its causal formulation that functions in contrast to correlative approaches traditionally utilized in the life sciences. Our research group has pioneered theoretical and experimental quantitative analysis of DF in humans, using both non-invasive (echocardiography, cardiac MRI) and invasive (simultaneous catheterization-echocardiography) methods. Our group developed and validated the Parametrized Diastolic Filling (PDF) formalism which is motivated by basic physiologic principles (LV is a mechanical suction pump at the mitral valve opening) that obey Newton's Laws. PDF formalism is a kinematic model of filling employing an equation of motion, the solution of which accurately predicts all E-wave contours in accordance with the rules of damped harmonic oscillatory motion. The equation's lumped parameters---ventricular stiffness, ventricular viscoelasticity/relaxation and ventricular load---are obtained by solving the 'inverse problem'. The parameters' physiologic significance and clinical utility have been repeatedly demonstrated in multiple clinical settings. In this work we apply our kinematic modeling approach to better understand how the heart works as it fills in order to advance the relationship between physiology and mathematical modeling. Through the use of this modeling, we thereby define and validate novel, causal indexes of diastolic function such as early rapid filling energy, diastatic stiffness, and relaxation and stiffness components of E-wave deceleration time.

  16. Photoinduced variable stiffness of spiropyran-based composites

    SciTech Connect

    Samoylova, E.; Ceseracciu, L.; Allione, M.; Diaspro, A.; Barone, A. C.; Athanassiou, A.

    2011-11-14

    A quantitative demonstration of reversible stiffness upon appropriate light stimulus in a spiropyran-polymeric composite is presented. The polymeric films containing 3% wt. of the photochromic spiropyran were irradiated with alternating ultraviolet and visible light and the storage modulus was measured. A reversible change in modulus of about 7% was observed. The modulus change was attributed to an interaction of the polar merocyanine with the polymeric chains and/or to a variation of effective free volume induced by merocyanine aggregates formed in the polymer upon ultraviolet irradiation. The effect is fully reversed when the merocyanine isomers turn back to the spiropyran state after visible irradiation.

  17. On modeling hydraulic fracture in proper variables: stiffness, accuracy, sensitivity

    E-print Network

    Mishuris, Gennady; Linkov, Alexander

    2012-01-01

    The problem of hydraulic fracture propagation is considered by using its recently suggested modified formulation in terms of the particle velocity, the opening in the proper degree, appropriate spatial coordinates and $\\varepsilon$-regularization. We show that the formulation may serve for significant increasing the efficiency of numerical tracing the fracture propagation. Its advantages are illustrated by re-visiting the Nordgren problem. It is shown that the modified formulation facilitates (i) possibility to have various stiffness of differential equations resulting after spatial discretization, (ii) obtaining highly accurate and stable numerical results with moderate computational effort, and (iii) sensitivity analysis. The exposition is extensively illustrated by numerical examples.

  18. Material selection for acoustic radiators that are light and stiff.

    PubMed

    Porter, S P; Markley, D C; Van Tol, D J; Meyer, R J

    2011-01-01

    The headmass is a key element in tonpilz transducer design. As an acoustic radiator, a successful headmass must be built from a material that is both light and stiff. To assess the suitability of ceramics for this application, the authors used the mechanical properties of candidate materials to perform a theoretical comparison based on the flexural behavior of square plates. Although not a comprehensive metric for identifying the best headmass materials, the headmass flexure may be usefully employed as a first-level selection criteria. A software routine based on thin plate and thick plate theory was created to evaluate the flexural behavior in candidate materials. PMID:21302996

  19. Arterial stiffness in adult patients after Fontan procedure

    PubMed Central

    2014-01-01

    Objectives Increased arterial stiffness is a risk factor of atherosclerosis and cardio-vascular complications. The aim of the study was to determine whether peripheral vascular function might be an early marker of impaired health status in patients with a single ventricle after Fontan procedure. Methods and results Twenty five consecutive adults (11 women and 14 men) aged 24.7?±?6.2 years after the Fontan procedure and 25 sex, age and BMI match healthy volunteers underwent physical examination, blood analysis, transthoracic echocardiography and noninvasive assessment of aortic stiffness. Augmented pressure and Augmentation Index (AIx) were both significantly elevated in Fontan when compared to the controls (6,08?±?0,7 vs. 2,0?±?3,7; p?=?0.002 and 17,01?±?3,3 vs. 6,05?±?11; p?stiffness assessed by a noninvasive technique. Low arterial oxygen saturation postoperative time, age at surgery, white blood cells, TNF? and bilirubin level are associated with arterial stiffening in these patients. The combination of blood parameters of the hepatic function and noninvasive measurements of arterial stiffness could be helpful in comprehensive care of patients with Fontan circulation. PMID:24716671

  20. Elastomeric substrates with embedded stiff platforms for stretchable electronics

    NASA Astrophysics Data System (ADS)

    Romeo, Alessia; Liu, Qihan; Suo, Zhigang; Lacour, Stéphanie P.

    2013-04-01

    Stretchable electronics typically integrate hard, functional materials on soft substrates. Here we report on engineered elastomeric substrates designed to host stretchable circuitry. Regions of a stiff material, patterned using photolithography, are embedded within a soft elastomer leaving a smooth surface. We present the associated design rules to produce stretchable circuits based on experimental as well as modeling data. We demonstrate our approach with thin-film electronic materials. The "customized" elastomeric substrates may also be used as a generic elastic substrate for stretchable circuits prepared with alternative technologies, such as transfer-printing of inorganic, thinned devices.

  1. Binomial Coefficients and Pascal's triangle

    E-print Network

    Papalaskari, Mary-Angela

    Binomial Coefficients and Pascal's triangle CSC 1300 ­ Discrete Structures Papalaskari #12;9 Pascal's Triangle · Pascal's Triangle represents the idenCty: C(n+1,k + 3xy2 + y3 · Binomial Theorem (x+y)n = C

  2. Prediction of stream volatilization coefficients

    USGS Publications Warehouse

    Rathbun, Ronald E.

    1990-01-01

    Equations are developed for predicting the liquid-film and gas-film reference-substance parameters for quantifying volatilization of organic solutes from streams. Molecular weight and molecular-diffusion coefficients of the solute are used as correlating parameters. Equations for predicting molecular-diffusion coefficients of organic solutes in water and air are developed, with molecular weight and molal volume as parameters. Mean absolute errors of prediction for diffusion coefficients in water are 9.97% for the molecular-weight equation, 6.45% for the molal-volume equation. The mean absolute error for the diffusion coefficient in air is 5.79% for the molal-volume equation. Molecular weight is not a satisfactory correlating parameter for diffusion in air because two equations are necessary to describe the values in the data set. The best predictive equation for the liquid-film reference-substance parameter has a mean absolute error of 5.74%, with molal volume as the correlating parameter. The best equation for the gas-film parameter has a mean absolute error of 7.80%, with molecular weight as the correlating parameter.

  3. Tables of the coefficients A

    NASA Technical Reports Server (NTRS)

    Chandra, N.

    1974-01-01

    Numerical coefficients required to express the angular distribution for the rotationally elastic or inelastic scattering of electrons from a diatomic molecule were tabulated for the case of nitrogen and in the energy range from 0.20 eV to 10.0 eV. Five different rotational states are considered.

  4. Effects of in-plane stiffness and charge transfer on thermal expansion of monolayer transition metal dichalcogenide

    NASA Astrophysics Data System (ADS)

    Wang, Zhan-Yu; Zhou, Yan-Li; Wang, Xue-Qing; Wang, Fei; Sun, Qiang; Guo, Zheng-Xiao; Jia, Yu

    2015-02-01

    The temperature dependence of lattice constants is studied by using first-principles calculations to determine the effects of in-plane stiffness and charge transfer on the thermal expansions of monolayer semiconducting transition metal dichalcogenides. Unlike the corresponding bulk material, our simulations show that monolayer MX2 (M = Mo and W; X = S, Se, and Te) exhibits a negative thermal expansion at low temperatures, induced by the bending modes. The transition from contraction to expansion at higher temperatures is observed. Interestingly, the thermal expansion can be tailored regularly by alteration of the M or X atom. Detailed analysis shows that the positive thermal expansion coefficient is determined mainly by the in-plane stiffness, which can be expressed by a simple relationship. Essentially the regularity of this change can be attributed to the difference in charge transfer between the different elements. These findings should be applicable to other two-dimensional systems. Project supported by the National Natural Science Foundation of China (Grant Nos. 11274280 and 11104254) and the National Basic Research Program of China (Grant No. 2012CB921300).

  5. A Comparison of Total and Intrinsic Muscle Stiffness Among Flexors and Extensors of the Ankle, Knee and Elbow

    NASA Technical Reports Server (NTRS)

    Lemoine, Sandra M.

    1997-01-01

    This study examined 3 methods that assessed muscle stiffness. Muscle stiffness has been quantified by tissue reactive force (transverse stiffness), vibration, and force (or torque) over displacement. Muscle stiffness also has two components: reflex (due to muscle sensor activity) and intrinsic (tonic firing of motor units, elastic nature of actin and myosin cross bridges, and connective tissue). This study compared three methods of measuring muscle stiffness of agonist-antagonist muscle pairs of the ankle, knee and elbow.

  6. Experimental determination of the complex stiffness tensor and Euler angles in anisotropic media using ultrasonic waves

    SciTech Connect

    Alaoui-Ismaili, N.; Guy, P.; Chassignole, B.

    2014-02-18

    The aim of this work is to measure the complex elastic tensor and Euler angles in very complex anisotropic media like austenitic steel welds, by inverse problem resolution from experimental data. The obtained experimental characteristics of the anisotropic material will be injected in a FE code developed by EDF enabling the simulation of an actual ultrasonic NDE of welds. The present work aims to provide reliable input data to the 3D future development of the code. In particular, this complex elastic tensor will allow to predict by modeling beam skewing ant attenuation in an austenitic weld. The investigation of such anisotropic media is very complex because of the directional dependency of the elastic stiffness tensor. Then we will discuss the use of a hybrid genetic algorithm to overcome this difficulty. The identification method is based on waveforms spectra reconstruction associated to a physical model describing wave propagation in plates, during underwater measurements. The entire procedure is qualified and validated using simulated data. Moreover, a comparison of the estimated elastic coefficients with literature values and ultrasonic measurements obtained in transmission is also given, at the end of the paper.

  7. Love waves in functionally graded piezoelectric materials by stiffness matrix method.

    PubMed

    Ben Salah, Issam; Wali, Yassine; Ben Ghozlen, Mohamed Hédi

    2011-04-01

    A numerical matrix method relative to the propagation of ultrasonic guided waves in functionally graded piezoelectric heterostructure is given in order to make a comparative study with the respective performances of analytical methods proposed in literature. The preliminary obtained results show a good agreement, however numerical approach has the advantage of conceptual simplicity and flexibility brought about by the stiffness matrix method. The propagation behaviour of Love waves in a functionally graded piezoelectric material (FGPM) is investigated in this article. It involves a thin FGPM layer bonded perfectly to an elastic substrate. The inhomogeneous FGPM heterostructure has been stratified along the depth direction, hence each state can be considered as homogeneous and the ordinary differential equation method is applied. The obtained solutions are used to study the effect of an exponential gradient applied to physical properties. Such numerical approach allows applying different gradient variation for mechanical and electrical properties. For this case, the obtained results reveal opposite effects. The dispersive curves and phase velocities of the Love wave propagation in the layered piezoelectric film are obtained for electrical open and short cases on the free surface, respectively. The effect of gradient coefficients on coupled electromechanical factor, on the stress fields, the electrical potential and the mechanical displacement are discussed, respectively. Illustration is achieved on the well known heterostructure PZT-5H/SiO(2), the obtained results are especially useful in the design of high-performance acoustic surface devices and accurately prediction of the Love wave propagation behaviour. PMID:21035829

  8. A comparison of experimental and theoretical results for leakage, pressure gradients, and rotordynamic coefficients for tapered annular gas seal

    NASA Technical Reports Server (NTRS)

    Elrod, D. A.; Childs, D. W.

    1986-01-01

    A brief review of current annular seal theory and a discussion of the predicted effect on stiffness of tapering the seal stator are presented. An outline of Nelson's analytical-computational method for determining rotordynamic coefficients for annular compressible-flow seals is included. Modifications to increase the maximum rotor speed of an existing air-seal test apparatus at Texas A&M University are described. Experimental results, including leakage, entrance-loss coefficients, pressure distributions, and normalized rotordynamic coefficients, are presented for four convergent-tapered, smooth-rotor, smooth-stator seals. A comparison of the test results shows that an inlet-to-exit clearance ratio of 1.5 to 2.0 provides the maximum direct stiffness, a clearance ratio of 2.5 provides the greatest stability, and a clearance ratio of 1.0 provides the least stability. The experimental results are compared to theoretical results from Nelson's analysis with good agreement. Test results for cross-coupled stiffness show less sensitivity of fluid prerotation than predicted.

  9. Accurate spring constant calibration for very stiff atomic force microscopy cantilevers

    SciTech Connect

    Grutzik, Scott J.; Zehnder, Alan T.; Gates, Richard S.; Gerbig, Yvonne B.; Smith, Douglas T.; Cook, Robert F.

    2013-11-15

    There are many atomic force microscopy (AFM) applications that rely on quantifying the force between the AFM cantilever tip and the sample. The AFM does not explicitly measure force, however, so in such cases knowledge of the cantilever stiffness is required. In most cases, the forces of interest are very small, thus compliant cantilevers are used. A number of methods have been developed that are well suited to measuring low stiffness values. However, in some cases a cantilever with much greater stiffness is required. Thus, a direct, traceable method for calibrating very stiff (approximately 200 N/m) cantilevers is presented here. The method uses an instrumented and calibrated nanoindenter to determine the stiffness of a reference cantilever. This reference cantilever is then used to measure the stiffness of a number of AFM test cantilevers. This method is shown to have much smaller uncertainty than previously proposed methods. An example application to fracture testing of nanoscale silicon beam specimens is included.

  10. Mechanosensitive Kinases Regulate Stiffness-Induced Cardiomyocyte Maturation

    PubMed Central

    Young, Jennifer L.; Kretchmer, Kyle; Ondeck, Matthew G.; Zambon, Alexander C.; Engler, Adam J.

    2014-01-01

    Cells secrete and assemble extracellular matrix throughout development, giving rise to time-dependent, tissue-specific stiffness. Mimicking myocardial matrix stiffening, i.e. ~10-fold increase over 1 week, with a hydrogel system enhances myofibrillar organization of embryonic cardiomyocytes compared to static hydrogels, and thus we sought to identify specific mechanosensitive proteins involved. Expression and/or phosphorylation state of 309 unique protein kinases were examined in embryonic cardiomyocytes plated on either dynamically stiffening or static mature myocardial stiffness hydrogels. Gene ontology analysis of these kinases identified cardiogenic pathways that exhibited time-dependent up-regulation on dynamic versus static matrices, including PI3K/AKT and p38 MAPK, while GSK3?, a known antagonist of cardiomyocyte maturation, was down-regulated. Additionally, inhibiting GSK3? on static matrices improved spontaneous contraction and myofibril organization, while inhibiting agonist AKT on dynamic matrices reduced myofibril organization and spontaneous contraction, confirming its role in mechanically-driven maturation. Together, these data indicate that mechanically-driven maturation is at least partially achieved via active mechanosensing at focal adhesions, affecting expression and phosphorylation of a variety of protein kinases important to cardiomyogenesis. PMID:25236849

  11. Influence of Polyelectrolyte Film Stiffness on Bacterial Growth

    PubMed Central

    Saha, Naresh; Monge, Claire; Dulong, Virginie; Picart, Catherine; Glinel, Karine

    2015-01-01

    Photo-crosslinkable polyelectrolyte films whose nanomechanical properties can be varied under UV light illumination, were prepared from poly(L-lysine) (PLL) and a hyaluronan derivative modified with photoreactive vinylbenzyl groups (HAVB). The adhesion and the growth of two model bacteria, namely Escherichia coli and Lactococcus lactis, were studied on non-crosslinked and crosslinked films to investigate how the film stiffness influences the bacterial behavior. While the Gram positive L. lactis was shown to grow slowly on both films, independently of their rigidity, the Gram negative E. coli exhibited a more rapid growth on non-crosslinked softer films compared to the stiffer ones. Experiments performed on photo-patterned films showing both soft and stiff regions, confirmed a faster development of E. coli colonies on softer regions. Interestingly, this behavior is opposite to the one reported before for mammalian cells. Therefore, the photo-crosslinked (PLL/HAVB) films are interesting coatings for tissue engineering since they promote the growth of mammalian cells while limiting the bacterial colonization. PMID:23289403

  12. Functional bacterial amyloid increases Pseudomonas biofilm hydrophobicity and stiffness

    PubMed Central

    Zeng, Guanghong; Vad, Brian S.; Dueholm, Morten S.; Christiansen, Gunna; Nilsson, Martin; Tolker-Nielsen, Tim; Nielsen, Per H.; Meyer, Rikke L.; Otzen, Daniel E.

    2015-01-01

    The success of Pseudomonas species as opportunistic pathogens derives in great part from their ability to form stable biofilms that offer protection against chemical and mechanical attack. The extracellular matrix of biofilms contains numerous biomolecules, and it has recently been discovered that in Pseudomonas one of the components includes ?-sheet rich amyloid fibrils (functional amyloid) produced by the fap operon. However, the role of the functional amyloid within the biofilm has not yet been investigated in detail. Here we investigate how the fap-based amyloid produced by Pseudomonas affects biofilm hydrophobicity and mechanical properties. Using atomic force microscopy imaging and force spectroscopy, we show that the amyloid renders individual cells more resistant to drying and alters their interactions with hydrophobic probes. Importantly, amyloid makes Pseudomonas more hydrophobic and increases biofilm stiffness 20-fold. Deletion of any one of the individual members of in the fap operon (except the putative chaperone FapA) abolishes this ability to increase biofilm stiffness and correlates with the loss of amyloid. We conclude that amyloid makes major contributions to biofilm mechanical robustness. PMID:26500638

  13. Ethnic Differences in Bending Stiffness of the Ulna and Tibia

    NASA Technical Reports Server (NTRS)

    Arnaud, S. B.; Liang, M. T. C.; Bassin, S.; Braun, W.; Dutto, D.; Plesums, K.; Huvnh, H. T.; Cooper, D.; Wong, N.

    2004-01-01

    There is considerable information about the variations in bone mass associated with different opportunity to compare a mechanical property of bone in young college women of Caucasian, Hispanic and Asian descent who gave informed consent to participate in an exercise study. The subjects were sedentary, in good health, eumenorrheic, non-smokers and had body mass indices (BMI) less than 30. Measurements acquired were body weight, kg, and height, cm, calcaneal and wrist bone density, g/square cm (PIXI, Lunar GE) and bending stiffness (EI, Nm(exp 2)) in the ulna and tibia. E1 was determined non-invasively with an instrument called the Mechanical Response Tissue Analyzer (MRTA) that delivers a vibratory stimulus to the center of the ulna or tibia and analyzes the response curve based on the equation E1 = k(sub b) L(exp 3)/48 where k, is lateral bending stiffness, L is the length of the bone, E is Young's modulus of elasticity and I, the bending moment of inertia. The error of the test (CV) based on measurements of an aluminum rod with a known E1 was 4.8%, of calcaneal BMD, 0.54%, and of wrist bone density, 3.45%.

  14. Functional aortic stiffness: role of CD4+ T lymphocytes

    PubMed Central

    Majeed, Beenish A.; Eberson, Lance S.; Tawinwung, Supannikar; Larmonier, Nicolas; Secomb, Timothy W.; Larson, Douglas F.

    2015-01-01

    The immune system is suggested to be essential in vascular remodeling and stiffening. To study the dependence upon lymphocytes in vascular stiffening, we compared an angiotensin II-model of vascular stiffening in normal C57BL/6J mice with lymphocyte-deficient RAG 1?/? mice and additionally characterized the component of vascular stiffness due to vasoconstriction vs. vascular remodeling. Chronic angiotensin II increased aortic pulse wave velocity, effective wall stiffness, and effective Young's modulus in C57BL/6J mice by three-fold but caused no change in the RAG 1?/? mice. These functional measurements were supported by aortic morphometric analysis. Adoptive transfer of CD4+ T helper lymphocytes restored the angiotensin II-mediated aortic stiffening in the RAG 1?/? mice. In order to account for the hydraulic vs. material effects of angiotensin II on pulse wave velocity, subcutaneous osmotic pumps were removed after 21 days of angiotensin II-infusion in the WT mice to achieve normotensive values. The pulse wave velocity (PWV) decreased from three- to two-fold above baseline values up to 7 days following pump removal. This study supports the pivotal role of the CD4+ T-lymphocytes in angiotensin II-mediated vascular stiffening and that angiotensin II-mediated aortic stiffening is due to the additive effect of active vascular smooth muscle vasoconstriction and vascular remodeling. PMID:26379554

  15. Explicit Integration of Extremely Stiff Reaction Networks: Partial Equilibrium Methods

    SciTech Connect

    Guidry, Mike W; Billings, J. J.; Hix, William Raphael

    2013-01-01

    In two preceding papers [1,2] we have shown that, when reaction networks are well removed from equilibrium, explicit asymptotic and quasi-steady-state approximations can give algebraically stabilized integration schemes that rival standard implicit methods in accuracy and speed for extremely stiff systems. However, we also showed that these explicit methods remain accurate but are no longer competitive in speed as the network approaches equilibrium. In this paper we analyze this failure and show that it is associated with the presence of fast equilibration timescales that neither asymptotic nor quasi-steady-state approximations are able to remove efficiently from the numerical integration. Based on this understanding, we develop a partial equilibrium method to deal effectively with the new partial equilibrium methods, give an integration scheme that plausibly can deal with the stiffest networks, even in the approach to equilibrium, with accuracy and speed competitive with that of implicit methods. Thus we demonstrate that algebraically stabilized explicit methods may offer alternatives to implicit integration of even extremely stiff systems, and that these methods may permit integration of much larger networks than have been feasible previously in a variety of fields.

  16. Cerebrovascular Damage Mediates Relations Between Aortic Stiffness and Memory.

    PubMed

    Cooper, Leroy L; Woodard, Todd; Sigurdsson, Sigurdur; van Buchem, Mark A; Torjesen, Alyssa A; Inker, Lesley A; Aspelund, Thor; Eiriksdottir, Gudny; Harris, Tamara B; Gudnason, Vilmundur; Launer, Lenore J; Mitchell, Gary F

    2016-01-01

    Aortic stiffness is associated with cognitive decline. Here, we examined the association between carotid-femoral pulse wave velocity and cognitive function and investigated whether cerebrovascular remodeling and parenchymal small vessel disease damage mediate the relation. Analyses were based on 1820 (60% women) participants in the Age, Gene/Environment Susceptibility-Reykjavik Study. Multivariable linear regression models adjusted for vascular and demographic confounders showed that higher carotid-femoral pulse wave velocity was related to lower memory score (standardized ?: -0.071±0.023; P=0.002). Cerebrovascular resistance and white matter hyperintensities were each associated with carotid-femoral pulse wave velocity and memory (P<0.05). Together, cerebrovascular resistance and white matter hyperintensities (total indirect effect: -0.029; 95% CI, -0.043 to -0.017) attenuated the direct relation between carotid-femoral pulse wave velocity and memory (direct effect: -0.042; 95% CI, -0.087 to 0.003; P=0.07) and explained ?41% of the observed effect. Our results suggest that in older adults, associations between aortic stiffness and memory are mediated by pathways that include cerebral microvascular remodeling and microvascular parenchymal damage. PMID:26573713

  17. ??? Cross-Links Increase Fibrin Fiber Elasticity and Stiffness

    PubMed Central

    Helms, Christine C.; Ariëns, Robert A.S.; Uitte de Willige, S.; Standeven, Kristina F.; Guthold, Martin

    2012-01-01

    Fibrin fibers, which are ?100 nm in diameter, are the major structural component of a blood clot. The mechanical properties of single fibrin fibers determine the behavior of a blood clot and, thus, have a critical influence on heart attacks, strokes, and embolisms. Cross-linking is thought to fortify blood clots; though, the role of ?–? cross-links in fibrin fiber assembly and their effect on the mechanical properties of single fibrin fibers are poorly understood. To address this knowledge gap, we used a combined fluorescence and atomic force microscope technique to determine the stiffness (modulus), extensibility, and elasticity of individual, uncross-linked, exclusively ?–? cross-linked (?Q398N/Q399N/K406R fibrinogen variant), and completely cross-linked fibrin fibers. Exclusive ?–? cross-linking results in 2.5× stiffer and 1.5× more elastic fibers, whereas full cross-linking results in 3.75× stiffer, 1.2× more elastic, but 1.2× less extensible fibers, as compared to uncross-linked fibers. On the basis of these results and data from the literature, we propose a model in which the ?-C region plays a significant role in inter- and intralinking of fibrin molecules and protofibrils, endowing fibrin fibers with increased stiffness and elasticity. PMID:22225811

  18. Memory Effects and Transport Coefficients for Non-Newtonian Fluids

    E-print Network

    T. Kodama; T. Koide

    2008-12-22

    We discuss the roles of viscosity in relativistic fluid dynamics from the point of view of memory effects. Depending on the type of quantity to which the memory effect is applied, different terms appear in higher order corrections. We show that when the memory effect applies on the extensive quantities, the hydrodynamic equations of motion become non-singular. We further discuss the question of memory effect in the derivation of transport coefficients from a microscopic theory. We generalize the application of the Green-Kubo-Nakano (GKN) to calculate transport coefficients in the framework of projection operator formalism, and derive the general formula when the fluid is non-Newtonian.

  19. The effect of the respiratory cycle on liver stiffness values as measured by transient elastography.

    PubMed

    Yun, M H; Seo, Y S; Kang, H S; Lee, K G; Kim, J H; An, H; Yim, H J; Keum, B; Jeen, Y T; Lee, H S; Chun, H J; Um, S H; Kim, C D; Ryu, H S

    2011-09-01

    The findings of several studies suggest that liver stiffness values can be affected by the degree of intrahepatic congestion respiration influence intrahepatic blood volume and may affect liver stiffness. We evaluated the influence of respiration on liver stiffness. Transient elastography (TE) was performed at the end of inspiration and at the end of expiration in patients with chronic liver disease. The median values obtained during the inspiration set and during the expiration set were defined as inspiratory and expiratory liver stiffness, respectively. A total of 123 patients with chronic liver disease were enrolled (mean age 49years; 64.2% men). Liver cirrhosis coexisted in 29 patients (23.6%). Expiratory liver stiffness was significantly higher than inspiratory liver stiffness (8.7 vs 7.9kPa, P=0.001), while the expiratory interquartile range/median ratio (IQR ratio) did not differ from the inspiratory IQR ratio. Expiratory liver stiffness was significantly higher than inspiratory liver stiffness in 49 (39.8%) patients (HE group), expiratory liver stiffness was significantly lower than inspiratory stiffness in 15 (12.2%) patients, and there was no difference in 59 (48.0%) patients. Liver cirrhosis was more frequent in those who had a lower liver stiffness reading in expiration, and only the absence of liver cirrhosis was significantly associated with a higher reading in expiration in multivariate analysis. In conclusion, liver stiffness was significantly elevated during expiration especially in patients without liver cirrhosis. The effect of respiration should be kept in mind during TE readings. PMID:21029256

  20. The differential effects of gender, anthropometry, and prior hormonal state on frontal plane knee joint stiffness

    PubMed Central

    Cammarata, Martha L.; Dhaher, Yasin Y.

    2012-01-01

    Background Gender differences in passive frontal plane knee stiffness may contribute to the increased anterior cruciate ligament injury rate in females. Gender-based stiffness differences have been attributed to anthropometric variations, but little data exist describing this relationship. Furthermore, sex hormone levels appear to influence joint stiffness, but the differential effects of instantaneous and prior hormonal concentrations remain unknown. This study sought to explore the effect of gender, prior hormonal status, and anthropometry on passive frontal plane knee joint stiffness. Methods Twelve males and 31 females participated. Females were grouped by hormonal contraceptive use (non users [n=11], monophasic contraceptive users [n=11], and triphasic contraceptive users [n=9]) and tested at the same point in the menstrual cycle. Subjects’ right knee was passively stretched ±7° in the frontal plane at 3°/s. Stiffness was estimated at three loading levels and normalized by body size to minimize anthropometric biases. A 4 (group) × 3 (load) repeated measures analysis of variance was performed for both raw and normalized stiffness. Linear regression analyses were preformed between stiffness estimates and knee diameter and quadriceps femoris angle. Findings Males displayed significantly greater (P<0.05) frontal plane stiffness than females. When normalized, males displayed significantly greater stiffness in valgus (P<0.05), but not varus (P>0.05) than females. No significant effect (P>0.05) of prior hormonal state was found; however, when normalized, varus stiffness was significantly less for triphasic contraceptive users than the other female groups (P<0.05). Quadriceps femoris angle was negatively correlated and knee diameter was positively correlated to knee stiffness. Interpretation Consistent with earlier in vitro findings, our data may indicate that ligament material properties are gender specific. A deficit in passive knee joint stiffness may place a larger burden on the neuromuscular system to resist frontal plane loading in females. PMID:18479791

  1. Extensional, bending and twisting stiffness of Titanium Multiwall Thermal Protection System (TPS)

    NASA Technical Reports Server (NTRS)

    Meaney, J. E.

    1982-01-01

    A test program which determines the extensional, bending and torsional stiffness of various titanium multiwall sandwich configurations is described. It is shown that unlike honeycomb core, the dimpled core is a significant contributor to the stiffness and strength of the sandwich. the extensional stiffness test shows irregularities which are attributed to foil thickness variations and to the difficulty to determine linear values from nonlinear tests.

  2. Bayesian semiparametric model with spatially-temporally varying coefficients selection.

    PubMed

    Cai, Bo; Lawson, Andrew B; Hossain, Monir; Choi, Jungsoon; Kirby, Russell S; Liu, Jihong

    2013-09-20

    In spatiotemporal analysis, the effect of a covariate on the outcome usually varies across areas and time. The spatial configuration of the areas may potentially depend on not only the structured random intercept but also spatially varying coefficients of covariates. In addition, the normality assumption of the distribution of spatially varying coefficients could lead to potential biases of estimations. In this article, we proposed a Bayesian semiparametric space-time model where the spatially-temporally varying coefficient is decomposed as fixed, spatially varying, and temporally varying coefficients. We nonparametrically modeled the spatially varying coefficients of space-time covariates by using the area-specific Dirichlet process prior with weights transformed via a generalized transformation. We modeled the temporally varying coefficients of covariates through the dynamic model. We also took into account the uncertainty of inclusion of the spatially-temporally varying coefficients by variable selection procedure through determining the probabilities of different effects for each covariate. The proposed semiparametric approach shows its improvement compared with the Bayesian spatial-temporal models with normality assumption on spatial random effects and the Bayesian model with the Dirichlet process prior on the random intercept. We presented a simulation example to evaluate the performance of the proposed approach with the competing models. We used an application to low birth weight data in South Carolina as an illustration. PMID:23526312

  3. Bayesian semiparametric model with spatially-temporally varying coefficients selection

    PubMed Central

    Cai, Bo; Lawson, Andrew B.; Hossain, Md. Monir; Choi, Jungsoon; Kirby, Russell S.; Liu, Jihong

    2013-01-01

    In spatio-temporal analysis, the effect of a covariate on the outcome usually varies across areas and time. The spatial configuration of the areas may potentially depend on not only the structured random intercept but also spatially varying coefficients of covariates. In addition, the normality assumption of the distribution of spatially varying coefficients could lead to potential biases of estimations. In this article, we propose a Bayesian semiparametric space-time model where the spatially-temporally varying coefficient is decomposed as fixed, spatially varying and temporally varying coefficients. The spatially varying coefficients of space-time covariates are modeled nonparametrically by using the area-specific Dirichlet process prior with weights transformed via a generalized transformation. Temporally varying coefficients of covariates are modeled through the dynamic model. Uncertainty of inclusion of the spatially-temporally varying coefficients is also taken into account by variable selection procedure through determining the probabilities of different effects for each covariate. The proposed semiparametric approach shows the improvement compared to the Bayesian spatial-temporal models with normality assumption on spatial random effects and the Bayesian model with the Dirichlet process prior on the random intercept. A simulation example is presented to evaluate the performance of the proposed approach with the competing models. An application to low birth weight data in South Carolina is used for an illustration. PMID:23526312

  4. ORTHOGONAL POLYNOMIALS WITH RECURSION COEFFICIENTS OF GENERALIZED BOUNDED

    E-print Network

    line, we prove that in the Lebesgue decomposition dµ = fdm+dµs of such measures, supp(dµs)(-2, 2 variation, Wigner­von Neumann potential. Mathematics 253-37, California Institute of Technology, Pasadena

  5. Biomechanical Effects of Stiffness in Parallel With the Knee Joint During Walking.

    PubMed

    Shamaei, Kamran; Cenciarini, Massimo; Adams, Albert A; Gregorczyk, Karen N; Schiffman, Jeffrey M; Dollar, Aaron M

    2015-10-01

    The human knee behaves similarly to a linear torsional spring during the stance phase of walking with a stiffness referred to as the knee quasi-stiffness. The spring-like behavior of the knee joint led us to hypothesize that we might partially replace the knee joint contribution during stance by utilizing an external spring acting in parallel with the knee joint. We investigated the validity of this hypothesis using a pair of experimental robotic knee exoskeletons that provided an external stiffness in parallel with the knee joints in the stance phase. We conducted a series of experiments involving walking with the exoskeletons with four levels of stiffness, including 0%, 33%, 66%, and 100% of the estimated human knee quasi-stiffness, and a pair of joint-less replicas. The results indicated that the ankle and hip joints tend to retain relatively invariant moment and angle patterns under the effects of the exoskeleton mass, articulation, and stiffness. The results also showed that the knee joint responds in a way such that the moment and quasi-stiffness of the knee complex (knee joint and exoskeleton) remains mostly invariant. A careful analysis of the knee moment profile indicated that the knee moment could fully adapt to the assistive moment; whereas, the knee quasi-stiffness fully adapts to values of the assistive stiffness only up to ?80%. Above this value, we found biarticular consequences emerge at the hip joint. PMID:25955513

  6. Vanishing spin stiffness in the spin-1/2 Heisenberg chain for any nonzero temperature

    NASA Astrophysics Data System (ADS)

    Carmelo, J. M. P.; Prosen, T.; Campbell, D. K.

    2015-10-01

    Whether at the zero spin density m =0 and finite temperatures T >0 the spin stiffness of the spin-1 /2 X X X chain is finite or vanishes remains an unsolved and controversial issue, as different approaches yield contradictory results. Here we explicitly compute the stiffness at m =0 and find strong evidence that it vanishes. In particular, we derive an upper bound on the stiffness within a canonical ensemble at any fixed value of spin density m that is proportional to m2L in the thermodynamic limit of chain length L ?? , for any finite, nonzero temperature, which implies the absence of ballistic transport for T >0 for m =0 . Although our method relies in part on the thermodynamic Bethe ansatz (TBA), it does not evaluate the stiffness through the second derivative of the TBA energy eigenvalues relative to a uniform vector potential. Moreover, we provide strong evidence that in the thermodynamic limit the upper bounds on the spin current and stiffness used in our derivation remain valid under string deviations. Our results also provide strong evidence that in the thermodynamic limit the TBA method used by X. Zotos [Phys. Rev. Lett. 82, 1764 (1999), 10.1103/PhysRevLett.82.1764] leads to the exact stiffness values at finite temperature T >0 for models whose stiffness is finite at T =0 , similar to the spin stiffness of the spin-1 /2 Heisenberg chain but unlike the charge stiffness of the half-filled 1D Hubbard model.

  7. Stiff Man Syndrome: A Diagnostic Dilemma in a Young Female with Diabetes Mellitus and Thyroiditis

    PubMed Central

    Enuh, Hilary; Park, Michael; Ghodasara, Arjun; Arsura, Edward; Nfonoyim, Jay

    2014-01-01

    Stiff Person Syndrome (SPS), is a very rare neuroimmunologic disorder characterized by progressive muscle pain, rigidity, stiffness, and spasms. It can be very debilitating if misdiagnosed or not recognized in time. Herein we discuss a case of a female in her 20s who presented with an unsteady gait, lower extremity weakness, persistent leg pain, and stiffness few weeks after uncomplicated childbirth. She has type 1 diabetes mellitus (DM) and was diagnosed with thyroiditis in the course of her illness. The triad of thyroiditis, DM, and stiffness with normal neuroimaging in a young female patient is an unusual occurrence. PMID:25525403

  8. Review of ‘the potential role of arterial stiffness in the pathogenesis of Alzheimer’s disease’

    PubMed Central

    Hughes, Timothy M; Craft, Suzanne; Lopez, Oscar L

    2015-01-01

    SUMMARY Arterial stiffness is emerging as an important risk marker for poor brain aging and dementia through its associations with cerebral small vessel disease, stroke, ?-amyloid deposition, brain atrophy and cognitive impairment. Arterial stiffness directly relates the detrimental effects of hypertension on peripheral organs with dire consequences for the extensive microvasculature structure of the kidneys and brain. In this review, we discuss the evidence linking arterial stiffness, hypertension and brain structural abnormalities in older adults. In particular, we discuss the potential mechanisms linking arterial stiffness to brain ?-amyloid deposition and dementia and potential therapeutic strategies to prevent hypertension’s adverse effects on the brain. PMID:25894876

  9. Impact of morning stiffness on working behaviour and performance in people with rheumatoid arthritis.

    PubMed

    Mattila, Kalle; Buttgereit, Frank; Tuominen, Risto

    2014-12-01

    Work disability remains a considerable problem for many patients with rheumatoid arthritis (RA). Morning stiffness is a symptom of RA associated with early retirement from work and with impaired functional ability. We aimed to explore the patient's perception of the impact of morning stiffness on the working life of patients with RA. A survey was conducted in 11 European countries. Patients of working age, with RA for ?6 months and morning stiffness ?3 mornings a week, were interviewed by telephone using a structured questionnaire. Responses were assessed in the total sample and in subgroups defined by severity and duration of morning stiffness and by country. A total of 1,061 respondents completed the survey, 534 were working, 224 were retired and the rest were, i.e. homemakers and unemployed. Among the 534 working respondents, RA-related morning stiffness affected work performance (47 %), resulted in late arrival at work (33 %) and required sick leave in the past month (15 %). Of the 224 retired respondents, 159 (71 %) stopped working earlier than their expected retirement age, with 64 % giving RA-related morning stiffness as a reason. There was a differential impact of increasing severity and increasing duration of morning stiffness on the various parameters studied. There were notable inter-country differences in the impact of RA-related morning stiffness on ability to work and on retirement. This large survey showed that from the patient's perspective, morning stiffness reduces the ability to work in patients with RA and contributes to early retirement. PMID:24871158

  10. Correlation equation for the marine drag coefficient and wave steepness

    NASA Astrophysics Data System (ADS)

    Foreman, Richard J.; Emeis, Stefan

    2012-09-01

    This work questions, starting from dimensional considerations, the generality of the belief that the marine drag coefficient levels off with increasing wind speed. Dimensional analysis shows that the drag coefficient scales with the wave steepness as opposed to a wave-age scaling. A correlation equation is employed here that uses wave steepness scaling at low aspect ratios (inverse wave steepnesses) and a constant drag coefficient at high aspect ratios. Invoked in support of the correlation are measurements sourced from the literature and at the FINO1 platform in the North Sea. The correlation equation is then applied to measurements recorded from buoys during the passage of hurricanes Rita, Katrina (2005) and Ike (2008). Results show that the correlation equation anticipates the expected levelling off in deeper water, but a drag coefficient more consistent with a Charnock type relation is also possible in more shallower water. Some suggestions are made for proceeding with a higher-order analysis than that conducted here.

  11. High temperature Seebeck coefficient metrology

    SciTech Connect

    Martin, J.; Tritt, T.; Uher, C.

    2010-12-15

    We present an overview of the challenges and practices of thermoelectric metrology on bulk materials at high temperature (300 to 1300 K). The Seebeck coefficient, when combined with thermal and electrical conductivity, is an essential property measurement for evaluating the potential performance of novel thermoelectric materials. However, there is some question as to which measurement technique(s) provides the most accurate determination of the Seebeck coefficient at high temperature. This has led to the implementation of nonideal practices that have further complicated the confirmation of reported high ZT materials. To ensure meaningful interlaboratory comparison of data, thermoelectric measurements must be reliable, accurate, and consistent. This article will summarize and compare the relevant measurement techniques and apparatus designs required to effectively manage uncertainty, while also providing a reference resource of previous advances in high temperature thermoelectric metrology.

  12. Consistent transport coefficients in astrophysics

    NASA Technical Reports Server (NTRS)

    Fontenla, Juan M.; Rovira, M.; Ferrofontan, C.

    1986-01-01

    A consistent theory for dealing with transport phenomena in stellar atmospheres starting with the kinetic equations and introducing three cases (LTE, partial LTE, and non-LTE) was developed. The consistent hydrodynamical equations were presented for partial-LTE, the transport coefficients defined, and a method shown to calculate them. The method is based on the numerical solution of kinetic equations considering Landau, Boltzmann, and Focker-Planck collision terms. Finally a set of results for the transport coefficients derived for a partially ionized hydrogen gas with radiation was shown, considering ionization and recombination as well as elastic collisions. The results obtained imply major changes is some types of theoretical model calculations and can resolve some important current problems concerning energy and mass balance in the solar atmosphere. It is shown that energy balance in the lower solar transition region can be fully explained by means of radiation losses and conductive flux.

  13. Portable vapor diffusion coefficient meter

    DOEpatents

    Ho, Clifford K. (Albuquerque, NM)

    2007-06-12

    An apparatus for measuring the effective vapor diffusion coefficient of a test vapor diffusing through a sample of porous media contained within a test chamber. A chemical sensor measures the time-varying concentration of vapor that has diffused a known distance through the porous media. A data processor contained within the apparatus compares the measured sensor data with analytical predictions of the response curve based on the transient diffusion equation using Fick's Law, iterating on the choice of an effective vapor diffusion coefficient until the difference between the predicted and measured curves is minimized. Optionally, a purge fluid can forced through the porous media, permitting the apparatus to also measure a gas-phase permeability. The apparatus can be made lightweight, self-powered, and portable for use in the field.

  14. Leg and Joint Stiffness in Children with Spastic Diplegic Cerebral Palsy during Level Walking

    PubMed Central

    Wang, Ting-Ming; Huang, Hsing-Po; Li, Jia-Da; Hong, Shih-Wun; Lo, Wei-Ching; Lu, Tung-Wu

    2015-01-01

    Individual joint deviations are often identified in the analysis of cerebral palsy (CP) gait. However, knowledge is limited as to how these deviations affect the control of the locomotor system as a whole when striving to meet the demands of walking. The current study aimed to bridge the gap by describing the control of the locomotor system in children with diplegic CP in terms of their leg stiffness, both skeletal and muscular components, and associated joint stiffness during gait. Twelve children with spastic diplegia CP and 12 healthy controls walked at a self-selected pace in a gait laboratory while their kinematic and forceplate data were measured and analyzed during loading response, mid-stance, terminal stance and pre-swing. For calculating the leg stiffness, each of the lower limbs was modeled as a non-linear spring, connecting the hip joint center and the corresponding center of pressure, with varying stiffness that was calculated as the slope (gradient) of the axial force vs. the deformation curve. The leg stiffness was further decomposed into skeletal and muscular components considering the alignment of the lower limb. The ankle, knee and hip of the limb were modeled as revolute joints with torsional springs whose stiffness was calculated as the slope of the moment vs. the angle curve of the joint. Independent t-tests were performed for between-group comparisons of all the variables. The CP group significantly decreased the leg stiffness but increased the joint stiffness during stance phase, except during terminal stance where the leg stiffness was increased. They appeared to rely more on muscular contributions to achieve the required leg stiffness, increasing the muscular demands in maintaining the body posture against collapse. Leg stiffness plays a critical role in modulating the kinematics and kinetics of the locomotor system during gait in the diplegic CP. PMID:26629700

  15. Bayesian normal modes identification and estimation of elastic coefficients in resonant ultrasound spectroscopy

    NASA Astrophysics Data System (ADS)

    Bernard, Simon; Marrelec, Guillaume; Laugier, Pascal; Grimal, Quentin

    2015-06-01

    Resonant ultrasound spectroscopy is an experimental technique for measuring the stiffness of anisotropic solid materials. The free vibration resonant frequencies of a specimen are measured and the stiffness coefficients of the material adjusted to minimize the difference between experimental and predicted frequencies. An issue of this inverse approach is that the measured frequencies are not easily paired with their predicted counterpart, leading to ambiguities in the definition of the objective function. In the past, this issue has been overcome through trial-and-error methods requiring the experimentalist to find the correct pairing, or through involved experimental methods measuring the shapes of the normal vibration modes in addition to their frequencies. The purpose of this work is to show, through a Bayesian formulation, that the inverse problem can be solved automatically and without requiring additions to the usual experimental setup. The pairing of measured and predicted frequencies is considered unknown, and the joint posterior probability distribution of pairing and stiffness is sampled using Markov chain Monte Carlo. The method is illustrated on two published data sets. The first set includes the exact pairing, allowing validation of the method. The second application deals with attenuative materials, for which many predicted modes cannot be observed, further complicating the inverse problem. In that case, introduction of prior information through Bayesian formulation reduces ambiguities.

  16. On the difference between stiff and soft membranes: Capillary Waves

    E-print Network

    Jaksch, Sebastian; Ohl, Michael; Frielinghaus, Henrich

    2015-01-01

    One problem of non-crystalline condensed matter (soft matter) is creating the right equilibrium between elasticity and viscosity, referred to as viscoelasticity. Manifestations of that can be found in everyday live, where the viscoelasticity in a tire needs to be balanced so it is still flexible and can dissipate shock-energy, yet hard enough for energy-saving operation. Similarly, the cartilage in joints needs to absorb shocks while operating at low- level friction with high elasticity. Two such examples with a biological applicability are stiff membranes, which allow for the sliding of joints and therefore maintain their function over the lifetime of the corresponding individual (decades) and the softening of cell membranes, for example for antimicrobial effects by dissolution in the case of bacteria (seconds). While the first should allow for low- friction operation at high elasticity, in the second scenario energy dissipated into the membrane eventually leads to membrane destruction. Here we address the i...

  17. Cell stiffness, contractile stress and the role of extracellular matrix

    SciTech Connect

    An, Steven S.; Kim, Jina; Ahn, Kwangmi; Trepat, Xavier; Drake, Kenneth J.; Kumar, Sarvesh; Ling, Guoyu; Purington, Carolyn; Rangasamy, Tirumalai; Kensler, Thomas W.; Mitzner, Wayne; Fredberg, Jeffrey J.; Biswal, Shyam; Division of Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205

    2009-05-15

    Here we have assessed the effects of extracellular matrix (ECM) composition and rigidity on mechanical properties of the human airway smooth muscle (ASM) cell. Cell stiffness and contractile stress showed appreciable changes from the most relaxed state to the most contracted state: we refer to the maximal range of these changes as the cell contractile scope. The contractile scope was least when the cell was adherent upon collagen V, followed by collagen IV, laminin, and collagen I, and greatest for fibronectin. Regardless of ECM composition, upon adherence to increasingly rigid substrates, the ASM cell positively regulated expression of antioxidant genes in the glutathione pathway and heme oxygenase, and disruption of a redox-sensitive transcription factor, nuclear erythroid 2 p45-related factor (Nrf2), culminated in greater contractile scope. These findings provide biophysical evidence that ECM differentially modulates muscle contractility and, for the first time, demonstrate a link between muscle contractility and Nrf2-directed responses.

  18. The ocular phenotype of stiff-skin syndrome.

    PubMed

    Chamney, S; Cartmill, B; Earley, O; McConnell, V; Willoughby, C E

    2016-01-01

    PurposeStiff skin syndrome (SSS; MIM#184900) is a rare autosomal dominantly inherited Mendelian disorder characterised by thickened and stone-hard indurations of the skin, mild hypertrichosis, and limitation of joint mobility with flexion contractures. It is autosomal dominant with high penetrance and results from mutations in the fibrillin 1 (FBN1; MIM*134797) gene. Here we present the associated ocular phenotype in a two generation nonconsanguineous Northern Irish family.MethodsThe affected patients underwent complete ophthalmic and orthoptic assessment and genetic testing.ResultsAll three patients had ophthalmoplegia of varying degrees. Direct sequencing of the FBN1 gene detected a heterozygous pathogenic mutation (c.4710G>C; p.Trp1570Cys) in all affected patients.ConclusionsThis is the first report of ophthalmoplegia in association with SSS. PMID:26471116

  19. Underwater MASW to evaluate stiffness of water-bottom sediments

    USGS Publications Warehouse

    Park, C.B.; Miller, R.D.; Xia, J.; Ivanov, J.; Sonnichsen, G.V.; Hunter, J.A.; Good, R.L.; Burns, R.A.; Christian, H.

    2005-01-01

    The multichannel analysis of surface waves (MASW) is initially intended as a land survey method to investigate the near-surface materials for their elastic properties. The acquired data are first analyzed for dispersion characteristics and, from these the shear-wave velocity is estimated using an inversion technique. Land applications show the potential of the MASW method to map 2D bedrock surface, zones of low strength, Poisson's ratio, voids, as well as to generate shear-wave profiles for various othe geotechnical problems. An overview is given of several underwater applications of the MASW method to characterize stiffness distribution of water-bottom sediments. The first application details the survey under shallow-water (1-6 m) in the Fraser River (Canada). The second application is an innovative experimental marine seismic survey in the North Atlantic Ocean near oil fields in Grand Bank offshore Newfoundland.

  20. Arterial Stiffness: A Nexus between Cardiac and Renal Disease

    PubMed Central

    Jia, Guanghong; Aroor, Annayya R.; Sowers, James R.

    2014-01-01

    Vascular disease is the leading cause of morbidity and mortality in the Western world, and vascular function is determined by structural and functional properties of the arterial vascular wall. Cardiorenal metabolic syndrome such as obesity, diabetes, hypertension, kidney disease, and aging are conditions that predispose to arterial stiffening, which is a pathological alteration of the vascular wall and ultimately results in target organ damage in heart and kidney. In this review, we provide new insights on the interactions between arterial stiffness, vascular resistance and pulse wave velocity as well as final end-organ damage in heart and kidney. Better understanding of the mechanisms of arterial functional and hemodynamic alteration may help in developing more refined therapeutic strategies aimed to reduce cardiovascular and chronic kidney diseases. PMID:24847335

  1. Effect of Bearing Dynamic Stiffness on Gear Vibration

    NASA Technical Reports Server (NTRS)

    Fleming, David P.

    2002-01-01

    Noise is a major consideration in the design of high performance geared transmissions, such as for helicopters. Transmission error, that is, the accuracy with which the driven gear follows the driver gear, is a common indicator of noise generation. It is well known that bearing properties have a strong influence on shaft dynamics. However, up to now the contribution of bearings to transmission error has received little attention. In this paper, a torsional-axial-lateral geared rotor analysis is used to determine dynamic transmission error as a function of bearing stiffness and damping. Bearings have a similar effect as found in shaft dynamics; transmission error can be reduced more than 10 decibels by appropriate selection of bearing properties.

  2. Coefficient adaptive triangulation for strongly anisotropic problems

    SciTech Connect

    D`Azevedo, E.F.; Romine, C.H.; Donato, J.M.

    1996-01-01

    Second order elliptic partial differential equations arise in many important applications, including flow through porous media, heat conduction, the distribution of electrical or magnetic potential. The prototype is the Laplace problem, which in discrete form produces a coefficient matrix that is relatively easy to solve in a regular domain. However, the presence of anisotropy produces a matrix whose condition number is increased, making the resulting linear system more difficult to solve. In this work, we take the anisotropy into account in the discretization by mapping each anisotropic region into a ``stretched`` coordinate space in which the anisotropy is removed. The region is then uniformly triangulated, and the resulting triangulation mapped back to the original space. The effect is to generate long slender triangles that are oriented in the direction of ``preferred flow.`` Slender triangles are generally regarded as numerically undesirable since they tend to cause poor conditioning; however, our triangulation has the effect of producing effective isotropy, thus improving the condition number of the resulting coefficient matrix.

  3. Hierarchical coefficient of a multifractal based network

    NASA Astrophysics Data System (ADS)

    Moreira, Darlan A.; Lucena, Liacir dos Santos; Corso, Gilberto

    2014-02-01

    The hierarchical property for a general class of networks stands for a power-law relation between clustering coefficient, CC and connectivity k: CC?k?. This relation is empirically verified in several biologic and social networks, as well as in random and deterministic network models, in special for hierarchical networks. In this work we show that the hierarchical property is also present in a Lucena network. To create a Lucena network we use the dual of a multifractal lattice ML, the vertices are the sites of the ML and links are established between neighbouring lattices, therefore this network is space filling and planar. Besides a Lucena network shows a scale-free distribution of connectivity. We deduce a relation for the maximal local clustering coefficient CCimax of a vertex i in a planar graph. This condition expresses that the number of links among neighbour, N?, of a vertex i is equal to its connectivity ki, that means: N?=ki. The Lucena network fulfils the condition N??ki independent of ki and the anisotropy of ML. In addition, CCmax implies the threshold ?=1 for the hierarchical property for any scale-free planar network.

  4. Rotordynamic coefficients for stepped labyrinth gas seals

    NASA Technical Reports Server (NTRS)

    Scharrer, Joseph K.

    1989-01-01

    The basic equations are derived for compressible flow in a stepped labyrinth gas seal. The flow is assumed to be completely turbulent in the circumferential direction where the friction factor is determined by the Blasius relation. Linearized zeroth and first-order perturbation equations are developed for small motion about a centered position by an expansion in the eccentricity ratio. The zeroth-order pressure distribution is found by satisfying the leakage equation while the circumferential velocity distribution is determined by satisfying the momentum equations. The first order equations are solved by a separation of variables solution. Integration of the resultant pressure distribution along and around the seal defines the reaction force developed by the seal and the corresponding dynamic coefficients. The results of this analysis are presented in the form of a parametric study, since there are no known experimental data for the rotordynamic coefficients of stepped labyrinth gas seals. The parametric study investigates the relative rotordynamic stability of convergent, straight and divergent stepped labyrinth gas seals. The results show that, generally, the divergent seal is more stable, rotordynamically, than the straight or convergent seals. The results also show that the teeth-on-stator seals are not always more stable, rotordynamically, then the teeth-on-rotor seals as was shown by experiment by Childs and Scharrer (1986b) for a 15 tooth seal.

  5. The role of pulmonary arterial stiffness in COPD.

    PubMed

    Weir-McCall, Jonathan R; Struthers, Allan D; Lipworth, Brian J; Houston, J Graeme

    2015-11-01

    COPD is the second most common cause of pulmonary hypertension, and is a common complication of severe COPD with significant implications for both quality of life and mortality. However, the use of a rigid diagnostic threshold of a mean pulmonary arterial pressure (mPAP) of ?25mHg when considering the impact of the pulmonary vasculature on symptoms and disease is misleading. Even minimal exertion causes oxygen desaturation and elevations in mPAP, with right ventricular hypertrophy and dilatation present in patients with mild to moderate COPD with pressures below the threshold for diagnosis of pulmonary hypertension. This has significant implications, with right ventricular dysfunction associated with poorer exercise capability and increased mortality independent of pulmonary function tests. The compliance of the pulmonary artery (PA) is a key component in decoupling the right ventricle from the pulmonary bed, allowing the right ventricle to work at maximum efficiency and protecting the microcirculation from large pressure gradients. PA stiffness increases with the severity of COPD, and correlates well with the presence of exercise induced pulmonary hypertension. A curvilinear relationship exists between PA distensibility and mPAP and pulmonary vascular resistance (PVR) with marked loss of distensibility before a rapid rise in mPAP and PVR occurs with resultant right ventricular failure. This combination of features suggests PA stiffness as a promising biomarker for early detection of pulmonary vascular disease, and to play a role in right ventricular failure in COPD. Early detection would open this up as a potential therapeutic target before end stage arterial remodelling occurs. PMID:26095859

  6. VAGINAL DEGENERATION FOLLOWING IMPLANTATION OF SYNTHETIC MESH WITH INCREASED STIFFNESS

    PubMed Central

    Liang, Rui; Abramowitch, Steven; Knight, Katrina; Palcsey, Stacy; Nolfi, Alexis; Feola, Andrew; Stein, Susan; Moalli, Pamela A.

    2012-01-01

    Objective To compare the impact of the prototype prolapse mesh Gynemesh PS to that of two new generation lower stiffness meshes, UltraPro and SmartMesh, on vaginal morphology and structural composition. Design A mechanistic study employing a non-human primate (NHP) model. Setting Magee-Womens Research Institute at the University of Pittsburgh. Population Parous rhesus macaques, with similar age, weight, parity and POP-Q scores. Methods Following IACUC approval, 50 rhesus macaques were implanted with Gynemesh PS (n=12), UltraPro with its blue line perpendicular to the longitudinal axis of vagina (n=10), UltraPro with its blue line parallel to the longitudinal axis of vagina (n=8) and SmartMesh (n=8) via sacrocolpopexy following hysterectomy. Sham operated animals (n=12) served as controls. Main Outcome Measures The mesh-vagina complex (MVC) was removed after 12 weeks and analyzed for histomorphology, in situ cell apoptosis, total collagen, elastin, glycosaminoglycan content and total collagenase activity. Appropriate statistics and correlation analyses were performed accordingly. Results Relative to sham and the two lower stiffness meshes, Gynemesh PS had the greatest negative impact on vaginal histomorphology and composition. Compared to sham, implantation with Gynemesh PS caused substantial thinning of the smooth muscle layer (1557 ± 499?m vs 866 ± 210 ?m, P=0.02), increased apoptosis particularly in the area of the mesh fibers (P=0.01), decreased collagen and elastin content (20% (P=0.03) and 43% (P=0.02), respectively) and increased total collagenase activity (135% (P=0.01)). GAG (glycosaminoglycan), a marker of tissue injury, was the highest with Gynemesh PS compared to sham and other meshes (P=0.01). Conclusion Mesh implantation with the stiffer mesh Gynemesh PS induced a maladaptive remodeling response consistent with vaginal degeneration. PMID:23240802

  7. On the difference between stiff and soft membranes: Capillary Waves

    E-print Network

    Sebastian Jaksch; Olaf Holderer; Michael Ohl; Henrich Frielinghaus

    2015-08-14

    One problem of non-crystalline condensed matter (soft matter) is creating the right equilibrium between elasticity and viscosity, referred to as viscoelasticity. Manifestations of that can be found in everyday live, where the viscoelasticity in a tire needs to be balanced so it is still flexible and can dissipate shock-energy, yet hard enough for energy-saving operation. Similarly, the cartilage in joints needs to absorb shocks while operating at low- level friction with high elasticity. Two such examples with a biological applicability are stiff membranes, which allow for the sliding of joints and therefore maintain their function over the lifetime of the corresponding individual (decades) and the softening of cell membranes, for example for antimicrobial effects by dissolution in the case of bacteria (seconds). While the first should allow for low- friction operation at high elasticity, in the second scenario energy dissipated into the membrane eventually leads to membrane destruction. Here we address the intrinsic difference between these two types of membranes, differing in stiffness and displaying different relaxation behavior on the nanosecond time scale. The harder membranes show additional elastic modes, capillary waves, that indicate the high degree of elasticity necessary for instance in cartilage or red blood cells. The energy of these modes is in the order of 1 micro-eV. As model systems we chose a hard phospholipidmembrane of SoyPC lipids and a D2O/C10E4/decane microemulsion system representing soft surfactant membranes. Our results help to explain properties observed for many membranes in nature, where hard membranes lubricate joints or stay intact as red blood particles in tiniest capillaries, both with extremely long lifetimes. Contrarily, softened membranes can be destroyed easily under little shear stress within seconds.

  8. DNA on a Tube: Electrostatic Contribution to Stiffness

    PubMed Central

    Guo, Zuojun; Taubes, Clifford Henry; Oh, Jee-Eun; Maher, Louis J.

    2015-01-01

    Two simple models are used to estimate the electrostatic contributions to the stiffness of short DNA fragments. The first model views DNA as two strands that are appropriately parametrized and are wrapped helically around a straight cylinder radius equal to the radius of the DNA molecule. The potential energy of the DNA due to phosphate–phosphate electrostatic interactions is evaluated assuming that the charges interact through Debye–Hückel potentials. This potential energy is compared with the potential energy as computed using our second model in which DNA is viewed as two helical strands wrapping around a curved tube whose cross-section is a disk of radius equal to the radius of the DNA. We find that the electrostatic persistence length for B-DNA molecules in the range of 105–130 bp is 125.64 Å (37 bp) and 76.05 Å (23 bp) at 5 and 10 mM monovalent salt concentration, respectively. If the condensed fraction ? is taken to be 0.715 at 10 mM, then the electrostatic persistence length is 108.28 Å (32 bp), while that based on taking into account end effects is 72.87 Å (21 bp). At 5 mM monovalent salt, the total persistence length for DNA fragments in this length range is approximately 575.64 Å (171 bp), using the best estimate for nonelectrostatic contribution to persistence length. Electrostatic effects thus contribute 21.8% to DNA stiffness at 5 mM for fragments between 105- to 130-bp. In contrast, electrostatics are calculated to make a negligible contribution to the DNA persistence length at physiological monovalent cation concentration. The results are compared with counterion condensation models and experimental data. PMID:19053713

  9. The role of pulmonary arterial stiffness in COPD

    PubMed Central

    Weir-McCall, Jonathan R.; Struthers, Allan D.; Lipworth, Brian J.; Houston, J. Graeme

    2015-01-01

    COPD is the second most common cause of pulmonary hypertension, and is a common complication of severe COPD with significant implications for both quality of life and mortality. However, the use of a rigid diagnostic threshold of a mean pulmonary arterial pressure (mPAP) of ?25mHg when considering the impact of the pulmonary vasculature on symptoms and disease is misleading. Even minimal exertion causes oxygen desaturation and elevations in mPAP, with right ventricular hypertrophy and dilatation present in patients with mild to moderate COPD with pressures below the threshold for diagnosis of pulmonary hypertension. This has significant implications, with right ventricular dysfunction associated with poorer exercise capability and increased mortality independent of pulmonary function tests. The compliance of the pulmonary artery (PA) is a key component in decoupling the right ventricle from the pulmonary bed, allowing the right ventricle to work at maximum efficiency and protecting the microcirculation from large pressure gradients. PA stiffness increases with the severity of COPD, and correlates well with the presence of exercise induced pulmonary hypertension. A curvilinear relationship exists between PA distensibility and mPAP and pulmonary vascular resistance (PVR) with marked loss of distensibility before a rapid rise in mPAP and PVR occurs with resultant right ventricular failure. This combination of features suggests PA stiffness as a promising biomarker for early detection of pulmonary vascular disease, and to play a role in right ventricular failure in COPD. Early detection would open this up as a potential therapeutic target before end stage arterial remodelling occurs. PMID:26095859

  10. THE NUMBER OF NONZERO BINOMIAL COEFFICIENTS MODULO p

    E-print Network

    Rowland, Eric

    of Pascal's triangle modulo k by using Lucas' theorem to determine a2(n) = 2|n|1 . The proof is simple an expression for the number ap(n) of bi- nomial coefficients on row n of Pascal's triangle that are nonzero modulo p. In this paper we use Kummer's theorem to generalize Fine's theorem to prime powers, expressing

  11. Evolutionary game on networks with high clustering coefficient

    E-print Network

    Morita, Satoru

    2015-01-01

    This study investigates the influence of lattice structure in evolutionary games. The snowdrift games is considered in networks with high clustering coefficients, that use four different strategy-updating. Analytical conjectures using pair approximation were compared with the numerical results. Results indicate that general statements asserting that the lattice structure enhances cooperation are misleading.

  12. Visualising the Complex Roots of Quadratic Equations with Real Coefficients

    ERIC Educational Resources Information Center

    Bardell, Nicholas S.

    2012-01-01

    The roots of the general quadratic equation y = ax[superscript 2] + bx + c (real a, b, c) are known to occur in the following sets: (i) real and distinct; (ii) real and coincident; and (iii) a complex conjugate pair. Case (iii), which provides the focus for this investigation, can only occur when the values of the real coefficients a, b, and c are…

  13. A Simple Method for Calculating Clebsch-Gordan Coefficients

    ERIC Educational Resources Information Center

    Klink, W. H.; Wickramasekara, S.

    2010-01-01

    This paper presents a simple method for calculating Clebsch-Gordan coefficients for the tensor product of two unitary irreducible representations (UIRs) of the rotation group. The method also works for multiplicity-free irreducible representations appearing in the tensor product of any number of UIRs of the rotation group. The generalization to…

  14. A simple method for calculating Clebsch-Gordan coefficients

    NASA Astrophysics Data System (ADS)

    Klink, W. H.; Wickramasekara, S.

    2010-09-01

    This paper presents a simple method for calculating Clebsch-Gordan coefficients for the tensor product of two unitary irreducible representations (UIRs) of the rotation group. The method also works for multiplicity-free irreducible representations appearing in the tensor product of any number of UIRs of the rotation group. The generalization to representations with multiplicity is straightforward and briefly discussed.

  15. Transport Coefficients in weakly compressible turbulence

    NASA Technical Reports Server (NTRS)

    Rubinstein, Robert; Erlebacher, Gordon

    1996-01-01

    A theory of transport coefficients in weakly compressible turbulence is derived by applying Yoshizawa's two-scale direct interaction approximation to the compressible equations of motion linearized about a state of incompressible turbulence. The result is a generalization of the eddy viscosity representation of incompressible turbulence. In addition to the usual incompressible eddy viscosity, the calculation generates eddy diffusivities for entropy and pressure, and an effective bulk viscosity acting on the mean flow. The compressible fluctuations also generate an effective turbulent mean pressure and corrections to the speed of sound. Finally, a prediction unique to Yoshizawa's two-scale approximation is that terms containing gradients of incompressible turbulence quantities also appear in the mean flow equations. The form these terms take is described.

  16. Non-cross-bridge calcium-dependent stiffness in frog muscle fibers.

    PubMed

    Bagni, M A; Colombini, B; Geiger, P; Berlinguer Palmini, R; Cecchi, G

    2004-06-01

    At the end of the force transient elicited by a fast stretch applied to an activated frog muscle fiber, the force settles to a steady level exceeding the isometric level preceding the stretch. We showed previously that this excess of tension, referred to as "static tension," is due to the elongation of some elastic sarcomere structure, outside the cross bridges. The stiffness of this structure, "static stiffness," increased upon stimulation following a time course well distinct from tension and roughly similar to intracellular Ca(2+) concentration. In the experiments reported here, we investigated the possible role of Ca(2+) in static stiffness by comparing static stiffness measurements in the presence of Ca(2+) release inhibitors (D600, Dantrolene, (2)H(2)O) and cross-bridge formation inhibitors [2,3-butanedione monoxime (BDM), hypertonicity]. Both series of agents inhibited tension; however, only D600, Dantrolene, and (2)H(2)O decreased at the same time static stiffness, whereas BDM and hypertonicity left static stiffness unaltered. These results indicate that Ca(2+), in addition to promoting cross-bridge formation, increases the stiffness of an (unidentified) elastic structure of the sarcomere. This stiffness increase may help in maintaining the sarcomere length uniformity under conditions of instability. PMID:14749216

  17. Learning to Control Arm Stiffness Under Static Conditions Mohammad Darainy,1,2

    E-print Network

    Malfait, Nicole

    Learning to Control Arm Stiffness Under Static Conditions Mohammad Darainy,1,2 Nicole Malfait,2 J. Ostry. Learning to control arm stiffness under static conditions. J Neurophysiol 92: 3344 the idea that impedance control involves a process of learning or adaptation that is acquired over time

  18. Dimensioning and Evaluation of the Elastic Element in a Variable Torsion Stiffness Actuator*

    E-print Network

    Stryk, Oskar von

    -- Variable stiffness joints are essential for robots or biomechanical applications to generate torque adjusting the stiffness is advantageous, since the natural frequency of the drive train and the frequency the physical structure the moment of inertia or the effective length can be altered. Another possibility

  19. Development of a Diaphragmatic Motion-Based Elastography Framework for Assessment of Liver Stiffness

    E-print Network

    Miga, Michael I.

    Development of a Diaphragmatic Motion-Based Elastography Framework for Assessment of Liver considerable promise for non-invasive assessment of liver stiffness to monitor hepatic fibrosis. MRE typically estimates of stiffness within the liver and surrounding tissue structures. We have previously developed

  20. Comparison of a manual and motorized stiffness meter to quantify bone regeneration in distraction osteogenesis.

    PubMed

    Thorey, Fritz; Floerkemeier, Thilo; Wellmann, Matthias; Windhagen, Henning

    2009-01-01

    To assess bone healing and investigate the influence of different pharmaceutics (e.g. growth factors) on bone stiffness and strength in-vivo, new quantitative methods are necessary. Therefore, a new manual and motorized stiffness meter to quantify bone regeneration in a model of distraction osteogenesis were compared. The design, equipment, and improvements of the measurement devices are described. Furthermore, their difference in precision and accuracy in comparison to tests from a material testing system, used as "gold standard", were evaluated. Both devices were able to assess regenerate stiffness: the accuracy ranged between +/- 9% for the manual and +/-5% for the motorized version for stiffness data over 0.1 Nm/ degrees; precision between +/- 3.8% for the manual and +/- 3.2% for the motorized device. In summary, the two stiffness measurement devices described in this study have the power to monitor the beginning of bone healing and therefore predict the load bearing capacity of regenerating bone. The motorized version showed advantages over the manual device when investigating and monitoring the stiffness of bone during a consolidation period: (1) better accuracy in both stiffness below and above 0.1 Nm/ degrees, (2) a better precision in the stiffness range of interest, (3) easier handling, and (4) standardisation of the measurement process using the stepper motor and definition of the maximums of torque, angulation and rotation speed. PMID:20051616

  1. DESIGN, FABRICATION AND EVALUATION OF NEGATIVE STIFFNESS ELEMENTS USING SELECTIVE LASER SINTERING*

    E-print Network

    Seepersad, Carolyn Conner

    1 DESIGN, FABRICATION AND EVALUATION OF NEGATIVE STIFFNESS ELEMENTS USING SELECTIVE LASER SINTERING is to leverage the geometric design freedoms provided by selective laser sintering (SLS) technology to design a broad range of tunable frequencies without compromising structural stiffness. Keywords: selective laser

  2. Multiple-input, multiple-output system identification for characterization of limb stiffness dynamics.

    PubMed

    Perreault, E J; Kirsch, R F; Acosta, A M

    1999-05-01

    This study presents time-domain and frequency-domain, multiple-input, multiple-output (MIMO) linear system identification techniques that can be used to estimate the dynamic endpoint stiffness of a multijoint limb. The stiffness of a joint or limb arises from a number of physiological mechanisms and is thought to play a fundamental role in the control of posture and movement. Estimates of endpoint stiffness can therefore be used to characterize its modulation during physiological tasks and may provide insight into how the nervous system normally controls motor behavior. Previous MIMO stiffness estimates have focused upon the static stiffness components only or assumed simple parametric models with elastic, viscous, and inertial components. The method presented here captures the full stiffness dynamics during a relatively short experimental trial while assuming only that the system is linear for small perturbations. Simulation studies were performed to investigate the performance of this approach under typical experimental conditions. It was found that a linear MIMO description of endpoint stiffness dynamics was sufficient to describe the displacement responses to small stochastic force perturbations. Distortion of these linear estimates by nonlinear centripetal and Coriolis forces was virtually undetectable for these perturbations. The system identification techniques were also found to be robust in the presence of significant output measurement noise and input coupling. These results indicate that the approach described here will allow the estimation of endpoint stiffness dynamics in an experimentally efficient manner with minimal assumptions about the specific form of these properties. PMID:10365425

  3. The effect of ankle foot orthosis stiffness on the energy cost of walking: A simulation study

    E-print Network

    Collins, Steven H.

    The effect of ankle foot orthosis stiffness on the energy cost of walking: A simulation study D of walking, spring-like carbon-composite Ankle Foot Orthoses are frequently prescribed. However, it is unknown what Ankle Foot Orthoses stiffness should be used to obtain the most efficient gait. The aim

  4. 2012 ASB Journal of Biomechanics Award Altering prosthetic foot stiffness influences foot and muscle

    E-print Network

    2012 ASB Journal of Biomechanics Award Altering prosthetic foot stiffness influences foot and releasing elastic energy during stance. However, how prosthetic foot stiffness influences muscle and foot foot prescription that may lead to improved amputee gait. The purpose of this study was to identify

  5. The effects of isometric and isotonic training on hamstring stiffness and anterior cruciate ligament loading mechanisms.

    PubMed

    Blackburn, J Troy; Norcross, Marc F

    2014-02-01

    Greater hamstring musculotendinous stiffness is associated with lesser ACL loading mechanisms. Stiffness is enhanced via training, but previous investigations evaluated tendon rather than musculotendinous stiffness, and none involved the hamstrings. We evaluated the effects of isometric and isotonic training on hamstring stiffness and ACL loading mechanisms. Thirty-six healthy volunteers were randomly assigned to isometric, isotonic, and control groups. Isometric and isotonic groups completed 6 weeks of training designed to enhance hamstring stiffness. Stiffness, anterior tibial translation, and landing biomechanics were measured prior to and following the interventions. Hamstring stiffness increased significantly with isometric training (15.7%; p=0.006), but not in the isotonic (13.5%; p=0.089) or control (0.4%; p=0.942) groups. ACL loading mechanisms changed in manners consistent with lesser loading, but these changes were not statistically significant. These findings suggest that isometric training may be an important addition to ACL injury prevention programs. The lack of significant changes in ACL loading mechanisms and effects of isotonic training were likely due to the small sample sizes per group and limited intervention duration. Future research using larger sample sizes and longer interventions is necessary to determine the effects of enhancing hamstring stiffness on ACL loading and injury risk. PMID:24268874

  6. DOI: 10.1002/adma.200700776 Ultrastrong, Stiff, and Lightweight Carbon-Nanotube Fibers**

    E-print Network

    Zhu, Yuntian T.

    DOI: 10.1002/adma.200700776 Ultrastrong, Stiff, and Lightweight Carbon-Nanotube Fibers** By Xiefei. Carbon nanotubes (CNTs) have extremely high strength,[2­5] very high stiffness,[6,7] low density, good very attractive for many structural applications and technologies. Here we report CNT fibers

  7. Running with a load increases leg stiffness Amy Silder a,n

    E-print Network

    Delp, Scott

    , and ankle flexion (po0.05). Our results reveal that subjects run in a more crouched posture and with higherRunning with a load increases leg stiffness Amy Silder a,n , Thor Besier c , Scott L. Delp a stiffness a b s t r a c t Spring-mass models have been used to characterize running mechanics and leg

  8. Wind Response Control of Building with Variable Stiffness Tuned Mass Damper Using Empirical Mode Decomposition

    E-print Network

    Nagarajaiah, Satish

    ; Stiffness; Buildings, high-rise; Australia. Introduction The effectiveness of tuned mass dampers TMDs Den is a proposed 76-story concrete office tower in Melbourne, Australia. It is a slender building 306 m tallWind Response Control of Building with Variable Stiffness Tuned Mass Damper Using Empirical Mode

  9. Face-Referenced Measurement of Perioral Stiffness and Speech Kinematics in Parkinson's Disease

    ERIC Educational Resources Information Center

    Chu, Shin Ying; Barlow, Steven M.; Lee, Jaehoon

    2015-01-01

    Purpose: Perioral biomechanics, labial kinematics, and associated electromyographic signals were sampled and characterized in individuals with Parkinson's disease (PD) as a function of medication state. Method: Passive perioral stiffness was sampled using the OroSTIFF system in 10 individuals with PD in a medication ON and a medication OFF state…

  10. Musculotendinous Stiffness of Triceps Surae, Maximal Rate of Force Development, and Vertical Jump Performance

    PubMed Central

    Driss, Tarak; Rouis, Majdi; Jaafar, Hamdi; Vandewalle, Henry

    2015-01-01

    The relationships between ankle plantar flexor musculotendinous stiffness (MTS) and performance in a countermovement vertical jump (CMJ) and maximal rate of torque development (MRTD) were studied in 27 active men. MTS was studied by means of quick releases at 20 (S0.2), 40 (S0.4), 60 (S0.6), and 80% (S0.8) of maximal voluntary torque (TMVC). CMJ was not correlated with strength indices but was positively correlated with MRTD/BM, S0.4/BM. The slope ?2 and intercept ?2 of the torque-stiffness relationships from 40 to 80% TMVC were correlated negatively (?2) and positively (?2) with CMJ. The different stiffness indices were not correlated with MRTD. The prediction of CMJ was improved by the introduction of MRTD in multiple regressions between CMJ and stiffness. CMJ was also negatively correlated with indices of curvature of the torque-stiffness relationship. The subjects were subdivided in 3 groups in function of CMJ (groups H, M, and L for high, medium, and low performers, resp.). There was a downward curvature of the torque-stiffness relationship at high torques in group H or M and the torque-stiffness regression was linear in group L only. These results suggested that torque-stiffness relationships with a plateau at high torques are more frequent in the best jumpers. PMID:25710026

  11. Extending Bell's Model: How Force Transducer Stiffness Alters Measured Unbinding Forces and Kinetics of Molecular Complexes

    E-print Network

    Van Vliet, Krystyn J.

    Extending Bell's Model: How Force Transducer Stiffness Alters Measured Unbinding Forces of the force transducer k can significantly perturb the energy landscape and the apparent unbinding force of the complex for sufficiently stiff force transducers. Additionally, at least 20% variation in unbinding force

  12. PolyMUMPs MEMS device to measure mechanical stiffness of single cells in aqueous media

    NASA Astrophysics Data System (ADS)

    Warnat, S.; King, H.; Forbrigger, C.; Hubbard, T.

    2015-02-01

    A method of experimentally determining the mechanical stiffness of single cells by using differential displacement measurements in a two stage spring system is presented. The spring system consists of a known MEMS reference spring and an unknown cellular stiffness: the ratio of displacements is related to the ratio of stiffness. A polyMUMPs implementation for aqueous media is presented and displacement measurements made from optical microphotographs using a FFT based displacement method with a repeatability of ~20?nm. The approach was first validated on a MEMS two stage spring system of known stiffness. The measured stiffness ratios of control structures (i) MEMS spring systems and (ii) polystyrene microspheres were found to agree with theoretical values. Mechanical tests were then performed on Saccharomyces cerevisiae (Baker’s yeast) in aqueous media. Cells were placed (using a micropipette) inside MEMS measuring structures and compressed between two jaws using an electrostatic actuator and displacements measured. Tested cells showed stiffness values between 5.4 and 8.4?N?m-1 with an uncertainty of 11%. In addition, non-viable cells were tested by exposing viable cells to methanol. The resultant mean cell stiffness dropped by factor of 3 × and an explicit discrimination between viable and non-viable cells based on mechanical stiffness was seen.

  13. Stiffness-Modulated Water Retention and Neovascularization of Dermal Fibroblast-Encapsulating Collagen Gel

    E-print Network

    Boppart, Stephen

    including skin. Introduction Many previous studies report that mechanical stiffness of a cell of certain stem and precursor cells to a specific lineage is maximized on a substrate with stiffness activities of cells surrounded by a three-dimensional (3D) matrix. These findings suggest that matrix

  14. Calculation of combined diffusion coefficients in SF{sub 6}-Cu mixtures

    SciTech Connect

    Zhong, Linlin; Wang, Xiaohua Rong, Mingzhe Wu, Yi; Murphy, Anthony B.

    2014-10-15

    Diffusion coefficients play an important role in the description of the transport of metal vapours in gas mixtures. This paper is devoted to the calculation of four combined diffusion coefficients, namely, the combined ordinary diffusion coefficient, combined electric field diffusion coefficient, combined temperature diffusion coefficient, and combined pressure diffusion coefficient in SF{sub 6}-Cu mixtures at temperatures up to 30?000?K. These four coefficients describe diffusion due to composition gradients, applied electric fields, temperature gradients, and pressure gradients, respectively. The influence of copper fluoride and sulfide species on the diffusion coefficients is shown to be negligible. The effect of copper proportion and gas pressures on these diffusion coefficients is investigated. It is shown that increasing the proportion of copper generally increases the magnitude of the four diffusion coefficients, except for copper mole fractions of 90% or more. It is further found that increasing the pressure reduces the magnitude of the coefficients, except for the combined temperature diffusion coefficient, and shifts the maximum of all four coefficients towards higher temperatures. The results presented in this paper can be applied to the simulation of high-voltage circuit breaker arcs.

  15. Apparent Linear Attenuation Coefficients in Phase Contrast X-Ray Tomography

    PubMed Central

    Yan, Aimin; Wu, Xizeng

    2011-01-01

    In the inline phase contrast x-ray tomography the reconstructed apparent linear attenuation coefficient values may be greatly larger than sample’s linear attenuation coefficients or even be negative. In this work we present a general formula to quantitatively relate the apparent linear attenuation coefficient values in cone-beam phase contrast tomography to sample’s linear attenuation coefficients and refractive indices. This formula overcomes the gross inaccuracy of the existing formula in the literature in analyzing high-resolution phase contrast tomography, and it will be useful for correctly interpreting and quantifying the apparent linear attenuation coefficients in cone-beam x-ray phase contrast tomography. PMID:21691420

  16. WAVE OF STIFFNESS PROPAGATING ALONG THE SURFACE OF THE NEWT EGG DURING CLEAVAGE

    PubMed Central

    Sawai, Tsuyoshi; Yoneda, Mitsuki

    1974-01-01

    In the eggs of the newt, Cynops (Triturus) pyrrhogaster, change in stiffness of the cortex was measured in various regions at the time of the cleavage. Measurements were performed by Mitchison and Swann's cell elastimeter method with a modification, in which two fine pipettes were attached to the surface of one egg at the same time, in order to compare the rigidity of two regions. The stiffness of the cortex changed very little before the start of the first cleavage. However, just before the appearance of the first cleavage furrow, the stiffness increased rapidly at the animal pole region, which later returned to the former level. As the cleavage furrow progressed, a wave of high stiffness travelled meridionally as a belt along the surface from the animal pole region toward the vegetal region. At second cleavage, the cycle of change in stiffness was repeated. PMID:4809240

  17. Single cell stiffness measurement at various humidity conditions by nanomanipulation of a nano-needle.

    PubMed

    Shen, Yajing; Nakajima, Masahiro; Yang, Zhan; Tajima, Hirotaka; Najdovski, Zoran; Homma, Michio; Fukuda, Toshio

    2013-04-12

    This paper presents a method for single cell stiffness measurement based on a nano-needle and nanomanipulation. The nano-needle with a buffering beam was fabricated from an atomic force microscope cantilever by the focused ion beam etching technique. Wild type yeast cells (W303) were prepared and placed on the sample stage inside an environmental scanning electron microscope (ESEM) chamber. The nanomanipulator actuated the nano-needle to press against a single yeast cell. As a result, the deformation of the cell and nano-needle was observed by the ESEM system in real-time. Finally, the stiffness of the single cell was determined based on this deformation information. To reveal the relationship between the cell stiffness and the environmental humidity conditions, the cell stiffness was measured at three different humidity conditions, i.e. 40, 70 and 100%, respectively. The results show that the stiffness of a single cell is reduced with increasing humidity. PMID:23507613

  18. QCT/FEA predictions of femoral stiffness are strongly affected by boundary condition modeling.

    PubMed

    Rossman, Timothy; Kushvaha, Vinod; Dragomir-Daescu, Dan

    2016-02-01

    Quantitative computed tomography-based finite element models of proximal femora must be validated with cadaveric experiments before using them to assess fracture risk in osteoporotic patients. During validation, it is essential to carefully assess whether the boundary condition (BC) modeling matches the experimental conditions. This study evaluated proximal femur stiffness results predicted by six different BC methods on a sample of 30 cadaveric femora and compared the predictions with experimental data. The average stiffness varied by 280% among the six BCs. Compared with experimental data, the predictions ranged from overestimating the average stiffness by 65% to underestimating it by 41%. In addition, we found that the BC that distributed the load to the contact surfaces similar to the expected contact mechanics predictions had the best agreement with experimental stiffness. We concluded that BC modeling introduced large variations in proximal femora stiffness predictions. PMID:25804260

  19. Running in the real world: adjusting leg stiffness for different surfaces.

    PubMed

    Ferris, D P; Louie, M; Farley, C T

    1998-06-01

    A running animal coordinates the actions of many muscles, tendons, and ligaments in its leg so that the overall leg behaves like a single mechanical spring during ground contact. Experimental observations have revealed that an animal's leg stiffness is independent of both speed and gravity level, suggesting that it is dictated by inherent musculoskeletal properties. However, if leg stiffness was invariant, the biomechanics of running (e.g. peak ground reaction force and ground contact time) would change when an animal encountered different surfaces in the natural world. We found that human runners adjust their leg stiffness to accommodate changes in surface stiffness, allowing them to maintain similar running mechanics on different surfaces. These results provide important insight into mechanics and control of animal locomotion and suggest that incorporating an adjustable leg stiffness in the design of hopping and running robots is important if they are to match the agility and speed of animals on varied terrain. PMID:9675909

  20. Running in the real world: adjusting leg stiffness for different surfaces

    NASA Technical Reports Server (NTRS)

    Ferris, D. P.; Louie, M.; Farley, C. T.

    1998-01-01

    A running animal coordinates the actions of many muscles, tendons, and ligaments in its leg so that the overall leg behaves like a single mechanical spring during ground contact. Experimental observations have revealed that an animal's leg stiffness is independent of both speed and gravity level, suggesting that it is dictated by inherent musculoskeletal properties. However, if leg stiffness was invariant, the biomechanics of running (e.g. peak ground reaction force and ground contact time) would change when an animal encountered different surfaces in the natural world. We found that human runners adjust their leg stiffness to accommodate changes in surface stiffness, allowing them to maintain similar running mechanics on different surfaces. These results provide important insight into mechanics and control of animal locomotion and suggest that incorporating an adjustable leg stiffness in the design of hopping and running robots is important if they are to match the agility and speed of animals on varied terrain.

  1. Hysteresis in the cell response to time-dependent substrate stiffness

    E-print Network

    Besser, A; 10.1016/j.bpj.2010.04.008

    2010-01-01

    Mechanical cues like the rigidity of the substrate are main determinants for the decision making of adherent cells. Here we use a mechano-chemical model to predict the cellular response to varying substrate stiffness. The model equations combine the mechanics of contractile actin filament bundles with a model for the Rho-signaling pathway triggered by forces at cell-matrix contacts. A bifurcation analysis of cellular contractility as a function of substrate stiffness reveals a bistable response, thus defining a lower threshold of stiffness, below which cells are not able to build up contractile forces, and an upper threshold of stiffness, above which cells are always in a strongly contracted state. Using the full dynamical model, we predict that rate-dependent hysteresis will occur in the cellular traction forces when cells are exposed to substrates of time-dependent stiffness.

  2. Development of a novel variable stiffness and damping magnetorheological fluid damper

    NASA Astrophysics Data System (ADS)

    Sun, Shuaishuai; Yang, Jian; Li, Weihua; Deng, Huaxia; Du, Haiping; Alici, Gursel

    2015-08-01

    This paper reports a novel magnetorheological fluid (MRF)-based damper, which synergizes the attributes of variable stiffness and damping through the compact assembly of two MRF damping units and a spring. The magnetic field densities of the two damping units were analyzed. After the prototype of the new MRF damper, a hydraulically actuated MTS machine was used to test the damper’s performance, including stiffness variability and damping variability, amplitude-dependent responses and frequency-dependent responses. A new mathematical model was developed to describe the variable stiffness and damping MRF damper. The successful development, experimental testing and modeling of this innovative variable stiffness and damping MRF damper make the true design and implementation of the concept of variable stiffness and damping feasible.

  3. Measurements of thermal accommodation coefficients.

    SciTech Connect

    Rader, Daniel John; Castaneda, Jaime N.; Torczynski, John Robert; Grasser, Thomas W.; Trott, Wayne Merle

    2005-10-01

    A previously-developed experimental facility has been used to determine gas-surface thermal accommodation coefficients from the pressure dependence of the heat flux between parallel plates of similar material but different surface finish. Heat flux between the plates is inferred from measurements of temperature drop between the plate surface and an adjacent temperature-controlled water bath. Thermal accommodation measurements were determined from the pressure dependence of the heat flux for a fixed plate separation. Measurements of argon and nitrogen in contact with standard machined (lathed) or polished 304 stainless steel plates are indistinguishable within experimental uncertainty. Thus, the accommodation coefficient of 304 stainless steel with nitrogen and argon is estimated to be 0.80 {+-} 0.02 and 0.87 {+-} 0.02, respectively, independent of the surface roughness within the range likely to be encountered in engineering practice. Measurements of the accommodation of helium showed a slight variation with 304 stainless steel surface roughness: 0.36 {+-} 0.02 for a standard machine finish and 0.40 {+-} 0.02 for a polished finish. Planned tests with carbon-nanotube-coated plates will be performed when 304 stainless-steel blanks have been successfully coated.

  4. A test apparatus and facility to identify the rotordynamic coefficients of high-speed hydrostatic bearings

    NASA Technical Reports Server (NTRS)

    Childs, Dara; Hale, Keith

    1994-01-01

    A facility and apparatus are described which determine stiffness, damping, and added-mass rotordynamic coefficients plus steady-state operating characteristics of high speed hydrostatic journal bearings. The apparatus has a current top speed of 29,800 rpm with a bearing diameter of 7.62 cm (3 in.). Purified warm water, 55 C (130 F), is used as a test fluid to achieve elevated Reynolds numbers during operation. The test-fluid pump yields a bearing maximum inlet pressure of 6.9 Mpa (1000 psi). Static load on the bearing is independently controlled and measured. Orthogonally mounted external shakers are used to excite the test stator in the direction of, and perpendicular to, the static load. The apparatus can independently calculate all rotordynamic coefficients at a given operating condition.

  5. Theory versus experiment for the rotordynamic coefficients of labyrinth gas seals. II - A comparison to experiment

    NASA Technical Reports Server (NTRS)

    Childs, D. W.; Scharrer, J. K.

    1987-01-01

    An experimental test facility is used to measure the leakage and rotordynamic coefficients of teeth-on-rotor and teeth-on-stator labyrinth gas seals. The test results are presented along with the theoretically predicted values for the two seal configurations at three different radial clearances and shaft speeds to 16,000 cpm. The test results show that the theory accurately predicts the cross-coupled stiffness for both seal configurations and shows improvement in the prediction of the direct damping for the teeth-on-rotor seal. The theory fails to predict a decrease in the direct damping coefficient for an increase in the radial clearance for the teeth-on-stator seal.

  6. A new method of measuring the stiffness of astronauts' EVA gloves

    NASA Astrophysics Data System (ADS)

    Mousavi, Mehdi; Appendino, Silvia; Battezzato, Alessandro; Bonanno, Alberto; Chen Chen, Fai; Crepaldi, Marco; Demarchi, Danilo; Favetto, Alain; Pescarmona, Francesco

    2014-04-01

    Hand fatigue is one of the most important problems of astronauts during their missions to space. This fatigue is due to the stiffness of the astronauts' gloves known as Extravehicular Activity (EVA) gloves. The EVA glove has a multilayered, bulky structure and is pressurized against the vacuum of space. In order to evaluate the stiffness of EVA gloves, different methods have been proposed in the past. In particular, the effects of wearing an EVA glove on the performance of the hands have been published by many researchers to represent the stiffness of the EVA glove. In this paper, a new method for measuring the stiffness of EVA gloves is proposed. A tendon-actuated finger probe is designed and used as an alternative to the human index finger in order to be placed inside an EVA glove and measure its stiffness. The finger probe is equipped with accelerometers, which work as tilt sensors, to measure the angles of its phalanges. The phalanges are actuated by applying different amount of torque using the tendons of the finger probe. Moreover, a hypobaric glove box is designed and realized to simulate the actual operating pressure of the EVA glove and to measure its stiffness in both pressurized and non-pressurized conditions. In order to prove the right performance of the proposed finger probe, an Orlam-DM EVA glove is used to perform a number of tests. The equation of stiffness for the PIP joint of this glove is extracted from the results acquired from the tests. This equation presents the torque required to flex the middle phalanx of the glove. Then, the effect of pressurization on the stiffness is highlighted in the last section. This setup can be used to measure the stiffness of different kinds of EVA gloves and allows direct, numerical comparison of their stiffness.

  7. Steady-state stiffness of utricular hair cells depends on macular location and hair bundle structure

    PubMed Central

    Spoon, Corrie; Moravec, W. J.; Rowe, M. H.; Grant, J. W.

    2011-01-01

    Spatial and temporal properties of head movement are encoded by vestibular hair cells in the inner ear. One of the most striking features of these receptors is the orderly structural variation in their mechanoreceptive hair bundles, but the functional significance of this diversity is poorly understood. We tested the hypothesis that hair bundle structure is a significant contributor to hair bundle mechanics by comparing structure and steady-state stiffness of 73 hair bundles at varying locations on the utricular macula. Our first major finding is that stiffness of utricular hair bundles varies systematically with macular locus. Stiffness values are highest in the striola, near the line of hair bundle polarity reversal, and decline exponentially toward the medial extrastriola. Striolar bundles are significantly more stiff than those in medial (median: 8.9 ?N/m) and lateral (2.0 ?N/m) extrastriolae. Within the striola, bundle stiffness is greatest in zone 2 (106.4 ?N/m), a band of type II hair cells, and significantly less in zone 3 (30.6 ?N/m), which contains the only type I hair cells in the macula. Bathing bundles in media that break interciliary links produced changes in bundle stiffness with predictable time course and magnitude, suggesting that links were intact in our standard media and contributed normally to bundle stiffness during measurements. Our second major finding is that bundle structure is a significant predictor of steady-state stiffness: the heights of kinocilia and the tallest stereocilia are the most important determinants of bundle stiffness. Our results suggest 1) a functional interpretation of bundle height variability in vertebrate vestibular organs, 2) a role for the striola in detecting onset of head movement, and 3) the hypothesis that differences in bundle stiffness contribute to diversity in afferent response dynamics. PMID:21918003

  8. Leg stiffness during phases of countermovement and take-off in vertical jump.

    PubMed

    Struzik, Artur; Zawadzki, Jerzy

    2013-01-01

    With respect to cyclic movements such as human gait, running or hopping, leg stiffness is a little variable parameter. The aim of this study was to investigate changes in leg stiffness during the phase of countermovement and take-off when performing a single maximum counter-movement jump. Kistler force plates and a BTS SMART system for comprehensive motion analysis were employed in the study. The study covered a group of 12 athletes from university basketball teams. Leg stiffness was calculated in those parts of countermovement and take-off phases where its level is relatively constant and the relationship F(?l) is similar to linear one. Mean total stiffness (±SD) in both legs in the countermovement phase amounted to 6.5 ± 1.5 kN/m, whereas during the take-off phase this value was 6.9 ± 1 kN/m. No statistically significant differences were found between leg stiffness during the countermovement phase and takeoff phase in the study group at the level of significance set at ? = 0.05. This suggests that the leg stiffness in phase of countermovement and phase of take-off are much similar to each other, despite different function of both phases. Similar to cyclic movements, leg stiffness turned out relatively constant when performing a single vertical jump. There are also reported statistically significant correlations between body mass, body height, length of lower limbs and leg stiffness. The stiffness analysed by the authors should be understood as quasi-stiffness because the measurements of ?F(?l) were made during transient states where inertia and dumping forces are likely to affect the final result. PMID:23952196

  9. Off-fault shear failure potential enhanced by high-stiff/low-permeable damage zone during fluid injection in porous reservoirs

    NASA Astrophysics Data System (ADS)

    Rohmer, J.; Nguyen, T. K.; Torabi, A.

    2015-09-01

    Several studies have focused on the role of damage zone (DZ) on the hydromechanical behaviour of faults by assuming a fractured DZ (i.e. low stiffness/high permeability). Yet, this vision may not be valid in all geological settings, in particular, in high-porosity reservoirs as targeted by several underground exploitations. We investigate the impact of a high-stiff/low-permeable DZ on the shear reactivation of a blind, undetectable normal fault (1 km long, ?10 m offset), with a 0.5 m thick low-porosity/permeability fault core during fluid injection into a high-porosity reservoir. The spatial distribution of effective properties (elastic moduli, Biot's coefficients and permeability) of DZ including deformation bands (DB; elliptic inclusions) and intact rock were derived using upscaling analytical expressions. The influence of DZ on the hydromechanical behaviour of the fault zone was numerically explored using 2-D plane-strain finite-element simulations within the framework of fully saturated isothermal porous media by accounting for an orthotropic elastic rheology. The numerical results showed that the presence of DB plays a protective role by reducing the potential for shear reactivation inside the fault core. On the other hand, they favour shear failure in the vicinity of the fault core (off-fault damage) by accelerating the decrease of the minimum principal effective stress while limiting the decrease of the maximum one. This behaviour is strongly enhanced by the fault-parallel DZ effective stiffness, but limited by the combined effect of fault-normal DZ effective permeability and of the Biot's coefficients. This can have implications for the location and size of aftershocks during fault reactivation.

  10. The theoretical ultimate magnetoelectric coefficients of magnetoelectric composites by optimization design

    SciTech Connect

    Wang, H.-L.; Liu, B.

    2014-03-21

    This paper investigates what is the largest magnetoelectric (ME) coefficient of ME composites, and how to realize it. From the standpoint of energy conservation, a theoretical analysis is carried out on an imaginary lever structure consisting of a magnetostrictive phase, a piezoelectric phase, and a rigid lever. This structure is a generalization of various composite layouts for optimization on ME effect. The predicted theoretical ultimate ME coefficient plays a similar role as the efficiency of ideal heat engine in thermodynamics, and is used to evaluate the existing typical ME layouts, such as the parallel sandwiched layout and the serial layout. These two typical layouts exhibit ME coefficient much lower than the theoretical largest values, because in the general analysis the stress amplification ratio and the volume ratio can be optimized independently and freely, but in typical layouts they are dependent or fixed. To overcome this shortcoming and achieve the theoretical largest ME coefficient, a new design is presented. In addition, it is found that the most commonly used electric field ME coefficient can be designed to be infinitely large. We doubt the validity of this coefficient as a reasonable ME effect index and consider three more ME coefficients, namely the electric charge ME coefficient, the voltage ME coefficient, and the static electric energy ME coefficient. We note that the theoretical ultimate value of the static electric energy ME coefficient is finite and might be a more proper measure of ME effect.

  11. The emission coefficient of uranium plasmas

    NASA Technical Reports Server (NTRS)

    Schneider, R. T.; Campbell, H. D.; Mack, J. M.

    1973-01-01

    The emission coefficient for uranium plasmas (Temperature: 8000 K) was measured for the wavelength range (200 A - 6000 A). The results are compared to theory and other measurements. The absorption coefficient for the same wavelength interval is also given.

  12. Absolute measurement of cerebral optical coefficients, hemoglobin

    E-print Network

    Fantini, Sergio

    Absolute measurement of cerebral optical coefficients, hemoglobin concentration and oxygen Aron M. Troen Sergio Fantini #12;Absolute measurement of cerebral optical coefficients, hemoglobin-infrared spectroscopy measurement of absolute cerebral hemoglobin concentration and saturation in a large sample of 36

  13. The number of nonzero binomial coefficients modulo p^alpha

    E-print Network

    Rowland, Eric S

    2010-01-01

    In 1947 Fine obtained an expression for the number a_p(n) of binomial coefficients on row n of Pascal's triangle that are nonzero modulo p. One can set up a recurrence for the number of integers 0 theorem renders this recurrence as a generalization of Fine's theorem, giving a way to compute the number a_{p^alpha}(n) of nonzero binomial coefficients modulo p^alpha. From the recurrence we obtain an expression for a_{p^alpha}(n) in terms of the number of occurrences of various words in the base-p representation of n.

  14. Heat transfer coefficients of dilute flowing gas-solids suspensions

    NASA Technical Reports Server (NTRS)

    Kane, R. S.; Pfeffer, R.

    1973-01-01

    Heat transfer coefficients of air-glass, argon-glass, and argon-aluminum suspensions were measured in horizontal and vertical tubes. The glass, 21.6 and 36.0 micron diameter particles, was suspended at gas Reynolds numbers between 11,000 and 21,000 and loading ratios between 0 and 2.5. The presence of particles generally reduced the heat transfer coefficient. The circulation of aluminum powder in the 0.870 inch diameter closed loop system produced tenacious deposits on protuberances into the stream. In the vertical test section, the Nusselt number reduction was attributed to viscous sublayer thickening; in the horizontal test section to particle deposition.

  15. Creating materials with a desired refraction coefficient

    E-print Network

    A. G. Ramm

    2009-09-02

    A method is given for creating material with a desired refraction coefficient. The method consists of embedding into a material with known refraction coefficient many small particles of size $a$. The number of particles per unit volume around any point is prescribed, the distance between neighboring particles is $O(a^{\\frac{2-\\kappa}{3}})$ as $a\\to 0$, $0refraction coefficient is the coefficient $n^2(x)$ in the wave equation $[\

  16. A Comparison of Stiff ODE Solvers for Astrochemical Kinetics Problems

    NASA Astrophysics Data System (ADS)

    Nejad, Lida A. M.

    2005-09-01

    The time dependent chemical rate equations arising from astrochemical kinetics problems are described by a system of stiff ordinary differential equations (ODEs). In this paper, using three astrochemical models of varying physical and computational complexity, and hence different degrees of stiffness, we present a comprehensive performance survey of a set of well-established ODE solver packages from the ODEPACK collection, namely LSODE, LSODES, VODE and VODPK. For completeness, we include results from the GEAR package in one of the test models. The results demonstrate that significant performance improvements can be obtained over GEAR which is still being used by many astrochemists by default. We show that a simple appropriate ordering of the species set results in a substantial improvement in the performance of the tested ODE solvers. The sparsity of the associated Jacobian matrix can be exploited and results using the sparse direct solver routine LSODES show an extensive reduction in CPU time without any loss in accuracy. We compare the performance and the computed abundances of one model with a 175 species set and a reduced set of 88 species, keeping all physical and chemical parameters identical with both sets.We found that the calculated abundances using two different size models agree quite well. However, with no extra computational effort and more reliable results, it is possible for the computation to be many times faster with the larger species set than the reduced set, depending on the use of solvers, the ordering and the chosen options. It is also shown that though a particular solver with certain chosen parameters may have severe difficulty or even fail to complete a run over the required integration time, another solver can easily complete the run with a wider range of control parameters and options. As a result of the superior performance of LSODES for the solution of astrochemical kinetics systems, we have tailor-made a sparse version of the VODE solver by replacing the full numerical matrix linear algebra component of the standard VODE solver with sparse matrix solver routines. The preliminary tests from the preconditioned iterative solver package VODPK indicate very good results for one of our test models, but not for all of the models.

  17. Characteristic magnitude of subduction earthquake and upper plate stiffness

    NASA Astrophysics Data System (ADS)

    Sakaguchi, A.; Yamamoto, Y.; Hashimoto, Y.; Harris, R. N.; Vannucchi, P.; Petronotis, K. E.

    2013-12-01

    Variations in earthquake magnitude and recurrence intervals of fault behavior are best understood in the context of regional tectonics. Convergent margins may be divided into two end-member types termed erosive and accretionary plate boundaries (e.g. von Huene and Scholl, 1991; Clift and Vannucchi, 2004). These margins often differ greatly in in lithology, physical properties and thermal conditions. The Nankai accretionary margin has a 1300-year historical earthquake record with a recurrence interval of 100-150 years (Ando, 1975). Great earthquakes at Nankai are typically tsunamigenic and include the 1944 Tonankai (Mw=8.1) and 1946 Nankaido (Mw=8.1) earthquakes (Kanamori, 1977). In contrast, the Middle America trench offshore Costa Rica events of M=7.6 reoccur on average of every 40 years. Comparisons between these margins may produce insights into mechanisms that influence characteristic magnitudes and recurrence intervals of subduction earthquakes. The IODP Costa-Rica Seismogenesis Program (CRISP) has carried out the first step toward the deep riser drilling by characterizing the shallow lithologic, hydrologic, stress, and thermal state at offshore Osa Peninsula (Vannucchi et al., 2011; Harris et al., 2013). CRISP drilling reveals that the shallow basement of upper plate crust is forearc basin material consisting of lithic sedimentary units with terrigenous sediment accumulated at a high rate. A large sediment flux to the forearc may have originated from the uplifted back-arc Talamanca Cordillera due to Cocos-Ridge subduction (Lonsdale and Klitgord, 1978; van Andel et al., 1971). Both drilling area of the Nankai and Costa-Rica, off Osa are characterized by the subduction of young oceanic crust with high heat flow and active fluid flow (Spinelli and Wang, 2008; Spinelli and Harris, 2011; Harris et al., 2010). The P-wave velocity structure shows that upper plate body of Costa Rica is much more lithified than the Nankai margin. In frictional stick-slip system, the recurrence interval and event displacement varies with the stiffness of the system. We propose that an important factor influencing the characteristic magnitude of large subduction earthquakes and recurrence intervals is stiffness of the upper plate. This model predicts that event displacement, and thus magnitude, is smaller at Costa Rica than at Nankai because the upper plate is stiffer at Costa Rica. This hypothesis can be tested based on elastic parameters estimated from seismic data and physical properties of core samples obtained from deep drilling.

  18. Ratios of internal conversion coefficients

    SciTech Connect

    Raman, S.; Ertugrul, M.; Nestor, C.W. . E-mail: CNestorjr@aol.com; Trzhaskovskaya, M.B.

    2006-03-15

    We present here a database of available experimental ratios of internal conversion coefficients for different atomic subshells measured with an accuracy of 10% or better for a number of elements in the range 26 {<=} Z {<=} 100. The experimental set involves 414 ratios for pure and 1096 ratios for mixed-multipolarity nuclear transitions in the transition energy range from 2 to 2300 keV. We give relevant theoretical ratios calculated in the framework of the Dirac-Fock method with and without regard for the hole in the atomic subshell after conversion. For comparison, the ratios obtained within the relativistic Hartree-Fock-Slater approximation are also presented. In cases where several ratios were measured for the same transition in a given isotope in which two multipolarities were involved, we present the mixing ratio {delta} {sup 2} obtained by a least squares fit.

  19. Soccer Ball Lift Coefficients via Trajectory Analysis

    ERIC Educational Resources Information Center

    Goff, John Eric; Carre, Matt J.

    2010-01-01

    We performed experiments in which a soccer ball was launched from a machine while two high-speed cameras recorded portions of the trajectory. Using the trajectory data and published drag coefficients, we extracted lift coefficients for a soccer ball. We determined lift coefficients for a wide range of spin parameters, including several spin…

  20. Standards for Standardized Logistic Regression Coefficients

    ERIC Educational Resources Information Center

    Menard, Scott

    2011-01-01

    Standardized coefficients in logistic regression analysis have the same utility as standardized coefficients in linear regression analysis. Although there has been no consensus on the best way to construct standardized logistic regression coefficients, there is now sufficient evidence to suggest a single best approach to the construction of a…

  1. widehat {su}( 3 ; )k FUSION COEFFICIENTS

    NASA Astrophysics Data System (ADS)

    Bégin, L.; Mathieu, P.; Walton, M. A.

    A closed and explicit formula for all widehat {su}( 3 ; )k fusion coefficients is presented which, in the limit k??, turns into a simple and compact expression for the su(3) tensor product coefficients. The derivation is based on a new diagrammatic method which gives directly both tensor product and fusion coefficients.

  2. M-Bonomial Coefficients and Their Identities

    ERIC Educational Resources Information Center

    Asiru, Muniru A.

    2010-01-01

    In this note, we introduce M-bonomial coefficients or (M-bonacci binomial coefficients). These are similar to the binomial and the Fibonomial (or Fibonacci-binomial) coefficients and can be displayed in a triangle similar to Pascal's triangle from which some identities become obvious.

  3. Reliability Generalization: "Lapsus Linguae"

    ERIC Educational Resources Information Center

    Smith, Julie M.

    2011-01-01

    This study examines the proposed Reliability Generalization (RG) method for studying reliability. RG employs the application of meta-analytic techniques similar to those used in validity generalization studies to examine reliability coefficients. This study explains why RG does not provide a proper research method for the study of reliability,…

  4. Stiffness map of the grasping contact areas of the human hand.

    PubMed

    Pérez-González, Antonio; Vergara, Margarita; Sancho-Bru, Joaquin L

    2013-10-18

    The elasticity and damping of the soft tissues of the hand contribute to dexterity while grasping and also help to stabilise the objects in manipulation tasks. Although some previous works have studied the force-displacement response of the fingertips, the responses in all other regions of the hand that usually participate in grasping have not been analysed to date. In this work we performed experimental measurements in 20 subjects to obtain a stiffness map of the different grasping contact areas of the human hand. A force-displacement apparatus was used to simultaneously measure force and displacement at 39 different points on the hand at six levels of force ranging from 1N to 6N. A non-linear force-displacement response was found for all points, with stiffness increasing with the amount of force applied. Mean stiffness for the different points and force levels was within the range from 0.2N/mm to 7.7N/mm. However, the stiffness range and variation with level of force were found to be different from point to point. A total of 13 regions with similar stiffness behaviours were identified. The stiffness in the fingertips increased linearly with the amount of force applied, while in the palm it remained more constant for the range of forces considered. It is hypothesised that the differences in the stiffness behaviour from one region to another allow these regions to play different roles during grasping. PMID:24063886

  5. The leg stiffnesses animals use may improve the stability of locomotion.

    PubMed

    Shen, ZhuoHua; Seipel, Justin

    2015-07-21

    Despite a wide diversity of running animals, their leg stiffness normalized by animal size and weight (a relative leg stiffness) resides in a narrow range between 7 and 27. Here we determine if the stability of locomotion could be a driving factor for the tight distribution of animal leg stiffness. We simulated an established physics-based model (the actuated Spring-Loaded Inverted Pendulum model) of animal running and found that, with the same energetic cost, perturbations to locomotion are optimally corrected when relative leg stiffness is within the biologically observed range. Here we show that the stability of locomotion, in combination with energetic cost, could be a significant factor influencing the nearly universally observed animal relative leg stiffness range. The energetic cost of locomotion has been widely acknowledged as influencing the evolution of physiology and locomotion behaviors. Specifically, its potential importance for relative leg stiffness has been demonstrated. Here, we demonstrate that stability of locomotion may also be a significant factor influencing relative leg stiffness. PMID:25908205

  6. In vivo and in vitro measurements of pulmonary arterial stiffness: A brief review

    PubMed Central

    Tian, Lian; Chesler, Naomi C.

    2012-01-01

    During the progression of pulmonary hypertension (PH), proximal pulmonary arteries (PAs) undergo remodeling such that they become thicker and the elastic modulus increases. Both of these changes increase the vascular stiffness. The increase in pulmonary vascular stiffness contributes to increased right ventricular (RV) afterload, which causes RV hypertrophy and eventually failure. Studies have found that proximal PA stiffness or its inverse, compliance, is strongly related to morbidity and mortality in patients with PH. Therefore, accurate in vivo measurement of PA stiffness is useful for prognoses in patients with PH. It is also important to understand the structural changes in PAs that occur with PH that are responsible for stiffening. Here, we briefly review the most common parameters used to quantify stiffness and in vivo and in vitro methods for measuring PA stiffness in human and animal models. For in vivo approaches, we review invasive and noninvasive approaches that are based on measurements of pressure and inner or outer diameter or cross-sectional area. For in vitro techniques, we review several different testing methods that mimic one, two or several aspects of physiological loading (e.g., uniaxial and biaxial testing, dynamic inflation-force testing). Many in vivo and in vitro measurement methods exist in the literature, and it is important to carefully choose an appropriate method to measure PA stiffness accurately. Therefore, advantages and disadvantages of each approach are discussed. PMID:23372936

  7. The influence of ankle-foot orthosis stiffness on walking performance in individuals with lower-limb impairments

    E-print Network

    The influence of ankle-foot orthosis stiffness on walking performance in individuals with lower-dynamic ankle-foot orthoses utilize stiffness to improve gait performance through elastic energy storage and return. However, the influence of ankle-foot orthosis stiffness on gait performance has not been

  8. The influence of energy storage and return foot stiffness on walking mechanics and muscle activity in below-knee amputees

    E-print Network

    The influence of energy storage and return foot stiffness on walking mechanics and muscle activity the influence of foot stiffness on kinematics, kinetics, muscle activity, prosthetic energy storage and return: As stiffness decreased, peak residual and intact leg ankle angles and residual leg knee flexion angle increased

  9. Cytoskeletal prestress regulates nuclear shape and stiffness in cardiac myocytes.

    PubMed

    Lee, Hyungsuk; Adams, William J; Alford, Patrick W; McCain, Megan L; Feinberg, Adam W; Sheehy, Sean P; Goss, Josue A; Parker, Kevin Kit

    2015-11-01

    Mechanical stresses on the myocyte nucleus have been associated with several diseases and potentially transduce mechanical stimuli into cellular responses. Although a number of physical links between the nuclear envelope and cytoplasmic filaments have been identified, previous studies have focused on the mechanical properties of individual components of the nucleus, such as the nuclear envelope and lamin network. The mechanical interaction between the cytoskeleton and chromatin on nuclear deformability remains elusive. Here, we investigated how cytoskeletal and chromatin structures influence nuclear mechanics in cardiac myocytes. Rapid decondensation of chromatin and rupture of the nuclear membrane caused a sudden expansion of DNA, a consequence of prestress exerted on the nucleus. To characterize the prestress exerted on the nucleus, we measured the shape and the stiffness of isolated nuclei and nuclei in living myocytes during disruption of cytoskeletal, myofibrillar, and chromatin structure. We found that the nucleus in myocytes is subject to both tensional and compressional prestress and its deformability is determined by a balance of those opposing forces. By developing a computational model of the prestressed nucleus, we showed that cytoskeletal and chromatin prestresses create vulnerability in the nuclear envelope. Our studies suggest the cytoskeletal-nuclear-chromatin interconnectivity may play an important role in mechanics of myocyte contraction and in the development of laminopathies by lamin mutations. PMID:25908635

  10. Shape memory polymer hexachiral auxetic structures with tunable stiffness

    NASA Astrophysics Data System (ADS)

    Rossiter, Jonathan; Takashima, Kazuto; Scarpa, Fabrizio; Walters, Peter; Mukai, Toshiharu

    2014-04-01

    Planar auxetic structures have the potential to impact on a wide range of applications from deployable and morphing structures to space-filling composite and medical treatments. The ability to fabricate auxetics from smart materials greatly enhances this facility by building in controllable actuation and deployment. A smart auxetic device can be compressed and fixed into a storage state. When deployment is required the device can be appropriately stimulated and the stored elastic energy is released, resulting in a marked structural expansion. Instead of using a conventional external actuator to drive deployment the material is made to undergo phase transition where one stimulus (e.g. heat) initiates a mechanical response. Here we show how smart material auxetics can be realized using a thermally responsive shape memory polymer composites. We show how a shape memory polymer auxetic hexachiral structure can be tailored to provide a tunable stiffness response in its fully deployed state by varying the angle of inter-hub connections, and yet is still able to undergo thermally stimulated deployment.

  11. Modulating surface stiffness of polydimethylsiloxane (PDMS) with kiloelectronvolt ion patterning

    NASA Astrophysics Data System (ADS)

    Liu, Boyin; Fu, Jing

    2015-06-01

    This study is to investigate the modulated surface properties of polydimethylsiloxane (PDMS) with kiloelectronvolt ions. By irradiating the PDMS surface with a focused ion beam (FIB, keV Ga+), nano/microscale patterns of controlled stiffness can be fabricated with ion fluence ranging from 0.1-20?pC?µm-2. The following nanoindentation measurements with an atomic force microscope (AFM) revealed that Young’s modulus increased exponentially with the increase of ion fluence and reached 2?GPa. The stiffening was found to be less significant with irradiation at a higher ion incident angle and lower accelerating voltage. Raman spectroscopy results also confirmed that disordering caused by cross-linking and hydrogen release occurred on the target PDMS surface. By modelling and experimenting on PDMS-Si3N4 bilayer structures, the volume reduction ratios of PDMS with ion beam and electron beam irradiation were estimated. The proposed site specific modulating method and understanding of detailed governing mechanisms will allow the tuning of the PDMS surface with great accuracy and flexibility towards future applications in tissue engineering and microfabrication.

  12. Umbilical Stiffness Matrix Characterization and Testing for Microgravity Science Payloads

    NASA Technical Reports Server (NTRS)

    Engberg, Robert C.

    2003-01-01

    This paper describes efforts of testing and analysis of various candidate cables and umbilicals for International Space Station microgravity science payloads. The effects of looping, large vs. small displacements, and umbilical mounting configurations were assessed. A 3-DOF stepper motor driven fixture was used to excite the umbilicals. Forces and moments were directly measured in all three axes with a 6-DOF load cell in order to derive suitable stiffness matrices for design and analysis of vibration isolation controllers. Data obtained from these tests were used to help determine the optimum type and configuration of umbilical cables for the International Space Station microgravity science glovebox (MSG) vibration isolation platform. The data and procedures can also be implemented into control algorithm simulations to assist in validation of actively controlled vibration isolation systems. The experimental results of this work are specific in support of the Glovebox Integrated Microgravity Isolation Technology (g-LIMIT) isolation platform, to be located in the microgravity science glovebox aboard the U.S. Destiny Laboratory Module.

  13. A Case of Stiff Person Syndrome: Immunomodulatory Effect of Benzodiazepines

    PubMed Central

    Zdziarski, Przemyslaw

    2015-01-01

    Abstract Stiff person syndrome (SPS) is a rare autoimmune disease. Most patients have high-titer antibodies against glutamate decarboxylase (GADAb), which is without practical value in disease monitoring. Benzodiazepines are the first line drugs, but long-term use is not well characterized. This report demonstrates ineffective benzodiazepine therapy of SPS that prompts tachyphylaxis, loss of responsiveness, and finally benzodiazepine withdrawal syndrome. Convulsion and anxiety correlate with high level of creatine phosphokinase (CK). Although tonus and spasm attacks were successfully controlled by tizanidine, glutamate release inhibitor, the immune response, and autoimmune diabetes development require the plasmapheresis, mycophenolat mofetil, and rituximab therapy that results in a significant decrease of GADAb, impaired glucose tolerance (IGT), lactate dehydrogenase (LDH), and CK normalization. Unfortunately, reintroduction of benzodiazepine was a source of rapid and high increase of CK, LDH, GADAb titer (up to 1:15,000), IGT, and SPS relapse. Contrary to previous publications, we observed IGT that correlated with high anti-GAD level, but without high immunogenetic susceptibility to haplotype human leukocyte antigens-DR3, DQw2. This preliminary observation and the last finding of immunomodulatory properties of peripheral benzodiazepine receptor suggest that increased antigenic stimulation during benzodiazepine therapy and glutamatergic hyperactivity could account for convulsions observed in SPS. Benzodiazepine withdrawal prompted alternative muscle relaxant therapy (tizanidine). Muscular and brain abnormalities observed in SPS indicate that noncardiac CK level may be a useful tool in SPS therapy monitoring. PMID:26061327

  14. Resisting sarcolemmal rupture: dystrophin repeats increase membrane-actin stiffness.

    PubMed

    Sarkis, Joe; Vié, Véronique; Winder, Steve J; Renault, Anne; Le Rumeur, Elisabeth; Hubert, Jean-François

    2013-01-01

    Dystrophin is an essential part of a membrane protein complex that provides flexible support to muscle fiber membranes. Loss of dystrophin function leads to membrane fragility and muscle-wasting disease. Given the importance of cytoskeletal interactions in strengthening the sarcolemma, we have focused on actin-binding domain 2 of human dystrophin, constituted by repeats 11 to 15 of the central domain (DYS R11-15). We previously showed that DYS R11-15 also interacts with membrane lipids. We investigated the shear elastic constant (?) and the surface viscosity (?(s)) of Langmuir phospholipid monolayers mimicking the inner leaflet of the sarcolemma in the presence of DYS R11-15 and actin. The initial interaction of 100 nM DYS R11-15 with the monolayers slightly modifies their rheological properties. Injection of 0.125 ?M filamentous actin leads to a strong increase of ? and ?(s,) from 0 to 5.5 mN/m and 2.4 × 10(-4) N · s/m, respectively. These effects are specific to DYS R11-15, require filamentous actin, and depend on phospholipid nature and lateral surface pressure. These findings suggest that the central domain of dystrophin contributes significantly to the stiffness and the stability of the sarcolemma through its simultaneous interactions with the cytoskeleton and lipid membrane. This mechanical link is likely to be a major contributing factor to the shock absorber function of dystrophin and muscle sarcolemmal integrity on mechanical stress. PMID:23033320

  15. On-machine ultrasonic sensors for paper stiffness. Final report

    SciTech Connect

    Hall, Maclin S.; Jackson, Theodore G.; Brown, Ernest

    2000-04-01

    This final report presents the results of a 5-year effort by the Institute of Paper Science and Technology (IPST) and its participating partners. The objective of this work was to develop and demonstrate sensors capable of measuring the velocity of ultrasound in the out-of-plane (ZD) and in-plane directions of paper as it is being produced on a commercial paper machine. On-machine ultrasonic measurements can be used to determine various mechanical properties of paper and to monitor process status and product quality. This report first presents a review of the background and potential benefits of on-machine ultrasonic measurements, then summarizes the results of previous work. The ZD measurement system involving the use of ultrasonic transducers in fluid-filled wheels is described in detail, including the method of measurement, the wheel mounting hardware, the on-machine operation, and an overview of the system software. Mill-trial results from two bump tests when producing 69{number_sign} and 55{number_sign} linearboard are presented. For the 69{number_sign} trial the correlation of ZD transit time with plybond and with ZDT (Z-direction tensile or internal bond strength) was greater than 0.8 (R squared). Also observed were ZD stiffness responses to refining and to calendering. ABB Industrial Systems Inc. was responsible for the in-plane sensor. A paper describing ABB's sensor and mill experience is appended.

  16. Probing DNA Stiffness through Optical Fluctuation Analysis of Plasmon Rulers.

    PubMed

    Chen, Tianhong; Hong, Yan; Reinhard, Björn M

    2015-08-12

    The distance-dependent plasmon coupling between biopolymer tethered gold or silver nanoparticles forms the foundation for the so-called plasmon rulers. While conventional plasmon ruler applications focus on the detection of singular events in the far-field spectrum, we perform in this Letter a ratiometric analysis of the continuous spectral fluctuations arising from thermal interparticle separation variations in plasmon rulers confined to fluid lipid membranes. We characterized plasmon rulers with different DNA tethers and demonstrate the ability to detect and quantify differences in the plasmon ruler potential and tether stiffness. The influence of the nature of the tether (single-stranded versus double-stranded DNA) and the length of the tether is analyzed. The characterization of the continuous variation of the interparticle separation in individual plasmon rulers through optical fluctuation analysis provides additional information about the conformational flexibility of the tether molecule(s) located in the confinement of the deeply subdiffraction limit interparticle gap and enhances the versatility of plasmon rulers as a tool in Biophysics and Nanotechnology. PMID:26121062

  17. Finger stiffness or edema as presenting symptoms of eosinophilic fasciitis.

    PubMed

    Suzuki, Shingo; Noda, Kazutaka; Ohira, Yoshiyuki; Shikino, Kiyoshi; Ikusaka, Masatomi

    2015-10-01

    To investigate the clinical features and finger symptoms of eosinophilic fasciitis (EF), we reviewed five patients with EF. The chief complaint was pain, edema and/or stiffness of the extremities. The distal extremities were affected in all patients, and there was also proximal involvement in one patient. One patient had asymmetrical symptoms. All four patients with upper limb involvement had limited range of motion of the wrist joints, and three of them complained of finger symptoms. Two of these three patients showed slight non-pitting edema of the hands, and the other one had subcutaneous induration of the forearm. All four patients with lower limb symptoms had limited range of motion of the ankle joints, and two showed edema or induration of the legs. Inflammatory changes in the joints were not detected in any of the patients. Two patients displayed neither objective induration nor edema, and two patients had muscle tenderness. In conclusion, finger symptoms of patients with EF might be caused by fasciitis of the forearms, which leads to dysfunction of the long finger flexors and extensors as well as slight edema of hands. Limited range of motion of wrist and/or ankle joints indicates sensitively distal muscle dysfunction caused by fasciitis. PMID:26248532

  18. The gearing function of running shoe longitudinal bending stiffness.

    PubMed

    Willwacher, Steffen; König, Manuel; Braunstein, Björn; Goldmann, Jan-Peter; Brüggemann, Gert-Peter

    2014-07-01

    The purpose of the present study was to investigate whether altered longitudinal bending stiffness (LBS) levels of the midsole of a running shoe lead to a systematic change in lower extremity joint lever arms of the ground reaction force (GRF). Joint moments and GRF lever arms in the sagittal plane were determined from 19 male subjects running at 3.5 m/s using inverse dynamics procedures. LBS was manipulated using carbon fiber insoles of 1.9 mm and 3.2 mm thickness. Increasing LBS led to a significant shift of joint lever arms to a more anterior position. Effects were more pronounced at distal joints. Ankle joint moments were not significantly increased in the presence of higher GRF lever arms when averaged over all subjects. Still, two individual strategies (1: increase ankle joint moments while keeping push-off times almost constant, 2: decrease ankle joint moments and increase push-off times) could be identified in response to increased ankle joint lever arms that might reflect individual differences between subjects with respect to strength capacities or anthropometric characteristics. The results of the present study indicate that LBS systematically influences GRF lever arms of lower extremity joints during the push-off phase in running. Further, individual responses to altered LBS levels could be identified that could aid in finding optimum LBS values for a given individual. PMID:24882222

  19. Spectrin Folding versus Unfolding Reactions and RBC Membrane Stiffness

    PubMed Central

    Zhu, Qiang; Asaro, Robert J.

    2008-01-01

    Spectrin (Sp), a key component of the erythrocyte membrane, is routinely stretched to near its fully folded contour length during cell deformations. Such dynamic loading may induce domain unfolding as suggested by recent experiments. Herein we develop a model to describe the folding/unfolding of spectrin during equilibrium or nonequilibrium extensions. In both cases, our model indicates that there exists a critical extension beyond which unfolding occurs. We further deploy this model, together with a three-dimensional model of the junctional complex in the erythrocyte membrane, to explore the effect of Sp unfolding on the membrane's mechanical properties, and on the thermal fluctuation of membrane-attached beads. At large deformations our results show a distinctive strain-induced unstiffening behavior, manifested in the slow decrease of the shear modulus, and accompanied by an increase in bead fluctuation. Bead fluctuation is also found to be influenced by mode switching, a phenomenon predicted by our three-dimensional model. The amount of stiffness reduction, however, is modest compared with that reported in experiments. A possible explanation for the discrepancy is the occurrence of spectrin head-to-head disassociation which is also included within our modeling framework and used to analyze bead motion as observed via experiment. PMID:18065469

  20. Long Sleep Duration Associated With a Higher Risk of Increased Arterial Stiffness in Males

    PubMed Central

    Tsai, Tsai-Chen; Wu, Jin-Shang; Yang, Yi-Ching; Huang, Ying-Hsiang; Lu, Feng-Hwa; Chang, Chih-Jen

    2014-01-01

    Study Objectives: We aimed to examine the association between sleep duration and arterial stiffness among adults of different ages, because to date there has been only one study on this relationship, which was confined to middle-aged civil servants. Design: Cross-sectional study. Setting: A health examination center in National Cheng Kung University Hospital, Taiwan. Participants: A total of 3,508 subjects, age 20–87 y, were enrolled after excluding those with a history of cerebrovascular events, coronary artery disease, peripheral artery disease, and taking lipid-lowering drugs, antihypertensives, hypoglycemic agents, and anti-inflammatory drugs, from October 2006 to August 2009. Interventions: N/A. Measurements and Results: Sleep duration was classified into three groups: short (< 6 h), normal (6–8 h) and long (> 8 h). Arterial stiffness was measured by brachial-ankle pulse-wave velocity (baPWV), and increased arterial stiffness was defined as baPWV ? 1400 cm/sec. The sleep duration was different for subjects with and without increased arterial stiffness in males, but not in females. In the multivariate analysis for males, long sleepers (odds ratio [OR] 1.75, P = 0.034) but not short sleepers (OR 0.98, P = 0.92) had a higher risk of increased arterial stiffness. In addition, age, estimated glomerular filtration rate, hypertension, diabetes, total cholesterol/high-density lipoprotein cholesterol ratio, cigarette smoking, and exercise were also independently associated factors. However, in females, neither short nor long sleep duration was associated with increased arterial stiffness. Conclusions: Long sleep duration was associated with a higher risk of increased arterial stiffness in males. Short sleepers did not exhibit a significant risk of increased arterial stiffness in either sex. Citation: Tsai TC, Wu JS, Yang YC, Huang YH, Lu FH, Chang CJ. Long sleep duration associated with a higher risk of increased arterial stiffness in males. SLEEP 2014;37(8):1315-1320. PMID:25083011

  1. Effects of the decellularization method on the local stiffness of acellular lungs.

    PubMed

    Melo, Esther; Garreta, Elena; Luque, Tomas; Cortiella, Joaquin; Nichols, Joan; Navajas, Daniel; Farré, Ramon

    2014-05-01

    Lung bioengineering, a novel approach to obtain organs potentially available for transplantation, is based on decellularizing donor lungs and seeding natural scaffolds with stem cells. Various physicochemical protocols have been used to decellularize lungs, and their performance has been evaluated in terms of efficient decellularization and matrix preservation. No data are available, however, on the effect of different decellularization procedures on the local stiffness of the acellular lung. This information is important since stem cells directly sense the rigidity of the local site they are engrafting to during recellularization, and it has been shown that substrate stiffness modulates cell fate into different phenotypes. The aim of this study was to assess the effects of the decellularization procedure on the inhomogeneous local stiffness of the acellular lung on five different sites: alveolar septa, alveolar junctions, pleura, and vessels' tunica intima and tunica adventitia. Local matrix stiffness was measured by computing Young's modulus with atomic force microscopy after decellularizing the lungs of 36 healthy rats (Sprague-Dawley, male, 250-300 g) with four different protocols with/without perfusion through the lung circulatory system and using two different detergents (sodium dodecyl sulfate [SDS] and 3-[(3-cholamidopropyl) dimethylammonio]-1-propanesulfonate [CHAPS]). The local stiffness of the acellular lung matrix significantly depended on the site within the matrix (p<0.001), ranging from ? 15 kPa at the alveolar septum to ? 60 kPa at the tunica intima. Acellular lung stiffness (p=0.003) depended significantly, albeit modestly, on the decellularization process. Whereas perfusion did not induce any significant differences in stiffness, the use of CHAPS resulted in a ? 35% reduction compared with SDS, the influence of the detergent being more important in the tunica intima. In conclusion, lung matrix stiffness is considerably inhomogeneous, and conventional decellularization procedures do not result in substantially different local stiffness in the acellular lung. PMID:24083889

  2. Liver Stiffness Is Associated With Monocyte Activation in HIV-Infected Ugandans Without Viral Hepatitis

    PubMed Central

    Wendel, Sarah K.; Grabowski, Mary K.; Ocama, Ponsiano; Kiggundu, Valerian; Bbosa, Francis; Boaz, Iga; Balagopal, Ashwin; Reynolds, Steven J.; Gray, Ronald H.; Serwadda, David; Kirk, Gregory D.; Quinn, Thomas C.; Stabinski, Lara

    2013-01-01

    Abstract A high prevalence of liver stiffness, as determined by elevated transient elastography liver stiffness measurement, was previously found in a cohort of HIV-infected Ugandans in the absence of chronic viral hepatitis. Given the role of immune activation and microbial translocation in models of liver disease, a shared immune mechanism was hypothesized in the same cohort without other overt causes of liver disease. This study examined whether HIV-related liver stiffness was associated with markers of immune activation or microbial translocation (MT). A retrospective case-control study of subjects with evidence of liver stiffness as defined by a transient elastography stiffness measurement ?9.3?kPa (cases=133) and normal controls (n=133) from Rakai, Uganda was performed. Cases were matched to controls by age, gender, HIV, hepatitis B virus (HBV), and highly active antiretroviral therapy (HAART) status. Lipopolysaccharide (LPS), endotoxin IgM antibody, soluble CD14 (sCD14), C-reactive protein (CRP), and D-dimer levels were measured. Conditional logistic regression was used to estimate adjusted matched odds ratios (adjMOR) and 95% confidence intervals. Higher sCD14 levels were associated with a 19% increased odds of liver stiffness (adjMOR=1.19, p=0.002). In HIV-infected individuals, higher sCD14 levels were associated with a 54% increased odds of having liver stiffness (adjMOR=1.54, p<0.001); however, the opposite was observed in HIV-negative individuals (adjMOR=0.57, p=0.001). No other biomarker was significantly associated with liver stiffness, and only one subject was found to have detectable LPS. Liver stiffness in HIV-infected Ugandans is associated with increased sCD14 indicative of monocyte activation in the absence of viral hepatitis or microbial translocation, and suggests that HIV may be directly involved in liver disease. PMID:23548102

  3. Coupling coefficients for tensor product representations of quantum SU(2)

    SciTech Connect

    Groenevelt, Wolter

    2014-10-15

    We study tensor products of infinite dimensional irreducible {sup *}-representations (not corepresentations) of the SU(2) quantum group. We obtain (generalized) eigenvectors of certain self-adjoint elements using spectral analysis of Jacobi operators associated to well-known q-hypergeometric orthogonal polynomials. We also compute coupling coefficients between different eigenvectors corresponding to the same eigenvalue. Since the continuous spectrum has multiplicity two, the corresponding coupling coefficients can be considered as 2 × 2-matrix-valued orthogonal functions. We compute explicitly the matrix elements of these functions. The coupling coefficients can be considered as q-analogs of Bessel functions. As a results we obtain several q-integral identities involving q-hypergeometric orthogonal polynomials and q-Bessel-type functions.

  4. Comparison of the Reliability of Acoustic Radiation Force Impulse Imaging and Supersonic Shear Imaging in Measurement of Liver Stiffness.

    PubMed

    Woo, Hyunsik; Lee, Jae Young; Yoon, Jeong Hee; Kim, Won; Cho, Belong; Choi, Byung Ihn

    2015-12-01

    Purpose To compare the reliability of acoustic radiation force impulse (ARFI) imaging and supersonic shear imaging (SSI) in measurement of liver stiffness. Materials and Methods This study was approved by the institutional review board, and written informed consent was obtained for all patients. Seventy-nine patients (25 healthy patients, 26 with Child-Pugh class A, and 28 with Child-Pugh class B or C) were enrolled and analyzed from April 2012 to April 2013. In each patient, three abdominal radiologists performed nine measurements of hepatic shear-wave speed with both ARFI imaging and SSI on the same day. Four weeks later, a second session was performed with the same protocol. Interobserver and intraobserver agreements were calculated by using intraclass correlation coefficients. Technical failures and measurement time were evaluated. Results There were four technical failures in the SSI group and one in the ARFI group (P = .375). The overall interobserver agreement of ARFI imaging was significantly higher than that of SSI (0.941 vs 0.828, P < .001). The overall intraobserver agreement of ARFI imaging was significantly higher than that of SSI (0.915 vs 0.829, P < .001). The overall shear-wave speed measured with SSI was higher than that measured with ARFI imaging (2.04 m/sec ± 0.88 vs 1.80 m/sec ± 0.81, P < .001). The measurement time of SSI was longer than that of ARFI imaging (310.8 seconds ± 88.5 vs 84.5 seconds ± 15.4, P < .001). Conclusion ARFI imaging was more reliable than SSI in measurement of liver stiffness. The hepatic shear-wave speed measured with SSI was higher than that measured with ARFI imaging, which means that the shear-wave speeds measured with ARFI imaging and SSI cannot be used interchangeably. (©) RSNA, 2015. PMID:26147680

  5. On Association Coefficients for 2x2 Tables and Properties that Do Not Depend on the Marginal Distributions

    ERIC Educational Resources Information Center

    Warrens, Matthijs J.

    2008-01-01

    We discuss properties that association coefficients may have in general, e.g., zero value under statistical independence, and we examine coefficients for 2x2 tables with respect to these properties. Furthermore, we study a family of coefficients that are linear transformations of the observed proportion of agreement given the marginal…

  6. SILICOMB PEEK Kirigami cellular structures: mechanical response and energy dissipation through zero and negative stiffness

    NASA Astrophysics Data System (ADS)

    Virk, K.; Monti, A.; Trehard, T.; Marsh, M.; Hazra, K.; Boba, K.; Remillat, C. D. L.; Scarpa, F.; Farrow, I. R.

    2013-08-01

    The work describes the manufacturing, testing and parametric analysis of cellular structures exhibiting zero Poisson’s ratio-type behaviour, together with zero and negative stiffness effects. The cellular structures are produced in flat panels and curved configurations, using a combination of rapid prototyping techniques and Kirigami (Origami and cutting) procedures for PEEK (Polyether Ether Ketone) thermoplastic composites. The curved cellular configurations show remarkable large deformation behaviours, with zero and negative stiffness regimes depending also on the strain rate applied. These unusual stiffness characteristics lead to a large increase of energy absorption during cyclic tests.

  7. Strain energy release rate, interlaminar stresses, and 3-D transformation of stiffnesses

    NASA Technical Reports Server (NTRS)

    1988-01-01

    In this analysis, a delamination between the belt and core sections is assumed to grow parallel to the belt direction in the tapered and uniform sections. These delaminations in each section are denoted by a and b respectively. The core section in the taper portion is modeled by two equivalent sublaminates. The stiffness properties are smeared to obtain effective cracked and uncracked stiffnesses which are designated A (u) and A (c). These stiffnesses change from one ply drop group to another with crack growth a by experiencing a sudden change at discrete locations. Therefore, A (u) and A (c) can be represented in three consecutive regions.

  8. On the problem of determination of spring stiffness parameters for spring-mesh models.

    PubMed

    Quang Huy Viet, Huynh; Hirai, Shinichi; Shirai, Yoshiaki; Yamaguchi, Satoshi; Tanaka, Hiromi T; Kawasaki, Hiroshi; Kawai, Yukiko

    2008-01-01

    On account of having real-time behavior and being easy to implement, spring meshes have been used for modeling deformable objects. Determining spring stiffness parameters for simulation of soft objects with high accuracy still remains a challenge. Allen Van Gelder derived an approximate formula for determining spring stiffness parameters based on strain analysis. Even though the experimental result showed the effectiveness, the method has not been investigated from a quantitative point of view. In this paper we propose a quantitative method for determining spring stiffness parameters. Moreover we propose a method to improve the accuracy by way of introducing torsional spring into the conventional spring mesh model. PMID:18391282

  9. Quantification of Myocardial Stiffness using Magnetic Resonance Elastography in Right Ventricular Hypertrophy: Initial Feasibility in Dogs

    PubMed Central

    da Silveira, Juliana S; Scansen, Brian A; Wassenaar, Peter A; Raterman, Brian; Eleswarpu, Chethan; Jin, Ning; Mo, Xiaokui; White, Richard D; Bonagura, John D; Kolipaka, Arunark

    2015-01-01

    Introduction Myocardial stiffness is an important determinant of cardiac function and is currently invasively and indirectly assessed by catheter angiography. This study aims to demonstrate the feasibility of quantifying right ventricular (RV) stiffness noninvasively using cardiac magnetic resonance elastography (CMRE) in dogs with severe congenital pulmonary valve stenosis (PVS) causing RV hypertrophy, and compare it to remote myocardium in the left ventricle (LV). Additionally, correlations between stiffness and selected pathophysiologic indicators from transthoracic echocardiography (TTE) and cardiac magnetic resonance imaging were explored. Methods In-vivo CMRE was performed on nine dogs presenting severe congenital PVS using a 1.5T MRI scanner. T1-MOLLI, T2-prepared-bSSFP, gated-cine GRE-MRE and LGE (PSIR) sequences were used to acquire a basal short-axis slice. RV and LV-free-wall (FW) stiffness measurements were compared against each other and also correlated to ventricular mass, RV and LV FW thickness, T1 and T2 relaxation times, and extracellular volume fraction (ECV). Peak transpulmonary pressure gradient and myocardial strain were also acquired on eight dogs by TTE and correlated to RV-FW systolic stiffness. Potential correlations were evaluated by Spearman’s rho (rs). Results RV-FW stiffness was found to be significantly higher than the LV-FW stiffness both during end-systole (ES) (p=0.002) and end-diastole (ED) (p=0.029). Significant correlations were observed between RV-FW ES and LV-FW ED stiffness versus ECV (rs=0.75; p-value=0.05). Non-significant moderate correlations were found between LV-FW ES (rs=0.54) and RV-FW ED (rs=0.61) versus ECV. Furthermore, non-significant correlations were found between RV or LV-FW stiffness and the remaining variables (rs<0.54; p-value>0.05). Conclusion This study demonstrates the feasibility of determining RV stiffness. The positive correlations between stiffness and ECV might indicate some interdependence between stiffness and myocardial extracellular matrix alterations. However, further studies are warranted to validate our initial observations. PMID:26471513

  10. Experimental procedure for the evaluation of tooth stiffness in spline coupling including angular misalignment

    NASA Astrophysics Data System (ADS)

    Curà, Francesca; Mura, Andrea

    2013-11-01

    Tooth stiffness is a very important parameter in studying both static and dynamic behaviour of spline couplings and gears. Many works concerning tooth stiffness calculation are available in the literature, but experimental results are very rare, above all considering spline couplings. In this work experimental values of spline coupling tooth stiffness have been obtained by means of a special hexapod measuring device. Experimental results have been compared with the corresponding theoretical and numerical ones. Also the effect of angular misalignments between hub and shaft has been investigated in the experimental planning.

  11. A numerical method to derive accurate temperature coefficients of material constants from high-temperature SAW measurements: application to langasite.

    PubMed

    Nicolay, Pascal; Aubert, Thierry

    2013-10-01

    The design of wireless SAW sensors for high-temperature applications requires accurate knowledge of the constitutive materials' physical properties in the desired temperature range. In particular, it is crucial to use reliable temperature coefficients of the stiffness, piezoelectric, dielectric, and expansion constants of the propagation medium to achieve correct simulations of the considered devices. Currently, the best-suited piezoelectric material for high-temperature SAW applications is langasite (LGS). Unfortunately, the available coefficients do not allow for precise prediction of the temperature dependence of LGS-based SAW devices above 300°C. A novel method, based on a simulated annealing algorithm coupled with a Rayleigh wave simulation program, was developed to find optimal LGS temperature coefficients. This approach has proven to yield accurate results up to at least 800°C. PMID:24081262

  12. Development of procedures for calculating stiffness and damping properties of elastomers in engineering applications. Part 1: Verification of basic methods

    NASA Technical Reports Server (NTRS)

    Chiang, T.; Tessarzik, J. M.; Badgley, R. H.

    1972-01-01

    The primary aim of this investigation was verification of basic methods which are to be used in cataloging elastomer dynamic properties (stiffness and damping) in terms of viscoelastic model constants. These constants may then be used to predict dynamic properties for general elastomer shapes and operating conditions, thereby permitting optimum application of elastomers as energy absorption and/or energy storage devices in the control of vibrations in a broad variety of applications. The efforts reported involved: (1) literature search; (2) the design, fabrication and use of a test rig for obtaining elastomer dynamic test data over a wide range of frequencies, amplitudes, and preloads; and (3) the reduction of the test data, by means of a selected three-element elastomer model and specialized curve fitting techniques, to material properties. Material constants thus obtained have been used to calculate stiffness and damping for comparison with measured test data. These comparisons are excellent for a number of test conditions and only fair to poor for others. The results confirm the validity of the basic approach of the overall program and the mechanics of the cataloging procedure, and at the same time suggest areas in which refinements should be made.

  13. On the distribution of seismic reflection coefficients and seismic amplitudes

    SciTech Connect

    Painter, S.; Paterson, L.; Beresford, G.

    1995-07-01

    Reflection coefficient sequences from 14 wells in Australia have a statistical character consistent with a non-Gaussian scaling noise model based on the Levy-stable family of probability distributions. Experimental histograms of reflection coefficients are accurately approximated by symmetric Levy-stable probability density functions with Levy index between 0.99 and 1.43. These distributions have the same canonical role in mathematical statistics as the Gaussian distribution, but they have slowly decaying tails and infinite moments. The distribution of reflection coefficients is independent of the spatial scale (statistically self-similar), and the reflection coefficient sequences have long-range dependence. These results suggest that the logarithm of seismic impedance can be modeled accurately using fractional Levy motion, which is a generalization of fractional Brownian motion. Synthetic seismograms produced from the authors` model for the reflection coefficients also have Levy-stable distributions. These isolations include transmission losses, the effects of reverberations, and the loss of resolution caused by band-limited wavelets, and suggest that actual seismic amplitudes with sufficient signal-to-noise ratio should also have a Levy-stable distribution. This prediction is verified using post-stack seismic data acquired in the Timor Sea and in the continental USA. However, prestack seismic amplitudes from the Timor Sea are nearly Gaussian. They attribute the difference between prestack and poststack data to the high level of measurement noise in the prestack data.

  14. Binomial coefficients and Littlewood-Richardson coefficients for interpolation polynomials and Macdonald polynomials

    E-print Network

    Miller, Stephen David

    Binomial coefficients and Littlewood-Richardson coefficients for interpolation polynomials establish a precise relationship between binomial coefficents and Littlewood-Richardson coefficients of coefficients. Introduction Let F = Q (q, t) denote the field of rational functions in q, t. In ([18], [6], [19

  15. Effective medium approach for stiff polymer networks with flexible cross-links

    E-print Network

    C. P. Broedersz; C. Storm; F. C. MacKintosh

    2008-11-24

    Recent experiments have demonstrated that the nonlinear elasticity of in vitro networks of the biopolymer actin is dramatically altered in the presence of a flexible cross-linker such as the abundant cytoskeletal protein filamin. The basic principles of such networks remain poorly understood. Here we describe an effective medium theory of flexibly cross-linked stiff polymer networks. We argue that the response of the cross-links can be fully attributed to entropic stiffening, while softening due to domain unfolding can be ignored. The network is modeled as a collection of randomly oriented rods connected by flexible cross-links to an elastic continuum. This effective medium is treated in a linear elastic limit as well as in a more general framework, in which the medium self-consistently represents the nonlinear network behavior. This model predicts that the nonlinear elastic response sets in at strains proportional to cross-linker length and inversely proportional to filament length. Furthermore, we find that the differential modulus scales linearly with the stress in the stiffening regime. These results are in excellent agreement with bulk rheology data.

  16. Distinct Impact of Two Keratin Mutations Causing Epidermolysis Bullosa Simplex on Keratinocyte Adhesion and Stiffness.

    PubMed

    Homberg, Melanie; Ramms, Lena; Schwarz, Nicole; Dreissen, Georg; Leube, Rudolf E; Merkel, Rudolf; Hoffmann, Bernd; Magin, Thomas M

    2015-10-01

    Keratin filaments constitute the major component of the epidermal cytoskeleton from heterodimers of type I and type II keratin subunits. Missense mutations in keratin 5 or keratin 14, highly expressed in the basal epidermis, cause the severe skin blistering disease epidermolysis bullosa simplex (EBS) in humans by rendering the keratin cytoskeleton sensitive to mechanical stress; yet, the mechanisms by which individual mutations cause cell fragility are incompletely understood. Here, we compared the K14p.Arg125Pro with the K5p.Glu477Asp mutation, both giving rise to severe generalized EBS, by stable expression in keratin-free keratinocytes. This revealed distinctly different effects on keratin cytoskeletal organization, in agreement with in vivo observations, thus validating the cell system. Although the K14p.Arg125Pro mutation led to impaired desmosomes, downregulation of desmosomal proteins, and weakened epithelial sheet integrity upon shear stress, the K5p.Glu477Asp mutation did not impair these functions, although causing EBS with squamous cell carcinoma in vivo. Atomic force microscopy demonstrated that K14 mutant cells were even less resistant against deformation compared with keratin-free keratinocytes. Thus, a keratin mutation causing EBS compromises cell stiffness to a greater extent than the lack of keratins. Finally, re-expression of K14 in K14 mutant cells did not rescue the above defects. Collectively, our findings have implications for EBS therapy approaches. PMID:25961909

  17. Comparison of numerical techniques for integration of stiff ordinary differential equations arising in combustion chemistry

    NASA Technical Reports Server (NTRS)

    Radhakrishnan, K.

    1984-01-01

    The efficiency and accuracy of several algorithms recently developed for the efficient numerical integration of stiff ordinary differential equations are compared. The methods examined include two general-purpose codes, EPISODE and LSODE, and three codes (CHEMEQ, CREK1D, and GCKP84) developed specifically to integrate chemical kinetic rate equations. The codes are applied to two test problems drawn from combustion kinetics. The comparisons show that LSODE is the fastest code currently available for the integration of combustion kinetic rate equations. An important finding is that an interactive solution of the algebraic energy conservation equation to compute the temperature does not result in significant errors. In addition, this method is more efficient than evaluating the temperature by integrating its time derivative. Significant reductions in computational work are realized by updating the rate constants (k = at(supra N) N exp(-E/RT) only when the temperature change exceeds an amount delta T that is problem dependent. An approximate expression for the automatic evaluation of delta T is derived and is shown to result in increased efficiency.

  18. Tire stiffness and damping determined from static and free-vibration tests. [aircraft tires

    NASA Technical Reports Server (NTRS)

    Sleeper, R. K.; Dreher, R. C.

    1980-01-01

    Stiffness and damping of a nonrolling tire were determined experimentally from both static force-displacement relations and the free-vibration behavior of a cable-suspended platen pressed against the tire periphery. Lateral and force-and-aft spring constants and damping factors of a 49 x 17 size aircraft tire for different tire pressure and vertical loads were measured assuming a rate-independent damping form. In addition, a technique was applied for estimating the magnitude of the tire mass which participates in the vibratory motion of the dynamic tests. Results show that both the lateral and force-and-aft spring constants generally increase with tire pressure but only the latter increased significantly with vertical tire loading. The fore-and-aft spring constants were greater than those in the lateral direction. The static-spring-constant variations were similar to the dynamic variations but exhibited lower magnitudes. Damping was small and insensitive to tire loading. Furthermore, static damping accounted for a significant portion of that found dynamically. Effective tire masses were also small.

  19. The role of body stiffness in wake production for anguilliform swimmers

    NASA Astrophysics Data System (ADS)

    Tytell, Eric; Leftwich, Megan; Hsu, Chia-Yu; Cohen, Aves; Fauci, Lisa; Smits, Alexander

    2011-11-01

    We compare wake structures shed by the undulatory motion of physical and computational models of an anguilliform swimmer, the lamprey. The physical model is a robotic lamprey-like swimmer with an actively flexing tail, and with passively flexible tails of different stiffnesses. The computational model is a two-dimensional computational fluid dynamic (CFD) model that captures fluid-structure interaction using the immersed boundary framework. The CFD model included both actively flexing and passively flexible tail regions. Both models produced wakes with two or more same-sign vortices shed each time the tail changed direction (a ``2P'' or higher- order wake). In general, wakes became less coherent as tail flexibility increased. We compare the pressure distribution near the tail tip and the timing of vortex formation in both cases and find good agreement. Differences between self-propelled and tethered cases are detailed. Finally, we examine the effects of material resonance on force production. Supported by NIH R01 NS054271.

  20. Row-Sum of a Class of M-Bonomial Coefficients

    ERIC Educational Resources Information Center

    Asiru, Muniru A.

    2011-01-01

    Formulae for row-sum of M-bonomial coefficients [image omitted] where G is an mth g-gonal number is developed from a study of the ratio between consecutive terms of the sequence of row-sum. The result generalizes the formula for row-sum of binomial coefficients: [image omitted].