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Sample records for genome horizons michael

  1. Genomes of Planktonic Acidimicrobiales: Widening Horizons for Marine Actinobacteria by Metagenomics

    PubMed Central

    Mizuno, Carolina Megumi; Ghai, Rohit

    2015-01-01

    ABSTRACT The genomes of four novel marine Actinobacteria have been assembled from large metagenomic data sets derived from the Mediterranean deep chlorophyll maximum (DCM). These are the first marine representatives belonging to the order Acidimicrobiales and only the second group of planktonic marine Actinobacteria to be described. Their streamlined genomes and photoheterotrophic lifestyle suggest that they are planktonic, free-living microbes. A novel rhodopsin clade, acidirhodopsins, related to freshwater actinorhodopsins, was found in these organisms. Their genomes suggest a capacity to assimilate C2 compounds, some using the glyoxylate bypass and others with the ethylmalonyl-coenzyme A (CoA) pathway. They are also able to derive energy from dimethylsulfopropionate (DMSP), sulfonate, and carbon monoxide oxidation, all commonly available in the marine habitat. These organisms appear to be prevalent in the deep photic zone at or around the DCM. The presence of sister clades to the marine Acidimicrobiales in freshwater aquatic habitats provides a new example of marine-freshwater transitions with potential evolutionary insights. PMID:25670777

  2. Following Michael Faraday's Footprints

    NASA Astrophysics Data System (ADS)

    Galeano, Javier

    2011-01-01

    Last fall I had the good fortune of receiving financial support to shoot a documentary about Michael Faraday. I took the opportunity to learn more about this great experimentalist and to visit the highlights of places in his life. In this paper, I would like to share a list and description of some of the most remarkable places in London suitable for following Michael Faraday's footprints. There are many other places in Europe of special interest for the physics teacher,2,3 and some useful guides to help us visit places as "scientific travelers,"4,5 but this paper focuses on Michael Faraday and London. I have personally visited most of the places described below and found the experience to be really worthwhile.

  3. Michael Faraday's Bicentenary.

    ERIC Educational Resources Information Center

    Williams, L. Pearce; And Others

    1991-01-01

    Six articles discuss the work of Michael Faraday, a chemist whose work revolutionized physics and led directly to both classical field and relativity theory. The scientist as a young man, the electromagnetic experiments of Faraday, his search for the gravelectric effect, his work on optical glass, his laboratory notebooks, and his creative use of…

  4. Following Michael Faraday's Footprints

    ERIC Educational Resources Information Center

    Galeano, Javier

    2011-01-01

    Last fall I had the good fortune of receiving financial support to shoot a documentary about Michael Faraday. I took the opportunity to learn more about this great experimentalist and to visit the highlights of places in his life. In this paper, I would like to share a list and description of some of the most remarkable places in London suitable…

  5. Goodbye Michael Gove

    ERIC Educational Resources Information Center

    Bassey, Michael

    2014-01-01

    Michael Gove was Secretary of State for Education from May 2010 to July 2014 when the Prime Minister sacked him. With strong opinions arising from his own life experiences and outstanding energy for reform, but severely limited understanding of education and a refusal to consult teachers and other professionals, he imposed half-baked ideas on the…

  6. Michael Faraday, media man.

    PubMed

    Fara, Patricia

    2006-03-01

    Michael Faraday was an enthusiastic portrait collector, and he welcomed the invention of photography not only as a possible means of recording observations accurately, but also as a method for advertising science and its practitioners. This article (which is part of the Science in the Industrial Revolution series) shows that like many eminent scientists, Faraday took advantage of the burgeoning Victorian media industry by posing in various roles. PMID:16332391

  7. Enantioselective Michael Addition of Water

    PubMed Central

    Chen, Bi-Shuang; Resch, Verena; Otten, Linda G; Hanefeld, Ulf

    2015-01-01

    The enantioselective Michael addition using water as both nucleophile and solvent has to date proved beyond the ability of synthetic chemists. Herein, the direct, enantioselective Michael addition of water in water to prepare important β-hydroxy carbonyl compounds using whole cells of Rhodococcus strains is described. Good yields and excellent enantioselectivities were achieved with this method. Deuterium labeling studies demonstrate that a Michael hydratase catalyzes the water addition exclusively with anti-stereochemistry. PMID:25529526

  8. Multitissue molecular, genomic, and developmental effects of the Deepwater Horizon oil spill on resident Gulf killifish (Fundulus grandis).

    PubMed

    Dubansky, Benjamin; Whitehead, Andrew; Miller, Jeffrey T; Rice, Charles D; Galvez, Fernando

    2013-05-21

    The Deepwater Horizon oil rig disaster resulted in crude oil contamination along the Gulf coast in sensitive estuaries. Toxicity from exposure to crude oil can affect populations of fish that live or breed in oiled habitats as seen following the Exxon Valdez oil spill. In an ongoing study of the effects of Deepwater Horizon crude oil on fish, Gulf killifish ( Fundulus grandis ) were collected from an oiled site (Grande Terre, LA) and two reference locations (coastal MS and AL) and monitored for measures of exposure to crude oil. Killifish collected from Grande Terre had divergent gene expression in the liver and gill tissue coincident with the arrival of contaminating oil and up-regulation of cytochrome P4501A (CYP1A) protein in gill, liver, intestine, and head kidney for over one year following peak landfall of oil (August 2011) compared to fish collected from reference sites. Furthermore, laboratory exposures of Gulf killifish embryos to field-collected sediments from Grande Terre and Barataria Bay, LA, also resulted in increased CYP1A and developmental abnormalities when exposed to sediments collected from oiled sites compared to exposure to sediments collected from a reference site. These data are predictive of population-level impacts in fish exposed to sediments from oiled locations along the Gulf of Mexico coast. PMID:23659337

  9. HORIZON SENSING

    SciTech Connect

    Larry G. Stolarczyk, Sc.D.

    2002-07-31

    Real-time horizon sensing (HS) on continuous mining (CM) machines is becoming an industry tool. Installation and testing of production-grade HS systems has been ongoing this quarter at Oxbow Mining Company, Monterey Coal Company (EXXON), FMC Trona, Twentymile Coal Company (RAG America), and SASOL Coal. Detailed monitoring of system function, user experience, and mining benefits is ongoing. All horizon sensor components have finished MSHA (United States) and IEC (International) certification.

  10. HORIZON SENSING

    SciTech Connect

    Larry G. Stolarczyk

    2003-03-18

    With the aid of a DOE grant (No. DE-FC26-01NT41050), Stolar Research Corporation (Stolar) developed the Horizon Sensor (HS) to distinguish between the different layers of a coal seam. Mounted on mining machine cutter drums, HS units can detect or sense the horizon between the coal seam and the roof and floor rock, providing the opportunity to accurately mine the section of the seam most desired. HS also enables accurate cutting of minimum height if that is the operator's objective. Often when cutting is done out-of-seam, the head-positioning function facilitates a fixed mining height to minimize dilution. With this technology, miners can still be at a remote location, yet cut only the clean coal, resulting in a much more efficient overall process. The objectives of this project were to demonstrate the feasibility of horizon sensing on mining machines and demonstrate that Horizon Sensing can allow coal to be cut cleaner and more efficiently. Stolar's primary goal was to develop the Horizon Sensor (HS) into an enabling technology for full or partial automation or ''agile mining''. This technical innovation (R&D 100 Award Winner) is quickly demonstrating improvements in productivity and miner safety at several prominent coal mines in the United States. In addition, the HS system can enable the cutting of cleaner coal. Stolar has driven the HS program on the philosophy that cutting cleaner coal means burning cleaner coal. The sensor, located inches from the cutting bits, is based upon the physics principles of a Resonant Microstrip Patch Antenna (RMPA). When it is in proximity of the rock-coal interface, the RMPA impedance varies depending on the thickness of uncut coal. The impedance is measured by the computer-controlled electronics and then sent by radio waves to the mining machine. The worker at the machine can read the data via a Graphical User Interface, displaying a color-coded image of the coal being cut, and direct the machine appropriately. The Horizon Sensor

  11. Killing Horizons Kill Horizon Degrees

    NASA Astrophysics Data System (ADS)

    Bergamin, L.; Grumiller, D.

    Frequently, it is argued that the microstates responsible for the Bekenstein-Hawking entropy should arise from some physical degrees of freedom located near or on the black hole horizon. In this essay, we elucidate that instead entropy may emerge from the conversion of physical degrees of freedom, attached to a generic boundary, into unobservable gauge degrees of freedom attached to the horizon. By constructing the reduced phase space, it can be demonstrated that such a transmutation indeed takes place for a large class of black holes, including Schwarzschild.

  12. Interview with Michael Gazzaniga.

    PubMed

    Gazzaniga, Michael

    2011-04-01

    Widely considered the father of the field of cognitive neuroscience, Professor Michael S. Gazzaniga is one of the world's premier neuroscientists. He founded the Center for Neuroscience at the University of California, Davis; the Center for Cognitive Neuroscience at Dartmouth College; the Cognitive Neuroscience Institute; Journal of Cognitive Neuroscience; and the Cognitive Neuroscience Society. He is currently the director of the Sage Center for the Study of the Mind at the University of California, Santa Barbara. Born on December 12, 1939 in Los Angeles and educated at Dartmouth College, he received his Ph.D. in psychobiology at the California Institute of Technology under the tutelage of Roger Sperry. As a graduate student, Professor Gazzaniga initiated the first lateralized testing of human split-brain patients, leading to a fundamental shift in our understanding of functional lateralization in the brain and how the cerebral hemispheres communicate with one another. His many scholarly publications and pioneering work during the last 50 years have produced significant contributions to our understanding of how the brain enables the mind. His landmark 1995 book for MIT Press, The Cognitive Neurosciences, now in its fourth edition, is recognized as the sourcebook for the field. He has also published many books accessible to a lay audience, including Mind Matters, Nature's Mind, and The Ethical Brain. PMID:21486292

  13. Genomic and genotoxic responses to controlled weathered-oil exposures confirm and extend field studies on impacts of the Deepwater Horizon oil spill on native killifish.

    PubMed

    Pilcher, Whitney; Miles, Scott; Tang, Song; Mayer, Greg; Whitehead, Andrew

    2014-01-01

    To understand the ecotoxicological impacts of the Deepwater Horizon oil spill, field studies provide a context for ecological realism but laboratory-based studies offer power for connecting biological effects with specific causes. As a complement to field studies, we characterized genome-wide gene expression responses of Gulf killifish (Fundulus grandis) to oil-contaminated waters in controlled laboratory exposures. Transcriptional responses to the highest concentrations of oiled water in the laboratory were predictive of field-observed responses that coincided with the timing and location of major oiling. The transcriptional response to the low concentration (∼ 10-fold lower than the high concentration) was distinct from the high concentration and was not predictive of major oiling in the field. The high concentration response was characterized by activation of the molecular signaling pathway that facilitates oil metabolism and oil toxicity. The high concentration also induced DNA damage. The low concentration invoked expression of genes that may support a compensatory response, including genes associated with regulation of transcription, cell cycle progression, RNA processing, DNA damage, and apoptosis. We conclude that the gene expression response detected in the field was a robust indicator of exposure to the toxic components of contaminating oil, that animals in the field were exposed to relatively high concentrations that are especially damaging to early life stages, and that such exposures can damage DNA. PMID:25208076

  14. Genomic and Genotoxic Responses to Controlled Weathered-Oil Exposures Confirm and Extend Field Studies on Impacts of the Deepwater Horizon Oil Spill on Native Killifish

    PubMed Central

    Pilcher, Whitney; Miles, Scott; Tang, Song; Mayer, Greg; Whitehead, Andrew

    2014-01-01

    To understand the ecotoxicological impacts of the Deepwater Horizon oil spill, field studies provide a context for ecological realism but laboratory-based studies offer power for connecting biological effects with specific causes. As a complement to field studies, we characterized genome-wide gene expression responses of Gulf killifish (Fundulus grandis) to oil-contaminated waters in controlled laboratory exposures. Transcriptional responses to the highest concentrations of oiled water in the laboratory were predictive of field-observed responses that coincided with the timing and location of major oiling. The transcriptional response to the low concentration (∼10-fold lower than the high concentration) was distinct from the high concentration and was not predictive of major oiling in the field. The high concentration response was characterized by activation of the molecular signaling pathway that facilitates oil metabolism and oil toxicity. The high concentration also induced DNA damage. The low concentration invoked expression of genes that may support a compensatory response, including genes associated with regulation of transcription, cell cycle progression, RNA processing, DNA damage, and apoptosis. We conclude that the gene expression response detected in the field was a robust indicator of exposure to the toxic components of contaminating oil, that animals in the field were exposed to relatively high concentrations that are especially damaging to early life stages, and that such exposures can damage DNA. PMID:25208076

  15. A Conversation with Michael Byram

    ERIC Educational Resources Information Center

    Wagner, Manuela

    2013-01-01

    In language teaching, it has been universally acknowledged that students need not just knowledge and skill in the grammar of a language but also the ability to use the language in socially and culturally appropriate ways. In this article Michael Byram, who has been working on Intercultural Competence for quite some time in a variety of different…

  16. Q&A: Michael Honey

    ERIC Educational Resources Information Center

    Helicher, Karl

    2007-01-01

    The mid-1960s saw civil rights victories in Congress during Lyndon B. Johnson's presidency. In "Going Down Jericho Road," Michael Honey wrote how Martin Luther King Jr.'s final focus showed that the struggle for black and working class parity continued. The 1968 Memphis sanitation workers strike was a gritty struggle won in the streets by a host…

  17. Michael Sadler and Comparative Education

    ERIC Educational Resources Information Center

    Phillips, David

    2006-01-01

    This paper examines the work in education of Michael Sadler (1861-1943). It covers his early years in Oxford, his time as director of the Department of Special Inquiries and Reports, his periods as professor of education in Manchester and as vice-chancellor in Leeds, and his return to Oxford as Master of University College, and it assesses the…

  18. Michael Beitz: Objects of Communication

    ERIC Educational Resources Information Center

    Hoefferle, Mary

    2014-01-01

    For this Instructional Resource, the author interviewed contemporary sculptor Michael Beitz, who uses art to explore the role of designed objects in human communication and emotional experience. This column was written in response to calls for using Enduring Understandings/Big Ideas (National Coalition for Core Arts Standards, 2013; Stewart &…

  19. Michael Faraday vs. the Spiritualists

    NASA Astrophysics Data System (ADS)

    Hirshfeld, Alan

    2006-12-01

    In the 1850s, renowned physicist Michael Faraday launched a public campaign against pseudoscience and spiritualism, which were rampant in England at the time. Faraday objected especially to claims that electrical or magnetic forces were responsible for paranormal phenomena, such as table-spinning and communication with the dead. Using scientific methods, Faraday unmasked the deceptions of spiritualists, clairvoyants and mediums and also laid bare the credulity of a public ill-educated in science. Despite his efforts, Victorian society's fascination with the paranormal swelled. Faraday's debacle anticipates current controversies about public science education and the interface between science and religion. This episode is one of many described in the new biography, The Electric Life of Michael Faraday (Walker & Co.), which chronicles Faraday's discoveries and his unlikely rise from poverty to the pinnacle of the English science establishment.

  20. The legacy of Michael Balint.

    PubMed

    Johnson, Alan H; Brock, Clive D; Zacarias, Ashleigh

    2014-01-01

    Michael Balint's lead article, "Repeat Prescription Patients: Are They An Identifiable Group?" inaugurated the first issue of Psychiatry in Medicine, Vol. 1, No. 1, 1970. A few years later, this Journal would be renamed International Journal of Psychiatry in Medicine (IJPM). Who is this author of over 165 papers, 10 books, practicing psychoanalyst from 1926 to 1970, director of the Budapest Psychoanalytic Institute from 1935 to 1939, consultant at the Tavistock Clinic from 1948 to 1961, President of the British Psycho-Analytical Society from 1968 to 1970, literary executor of Sandor Ferenczi, a foremost theorist of object relations, and international educator and statesman for general practitioners? We would like to review for you some of the formative experiences in Michael's life that wedded psychoanalysis and general practice, and how they contributed to his major educational commitment over 40 years to furthering the understanding and integration of psychosocial factors in the practice of primary healthcare as experienced by doctors all over the world. We would also like to highlight some of his major insights and see to what extent they are incorporated in contemporary medical education and practice. We believe that some of his major insights have been neglected and others have been further amplified and extended. Our intention is to speak not only to medical students who desire to pursue medicine related directly to patient care but as well to seasoned practitioners who continue on a daily basis to care for individual patients and their families. PMID:25084816

  1. Ron Dittemore and Michael Kostelnik

    NASA Technical Reports Server (NTRS)

    2003-01-01

    Ronald D. Dittemore (right), a 26-year NASA veteran, announces his intention to step aside as the Space Shuttle Program Manager at the Johnson Space Center in Houston to pursue other opportunities. Also pictured at the Washington, DC announcement is Michael Kostelnik, Deputy Associate Administrator for the Space Shuttle and International Space Station Programs. Dittemore, who has served as the Shuttle Program Manager for more than four years, will remain in his current position until the Columbia Accident Investigation Board finishes its investigation and a complete 'Return to Flight' path has been established. Dittemore retired recently, he had publicly planned to do so before the accident. For more information on STS-107, please see GRIN Columbia General Explanation

  2. Jack Michael's Motivation

    ERIC Educational Resources Information Center

    Miguel, Caio F.

    2013-01-01

    Among many of Jack Michael's contributions to the field of behavior analysis is his behavioral account of motivation. This paper focuses on the concept of "motivating operation" (MO) by outlining its development from Skinner's (1938) notion of "drive." Conceptually, Michael's term helped us change our focus on…

  3. Method for promoting Michael addition reactions

    DOEpatents

    Shah, Pankaj V.; Vietti, David E.; Whitman, David William

    2010-09-21

    Homogeneously dispersed solid reaction promoters having an average particle size from 0.01 .mu.m to 500 .mu.m are disclosed for preparing curable mixtures of at least one Michael donor and at least one Michael acceptor. The resulting curable mixtures are useful as coatings, adhesives, sealants and elastomers.

  4. Test pilot Michael R. Swann

    NASA Technical Reports Server (NTRS)

    1978-01-01

    Michael R. Swann joined the National Aeronautics and Space Administration's Dryden Flight Research Center on June 5, 1978, transferring from the NASA's Johnson Space Center, Houston, Texas, as a research pilot. Swann attended North Dakota State University, Fargo, North Dakota, from September 1968 to February 1977, where he earned his Masters in Physics. He was a member of three national honorary scholastic fraternities. Prior to joining NASA Swann served concurrently as an Aerospace Defense Command Interceptor pilot in the Air National Guard for five years and as a college physics instructor at North Dakota State University for two years. While at Johnson Space Center Mike was a pilot on high altitude earth resources and air sampling missions. He was also an instructor and check pilot for the Astronaut Space Flight Readiness Training program. As a Dryden research pilot Mike was involved with the F-111 #778 Transonic Aircraft Technology (TACT) program, F-15 # 281 Shuttle Tile tests, programs on the F-8C #802 and the PA-30 #808 Remotely Piloted Research Vehicle. He flew the Bell 47G #822 helicopter in support of research with the three-eighths-scale F-15 Spin Research Vehicle. On March 28, 1979, Mike made a pilot familiarization flight in the YF-12A #935. He also flew support flights in the F-104, C-47, T-37, T-38, and the Jetstar aircraft. Michael R. Swann was born June 5, 1949, in Fargo, North Dakota; he was fatally injured in a recreational glider accident on July 28, 1981, near California City, California.

  5. A General Organocatalyzed Michael-Michael Cascade Reaction Generates Functionalized Cyclohexenes

    PubMed Central

    McGarraugh, Patrick G.; Jones, Joshua H.; Brenner-Moyer, Stacey E.

    2011-01-01

    While β-dicarbonyl compounds are regularly employed as Michael donors, intermediates arising from the Michael addition of unsaturated β-ketoesters to α,β-unsaturated aldehydes are susceptible to multiple subsequent reaction pathways. We designed cyclic unsaturated β-ketoester substrates that enabled the development of the first diphenyl prolinol silyl ether-catalyzed Michael-Michael cascade reaction initiated by a β-dicarbonyl Michael donor to form cyclohexene products. The reaction conditions we developed for this Michael-Michael cascade reaction were also amenable to a variety of linear unsaturated β-ketoester substrates, including some of the same linear unsaturated β-ketoester substrates that were previously ineffective in Michael-Michael cascade reactions. These studies thus revealed that a change in simple reaction conditions, such as solvent and additives, enables the same substrate to undergo different cascade reactions, thereby accessing different molecular scaffolds. These studies also culminated in the development of a general organocatalyzed Michael-Michael cascade reaction that generates highly functionalized cyclohexenes with up to four stereocenters, in up to 97% yield, 32:1 dr, and 99% ee, in a single step from a variety of unsaturated β-ketoesters. PMID:21714480

  6. Michael Thackeray on Lithium-air Batteries

    SciTech Connect

    Thackeray, Michael

    2009-01-01

    Michael Thackeray, Distinguished Fellow at Argonne National Laboratory, speaks on the new technology Lithium-air batteries, which could potentially increase energy density by 5-10 times over lithium-ion batteries.

  7. ATV2 Interview with Michael Suffredini

    NASA Video Gallery

    International Space Station Manager Michael Suffredini answers questions about the European Space Agency’s second Automated Transfer Vehicle (ATV2), Johannes Kepler, set to launch from a launch p...

  8. Michael Thackeray on Lithium-air Batteries

    ScienceCinema

    Thackeray, Michael

    2013-04-19

    Michael Thackeray, Distinguished Fellow at Argonne National Laboratory, speaks on the new technology Lithium-air batteries, which could potentially increase energy density by 5-10 times over lithium-ion batteries.

  9. ASK Talks with Dr. Michael Hecht

    NASA Technical Reports Server (NTRS)

    Hecht, Michael

    2003-01-01

    Michael Hecht has been a member of NASA's Jet Propulsion Laboratory (JPL) staff since 1982. He is currently Project Manager and co-investigator for the Mars Environmental Compatibility Assessment (MECA)

  10. [Early career of Michael Sendivogius].

    PubMed

    Prinke, Rafał T

    2012-01-01

    One of the most influential alchemical authors of the early modern period was Michael Sendivogius whose early life is shrouded in mystery. He may be labelled the most famous Polish scientific writer between Copernicus and Marie Skłodowska-Curie, but because of the difficulties involved in researching the biography of any alchemist, there has been relatively little interest in him among Polish historians. The early work of Roman Bugaj (author of the still fundamental monograph) and Włodzimierz Hubicki (who made his research available to the international community) has been continued only by the English-born Zbigniew Szydło and the author of this article. The roots of many legends about Sendivogius were three mid-17th century short biographies, none of which is trustworthy, so it is crucial to verify the received myth and the version constructed in the 1960's and 1970's with primary sources and evidence from the recent "new historiography of alchemy". The present article examines them in the light of newly discovered sources and reinterpretation of the old ones. The genealogy of the Sedzimir family is discussed at length to show that Sendivogius most probably was not its member but only a pretender in order to assume (or prove) the status of a nobleman. Several possible hypotheses about his origins are presented. He is known to have studied at three universities (Leipzig, Vienna and Altdorf) but authors of early panegyrics dedicated to Sendivogius list more universities which he may have attended. The most interesting is that of Cambridge, listed as the first one, because practically no Poles or Czechs went there at the time. Finally, his marriage to Veronica Stiebar, a wealthy widow of a Franconian knightly family, and her interesting family relationships (links to Erasmus, Camerarius, Paracelsus and the original Doctor Faustus) are discussed. The period covered is that before Sendivogius moved to Prague in about 1597, having already been a courtier of Rudolf II

  11. Semiclassical ultraextremal horizons

    SciTech Connect

    Matyjasek, Jerzy; Zaslavskii, O.B.

    2005-04-15

    We examine backreaction of quantum massive fields on multiply-degenerate (ultraextremal) horizons. It is shown that, under influence of the quantum backreaction, the horizon of such a kind moves to a new position near which the metric does not change its asymptotics, so the ultraextremal black holes and cosmological spacetimes do exist as self-consistent solutions of the semiclassical field equations.

  12. The 2011 Horizon Report

    ERIC Educational Resources Information Center

    Johnson, L.; Smith, R.; Willis, H.; Levine, A.; Haywood, K.

    2011-01-01

    The internationally recognized series of "Horizon Reports" is part of the New Media Consortium's Horizon Project, a comprehensive research venture established in 2002 that identifies and describes emerging technologies likely to have a large impact over the coming five years on a variety of sectors around the globe. This volume, the "2011 Horizon…

  13. Two Horizons of Fusion

    ERIC Educational Resources Information Center

    Lo, Mun Ling; Chik, Pakey Pui Man

    2016-01-01

    In this paper, we aim to differentiate the internal and external horizons of "fusion." "Fusion" in the internal horizon relates to the structure and meaning of the object of learning as experienced by the learner. It clarifies the interrelationships among an object's critical features and aspects. It also illuminates the…

  14. The 2010 Horizon Report

    ERIC Educational Resources Information Center

    Johnson, L.; Levine, A.; Smith, R.; Stone, S.

    2010-01-01

    The annual "Horizon Report" describes the continuing work of the New Media Consortium's Horizon Project, a qualitative research project established in 2002 that identifies and describes emerging technologies likely to have a large impact on teaching, learning, or creative inquiry on college and university campuses within the next five years. The…

  15. Fuzziness at the horizon

    NASA Astrophysics Data System (ADS)

    Batic, Davide; Nicolini, Piero

    2010-08-01

    We study the stability of the noncommutative Schwarzschild black hole interior by analysing the propagation of a massless scalar field between the two horizons. We show that the spacetime fuzziness triggered by the field higher momenta can cure the classical exponential blue-shift divergence, suppressing the emergence of infinite energy density in a region nearby the Cauchy horizon.

  16. Direct Diastereo- and Enantioselective Vinylogous Michael Additions of Linear Enones.

    PubMed

    Guo, Qunsheng; Fraboni, Americo J; Brenner-Moyer, Stacey E

    2016-06-01

    A direct vinylogous Michael addition using linear vinylogous Michael donors has been developed. Notably, even γ-substituted Michael donors cleanly afforded γ-alkylated products in high yield and ee by this method. Moreover, control experiments revealed that, for these and related linear vinylogous Michael donors, the size of the Michael acceptor strongly influences whether α- or γ-alkylation occurs, not simply blocking effects of cocatalysts as suggested previously. PMID:27186662

  17. New Horizons at Pluto

    NASA Astrophysics Data System (ADS)

    Schenk, Paul; Nimmo, Francis

    2016-06-01

    The New Horizons mission has revealed Pluto and its moon Charon to be geologically active worlds. The familiar, yet exotic, landforms suggest that geologic processes operate similarly across the Solar System, even in its cold outer reaches.

  18. Infrared horizon locator

    NASA Technical Reports Server (NTRS)

    Jalink, A., Jr. (Inventor)

    1973-01-01

    A precise method and apparatus for locating the earth's infrared horizon from space that is independent of season and latitude is described. First and second integrations of the earth's radiance profile are made from space to earth with the second delayed with respect to the first. The second integration is multiplied by a predetermined constant R and then compared with the first integration. When the two are equal the horizon is located.

  19. Michael Tomasello: Award for Distinguished Scientific Contributions.

    PubMed

    2015-11-01

    The APA Awards for Distinguished Scientific Contributions are presented to persons who, in the opinion of the Committee on Scientific Awards, have made distinguished theoretical or empirical contributions to basic research in psychology. One of the 2015 award winners is Michael Tomasello, who received this award for "outstanding empirical and theoretical contributions to understanding what makes the human mind unique. Michael Tomasello's pioneering research on the origins of social cognition has led to revolutionary insights in both developmental psychology and primate cognition." Tomasello's award citation, biography, and a selected bibliography are presented here. PMID:26618943

  20. Reframing Michael Scott: Exploring Inappropriate Workplace Communication

    ERIC Educational Resources Information Center

    Schaefer, Zachary A.

    2010-01-01

    Individuals who work in professional settings interact with others who may exhibit a variety of cultural beliefs and decision-making approaches. Page (2007) argues that cognitive diversity (i.e., how people approach and attempt to solve problems) is a vital asset in effective organizations. Michael Scott, who portrays the inept main character on…

  1. Solving the Housing Equation: Michael P. Johnson

    ERIC Educational Resources Information Center

    Roach, Ronald

    2005-01-01

    Dr. Michael P. Johnson, an associate professor of management science and urban affairs at the H. John Heinz III School of Public Policy and Management at Carnegie Mellon University in Pittsburgh, is taking management science tools and innovative information technology applications to the housing field. Concerned that organizations that develop and…

  2. Michael Slote and "Sentimentalist Moral Education"

    ERIC Educational Resources Information Center

    Wren, Thomas

    2010-01-01

    Although I think most of what Michael Slote asserts in his article "Sentimentalist moral education" is correct, I worry about three important ideas that are conspicuous by their absence. The first is the possibility that human emotions and feelings are inherently cognitive, which is never considered in his psychological account of empathy. The…

  3. International Humanitarian Award: Michael G. Wessells

    ERIC Educational Resources Information Center

    American Psychologist, 2009

    2009-01-01

    Michael G. Wessells, recipient of the International Humanitarian Award, is cited for his pioneering and sustained contributions to the protection of children affected by armed conflict and to the development of international guidelines for the provision of community-based, culturally responsive psychosocial support in emergencies. Wessells has…

  4. Against Dogma: A Reply to Michael Swan.

    ERIC Educational Resources Information Center

    Widdowson, H. G.

    1985-01-01

    Replies to two articles by Michael Swan entitled "A Critical Look at the Communicative Approach." Argues that Swan presents a distorted version of the communicative approach so as to present his own ideas more effectively and that he fails to offer evidence for his position on the practice of English language teaching. (SED)

  5. Michael Polanyi 1891-1976: A Rememberance

    ERIC Educational Resources Information Center

    Manno, Bruno V.

    1977-01-01

    Michael Polanyi was on "JHP's" Board of Editors for many years, and his book, "Personal Knowledge", published in 1958, was an important factor in the development of humanistic psychology. This "rememberance" presents an overview of his personal background and the major outlines of his thought. (Editor/RK)

  6. Comments on Michael (1993): Establishing Operations

    ERIC Educational Resources Information Center

    Moore, J.

    2013-01-01

    The present comments concern Michael's concept of motivative variables, and the implications of that concept for our understanding of the nature of reinforcement as well as the extinction of responses maintained through positive and negative reinforcement. We note that both extinction and altering motivative variables decrease responding, but…

  7. Michael Gorman vs. Web 2.0

    ERIC Educational Resources Information Center

    Chronicle of Higher Education, 2007

    2007-01-01

    In a much-discussed series of postings on the Encyclopaedia Britannica Online Web site, Michael Gorman, former president of the American Library Association and the recently retired dean of library services at California State University at Fresno, argues that the "often-anarchic world of the Internet" is saturating people's culture with a "tide…

  8. Michael Walzer's Politics, in Theory and Practice

    ERIC Educational Resources Information Center

    Williams, Jeffrey J.

    2012-01-01

    Before all the talk about "public intellectuals," Michael Walzer was one. For 50 years, he has gone back and forth between positions at Princeton and Harvard Universities and then at the Institute for Advanced Study, in Princeton, New Jersey, where he is now emeritus. His writings appear regularly in "Dissent" magazine, which he has co-edited for…

  9. 4. Photocopy of inkandwatercolor drawing (from St. Michael's Church) Rambusch, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Photocopy of ink-and-watercolor drawing (from St. Michael's Church) Rambusch, illustrator ca. 1932-37 INTERIOR, LOOKING NORTHEAST - St. Michael's Catholic Church, 519 East Third Street, Madison, Jefferson County, IN

  10. Firewall or smooth horizon?

    NASA Astrophysics Data System (ADS)

    Ori, Amos

    2016-01-01

    Almheiri, Marolf, Polchinski, and Sully pointed out that for a sufficiently old black hole (BH), the set of assumptions known as the complementarity postulates appears to be inconsistent with the assumption of local regularity at the horizon. They concluded that the horizon of an old BH is likely to be the locus of local irregularity, a "firewall". Here I point out that if one adopts a different assumption, namely that semiclassical physics holds throughout its anticipated domain of validity, then the inconsistency is avoided, and the horizon retains its regularity. In this alternative view-point, the vast portion of the original BH information remains trapped inside the BH throughout the semiclassical domain of evaporation, and possibly leaks out later on. This appears to be an inevitable outcome of semiclassical gravity (if assumed to apply throughout its anticipated domain of validity).

  11. Stable predictive control horizons

    NASA Astrophysics Data System (ADS)

    Estrada, Raúl; Favela, Antonio; Raimondi, Angelo; Nevado, Antonio; Requena, Ricardo; Beltrán-Carbajal, Francisco

    2012-04-01

    The stability theory of predictive and adaptive predictive control for processes of linear and stable nature is based on the hypothesis of a physically realisable driving desired trajectory (DDT). The formal theoretical verification of this hypothesis is trivial for processes with a stable inverse, but it is not for processes with an unstable inverse. The extended strategy of predictive control was developed with the purpose of overcoming methodologically this stability problem and it has delivered excellent performance and stability in its industrial applications given a suitable choice of the prediction horizon. From a theoretical point of view, the existence of a prediction horizon capable of ensuring stability for processes with an unstable inverse was proven in the literature. However, no analytical solution has been found for the determination of the prediction horizon values which guarantee stability, in spite of the theoretical and practical interest of this matter. This article presents a new method able to determine the set of prediction horizon values which ensure stability under the extended predictive control strategy formulation and a particular performance criterion for the design of the DDT generically used in many industrial applications. The practical application of this method is illustrated by means of simulation examples.

  12. Boosted apparent horizons

    NASA Astrophysics Data System (ADS)

    Akcay, Sarp

    Boosted black holes play an important role in General Relativity (GR), especially in relation to the binary black hole problem. Solving Einstein vac- uum equations in the strong field regime had long been the holy grail of numerical relativity until the significant breakthroughs made in 2005 and 2006. Numerical relativity plays a crucial role in gravitational wave detection by providing numerically generated gravitational waveforms that help search for actual signatures of gravitational radiation exciting laser interferometric de- tectors such as LIGO, VIRGO and GEO600 here on Earth. Binary black holes orbit each other in an ever tightening adiabatic inspiral caused by energy loss due to gravitational radiation emission. As the orbits shrinks, the holes speed up and eventually move at relativistic speeds in the vicinity of each other (separated by ~ 10M or so where 2M is the Schwarzschild radius). As such, one must abandon the Newtonian notion of a point mass on a circular orbit with tangential velocity and replace it with the concept of black holes, cloaked behind spheroidal event horizons that become distorted due to strong gravity, and further appear distorted because of Lorentz effects from the high orbital velocity. Apparent horizons (AHs) are 2-dimensional boundaries that are trapped surfaces. Conceptually, one can think of them as 'quasi-local' definitions for a black hole horizon. This will be explained in more detail in chapter 2. Apparent horizons are especially important in numerical relativity as they provide a computationally efficient way of describing and locating a black hole horizon. For a stationary spacetime, apparent horizons are 2-dimensional cross-sections of the event horizon, which is itself a 3-dimensional null surface in spacetime. Because an AH is a 2-dimensional cross-section of an event horizon, its area remains invariant under distortions due to Lorentz boosts although its shape changes. This fascinating property of the AH can be

  13. Michael J. Fox and his Parkinson's disease.

    PubMed

    Kempster, Peter A

    2004-01-01

    Michael J. Fox was a popular and successful film and television comic actor who developed Parkinson's disease at the age of 29 years. His recently published book, Lucky Man, structured around the story of his Parkinson's disease, is an amusing, briskly paced yet introspective memoir that covers the first 40 years of his life. Although quite anecdotal, it contains interesting observations on the preclinical phase of the disorder, evolution of motor fluctuations, and tactics for pharmacological treatment. PMID:14743369

  14. Instability of enclosed horizons

    NASA Astrophysics Data System (ADS)

    Kay, Bernard S.

    2015-03-01

    We point out that there are solutions to the scalar wave equation on dimensional Minkowski space with finite energy tails which, if they reflect off a uniformly accelerated mirror due to (say) Dirichlet boundary conditions on it, develop an infinite stress-energy tensor on the mirror's Rindler horizon. We also show that, in the presence of an image mirror in the opposite Rindler wedge, suitable compactly supported arbitrarily small initial data on a suitable initial surface will develop an arbitrarily large stress-energy scalar near where the two horizons cross. Also, while there is a regular Hartle-Hawking-Israel-like state for the quantum theory between these two mirrors, there are coherent states built on it for which there are similar singularities in the expectation value of the renormalized stress-energy tensor. We conjecture that in other situations with analogous enclosed horizons such as a (maximally extended) Schwarzschild black hole in equilibrium in a (stationary spherical) box or the (maximally extended) Schwarzschild-AdS spacetime, there will be similar stress-energy singularities and almost-singularities—leading to instability of the horizons when gravity is switched on and matter and gravity perturbations are allowed for. All this suggests it is incorrect to picture a black hole in equilibrium in a box or a Schwarzschild-AdS black hole as extending beyond the past and future horizons of a single Schwarzschild (/Schwarzschild-AdS) wedge. It would thus provide new evidence for 't Hooft's brick wall model while seeming to invalidate the picture in Maldacena's ` Eternal black holes in AdS'. It would thereby also support the validity of the author's matter-gravity entanglement hypothesis and of the paper ` Brick walls and AdS/CFT' by the author and Ortíz.

  15. A rapid whole genome sequencing and analysis system supporting genomic epidemiology (7th Annual SFAF Meeting, 2012)

    ScienceCinema

    FitzGerald, Michael [Broad Institute

    2013-02-12

    Michael FitzGerald on "A rapid whole genome sequencing and analysis system supporting genomic epidemiology" at the 2012 Sequencing, Finishing, Analysis in the Future Meeting held June 5-7, 2012 in Santa Fe, New Mexico.

  16. A rapid whole genome sequencing and analysis system supporting genomic epidemiology (7th Annual SFAF Meeting, 2012)

    SciTech Connect

    FitzGerald, Michael

    2012-06-01

    Michael FitzGerald on "A rapid whole genome sequencing and analysis system supporting genomic epidemiology" at the 2012 Sequencing, Finishing, Analysis in the Future Meeting held June 5-7, 2012 in Santa Fe, New Mexico.

  17. Spacetimes containing slowly evolving horizons

    SciTech Connect

    Kavanagh, William; Booth, Ivan

    2006-08-15

    Slowly evolving horizons are trapping horizons that are ''almost'' isolated horizons. This paper reviews their definition and discusses several spacetimes containing such structures. These include certain Vaidya and Tolman-Bondi solutions as well as (perturbatively) tidally distorted black holes. Taking into account the mass scales and orders of magnitude that arise in these calculations, we conjecture that slowly evolving horizons are the norm rather than the exception in astrophysical processes that involve stellar-scale black holes.

  18. Obituary: Michael James Ledlow, 1964-2004

    NASA Astrophysics Data System (ADS)

    Puxley, Philip John; Grashuis, Randon M.

    2004-12-01

    Michael James Ledlow died on 5 June 2004 from a large, unsuspected brain tumor. Since 2000 he had been on the scientific staff of the Gemini Observatory in La Serena, Chile, initially as a Science Fellow and then as a tenure-track astronomer. Michael was born in Bartlesville, Oklahoma on 1 October 1964 to Jerry and Sharon Ledlow. He obtained his Bachelor Degree in astrophysics at the University of Oklahoma in 1987 and attended the University of New Mexico for his graduate work, obtaining his PhD while studying Galaxy Clusters under Frazer Owen in 1994. From 1995-1997 Michael held a postdoctoral position with Jack Burns at New Mexico State University where he used various astronomical facilities including the VLA and Apache Point Observatory to study distant galaxies. From 1998-2000 Michael rejoined the Physics and Astronomy Department at the University of New Mexico where he was a visiting professor until he moved on to Gemini. At the Gemini Observatory, Mike shared in the excitement, hard work and many long days and nights associated with bringing on-line a major new astronomical facility and its instrumentation. Following its commissioning he assisted visiting observers, supported and took data for many more remote users via the queue system, and for each he showed the same care and attention to detail evident in his own research to ensure that all got the best possible data. His research concentrated on the radio and optical properties of galaxy clusters, especially rich Abell clusters such as A2125, on luminous radio galaxies, including the detection of a powerful double radio source in the "wrong sort of galaxy," the spiral system 0313-192, and on EROs (extremely red objects), dusty galaxies barely detectable at optical wavelengths. Michael thoroughly enjoyed living in Chile and enthusiastically immersed himself in the culture of his surroundings. He and his family were actively involved with the International English Spanish Association in La Serena. He had a

  19. Refraction near the horizon

    NASA Technical Reports Server (NTRS)

    Schaefer, Bradley E.; Liller, William

    1990-01-01

    Variations in astronomical refraction near the horizon are examined. Sunset timings, a sextant mounted on a tripod, and a temperature profile are utilized to derive the variations in refraction data, collected from 7 locations. It is determined that the refraction ranges from 0.234 to 1.678 deg with an rms deviation of 0.16, and it is observed that the variation is larger than previously supposed. Some applications for the variation of refraction value are discussed.

  20. Richard Michael Suzman (1942-2015).

    PubMed

    Kahneman, Daniel

    2016-01-01

    Presents an obituary for Richard Michael Suzman, who died on April 16, 2015. Suzman was trained as a sociologist and anthropologist, but he was attracted to the approaches of demography and economics. He came to know a great deal about diverse fields of science, including health, physiology, psychology, genetics, and economics. He was a scientific leader who was on a quest to develop new transdisciplinary fields and to mobilize the best scientists to work in them. Suzman's passion for transdisciplinary science was fully expressed in his greatest achievement: the famous Health and Retirement Survey (HRS), which he initiated in 1988 and continued to guide and inspire. (PsycINFO Database Record PMID:27504580

  1. Gravitational Horizon(3)

    NASA Astrophysics Data System (ADS)

    Yang, Chao Yuan

    2012-05-01

    Anomalous decelerations of spacecraft Pioneer-10,11,etc could be interpreted as signal delay effect between speed of gravity and that of light as reflected in virtual scale, similar to covarying virtual scale effect in relative motion (http://arxiv.org/html/math-ph/0001019v5).A finite speed of gravity faster than light could be inferred (http://arXiv.org/html/physics/0001034v2). Measurements of gravitational variations by paraconical pendulum during a total solar eclipse infer the same(http://arXiv.org/html/physics/0001034v9). A finite Superluminal speed of gravity is the necessary condition to imply that there exists gravitational horizon (GH). Such "GH" of our Universe would stretch far beyond the cosmic event horizon of light. Dark energy may be owing to mutually interactive gravitational horizons of cousin universes. Sufficient condition for the conjecture is that the dark energy would be increasing with age of our Universe since accelerated expansion started about 5 Gyr ago, since more and more arrivals of "GH" of distant cousin universes would interact with "GH" of our Universe. The history of dark energy variations between then and now would be desirable(http://arXiv.org/html/physics/0001034). In "GH" conjecture, the neighborhood of cousin universes would be likely boundless in 4D-space-time without begining or end. The dark energy would keep all universes in continually accelerated expansion to eventual fragmentation. Fragments would crash and merge into bangs, big or small, to form another generation of cousin universes. These scenarios might offer a clue to what was before the big bang.

  2. Michael Faraday and his contribution to anesthesia.

    PubMed

    Bergman, N A

    1992-10-01

    Michael Faraday (1791-1867) was a protégé of Humphry Davy. He became one of Davy's successors as Professor of Chemistry at the Royal Institution of Great Britain. Of Faraday's many brilliant discoveries in chemistry and physics, probably the best remembered today is his work on electromagnetic induction. Faraday's contribution to introduction of anesthesia was his published announcement in 1818 that inhalation of the vapor of ether produced the same effects on mentation and consciousness as the breathing of nitrous oxide. He most likely became familiar with the central nervous system effects of nitrous oxide through his association with Davy, an avid user of the gas. Sulfuric ether was a common, convenient, cheap, and easily available substance, in contrast to nitrous oxide, which required expensive, cumbersome, and probably not widely available apparatus for its production and administration. The capability for inhaling intoxicating vapors eventually became commonly available with the use of ether instead of the gas. The first surgical anesthetics were a consequence of the resulting student "ether frolics." The 1818 announcement on breathing ether vapor was published anonymously; however, notations in Faraday's handwriting in some of his personal books clearly establish Michael Faraday as the author of this brief communication. PMID:1416178

  3. New Horizons at Pluto

    NASA Technical Reports Server (NTRS)

    2007-01-01

    Artist's concept of the New Horizons spacecraft as it approaches Pluto and its largest moon, Charon, in July 2015. The craft's miniature cameras, radio science experiment, ultraviolet and infrared spectrometers and space plasma experiments will characterize the global geology and geomorphology of Pluto and Charon, map their surface compositions and temperatures, and examine Pluto's atmosphere in detail. The spacecraft's most prominent design feature is a nearly 7-foot (2.1-meter) dish antenna, through which it will communicate with Earth from as far as 4.7 billion miles (7.5 billion kilometers) away.

  4. Internet's critical path horizon

    NASA Astrophysics Data System (ADS)

    Valverde, S.; Solé, R. V.

    2004-03-01

    Internet is known to display a highly heterogeneous structure and complex fluctuations in its traffic dynamics. Congestion seems to be an inevitable result of user's behavior coupled to the network dynamics and it effects should be minimized by choosing appropriate routing strategies. But what are the requirements of routing depth in order to optimize the traffic flow? In this paper we analyse the behavior of Internet traffic with a topologically realistic spatial structure as described in a previous study [S.-H. Yook et al., Proc. Natl Acad. Sci. USA 99, 13382 (2002)]. The model involves self-regulation of packet generation and different levels of routing depth. It is shown that it reproduces the relevant key, statistical features of Internet's traffic. Moreover, we also report the existence of a critical path horizon defining a transition from low-efficient traffic to highly efficient flow. This transition is actually a direct consequence of the web's small world architecture exploited by the routing algorithm. Once routing tables reach the network diameter, the traffic experiences a sudden transition from a low-efficient to a highly-efficient behavior. It is conjectured that routing policies might have spontaneously reached such a compromise in a distributed manner. Internet would thus be operating close to such critical path horizon.

  5. Horizon thermodynamics and spacetime mappings

    NASA Astrophysics Data System (ADS)

    Faraoni, Valerio; Vitagliano, Vincenzo

    2014-03-01

    When black holes are dynamical, event horizons are replaced by apparent and trapping horizons. Conformal and Kerr-Schild transformations are widely used in relation to dynamical black holes, and we study the behavior under such transformations of quantities related to the thermodynamics of these horizons, such as the Misner-Sharp-Hernandez mass (internal energy), the Kodama vector, surface gravity, and temperature. The transformation properties are not those expected on the basis of naive arguments.

  6. HORIZON SENSING (PROPOSAL NO.51)

    SciTech Connect

    Larry G. Stolarczyk

    2003-07-01

    Real-time horizon sensing on continuous mining machines is becoming an industry tool. Installation and testing of production-grade Horizon Sensor (HS) systems continued this quarter at Monterey Coal Company (ExxonMobil), Mountain Coal Company West Elk Mine (Arch), and Ohio Valley Coal Company (OVC). Monitoring of system function, user experience, and mining benefits is ongoing. All horizon sensor components have finished MSHA (U.S.) and IEC (International) certification.

  7. HORIZON SENSING (PROPOSAL NO.51)

    SciTech Connect

    Larry G. Stolarczyk

    2003-07-30

    Real-time horizon sensing on continuous mining (CM) machines is becoming an industry tool. Installation and testing of production-grade Horizon Sensor (HS) systems has been ongoing this quarter at Monterey Coal Company (ExxonMobil), Mountain Coal Company West Elk Mine (Arch), Deserado Mining Company (Blue Mountain Energy), and The Ohio Valley Coal Company (TOVCC). Monitoring of system function, user experience, and mining benefits is ongoing. All horizon sensor components have finished MSHA (U.S.) and IEC (International) certification.

  8. Transverse deformations of extreme horizons

    NASA Astrophysics Data System (ADS)

    Li, Carmen; Lucietti, James

    2016-04-01

    We consider the inverse problem of determining all extreme black hole solutions to the Einstein equations with a prescribed near-horizon geometry. We investigate this problem by considering infinitesimal deformations of the near-horizon geometry along transverse null geodesics. We show that, up to a gauge transformation, the linearised Einstein equations reduce to an elliptic PDE for the extrinsic curvature of a cross-section of the horizon. We deduce that for a given near-horizon geometry there exists a finite dimensional moduli space of infinitesimal transverse deformations. We then establish a uniqueness theorem for transverse deformations of the extreme Kerr horizon. In particular, we prove that the only smooth axisymmetric transverse deformation of the near-horizon geometry of extreme Kerr, such that cross-sections of the horizon are marginally trapped surfaces, corresponds to that of the extreme Kerr black hole. Furthermore, we determine all smooth and biaxisymmetric transverse deformations of the near-horizon geometry of the five-dimensional extreme Myers-Perry black hole with equal angular momenta. We find a three parameter family of solutions such that cross-sections of the horizon are marginally trapped, which is more general than the known black hole solutions. We discuss the possibility that they correspond to new five-dimensional vacuum black holes.

  9. Technologies on the Horizon: Teachers Respond to the Horizon Report

    ERIC Educational Resources Information Center

    Hodges, Charles B.; Prater, Alyssa H.

    2014-01-01

    The purpose of this study was to investigate teachers' beliefs regarding the integration of technologies from the 2011 K-12 edition of the "Horizon Report" into their local, public school contexts. Teachers read the "Horizon Report" and then participated in an asynchronous, threaded discussion focusing on technologies they…

  10. Michael Maier--nine newly discovered letters.

    PubMed

    Lenke, Nils; Roudet, Nicolas; Tilton, Hereward

    2014-02-01

    The authors provide a transcription, translation, and evaluation of nine newly discovered letters from the alchemist Michael Maier (1568-1622) to Gebhardt Johann von Alvensleben (1576-1631), a noble landholder in the vicinity of Magdeburg. Stemming from the final year of his life, this correspondence casts new light on Maier's biography, detailing his efforts to secure patronage amid the financial crisis of the early Thirty Years' War. While his ill-fated quest to perfect potable gold continued to form the central focus of his patronage suits, Maier also offered his services in several arts that he had condemned in his printed works, namely astrology and "supernatural" magic. Remarks concerning his previously unknown acquaintance with Heinrich Khunrath call for a re-evaluation of Maier's negotiation of the discursive boundaries between Lutheran orthodoxy and Paracelsianism. The letters also reveal Maier's substantial contribution to a work previously ascribed solely to the English alchemist Francis Anthony. PMID:25241502

  11. Comments on Michael (1993): Establishing Operations

    PubMed Central

    Moore, J.

    2013-01-01

    The present comments concern Michael's concept of motivative variables, and the implications of that concept for our understanding of the nature of reinforcement as well as the extinction of responses maintained through positive and negative reinforcement. We note that both extinction and altering motivative variables decrease responding, but they do so differently. The former does so by discontinuing the response-reinforcer relation. The latter does so by altering the motivation to respond. We emphasize that we shouldn't conclude we have extinguished a response just because we have performed some operation that results in decreased responding. The difference is especially important for an understanding of how we might reduce maladaptive avoidance responses, such as found in phobias or obsessive-compulsive disorders. PMID:23814364

  12. STS-109 Crew Interviews: Michael J. Massimino

    NASA Technical Reports Server (NTRS)

    2002-01-01

    STS-109 Mission Specialist Michael J. Massimino is seen during a prelaunch interview. He answers questions about his inspiration to become an astronaut, his career path, and his most memorable experiences. He gives details on the mission's goals and objectives, which focus on the refurbishing of the Hubble Space Telescope, and his role in the mission. He explains the plans for the rendezvous of the Columbia Orbiter with the Hubble Space Telescope. He provides details and timelines for each of the planned Extravehicular Activities (EVAs), which include replacing the solar arrays, changing the Power Control Unit, installing the Advanced Camera for Surveys (ACS), and installing a new Cryocooler for the Near Infrared Camera and Multi-Object Spectrometer (NICMOS). He also describes the break-out plan in place for these spacewalks. The interview ends with Massimino explaining the details of a late addition to the mission's tasks, which is to replace a reaction wheel on the Hubble Space Telescope.

  13. Michael Faraday's Contributions to Archaeological Chemistry.

    PubMed

    Moshenska, Gabriel

    2015-08-01

    The analysis of ancient artefacts is a long but largely neglected thread within the histories of archaeology and chemistry. This paper examines Michael Faraday's contributions to this nascent field, drawing on his published correspondence and the works of his antiquarian collaborators, and focusing in particular on his analyses of Romano-British and ancient Egyptian artefacts. Faraday examined the materials used in ancient Egyptian mummification, and provided the first proof of the use of lead glazes on Roman ceramics. Beginning with an assessment of Faraday's personal interests and early work on antiquities with Humphry Davy, this paper critically examines the historiography of archaeological chemistry and attempts to place Faraday's work within its institutional, intellectual, and economic contexts. PMID:26307911

  14. Michael Young and the Curriculum Field in South Africa

    ERIC Educational Resources Information Center

    Hoadley, Ursula

    2015-01-01

    The paper addresses the question of what we should make of Michael Young's recent work with respect to curriculum theory by considering the particular case of South African curriculum reform. The paper thus traces two trajectories: the evolution of Michael Young's ideas over time and South African curriculum reform in the post-apartheid period.…

  15. Michael Naranjo, The Story of an American Indian.

    ERIC Educational Resources Information Center

    Nelson, Mary Carroll

    Michael Naranjo is a Pueblo Indian who, after much searching, has become a talented sculptor. The son of a Baptist minister, Michael grew up observing nature and exploring the countryside around Santa Clara (New Mexico), his birthplace. When he was nine, his family moved to Taos, where he watched the ceremonies of the Taos Pueblos with…

  16. 76 FR 10352 - Keyser, Michael J.; Notice of Filing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-24

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Keyser, Michael J.; Notice of Filing Take notice that on February 15, 2011, Michael J. Keyser submitted for filing, an application for authority to hold interlocking...

  17. Doing It All: Michael Sullivan--Weeks Public Library, NH

    ERIC Educational Resources Information Center

    Library Journal, 2005

    2005-01-01

    Michael Sullivan is a juggler--not a metaphorical one, a real one. He's also a library director, storyteller, competitive chess player, poet, speaker, and former children's librarian who continues to work with the kids in his community. This article summarizes the accomplishments and work of Michael Sullivan.

  18. Language and Intercultural Education: An Interview with Michael Byram

    ERIC Educational Resources Information Center

    Porto, Melina

    2013-01-01

    This article reports an interview with Michael Byram, Professor Emeritus, University of Durham in the United Kingdom, during his visit to Argentina in September 2011. Michael Byram is one of the main international referents in intercultural education. The interview addresses issues such as language education, intercultural and citizenship…

  19. Michael J. Meaney: Award for Distinguished Scientific Contributions

    ERIC Educational Resources Information Center

    American Psychologist, 2012

    2012-01-01

    Presents Michael J. Meaney as one of the winners of the American Psychological Association's Award for Distinguished Scientific Contributions (2012). Michael J. Meaney has taken the phenomenon of "handling" of newborn rats and opened a new area of investigation that has given new meaning to epigenetics via his work demonstrating transgenerational…

  20. Telescopic horizon scanning.

    PubMed

    Koenderink, Jan

    2014-12-20

    The problem of "distortionless" viewing with terrestrial telescopic systems (mainly "binoculars") remains problematic. The so called "globe effect" is only partially counteracted in modern designs. Theories addressing the phenomenon have never reached definitive closure. In this paper, we show that exact distortionless viewing with terrestrial telescopic systems is not possible in general, but that it is in principle possible in-very frequent in battle field and marine applications-the case of horizon scanning. However, this involves cylindrical optical elements. For opto-electronic systems, a full solution is more readily feasible. The solution involves a novel interpretation of the relevant constraints and objectives. For final design decisions, it is not necessary to rely on a corpus of psychophysical (or ergonomic) data, although one has to decide whether the instrument is intended as an extension of the eye or as a "pictorial" device. PMID:25608206

  1. Resolving Lifshitz Horizons

    SciTech Connect

    Harrison, Sarah; Kachru, Shamit; Wang, Huajia; /Stanford U., ITP /Stanford U., Phys. Dept. /SLAC

    2012-04-24

    Via the AdS/CFT correspondence, ground states of field theories at finite charge density are mapped to extremal black brane solutions. Studies of simple gravity + matter systems in this context have uncovered wide new classes of extremal geometries. The Lifshitz metrics characterizing field theories with non-trivial dynamical critical exponent z {ne} 1 emerge as one common endpoint in doped holographic toy models. However, the Lifshitz horizon exhibits mildly singular behaviour - while curvature invariants are finite, there are diverging tidal forces. Here we show that in some of the simplest contexts where Lifshitz metrics emerge, Einstein-Maxwell-dilaton theories, generic corrections lead to a replacement of the Lifshitz metric, in the deep infrared, by a re-emergent AdS{sub 2} x R{sup 2} geometry. Thus, at least in these cases, the Lifshitz scaling characterizes the physics over a wide range of energy scales, but the mild singularity is cured by quantum or stringy effects.

  2. Fluctuating black hole horizons

    NASA Astrophysics Data System (ADS)

    Mei, Jianwei

    2013-10-01

    In this paper we treat the black hole horizon as a physical boundary to the spacetime and study its dynamics following from the Gibbons-Hawking-York boundary term. Using the Kerr black hole as an example we derive an effective action that describes, in the large wave number limit, a massless Klein-Gordon field living on the average location of the boundary. Complete solutions can be found in the small rotation limit of the black hole. The formulation suggests that the boundary can be treated in the same way as any other matter contributions. In particular, the angular momentum of the boundary matches exactly with that of the black hole, suggesting an interesting possibility that all charges (including the entropy) of the black hole are carried by the boundary. Using this as input, we derive predictions on the Planck scale properties of the boundary.

  3. The New Horizons Spacecraft

    NASA Astrophysics Data System (ADS)

    Fountain, Glen H.; Kusnierkiewicz, David Y.; Hersman, Christopher B.; Herder, Timothy S.; Coughlin, Thomas B.; Gibson, William C.; Clancy, Deborah A.; Deboy, Christopher C.; Hill, T. Adrian; Kinnison, James D.; Mehoke, Douglas S.; Ottman, Geffrey K.; Rogers, Gabe D.; Stern, S. Alan; Stratton, James M.; Vernon, Steven R.; Williams, Stephen P.

    2008-10-01

    The New Horizons spacecraft was launched on 19 January 2006. The spacecraft was designed to provide a platform for seven instruments designated by the science team to collect and return data from Pluto in 2015. The design meets the requirements established by the National Aeronautics and Space Administration (NASA) Announcement of Opportunity AO-OSS-01. The design drew on heritage from previous missions developed at The Johns Hopkins University Applied Physics Laboratory (APL) and other missions such as Ulysses. The trajectory design imposed constraints on mass and structural strength to meet the high launch acceleration consistent with meeting the AO requirement of returning data prior to the year 2020. The spacecraft subsystems were designed to meet tight resource allocations (mass and power) yet provide the necessary control and data handling finesse to support data collection and return when the one-way light time during the Pluto fly-by is 4.5 hours. Missions to the outer regions of the solar system (where the solar irradiance is 1/1000 of the level near the Earth) require a radioisotope thermoelectric generator (RTG) to supply electrical power. One RTG was available for use by New Horizons. To accommodate this constraint, the spacecraft electronics were designed to operate on approximately 200 W. The travel time to Pluto put additional demands on system reliability. Only after a flight time of approximately 10 years would the desired data be collected and returned to Earth. This represents the longest flight duration prior to the return of primary science data for any mission by NASA. The spacecraft system architecture provides sufficient redundancy to meet this requirement with a probability of mission success of greater than 0.85. The spacecraft is now on its way to Pluto, with an arrival date of 14 July 2015. Initial in-flight tests have verified that the spacecraft will meet the design requirements.

  4. The Horizon Report. 2007 Edition

    ERIC Educational Resources Information Center

    New Media Consortium, 2007

    2007-01-01

    This fourth edition of the New Media Consortium's (NMC) annual "Horizon Report" describes the continuing work of the Horizon Project, a research-oriented effort that seeks to identify and describe emerging technologies likely to have a large impact on teaching, learning, or creative expression within higher education. Drawing on ongoing…

  5. The Horizon Report. 2006 Edition

    ERIC Educational Resources Information Center

    New Media Consortium, 2006

    2006-01-01

    This third edition of the New Media Consortium's (NMC) annual "Horizon Report" describes the continuing work of the Horizon Project, a research-oriented effort that seeks to identify and describe emerging technologies likely to have a large impact on teaching, learning, or creative expression within higher education. Drawing on ongoing discussions…

  6. The Horizon Report. 2004 Edition

    ERIC Educational Resources Information Center

    New Media Consortium, 2004

    2004-01-01

    This first edition of the New Media Consortium's (NMC) annual "Horizon Report" details findings of the Horizon Project, a research-oriented effort that seeks to identify and describe emerging technologies likely to have a large impact on teaching, learning, or creative expression within higher education. Drawing on an ongoing series of interviews…

  7. The Horizon Report. 2005 Edition

    ERIC Educational Resources Information Center

    New Media Consortium, 2005

    2005-01-01

    This second edition of the New Media Consortium's (NMC) annual "Horizon Report" describes the continuing work of the Horizon Project, a research-oriented effort that seeks to identify and describe emerging technologies likely to have a large impact on teaching, learning, or creative expression within higher education. Drawing on an ongoing series…

  8. Social pharmacology: expanding horizons.

    PubMed

    Maiti, Rituparna; Alloza, José Luis

    2014-01-01

    In the current modern and global society, social changes are in constant evolution due to scientific progress (technology, culture, customs, and hygiene) and produce the freedom in individuals to take decisions by themselves or with their doctors toward drug consumption. In the arena of marketed drug products which includes society, individual, administration, and pharmaceutical industry, the young discipline emerged is social pharmacology or sociopharmacology. This science arises from clinical pharmacology, and deals with different parameters, which are important in creating knowledge on marketed drugs. However, the scope of "social pharmacology" is not covered by the so-called "Phase IV" alone, but it is the science that handles the postmarketing knowledge of drugs. The social pharmacology studies the "life cycle" of any marketed pharmaceutical product in the social terrain, and evaluates the effects of the real environment under circumstances totally different in the drug development process. Therefore, there are far-reaching horizons, plural, and shared predictions among health professionals and other, for beneficial use of a drug, toward maximizing the benefits of therapy, while minimizing negative social consequences. PMID:24987168

  9. Social Pharmacology: Expanding horizons

    PubMed Central

    Maiti, Rituparna; Alloza, José Luis

    2014-01-01

    In the current modern and global society, social changes are in constant evolution due to scientific progress (technology, culture, customs, and hygiene) and produce the freedom in individuals to take decisions by themselves or with their doctors toward drug consumption. In the arena of marketed drug products which includes society, individual, administration, and pharmaceutical industry, the young discipline emerged is social pharmacology or sociopharmacology. This science arises from clinical pharmacology, and deals with different parameters, which are important in creating knowledge on marketed drugs. However, the scope of “social pharmacology” is not covered by the so-called “Phase IV” alone, but it is the science that handles the postmarketing knowledge of drugs. The social pharmacology studies the “life cycle” of any marketed pharmaceutical product in the social terrain, and evaluates the effects of the real environment under circumstances totally different in the drug development process. Therefore, there are far-reaching horizons, plural, and shared predictions among health professionals and other, for beneficial use of a drug, toward maximizing the benefits of therapy, while minimizing negative social consequences. PMID:24987168

  10. Near-horizon Kerr magnetosphere

    NASA Astrophysics Data System (ADS)

    Gralla, Samuel E.; Lupsasca, Alexandru; Strominger, Andrew

    2016-05-01

    We exploit the near-horizon conformal symmetry of rapidly spinning black holes to determine universal properties of their magnetospheres. Analytic expressions are derived for the limiting form of the magnetosphere in the near-horizon region. The symmetry is shown to imply that the black hole Meissner effect holds for free Maxwell fields but is generically violated for force-free fields. We further show that in the extremal limit, near-horizon plasma particles are infinitely boosted relative to accretion flow. Active galactic nuclei powered by rapidly spinning black holes are therefore natural sites for high-energy particle collisions.

  11. Race, punishment, and the Michael Vick experience.

    PubMed

    Piquero, Alex R; Piquero, Nicole Leeper; Gertz, Marc; Baker, Thomas; Batton, Jason; Barnes, J C

    2011-01-01

    Objective. The relationship between race and crime has been contentious, focusing primarily on offending and incarceration patterns among minorities. There has been some limited work on public perceptions of criminal punishment, and findings show that while minorities believe in the role and rule of law, they simultaneously perceive the justice system as acting in a biased and/or unfair manner. Two limitations have stalled this literature. First, research has focused mainly on criminal punishments to the neglect of noncriminal punishments. Second, most studies have not examined whether race remains salient after considering other demographic variables or discrimination and legitimacy attitudes.Methods. Using data from 400 adults, we examine how race affects perceptions of criminal punishment and subsequent reinstatement into the National Football League in the case of Michael Vick, a star professional quarterback who pled guilty to charges of operating an illegal dog-fighting ring.Results. Findings show that whites are more likely to view Vick's punishment as too soft and that he should not be reinstated, while nonwhites had the opposite views. Race remained significant after controlling for other variables believed to be related to punishment perceptions.Conclusion. Attitudes toward both criminal punishment and NFL reinstatement vary across race such that there exists important divides in how individuals perceive the system meting out punishment and subsequently reintegrating offenders back into society. These results underscore that white and nonwhites perceive the law and its administration differently. PMID:21919273

  12. Obituary: Michael John Klein, 1940-2005

    NASA Astrophysics Data System (ADS)

    Gulkis, Samuel

    2006-12-01

    Michael John Klein died on 14 May 2005 at home in South Pasadena, California. The cause of death was tongue cancer that metastasized to the lungs. He was a non-smoker. Mike was a passionate radio astronomer, a trusted astronomical observer, an educator and a family man. Mike was born on 19 January 1940 in Ames, Iowa, the son of Florence Marie (Graf) and Fred Michael Klein. His mother was a homemaker, and his father was a banker. Mike had two older sisters, Lois Jean (Klein) Flauher and Marilyn June (Klein) Griffin. In 1962, Mike married his high school sweetheart Barbara Dahlberg, who survives him along with their three children, Kristin Marie (Klein) Shields, Michael John Klein Jr., Timothy Joel Klein, and six grandchildren. Mike developed a love for astronomy early in his life, and credited an early morning, newspaper-delivery route that he had at age twelve, which took him outside well before sunrise. He told family members that as he walked along his route, he stared into the sky and wondered what everything was. He studied sky charts, located stars, and began to understand how the planets shifted their positions relative to the stars each day. Another big influence in Mike's life was his brother in-law, Jim Griffin. Jim helped Mike understand that his passion for science did not have to remain a hobby, but could and should become a career. Jim's encouragement led Mike to attend Iowa State University in Ames, where he earned a BS in electrical engineering in 1962. Mike then started graduate school in electrical engineering at Michigan State, but after one semester transferred to the University of Michigan, Ann Arbor, where he earned an MS (1966) and PhD (1968) in astronomy. His doctoral dissertation, under the direction of Professor Fred Haddock, was based on extensive observations of the planets and examined the physical and thermal properties of planetary atmospheres and surfaces. Mike was awarded a Resident Research Associate position at JPL by the National

  13. Two papers by Michael Fordham (d.1995).

    PubMed

    Astor, James

    2010-11-01

    The Journal has decided to publish a selection of previously unpublished papers from the Michael Fordham archives, which are being prepared for publication by James Astor and Elizabeth Urban, and of which the two papers published here are the first, both dating from the 1950s. 'Analyst and Priest' seems to be addressed to an audience of mainly religious people who are interested in the relation between psychology and religion and to whom Fordham is introducing some basic Jungian concepts and ways of thinking. The analyst in this lecture is the advocate of a new science, the priest an established figure with a role in society and rituals to perform. As the paper progresses he refines the differences between priest and analyst in terms of individual development versus a philosophy of life. The paper ends with a plea for co-operation between priest and analyst. 'Analyst and Scientist' was a radio talk given in 1956. In this paper Fordham makes the case for paying attention to the irrational. He draws support from Pauli and Polanyi. His theme is to show the scientific value of the subjective. From this he describes the scientific basis for Jung's comparative method and consequently of archetypal psychology. PMID:20961314

  14. HORIZON SENSING (PROPOSAL No.51)

    SciTech Connect

    Larry G. Stolarczyk, Sc.D.

    2002-04-30

    Real-time horizon sensing on continuous mining machines is becoming an industry tool. Installation and testing of production-grade HS systems has been ongoing this quarter at Monterey Coal Company (EXXON), FMC Trona, Twentymile Coal Company (RAG America), and SASOL Coal. Detailed monitoring of system function, user experience, and mining benefits is ongoing. All horizon sensor components have finished MSHA (U.S.) and IEC (International) certification.

  15. Michael Akam and the rise of evolutionary developmental biology.

    PubMed

    Stern, David L; Dawes-Hoang, Rachel E

    2010-01-01

    Michael Akam has been awarded the 2007 Kowalevsky medal for his many research accomplishments in the area of evolutionary developmental biology. We highlight three tributaries of Michaels contribution to evolutionary developmental biology. First, he has made major contributions to our understanding of development of the fruit fly, Drosophila melanogaster. Second, he has maintained a consistent focus on several key problems in evolutionary developmental biology, including the evolving role of Hox genes in arthropods and, more recently, the evolution of segmentation mechanisms. Third, Michael has written a series of influential reviews that have integrated progress in developmental biology into an evolutionary perspective. Michael has also made a large impact on the field through his effective mentorship style, his selfless promotion of younger colleagues, and his leadership of the University Museum of Zoology at Cambridge and the European community of evolutionary developmental biologists. PMID:20209429

  16. Satellite Sees Hurricane Leslie and Tropical Storm Michael in Atlantic

    NASA Video Gallery

    A movie of satellite observations from Sept. 2-5, 2012, shows Leslie strengthen into a Hurricane on September 5 as it nears Bermuda, and tiny Tropical Storm Michael in the central Atlantic Ocean. T...

  17. Michael López-Alegría Profile

    NASA Video Gallery

    Meet NASA astronaut Michael López-Alegría, a veteran of four spaceflights. He has logged over 257 days in space and performed 10 spacewalks. Learn what inspired him to become such a successful astr...

  18. Astronaut Michael Collins inspects camera during prelaunch activity

    NASA Technical Reports Server (NTRS)

    1966-01-01

    Astronaut Michael Collins (left), Gemini 10 prime crew pilot, inspects camera during prelaunch activity at Cape Kennedy, Florida. In center background is Dr. Donald K. Slayton, Manned Spacecraft Center (MSC) Director of Flight Crew Operations.

  19. Principles of Chemistry (by Michael Munowitz)

    NASA Astrophysics Data System (ADS)

    Kovac, Reviewed By Jeffrey

    2000-05-01

    At a time when almost all general chemistry textbooks seem to have become commodities designed by marketing departments to offend no one, it is refreshing to find a book with a unique perspective. Michael Munowitz has written what I can only describe as a delightful chemistry book, full of conceptual insight, that uses a novel and interesting pedagogic strategy. This is a book that has much to recommend it. This is the best-written general chemistry book I have ever read. An editor with whom I have worked recently remarked that he felt his job was to help authors make their writing sing. Well, the writing in Principles of Chemistry sings with the full, rich harmonies and creative inventiveness of the King's Singers or Chanticleer. Here is the first sentence of the introduction: "Central to any understanding of the physical world is one discovery of paramount importance, a truth disarmingly simple yet profound in its implications: matter is not continuous." This is prose to be savored and celebrated. Principles of Chemistry has a distinct perspective on chemistry: the perspective of the physical chemist. The focus is on simplicity, what is common about molecules and reactions; begin with the microscopic and build bridges to the macroscopic. The author's perspective is clear from the organization of the book. After three rather broad introductory chapters, there are four chapters that develop the quantum mechanical theory of atoms and molecules, including a strong treatment of molecular orbital theory. Unlike many books, Principles of Chemistry presents the molecular orbital approach first and introduces valence bond theory later only as an approximation for dealing with more complicated molecules. The usual chapters on descriptive inorganic chemistry are absent (though there is an excellent chapter on organic and biological molecules and reactions as well as one on transition metal complexes). Instead, descriptive chemistry is integrated into the development of

  20. Deepwater Horizon Situation Report #5

    SciTech Connect

    2010-06-10

    At approximately 11:00 pm EDT April 20, 2010 an explosion occurred aboard the Deepwater Horizon mobile offshore drilling unit (MODU) located 52 miles Southeast of Venice, LA and 130 miles southeast of New Orleans, LA. The MODU was drilling an exploratory well and was not producing oil at the time of the incident. The Deepwater Horizon MODU sank 1,500 feet northwest of the well site. Detailed information on response and recovery operations can be found at: http://www.deepwaterhorizonresponse.com/go/site/2931/

  1. Principles of Chemistry (by Michael Munowitz)

    NASA Astrophysics Data System (ADS)

    Kovac, Reviewed By Jeffrey

    2000-05-01

    At a time when almost all general chemistry textbooks seem to have become commodities designed by marketing departments to offend no one, it is refreshing to find a book with a unique perspective. Michael Munowitz has written what I can only describe as a delightful chemistry book, full of conceptual insight, that uses a novel and interesting pedagogic strategy. This is a book that has much to recommend it. This is the best-written general chemistry book I have ever read. An editor with whom I have worked recently remarked that he felt his job was to help authors make their writing sing. Well, the writing in Principles of Chemistry sings with the full, rich harmonies and creative inventiveness of the King's Singers or Chanticleer. Here is the first sentence of the introduction: "Central to any understanding of the physical world is one discovery of paramount importance, a truth disarmingly simple yet profound in its implications: matter is not continuous." This is prose to be savored and celebrated. Principles of Chemistry has a distinct perspective on chemistry: the perspective of the physical chemist. The focus is on simplicity, what is common about molecules and reactions; begin with the microscopic and build bridges to the macroscopic. The author's perspective is clear from the organization of the book. After three rather broad introductory chapters, there are four chapters that develop the quantum mechanical theory of atoms and molecules, including a strong treatment of molecular orbital theory. Unlike many books, Principles of Chemistry presents the molecular orbital approach first and introduces valence bond theory later only as an approximation for dealing with more complicated molecules. The usual chapters on descriptive inorganic chemistry are absent (though there is an excellent chapter on organic and biological molecules and reactions as well as one on transition metal complexes). Instead, descriptive chemistry is integrated into the development of

  2. NIF featured on BBC "Horizon"

    ScienceCinema

    Brian Cox

    2010-09-01

    The National Ignition Facility, the world's largest laser system, located at Lawrence Livermore National Laboratory, was featured in the BBC broadcast "Horizon" hosted by physicist Brian Cox. Here is the NIF portion of the program, which was entitled "Can We Make A Star On Earth?" This video is used with the express permission of the BBC.

  3. Common Ground: Expanding Our Horizons.

    ERIC Educational Resources Information Center

    McDevitt, Michele J.

    In "Common Ground: Dialogue, Understanding, and the Teaching of Composition," Kurt Spellmeyer seeks to familiarize students and teachers with the linguistic and cultural no-man's-land separating them. Reinstating the value of two writing conventions often used by traditional students--expressive and commonplaces--can help expand on the horizons of…

  4. New Horizons in Education, 2000.

    ERIC Educational Resources Information Center

    Ho, Kwok Keung, Ed.

    2000-01-01

    This document contains the May and November 2000 issues of "New Horizons in Education," with articles in English and Chinese. The May issue includes the following articles: "A Key to Successful Environmental Education: Teacher Trainees' Attitude, Behaviour, and Knowledge" (Kevin Chung Wai Lui, Eric Po Keung Tsang, Sing Lai Chan); "Critical…

  5. New Horizons Mission to Pluto

    NASA Technical Reports Server (NTRS)

    Delgado, Luis G.

    2011-01-01

    This slide presentation reviews the trajectory that will take the New Horizons Mission to Pluto. Included are photographs of the spacecraft, the launch vehicle, the assembled vehicle as it is being moved to the launch pad and the launch. Also shown are diagrams of the assembled parts with identifying part names.

  6. NIF featured on BBC "Horizon"

    SciTech Connect

    Brian Cox

    2010-01-12

    The National Ignition Facility, the world's largest laser system, located at Lawrence Livermore National Laboratory, was featured in the BBC broadcast "Horizon" hosted by physicist Brian Cox. Here is the NIF portion of the program, which was entitled "Can We Make A Star On Earth?" This video is used with the express permission of the BBC.

  7. Michael hydratase alcohol dehydrogenase or just alcohol dehydrogenase?

    PubMed Central

    2014-01-01

    The Michael hydratase – alcohol dehydrogenase (MhyADH) from Alicycliphilus denitrificans was previously identified as a bi-functional enzyme performing a hydration of α,β-unsaturated ketones and subsequent oxidation of the formed alcohols. The investigations of the bi-functionality were based on a spectrophotometric assay and an activity staining in a native gel of the dehydrogenase. New insights in the recently discovered organocatalytic Michael addition of water led to the conclusion that the previously performed experiments to identify MhyADH as a bi-functional enzyme and their results need to be reconsidered and the reliability of the methodology used needs to be critically evaluated. PMID:24949265

  8. Obituary: Michael John Seaton, 1923-2007

    NASA Astrophysics Data System (ADS)

    Pradhan, Anil; Nahar, Sultana

    2007-12-01

    Professor Michael John Seaton, hailed as the "Father of Atomic Astrophysics," passed away on May 29, 2007. He was one of the few Honorary Fellows of both the American Astronomical Society and the American Physical Society, so honored for his monumental contributions to both physics and astronomy. Mike Seaton was born on January 16, 1923 in Bristol, England. He attended Wallington County High School. But his leftist political activities, even at that stage, led to his expulsion, though he was eventually allowed to matriculate. He enlisted in the Royal Air Force as a navigator during the Second World War, and flew many dangerous missions. His legendary concentration and precision are reflected in the following anecdote. Once after a bombing mission his aircraft was lost in fog over the Alps. Seaton calculated the position and coordinates in flight to guide the aircraft. When the fog lifted, the crew found themselves flying perilously close to the mountains, but made it safely back. His associates often said, "A Seaton calculation is carried out as if his life depended on it." After the War he was admitted to University College London (UCL) as an undergraduate. Thereafter, he spent all of his professional career at UCL. Seaton received his Batchelor's degree in 1948, and his Ph.D. in 1951. His tenure at UCL coincided with the golden age of atomic astrophysics, for he was largely responsible for it. Seaton was elected Fellow of the Royal Society in 1967, and as President of the Royal Astronomical Society (RAS) in 1978. He was the recipient of an Honorary Doctorate from the Observatoire de Paris, an Honorary D.Sc. from the Queen's University of Belfast, the Gold Medal for Astronomy by the RAS, the Guthrie Medal by the Institute of Physics, the Royal Society Hughes award for lifetime work by the RAS, and several other prestigious awards. Nevertheless, as Alex Dalgarno recently remarked, Seaton was not part of the establishment because he chose not to be. Though rooted in

  9. The Malcolm horizon: History and future

    NASA Technical Reports Server (NTRS)

    Malcolm, R.

    1984-01-01

    The development of the Malcolm Horizon, a peripheral vision horizon used in flight simulation, is discussed. A history of the horizon display is presented as well as a brief overview of vision physiology, and the role balance plays is spatial orientation. Avenues of continued research in subconscious cockpit instrumentation are examined.

  10. Michael Young's "The Rise of the Meritocracy": A Philosophical Critique

    ERIC Educational Resources Information Center

    Allen, Ansgar

    2011-01-01

    This paper examines Michael Young's 1958 dystopia, "The Rise of the Meritocracy". In this book, the word "meritocracy" was coined and used in a pejorative sense. Today, however, meritocracy represents a positive ideal against which we measure the justice of our institutions. This paper argues that, when read in the twenty-first century, Young's…

  11. The Epistemic Criterion: A Response to Michael Hand

    ERIC Educational Resources Information Center

    Cooling, Trevor

    2014-01-01

    This article is a response to Michael Hand's critique in this issue of my response to his use of the epistemic criterion as the sole means for identifying whether or not an issue should be identified as controversial. I argue that he has misunderstood my intention in suggesting that I was seeking to replace the epistemic criterion. Rather my…

  12. Insight into the Mechanism of the Michael Reaction.

    PubMed

    Giraldo, Carolina; Gómez, Sara; Weinhold, Frank; Restrepo, Albeiro

    2016-07-01

    The mechanism for the nucleophilic addition step of the Michael reaction between methanethiol as a model Michael donor and several α-substituted methyl acrylates (X=F, Cl, Me, H, CN, NO2 ) as model Michael acceptors is described in detail. We suggest a novel way to condense electrophilic Fukui functions at specific atoms in terms of the contributions from the atomic orbitals to the LUMO or, more generally, to the orbital controlling the reaction. This procedure correctly associates activation energies to local electrophilic Fukui indices for the cases treated in this work. The calculated reaction barriers strongly depend on the nature of the substituent. As a general rule, activation energies are governed by structural changes, although electronic factors are significant for electron-withdrawing groups. Nucleophilic addition to Michael receptors is best described as a highly nonsynchronous process, in which the geometry of the transition state comprises a nonplanar six-membered ring. Formation of the S⋅⋅⋅C bond, which defines the interaction between the reactants, progresses ahead of all other primitive processes in the early stages of the transformation. In view of our results, we postulate that highly complex chemical reactions, as is the case for the nucleophilic addition step studied herein, that involve cleavage/formation of a total of six bonds, lower their activation energies by favoring nonsynchronicity, that is, for these types of systems, primitive changes should advance at different rates. PMID:26990819

  13. Michael Hand, Indoctrination and the Inculcation of Belief

    ERIC Educational Resources Information Center

    Tan, Charlene

    2004-01-01

    In 'Religious Upbringing Reconsidered,' Michael Hand revisits the debate on the right of parents to give their children a religious upbringing in a liberal context. According to him, the logical difficulty lies in the fact that parents cannot both impart religious beliefs and avoid indoctrination. While Peter Gardner and Jim Mackenzie have…

  14. The Holocaust and Education: An Interview with Michael Berenbaum.

    ERIC Educational Resources Information Center

    Goldberg, Mark

    1997-01-01

    In January 1997, Michael Berenbaum became president and chief executive officer of Survivors of the Shoah Visual History Foundation, the organization established by filmmaker Steven Spielberg after completing "Schindler's List." Since 1994, the foundation has been recording eyewitness testimony on the Holocaust. Berenbaum's mandate is to share…

  15. HEADSTONES OF BERNARD AND MICHAEL JODD, FATHERANDSON CIVILIANS RESPONSIBLE FOR ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    HEADSTONES OF BERNARD AND MICHAEL JODD, FATHER-AND-SON CIVILIANS RESPONSIBLE FOR CONSTRUCTION OF BRICK PERIMETER WALL WHO DIED OF YELLOW FEVER DURING WALL CONSTRUCTION. VIEW TO WEST. - Baton Rouge National Cemetery, 220 North 19th Street, Baton Rouge, East Baton Rouge Parish, LA

  16. Writing before the Letter: Reading Michael Ondaatje's "Handwriting"

    ERIC Educational Resources Information Center

    Festino, Cielo G.

    2006-01-01

    The purpose of this paper is to offer a reading of "Handwriting", the book of poems by the Canadian-Sri Lankan author, Michael Ondaatje, in which he recovers the recent and ancient cultural history of the island through his reading of different types of scripts and languages. The texts that Ondaatje rewrites in his poems are visual, written, oral…

  17. On Happiness and High Achievement: An Interview with Michael Thompson

    ERIC Educational Resources Information Center

    National Association of Independent Schools (NAIS) (NJ), 2006

    2006-01-01

    Michael G. Thompson knows independent schools. He attended them in elementary and secondary school, and has worked in them as a psychologist. He consults with more than 30 schools a year, addressing a myriad of issues related to complex human interaction. He has written often in "Independent School" about everything from understanding the social…

  18. "No More Excuses": Michael M. Crow on Analytics

    ERIC Educational Resources Information Center

    Crow, Michael M.

    2012-01-01

    Michael M. Crow became the 16th president of Arizona State University in July 2002, with the goal of transforming ASU into what he calls a "New American University"--an institution combining the highest levels of academic excellence, inclusiveness to a broad demographic, and maximum societal impact. His view included increasing graduate numbers,…

  19. Aza-Michael Reaction for an Undergraduate Organic Chemistry Laboratory

    ERIC Educational Resources Information Center

    Nigam, Manisha; Rush, Brittney; Patel, Jay; Castillo, Raul; Dhar, Preeti

    2016-01-01

    A green, aza-Michael reaction is described that can be used to teach undergraduate students conjugate addition of nitrogen nucleophile to an a,ß-unsaturated ester. Students analyze spectral data of the product obtained from the assigned reaction to determine product structure and propose the mechanism of its formation. The experiment requires…

  20. A Good Time: A Conversation with C. Michael Nelson

    ERIC Educational Resources Information Center

    Zabel, Robert; Kaff, Marilyn; Teagarden, Jim

    2015-01-01

    C. Michael Nelson began his special education career as a teacher of adolescents with learning and behavior disorders. He has worked as a child psychologist and as a professor with the Department of Special Education and Rehabilitation Counseling at the University of Kentucky. He coordinated the graduate Personnel Preparation Program for Teachers…

  1. Michael Young and the Politics of the School Curriculum

    ERIC Educational Resources Information Center

    Morgan, John

    2015-01-01

    Michael Young's work is central to debates about knowledge and the school curriculum. In recent years he has renounced his early argument that school subjects represent the "knowledge of the powerful", arguing instead that access and equality for all students are dependent on ensuring that all get access to "powerful…

  2. Michael Young, Knowledge and Curriculum: An International Dialogue

    ERIC Educational Resources Information Center

    Deng, Zongyi

    2015-01-01

    This issue of the "Journal of Curriculum Studies" presents a symposium on the recent work of Michael Young. Contemporary curriculum theory has little specific to say about how knowledge is selected, organized and transformed into curriculum content for teaching and learning. Over the last two decades, Young has taken a rather different…

  3. Proof Positive: Q&A with Michael Fullan

    ERIC Educational Resources Information Center

    Crow, Tracy

    2009-01-01

    This article presents an interview with Michael Fullan, an internationally recognized expert in educational change. A prolific writer and speaker, Fullan has worked in schools and educational systems around the world, including his home province of Ontario, Canada. He partners with a variety of projects designed to engineer school improvement and…

  4. Perfil de Michael López- Alegría

    NASA Video Gallery

    Conoce al astronauta de la NASA Michael López-Alegría, veterano de cuatro vuelos espaciales. Lleva registrados 257 días en el espacio y llevó a cabo 10 paseos espaciales. Conoce lo que lo inspiró a...

  5. The origins of Michael Conrad's research programs (1964-1979).

    PubMed

    Pattee, H H

    2002-01-01

    This paper summarizes Michael Conrad's academic and professional career from the time he began his Ph.D. studies in 1964 to his appointment at Wayne State University in 1979. It describes the origins of several of his major research interests and presents a personal evaluation of how this early work continues to be of fundamental importance. PMID:11755483

  6. Tweeting Prayers and Communicating Grief over Michael Jackson Online

    ERIC Educational Resources Information Center

    Sanderson, Jimmy; Cheong, Pauline Hope

    2010-01-01

    Death and bereavement are human experiences that new media helps facilitate alongside creating new social grief practices that occur online. This study investigated how people's postings and tweets facilitated the communication of grief after pop music icon Michael Jackson died. Drawing on past grief research, religion, and new media studies, a…

  7. Goodwill Ambassador: Michael Neubert--Library of Congress, Washington, DC

    ERIC Educational Resources Information Center

    Library Journal, 2004

    2004-01-01

    This article details the work of Michael Neubert from the Library of Congress. It briefly discusses his interest in Russian studies and how it originated. It then discusses that when he received his M.A. in Soviet Studies he was not sure how he would make a living--until he read about the job opportunities for area studies librarians.

  8. Michael Polanyi on the Education and Knowledge of Scientists.

    ERIC Educational Resources Information Center

    Jacobs, Struan

    2000-01-01

    Explains why teachers addressing the nature of science should know the work of Michael Polanyi. Outlines Polanyi's intellectual career and examines his ideas on the education of scientists, research, and knowledge. Polanyi presaged Kuhn, Feyerabend, and the constructivists, yet insisted that science produces true knowledge about reality. (Contains…

  9. Michael Polanyi: The University and the Technological State.

    ERIC Educational Resources Information Center

    Price, G. L.

    1978-01-01

    The problem of the intellectual independence of the university within a technologically oriented society was one of the problems which motivated Michael Polanyi's inquiry into the foundations of knowledge. The key elements of his resultant attempt to supersede objectivist accounts of science are isolated, and evaluated. (Editor/RK)

  10. Michael Stipe Wake-Up Song and Greeting

    NASA Video Gallery

    The four astronauts of the final space shuttle mission are greeted by R.E.M. front man Michael Stipe and the group’s hit, "Man on the Moon" to begin Flight Day 7. On recording this song for the A...

  11. Reading Michael Apple--The Sociological Imagination at Work

    ERIC Educational Resources Information Center

    Ball, Stephen J.

    2007-01-01

    This article discusses Michael Apple's contribution to the sociology of education and education policy analysis and the politics of education. It focuses on ways of "reading" Apple as an intellectual and an activist and looks at the trajectory of his work over a long and illustrious career.

  12. Developing Successful Retention Programs: An Interview with Michael Hovland.

    ERIC Educational Resources Information Center

    Kluepfel, Gail A.; Hovland, Michael

    1994-01-01

    Michael Hovland, the senior consultant at Noel-Levitz Centers, responds to questions about summer bridge programs, first-year seminar programs, Rutgers' retention model, faculty reactions to retention programs, the impact of retention programs on institutional mission, administrative involvement in retention, student assessment, retention efforts…

  13. Fermion tunneling from dynamical horizons

    NASA Astrophysics Data System (ADS)

    Di Criscienzo, R.; Vanzo, L.

    2008-06-01

    The instability against emission of fermionic particles by the trapping horizon of an evolving black hole is analyzed and confirmed using the Hamilton-Jacobi tunneling method. This method automatically selects one special expression for the surface gravity of a changing horizon. The results also apply to point masses embedded in an expanding universe. As a bonus of the tunneling method, we gain the insight that the surface gravity still defines a temperature parameter as long as the evolution is sufficiently slow that the black-hole pass through a sequence of quasi-equilibrium states, and that black holes should be semi-classically unstable even in a hypothetical world without bosonic fields.

  14. Expert system for predicting reaction conditions: the Michael reaction case.

    PubMed

    Marcou, G; Aires de Sousa, J; Latino, D A R S; de Luca, A; Horvath, D; Rietsch, V; Varnek, A

    2015-02-23

    A generic chemical transformation may often be achieved under various synthetic conditions. However, for any specific reagents, only one or a few among the reported synthetic protocols may be successful. For example, Michael β-addition reactions may proceed under different choices of solvent (e.g., hydrophobic, aprotic polar, protic) and catalyst (e.g., Brønsted acid, Lewis acid, Lewis base, etc.). Chemoinformatics methods could be efficiently used to establish a relationship between the reagent structures and the required reaction conditions, which would allow synthetic chemists to waste less time and resources in trying out various protocols in search for the appropriate one. In order to address this problem, a number of 2-classes classification models have been built on a set of 198 Michael reactions retrieved from literature. Trained models discriminate between processes that are compatible and respectively processes not feasible under a specific reaction condition option (feasible or not with a Lewis acid catalyst, feasible or not in hydrophobic solvent, etc.). Eight distinct models were built to decide the compatibility of a Michael addition process with each considered reaction condition option, while a ninth model was aimed to predict whether the assumed Michael addition is feasible at all. Different machine-learning methods (Support Vector Machine, Naive Bayes, and Random Forest) in combination with different types of descriptors (ISIDA fragments issued from Condensed Graphs of Reactions, MOLMAP, Electronic Effect Descriptors, and Chemistry Development Kit computed descriptors) have been used. Models have good predictive performance in 3-fold cross-validation done three times: balanced accuracy varies from 0.7 to 1. Developed models are available for the users at http://infochim.u-strasbg.fr/webserv/VSEngine.html . Eventually, these were challenged to predict feasibility conditions for ∼50 novel Michael reactions from the eNovalys database (originally

  15. Penrose inequality and apparent horizons

    SciTech Connect

    Ben-Dov, Ishai

    2004-12-15

    A spherically symmetric spacetime is presented with an initial data set that is asymptotically flat, satisfies the dominant energy condition, and such that on this initial data M<{radical}(A/16{pi}), where M is the total mass and A is the area of the apparent horizon. This provides a counterexample to a commonly stated version of the Penrose inequality, though it does not contradict the true Penrose inequality.

  16. New Horizons Tracks an Asteroid

    NASA Technical Reports Server (NTRS)

    2007-01-01

    The two 'spots' in this image are a composite of two images of asteroid 2002 JF56 taken on June 11 and June 12, 2006, with the Multispectral Visible Imaging Camera (MVIC) component of the New Horizons Ralph imager. In the bottom image, taken when the asteroid was about 3.36 million kilometers (2.1 million miles) away from the spacecraft, 2002 JF56 appears like a dim star. At top, taken at a distance of about 1.34 million kilometers (833,000 miles), the object is more than a factor of six brighter. The best current, estimated diameter of the asteroid is approximately 2.5 kilometers.

    The asteroid observation was a chance for the New Horizons team to test the spacecraft's ability to track a rapidly moving object. On June 13 New Horizons came to within about 102,000 kilometers of the small asteroid, when the spacecraft was nearly 368 million kilometers (228 million miles) from the Sun and about 273 million kilometers (170 million miles) from Earth.

  17. Domino Michael-Michael and Aldol-Aldol Reactions: Diastereoselective Synthesis of Functionalized Cyclohexanone Derivatives Containing Quaternary Carbon Center.

    PubMed

    Ghorai, Manas K; Halder, Sandipan; Das, Subhomoy

    2015-10-01

    A simple strategy for the synthesis of highly functionalized cyclohexanone derivatives containing an all-carbon quaternary center from α-(aryl/alkyl)methylidene-β-keto esters or β-diketones via a K-enolate mediated domino Michael-Michael reaction sequence with moderate to good yield and excellent diastereoselectivity (de > 99%) is described. Interestingly, Li-base mediated reaction of α-arylmethylidene-β-diketones affords functionalized 3,5-dihydroxy cyclohexane derivatives as the kinetically controlled products via a domino aldol-aldol reaction sequence with excellent diastereoselectivity. Li-enolates of the β-keto esters or β-diketones undergo facile domino Michael-Michael reaction with nitro-olefins to afford the corresponding nitrocyclohexane derivatives in good yields and excellent diastereoselectivity (de > 99%). The formation of the products and the observed stereoselectivity were explained by plausible mechanisms and supported by extensive computational study. An asymmetric version of the protocol was explored with (L)-menthol derived nonracemic substrates, and the corresponding nonracemic cyclohexanone derivatives containing an all-carbon quaternary center were obtained with excellent stereoselectivity (de, ee > 99%). PMID:26334184

  18. New Horizons Launch Contingency Effort

    NASA Astrophysics Data System (ADS)

    Chang, Yale; Lear, Matthew H.; McGrath, Brian E.; Heyler, Gene A.; Takashima, Naruhisa; Owings, W. Donald

    2007-01-01

    On 19 January 2006 at 2:00 PM EST, the NASA New Horizons spacecraft (SC) was launched from the Cape Canaveral Air Force Station (CCAFS), FL, onboard an Atlas V 551/Centaur/STAR™ 48B launch vehicle (LV) on a mission to explore the Pluto Charon planetary system and possibly other Kuiper Belt Objects. It carried a single Radioisotope Thermoelectric Generator (RTG). As part of the joint NASA/US Department of Energy (DOE) safety effort, contingency plans were prepared to address the unlikely events of launch accidents leading to a near-pad impact, a suborbital reentry, an orbital reentry, or a heliocentric orbit. As the implementing organization. The Johns Hopkins University Applied Physics Laboratory (JHU/APL) had expanded roles in the New Horizons launch contingency effort over those for the Cassini mission and Mars Exploration Rovers missions. The expanded tasks included participation in the Radiological Control Center (RADCC) at the Kennedy Space Center (KSC), preparation of contingency plans, coordination of space tracking assets, improved aerodynamics characterization of the RTG's 18 General Purpose Heat Source (GPHS) modules, and development of spacecraft and RTG reentry breakup analysis tools. Other JHU/APL tasks were prediction of the Earth impact footprints (ElFs) for the GPHS modules released during the atmospheric reentry (for purposes of notification and recovery), prediction of the time of SC reentry from a potential orbital decay, pre-launch dissemination of ballistic coefficients of various possible reentry configurations, and launch support of an Emergency Operations Center (EOC) on the JHU/APL campus. For the New Horizons launch, JHU/APL personnel at the RADCC and at the EOC were ready to implement any real-time launch contingency activities. A successful New Horizons launch and interplanetary injection precluded any further contingency actions. The New Horizons launch contingency was an interagency effort by several organizations. This paper

  19. 76 FR 58264 - Michael J. Donahue; Notice of Termination of Exemption by Implied Surrender and Soliciting...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-20

    ... Energy Regulatory Commission Michael J. Donahue; Notice of Termination of Exemption by Implied Surrender...: Michael J. Donahue. e. Name and Location of Project: The Fairbanks Mill Project is located on the Sleeper... Information: Mr. Michael J. Donahue, Route 3, Box 269, Lincoln, NH 03251. h. FERC Contact: Tom Papsidero,...

  20. Three-Component Glycolate Michael Reactions of Enolates, Silyl Glyoxylates, and α,β-Enones

    PubMed Central

    Schmitt, Daniel C.; Malow, Ericka J.; Johnson, Jeffrey S.

    2012-01-01

    Silyl glyoxylates react with enolates and enones to afford either glycolate aldol or Michael adducts. Product identity is controlled by the countercation associated with the enolate. Reformatsky nucleophiles in the presence of additional Zn(OTf)2 result in aldol coupling (A), while lithium enolates provide the Michael coupling (B). Deprotonation of the aldol product A with LDA induces equilibration to form the minor diastereomer of Michael product B. This observation suggests that formation of the major diastereomer of Michael product B does not occur via an aldol/retro-aldol/Michael sequence. PMID:22394389

  1. Tribute to Professor Anthony J. McMichael.

    PubMed

    Swaminathan, Ashwin; Lucas, Robyn M; Harley, David

    2014-01-01

    Emeritus Professor A. J. "Tony" McMichael (1942-2014) was an internationally renowned and pioneering Australian academic and advocate in epidemiology, who was passionate about understanding the influences of the environment on human health. In an illustrious career spanning more than four decades, he made significant contributions to the scientific community and policy discourse-including ground-breaking research related to the health of children. McMichael was a prolific academic writer with over 300 peer-reviewed papers; 160 book chapters and two sole-authored books. However, his outstanding talent was for integrating complex and seemingly unrelated strands from the environmental and health sciences into a cohesive narrative-and highlighting its relevance to lay persons, scientists and governments alike. He was instrumental in validating this nascent field of research and inspiring many others to follow his lead. PMID:27417490

  2. Tribute to Professor Anthony J. McMichael

    PubMed Central

    Swaminathan, Ashwin; Lucas, Robyn M.; Harley, David

    2014-01-01

    Emeritus Professor A. J. “Tony” McMichael (1942–2014) was an internationally renowned and pioneering Australian academic and advocate in epidemiology, who was passionate about understanding the influences of the environment on human health. In an illustrious career spanning more than four decades, he made significant contributions to the scientific community and policy discourse—including ground-breaking research related to the health of children. McMichael was a prolific academic writer with over 300 peer-reviewed papers; 160 book chapters and two sole-authored books. However, his outstanding talent was for integrating complex and seemingly unrelated strands from the environmental and health sciences into a cohesive narrative—and highlighting its relevance to lay persons, scientists and governments alike. He was instrumental in validating this nascent field of research and inspiring many others to follow his lead.

  3. Topological deformation of isolated horizons

    SciTech Connect

    Liko, Tomas

    2008-03-15

    We show that the Gauss-Bonnet term can have physical effects in four dimensions. Specifically, the entropy of a black hole acquires a correction term that is proportional to the Euler characteristic of the cross sections of the horizon. While this term is constant for a single black hole, it will be a nontrivial function for a system with dynamical topologies such as black-hole mergers: it is shown that for certain values of the Gauss-Bonnet parameter, the second law of black-hole mechanics can be violated.

  4. Space Weather and Satellite Engineering: An Interview With Michael Bodeau

    NASA Astrophysics Data System (ADS)

    Tretkoff, Ernie

    2010-03-01

    Michael Bodeau is a technical fellow at Northrop Grumman. Over his career, which has included positions at TRW, Hughes, and Boeing, he has designed telecommunications and scientific satellites for government and commercial operators and has studied the effects of space weather on satellites. In this interview, Bodeau describes how satellite engineers create "building codes" to help them design satellites that can withstand space weather events.

  5. Deciphering the roles of multiple additives in organocatalyzed Michael additions.

    PubMed

    Günler, Z Inci; Companyó, Xavier; Alfonso, Ignacio; Burés, Jordi; Jimeno, Ciril; Pericàs, Miquel A

    2016-05-21

    The synergistic effects of multiple additives (water and acetic acid) on the asymmetric Michael addition of acetone to nitrostyrene catalyzed by primary amine-thioureas (PAT) were precisely determined. Acetic acid facilitates hydrolysis of the imine intermediates, thus leading to catalytic behavior, and minimizes the formation of the double addition side product. In contrast, water slows down the reaction but minimizes catalyst deactivation, eventually leading to higher final yields. PMID:27128165

  6. Twofold polyketide branching by a stereoselective enzymatic Michael addition.

    PubMed

    Heine, Daniel; Sundaram, Srividhya; Bretschneider, Tom; Hertweck, Christian

    2015-06-18

    The versatility of the branching module of the rhizoxin polyketide synthase was tested in an in vitro enzyme assay with a polyketide mimic and branched (di)methylmalonyl-CoA extender units. Comparison of the products with synthetic reference compounds revealed that the module is able to stereoselectively introduce two branches in one step by a Michael addition-lactonisation sequence, thus expanding the scope of previously studied PKS systems. PMID:25994388

  7. Michael Davis: 2006 award for distinguished scientific contributions.

    PubMed

    2006-11-01

    Presents the citation for Michael Davis, who received the Award for Distinguished Scientific Contributions "for his major discoveries about the brain circuits underlying basic aspects of behavioral plasticity and learning." A brief profile and a selected bibliography, as well as Davis' award address, entitled Neural Systems Involved in Fear and Anxiety Measured With Fear-Potentiated Startle, accompany the citation. ((c) 2006 APA, all rights reserved). PMID:17115805

  8. Variable horizon in a peridynamic medium

    SciTech Connect

    Silling, Stewart A.; Littlewood, David J.; Seleson, Pablo

    2015-12-10

    Here, a notion of material homogeneity is proposed for peridynamic bodies with variable horizon but constant bulk properties. A relation is derived that scales the force state according to the position-dependent horizon while keeping the bulk properties unchanged. Using this scaling relation, if the horizon depends on position, artifacts called ghost forces may arise in a body under a homogeneous deformation. These artifacts depend on the second derivative of the horizon and can be reduced by employing a modified equilibrium equation using a new quantity called the partial stress. Bodies with piecewise constant horizon can be modeled without ghost forces by using a simpler technique called a splice. As a limiting case of zero horizon, both the partial stress and splice techniques can be used to achieve local-nonlocal coupling. Computational examples, including dynamic fracture in a one-dimensional model with local-nonlocal coupling, illustrate the methods.

  9. Variable horizon in a peridynamic medium.

    SciTech Connect

    Silling, Stewart Andrew; Littlewood, David John; Seleson, Pablo

    2014-10-01

    A notion of material homogeneity is proposed for peridynamic bodies with vari- able horizon but constant bulk properties. A relation is derived that scales the force state according to the position-dependent horizon while keeping the bulk properties un- changed. Using this scaling relation, if the horizon depends on position, artifacts called ghost forces may arise in a body under homogeneous deformation. These artifacts de- pend on the second derivative of horizon and can be reduced by use of a modified equilibrium equation using a new quantity called the partial stress . Bodies with piece- wise constant horizon can be modeled without ghost forces by using a technique called a splice between the regions. As a limiting case of zero horizon, both partial stress and splice techniques can be used to achieve local-nonlocal coupling. Computational examples, including dynamic fracture in a one-dimensional model with local-nonlocal coupling, illustrate the methods.

  10. Variable horizon in a peridynamic medium

    DOE PAGESBeta

    Silling, Stewart A.; Littlewood, David J.; Seleson, Pablo

    2015-12-10

    Here, a notion of material homogeneity is proposed for peridynamic bodies with variable horizon but constant bulk properties. A relation is derived that scales the force state according to the position-dependent horizon while keeping the bulk properties unchanged. Using this scaling relation, if the horizon depends on position, artifacts called ghost forces may arise in a body under a homogeneous deformation. These artifacts depend on the second derivative of the horizon and can be reduced by employing a modified equilibrium equation using a new quantity called the partial stress. Bodies with piecewise constant horizon can be modeled without ghost forcesmore » by using a simpler technique called a splice. As a limiting case of zero horizon, both the partial stress and splice techniques can be used to achieve local-nonlocal coupling. Computational examples, including dynamic fracture in a one-dimensional model with local-nonlocal coupling, illustrate the methods.« less

  11. Smooth horizons and quantum ripples

    NASA Astrophysics Data System (ADS)

    Golovnev, Alexey

    2015-05-01

    Black holes are unique objects which allow for meaningful theoretical studies of strong gravity and even quantum gravity effects. An infalling and a distant observer would have very different views on the structure of the world. However, a careful analysis has shown that it entails no genuine contradictions for physics, and the paradigm of observer complementarity has been coined. Recently this picture was put into doubt. In particular, it was argued that in old black holes a firewall must form in order to protect the basic principles of quantum mechanics. This AMPS paradox has already been discussed in a vast number of papers with different attitudes and conclusions. Here we want to argue that a possible source of confusion is the neglect of quantum gravity effects. Contrary to widespread perception, it does not necessarily mean that effective field theory is inapplicable in rather smooth neighbourhoods of large black hole horizons. The real offender might be an attempt to consistently use it over the huge distances from the near-horizon zone of old black holes to the early radiation. We give simple estimates to support this viewpoint and show how the Page time and (somewhat more speculative) scrambling time do appear.

  12. Theory underlying the peripheral vision horizon device

    NASA Technical Reports Server (NTRS)

    Money, K. E.

    1984-01-01

    Peripheral Vision Horizon Device (PVHD) theory states that the likelihood of pilot disorientation in flight is reduced by providing an artificial horizon that provides orientation information to peripheral vision. In considering the validity of the theory, three areas are explored: the use of an artificial horizon device over some other flight instrument; the use of peripheral vision over foveal vision; and the evidence that peripheral vision is well suited to the processing of orientation information.

  13. Spectroscopy of a weakly isolated horizon

    NASA Astrophysics Data System (ADS)

    Chen, Ge-Rui; Huang, Yong-Chang

    2016-06-01

    The spectroscopy of a weakly isolated horizon has been investigated. We obtain an equally spaced entropy spectrum with its quantum equal to the one given by Bekenstein (Phys Rev D 7:2333, 1973). We demonstrate that the quantization of entropy and area is a generic property of horizons which exists in a wide class of spacetimes admitting weakly isolated horizons. Our method based on the tunneling method also indicates that the entropy quantum of black hole horizons is closely related to Hawking temperature.

  14. The NMC Horizon Report: 2014 Library Edition

    ERIC Educational Resources Information Center

    Johnson, L.; Adams Becker, S.; Estrada, V.; Freeman, A.

    2014-01-01

    The internationally recognized "NMC Horizon Report" series and regional "NMC Technology Outlooks" are part of the NMC Horizon Project, a 12-year effort established in 2002 that annually identifies and describes emerging technologies likely to have a large impact over the coming five years in every sector of education around the…

  15. Reconceptualizing Knowledge at the Mathematical Horizon

    ERIC Educational Resources Information Center

    Zazkis, Rina; Mamolo, Ami

    2011-01-01

    This article extends the notion of "knowledge at the mathematical horizon" or "horizon knowledge" introduced by Ball and colleagues as a part of teachers' subject matter knowledge. Our focus is on teachers' mathematical knowledge beyond the school curriculum, that is, on mathematics learnt during undergraduate college or university studies. We…

  16. The Horizon Report: 2010 Museum Edition

    ERIC Educational Resources Information Center

    Johnson, L.; Witchey, H.; Smith, R.; Levine, A.; Haywood, K.

    2010-01-01

    The internationally recognized series of "Horizon Reports" is part of the New Media Consortium's Horizon Project, a comprehensive research venture established in 2002 that identifies and describes emerging technologies likely to have a large impact over the coming five years on a variety of sectors around the globe. This volume, the "2010 Horizon…

  17. Expanding your horizons in science and mathematics

    NASA Technical Reports Server (NTRS)

    Palmer, Cynthia E. A.

    1995-01-01

    The purpose of the 'Expanding Your Horizons in Science and Mathematics' program is to interest young women in grades six through twelve in a variety of careers where mathematics and science are important. Progress in encouraging young women to take courses in mathematics, science, and technological subjects is discussed. Also included are adult, student, and organizational information packets used for 'Expanding Your Horizons' conferences.

  18. Horizon Report: 2009 Economic Development Edition

    ERIC Educational Resources Information Center

    Johnson, L.; Levine, A.; Scott, C.; Smith, R.; Stone, S.

    2009-01-01

    The New Media Consortium's Horizon Project is an ongoing research project that seeks to identify and describe emerging technologies likely to have a large impact in education and other industries around the world over a five-year time period. The chief products of the project are the "Horizon Reports", an annual series of publications that…

  19. Horizon Report: 2010 K-12 Edition

    ERIC Educational Resources Information Center

    Johnson, L.; Smith, R.; Levine, A.; Haywood, K.

    2010-01-01

    The "Horizon Report" series is the most visible outcome of the New Media Consortium's Horizon Project, an ongoing research effort established in 2002 that identifies and describes emerging technologies likely to have a large impact on teaching, learning, research, or creative expression within education around the globe. This volume, the "2010…

  20. The NMC Horizon Report: 2015 Museum Edition

    ERIC Educational Resources Information Center

    Johnson, L.; Adams Becker, S.; Estrada, V.; Freeman, A.

    2015-01-01

    The internationally recognized series of "Horizon Reports" is part of the New Media Consortium's Horizon Project, a comprehensive research venture established in 2002 that identifies and describes emerging technologies likely to have a large impact over the coming years on a variety of sectors around the globe. This "2015 Horizon…

  1. Chemopreventive Agents from Physalis minima Function as Michael Reaction Acceptors

    PubMed Central

    Men, Ruizhi; Li, Ning; Ding, Chihong; Tang, Yingzhan; Xing, Yachao; Ding, Wanjing; Ma, Zhongjun

    2016-01-01

    Background: The fruits of some varieties of genus Physalis have been used as delicious fruits and functional food in the Northeast of China. Materials and Methods: To reveal the functional material basis, we performed bioactivity-guided phytochemical research and chemopreventive effect assay of the constituents from Physalis minima. Results: It was demonstrated that the ethyl acetate extract of P. minima L. (EEPM) had potential quinone reductase (QR) inducing activity with induction ratio (IR, QR induction activity) value of 1.47 ± 0.24, and glutathione binding property as potential Michael reaction acceptors (with an α, β-unsaturated ketone moiety). Furthermore, bioactivity-guided phytochemical research led eight compounds (1–8), which were elucidated as 3-isopropyl-5-acetoxycyclohexene-2-one-1 (1), isophysalin B (2), physalin G (3), physalin D (4), physalin I (5), physordinose B (6), stigmasterol-3-O-β-D-glucopyranoside (7) and 5α-6β-dihydroxyphysalin R (8) on the basis of nuclear magnetic resonance spectroscopy analyses and HRESIMS. Then, isophysalin B (2) and physordinose B (6) showed significant QR inducing activity with IR value of 2.80 ± 0.19 and 2.38 ± 0.46, respectively. SUMMARY An ultra-performance liquid chromatographic method with glutathione as the substrate was used to detect the Michael reaction acceptors in extracts of Physalis minima (EPM)We investigated the chemical constituents of EPM guided by biological activity methodIsophysalin B (1) and physordinose B (6) showed strong quinone reductase inducing activity with induction ratio values of 2.80 ± 0.19 and 2.38 ± 0.46This study generated useful information for consumers and many encourage researchers to utilize edible fruits from Physalis as a source of phytochemicals Abbreviations used: EPM: Extracts of Physalis minima, EEPM: Ethyl acetate extract of Physalis minima L., GSH: Glutathione, MRAs: Michael reaction acceptors, QR: Quinone reductase. PMID:27279713

  2. STS-81 Commander Michael Baker at SLF for TCDT

    NASA Technical Reports Server (NTRS)

    1996-01-01

    STS-81 Mission Commander Michael A. Baker arrives at KSC's Shuttle Landing Facility in his NASA T-38 jet. He and five other crew members will participate in the Terminal Countdown Demonstration Test (TCDT), a dress rehearsal for the planned Jan. 12 launch. STS-81 will be the fifth Shuttle-Mir docking. During the flight, Mission Specialist J.M. 'Jerry' Linenger will transfer to the Russian Mir Space Station for an extended stay, replacing astronaut John E. Blaha, who will return to Earth on the Space Shuttle orbiter Atlantis at the conclusion of the scheduled nine-day STS-81 mission.

  3. Substrate-controlled Michael additions of chiral ketones to enones.

    PubMed

    Fàbregas, Mireia; Gómez-Palomino, Alejandro; Pellicena, Miquel; Reina, Daniel F; Romea, Pedro; Urpí, Fèlix; Font-Bardia, Mercè

    2014-12-01

    Substrate-controlled Michael additions of the titanium(IV) enolate of lactate-derived ketone 1 to acyclic α,β-unsaturated ketones in the presence of a Lewis acid (TiCl4 or SnCl4) provide the corresponding 2,4-anti-4,5-anti dicarbonyl compounds in good yields and excellent diastereomeric ratios. Likely, the nucleophilic species involved in such additions are bimetallic enolates that may add to enones through cyclic transition states. Finally, further studies indicate that a structurally related β-benzyloxy chiral ketone can also participate in such stereocontrolled conjugate additions. PMID:25423031

  4. Nearly Finished Genomes Produced Using Gel Microdroplet Culturing (Seventh Annual Sequencing, Finishing, Analysis in the Future (SFAF) Meeting 2012)

    ScienceCinema

    Fitzsimmons, Michael [LANL

    2013-01-25

    Michael Fitzsimmons from Los Alamos National Laboratory gives a talk titled "Nearly Finished Genomes Produced Using Gel Microdroplet Culturing" at the 7th Annual Sequencing, Finishing, Analysis in the Future (SFAF) Meeting held in June, 2012 in Santa Fe, NM.

  5. Chandra Uncovers New Evidence For Event Horizons Surrounding Black Holes

    NASA Astrophysics Data System (ADS)

    2001-01-01

    SAN DIEGO -- Astronomers have used NASA's Chandra X-ray Observatory to study some of the darkest black holes yet observed. Their work strongly confirms the reality of the "event horizon," the one-way membrane around black holes predicted by Einstein's theory of relativity. The findings were presented today at the American Astronomical Society meeting by Drs. Michael Garcia, Jeffrey McClintock, Ramesh Narayan, and Stephen Murray of the Harvard-Smithsonian Center for Astrophysics and Dr. Paul Callanan of University College, Cork, Ireland. With results that fundamentally differ from earlier black hole studies, Garcia and his colleagues have shown that some recently discovered black holes are not only ultra-dense, but actually possess event horizons that "vacuum up" energy from their surroundings. "It is a bit odd to say we've discovered something by seeing almost nothing at all -- less than the smile of the Cheshire cat, so to speak," said Garcia, lead author on a paper submitted to the Astrophysical Journal, "but, in essence, this is what we have done." Using data from Chandra and previous X-ray satellites like ROSAT, the Chandra team studied a dozen "X-ray novas," so named because they occasionally erupt as brilliant X-ray sources then settle into decades of dormancy. The great outpouring of X rays is due to a stream of gas that is pulled from the surface of a Sun-like companion star onto a compact object, either a black hole or a neutron star. By comparing the energy output from the dormant X-ray novas, the team discovered that the sources with black holes emitted only one percent as much energy while dormant as did the X-ray novae with neutron stars. "The most straightforward explanation of these observations is that the black hole candidates we have studied have event horizons that swallow just about all of the energy that surrounds them," said Murray. "Indeed, one could even say that this work shows why black holes deserve to be called ‘black.’" "The event

  6. Quasilocal approach to general universal horizons

    NASA Astrophysics Data System (ADS)

    Maciel, Alan

    2016-05-01

    Theories of gravity with a preferred foliation usually display arbitrarily fast signal propagation, changing the black hole definition. A new inescapable barrier, the universal horizon, has been defined and many static and spherically symmetric examples have been studied in the literature. Here, we translate the usual definition of the universal horizon in terms of an optical scalar built with the preferred flow defined by the preferred spacetime foliation. The new expression has the advantages of being of quasilocal nature and independent of specific spacetime symmetries in order to be well defined. Therefore, we propose it as a definition for general quasilocal universal horizons. Using the new formalism, we show that there is no universal analog of cosmological horizons for Friedmann-Lemaître-Robertson-Walker models for any scale factor function, and we also state that quasilocal universal horizons are restricted to trapped regions of the spacetime. Using the evolution equation, we analyze the formation of universal horizons under a truncated Hořava-Lifshitz theory, in spherical symmetry, showing the existence of regions in parameter space where the universal horizon formation cannot be smooth from the center, under some physically reasonable assumptions. We conclude with our view on the next steps for the understanding of black holes in nonrelativistic gravity theories.

  7. Production and decay of evolving horizons

    NASA Astrophysics Data System (ADS)

    Nielsen, Alex B.; Visser, Matt

    2006-07-01

    We consider a simple physical model for an evolving horizon that is strongly interacting with its environment, exchanging arbitrarily large quantities of matter with its environment in the form of both infalling material and outgoing Hawking radiation. We permit fluxes of both lightlike and timelike particles to cross the horizon, and ask how the horizon grows and shrinks in response to such flows. We place a premium on providing a clear and straightforward exposition with simple formulae. To be able to handle such a highly dynamical situation in a simple manner we make one significant physical restriction—that of spherical symmetry—and two technical mathematical restrictions: (1) we choose to slice the spacetime in such a way that the spacetime foliations (and hence the horizons) are always spherically symmetric. (2) Furthermore, we adopt Painlevé Gullstrand coordinates (which are well suited to the problem because they are nonsingular at the horizon) in order to simplify the relevant calculations. Of course physics results are ultimately independent of the choice of coordinates, but this particular coordinate system yields a clean physical interpretation of the relevant physics. We find particularly simple forms for surface gravity, and for the first and second law of black hole thermodynamics, in this general evolving horizon situation. Furthermore, we relate our results to Hawking's apparent horizon, Ashtekar and co-worker's isolated and dynamical horizons, and Hayward's trapping horizon. The evolving black hole model discussed here will be of interest, both from an astrophysical viewpoint in terms of discussing growing black holes and from a purely theoretical viewpoint in discussing black hole evaporation via Hawking radiation.

  8. NEW HORIZONS IN SENSOR DEVELOPMENT

    PubMed Central

    Intille, Stephen S.; Lester, Jonathan; Sallis, James F.; Duncan, Glen

    2011-01-01

    Background Accelerometery and other sensing technologies are important tools for physical activity measurement. Engineering advances have allowed developers to transform clunky, uncomfortable, and conspicuous monitors into relatively small, ergonomic, and convenient research tools. New devices can be used to collect data on overall physical activity and in some cases posture, physiological state, and location, for many days or weeks from subjects during their everyday lives. In this review article, we identify emerging trends in several types of monitoring technologies and gaps in the current state of knowledge. Best practices The only certainty about the future of activity sensing technologies is that researchers must anticipate and plan for change. We propose a set of best practices that may accelerate adoption of new devices and increase the likelihood that data being collected and used today will be compatible with new datasets and methods likely to appear on the horizon. Future directions We describe several technology-driven trends, ranging from continued miniaturization of devices that provide gross summary information about activity levels and energy expenditure, to new devices that provide highly detailed information about the specific type, amount, and location of physical activity. Some devices will take advantage of consumer technologies, such as mobile phones, to detect and respond to physical activity in real time, creating new opportunities in measurement, remote compliance monitoring, data-driven discovery, and intervention. PMID:22157771

  9. [Visual illusions and moving horizon].

    PubMed

    Zhdan'ko, I M; Chulaevskiĭ, A O; Kovalenko, P A

    2012-09-01

    Results of psychological "additional investigation" of the crash of Boeing-737, "Aeroflot-Nord" on 14.09.2008 near Perm are presented. 37 pilots from the one of the leading airline companies sensed the attitude and rolling out the aircraft to the forward flight under the moving horizon with straight display of bank and tangage (view from the aircraft to the ground) in model conditions. 29 pilots (78.4%) made a mistake at determining the roll direction and tangage, they made a mistake at determining the roll direction 61 times (16.4%) and 44 times at determining the tangage direction, in other words they confused left and right bank and also nose-up and nose-down. Visual illusions of mobility of space and handling of ground (instead of aircraft) during the flight were revealed in pilots. These illusions may be the important cause of the following crashes. The necessity of "back" faultless display of bank in all aircrafts of civil aviation and development of computer complex for training of visual spatial orientation is proved. PMID:23156114

  10. Dr. Marco Marra: Pioneer and Visionary in Cancer Genomics Research | Office of Cancer Genomics

    Cancer.gov

    Dr. Marco Marra is a highly distinguished genomics and bioinformatics researcher. He is the Director of Canada’s Michael Smith Genome Sciences Centre at the BC Cancer Agency and holds a faculty position at the University of British Columbia. The Centre is a state-of-the-art sequencing facility in Vancouver, Canada, with a major focus on the study of cancers.  Many of their research projects are undertaken in collaborations with other Canadian and international institutions.

  11. Black holes with bottle-shaped horizons

    NASA Astrophysics Data System (ADS)

    Chen, Yu; Teo, Edward

    2016-06-01

    We present a new class of four-dimensional AdS black holes with noncompact event horizons of finite area. The event horizons are topologically spheres with one puncture, with the puncture pushed to infinity in the form of a cusp. Because of the shape of their event horizons, we call such black holes "black bottles." The solution was obtained as a special case of the Plebański-Demiański solution, and may describe either static or rotating black bottles. For certain ranges of parameters, an acceleration horizon may also appear in the space-time. We study the full parameter space of the solution, and the various limiting cases that arise. In particular, we show how the rotating black hole recently discovered by Klemm arises as a special limit.

  12. Horizon Entropy from Quantum Gravity Condensates

    NASA Astrophysics Data System (ADS)

    Oriti, Daniele; Pranzetti, Daniele; Sindoni, Lorenzo

    2016-05-01

    We construct condensate states encoding the continuum spherically symmetric quantum geometry of a horizon in full quantum gravity, i.e., without any classical symmetry reduction, in the group field theory formalism. Tracing over the bulk degrees of freedom, we show how the resulting reduced density matrix manifestly exhibits a holographic behavior. We derive a complete orthonormal basis of eigenstates for the reduced density matrix of the horizon and use it to compute the horizon entanglement entropy. By imposing consistency with the horizon boundary conditions and semiclassical thermodynamical properties, we recover the Bekenstein-Hawking entropy formula for any value of the Immirzi parameter. Our analysis supports the equivalence between the von Neumann (entanglement) entropy interpretation and the Boltzmann (statistical) one.

  13. Horizon Entropy from Quantum Gravity Condensates.

    PubMed

    Oriti, Daniele; Pranzetti, Daniele; Sindoni, Lorenzo

    2016-05-27

    We construct condensate states encoding the continuum spherically symmetric quantum geometry of a horizon in full quantum gravity, i.e., without any classical symmetry reduction, in the group field theory formalism. Tracing over the bulk degrees of freedom, we show how the resulting reduced density matrix manifestly exhibits a holographic behavior. We derive a complete orthonormal basis of eigenstates for the reduced density matrix of the horizon and use it to compute the horizon entanglement entropy. By imposing consistency with the horizon boundary conditions and semiclassical thermodynamical properties, we recover the Bekenstein-Hawking entropy formula for any value of the Immirzi parameter. Our analysis supports the equivalence between the von Neumann (entanglement) entropy interpretation and the Boltzmann (statistical) one. PMID:27284642

  14. Information Horizons in Complex Networks

    NASA Astrophysics Data System (ADS)

    Sneppen, Kim

    2005-03-01

    We investigate how the structure constrain specific communication in social-, man-made and biological networks. We find that human networks of governance and collaboration are predictable on teat-a-teat level, reflecting well defined pathways, but globally inefficient (1). In contrast, the Internet tends to have better overall communication abilities, more alternative pathways, and is therefore more robust. Between these extremes are the molecular network of living organisms. Further, for most real world networks we find that communication ability is favored by topology on small distances, but disfavored at larger distances (2,3,4). We discuss the topological implications in terms of modularity and the positioning of hubs in the networks (5,6). Finally we introduce some simple models which demonstarte how communication may shape the structure of in particular man made networks (7,8). 1) K. Sneppen, A. Trusina, M. Rosvall (2004). Hide and seek on complex networks [cond-mat/0407055] 2) M. Rosvall, A. Trusina, P. Minnhagen and K. Sneppen (2004). Networks and Cities: An Information Perspective [cond-mat/0407054]. In PRL. 3) A. Trusina, M. Rosvall, K. Sneppen (2004). Information Horizons in Networks. [cond-mat/0412064] 4) M. Rosvall, P. Minnhagen, K. Sneppen (2004). Navigating Networks with Limited Information. [cond-mat/0412051] 5) S. Maslov and K. Sneppen (2002). Specificity and stability in topology of protein networks Science 296, 910-913 [cond-mat/0205380]. 6) A. Trusina, S. Maslov, P. Minnhagen, K. Sneppen Hierarchy Measures in Complex Networks. Phys. Rev. Lett. 92, 178702 [cond-mat/0308339]. 7) M. Rosvall and K. Sneppen (2003). Modeling Dynamics of Information Networks. Phys. Rev. Lett. 91, 178701 [cond-mat/0308399]. 8) B-J. Kim, A. Trusina, P. Minnhagen, K. Sneppen (2003). Self Organized Scale-Free Networks from Merging and Regeneration. nlin.AO/0403006. In European Journal of Physics.

  15. Schizophrenia: Hope on the Horizon.

    PubMed

    Sullivan, Patrick F

    2015-01-01

    In July 2014, an international consortium of schizophrenia researchers co-founded by the author mounted the largest biological experiment in the history of psychiatry and found eighty new regions in the genome associated with the illness. With many more avenues for exploring the biological underpinnings of schizophrenia now available to neuroscientists, hope may be on the way for the estimated 2.4 million Americans and 1 in 100 people worldwide affected by the illness, one in which drugs have limited impact and there is no known cure. PMID:27358664

  16. Astronaut C. Michael Foale prepares to return to JSC

    NASA Technical Reports Server (NTRS)

    1997-01-01

    At the Skid Strip on Cape Canaveral Air Station, astronaut C. Michael Foale and his children (5-year-old Jenna, left, and 3- year-old Ian, in Foale's arms) prepare to return to the Johnson Space Center in Houston, TX. The Oct. 6 landing of the Space Shuttle orbiter Atlantis following the successful STS-86 mission returned Foale to Earth after an approximate four-and-a-half- month stay aboard the Russian Space Station Mir. Foale, a member of the Mir 24 crew, was dropped off on the Russian space station during the STS-84 mission in mid-May. He joined the STS-86 crew aboard Atlantis for the return trip to Earth. STS-86 was the seventh docking of the Space Shuttle with the Mir. STS-86 Mission Specialist David A. Wolf replaced Foale on the Russian station.

  17. Verification of the structural alerts for Michael acceptors.

    PubMed

    Schultz, T Wayne; Yarbrough, Jason W; Hunter, Robert S; Aptula, Aynur O

    2007-09-01

    A diverse series of polarized alpha,beta-unsaturated and related compounds were evaluated for reactivity with a spectrophotometric assay using the sulfhydryl group in the form of the cysteine residue of the tripeptide GSH as a model nucleophile. The reactive end point (RC 50) calculations were compared to previously described structural alerts based on conventional organic chemistry. This comparison focused on polarized alpha,beta-unsaturates, including ones containing an aldehyde, ketone, ester, sulfoxide, sulfone, sulfonate, nitro, or cyano moiety as well as ortho- and para-pyridino compounds and ortho- and para-quinones. The alerts were coded by substructure and are available in open-source software ( http://sourceforge.net/projects/chemeval). Comparisons of reactivity between selected analogues revealed that only the polarized alpha,beta-unsaturates were reactive. These results verified the coded structural alerts that define the applicability domain for Michael acceptor electrophiles. PMID:17672510

  18. STS-94 Mission Specialist Michael Gernhardt suits up

    NASA Technical Reports Server (NTRS)

    1997-01-01

    STS-94 Mission Specialist Michael L. Gernhardt is assisted into his launch/entry suit by a suit technician in the Operations and Checkout (O&C) Building. He first flew in this capacity on STS- 69. He has been a professional deep sea diver and engineer and holds a doctorate in bioengineering. Gernhardt will be in charge of the Blue shift and as flight engineer will operate and maintain the orbiter while Halsell and Still are asleep as members of the Red shift. He will also back them up on the flight deck during the ascent and re-entry phases of the mission. Gernhardt and six fellow crew members will shortly depart the O&C and head for Launch Pad 39A, where the Space Shuttle Columbia will lift off during a launch window that opens at 1:50 a.m. EDT, July opportunity to lift off before Florida summer rain showers reached the space center.

  19. STS-83 Mission Specialist Michael L. Gernhardt suits up

    NASA Technical Reports Server (NTRS)

    1997-01-01

    STS-83 Mission Specialist Michael L. Gernhardt is assisted into his launch/entry suit in the Operations and Checkout (O&C) Building. He first flew in this capacity on STS-69. He has been a professional deep sea diver and engineer and holds a doctorate in bioengineering. Gernhardt will be in charge of the Blue shift and as flight engineer will operate and maintain the orbiter while Halsell and Still are asleep as members of the Red shift. He will also back them up on the flight deck during the ascent and re- entry phases of the mission. Gernhardt and six fellow crew members will shortly depart the O&C and head for Launch Pad 39A, where the Space Shuttle Columbia will lift off during a launch window that opens at 2:00 p.m. EST, April 4.

  20. Michael E. Lamb: Award for Distinguished Scientific Applications of Psychology.

    PubMed

    2015-11-01

    The APA Award for Distinguished Scientific Applications of Psychology is presented to a person who, in the opinion of the Committee on Scientific Awards, has made distinguished theoretical or empirical advances leading to the understanding or amelioration of important practical problems. The 2015 recipient is Michael E. Lamb, who "has significantly advanced understanding of the developmental and contextual factors affecting the delivery and impact of child care in the early years of life; the role of parent-child relationships in development; and the cognitive, emotional, and social factors affecting the quality of children's testimony, especially in cases of sexual and physical abuse." award citation, biography, and a selected bibliography are presented here. PMID:26618945

  1. 77 FR 61596 - Wheatley, Michael I.; Garrison, Drummond E.; Notice of Filing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-10

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Wheatley, Michael I.; Garrison, Drummond E.; Notice of Filing Take notice that on September 28, 2012, Michael I. Wheatley and Drummond E. Garrison submitted for filing, an application for authority to hold...

  2. 75 FR 22436 - Michael Williams-Control Exemption-St. Maries River Railroad, Inc.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-28

    ... Surface Transportation Board Michael Williams-Control Exemption-St. Maries River Railroad, Inc. Michael Williams (applicant),\\1\\ a noncarrier, has filed a verified notice of exemption to acquire control of St.... Petitions for stay must be filed no later than May 5, 2010 (at least 7 days before the exemption...

  3. A Response to Michael Newman's "Calling Transformative Learning into Question: Some Mutinous Thoughts"

    ERIC Educational Resources Information Center

    Cranton, Patricia; Kasl, Elizabeth

    2012-01-01

    This article presents the authors' response to Michael Newman's "Calling Transformative Learning into Question: Some Mutinous Thoughts". The authors begin by noting their appreciation of Michael Newman's challenge to transformative learning theory. In their response, the authors review and comment on the fatal flaws presented by Newman and then…

  4. Star-Paths, Stones and Horizon Astronomy

    NASA Astrophysics Data System (ADS)

    Brady, Bernadette

    2015-05-01

    Archaeoastronomers tend to approach ancient monuments focusing on the landscape and the horizon calendar events of sun and moon and, due to problems with precession, generally ignore the movement of the stars. However, locating the position of solar calendar points on the horizon can have other uses apart from calendar and/or cosmological purposes. This paper firstly suggests that the stars do not need to be ignored. By considering the evidence of the Phaenomena, a sky poem by Aratus of Soli, a third century BC Greek poet, and his use of second millennium BC star lore fragments, this paper argues that the stars were a part of the knowledge of horizon astronomy. Aratus' poem implied that the horizon astronomy of the late Neolithic and Bronze Age periods included knowledge of star-paths or 'linear constellations' that were defined by particular horizon calendar events and other azimuths. Knowledge of such star-paths would have enabled navigation and orientation, and by using permanent markers, constructed or natural, to define these paths, they were immune to precession as the stones could redefine a star-path for a future generation. Finally the paper presents other possible intentions behind the diverse orientation of passage tombs and some megalithic sites.

  5. On the Bartnik mass of apparent horizons

    NASA Astrophysics Data System (ADS)

    Mantoulidis, Christos; Schoen, Richard

    2015-10-01

    In this paper we characterize the intrinsic geometry of apparent horizons (outermost marginally outer trapped surfaces) in asymptotically flat spacetimes; that is, the Riemannian metrics on the two sphere which can arise. Furthermore we determine the minimal ADM mass of a spacetime containing such an apparent horizon. The results are conveniently formulated in terms of the quasi-local mass introduced by Bartnik (1989 Phys. Rev. Lett. 62 2346-8). The Hawking mass provides a lower bound for Bartnik’s quasilocal mass on apparent horizons by way of Penrose’s conjecture on time symmetric slices, proven in 1997 by Huisken and Ilmanen (2001 J. Differ. Geom. 59 353-437) and in full generality in 1999 by Bray (2001 J. Differ. Geom. 59 177-267). We compute Bartnik’s mass for all non-degenerate apparent horizons and show that it coincides with the Hawking mass. As a corollary we disprove a conjecture due to Gibbons in the spirit of Thorne’s hoop conjecture (Gibbons 2009 arXiv:0903.1580), and construct a new large class of examples of apparent horizons with the integral of the negative part of the Gauss curvature arbitrarily large.

  6. 75 FR 62635 - Proposed Information Collection (Patient Satisfaction Survey Michael E. DeBakey Home Care Program...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-12

    ... AFFAIRS Proposed Information Collection (Patient Satisfaction Survey Michael E. DeBakey Home Care Program... needed to determine patients' satisfaction with services provided by or through the Michael E. DeBakey.... Title: Patient Satisfaction Survey Michael E. DeBakey Home Care Program, VA Form 10-0476. OMB...

  7. 77 FR 69550 - Proposed Information Collection (Patient Satisfaction Survey Michael E. DeBakey Home Care Program...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-19

    ... AFFAIRS Proposed Information Collection (Patient Satisfaction Survey Michael E. DeBakey Home Care Program... provided by or through the Michael E. DeBakey Home Care Program. DATES: Written comments and... information technology. Title: Patient Satisfaction Survey Michael E. DeBakey Home Care Program, VA Form...

  8. 77 FR 30047 - Notice of Opportunity for Public Comment on Surplus Property Release at Michael J Smith Field...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-21

    ... Michael J Smith Field, Beaufort, NC AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice... approximately 7.5 acres of airport property, located at the Michael J Smith Field, be used for aeronautical... Authority to release approximately 7.5 acres of airport property at the Michael J Smith Field. The...

  9. Regulation of human dihydrodiol dehydrogenase by Michael acceptor xenobiotics.

    PubMed

    Ciaccio, P J; Jaiswal, A K; Tew, K D

    1994-06-01

    A human oxidoreductase (H-37) that is overexpressed in ethacrynic acid-resistant HT29 colon cells (Ciaccio, P. J., Stuart, J.E., and Tew, K.D. (1993) Mol. Pharmacol. 43, 845-853) has been identified as a dihydrodiol dehydrogenase. Translated protein from a dihydrodiol dehydrogenase cDNA isolated from a library prepared from ethacrynic acid-resistant HT29 cell poly(A+) RNA was recognized by anti-H-37 IgG and was identical in molecular weight with H-37. The isolated cDNA was identical in both nucleotide and amino acid sequences with the recently cloned liver dihydrodiol dehydrogenase (Stolz, A., Hammond, L., Lou, H., Takikawa, H., Ronk, M., and Shively, J.E. (1993) J. Biol. Chem. 268, 10448-10457). Using this cDNA as probe, we have examined its induction by Michael acceptors. The steady state dihydrodiol dehydrogenase mRNA level in the ethacrynic acid-resistant line was increased 30-fold relative to that of wild-type cells. Twenty-four hour treatment of wild-type cells with ethacrynic acid or dimethyl maleate increased mRNA 10-fold and 5-fold, respectively. These changes are accompanied by both increased protein expression and increased NADP-dependent 1-acenaphthenol oxidative activity in cell cytosol. In gel shift assays, compared to wild type controls, increased binding of NAD(P)H quinone oxidoreductase human antioxidant response element (hARE) DNA to redox labile protein complexes present in treated and resistant cell nuclear extract was observed. Ethacrynic acid induced CAT activity 2-fold in Hepa1 cells stably transfected with NAD(P)H quinone oxidoreductase hARE-tk-CAT chimeric gene construct. Thus, dihydrodiol dehydrogenase protein is inducible by de novo synthesis from mRNA by structurally related monofunctional inducer Michael acceptors. Altered in vitro binding of nuclear protein to the hARE is indirect evidence for the involvement of an element similar to hARE in the regulation of dihydrodiol dehydrogenase by these agents. PMID:7515059

  10. Holography of 3D flat cosmological horizons.

    PubMed

    Bagchi, Arjun; Detournay, Stéphane; Fareghbal, Reza; Simón, Joan

    2013-04-01

    We provide a first derivation of the Bekenstein-Hawking entropy of 3D flat cosmological horizons in terms of the counting of states in a dual field theory. These horizons appear in the flat limit of nonextremal rotating Banados-Teitleboim-Zanelli black holes and are remnants of the inner horizons. They also satisfy the first law of thermodynamics. We study flat holography as a limit of AdS(3)/CFT(2) to semiclassically compute the density of states in the dual theory, which is given by a contraction of a 2D conformal field theory, exactly reproducing the bulk entropy in the limit of large charges. We comment on how the dual theory reproduces the bulk first law and how cosmological bulk excitations are matched with boundary quantum numbers. PMID:25166977

  11. East Rim of Endeavour Crater on Horizon

    NASA Technical Reports Server (NTRS)

    2009-01-01

    [figure removed for brevity, see original site]

    A high point on the distant eastern rim of Endeavour Crater is visible on the horizon in this image taken by the panoramic camera (Pancam) on NASA's Mars Exploration Rover Opportunity on March 8, 2009, during the 1,821st Martian day, or sol, of the rover's mission on Mars.

    That portion of Endeavour's rim is about 34 kilometers (21 miles) away from Opportunity's position west of the crater when the image was taken. The width of the image covers approximately one degree of the horizon.

  12. North Rim of Endeavour Crater on Horizon

    NASA Technical Reports Server (NTRS)

    2009-01-01

    [figure removed for brevity, see original site]

    A northern portion of the rim of Endeavour Crater is visible on the horizon of this image taken by the panoramic camera (Pancam) on NASA's Mars Exploration Rover Opportunity on March 7, 2009, during the 1,820st Martian day, or sol, of the rover's mission on Mars.

    That portion of Endeavour's rim is about 20 kilometers (12 miles) away from Opportunity's position west of the crater when the image was taken. The width of the image covers approximately one degree of the horizon.

  13. Expanding your horizons in science and mathematics

    NASA Technical Reports Server (NTRS)

    1985-01-01

    Through the presentation of its Expanding Your Horizons in Science and Mathematics career education conferences for secondary school young women, the Math/Science Network continues its efforts to remove the educational, psychological, and cultural barriers which prevent women from entering math-and science-based careers. The Expanding Your Horizons conferences were presented on 77 college, university and high school campuses across the United States. This year, these unique one day conferences reached 15,500 students, 3,000 parents and educators, and involved 3,000 career women who volunteered their services as conference planners, workshop leaders, speakers, and role models.

  14. Hair-brane ideas on the horizon

    NASA Astrophysics Data System (ADS)

    Martinec, Emil J.; Niehoff, Ben E.

    2015-11-01

    We continue an examination of the microstate geometries program begun in arXiv:1409.6017, focussing on the role of branes that wrap the cycles which degenerate when a throat in the geometry deepens and a horizon forms. An associated quiver quantum mechanical model of minimally wrapped branes exhibits a non-negligible fraction of the gravitational entropy, which scales correctly as a function of the charges. The results suggest a picture of AdS3/CFT2 duality wherein the long string that accounts for BTZ black hole entropy in the CFT description, can also be seen to inhabit the horizon of BPS black holes on the gravity side.

  15. Horizons and plane waves: A review

    SciTech Connect

    Hubeny, Veronika E.; Rangamani, Mukund

    2003-11-06

    We review the attempts to construct black hole/string solutions in asymptotically plane wave spacetimes. First, we demonstrate that geometries admitting a covariantly constant null Killing vector cannot admit event horizons, which implies that pp-waves can't describe black holes. However, relaxing the symmetry requirements allows us to generate solutions which do possess regular event horizons while retaining the requisite asymptotic properties. In particular, we present two solution generating techniques and use them to construct asymptotically plane wave black string/brane geometries.

  16. Evidence for a sedimentary siloxane horizon

    SciTech Connect

    Pellenbarg, R.E.; Tevault, D.E.

    1986-07-01

    Selected samples from two Puget Sound sediment cores have been analyzed for poly(organo)siloxanes(silicones). One core was 60 years old at 30-cm depth (ages by lead-210 dating) and showed no evidence for silicones there. The second, 15 years old at depth, exhibited silicones at depth. Clearly shown is evidence for a siloxane horizon in theses two cores, with the presence of the horizon directly related to the fact that silicones have been in widespread use only since World War II. All samples were analyzed by solvent extraction and diffuse reflectance Fourier transform infrared spectrometry. 10 references, 2 figures, 1 table.

  17. Aerosol physical properties from satellite horizon inversion

    NASA Technical Reports Server (NTRS)

    Gray, C. R.; Malchow, H. L.; Merritt, D. C.; Var, R. E.; Whitney, C. K.

    1973-01-01

    The feasibility is investigated of determining the physical properties of aerosols globally in the altitude region of 10 to 100 km from a satellite horizon scanning experiment. The investigation utilizes a horizon inversion technique previously developed and extended. Aerosol physical properties such as number density, size distribution, and the real and imaginary components of the index of refraction are demonstrated to be invertible in the aerosol size ranges (0.01-0.1 microns), (0.1-1.0 microns), (1.0-10 microns). Extensions of previously developed radiative transfer models and recursive inversion algorithms are displayed.

  18. Hair from the Isolated Horizon Perspective

    NASA Astrophysics Data System (ADS)

    Corichi, A.; Sudarsky, D.

    2002-12-01

    The recently introduced Isolated Horizons (IH) formalism has become a powerful tool for realistic black hole physics. In particular, it generalizes the zeroth and first laws of black hole mechanics in terms of quasi-local quantities and serves as a starting point for quantum entropy calculations. In this note we consider theories which admit hair, and analyze some new results that the IH provides, when considering solitons and stationary solutions. Furthermore, the IH formalism allows to state uniqueness conjectures (i.e. horizon 'no-hair conjectures') for the existence of solutions.

  19. Apollo 11 Astronaut Michael Collins Prepares for Weightless Conditions

    NASA Technical Reports Server (NTRS)

    1969-01-01

    In preparation of the nation's first lunar landing mission, Apollo 11 crew members underwent training to practice activities they would be performing during the mission. In this photograph, astronaut Collins (left) and chief astronaut and director of flight crew operations, Donald K. Slayton, walk away from a T-38 jet plane at Patrick Air Force Base. The two had been flying arcs to give Collins more time under weightless conditions. The Apollo 11 mission launched from the Kennedy Space Center (KSC) in Florida via the Marshall Space Flight Center (MSFC) developed Saturn V launch vehicle on July 16, 1969 and safely returned to Earth on July 24, 1969. Aboard the space craft were astronauts Neil A. Armstrong, commander; Michael Collins, Command Module (CM) pilot; and Edwin E. (Buzz) Aldrin Jr., Lunar Module (LM) pilot. The CM, 'Columbia', piloted by Collins, remained in a parking orbit around the Moon while the LM, 'Eagle'', carrying astronauts Armstrong and Aldrin, landed on the Moon. On July 20, 1969, Armstrong was the first human to ever stand on the lunar surface, followed by Aldrin. During 2½ hours of surface exploration, the crew collected 47 pounds of lunar surface material for analysis back on Earth. With the success of Apollo 11, the national objective to land men on the Moon and return them safely to Earth had been accomplished

  20. STS-103 M.S. Michael Foale during TCDT activities

    NASA Technical Reports Server (NTRS)

    1999-01-01

    STS-103 Mission Specialist C. Michael Foale (Ph.D.) is ready to take his turn at driving a small armored personnel carrier that is part of emergency egress training during Terminal Countdown Demonstration Test (TCDT) activities. The tracked vehicle could be used by the crew in the event of an emergency at the pad during which the crew must make a quick exit from the area. The TCDT also provides simulated countdown exercises and opportunities to inspect the mission payloads in the orbiter's payload bay. STS-103 is a 'call-up' mission due to the need to replace and repair portions of the Hubble Space Telescope. Although Hubble is operating normally and conducting its scientific observations, only three of its six gyroscopes are working properly. Four EVA's are planned to make the necessary repairs and replacements on the telescope. The other STS-103 crew members are Commander Curtis L. Brown Jr., Pilot Scott J. Kelly, and Mission Specialists Steven L. Smith , John M. Grunsfeld (Ph.D.), and Claude Nicollier of Switzerland and Jean-Frangois Clervoy of France, who are with the European Space Agency. The mission is targeted for launch Dec. 6 at 2:37 a.m. EST.

  1. [Michael Servetus' physiology in the light of his anthropology].

    PubMed

    Spielmann, J; Sebestyén, M

    1983-01-01

    This essay starts with a short description of the life and works of Michael Servetus. Then the part of the innovator the Spanish physician played in describing the minor circulation is being examined alongside the contributions made by other contemporary physicians who tried to explain this physiological process. The ideas of the philosophical anthropology of Servetus are represented with special stress of the fact that beyond the theological frame, in his main opus Christianismi restitutio there are typical characteristics from the Renaissance (i.e. ethic relativism etc.). At the end it becomes clear that the description of the minor circulation is only to serve the purpose of explaining Servetus's theological thesis according to which the seat of the soul is in the blood. He stipulates that the "sensible soul" is to be found in the choroidal plexus of the ventricles of the brain or else in the pineal gland. It is one of the merits of Servetus, too, that he had foreseen the capillaries (capillares) which he describes as well in the case of the lung vessels as in the case of the choroidal plexus in the brain. The last part deals with the history and background of the new edition of Christianismi restitutio, published 1790 in Nuremberg, which again is based on some recent archival research. PMID:6085975

  2. A Cation-Directed Enantioselective Sulfur-Mediated Michael/Mannich Three-Component Domino Reaction involving Chalcones as Michael Acceptors.

    PubMed

    Ding, Ran; Zheng, Bo; Wang, Yan; Peng, Yungui

    2015-09-01

    A new approach has been developed for an asymmetric sulfur-mediated three-component intermolecular Michael/Mannich domino reaction using chalcones as Michael acceptors. This reaction is catalyzed by chiral quaternary ammonium salts derived from modified quinine and provides facile access to complex sulfur-containing compounds with three contiguous stereogenic centers in yields of up to 93%, with 95:5 dr and 95% ee. These compounds were further elaborated to give the equivalent of a chiral aza-Morita-Baylis-Hillman reaction involving chalcones and azetidines bearing four chiral centers. PMID:26295594

  3. Space Launch Initiative: New Capabilities ... New Horizons

    NASA Technical Reports Server (NTRS)

    Dumbacher, Daniel L.

    2002-01-01

    This paper presents NASA's Space Launch Initiative (SLI) with new capabilities and new horizons. The topics include: 1) Integrated Space Transportation Plan; 2) SLI: The Work of an Nation; 3) SLI Goals and Status; 4) Composites and Materials; and 5) SLI & DoD/USAF Collaboration. This paper is presented in viewgraph form.

  4. Space Launch Initiative: New Capabilities - New Horizons

    NASA Technical Reports Server (NTRS)

    Dumbacher, Daniel; Smith, Dennis E. (Technical Monitor)

    2002-01-01

    This paper presents NASA's Space Launch Initiative (SLI) with new capabilities and new horizons. The topics include: 1) Integrated Space Transportation Plan; 2) SLI: The Work of a Nation; 3) SLI Goals and Status; 4) Composites and Materials; and 5) SLI and DOD/USAF Collaboration. This paper is in viewgraph form.

  5. Automatic star-horizon angle measurement system

    NASA Technical Reports Server (NTRS)

    Koerber, K.; Koso, D. A.; Nardella, P. C.

    1969-01-01

    Automatic star horizontal angle measuring aid for general navigational use incorporates an Apollo type sextant. The eyepiece of the sextant is replaced with two light detectors and appropriate circuitry. The device automatically determines the angle between a navigational star and a unique point on the earths horizon as seen on a spacecraft.

  6. The NMC Horizon Report: 2013 Museum Edition

    ERIC Educational Resources Information Center

    Johnson, L.; Adams Becker, S.; Freeman, A.

    2013-01-01

    The "NMC Horizon Report: 2013 Museum Edition," is a co-production with the Marcus Institute for Digital Education in the Arts (MIDEA), and examines six emerging technologies for their potential impact on and use in education and interpretation within the museum environment: BYOD (Bring Your Own Device), crowdsourcing, electronic…

  7. Gateway's Horizon: A Center of Excellence

    ERIC Educational Resources Information Center

    Herring, Jayne; Colony, Lee

    2007-01-01

    This article describes Gateway Technical College's Horizon Center for Transportation Technology, located in Kenosha, Wisconsin, which was the product of collaboration with business and industry, community support and a U.S. Department of Labor (DOL) grant. The center, which opened this fall, is a prime example of a sustainable community…

  8. On the differentiability order of horizons

    NASA Astrophysics Data System (ADS)

    Szeghy, D.

    2016-06-01

    Let M be a time oriented Lorentzian manifold and H\\subset M a horizon. We will show that the differentiability order of the horizon can change only once along a generator, i.e. the following holds. If γ :I\\to H is a generator, thus, an inextendable past directed light-like geodesic on the horizon, where I=(α ,β ) or [α ,β ), then there exists a unique parameter {t}0\\in [α ,β ] and a positive integer k≥slant 1 such that the following is true. The horizon H is exactly of class {C}k at γ (t), for every t\\in ({t}0,β ), moreover H is only differentiable, but not of class {C}1 at every point γ (t), for which t\\in (α ,{t}0]. Moreover, if γ (α ) is the endpoint of only one generator then for a suitable space-like submanifold R\\subset H the first cut point of R along γ is γ (α ). Furthermore, all the points γ (t), for which t\\in [α ,{t}0], are non-injectivity points of R along γ . Moreover, if H is smooth at an interior point of γ, then H is smooth at every point of γ. MSC 53C50

  9. New Concepts on the Educational Horizon.

    ERIC Educational Resources Information Center

    Gilchrist, Robert S.; Mitchell, Edna

    Four dimensions in education provide a basis for discussing future horizons: (1) curriculum development, (2) teacher education, (3) administration and organization, and (4) research and development. These areas are interdependent, and one cannot be improved or changed without affecting the other areas. Within these areas, some of the broad changes…

  10. New Horizons in Mathematics and Science Education.

    ERIC Educational Resources Information Center

    Thorson, Annette, Ed.

    2001-01-01

    This journal, intended for classroom teachers, provides a collection of essays organized around the theme of new horizons in mathematics and science education as well as a guide to instructional materials related to the theme. Topics addressed in the essays include digital libraries, the future of science curricula, integrated curricula, and…

  11. Agriculture’s Ethical Horizon, book review

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Roughly 6.5 billion people inhabit the earth, but over 1 billion people regularly go hungry. This food shortfall poses an ethical dilemma for agriculture, and Agriculture's Ethical Horizon grapples with this dilemma. It argues that agricultural productivity has been the quintessential value of agr...

  12. Dr. Michael DeBakey "is a magician of the heart…"

    MedlinePlus

    ... H. Gibbon, an American surgeon, first uses a mechanical heart and blood purifier. — 1961 J. R. Jude, ... Michael DeBakey and Adrian Kantrowitz, American surgeons, implant mechanical devices to help a diseased heart. — 1967 Christiaan ...

  13. Helical-Peptide-Catalyzed Enantioselective Michael Addition Reactions and Their Mechanistic Insights.

    PubMed

    Ueda, Atsushi; Umeno, Tomohiro; Doi, Mitsunobu; Akagawa, Kengo; Kudo, Kazuaki; Tanaka, Masakazu

    2016-08-01

    Helical peptide foldamer catalyzed Michael addition reactions of nitroalkane or dialkyl malonate to α,β-unsaturated ketones are reported along with the mechanistic considerations of the enantio-induction. A wide variety of α,β-unsaturated ketones, including β-aryl, β-alkyl enones, and cyclic enones, were found to be catalyzed by the helical peptide to give Michael adducts with high enantioselectivities (up to 99%). On the basis of X-ray crystallographic analysis and depsipeptide study, the amide protons, N(2)-H and N(3)-H, at the N terminus in the α-helical peptide catalyst were crucial for activating Michael donors, while the N-terminal primary amine activated Michael acceptors through the formation of iminium ion intermediates. PMID:27384597

  14. Chiral Aminophosphines as Catalysts for Enantioselective Double-Michael Indoline Syntheses

    PubMed Central

    Khong, San N.; Kwon, Ohyun

    2014-01-01

    The bisphosphine-catalyzed double-Michael addition of dinucleophiles to electron-deficient acetylenes is an efficient process for the synthesis of many nitrogen-containing heterocycles. Because the resulting heterocycles contain at least one stereogenic center, this double-Michael reaction would be even more useful if an asymmetric variant of the reaction were to be developed. Aminophosphines can also facilitate the double-Michael reaction and chiral amines are more readily available in Nature and synthetically; therefore, in this study we prepared several new chiral aminophosphines. When employed in the asymmetric double-Michael reaction between ortho-tosylamidophenyl malonate and 3-butyn-2-one, the chiral aminophosphines produced indolines in excellent yields with moderate asymmetric induction. PMID:22580397

  15. Tandem bis-aza-Michael addition reaction of amines in aqueous medium promoted by polystyrenesulfonic Acid

    EPA Science Inventory

    An efficient and environmentally benign tandem bis-aza-Michael addition of amines catalyzed by polystyrene sulfonic acid (PSSA) is described. This operationally simple high yielding microwave assisted synthetic protocol proceeded in water in the absence of any organic solvent.

  16. Michael J. Fox: Spurring Research on Parkinson's | NIH MedlinePlus the Magazine

    MedlinePlus

    ... of this page please turn JavaScript on. Feature: Parkinson's Disease Michael J. Fox: Spurring Research on Parkinson's Past ... found a richness of soul." Some celebrities with Parkinson's disease Bob Hoskins — Retired, award-winning English actor Photo ...

  17. Apparent horizons in binary black hole spacetimes

    NASA Astrophysics Data System (ADS)

    Shoemaker, Deirdre Marie

    Over the last decade, advances in computing technology and numerical techniques have lead to the possible theoretical prediction of astrophysically relevant waveforms in numerical simulations. With the building of gravitational wave detectors such as the Laser Interferometric Gravitational-Wave Observatory, we stand at the epoch that will usher in the first experimental study of strong field general relativity. One candidate source for ground based detection of gravitational waveforms, the orbit and merger of two black holes, is of great interest to the relativity community. The binary black hole problem is the two-body problem in general relativity. It is a stringent dynamical test of the theory. The problem involves the evolution of the Einstein equation, a complex system of non-linear, dynamic, elliptic-hyperbolic equations intractable in closed form. Numerical relativists are now developing the technology to evolve the Einstein equation using numerical simulations. The generation of these numerical I codes is a ``theoretical laboratory'' designed to study strong field phenomena in general relativity. This dissertation reports the successful development and application of the first multiple apparent horizon tracker applied to the generic binary black hole problem. I have developed a method that combines a level set of surfaces with a curvature flow method. This method, which I call the level flow method, locates the surfaces of any apparent horizons in the spacetime. The surface location then is used to remove the singularities from the computational domain in the evolution code. I establish the following set of criteria desired in an apparent horizon tracker: (1)The robustness of the tracker due to its lack of dependence on small changes to the initial guess; (2)The generality of the tracker in its applicability to generic spacetimes including multiple back hole spacetimes; and (3)The efficiency of the tracker algorithm in CPU time. I demonstrate the apparent

  18. The Pluto System As Seen By New Horizons Spacecraft

    NASA Video Gallery

    The Pluto system as NASA’s New Horizons spacecraft saw it in July 2015. This animation, made with real images taken by New Horizons, begins with Pluto flying in for its close-up on July 14; we then...

  19. SETAC launches global horizon scanning/research prioritization project

    EPA Science Inventory

    The SETAC World Council is pleased to announce the initiation of a Global Horizon Scanning and Prioritization Project aimed at identifying geographically specific research needs to address stressor impacts on environmental quality. In recent years, horizon scanning and research ...

  20. Rindler-like Horizon in Spherically Symmetric Spacetime

    NASA Astrophysics Data System (ADS)

    Yang, Jinbo; He, Tangmei; Zhang, Jingyi

    2016-02-01

    In this paper, the Rindler-like horizon in a spherically symmetric spacetime is proposed. It is showed that just like the Rindler horizon in Minkowski spacetimes, there is also a Rindler-like horizon to a family of special observers in general spherically symmetric spacetimes. The entropy of this type of horizon is calculated with the thin film brick-wall model. The significance of entropy is discussed. Our results imply some connection between Bekeinstein-Hawking entropy and entanglement entropy.

  1. Rindler-like Horizon in Spherically Symmetric Spacetime

    NASA Astrophysics Data System (ADS)

    Yang, Jinbo; He, Tangmei; Zhang, Jingyi

    2016-07-01

    In this paper, the Rindler-like horizon in a spherically symmetric spacetime is proposed. It is showed that just like the Rindler horizon in Minkowski spacetimes, there is also a Rindler-like horizon to a family of special observers in general spherically symmetric spacetimes. The entropy of this type of horizon is calculated with the thin film brick-wall model. The significance of entropy is discussed. Our results imply some connection between Bekeinstein-Hawking entropy and entanglement entropy.

  2. Status of the JPL Horizons Ephemeris System

    NASA Astrophysics Data System (ADS)

    Giorgini, Jon D.

    2015-08-01

    Since 1996, the NASA/Jet Propulsion Laboratory on-line Horizons system has provided open access to the latest JPL orbit solutions through customizable ephemeris generation and searches. Currently, high-precision ephemerides for more than 683,000 objects are available: all known solar system bodies, several dozen spacecraft, system barycenters, and some libration points.Since inception, Horizons has produced 150 million ephemeris products in response to 70.4 million connections by 800,000 unique IP addresses. Recent usage is typically 6000 unique users requesting 4,000,000 ephemeris products per month.Horizons is freely accessible without an account and may be used and automated through any of three interfaces: interactive telnet connection, web-browser form, or by sending e-mail command-files.Asteroid and comet ephemerides are numerically integrated on request using JPL's DASTCOM5 database of initial conditions which is kept current by a separate process; as new measurements and discoveries are reported by the Minor Planet Center, they are automatically processed into new JPL orbit solutions. Radar targets and other objects of high interest have their orbit solutions manually examined and updated into the database.For asteroids and comets, SPK files may be dynamically created using Horizons. This is effectively a recording of the integrator output. The binary files may then be efficiently interpolated by user software to exactly reproduce the trajectory without having to duplicate the numerically integrated n-body dynamical model or PPN equations of motion.Other Horizons output is numerical and in the form of plain-text observer, vector, osculating element, and close-approach tables. More than one hundred quantities can be requested in various time-scales and coordinate systems. For asteroids and comets, statistical uncertainties can be mapped to output times to assess position and motion uncertainties.Horizons is consistent with the DE431 solar system solution

  3. Rogue events in the group velocity horizon

    PubMed Central

    Demircan, Ayhan; Amiranashvili, Shalva; Brée, Carsten; Mahnke, Christoph; Mitschke, Fedor; Steinmeyer, Günter

    2012-01-01

    The concept of rogue waves arises from a mysterious and potentially calamitous phenomenon of oceanic surfaces. There is mounting evidence that they are actually commonplace in a variety of different physical settings. A set of defining criteria has been advanced; this set is of great generality and therefore applicable to a wide class of systems. The question arises naturally whether there are generic mechanisms responsible for extreme events in different systems. Here we argue that under suitable circumstances nonlinear interaction between weak and strong waves results in intermittent giant waves with all the signatures of rogue waves. To obtain these circumstances only a few basic conditions must be met. Then reflection of waves at the so-called group-velocity horizon occurs. The connection between rogue waves and event horizons, seemingly unrelated physical phenomena, is identified as a feature common in many different physical systems. PMID:23152941

  4. Horizon ratio bound for inflationary fluctuations.

    PubMed

    Dodelson, Scott; Hui, Lam

    2003-09-26

    We demonstrate that the gravity wave background amplitude implies a robust upper bound on the wavelength-to-horizon ratio at the end of inflation: lambda/H(-1) less than or approximately equal e(60), as long as the cosmic energy density does not drop faster than radiation subsequent to inflation. This limit implies that N, the number of e-folds between horizon exit and the end of inflation for wave modes of interest, is less, similar 60 plus a model-dependent factor-for vast classes of slow-roll models, N less than or approximately equal 67. As an example, this bound solidifies the tension between observations of the cosmic microwave background anisotropies and chaotic inflation with a phi(4) potential by closing the escape hatch of large N (<62). PMID:14525296

  5. Horizon Missions Technology Study. [for space exploration

    NASA Technical Reports Server (NTRS)

    Anderson, John L.

    1992-01-01

    The purpose of the HMT Study was to develop and demonstrate a systematic methodology for identifying and evaluating innovative technology concepts offering revolutionary, breadkthrough-type capabilities for advanced space missions and for assessing their potential mission impact. The methodology is based on identifying the new functional, operational and technology capabilities needed by hypothetical 'Horizon' space missions that have performance requirements that cannot be met, even by extrapolating known space technologies. Nineteen Horizon Missions were selected to represent a collective vision of advanced space missions of the mid-21st century. The missions typically would occur beyond the lifetime of current or planned space assets. The HM methodology and supporting data base may be used for advanced technology planning, advanced mission planning and multidisciplinary studies and analyses.

  6. Dynamical AdS strings across horizons

    NASA Astrophysics Data System (ADS)

    Ishii, Takaaki; Murata, Keiju

    2016-03-01

    We examine the nonlinear classical dynamics of a fundamental string in anti-de Sitter spacetime. The string is dual to the flux tube between an external quark-antiquark pair in {N}=4 super Yang-Mills theory. We perturb the string by shaking the endpoints and compute its time evolution numerically. We find that with sufficiently strong perturbations the string continues extending and plunges into the Poincaré horizon. In the evolution, effective horizons are also dynamically created on the string worldsheet. The quark and antiquark are thus causally disconnected, and the string transitions to two straight strings. The forces acting on the endpoints vanish with a power law whose slope depends on the perturbations. The condition for this transition to occur is that energy injection exceeds the static energy between the quark-antiquark pair.

  7. Horizon crossing and inflation with large {eta}

    SciTech Connect

    Kinney, William H.

    2005-07-15

    I examine the standard formalism of calculating curvature perturbations in inflation at horizon crossing, and derive a general relation which must be satisfied for the horizon-crossing formalism to be valid. This relation is satisfied for the usual cases of power-law and slow-roll inflation. I then consider a model for which the relation is strongly violated, and the curvature perturbation evolves rapidly on superhorizon scales. This model has Hubble slow-roll parameter {eta}=3, but predicts a scale-invariant spectrum of density perturbations. I consider the case of hybrid inflation with large {eta}, and show that such solutions do not solve the '{eta} problem' in supergravity. These solutions correspond to field evolution which has not yet relaxed to the inflationary attractor solution, and may make possible new, more natural models on the string landscape.

  8. Finding apparent horizons in numerical relativity

    NASA Astrophysics Data System (ADS)

    Thornburg, Jonathan

    1996-10-01

    We review various algorithms for finding apparent horizons in 3+1 numerical relativity. We then focus on one particular algorithm, in which we pose the apparent horizon equation H≡∇ini+Kijninj-K=0 as a nonlinear elliptic (boundary-value) PDE on angular-coordinate space for the horizon shape function r=h(θ,φ), finite difference this PDE, and use Newton's method or a variant to solve the finite difference equations. We describe a method for computing the Jacobian matrix of the finite differenced H(h) sH (sh) function by symbolically differentiating the finite difference equations, giving the Jacobian elements directly in terms of the finite difference molecule coefficients used in computing sH (sh). Assuming the finite differencing scheme commutes with linearization, we show how the Jacobian elements may be computed by first linearizing the continuum H(h) equations, then finite differencing the linearized continuum equations. (This is essentially just the ``Jacobian part'' of the Newton-Kantorovich method for solving nonlinear PDEs.) We tabulate the resulting Jacobian coefficients for a number of different sH (sh) and Jacobian computation schemes. We find this symbolic differentiation method of computing the Jacobian to be much more efficient than the usual numerical-perturbation method, and also much easier to implement than is commonly thought. When solving the discrete sH (sh)=0 equations, we find that Newton's method generally shows robust convergence. However, we find that it has a small (poor) radius of convergence if the initial guess for the horizon position contains significant high-spatial-frequency error components, i.e., angular Fourier components varying as (say) cosmθ with m>~8. (Such components occur naturally if spacetime contains significant amounts of high-frequency gravitational radiation.) We show that this poor convergence behavior is not an artifact of insufficient resolution in the finite difference grid; rather, it appears to be caused

  9. New Horizons Pluto Flyby Guest Operations

    NASA Astrophysics Data System (ADS)

    Simon, M.; Turney, D.; Fisher, S.; Carr, S. S.

    2015-12-01

    On July 14, 2015, after 9.5 years of cruise, NASA's New Horizons spacecraft flew past the Pluto system to gather first images humankind had ever seen on Pluto and its five moons. While much has been discovered about the Pluto system since New Horizons launch in 2006, the system has never been imaged at high resolution and anticipation of the "First Light" of the Pluto system had been anticipated by planetary enthusiasts for decades. The Johns Hopkins Applied Physics Laboratory (APL), which built and operates New Horizons, was the focal point for gathering three distinct groups: science and engineering team members; media and public affairs representatives; and invited public, including VIP's. Guest operations activities were focused on providing information primarily to the invited public and VIP's. High level objectives for the Guest Operations team was set to entertain and inform the general public, offer media reaction shots, and to deconflict activities for the guests from media activities wherever possible. Over 2000 people arrived at APL in the days surrounding closest approach for guest, science or media operations tracks. Reaction and coverage of the Guest Operations events was universally positive and global in impact: iconic pictures of the auditorium waving flags during the moment of closest approach were published in media outlets on every continent. Media relations activities ensured coverage in all key media publications targeted for release, such as the New York Times, Science, Le Monde, and Nature. Social and traditional media coverage of the events spanned the globe. Guest operations activities are designed to ensure that a guest has a memorable experience and leaves with a lifelong memory of the mission and their partnership in the activity. Results, lessons learned, and other data from the New Horizons guest operations activity will be presented and analyzed.

  10. Finding KBO flyby targets for New Horizons

    NASA Astrophysics Data System (ADS)

    Spencer, John; Trilling, David; Buie, Marc; Parker, Alex; Tholen, David; Stern, S. Alan

    2014-02-01

    We propose to continue the search for Kuiper Belt Objects (KBOs) that can be reached by the New Horizons spacecraft after its 2015 Pluto flyby. This first flyby of a small (~50 km) KBO would revolutionize our understanding of KBOs, providing information that can be extrapolated to hundreds of thousands of similar KBOs. Our 2011 search discovered three objects that could be targeted with only about twice the fuel that New Horizons has available during excellent seeing, but seeing was insufficient to achieve this depth over the entire search area in 2012 or 2013. Deepening the search in 2014, taking advantage of lower star density and the shrinking search area, has a good chance of finding a targetable object given sufficiently good seeing, especially with Hyper Suprime Cam. We expect about 2.5 targetable objects with R less 26.0 in the HSC field of view. We will also refine the orbits of previously discovered objects, including ones that can be observed from a distance by New Horizons on its passage through the Kuiper Belt.

  11. Finding KBO flyby targets for New Horizons

    NASA Astrophysics Data System (ADS)

    Spencer, John; Trilling, David; Buie, Marc; Parker, Alex; Tholen, David; Stern, S. Alan

    2014-08-01

    We propose to continue the search for Kuiper Belt Objects (KBOs) that can be reached by the New Horizons spacecraft after its 2015 Pluto flyby, by following up on KBOs discovered in 2014A. The first flyby of a small (~50 km) KBO would revolutionize our understanding of KBOs, providing information that can be extrapolated to hundreds of thousands of similar KBOs. Our 2011 search discovered two objects that could be targeted with less than twice the fuel that New Horizons has available, during excellent seeing, but seeing was insufficient to achieve this depth over the entire search area in 2012 or 2013. Deepening the search with time allocated in 2014A, taking advantage of lower star density and the shrinking search area, has a chance of finding a targetable object given sufficiently good seeing, especially with Hyper Suprime Cam. 2014B follow-up is essential to produce orbits good enough to determine targetability, and allow recovery in 2015. We will also continue to refine the orbits of other previously discovered objects, including ones that can be observed from a distance by New Horizons on its passage through the Kuiper Belt.

  12. Accurate, reliable prototype earth horizon sensor head

    NASA Technical Reports Server (NTRS)

    Schwarz, F.; Cohen, H.

    1973-01-01

    The design and performance is described of an accurate and reliable prototype earth sensor head (ARPESH). The ARPESH employs a detection logic 'locator' concept and horizon sensor mechanization which should lead to high accuracy horizon sensing that is minimally degraded by spatial or temporal variations in sensing attitude from a satellite in orbit around the earth at altitudes in the 500 km environ 1,2. An accuracy of horizon location to within 0.7 km has been predicted, independent of meteorological conditions. This corresponds to an error of 0.015 deg-at 500 km altitude. Laboratory evaluation of the sensor indicates that this accuracy is achieved. First, the basic operating principles of ARPESH are described; next, detailed design and construction data is presented and then performance of the sensor under laboratory conditions in which the sensor is installed in a simulator that permits it to scan over a blackbody source against background representing the earth space interface for various equivalent plant temperatures.

  13. Horizon Science Experiment for Mars Global Surveyor

    NASA Astrophysics Data System (ADS)

    Martin, T. Z.

    1997-07-01

    The Mars Horizon Sensor Assembly on the MGS orbiter monitors the orientation of the spacecraft relative to the limb by sensing atmospheric emission in the 15 mu m CO2 band. These data are used to maintain nadir pointing for the remote sensing instrument suite. The set of 5.5deg tall triangular fields of view normally straddle the limb, and cover quadrants 90deg apart around the limb. As an engineering device, the MHSA benefits from Mars' atmosphere being spatially bland at 15 mu m. However, these data will carry information about the thermal state of the atmosphere, which is subject to diurnal, seasonal, latitudinal, and dust-storm related variations, as well as possible wave effects. The Mariner 7 IRS, Mariner 9 IRIS, and Viking IRTM all demonstrated such variability. The Horizon Science Experiment (HORSE) is intended to glean new insight into atmospheric variation from the MGS horizon sensors, with continuous data flow to the Earth in the engineering stream, and a rapid buildup of spatial coverage. MHSA data will also be used to monitor atmospheric thermal behavior during the aerobraking of MGS in late 1997.

  14. The Cinnamon-derived Michael Acceptor Cinnamic Aldehyde Impairs Melanoma Cell Proliferation, Invasiveness, and Tumor Growth

    PubMed Central

    Cabello, Christopher M.; Bair, Warner B.; Lamore, Sarah D.; Ley, Stephanie; Bause, Alexandra S.; Azimian, Sara; Wondrak, Georg T.

    2009-01-01

    Redox dysregulation in cancer cells represents a chemical vulnerability that can be targeted by prooxidant redox intervention. Dietary constituents that contain an electrophilic Michael acceptor pharmacophore may therefore display promising chemopreventive and chemotherapeutic anti-cancer activity. Here, we demonstrate that the cinnamon-derived dietary Michael acceptor trans-cinnamic aldehyde (CA) impairs melanoma cell proliferation and tumor growth. Feasibility of therapeutic intervention using high doses of CA (120 mg/kg, p.o., q.d., 10 days) was demonstrated in a human A375 melanoma SCID-mouse xenograft model. Low micromolar concentrations (IC50 < 10 μM) of CA, but not closely related CA-derivatives devoid of Michael acceptor activity, suppressed proliferation of human metastatic melanoma cell lines (A375, G361, LOX) with G1 cell cycle arrest, elevated intracellular ROS, and impaired invasiveness. Expression array analysis revealed that CA induced an oxidative stress response in A375 cells, up-regulating heme oxygenase-1 (HMOX1), sulfiredoxin 1 homolog (SRXN1), thioredoxin reductase 1 (TXNRD1), and other genes including the cell cycle regulator and stress-responsive tumor suppressor gene cyclin-dependent kinase inhibitor 1A (CDKN1A), a key mediator of G1 phase arrest. CA, but not Michael-inactive derivatives, inhibited NFκB transcriptional activity and TNFα-induced IL-8 production in A375 cells. These findings support a previously unrecognized role of CA as a dietary Michael acceptor with potential anticancer activity. PMID:19000754

  15. TUTORIAL ON NETWORK GENOMICS.

    SciTech Connect

    Forst, C.

    2001-01-01

    With the ever-increasing genomic information pouring into the databases researchers start to look for pattern in genomes. Key questions are the identification of function. In the past function was mainly understood to be assigned to a single gene isolated from other cellular components or mechanisms. Sequence comparison fo single genes and their products (proteins) as well as of intergenic space are a consequence of a well established one-gene one-function interpretation. prediction of function solely by sequence similarity searches are powerful techniques that initiated the advent of bioinformatics and computational biology. Seminal work on sequence alignment by Temple Smith and Michael Waterman [33] and sequence searches with the BLAST algorithm by Altschul et al. [2] provide essential methods for sequence based determination of function. Similar outstanding contributions to determination of function have been archived in the area of structure prediction, molecular modeling and molecular dynamics. Techniques covering ab initio and homology modeling up to biophysical interpretation of long-run molecular dynamics simulations are mentioned ehre. With the ever-increasing number of information of different genetic/genomic origin, new aspect are looked for that deviate from the single gene at a time method. Especially with the identification of surprisingly few human genes the emerging perception in the scientific community that the concept of function has to be extended to include other sequence based as well as non-sequenced based information. A schema of determination of function by different concepts is shown in Figure 1. The tutorial is comprised of the following sections: The first two sections discuss the differences between genomic and non-genomic based context information, section three will cover combined methods. Finally, section four lsits web-resources and databases. All presented approaches extensively employ comparative methods.

  16. X-24B with Test Pilot Michael V. Love

    NASA Technical Reports Server (NTRS)

    1973-01-01

    This photo shows Air Force Lieutenant Colonel Michael V. Love in front of the X-24B lifting-body research vehicle at Edwards Air Force Base in 1973. Love was assigned as a project pilot on the joint NASA-USAF X-24B Lifting Body flight test program at the NASA Flight Research Center. He made a total of 12 flights in the plane from October 4, 1973 until July 15, 1975. Love flew it to a speed of Mach 1.76 on October 25, 1974, a record for the X-24B. Love attended the USAF Test Pilot School and remained as an instructor there from 1969 through 1971. He was a test pilot at Edwards when assigned to fly to the X-24B. Love was a combat veteran of Vietnam and was awarded the Distinguished Flying Cross with two Oak Leaf clusters. Love perished while attempting an emergency landing in an RF-4C on March 1, 1976. The X-24B was the last aircraft to fly in the Dryden Flight Research Center's manned lifting body program. The X-24 was one of a group of lifting bodies flown by the NASA Flight Research Center (now Dryden Flight Research Center), Edwards, California, in a joint program with the U.S. Air Force at Edwards Air Force Base from 1963 to 1975. The lifting bodies were used to demonstrate the ability of pilots to maneuver and safely land wingless vehicles designed to fly back to Earth from space and be landed like an airplane at a predetermined site. Lifting bodies' aerodynamic lift, essential to flight in the atmosphere, was obtained from their shape. The addition of fins and control surfaces allowed the pilots to stabilize and control the vehicles and regulate their flight paths. Built by Martin Aircraft Company, Maryland, for the U.S. Air Force, the X-24A was a bulbous vehicle shaped like a teardrop with three vertical fins at the rear for directional control. It weighed 6,270 pounds, was 24.5 feet long and 11.5 feet wide (measuring just the fuselage, not the distance between the tips of the outboard fins). Its first unpowered glide flight was on April 17, 1969, with Air

  17. Incorporation of a Michael acceptor enhances the antitumor activity of triterpenoic acids.

    PubMed

    Heller, Lucie; Schwarz, Stefan; Perl, Vincent; Köwitsch, Alexander; Siewert, Bianka; Csuk, René

    2015-08-28

    Finding and developing drugs for the treatment of cancer has been challenging scientists for many decades, and using compounds of natural origin represents one of several strategies. Triterpenoic acids are a very promising class of secondary metabolites being able to induce apoptosis while their cytotoxicity is low. Therefore, derivatizations have to be conducted to improve cytotoxicity while retaining their ability to induce programmed cell death. The incorporation of a Michael acceptor into molecules resulted very often in drugs of improved cytotoxicity. Thus, in this study we synthesized and evaluated several Michael acceptor substituted compounds derived from glycyrrhetinic, ursolic, oleanolic and platanic acid. The influence of the presence of such a functional group onto the cytotoxicity was investigated in colorimetric sulforhodamine B assays employing several human cancer cell lines. EC50 values in the single-digit micromolar range were measured. Thus, the incorporation of a Michael acceptor unit into triterpenoic acids enhances the cytotoxicity of these compounds significantly. PMID:26177446

  18. Time Horizon and Social Scale in Communication

    NASA Astrophysics Data System (ADS)

    Krantz, D. H.

    2010-12-01

    In 2009 our center (CRED) published a first version of The Psychology of Climate Change Communication. In it, we attempted to summarize facts and concepts from psychological research that could help guide communication. While this work focused on climate change, most of the ideas are at least partly applicable for communication about a variety of natural hazards. Of the many examples in this guide, I mention three. Single-action bias is the human tendency to stop considering further actions that might be needed to deal with a given hazard, once a single action has been taken. Another example is the importance of group affiliation in motivating voluntary contributions to joint action. A third concerns the finding that group participation enhances understanding of probabilistic concepts and promotes action in the face of uncertainty. One current research direction, which goes beyond those included in the above publication, focuses on how time horizons arise in the thinking of individuals and groups, and how these time horizons might influence hazard preparedness. On the one hand, individuals sometimes appear impatient, organizations look for immediate results, and officials fail to look beyond the next election cycle. Yet under some laboratory conditions and in some subcultures, a longer time horizon is adopted. We are interested in how time horizon is influenced by group identity and by the very architecture of planning and decision making. Institutional changes, involving long-term contractual relationships among communities, developers, insurers, and governments, could greatly increase resilience in the face of natural hazards. Communication about hazards, in the context of such long-term contractual relationships might look very different from communication that is first initiated by immediate threat. Another new direction concerns the social scale of institutions and of communication about hazards. Traditionally, insurance contracts share risk among a large

  19. The horizon of the lightest black hole

    NASA Astrophysics Data System (ADS)

    Calmet, Xavier; Casadio, Roberto

    2015-09-01

    We study the properties of the poles of the resummed graviton propagator obtained by resumming bubble matter diagrams which correct the classical graviton propagator. These poles have been previously interpreted as black holes precursors. Here, we show using the horizon wave-function formalism that these poles indeed have properties which make them compatible with being black hole precursors. In particular, when modeled with a Breit-Wigner distribution, they have a well-defined gravitational radius. The probability that the resonance is inside its own gravitational radius, and thus that it is a black hole, is about one half. Our results confirm the interpretation of these poles as black hole precursors.

  20. Generic isolated horizons and their applications

    PubMed

    Ashtekar; Beetle; Dreyer; Fairhurst; Krishnan; Lewandowski; Wisniewski

    2000-10-23

    The notion of isolated horizons is extended to allow for distortion and rotation. Space-times containing a black hole, itself in equilibrium but possibly surrounded by radiation, satisfy these conditions. The framework has three types of applications: (i) it provides new tools to extract physics from strong field geometry; (ii) it leads to a generalization of the zeroth and first laws of black hole mechanics and sheds new light on the "origin" of the first law; and (iii) it serves as a point of departure for black hole entropy calculations in nonperturbative quantum gravity. PMID:11030951

  1. Peripheral Vision Horizon Display (PVHD). Corrected Copy

    NASA Technical Reports Server (NTRS)

    1984-01-01

    A Canadian invention, the peripheral vision horizon display (PVHD), shows promise in alleviating vertigo or disorientation in pilots flying under instrument conditions and easing the piloting task when flying in weather or other conditions requiring close attention to aircraft attitude instruments. A diversity of research and applied work was being done to investigate and validate the benefits of the PVHD during the years immediately preceding this conference. Organizers of the conference were able to assemble a group of outstanding presenters representing academic, industrial, and military. The theoretical foundation and applied use of the PVHD are discussed, and results from operational tests are presented.

  2. Art, the Urban Skyscraper, and Horizon Astronomy

    NASA Astrophysics Data System (ADS)

    Mooney, J. D.

    2016-01-01

    This presentation delineates the historiography and the iconography of my urban public sculptures which use skyscrapers as today's standing stones, markers for horizon astronomy. From 1977 to the present time, my work has engaged the public to “look up and see.” Through ephemeral works in the sky and over the water to large-scale rooftop sculptures in Los Angeles, Chicago, Atlanta, and Europe, viewers are oriented to the Milky Way, the summer triangle, and other celestial phenomena. This new urban scale art, transformative in context and gesture, has become part of the new cultural landscape.

  3. Prolate horizons and the Penrose inequality

    SciTech Connect

    Tippett, Benjamin K.

    2009-05-15

    The Penrose inequality has so far been proven in cases of spherical symmetry and in cases of zero extrinsic curvature. The next simplest case worth exploring would be nonspherical, nonrotating black holes with nonzero extrinsic curvature. Following Karkowski et al.'s construction of prolate black holes, we define initial data on an asymptotically flat spacelike 3-surface with nonzero extrinsic curvature that may be chosen freely. This gives us the freedom to define the location of the apparent horizon such that the Penrose inequality is violated. We show that the dominant energy condition is violated at the poles for all cases considered.

  4. Black hole thermodynamics from Euclidean horizon constraints.

    PubMed

    Carlip, S

    2007-07-13

    To explain black hole thermodynamics in quantum gravity, one must introduce constraints to ensure that a black hole is actually present. I show that for a large class of black holes, such "horizon constraints" allow the use of conformal field theory techniques to compute the density of states, reproducing the Bekenstein-Hawking entropy in a nearly model-independent manner. One standard string theory approach to black hole entropy arises as a special case, lending support to the claim that the mechanism may be "universal." I argue that the relevant degrees of freedom are Goldstone-boson-like excitations arising from the weak breaking of symmetry by the constraints. PMID:17678209

  5. European scientists' proposals for HORIZON 2000+

    NASA Astrophysics Data System (ADS)

    1994-10-01

    This programme, which has been given the name Horizon 2000+, will be presented to the press at 0900h on Monday 17 October 1994 at ESA Headquarters in Paris by Professor Lodewijk Woltjer, who chaired the committee of European scientific community representatives set up to consider the proposals submitted, and Professor Roger Bonnet, ESA's Science Programme Director. Journalists wishing to attend this press breakfast are requested to complete and return the attached form, if possible by fax: (33.1) 42.73.76.90.

  6. Aza-Michael Mono-addition Using Acidic Alumina under Solventless Conditions.

    PubMed

    Bosica, Giovanna; Abdilla, Roderick

    2016-01-01

    Aza-Michael reactions between primary aliphatic and aromatic amines and various Michael acceptors have been performed under environmentally-friendly solventless conditions using acidic alumina as a heterogeneous catalyst to selectively obtain the corresponding mono-adducts in high yields. Ethyl acrylate was the main acceptor used, although others such as acrylonitrile, methyl acrylate and acrylamide were also utilized successfully. Bi-functional amines also gave the mono-adducts in good to excellent yields. Such compounds can serve as intermediates for the synthesis of anti-cancer and antibiotic drugs. PMID:27338336

  7. Copper-catalyzed asymmetric conjugate addition of organometallic reagents to extended Michael acceptors

    PubMed Central

    Schmid, Thibault E; Drissi-Amraoui, Sammy; Crévisy, Christophe; Baslé, Olivier

    2015-01-01

    Summary The copper-catalyzed asymmetric conjugate addition (ACA) of nucleophiles onto polyenic Michael acceptors represents an attractive and powerful methodology for the synthesis of relevant chiral molecules, as it enables in a straightforward manner the sequential generation of two or more stereogenic centers. In the last decade, various chiral copper-based catalysts were evaluated in combination with different nucleophiles and Michael acceptors, and have unambiguously demonstrated their usefulness in the control of the regio- and enantioselectivity of the addition. The aim of this review is to report recent breakthroughs achieved in this challenging field. PMID:26734090

  8. 78 FR 54298 - Horizons ETFs Management (USA) LLC and Horizons ETF Trust; Notice of Application

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-03

    .... Applicants currently intend that the initial series of the Trust will be the Horizons Active Global Dividend... through either the NSCC or DTC; or (ii) in the case of Funds holding non-U.S. investment (``Global Funds... holder of Shares of a Global Fund would be subject to unfavorable income tax treatment if the...

  9. Killing horizons around a uniformly accelerating and rotating particle

    SciTech Connect

    Farhoosh, H.; Zimmerman, R.L.

    1980-08-15

    The structure of the Killing horizon surrounding a uniformly accelerating and rotating particle which is emitting gravitational radiation is investigated. When expressed in terms of a coordinate system which is rigidly fixed to the particle undergoing uniform acceleration, the two inner horizons and ergoregion are similar to the horizons and ergoregion in the Kerr solution. These compact surfaces are distorted by the acceleration, being elongated in the forward direction and contracted in the backward direction. In addition to the two horizons that are similar to the Kerr solution, there is an additional noncompact horizon and an additional ergoregion which are caused by the acceleration. In general, the two ergoregions are disjoint, but as the acceleration parameter is sufficiently increased these ergoregions coalesce. A further increase of the acceleration will cause the two outer horizons to become degenerate and the ergoregion to vanish. An increase in the rotation parameter causes effects similar to those in the Kerr metric.

  10. Killing horizons around a uniformly accelerating and rotating particle

    NASA Astrophysics Data System (ADS)

    Farhoosh, Hamid; Zimmerman, Robert L.

    1980-08-01

    The structure of the Killing horizon surrounding a uniformly accelerating and rotating particle which is emitting gravitational radiation is investigated. When expressed in terms of a coordinate system which is rigidly fixed to the particle undergoing uniform acceleration, the two inner horizons and ergoregion are similar to the horizons and ergoregion in the Kerr solution. These compact surfaces are distorted by the acceleration, being elongated in the forward direction and contracted in the backward direction. In addition to the two horizons that are similar to the Kerr solution, there is an additional noncompact horizon and an additional ergoregion which are caused by the acceleration. In general, the two ergoregions are disjoint, but as the acceleration parameter is sufficiently increased these ergoregions coalesce. A further increase of the acceleration will cause the two outer horizons to become degenerate and the ergoregion to vanish. An increase in the rotation parameter causes effects similar to those in the Kerr metric.

  11. Gribov's horizon and the ghost dressing function

    SciTech Connect

    Boucaud, Ph.; Leroy, J. P.; Le Yaouanc, A.; Micheli, J.; Pene, O.; Rodriguez-Quintero, J.

    2009-11-01

    We study a relation recently derived by K. Kondo at zero momentum between the Zwanziger's horizon function, the ghost dressing function and Kugo's functions u and w. We agree with this result as far as bare quantities are considered. However, assuming the validity of the horizon gap equation, we argue that the solution w(0)=0 is not acceptable since it would lead to a vanishing renormalized ghost dressing function. On the contrary, when the cutoff goes to infinity, u(0){yields}{infinity}, w(0){yields}-{infinity} such that u(0)+w(0){yields}-1. Furthermore w and u are not multiplicatively renormalizable. Relaxing the gap equation allows w(0)=0 with u(0){yields}-1. In both cases the bare ghost dressing function, F(0,{lambda}), goes logarithmically to infinity at infinite cutoff. We show that, although the lattice results provide bare results not so different from the F(0,{lambda})=3 solution, this is an accident due to the fact that the lattice cutoffs lie in the range 1-3 GeV{sup -1}. We show that the renormalized ghost dressing function should be finite and nonzero at zero momentum and can be reliably estimated on the lattice up to powers of the lattice spacing; from published data on a 80{sup 4} lattice at {beta}=5.7 we obtain F{sub R}(0,{mu}=1.5 GeV){approx_equal}2.2.

  12. Energy and information near black hole horizons

    SciTech Connect

    Freivogel, Ben

    2014-07-01

    The central challenge in trying to resolve the firewall paradox is to identify excitations in the near-horizon zone of a black hole that can carry information without injuring a freely falling observer. By analyzing the problem from the point of view of a freely falling observer, I arrive at a simple proposal for the degrees of freedom that carry information out of the black hole. An infalling observer experiences the information-carrying modes as ingoing, negative energy excitations of the quantum fields. In these states, freely falling observers who fall in from infinity do not encounter a firewall, but freely falling observers who begin their free fall from a location close to the horizon are ''frozen'' by a flux of negative energy. When the black hole is ''mined,'' the number of information-carrying modes increases, increasing the negative energy flux in the infalling frame without violating the equivalence principle. Finally, I point out a loophole in recent arguments that an infalling observer must detect a violation of unitarity, effective field theory, or free infall.

  13. Cool horizons lead to information loss

    NASA Astrophysics Data System (ADS)

    Chowdhury, Borun D.

    2013-10-01

    There are two evidences for information loss during black hole evaporation: (i) a pure state evolves to a mixed state and (ii) the map from the initial state to final state is non-invertible. Any proposed resolution of the information paradox must address both these issues. The firewall argument focuses only on the first and this leads to order one deviations from the Unruh vacuum for maximally entangled black holes. The nature of the argument does not extend to black holes in pure states. It was shown by Avery, Puhm and the author that requiring the initial state to final state map to be invertible mandates structure at the horizon even for pure states. The proof works if black holes can be formed in generic states and in this paper we show that this is indeed the case. We also demonstrate how models proposed by Susskind, Papadodimas et al. and Maldacena et al. end up making the initial to final state map non-invertible and thus make the horizon "cool" at the cost of unitarity.

  14. 'The televising of science is a process of television': establishing Horizon, 1962-1967.

    PubMed

    Boon, Timothy

    2015-03-01

    BBC Television's Horizon series, fifty years old on 2 May 2014, despite its significance to the history of the public culture of science, has been little studied. This microhistorical account follows the gestation and early years of the programme, demonstrating how it established a social and cultural account of science. This was a result of televisual factors, notably the determination to follow the format of the successful arts television programme Monitor. It illuminates how the processes of television production, with a handful of key participants - Aubrey Singer, Gerald Leach, Philip Daly, Gordon Rattray Taylor, Ramsay Short, Michael Peacock and Robert Reid - established the format of the programme. This occurred over seventeen months of prior preparation followed by three troubled years of seeking to establish a stable form. This was finally achieved in 1967 when the programme adopted a film documentary approach after extended attempts at making it as a studio-based magazine programme. The story has implications for understanding the social accounts of science that were circulating in the key decade of the 1960s. PMID:25833799

  15. Radiation from quantum weakly dynamical horizons in loop quantum gravity.

    PubMed

    Pranzetti, Daniele

    2012-07-01

    We provide a statistical mechanical analysis of quantum horizons near equilibrium in the grand canonical ensemble. By matching the description of the nonequilibrium phase in terms of weakly dynamical horizons with a local statistical framework, we implement loop quantum gravity dynamics near the boundary. The resulting radiation process provides a quantum gravity description of the horizon evaporation. For large black holes, the spectrum we derive presents a discrete structure which could be potentially observable. PMID:23031096

  16. Dynamical horizons: energy, angular momentum, fluxes, and balance laws.

    PubMed

    Ashtekar, Abhay; Krishnan, Badri

    2002-12-23

    Dynamical horizons are considered in full, nonlinear general relativity. Expressions of fluxes of energy and angular momentum carried by gravitational waves across these horizons are obtained. Fluxes are local, the energy flux is positive, and change in the horizon area is related to these fluxes. The flux formulas also give rise to balance laws analogous to the ones obtained by Bondi and Sachs at null infinity and provide generalizations of the first and second laws of black-hole mechanics. PMID:12484807

  17. 76 FR 44901 - Californians for Renewable Energy, Inc., Michael E. Boyd, Robert M. Sarvey v. California Public...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-27

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Californians for Renewable Energy, Inc., Michael E. Boyd, Robert M. Sarvey v..., Californians for Renewable Energy, Inc. (CARE), acting on behalf of its members, Michael E. Boyd, and Robert...

  18. Decarboxylative 1,4-Addition of α-Oxocarboxylic Acids with Michael Acceptors Enabled by Photoredox Catalysis.

    PubMed

    Wang, Guang-Zu; Shang, Rui; Cheng, Wan-Min; Fu, Yao

    2015-10-01

    Enabled by iridium photoredox catalysis, 2-oxo-2-(hetero)arylacetic acids were decarboxylatively added to various Michael acceptors including α,β-unsaturated ester, ketone, amide, aldehyde, nitrile, and sulfone at room temperature. The reaction presents a new type of acyl Michael addition using stable and easily accessible carboxylic acid to formally generate acyl anion through photoredox-catalyzed radical decarboxylation. PMID:26366608

  19. 78 FR 2393 - CAlifornians for Renewable Energy, Inc., Michael E. Boyd, Robert M. Sarvey v. California Public...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-11

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission CAlifornians for Renewable Energy, Inc., Michael E. Boyd, Robert M. Sarvey v...), CAlifornians for Renewable Energy, Inc.; Michael E. Boyd; and Robert M. Sarvey filed a petition requesting...

  20. 76 FR 624 - Proposed Information Collection (Patient Satisfaction Survey Michael E. DeBakey Home Care Program...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-05

    ... AFFAIRS Proposed Information Collection (Patient Satisfaction Survey Michael E. DeBakey Home Care Program.... 2900-New (VA Form 10-0476).'' SUPPLEMENTARY INFORMATION: Title: Patient Satisfaction Survey Michael E... their satisfaction with the quality of services/care provided by home care program staff. An agency...

  1. 78 FR 6851 - Proposed Information Collection (Patient Satisfaction Survey Michael E. DeBakey Home Care Program...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-31

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF VETERANS AFFAIRS Proposed Information Collection (Patient Satisfaction Survey Michael E. DeBakey Home Care Program....'' SUPPLEMENTARY INFORMATION: Title: Patient Satisfaction Survey Michael E. DeBakey Home Care Program, VA Form...

  2. Horizons versus singularities in spherically symmetric space-times

    SciTech Connect

    Bronnikov, K. A.; Elizalde, E.; Odintsov, S. D.; Zaslavskii, O. B.

    2008-09-15

    We discuss different kinds of Killing horizons possible in static, spherically symmetric configurations and recently classified as 'usual', 'naked', and 'truly naked' ones depending on the near-horizon behavior of transverse tidal forces acting on an extended body. We obtain the necessary conditions for the metric to be extensible beyond a horizon in terms of an arbitrary radial coordinate and show that all truly naked horizons, as well as many of those previously characterized as naked and even usual ones, do not admit an extension and therefore must be considered as singularities. Some examples are given, showing which kinds of matter are able to create specific space-times with different kinds of horizons, including truly naked ones. Among them are fluids with negative pressure and scalar fields with a particular behavior of the potential. We also discuss horizons and singularities in Kantowski-Sachs spherically symmetric cosmologies and present horizon regularity conditions in terms of an arbitrary time coordinate and proper (synchronous) time. It turns out that horizons of orders 2 and higher occur in infinite proper times in the past or future, but one-way communication with regions beyond such horizons is still possible.

  3. Gravitational anomaly and Hawking radiation near a weakly isolated horizon

    SciTech Connect

    Wu Xiaoning; Huang Chaoguang; Sun Jiarui

    2008-06-15

    Based on the idea of the work by Wilczek and his collaborators, we consider the gravitational anomaly near a weakly isolated horizon. We find that there exists a universal choice of tortoise coordinate for any weakly isolated horizon. Under this coordinate, the leading behavior of a quite arbitrary scalar field near a horizon is a 2-dimensional chiral scalar field. This means we can extend the idea of Wilczek and his collaborators to more general cases and show the relation between gravitational anomaly and Hawking radiation is a universal property of a black hole horizon.

  4. Gravitational anomaly and Hawking radiation near a weakly isolated horizon

    NASA Astrophysics Data System (ADS)

    Wu, Xiaoning; Huang, Chao-Guang; Sun, Jia-Rui

    2008-06-01

    Based on the idea of the work by Wilczek and his collaborators, we consider the gravitational anomaly near a weakly isolated horizon. We find that there exists a universal choice of tortoise coordinate for any weakly isolated horizon. Under this coordinate, the leading behavior of a quite arbitrary scalar field near a horizon is a 2-dimensional chiral scalar field. This means we can extend the idea of Wilczek and his collaborators to more general cases and show the relation between gravitational anomaly and Hawking radiation is a universal property of a black hole horizon.

  5. Into the Kuiper Belt: New Horizons Post-Pluto

    NASA Astrophysics Data System (ADS)

    Harrison Parker, Alex; Spencer, John; Benecchi, Susan; Binzel, Richard; Borncamp, David; Buie, Marc; Fuentes, Cesar; Gwyn, Stephen; Kavelaars, JJ; Noll, Keith; Petit, Jean-Marc; Porter, Simon; Showalter, Mark; Stern, S. Alan; Sterner, Ray; Tholen, David; Verbiscer, Anne; Weaver, Hal; Zangari, Amanda

    2015-11-01

    New Horizons is now beyond Pluto and flying deeper into the Kuiper Belt. In the summer of 2014, a Hubble Space Telescope Large Program identified two candidate Cold Classical Kuiper Belt Objects (KBOs) that were within reach of New Horizons' remaining fuel budget. Here we present the selection of the Kuiper Belt flyby target for New Horizons' post-Pluto mission, our state of knowledge regarding this target and the potential 2019 flyby, the status of New Horizons' targeting maneuver, and prospects for near-future long-range observations of other KBOs.

  6. Criticality and surface tension in rotating horizon thermodynamics

    NASA Astrophysics Data System (ADS)

    Hansen, Devin; Kubizňák, David; Mann, Robert B.

    2016-08-01

    We study a modified horizon thermodynamics and the associated criticality for rotating black hole spacetimes. Namely, we show that under a virtual displacement of the black hole horizon accompanied by an independent variation of the rotation parameter, the radial Einstein equation takes a form of a ‘cohomogeneity two’ horizon first law, δ E=Tδ S+{{Ω }}δ J-σ δ A, where E and J are the horizon energy (an analogue of the Misner–Sharp mass) and the horizon angular momentum, Ω is the horizon angular velocity, A is the horizon area, and σ is the surface tension induced by the matter fields. For fixed angular momentum, the above equation simplifies and the more familiar (cohomogeneity one) horizon first law δ E=Tδ S-Pδ V is obtained, where P is the pressure of matter fields and V is the horizon volume. A universal equation of state is obtained in each case and the corresponding critical behavior is studied.

  7. Education, Philosophy and Politics: The Selected Works of Michael A. Peters. World Library of Educationalists

    ERIC Educational Resources Information Center

    Peters, Michael A.

    2012-01-01

    In the World Library of Educationalists series, international experts themselves compile career-long collections of what they judge to be their finest pieces--extracts from books, key articles, salient research findings, major theoretical and/practical contributions--so the world can read them in a single manageable volume. Michael A. Peters has…

  8. "The Politics of Faith and the Politics of Scepticism": Michael Oakeshott, Education and Extremism

    ERIC Educational Resources Information Center

    Frowe, Ian

    2007-01-01

    This paper considers a distinction between two types of politics developed by Michael Oakeshott in his book "The Politics of Faith and the Politics of Scepticism" (1996) and argues that the theoretical framework proposed supplies an illuminating and productive perspective for examining the notion of political extremism. These positions are linked…

  9. Wolff-Michael Roth's passibility: at the limits of the constructivist metaphor: a book review

    NASA Astrophysics Data System (ADS)

    Brendel, Michelle

    2014-12-01

    Wolff-Michael Roth deconstructs the preeminent role conceded to constructivism in Science Education and demonstrates how we learn and know through pain, suffering, love or passion. This review explores his book "Passibility: At the Limits of the Constructivist Metaphor" through the eyes of an outsider to the world of science education.

  10. Q & A with Ed Tech Leaders: Interview with Michael W. Allen

    ERIC Educational Resources Information Center

    Shaughnessy, Michael F.

    2014-01-01

    Michael W. Allen, the Chairman and CEO of Allen Interactions, is an architect of interactive multimedia learning and is recognized for his many insights, inventions, and presentations. With over 50 years of experience in e-learning, both in academic and corporate settings, he is known for his role in creating Authorware and overseeing the work of…

  11. Michael Eric Dyson: A Scholar and a Hip-Hop Preacher.

    ERIC Educational Resources Information Center

    Fletcher, Michael A.

    2000-01-01

    Introduces Michael Eric Dyson, an African American man who grew up in the ghetto and eventually received a PhD from Princeton University. Today, he is a professor at DePaul University, the author of a radically revisionist new biography of Martin Luther King, Jr., a lecturer and talk show guest, a Baptist preacher, and a self-styled hip-hop…

  12. Learning to Lose: Rurality, Transience, and Belonging (A Companion to Michael Corbett)

    ERIC Educational Resources Information Center

    Kelly, Ursula A.

    2009-01-01

    In this commentary, the author focuses on the central point of Michael Corbett's book "Learning to Leave". Education, and in particular what is called "rural" education, is premised on loss. This loss is often not fully articulated, but it is deep and abiding. It is registered in efforts to stop the flow of people and resources, to resist…

  13. Little Mosie from the Margaree: A Biography of Moses Michael Coady.

    ERIC Educational Resources Information Center

    Welton, Michael R.

    This book examines the life of the Reverend Moses Michael Coady (1890-1959), a Roman Catholic priest who led the Antigonish Movement. During the Antigonish Movement, residents of the small maritime town of Antigonish, Nova Scotia, worked to achieve a nonviolent alternative to communism and fascism and to effect the social and economic…

  14. Michael Faraday on the Learning of Science and Attitudes of Mind.

    ERIC Educational Resources Information Center

    Crawford, Elspeth

    1998-01-01

    Makes use of Michael Faraday's ideas on learning, focusing on his attitudes toward the unknowns of science and the development of an attitude that improves scientific decision making. This approach acknowledges that there is an inner struggle involved in facing unknowns. (DDR)

  15. Vision and Elusiveness in Philosophy of Education: R. S. Peters on the Legacy of Michael Oakeshott

    ERIC Educational Resources Information Center

    Williams, Kevin

    2009-01-01

    Despite his elusiveness on important issues, there is much in Michael Oakeshott's educational vision that Richard Peters quite rightly wishes to endorse. The main aim of this essay is, however, to consider Peters' justifiable critique of three features of Oakeshott's work. These are (1) the rigidity of his distinction between vocational and…

  16. 77 FR 41181 - CAlifornians for Renewable Energy, Inc., Michael E. Boyd, Robert M. Sarvey, v. Massachusetts...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-12

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission CAlifornians for Renewable Energy, Inc., Michael E. Boyd, Robert M. Sarvey, v. Massachusetts Department of Public Utilities, Massachusetts Electric Company, Nantucket Electric Company, Cape Wind Associates, LLC;...

  17. Schools as "Poetry-Friendly Places": Michael Rosen on Poetry in the Curriculum

    ERIC Educational Resources Information Center

    Xerri, Daniel

    2014-01-01

    This article explores the views of children's poet Michael Rosen in relation to poetry in education. It is based on an interview in which Rosen not only discusses the significance of encouraging young people to engage with poetry at school but also analyzes a number of threats to poetry's place in the English curriculum. This article…

  18. "Raising Standards" or Reducing Aspirations and Opportunities Still Further? Michael Gove and Examination Reforms

    ERIC Educational Resources Information Center

    Allen, Martin

    2013-01-01

    Well before the examinations grade crisis of 2012, Michael Gove had set out clear intentions for reforming public examinations. Though he claimed to be improving examinations and assessment by replicating practices that took place in high-performing countries and thus improving the ability of the UK economy to "compete", this…

  19. 78 FR 69661 - Michael Canales v. Edison International, EIX, Southern California Edison; Notice of Complaint

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-20

    ... shareholders and energy market manipulation by not adhering to the standards of the Uniform System of Accounts... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Michael Canales v. Edison International, EIX, Southern California...

  20. The Benevolent Technocrat: Michael Dukakis' Strategy in the 1988 Presidential Debates.

    ERIC Educational Resources Information Center

    Herbeck, Dale A.

    Michael Dukakis lost the presidential campaign debates of 1988 (or at least failed to capitalize as much as he might have) because he understood the debates to be genuine debates. Consequently, Dukakis acted as a debater generating an image of himself as a "benevolent technocrat," which was an error. It must be pointed out that the presidential…

  1. 76 FR 19420 - Michael J. Aruta, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-07

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF JUSTICE Drug Enforcement Administration Michael J. Aruta, M.D.; Decision and Order On August 10, 2010, Administrative Law Judge (ALJ) John J. Mulrooney, II, issued the attached recommended decision.\\1\\ The Respondent did not file exceptions to the decision....

  2. Irish Education for the 21st Century. Michael Enright Commemorative Project.

    ERIC Educational Resources Information Center

    Ward, Noel, Ed.; Dooney, Triona, Ed.

    The essays in this collection contribute to the ongoing discussion about the state of Irish education on the threshold of a new century. The various contributors examine issues that will be priorities for education planners in Ireland. These essays have been collected as a tribute to Irish educator and politician Michael Enright. The essays are:…

  3. Michael Pressley's Educational Legacy and Directions He Identified for Future Research in Reading Instruction

    ERIC Educational Resources Information Center

    Block, Cathy Collins

    2008-01-01

    The purpose of this article is to document the legacy and continuing influence of Michael Pressley's work in the field of reading research and instruction. Descriptions are provided to demonstrate how he translated his data from the cognitive sciences into highly effective pedagogy. A second component of this article discusses how Michael…

  4. Michael Duane after Risinghill: Rise and Fall of an Educational Celebrity

    ERIC Educational Resources Information Center

    Limond, David

    2005-01-01

    In this article an attempt is made to examine the continuing implications of the operation and closure of London's Risinghill school, a co-educational comprehensive extant from 1960 to 1965. It is suggested that Risinghill's controversial headteacher, Michael Duane (1915-1997), was an educational celebrity and folk hero amongst teachers and in…

  5. An Interview with Michael Horn: Blending Education for High-Octane Motivation

    ERIC Educational Resources Information Center

    Patterson, Gregory A.

    2012-01-01

    Blended learning holds the potential of improving the way we educate students and of making them more motivated. Blended education--the melding of information technology based distance learning with school attendance--is perhaps the best way to educate students for 21st century skills, says Michael Horn in a "Kappan" interview. Horn points out…

  6. A Tandem Michael-Aldol Reaction Sequence: An Undergraduate Research Organic Experiment.

    ERIC Educational Resources Information Center

    Coutlangus, Marilyn L.; And Others

    1989-01-01

    Presents a short reaction sequence that allows the student to determine by spectroscopic methods the constitution and stereochemistry of the reaction products. Reports the interpretations needed to illustrate the usefulness of the spectroscopic method. Notes the products of the Michael-Aldol reaction have not been reported in the literature. (MVL)

  7. A tribute to Michael R. Raupach for contributions to aeolian fluid dynamics

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Since the early work of Bagnold in the 1940s, aeolian research has grown to become a major integral part of earth-system studies. Many individuals have contributed to this development, and Dr. Michael R. Raupach (MR2, 1950 – 2015) was one of the most outstanding. MR2 worked for about a decade (1985 ...

  8. Michael Shaffer, 6th July 1936 to 23rd March 2009: A heartfelt tribute

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Mr. Michael Shaffer, Retired Pyraloidea Curator, at the Natural History Museum, London, England, passed away on March 23, 2009. He was an acknowledged world expert on Pyraloidea, a group of agriculturally important moths. He was curator of the largest Pyraloidea type collection in the world, and a...

  9. Michael Peters' Lyotardian Account of Postmodernism and Education: Some Epistemic Problems and Naturalistic Solutions

    ERIC Educational Resources Information Center

    Clark, John A.

    2006-01-01

    Postmodernism has established a significant hold in educational thought and some of the most important ideas are to be found in the writings of Michael Peters. This paper examines his postmodern stance and use of Lyotard's account of knowledge, and from a naturalist point of view raises a number of objections centred on science as a metanarrative,…

  10. 76 FR 21406 - Michael J. Aruta, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-15

    ... at 76 FR 19420 under the third column. Dated: April 8, 2011. Michele M. Leonhart, Administrator... Decision of the Administrative Law Judge (76 FR 19420). In preparing the document for publication, the... Enforcement Administration Michael J. Aruta, M.D.; Decision and Order ACTION: Correction. On Thursday, April...

  11. Broadening the Debate: Comments on Michael J. Feuer's "Moderating the Debate"

    ERIC Educational Resources Information Center

    Robertson, Emily

    2009-01-01

    In "Moderating the Debate: Rationality and the Promise of American Education", Michael Feuer argues that insights from cognitive science and the theory of bounded rationality can help us understand why educational policy makers overreach in seeking optimal solutions to educational problems. In this essay, Emily Robertson argues that cognitive…

  12. Michael-type reactions of tenulin, a biologically active sesquiterpene lactone.

    PubMed

    Waddell, T G; Gebert, P H; Tait, D L

    1983-12-01

    The antitumor pseudoguaianolide tenulin has been exposed to a wide variety of biological and model nucleophilic reagents and has been shown to react exclusively with sulfur nucleophiles in a Michael-like fashion. The biological implications of these results are discussed. PMID:6663489

  13. Humor and Film in the Geography Classroom: Learning from Michael Moore's "TV Nation"

    ERIC Educational Resources Information Center

    Alderman, Derek H.; Popke, E. Jeffrey

    2002-01-01

    How can teachers use humor and film to convert geography classrooms into public spaces for thinking and talking about the world in a critical way? One useful resource for raising student consciousness and critical discussion is "TV Nation"-a satirical television newsmagazine show created, produced, and hosted by rebel-filmmaker Michael Moore in…

  14. Why Do We Need a Philosophy of Education? The Forgotten Insights of Michael John Demiashkevich

    ERIC Educational Resources Information Center

    Senechal, Diana

    2010-01-01

    For many decades, American schools have been mired in jargon and confused values. A few exceptional books have shown the way through the thicket of educational ideas, policies, and practices. The work of Michael John Demiashkevich belongs to this set and offers a special philosophical perspective. In "An Introduction to the Philosophy of…

  15. What Work Do the Concepts of "Language" and "Literature" Do for Michael Rosenak?

    ERIC Educational Resources Information Center

    Levisohn, Jon A.

    2014-01-01

    Michael Rosenak uses the twin metaphors of "language" and "literature," borrowed from Oakeshott and Peters, to argue that the goal of education is initiation into a language. This goal transcends the study of literature in that language. It includes, as well, the development of the capacity both to critique literature and to…

  16. GENOTOXICITY IN MOUSE LYMPHOMA CELLS OF CHEMICAL CAPABLE OF MICHAEL ADDITION

    EPA Science Inventory

    Chemical agents that react via the Michael addition reaction have important industrial and consumer applications. ne of them, acrylamide, is used largely in the production of polymers as a flocculent in sewage and wastewater treatment, for coagulant treatment of potable water and...

  17. Subjectivity and Cultural Adjustment in Mathematics Education: A Response to Wolff-Michael Roth

    ERIC Educational Resources Information Center

    Brown, Tony

    2012-01-01

    In this volume, Wolff-Michael Roth provides a critical but partial reading of Tony Brown's book "Mathematics Education and Subjectivity". The reading contrasts Brown's approach with Roth's own conception of subjectivity as derived from the work of Vygotsky, in which Roth aims to "reunite" psychology and sociology. Brown's book, however, focuses on…

  18. Organocatalytic Enantioselective Intramolecular Oxa-Michael Reaction of Enols: Synthesis of Chiral Isochromenes.

    PubMed

    Parhi, Biswajit; Gurjar, Jitendra; Pramanik, Suman; Midya, Abhisek; Ghorai, Prasanta

    2016-06-01

    An unprecedented enantioselective intramolecular oxa-Michael reaction of enols has been described. A squaramide-containing tertiary amine based bifunctional organocatalyst efficiently activates the o-homoformyl chalcones to provide the chiral isochromenes in moderate yields and good to excellent enantioselectivities. Further, late-stage functionalizations of the vinyl ether moiety of the chiral isochromene products have also been exemplified. PMID:27176883

  19. Neuroscientific Investigator of High Mathematical Ability: An Interview with Michael W. O'Boyle

    ERIC Educational Resources Information Center

    Kalbfleisch, M. Layne

    2008-01-01

    This article presents an interview with Michael W. O'Boyle, a neuroscientific investigator of high mathematical ability. O'Boyle is a professor in the Department of Human Development and Family Studies, Texas Tech University, and Adjunct Professor of Pharmacology and Neuroscience, School of Medicine, Texas Tech University Health Sciences Center.…

  20. The power of virtual integration: an interview with Dell Computer's Michael Dell. Interview by Joan Magretta.

    PubMed

    Dell, M

    1998-01-01

    Michael Dell started his computer company in 1984 with a simple business insight. He could bypass the dealer channel through which personal computers were then being sold and sell directly to customers, building products to order. Dell's direct model eliminated the dealer's markup and the risks associated with carrying large inventories of finished goods. In this interview, Michael Dell provides a detailed description of how his company is pushing that business model one step further, toward what he calls virtual integration. Dell is using technology and information to blur the traditional boundaries in the value chain between suppliers, manufacturers, and customers. The individual pieces of Dell's strategy--customer focus, supplier partnerships, mass customization, just-in-time manufacturing--may be all be familiar. But Michael Dell's business insight into how to combine them is highly innovative. Direct relationships with customers create valuable information, which in turn allows the company to coordinate its entire value chain back through manufacturing to product design. Dell describes how his company has come to achieve this tight coordination without the "drag effect" of ownership. Dell reaps the advantages of being vertically integrated without incurring the costs, all the while achieving the focus, agility, and speed of a virtual organization. As envisioned by Michael Dell, virtual integration may well become a new organizational model for the information age. PMID:10177868

  1. A Response to Michael W. Apple's "Theory, Research, and the Critical Scholar/Activist"

    ERIC Educational Resources Information Center

    Leonardo, Zeus

    2010-01-01

    Michael Apple's prescient review of Anyon et al.'s "Theory and Educational Research" reminds the educational community of the importance of purpose. In his own work, he has been consistent in--actually, insistent on--emphasizing the struggle over political projects. This is not an issue concerning only the Left as the scapegoat for the disparaging…

  2. Q & A with Ed Tech Leaders: Interview with J. Michael Spector

    ERIC Educational Resources Information Center

    Shaughnessy, Michael F.; Fulgham, Susan M.

    2015-01-01

    J. Michael Spector's academic preparation was in philosophy--epistemology and logic, primarily. His dissertation was on skepticism in modern philosophy, and that led him to a deep-seated appreciation for classical skepticism. The word "skeptic" is derived from the Greek word "skepsis," which means investigation. While the…

  3. C. P. Snow's "The Two Cultures": Michael Polanyi's Response and Context

    ERIC Educational Resources Information Center

    Jacobs, Struan

    2011-01-01

    C. P. Snow's "The Two Cultures" controversially contrasted science and literature, suggesting that neither scientists nor literary intellectuals have much in common with, and seldom bother speaking to, the other. Responding to Snow, Michael Polanyi argued that specialization has made modern culture, not twofold but manifold. In his major work,…

  4. Michael E. Barnes: Award for Distinguished Professional Contributions to Institutional Practice

    ERIC Educational Resources Information Center

    American Psychologist, 2012

    2012-01-01

    Presents a short biography on the winner of the American Psychological Association's Award for Distinguished Professional Contributions to Institutional Practice. The 2012 winner is Michael E. Barnes for his pioneering leadership, dedication, and distinguished contributions to juvenile justice. As chief psychologist of the Superior Court of the…

  5. Design of Reversible, Cysteine-Targeted Michael Acceptors Guided by Kinetic and Computational Analysis

    PubMed Central

    2015-01-01

    Electrophilic probes that covalently modify a cysteine thiol often show enhanced pharmacological potency and selectivity. Although reversible Michael acceptors have been reported, the structural requirements for reversibility are poorly understood. Here, we report a novel class of acrylonitrile-based Michael acceptors, activated by aryl or heteroaryl electron-withdrawing groups. We demonstrate that thiol adducts of these acrylonitriles undergo β-elimination at rates that span more than 3 orders of magnitude. These rates correlate inversely with the computed proton affinity of the corresponding carbanions, enabling the intrinsic reversibility of the thiol-Michael reaction to be tuned in a predictable manner. We apply these principles to the design of new reversible covalent kinase inhibitors with improved properties. A cocrystal structure of one such inhibitor reveals specific noncovalent interactions between the 1,2,4-triazole activating group and the kinase. Our experimental and computational study enables the design of new Michael acceptors, expanding the palette of reversible, cysteine-targeted electrophiles. PMID:25153195

  6. The Journey Is the Film Is the Journey: Michael Winterbottom's "In This World"

    ERIC Educational Resources Information Center

    Farrier, David

    2008-01-01

    This essay examines Michael Winterbottom's 2002 film "In This World," which follows the journey of two Afghan migrants from Peshawar to London. Winterbottom's preparation involved travelling from London to Peshawar and then in reverse overland as far as Istanbul; he then returned to Peshawar and filmed the same journey using two non-professional…

  7. Astronaut C. Michael Foale is briefed on use of Sky Genie

    NASA Technical Reports Server (NTRS)

    1994-01-01

    Astronaut C. Michael Foale, STS-63 mission specialist, is briefed on the use of Sky Genie device by Karin L. Porter. The device would aid in emergency egress operations aboard a troubled Space Shuttle. Porter, an employee of Rockwell International, helps train astronauts in egress procedures at JSC's Shuttle mockup and integration laboratory.

  8. From Gouldner to Gramsci: The Making of Michael Apple's "Ideology and Curriculum"

    ERIC Educational Resources Information Center

    Gottesman, Isaac

    2012-01-01

    Michael Apple's "Ideology and Curriculum", published in 1979, helped initiate a broad turn in the field of education in the United States to Marxist thought as a lens through which to analyze the relationship between school and society. This classic text continues to inform scholarship in the field. While "Ideology" has received considerable…

  9. The Educational Philosophies of Mordecai Kaplan and Michael Rosenak: Surprising Similarities and Illuminating Differences

    ERIC Educational Resources Information Center

    Schein, Jeffrey; Caplan, Eric

    2014-01-01

    The thoughts of Mordecai Kaplan and Michael Rosenak present surprising commonalities as well as illuminating differences. Similarities include the perception that Judaism and Jewish education are in crisis, the belief that Jewish peoplehood must include commitment to meaningful content, the need for teachers to teach from a position of…

  10. Successful treatment of recalcitrant candidal intertrigo with Dr Michaels® (Fungatinex®) product family.

    PubMed

    Hercogovấ, J; Tirant, M; Bayer, P; Coburn, M; Donnelly, B; Kennedy, T; Gaibor, J; Arora, M; Clews, L; Fioranelli, M; Gianfaldoni, S; Chokoeva, A A; Tchernev, G; Wollina, U; Novotny, F; Roccia, M G; Maximov, G K; França, K; Lotti, T

    2016-01-01

    Candidal intertrigo is an infection of the skin caused by Candida albicans that typically occurs in opposing cutaneous or muco-cutaneous surfaces. Because Candidiasis requires a damaged and moist environment for infection, it typically occurs in areas of friction such as the skin folds of the body. Candidal intertrigo is often difficult to treat and results are often unsatisfactory. In addition, there is a lack of evidence-based literature supporting prevention and treatments for candidal intertrigo. The aim of the study was to evaluate the efficacy of Dr Michaels® (also branded as Fungatinex®) products in the treatment of fungal intertrigo, in 20 women and 2 men with a mean age of 72. Five patients (3 female and 2 male) had type 2 diabetes and 16 (14 female and 2 male) were obese. The patients were treated with Dr Michaels® (Fungatinex®) moisturising bar, topical ointment (twice daily application) and oral herbal formulation, PSC 200 two tablets twice daily with food. After 2 weeks of treatment, the lesions had mostly resolved in all patients with only slight erythema evident. After six weeks of treatment using the moisturising bar, topical ointment and oral herbal formulations from the Dr Michaels® (Fungatinex®) product family, the lesions had totally resolved in 18 patients, while 4 patients had to continue the therapeutic protocol for another 2 weeks. Our results demonstrate that the Dr Michaels® (Fungatinex®) complementary product family is efficacious in the treatment of recalcitrant candidal intertrigo. Furthermore, this study highlights that the Dr Michaels® (Fungatinex®) product family is fast-acting and well tolerated with no serious adverse events reported. These data have important implications for resistant cases of candidal intertrigo where traditional therapies have failed. PMID:27498664

  11. A DATABASE FOR TRACKING TOXICOGENOMIC SAMPLES AND PROCEDURES WITH GENOMIC, PROTEOMIC AND METABONOMIC COMPONENTS

    EPA Science Inventory

    A Database for Tracking Toxicogenomic Samples and Procedures with Genomic, Proteomic and Metabonomic Components
    Wenjun Bao1, Jennifer Fostel2, Michael D. Waters2, B. Alex Merrick2, Drew Ekman3, Mitchell Kostich4, Judith Schmid1, David Dix1
    Office of Research and Developmen...

  12. Landsat-4 horizon scanner flight performance

    NASA Technical Reports Server (NTRS)

    Bilanow, S.; Chen, L. C.

    1984-01-01

    This paper presents an analysis of the flight data from a new design of horizon scanner flown on Landsat-4. The salient features in the data are described and demonstrated by data plots. High frequency noise must be filtered out to achieve good accuracy, but this is effectively done by 128-point averaging. Sun and moon interference effects are identified. The effects of earth oblateness and spacecraft altitude variations are modeled, and the residual systematic errors are analyzed. Most of the residual errors are apparently explained by the effects of earth radiance variation, with the winter polar regions showing the highest variability in the attitude measurements due to winter stratosphere temperature variations. In general, this sensor provides improved accuracy over those flown on previous missions.

  13. Black Hole Observations - Towards the Event Horizon

    NASA Astrophysics Data System (ADS)

    Britzen, Silke

    Black Holes are probably the most elusive solutions of Einstein's theory of General Relativity. Despite numerous observations of the direct galactic environment and indirect influence of astrophysical black holes (e.g. jets, variable emission across the wavelength spectrum, feedback processes, etc.) -- a direct proof of their existence is still lacking. This article highlights some aspects deduced from many observations and concentrates on the experimental results with regard to black holes with masses from millions to billions of solar masses. The focus will be on the challenges and remaining questions. The Event Horizon Telescopce (EHT) project to image the photon sphere of Sgr A* and its potential is briefly sketched. This instrumental approach shall lead to highest resolution observations of the supermassive black hole at the center of the Milky Way (Sgr A*).

  14. Horizon complementarity in elliptic de Sitter space

    NASA Astrophysics Data System (ADS)

    Hackl, Lucas; Neiman, Yasha

    2015-02-01

    We study a quantum field in elliptic de Sitter space dS4/Z2—the spacetime obtained from identifying antipodal points in dS4. We find that the operator algebra and Hilbert space cannot be defined for the entire space, but only for observable causal patches. This makes the system into an explicit realization of the horizon complementarity principle. In the absence of a global quantum theory, we propose a recipe for translating operators and states between observers. This translation involves information loss, in accordance with the fact that two observers see different patches of the spacetime. As a check, we recover the thermal state at the de Sitter temperature as a state that appears the same to all observers. This thermal state arises from the same functional that, in ordinary dS4, describes the Bunch-Davies vacuum.

  15. Opportunity Spies 'Endurance' on the Horizon

    NASA Technical Reports Server (NTRS)

    2004-01-01

    This image taken by the Mars Exploration Rover Opportunity's panoramic camera shows the eastern plains that stretch beyond the small crater where the rover landed. In the distance, the rim of a larger crater dubbed 'Endurance' can be seen.

    This color mosaic was taken on the 32nd martian day, or sol, of the rover's mission and spans 20 degrees of the horizon. It was taken while Opportunity was parked at the north end of the outcrop, in front of the rock region dubbed 'El Capitan' and facing east.

    The features seen at the horizon are the near and far rims of 'Endurance,' the largest crater within about 6 kilometers (4 miles) of the lander. Using orbital data from the Mars Orbiter Camera on NASA's Mars Global Surveyor spacecraft, scientists estimated the crater to be 160 meters (175 yards) in diameter, and about 720 meters (half a mile) away from the lander.

    The highest point visible on 'Endurance' is the highest point on the far wall of the crater; the sun is illuminating the inside of the far wall.

    Between the location where the image was taken at 'El Capitan' and 'Endurance' are the flat, smooth Meridiani plains, which scientists believe are blanketed in the iron-bearing mineral called hematite. The dark horizontal feature near the bottom of the picture is a small, five-meter (16-feet) crater, only 50 meters (164 feet) from Opportunity's present position. When the rover leaves the crater some 2 to 3 weeks from now, 'Endurance' is one of several potential destinations.

  16. Air-shower spectroscopy at horizons

    NASA Astrophysics Data System (ADS)

    Fargion, D.

    2006-07-01

    Downward cosmic rays are mostly revealed on the ground by their air-showers diluted and filtered secondary μμ traces and/or by their (Cerenkov - Fluorescent) light because of the high altitude numerous and luminous electromagnetic ee,γ shower component. Horizontal and upward air-showers are even more suppressed by deeper atmosphere opacity and by the Earth shadows. In such noise-free horizontal and upward directions rare Ultra High Cosmic rays and rarer neutrino induced air-showers may shine, mostly mediated by resonant PeV ν¯+e→W interactions in air or by higher energy tau air-showers originated by ν skimming the Earth. At high altitude (mountains, planes, balloons) the air density is so rarefied that nearly all common air-showers might be observed at their maximal growth at a tuned altitude and direction. The arrival angle samples different distances and the corresponding most probable primary cosmic ray energy. The larger and larger distances (between observer and C.R. interaction) make wider and wider the shower area and it enlarges the probability of being observed (up to three orders of magnitude more than vertical showers); the observation of a maximal electromagnetic shower development may amplify the signal by two three orders of magnitude (with respect to a suppressed shower at sea level); the peculiar altitude angle range (ten twenty km height and ≃80 90 zenith angle) may disentangle at best the primary cosmic ray energy and composition. Even from existing mountain observatories the up-going air-showers may trace, above the horizons, PeV EeV high energy cosmic rays and, below the horizons, PeV EeV neutrino astronomy: their early signals may be captured in already existing gamma telescopes such as Magic at Canarie, while facing the Earth edges during (useless) cloudy nights.

  17. THERMAL CONDUCTIVITY OF THE POTENTIAL REPOSITORY HORIZON

    SciTech Connect

    J.E. BEAN

    2004-09-27

    The primary purpose of this report is to assess the spatial variability and uncertainty of bulk thermal conductivity in the host horizon for the repository at Yucca Mountain. More specifically, the lithostratigraphic units studied are located within the Topopah Spring Tuff (Tpt) and consist of the upper lithophysal zone (Tptpul), the middle nonlithophysal zone (Tptpmn), the lower lithophysal zone (Tptpll), and the lower nonlithophysal zone (Tptpln). Design plans indicate that approximately 81 percent of the repository will be excavated in the Tptpll, approximately 12 percent in the Tptpmn, and the remainder in the Tptul and Tptpln (BSC 2004 [DIRS 168370]). This report provides three-dimensional geostatistical estimates of the bulk thermal conductivity for the four stratigraphic layers of the repository horizon. The three-dimensional geostatistical estimates of matrix and lithophysal porosity, dry bulk density, and matrix thermal conductivity are also provided. This report provides input to various models and calculations that simulate heat transport through the rock mass. These models include the ''Drift Degradation Analysis, Multiscale Thermohydrologic Model, Ventilation Model and Analysis Report, Igneous Intrusion Impacts on Waste Packages and Waste Forms, Drift-Scale Coupled Processes (DST and TH Seepage) Models'', and ''Drift Scale THM Model''. These models directly or indirectly provide input to the total system performance assessment (TSPA). The main distinguishing characteristic among the lithophysal and nonlithophysal units is the percentage of large-scale (centimeters-meters) voids within the rock. The Tptpul and Tptpll, as their names suggest, have a higher percentage of lithophysae than the Tptpmn and the Tptpln. Understanding the influence of the lithophysae is of great importance to understanding bulk thermal conductivity.

  18. New Horizons Risk Communication Strategy, Planning, Implementation, and Lessons Learned

    NASA Technical Reports Server (NTRS)

    Dawson, Sandra A.

    2006-01-01

    This paper discusses the risk communication goals, strategy, planning process and product development for the New Horizons mission, including lessons from the Cassini mission that were applied in that effort, and presents lessons learned from the New Horizons effort that could be applicable to future missions.

  19. The Horizon Report: 2010 Australia-New Zealand Edition

    ERIC Educational Resources Information Center

    Johnson, L.; Smith, R.; Levine, A.; Haywood, K.

    2010-01-01

    The internationally recognized series of "Horizon Reports" is part of the New Media Consortium's Horizon Project, a comprehensive research venture established in 2002 that identifies and describes emerging technologies likely to have a large impact over the coming five years on a variety of sectors around the globe. This volume, the "2010 Horizon…

  20. The NMC Horizon Report: 2013 Higher Education Edition

    ERIC Educational Resources Information Center

    Johnson, L.; Adams Becker, S.; Cummins, M.; Estrada, V.; Freeman, A.; Ludgate, H.

    2013-01-01

    The internationally recognized "NMC Horizon Report" series and regional "NMC Technology Outlooks" are part of the NMC Horizon Project, a comprehensive research venture established in 2002 that identifies and describes emerging technologies likely to have a large impact over the coming five years in education around the globe.…

  1. The Horizon Report: 2009 Australia-New Zealand Edition

    ERIC Educational Resources Information Center

    Johnson, L.; Levine, A.; Smith, R.; Smythe, T.; Stone, S.

    2009-01-01

    The New Media Consortium's Horizon Project is an ongoing research project that aims to identify and describe emerging technologies likely to have a large impact on teaching, learning, or creative inquiry within education around the globe over a five-year time period. The project's central products are the "Horizon Reports", an annual series of…

  2. The NMC Horizon Report: 2013 K-12 Edition

    ERIC Educational Resources Information Center

    Johnson, L.; Adams Becker, S.; Cummins, M.; Estrada V.; Freeman, A.; Ludgate, H.

    2013-01-01

    "The NMC Horizon Report" series is the most visible outcome of the New Media Consortium (NMC) Horizon Project, an ongoing research effort established in 2002 that identifies and describes emerging technologies likely to have a large impact on teaching, learning, research, or creative expression within education around the globe. This…

  3. The NMC Horizon Report: 2012 Higher Education Edition

    ERIC Educational Resources Information Center

    Johnson, L.; Adams, S.; Cummins, M.

    2012-01-01

    The internationally recognized "NMC Horizon Report" series and regional "NMC Technology Outlooks" are part of the NMC Horizon Project, a comprehensive research venture established in 2002 that identifies and describes emerging technologies likely to have a large impact over the coming five years in education around the globe. This volume, the "NMC…

  4. A Fusion of Horizons: Students' Encounters with "Will and Wave"

    ERIC Educational Resources Information Center

    Myers, James L.

    2006-01-01

    In a case study, I applied philosophical hermeneutic principles in an advanced level EFL writing class in Taiwan. A "fusion of horizons" occurs at the junction of two intertwined interpretations: one from our socio-historical tradition and the other from our experience of novel phenomena. I explored students' hermeneutic horizons in relation to…

  5. The NMC Horizon Report: 2011 K-12 Edition

    ERIC Educational Resources Information Center

    Johnson, L.; Adams, S.; Haywood, K.

    2011-01-01

    "The NMC Horizon Report" series is the most visible outcome of the New Media Consortium. (NMC) Horizon Project, an ongoing research effort established in 2002 that identifies and describes emerging technologies likely to have a large impact on teaching, learning, research, or creative expression within education around the globe. This volume, "The…

  6. NEW JERSEY APPROACH TO OUTERBRIDGE CROSSING BRIDGE, NOTE DISTANT HORIZON ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    NEW JERSEY APPROACH TO OUTERBRIDGE CROSSING BRIDGE, NOTE DISTANT HORIZON NEW YORK SKYLINE AND ALMOST IN THE MIDDLE OF THE HORIZON THE TWIN TOWERS OF THE VERRAZANO-NARROWS BRIDGE - Outerbridge Crossing Bridge, Spanning Arthur Kill from New Jersey to Staten Island, Staten Island (subdivision), Richmond County, NY

  7. The NMC Horizon Report: 2015 Higher Education Edition

    ERIC Educational Resources Information Center

    Johnson, L.; Adams Becker, S.; Estrada, V.; Freeman, A.

    2015-01-01

    The "NMC Horizon Report: 2015 Higher Education Edition" is a collaborative effort between the New Media Consortium (NMC) and the EDUCAUSE Learning Initiative (ELI). This 12th edition describes annual findings from the NMC Horizon Project, an ongoing research project designed to identify and describe emerging technologies likely to have…

  8. The NMC Horizon Report: 2014 K-12 Edition

    ERIC Educational Resources Information Center

    Johnson, L.; Adams Becker, S.; Estrada, V.; Freeman, A.

    2014-01-01

    "The NMC Horizon Report" series is the most visible outcome of the New Media Consortium (NMC) Horizon Project, an ongoing research effort established in 2002 that identifies and describes emerging technologies likely to have a large impact on teaching, learning, research, or creative expression within every sector of education in some 65…

  9. Fluctuations in horizon-fluid lead to negative bulk viscosity

    NASA Astrophysics Data System (ADS)

    Bhattacharya, Swastik; Shankaranarayanan, S.

    2016-03-01

    Einstein equations projected on to a black-hole horizon give rise to Navier-Stokes equations. Horizon-fluids typically possess unusual features like negative bulk viscosity, and it is not clear whether a statistical-mechanical description exists for such fluids. In this work, we provide an explicit derivation of the Bulk viscosity of the horizon-fluid based on the theory of fluctuations à la Kubo. The main advantage of our approach is that our analysis remains for the most part independent of the details of the underlying microscopic theory and hence the conclusions reached here are model independent. We show that the coefficient of bulk viscosity for the horizon-fluid matches exactly with the value found from the equations of motion for the horizon-fluid.

  10. Observations of the Geometry of Horizon-Based Optical Navigation

    NASA Technical Reports Server (NTRS)

    Christian, John; Robinson, Shane

    2016-01-01

    NASA's Orion Project has sparked a renewed interest in horizon-based optical navigation(OPNAV) techniques for spacecraft in the Earth-Moon system. Some approaches have begun to explore the geometry of horizon-based OPNAV and exploit the fact that it is a conic section problem. Therefore, the present paper focuses more deeply on understanding and leveraging the various geometric interpretations of horizon-based OPNAV. These results provide valuable insight into the fundamental workings of OPNAV solution methods, their convergence properties, and associated estimate covariance. Most importantly, the geometry and transformations uncovered in this paper lead to a simple and non-iterative solution to the generic horizon-based OPNAV problem. This represents a significant theoretical advancement over existing methods. Thus, we find that a clear understanding of geometric relationships is central to the prudent design, use, and operation of horizon-based OPNAV techniques.

  11. 76 FR 55427 - Horizon Technology Finance Corporation, et al.; Notice of Application

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-07

    ... COMMISSION Horizon Technology Finance Corporation, et al.; Notice of Application August 31, 2011. AGENCY...(a) of the Act. Applicants: Horizon Technology Finance Corporation (the ``Company''), Horizon Technology Finance Management LLC (the ``Investment Adviser''), Longview SBIC GP LLC (the ``General...

  12. Horizon shells and BMS-like soldering transformations

    NASA Astrophysics Data System (ADS)

    Blau, Matthias; O'Loughlin, Martin

    2016-03-01

    We revisit the theory of null shells in general relativity, with a particular emphasis on null shells placed at horizons of black holes. We study in detail the considerable freedom that is available in the case that one solders two metrics together across null hypersurfaces (such as Killing horizons) for which the induced metric is invariant under translations along the null generators. In this case the group of soldering transformations turns out to be infinite dimensional, and these solderings create non-trivial horizon shells containing both massless matter and impulsive gravitational wave components. We also rephrase this result in the language of Carrollian symmetry groups. To illustrate this phenomenon we discuss in detail the example of shells on the horizon of the Schwarzschild black hole (with equal interior and exterior mass), uncovering a rich classical structure at the horizon and deriving an explicit expression for the general horizon shell energy-momentum tensor. In the special case of BMS-like soldering supertranslations we find a conserved shell-energy that is strikingly similar to the standard expression for asymptotic BMS supertranslation charges, suggesting a direct relation between the physical properties of these horizon shells and the recently proposed BMS supertranslation hair of a black hole.

  13. Physical process first law for bifurcate Killing horizons

    SciTech Connect

    Amsel, Aaron J.; Marolf, Donald; Virmani, Amitabh

    2008-01-15

    The physical process version of the first law for black holes states that the passage of energy and angular momentum through the horizon results in a change in area ({kappa}/8{pi}){delta}A={delta}E-{omega}{delta}J, so long as this passage is quasistationary. A similar physical process first law can be derived for any bifurcate Killing horizon in any spacetime dimension d{>=}3 using much the same argument. However, to make this law nontrivial, one must show that sufficiently quasistationary processes do in fact occur. In particular, one must show that processes exist for which the shear and expansion remain small, and in which no new generators are added to the horizon. Thorne, MacDonald, and Price considered related issues when an object falls across a d=4 black hole horizon. By generalizing their argument to arbitrary d{>=}3 and to any bifurcate Killing horizon, we derive a condition under which these effects are controlled and the first law applies. In particular, by providing a nontrivial first law for Rindler horizons, our work completes the parallel between the mechanics of such horizons and those of black holes for d{>=}3. We also comment on the situation for d=2.

  14. Direct asymmetric vinylogous Michael addition of cyclic enones to nitroalkenes via dienamine catalysis

    PubMed Central

    Bencivenni, Giorgio; Galzerano, Patrizia; Mazzanti, Andrea; Bartoli, Giuseppe; Melchiorre, Paolo

    2010-01-01

    In spite of the many catalytic methodologies available for the asymmetric functionalization of carbonyl compounds at their α and β positions, little progress has been achieved in the enantioselective carbon–carbon bond formation γ to a carbonyl group. Here, we show that primary amine catalysis provides an efficient way to address this synthetic issue, promoting vinylogous nucleophilicity upon selective activation of unmodified cyclic α,β-unsaturated ketones. Specifically, we document the development of the unprecedented direct and vinylogous Michael addition of β-substituted cyclohexenone derivatives to nitroalkenes proceeding under dienamine catalysis. Besides enforcing high levels of diastereo- and enantioselectivity, chiral primary amine catalysts derived from natural cinchona alkaloids ensure complete γ-site selectivity: The resulting, highly functionalized vinylogous Michael adducts, having two stereocenters at the γ and δ positions, are synthesized with very high fidelity. Finally, we describe the extension of the dienamine catalysis-induced vinylogous nucleophilicity to the asymmetric γ-amination of cyclohexene carbaldehyde. PMID:20566884

  15. Direct asymmetric vinylogous Michael addition of cyclic enones to nitroalkenes via dienamine catalysis.

    PubMed

    Bencivenni, Giorgio; Galzerano, Patrizia; Mazzanti, Andrea; Bartoli, Giuseppe; Melchiorre, Paolo

    2010-11-30

    In spite of the many catalytic methodologies available for the asymmetric functionalization of carbonyl compounds at their α and β positions, little progress has been achieved in the enantioselective carbon-carbon bond formation γ to a carbonyl group. Here, we show that primary amine catalysis provides an efficient way to address this synthetic issue, promoting vinylogous nucleophilicity upon selective activation of unmodified cyclic α,β-unsaturated ketones. Specifically, we document the development of the unprecedented direct and vinylogous Michael addition of β-substituted cyclohexenone derivatives to nitroalkenes proceeding under dienamine catalysis. Besides enforcing high levels of diastereo- and enantioselectivity, chiral primary amine catalysts derived from natural cinchona alkaloids ensure complete γ-site selectivity: The resulting, highly functionalized vinylogous Michael adducts, having two stereocenters at the γ and δ positions, are synthesized with very high fidelity. Finally, we describe the extension of the dienamine catalysis-induced vinylogous nucleophilicity to the asymmetric γ-amination of cyclohexene carbaldehyde. PMID:20566884

  16. Methylthiodeoxynivalenol (MTD): insight into the chemistry, structure and toxicity of thia-Michael adducts of trichothecenes.

    PubMed

    Fruhmann, Philipp; Weigl-Pollack, Theresa; Mikula, Hannes; Wiesenberger, Gerlinde; Adam, Gerhard; Varga, Elisabeth; Berthiller, Franz; Krska, Rudolf; Hametner, Christian; Fröhlich, Johannes

    2014-07-28

    Methylthiodeoxynivalenol (MTD), a novel derivative of the trichothecene mycotoxin deoxynivalenol (DON), was prepared by applying a reliable procedure for the formal Michael addition of methanethiol to the conjugated double bond of DON. Structure elucidation revealed the preferred formation of the hemiketal form of MTD by intramolecular cyclisation between C8 and C15. Computational investigations showed a negative total reaction energy for the hemiketalisation step and its decrease in comparison with theoretical model compounds. Therefore, this structural behaviour seems to be a general characteristic of thia-Michael adducts of type B trichothecenes. MTD was shown to be less inhibitory for a reticulocyte lysate based in vitro translation system than the parent compound DON, which supports the hypothesis that trichothecenes are detoxified through thia-adduct formation during xenobiotic metabolism. PMID:24903010

  17. Bifunctional Chiral Dehydroalanines for Peptide Coupling and Stereoselective S-Michael Addition.

    PubMed

    Gutiérrez-Jiménez, Marta I; Aydillo, Carlos; Navo, Claudio D; Avenoza, Alberto; Corzana, Francisco; Jiménez-Osés, Gonzalo; Zurbano, María M; Busto, Jesús H; Peregrina, Jesús M

    2016-06-17

    A second generation of chiral bicyclic dehydroalanines easily accessible from serine has been developed. These scaffolds behaved as excellent S-Michael acceptors when tri-O-acetyl-2-acetamido-2-deoxy-1-thio-α-d-galactopyranose (abbreviated as GalNAc-α-SH) was used as a nucleophile. This addition proceeds with total chemo- and stereoselectivity, complete atom economy, quickly, and at room temperature, making it a true click reaction. The Michael adducts were easily transformed into S-(2-acetamido-2-deoxy-α-d-galactopyranosyl)-l- and -d-cysteines, which can be regarded as mimics of the Tn antigen derived from l-Ser (α-d-GalNAc-l-Ser) and d-Ser (α-d-GalNAc-d-Ser), respectively. PMID:27246362

  18. [An exceptional human relationship (Michael P. Kierkegaard, Søren Kierkegaard)].

    PubMed

    Jacobs, R

    1978-01-01

    There were a father and a son, Michael and Sören Kierkegaard, both highly talented, imaginitive, witty, humorous, especially interested in shrewd dialectrical dialogues respectively debates, both profound melancholy ponderers. But according to very own individuality their congeniality wasn't absolute. The father, being under a questionable rigorous opinion of sin, suffered from undeserved divine grace since early childhood. And Michael Kierkegaard made Sören anxious with the religious experience of original sin. This anxiety moved (touched or affected) the sensitive son mighty. Nevertheless he should not despair hopelessly like his unlucky father. On the contrary: Sørens incomparable melancholy, mental agony and anxiety (fear or anguish) forced the faith, existing independently of them, in a radical refining. That is why Sören Kierkegaard succeeded in sublimation of all psychological and philosophic (al) attitudes (or opinions) in the sphere of religiousness. And the result? A novel philosophy of life: Christian existentialism. PMID:364877

  19. Possible New Horizons Fundamental Contribution to Cosmology

    NASA Astrophysics Data System (ADS)

    Conn Henry, Richard; Murthy, Jayant

    2016-01-01

    The New Horizons (NH) spacecraft (S. Alan Stern, PI) is now past Pluto, and in our poster we explore the possibility of making observations, using the NH P-Alice ultraviolet spectrometer, of the cosmic diffuse ultraviolet background radiation, particularily at high northern and southern Galactic latitudes. In the paper, "The Mystery of the Cosmic Diffuse Ultraviolet Background Radiation," by Richard Conn Henry, Jayant Murthy, James Overduin, Joshua Tyler, ApJ, 798:14 (25pp), 2015 January 1, we demonstrated the existence of a second component of the diffuse far ultraviolet background radiation beyond that provided by dust-scattered starlight. The critical question is, does that second component (of unknown origin) extend shortward of the Lyman limit of 912 Å? If it does, then it seems likely that we have discovered the source of the reionization of the Universe that occurred some time after recombination. As things stand at the moment, there is no known source that has been demonstrated to be capable of performing the reionization: reionization that clearly did occur. Our current understanding of P-Alice suggests that it may well be capable of demonstrating the presence (or absence) of such ionizing cosmic diffuse radiation. At low Galactic latitudes, all such radiation would be totally erased by the presence, in large quantities, of interstellar neutral hydrogen; this will allow us to test the reality of any such flux that we may discover at higher Galactic latitudes.

  20. Lunar horizon glow and the Clementine mission

    NASA Technical Reports Server (NTRS)

    Zook, H. A.; Potter, A. E.

    1994-01-01

    The Clementine spacecraft is to be launched into Earth orbit in late January for subsequent insertion into lunar orbit in late February, 1994. There, its primary mission is to produce -- over a period of about two months -- a new photographic map of the entire surface of the Moon; this will be done, in a variety of wavelengths and spatial resolutions, in a manner greatly superior to that previously accomplished for the whole Moon. It will then go on to fly by and photograph the asteroid Geographos. A secondary goal that has been accepted for this mission is to take a series of photographs designed to capture images of, and determine the brightness and extent of, the Lunar Horizon Glow (LHG). One form of LHG is caused by the solar stimulation of emission from Na and K atoms in the lunar exosphere. The scale height of this exosphere is of the order of 100 km. There are also brighter LHG components, with much smaller scale heights, that appear to be caused by scattered off of an exospheric lunar dust cloud.

  1. Perturbative string thermodynamics near black hole horizons

    NASA Astrophysics Data System (ADS)

    Mertens, Thomas G.; Verschelde, Henri; Zakharov, Valentin I.

    2015-06-01

    We provide further computations and ideas to the problem of near-Hagedorn string thermodynamics near (uncharged) black hole horizons, building upon our earlier work [1]. The relevance of long strings to one-loop black hole thermodynamics is emphasized. We then provide an argument in favor of the absence of α'-corrections for the (quadratic) heterotic thermal scalar action in Rindler space. We also compute the large k limit of the cigar orbifold partition functions (for both bosonic and type II superstrings) which allows a better comparison between the flat cones and the cigar cones. A discussion is made on the general McClain-Roth-O'Brien-Tan theorem and on the fact that different torus embeddings lead to different aspects of string thermodynamics. The black hole/string correspondence principle for the 2d black hole is discussed in terms of the thermal scalar. Finally, we present an argument to deal with arbitrary higher genus partition functions, suggesting the breakdown of string perturbation theory (in g s ) to compute thermodynam-ical quantities in black hole spacetimes.

  2. Large Dust Devil on Horizon, Sol 468

    NASA Technical Reports Server (NTRS)

    2005-01-01

    This movie clip shows a large, distant dust devil -- a whirlwind that lofts dust into the air -- as a dark shape on the horizon near the right side of the images. This dust devil was about 5 kilometers (3 miles) away from NASA's Mars Exploration Rover Spirit, and may have been up to 200 meters or yards in diameter. Smaller dust devils closer to the rover appear bright against the dark ground. Spirit's navigation camera took these images on the rover's 468th martian day, or sol (April 27, 2005.) Contrast has been enhanced for anything in the images that changes from frame to frame, that is, for the dust devil. The number of seconds elapsed since the first frame is indicated at lower left of the images, typically 20 seconds between frames.

    Scientists expected dust devils since before Spirit landed. The landing area inside Gusev Crater is filled with dark streaks left behind when dust devils pick dust up from an area. It is also filled with bright 'hollows,' which are dust-filled miniature craters. Dust covers most of the terrain. Winds flow into and out of Gusev crater every day. The Sun heats the surface so that the surface is warm to the touch even though the atmosphere at 2 meters (6 feet) above the surface would be chilly. That temperature contrast causes convection. Mixing the dust, winds, and convection can trigger dust devils.

  3. LANDSAT-4 horizon scanner performance evaluation

    NASA Technical Reports Server (NTRS)

    Bilanow, S.; Chen, L. C.; Davis, W. M.; Stanley, J. P.

    1984-01-01

    Representative data spans covering a little more than a year since the LANDSAT-4 launch were analyzed to evaluate the flight performance of the satellite's horizon scanner. High frequency noise was filtered out by 128-point averaging. The effects of Earth oblateness and spacecraft altitude variations are modeled, and residual systematic errors are analyzed. A model for the predicted radiance effects is compared with the flight data and deficiencies in the radiance effects modeling are noted. Correction coefficients are provided for a finite Fourier series representation of the systematic errors in the data. Analysis of the seasonal dependence of the coefficients indicates the effects of some early mission problems with the reference attitudes which were computed by the onboard computer using star trackers and gyro data. The effects of sun and moon interference, unexplained anomalies in the data, and sensor noise characteristics and their power spectrum are described. The variability of full orbit data averages is shown. Plots of the sensor data for all the available data spans are included.

  4. Development of novel 1,4-benzodiazepine-based Michael acceptors as antitrypanosomal agents.

    PubMed

    Ettari, Roberta; Previti, Santo; Cosconati, Sandro; Maiorana, Santina; Schirmeister, Tanja; Grasso, Silvana; Zappalà, Maria

    2016-08-01

    Novel 1,4-benzodiazepines, endowed with a Michael acceptor moiety, were designed taking advantage of a computational prediction of their pharmacokinetic parameters. Among all the synthesized derivatives, we identified a new lead compound (i.e., 4a), bearing a vinyl ketone warhead and endowed with a promising antitrypanosomal activity against Trypanosoma brucei brucei (IC50=5.29μM), coupled with a lack of cytotoxicity towards mammalian cells (TC50 >100μM). PMID:27372809

  5. Organocatalytic Michael addition of 1,3-dicarbonyl indane compounds to nitrostyrenes.

    PubMed

    Jiang, Zhen-Yu; Yang, Hua-Meng; Ju, Ya-Dong; Li, Li; Luo, Meng-Xian; Lai, Guo-Qiao; Jiang, Jian-Xiong; Xu, Li-Wen

    2010-04-01

    To map out the efficient organocatalyst requirements in the Michael addition of 1,3-dicarbonyl indane compounds to nitrostyrenes, a dozen different amino organocatalysts containing a p-toluenesulfonyl group (Ts) have been evaluated; excellent enantio-selectivities (up to er 92:8) were obtained with a primary amine-based Ts-DPEN catalyst and a plausible catalytic reaction mechanism was proposed on the basis of the experimental results. PMID:20428063

  6. Synthesis of Oxazolidin-4-ones: Domino O-Alkylation/Aza-Michael/Intramolecular Retro-Claisen Condensation.

    PubMed

    El Bouakher, Abderrahman; Le Goff, Ronan; Tasserie, Jordan; Lhoste, Jérôme; Martel, Arnaud; Comesse, Sébastien

    2016-05-20

    An original and rapid domino reaction for access to oxazolidin-4-ones is presented. Simply by heating α-bromoamido alcohol in the presence of KNaCO3 and water with readily prepared Michael acceptors, an unprecedented molecular rearrangement is generated. This new methodology enables the hitherto unreported synthesis of functionalized oxazolidin-4-ones. The process was proved to be compatible with a wide variety of substrates, and high regioselectivities were achieved. PMID:27128809

  7. Michael's Marathon: My Experience of Overcoming Illiteracy as an Adult. Literacy Lessons.

    ERIC Educational Resources Information Center

    Marquet, Michael

    Michael Marquet of New Zealand left school 10 years ago, not able to read or write and with a serious speech problem. He had spent 9 years in a special class and had learned very little. He had completed 2 years of high school and left at the end of the fourth form, at the age of 15 and with no qualifications. However, he had participated in a…

  8. L-Proline Derived Bifunctional Organocatalysts: Enantioselective Michael Addition of Dithiomalonates to trans-β-Nitroolefins.

    PubMed

    Jin, Hui; Kim, Seung Tae; Hwang, Geum-Sook; Ryu, Do Hyun

    2016-04-15

    A series of novel L-proline derived tertiary amine bifunctional organocatalysts 9 are reported, which were applied to the asymmetric Michael addition of dithiomalonates 2 to trans-β-nitroolefins 1. The reaction proceeded in high yields (up to 99%) with high enantioselectivities (up to 97% ee). The synthetic utility of this methodology was demonstrated in the short synthesis of (R)-phenibut in high yield. PMID:26989804

  9. STS-113 Mission Specialist Michael Lopez-Alegria looks over the P1 Truss

    NASA Technical Reports Server (NTRS)

    2002-01-01

    KENNEDY SPACE CENTER, FLA. -- STS-113 Mission Specialist Michael Lopez-Alegria looks over the P1 Integrated Truss Structure, the primary payload for the mission. The P1 truss will be attached to the central truss segment, S0 Truss, during spacewalks. The payload also includes the Crew and Equipment Translation Aid (CETA) Cart B that can be used by spacewalkers to move along the truss with equipment. STS-113 is scheduled to launch Oct. 6, 2002.

  10. Synthetic protocol toward fused pyrazolone derivatives via a Michael addition and reductive ring closing strategy.

    PubMed

    Parekh, Nikita; Thomas, Joice; John, Jubi; Kusurkar, Radhika; De Borggraeve, Wim M; Dehaen, Wim

    2014-06-01

    A new class of pyrazolo[3,4-c]pyridine-3,7-dione and pyrazolo[3,4-d]azepine-3,7-dione scaffolds was synthesized via a Michael addition and reductive cyclization strategy. These fused heterocycles were accessed from simple starting materials such as nitroolefins and 3-ethoxycarbonyl(methylene)pyrazoline-5-one. The pyrazolo-fused heterocycles were obtained in good overall yields. PMID:24797239

  11. Highlighting High Performance: Michael E. Capuano Early Childhood Center; Somerville, Massachusetts

    SciTech Connect

    Not Available

    2006-03-01

    This brochure describes the key high-performance building features of the Michael E. Capuano Early Childhood Center. The brochure was paid for by the Massachusetts Technology Collaborative as part of their Green Schools Initiative. High-performance features described are daylighting and energy-efficient lighting, indoor air quality, solar and wind energy, building envelope, heating and cooling systems, water conservation, and acoustics. Energy cost savings are also discussed.

  12. Stereodivergent Organocatalytic Intramolecular Michael Addition/Lactonization for the Asymmetric Synthesis of Substituted Dihydrobenzofurans and Tetrahydrofurans

    PubMed Central

    Belmessieri, Dorine; de la Houpliere, Alix; Calder, Ewen D D; Taylor, James E; Smith, Andrew D

    2014-01-01

    A stereodivergent asymmetric Lewis base catalyzed Michael addition/lactonization of enone acids into substituted dihydrobenzofuran and tetrahydrofuran derivatives is reported. Commercially available (S)-(−)-tetramisole hydrochloride gives products with high syn diastereoselectivity in excellent enantioselectivity (up to 99:1 d.r.syn/anti, 99 % eesyn), whereas using a cinchona alkaloid derived catalyst gives the corresponding anti-diastereoisomers as the major product (up to 10:90 d.r.syn/anti, 99 % eeanti). PMID:24989672

  13. Michael C. Roberts: award for distinguished contributions to education and training in psychology.

    PubMed

    2006-11-01

    Presents a citation for Michael C. Roberts, who received the Award for Distinguished Contributions to Education and Training in Psychology "for his dedication to the education, training, and mentoring of psychologists from undergraduate study through professional career." Accompanying the citation are a brief profile and a selected bibliography, as well as Roberts' award address, entitled Essential Tension: Specialization With Broad and General Training in Psychology. ((c) 2006 APA, all rights reserved). PMID:17115832

  14. Michael Cole: award for distinguished contributions to the international advancement of psychology.

    PubMed

    2006-11-01

    Presents the citation for Michael Cole, who received the Award for Distinguished Contributions to the International Advancement of Psychology "for his significant and influential contributions to understanding the cultural and historical construction of human life and the implications of collective social practices for human development." Accompanying the citation are a brief profile and a selected bibliography, as well as Cole's award address, entitled Internationalism in Psychology: We Need It Now More Than Ever. ((c) 2006 APA, all rights reserved). PMID:17115848

  15. Quantum correlations through event horizons: Fermionic versus bosonic entanglement

    SciTech Connect

    Martin-Martinez, Eduardo; Leon, Juan

    2010-03-15

    We disclose the behavior of quantum and classical correlations among all the different spatial-temporal regions of a space-time with an event horizon, comparing fermionic with bosonic fields. We show the emergence of conservation laws for entanglement and classical correlations, pointing out the crucial role that statistics plays in the information exchange (and more specifically, the entanglement tradeoff) across horizons. The results obtained here could shed new light on the problem of information behavior in noninertial frames and in the presence of horizons, giving better insight into the black-hole information paradox.

  16. Quantum correlations through event horizons: Fermionic versus bosonic entanglement

    NASA Astrophysics Data System (ADS)

    Martín-Martínez, Eduardo; León, Juan

    2010-03-01

    We disclose the behavior of quantum and classical correlations among all the different spatial-temporal regions of a space-time with an event horizon, comparing fermionic with bosonic fields. We show the emergence of conservation laws for entanglement and classical correlations, pointing out the crucial role that statistics plays in the information exchange (and more specifically, the entanglement tradeoff) across horizons. The results obtained here could shed new light on the problem of information behavior in noninertial frames and in the presence of horizons, giving better insight into the black-hole information paradox.

  17. Horizon scan of global conservation issues for 2011.

    PubMed

    Sutherland, William J; Bardsley, Sarah; Bennun, Leon; Clout, Mick; Côté, Isabelle M; Depledge, Michael H; Dicks, Lynn V; Dobson, Andrew P; Fellman, Liz; Fleishman, Erica; Gibbons, David W; Impey, Andrew J; Lawton, John H; Lickorish, Fiona; Lindenmayer, David B; Lovejoy, Thomas E; Nally, Ralph Mac; Madgwick, Jane; Peck, Lloyd S; Pretty, Jules; Prior, Stephanie V; Redford, Kent H; Scharlemann, Jörn P W; Spalding, Mark; Watkinson, Andrew R

    2011-01-01

    This review describes outcomes of a 2010 horizon-scanning exercise building upon the first exercise conducted in 2009. The aim of both horizon scans was to identify emerging issues that could have substantial impacts on the conservation of biological diversity, and to do so sufficiently early to encourage policy-relevant, practical research on those issues. Our group included professional horizon scanners and researchers affiliated with universities and non- and inter-governmental organizations, including specialists on topics such as invasive species, wildlife diseases and coral reefs. We identified 15 nascent issues, including new greenhouse gases, genetic techniques to eradicate mosquitoes, milk consumption in Asia and societal pessimism. PMID:21126797

  18. Area Theorem and Smoothness of Compact Cauchy Horizons

    NASA Astrophysics Data System (ADS)

    Minguzzi, E.

    2015-10-01

    We obtain an improved version of the area theorem for not necessarily differentiable horizons which, in conjunction with a recent result on the completeness of generators, allows us to prove that under the null energy condition every compactly generated Cauchy horizon is smooth and compact. We explore the consequences of this result for time machines, topology change, black holes and cosmic censorship. For instance, it is shown that compact Cauchy horizons cannot form in a non-empty spacetime which satisfies the stable dominant energy condition wherever there is some source content.

  19. 78 FR 2390 - CAlifornians for Renewable Energy, Inc., Michael E. Boyd, Robert M. Sarvey, v. Pacific Gas and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-11

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission CAlifornians for Renewable Energy, Inc., Michael E. Boyd, Robert M. Sarvey... Practice and Procedure (Rules) of the Federal ] Energy Regulatory Commission (FERC), CAlifornians...

  20. Surface Modified Particles By Multi-Step Michael-Type Addition And Process For The Preparation Thereof

    SciTech Connect

    Cook, Ronald Lee; Elliott, Brian John; Luebben, Silvia DeVito; Myers, Andrew William; Smith, Bryan Matthew

    2005-05-03

    A new class of surface modified particles and a multi-step Michael-type addition surface modification process for the preparation of the same is provided. The multi-step Michael-type addition surface modification process involves two or more reactions to compatibilize particles with various host systems and/or to provide the particles with particular chemical reactivities. The initial step comprises the attachment of a small organic compound to the surface of the inorganic particle. The subsequent steps attach additional compounds to the previously attached organic compounds through reactive organic linking groups. Specifically, these reactive groups are activated carbon—carbon pi bonds and carbon and non-carbon nucleophiles that react via Michael or Michael-type additions.

  1. Exact event horizon of a black hole merger

    NASA Astrophysics Data System (ADS)

    Emparan, Roberto; Martínez, Marina

    2016-08-01

    We argue that the event horizon of a binary black hole merger, in the extreme-mass-ratio limit where one of the black holes is much smaller than the other, can be described in an exact analytic way. This is done by tracing in the Schwarzschild geometry a congruence of null geodesics that approaches a null plane at infinity. Its form can be given explicitly in terms of elliptic functions, and we use it to analyze and illustrate the time-evolution of the horizon along the merger. We identify features such as the line of caustics at which light rays enter the horizon, and the critical point at which the horizons touch. We also compute several quantities that characterize these aspects of the merger.

  2. Complementary and Alternative Medicine (CAM): Expanding Horizons of Health Care

    MedlinePlus

    ... Past Issues Special Section CAM Expanding Horizons of Health Care Past Issues / Winter 2009 Table of Contents For ... and why it is important to tell your health care providers about your use of CAM. We hope ...

  3. The absence of horizon in black-hole formation

    NASA Astrophysics Data System (ADS)

    Ho, Pei-Ming

    2016-08-01

    With the back-reaction of Hawking radiation taken into consideration, the work of Kawai, Matsuo and Yokokura [1] has shown that, under a few assumptions, the collapse of matter does not lead to event horizon nor apparent horizon. In this paper, we relax their assumptions and elaborate on the space-time geometry of a generic collapsing body with spherical symmetry. The geometry outside the collapsing sphere is found to be approximated by the geometry outside the white-hole horizon, hence the collapsing matter remains outside the Schwarzschild radius. As particles in Hawking radiation are created in the vicinity of the collapsing matter, the information loss paradox is alleviated. Assuming that the collapsing body evaporates within finite time, there is no event horizon.

  4. Entanglement entropy of a black hole and isolated horizon

    NASA Astrophysics Data System (ADS)

    Shi, Jianhua; Hu, Shuangqi; Zhao, Ren

    2013-02-01

    Using Unruh-Verlinde temperature obtained by entropic force, we directly calculate partition functions of quantum field in Schwarzschild spacetime via quantum statistical method and derive the expression of the black hole statistical entropy. In our calculation the lower limit of integral is the location of isolated horizon introduced in loop quantum gravity and the upper limit of integral is infinity. So the obtained entropy is the statistical entropy from isolated horizon to the infinite. In our calculation there are not the cutoff and approximation. The results showed that, as long as proper Immirzi parameters are selected, the entropy obtained by loop quantum gravity is consistent with the quantum statistical entropy outside the black hole horizon. Therefore the black hole entropy is a quantum entanglement entropy outside the isolated horizon.

  5. Note on electrical and thermodynamic properties of isolated horizons

    NASA Astrophysics Data System (ADS)

    Chen, Gerui; Wu, Xiaoning; Gao, Sijie

    2015-03-01

    The electrical laws and Carnot cycle of isolated horizons (IH) are investigated in this paper. We establish Ohm's law and Joule's law of isolated horizons and find that the conceptual picture of black holes (membrane paradigm) can also apply to this kind of quasilocal black holes. We also investigate the geometrical properties near nonrotating IHs and find that under the first-order approximation of r , there exist a Killing vector ∂∂u/ and a Hamiltonian conjugate to it, so this vector can be thought to be a physical observer. We calculate the energy as measured at infinity of a particle at rest outside a nonrotating IH, and we use this result to construct a reversible Carnot cycle with the isolated horizon as a cold reservoir, which confirms the thermodynamic nature of isolated horizons.

  6. JERSEY APPROACH VIADUCT LOOKING EAST, NOTE VERRAZANO TOWERS ON HORIZON ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    JERSEY APPROACH VIADUCT LOOKING EAST, NOTE VERRAZANO TOWERS ON HORIZON TO LEFT - Goethals Bridge, Spanning Arthur Kill from New Jersey to Staten Island, Staten Island (subdivision), Richmond County, NY

  7. Universal properties of the near-horizon optical geometry

    NASA Astrophysics Data System (ADS)

    Gibbons, G. W.; Warnick, C. M.

    2009-03-01

    Making use of the fact that the optical geometry near a static nondegenerate Killing horizon is asymptotically hyperbolic, we investigate some universal features of black-hole horizons. Applying the Gauss-Bonnet theorem allows us to establish some general properties of gravitational lensing, valid for all black holes. Hyperbolic geometry allows us to find rates for the loss of scalar, vector, and fermionic “hair” as objects fall quasistatically towards the horizon, extending previous results for Schwarzschild to all static Killing horizons. In the process we find the Liénard-Wiechert potential for hyperbolic space and calculate the force between electrons mediated by neutrinos, extending the flat space result of Feinberg and Sucher. We further demonstrate how these techniques allow us to derive the exact Copson-Linet potential due to a point charge in a Schwarzschild background in a simple fashion.

  8. The Cauchy horizon singularity inside Kerr black holes

    NASA Astrophysics Data System (ADS)

    Burko, Lior M.; Khanna, Gaurav

    2016-03-01

    The numerical technology that allows for the careful evolution of linearized fields inside Kerr black holes and the study of their behavior approaching the Cauchy horizon singularity includes a number of interesting aspects. The latter include compactified hyperboloidal coordinates and foliation, mixed type hyperbolic-elliptic PDE, and initial data evolution where all equal-coordinate hypersurfaces are spacelike. We review the need for the numerical technology that allows for the solution of the spin-2 Teukolsky equation inside Kerr black holes, and discuss the main features thereof. We present new results about the numerical properties of the Cauchy horizon singularity and their correspondence with the predictions of perturbative analysis. We then discuss present directions of study, which include the sub-dominant azimuthal modes, approaching the Cauchy horizon singularity along timelike directions, approaching the Marolf-Ori (``outflying'') singularity and the studying the fields along the Cauchy horizon.

  9. Universal properties of the near-horizon optical geometry

    SciTech Connect

    Gibbons, G. W.; Warnick, C. M.

    2009-03-15

    Making use of the fact that the optical geometry near a static nondegenerate Killing horizon is asymptotically hyperbolic, we investigate some universal features of black-hole horizons. Applying the Gauss-Bonnet theorem allows us to establish some general properties of gravitational lensing, valid for all black holes. Hyperbolic geometry allows us to find rates for the loss of scalar, vector, and fermionic ''hair'' as objects fall quasistatically towards the horizon, extending previous results for Schwarzschild to all static Killing horizons. In the process we find the Lienard-Wiechert potential for hyperbolic space and calculate the force between electrons mediated by neutrinos, extending the flat space result of Feinberg and Sucher. We further demonstrate how these techniques allow us to derive the exact Copson-Linet potential due to a point charge in a Schwarzschild background in a simple fashion.

  10. Cutoffs, stretched horizons, and black hole radiators

    NASA Astrophysics Data System (ADS)

    Kaloper, Nemanja

    2012-11-01

    We argue that if the UV cutoff of an effective field theory with many low energy degrees of freedom is of the order, or below, the scale of the stretched horizon in a black hole background, which in turn is significantly lower than the Planck scale, the black hole radiance rate may not be enhanced by the emission of all the light IR modes. Instead, there may be additional suppressions hidden in the UV completion of the field theory, which really control which light modes can be emitted by the black hole. It could turn out that many degrees of freedom cannot be efficiently emitted by the black hole, and so the radiance rate may be much smaller than its estimate based on the counting of the light IR degrees of freedom. If we apply this argument to the Randall-Sundrum II (RS2) brane world, it implies that the emission rates of the low energy conformal field theory modes will be dramatically suppressed: its UV completion is given by the bulk gravity on AdS5×S5, and the only bulk modes which could be emitted by a black hole are the 4-dimensional (4D) s waves of bulk modes with small 5-dimensional momentum, or equivalently, small 4D masses. Further, their emission is suppressed by bulk warping, which lowers the radiation rate much below the IR estimate, yielding a radiation flux ˜(TBHL)2LHawking˜(TBH/MPl)2NLHawking, where LHawking is the Hawking radiation rate of a single light species. This follows directly from low conformal field theory cutoff μ˜L-1≪MPl, a large number of modes N≫1 and the fact that 4D gravity in RS2 is induced, MPl2≃Nμ2.

  11. The New Horizons Radio Science Experiment (REX)

    NASA Astrophysics Data System (ADS)

    Tyler, G. L.; Linscott, I. R.; Bird, M. K.; Hinson, D. P.; Strobel, D. F.; Pätzold, M.; Summers, M. E.; Sivaramakrishnan, K.

    2008-10-01

    The New Horizons (NH) Radio Science Experiment, REX, is designed to determine the atmospheric state at the surface of Pluto and in the lowest few scale heights. Expected absolute accuracies in n, p, and T at the surface are 4ṡ1019 m-3, 0.1 Pa, and 3 K, respectively, obtained by radio occultation of a 4.2 cm- λ signal transmitted from Earth at 10-30 kW and received at the NH spacecraft. The threshold for ionospheric observations is roughly 2ṡ109 e- m-3. Radio occultation experiments are planned for both Pluto and Charon, but the level of accuracy for the neutral gas is expected to be useful at Pluto only. REX will also measure the nightside 4.2 cm- λ thermal emission from Pluto and Charon during the time NH is occulted. At Pluto, the thermal scan provides about five half-beams across the disk; at Charon, only disk integrated values can be obtained. A combination of two-way tracking and occultation signals will determine the Pluto system mass to about 0.01 percent, and improve the Pluto-Charon mass ratio. REX flight equipment augments the NH radio transceiver used for spacecraft communications and tracking. Implementation of REX required realization of a new CIC-SCIC signal processing algorithm; the REX hardware implementation requires 1.6 W, and has mass of 160 g in 520 cm3. Commissioning tests conducted after NH launch demonstrate that the REX system is operating as expected.

  12. Output-feedback control of combined sewer networks through receding horizon control with moving horizon estimation

    NASA Astrophysics Data System (ADS)

    Joseph-Duran, Bernat; Ocampo-Martinez, Carlos; Cembrano, Gabriela

    2015-10-01

    An output-feedback control strategy for pollution mitigation in combined sewer networks is presented. The proposed strategy provides means to apply model-based predictive control to large-scale sewer networks, in-spite of the lack of measurements at most of the network sewers. In previous works, the authors presented a hybrid linear control-oriented model for sewer networks together with the formulation of Optimal Control Problems (OCP) and State Estimation Problems (SEP). By iteratively solving these problems, preliminary Receding Horizon Control with Moving Horizon Estimation (RHC/MHE) results, based on flow measurements, were also obtained. In this work, the RHC/MHE algorithm has been extended to take into account both flow and water level measurements and the resulting control loop has been extensively simulated to assess the system performance according different measurement availability scenarios and rain events. All simulations have been carried out using a detailed physically based model of a real case-study network as virtual reality.

  13. A horizon scan of global conservation issues for 2015.

    PubMed

    Sutherland, William J; Clout, Mick; Depledge, Michael; Dicks, Lynn V; Dinsdale, Jason; Entwistle, Abigail C; Fleishman, Erica; Gibbons, David W; Keim, Brandon; Lickorish, Fiona A; Monk, Kathryn A; Ockendon, Nancy; Peck, Lloyd S; Pretty, Jules; Rockström, Johan; Spalding, Mark D; Tonneijck, Femke H; Wintle, Bonnie C

    2015-01-01

    This paper presents the results of our sixth annual horizon scan, which aims to identify phenomena that may have substantial effects on the global environment, but are not widely known or well understood. A group of professional horizon scanners, researchers, practitioners, and a journalist identified 15 topics via an iterative, Delphi-like process. The topics include a novel class of insecticide compounds, legalisation of recreational drugs, and the emergence of a new ecosystem associated with ice retreat in the Antarctic. PMID:25433442

  14. Supertranslations and Superrotations at the Black Hole Horizon

    NASA Astrophysics Data System (ADS)

    Donnay, Laura; Giribet, Gaston; González, Hernán A.; Pino, Miguel

    2016-03-01

    We show that the asymptotic symmetries close to nonextremal black hole horizons are generated by an extension of supertranslations. This group is generated by a semidirect sum of Virasoro and Abelian currents. The charges associated with the asymptotic Killing symmetries satisfy the same algebra. When considering the special case of a stationary black hole, the zero mode charges correspond to the angular momentum and the entropy at the horizon.

  15. A horizon scan of global conservation issues for 2013.

    PubMed

    Sutherland, William J; Bardsley, Sarah; Clout, Mick; Depledge, Michael H; Dicks, Lynn V; Fellman, Liz; Fleishman, Erica; Gibbons, David W; Keim, Brandon; Lickorish, Fiona; Margerison, Ceri; Monk, Kathryn A; Norris, Kenneth; Peck, Lloyd S; Prior, Stephanie V; Scharlemann, Jörn P W; Spalding, Mark D; Watkinson, Andrew R

    2013-01-01

    This paper presents the findings of our fourth annual horizon-scanning exercise, which aims to identify topics that increasingly may affect conservation of biological diversity. The 15 issues were identified via an iterative, transferable process by a team of professional horizon scanners, researchers, practitioners, and a journalist. The 15 topics include the commercial use of antimicrobial peptides, thorium-fuelled nuclear power, and undersea oil production. PMID:23219597

  16. Supertranslations and Superrotations at the Black Hole Horizon.

    PubMed

    Donnay, Laura; Giribet, Gaston; González, Hernán A; Pino, Miguel

    2016-03-01

    We show that the asymptotic symmetries close to nonextremal black hole horizons are generated by an extension of supertranslations. This group is generated by a semidirect sum of Virasoro and Abelian currents. The charges associated with the asymptotic Killing symmetries satisfy the same algebra. When considering the special case of a stationary black hole, the zero mode charges correspond to the angular momentum and the entropy at the horizon. PMID:26991167

  17. Optical Navigation Preparations for New Horizons Pluto Flyby

    NASA Technical Reports Server (NTRS)

    Owen, William M., Jr.; Dumont, Philip J.; Jackman, Coralie D.

    2012-01-01

    The New Horizons spacecraft will encounter Pluto and its satellites in July 2015. As was the case for the Voyager encounters with Jupiter, Saturn, Uranus and Neptune, mission success will depend heavily on accurate spacecraft navigation, and accurate navigation will be impossible without the use of pictures of the Pluto system taken by the onboard cameras. We describe the preparations made by the New Horizons optical navigators: picture planning, image processing algorithms, software development and testing, and results from in-flight imaging.

  18. Thermodynamics of cosmological horizons in f(T) gravity

    SciTech Connect

    Bamba, Kazuharu; Geng, Chao-Qiang E-mail: geng@phys.nthu.edu.tw

    2011-11-01

    We explore thermodynamics of the apparent horizon in f(T) gravity with both equilibrium and non-equilibrium descriptions. We find the same dual equilibrium/non-equilibrium formulation for f(T) as for f(R) gravity. In particular, we show that the second law of thermodynamics can be satisfied for the universe with the same temperature outside and inside the apparent horizon.

  19. Deformation of codimension-2 surfaces and horizon thermodynamics

    NASA Astrophysics Data System (ADS)

    Cao, Li-Ming

    2011-03-01

    The deformation equation of a spacelike submanifold with an arbitrary codimension is given by a general construction without using local frames. In the case of codimension-1, this equation reduces to the evolution equation of the extrinsic curvature of a spacelike hypersurface. In the more interesting case of codimension-2, after selecting a local null frame, this deformation equation reduces to the well known (cross) focusing equations. We show how the thermodynamics of trapping horizons is related to these deformation equations in two different formalisms: with and without introducing quasilocal energy. In the formalism with the quasilocal energy, the Hawking mass in four dimension is generalized to higher dimension, and it is found that the deformation of this energy inside a marginal surface can be also decomposed into the contributions from matter fields and gravitational radiation as in the four dimension. In the formalism without the quasilocal energy, we generalize the definition of slowly evolving future outer trapping horizons proposed by Booth to past trapping horizons. The dynamics of the trapping horizons in FLRW universe is given as an example. Especially, the slowly evolving past trapping horizon in the FLRW universe has close relation to the scenario of slow-roll inflation. Up to the second order of the slowly evolving parameter in this generalization, the temperature (surface gravity) associated with the slowly evolving trapping horizon in the FLRW universe is essentially the same as the one defined by using the quasilocal energy.

  20. Development of a Fragment-Based in Silico Profiler for Michael Addition Thiol Reactivity.

    PubMed

    Ebbrell, David J; Madden, Judith C; Cronin, Mark T D; Schultz, Terry W; Enoch, Steven J

    2016-06-20

    The Adverse Outcome Pathway (AOP) paradigm details the existing knowledge that links the initial interaction between a chemical and a biological system, termed the molecular initiating event (MIE), through a series of intermediate events, to an adverse effect. An important example of a well-defined MIE is the formation of a covalent bond between a biological nucleophile and an electrophilic compound. This particular MIE has been associated with various toxicological end points such as acute aquatic toxicity, skin sensitization, and respiratory sensitization. This study has investigated the calculated parameters that are required to predict the rate of chemical bond formation (reactivity) of a dataset of Michael acceptors. Reactivity of these compounds toward glutathione was predicted using a combination of a calculated activation energy value (Eact, calculated using density functional theory (DFT) calculation at the B3YLP/6-31G+(d) level of theory, and solvent-accessible surface area values (SAS) at the α carbon. To further develop the method, a fragment-based algorithm was developed enabling the reactivity to be predicted for Michael acceptors without the need to perform the time-consuming DFT calculations. Results showed the developed fragment method was successful in predicting the reactivity of the Michael acceptors excluding two sets of chemicals: volatile esters with an extended substituent at the β-carbon and chemicals containing a conjugated benzene ring as part of the polarizing group. Additionally the study also demonstrated the ease with which the approach can be extended to other chemical classes by the calculation of additional fragments and their associated Eact and SAS values. The resulting method is likely to be of use in regulatory toxicology tools where an understanding of covalent bond formation as a potential MIE is important within the AOP paradigm. PMID:27100370

  1. [The problem of evil in families--the filmmaker Michael Haneke].

    PubMed

    Skårderud, Finn

    2010-09-23

    With the beautiful and dark film "The white ribbon", from 2009, the Austrian film director Michael Haneke consolidated his status as an international success. A central theme in his films is evilness and its roots. But just as important is his ambition to develop films where evil is not only portrayed, but where spectators are challenged to relate to their own ethical standards and their role as spectators. Haneke is a highly original filmmaker with his consistent search for a film aesthetic that stimulates ethical self-reflection and mentalizing. He partly succeeds in this quest. PMID:20882085

  2. Supported bifunctional thioureas as recoverable and reusable catalysts for enantioselective nitro-Michael reactions

    PubMed Central

    Ceballos, Miriam; Maestro, Alicia; Sanz, Isabel

    2016-01-01

    Summary The catalytic activity of different supported bifunctional thioureas on sulfonylpolystyrene resins has been studied in the nitro-Michael addition of different nucleophiles to trans-β-nitrostyrene derivatives. The activity of the catalysts depends on the length of the tether linking the chiral thiourea to the polymer. The best results were obtained with the thiourea derived from (L)-valine and 1,6-hexanediamine. The catalysts can be used in only 2 mol % loading, and reused for at least four cycles in neat conditions. The ball milling promoted additions also worked very well. PMID:27340453

  3. Michael Servetus (1511-1553): physician and heretic who described the pulmonary circulation.

    PubMed

    Bosmia, Anand; Watanabe, Koichi; Shoja, Mohammadali M; Loukas, Marios; Tubbs, R Shane

    2013-07-31

    The purpose of this paper is to provide an overview of the life of the physician and theologian Michael Servetus and to discuss his analysis of the pulmonary circulation. Writers have praised Servetus for his commitment to educating his colleagues about what he heralded as the truth, and criticized him for his perceived arrogance. Servetus made contributions to the fields of geography, astrology, theology, and medicine. This paper refers to the translation of a portion of Servetus' book Christianismi Restitutio by Charles D. O'Malley. PMID:22748500

  4. A Promiscuous De Novo Retro-Aldolase Catalyzes Asymmetric Michael Additions via Schiff Base Intermediates.

    PubMed

    Garrabou, Xavier; Beck, Tobias; Hilvert, Donald

    2015-05-01

    Recent advances in computational design have enabled the development of primitive enzymes for a range of mechanistically distinct reactions. Here we show that the rudimentary active sites of these catalysts can give rise to useful chemical promiscuity. Specifically, RA95.5-8, designed and evolved as a retro-aldolase, also promotes asymmetric Michael additions of carbanions to unsaturated ketones with high rates and selectivities. The reactions proceed by amine catalysis, as indicated by mutagenesis and X-ray data. The inherent flexibility and tunability of this catalyst should make it a versatile platform for further optimization and/or mechanistic diversification by directed evolution. PMID:25777153

  5. Enzyme-Catalyzed Asymmetric Domino Thia-Michael/Aldol Condensation Using Pepsin.

    PubMed

    Xiang, Yang; Song, Jian; Zhang, Yong; Yang, Da-Cheng; Guan, Zhi; He, Yan-Hong

    2016-07-15

    The novel catalytic promiscuity of pepsin from porcine gastric mucosa for the asymmetric catalysis of the domino thia-Michael/aldol condensation reaction in MeCN and buffer was discovered for the first time. Broad substrate specificity was tested, and a series of corresponding products were obtained with enantioselectivities of up to 84% ee. This specific catalysis was demonstrated by using recombinant pepsin and control experiments with denatured and inhibited pepsin. The reaction was also shown to occur in the active site by site-directed mutagenesis (the Asp32Ala mutant of pepsin), and a possible mechanism was proposed. PMID:27348476

  6. Bioactive diterpenoid containing a reversible "spring-loaded" (E,Z)-dieneone Michael acceptor.

    PubMed

    Gupta, Prasoon; Sharma, Upasana; Schulz, Thomas C; Sherrer, Eric S; McLean, Amanda B; Robins, Allan J; West, Lyndon M

    2011-08-01

    Three new briarane diterpenoids, briareolate esters L-N (1-3), have been isolated from a gorgonian Briareum asbestinum. Briareolate esters L (1) and M (2) are the first natural products possessing a 10-membered macrocyclic ring with a (E,Z)-dieneone and exhibit growth inhibition activity against both human embryonic stem cells (BG02) and a pancreatic cancer cell line (BxPC-3). Briareolate ester L (1) was found to contain a "spring-loaded" (E,Z)-dieneone Michael acceptor group that can form a reversible covalent bond to model sulfur-based nucleophiles. PMID:21749084

  7. Michael E. Lamb: Award for Distinguished Senior Career Contributions to Psychology in the Public Interest.

    PubMed

    2015-11-01

    The APA Awards for Distinguished Contributions to Psychology in the Public Interest recognize persons who have advanced psychology as a science and/or profession by a single extraordinary achievement or a lifetime of outstanding contributions in the public interest. The 2015 co-recipient of the Award for Distinguished Senior Career Contributions to Psychology in the Public Interest is Michael E. Lamb. Lamb was selected because his "work profoundly shaped the fields of developmental psychology, social welfare, child and family policy, and law." Lamb's award citation, biography, and a selected bibliography are presented here. PMID:26618955

  8. Conversion of Substrate Analogs Suggests a Michael Cyclization in Iridoid Biosynthesis

    PubMed Central

    Lindner, Stephanie; Geu-Flores, Fernando; Bräse, Stefan; Sherden, Nathaniel H.; O’Connor, Sarah E.

    2014-01-01

    Summary The core structure of the iridoid monoterpenes is formed by a unique cyclization reaction. The enzyme that catalyzes this reaction, iridoid synthase, is mechanistically distinct from other terpene cyclases. Here we describe the synthesis of two substrate analogs to probe the mechanism of iridoid synthase. Enzymatic assay of these substrate analogs along with clues from the product profile of the native substrate strongly suggest that iridoid synthase utilizes a Michael reaction to achieve cyclization. This improved mechanistic understanding will facilitate the exploitation of the potential of iridoid synthase to synthesize new cyclic compounds from nonnatural substrates. PMID:25444551

  9. Intrinsic geometry of a tidally deformed Kerr horizon

    NASA Astrophysics Data System (ADS)

    Poisson, Eric

    2013-04-01

    The intrinsic metric of a tidally deformed black-hole horizon can be presented in a coordinate system adapted to the horizon's null generators, with one coordinate acting as a running parameter along each generator, and two coordinates acting as constant generator labels. The metric is invariant under reparametrizations of the generators, and as such the horizon's intrinsic geometry is known to be gauge invariant. We consider a Kerr black hole deformed by a slowly-evolving external tidal field, and describe the intrinsic geometry of its event horizon in terms of the electric and magnetic tidal moments that characterize the tidal environment. When the black hole is slowly rotating, the horizon's geometry can be described in terms of a deviation from an otherwise spherical surface, and the deformation can be characterized by gauge invariant Love numbers. Some aspects of this tidal deformation have direct analogues in Newtonian physics. Some do not, and I will describe the similarities and differences between the tidal deformation of rotating black holes in general relativity and rotating fluid bodies in Newtonian physics.

  10. Beyond the veil: Inner horizon instability and holography

    SciTech Connect

    Balasubramanian, Vijay; Levi, Thomas S.

    2004-11-15

    We show that scalar perturbations of the eternal, rotating Banados-Teitelboim-Zanelli (BTZ) black hole should lead to an instability of the inner (Cauchy) horizon, preserving strong cosmic censorship. Because of backscattering from the geometry, plane-wave modes have a divergent stress tensor at the event horizon, but suitable wave packets avoid this difficulty, and are dominated at late times by quasinormal behavior. The wave packets have cuts in the complexified coordinate plane that are controlled by requirements of continuity, single-valuedness, and positive energy. Due to a focusing effect, regular wave packets nevertheless have a divergent stress energy at the inner horizon, signaling an instability. We propose that this instability, which is localized behind the event horizon, is detected holographically as a breakdown in the semiclassical computation of dual conformal field theory (CFT) expectation values in which the analytic behavior of wave packets in the complexified coordinate plane plays an integral role. In the dual field theory, this is interpreted as an encoding of physics behind the horizon in the entanglement between otherwise independent CFTs.

  11. Quantization of Horizon Entropy and the Thermodynamics of Spacetime

    NASA Astrophysics Data System (ADS)

    Skákala, Jozef

    2014-06-01

    This is a review of my work published in the papers of Skakala (JHEP 1201:144, 2012; JHEP 1206:094, 2012) and Chirenti et al. (Phys. Rev. D 86:124008, 2012; Phys. Rev. D 87:044034, 2013). It offers a more detailed discussion of the results than the accounts in those papers, and it links my results to some conclusions recently reached by other authors. It also offers some new arguments supporting the conclusions in the cited articles. The fundamental idea of this work is that the semiclassical quantization of the black hole entropy, as suggested by Bekenstein (Phys. Rev. D 7:2333-2346, 1973), holds (at least) generically for the spacetime horizons. We support this conclusion by two separate arguments: (1) we generalize Bekenstein's lower bound on the horizon area transition to a much wider class of horizons than only the black-hole horizon, and (2) we obtain the same entropy spectra via the asymptotic quasi-normal frequencies of some particular spherically symmetric multi-horizon spacetimes (in the way proposed by Maggiore (Phys. Rev. Lett. 100:141301, 2008)). The main result of this paper supports the conclusions derived by Kothawalla et al. (Phys. Rev. D 78:104018, 2008) and Kwon and Nam (Class. Quant. Grav. 28:035007, 2011), on the basis of different arguments.

  12. Dynamical horizon entropy and equilibrium thermodynamics of generalized gravity theories

    SciTech Connect

    Wu Shaofeng; Ge Xianhui; Yang Guohong; Zhang Pengming

    2010-02-15

    We study the relation between the thermodynamics and field equations of generalized gravity theories on the dynamical trapping horizon with sphere symmetry. We assume the entropy of a dynamical horizon as the Noether charge associated with the Kodama vector and point out that it satisfies the second law when a Gibbs equation holds. We generalize two kinds of Gibbs equations to Gauss-Bonnet gravity on any trapping horizon. Based on the quasilocal gravitational energy found recently for f(R) gravity and scalar-tensor gravity in some special cases, we also build up the Gibbs equations, where the nonequilibrium entropy production, which is usually invoked to balance the energy conservation, is just absorbed into the modified Wald entropy in the Friedmann-Robertson-Walker spacetime with slowly varying horizon. Moreover, the equilibrium thermodynamic identity remains valid for f(R) gravity in a static spacetime. Our work provides an alternative treatment to reinterpret the nonequilibrium correction and supports the idea that the horizon thermodynamics is universal for generalized gravity theories.

  13. Evaluation of GPS Coverage for the X-33 Michael-6 Trajectory

    NASA Technical Reports Server (NTRS)

    Lundberg, John B.

    1998-01-01

    The onboard navigational system for the X-33 test flights will be based on the use of measurements collected from the Embedded Global Positioning System (GPS)/INS system. Some of the factors which will affect the quality of the GPS contribution to the navigational solution will be the number of pseudorange measurements collected at any instant in time, the distribution of the GPS satellites within the field of view, and the inherent noise level of the GPS receiver. The distribution of GPS satellites within the field of view of the receiver's antenna will depend on the receiver's position, the time of day, pointing direction of the antenna, and the effective cone angle of the antenna. The number of pseudorange measurements collected will depend upon these factors as well as the time required to lock onto a GPS satellite signal once the GPS satellite comes into the field of view of the antenna and the number of available receiver channels. The objective of this study is to evaluate the GPS coverage resulting from the proposed antenna pointing directions, the proposed antenna cone angles, and the effects due to the time of day for the X-33 Michael-6 trajectory from launch at Edwards AFB, California, to the start of the Terminal Area Energy Management (TAEM) phase on approach to Michael AAF, Utah.

  14. Sustained release formulation of erythropoietin using hyaluronic acid hydrogels crosslinked by Michael addition.

    PubMed

    Hahn, Sei Kwang; Oh, Eun Ju; Miyamoto, Hajime; Shimobouji, Tsuyoshi

    2006-09-28

    A novel sustained release formulation of erythropoietin (EPO) was successfully developed using hyaluronic acid (HA) hydrogels crosslinked by Michael addition. Adipic acid dihydrazide grafted HA (HA-ADH) was prepared and then modified into methacrylated HA (HA-MA). (1)H NMR analysis showed that the degrees of HA-ADH and HA-MA modification were 69 and 29 mol%, respectively. Using the specific crosslinkers of dithiothreitol (DTT) and peptide linker, EPO was loaded during HA-MA hydrogel preparation by Michael addition chemistry between thiol and methacrylate groups. The amount of EPO recovered from both hydrogels after degradation with hyaluronidase SD (HAse SD) was about 90%. The crosslinking reaction with peptide linker (GCYKNRDCG) was faster than that with DTT. The gelation time was about 30 min for peptide linker and 180 min for DTT. In vitro release test of EPO from HA-MA hydrogel at 37 degrees C showed that EPO was released rapidly for 2 days and then slowly up to 7 days from HA-MA hydrogels. The released EPO appeared to be intact from the analysis with RP-HPLC. According to in vivo release test of EPO from HA-MA hydrogels crosslinked with the peptide linker in Sprague-Dawley (SD) rats, elevated plasma concentration of EPO was maintained up to 7 days. There was no adverse effect during and after the in vivo tests. PMID:16781096

  15. Cinchona Alkaloid Catalyzed Sulfa-Michael Addition Reactions Leading to Enantiopure β-Functionalized Cysteines.

    PubMed

    Breman, Arjen C; Telderman, Suze E M; van Santen, Roy P M; Scott, Jamie I; van Maarseveen, Jan H; Ingemann, Steen; Hiemstra, Henk

    2015-11-01

    Sulfa-Michael additions to α,β-unsaturated N-acylated oxazolidin-2-ones and related α,β-unsaturated α-amino acid derivatives have been enantioselectively catalyzed by Cinchona alkaloids functionalized with a hydrogen bond donating group at the C6' position. The series of Cinchona alkaloids includes known C6' (thio)urea and sulfonamide derivatives and several novel species with a benzimidazole, squaramide or a benzamide group at the C6' position. The sulfonamides were especially suited as bifunctional organocatalysts as they gave the products in very good diastereoselectivity and high enantioselectivity. In particular, the C6' sulfonamides catalyzed the reaction with the α,β-unsaturated α-amino acid derivatives to afford the products in a diastereomeric ratio as good as 93:7, with the major isomer being formed in an ee of up to 99%. The products of the organocatalytic sulfa-Michael addition to α,β-unsaturated α-amino acid derivatives were subsequently converted in high yields to enantiopure β-functionalized cysteines suitable for native chemical ligation. PMID:26451627

  16. Construction of the SILAM Eulerian atmospheric dispersion model based on the advection algorithm of Michael Galperin

    NASA Astrophysics Data System (ADS)

    Sofiev, M.; Vira, J.; Kouznetsov, R.; Prank, M.; Soares, J.; Genikhovich, E.

    2015-11-01

    The paper presents the transport module of the System for Integrated modeLling of Atmospheric coMposition SILAM v.5 based on the advection algorithm of Michael Galperin. This advection routine, so far weakly presented in the international literature, is positively defined, stable at any Courant number, and efficient computationally. We present the rigorous description of its original version, along with several updates that improve its monotonicity and shape preservation, allowing for applications to long-living species in conditions of complex atmospheric flows. The scheme is connected with other parts of the model in a way that preserves the sub-grid mass distribution information that is a cornerstone of the advection algorithm. The other parts include the previously developed vertical diffusion algorithm combined with dry deposition, a meteorological pre-processor, and chemical transformation modules. The quality of the advection routine is evaluated using a large set of tests. The original approach has been previously compared with several classic algorithms widely used in operational dispersion models. The basic tests were repeated for the updated scheme and extended with real-wind simulations and demanding global 2-D tests recently suggested in the literature, which allowed one to position the scheme with regard to sophisticated state-of-the-art approaches. The advection scheme performance was fully comparable with other algorithms, with a modest computational cost. This work was the last project of Dr. Sci. Michael Galperin, who passed away on 18 March 2008.

  17. Bioengineered vascular graft with autologous stem cells: first use in the clinic. Interview with Michael Olausson.

    PubMed

    Olausson, Michael

    2012-11-01

    Michael Olausson talks to Regenerative Medicine about the pioneering clinical use of a bioengineered vascular graft to treat a 9-year-old girl with extrahepatic portal vein obstruction and the future potential of bioengineered vessels. Michael Olausson has been Professor of Transplantation Surgery at Gothenburg University (Gothenburg, Sweden) since 2000, and was Chairman of the Sahlgrenska Transplant Institute at Sahlgrenska University Hospital (Gothenburg, Sweden) between 1994 and June 2011. His scientific interests include transplant immunology and experimental and clinical transplantation studies. He has published over 240 original articles, reviews and book chapters in the field of transplantation. He has been invited as a speaker at several national and international meetings all over the world. He has pioneered several innovative surgical procedures in the Nordic countries, Europe and the rest of the world. Last year, he performed the first operation in the world using a stem cell-derived vein and recently he performed the two first mother-to-daughter live donor uterus transplantations in the world, together with a team from Gothenburg. In the past, he has been President of The Swedish Transplantation Society, and board member and Vice President of the European Liver and Intestinal Transplantation Association. In 2008 he received the Carl-Gustav Groth Scandinavian Transplant Prize. PMID:23210807

  18. A receding horizon approach for dynamic UAV mission management

    NASA Astrophysics Data System (ADS)

    Cassandras, Christos G.; Li, Wei

    2003-09-01

    We consider a setting where multiple UAVs form a team cooperating to visit multiple targets to collect rewards associated with them. The team objective is to maximize the total reward accumulated over a given time interval. Complicating factors include uncertainties regarding the locations of targets and the effectiveness of collecting rewards, differences among vehicle capabilities, and the fact that rewards are time-varying. We describe a Receding Horizon (RH) control scheme which dynamically assigns vehicles to targets and simultaneously determines associated trajectories. This scheme is based on solving a sequence of optimization problems over a planning horizon and executing them over a shorter action horizon. We also describe a simulated battlespace environment designed to test UAV team missions and to illustrate how the RH scheme can achieve optimal performance with high probability.

  19. Asymptotically Lifshitz spacetimes with universal horizons in (1 +2 ) dimensions

    NASA Astrophysics Data System (ADS)

    Basu, Sayandeb; Bhattacharyya, Jishnu; Mattingly, David; Roberson, Matthew

    2016-03-01

    Hořava gravity theory possesses global Lifshitz space as a solution and has been conjectured to provide a natural framework for Lifshitz holography. We derive the conditions on the two-derivative Hořava gravity Lagrangian that are necessary for static, asymptotically Lifshitz spacetimes with flat transverse dimensions to contain a universal horizon, which plays a similar thermodynamic role as the Killing horizon in general relativity. Specializing to z =2 in 1 +2 dimensions, we then numerically construct such regular solutions over the whole spacetime. We calculate the mass for these solutions and show that, unlike the asymptotically anti-de Sitter case, the first law applied to the universal horizon is straightforwardly compatible with a thermodynamic interpretation.

  20. Thermodynamics of event horizons in (2+1)-dimensional gravity

    SciTech Connect

    Reznik, B. )

    1992-03-15

    Although gravity in 2+1 dimensions is very different in nature from gravity in 3+1 dimensions, it is shown that the laws of thermodynamics for event horizons can be manifested also for (2+1)-dimensional gravity. The validity of the classical laws of horizon mechanics is verified in general and exemplified for the (2+1)-dimensional analogues of Reissner-Nordstroem and Schwarzschild--de Sitter spacetimes. We find that the entropy is given by 1/4{ital L}, where {ital L} is the length of the horizon. A consequence of having consistent thermodynamics is that the second law fixes the sign of Newton's constant to be positive.

  1. Black hole thermodynamics from near-horizon conformal quantum mechanics

    SciTech Connect

    Camblong, Horacio E.; Ordonez, Carlos R.

    2005-05-15

    The thermodynamics of black holes is shown to be directly induced by their near-horizon conformal invariance. This behavior is exhibited using a scalar field as a probe of the black hole gravitational background, for a general class of metrics in D spacetime dimensions (with D{>=}4). The ensuing analysis is based on conformal quantum mechanics, within a hierarchical near-horizon expansion. In particular, the leading conformal behavior provides the correct quantum statistical properties for the Bekenstein-Hawking entropy, with the near-horizon physics governing the thermodynamics from the outset. Most importantly: (i) this treatment reveals the emergence of holographic properties; (ii) the conformal coupling parameter is shown to be related to the Hawking temperature; and (iii) Schwarzschild-like coordinates, despite their 'coordinate singularity', can be used self-consistently to describe the thermodynamics of black holes.

  2. Deepwater Horizon oil spill monitoring using airborne multispectral infrared imagery

    NASA Astrophysics Data System (ADS)

    Shen, Sylvia S.; Lewis, Paul E.

    2011-06-01

    On April 28, 2010, the Environmental Protection Agency's (EPA) Airborne Spectral Photometric Environmental Collection Technology (ASPECT) aircraft was deployed to Gulfport, Mississippi to provide airborne remotely sensed air monitoring and situational awareness data and products in response to the Deepwater Horizon oil spill disaster. The ASPECT aircraft was released from service on August 9, 2010 after having flown over 85 missions that included over 325 hours of flight operation. This paper describes several advanced analysis capabilities specifically developed for the Deepwater Horizon mission to correctly locate, identify, characterize, and quantify surface oil using ASPECT's multispectral infrared data. The data products produced using these advanced analysis capabilities provided the Deepwater Horizon Incident Command with a capability that significantly increased the effectiveness of skimmer vessel oil recovery efforts directed by the U.S. Coast Guard, and were considered by the Incident Command as key situational awareness information.

  3. Priority Questions and Horizon Scanning for Conservation: A Comparative Study

    PubMed Central

    Kark, Salit; Sutherland, William J.; Shanas, Uri; Klass, Keren; Achisar, Hila; Dayan, Tamar; Gavrieli, Yael; Justo-Hanani, Ronit; Mandelik, Yael; Orion, Nir; Pargament, David; Portman, Michelle; Reisman-Berman, Orna; Safriel, Uriel N.; Schaffer, Gad; Steiner, Noa; Tauber, Israel; Levin, Noam

    2016-01-01

    Several projects aimed at identifying priority issues for conservation with high relevance to policy have recently been completed in several countries. Two major types of projects have been undertaken, aimed at identifying (i) policy-relevant questions most imperative to conservation and (ii) horizon scanning topics, defined as emerging issues that are expected to have substantial implications for biodiversity conservation and policy in the future. Here, we provide the first overview of the outcomes of biodiversity and conservation-oriented projects recently completed around the world using this framework. We also include the results of the first questions and horizon scanning project completed for a Mediterranean country. Overall, the outcomes of the different projects undertaken (at the global scale, in the UK, US, Canada, Switzerland and in Israel) were strongly correlated in terms of the proportion of questions and/or horizon scanning topics selected when comparing different topic areas. However, some major differences were found across regions. There was large variation among regions in the percentage of proactive (i.e. action and response oriented) versus descriptive (non-response oriented) priority questions and in the emphasis given to socio-political issues. Substantial differences were also found when comparing outcomes of priority questions versus horizon scanning projects undertaken for the same region. For example, issues related to climate change, human demography and marine ecosystems received higher priority as horizon scanning topics, while ecosystem services were more emphasized as current priority questions. We suggest that future initiatives aimed at identifying priority conservation questions and horizon scanning topics should allow simultaneous identification of both current and future priority issues, as presented here for the first time. We propose that further emphasis on social-political issues should be explicitly integrated into future

  4. Priority Questions and Horizon Scanning for Conservation: A Comparative Study.

    PubMed

    Kark, Salit; Sutherland, William J; Shanas, Uri; Klass, Keren; Achisar, Hila; Dayan, Tamar; Gavrieli, Yael; Justo-Hanani, Ronit; Mandelik, Yael; Orion, Nir; Pargament, David; Portman, Michelle; Reisman-Berman, Orna; Safriel, Uriel N; Schaffer, Gad; Steiner, Noa; Tauber, Israel; Levin, Noam

    2016-01-01

    Several projects aimed at identifying priority issues for conservation with high relevance to policy have recently been completed in several countries. Two major types of projects have been undertaken, aimed at identifying (i) policy-relevant questions most imperative to conservation and (ii) horizon scanning topics, defined as emerging issues that are expected to have substantial implications for biodiversity conservation and policy in the future. Here, we provide the first overview of the outcomes of biodiversity and conservation-oriented projects recently completed around the world using this framework. We also include the results of the first questions and horizon scanning project completed for a Mediterranean country. Overall, the outcomes of the different projects undertaken (at the global scale, in the UK, US, Canada, Switzerland and in Israel) were strongly correlated in terms of the proportion of questions and/or horizon scanning topics selected when comparing different topic areas. However, some major differences were found across regions. There was large variation among regions in the percentage of proactive (i.e. action and response oriented) versus descriptive (non-response oriented) priority questions and in the emphasis given to socio-political issues. Substantial differences were also found when comparing outcomes of priority questions versus horizon scanning projects undertaken for the same region. For example, issues related to climate change, human demography and marine ecosystems received higher priority as horizon scanning topics, while ecosystem services were more emphasized as current priority questions. We suggest that future initiatives aimed at identifying priority conservation questions and horizon scanning topics should allow simultaneous identification of both current and future priority issues, as presented here for the first time. We propose that further emphasis on social-political issues should be explicitly integrated into future

  5. Genome walking.

    PubMed

    Shapter, Frances M; Waters, Daniel L E

    2014-01-01

    Genome walking is a method for determining the DNA sequence of unknown genomic regions flanking a region of known DNA sequence. The Genome walking has the potential to capture 6-7 kb of sequence in a single round. Ideal for identifying gene promoter regions where only the coding region. Genome walking also has significant utility for capturing homologous genes in new species when there are areas in the target gene with strong sequence conservation to the characterized species. The increasing use of next-generation sequencing technologies will see the principles of genome walking adapted to in silico methods. However, for smaller projects, PCR-based genome walking will remain an efficient method of characterizing unknown flanking sequence. PMID:24243201

  6. A Horizon Scan of Global Conservation Issues for 2016.

    PubMed

    Sutherland, William J; Broad, Steven; Caine, Jacqueline; Clout, Mick; Dicks, Lynn V; Doran, Helen; Entwistle, Abigail C; Fleishman, Erica; Gibbons, David W; Keim, Brandon; LeAnstey, Becky; Lickorish, Fiona A; Markillie, Paul; Monk, Kathryn A; Mortimer, Diana; Ockendon, Nancy; Pearce-Higgins, James W; Peck, Lloyd S; Pretty, Jules; Rockström, Johan; Spalding, Mark D; Tonneijck, Femke H; Wintle, Bonnie C; Wright, Katherine E

    2016-01-01

    This paper presents the results of our seventh annual horizon scan, in which we aimed to identify issues that could have substantial effects on global biological diversity in the future, but are not currently widely well known or understood within the conservation community. Fifteen issues were identified by a team that included researchers, practitioners, professional horizon scanners, and journalists. The topics include use of managed bees as transporters of biological control agents, artificial superintelligence, electric pulse trawling, testosterone in the aquatic environment, building artificial oceanic islands, and the incorporation of ecological civilization principles into government policies in China. PMID:26688445

  7. Near-horizon solution for Dvali-Gabadadze-Porrati perturbations

    SciTech Connect

    Sawicki, Ignacy; Song, Yong-Seon; Hu, Wayne

    2007-03-15

    We develop a scaling ansatz for the master equation in Dvali, Gabadadze, Porrati cosmologies, which allows us to solve the equations of motion for perturbations off the brane during periods when the on-brane evolution is scale free. This allows us to understand the behavior of the gravitational potentials outside the horizon at high redshifts and close to the horizon today. We confirm that the results of Koyama and Maartens are valid at scales relevant for observations such as galaxy-ISW correlations. At larger scales, there is an additional suppression of the potential which reduces the growth rate even further and would strengthen the integrated Sachs-Wolf effect.

  8. Earth, Meet Pluto: The New Horizons Education and Communications Partnership

    NASA Astrophysics Data System (ADS)

    Buckley, M.

    2015-12-01

    The unique partnership between the NASA New Horizons education/communications and public affairs programs tapped into the excitement of visiting an unexplored planet in a new region of the solar system - resulting in unprecedented public participation in and coverage of a planetary mission. With a range of hands-on learning experiences, Web materials and online , the program provided opportunities for students, educators, museums, science centers, the media, Web surfers and other members of the public to ride along on the first mission to Pluto and the Kuiper Belt. The programs leveraged resources, materials and expertise to address a wide range of traditional and nontraditional audiences while providing consistent messages and information on this historic NASA endeavor. The E/C program included a variety of formal lesson plans and learning materials — based on New Horizons science and engineering goals, and aligned with National Research Council's National Science Education Standards — that continue to help students in grades K-12 learn more about science, technology, engineering and mathematics. College students designed and built an actual flight instrument on New Horizons and held internships with the spacecraft integration and test team. New Horizons E/C programs went well beyond the classroom, from a chance for people to send their names to Pluto on board the New Horizons spacecraft before launch, to opportunities for the public to access milestone events and the first-ever close-up views of Pluto in places such as museums, science centers and libraries, TV and the Web — as well as thousands who attended interactive "Plutopalooza" road shows across the country. Teamed with E/C was the public affairs strategy to communicate New Horizons news and messages to media, mission stakeholders, the scientific community and the public. These messages include various aspects of New Horizons, including the progress of the mission and key milestones and achievements

  9. A horizon scan of global conservation issues for 2014.

    PubMed

    Sutherland, William J; Aveling, Rosalind; Brooks, Thomas M; Clout, Mick; Dicks, Lynn V; Fellman, Liz; Fleishman, Erica; Gibbons, David W; Keim, Brandon; Lickorish, Fiona; Monk, Kathryn A; Mortimer, Diana; Peck, Lloyd S; Pretty, Jules; Rockström, Johan; Rodríguez, Jon Paul; Smith, Rebecca K; Spalding, Mark D; Tonneijck, Femke H; Watkinson, Andrew R

    2014-01-01

    This paper presents the output of our fifth annual horizon-scanning exercise, which aims to identify topics that increasingly may affect conservation of biological diversity, but have yet to be widely considered. A team of professional horizon scanners, researchers, practitioners, and a journalist identified 15 topics which were identified via an iterative, Delphi-like process. The 15 topics include a carbon market induced financial crash, rapid geographic expansion of macroalgal cultivation, genetic control of invasive species, probiotic therapy for amphibians, and an emerging snake fungal disease. PMID:24332318

  10. A horizon scan of global conservation issues for 2014

    PubMed Central

    Sutherland, William J.; Aveling, Rosalind; Brooks, Thomas M.; Clout, Mick; Dicks, Lynn V.; Fellman, Liz; Fleishman, Erica; Gibbons, David W.; Keim, Brandon; Lickorish, Fiona; Monk, Kathryn A.; Mortimer, Diana; Peck, Lloyd S.; Pretty, Jules; Rockström, Johan; Rodríguez, Jon Paul; Smith, Rebecca K.; Spalding, Mark D.; Tonneijck, Femke H.; Watkinson, Andrew R.

    2014-01-01

    This paper presents the output of our fifth annual horizon-scanning exercise, which aims to identify topics that increasingly may affect conservation of biological diversity, but have yet to be widely considered. A team of professional horizon scanners, researchers, practitioners, and a journalist identified 15 topics which were identified via an iterative, Delphi-like process. The 15 topics include a carbon market induced financial crash, rapid geographic expansion of macroalgal cultivation, genetic control of invasive species, probiotic therapy for amphibians, and an emerging snake fungal disease. PMID:24332318

  11. Robust Consumption-Investment Problem on Infinite Horizon

    SciTech Connect

    Zawisza, Dariusz

    2015-12-15

    In our paper we consider an infinite horizon consumption-investment problem under a model misspecification in a general stochastic factor model. We formulate the problem as a stochastic game and finally characterize the saddle point and the value function of that game using an ODE of semilinear type, for which we provide a proof of an existence and uniqueness theorem for its solution. Such equation is interested on its own right, since it generalizes many other equations arising in various infinite horizon optimization problems.

  12. Prophage Genomics

    PubMed Central

    Canchaya, Carlos; Proux, Caroline; Fournous, Ghislain; Bruttin, Anne; Brüssow, Harald

    2003-01-01

    The majority of the bacterial genome sequences deposited in the National Center for Biotechnology Information database contain prophage sequences. Analysis of the prophages suggested that after being integrated into bacterial genomes, they undergo a complex decay process consisting of inactivating point mutations, genome rearrangements, modular exchanges, invasion by further mobile DNA elements, and massive DNA deletion. We review the technical difficulties in defining such altered prophage sequences in bacterial genomes and discuss theoretical frameworks for the phage-bacterium interaction at the genomic level. The published genome sequences from three groups of eubacteria (low- and high-G+C gram-positive bacteria and γ-proteobacteria) were screened for prophage sequences. The prophages from Streptococcus pyogenes served as test case for theoretical predictions of the role of prophages in the evolution of pathogenic bacteria. The genomes from further human, animal, and plant pathogens, as well as commensal and free-living bacteria, were included in the analysis to see whether the same principles of prophage genomics apply for bacteria living in different ecological niches and coming from distinct phylogenetical affinities. The effect of selection pressure on the host bacterium is apparently an important force shaping the prophage genomes in low-G+C gram-positive bacteria and γ-proteobacteria. PMID:12794192

  13. Through the looking glass: why the `cosmic horizon' is not a horizon

    NASA Astrophysics Data System (ADS)

    van Oirschot, Pim; Kwan, Juliana; Lewis, Geraint F.

    2010-06-01

    The present standard model of cosmology, Λ cold dark matter (ΛCDM), contains some intriguing coincidences. Not only are the dominant contributions to the energy density approximately of the same order at the present epoch, but we also note that contrary to the emergence of cosmic acceleration as a recent phenomenon, the time-averaged value of the deceleration parameter over the age of the Universe is nearly zero. Curious features like these in ΛCDM give rise to a number of alternate cosmologies being proposed to remove them, including models with an equation of state w = -1/3. In this paper, we examine the validity of some of these alternate models and we also address some persistent misconceptions about the Hubble sphere and the event horizon that lead to erroneous conclusions about cosmology. Research undertaken as part of the Commonwealth Cosmology Initiative (CCI: http://www.thecci.org), an international collaboration supported by the Australian Research Council. E-mail: pimvanoirschot@gmail.com

  14. Enantioselective Phase-Transfer-Catalyzed Synthesis of Chiral N-Substituted 3,3-Dinitroazetidines by Aza-Michael Reaction.

    PubMed

    Lee, Hyo-Jun; Cho, Chang-Woo

    2015-11-20

    An efficient and highly enantioselective phase-transfer-catalyzed aza-Michael reaction of 3,3-dinitroazetidine, as N-centered nucleophile, to α,β-unsaturated ketones has been achieved using a quinidine-based phase-transfer catalyst (0.5-1 mol %), providing chiral N-substituted 3,3-dinitroazetidines in good yields (up to 99%) and excellent enantioselectivities (90-95% ee). This is the first example of the use of azetidines as N-centered nucleophiles in catalytic enantioselective aza-Michael reactions. PMID:26503134

  15. Isoindolinones as Michael Donors under Phase Transfer Catalysis: Enantioselective Synthesis of Phthalimidines Containing a Tetrasubstituted Carbon Stereocenter.

    PubMed

    Scorzelli, Francesco; Di Mola, Antonia; Palombi, Laura; Massa, Antonio

    2015-01-01

    Readily available chiral ammonium salts derived from cinchona alkaloids have proven to be effective phase transfer catalysts in the asymmetric Michael reaction of 3-substituted isoindolinones. This protocol provides a convenient method for the construction of valuable asymmetric 3,3-disubstituted isoindolinones in high yields and  moderate to good enantioselectivity. Diastereoselectivity was also investigated in the construction of contiguous tertiary and quaternary stereocenters. The use of acrolein as Michael acceptor led to an interesting tricyclic derivative, a pyrroloisoindolinone analogue, via a tandem conjugated addition/cyclization reaction. PMID:25985353

  16. Higher Horizons: An Evaluation of an Expanded Team Program.

    ERIC Educational Resources Information Center

    Hartford Public Schools, CT.

    The original Higher Horizons Program or HH 100, was established in 1965 as a ninth grade compensatory model which could be used to demonstrate that some of the more salient ravages of educational deprivation could be corrected effectively, and at the high school level. So as to demonstrate that secondary school compensatory education could…

  17. Knowledge Concerning the Mathematical Horizon: A Close View

    ERIC Educational Resources Information Center

    Guberman, Raisa; Gorev, Dvora

    2015-01-01

    The main objective of this study is to identify components of teachers' mathematical knowledge for teaching, associated with the knowledge of mathematical horizon (KMH) in order to describe this type of knowledge from the viewpoint of elementary school mathematics teachers. The research population of this study consisted of 118 elementary school…

  18. Solution to the cosmological horizon problem proposed by Zee

    SciTech Connect

    Pollock, M.D.

    1981-08-15

    Applying a theory of gravity with broken symmetry, Zee has suggested a solution to the cosmological horizon problem. His idea has been criticized on two independent grounds by Linde and by Sato. In this paper, we suggest answers to both these criticisms.

  19. New Horizons: An Empowerment Program for Egyptian Adolescent Girls.

    ERIC Educational Resources Information Center

    Swanson, Julie Hanson

    New Horizons is a nonschool program that demystifies and communicates essential information on basic life skills and reproductive health to Egyptian girls and young women aged 9-20. The program consists of 100 hour-long sessions, each including an introduction to a specific topic, review of group knowledge level, discussion around key points…

  20. Community Colleges Broadening Horizons through Service Learning, 2006-2009

    ERIC Educational Resources Information Center

    Robinson, Gail

    2007-01-01

    This brief introduces "Community Colleges Broadening Horizons through Service Learning," the American Association of Community Colleges' (AACC's) fifth national Learn and Serve America grant project and describes its grantee college programs. The goals of this grant project are to build on established foundations to integrate service learning…

  1. Breaking an Abelian gauge symmetry near a black hole horizon

    SciTech Connect

    Gubser, Steven S.

    2008-09-15

    I argue that coupling the Abelian Higgs model to gravity plus a negative cosmological constant leads to black holes which spontaneously break the gauge invariance via a charged scalar condensate slightly outside their horizon. This suggests that black holes can superconduct.

  2. Colorful Horizons with Charge in Anti-de Sitter Space

    SciTech Connect

    Gubser, Steven S.

    2008-11-07

    An Abelian gauge symmetry can be spontaneously broken near a black hole horizon in anti-de Sitter space using a condensate of non-Abelian gauge fields. A second order phase transition is shown to separate Reissner-Nordstroem-anti-de Sitter solutions from a family of symmetry-breaking solutions which preserve a diagonal combination of gauge invariance and spatial rotational invariance.

  3. New Horizons for Learning: An Interview with Dee Dickinson

    ERIC Educational Resources Information Center

    Windham, Scott; Dickinson, Dee

    2005-01-01

    This article presents an interview with Dee Dickinson, founder and chief learning officer of New Horizons for Learning, a nonprofit international education network whose mission is to identify, communicate, and help implement effective teaching and learning strategies. Founded in 1980 and now operating largely through its Web site, New Horizons…

  4. Apparent horizons in D-dimensional Robinson-Trautman spacetime

    SciTech Connect

    Svitek, Otakar

    2009-05-01

    We derive the higher dimensional generalization of Penrose-Tod equation describing apparent horizons in Robinson-Trautman spacetimes. New results concerning the existence and uniqueness of its solutions in four dimensions are proven. Namely, previous results of Tod [1] are generalized to nonvanishing cosmological constant.

  5. 7. PHOTOGRAPHIC COPY OF ORIGINAL CONSTRUCTION DRAWING, DATED 1918, HORIZONAL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. PHOTOGRAPHIC COPY OF ORIGINAL CONSTRUCTION DRAWING, DATED 1918, HORIZONAL SLIDING WINDOW DETAIL, WAR DEPARTMENT, MANUAL OF THE CONSTRUCTION DIVISION OF THE ARMY, WAR EMERGENCY CONSTRUCTION, SECTION C, ENGINEERING DIVISION, PLATE 5, CONSOLIDATED SUPPLY COMPANY PRINTERS, WASHINGTON - Fort Bliss, 7th Cavalry Buildings, U.S. Army Air Defence Artillery Center & Fort Bliss, El Paso, El Paso County, TX

  6. SOLUBLE ALUMINUM IN ACIDIFIED ORGANIC HORIZONS OF FOREST SOILS

    EPA Science Inventory

    Concentrations of labile and total Al in soil extracts were measured as a function of equilibrium solution pH in six forest soil organic horizons acidified with HNO, (0-20 cmol H+.kg-1) under controlled conditions of ionic strength (0.05 M NaNO3), temperature (23 C), and solution...

  7. The high water-holding capacity of petrocalcic horizons

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Petrocalcic soil horizons occur in most arid and semi-arid ecosystems around the world, often within the plant rooting zone. Little is known, however, about the water holding characteristic of soils indurated with calcium carbonate. We conducted a replicated experiment to define the soil-water relea...

  8. Star/horizon simulator used to test space guidance system

    NASA Technical Reports Server (NTRS)

    Schmidt, W. C.

    1967-01-01

    Star/horizon simulator is used for alignment and optical plus photoelectric tests of the sextant for the Apollo guidance and navigation system optical unit assembly. The unit is basically a refractive collimator with a two inch objective lens system and a twenty-four inch focal length.

  9. Black Hole Physics with the Event Horizon Telescope

    NASA Astrophysics Data System (ADS)

    Ozel, Feryal

    2016-01-01

    The Event Horizon Telescope is an experiment that is being performed on a large and ever-increasing array of radio telescopes that span the Earth from Hawaii to Chile and from the South Pole to Arizona. When data will be taken with the full array, it will image the event horizons of the supermassive black hole at the center of our Galaxy, Sagittarius A*, and the black hole at the center of M87, with an unprecedented 10 microarcssecond resolution. This will allow us to take the first ever pictures of black holes at 1.3 and 0.85 mm wavelengths and look for the shadow that is a direct evidence for a black hole predicted by the theory of General Relativity. In addition, the Event Horizon Telescope will also enable us to study the process by which black holes accrete matter and grow in mass. I will discuss the theoretical developments in simulating the properties of the black hole accretion flows and their expected images using state-of-the-art algorithms and high performance computing. Interpreting the upcoming observations within this theoretical framework will open new horizons in black hole astrophysics.

  10. Ecological Impacts of the Deepwater Horizon Oil Spill (Bogota, Columbia)

    EPA Science Inventory

    The Deepwater Horizon oil spill (DWH) was the largest environmental disaster and response effort in US History, with nearly 800 million liters spilled. Vast areas of the Gulf of Mexico were contaminated with oil, including deep ocean communities, protected species, over 1600 km o...

  11. Survey of New Horizons International Music Association Musicians

    ERIC Educational Resources Information Center

    Coffman, Don

    2009-01-01

    This study analysed survey responses from 1652 New Horizons International Music Association (NHIMA) musicians in the United States and Canada to better understand older adults' experiences in making music. The purpose of this study was threefold: (a) ascertain the extent of NHIMA musicians' musical backgrounds and their current involvement in…

  12. Ecological impacts of the Deepwater Horizon oil spill

    EPA Science Inventory

    The Deepwater Horizon oil spill (DWH) was the largest environmental disaster and response effort in United States history, with nearly 800 million liters of crude oil spilled. Vast areas of the Gulf of Mexico were contaminated with oil, including deep ocean communities and over 1...

  13. Ecological Impacts during the Deepwater Horizon Oil Spill

    EPA Science Inventory

    The Deepwater Horizon (DWH) oil spill was the largest spill and response effort in United States history. Nearly 800 million L of oil was spilled in the Gulf of Mexico, and nearly 7 million L of chemical dispersants were applied in at the ocean surface and subsea1. The DWH spill ...

  14. A MIP Model for Rolling Horizon Surgery Scheduling.

    PubMed

    Luo, Li; Luo, Yong; You, Yang; Cheng, Yuanjun; Shi, Yingkang; Gong, Renrong

    2016-05-01

    Most surgery scheduling is done 1 day in advance. Caused by lack of overall planning, this scheduling scheme often results in unbalanced occupancy time of the operating rooms. So we put forward a rolling horizon mixed integer programming model for the scheduling. Rolling horizon scheduling refers to a scheduling scheme in which cyclic surgical requests are taken into account. Surgical requests are updated daily. The completed surgeries are eliminated, and new surgeries are added to the scheduling list. Considering day-to-day demand for surgery, we develop a non-rolling scheduling model (NRSM) and a rolling horizon scheduling model (RSM). By comparing the two, we find that the quality of surgery scheduling is significantly influenced by the variation in demand from day to day. A rolling horizon scheduling will enable a more flexible planning of the pool of surgeries that have not been scheduled into this main blocks, and hence minimize the idle time of operating rooms. The strategy of the RSM helps balance the occupancy time among operating rooms. Using surgical data from five departments of the West China Hospital (WCH), we generate surgical demands randomly to compare the NRSM and the RSM. The results show the operating rooms' average utilization rate using RSM is significantly higher than when applying NRSM. PMID:27071394

  15. How Big Is the Earth? A Calculation beyond Your Horizon

    ERIC Educational Resources Information Center

    Kibble, Bob

    2011-01-01

    A consequence of the curvature of the Earth is that distant ships apparently disappear over the horizon. This article shows how you can use a simple photograph to help students obtain a reasonable estimate of the size of the Earth using little more than the mathematics of Pythagoras. (Contains 5 figures.)

  16. Gravitational black hole hair from event horizon supertranslations

    NASA Astrophysics Data System (ADS)

    Averin, Artem; Dvali, Gia; Gomez, Cesar; Lüst, Dieter

    2016-06-01

    We discuss BMS supertranslations both at null-infinity BMS- and on the horizon {BMS}^{mathscr{H}} for the case of the Schwarzschild black hole. We show that both kinds of supertranslations lead to infinetly many gapless physical excitations. On this basis we construct a quotient algebra mathcal{A}equiv {BMS}^{mathscr{H}}/{BMS}- using suited superpositions of both kinds of transformations which cannot be compensated by an ordinary BMS-supertranslation and therefore are intrinsically due to the presence of an event horizon. We show that transformations in mathcal{A} are physical and generate gapless excitations on the horizon that can account for the gravitational hair as well as for the black hole entropy. We identify the physics of these modes as associated with Bogolioubov-Goldstone modes due to quantum criticality. Classically the number of these gapless modes is infinite. However, we show that due to quantum criticality the actual amount of information-carriers becomes finite and consistent with Bekenstein entropy. Although we only consider the case of Schwarzschild geometry, the arguments are extendable to arbitrary space-times containing event horizons.

  17. The Horizon Project Call to Scholarship: 2007-8

    ERIC Educational Resources Information Center

    New Media Consortium, 2007

    2007-01-01

    With the release of the fourth edition in the annual "Horizon Report, the New Media Consortium (NMC) has undertaken a concerted, international effort to describe a research agenda and call to scholarship based on the six practices and technologies featured in the report. The community was invited to participate in this process, contribute to the…

  18. CFT/gravity correspondence on the isolated horizon

    NASA Astrophysics Data System (ADS)

    Ghosh, Amit; Pranzetti, Daniele

    2014-12-01

    A quantum isolated horizon can be modelled by an SU (2) Chern-Simons theory on a punctured 2-sphere. We show how a local 2-dimensional conformal symmetry arises at each puncture inducing an infinite set of new observables localised at the horizon which satisfy a Kac-Moody algebra. By means of the isolated horizon boundary conditions, we represent the gravitational flux degrees of freedom in terms of the zero modes of the Kac-Moody algebra defined on the boundary of a punctured disk. In this way, our construction encodes a precise notion of CFT/gravity correspondence. The higher modes in the algebra represent new nongeometric charges which can be represented in terms of free matter field degrees of freedom. When computing the CFT partition function of the system, these new states induce an extra degeneracy factor, representing the density of horizon states at a given energy level, which reproduces the Bekenstein's holographic bound for an imaginary Immirzi parameter. This allows us to recover the Bekenstein-Hawking entropy formula without the large quantum gravity corrections associated with the number of punctures.

  19. Rethinking Classroom Management: A New Perspective, a New Horizon

    ERIC Educational Resources Information Center

    Toprakci, Erdal

    2012-01-01

    The purpose of this study is to suggest a new perspective and a new horizon by analyzing the concept of classroom management in the literature of traditional classroom management from a scientific and dictionary view. It may be said that there are serious problems regarding the settlement of the meaning of "classroom management" in the educational…

  20. Physics from the News: The Deepwater Horizon Disaster

    NASA Astrophysics Data System (ADS)

    Bartlett, Albert

    2010-10-01

    A surprising (at least to me) phenomenon from hydrostatics may have played a role in initiating the blowout and fire (April 20, 2010) that burned for two days before sinking the drilling ship the Deepwater Horizon, resulting in a large and environmentally destructive oil spill in the Gulf of Mexico.

  1. Ecological Impacts During the Deepwater Horizon Oil Spill Response

    EPA Science Inventory

    The Deepwater Horizon (DWH) oil spill was the largest environmental disaster and response effort in U.S. history, with nearly 800 million liters of crude oil spilled. Vast areas of the Gulf of Mexico were contaminated with oil, including deep-ocean communities and over 1,600 kilo...

  2. Reconstructing metabolic pathways of hydrocarbon-degrading bacteria from the Deepwater Horizon oil spill.

    PubMed

    Dombrowski, Nina; Donaho, John A; Gutierrez, Tony; Seitz, Kiley W; Teske, Andreas P; Baker, Brett J

    2016-01-01

    The Deepwater Horizon blowout in the Gulf of Mexico in 2010, one of the largest marine oil spills(1), changed bacterial communities in the water column and sediment as they responded to complex hydrocarbon mixtures(2-4). Shifts in community composition have been correlated to the microbial degradation and use of hydrocarbons(2,5,6), but the full genetic potential and taxon-specific metabolisms of bacterial hydrocarbon degraders remain unresolved. Here, we have reconstructed draft genomes of marine bacteria enriched from sea surface and deep plume waters of the spill that assimilate alkane and polycyclic aromatic hydrocarbons during stable-isotope probing experiments, and we identify genes of hydrocarbon degradation pathways. Alkane degradation genes were ubiquitous in the assembled genomes. Marinobacter was enriched with n-hexadecane, and uncultured Alpha- and Gammaproteobacteria populations were enriched in the polycyclic-aromatic-hydrocarbon-degrading communities and contained a broad gene set for degrading phenanthrene and naphthalene. The repertoire of polycyclic aromatic hydrocarbon use varied among different bacterial taxa and the combined capabilities of the microbial community exceeded those of its individual components, indicating that the degradation of complex hydrocarbon mixtures requires the non-redundant capabilities of a complex oil-degrading community. PMID:27572965

  3. Aquaculture Genomics

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The genomics chapter covers the basics of genome mapping and sequencing and the current status of several relevant species. The chapter briefly describes the development and use of (cDNA, BAC, etc.) libraries for mapping and obtaining specific sequence information. Other topics include comparative ...

  4. What happens to Petrov classification, on horizons of axisymmetric dirty black holes

    SciTech Connect

    Tanatarov, I. V.; Zaslavskii, O. B.

    2014-02-15

    We consider axisymmetric stationary dirty black holes with regular non-extremal or extremal horizons, and compute their on-horizon Petrov types. The Petrov type (PT) in the frame of the observer crossing the horizon can be different from that formally obtained in the usual (but singular in the horizon limit) frame of an observer on a circular orbit. We call this entity the boosted Petrov type (BPT), as the corresponding frame is obtained by a singular boost from the regular one. The PT off-horizon can be more general than PT on-horizon and that can be more general than the BPT on horizon. This is valid for all regular metrics, irrespective of the extremality of the horizon. We analyze and classify the possible relations between the three characteristics and discuss the nature and features of the underlying singular boost. The three Petrov types can be the same only for space-times of PT D and O off-horizon. The mutual alignment of principal null directions and the generator in the vicinity of the horizon is studied in detail. As an example, we also analyze a special class of metrics with utra-extremal horizons (for which the regularity conditions look different from the general case) and compare their off-horizon and on-horizon algebraic structure in both frames.

  5. New Horizons: Bridge to the Beginning - to Pluto and Beyond

    NASA Astrophysics Data System (ADS)

    Weir, H. M.; Hallau, K. G.; Seaton, P.; Beisser, K.; New Horizons Education; Public Outreach Team

    2010-12-01

    Launched on Jan. 19, 2006, NASA’s New Horizons mission to Pluto and the Kuiper Belt will help us understand worlds at the edge of our solar system by making the first reconnaissance of Pluto and Charon - a "double planet" and the last planet in our solar system to be visited by spacecraft. However, New Horizons’ closest approach to Pluto will not occur until July 14, 2015, and the majority of the craft's time over the next 5 years will be spent in "hibernation." The Education and Public Outreach (EPO) team, however, will not be hibernating as we wait for New Horizons to reach its destination. With three distinct tools-- Educator Fellows, online learning modules and a planetarium program--the team seeks to excite and engage teachers, students and the public with information about the journey to Pluto and beyond. In the past year, the specially selected educators who participate as New Horizons Educator Fellows have trained more than 1,000 teachers across the U.S. on the New Horizons mission and the science behind it. Thousands more students, parents, educators, and citizens have learned about New Horizons from the mission's scientists, engineers and outreach professionals. New Horizons Fellows also distribute another EPO tool: online learning modules. These classroom-ready learning modules consist of educator guides, student handouts, detailed activities, and potential adaptations for students with special needs or disabilities. Some also offer online interactives to convey complex and dynamic concepts. The modules are web-accessible for both students and teachers, and are aligned with relevant national standards. The third tool is a highly visual way to engage the general public and supplement educational programs: a planetarium program that highlights the New Horizons mission from launch to destination Pluto. This program focuses on the engineering design of the spacecraft, with a focus on the concept of the electromagnetic spectrum. In the unique environment

  6. Volcanic resurfacing of Io between Galileo and New Horizons Observations

    NASA Astrophysics Data System (ADS)

    Coman, E.; Phillips, C. B.

    2011-12-01

    Io is the most geologically active object in our solar system. Due to its tumultuous volcanism, determining Io's resurfacing rate will allow better characterization of the subsurface structure, thermal state, and history of tidal heating of this small moon. Numerous active volcanic centers were documented during the Galileo mission in the late 1990's and early 2000's, and the opportunity to discover more of these centers was presented with the flyby of New Horizons in 2007. Previous authors (i.e. Spencer et al. 2007) have compared Galileo SSI and New Horizons LORRI images with similar viewing geometry, and have found multiple new potential features such as dark lava flows and bright plume deposits emplaced between the two flybys. The purpose of this study was to measure the extent of these changes on Io. Because an ISIS camera model does not yet exist for LORRI, a direct ratio image for comparison with the Galileo SSI images could not be created. By changing the stretch of the Galileo SSI images to match those of New Horizons as closely as possible, we were able to create a rough ratio image for the active center locations. We used these ratio images to measure the areal extent of the new deposits, taking careful precautions to measure more changes in shape than brightness, as brightness variations can be caused by certain surface materials being viewed at different phase angles between the Galileo and New Horizons flybys. This presentation will report our measurement findings. We then are able to use our measurements of the total area covered by new volcanic features to make estimates of the resurfacing rate of Io. Spencer, J.R. et al. (2007), Io Volcanism Seen by New Horizons: A Major Eruption of the Tvashtar Volcano, Science, 318, 240, DOI:10.1126/science.1147621.

  7. Michael Reaction of 3-aAryl-2,4-Dicarboethoxy-5-Hydroxy-5-Methylcyclohexanones

    PubMed Central

    El-Ablack, Fawzia Zakaria; Metwally, M. A.; Khalil, A. M.

    2015-01-01

    Summary The reaction of 3-aryl-2,4-dicarboethoxy-5-hydroxy-5-methylcyclohexanones 1with benzalacetone, dibenzalacetone, benzalacetophenone, and 4-benzal-1-phenyl-3-methyl pyrazolone has been investigated to give Michael compounds 2-5. hydrolysis of the dioxo derivative 4 afforded1,5-dicarbonyl derivative 6which On condensation with hydrazine and/or substituted hydrazine and hydroxylamine produced1,2-diazepine and 1,2-oxazepine derivatives 7,8 respectively. Reaction of β-Keto ester 1 with 1,3-diphenylacetone afforded 9. The structures of the hitherto unknown compounds have been confirmed by analytical and spectral data. The newly synthesized compounds have been screened to test their antimicrobial and antifungal activity. PMID:26689538

  8. Michael Faraday on the Learning of Science and Attitudes of Mind

    NASA Astrophysics Data System (ADS)

    Crawford, Elspeth

    The paper makes use of Michael Faraday's ideas about learning, in particular his thoughts about attitudes to the unknowns of science and the development of an attitude which improves scientific decision-making. An invented scenario involving nursery school children demonstrates some attitudes displayed there. Discussion of the scenario and variation in possible outcomes suggests that Faraday's views are relevant to scientific learning in general. The main thesis of the paper is that it is central to learning in science to acknowledge that there is an inner struggle involved in facing unknowns, and that empathy with the fears and expectations of learners is an essential quality if genuinely scientific thought is to develop. It is suggested, following Faraday, that understanding our own feelings while we teach is a pre-requisite to enabling such empathy and that only then will we be in a position to evaluate accurately whether or not our pupils are thinking scientifically.

  9. Michael Fordham and the Journal of Analytical Psychology: the view from Hangman's Hill.

    PubMed

    Urban, Elizabeth

    2015-09-01

    This short paper was presented to a conference in honour of the 60(th) year of the JAP and was one of others that acknowledged the contribution of Michael Fordham. The subtitle refers to the paper's overview of Fordham's published oeuvre and the particular place of the Journal of Analytical Psychology, for which he was the founding editor. Fordham's contribution to a Jungian-based model of development is discussed, with reference to his papers in the British Journal of Medical Psychology. The paper notes miscellaneous pieces from Fordham's commentaries, obituaries, papers and reviews which capture not only the development of Fordham as a thinker but also his character. There is discussion of his reviews of Melanie Klein's Envy and Gratitude and manuscripts by Erich Neumann. A reminiscence of Fordham as supervisor is recounted. PMID:26274849

  10. Phospha-Michael Addition as a New Click Reaction for Protein Functionalization.

    PubMed

    Lee, Yan-Jiun; Kurra, Yadagiri; Liu, Wenshe R

    2016-03-15

    A new type of click reaction between an alkyl phosphine and acrylamide was developed and applied for site-specific protein labeling in vitro and in live cells. Acrylamide is a small electrophilic olefin that readily undergoes phospha-Michael addition with an alkyl phosphine. Our kinetic study indicated a second-order rate constant of 0.07 m(-1)  s(-1) for the reaction between tris(2-carboxyethyl)phosphine and acrylamide at pH 7.4. To demonstrate its application in protein functionalization, we used a dansyl-phosphine conjugate to successfully label proteins that were site-specifically installed with N(ɛ) -acryloyl-l-lysine and employed a biotin-phosphine conjugate to selectively probe human proteins that were metabolically labeled with N-acryloyl-galactosamine. PMID:26756316

  11. A double diastereoselective Michael-type addition as an entry to conformationally restricted tn antigen mimics.

    PubMed

    Aydillo, Carlos; Navo, Claudio D; Busto, Jesús H; Corzana, Francisco; Zurbano, María M; Avenoza, Alberto; Peregrina, Jesús M

    2013-11-01

    A totally stereocontrolled C-Michael addition of serine-equivalent C-nucleophiles to tri-O-benzyl-2-nitro-d-galactal was used as the key step to synthesize several pyrano[3,2-b]pyrrole structures. These scaffolds could be regarded as conformationally restricted Tn antigen mimics, as we have demonstrated by biological assays. The pyranose rings retain their (4)C1 chair conformation, as shown by molecular modeling and NMR spectroscopy. The expected bioactivity was established by a competition-tailored enzyme-linked lectin assay using both soybean and Vicia villosa agglutinins as model lectins. The facile described synthetic route and the strategic combination of computational and experimental techniques to reveal conformational features and bioactivity demonstrate the prepared glycomimics to be promising candidates for further exploitation of this scaffold to give glycans for lectin blocking and vaccination. PMID:24083620

  12. The spirituality of feeling: An interview with Michael Jawer. Interview by Nancy Nachman-Hunt.

    PubMed

    Jawer, Michael

    2009-01-01

    Michael Jawer is coauthor of The Spiritual Anatomy of Emotion (Park Street Press, 2009) and has written extensively on a variety of subjects for trade and professional associations and for the US government. Jawer has spent the past decade exploring the physiological underpinnings of feeling, how it may underlie consciousness, how various individuals process feelings, and whether that processing plays a role in psychosomatic conditions such as migraine headaches, synesthesia, chronic fatigue, and posttraumatic stress disorder (PTSD). Mr Jawer's collaborator and medical editor is Marc Micozzi, MD, PhD, adjunct professor of physiology and biophysics at the Georgetown University School of Medicine, Washington DC, and editor of the first US textbook devoted to complementary medicine, Fundamentals of Complementary and Alternative Medicine (Elsevier, 1996). PMID:20671331

  13. Science against modernism: the relevance of the social theory of Michael Polanyi.

    PubMed

    Thorpe, C

    2001-03-01

    Science, as an institution, is widely taken by sociologists to exemplify the modern tendency towards vesting trust and authority in impersonal offices and procedures, rather than in embodied human individuals. Such views of science face an important challenge in the social philosophy of Michael Polanyi. His work provides important insights into the continuing role of embodied personal authority and tradition in science and, hence, in late modernity. I explicate Polanyi's relevance for social theory, through a comparison with Weber's essay 'Science as a Vocation'. An understanding of the personal dimensions of trust and authority in science suggests practical limits to the position of Giddens on the disembedding of social relations and on the scepticism and reflexivity of modernity. PMID:11321228

  14. Michael Servetus (1511-1553) and the discovery of pulmonary circulation.

    PubMed

    Stefanadis, Christodoulos; Karamanou, Marianna; Androutsos, George

    2009-01-01

    Michael Servetus was the first doctor ever to challenge and scientifically argue against the theories of Galen, which predominated for 14 centuries in medical schools worldwide. Even though he was relatively correct in scientific terms, Servetus was punished because of his boldness in challenging Galen's theories and was condemned to death by the Holy Inquisition. Yet, by publicly challenging Galen's and Hippocrates' predominant and unquestionable lessons on medicine for the first time, Servetus opened the door for other doctors to challenge and correct those theories and subsequently to bring about a new view of human anatomy and physiology. This article underlines the contribution of Servetus to the description of the pulmonary circulation. PMID:19774731

  15. Dextran-based hydrogel formed by thiol-Michael addition reaction for 3D cell encapsulation.

    PubMed

    Liu, Zhen Qi; Wei, Zhao; Zhu, Xv Long; Huang, Guo You; Xu, Feng; Yang, Jian Hai; Osada, Yoshihito; Zrínyi, Miklós; Li, Jian Hui; Chen, Yong Mei

    2015-04-01

    Cell encapsulation in three-dimensional (3D) hydrogels can mimic native cell microenvironment and plays a major role in cell-based transplantation therapies. In this contribution, a novel in situ-forming hydrogel, Dex-l-DTT hydrogel ("l" means "linked-by"), by cross-linking glycidyl methacrylate derivatized dextran (Dex-GMA) and dithiothreitol (DTT) under physiological conditions, has been developed using thiol-Michael addition reaction. The mechanical properties, gelation process and degree of swelling of the hydrogel can be easily adjusted by changing the pH of phosphate buffer saline. The 3D cell encapsulation ability is demonstrated by encapsulating rat bone marrow mesenchymal stem cells (BMSCs) and NIH/3T3 fibroblasts into the in situ-forming hydrogel with maintained high viability. The BMSCs also maintain their differentiation potential after encapsulation. These results demonstrate that the Dex-l-DTT hydrogel holds great potential for biomedical field. PMID:25744162

  16. Organocatalytic and enantioselective Michael reaction between α-nitroesters and nitroalkenes. Syn/anti-selectivity control using catalysts with the same absolute backbone chirality.

    PubMed

    Martínez, Jose I; Uria, Uxue; Muñiz, Maria; Reyes, Efraím; Carrillo, Luisa; Vicario, Jose L

    2015-01-01

    The asymmetric and catalytic Michael reaction between α-nitroesters and nitroalkenes has been studied in the presence of two bifunctional catalysts both containing the same absolute chirality at the carbon backbone. The reaction performed in similar conditions allows us to control the syn or anti selectivity of the Michael adduct obtaining good yields and high enantiocontrol in all cases. PMID:26734103

  17. Organocatalytic and enantioselective Michael reaction between α-nitroesters and nitroalkenes. Syn/anti-selectivity control using catalysts with the same absolute backbone chirality

    PubMed Central

    Martínez, Jose I; Uria, Uxue; Muñiz, Maria; Reyes, Efraím

    2015-01-01

    Summary The asymmetric and catalytic Michael reaction between α-nitroesters and nitroalkenes has been studied in the presence of two bifunctional catalysts both containing the same absolute chirality at the carbon backbone. The reaction performed in similar conditions allows us to control the syn or anti selectivity of the Michael adduct obtaining good yields and high enantiocontrol in all cases. PMID:26734103

  18. Concise Enantioselective Synthesis of Oxygenated Steroids via Sequential Copper(II)-Catalyzed Michael Addition/Intramolecular Aldol Cyclization Reactions

    PubMed Central

    Cichowicz, Nathan R.; Kaplan, Will; Khomutnyk, Yaroslav; Bhattarai, Bijay; Sun, Zhankui; Nagorny, Pavel

    2015-01-01

    A new scalable enantioselective approach to functionalized oxygenated steroids is described. This strategy is based on chiral bis(oxazoline) copper(II) complex-catalyzed enantioselective and diastereoselective Michael reactions of cyclic ketoesters and enones to install vicinal quaternary and tertiary stereocenters. In addition, the utility of copper(II) salts as highly active catalysts for the Michael reactions of traditionally unreactive ββ′-enones and substituted ββ′-ketoesters that results in unprecedented Michael adducts containing vicinal all-carbon quaternary centers is also demonstrated. The Michael adducts subsequently undergo base-promoted diastereoselective aldol cascade reactions resulting in the natural or unnatural steroid skeletons. The experimental and computational studies suggest that the torsional strain effects arising from the presence of the Δ5-unsaturation are key controling elements for the formation of the natural cardenolide scaffold. The described method enables expedient generation of polycyclic molecules including modified steroidal scaffolds as well as challenging-to-synthesize Hajos-Parrish and Wieland-Miescher ketones. PMID:26491886

  19. What I Think I May Have Learned--Reflections on 50 Years of Teaching: An Interview with Michael Wertheimer

    ERIC Educational Resources Information Center

    Michael, Kurt D.

    2006-01-01

    Kurt Michael is an associate professor in the Department of Psychology at Appalachian State University (ASU) where he teaches history and systems of psychology, abnormal psychology, child psychopathology, and interventions for children and adolescents. He received his BA (cum laude) from the University of Colorado at Boulder and his MS and PhD in…

  20. Unexpected Michael Additions on the Way to 2.3,8.9-Dibenzanthanthrenes with Interesting Structural Properties.

    PubMed

    Reus, Christian; Lechner, Marc P; Schulze, Matthias; Lungerich, Dominik; Diner, Colin; Gruber, Marco; Stryker, Jeffrey M; Hampel, Frank; Jux, Norbert; Tykwinski, Rik R

    2016-06-27

    The synthesis and properties of a new polycyclic aromatic hydrocarbon containing eight annulated rings and based on the anthanthrene core is described. An unexpected, nucleophile-dependent Michael addition to a dibenzanthanthrene-1,7-dione is found, giving a product with three triisopropylsilylacetylene units and a remarkable solid-state structure (as determined by X-ray crystallography). PMID:27140668

  1. Michael Novak's "Business as a Calling" as a Vehicle for Addressing Ethical and Policy Concerns in a Business Law Course

    ERIC Educational Resources Information Center

    Murphy, Tonia Hap

    2008-01-01

    This article describes the author's experience of incorporating Michael Novak's "Business as a Calling: Work and the Examined Life" into a Business Law course. The author views it as a positive addition to the course, one that may be of interest to her colleagues at other institutions. Accordingly, after an overview of Novak's analysis in…

  2. 78 FR 2391 - CAlifornians for Renewable Energy, Inc., Michael E. Boyd, Robert M. Sarvey v. Pacific Gas and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-11

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission CAlifornians for Renewable Energy, Inc., Michael E. Boyd, Robert M. Sarvey v... and Procedure of the Federal Energy Regulatory Commission (FERC); CAlifornians for Renewable...

  3. A Symposium on the Relevance of Michael Polanyi's Insights to a Reformulated Understanding of Science, Technology, and Society

    ERIC Educational Resources Information Center

    Mead, Walter B.

    2011-01-01

    This is intended as an introductory statement to the explorations undertaken in the essays that follow. The authors of these essays attempt to introduce the reader to some of the insights of Michael Polanyi and their implications for the reader who wishes to come to a greater understanding of modern technological society, which--for better or…

  4. Asymmetric Synthesis of CF3- and Indole-Containing Thiochromanes via a Squaramide-Catalyzed Michael-Aldol Reaction.

    PubMed

    Zhu, Yuanyuan; Dong, Zhenghao; Cheng, Xin; Zhong, Xiaoling; Liu, Xiaolin; Lin, Li; Shen, Zhiqiang; Yang, Peiju; Li, Yuan; Wang, Hailin; Yan, Wenjin; Wang, Kairong; Wang, Rui

    2016-08-01

    A Michael-aldol reaction of 2-mercaptobenzaldehyde with β-indole-β-CF3 enones catalyzed by a squaramide has been realized. The method affords a series of 2-CF3-2-indole-substituted thiochromanes featuring a CF3-containing quaternary stereocenter in excellent yields, diastereoselectivities, and enantioselectivities. PMID:27390924

  5. Domino alkylation/oxa-Michael of 1,3-cyclohexanediones: steering the C/O-chemoselectivity to reach tetrahydrobenzofuranones.

    PubMed

    Devi, Rema B; Henrot, Matthias; De Paolis, Michaël; Maddaluno, Jacques

    2011-10-01

    An unprecedented domino synthesis of tetrahydrobenzofuran-4-ones is described implicating chemoselective alkylation of various 1,3-cyclohexanediones with bromocrotonate or crotonitrile followed by oxa-Michael cyclization. Further transformations of this core to reach molecular diversity are also presented. PMID:21826296

  6. A Philosophy of Jewish Education in Question Marks: A Possible Reading of Michael Rosenak's Last Speech

    ERIC Educational Resources Information Center

    Rosenak, Avinoam

    2014-01-01

    Writing this article presents me with an opportunity to look closely at the last speech that my father and mentor, Professor Michael (Mike) Rosenak z"l gave before his passing in 2013. I will write about this speech from a perspective that is based on my intimate familiarity with the questions that concerned him throughout his life. I will…

  7. Enantioselective Construction of Spirocyclic Oxindole Derivatives with Multiple Stereocenters via an Organocatalytic Michael/Aldol/Hemiacetalization Cascade Reaction.

    PubMed

    Zhu, Luyi; Chen, Qiliang; Shen, Dan; Zhang, Weihao; Shen, Cong; Zeng, Xiaofei; Zhong, Guofu

    2016-05-20

    An efficient organocatalytic Michael/aldol/hemiacetalization cascade reaction for construction of enantioenriched spirocyclic oxindoles fused with tetrahydropyrane has been developed. The desired highly functionalized 5',6'-dihydro-2'H,4'H-spiro[indoline-3,3'-pyran]-2-one derivatives containing multiple stereogenic centers were obtained in moderate to high chemical yields and with high stereoselectivities. PMID:27145022

  8. Effective Integration of Technology and Instruction. Q&A with Michael Jay. REL Mid-Atlantic Educator Effectiveness Webinar Series

    ERIC Educational Resources Information Center

    Regional Educational Laboratory Mid-Atlantic, 2015

    2015-01-01

    In this webinar, long-time educator and developer of education technology Michael Jay discussed the importance of using technology to support learning and gave examples of how teachers can integrate technology into their instruction based on the Common Core State Standards and the Next Generation Science Standards. The PowerPoint presentation and…

  9. Attending to hidden realities: contributions from the work of Michael Polanyi to supervision in pastoral care and counseling.

    PubMed

    Rodgerson, Thomas E

    2008-01-01

    In this article, the author suggests that concepts from the work of Michael Polanyi--such as the tacit dimension, subsidiary awareness, and commitment to a yet unrevealed, hidden reality--provide a theoretical basis for understanding the unique formation involved in pastoral care and counseling supervision. PMID:18947101

  10. Sight, Sound, and Knowledge: Michael Polanyi's Epistemology as an Attempt to Redress the Sensory Imbalance in Modern Western Thought

    ERIC Educational Resources Information Center

    Jardine, Murray

    2011-01-01

    The author argues that Michael Polanyi's philosophy of science can be understood as an (unconscious) attempt to recapture elements of experience largely forgotten or repressed in modernity. Specifically, the author argues that Polanyi's epistemology appears to draw on elements of oral-aural experience that have been relatively ignored by the…

  11. "Stand Therefore!" -Bishop Michael Bolton Furse, the Diocese of St. Albans, and the Church Schools Controversy, 1919-1939.

    ERIC Educational Resources Information Center

    Parker, David

    1999-01-01

    Analyzes the educational problems and opportunities facing Hertfordshire (England) and the Anglican Diocese of St. Albans. Argues that the anxieties and aspirations of parishes and dioceses within the Church of England influenced the pace and nature of educational developments. Considers the involvement of Bishop Michael Bolton Furse. (CMK)

  12. On further generalization of the rigidity theorem for spacetimes with a stationary event horizon or a compact Cauchy horizon

    NASA Astrophysics Data System (ADS)

    Rácz, István

    2000-01-01

    A rigidity theorem that applies to smooth electrovacuum spacetimes which represent either (A) an asymptotically flat stationary black hole or (B) a cosmological spacetime with a compact Cauchy horizon ruled by closed null geodesics was given in a recent paper by Friedrich et al (1999 Commun. Math. Phys. 204 691-707). Here we enlarge the framework of the corresponding investigations by allowing the presence of other types of matter fields. In the first part the matter fields are involved merely implicitly via the assumption that the dominant energy condition is satisfied. In the second part Einstein-Klein-Gordon (EKG), Einstein-[non-Abelian]-Higgs (E[nA]H), Einstein-[Maxwell]-Yang-Mills-dilaton (E[M]YMd) and Einstein-Yang-Mills-Higgs (EYMH) systems are studied. The black hole event horizon or, respectively, the compact Cauchy horizon of the considered spacetimes is assumed to be a smooth non-degenerate null hypersurface. It is proved that there exists a Killing vector field in a one-sided neighbourhood of the horizon in EKG, E[nA]H, E[M]YMd and EYMH spacetimes. This Killing vector field is normal to the horizon, moreover, the associated matter fields are also shown to be invariant with respect to it. The presented results provide generalizations of the rigidity theorems of Hawking (for case A) and of Moncrief and Isenberg (for case B) and, in turn, they strengthen the validity of both the black hole rigidity scenario and the strong cosmic censor conjecture of classical general relativity.

  13. Antarctic Genomics

    PubMed Central

    Clarke, Andrew; Cockell, Charles S.; Convey, Peter; Detrich III, H. William; Fraser, Keiron P. P.; Johnston, Ian A.; Methe, Barbara A.; Murray, Alison E.; Peck, Lloyd S.; Römisch, Karin; Rogers, Alex D.

    2004-01-01

    With the development of genomic science and its battery of technologies, polar biology stands on the threshold of a revolution, one that will enable the investigation of important questions of unprecedented scope and with extraordinary depth and precision. The exotic organisms of polar ecosystems are ideal candidates for genomic analysis. Through such analyses, it will be possible to learn not only the novel features that enable polar organisms to survive, and indeed thrive, in their extreme environments, but also fundamental biological principles that are common to most, if not all, organisms. This article aims to review recent developments in Antarctic genomics and to demonstrate the global context of such studies. PMID:18629155

  14. 78 FR 33431 - Deepwater Horizon Oil Spill; Notice of Intent To Prepare a Programmatic Environmental Impact...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-04

    ... Deepwater Horizon Oil Spill; Notice of Intent To Prepare a Programmatic Environmental Impact Statement for a... state natural resource trustees for the Deepwater Horizon oil spill (Trustees) intend to prepare a PEIS... discharges from the rig and from the wellhead on the seabed. The Deepwater Horizon oil spill is the...

  15. 33 CFR 147.T08-849 - DEEPWATER HORIZON Mobile Offshore Drilling Unit Safety Zone.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false DEEPWATER HORIZON Mobile Offshore... DEEPWATER HORIZON Mobile Offshore Drilling Unit Safety Zone. (a) Location. All areas within 500 meters (1640... area surrounds the DEEPWATER HORIZON, a Mobile Offshore Drilling Unit (MODU), that sank in...

  16. 78 FR 8184 - DEEPWATER HORIZON Oil Spill; Final Phase II Early Restoration Plan and Environmental Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-05

    ... DEEPWATER HORIZON Oil Spill; Final Phase II Early Restoration Plan and Environmental Review AGENCY: Interior... Addressing Injuries Resulting from the DEEPWATER HORIZON Oil Spill (Framework Agreement), notice is hereby... services injured or lost as a result of the DEEPWATER HORIZON oil spill, which occurred on or about...

  17. 77 FR 23741 - DEEPWATER HORIZON Oil Spill; Final Phase I Early Restoration Plan and Environmental Assessment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-20

    ... Fish and Wildlife Service DEEPWATER HORIZON Oil Spill; Final Phase I Early Restoration Plan and... DEEPWATER HORIZON Oil Spill (Framework Agreement), notice is hereby given that ] the Federal and State... the DEEPWATER HORIZON oil spill, which occurred on or about April 20, 2010, in the Gulf of Mexico....

  18. 50 CFR 622.14 - Area closures related to the Deepwater Horizon oil spill.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Horizon oil spill. 622.14 Section 622.14 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT... spill. (a) Caribbean EEZ area closure related to Deepwater Horizon oil spill. Effective May 11, 2010... Web site: http://sero.nmfs.noaa.gov/deepwater_horizon_oil_spill.htm. (b) Gulf EEZ area closure...

  19. 76 FR 78016 - Deepwater Horizon Oil Spill; Draft Phase I Early Restoration Plan and Environmental Assessment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-15

    ....S. Fish and Wildlife Service, Interior Deepwater Horizon Oil Spill; Draft Phase I Early Restoration... from the Deepwater Horizon Oil Spill, the Federal and State natural resource trustee agencies (Trustees... resources and services injured or lost as a result of the Deepwater Horizon oil spill, which occurred on...

  20. 78 FR 26319 - Deepwater Horizon Oil Spill; Proposal of Future Early Restoration Projects and Environmental Reviews

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-06

    ... National Oceanic and Atmospheric Administration Deepwater Horizon Oil Spill; Proposal of Future Early... Horizon oil spill (Trustees) intend to propose the additional early restoration projects described below... services, and human use services injured or lost as a result of the Deepwater Horizon oil spill...

  1. Aluminum solubility control in different horizons of a podzol

    SciTech Connect

    Zysset, M.; Blaser, P.; Luster, J.; Gehring, A.U.

    1999-10-01

    In the last two decades, the anthropogenically induced acceleration of forest soil acidification has been a topic of environmental concern. Aluminum extractability and solubility were investigated in detail in six horizons of a Typic Haplohumod (FAO:Haplic Podzol) from southern Switzerland. Pyrophosphate and oxalate extractions as well as successive acid leaching indicated that in the Ah, (AE), and Bh horizons reactive Al is mainly bound to soil organic matter, whereas in the Bs, BC1, and BC2 horizons it is of inorganic nature. In the latter three horizons, infrared (IR) spectroscopy and transmission electron microscopy (TEM) revealed the presence of imogolite. Batch equilibrium experiments at 20 C in the pH range of approximately 3.5 to 5.5 showed that the podzol profile can be divided into two parts of different Al solubility control. In the Ah and (AE) horizons, Al solubility was found to be controlled by complexation reactions to soil organic matter. Kinetic studies with samples of the Bh, Bs, BC1, and BC2 horizons showed that ion activity products with respect to both Al(OH){sub 3} and imogolite, (HO){sub 3}Al{sub 2}O{sub 3}SiOH, reached a constant value after reaction times of 16 d. For pH {gt}4.1, the compilation of all data revealed pAl + 0.5 pSi = 3.05 pH {minus} 7.04 (r{sup 2} = 0.99) and pAl = 2.87 pH {minus} 8.07 (r{sup 2} = 0.99). These data could be shown to be consistent with either Al solubility control by imogolite-type material (ITM) with a log *K{sub s}{sup 0} = 6.53 {+-} 0.09, which dissolves incongruently, or a simultaneous equilibrium with ITM and hydroxy-Al interlayers of clay minerals. For pH {lt} 4.1, data indicated solubility control by a 1:1 aluminosilicate, e.g., poorly crystalline kaolinite.

  2. Genomic Testing

    MedlinePlus

    ... Working Group Independent Web site Informing the effective integration of genomics into health practice—Lynch syndrome ACCE Model for Evaluating Genetic Tests Recommendations by the EGAPP Working Group Top of ... ...

  3. The Exploration of the Pluto System by New Horizons

    NASA Astrophysics Data System (ADS)

    Stern, S. Alan; NASA New Horizons Team

    2016-01-01

    The Pluto system was recently explored by NASA's New Horizons spacecraft, making closest approach on 14 July 2015. Pluto's surface displays diverse landforms, terrain ages, albedos, colors, and composition gradients. Evidence is found for a water-ice crust, geologically young surface units, surface ice convection, wind streaks, volatile transport, and glacial flow. Pluto's atmosphere is highly extended, with trace hydrocarbons, a global haze layer, and a surface pressure near 10 microbars. Pluto's diverse surface geology and long term activity raise fundamental questions about how small planets remain active many billions of years (Gyr) after formation. Pluto's large moon Charon displays tectonics and evidence for a heterogeneous crustal composition; its North Pole displays puzzling dark terrain. Small satellites Hydra and Nix have higher albedos than expected. In this talk I will summarize the objectives of the New Horizons mission, its scientific payload, and survey key results obtained to date about Pluto and its system of moons.

  4. A horizon scan of global conservation issues for 2012.

    PubMed

    Sutherland, William J; Aveling, Ros; Bennun, Leon; Chapman, Eleanor; Clout, Mick; Côté, Isabelle M; Depledge, Michael H; Dicks, Lynn V; Dobson, Andrew P; Fellman, Liz; Fleishman, Erica; Gibbons, David W; Keim, Brandon; Lickorish, Fiona; Lindenmayer, David B; Monk, Kathryn A; Norris, Kenneth; Peck, Lloyd S; Prior, Stephanie V; Scharlemann, Jörn P W; Spalding, Mark; Watkinson, Andrew R

    2012-01-01

    Our aim in conducting annual horizon scans is to identify issues that, although currently receiving little attention, may be of increasing importance to the conservation of biological diversity in the future. The 15 issues presented here were identified by a diverse team of 22 experts in horizon scanning, and conservation science and its application. Methods for identifying and refining issues were the same as in two previous annual scans and are widely transferable to other disciplines. The issues highlight potential changes in climate, technology and human behaviour. Examples include warming of the deep sea, increased cultivation of perennial grains, burning of Arctic tundra, and the development of nuclear batteries and hydrokinetic in-stream turbines. PMID:22133790

  5. Deepwater Horizon oil spill impacts on Alabama beaches

    NASA Astrophysics Data System (ADS)

    Hayworth, J. S.; Clement, T. P.; Valentine, J. F.

    2011-12-01

    From mid June 2010 to early August 2010, the white sandy beaches along Alabama's Gulf coast were inundated with crude oil discharged from the Deepwater Horizon well. The long-term consequences of this environmental catastrophe are still unfolding. Although BP has attempted to clean up some of these beaches, there still exist many unanswered questions regarding the physical, chemical, and ecological state of the oil contaminated beach system. In this paper, we present our understanding of what is known and known to be unknown with regard to the current state of Alabama's beaches in the aftermath of the Deepwater Horizon disaster. Motivated by our observations of the evolving distribution of oil in Alabama's beaches and BP's clean-up activities, we offer our thoughts on the lessons learned from this oil spill disaster.

  6. Deepwater Horizon oil spill impacts on Alabama beaches

    NASA Astrophysics Data System (ADS)

    Hayworth, J. S.; Clement, T. P.; Valentine, J. F.

    2011-07-01

    From mid June 2010 to early August 2010, the white sandy beaches along Alabama's Gulf coast were inundated with crude oil discharged from the Deepwater Horizon well. The long-term consequences of this environmental catastrophe are still unfolding. Although BP has attempted to clean up some of these beaches, there still exist many unanswered questions regarding the physical, chemical, and ecological state of the oil contaminated beach system. In this paper, we present our understanding of what is known and known to be unknown with regard to the current state of Alabama's beaches in the aftermath of the Deepwater Horizon disaster. Motivated by our observations of the evolving distribution of oil in Alabama's beaches and BP's clean-up activities, we offer our thoughts on the lessons learned from this oil spill disaster.

  7. A horizon scan for species conservation by zoos and aquariums.

    PubMed

    Gusset, Markus; Fa, John E; Sutherland, William J

    2014-01-01

    We conducted the first horizon scan for zoos and aquariums to identify the 10 most important emerging issues for species conservation. This involved input from more than 100 experts from both the wider conservation community and the world zoo and aquarium community. Some of the issues are globally important: diseases, zoonoses, and biosecurity issues; new (communication) technologies; global water shortage and food insecurity; developing economies and markets for wildlife consumption; changes in wildlife population dynamics; and political instability and conflicts. Other issues are more specific to zoos and aquariums: need for extractive reserves; space shortage in zoos and aquariums; need for metapopulation management; and demand for caring of more species in zoos and aquariums. We also identified some broad approaches to these issues. Addressing the emerging issues identified in our horizon scan will further increase the contribution of the world zoo and aquarium community to global biodiversity conservation. PMID:25065560

  8. New perspectives for European climate services: HORIZON2020

    NASA Astrophysics Data System (ADS)

    Bruning, Claus; Tilche, Andrea

    2014-05-01

    The developing of new end-to-end climate services was one of the core priorities of 7th Framework for Research and Technological Development of the European Commission and will become one of the key strategic priorities of Societal Challenge 5 of HORIZON2020 (the new EU Framework Programme for Research and Innovation 2014-2020). Results should increase the competitiveness of European businesses, and the ability of regional and national authorities to make effective decisions in climate-sensitive sectors. In parallel, the production of new tailored climate information should strengthen the resilience of the European society to climate change. In this perspective the strategy to support and foster the underpinning science for climate services in HORIZON2020 will be presented.

  9. Large superconformal near-horizons from M-theory

    NASA Astrophysics Data System (ADS)

    Kelekci, Ö.; Lozano, Y.; Montero, J.; O'Colgáin, E.; Park, M.

    2016-04-01

    We report on a classification of supersymmetric solutions to 11D supergravity with S O (2 ,2 )×S O (3 ) isometry, which are AdS /CFT dual to 2D CFTs with N =(0 ,4 ) supersymmetry. We recover the Maldacena, Strominger, Witten near-horizon with small superconformal symmetry and identify a class of AdS3×S2×S2×C Y2 geometries with emergent large superconformal symmetry. This exhausts known compact geometries. Compactification of M-theory on C Y2 results in a vacuum of 7D supergravity with large superconformal symmetry, providing a candidate near-horizon for an extremal black hole and a potential new setting to address microstates.

  10. Failing a student nurse: a new horizon of moral courage.

    PubMed

    Black, Sharon; Curzio, Joan; Terry, Louise

    2014-03-01

    The factors preventing registered nurses from failing students in practice are multifaceted and have attracted much debate over recent years. However, writers rarely focus on what is needed to fail an incompetent pre-registration nursing student in their final placement. This hermeneutic study explored the mentor experience of failing a pre-registration nursing student in their final placement. A total of 19 mentors were recruited from 7 different healthcare organisations in both inner city and rural locations in the southeast of England. Participants took part in individual reflective interviews about their experience of failing a pre-registration nursing student in their final placement. These experiences were interpreted through a hermeneutic discovery of meaning. The new horizon of understanding which developed as a result of this research is framed within the context of moral stress, moral integrity and moral residue with the overall synthesis being that these mentors' stories presented a new horizon of moral courage. PMID:23989859

  11. Atmospheric Results from the MGS Horizon Science Experiment

    NASA Technical Reports Server (NTRS)

    Martin, T. Z.; Murphy, J. R.; Hollingsworth, J. L.

    1999-01-01

    The Horizon Science Experiment (HORSE) utilizes the Mars Horizon Sensor Assembly (MHSA) on the Mars Global Surveyor (MGS) orbiter to measure 15-micron band thermal emission from the Martian atmosphere. During the first two phases of aerobraking, from September 1997 to May 1998, and from September 1998 to March 1999, one of the four MGS quadrants was pointed well onto the planet consistently during the near-periapsis aerobraking passes, allowing the device to obtain data on the latitudinal variation of middle atmospheric temperature (0.2 - 2.0 mbar). Of particular interest during the first phase (L(sub s) = 182 - 300 deg) were the effects of a prominent dust storm at L(sub s) =224 deg, and wavelike behavior in the strong temperature gradient near the north polar cap. Additional information is contained in the original extended abstract.

  12. Hawking radiation and near horizon universality of chiral Virasoro algebra

    NASA Astrophysics Data System (ADS)

    Banerjee, Rabin; Gangopadhyay, Sunandan; Kulkarni, Shailesh

    2010-12-01

    We show that the diffeomorphism anomaly together with the trace anomaly reveal a chiral Virasoro algebra near the event horizon of a black hole. This algebra is the same irrespective of whether the anomaly is covariant or consistent, thereby manifesting its universal character and the fact that only the outgoing modes are relevant near the horizon. Our analysis therefore clarifies the role of the trace anomaly in the diffeomorphism anomaly approach [Robinson and Wilczek in Phys. Rev. Lett. 95:011303, 2005; Iso et al. in Phys. Rev. Lett. 96:151302, 2006; Banerjee and Kulkarni in Phys. Rev. D 77:024018, 2008; Gangopadhyay and Kulkarni in Phys. Rev. D 77:024038, 2008] to the Hawking radiation.

  13. Digital Signal Processing for the Event Horizon Telescope

    NASA Astrophysics Data System (ADS)

    Weintroub, Jonathan

    2015-08-01

    A broad international collaboration is building the Event Horizon Telescope (EHT). The aim is to test Einstein’s theory of General Relativity in one of the very few places it could break down: the strong gravity regime right at the edge of a black hole. The EHT is an earth-size VLBI array operating at the shortest radio wavelengths, that has achieved unprecedented angular resolution of a few tens of μarcseconds. For nearby super massive black holes (SMBH) this size scale is comparable to the Schwarzschild Radius, and emission in the immediate neighborhood of the event horizon can be directly observed. We give an introduction to the science behind the CASPER-enabled EHT, and outline technical developments, with emphasis on the secret sauce of high speed signal processing.

  14. Skyrme black holes in the isolated horizons formalism

    SciTech Connect

    Nielsen, Alex B.

    2006-08-15

    We study static, spherically symmetric, Skyrme black holes in the context of the assumption that they can be viewed as bound states between ordinary bare black holes and solitons. This assumption and results stemming from the isolated horizons formalism lead to several conjectures about the static black hole solutions. These conjectures are tested against the Skyrme black hole solutions. It is shown that, while there is in general good agreement with the conjectures, a crucial aspect seems to violate one of the conjectures.

  15. New Horizons Regional Education Center 1999 FIRST Robotics Competition

    NASA Technical Reports Server (NTRS)

    Purman, Richard I.

    1999-01-01

    The New Horizons Regional Education Center (NHREC) in Hampton, VA sought and received NASA funding to support its participation in the 1999 FIRST Robotics competition. FIRST, Inc. (For Inspiration and Recognition of Science and Technology) is an organization which encourages the application of creative science, math, and computer science principles to solve real-world engineering problems. The FIRST competition is an international engineering contest featuring high school, government, and business partnerships.

  16. New Horizons Regional Education Center 2001 FIRST Robotics Competition

    NASA Technical Reports Server (NTRS)

    2001-01-01

    The New Horizons Regional Education Center (NHREC) in Hampton, VA sought and received NASA funding to support its participation in the 2001 FIRST Robotics competition. FIRST, Inc. (For Inspiration and Recognition of Science and Technology) is an organization which encourages the application of creative science, math, and computer science principles to solve real-world engineering problems. The FIRST competition is an international engineering contest featuring high school, government, and business partnerships.

  17. The New Horizons Mission to Pluto and the Kuiper Belt

    NASA Astrophysics Data System (ADS)

    Weaver, H. A.; Stern, S. A.; New Horizons Science; Engineering Team

    New Horizons, which initiates the NASA New Frontiers program of mid-sized missions, will provide the first scientific reconnaissance of the Pluto-Charon system and is scheduled for launch in January 2006. An encounter with Jupiter at a flyby distance of ˜32-45 RJ about 13 months after launch provides a gravity boost for the spacecraft's journey to Pluto and practice for the Pluto encounter, in addition to providing an opportunity to perform a valuable set of scientific measurements within the jovian system. New Horizons carries a sophisticated suite of instruments to perform ultraviolet and infrared spectroscopy, panchromatic and color optical imaging, and charged particle and dust measurements, all within a spacecraft having a total mass of ˜465 kg and total power output of ˜210 W at the time of Pluto encounter in July 2015. The primary scientific objectives of the New Horizons are to characterize the global geology and morphology of Pluto and Charon, map the surface composition of Pluto and Charon, and characterize the neutral atmosphere and its escape rate, but many other important scientific objectives will be addressed as well. New Horizons has the capability to image Pluto with a resolution exceeding that provided by the Hubble Space Telescope for at least 90 days prior to closest approach at a distance of ˜10,000 km from the surface, at which time a resolution of ˜100 m will be achieved for selected regions near the terminator. After encounter, the spacecraft will pass through the shadows of both Pluto and Charon, which enables radio and ultraviolet occultation measurements of their atmospheres. If an extended mission phase is approved, the spacecraft will be re-targeted to encounter one or more Kuiper belt objects (KBOs), roughly 3 years after the Pluto encounter at a heliocentric distance of ˜42 AU. The scientific objectives for the KBO encounters are similar to those for the Pluto encounter.

  18. Typical event horizons in AdS/CFT

    NASA Astrophysics Data System (ADS)

    Avery, Steven G.; Lowe, David A.

    2016-01-01

    We consider the construction of local bulk operators in a black hole background dual to a pure state in conformal field theory. The properties of these operators in a microcanonical ensemble are studied. It has been argued in the literature that typical states in such an ensemble contain firewalls, or otherwise singular horizons. We argue this conclusion can be avoided with a proper definition of the interior operators.

  19. Summary and status of the Horizons ephemeris system

    NASA Astrophysics Data System (ADS)

    Giorgini, J.

    2011-10-01

    Since 1996, the Horizons system has provided searchable access to JPL ephemerides for all known solar system bodies, several dozen spacecraft, planetary system barycenters, and some libration points. Responding to 18 400 000 requests from 300 000 unique addresses, the system has recently averaged 420 000 ephemeris requests per month. Horizons is accessed and automated using three interfaces: interactive telnet, web-browser form, and e-mail command-file. Asteroid and comet ephemerides are numerically integrated from JPL's database of initial conditions. This small-body database is updated hourly by a separate process as new measurements and discoveries are reported by the Minor Planet Center and automatically incorporated into new JPL orbit solutions. Ephemerides for other objects are derived by interpolating previously developed solutions whose trajectories have been represented in a file. For asteroids and comets, such files may be dynamically created and transferred to users, effectively recording integrator output. These small-body SPK files may then be interpolated by user software to reproduce the trajectory without duplicating the numerically integrated n-body dynamical model or PPN equations of motion. Other Horizons output is numerical and in the form of plain-text observer, vector, osculating element, or close-approach tables, typically expected be read by other software as input. About one hundred quantities can be requested in various time-scales and coordinate systems. For JPL small-body solutions, this includes statistical uncertainties derived from measurement covariance and state transition matrices. With the exception of some natural satellites, Horizons is consistent with DE405/DE406, the IAU 1976 constants, ITRF93, and IAU2009 rotational models.

  20. Hawking spectrum for a fiber-optical analog of the event horizon

    NASA Astrophysics Data System (ADS)

    Bermudez, David; Leonhardt, Ulf

    2016-05-01

    Hawking radiation has been regarded as a more general phenomenon than in gravitational physics, in particular in laboratory analogs of the event horizon. Here we consider the fiber-optical analog of the event horizon, where intense light pulses in fibers establish horizons for probe light. Then, we calculate the Hawking spectrum in an experimentally realizable system. We found that the Hawking radiation is peaked around group-velocity horizons in which the speed of the pulse matches the group velocity of the probe light. The radiation nearly vanishes at the phase horizon where the speed of the pulse matches the phase velocity of light.