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1

The Global Forest Resource Assessment FRA2010 and  

E-print Network

intensity: about 1 % ( 1.2 % of land surface) Remote sensing sampling framework #12;Social networks ­ usingThe Global Forest Resource Assessment FRA2010 and Remote Sensing Survey work by FAO and partners Assessment (FRA) process and 2005 results The new FRA Remote Sensing Survey (RSS) Potential opportunities

2

76 FR 41859 - Waiver Petition Docket Numbers FRA-2011-0002, CSX Transportation Railroad, and FRA-2004-17565...  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF TRANSPORTATION Federal Railroad Administration Waiver Petition Docket Numbers FRA-2011-0002, CSX Transportation Railroad, and FRA-2004-17565, Union Pacific Railroad; Public Hearing On February 23,...

2011-07-15

3

75 FR 27112 - Solicitation of Applications and Notice of Funding Availability for the FRA Railroad System...  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF TRANSPORTATION Federal Railroad Administration Solicitation of Applications...of Funding Availability for the FRA Railroad System Issues Research and Development Program AGENCY: Federal Railroad Administration (FRA),...

2010-05-13

4

75 FR 34213 - Solicitation of Applications and Notice of Funding Availability for the FRA Railroad System...  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF TRANSPORTATION Federal Railroad Administration Solicitation of Applications...of Funding Availability for the FRA Railroad System Issues Research and Development Program AGENCY: Federal Railroad Administration (FRA),...

2010-06-16

5

Tissue-specific transgenic knockdown of Fos-related antigen 2 (Fra-2) expression mediated by dominant negative Fra-2.  

PubMed

Fos-related antigen 2 (Fra-2) is a member of the Fos family of immediate-early genes, most of which are rapidly induced by second messengers. All members of this family act by binding to AP-1 sites as heterodimeric complexes with other proteins. However, each appears to have a distinct role. The role and biology of Fra-2 are less well understood than those of its relatives c-Fos, Fra-1, and FosB; moreover, Fra-2 target genes remain largely unknown, as does the basis of its selective effects on transcriptional activity. To pursue these issues, we created a transgenic rat line (NATDNF2) in which a dominant negative fra-2 (DNF2) gene is strongly expressed in the pineal gland; tissue selectivity was achieved by putting the DNF2 gene under the control of the rat arylalkylamine N-acetyltransferase (AANAT) regulatory region, which targets gene expression to a very restricted set of tissues (pineal gland > retina). Expression of AANAT is normally turned on after the onset of darkness in the rat; as a result, pineal DNF2 expression occurs only at night. This was associated with marked suppression of the nocturnal increase in fra-2 mRNA and protein levels, indicating that DNF2 expression inhibits downstream effects of Fra-2, including the maintenance of high levels of fra-2 gene expression. Analysis of 1,190 genes in the NATDNF2 pineal gland, including the AANAT gene, identified two whose expression is strongly linked to fra-2 expression: the genes encoding type II iodothyronine deiodinase and nectadrin (CD24). PMID:11340164

Smith, M; Burke, Z; Humphries, A; Wells, T; Klein, D; Carter, D; Baler, R

2001-06-01

6

49 CFR 240.103 - Approval of design of individual railroad programs by FRA.  

Code of Federal Regulations, 2011 CFR

...false Approval of design of individual railroad programs by FRA. 240.103 Section...Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION...103 Approval of design of individual railroad programs by FRA. (a)...

2011-10-01

7

49 CFR 242.103 - Approval of design of individual railroad programs by FRA.  

Code of Federal Regulations, 2013 CFR

...false Approval of design of individual railroad programs by FRA. 242.103 Section...Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION...103 Approval of design of individual railroad programs by FRA. (a) Each...

2013-10-01

8

49 CFR 240.103 - Approval of design of individual railroad programs by FRA.  

Code of Federal Regulations, 2012 CFR

...false Approval of design of individual railroad programs by FRA. 240.103 Section...Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION...103 Approval of design of individual railroad programs by FRA. (a)...

2012-10-01

9

49 CFR 240.103 - Approval of design of individual railroad programs by FRA.  

Code of Federal Regulations, 2013 CFR

...false Approval of design of individual railroad programs by FRA. 240.103 Section...Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION...103 Approval of design of individual railroad programs by FRA. (a)...

2013-10-01

10

49 CFR 242.103 - Approval of design of individual railroad programs by FRA.  

Code of Federal Regulations, 2012 CFR

...false Approval of design of individual railroad programs by FRA. 242.103 Section...Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION...103 Approval of design of individual railroad programs by FRA. (a) Each...

2012-10-01

11

49 CFR 240.103 - Approval of design of individual railroad programs by FRA.  

Code of Federal Regulations, 2010 CFR

...false Approval of design of individual railroad programs by FRA. 240.103 Section...Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION...103 Approval of design of individual railroad programs by FRA. (a)...

2010-10-01

12

TO: Persons Joining the Fermilab (FRA) Staff SUBJECT: Inventions and Employee Patent Agreement  

E-print Network

TO: Persons Joining the Fermilab (FRA) Staff SUBJECT: Inventions and Employee Patent Agreement in royalties received from patentable inventions to which FRA, LLC has taken title. As provided in FRA, LLC to sign a patent agreement. The attached form has been developed to comply with this requirement

Quigg, Chris

13

Samling af prsentationer fra workshop 7. juni 2007  

E-print Network

Samling af præsentationer fra workshop 7. juni 2007 Hotel Scandic Bygholm Park #12;Session 1B personalereduktioner har øget behovet for ekstern hjælp ·Outsourcing af ikke kerneprocesser ·Interessen for vertikale

14

Materialeforsker fra Ris tog springet og startede verdens frste virksom-  

E-print Network

friction stir welding - svejsning ved hjælp af omrørings-friktion - en ny teknolo- gi, som han tror så, ville det ikke have gjort den store forskel. Med friction stir welding er støj, røg og kraftigt lys fra flyalumini- um profiler. Med friction stir welding kan man dels slippe for nitter, dels for at bruge det

15

Fra-1/AP-1 Transcription Factor Negatively Regulates Pulmonary Fibrosis In Vivo  

PubMed Central

The Fra-1/AP-1 transcription factor plays a key role in tumor epithelial cell progression; however, its role in pathogenic lung fibrosis remains unclear. In the present study, using a genetic approach (Fra-1 deficient mice), we have demonstrated a novel regulatory (protective) role for Fra-1 in lung fibrosis. We found greater levels of progressive interstitial fibrosis, characterized by increased levels of inflammation, collagen accumulation, and profibrotic and fibrotic gene expression in the lungs of Fra-1?/? mice than in those of Fra-1+/+ mice following bleomycin treatment. Fra-1 knockdown in human lung epithelial cells caused the upregulation of mesenchymal marker N-cadherin, concomitant with a downregulation of the epithelial phenotype marker E-cadherin, under basal conditions and in response to bleomycin and TGF-?1. Furthermore, Fra-1 knockdown caused an enhanced expression of type 1 collagen and the downregulation of collagenase (MMP-1 and MMP-13) gene expression in human lung epithelial cells. Collectively, our findings demonstrate that Fra-1 mediates anti-fibrotic effects in the lung through the modulation of proinflammatory, profibrotic and fibrotic gene expression, and suggests that the Fra-1 transcription factor may be a potential target for pulmonary fibrosis, a progressive disorder with poor prognosis and treatment. PMID:22911824

Rajasekaran, Subbiah; Vaz, Michelle; Reddy, Sekhar P.

2012-01-01

16

Presence of hydroxyl in the Fra Mauro region  

NASA Astrophysics Data System (ADS)

Lunar pyroclastic deposits (LPDs) are known to consist of volcanic material (basalt and glass) ejected by eruptions [1]. In the southern part of the crater Fra Mauro, a localised LPD is associated with Rima Parry V [2]. In [3], a suppressed neutron flux is described for the Fra Mauro region based on measurements of the Lunar Exploration Neutron Detector (LEND) [4], interpreted as an indicator of hydroxyl (OH). In this study we compare these measurements with NIR hyperspectral data acquired by the Moon Mineralogy Mapper (M(3) ) [5] instrument. The suppression factor of the neutron flux is defined according to delta = (N_ref-N_ex)/N_ref [6,7] with N_ex as the average count rate of the omnidirectional sensor (SETN) [8] of LEND for the region under study (here: the Fra Mauro region) and N_ref as the average count rate for a reference area (here: immediately west of Fra Mauro). For Fra Mauro crater, a suppression factor of 2.4% with a standard error of 0.41% was found. The epithermal neutron flux can be assumed to be inversely proportional to the hydrogen content. Hence, the measured positive suppression factor indicates a positive anomaly of the hydrogen content at up to 1 m depth. Under the approximative assumption of a proportional relation between the suppression factor delta and the hydrogen content, the observation in [7] of a suppression factor of 18% in the crater Cabeus associated with a homogeneous hydrogen content of about 500 ppm implies an enrichment in hydrogen by about 70 ppm for the Fra Mauro region. However, these values do not specifically refer to the small Fra Mauro LPD but to a larger area of about 150 km diameter. To identify the LPD-specific suppression factor, it would be necessary to acquire collimated neutron flux measurements. We have complemented the LEND-based measurements by the analysis of spectral reflectance data acquired by the M(3) instrument. The presence of OH in the surface material leads to an absorption band beyond 2700 nm wavelength [9]. Based on the M(3) version V03 radiance data [10] and GLD100 topographic data [11], a topographically and photometrically corrected spectral reflectance data set normalised to 30() incidence angle, 0() emission angle and 30() phase angle [12] has been generated along with a refined DEM of high lateral resolution (cf. [13] for a detailed description of the applied processing steps). The depth of the OH absorption band is indicated by the reflectance ratio between the 2657 nm and 2817 nm bands (M(3) channels 77 and 81). In our map of the 2657/2817 reflectance ratio, the Fra Mauro LPD as well as a similar deposit in the northern part of the crater Bonpland stand out as positive anomalies exhibiting an increase of 2-2.5% with respect to the surrounding crater floor material. This observation indicates the presence of OH in the LPD surface material. Similar absorption depths can be observed for the inner walls and ejecta of a crater of 3 km diameter located north-northwest of the Fra Mauro LPD and of several craters with diameters less than 2 km in the northern floor of Bonpland. This behaviour may indicate the presence of OH also at larger depth below the surface. [1] Gaddis et al. (2003) Icarus 161(2), 262-280 [2] Head, J. W., Wilson, L. (1993) PSS 41(10), 719-727 [3] Sinitsyn et al. (2013) 4th Moscow Solar System Symp., 4MS3-PS14 [4] Mitrofanov et al. (2010a) Space Sci. Rev. 150(1-4), 183-207 [5] Pieters et al. (2009) Current Science 96(4), 500-505 [6] Boynton et al. (2012) JGR 117, E00H33 [7] Mitrofanov et al. (2010b) Science 330, 483-485 [8] Litvak et al. (2012) JGR 117, E00H22 [9] Clark et al. (2010) LPSC XXXXI, abstract #1533 [10] http://pds-imaging.jpl.nasa.gov/volumes/m3.html [11] Scholten et al. (2012) JGR 117, E00H17 [12] Pieters (1999) Workshop on New Views of the Moon II, abstract #8025 [13] Grumpe et al. (2013) Adv. Space Res., in press.

Berezhnoy, Alexey; Whler, Christian; Sinitsyn, Mikhail; Grumpe, Arne; Feoktistova, Ekaterina; Shevchenko, Vladislav

17

49 CFR Appendix C to Part 229 - FRA Locomotive Standards-Code of Defects  

Code of Federal Regulations, 2013 CFR

...2013-10-01 2013-10-01 false FRA Locomotive Standards-Code of Defects C...DEPARTMENT OF TRANSPORTATION RAILROAD LOCOMOTIVE SAFETY STANDARDS Pt. 229, App. C Appendix C to Part 229FRA Locomotive StandardsCode of Defects...

2013-10-01

18

49 CFR Appendix C to Part 229 - FRA Locomotive Standards-Code of Defects  

Code of Federal Regulations, 2011 CFR

...2011-10-01 2011-10-01 false FRA Locomotive Standards-Code of Defects C...DEPARTMENT OF TRANSPORTATION RAILROAD LOCOMOTIVE SAFETY STANDARDS Pt. 229, App. C Appendix C to Part 229FRA Locomotive StandardsCode of Defects...

2011-10-01

19

49 CFR Appendix C to Part 229 - FRA Locomotive Standards-Code of Defects  

Code of Federal Regulations, 2012 CFR

...2012-10-01 2012-10-01 false FRA Locomotive Standards-Code of Defects C...DEPARTMENT OF TRANSPORTATION RAILROAD LOCOMOTIVE SAFETY STANDARDS Pt. 229, App. C Appendix C to Part 229FRA Locomotive StandardsCode of Defects...

2012-10-01

20

49 CFR Appendix C to Part 229 - FRA Locomotive Standards-Code of Defects  

Code of Federal Regulations, 2010 CFR

...2010-10-01 2010-10-01 false FRA Locomotive Standards-Code of Defects C...DEPARTMENT OF TRANSPORTATION RAILROAD LOCOMOTIVE SAFETY STANDARDS Pt. 229, App. C Appendix C to Part 229FRA Locomotive StandardsCode of Defects...

2010-10-01

21

49 CFR 228.407 - Analysis of work schedules; submissions; FRA review and approval of submissions; fatigue...  

Code of Federal Regulations, 2012 CFR

...2012-10-01 2012-10-01 false Analysis of work schedules; submissions; FRA...Passenger Transportation 228.407 Analysis of work schedules; submissions; FRA...fatigue mitigation plans. (a) Analysis of work schedules. Each railroad...

2012-10-01

22

49 CFR 228.407 - Analysis of work schedules; submissions; FRA review and approval of submissions; fatigue...  

Code of Federal Regulations, 2013 CFR

...2013-10-01 2013-10-01 false Analysis of work schedules; submissions; FRA...Passenger Transportation 228.407 Analysis of work schedules; submissions; FRA...fatigue mitigation plans. (a) Analysis of work schedules. Each railroad...

2013-10-01

23

Circadian expression of transcription factor Fra-2 in the rat pineal gland.  

PubMed

Physiological changes in Fos-like immunoreactivity in the rat pineal gland are shown here to be due primarily to changes in a 42/46-kDa Fos-related antigen (Fra). Studies are presented that indicate this 42/46-kDa Fra is Fra-2, a poorly understood member of the Fos family of transcription factors. Both Fra-2 mRNA and protein are absent during the day and increase robustly at night on a circadian basis; organ culture studies indicate that regulation is mediated by an adrenergic-->cyclic AMP mechanism. AP-1 binding activity changes in parallel to changes in the level of Fra-2 protein. PMID:7592994

Baler, R; Klein, D C

1995-11-10

24

49 CFR 219.608 - FRA Administrator's determination of random alcohol testing rate.  

Code of Federal Regulations, 2010 CFR

... FRA Administrator's determination of random alcohol testing rate. 219.608 Section 219.608...ADMINISTRATION, DEPARTMENT OF TRANSPORTATION CONTROL OF ALCOHOL AND DRUG USE Random Alcohol and Drug Testing Programs 219.608...

2010-10-01

25

49 CFR 219.608 - FRA Administrator's determination of random alcohol testing rate.  

Code of Federal Regulations, 2011 CFR

... FRA Administrator's determination of random alcohol testing rate. 219.608 Section 219.608...ADMINISTRATION, DEPARTMENT OF TRANSPORTATION CONTROL OF ALCOHOL AND DRUG USE Random Alcohol and Drug Testing Programs 219.608...

2011-10-01

26

49 CFR 219.608 - FRA Administrator's determination of random alcohol testing rate.  

Code of Federal Regulations, 2012 CFR

... FRA Administrator's determination of random alcohol testing rate. 219.608 Section 219.608...ADMINISTRATION, DEPARTMENT OF TRANSPORTATION CONTROL OF ALCOHOL AND DRUG USE Random Alcohol and Drug Testing Programs 219.608...

2012-10-01

27

49 CFR 219.608 - FRA Administrator's determination of random alcohol testing rate.  

Code of Federal Regulations, 2013 CFR

... FRA Administrator's determination of random alcohol testing rate. 219.608 Section 219.608...ADMINISTRATION, DEPARTMENT OF TRANSPORTATION CONTROL OF ALCOHOL AND DRUG USE Random Alcohol and Drug Testing Programs 219.608...

2013-10-01

28

www.risoe.dk Forskningscenter Ris  

E-print Network

Meteorology Lars Landberg Aeroelastisk Design Flemming Rasmussen Wind turbines Peter Hjuler Jensen Risø Wind Wind turbine Testing Søren M Petersen Test & Measurements Søren M. Petersen Dept. Management ­ Standard dedicated offshore wind turbines #12;www.risoe.dk Wind Resources Kinetic Energyflux : P = ½U3 [W

29

From Filippo Lippi to Piero della Francesca: Fra Carnevale and the Making of a Renaissance Master  

NSDL National Science Digital Library

This special Web feature from the Metropolitan Museum centers around two fifteenth century paintings acquired by two US museums (the Metropolitan and the Museum of Fine Arts Boston) from the Barberini Collection in Rome in the 1930s, that have puzzled scholars for more than a century, and have only recently been identified as the work of Giovanni di Bartolomeo Corradini of Urbino, also known as Fra Carnevale. In addition to investigating the mystery of Fra Carnevale, the Web feature also examines the concepts of artistic identity, in contrast with the Renaissance practice of artworks that issue from the studio of a named artist, that are actually the work of many unnamed artists. To do this, the feature is divided into three sections: "Filippo Lippi", 29 works by Lippi and others trained in his workshop; "An Alternative Vision", seven paintings by artists working within the studio system, but, similar to Fra Carnevale's works, containing unusual elements; and "The Mystery of Fra Carnevale", including the two panels, most likely parts of Fra Carnevale's altarpiece for Santa Maria della Bella in Urbino, The Birth of the Virgin and The Presentation of the Virgin in the Temple, done in what has come to be recognized as Fra Carnevale's style-paintings so full of architectural details that the figures seem incidental to the architecture.

30

Fra-1 regulation of Matrix Metallopeptidase-1 (MMP-1) in metastatic variants of MDA-MB-231 breast cancer cells  

PubMed Central

Matrix Metallopeptidase 1 (MMP-1) expression has repeatedly been correlated to tumorigenesis and metastasis. Yet, MMP-1 regulation in a metastatic context remains largely unknown. Here we confirm differential MMP-1 expression in mammary carcinoma cells with varied metastatic potentials. We show that MMP-1 expression is regulated by an AP-1 element in its promoter in highly metastatic MDA-MB-231 mammary carcinoma cell derivatives. Fra-1, an AP-1 family transcription factor, differentially binds this element in highly metastatic cells compared to low metastatic cells and is required for MMP-1 expression. Overexpression of Fra-1 also caused increased MMP-1 expression. Fra-1 mRNA levels are unchanged in the cell variants, however its protein levels are higher in the metastatic cells. While there was no change in Fra-1 protein degradation rates, protein synthesis of Fra-1 was increased in the metastatic cell variant. These results demonstrate that Fra-1 and MMP-1 levels are differentially regulated in metastatic cell variants at the level of Fra-1 protein translation. Consistent with the importance of Fra-1 for tumor growth, we found that Fra-1 overexpression was sufficient to increase cell motility and anchorage independent growth. These results suggest that increased Fra-1 translation is critical for regulation of MMP-1 and tumor cell metastasis. PMID:25339983

Henckels, Eric; Prywes, Ron

2013-01-01

31

Oxidant-Induced Cell Death and Nrf2-Dependent Antioxidative Response Are Controlled by Fra-1/AP-1  

PubMed Central

AP-1 (Jun/Fos) transcription factors play key roles in various biological processes, including cell death. Here we report a novel role for Fra-1 in oxidant-induced cell death controlled by modulating antioxidant gene expression. Fra-1-deficient (Fra-1?/?) mouse embryonic fibroblasts (MEFs) and primary lung fibroblasts (PLFs) were remarkably resistant to H2O2- and diquat-induced cell death, compared to their wild-type (Fra-1+/+) counterparts. Fra-1 deficiency ablated oxidant-induced mitochondrion-dependent apoptosis. Fra-1?/? cells had elevated basal levels of antioxidant enzymes and intracellular glutathione (GSH), which were further stimulated by oxidants. Loss of Fra-1 led to an increased half-life of transcription factor Nrf2 and increased recruitment of this protein to the promoters of antioxidant genes and increased their expression. Depletion of intracellular GSH or RNA interference (RNAi)-mediated knockdown of Nqo1, Hmox1, and Nrf2 restored oxidant-induced cell death in Fra-1?/? cells. Thus, Fra-1 appears to increase susceptibility to oxidants and promotes cell death by attenuating Nrf2-driven antioxidant responses. PMID:22393254

Vaz, Michelle; Machireddy, Narsa; Irving, Ashley; Potteti, Haranatha R.; Chevalier, Karinne; Kalvakolanu, Dhananjaya

2012-01-01

32

Oxidant-induced cell death and Nrf2-dependent antioxidative response are controlled by Fra-1/AP-1.  

PubMed

AP-1 (Jun/Fos) transcription factors play key roles in various biological processes, including cell death. Here we report a novel role for Fra-1 in oxidant-induced cell death controlled by modulating antioxidant gene expression. Fra-1-deficient (Fra-1(?/?)) mouse embryonic fibroblasts (MEFs) and primary lung fibroblasts (PLFs) were remarkably resistant to H(2)O(2)- and diquat-induced cell death, compared to their wild-type (Fra-1(+/+)) counterparts. Fra-1 deficiency ablated oxidant-induced mitochondrion-dependent apoptosis. Fra-1(?/?) cells had elevated basal levels of antioxidant enzymes and intracellular glutathione (GSH), which were further stimulated by oxidants. Loss of Fra-1 led to an increased half-life of transcription factor Nrf2 and increased recruitment of this protein to the promoters of antioxidant genes and increased their expression. Depletion of intracellular GSH or RNA interference (RNAi)-mediated knockdown of Nqo1, Hmox1, and Nrf2 restored oxidant-induced cell death in Fra-1(?/?) cells. Thus, Fra-1 appears to increase susceptibility to oxidants and promotes cell death by attenuating Nrf2-driven antioxidant responses. PMID:22393254

Vaz, Michelle; Machireddy, Narsa; Irving, Ashley; Potteti, Haranatha R; Chevalier, Karinne; Kalvakolanu, Dhananjaya; Reddy, Sekhar P

2012-05-01

33

Fortsett snn! Samhandling ved utskrivning fra alderspsykiatrisk spesialisthelsetjeneste; Continue like that! Collaboration when old age psychiatry patients leave hospital.  

E-print Network

?? Hensikt: Hensikten med oppgaven har vrt underske om sykepleierapport, epikrise og dagens samhandlingspraksis ved utskrivning fra alderspsykiatrisk spesialisthelsetjeneste oppleves som nyttig av leger (more)

Nvik, Marit

2011-01-01

34

Selective induction of Fos and FRA immunoreactivity within the mesolimbic and mesostriatal dopamine terminal fields.  

PubMed

The influence of the mesencephalic dopaminergic projections on the neurons within the basal forebrain and prefrontal cortex is not well understood although it has been intensely investigated. The purpose of this study was to evaluate the expression of Fos-like and FRA-like (Fos Related Antigens) immunoreactivity (IR) as a qualitative and quantitative marker of neuronal activity within the mesolimbic and mesostriatal dopamine terminal fields. Following the administration of apomorphine (5.0 mg/kg S.C.), a rapid increase in FRA-IR, accompanied by Fos-IR, was observed within the striatum in a patchy distribution. Apomorphine also induced the expression of FRA-IR within the nucleus accumbens, cortex, septum, and the islands of Calleja complex. This broad pattern of activation contrasts with the limited expression of Fos-IR and FRA-IR within the dorsolateral striatum, dorsomedial shell of the nucleus accumbens, and cingulate cortex following haloperidol administration (2.0 mg/kg, S.C.). Finally, it was observed that nuclei expressed Fos-IR rapidly and transiently within the striatum following haloperidol, whereas the number of FRA-IR nuclei remained elevated but changed in distribution and intensity over time. In conclusion, different regions within the dopamine terminal fields express varying concentrations of Fos-IR and FRA-IR after stimulation or blockade of dopamine receptors. These data indicate that Fos, as well as selective FRAs, can be used to delineate populations of neurons with altered metabolic activity resulting from the administration of dopaminergic agents. Furthermore, the data support the concept of segregated mesostriatal and mesolimbic projections, in particular the division of the nucleus accumbens into the shell and core compartments. PMID:8497810

Dilts, R P; Helton, T E; McGinty, J F

1993-03-01

35

Expression profiling of genes regulated by Fra-1/AP-1 transcription factor during bleomycin-induced pulmonary fibrosis  

PubMed Central

Background The Fra-1/AP-1 transcription factor regulates the expression of genes controlling various processes including migration, invasion, and survival as well as extracellular remodeling. We recently demonstrated that loss of Fra-1 leads to exacerbated bleomycin-induced pulmonary fibrosis, accompanied by enhanced expression of various inflammatory and fibrotic genes. To better understand the molecular mechanisms by which Fra-1 confers protection during bleomycin-induced lung injury, genome-wide mRNA expression profiling was performed. Results We found that Fra-1 regulates gene expression programs that include: 1) several cytokines and chemokines involved in inflammation, 2) several genes involved in the extracellular remodeling and cell adhesion, and 3) several genes involved in programmed cell death. Conclusion Loss of Fra-1 leads to the enhanced expression of genes regulating inflammation and immune responses and decreased the expression of genes involved in apoptosis, suggesting that this transcription factor distinctly modulates early pro-fibrotic cellular responses. PMID:23758685

2013-01-01

36

Strling og Helse Vi lever i et hav av strling. Det er g-strling fra bakken, kosmisk strling ovenfra, radon i luften og radioaktiv-  

E-print Network

Stråling og Helse Vi lever i et hav av stråling. Det er g-stråling fra bakken, kosmisk stråling du kanskje flytte til et sted uten stråling? Radioaktivitet fra bakken Kosmisk stråling Radon radon og lungekreft) Radioaktivitet fra bakken Helt fra jorda ble dannet har det vært radioaktive

Sahay, Sundeep

37

Teststand plugin struktur til opsamling af data fra CompactDAQ chassis  

E-print Network

National Instruments produkterne Labview, Testand og DAQmx moduler. Der er udviklet i samarbejde med CIM brugervenligheden i test og målesystemer, hvor Labview og Teststand softwaren fra National Instruments benyttes førende firmaer indenfor Labview programmering i Norden, med 5 ud af de 27 certificerede Labview

38

Malinger af potentialbarrierer i en to dimensinal elektrongas stammende fra grfttsninger i  

E-print Network

M°alinger af potentialbarrierer i en to dimensinal elektrongas stammende fra grøftætsninger i . . . . . . . . . . . . . . . . . . . . . . . . . . . 26 7.2 M°aling af modstanden i 2DEGen uden barrierer . . . . . . . . . . 30 7.3 M°alinger af Richardsons lov . . . . . . . . . . . . . . . . . . . . . 35 7.4 Resultater af m°alinger p°a prøve C5

Nygård, Jesper

39

FRA2A Is a CGG Repeat Expansion Associated with Silencing of AFF3  

PubMed Central

Folate-sensitive fragile sites (FSFS) are a rare cytogenetically visible subset of dynamic mutations. Of the eight molecularly characterized FSFS, four are associated with intellectual disability (ID). Cytogenetic expression results from CGG tri-nucleotide-repeat expansion mutation associated with local CpG hypermethylation and transcriptional silencing. The best studied is the FRAXA site in the FMR1 gene, where large expansions cause fragile X syndrome, the most common inherited ID syndrome. Here we studied three families with FRA2A expression at 2q11 associated with a wide spectrum of neurodevelopmental phenotypes. We identified a polymorphic CGG repeat in a conserved, brain-active alternative promoter of the AFF3 gene, an autosomal homolog of the X-linked AFF2/FMR2 gene: Expansion of the AFF2 CGG repeat causes FRAXE ID. We found that FRA2A-expressing individuals have mosaic expansions of the AFF3 CGG repeat in the range of several hundred repeat units. Moreover, bisulfite sequencing and pyrosequencing both suggest AFF3 promoter hypermethylation. cSNP-analysis demonstrates monoallelic expression of the AFF3 gene in FRA2A carriers thus predicting that FRA2A expression results in functional haploinsufficiency for AFF3 at least in a subset of tissues. By whole-mount in situ hybridization the mouse AFF3 ortholog shows strong regional expression in the developing brain, somites and limb buds in 9.512.5dpc mouse embryos. Our data suggest that there may be an association between FRA2A and a delay in the acquisition of motor and language skills in the families studied here. However, additional cases are required to firmly establish a causal relationship. PMID:24763282

Metsu, Sofie; Rooms, Liesbeth; Rainger, Jacqueline; Taylor, Martin S.; Bengani, Hemant; Wilson, David I.; Chilamakuri, Chandra Sekhar Reddy; Morrison, Harris; Vandeweyer, Geert; Reyniers, Edwin; Douglas, Evelyn; Thompson, Geoffrey; Haan, Eric; Gecz, Jozef; FitzPatrick, David R.; Kooy, R. Frank

2014-01-01

40

49 CFR 229.207 - New locomotive crashworthiness design standards and changes to existing FRA-approved locomotive...  

Code of Federal Regulations, 2013 CFR

... 2013-10-01 false New locomotive crashworthiness design standards...changes to existing FRA-approved locomotive crashworthiness design standards...DEPARTMENT OF TRANSPORTATION RAILROAD LOCOMOTIVE SAFETY STANDARDS Locomotive...

2013-10-01

41

49 CFR 229.207 - New locomotive crashworthiness design standards and changes to existing FRA-approved locomotive...  

Code of Federal Regulations, 2010 CFR

... 2010-10-01 false New locomotive crashworthiness design standards...changes to existing FRA-approved locomotive crashworthiness design standards...DEPARTMENT OF TRANSPORTATION RAILROAD LOCOMOTIVE SAFETY STANDARDS Locomotive...

2010-10-01

42

49 CFR 229.207 - New locomotive crashworthiness design standards and changes to existing FRA-approved locomotive...  

Code of Federal Regulations, 2012 CFR

... 2012-10-01 false New locomotive crashworthiness design standards...changes to existing FRA-approved locomotive crashworthiness design standards...DEPARTMENT OF TRANSPORTATION RAILROAD LOCOMOTIVE SAFETY STANDARDS Locomotive...

2012-10-01

43

49 CFR 229.207 - New locomotive crashworthiness design standards and changes to existing FRA-approved locomotive...  

Code of Federal Regulations, 2011 CFR

... 2011-10-01 false New locomotive crashworthiness design standards...changes to existing FRA-approved locomotive crashworthiness design standards...DEPARTMENT OF TRANSPORTATION RAILROAD LOCOMOTIVE SAFETY STANDARDS Locomotive...

2011-10-01

44

UCSD\\/FRA non-contact ultrasonic guided-wave system for rail inspection: an update  

Microsoft Academic Search

The University of California at San Diego (UCSD), under a Federal Railroad Administration (FRA) Office of Research and Development (R&D) grant, is developing a system for high-speed and non-contact rail defect detection. A prototype has been designed and field tested with the support of Volpe National Transportation Systems Center and ENSCO, Inc. The goal of this project is to develop

Stefano Coccia; Robert Phillips; Claudio Nucera; Ivan Bartoli; Salvatore Salamone; Francesco Lanza di Scalea; Mahmood Fateh; Gary Carr

2011-01-01

45

FRA 3819 STAGE DANS UNE MAISON D'DITION Responsable du programme de 1er  

E-print Network

FRA 3819 STAGE DANS UNE MAISON D'?DITION Responsable du programme de 1er cycle 1. AVANT LE STAGE...) peuvent, à certaines conditions, se voir accorder un stage de trois crédits. La responsabilité de trouver un stage en édition et un responsable pour ce stage revient entièrement à l'étudiant. Le Département

Parrott, Lael

46

FRA 3860 STAGE EN MILIEU THTRAL Responsable du programme de 1er  

E-print Network

FRA 3860 STAGE EN MILIEU TH??TRAL Responsable du programme de 1er cycle 1. AVANT LE STAGE Ce stage trouver un stage en milieu théâtral et un responsable pour ce stage revient entièrement à l'étudiant. Le milieu théâtral. L'étudiant désireux de faire un stage et de se le voir crédité doit soumettre au

Parrott, Lael

47

Fra-1/AP-1 induces EMT in mammary epithelial cells by modulating Zeb1/2 and TGF? expression.  

PubMed

Epithelial-to-mesenchymal transition (EMT) is essential for embryonic morphogenesis and wound healing and critical for tumour cell invasion and dissemination. The AP-1 transcription factor Fra-1 has been implicated in tumorigenesis and in tumour-associated EMT in human breast cancer. We observed a significant inverse correlation between Fra-1 mRNA expression and distant-metastasis-free survival in a large cohort of breast cancer patients derived from multiple array data sets. This unique correlation among Fos genes prompted us to assess the evolutionary conservation between Fra-1 functions in EMT of human and mouse cells. Ectopic expression of Fra-1 in fully polarized, non-tumourigenic, mouse mammary epithelial EpH4 cells induced a mesenchymal phenotype, characterized by a loss of epithelial and gain of mesenchymal markers. Proliferation, motility and invasiveness were also increased in the resulting EpFra1 cells, and the cells were tumourigenic and efficiently colonized the lung upon transplantation. Molecular analyses revealed increased expression of Tgf?1 and the EMT-inducing transcription factors Zeb1, Zeb2 and Slug. Mechanistically, Fra-1 binds to the tgfb1 and zeb2 promoters and to an evolutionarily conserved region in the first intron of zeb1. Furthermore, increased activity of a zeb2 promoter reporter was detected in EpFra1 cells and shown to depend on AP-1-binding sites. Inhibiting TGF? signalling in EpFra1 cells moderately increased the expression of epithelial markers, whereas silencing of zeb1 or zeb2 restored the epithelial phenotype and decreased migration in vitro and tumorigenesis in vivo. Thus Fra-1 induces changes in the expression of genes encoding EMT-related transcription factors leading to the acquisition of mesenchymal, invasive and tumorigenic capacities by epithelial cells. This study defines a novel function of Fra-1/AP-1 in modulating tgfb1, zeb1 and zeb2 expression through direct binding to genomic regulatory regions, which establishes a basis for future in vivo genetic manipulations and preclinical studies using mouse models. PMID:25301070

Bakiri, L; Macho-Maschler, S; Custic, I; Niemiec, J; Guo-Carrin, A; Hasenfuss, S C; Eger, A; Mller, M; Beug, H; Wagner, E F

2015-02-01

48

The ICT SCRM CoMMunITy FRaMewoRk DevelopMenT pRojeCT  

E-print Network

The ICT SCRM CoMMunITy FRaMewoRk DevelopMenT pRojeCT FInal RepoRT The Supply Chain Management Technology (ICT). To support NIST's work, the Supply Chain Management Center of the Robert H. Smith School diverse ICT segments (software, hardware, networks and system integration services). It also formulated

49

Sedimentology of clastic rocks from the Fra Mauro region of the moon.  

NASA Technical Reports Server (NTRS)

A thin-section examination of sixteen clastic rock samples returned by the Apollo 14 mission from the Fra Mauro region of the moon suggests the presence of at least two distinctly different lithologies. Five of the samples (group I) are characterized by an abundant glassy matrix and glass particles and lesser amounts of plagioclase and pyroxene grains, and lithic clasts. The other eleven samples (group II) are relatively fine grained, very poorly sorted, and consist largely of pyroxene, plagioclase, and lithic clasts set in an abundant mineralic matrix. Group I and II lithologies were probably both deposited from impact generated base surges. The differences between them stem not as much from the basic sedimentary processes as from the differences in the magnitude of the events generating the base surges and the resultant difference in available detrital materials.

Lindsay, J. F.

1972-01-01

50

Rhinovirus-induced MMP-9 expression is dependent on Fra-1, which is modulated by formoterol and dexamethasone.  

PubMed

Matrix metalloproteinase-9 is implicated in airway inflammation and airway remodeling in asthma. We have previously confirmed that human rhinovirus-16 (HRV-16) infection increases MMP-9 expression both in vivo and in vitro. However, the role of the AP-1 sites within the MMP-9 promoter and the effect of commonly used asthma pharmacotherapies in modulating human rhinovirus (HRV)-induced MMP-9 production have not yet been elucidated. Experiments were performed in vitro in the human bronchial epithelial (HBE) cell line BEAS-2B and in primary HBE cells obtained from non-transplanted lungs. Using site-directed mutagenesis approaches, AP-1 sites were found to be necessary for HRV-induced MMP-9 promoter drive. EMSAs and supershift assays identified complexes consisting of Fos-related Ag-1 (Fra-1) in addition to other AP-1 subunits. Small interfering RNA approaches indicated that Fra-1 was induced upon HRV-16 infection in BEAS-2B cells and was necessary for MMP-9 expression in both BEAS-2B and primary HBE cells. Inhibition of MEK1/2 activity using PD98059 and U0126 reduced Fra-1 expression, DNA binding, MMP-9 promoter drive, and MMP-9 protein production. The long-acting ?(2)-agonist formoterol and the glucocorticoid dexamethasone significantly reduced HRV-induced ERK phosphorylation, Fra-1, and MMP-9 expression in BEAS-2B cells. These data indicate that HRV-induced activation of the MEK/ERK MAPK pathway and Fra-1 expression are necessary for the upregulation of MMP-9 and can be modulated by two distinct but commonly used asthma pharmacotherapies. Together, these results offer insights into the mechanisms by which long-acting ?(2)-agonists and glucocorticoids might reduce HRV-related asthma exacerbations. PMID:22461694

Tacon, Claire E; Newton, Robert; Proud, David; Leigh, Richard

2012-05-01

51

Rb-Sr ages of igneous rocks from the Apollo 14 mission and the age of the Fra Mauro formation.  

NASA Technical Reports Server (NTRS)

Internal Rb-Sr isochrons were determined on four basaltic rocks and on a basaltic clast from a breccia from the Fra Mauro landing site. An internal isochron was determined for rock 12004 and yielded a value in agreement with previous results for basaltic rocks from the Apollo 12 site. The crystallization ages for Apollo 14 basalts are only 0.2 to 0.3 AE older than were found for mare basalts from the Sea of Tranquility. Assuming these leucocratic igneous rocks to be representative of the Fra Mauro site, it follows that there were major igneous processes active in these regions, and presumably throughout the highlands, at times only slightly preceding the periods at which the maria were last flooded.

Papanastassiou, D. A.; Wasserburg, G. J.

1971-01-01

52

UCSD/FRA non-contact ultrasonic guided-wave system for rail inspection: an update  

NASA Astrophysics Data System (ADS)

The University of California at San Diego (UCSD), under a Federal Railroad Administration (FRA) Office of Research and Development (R&D) grant, is developing a system for high-speed and non-contact rail defect detection. A prototype has been designed and field tested with the support of Volpe National Transportation Systems Center and ENSCO, Inc. The goal of this project is to develop a rail defect detection system that provides (a) better defect detection reliability (including internal transverse head defects under shelling and vertical split head defects), and (b) higher inspection speed than achievable by current rail inspection systems. This effort is also in direct response to Safety Recommendations issued by the National Transportation Safety Board (NTSB) following the disastrous train derailments at Superior, WI in 1992 and Oneida, NY in 2007 among others. The UCSD prototype uses non-contact ultrasonic probing of the rail head (laser and air-coupled), ultrasonic guided waves, and a proprietary real-time statistical analysis algorithm that maximizes the sensitivity to defects while minimizing false positives. The current design allows potential inspection speeds up to 40 mph, although all field tests have been conducted up to 15 mph so far. This paper summarizes (a) the latest technology development test conducted at the rail defect farm of Herzog, Inc. in St Joseph, MO in June 2010, and (b) the completion of the new Rail Defect Farm facility at the UCSD Camp Elliott Field Station with partial in-kind donations from the Burlington Northern Santa Fe (BNSF) Railway.

Coccia, Stefano; Phillips, Robert; Nucera, Claudio; Bartoli, Ivan; Salamone, Salvatore; Lanza di Scalea, Francesco; Fateh, Mahmood; Carr, Gary

2011-04-01

53

Neoplastic transformation of rat thyroid cells requires the junB and fra-1 gene induction which is dependent on the HMGI-C gene product.  

PubMed Central

The expression of the high mobility group I (HMGI)-C chromatin component was shown previously to be essential for the establishment of the neoplastic phenotype in retrovirally transformed thyroid cell lines. To identify possible targets of the HMGI-C gene product, we have analyzed the AP-1 complex in normal, fully transformed and antisense HMGI-C-expressing rat thyroid cells. We show that neoplastic transformation is associated with a drastic increase in AP-1 activity, which reflects multiple compositional changes. The strongest effect is represented by the dramatic junB and fra-1 gene induction, which is prevented in cell lines expressing the antisense HMGI-C. These results indicate that the HMGI-C gene product is essential for the junB and fra-1 transcriptional induction associated with neoplastic transformation. The inhibition of Fra-1 protein synthesis by stable transfection with a fra-1 antisense RNA vector significantly reduces the malignant phenotype of the transformed thyroid cells, indicating a pivotal role for the fra-1 gene product in the process of cellular transformation. PMID:9311991

Vallone, D; Battista, S; Pierantoni, G M; Fedele, M; Casalino, L; Santoro, M; Viglietto, G; Fusco, A; Verde, P

1997-01-01

54

Reverse mapping of the gene encoding the human fos-related antigen-1 (fra-1) within chromosome band 11q13  

SciTech Connect

For the identification of sequence-tagged sites within cosmid clones derived from the q13 region of human chromosome 11, the authors subcloned a number of single copy BamHI fragments in a pT7T3 19U vector. Surprisingly, within one of these subclones, they encountered a stretch of DNA that matches perfectly with 5' end of the known cDNA sequence for the human fos-related antigen. This match comes to an abrupt end at nucleotide 328, which coincides with a perfect splice donor site. At position 231 an ATG codon (translation initiation) was found. From these data they conclude that position 328 marks the boundary of the first exon of the fra-1 gene. Homology of this same region with the rat fra-1 cDNA sequence is [+-]70%. This human fra-1 genomic fragment is contained within cosmid clone cCL11-254 (D11S460), which was previously mapped to region V of a long-range contig map of 11q13. The localization of fra-1 on chromosome 11 was cross-checked and confirmed by hybridizing the fra-1 containing fragment to a panel of somatic cell hybrids, including one line that contains chromosome 11 as its only human constituent. In addition to a cross-hybridizing rodent fragment, a single human-specific band was revealed in all the chromosome 11-containing hybrids. This subchromosomal localization of fra-1 to 11q13 adds yet another proto-oncogene to this restricted genomic region, which appears to be involved in a number of neoplastic disorders, e.g., multiple endocrine neoplasia type 1, breast cancer, squamous cell tumors of head and neck, esophageal carcinoma, hepatocellular carcinoma, melanoma, bladder carcinoma, extragonadal germ cell tumors, and some hematopoietic malignancies. 7 refs., 1 fig.

Sinke, R.J. (University Hospital, Nijmegen (Netherlands)); Tanigami, A.; Nakamura, Y.; Kessel, A.G. van (Cancer Institute, Tokyo (Japan))

1993-10-01

55

Adaptive Flexibility in the Foraging Behavior of Fishes' Simon Fra.~erUniversity, Departsnent of Biological Sciences, Bui-naby, B.C. V5A IS6  

E-print Network

Adaptive Flexibility in the Foraging Behavior of Fishes' Simon Fra.~erUniversity, Departsnent of fishes. Can. 5. Fish. Aquat. Sci. 40: 398-408. Flexibility is an important adaptive feature of Biological Sciences, Bui-naby, B.C. V5A IS6 DILL,L. M. 1983. Adaptive flexibility in the foraging behavior

Dill, Lawrence M.

56

Chagas disease-specific antigens: characterization of epitopes in CRA/FRA by synthetic peptide mapping and evaluation by ELISA-peptide assay  

PubMed Central

Background The identification of epitopes in proteins recognized by medically relevant antibodies is useful for the development of peptide-based diagnostics and vaccines. In this study, epitopes in the cytoplasmic repetitive antigen (CRA) and flagellar repetitive antigen (FRA) proteins from Trypanosoma cruzi were identified using synthetic peptide techniques and pooled sera from Chagasic patients. The epitopes were further assayed with an ELISA assay based on synthetic peptides. Methods Twenty-two overlapping synthetic peptides representing the coding sequence of the T. cruzi CRA and FRA proteins were assessed by a Spot-synthesis array analysis using sera donated by patients with Chagas disease. Shorter peptides were selected that represented the determined epitopes and synthesized by solid phase synthesis to evaluate the patterns of cross-reactivities and discrimination through an ELISA-diagnostic assay. Results The peptide Spot-synthesis array successfully identified two IgG antigenic determinants in the CRA protein and four in FRA. Bioinformatics suggested that the CRA antigens were unique to T. cruzi while the FRA antigen showed similarity with sequences present within various proteins from Leishmania sp. Subsequently, shorter peptides representing the CRA-1, CRA-2 and FRA-1 epitopes were synthesized by solid phase synthesis and assayed by an ELISA-diagnostic assay. The CRA antigens gave a high discrimination between Chagasic, Leishmaniasis and T. cruzi-uninfected serum. A sensitivity and specificity of 100% was calculated for CRA. While the FRA antigen showed a slightly lower sensitivity (91.6%), its specificity was only 60%. Conclusions The epitopes recognized by human anti-T. cruzi antibodies have been precisely located in two biomarkers of T. cruzi, CRA and FRA. The results from screening a panel of patient sera through an ELISA assay based on peptides representing these epitopes strongly suggest that the sequences from CRA would be useful for the development of diagnostic reagents that could improve upon the sensitivity and specificity of currently available diagnostic tests. Overall, the results provide further evidence of the usefulness of identifying specific linear B-cell epitopes for improving diagnostic tools. PMID:24299278

2013-01-01

57

WWOX, the common fragile site FRA16D gene product, regulates ATM activation and the DNA damage response.  

PubMed

Genomic instability is a hallmark of cancer. The WW domain-containing oxidoreductase (WWOX) is a tumor suppressor spanning the common chromosomal fragile site FRA16D. Here, we report a direct role of WWOX in DNA damage response (DDR) and DNA repair. We show that Wwox deficiency results in reduced activation of the ataxia telangiectasia-mutated (ATM) checkpoint kinase, inefficient induction and maintenance of ?-H2AX foci, and impaired DNA repair. Mechanistically, we show that, upon DNA damage, WWOX accumulates in the cell nucleus, where it interacts with ATM and enhances its activation. Nuclear accumulation of WWOX is regulated by its K63-linked ubiquitination at lysine residue 274, which is mediated by the E3 ubiquitin ligase ITCH. These findings identify a novel role for the tumor suppressor WWOX and show that loss of WWOX expression may drive genomic instability and provide an advantage for clonal expansion of neoplastic cells. PMID:25331887

Abu-Odeh, Mohammad; Salah, Zaidoun; Herbel, Christoph; Hofmann, Thomas G; Aqeilan, Rami I

2014-11-01

58

In quest of lunar regolith breccias of exotic provenance - A uniquely anorthositic sample from the Fra Mauro (Apollo 14) highlands  

NASA Technical Reports Server (NTRS)

Bulk compositions of 21 Apollo regolith breccias were determined using an INAA procedure modified from that of Kallemeyn et al. (1989). With one major exception, namely, the 14076,1 sample, the regolith breccias analyzed were found to be not significantly different from the surfaces from which they were collected. In contrast, the 14076,1 sample from the Fra Mauro (Apollo 14) region is a highly anorthositic regolith breccia from a site where anorthosites are extremely scarce. The sample's composition resembles soils from the Descartes (Apollo 16) highlands. However, the low statistical probability for long-distance horizontal transport by impact cratering, together with the relatively high contents of imcompatible elements in 14076,1 suggest that this regolith breccia originated within a few hundred kilometers of the Apollo 14 site. Its compositional resemblance to ferroan anorthosite strengthens the hypothesis that ferroan anorthosite originated as the flotation crust of a global magmasphere.

Jerde, Eric A.; Warren, Paul H.; Morris, Richard V.

1990-01-01

59

Common Chromosome Fragile Sites in Human and Murine Epithelial Cells and FHIT/FRA3B Loss-Induced Global Genome Instability  

PubMed Central

Chromosomal positions of common fragile sites differ in lymphoblasts and fibroblasts, with positions dependent on the epigenetically determined density of replication origins at these loci. Because rearrangement of fragile loci and associated loss of fragile gene products are hallmarks of cancers, we aimed to map common fragile sites in epithelial cells, from which most cancers derive. Among the five most frequently activated sites in human epithelial cells were chromosome bands 2q33 and Xq22.1, which are not among top fragile sites identified in lymphoblasts or fibroblasts. FRA16D at 16q23 was among the top three fragile sites in the human epithelial cells examined, as it is in lymphoblasts and fibroblasts, while FRA3B at 3p14.2, the top fragile locus in lymphoblasts, was not fragile in most epithelial cell lines tested. Epithelial cells exhibited varying hierarchies of fragile sites; some frequent epithelial cell fragile sites are apparently not frequently altered in epithelial cancers and sites that are frequently deleted in epithelial cancers are not necessarily among the most fragile. Since we have reported that loss of expression of the FRA3B-encoded FHIT protein causes increased replication stress-induced DNA damage, we also examined the effect of FHIT-deficiency on markers of genome instability in epithelial cells. FHIT-deficient cells exhibited increases in fragile breaks and in ?H2AX and 53BP1 foci in G1 phase cells, confirming in epithelial cells that the FHIT gene and encompassing FRA3B, is a caretaker gene necessary for maintenance of genome stability. PMID:23929738

Hosseini, Seyed Ali; Horton, Susan; Saldivar, Joshua C.; Miuma, Satoshi; Stampfer, Martha R.; Heerema, Nyla A.; Huebner, Kay

2015-01-01

60

Sources of clasts in terrestrial impact melts - Clues to the origin of LKFM. [Low-K Fra Mauro  

NASA Technical Reports Server (NTRS)

Low-K Fra Mauro (LKFM) 'basalt', which is found exclusively as an impact melt rock, cannot be modeled geochemically from its clast population or from any combination of known pristine lunar rock types. To clarify clast/melt relationships, a study was made of impact melt rocks from Mistastin Lake crater, Labrador, where there are only three target rocks: anorthosite, quartz monzonite, and granodiorite. Feldspar compositions in these rocks define distinct fields on the An-Ab-Or ternary diagram, making it possible to identify the source of each feldspar clast. Clasts in the Mistastin impact melts do not reflect the abundance of target rocks melted during the impact. The abundance of anorthosite in the clast population varies from 34 to 100 percent compared to a relatively constant value of 65 percent calculated to be in the melt matrix. Therefore the clasts appear to be derived predominantly from material relatively far removed from the zone of impact melting. Melt-matrix composition is dictated strictly by the composition of the target materials within a small radius around and below the point of impact. This suggests that the LKFM composition was derived from a lower crustal source.

Mccormick, K. A.; Taylor, G. J.; Keil, K.; Spudis, P. D.; Grieve, R. A. F.

1989-01-01

61

NYT................................................. FRA BJERGET  

E-print Network

. Natural science, too, leapt forward with enormous strides. The emergence of new theories and ideas by instincts, indeed, by sexuality, and the pursuit of natural laws revealed unexplored areas of enormous. It ,,contains its enemy within,"Z) as Ihab Hassan says, and evokes what it wishes to surpass. However, where

Paris-Sud XI, Université de

62

LOXL4 Is Induced by Transforming Growth Factor ?1 through Smad and JunB/Fra2 and Contributes to Vascular Matrix Remodeling  

PubMed Central

Transforming growth factor ?1 (TGF-?1) is a pleiotropic factor involved in the regulation of extracellular matrix (ECM) synthesis and remodeling. In search for novel genes mediating the action of TGF-?1 on vascular ECM, we identified the member of the lysyl oxidase family of matrix-remodeling enzymes, lysyl oxidase-like 4 (LOXL4), as a direct target of TGF-?1 in aortic endothelial cells, and we dissected the molecular mechanism of its induction. Deletion mapping and mutagenesis analysis of the LOXL4 promoter demonstrated the absolute requirement of a distal enhancer containing an activator protein 1 (AP-1) site and a Smad binding element for TGF-?1 to induce LOXL4 expression. Functional cooperation between Smad proteins and the AP-1 complex composed of JunB/Fra2 accounted for the action of TGF-?1, which involved the extracellular signal-regulated kinase (ERK)-dependent phosphorylation of Fra2. We furthermore provide evidence that LOXL4 was extracellularly secreted and significantly contributed to ECM deposition and assembly. These results suggest that TGF-?1-dependent expression of LOXL4 plays a role in vascular ECM homeostasis, contributing to vascular processes associated with ECM remodeling and fibrosis. PMID:23572561

Busnadiego, Oscar; Gonzlez-Santamara, Jos; Lagares, David; Guinea-Viniegra, Juan; Pichol-Thievend, Cathy; Muller, Laurent

2013-01-01

63

Brndselscellers fysik og kemi Anders Smith og Mogens Mogensen, Afdelingen for Materialeforskning, Forskningscenter Ris.  

E-print Network

. For alle typer er bruttoreaktionen den samme: 2H2 + O2 2H2O + elek- tricitet + varme. (eng. "Molten Carbonate Fuel Cell", MCFC) og endelig fastoxidbrændselscellen (eng. "Solid Oxide Fuel Cell", SOFC), som har

64

Monitoring thermal stresses and incipient buckling of continuous-welded rails: results from the UCSD/BNSF/FRA large-scale laboratory test track  

NASA Astrophysics Data System (ADS)

Most modern railways use Continuous Welded Rail (CWR). A major problem is the almost total absence of expansion joints that can create buckling in hot weather and breakage in cold weather due to the rail thermal stresses. In June 2008 the University of California, San Diego (UCSD), under the sponsorship of a Federal Railroad Administration (FRA) Office of Research and Development (R&D) grant, began work to develop a technique for in-situ measurement of stress and detection of incipient buckling in CWR. The method under investigation is based on ultrasonic guided waves, and the ultimate goal is to develop a prototype that can be used in motion. A large-scale full rail track (70 feet in length) has been constructed at UCSD's Powell Structural Laboratories, the largest laboratories in the country for structural testing, to validate the CWR stress measurement and buckling detection technique under rail heating conditions well controlled in the laboratory. This paper will report on the results obtained from this unique large-scale test track to date. These results will pave the road for the future development of the rail stress measurement & buckling detection prototype.

Phillips, Robert; Nucera, Claudio; Coccia, Stefano; Lanza di Scalea, Francesco; Bartoli, Ivan; Fateh, Mahmood; Carr, Gary

2011-04-01

65

In Situ Proximity Ligation Detection of c-Jun/AP-1 Dimers Reveals Increased Levels of c-Jun/Fra1 Complexes in Aggressive Breast Cancer Cell Lines in Vitro and in Vivo*  

PubMed Central

Genetic and biochemical studies have shown that selective interactions between the Jun, Fos, and activating transcription factor (ATF) components of transcription factor activating protein 1 (AP-1) exhibit specific and critical functions in the regulation of cell proliferation, differentiation, and survival. For instance, the ratio between c-Jun/c-Fos and c-Jun/ATF2 dimers in the cell can be a determining factor in the cellular response to oncogenic or apoptotic stimuli. Until recently, no methods were available to detect endogenous AP-1 complexes in cells and tissues in situ. Here, we validated the proximity ligation assay (PLA) for its ability to specifically visualize and quantify changes in endogenous c-Jun/c-Fos, c-Jun/ATF2, and c-Jun/Fra1 complexes by using, among others, partner-selective c-Jun mutants. Furthermore, we examined the levels of c-Jun/AP-1 dimers in cell lines representing different types of human breast cancer and found that aggressive basal-like breast cancer cells can be discriminated from much less invasive luminal-like cells by PLA detection of c-Jun/Fra1 rather than of c-Jun/ATF2 and c-Jun/c-Fos. Also in tumor tissue derived from highly metastatic basal-like MDA-MB231 cells, high levels of c-Jun/Fra1 complexes were detected. Together, these results demonstrate that in situ PLA is a powerful diagnostic tool to analyze and quantify the amounts of biologically critical AP-1 dimers in fixed cells and tissue material. PMID:20511396

Baan, Bart; Pardali, Evangelia; ten Dijke, Peter; van Dam, Hans

2010-01-01

66

The group-based social skills training SOSTA-FRA in children and adolescents with high functioning autism spectrum disorder - study protocol of the randomised, multi-centre controlled SOSTA - net trial  

PubMed Central

Background Group-based social skills training (SST) has repeatedly been recommended as treatment of choice in high-functioning autism spectrum disorder (HFASD). To date, no sufficiently powered randomised controlled trial has been performed to establish efficacy and safety of SST in children and adolescents with HFASD. In this randomised, multi-centre, controlled trial with 220 children and adolescents with HFASD it is hypothesized, that add-on group-based SST using the 12 weeks manualised SOSTAFRA program will result in improved social responsiveness (measured by the parent rated social responsiveness scale, SRS) compared to treatment as usual (TAU). It is further expected, that parent and self reported anxiety and depressive symptoms will decline and pro-social behaviour will increase in the treatment group. A neurophysiological study in the Frankfurt HFASD subgroup will be performed pre- and post treatment to assess changes in neural function induced by SST versus TAU. Methods/design The SOSTA net trial is designed as a prospective, randomised, multi-centre, controlled trial with two parallel groups. The primary outcome is change in SRS score directly after the intervention and at 3 months follow-up. Several secondary outcome measures are also obtained. The target sample consists of 220 individuals with ASD, included at the six study centres. Discussion This study is currently one of the largest trials on SST in children and adolescents with HFASD worldwide. Compared to recent randomised controlled studies, our study shows several advantages with regard to in- and exclusion criteria, study methods, and the therapeutic approach chosen, which can be easily implemented in non-university-based clinical settings. Trial registration ISRCTN94863788 SOSTA net: Group-based social skills training in children and adolescents with high functioning autism spectrum disorder. PMID:23289935

2013-01-01

67

Afprvning af leverance af reguleringsydelser fra et  

E-print Network

dieselgenerator som (en stor del af) batteri- installationer elimineres. I tilgift fås et UPS system, der arbejder anlæg baseret på · 80 kW mikrogasturbine · UPS/inverter system · Absorption Chiller system UPS/inverter system #12;· Tilslutning for absorptionskøleanlæg · Evt. interface for styring/dialog med

68

La rivalit fra Lo Surdo e Fermi  

Microsoft Academic Search

\\u000a Nella vulgata della scuola di fisica romana degli anni Trenta Antonino Lo Surdo viene presentato come un professore antiquato,\\u000a ostile a Fermi e ad alcuni suoi giovani collaboratori, di carattere freddo e invidioso. Questi giudizi negativi si basano\\u000a sulle testimonianze scritte di Emilio Segr, uno dei pi brillanti allievi e collaboratori di Enrico Fermi, premio Nobel per\\u000a la Fisica nel

Franco Foresta Martin; Geppi Calcara

69

Sponsored Programs Administration Financial Research Administrators (FRA's) Assignments  

E-print Network

Studies Diana Markham CHHS Health Management & Policy Diana Markham CHHS Institute for Health Policy and Campus Planning All Diana Markham Information Technology All Kathy Mason Paul College All Erin Selner Research Animal Resource Office Erin Selner Research EPSCoR Erin Selner Research Interoperability Lab Erin

New Hampshire, University of

70

Lokationsbaseret styring af logistiske processer med optimerede sensordata fra smartphones  

E-print Network

Kandidatspeciale i Software Engineering Rapporten er skrevet af: Jacob Flygenring Vejleder(e): Ekkart Kindler-point. Rettigheder © Jacob Flygenring, 2011 #12;Jeg vil gerne takke de mennesker, der har hjulpet med at skrive denne Morten Krastins for deres særligt store indsats. Også Anne Riis og Torben Flygenring har været til

71

49 CFR Appendix C to Part 241 - Geographical Boundaries of FRA's Regions and Addresses of FRA's Regional Headquarters  

Code of Federal Regulations, 2012 CFR

...Rhode Island, Connecticut, and New Jersey. The mailing address of the Regional Headquarters is: 55 Broadway, Room 1077, Cambridge, Massachusetts 02142. The fax number is 617-494-2967. The electronic mail (E-mail) address of the Regional...

2012-10-01

72

49 CFR Appendix C to Part 241 - Geographical Boundaries of FRA's Regions and Addresses of FRA's Regional Headquarters  

Code of Federal Regulations, 2013 CFR

...Rhode Island, Connecticut, and New Jersey. The mailing address of the Regional Headquarters is: 55 Broadway, Room 1077, Cambridge, Massachusetts 02142. The fax number is 617-494-2967. The electronic mail (E-mail) address of the Regional...

2013-10-01

73

49 CFR Appendix C to Part 241 - Geographical Boundaries of FRA's Regions and Addresses of FRA's Regional Headquarters  

Code of Federal Regulations, 2010 CFR

...Dakota, and Alaska. The mailing address of the Regional Headquarters is: Murdock Executive Plaza, 703 Broadway, Suite 650, Vancouver, Washington 98660. The fax number is 360-696-7548. The E-mail address of the Regional Administrator for Region...

2010-10-01

74

49 CFR Appendix C to Part 241 - Geographical Boundaries of FRA's Regions and Addresses of FRA's Regional Headquarters  

Code of Federal Regulations, 2011 CFR

...Dakota, and Alaska. The mailing address of the Regional Headquarters is: Murdock Executive Plaza, 703 Broadway, Suite 650, Vancouver, Washington 98660. The fax number is 360-696-7548. The E-mail address of the Regional Administrator for Region...

2011-10-01

75

Ris-R-1595(DA) Evaluering af rapporteringssystemet  

E-print Network

Sundhedsvæsen Henning Boje Andersen, Verner Andersen og Kristine Beisner Forskningscenter Risø Danmarks Tekniske Universitet Roskilde Januar 2007 #12;Forfattere: Henning Boje Andersen, Verner Andersen og Kristine Beisner

76

Fluviale kanaler fra et stort vre kretassisk delta ved Pautfit, Vestgr~nland; sandlegemegeometri og kanalmorfologi  

Microsoft Academic Search

(. san, shale and coal seams are here very well exposed in a series of steep sided gullies. The investigations were focused on an analysis of the sand-body geometry and the fluvial style of the different types af channels. The use of an advanced photogrammetric system during the investigations enabled the construction of precise vertical sections of the exposures, which

TORBEN OLSEN

77

Exposure ages and neutron capture record in lunar samples from Fra Mauro.  

NASA Technical Reports Server (NTRS)

Cosmic-ray exposure ages of Apollo 14 rocks and rock fragments obtained by the Kr81-Kr83 method range from 27 to 700 m.y. Rock 14321, collected near the Cone crater rim, is one of the many approximately 27 m.y. old ejecta which were reported at the Third Lunar Science Conference. All the other rocks have considerably higher exposure ages. Isotopic anomalies from neutron capture in gadolinium, bromine, and barium are used to obtain information on the lunar neutron spectrum at various depths below the lunar surface. The flux ratio of resonance and slow (less than 0.3 eV) neutrons is found to be nearly constant in the topmost approximately 100 g/sq cm.

Lugmair, G. W.; Marti, K.

1972-01-01

78

Oncogene . Author manuscript The PKC pathway participates in the aberrant accumulation of Fra-1  

E-print Network

Oncogene . Author manuscript Page /1 13 The PKC pathway participates in the aberrant accumulation-Serine-Threonine Kinases ; metabolism ; Proto-Oncogene Proteins c-fos ; metabolism ; Receptors, Estrogen ; metabolism

Paris-Sud XI, Université de

79

49 CFR 219.602 - FRA Administrator's determination of random drug testing rate.  

Code of Federal Regulations, 2012 CFR

...annual percentage rate for random drug testing is based on the reported...determination is drawn from the drug MIS reports required by this part. In order to ensure reliability of...annual percentage rate for random drug testing of covered...

2012-10-01

80

49 CFR 219.602 - FRA Administrator's determination of random drug testing rate.  

Code of Federal Regulations, 2011 CFR

...annual percentage rate for random drug testing is based on the reported...determination is drawn from the drug MIS reports required by this part. In order to ensure reliability of...annual percentage rate for random drug testing of covered...

2011-10-01

81

49 CFR 219.602 - FRA Administrator's determination of random drug testing rate.  

Code of Federal Regulations, 2010 CFR

...annual percentage rate for random drug testing is based on the reported...determination is drawn from the drug MIS reports required by this part. In order to ensure reliability of...annual percentage rate for random drug testing of covered...

2010-10-01

82

49 CFR 219.602 - FRA Administrator's determination of random drug testing rate.  

Code of Federal Regulations, 2013 CFR

...annual percentage rate for random drug testing is based on the reported...determination is drawn from the drug MIS reports required by this part. In order to ensure reliability of...annual percentage rate for random drug testing of covered...

2013-10-01

83

Sulla relazione fra la teoria di Tomonaga-Schwinger e quella di Dirac-Fock-Podolsky  

Microsoft Academic Search

RiassuntoSi dimostra, mediante una opportuna estensione covariante di un metodo proposto daBecker eLeibfried, che, per particelle tutte di un solo tipo, la teoria di Dirac-Fock-Podolsky equivalente a una formulazione della teoria\\u000a di Tomonaga-Schwinger relativa ad un numero finito di particelle.

P. Bocchieri; A. Loinger

1955-01-01

84

"Speech Act" Fra Teoria e Prassi Didattica. (The Speech Act between Theory and Pedagogical Practice).  

ERIC Educational Resources Information Center

The author traces the development of speech act theory from Wittgenstein and Austin through Searle to Grice and shows how their work led to the notional functional approach to language teaching, which is based on the learner and his/her communicative needs. (CFM)

Minardi, Giovanni

1982-01-01

85

Solvarmeanlg fra Batec Solvarme A/S, Velux Danmark A/S og SONNENKRAFT Scandinavia  

E-print Network

Danmark A/S og Sonnenkraft Scandinavia A/S. Rapporten afslutter energiforskningsprojektet EFP07 blive videreført i 2009 i forskningsprojektet EFP07-II, Solvarmeanlægs energibesparelser, fase 2, hvor

86

Fri prosjektsttte: Nye prosjekter innenfor matematikk, naturvitenskap og teknologi (FRINATEK) fra 2014 Prosjekt Tittel Prosjektansvarlig  

E-print Network

-structure interaction in the upper airways Institutt for energi- og prosessteknikk, Norges Teknisk- Naturvitenskapelige (EME) Farmasøytisk institutt, Universitetet i Oslo 231741 Modeling of obstructive sleep apnea by fluid

Brandenburg, Axel

87

Lunar surface closeup stereoscopic photography at Fra Mauro (Apollo 14 site)  

NASA Technical Reports Server (NTRS)

A total of 17-1/2 stereopairs of lunar surface rocks and soil was taken on the Apollo 14 mission. The closeup stereopair photographs are presented with a preliminary interpretation for those interested in lunar soil formation, impact phenomena, and soil mechanics.

Carrier, W. D., III; Heiken, G.

1972-01-01

88

Paraje (de Fra Cristobal): investigations of a Territorial period Hispanic village site in southern New Mexico  

E-print Network

. 1857 map of a portion of southern New Mexico. . 58 63 Figure 5. 5. Map of Fort Craig and vicinity in February, 1862. . . . 7Z Figure 5. 6. Rio Grande area south of Fort Craig in 1869. . Figure 5. 7. 1877 map of the Paraje area 92 Figure 5. 8... into New Mexico. They were not interested in scholarly studies of Hi spanic culture but in establishing a foothold for business enterprises. Some early Anglos in New Mexico, like Josiah Gregg (1933), William W. H. Davis (1938), and Charles Lummis (1893...

Boyd, Douglas Kevin

2012-06-07

89

-Forty Years of Research in a Changing Society Henry Nielsen  

E-print Network

, Aarhus University Keld Nielsen, the Danish Museum of Electricity Flemming Petersen, the Danish Museum years ago... ...was one of the largest, single investments in Danish research. The intention. The result was a book in Danish entitled Til samfundets tarv - Forskningscenter Risøs historie by Henry

90

Komedikasjon av statiner og CYP3A34-hemmere i Norge : En legemiddelepidemiologisk studie med data fra Reseptregisteret.  

E-print Network

??Sammendrag Bakgrunn Hemming av cytokrom P450 (CYP) enzymer, spesielt CYP3A4, er en viktig mekanisme bak legemiddelinteraksjoner. HMG-CoA reduktase hemmere (statiner) brukes mye i behandling av (more)

Devold, Helene Margrethe

2007-01-01

91

Corporate governance, risk management e responsabilit sociale fra presente e futuro dellattivit di internal auditing  

Microsoft Academic Search

Negli studi pi recenti condotti sullinternal auditing si evidenzia come, in un numero via via maggiore di aziende, il raggio di azione di tale funzione tenda ad estendersi dalle tradizionali attivit di compliance e di revisione gestionale alla verifica dei sistemi di corporate governance e di gestione dei rischi. Alcuni studiosi ritengono, inoltre, che nei prossimi anni, gli internal auditor

Marco Allegrini; Giuseppe DOnza

2011-01-01

92

49 CFR 228.407 - Analysis of work schedules; submissions; FRA review and approval of submissions; fatigue...  

Code of Federal Regulations, 2011 CFR

...train employees who work the schedule may be at risk of experiencing a...this section as at risk, including potential...caused by unscheduled work assignments. Compliance...railroad's review of work schedules found to be at risk for a level of...

2011-10-01

93

Hvad er tilfldet? og Hvad ligger der bag? De to sociologier og samfundsteorien  

Microsoft Academic Search

Siden begyndelsen af sin akademiske karriere har sociologien nrmet sig sin genstand p to forskellige mder: dels med en positivistisk og dels med en kritisk indstilling. Vigtige teorierssom Karl Marx' og Emile Durkheimshar alle foretrukket den ene side af denne forskel, men har ikke derved kunnet ignorere den anden. Som empirisk videnskab har sociologien udviklet en interesse for latente strukturer.

Niklas Luhmann

2000-01-01

94

Yersinia pestis pFra Shows Biovar-Specific Differences and Recent Common Ancestry with a Salmonella enterica Serovar Typhi Plasmid  

Microsoft Academic Search

Population genetic studies suggest that Yersinia pestis, the cause of plague, is a clonal pathogen that has recently emerged from Yersinia pseudotuberculosis. Plasmid acquisition is likely to have been a key element in this evolutionary leap from an enteric to a flea-transmitted systemic pathogen. However, the origin of Y. pestis-specific plasmids remains obscure. We demonstrate specific plasmid rearrangements in different

MICHAEL B. PRENTICE; KEITH D. JAMES; JULIAN PARKHILL; STEPHEN G. BAKER; KIM STEVENS; MARK N. SIMMONDS; KAREN L. MUNGALL; CAROL CHURCHER; PETRA C. F. OYSTON; RICHARD W. TITBALL; BRENDAN W. WREN; JOHN WAIN; DEREK PICKARD; TRAN TINH HIEN; JEREMY J. FARRAR; GORDON DOUGAN

2001-01-01

95

49 CFR Appendix F to Part 236 - Minimum Requirements of FRA Directed Independent Third-Party Assessment of PTC System Safety...  

Code of Federal Regulations, 2011 CFR

...as a representative number sufficient to provide confidence that all unaudited modules were developed in compliance...estimates for the PTC system, and the supplier's confidence interval in these estimates; (2) PTC system...

2011-10-01

96

49 CFR Appendix F to Part 236 - Minimum Requirements of FRA Directed Independent Third-Party Assessment of PTC System Safety...  

Code of Federal Regulations, 2010 CFR

...as a representative number sufficient to provide confidence that all unaudited modules were developed in compliance...estimates for the PTC system, and the supplier's confidence interval in these estimates; (2) PTC system...

2010-10-01

97

Projektarbejde i fremmedsprogene: Rapport fra seminar pa Roskilde Universitetscenter (Project Work in Foreign Languages: Report from a Seminar at Roskilde University Center). ROLIG-papir 38.  

ERIC Educational Resources Information Center

This report describes a seminar at Roskilde University Center (Denmark) on project work in foreign languages, which brought together language teachers and theorists from different schools, including universities, business schools, technical schools, merchants schools, and high schools, to discuss their experiences with project work in foreign

Jakobsen, Karen Sonne, Ed.

98

Petrogenesis of the western highlands of the moon - Evidence from a diverse group of whitlockite-rich rocks from the Fra Mauro formation  

NASA Technical Reports Server (NTRS)

A group of KREEPy basalts has been discovered in Apollo 14 soils. These samples exhibit similarities to both HA and VHK basalts, albeit with much higher REE abundances, and contain up to 2 vol pct whitlockite and can be explained by assimilation of a K-, REE- and P-rich fluids by an original HA or VHK basalt. This KREEP component could have been produced late in the evolution of the lunar magma ocean and is similar in composition to QMD at Apollo 14. Two rocks have trace element compositions that are representative of actual KREEP. One of the samples appears to be petrographically pristine and could represent an actual KREEP basalt rock. Five subophitic high-Al basalts represent sampling of either a slowly cooled impact melt sheet or, more likely, the same basalt flow. Two 'quasi-pristine' highland rocks confirm the postulate of a connection between KREEP and the alkali suite. A newly discovered alkali anorthosite is a plagioclase cumulate with about 15 percent trapped KREEPy liquid.

Snyder, Gregory A.; Taylor, Lawrence A.; Liu, Yun-Gang; Schmitt, Roman A.

1992-01-01

99

49 CFR Appendix B to Part 221 - Approved Rear End Marking Devices  

Code of Federal Regulations, 2012 CFR

...for or by manufacturers 1. Manufacturer: Star Headlight & Lantern Co., 168 West Main Street...14472. FRA identification Nos. FRA-PLE-STAR-845-F (flasher) and FRA-PLE-STAR-845-C (steady burn). 2....

2012-10-01

100

49 CFR Appendix B to Part 221 - Approved Rear End Marking Devices  

Code of Federal Regulations, 2013 CFR

...for or by manufacturers 1. Manufacturer: Star Headlight & Lantern Co., 168 West Main Street...14472. FRA identification Nos. FRA-PLE-STAR-845-F (flasher) and FRA-PLE-STAR-845-C (steady burn). 2....

2013-10-01

101

49 CFR Appendix B to Part 221 - Approved Rear End Marking Devices  

Code of Federal Regulations, 2010 CFR

...for or by manufacturers 1. Manufacturer: Star Headlight & Lantern Co., 168 West Main Street...14472. FRA identification Nos. FRA-PLE-STAR-845-F (flasher) and FRA-PLE-STAR-845-C (steady burn). 2....

2010-10-01

102

49 CFR Appendix B to Part 221 - Approved Rear End Marking Devices  

Code of Federal Regulations, 2011 CFR

...for or by manufacturers 1. Manufacturer: Star Headlight & Lantern Co., 168 West Main Street...14472. FRA identification Nos. FRA-PLE-STAR-845-F (flasher) and FRA-PLE-STAR-845-C (steady burn). 2....

2011-10-01

103

75 FR 27053 - Railroad Safety Advisory Committee; Charter Renewal  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF TRANSPORTATION Federal Railroad Administration [Docket No. FRA-2000-7257; Notice No. 61] Railroad Safety Advisory Committee; Charter Renewal AGENCY: Federal Railroad Administration (FRA), Department of...

2010-05-13

104

75 FR 15484 - Railroad Safety Technology Program Grant Program  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF TRANSPORTATION Federal Railroad Administration [Docket No. FRA-2010-005-N-5] Railroad Safety Technology Program Grant Program AGENCY: Federal Railroad Administration (FRA), Department of...

2010-03-29

105

77 FR 28421 - Railroad Safety Advisory Committee; Charter Renewal  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF TRANSPORTATION Federal Railroad Administration [Docket No. FRA-2000-7257: Notice No. 70] Railroad Safety Advisory Committee; Charter Renewal AGENCY: Federal Railroad Administration (FRA), Department of...

2012-05-14

106

78 FR 66987 - Railroad Safety Technology Program Grant Program  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF TRANSPORTATION Federal Railroad Administration [Docket No. FRA-2010-005-N-5] Railroad Safety Technology Program Grant Program AGENCY: Federal Railroad Administration (FRA), Department of...

2013-11-07

107

Cluster of Genes That Encode Positive and Negative Elements Influencing Filament Length in a Heterocyst-Forming Cyanobacterium  

PubMed Central

The filamentous, heterocyst-forming cyanobacteria perform oxygenic photosynthesis in vegetative cells and nitrogen fixation in heterocysts, and their filaments can be hundreds of cells long. In the model heterocyst-forming cyanobacterium Anabaena sp. strain PCC 7120, the genes in the fraC-fraD-fraE operon are required for filament integrity mainly under conditions of nitrogen deprivation. The fraC operon transcript partially overlaps gene all2395, which lies in the opposite DNA strand and ends 1 bp beyond fraE. Gene all2395 produces transcripts of 1.35 kb (major transcript) and 2.2 kb (minor transcript) that overlap fraE and whose expression is dependent on the N-control transcription factor NtcA. Insertion of a gene cassette containing transcriptional terminators between fraE and all2395 prevented production of the antisense RNAs and resulted in an increased length of the cyanobacterial filaments. Deletion of all2395 resulted in a larger increase of filament length and in impaired growth, mainly under N2-fixing conditions and specifically on solid medium. We denote all2395 the fraF gene, which encodes a protein restricting filament length. A FraF-green fluorescent protein (GFP) fusion protein accumulated significantly in heterocysts. Similar to some heterocyst differentiation-related proteins such as HglK, HetL, and PatL, FraF is a pentapeptide repeat protein. We conclude that the fraC-fraD-fraE?fraF gene cluster (where the arrow indicates a change in orientation), in which cis antisense RNAs are produced, regulates morphology by encoding proteins that influence positively (FraC, FraD, FraE) or negatively (FraF) the length of the filament mainly under conditions of nitrogen deprivation. This gene cluster is often conserved in heterocyst-forming cyanobacteria. PMID:23813733

Merino-Puerto, Victoria; Herrero, Antonia

2013-01-01

108

Dette bachelorprojekt er udarbejdet p baggrund af mlinger foretaget ved Nano-Science Center p H. C. rsteds Instituttet i perioden fra d. 7. februar til d. 31. marts 2003.  

E-print Network

.3 Probestation 15 3.4 ?tsning 15 3.5 Bonding 15 3.6 Atomic Force Microscope (AFM) 16 3.7 Elektrisk måleopstilling-dimensionelt grafitlag (graphene sheet), selvom det ikke sådan, de fremstilles. Deres egenskaber kan derfor

Nygård, Jesper

109

Dall'italo-austrliano all'italiano: apprendmento linguistico fra gli scolari della seconda generazione (From Italian-Australian to Italian: Language Acquisition among the Students of the Second Generation).  

ERIC Educational Resources Information Center

Discusses the results of research to determine the success of the efforts currently being made in schools to teach pure Italian to the second generation of Italians in Australia in order to replace Italian Australian, a mixture of Italian dialects, Italian, and English. 33 references. (CFM)

Rubino, Antonia

1989-01-01

110

Organisk geokjemi og foraminiferfauna i midtre til vre jura p Haltenbanken, med vekt p avsetningsmiljet.  

E-print Network

??I dette hovedfagsarbeidet gir en stratigrafisk oversikt og faciestolkning av Melke- og Spekkformasjonen fra brnn 6507/7-5, basert p foraminiferanalyser kombinert med data fra organisk geokjemi, (more)

Grnseth, Ole Tom

2004-01-01

111

75 FR 44046 - Railroad Safety Advisory Committee; Notice of Meeting  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF TRANSPORTATION Federal Railroad Administration [Docket No. FRA-2000-7257; Notice No. 62] Railroad Safety Advisory Committee; Notice of Meeting AGENCY: Federal Railroad Administration (FRA), Department of...

2010-07-27

112

75 FR 3959 - Railroad Safety Advisory Committee; Notice of Meeting  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF TRANSPORTATION Federal Railroad Administration [Docket No. FRA-2000-7257; Notice No. 58] Railroad Safety Advisory Committee; Notice of Meeting AGENCY: Federal Railroad Administration (FRA), Department of...

2010-01-25

113

76 FR 67020 - Railroad Safety Advisory Committee; Notice of Meeting  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF TRANSPORTATION Federal Railroad Administration [Docket No. FRA-2000-7257; Notice No. 67] Railroad Safety Advisory Committee; Notice of Meeting AGENCY: Federal Railroad Administration (FRA), Department of...

2011-10-28

114

75 FR 44051 - Resolicitation of Applications for the Railroad Safety Technology Program Grant Program (RS-TEC...  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF TRANSPORTATION Federal Railroad Administration [Docket No. FRA-2010-005-N-5...Resolicitation of Applications for the Railroad Safety Technology Program Grant Program (RS-TEC-10-001) AGENCY: Federal Railroad Administration (FRA), Department...

2010-07-27

115

78 FR 71708 - Notification of Application for Approval of a Railroad Safety Program Plan  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF TRANSPORTATION Federal Railroad Administration [Docket Number FRA-2011-0026...Notification of Application for Approval of a Railroad Safety Program Plan In accordance with...Island Rail Road petitioned the Federal Railroad Administration (FRA) for approval...

2013-11-29

116

77 FR 52393 - Railroad Safety Advisory Committee; Notice of Meeting  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF TRANSPORTATION Federal Railroad Administration [Docket No. FRA-2000-7257Notice No. 69] Railroad Safety Advisory Committee; Notice of Meeting AGENCY: Federal Railroad Administration (FRA), Department of...

2012-08-29

117

75 FR 73158 - Railroad Safety Advisory Committee; Notice of Meeting  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF TRANSPORTATION Federal Railroad Administration [Docket No. FRA-2000-7257; Notice No. 64] Railroad Safety Advisory Committee; Notice of Meeting AGENCY: Federal Railroad Administration (FRA), Department of...

2010-11-29

118

78 FR 42998 - Hazardous Materials: Improving the Safety of Railroad Transportation of Hazardous Materials  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF TRANSPORTATION Federal Railroad Administration [Docket No. FRA-2013-0067...Hazardous Materials: Improving the Safety of Railroad Transportation of Hazardous Materials...Safety Administration (PHMSA), Federal Railroad Administration (FRA), Department...

2013-07-18

119

78 FR 48931 - Railroad Safety Advisory Committee; Notice of Emergency Meeting  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF TRANSPORTATION Federal Railroad Administration [Docket No. FRA-2000-7257; Notice No. 75] Railroad Safety Advisory Committee; Notice of Emergency Meeting AGENCY: Federal Railroad Administration (FRA), Department...

2013-08-12

120

78 FR 59754 - Notice of Application for Approval of Railroad Safety Program Plan and Product Safety Plan  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF TRANSPORTATION Federal Railroad Administration [Docket Number FRA-2013-0088...Notice of Application for Approval of Railroad Safety Program Plan and Product Safety...Railway (ATN) petitioned the Federal Railroad Administration (FRA) for approval...

2013-09-27

121

77 FR 77183 - Railroad Safety Advisory Committee; Notice of Meeting Postponement  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF TRANSPORTATION Federal Railroad Administration [Docket No. FRA-2000-7257; Notice No. 73] Railroad Safety Advisory Committee; Notice of Meeting Postponement AGENCY: Federal Railroad Administration (FRA), Department...

2012-12-31

122

78 FR 71709 - Notice of Application for Approval of Discontinuance or Modification of a Railroad Signal System  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF TRANSPORTATION Federal Railroad Administration [Docket Number FRA-2013-0111...of Discontinuance or Modification of a Railroad Signal System In accordance with part...Transportation (CSX) petitioned the Federal Railroad Administration (FRA) seeking...

2013-11-29

123

76 FR 27171 - Northwestern Pacific Railroad Co.; Notice of Partial Relief from Emergency Order No. 21  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF TRANSPORTATION Federal Railroad Administration [FRA Emergency Order...Notice No. 4] Northwestern Pacific Railroad Co.; Notice of Partial Relief...Emergency Order No. 21 AGENCY: Federal Railroad Administration (FRA),...

2011-05-10

124

78 FR 62002 - Railroad Safety Advisory Committee; Notice of Meeting  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF TRANSPORTATION Federal Railroad Administration [Docket No. FRA-2000-7257; Notice No. 76] Railroad Safety Advisory Committee; Notice of Meeting AGENCY: Federal Railroad Administration (FRA), Department of...

2013-10-10

125

78 FR 26423 - Railroad Safety Advisory Committee; Notice of Meeting  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF TRANSPORTATION Federal Railroad Administration [Docket No. FRA-2000-7257: Notice No. 74] Railroad Safety Advisory Committee; Notice of Meeting AGENCY: Federal Railroad Administration (FRA), Department of...

2013-05-06

126

76 FR 24561 - Railroad Safety Advisory Committee; Notice of Meeting  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF TRANSPORTATION Federal Railroad Administration [Docket No. FRA-2000-7257; Notice No. 66] Railroad Safety Advisory Committee; Notice of Meeting AGENCY: Federal Railroad Administration (FRA), Department of...

2011-05-02

127

77 FR 19054 - Railroad Safety Advisory Committee; Notice of Meeting  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF TRANSPORTATION Federal Railroad Administration [Docket No. FRA-2000-7257; Notice No. 68] Railroad Safety Advisory Committee; Notice of Meeting AGENCY: Federal Railroad Administration (FRA), Department of...

2012-03-29

128

75 FR 8788 - Railroad Safety Advisory Committee; Notice of Meeting  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF TRANSPORTATION Federal Railroad Administration [Docket No. FRA-2000-7257; Notice No. 60] Railroad Safety Advisory Committee; Notice of Meeting AGENCY: Federal Railroad Administration (FRA), Department of...

2010-02-25

129

78 FR 68147 - Notice of Application for Approval of Discontinuance or Modification of a Railroad Signal System  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF TRANSPORTATION Federal Railroad Administration [Docket Number FRA-2013-0110...of Discontinuance or Modification of a Railroad Signal System In accordance with Part...Transportation (CSX) petitioned the Federal Railroad Administration (FRA) seeking...

2013-11-13

130

77 FR 73734 - Railroad Safety Advisory Committee; Notice of Meeting  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF TRANSPORTATION Federal Railroad Administration [Docket No. FRA-2000-7257; Notice No. 72] Railroad Safety Advisory Committee; Notice of Meeting AGENCY: Federal Railroad Administration (FRA), Department of...

2012-12-11

131

75 FR 11992 - Notice of Scheduling of Public Hearing; Association of American Railroads  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF TRANSPORTATION Federal Railroad Administration [Docket Number FRA-2009-0111...Public Hearing; Association of American Railroads In a notice published January 4, 2010, the Federal Railroad Administration (FRA) announced...

2010-03-12

132

75 FR 81710 - Proposed Agency Information Collection Activities; Comment Request  

Federal Register 2010, 2011, 2012, 2013

...OF TRANSPORTATION Federal Railroad Administration [Docket No...information is used by FRA, railroad employees, rescue workers...emergency, such as a collision, derailment, explosion, fire, or some...FRA inspectors to monitor railroads' regulatory compliance...

2010-12-28

133

78 FR 21185 - Petition for Amending Waiver of Compliance  

Federal Register 2010, 2011, 2012, 2013

...has petitioned the Federal Railroad Administration (FRA) for...provisions of the Federal railroad safety regulations contained...reporting employee and the railroad from punitive sanctions that...events involving damage or derailment below the FRA monetary...

2013-04-09

134

76 FR 78730 - Petition for Waiver of Compliance  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF TRANSPORTATION Federal Railroad Administration [Docket Number FRA-2011-0085...notice is hereby given that the Federal Railroad Administration (FRA) has received a...4\\ crossties has not resulted in any derailments due to gage or crossties defects in...

2011-12-19

135

75 FR 63889 - Proposed Agency Information Collection Activities; Comment Request  

Federal Register 2010, 2011, 2012, 2013

...OF TRANSPORTATION Federal Railroad Administration [Docket No...information is used by FRA, railroad employees, rescue workers...emergency, such as a collision, derailment, explosion, fire, or some...FRA inspectors to monitor railroads' regulatory compliance...

2010-10-18

136

78 FR 25347 - Petition for Amending Waiver of Compliance  

Federal Register 2010, 2011, 2012, 2013

...has petitioned the Federal Railroad Administration (FRA) for...provisions of the Federal railroad safety regulations contained...reporting employees and the railroad from punitive sanctions that...events involving damage or derailment below the FRA monetary...

2013-04-30

137

78 FR 69745 - Safety and Security Plans for Class 3 Hazardous Materials Transported by Rail  

Federal Register 2010, 2011, 2012, 2013

...Administration (PHMSA) and Federal Railroad Administration (FRA), Department...6, 2013, a catastrophic railroad accident occurred in Lac-M...subsequently derailed. The derailment resulted in multiple explosions...Joint Advisory to FRA's Railroad Safety Advisory...

2013-11-20

138

78 FR 1934 - Petition for Waiver of Compliance  

Federal Register 2010, 2011, 2012, 2013

...part 223 (Safety Glazing Standards--Locomotives, Passenger Cars and Cabooses). FRA...permanent waiver of compliance for two locomotives, SIND 103 and SIND 104, from the requirements...223.11--Requirements for existing locomotives, which requires FRA Type I...

2013-01-09

139

77 FR 30047 - Petition for Alternative Locomotive Crashworthiness Design  

Federal Register 2010, 2011, 2012, 2013

...FRA-2012-0036] Petition for Alternative Locomotive Crashworthiness Design In accordance with...Administration (FRA) for approval of alternative locomotive crashworthiness design for an electric locomotive, Model ACS-64, built by Siemens...

2012-05-21

140

77 FR 69923 - Petition for Waiver of Compliance  

Federal Register 2010, 2011, 2012, 2013

...223--Safety Glazing Standards-- Locomotives, Passenger Cars and Cabooses. FRA...223.11--Requirements for existing locomotives and 49 CFR 223.13--Requirements...petitioned FRA for a waiver for one American Locomotive Company Model S-4,...

2012-11-21

141

49 CFR 225.31 - Investigations.  

Code of Federal Regulations, 2010 CFR

... Investigations. (a) It is the policy of the FRA to investigate rail transportation accidents/incidents which result...railroad safety. (b) FRA representatives are authorized to investigate accidents/incidents and have been issued...

2010-10-01

142

Year by year progression for a student in a major or a minor (depending on the entry level) / Progression par anne pour un tudiant inscrit dans une majeure ou une mineure  

E-print Network

Year by year progression for a student in a major or a minor (depending on the entry level French II (optional to continue to FRA courses) EDU105 Introduction to Linguistics for Language Teaching contemporain FRA250 French Cinema #12;FRA254 Littérature et cinéma en France FRA255 Littérature et cinéma au

143

Sequence conservation at human and mouse orthologous common fragile regions,  

E-print Network

orthologous to the fragile epicenter of FRA3B, and determined the Fhit deletion break points in a mouse kidney). Deletions and structural rearrangements in FRA3B have been observed in a large fraction of tumor types. The tumor sup- presser gene FHIT encompasses the FRA3B fragile region and is altered by deletion

Miller, Webb

144

Hunting on land and at sea and fishing in Medieval Norse Greenland  

Microsoft Academic Search

Forfatteren forsger ? ud fra de eksisterende kilder: de skriftlige, og de zoologiske og arkologiske fund fra udgravninger af nordbogrde i Grnland at fastsl, at jagt, bde til lands og til vands, og fiskeri, har vret en vsentlig del af grundlaget for de norrne beboeres eksistens i middelalderens Grnland. Forf. gr ? ud fra de gjorte fund, og her srligt

C. L. Vebk

1991-01-01

145

76 FR 34801 - Petition for Modification of Single Car Air Brake Test Procedures  

Federal Register 2010, 2011, 2012, 2013

...FRA-2010-0174] Petition for Modification of Single Car Air Brake Test Procedures In accordance...FRA) grant a modification of the single car air brake test procedures as prescribed...FRA-2010-0174. PATH operates a fleet of 25 flat cars in consist with revenue cars utilized...

2011-06-14

146

Aberrant Neural Function during Emotion Attribution in Female Subjects with Fragile X Syndrome  

ERIC Educational Resources Information Center

The neurobiological systems which underlie emotion attribution among female patients with Fragile X (FraX) syndrome are examined. Results show that the emotion circuit which regulates responses to facial stimuli is potentially disrupted among female subjects with FraX syndrome. Anterior cingulate cortex activity in female subjects with FraX

Hagan, Cindy C.; Hoeft, Fumiko; Mackey, Allyson; Mobbs, Dean; Reiss, Allan L.

2008-01-01

147

Discrimination of the spectral structures of sound signals on the background of interference  

Microsoft Academic Search

Presentation of test signals consisting of sounds with rippled spectra allowed measurements of the frequency-resolving ability\\u000a (FRA) of hearing to be performed in humans without using frequency-dependent masking techniques. This allowed studies of changes\\u000a in FRA in the presence of noise interference. In conditions of diotic presentation (to both ears in parallel) of the test\\u000a signal and noise, FRA decreased

A. Ya. Supin

2008-01-01

148

ERK-MAPK signaling coordinately regulates activity of Rac1 and RhoA for tumor cell motility  

Microsoft Academic Search

We describe two signaling events downstream of ERK-MAP kinase contributing to cell motility in colon carcinoma cells. The Fos family member Fra-1 is expressed in an ERK-dependent manner. Silencing of Fra-1 expression with short interfering RNAs leads to losses of cell polarization, motility, and invasiveness in vitro. These effects of ablating Fra-1 are a consequence of activation of a RhoA-ROCK

Emmanuel Vial; Erik Sahai; Christopher J. Marshall

2003-01-01

149

75 FR 20038 - Railroad Safety Technology Grant Program  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF TRANSPORTATION Federal Railroad Administration [Docket No. FRA-2010-005-N-5] Railroad Safety Technology Grant Program AGENCY: Federal Railroad Administration, Department of Transportation....

2010-04-16

150

75 FR 65707 - Notice Regarding Consideration and Processing of Applications for Financial Assistance Under the...  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF TRANSPORTATION Federal Railroad Administration Notice Regarding...for Financial Assistance Under the Railroad Rehabilitation and Improvement Financing...RRIF) Program AGENCY: Federal Railroad Administration (FRA),...

2010-10-26

151

76 FR 18623 - Notification of Petition for Approval; Railroad Safety Program Plan  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF TRANSPORTATION Federal Railroad Administration Notification of Petition for Approval; Railroad Safety Program Plan Although not required, the Federal Railroad Administration (FRA) is providing notice that it...

2011-04-04

152

77 FR 22381 - Odorant Fade in Railroad Tank Cars  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF TRANSPORTATION Federal Railroad Administration [Safety Advisory 2012-01] Odorant Fade in Railroad Tank Cars AGENCY: Federal Railroad Administration (FRA), Department of Transportation...

2012-04-13

153

75 FR 60165 - Notice Regarding Consideration and Processing of Applications for Financial Assistance Under the...  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF TRANSPORTATION Federal Railroad Administration Notice Regarding...for Financial Assistance Under the Railroad Rehabilitation and Improvement Financing...RRIF) Program AGENCY: Federal Railroad Administration (FRA),...

2010-09-29

154

75 FR 26843 - Notification of Petition for Approval; Railroad Safety Program Plan  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF TRANSPORTATION Federal Railroad Administration Notification of Petition for Approval; Railroad Safety Program Plan Although not required, the Federal Railroad Administration (FRA) is providing notice that it...

2010-05-12

155

Et introduksjonskurs EndNote X6 introduksjon Liv Brynhild Aspaas og Jo Forthun -NTNU UB, jan. 2013 2  

E-print Network

..................................................................................................................................... 11 Eksempel 3: ISI Web of Science.................................................................................................................................. 19 EndNote Web (http://myendnoteweb.com/) ............................................................................ 20 Eks) Fra ISI Web of Science til EndNote Web

Malinnikova, Eugenia

156

Bioteknologien og Frankenstein Dag O. Hessen  

E-print Network

etterkrigstiden; det var Aldous Huxleys Brave New World fra 1932, og George Orwells 1984 fra 1949. Den første var sannhetsrelativisering og en bølge av "new age"-fenomener, som oftest ikledd naturvitenskapens språkdrakt. Barnet ble

Hessen, Dag Olav

157

49 CFR Appendix B to Part 240 - Procedures for Submission and Approval of Locomotive Engineer Qualification Programs  

Code of Federal Regulations, 2013 CFR

...the railroad is not obligated to submit information on how the previously untrained will...periodically. Each railroad needs to advise FRA how that need is satisfied in terms...matter of particular concern to FRA is how each railroad acts to...

2013-10-01

158

77 FR 53164 - Railroad Workplace Safety; Adjacent-Track On-Track Safety for Roadway Workers  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF TRANSPORTATION Federal Railroad Administration 49 CFR Part 214 [Docket...FRA-2008-0059, Notice No. 6] RIN 2130-AC37 Railroad Workplace Safety; Adjacent-Track On-Track...for Roadway Workers AGENCY: Federal Railroad Administration (FRA), Department...

2012-08-31

159

77 FR 13978 - Railroad Workplace Safety; Adjacent-Track On-Track Safety for Roadway Workers  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF TRANSPORTATION Federal Railroad Administration 49 CFR Part 214 [Docket...FRA-2008-0059, Notice No. 5] RIN 2130-AB96 Railroad Workplace Safety; Adjacent-Track On-Track...for Roadway Workers AGENCY: Federal Railroad Administration (FRA), Department...

2012-03-08

160

78 FR 33754 - Railroad Workplace Safety; Adjacent-Track On-Track Safety for Roadway Workers  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF TRANSPORTATION Federal Railroad Administration 49 CFR Part 214 [Docket...FRA-2008-0059, Notice No. 7] RIN 2130-AC37 Railroad Workplace Safety; Adjacent-Track On-Track...for Roadway Workers AGENCY: Federal Railroad Administration (FRA), Department...

2013-06-05

161

Improving freight rail safety with on-board monitoring and control systems  

Microsoft Academic Search

The Office of Research and Development of the Federal Railroad Administration (FRA) is sponsoring a revenue service demonstration of Advanced Train Systems to demonstrate new technologies for improving safety and efficiency in freight train operations. The project, which commenced in 1999, is part of the Rolling Stock Program Element in FRA's Five-Year Strategic Plan for Railroad Research, Development and Demonstrations.

M. C. Edwards; W. M. Zavis; A. Prabhakaran; D. C. Brabb; A. S. Jackson

2005-01-01

162

Prof. Dr. Ir. Joost-Pieter Katoen Prof. em. Dr. Klaus Indermark  

E-print Network

Staff · Faculty Prof. Dr. Ir. Joost-Pieter Katoen Prof. em. Dr. Klaus Indermark apl. Prof. Dr Bundeswehr München, GER) B. Srivathsan (LaBRI, Bordeaux, FRA) Daniel Stan (ENS Cachan, FRA) Gerjan Stokkink of post-doctoral research. Dino Distefano was one of the first PhD stu- dents supervised by Joost

Ábrahám, Erika

163

49 CFR 209.105 - Notice of probable violation.  

Code of Federal Regulations, 2012 CFR

...FRA may change the civil penalty amount proposed to be assessed up to and including the maximum penalty amount of $55,000 for each...if the violation results in death, serious illness or severe...property, FRA may change the penalty amount proposed to be...

2012-10-01

164

49 CFR 209.105 - Notice of probable violation.  

Code of Federal Regulations, 2013 CFR

...FRA may change the civil penalty amount proposed to be assessed up to and including the maximum penalty amount of $75,000 for each...if the violation results in death, serious illness or severe...property, FRA may change the penalty amount proposed to be...

2013-10-01

165

49 CFR 209.105 - Notice of probable violation.  

Code of Federal Regulations, 2011 CFR

...FRA may change the civil penalty amount proposed to be assessed up to and including the maximum penalty amount of $55,000 for each...if the violation results in death, serious illness or severe...property, FRA may change the penalty amount proposed to be...

2011-10-01

166

49 CFR 209.105 - Notice of probable violation.  

Code of Federal Regulations, 2010 CFR

...FRA may change the civil penalty amount proposed to be assessed up to and including the maximum penalty amount of $55,000 for each...if the violation results in death, serious illness or severe...property, FRA may change the penalty amount proposed to be...

2010-10-01

167

77 FR 23159 - Locomotive Safety Standards; Correction  

Federal Register 2010, 2011, 2012, 2013

...FR-2009-0095, Notice No. 4] RIN 2130-AC16 Locomotive Safety Standards; Correction AGENCY...that the correct docket number for the Locomotive Safety Standards final rule is FRA-2009-0094...FRA published a final rule related to locomotive safety standards. See 77 FR...

2012-04-18

168

76 FR 8699 - Locomotive Safety Standards; Correction  

Federal Register 2010, 2011, 2012, 2013

...FRA-2009-0095, Notice No. 2] RIN 2130-AC16 Locomotive Safety Standards; Correction AGENCY...that the correct docket number for the Locomotive Safety Standards notice of proposed...2011, FRA published an NPRM related to locomotive safety standards. See 76 FR...

2011-02-15

169

76 FR 19518 - Safety Advisory 2011-01  

Federal Register 2010, 2011, 2012, 2013

...Railroad Administration Safety Advisory 2011-01 AGENCY: Federal Railroad Administration...FRA is issuing Safety Advisory 2011-01 to remind each railroad and railroad employees...FRA may modify this Safety Advisory 2011-01, issue additional safety advisories,...

2011-04-07

170

Rail-car impact tests with steel coil: car crush  

Microsoft Academic Search

Two grade-crossing impact tests were conducted in June 2002 at the Federal Railroad Administration's (FRA's) Transportation Technology Center in Pueblo, Colorado as part of the FRA's research into passenger equipment crashworthiness. In both of these tests a cab car moving at approximately 14 mph impacted a standing coil of steel supported by a frangible table. The coil was positioned such

Eloy Martinez; David Tyrell; John Zolock

2003-01-01

171

75 FR 76256 - Amendments to Regulations Regarding Withdrawal of Applications and Voluntary Suspension of Benefits  

Federal Register 2010, 2011, 2012, 2013

...Workers choose when to apply for old-age benefits. Workers who apply for old-age benefits at FRA will receive...payments after FRA. Workers who live to their average life expectancies...reconsider their having applied for old-age benefits. Continued...

2010-12-08

172

Reorganization of Receptive Fields Following Hearing Loss in Inferior Colliculus Neurons  

PubMed Central

We explored frequency and intensity encoding in the inferior colliculus of the C57 mouse model of sensorineural hearing loss. Consistent with plasticity reported in the IC of other models of hearing loss, frequency response areas (FRAs) in hearing impaired (HI) mice were broader with fewer high-frequency units than normal-hearing (NH) mice. The broad FRAs recorded from HI mice had lower cutoffs on the low frequency edge of the FRA. Characteristic frequency (CF) and sharpness of tuning (Q10) calculated from the FRA were used to divide the sample into 4 categories: low-CF sharp-FRA, low-CF broad-FRA, high-CF sharp-FRA, and high-CF broad-FRA units. Rate-intensity functions (RIFs) for CF tones and noise were used to determine the minimum and maximum response counts as well as the sound pressure levels resulting in 10%, 50%, and 90% of the maximum spike count. Tone RIFs of broad FRA units were shifted to the right of tone RIFs of sharp FRA units in both NH and HI mouse IC, regardless of the unit CF. The main effects of hearing loss were seen in the noise RIFs. The low-CF broad-FRA units in HI mice had elevated response to noise, and the high-CF sharp-FRA units in HI mice had lower maximum rates, as compared to the units recorded from NH mice. These results suggest that, as the IC responds to peripheral hearing loss with changes in the representation of frequency, an altered balance between inhibitory and excitatory inputs to the neurons recorded from the HI mice alter aspects of the units intensity encoding. This altered balance likely occurs, at least in part, outside of the IC. PMID:17540507

Barsz, Kathy; Wilson, Willard W.; Walton, Joseph P.

2007-01-01

173

Fragile X-associated disorders: a clinical overview  

Microsoft Academic Search

Fragile X Syndrome (FraX) is the most common inherited cause of learning disability worldwide. FraX is an X-linked neuro-developmental\\u000a disorder involving an unstable trinucleotide repeat expansion of cytosine guanine guanine (CGG). Individuals with the full\\u000a mutation of FraX have >200CGG repeats with premutation carriers having 55200CGG repeats. A wide spectrum of physical, behavioural,\\u000a cognitive, psychiatric and medical problems have been

Anne Gallagher; Brian Hallahan

174

49 CFR Appendix D to Part 230 - Civil Penalty Schedule  

Code of Federal Regulations, 2013 CFR

...otherwise test when FRA inspector or steam locomotive owner and/or operator...42Failure to have accurate boiler steam gauge where engine crew can conveniently read 2...gauge siphon of proper capacity on steam gauge supply pipe; failure...

2013-10-01

175

49 CFR Appendix D to Part 230 - Civil Penalty Schedule  

Code of Federal Regulations, 2012 CFR

...otherwise test when FRA inspector or steam locomotive owner and/or operator...42Failure to have accurate boiler steam gauge where engine crew can conveniently read 2...gauge siphon of proper capacity on steam gauge supply pipe; failure...

2012-10-01

176

49 CFR Appendix D to Part 230 - Civil Penalty Schedule  

Code of Federal Regulations, 2011 CFR

...otherwise test when FRA inspector or steam locomotive owner and/or operator...42Failure to have accurate boiler steam gauge where engine crew can conveniently read 2...gauge siphon of proper capacity on steam gauge supply pipe; failure...

2011-10-01

177

49 CFR 229.201 - Purpose and scope.  

Code of Federal Regulations, 2013 CFR

... Locomotive Crashworthiness Design Requirements 229.201...a shifted load on a freight car on an adjacent parallel track...new locomotive crashworthiness design standards; changes to FRA-approved locomotive crashworthiness design standards; and...

2013-10-01

178

49 CFR 229.201 - Purpose and scope.  

Code of Federal Regulations, 2010 CFR

... Locomotive Crashworthiness Design Requirements 229.201...a shifted load on a freight car on an adjacent parallel track...new locomotive crashworthiness design standards; changes to FRA-approved locomotive crashworthiness design standards; and...

2010-10-01

179

49 CFR 229.201 - Purpose and scope.  

Code of Federal Regulations, 2012 CFR

... Locomotive Crashworthiness Design Requirements 229.201...a shifted load on a freight car on an adjacent parallel track...new locomotive crashworthiness design standards; changes to FRA-approved locomotive crashworthiness design standards; and...

2012-10-01

180

49 CFR 229.201 - Purpose and scope.  

Code of Federal Regulations, 2011 CFR

... Locomotive Crashworthiness Design Requirements 229.201...a shifted load on a freight car on an adjacent parallel track...new locomotive crashworthiness design standards; changes to FRA-approved locomotive crashworthiness design standards; and...

2011-10-01

181

77 FR 23802 - Notice of Availability of a Final Environmental Impact Report/Environmental Impact Statement, a...  

Federal Register 2010, 2011, 2012, 2013

...CEQA) and CEQA Guidelines...USACE) and the Bureau...Agencies for the preparation of the EIS...Final EIS and Final Section...FRA's Web site: http...FOR FURTHER INFORMATION CONTACT...Environment and Systems Planning...

2012-04-20

182

53164 Federal Register / Vol. 77, No. 170 / Friday, August 31, 2012 / Proposed Rules Federal Communications Commission.  

E-print Network

Railroad Workplace Safety; Adjacent- Track On-Track Safety for Roadway Workers AGENCY: Federal Railroad, 2011, FRA published a final rule concerning adjacent-track on- track safety for roadway workers. See into the National Shellfish Sanitation Program. DAT

183

49 CFR 240.407 - Request for a hearing.  

Code of Federal Regulations, 2010 CFR

...of a hearing request complying with paragraph (d) of this section, FRA shall arrange for the appointment of a presiding officer who shall schedule the hearing for the earliest practicable date. [60 FR 53137, Oct. 12, 1995, as...

2010-10-01

184

49 CFR 240.407 - Request for a hearing.  

Code of Federal Regulations, 2011 CFR

...of a hearing request complying with paragraph (d) of this section, FRA shall arrange for the appointment of a presiding officer who shall schedule the hearing for the earliest practicable date. [60 FR 53137, Oct. 12, 1995, as...

2011-10-01

185

75 FR 74132 - Notice of Intent To Grant Buy America Waiver to Northern New England Passenger Rail Authority To...  

Federal Register 2010, 2011, 2012, 2013

...Administration Notice of Intent To Grant Buy America Waiver to Northern New England Passenger...DOT). ACTION: Notice of intent to grant Buy America waiver...Authority's (NNEPRA) waiver request from FRA's Buy America requirement, 49 U.S.C....

2010-11-30

186

78 FR 57449 - Notice Rescinding a Notice of Intent To Prepare a Programmatic Environmental Impact Statement...  

Federal Register 2010, 2011, 2012, 2013

...for the California-Nevada Interstate Maglev Project in cooperation with the project...late 1990s, FRA was implementing the Maglev Deployment Program (Program) created...was to demonstrate the feasibility of maglev technology. In addition to a number...

2013-09-18

187

78 FR 12824 - Notice of Application for Approval of Discontinuance or Modification of a Railroad Signal System...  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF TRANSPORTATION Federal Railroad Administration [Docket Number FRA-2002-14116...of Discontinuance or Modification of a Railroad Signal System or Relief From Requirements...January 21, 2013, the Grand Trunk Western Railroad Company (GTW), which operates...

2013-02-25

188

77 FR 2774 - Notice of Application for Approval of Discontinuance or Modification of a Railroad Signal System  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF TRANSPORTATION Federal Railroad Administration [Docket Number FRA-2003-15754...of Discontinuance or Modification of a Railroad Signal System In accordance with Part...Reading, Blue Mountain and Northern Railroad (RBMN) has petitioned the Federal...

2012-01-19

189

75 FR 34200 - Notice of Application for Approval of Discontinuance or Modification of a Railroad Signal System  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF TRANSPORTATION Federal Railroad Administration [Docket Number: FRA-2010-0083...of Discontinuance or Modification of a Railroad Signal System Pursuant to Title 49 Code...S.C. 20502(a), the following railroad has petitioned the Federal Railroad...

2010-06-16

190

78 FR 77787 - Notice of Joint Application for Approval of Discontinuance or Modification of a Railroad Signal...  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF TRANSPORTATION Federal Railroad Administration [Docket Number FRA-2013-0136...of Discontinuance or Modification of a Railroad Signal System In accordance with Part...Northeast Illinois Regional Commuter Railroad Corporation (NIRCRC), and CSX...

2013-12-24

191

78 FR 25344 - Notice of Application for Approval of Discontinuance or Modification of a Railroad Signal System  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF TRANSPORTATION Federal Railroad Administration [Docket Number FRA-2013-0037...of Discontinuance or Modification of a Railroad Signal System In accordance with Part...the Western New York & Pennsylvania Railroad, LLC (WNYP) has petitioned the...

2013-04-30

192

78 FR 71709 - Notice of Application for Approval of Discontinuance or Modification of a Railroad Signal System  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF TRANSPORTATION Federal Railroad Administration [Docket Number FRA-2013-0114...of Discontinuance or Modification of a Railroad Signal System In accordance with part...Southern Corporation (NS) and Bay Coast Railroad (BCR) jointly petitioned the...

2013-11-29

193

75 FR 179 - Notice of Petition for Waiver of Compliance and Scheduling of Public Hearing Association of...  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF TRANSPORTATION Federal Railroad Administration [Docket Number FRA-2009-0111...Public Hearing Association of American Railroads In accordance with part 211 of Title...notice that the Association of American Railroads (AAR) has petitioned the Federal...

2010-01-04

194

76 FR 4276 - Hazardous Materials: Improving the Safety of Railroad Transportation of Hazardous Materials  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF TRANSPORTATION Federal Railroad Administration 49 CFR Part 174 [Docket...Hazardous Materials: Improving the Safety of Railroad Transportation of Hazardous Materials AGENCY: Federal Railroad Administration (FRA), Department...

2011-01-25

195

76 FR 26682 - Study on Protection of Certain Railroad Risk Reduction Data From Discovery or Use in Litigation  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF TRANSPORTATION Federal Railroad Administration 49 CFR Chapter II...Study on Protection of Certain Railroad Risk Reduction Data From Discovery or Use in Litigation AGENCY: Federal Railroad Administration (FRA),...

2011-05-09

196

78 FR 77785 - Notice of Application for Approval of Discontinuance or Modification of a Railroad Signal System  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF TRANSPORTATION Federal Railroad Administration [Docket Number FRA-2013-0125...of Discontinuance or Modification of a Railroad Signal System In accordance with Part...dated September 3, 2013, Union Pacific Railroad (UP) and BNSF Railway (BNSF)...

2013-12-24

197

75 FR 76069 - Notice of Application for Approval of Discontinuance or Modification of a Railroad Signal System  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF TRANSPORTATION Federal Railroad Administration Docket Number FRA-2010-0154...of Discontinuance or Modification of a Railroad Signal System Pursuant to Title 49 Code...S.C. 20502(a), the following railroad has petitioned the Federal Railroad...

2010-12-07

198

78 FR 48224 - Lac-Mgantic Railroad Accident Discussion and DOT Safety Recommendations  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF TRANSPORTATION Federal Railroad Administration [Safety Advisory 2013-06...13-13] Lac-M[eacute]gantic Railroad Accident Discussion and DOT Safety Recommendations AGENCY: Federal Railroad Administration (FRA) and...

2013-08-07

199

78 FR 77787 - Notice of Application for Approval of Discontinuance or Modification of a Railroad Signal System  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF TRANSPORTATION Federal Railroad Administration [Docket Number FRA-2013-0130...of Discontinuance or Modification of a Railroad Signal System In accordance with Part...dated November 1, 2013, Union Pacific Railroad (UP) petitioned the Federal...

2013-12-24

200

75 FR 34200 - Notice of Application for Approval of Discontinuance or Modification of a Railroad Signal System  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF TRANSPORTATION Federal Railroad Administration [Docket Number FRA-2010-0084...of Discontinuance or Modification of a Railroad Signal System Pursuant to Title 49 Code...S.C. 20502(a), the following railroad has petitioned the Federal Railroad...

2010-06-16

201

75 FR 71488 - Notice of Application for Approval of Discontinuance or Modification of a Railroad Signal System  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF TRANSPORTATION Federal Railroad Administration [Docket Number FRA-2010-0160...of Discontinuance or Modification of a Railroad Signal System Pursuant to Title 49 Code...S.C. 20502(a), the following railroad has petitioned the Federal Railroad...

2010-11-23

202

75 FR 70771 - Notice of Application for Approval of Discontinuance or Modification of a Railroad Signal System  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF TRANSPORTATION Federal Railroad Administration [Docket Number FRA-2010-0157...of Discontinuance or Modification of a Railroad Signal System Pursuant to Title 49 Code...S.C. 20502(a), the following railroad has petitioned the Federal Railroad...

2010-11-18

203

76 FR 10086 - Notice of Application for Approval of Discontinuance or Modification of a Railroad Signal System  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF TRANSPORTATION Federal Railroad Administration [Docket Number FRA-2011-0008...of Discontinuance or Modification of a Railroad Signal System Pursuant to Title 49 Code...S.C. 20502(a), the following railroad has petitioned the Federal Railroad...

2011-02-23

204

75 FR 16552 - High-Speed Intercity Passenger Rail (HSIPR) Program  

Federal Register 2010, 2011, 2012, 2013

...OF TRANSPORTATION Federal Railroad Administration High-Speed...Program AGENCY: Federal Railroad Administration (FRA), Department...any necessary collision/derailment hazard analysis. The products...typically show: (i) Existing railroad right-of-way limits...

2010-04-01

205

78 FR 59086 - Proposed Agency Information Collection Activities; Comment Request  

Federal Register 2010, 2011, 2012, 2013

...No. 28, which requires railroads operating on the general...rail transportation and railroad equipment that is used on it against derailment situations similar to that...used by FRA to ensure that railroads and their employees...

2013-09-25

206

77 FR 19412 - Petition for Waiver of Compliance  

Federal Register 2010, 2011, 2012, 2013

...OF TRANSPORTATION Federal Railroad Administration [Docket Number...hereby given that the Federal Railroad Administration (FRA) has...is the former Rock Island Railroad main track and currently designated...experienced no line-haul derailments between Elk City and...

2012-03-30

207

78 FR 76709 - Proposed Agency Information Collection Activities; Comment Request  

Federal Register 2010, 2011, 2012, 2013

...No. 28, which requires railroads operating on the general...rail transportation and railroad equipment that is used on it against derailment situations similar to that...used by FRA to ensure that railroads and their employees...

2013-12-18

208

78 FR 51078 - Reporting Requirements for Positive Train Control Expenses and Investments  

Federal Register 2010, 2011, 2012, 2013

...operating statistics for each railroad. Currently, PTC expenditures...designates three classes of freight railroads based upon their operating...collisions, over-speed derailments, incursions into established...3\\ The Federal Railroad Administration (FRA)...

2013-08-20

209

78 FR 5767 - Positive Train Control Systems (RRR)  

Federal Register 2010, 2011, 2012, 2013

...standards for new construction of railroad tank cars designed to transport PIH...threshold, taking into account both derailment rates and the severity of derailments...continuous miles. FRA indicated that a railroad may seek relief under the...

2013-01-28

210

76 FR 63582 - Reporting Requirements for Positive Train Control Expenses and Investments  

Federal Register 2010, 2011, 2012, 2013

...operating statistics for each railroad. These reports ``shall...designates 3 classes of freight railroads based upon their operating...collisions, over-speed derailments, incursions into established...3\\ The Federal Railroad Administration (FRA)...

2011-10-13

211

78 FR 13747 - Railroad Safety: Advisory Notice Related to Railroad Accidents in Vicinity of Underground Pipelines  

Federal Register 2010, 2011, 2012, 2013

...Pipelines AGENCY: Federal Railroad Administration (FRA...Advisory Notice to inform railroads of the circumstances...the June 19, 2009, derailment of eastbound Canadian...IL, and to remind railroads of the need to...

2013-02-28

212

49 CFR Appendix G to Part 222 - Excess Risk Estimates for Public Highway-Rail Grade Crossings  

Code of Federal Regulations, 2011 CFR

... To be determined. Flashers with gates To be determined. Note One: The warning type column reflects primary warning device types. FRA is aware that a variety of arrangements are in place at individual crossings. Note Two:...

2011-10-01

213

49 CFR Appendix G to Part 222 - Excess Risk Estimates for Public Highway-Rail Grade Crossings  

Code of Federal Regulations, 2012 CFR

... To be determined. Flashers with gates To be determined. Note One: The warning type column reflects primary warning device types. FRA is aware that a variety of arrangements are in place at individual crossings. Note Two:...

2012-10-01

214

49 CFR Appendix G to Part 222 - Excess Risk Estimates for Public Highway-Rail Grade Crossings  

Code of Federal Regulations, 2013 CFR

... To be determined. Flashers with gates To be determined. Note One: The warning type column reflects primary warning device types. FRA is aware that a variety of arrangements are in place at individual crossings. Note Two:...

2013-10-01

215

www.ext.vt.edu Produced by Communications and Marketing, College of Agriculture and Life Sciences,  

E-print Network

, weathered sandstone, and/or the best available material. 2. Loosely grade the topsoil or topsoil substitute deals with the FRA's third step; it describes how to establish groundcover vegetation while controlling

Liskiewicz, Maciej

216

49 CFR 213.333 - Automated vehicle-based inspection systems.  

Code of Federal Regulations, 2013 CFR

...systems. (a) A qualifying Track Geometry Measurement System (TGMS) shall be...which specify that (1) Track geometry measurements shall be taken no more...otherwise approved by FRA; (2) Track geometry measurements shall be taken and...

2013-10-01

217

49 CFR 236.1001 - Purpose and scope.  

Code of Federal Regulations, 2011 CFR

...S.C. 20157, this subpart, or an FRA order, including requirements to ensure that the development, functionality, architecture, installation, implementation, inspection, testing, operation, maintenance, repair, and modification of...

2011-10-01

218

49 CFR 222.39 - How is a quiet zone established?  

Code of Federal Regulations, 2010 CFR

...must also include five-year projected vehicle and rail traffic counts for each newly established grade crossing; (3) 60-day comment period. (i) The public authority application for FRA approval of the proposed quiet zone shall...

2010-10-01

219

49 CFR Appendix E to Part 240 - Recommended Procedures for Conducting Skill Performance Tests  

Code of Federal Regulations, 2012 CFR

...for Conducting Skill Performance Tests FRA requires...engineers be given a skill performance test prior to...individual railroad companies latitude to tailor...administration of skill performance testing that occurs...railroad that requires the evaluation of an...

2012-10-01

220

49 CFR Appendix E to Part 240 - Recommended Procedures for Conducting Skill Performance Tests  

Code of Federal Regulations, 2011 CFR

...for Conducting Skill Performance Tests FRA requires...engineers be given a skill performance test prior to...individual railroad companies latitude to tailor...administration of skill performance testing that occurs...railroad that requires the evaluation of an...

2011-10-01

221

49 CFR Appendix E to Part 240 - Recommended Procedures for Conducting Skill Performance Tests  

Code of Federal Regulations, 2013 CFR

...for Conducting Skill Performance Tests FRA requires...engineers be given a skill performance test prior to...individual railroad companies latitude to tailor...administration of skill performance testing that occurs...railroad that requires the evaluation of an...

2013-10-01

222

76 FR 42682 - China Biotech Life Sciences Trade Mission-Clarification and Amendment  

Federal Register 2010, 2011, 2012, 2013

...International Trade Administration China Biotech Life Sciences Trade Mission--Clarification...supplement to the Notice of the Biotech Life Science Trade Mission to China, 76 FR...a variety of U.S. biotechnology and life science firms and trade...

2011-07-19

223

A NOVEL GENE, NMES1, DOWNREGULATED IN HUMAN ESOPHAGEAL SQUAMOUS CELL CARCINOMA  

E-print Network

­12 These include overexpression of CDC25B, matrix metalloproteinases, Notch1, Fra-1, Neogenin, CASK, Id-1, etc. Epidemiologic studies revealed that, different from adenocarcino- mas that developed from Barrett's esophagus

Tian, Weidong

224

Department of Transportation Semiannual Regulatory Agenda  

Federal Register 2010, 2011, 2012, 2013

...safety inquiry about radio communications and train control, FRA committed...radios and/or some means of wireless communication for certain trains and roadway...pipelines that transport highly volatile...

1997-10-29

225

Department of Transportation Semiannual Regulatory Agenda  

Federal Register 2010, 2011, 2012, 2013

... 2491. RAILROAD COMMUNICATIONS Priority: Substantive...safety inquiry about radio communications and train control, FRA committed...radios and/or some means of wireless communication for certain trains and...

1998-04-27

226

78 FR 46680 - Petition for Waiver of Compliance  

Federal Register 2010, 2011, 2012, 2013

...Other Non- Passenger Trains and Equipment; End-of-Train Devices. FRA assigned...Appendix B. AAR's Braking Systems Committee recently...freight or passenger trains. Additionally, the...has operated in this dual service since...

2013-08-01

227

77 FR 35106 - Proposed Agency Information Collection Activities; Comment Request  

Federal Register 2010, 2011, 2012, 2013

...to submit their safety appliance arrangement drawings, prints, etc., to the FRA Office of Safety...Company Name, and signature block, specific drawings, reflectorization, engineering information such as test or modeling of...

2012-06-12

228

77 FR 51843 - Information Collection Requirements (ICRs) Forwarded to the Office of Management and Budget (OMB...  

Federal Register 2010, 2011, 2012, 2013

...to submit their safety appliance arrangement drawings, prints, etc., to the FRA Office of Safety...Company Name, and signature block, specific drawings, reflectorization, engineering information such as test or modeling of...

2012-08-27

229

78 FR 5161 - National Highway-Rail Crossing Inventory Reporting Requirements  

Federal Register 2010, 2011, 2012, 2013

...INFORMATION: FRA has received written comments from interested parties, including Applied Research Associates, Inc. and Orion's Angels, related to the use of information submitted by railroads to the Crossing Inventory about the highway-rail...

2013-01-24

230

Energistyrelsen, EFP j. nr. 33032-0061 Fjernvarmedrevne  

E-print Network

Energistyrelsen, EFP j. nr. 33032-0061 Fjernvarmedrevne adsorptionsvarmepumper med jordlager til · Energi Danmark NRGi. Projektet er gennemført med støtte fra Energistyrelsens EFP-06 med Journal nr. 33032

231

Influence of planting treatments on American chestnut (Castanea dentata)  

E-print Network

replaced www.epa.gov #12;4/25/2009 2 Historic surface mining reclamation practices Left "as is" Valleys and Reclamation Act of 1977 Compaction Erosion Heavy Liming Grass Planted The Forestry Reclamation Approach (FRA

Gray, Matthew

232

49 CFR 230.61 - Arch tubes, water bar tubes, circulators and thermic siphons.  

Code of Federal Regulations, 2010 CFR

...OF TRANSPORTATION STEAM LOCOMOTIVE INSPECTION...MAINTENANCE STANDARDS Boilers and Appurtenances Washing Boilers 230.61 Arch...MAWP specified on the boiler specification FRA...of this part.) Steam...

2010-10-01

233

49 CFR 238.307 - Periodic mechanical inspection of passenger cars and unpowered vehicles used in passenger trains.  

Code of Federal Regulations, 2011 CFR

...section. Any alternative interval must be based upon a documented...The periodic inspection intervals provided in this section...that provides a high level of confidence that the component(s...compliance with any alternative interval adopted. FRA's...

2011-10-01

234

49 CFR 238.307 - Periodic mechanical inspection of passenger cars and unpowered vehicles used in passenger trains.  

Code of Federal Regulations, 2010 CFR

...section. Any alternative interval must be based upon a documented...The periodic inspection intervals provided in this section...that provides a high level of confidence that the component(s...compliance with any alternative interval adopted. FRA's...

2010-10-01

235

49 CFR Appendix E to Part 240 - Recommended Procedures for Conducting Skill Performance Tests  

Code of Federal Regulations, 2010 CFR

...mountainous terrain, and various signal systems place increased emphasis on the...immediately results in a fairly complex system. FRA therefore recommends...Properly use the train braking systems? Comply with speed...

2010-10-01

236

78 FR 25344 - Petition for a Waiver of Compliance  

Federal Register 2010, 2011, 2012, 2013

...part 240, Qualification and Certification of Locomotive Engineers. FRA assigned the petition Docket...provides that only certified persons may operate a locomotive in any class of locomotive or train service, in order to operate...

2013-04-30

237

49 CFR 216.13 - Special notice for repairs-locomotive.  

Code of Federal Regulations, 2012 CFR

...false Special notice for repairs-locomotive. 216.13 Section 216.13 Transportation...EMERGENCY ORDER PROCEDURES: RAILROAD TRACK, LOCOMOTIVE AND EQUIPMENT Special Notice for Repairs...13 Special notice for repairslocomotive. (a) When an FRA Motive...

2012-10-01

238

77 FR 9297 - Petition for Waiver of Compliance  

Federal Register 2010, 2011, 2012, 2013

...regulations contained at 49 CFR Part 230, Steam Locomotive Inspection and Maintenance Standards. FRA...maintains six narrow gauge (36-inch) steam locomotives; four 1925 Baldwin 2-8-2 locomotives and two 1923 Alco 2-8- 2...

2012-02-16

239

49 CFR 216.13 - Special notice for repairs-locomotive.  

Code of Federal Regulations, 2013 CFR

...false Special notice for repairs-locomotive. 216.13 Section 216.13 Transportation...EMERGENCY ORDER PROCEDURES: RAILROAD TRACK, LOCOMOTIVE AND EQUIPMENT Special Notice for Repairs...13 Special notice for repairslocomotive. (a) When an FRA Motive...

2013-10-01

240

78 FR 22364 - Petition for Waiver of Compliance  

Federal Register 2010, 2011, 2012, 2013

...Safety Glazing Standards--Locomotives, Passenger Cars and Cabooses...Number FRA-2011-0069. Kloke Locomotive Works is constructing for Steam...built (2013) replica of a steam locomotive that was originally built in...

2013-04-15

241

49 CFR 216.13 - Special notice for repairs-locomotive.  

Code of Federal Regulations, 2010 CFR

...false Special notice for repairs-locomotive. 216.13 Section 216.13 Transportation...EMERGENCY ORDER PROCEDURES: RAILROAD TRACK, LOCOMOTIVE AND EQUIPMENT Special Notice for Repairs...13 Special notice for repairslocomotive. (a) When an FRA Motive...

2010-10-01

242

49 CFR 216.13 - Special notice for repairs-locomotive.  

Code of Federal Regulations, 2011 CFR

...false Special notice for repairs-locomotive. 216.13 Section 216.13 Transportation...EMERGENCY ORDER PROCEDURES: RAILROAD TRACK, LOCOMOTIVE AND EQUIPMENT Special Notice for Repairs...13 Special notice for repairslocomotive. (a) When an FRA Motive...

2011-10-01

243

78 FR 59754 - Notice of Application for Approval of Discontinuance or Modification of a Railroad Signal System  

Federal Register 2010, 2011, 2012, 2013

...Number FRA-2013-0095. Applicant: Grenada Railway, LLC, Ms. Rhonda Nicoloff, Managing Member, 1505 South Redwood Road, Salt Lake City, UT 84104. GRYR seeks approval of the proposed discontinuance and removal of the automatic block...

2013-09-27

244

49 CFR 236.1001 - Purpose and scope.  

Code of Federal Regulations, 2013 CFR

...S.C. 20157, this subpart, or an FRA order, including requirements to ensure that the development, functionality, architecture, installation, implementation, inspection, testing, operation, maintenance, repair, and modification of...

2013-10-01

245

77 FR 21620 - Notice of the Buy America Waiver Request for Vossloh 101-LV Concrete Ties  

Federal Register 2010, 2011, 2012, 2013

...notice to advise the public that the Burlington Northern Santa Fe Railway Co. (``BNSF'') has submitted to FRA through or...Statement in the Federal Register published on April 11, 2000 (65 FR 19477), or you may visit...

2012-04-10

246

75 FR 41281 - Bridge Safety Standards  

Federal Register 2010, 2011, 2012, 2013

...cars and locomotives. B. Guidelines On April 27, 1995, FRA issued...policy statement contained guidelines for the proper maintenance...Security Administration (TSA); and United Transportation...right-of- way). 6. The guidelines published in this...

2010-07-15

247

Arbeidskapasitet, fatigue og helserelatert livskvalitet for pasienter med Myalgisk Encefalopati eller Kronisk Utmattelses Syndrom fr og etter trening med Qigong : En randomisert kontrollert studie.  

E-print Network

??Forml: Hensikten med denne studien var underske arbeidskapasitet, fatigue(tretthet) og helserelatert livskvalitet hos en gruppe personer diagnostisert med CFS/ME sammenlignet med referanse materiale fra (more)

Dybwad, Marianne Holth

2007-01-01

248

76 FR 59482 - Petition for Waivers of Compliance  

Federal Register 2010, 2011, 2012, 2013

...OF TRANSPORTATION Federal Railroad Administration [Docket Number...hereby given that the Federal Railroad Administration (FRA) has...America's fifth largest railroad; with 20,600 route miles...network in Canada and the only transcontinental network in North...

2011-09-26

249

77 FR 48591 - State Rail Plan Guidance  

Federal Register 2010, 2011, 2012, 2013

...Docket No. FRA-2012-0066] State Rail Plan Guidance AGENCY: Federal Railroad...Request for Public Comment on Proposed State Rail Plan Guidance...submission, and acceptance of State rail plans. State rail plans are...

2012-08-14

250

78 FR 28940 - Environmental Impact Statement for the Atlanta to Charlotte Portion of the Southeast High Speed...  

Federal Register 2010, 2011, 2012, 2013

...to Charlotte Portion of the Southeast High Speed Rail Corridor AGENCY: Federal Rail Administration (FRA), DOT. ACTION: Notice of...Statement (Study) to evaluate potential passenger rail improvements between Atlanta, GA and...

2013-05-16

251

78 FR 57450 - State Rail Plan Guidance  

Federal Register 2010, 2011, 2012, 2013

...Docket No. FRA-2012-0066] State Rail Plan Guidance AGENCY: Federal Railroad...Notice of Availability of Final State Rail Plan Guidance...announce the availability of final State Rail Plan Guidance. The purpose of...

2013-09-18

252

78 FR 57450 - Notice Rescinding a Notice of Intent To Prepare an Environmental Impact Statement for the...  

Federal Register 2010, 2011, 2012, 2013

...Impact Statement for the Altamont Corridor Rail Project From Stockton to San Jose, California...statement (EIS) for the Altamont Corridor Rail Project from Stockton to San Jose, California...project sponsor, the California High Speed Rail Authority (Authority). FRA...

2013-09-18

253

77 FR 38388 - Notice of Decision to Grant Buy America Waiver to Washington Department of Transportation to...  

Federal Register 2010, 2011, 2012, 2013

...Transportation to Purchase Vossloh 101-LV Concrete Rail Ties AGENCY: Federal Railroad Administration...waiver request from the FRA Passenger Rail Investment and Improvement Act (PRIIA...concrete ties in the Pacific Northwest Rail Corridor high-speed intercity...

2012-06-27

254

75 FR 17203 - National Rail Plan  

Federal Register 2010, 2011, 2012, 2013

...Docket No. FRA-2010-0020] National Rail Plan AGENCY: Federal Railroad Administration...development of the long-range National Rail Plan (NRP) through an open docket. In...INFORMATION: Background: The Passenger Rail Investment and Improvement Act of...

2010-04-05

255

77 FR 74546 - Proposed Agency Information Collection Activities; Comment Request  

Federal Register 2010, 2011, 2012, 2013

...requiring that locomotive horns be sounded when trains...blowing locomotive horns exists for corridors in which horns are silenced. FRA...Affairs, Office of Management and Budget, 725 Seventeenth...of having its full effect if OMB receives...

2012-12-14

256

75 FR 82138 - Petition for Waiver of Compliance  

Federal Register 2010, 2011, 2012, 2013

...arguments in favor of relief. City of Vancouver, Washington [Waiver Petition...FRA-2010-0170] The City of Vancouver, WA (City), seeks a permanent...a Home Occupation Permit under Vancouver Municipal Code Chapter...

2010-12-29

257

77 FR 55265 - Environmental Impact Statement for the Northeast Corridor Between Washington, DC, New York, NY...  

Federal Register 2010, 2011, 2012, 2013

...Corridor Between Washington, DC, New York, NY, and Boston, MA AGENCY: Federal Railroad Administration (FRA), U.S. Department...improvements between Washington, DC, New York City, and Boston, MA was published in the Federal Register on June 22, 2012....

2012-09-07

258

49 CFR 228.201 - Electronic recordkeeping; general.  

Code of Federal Regulations, 2011 CFR

...security program adequate to ensure the integrity of the system, including the prevention of unauthorized access to the program logic or individual records. (6) FRA's Associate Administrator for Railroad Safety/Chief Safety Officer may prohibit or...

2011-10-01

259

49 CFR 228.201 - Electronic recordkeeping; general.  

Code of Federal Regulations, 2012 CFR

...security program adequate to ensure the integrity of the system, including the prevention of unauthorized access to the program logic or individual records. (6) FRA's Associate Administrator for Railroad Safety/Chief Safety Officer may prohibit or...

2012-10-01

260

49 CFR 228.201 - Electronic recordkeeping; general.  

Code of Federal Regulations, 2013 CFR

...security program adequate to ensure the integrity of the system, including the prevention of unauthorized access to the program logic or individual records. (6) FRA's Associate Administrator for Railroad Safety/Chief Safety Officer may prohibit or...

2013-10-01

261

49 CFR 229.29 - Biennial tests.  

Code of Federal Regulations, 2010 CFR

...all valves, valve portions, MU locomotive brake cylinders and electric-pneumatic master controllers in the air brake system...date and place of the cleaning, repairing, and testing shall be recorded on Form FRA F...

2010-10-01

262

49 CFR 229.29 - Biennial tests.  

Code of Federal Regulations, 2011 CFR

...all valves, valve portions, MU locomotive brake cylinders and electric-pneumatic master controllers in the air brake system...date and place of the cleaning, repairing, and testing shall be recorded on Form FRA F...

2011-10-01

263

Acute Toxicological Responses of Fischer Rats to Naturally Occurring Asbestos from theUnited States and Canada  

EPA Science Inventory

This study was designed to provide understanding of the toxicity of naturally occurring asbestos (NOA) including Libby amphibole (LA), Sumas Mountain chrysotile (SM), EI Dorado Hills tremolite (ED) and Ontario actinolite/ferroactinolite cleavage fragments (ON). Ratrespirable fra...

264

78 FR 47822 - Notice of Application for Approval of Discontinuance or Modification of a Railroad Signal System  

Federal Register 2010, 2011, 2012, 2013

...petition Docket Number FRA-2013-0076. Applicant: Port of Los Angeles, Mr. Ron Groves, PE, Senior Civil Engineer, Engineering Division, 425 South Palos Verdes Street, San Pedro, CA 90731. POLA seeks approval of the proposed...

2013-08-06

265

49 CFR 230.5 - Preemptive effect.  

Code of Federal Regulations, 2010 CFR

...jurisdiction. Therefore, in issuing this part, it is FRA's intent that State laws or regulations applicable to those rail operations to which this part does not apply (i.e., insular tourist operations) not be...

2010-10-01

266

49 CFR 230.5 - Preemptive effect.  

Code of Federal Regulations, 2011 CFR

...jurisdiction. Therefore, in issuing this part, it is FRA's intent that State laws or regulations applicable to those rail operations to which this part does not apply (i.e., insular tourist operations) not be...

2011-10-01

267

Fragile (X)(q27) sites in a pedigree with female carriers showing mild to severe mental retardation.  

PubMed Central

A pedigree showing the fragile site at Xq27 in a severely retarded female and in other less retarded carriers is described. Two of the four moderately retarded males with the fra(X)(q27) show macro-orchidism, and a variety of other features usually used to support the effects of the fra(X)(q27) are also inconsistent. A second fragile site at (10)(q23) is also present and in the two oldest females its frequency is not decreased, whereas the fra(x)(q27) is not detectable in these females although probably present. It is concluded that pedigrees showing mentally retarded females and probable X linkage should be included in studies of the fra(X)(q27). Images PMID:7069746

Webb, G C; Halliday, J L; Pitt, D B; Judge, C G; Leversha, M

1982-01-01

268

76 FR 1209 - Establishment of an Emergency Relief Docket for Calendar Year 2011  

Federal Register 2010, 2011, 2012, 2013

...Establishment of an Emergency Relief Docket for Calendar Year 2011 AGENCY: Federal Railroad Administration...FRA's emergency relief docket (ERD) for calendar year 2011. The designated ERD for calendar year 2011 is docket number...

2011-01-07

269

77 FR 5293 - Establishment of an Emergency Relief Docket for Calendar Year 2012  

Federal Register 2010, 2011, 2012, 2013

...Establishment of an Emergency Relief Docket for Calendar Year 2012 AGENCY: Federal Railroad Administration...FRA's emergency relief docket (ERD) for calendar year 2012. The designated ERD for calendar year 2012 is docket number...

2012-02-02

270

78 FR 3964 - Establishment of an Emergency Relief Docket for Calendar Year 2013  

Federal Register 2010, 2011, 2012, 2013

...Establishment of an Emergency Relief Docket for Calendar Year 2013 AGENCY: Federal Railroad Administration...FRA's emergency relief docket (ERD) for calendar year 2013. The designated ERD for calendar year 2013 is docket number...

2013-01-17

271

75 FR 3782 - Establishment of an Emergency Relief Docket for Calendar Year 2010  

Federal Register 2010, 2011, 2012, 2013

...Establishment of an Emergency Relief Docket for Calendar Year 2010 AGENCY: Federal Railroad Administration...FRA's emergency relief docket (ERD) for calendar year 2010. The designated ERD for calendar year 2010 is docket number...

2010-01-22

272

75 FR 60860 - Petition for Waiver of Compliance  

Federal Register 2010, 2011, 2012, 2013

...arguments in favor of relief. Port Manatee Railroad [Waiver Petition Docket Number FRA-2010-0091] The Port Manatee Railroad (PMRR) seeks a waiver of...terminal- switching railway operated on Manatee County Authority property at Port...

2010-10-01

273

Autism spectrum disorder in fragile X syndrome: Communication, social interaction, and specific behaviors  

Microsoft Academic Search

The present study extends our previous work on social behavior impairment in young males with fragile X syndrome (FraX). Specifically, we evalu- ated whether the autistic phenomenon in FraX is expressed as a range of behavioral impairments as in idiopathic autism (Aut). We also examined whether there are behaviors, identified as items of the Autism Diagnostic Interview-Revised (ADI- R), that

Walter E. Kaufmann; Ranon Cortell; Alice S. M. Kau; Irena Bukelis; Elaine Tierney; Robert M. Gray; Christiane Cox; George T. Capone; Pia Stanard

2004-01-01

274

Virulent non-capsulate Yersinia pestis variants constructed by insertion mutagenesis  

Microsoft Academic Search

Summary. Insertion mutagenesis with the help of the plasmid pFS23 was used to generate Yersinia pestis fra mutants. The results of pFra- strain production under non-selective conditions suggested that such Y. pestis variants may be generated in natural plague foci at high frequency and may participate in supporting the epizootic process. Present data suggest that the reduction of virulence in

I. G. Drozdov; A. P. ANISIMOVP; S. V. Samoilova; I. N. Yezhov; S. A. Yeremin; A. V. Karlyshev; V. M. Krasilnikova; V. I. Kravchenko

1995-01-01

275

Focal retrograde amnesia and the episodicsemantic distinction  

Microsoft Academic Search

This article reports a review of focal retrograde amnesia (FRA), or the phenomenon of organically based severe memory loss\\u000a restricted to retrograde, or pretraumatic, memory. Cases of FRA are classified according to the type of memory loss: episodic,\\u000a semantic, or both. A few different clusters of the disorder were identified. Lesions to either the anterior temporal lobes\\u000a or the posterior\\/visual

Mark A. Wheeler; Corey T. Mcmillan

2001-01-01

276

Intorno ad un teorema di Hodge sulla teoria della base per le curve di una superficie algebrica  

Microsoft Academic Search

SuntoSi dimostra, con procedimento algebrico-geometrico assai semplice, un teorema diHodge sulla teoria della base per le curve tracciate sopra una superficie algebrica; da questo si traggono poi varie conseguenze,\\u000a concernenti i gradi virtuali delle curve di una superficie algebrica o delle corrispondenze fra due curve algebriche, il principio\\u000a di degenerazione diEnriques, e la teoria diSeveri delle corrispondenze fra due superficie

Beniamino Segre

1937-01-01

277

Expression of immediate early genes in the hippocampal formation of the black-capped chickadee ( Poecile atricapillus) during a food-hoarding task  

Microsoft Academic Search

Black-capped chickadees store food in many different locations in their home range and are able to accurately remember these locations. We measured the number of cells immunopositive for three different Immediate Early Gene products (Fra-1, c-Fos and ZENK) to map neuronal activity in the chickadee Hippocampal Formation (HF) during food storing and retrieval. Fra-1-like immunoreactivity is downregulated in the dorsal

Tom V. Smulders; Timothy J. Devoogd

2000-01-01

278

Economic Growth and Inequality: Drawing the  

E-print Network

-Eisenhower Professor of Economics Johns Hopkins University #12;This Session High-level, helicopter view of one piece Swe Swi Tur US Yem Zim Aus Bul Cam Cro SV Est Fin Fra Ger Gre Hon Ice Kaz Kor Lit Nam Nor Por Rom Slo Swe Swi Tur US Yem Zim Aus Bul Cam Cro SV Est Fin Fra Ger Gre Hon Ice Kaz Kor Lit Nam Nor Por Rom Slo

von der Heydt, Rüdiger

279

Cardiomyopathy in murine models of systemic sclerosis.  

PubMed

Objectives. Cardiomyopathy has emerged as a leading cause of death in systemic sclerosis (SSc). However, the pathogenesis of SSc-related cardiomyopathy is poorly understood and new therapies as well as platforms for testing are needed. Here, we aimed to characterize the histopathological features of cardiomyopathy in SSc patients and in common mouse models of SSc. Methods. The histopathological features in myocardial tissues of five patients with SSc and five controls matched for sex, age and cardiovascular risk factors were evaluated and compared to those of three common mouse models of SSc with systemic manifestations: Fra-2 transgenic (Fra-2 tg) mice, mice with sclerodermatous chronic Graft versus Host disease (cGvHD) and tight skin 1 (Tsk-1) mice. Results: Myocardial tissues of SSc patients without clinically manifest cardiac involvement showed endothelial cell apoptosis with reduced capillary density, perivascular inflammation, myofibroblast differentiation and accumulation of collagen. The cGvHD and Tsk-1 models displayed only selected features of SSc-related cardiomyopathy. However, myocardial tissue of Fra-2 tg mice mimicked all features of SSc-related cardiomyopathy and also demonstrated comparable vascular, inflammatory and fibrotic manifestations. Of note, the expression of Fra-2 was also increased in the myocardium of SSc patients. Conclusions. We demonstrate that all typical manifestations of SSc-related cardiomyopathy are mimicked by Fra-2 tg mice. Moreover, the overexpression of Fra-2 in the myocardium of SSc patients may suggest similar underlying pathomechanisms. Thus, Fra-2 tg mice might be a suitable preclinical model to study the mechanisms and therapeutic approaches of myocardial involvement in SSc. \\ 2014 American College of Rheumatology. PMID:25371068

Venalis, Paulius; Kumnovics, Gbor; Schulze-Koops, Hendrik; Distler, Alfiya; Dees, Clara; Zerr, Pawel; Palumbo-Zerr, Katrin; Czirjk, Lszl; Mackevic, Zygmunt; Lundberg, Ingrid E; Distler, Oliver; Schett, Georg; Distler, Jrg H W

2014-11-01

280

Optimum design of a hybrid erbium-doped fiber amplifier/fiber Raman amplifier using particle swarm optimization.  

PubMed

We propose and optimize a hybrid erbium-doped fiber amplifier/fiber Raman amplifier (EDFA/FRA). A large number of parameters of a wide-band hybrid amplifier consisting of an erbium-doped fiber amplifier (EDFA) and a fiber Raman amplifier (FRA) have been optimized using an effective and fast global optimization method called particle swarm optimization. Two types of hybrid EDFA/FRA with six- and 10-pumped FRAs have been optimized. A large number of variables affect the hybrid EDFA/FRA performance, thus we need a global optimization method to be able to deal with these variables. Particle swarm optimization helps us to find optimum parameters of a hybrid EDFA/FRA and reduce the gain spectrum variations to 2.91 and 2.03 dB for the six and 10 pumped FRAs, respectively. The optimum design supports the amplification of 60 signal channels in the wavelength range of 1529.2-1627.1 nm for a wavelength-division multiplexing system. PMID:19209214

Mowla, Alireza; Granpayeh, Nosrat

2009-02-10

281

Effect of serotonin on the expression of antigens and DNA levels in Yersinia pestis cells with different plasmid content  

NASA Astrophysics Data System (ADS)

Using flow cytometry (FCM) the influence of exogenous serotonin on culture growth, DNA content and fluorescence intensity of cells binding FITC-labelled plague polyclonal immunoglobulins was studied in Yersinia pestis EV (pFra+, pCad+, pPst+), Yersinia pestis KM218 (pFra-, pCad-, pPst-), Yersinia pestis KM 216 (pFra-, pCad-, pPst+). The results have been obtained by FCM showed serotonin accelerated Yersinia pestis EV (pFra+, pCad+, pPst+), Yersinia pestis KM218 (pFra-, pCad-, pPst-) culture growth during cultivation in Hottinger broth pH 7.2 at 28C at concentration of 10-5 M. The presence of 10-5 M serotonin in nutrient broth could modulate DNA content in 37C growing population of plague microbe independently of their plasmid content. Serotonin have been an impact on the distribution pattern of the cells according to their phenotypical characteristics, which was reflected in the levels of population heterogeneity in the intensity of specific immunofluorescence determined by FMC.

Klueva, Svetlana N.; Korsukov, Vladimir N.; Schukovskaya, Tatyana N.; Kravtsov, Alexander L.

2004-08-01

282

Bilberry extracts induce gene expression through the electrophile response element.  

PubMed

A number of genes important for detoxification and antioxidant defense induced by mild stress generated by, for example, physical activity/exercise, caloric restriction, or alcohol may provide health benefits by causing the organism to mount such a defense response. More recently, induction of these defenses has also been attributed to phytochemicals or secondary metabolites from dietary plants. Many polyphenols, which constitute a large fraction of these phytochemicals, increase cellular levels of antioxidants, such as glutathione and other components of the detoxification systems, via the transactivation of genes containing electrophile response elements (EpREs) within their promoters. One such gene, gamma-glutamylcysteine synthetase, has previously been shown to be positively regulated by quercetin, a flavonoid found in high concentrations in onions, apples, and bilberries through EpRE transactivation. As a further step, we have investigated whether bilberries and quercetin have the ability to induce transcription of Fos-related antigen 1 (Fra-1), which contains two EpREs in its promoter. Fra-1 is a member of the activator protein 1 (AP-1) family of transcription factors and, due to the lack of transactivation domain Fra-1, can suppress activation of AP-1. We present results demonstrating that extracts from bilberries, and the flavonoid quercetin, abundant in bilberries, induce the fra-1 promoter and the cellular content of Fra-1 mRNA. We further provide evidence that this induction is mediated through EpREs. PMID:16800777

Myhrstad, Mari Charlotte Wik; Carlsen, Harald; Dahl, Linn Ingrid; Ebihara, Kanae; Glemmestad, Line; Haffner, Karin; Moskaug, Jan ivind; Blomhoff, Rune

2006-01-01

283

Discrimination of the spectral structures of sound signals on the background of interference.  

PubMed

Presentation of test signals consisting of sounds with rippled spectra allowed measurements of the frequency-resolving ability (FRA) of hearing to be performed in humans without using frequency-dependent masking techniques. This allowed studies of changes in FRA in the presence of noise interference. In conditions of diotic presentation (to both ears in parallel) of the test signal and noise, FRA decreased significantly if the interference frequency was lower or equal to the test signal frequency. The relationship between this effect and the sound intensity and noise:signal ratio varied for low-frequency noise and for noise at the same frequency as the test signal, which indicates that these two types of interference have different mechanisms. However, in both cases, noise of sufficient intensity led to a complete inability to discriminate the fine spectral structure of the test signal. In dichotic presentation (test signal to one ear, noise to the other), noise had virtually no effect on FRA over a wide range of test signal and noise frequencies and noise:signal ratios. Thus, there was essentially complete dichotic release of FRA from the effects noise, which has potential to be used in constructing prosthetic hearing devices. PMID:18607753

Supin, A Ya

2008-06-01

284

Flamingo, a seven-pass transmembrane cadherin, cooperates with Netrin/Frazzled in Drosophila midline guidance.  

PubMed

During central nervous system development, several guidance cues and receptors, as well as cell adhesion molecules, are required for guiding axons across the midline and along the anterior-posterior axis. In Drosophila, commissural axons sense the midline attractants Netrin A and B (Net) through Frazzled (Fra) receptors. Despite their importance, lack of Net or fra affects only some commissures, suggesting that additional molecules can fulfill this function. Recently, planar cell polarity (PCP) proteins have been implicated in midline axon guidance in both vertebrate and invertebrate systems. Here, we report that the atypical cadherin and PCP molecule Flamingo/Starry night (Fmi/Stan) acts jointly with Net/Fra signaling during midline development. Additional removal of fmi strongly increases the guidance defects in Net/fra mutants. Rescue and domain deletion experiments suggest that Fmi signaling facilitates commissural pathfinding potentially by mediating axonal fasciculation in a partly homophilic manner. Altogether, our results indicate that contact-mediated cell adhesion via Fmi acts in addition to the Net/Fra guidance system during axon pathfinding across the midline, underlining the importance of PCP molecules during vertebrates and invertebrates midline development. PMID:25440577

Organisti, Cristina; Hein, Irina; Grunwald Kadow, Ilona C; Suzuki, Takashi

2015-01-01

285

Variation at the fragile X locus does not influence susceptibility to bipolar disorder  

SciTech Connect

Over the last 20 years several pedigrees have been reported which are suggestive of linkage between susceptibility to bipolar disorder and markers on chromosome Xq28. Other workers have failed to replicate these reports and the methodology of the positive reports has been criticized. Recently there have been several reports of an association between fragile X (FRA(X)) and affective disorder within families and in unrelated individuals compared with controls. Such reports could be consistent with the Xq28 marker reports because FRA(X) maps to Xq27.3. We report a study at the FRA(X) CGG repeat locus in 79 unrelated Caucasian bipolar probands without fragile X syndrome and 77 unrelated controls. We found no evidence that variation at this locus confers susceptibility to bipolar disorder. 28 refs., 1 fig.

Craddock, N.; Daniels, J.; McGuffin, P. [Univ. of Wales College of Medicine, Cardiff (United Kingdom)] [and others

1994-06-15

286

Safety recommendations and responses availability. [Tank car safety  

SciTech Connect

Documents available from the US National Transportation Safety Board (NTSB) include a response by the US Federal Railroad Administration (FRA) to NTSB's report, ''The Accident Performance of Tank Car Safeguards''. FRA has agreed to extend the requirements for top-and-bottom shelf couplers to all tank cars used to transport hazardous materials, and those for head shields and thermal protection to new and rebuilt specification DOT 105 tank cars; to examine the protection afforded to ''nonpressure'' tank cars used to transport specialty products and Class A poisons; to study the ways in which to minimize the damage to the top fittings and bottom outlet valves following train accidents and incorporate these with new car construction; to collect data on tank car derailment behavior to identify breach mechanisms (FRA work in progress); and to conduct studies to evaluate the safe positions in freight trains for placarded hazardous materials rail cars.

Not Available

1980-08-28

287

Fructose-asparagine is a primary nutrient during growth of Salmonella in the inflamed intestine.  

PubMed

Salmonella enterica serovar Typhimurium (Salmonella) is one of the most significant food-borne pathogens affecting both humans and agriculture. We have determined that Salmonella encodes an uptake and utilization pathway specific for a novel nutrient, fructose-asparagine (F-Asn), which is essential for Salmonella fitness in the inflamed intestine (modeled using germ-free, streptomycin-treated, ex-germ-free with human microbiota, and IL10-/- mice). The locus encoding F-Asn utilization, fra, provides an advantage only if Salmonella can initiate inflammation and use tetrathionate as a terminal electron acceptor for anaerobic respiration (the fra phenotype is lost in Salmonella SPI1- SPI2- or ttrA mutants, respectively). The severe fitness defect of a Salmonella fra mutant suggests that F-Asn is the primary nutrient utilized by Salmonella in the inflamed intestine and that this system provides a valuable target for novel therapies. PMID:24967579

Ali, Mohamed M; Newsom, David L; Gonzlez, Juan F; Sabag-Daigle, Anice; Stahl, Christopher; Steidley, Brandi; Dubena, Judith; Dyszel, Jessica L; Smith, Jenee N; Dieye, Yakhya; Arsenescu, Razvan; Boyaka, Prosper N; Krakowka, Steven; Romeo, Tony; Behrman, Edward J; White, Peter; Ahmer, Brian M M

2014-06-01

288

Regulation of steatohepatitis and PPAR? signaling by distinct AP-1 dimers  

PubMed Central

Summary Non-alcoholic fatty liver disease (NAFLD) affects up to 30% of the adult population in Western societies, yet the underlying molecular pathways remain poorly understood. Here, we identify the dimeric Activator Protein 1 as a regulator of NAFLD. The Fos-related antigen 1 (Fra-1) and 2 (Fra-2) prevent dietary NAFLD by inhibiting pro-steatotic PPAR? signaling. Moreover, established NAFLD and the associated liver damage can be efficiently reversed by hepatocyte-specific Fra-1 expression. In contrast, c-Fos promotes PPAR? expression, while c-Jun exerts opposing, dimer-dependent functions. Interestingly, JunD was found to be essential for PPAR? signaling and NAFLD development. This unique antagonistic regulation of PPAR? by distinct AP-1 dimers occurs at the transcriptional level and establishes AP-1 as a link between obesity, hepatic lipid metabolism and NAFLD. PMID:24411941

Hasenfuss, Sebastian C.; Bakiri, Latifa; Thomsen, Martin K.; Williams, Evan G.; Auwerx, Johan; Wagner, Erwin F.

2014-01-01

289

Genetic and interval mapping of the bovine X chromosome for quantitative trait loci using microsatellite markers  

E-print Network

of deletions and translocations (GI. OvER and STEIN 1988). Active exploration of fragile sites began in the late 1970s when the fragile X (fra(X)) syndrome was recognized to be a common chromosomal abnormality in mental retardation (GIRAUD et a/. 1976, HARv...EY et al. 1977). It is associated with an unusual form of X-linked inheritance where both men and women can be carriers (SHAPIRO 1991). Over 30'/0 of female carriers of the fra(X) syndrome are clinically affected. The condition has been mapped to Xq27...

Yeh, Chen-Chen

2012-06-07

290

Nearly pure Apollo 12 KREEP - Soil sample 12023  

NASA Technical Reports Server (NTRS)

It is suggested that soil sample 12023, which was collected during the Apollo 12 mission from a 20 cm trench on the east rim of Sharp Crater, matured on a KREEP regolith surface, since its major element chemistry and FMR linewidth are indistinguishable from those of the Fra Mauro (Apollo 14) soils. Attention is given to the distribution of the sample's major mineral components. It is suggested that the origin of 12023 may either be ejecta from Fra Mauro material, or ray material from the Copernicus crater.

Morris, R. V.; Warner, J. L.; Mckay, D. S.; Brown, R. W.

1977-01-01

291

Stable and uniform multi-wavelength fiber laser based on hybrid Raman and Erbium-doped fiber gains.  

PubMed

A stable and uniform multi-wavelength fiber laser based on the hybrid gain of a dispersion compensating fiber (as the Raman gain medium) and an Erbium-doped fiber (EDF) is introduced. The gain competition effects in the fiber Raman amplification (FRA) and EDF amplification are analyzed and compared experimentally. The FRA gain mechanism can suppress the gain competition effectively and make the present multi-wavelength laser stable at room temperature. The hybrid gain medium can also increase the lasing bandwidth (as compared with a pure EDF laser) and the power conversion efficiency (as compared with a pure fiber Raman laser). PMID:19529453

Qin, Shan; Chen, Daru; Tang, Yongbo; He, Sailing

2006-10-30

292

Differential regulation of fos family genes in the ventrolateral and dorsomedial subdivisions of the rat suprachiasmatic nucleus.  

PubMed

Extensive studies have established that light regulates c-fos gene expression in the suprachiasmatic nucleus, the site of an endogenous circadian clock, but relatively little is known about the expression of genes structurally related to c-fos, including fra-1, fra-2 and fosB. We analysed the photic and temporal regulation of these genes at the messenger RNA and immunoreactive protein levels in rat suprachiasmatic nucleus, and we found different expression patterns after photic stimulation and depending on location in the ventrolateral or dorsomedial subdivisions. In the ventrolateral suprachiasmatic nucleus, c-fos, fra-2 and fosB expression was stimulated after a subjective-night (but not subjective-day) light pulse. Expression of the fra-2 gene was prolonged following photic stimulation, with elevated messenger RNA and protein levels that appeared unchanged for at least a few hours beyond the c-fos peak. Unlike c-fos and fra-2, the fosB gene appeared to be expressed constitutively in the ventrolateral suprachiasmatic nucleus throughout the circadian cycle; immunohistochemical analysis suggested that delta FosB was the protein product accounting for this constitutive expression, while FosB was induced by the subjective-night light pulse. In the dorsomedial suprachiasmatic nucleus, c-fos and fra-2 expression exhibited an endogenous circadian rhythm, with higher levels during the early subjective day, although the relative abundance was much lower than that measured after light pulses in the ventrolateral suprachiasmatic nucleus. Double-label immunohistochemistry suggested that some of the dorsomedial cells responsible for the circadian expression of c-Fos also synthesized arginine vasopressin. No evidence of suprachiasmatic nucleus fra-1 expression was found. In summary, fos family genes exhibit differences in their specific expression patterns in the suprachiasmatic nucleus, including their photic and circadian regulation in separate cell populations in the ventrolateral and dorsomedial subdivisions. The data, in combination with our previous results [Takeuchi J. et al. (1993) Neuron 11, 825-836], suggest that activator protein-1 binding sites on ventrolateral suprachiasmatic nucleus target genes are constitutively occupied by DeltaFosB/JunD complexes, and that c-Fos, Fra-2, FosB and JunB compete for binding after photic stimulation. The differential regulation of fos family genes in the ventrolateral and dorsomedial suprachiasmatic nucleus suggests that their circadian function(s) and downstream target(s) are likely to be cell specific. PMID:10869847

Schwartz, W J; Carpino, A; de la Iglesia, H O; Baler, R; Klein, D C; Nakabeppu, Y; Aronin, N

2000-01-01

293

49 CFR 225.41 - Suicide data.  

Code of Federal Regulations, 2012 CFR

... 2012-10-01 2012-10-01 false Suicide data. 225.41 Section 225.41 Transportation...CLASSIFICATION, AND INVESTIGATIONS 225.41 Suicide data. FRA does not include suicide data (as defined in 225.5) in its...

2012-10-01

294

49 CFR 225.41 - Suicide data.  

Code of Federal Regulations, 2013 CFR

... 2013-10-01 2013-10-01 false Suicide data. 225.41 Section 225.41 Transportation...CLASSIFICATION, AND INVESTIGATIONS 225.41 Suicide data. FRA does not include suicide data (as defined in 225.5) in its...

2013-10-01

295

O3, CO2 and chemical fractionation in ponderosa pine saplings  

EPA Science Inventory

Environmental factors can affect plant tissue quality which is important for quality of organic matter inputs into soil food webs and decomposition of soil organic matter. Thus the effects of increases in CO2 and O3 and their interactions were determined for various chemical fra...

296

College of Earth, Ocean, and Atmospheric Sciences Oregon State University  

E-print Network

for scientific research programs performed at sea. Responsibilities: Marine Instrumentation Engineer: Provides students. Graduate programs include a Master's degree in Marine Resource Management, and Master college for the Earth. This Faculty Research Assistant (FRA) serves as a member of the Marine Technician

297

DPSK Modulated (Tbit/s) Transmission Incorporating Dispersion-compensated Hybrid Amplifier  

NASA Astrophysics Data System (ADS)

The simulative implementation of differential phase shift keying (DPSK) modulated data transmission incorporating single-pump highly efficient dispersion compensated Raman/EDFA hybrid amplifier is demonstrated. The simulative results are discussed to compare two different types of configurations of dispersion compensated 16-channel wavelength division multiplexing (WDM) system to achieve transmission of Tbit/s data. In pre-compensation technique, dispersion compensated fiber (DCF) is used prior to fiber Raman amplifier (FRA) (Type I) and in post-compensation technique; the DCF is used after FRA (Type II) in a WDM optical communication system. The pumped dispersion shifted fiber (DSF) is in use to act as FRA amplifier. The performance characteristics such as Q factor, BER and eye closure penalty are premeditated to realize the ultra high speed WDM systems by employing DCF based FRA together with DPSK modulation. From simulated results, it is recommended to implement Type I over Type II to realize the feasibility of such high speed WDM systems.

Sharma, Vishal; Gautam, Sunil

2013-12-01

298

Global forest cover mapping for the United Nations Food and Agriculture Organization forest resources assessment 2000 program  

USGS Publications Warehouse

Many countries periodically produce national reports on the status and changes of forest resources, using statistical surveys and spatial mapping of remotely sensed data. At the global level, the Food and Agriculture Organization (FAO) of the United Nations has conducted a Forest Resources Assessment (FRA) program every 10 yr since 1980, producing statistics and analysis that give a global synopsis of forest resources in the world. For the year 2000 of the FRA program (FRA2000), a global forest cover map was produced to provide spatial context to the extensive survey. The forest cover map, produced at the U.S. Geological Survey (USGS) EROS Data Center (EDC), has five classes: closed forest, open or fragmented forest, other wooded land, other land cover, and water. The first two forested classes at the global scale were delineated using combinations of temporal compositing, modified mixture analysis, geographic stratification, and other classification techniques. The remaining three FAO classes were derived primarily from the USGS global land cover characteristics database (Loveland et al. 1999). Validated on the basis of existing reference data sets, the map is estimated to be 77% accurate for the first four classes (no reference data were available for water), and 86% accurate for the forest and nonforest classification. The final map will be published as an insert to the FAO FRA2000 report.

Zhu, Z.; Waller, E.

2003-01-01

299

1 Crystal Engineering Using a "Turtlebug" Algorithm: A de Novo 2 Approach to the Design of Binodal MetalOrganic Frameworks  

E-print Network

fra- 10 meworks (MOFs) or porous coordination polymers (PCPs) 11 over the past two decades has conductivity, and catalytic activity.1f?h,m,p?u The fact that 19 MOFs are amenabled prior to design generating such designs, and we present output from two 27 demonstration programs based on this algorithm

Clark, W. Edwin

300

Cancer Cell Protein Kinase C a Is a Central Signaling Node  

E-print Network

, respectively. PKCa and FRA1 expression is associated with the aggressive triple-negative breast cancers for Breast Cancer Stem Cells Wai Leong Tam,1,8 Haihui Lu,1 Joyce Buikhuisen,1 Boon Seng Soh,2 Elgene Lim,3 of breast cancer, several Significance Conventional cancer therapeutics tend to preferentially eliminate

Liu, Xiaole Shirley

301

RESEARCH ARTICLE Open Access Expression of activator protein-1 (AP-1) family  

E-print Network

. We aimed to assess the potential role of AP-1 family members as novel biomarkers in breast cancer was significantly higher in triple-negative tumors compared with luminal carcinomas (p = 0.01). Conclusions: Expression levels of Fra-1 and Jun-B might be possible biomarkers for prognosis of breast cancer. Keywords

Carter, Ashley

302

Ontology-Driven Health Information  

Microsoft Academic Search

Following an architecture vision such as the Generic Component Model (GCM) architecture fra mework, health information systems for supporting personalized care have to be based on a component-oriented architecture. Representing concepts and their interrelations, the GCM perspectives syste m architecture, domains, and development process can be described by the domains' ontologies. The paper introduces ontology principles, ontology references to the

Bernd BLOBEL; Frank OEMIG

2009-01-01

303

Using Clovers as Living Mulches To Boost Yields, Suppress Pests, and Augment Spiders in a Broccoli Agroecosystem  

Microsoft Academic Search

Summary A field study was conducted to examine the influence of intercropping broccoli (Brassica oleracea L.) with three living mulches on caterpillar pest and spider densities and crop yield. Broccoli was grown in bare ground or intercropped with strawberry clover (Trifolium fra- giferum L.), white clover (Trifolium repens L.), or yel- low sweetclover (Melilotus officinalis L.). Lepidopteran (butterfly and moth)

Cerruti R; Raju R. Pandey; Marshall W. Johnsonc

304

32 Astronomi 5/13 Sigurd Enebo  

E-print Network

Einbu å følge stjernen Aur ved å sammenligne dens lys- styrke med Aur (visuell størrelsesklasse 3,47), Aur (3,86) og Per (3,16). Referan- severdiene fikk han fra en fotometrisk katalog utarbeidet ved observatoriet i Potsdam. Gene- ral Catalogue of Variable Stars, heretter benevnt GCVS(2012), angir at Aur er en

Løw, Erik

305

I lande med currency boards bygger pengepolitikken p, at den inden- landske pengebase  

Microsoft Academic Search

1 skal vre fuldt dkket af udenlandsk valuta og guld. Under en streng fortolkning af reglen m den ansvarlige myndig- hed ikke erhverve indenlandske finansielle aktiver, hvilket betyder, at pengebasen tilpasser sig til valutareserven. Samtidig skal enhver frit og uden begrnsninger kunne veksle til og fra en ankervaluta til en fastsat kurs. Princippet er lovfstet, og kan sledes kun ndres

Ulrik Bie; Peter Hahnemann

1999-01-01

306

49 CFR 214.503 - Good-faith challenges; procedures for notification and resolution.  

Code of Federal Regulations, 2010 CFR

...SAFETY On-Track Roadway Maintenance Machines and Hi-Rail Vehicles 214.503...operating an on-track roadway maintenance machine or hi-rail vehicle shall inform the...a good-faith determination that the machine or vehicle does not comply with FRA...

2010-10-01

307

49 CFR 214.503 - Good-faith challenges; procedures for notification and resolution.  

Code of Federal Regulations, 2011 CFR

...SAFETY On-Track Roadway Maintenance Machines and Hi-Rail Vehicles 214.503...operating an on-track roadway maintenance machine or hi-rail vehicle shall inform the...a good-faith determination that the machine or vehicle does not comply with FRA...

2011-10-01

308

49 CFR 214.503 - Good-faith challenges; procedures for notification and resolution.  

Code of Federal Regulations, 2012 CFR

...SAFETY On-Track Roadway Maintenance Machines and Hi-Rail Vehicles 214.503...operating an on-track roadway maintenance machine or hi-rail vehicle shall inform the...a good-faith determination that the machine or vehicle does not comply with FRA...

2012-10-01

309

49 CFR 214.503 - Good-faith challenges; procedures for notification and resolution.  

Code of Federal Regulations, 2013 CFR

...SAFETY On-Track Roadway Maintenance Machines and Hi-Rail Vehicles 214.503...operating an on-track roadway maintenance machine or hi-rail vehicle shall inform the...a good-faith determination that the machine or vehicle does not comply with FRA...

2013-10-01

310

49 CFR Appendix B to Part 242 - Procedures for Submission and Approval of Conductor Certification Programs  

Code of Federal Regulations, 2013 CFR

...periodically. Each railroad needs to advise FRA how that need is satisfied in terms...authorized to work over. In addition to stating how long a conductor must be absent...railroads will be given discretion to determine how many times a conductor must...

2013-10-01

311

49 CFR Appendix B to Part 242 - Procedures for Submission and Approval of Conductor Certification Programs  

Code of Federal Regulations, 2012 CFR

...periodically. Each railroad needs to advise FRA how that need is satisfied in terms...authorized to work over. In addition to stating how long a conductor must be absent...railroads will be given discretion to determine how many times a conductor must...

2012-10-01

312

75 FR 45197 - Notice of Buy America Waiver Request by Northern New England Passenger Rail Authority To Purchase...  

Federal Register 2010, 2011, 2012, 2013

...Federal Railroad Administration Notice of Buy America Waiver Request by Northern New England...Transportation (DOT). ACTION: Notice of Buy America waiver request and request for comment...NNEPRA) is seeking a waiver from FRA's Buy America requirement--49 U.S.C....

2010-08-02

313

A fragile site in the X chromosome of the reindeer (Rangifer tarandus L)  

E-print Network

A fragile site in the X chromosome of the reindeer (Rangifer tarandus L) U Gripenberg S Huuhtanen M; 2Finnish Game and Fisheries Research Institute, Reindeer Research, SF-96100 Rovaniemi, Finland 1990) fraX / fragile site / reindeer / BrdU induction INTRODUCTION During an investigation

Paris-Sud XI, Université de

314

Program Evaluation Briefing: FloridaTrespass Prevention ResearchStudy  

E-print Network

Secretary for Research and Technology John A. Volpe National Transportation Systems Center August 5, 2014 Research Study (TPRS) Implemented by Volpe from 2009 ­ 2013 in West Palm Beach, Florida Purpose: develop benefits, best practices and lessons learned FRA R&D Director asked Volpe to evaluate project to Collect

Illinois at Urbana-Champaign, University of

315

RAILROAD ACCIDENT RATES FOR USE IN TRANSPORTATION RISK ANALYSIS  

Microsoft Academic Search

Annual safety statistics published by FRA provide train accident counts for various groupings, such as railroad, accident type, cause, track type and class, train length, and speed. However, hazardous materials transportation risk analysis often requires more detailed accident rate statistics for specific combinations of these groupings. The statistics that are presented enable more precise determination of the probability that Class

Robert T Anderson; Christopher P. L. Barkan

2004-01-01

316

The Economic and Social Impact of Railroad Incidents: Prevent Tragedy on the Tracks  

E-print Network

The Economic and Social Impact of Railroad Incidents: Prevent Tragedy on the Tracks "Safety is Good someone is hit by a train resulting in a serious injury or death. · The FRA Railroad Safety Statistics Trains a day (296 Saturday trains & 163 Sunday trains) Metra Overview #12;Tenant Railroads · Amtrak

Illinois at Urbana-Champaign, University of

317

Visual Monitoring of Railroad Grade Crossing Yaser Sheikh, Yun Zhai, Khurram Shafique, and Mubarak Shah  

E-print Network

Visual Monitoring of Railroad Grade Crossing Yaser Sheikh, Yun Zhai, Khurram Shafique, and Mubarak Administration (NHTSA) and Federal Railroad Administration (FRA). From 1993 to 1998, there were over 25, bikers, animals and vehicles at railroad intersections. The video is processed for the detection

Treuille, Adrien

318

49 CFR 232.207 - Class IA brake tests-1,000-mile inspection.  

Code of Federal Regulations, 2010 CFR

...shall furnish to the Federal Railroad Administration upon request...each location designated. A railroad shall notify FRA's Associate...train operations, such as a derailment or other unusual circumstance...operation of the train, the railroad is not required to...

2010-10-01

319

49 CFR 232.207 - Class IA brake tests-1,000-mile inspection.  

Code of Federal Regulations, 2012 CFR

...shall furnish to the Federal Railroad Administration upon request...each location designated. A railroad shall notify FRA's Associate...train operations, such as a derailment or other unusual circumstance...operation of the train, the railroad is not required to...

2012-10-01

320

1 Copyright 2014 by ASME SEMI-QUANTITATIVE RISK ASSESSMENT OF ADJACENT TRACK ACCIDENTS ON  

E-print Network

of the most important concerns. ATArefers to train accident scenarios where a derailed equipment intrudes, and railroad crossings. Limited literature is available that addressed the risk of ATA for shared-use rail ATA: Adjacent Track Accident CFS: Consequence Factor Score FRA: Federal Railroad Administration IFS

Barkan, Christopher P.L.

321

76 FR 55819 - Track Safety Standards; Concrete Crossties  

Federal Register 2010, 2011, 2012, 2013

...4\\ For example, the railroads have a range of crosstie spacing...be field-verified. The railroad industry did not want to be...identifying locations of greatest derailment risk. It has been FRA's...deterioration. It is up to the railroad whether it will use rail...

2011-09-09

322

75 FR 61561 - Petition for Waiver of Compliance  

Federal Register 2010, 2011, 2012, 2013

...of relief. Sierra Northern Railroad Company [Waiver Petition...FRA-2010-0129] The Sierra Northern Railroad Company (SERA) seeks a waiver...certain provisions of the Railroad Freight Car Safety Standards...been an equipment-related derailment of any SERA tourist or...

2010-10-05

323

49 CFR 232.207 - Class IA brake tests-1,000-mile inspection.  

Code of Federal Regulations, 2011 CFR

...shall furnish to the Federal Railroad Administration upon request...each location designated. A railroad shall notify FRA's Associate...train operations, such as a derailment or other unusual circumstance...operation of the train, the railroad is not required to...

2011-10-01

324

The deployable gage restraint measurement system - description and operational performance  

Microsoft Academic Search

This paper presents a new generation gage restraint measurement system (GRMS) recently developed by ENSCO, Inc. and Plasser American Corporation for delivery to the Federal Railroad Administration (FRA), Office of Research and Development. The original GRMS technology was developed in the early 1980's as a performance-based method to evaluate ties and fasteners. The technology has been adopted by many railroads,

J. A. Bloom; Sung Lee

2005-01-01

325

Analysis of Major Derailment Causes on Heavy Haul Railways in the United States X.Liu, M.R. Saat, C.P.L. Barkan  

E-print Network

for the greatest risk. In this paper, freight-train derailment data from Federal Railroad Administration (FRA) of U1 Analysis of Major Derailment Causes on Heavy Haul Railways in the United States X.Liu, M.R. Saat-Champaign, Urbana, IL, USA Abstract Train derailments may cause damages to railway infrastructure, rolling stock

Barkan, Christopher P.L.

326

Transportation Research Record: Journal of the Transportation Research Board, No. 2289, Transportation Research Board of the National Academies, Washington,  

E-print Network

accident occurrence in the most cost-effective manner possible. Train derailment data from the FRA rail for frequency of occurrence by cause and number of cars derailed. Statistical analyses were conducted to examine the effects of accident cause, type of track, and derailment speed. The analysis showed that broken rails

Barkan, Christopher P.L.

327

Consulting Services Dr. Andrew Kish  

E-print Network

causal factorsStage Track Lateral Stability Mechanism PP LL VV Managing the Stress State on the Railroad MAINLINE TRACK (2010-2013) Track/Derailment/Main (through November, 2013) 3.652.014T002 Washout.Accident Cause [T-Codes: 65 Total] FRA Track Failure Caused Derailment Statistics #1 #12 CWR Stress Management

Barkan, Christopher P.L.

328

78 FR 76191 - Operational Tests and Inspections for Compliance With Maximum Authorized Train Speeds and Other...  

Federal Register 2010, 2011, 2012, 2013

...and those imposed by a railroad's own operating rules...Metro-North Spuyten Duyvil Derailment On Sunday, December...safety of the Nation's railroads, their employees...FRA recommends that railroads do each of the following...2013, Spuyten Duyvil derailment with each of their...

2013-12-16

329

78 FR 11236 - Positive Train Control Public Forum  

Federal Register 2010, 2011, 2012, 2013

...collisions and over-speed derailments caused by operational errors...position after completing work at railroad sidings. The NTSB has repeatedly...act requires each Class I railroad over which poison- or toxic-by-inhalation...December 31, 2015. The Federal Railroad Administration (FRA)...

2013-02-15

330

49 CFR 232.207 - Class IA brake tests-1,000-mile inspection.  

Code of Federal Regulations, 2013 CFR

...shall furnish to the Federal Railroad Administration upon request...each location designated. A railroad shall notify FRA's Associate...train operations, such as a derailment or other unusual circumstance...operation of the train, the railroad is not required to...

2013-10-01

331

Field testing and monitoring of rolling stock under the new federal track and equipment regulations  

Microsoft Academic Search

The Federal Railroad Administration (FRA) has issued two significant new regulations covering the qualification and operation of passenger railroad equipment. The 1998 Track Safety Standards and 1999 Passenger Equipment Safety Standards provide comprehensive requirements for the qualification and operation of passenger equipment. Among many safety issues, these standards address the response of rolling stock at speed to track deviations, and

Edward J. Lombardi; E. Sherrock; D. C. Warner; B. T. Whitten

2002-01-01

332

Hazardous materials car placement in a train consist. Volume 1. Review and analysis. Final report, 18 Feb17 Nov 88  

Microsoft Academic Search

In response to major derailments involving hazardous materials cars, the Federal Railroad Administration (FRA) initiated the review of the consequences of hazardous materials car placement in a train consist. The review and analysis consisted of six task items: (1) review of accident trends and regulations, (2) an analysis of hazardous materials compatibility, (3) railroad operational constraints, (4) a cost\\/benefit analysis,

R. E. Thompson; E. R. Zamejc; D. R. Ahlbeck

1992-01-01

333

CEESCENTER for ENVIRONMENTALand ESTUARINESTUDIES UN/VRS/TYof MARYLAND SYSTEM  

E-print Network

CEESCENTER for ENVIRONMENTALand ESTUARINESTUDIES UN/VRS/TYof MARYLAND SYSTEM USA LEVEL ONE REPORT MARYLAND DEPARTMENT OF THE ENVIRONMENT MARYLAND CHESAPEAKE BAY WATER QUALITY MONITORING PROGRAMProgram R.M. Stankelisl Sr FRA, FieldProgram Universityof MarylandSystem Center for Environmental& Estuarine

Boynton, Walter R.

334

49 CFR 225.37 - Magnetic media transfer and electronic submission.  

Code of Federal Regulations, 2010 CFR

...F 6180.99); and (3) A notarized hard copy of the Railroad Injury and Illness...FRA-designated computer; and (2) A notarized hard copy of the Railroad Injury and Illness...electronic submission option, shall submit the hard copy report(s) for each...

2010-10-01

335

Social Security SS wage base $106,800  

E-print Network

Social Security SS wage base $106,800 FICA tax rate--employee4 7.65% SECA tax rate,680 (Applies only to earnings for months prior to attaining FRA) Social Security cost-of-living adjustment 0 days (lifetime reserve days) patient pays per day $550 Skilled nursing benefits First 20 days

Boyer, Elizabeth W.

336

www.online.shop Projektbeteiligte  

E-print Network

CHECKLISTE www.online.shop Projektbeteiligte Fachgebiet Informationssysteme Externer Partner den Kulissen von Online-Shops Warenkataloge untersuchen und aufbereiten UntersUchen: Durch das Filtern aufbereitete Warenkatalog kann nun verwendet werden, um mit Hilfe eines Online-Beraters gezielt Fra- gen an den

Weske, Mathias

337

Original article Expression of X chromosome fragility  

E-print Network

Original article Expression of X chromosome fragility in Holstein-Friesian cattle: a preliminary-Friesian cows were cytogenetically examined, focusing on Xq 3.1 fragility manifestation (Fra Xq). Comparative fragility detected in TC 199 was 0.9% while in RPMI 1640 it was 1.8% (0.05 > P > 0.01). According

Paris-Sud XI, Université de

338

Glass of Kir Royale (125ml) 3,95 blanc de blancs brut with cassis  

E-print Network

Marinières 5,95 mussels cooked with white wine, garlic, shallots, parsley and fresh cream Smoked Salmon 6,50 sliced smoked Scottish salmon with dill, shallots, baby capers and crème fraîche dressing Steak Tartare 6,75 finely chopped raw beef mixed with shallots, capers, cornichons, egg yolk and cognac Goats Cheese Tartine

Bearhop, Stuart

339

76 FR 80781 - Alcohol and Drug Testing: Determination of Minimum Random Testing Rates for 2012  

Federal Register 2010, 2011, 2012, 2013

...FRA-2001-11213, Notice No. 15] RIN 2130-AA81 Alcohol and Drug Testing: Determination of Minimum...addition, because the industry-wide random alcohol testing violation rate has remained below...has determined that the minimum random alcohol testing rate will remain at 10...

2011-12-27

340

77 FR 75896 - Alcohol and Drug Testing: Determination of Minimum Random Testing Rates for 2013  

Federal Register 2010, 2011, 2012, 2013

...FRA-2001-11213, Notice No. 16] Alcohol and Drug Testing: Determination of Minimum...addition, because the industry-wide random alcohol testing violation rate has remained below...has determined that the minimum random alcohol testing rate will remain at 10...

2012-12-26

341

78 FR 78275 - Alcohol and Drug Testing: Determination of Minimum Random Testing Rates for 2014  

Federal Register 2010, 2011, 2012, 2013

...FRA-2001-11213, Notice No. 17] Alcohol and Drug Testing: Determination of Minimum...addition, because the industry-wide random alcohol testing violation rate has remained below...has determined that the minimum random alcohol testing rate will remain at 10...

2013-12-26

342

49 CFR 229.27 - Annual tests.  

Code of Federal Regulations, 2012 CFR

...Form FRA F 6180-49A, and the person conducting the test and that person's supervisor shall sign the form. (c) A microprocessor-based event recorder with a self-monitoring feature equipped to verify that all data elements required by this...

2012-10-01

343

49 CFR 229.27 - Annual tests.  

Code of Federal Regulations, 2013 CFR

...Form FRA F 6180-49A, and the person conducting the test and that person's supervisor shall sign the form. (c) A microprocessor-based event recorder with a self-monitoring feature equipped to verify that all data elements required by this...

2013-10-01

344

OPENING PLENARY SECOND PLENARY THIRD PLENARYWater Crisis Global Health Governance  

E-print Network

OPENING PLENARY SECOND PLENARY THIRD PLENARYWater Crisis Global Health Governance Marjorie GriffinOpOliS experience Associate Dean, Research, Director of Global Health and Professor in the Faculty of Health Sciences SiMon FraSer UniverSity Professor of Global Health Policy London SChooL oF hyGiene and tropi

Haykin, Simon

345

Further segregation analysis of the fragile X syndrome with special reference to transmitting males  

Microsoft Academic Search

A new series of 96 pedigrees with the fra(X) syndrome was analysed using complex segregation analysis with pointers, defining affection as any degree of mental impairment. These families were found to exhibit the same segregation pattern as the first series of 110 pedigrees (Sherman et al. 1984). The best estimate for penetrance of mental impairment in males was 79% and

S. L. Sherman; P. A. Jacobs; N. E. Morton; U. Froster-Iskenius; P. N. Howard-Peebles; K. B. Nielsen; M. W. Partington; G. R. Sutherland; G. Turner; M. Watson

1985-01-01

346

60 FR 53133 - Qualifications for Locomotive Engineers; and, Railroad Safety Enforcement...  

Federal Register 2010, 2011, 2012, 2013

...Procedural Changes to Accommodate FRA Hearing Officers AGENCY: Federal Railroad Administration...the procedures that will be employed in hearings involving the determination of an individual's...shall apply as of that date to all future hearings and to review of all hearings...

1995-10-12

347

MODELING OF SPINEL SETTLING IN WASTE GLASS MELTER  

EPA Science Inventory

The topic of this multi-institutional bi-national research is the formation and settling of spinel, the most common crystalline phase that precipitates in molten high-level waste HLW) glass. For the majority of HLW streams, spinel formation in the HLW melter limits the waste fra...

348

Lack of association between mutation size and cognitive/behavior deficits in fragile X males: a brief report.  

PubMed

Previously, researchers reported molecular-neurobehavioral or molecular-cognitive associations in individuals with fra(X) (fragile X) mutation. However, not all investigators have noted molecular-behavioral relationships. Consequently, we examined prospectively 30 fra(X) males age 3-15 years from four testing sites to determine whether there was a relationship between mutation size and degree of either cognitive or adaptive behavior deficit. To measure cognitive abilities, all individuals were administered the Stanford-Binet (4th edition) IQ test. To evaluate adaptive behavior (DQ) skills, all individuals were assessed using the Vineland Adaptive Behavior Scale. To determine fra(X) status, genomic DNA from all individuals was extracted and digested with EcoRI and EagI restriction enzymes. Southern blots were prepared and hybridized with the pE5.1 probe. The Pearson correlation coefficient between full mutation size and composite IQ score revealed a nonsignificant, near-zero association (r = 0.06; P > .76). The Pearson coefficient between mutation size and DQ also showed a nonsignificant, near-zero association (r = 0.06; P > .73). We conclude that while fra(X) mutation produces cognitive and behavior deficits in males who inherit the defective gene, there is no relationship between mutation size and degree of deficit. PMID:8844081

Fisch, G S; Carpenter, N; Howard-Peebles, P N; Maddalena, A; Simensen, R; Tarleton, J; Julien-Inalsingh, C; Chalifoux, M; Holden, J J

1996-08-01

349

77 FR 12407 - Statement of Agency Policy and Interpretation on the Hours of Service Laws as Amended; Response...  

Federal Register 2010, 2011, 2012, 2013

...must give the employee off duty before the employee may go on duty again. In issuing this interpretation, FRA...Limitations on Time on Duty in a May not remain or go on May not remain or go on May not remain or go on Single Tour. duty in...

2012-02-29

350

PhD, Computer Science and Engineering, University of South Florida, 2002. MSC (Engg.), Electrical Engineering, Indian Institute of Science, India, 1994.  

E-print Network

Florida campus, February, 2013. · General Co-Chair of "1st Workshop On Design And Test Methodologies For Emerging Technologies" Co-located with IEEE European Test Symposium, Avignon (France), May 31, 2013 of BEST Robotics Program, IEEE RAS Chapter, Tampa Bay, 2013. · Member of Florida Robotics Alliance (FRA

Bhanja, Sanjukta

351

Focal Retrograde Amnesia: Voxel-Based Morphometry Findings in a Case without MRI Lesions  

PubMed Central

Focal retrograde amnesia (FRA) is a rare neurocognitive disorder presenting with an isolated loss of retrograde memory. In the absence of detectable brain lesions, a differentiation of FRA from psychogenic causes is difficult. Here we report a case study of persisting FRA after an epileptic seizure. A thorough neuropsychological assessment confirmed severe retrograde memory deficits while anterograde memory abilities were completely normal. Neurological and psychiatric examination were unremarkable and high-resolution MRI showed no neuroradiologically apparent lesion. However, voxel-based morphometry (VBM)-comparing the MRI to an education-, age-and sex-matched control group (n?=?20) disclosed distinct gray matter decreases in left temporopolar cortex and a region between right posterior parahippocampal and lingual cortex. Although the results of VBM-based comparisons between a single case and a healthy control group are generally susceptible to differences unrelated to the specific symptoms of the case, we believe that our data suggest a causal role of the cortical areas detected since the retrograde memory deficit is the preeminent neuropsychological difference between patient and controls. This was paralleled by grey matter differences in central nodes of the retrograde memory network. We therefore suggest that these subtle alterations represent structural correlates of the focal retrograde amnesia in our patient. Beyond the implications for the diagnosis and etiology of FRA, our results advocate the use of VBM in conditions that do not show abnormalities in clinical radiological assessment, but show distinct neuropsychological deficits. PMID:22028902

Sehm, Bernhard; Frisch, Stefan; Thne-Otto, Angelika; Horstmann, Annette; Villringer, Arno; Obrig, Hellmuth

2011-01-01

352

Two Cases of Functional Focal Retrograde Amnesia with Impairment of Object Use  

Microsoft Academic Search

We report on two patients, TH and KN, with focal retrograde amnesia (FRA). Their memory loss regarding life events extended to their whole lives, whereas they could acquire and retain new information. They also showed prominent deficits in production and comprehension of common words. In addition, at least in the testing situation, they were impaired in their recognition and use

Hikaru Nakamura; Yoko Kunori; Kayoko Mori; Shutaro Nakaaki; Shinichi Yoshida; Toshihiko Hamanaka

2002-01-01

353

Focal Retrograde Amnesia: Voxel-Based Morphometry Findings in a Case without MRI Lesions  

E-print Network

Focal retrograde amnesia (FRA) is a rare neurocognitive disorder presenting with an isolated loss of retrograde memory. In the absence of detectable brain lesions, a differentiation of FRA from psychogenic causes is difficult. Here we report a case study of persisting FRA after an epileptic seizure. A thorough neuropsychological assessment confirmed severe retrograde memory deficits while anterograde memory abilities were completely normal. Neurological and psychiatric examination were unremarkable and high-resolution MRI showed no neuroradiologically apparent lesion. However, voxel-based morphometry (VBM)-comparing the MRI to an education-, age-and sex-matched control group (n = 20) disclosed distinct gray matter decreases in left temporopolar cortex and a region between right posterior parahippocampal and lingual cortex. Although the results of VBM-based comparisons between a single case and a healthy control group are generally susceptible to differences unrelated to the specific symptoms of the case, we believe that our data suggest a causal role of the cortical areas detected since the retrograde memory deficit is the preeminent neuropsychological difference between patient and controls. This was paralleled by grey matter differences in central nodes of the retrograde memory network. We therefore suggest that these subtle alterations represent structural correlates of the focal retrograde amnesia in our patient. Beyond the implications for the diagnosis and etiology of FRA, our results advocate the use of VBM in conditions that do not

Bernhard Sehm; Stefan Frisch; Angelika Thne-otto; Annette Horstmann; Arno Villringer; Hellmuth Obrig

2011-01-01

354

Functional focal retrograde amnesia: lost access to abstract autobiographical knowledge?  

PubMed

We describe three patients exhibiting an acute reversible amnesia characterised by an impaired recollection of past events with preserved anterograde memory, thus consistent with a focal retrograde amnesia (FRA). This occurred after variable events: state of fugue, road accident, post-traumatic headache. Retrograde amnesia affected autobiographical memory so severely as to cover all of the patients' lives and to erase knowledge of their own identity. The retrieval of public events was variably affected, ranging from normality to severe impairment. No lesions were found on neuroimaging, and neurophysiological findings were unimpressive. FRA subsided in a few days, leaving a gap for the onset. The hypothesis of a psychogenic amnesia is considered, but overcoming the organic/psychogenic dichotomy the episodes appear as examples of "functional" memory inhibition, potentially triggered by different conditions, including events classifiable as psychic trauma. The clinical and neuropsychological traits of functional FRA are discussed. According to a current theory of autobiographical memory, the memory profile may be explained by a lost access to abstract autobiographical knowledge. Given some analogies with the more common transient global amnesia, a mechanism of spreading depression may also be hypothesised for functional FRA. PMID:16191819

Stracciari, Andrea; Mattarozzi, Katia; Fonti, Cristina; Guarino, Maria

2005-10-01

355

Functional focal retrograde amnesia: Lost access to abstract autobiographical knowledge?  

Microsoft Academic Search

We describe three patients exhibiting an acute reversible amnesia characterised by an impaired recollection of past events with preserved anterograde memory, thus consistent with a focal retrograde amnesia (FRA). This occurred after variable events: state of fugue, road accident, post-traumatic headache. Retrograde amnesia affected autobiographical memory so severely as to cover all of the patients' lives and to erase knowledge

Andrea Stracciari; Katia Mattarozzi; Cristina Fonti; Maria Guarino

2005-01-01

356

Transient Global Amnesia and Functional Retrograde Amnesia: Contrasting Examples of Episodic Memory Loss  

Microsoft Academic Search

We studied 11 patients with transient global amnesia (TGA) and ten patients with functional retrograde amnesia (FRA). Patients with TGA had a uniform clinical picture: a severe, relatively isolated amnesic syndrome that started suddenly, persisted for 4-12 h, and then gradually improved to essentially normal over the next 12-24 h. During the episode, the patients had severe anterograde amnesia for

Mark Kritchevsky; Joyce Zouzounis; Larry R. Squire

1997-01-01

357

Focal retrograde amnesia: voxel-based morphometry findings in a case without MRI lesions.  

PubMed

Focal retrograde amnesia (FRA) is a rare neurocognitive disorder presenting with an isolated loss of retrograde memory. In the absence of detectable brain lesions, a differentiation of FRA from psychogenic causes is difficult. Here we report a case study of persisting FRA after an epileptic seizure. A thorough neuropsychological assessment confirmed severe retrograde memory deficits while anterograde memory abilities were completely normal. Neurological and psychiatric examination were unremarkable and high-resolution MRI showed no neuroradiologically apparent lesion. However, voxel-based morphometry (VBM)-comparing the MRI to an education-, age-and sex-matched control group (n?=?20) disclosed distinct gray matter decreases in left temporopolar cortex and a region between right posterior parahippocampal and lingual cortex. Although the results of VBM-based comparisons between a single case and a healthy control group are generally susceptible to differences unrelated to the specific symptoms of the case, we believe that our data suggest a causal role of the cortical areas detected since the retrograde memory deficit is the preeminent neuropsychological difference between patient and controls. This was paralleled by grey matter differences in central nodes of the retrograde memory network. We therefore suggest that these subtle alterations represent structural correlates of the focal retrograde amnesia in our patient. Beyond the implications for the diagnosis and etiology of FRA, our results advocate the use of VBM in conditions that do not show abnormalities in clinical radiological assessment, but show distinct neuropsychological deficits. PMID:22028902

Sehm, Bernhard; Frisch, Stefan; Thne-Otto, Angelika; Horstmann, Annette; Villringer, Arno; Obrig, Hellmuth

2011-01-01

358

Su una teoria generale della misura ( r ? 1)-dimensionale in uno spazio ad r dimensioni  

Microsoft Academic Search

SuntoIn questo lavoro do una definizione della misura (r ? 1)-dimensionale della frontiera orientata di un insieme diBorel contenuto in uno spazio euclideo ad r dimensioni e dimostro alcune fra le pi notevoli propriet di tale misura.

Ennio De Giorgi

1954-01-01

359

Role of Gonadal Steroids in Determining Sexual Differences in Expression of Fos-Related Antigens in Tyrosine Hydroxylase-Immunoreactive Neurons in Subdivisions of the Hypothalamic Arcuate Nucleus  

Microsoft Academic Search

Dual immunohistochemistry was employed to examine the role of gonadal steroids in determining sexual differences in the expression of Fos and its related antigens (FRA) in tuberoinfundibular dopam- inergic (TIDA) neurons located in the dorsomedial (DM-) and ven- trolateral (VL-) subdivisions of the arcuate nucleus (ARC). In the DM-ARC, there was no sexual difference in the number of tyrosine hydroxylase

SUN CHEUNG; YVONNE M. WILL; KENNETH HENTSCHEL; KENNETH E. MOORE; KEITH J. LOOKINGLAND

1997-01-01

360

77 FR 73589 - Positive Train Control Systems (RRR)  

Federal Register 2010, 2011, 2012, 2013

...consequence should a PTC-preventable accident (PPA) result in the release of a PIH material...and other factors that may contribute to a PPA. FRA believes that placing a limit...mitigations that could be employed to bring the PPA risk down to a negligible level in...

2012-12-11

361

BANDO DI PARTECIPAZIONE al PREMIO TESI "ADRIANA CAVA" Adriana Cava Jazz Ballet in collaborazione con il DAMS di Torino, in occasione del  

E-print Network

BANDO DI PARTECIPAZIONE al PREMIO TESI "ADRIANA CAVA" Adriana Cava Jazz Ballet in collaborazione territorio nazionale, per celebrare l'attività della scuola e della compagnia di danza jazz di Adriana Cava danzatori jazz e per la divulgazione di un genere di danza e di spettacolo fra i più conosciuti e diffusi

Di Pillo, Gianni

362

75 FR 82140 - Petition for Waiver of Compliance  

Federal Register 2010, 2011, 2012, 2013

...of Class 1 yard tracks: 1. Compound fissure: Note B, no change. Note A2, change... Note A, no change. 2. Transverse fissure, detail fracture, engine burn fracture...interested party desires an opportunity for oral comment, they should notify FRA,...

2010-12-29

363

WATER WEATHERING IN ROCKS DISCONTINUITIES Sandra Dochez*1,2  

E-print Network

discontinuities and relative sliding blocks or benches [ASR05]. Runoff, which will produce mechanical erosion in the tensile strength of rock bridges fatigue [FRA05] [DRU11]. The study presented in this paper concerns and in the evolution of the cliffs. Our research aim to take into account the geomorphological features related

Paris-Sud XI, Université de

364

Fractionation of soil organic matter following long-term laboratory incubation  

Technology Transfer Automated Retrieval System (TEKTRAN)

Soil organic matter (SOM) in agricultural soils comprises a significant part of the global terrestrial C pool. It has often been characterized by utilizing a combination of chemical dispersion of the soil followed by physical separation. These fractions include a non aggregate protected, light fra...

365

49 CFR 232.15 - Movement of defective equipment.  

Code of Federal Regulations, 2010 CFR

...vi) A description of any movement restrictions; (vii) The...adequately track and monitor the movement of defective equipment. FRA...document to the railroad. (c) Movement for unloading or purging of...shall be based on the number of control valves in the train. The...

2010-10-01

366

49 CFR 232.15 - Movement of defective equipment.  

Code of Federal Regulations, 2011 CFR

...vi) A description of any movement restrictions; (vii) The...adequately track and monitor the movement of defective equipment. FRA...document to the railroad. (c) Movement for unloading or purging of...shall be based on the number of control valves in the train. The...

2011-10-01

367

Rheotactic response of fry from beach-spawning populations of sockeye salmon: evolution after  

E-print Network

for newly emerged sockeye salmon (Oncorhynchus nerka) fry from a beach population (Pleasure Point) and from rhéotaxique a été quantifiée chez des alevins fraîchement émergés du Saumon rouge (Oncorhynchus nerka) d a fluctuating element... (Darwin 1859, p. 81). Sockeye salmon (Oncorhynchus nerka) are unique among Pacific

Hendry, Andrew

368

I. Projektinformation Projekttitel  

E-print Network

#12;- 2 - I. Projektinformation Projekttitel EFP06 - Solceller integreret i industrielt byggeri,3 millioner i støtte fra Energistyrelsen gennem EFP-puljen. Yderligere information Henvendelse om projektet Formålet med projektet EFP06 - Solceller integreret i industrielt byggeri (SOL-IND) har været at undersøge

369

Projektinformation Projekttitel  

E-print Network

#12;2 I. Projektinformation Projekttitel EFP07II ­ Solceller integreret i industrialiseret #12;4 III. Indledning I det EFP-06 støttede projekt "Solceller integreret i industrielt byggeri internationale erfaringer. - Med udgangspunkt i resultaterne fra EFP06 SOL-IND projektet og det tidligere projekt

370

The rationale for B lymphocyte depletion in Graves' disease. Monoclonal anti-CD20 antibody therapy as a novel treatment option  

Microsoft Academic Search

We have reviewed the immunology of thyroid autoimmunity with special reference to the importance of B lymphocytes (B cells) in thyroidal and extrathyroidal Graves' disease (GD), thus providing a fra- mework for the hypothesis that B cell depletion may be beneficial in GD. Additionally, after reviewing the efficacy and safety in other autoimmune diseases, we propose that treatment with the

Daniel El Fassi; Claus H Nielsen; Hans C Hasselbalch; Laszlo Hegedus

2006-01-01

371

16 Research Activities 2011 Research Frontiers  

E-print Network

.icems.kyoto-u.ac.jp/e/pr/2011/02/07-nr.html Shining New Light on Air Pollutants Using Entangled Porous Fra School of Science and iCeMS Masayuki Endo [right] ­ iCeMS In a complex feat of nanoengineering, a team

Takada, Shoji

372

Genome-wide profiling of AP-1-regulated transcription provides insights into the invasiveness of triple-negative breast cancer.  

PubMed

Triple-negative breast cancer (TNBC) is an aggressive clinical subtype accounting for up to 20% of all breast cancers, but its malignant determinants remain largely undefined. Here, we show that in TNBC the overexpression of Fra-1, a component of the transcription factor AP-1, offers prognostic potential. Fra-1 depletion or its heterodimeric partner c-Jun inhibits the proliferative and invasive phenotypes of TNBC cells in vitro. Similarly, RNAi-mediated attenuation of Fra-1 or c-Jun reduced cellular invasion in vivo in a zebrafish tumor xenograft model. Exploring the AP-1 cistrome and the AP-1-regulated transcriptome, we obtained insights into the transcriptional regulatory networks of AP-1 in TNBC cells. Among the direct targets identified for Fra-1/c-Jun involved in proliferation, adhesion, and cell-cell contact, we found that AP-1 repressed the expression of E-cadherin by transcriptional upregulation of ZEB2 to stimulate cell invasion. Overall, this work illuminates the pathways through which TNBC cells acquire invasive and proliferative properties. PMID:24830720

Zhao, Chunyan; Qiao, Yichun; Jonsson, Philip; Wang, Jian; Xu, Li; Rouhi, Pegah; Sinha, Indranil; Cao, Yihai; Williams, Cecilia; Dahlman-Wright, Karin

2014-07-15

373

IEA-Renewable Energy Technologies, Bioenergy Agreement Task 37: Energy from Biogas and Landfill Gas  

E-print Network

EFP-06 IEA- Renewable Energy Technologies, Bioenergy Agreement Task 37: Energy from Biogas-Bioenergy, Task 37- Energy from Biogas and Landfill Gas", via samarbejde, informationsudveksling, fælles analyser. biogas fra anaerob udrådning (AD) som en integreret gylle og affalds behandlings teknologi. Arbejdet

374

AFSLUTNINGSRAPPORT Journal nr. 33031-0066  

E-print Network

ethanol. Endelig er det testet at øge konceptets udbytte ved at producere biogas fra resten af det af gærceller. Fermentering (Xylose) Fermentering (Glucose) Fast brændstof Biogas proces ForbehandlingBiomasse BIOGAS ETHANOL Proces vand H2 Vådoxidation Enzymatisk hydrolysis + C6 fermentering Destillation Anaerob

375

Mutation frequencies of Xlinked mental retardation genes in families from the EuroMRX consortium.  

E-print Network

Mutation frequencies of Xlinked mental retardation genes in families from the EuroMRX consortium Xlinked mental retardation (XLMR). After exclusion of Fragile X (Fra X) syndrome, probands from carriers, the mental retardation phenotype could be explained by a mutation. There was no difference

Institut des Sciences Cognitives, CNRS

376

The Fragile X Mental Retardation Protein in Circadian Rhythmicity and Memory Consolidation  

E-print Network

The Fragile X Mental Retardation Protein in Circadian Rhythmicity and Memory Consolidation Cheryl L. The fragile X mental retardation protein (FMRP), an RNA- binding translational regulator, is a key player causes fragile X syndrome (FraX), the most commonly inherited form of mental retardation and autism

Broadie, Kendal S.

377

Fathoming fragile X in fruit flies Yong Q. Zhang and Kendal Broadie  

E-print Network

37235-1634, USA Fragile X syndrome (FraX) is the most common inherited mental retardation disease. It is caused by mutation of the fragile X mental retardation 1 (fmr1) gene. The FMR1 protein (FMRP) is a widely that loss of function is causative. The fragile X mental retardation 1 (fmr1) gene was identified in 1991 [3

Broadie, Kendal S.

378

Richard P. Vlosky1 , Todd Shupe, Qinglin Wu  

E-print Network

in evaluating whether to buy or build homes that are built with termite resistant building materials. The sample fra- me for this study consisted of a random sample of 5.000 home owners in the region where Formosan Shiraki, are found throughout the tropical and temperate regions of the world, but they are more prevalent

379

Priv.-Doz. Dr. Thomas DreibholzForsker og utvikler av datanettverk Personlige opplysninger  

E-print Network

://www.iem.uni-due.de/dreibh/rserpool/ Oktober 2002 Sertifisering som Cisco Certified Network Associate (CCNA) og Cisco Cer- tified Academy Instructor (CCAI) fra Cisco Networking Academy ved Uni- versitetet i Duisburg-Essen i Essen, Tyskland Traffic Control, nettverkssikkerhet 2002 ­ 2012 Cisco Certified Academy Instructor (CCAI) i Cisco

Dreibholz, Thomas

380

76 FR 78731 - Petition for Waiver of Compliance  

Federal Register 2010, 2011, 2012, 2013

...2011, Drake Switching Company, LLC (DSC) has petitioned the Federal Railroad Administration...petition Docket Number FRA-2011-0015. DSC seeks a waiver of compliance from certain...SWX735), which is used as a locomotive. DSC states that this shuttlewagon is...

2011-12-19

381

79 FR 36862 - Notice of Application for Approval of Railroad Safety Program Plans and Product Safety Plans  

Federal Register 2010, 2011, 2012, 2013

...dispatch system developed for operation in autonomous mode (without dispatcher intervention...FRA approved the use of TrackAccess in autonomous mode for ATN. The railroads assert...Revision 1 and PSP Revision 1, including autonomous TrackAccess operations, these...

2014-06-30

382

79 FR 36122 - Notice of Application for Approval of Railroad Safety Program Plans and Product Safety Plans  

Federal Register 2010, 2011, 2012, 2013

...dispatch system developed for operation in autonomous mode (without dispatcher intervention...FRA approved the use of TrackAccess in autonomous mode for ATN. The railroads assert...Revision 1 and PSP Revision 1, including autonomous TrackAccess operations, these...

2014-06-25

383

49 CFR 211.45 - Petitions for emergency waiver of safety rules.  

Code of Federal Regulations, 2011 CFR

...that is added to a docket. (For example, the first document submitted to the docket in 2009 will be identified as FRA-2009-XXX-1.) Thus, each petition submitted to the ERD will have a unique document number which should be identified on all...

2011-10-01

384

78 FR 44189 - Petition for Modification of Single Car Air Brake Test Procedures  

Federal Register 2010, 2011, 2012, 2013

...FRA-2013-0064] Petition for Modification of Single Car Air Brake Test Procedures In accordance...per 49 CFR 232.307 to modify the single car air brake test procedures located in AAR...System Tests for Freight Equipment-- Single Car Test, and required pursuant to 49 CFR...

2013-07-23

385

75 FR 55632 - Petition for Waiver of Compliance  

Federal Register 2010, 2011, 2012, 2013

...Standards of 49 CFR 223.11 Requirements for existing locomotives. Specifically, Railtown has petitioned FRA for a waiver for four diesel locomotives: Former U.S. Navy locomotives 613 and 612, built by Alco in 1953; former U.S....

2010-09-13

386

78 FR 65422 - Agency Request for Emergency Processing of Collections of Information Associated With Today's...  

Federal Register 2010, 2011, 2012, 2013

...calling FRA's Clearance Officer, Mr. Robert Brogan (tel. (202) 493-6292...electronically by contacting Mr. Brogan at robert.brogan@dot.gov. Comments and questions...January 1, 2008, under Title IV of the Robert T. Stafford Disaster Relief and...

2013-10-31

387

FAMILIES IN THE DIAPORTHALES: A NEW LOOK BASED ON LSU NUCLEAR RDNA  

Technology Transfer Automated Retrieval System (TEKTRAN)

The ascomycete order Diaporthales includes a number of plant pathogenic fungi, the most notorious of which is Cryphonectria parasitica, the chestnut blight fungus. Relationships among genera in the Diaporthales were evaluated as a basis for the recognition of families and to provide a taxonomic fra...

388

Studies concerning the biogenesis of natural derivatives of lysergic acid  

Microsoft Academic Search

Riassunto Dall'esame della incorporazione di possibili precursori negli alcaloidi prodotti daC. paspali eC. purpurea risulta che non vi una diretta correlazione fra la biogenesi delle catene laterali della ergometrina e dellaa-idrossietilammide dell'acido lisergico, e che l'ergometrina non un precursore dei derivati peptidici dell'acido lisergico.

A. Minghetti; F. Arcamone

1969-01-01

389

Associations between Repetitive Questioning, Resistance to Change, Temper Outbursts and Anxiety in Prader-Willi and Fragile-X Syndromes  

ERIC Educational Resources Information Center

Background: The behavioural phenotypes of Prader-Willi (PWS) and Fragile-X (FraX) syndromes both comprise repetitive behaviours with differences between the profiles. In this study we investigated the context and antecedents to the repetitive behaviours and the association with other behavioural phenotypic characteristics in order to generate

Woodcock, K.; Oliver, C.; Humphreys, G.

2009-01-01

390

75 FR 54694 - Notice of Availability of a Supplemental Draft Environmental Impact Statement for the...  

Federal Register 2010, 2011, 2012, 2013

...the DesertXpress High- Speed Passenger Train Project (Project). FRA is the lead agency...of an interstate high-speed passenger train system between Victorville, CA and Las...The DesertXpress high-speed passenger train is intended to provide reliable and...

2010-09-08

391

Distance and throughput measurements in mobile WiMAX test bed  

Microsoft Academic Search

In this paper, we present our approach of establishing a Mobile WiMAX test bed as a part of our collaborations with the Federal Railroad Administration (FRA) for studying the performance of current and upcoming broadband wireless technologies in a railroad environment. The focus is on studying the impact of mobility on the wireless system throughput for moving trains at high

Puttipong Mahasukhon; Hamid Sharif; Michael Hempel; Ting Zhou; Tao Ma

2010-01-01

392

Intercity rail-passenger car ride quality test program  

NASA Technical Reports Server (NTRS)

The Federal Railroad Administration's research and development program relating to intercity rail-passenger ride quality focuses on developing ride quality design criteria and specifications. The FRA ride quality test program and some of the techniques being used to analyze and evaluate the design criteria of the program are discussed.

Scharr, R. L.; Owings, R. P.

1975-01-01

393

77 FR 38882 - Notice of Availability of a Draft Environmental Impact Statement, for the Chicago, IL to St...  

Federal Register 2010, 2011, 2012, 2013

...Chicago, IL to St. Louis, MO High Speed Rail Corridor Program AGENCY: Federal Railroad...Illinois to St. Louis, Missouri High Speed Rail Corridor Program. The Draft EIS includes...project-level evaluation for the Springfield Rail Improvements Project. FRA is the...

2012-06-29

394

The magneto-optical properties of annealed Co96Pt4 nanowire arrays  

NASA Astrophysics Data System (ADS)

The magneto-optical (MO) properties of highly ordered arrays of electrodeposited Co96Pt4 alloy nanowires embedded in anodic aluminum oxide (AAO) membranes have been studied as a function of annealing temperature (TA). The initial measurements yielded the four Stokes parameters from which the Faraday rotation angle (FRA) and ellipticity (tan?) were extracted. The FRA was determined as 8.0103deg/cm for the as-deposited sample. After annealing at 300C the FRA attained a maximum of 1.1104deg/cm (an increase of 38%), but thereafter declined monotonically as TA was increased to 650C. The ellipticity shows a similar behavior with TA. However, the corresponding variation in saturation magnetization (Ms) with TA does not match that of the magneto-optical constants, which suggests that factors other than Ms also determine the values of FRA and tan?. The data obtained indicate that a suitable annealing regime is an effective method to optimize the MO properties of AAO-based magnetic nanowire arrays.

Li, Wuxia; Jones, Grenville A.; Peng, Yong; Shen, Tiehan H.; Hill, Geoff

2005-05-01

395

Available at www.sciencedirect.com journal homepage: www.elsevier.com/locate/psyneuen  

E-print Network

and studies of fmr1 knockout mice have led to the hypothesis that, in addition to mental retardation, fragile stress is unaltered by the lack of fragile X mental retardation protein. Published by Elsevier Ltd. 1. Introduction Fragile X syndrome (FraX), the most common inherited form of mental retardation, is caused

Smith, Carolyn Beebe

396

78 FR 14875 - Petition for Waiver of Compliance  

Federal Register 2010, 2011, 2012, 2013

...petition Docket Number FRA-2012-0092. Specifically, BNSF seeks relief with respect to 49 CFR 232.207(a) for certain Bakken-oil unit trains that originate at refineries in North Dakota. These trains, when headed east out of the refineries,...

2013-03-07

397

Naturhistorisk museum Universitetet i Oslo  

E-print Network

insektlarver fra den bløte bakken. Den lille rørsangeren holder til i takrør- skoger og lever av små insekter til april. Rugde har reiret sitt på bakken og har vernefarger som skjuler den svært godt. ?ynene

Løw, Erik

398

Determining the dispersion characteristics of rivers from the frequency response of the system  

NASA Astrophysics Data System (ADS)

A new method of determining the parameters of an aggregated dead zone model (ADZ) to predict longitudinal dispersion in rivers is presented. The method is based on the frequency response analysis (FRA) of observed field tests, which consist of tracer injections (input) and measurement of tracer in downstream sampling points (output) located downstream from the injection point. The ADZ is a combination of plug and completely mixed flow compartments. The ADZ parameters (number of compartments, mean residence time, and delay time) are evaluated by means of Bode plots that give the system order (number of compartments), gain, time constant (mean residence time of each compartment) and delay time. The FRA-ADZ method was checked with tracer data runs in two Spanish rivers, the Tagus and the Ebro rivers. The experimental tracer concentration versus time distributions were compared with the ADZ predicted curves, which were calculated using parameters obtained from the FRA method, and with curves predicted by several classical models. The residence time of several reaches within the two studied rivers was predicted by the FRA-ADZ method with a relative error lower than 10%. The method is generally applicable to ideal and nonideal inputs and is particularly well suited to arbitrary-shaped initial source concentration distributions.

Lambertz, Peter; Palancar, MarA. C.; Aragn, Jos M.; Gil, Roberto

2006-09-01

399

Inklusion og eksklusion  

Microsoft Academic Search

Begreberne differentiering og integration har en lang tradition i sociologisk teori. Sprgsmlet er imidlertid, om man ikke overbelaster dette begrebspars forklaringsevne, isr nr man str over for srlige problemer i udviklingslande og bestemte problemer, der er flles for ulande og ilande. Artiklen foreslr, at sociologien suppleres med begrebsparret inklusion\\/eksklusion. Det vises, hvordan inklusions- og eksklusionsforholdene varierer fra segmentrt over stratificeret

Niklas Luhmann

2002-01-01

400

Universit degli Studi di Genova Inaugurazione anno accademico 2008-2009  

E-print Network

erano senza dubbio vittima di uno stato di morte apparente. Allo scopo di evitare questo macabro evento sul presunto cadavere affinché la diagnosi di morte fosse certa. Fra questi, ad esempio, porre davanti il termine "morte cerebrale" in occasione del trapianto di rene eseguito prelevando gli organi di un

Genova, Università degli Studi di

401

Merguerian, Charles, 1989b, Apollo 15: in F. N. Magill, editor, Magill's Survey of Science, Space Exploration Series, Salem Press, Inc., Pasadena, California, p. 104-109.  

E-print Network

evolution of the Moon and set the stage, as an exploration prototype, for the Apollo 16 and 17 missions in the Fra Mauro area of the Moon, the Apollo 15 mission was designed to continue the United States' lunar engaged to land on the Moon and provide a seismic signal. The booster made lunar impact at 2058 GMT

Merguerian, Charles

402

THE DEPARTMENT OF INFORMATICS NO. 3 2012  

E-print Network

2013-2015 In 2013 we will celebrate the Women's Suffrage/the right to vote (100 years) In 2014 we horisontforelesningen finner sted på Darwin dagen, mandag 13. februar kl 18.00 på Kvarteret. Da er det Fred Spier fra

Fomin, Fedor V.

403

Cellular Automata and Riccati Equation Models for Diffusion of Innovations Automi Cellulari e l'Equazione di Riccati nei Modelli di Diffusione delle Innovazioni  

Microsoft Academic Search

Riassunto: La diffusione di innovazioni in un sistema socialee stata studiata in settori scientifici differenti, avendo spesso come riferimento il lavoro pionieristico di Bass (1969) fondato su un approccio aggregato differenziale. Tuttavia, il fatto che i canali di comunicazione fra persone possano avere un raggio d'azione limitato ha stimolato la modellazione di Automi Cellulari (CA). Qui si propone un'estensione del

Renato Guseo; Mariangela Guidolin

404

Multidisciplinary population monitoring when demographic data are sparse: a case study of remote trout populations  

E-print Network

history, Mistassini Lake, salmonid, traditional ecological knowledge. Correspondence Dylan J. Fraser a large, remote lake. The data revealed largely stable characteristics in two populations over 2 (Ferguson and Messier 1997; Berkes 1999; Fra- ser et al. 2006). On the other hand, while sampling of genetic

Fraser, Dylan J.

405

Multidisciplinary population monitoring when demographic data are sparse: a case study of remote trout populations  

E-print Network

history, Mistassini Lake, salmonid, traditional ecological knowledge. Correspondence Dylan J. Fraser in a socioeconomically important trout species occu- pying a large, remote lake. The data revealed largely stable or seasonally (Ferguson and Messier 1997; Berkes 1999; Fra- ser et al. 2006). O

Bernatchez, Louis

406

77 FR 64077 - National Highway-Rail Crossing Inventory Reporting Requirements  

Federal Register 2010, 2011, 2012, 2013

...crossings that have a high risk of collisions and implement measures, such...reduce the probability of a collision. Therefore, an instructions...Draft Inventory Form, Train Detection, FRA seeks comment on whether...decade there were over 26,000 collisions at grade crossing, this...

2012-10-18

407

Neurohumoral control of gastrointestinal motility Laboratoire de Biologie et Physiologie des Cellules digestives,  

E-print Network

peptides are present in both the digestive tract and the central nervous system. In spite of the work des Cellules digestives, (FRA 49 INSERM), Faculté de Médecine X Bichat, 16, rue H.-Huchard, 75018 produced a whole new collection of peptide molecules extracted from the digestive tract. Two facts

Paris-Sud XI, Université de

408

49 CFR 229.20 - Electronic recordkeeping.  

Code of Federal Regulations, 2012 CFR

...be necessary to document compliance with this part, shall be provided to FRA for inspection and copyingupon request http://web2.westlaw.com/ find/default.wl?DB=1000547&DocName= 49CFRS213%2E305&FindType=L&AP=...

2012-10-01

409

Gene, Brain, and Behavior Relationships in Fragile X Syndrome: Evidence from Neuroimaging Studies  

ERIC Educational Resources Information Center

Fragile X syndrome (FraX) remains the most common inherited cause of intellectual disability and provides a valuable model for studying gene-brain-behavior relationships. Over the past 15 years, structural and functional magnetic resonance imaging studies have emerged with the goal of better understanding the neural pathways contributing to the

Lightbody, Amy A.; Reiss, Allan L.

2009-01-01

410

A short-filament mutant of Anabaena sp. strain PCC 7120 that fragments in nitrogen-deficient medium.  

PubMed Central

Strain 129 is a fragmentation mutant of the filamentous cyanobacterium Anabaena sp. strain PCC 7120. Growing with fixed nitrogen, this mutant forms filaments that are much shorter than wild-type filaments. Following starvation for fixed nitrogen, strain 129 becomes nearly unicellular and forms few heterocysts, although electron microscopy suggests that proheterocysts form while fragmentation occurs. Starvation for sulfate, phosphate, iron, and calcium does not cause this fragmentation. The affected gene in strain 129, fraC, was cloned by complementation and characterized. It encodes a unique 179-amino-acid protein rich in phenylalanine. Insertional inactivation of the chromosomal copy of fraC results in a phenotype identical to that of strain 129, while complementation using a truncated version of FraC results in only partial complementation of the original mutant. Heterocysts could be induced to form in N-replete cultures of strain 129, as in wild-type cells, by supplying extra copies of the hetR gene on a plasmid. Thus, FraC is required for the integrity of cell junctions in general but is apparently not directly involved in normal differentiation and nitrogen fixation. PMID:7883709

Bauer, C C; Buikema, W J; Black, K; Haselkorn, R

1995-01-01

411

78 FR 41991 - Petition for Waiver of Compliance  

Federal Register 2010, 2011, 2012, 2013

...windows with a mixture of unmarked polycarbonate and automotive-type, windshield-grade...laminated safety glass. FRA Type II polycarbonate glazing is present in the vestibule's...Carbody end-door windows are unmarked polycarbonate. ELDCPS seeks relief from the...

2013-07-12

412

A chemical potentiator of copper-accumulation used to investigate the iron-regulons of Saccharomyces cerevisiae  

PubMed Central

The extreme resistance of Saccharomyces cerevisiae to copper is overcome by 2-(6-benzyl-2-pyridyl)quinazoline (BPQ), providing a chemical-biology tool which has been exploited in two lines of discovery. First, BPQ is shown to form a red (BPQ)2Cu(I) complex and promote Ctr1-independent copper-accumulation in whole cells and in mitochondria isolated from treated cells. Multiple phenotypes, including loss of aconitase activity, are consistent with copper-BPQ mediated damage to mitochondrial ironsulphur clusters. Thus, a biochemical basis of copper-toxicity in S. cerevisiae is analogous to other organisms. Second, iron regulons controlled by Aft1/2, Cth2 and Yap5 that respond to mitochondrial ironsulphur cluster status are modulated by copper-BPQ causing iron hyper-accumulation via upregulated iron-import. Comparison of copper-BPQ treated, untreated and copper-only treated wild-type and fra2? by RNA-seq has uncovered a new candidate Aft1 target-gene (LSO1) and paralogous non-target (LSO2), plus nine putative Cth2 target-transcripts. Two lines of evidence confirm that Fra2 dominates basal repression of the Aft1/2 regulons in iron-replete cultures. Fra2-independent control of these regulons is also observed but CTH2 itself appears to be atypically Fra2-dependent. However, control of Cth2-target transcripts which is independent of CTH2 transcript abundance or of Fra2, is also quantified. Use of copper-BPQ supports a substantial contribution of metabolite repression to iron-regulation. PMID:24895027

Foster, Andrew W; Dainty, Samantha J; Patterson, Carl J; Pohl, Ehmke; Blackburn, Hannah; Wilson, Clare; Hess, Corinna R; Rutherford, Julian C; Quaranta, Laura; Corran, Andy; Robinson, Nigel J

2014-01-01

413

Conceptualizing neurodevelopmental disorders through a mechanistic understanding of fragile X syndrome and Williams syndrome  

PubMed Central

Purpose of review The overarching goal of this review is to compare and contrast the cognitive-behavioral features of fragile X syndrome (FraX) and Williams syndrome and to review the putative neural and molecular underpinnings of these features. Information is presented in a framework that provides guiding principles for conceptualizing gene-brain-behavior associations in neurodevelopmental disorders. Recent findings Abnormalities, in particular cognitive-behavioral domains with similarities in underlying neurodevelopmental correlates, occur in both FraX and Williams syndrome including aberrant frontostriatal pathways leading to executive function deficits, and magnocellular/dorsal visual stream, superior parietal lobe, inferior parietal lobe, and postcentral gyrus abnormalities contributing to deficits in visuospatial function. Compelling cognitivebehavioral and neurodevelopmental contrasts also exist in these two disorders, for example, aberrant amygdala and fusiform cortex structure and function occurring in the context of contrasting social behavioral phenotypes, and temporal cortical and cerebellar abnormalities potentially underlying differences in language function. Abnormal dendritic development is a shared neurodevelopmental morphologic feature between FraX and Williams syndrome. Commonalities in molecular machinery and processes across FraX and Williams syndrome occur as well microRNAs involved in translational regulation of major synaptic proteins; scaffolding proteins in excitatory synapses; and proteins involved in axonal development. Summary Although the genetic variations leading to FraX and Williams syndrome are different, important similarities and contrasts in the phenotype, neurocircuitry, molecular machinery, and cellular processes in these two disorders allow for a unique approach to conceptualizing genebrainbehavior links occurring in neurodevelopmental disorders. PMID:22395002

Fung, Lawrence K.; Quintin, Eve-Marie; Haas, Brian W.

2013-01-01

414

The relationship between headache and religious attendance (the Nord-Trndelag health study- HUNT)  

PubMed Central

Background Religious belief can be used as a pain coping strategy. Our purpose was to evaluate the relationship between headache and religious activity using prospective data from a large population-based study. Methods This longitudinal cohort study used data from two consecutive surveys in the Nord-Trndelag Health Survey (HUNT 2 and 3) performed in 19951997; and 20062008. Among the 51,383 participants aged???20 years who answered headache questions at baseline, 41,766 were eligible approximately 11 years later. Of these, 25,177 (60%) completed the question in HUNT 3 regarding religious activity. Frequent religious attendees (fRA) (used as a marker of stronger religious belief than average) were defined as those who had been to church/prayer house at least once monthly during the last six months. Results In the multivariate analyses, adjusting for known potential confounders, individuals with headache 114days/month in HUNT 2 were more likely to be fRA 11 years later than headache-free individuals. Migraine at baseline predisposed more strongly to fRA at follow-up (OR?=?1.25; 95% CI 1.19-1.40) than did non-migrainous headache (OR?=?1.13; 95% 1.04-1.23). The odds of being fRA was 48% increased (OR 1.48; 95% 1.19-1.83) among those with migraine 714days/month at baseline compared to subjects without headache. In contrast, headache status at baseline did not influence the odds of being frequent visitors of concerts, cinema and/or theatre at follow-up 11 years later. Conclusions In this prospective study, headache, in particular migraine, at baseline slightly increased the odds of being fRA 11 years later. PMID:24386923

2014-01-01

415

Extracellular Signal-Regulated Kinase Regulates RhoA Activation and Tumor Cell Plasticity by Inhibiting Guanine Exchange Factor H1 Activity  

PubMed Central

In certain Ras mutant cell lines, the inhibition of extracellular signal-regulated kinase (ERK) signaling increases RhoA activity and inhibits cell motility, which was attributed to a decrease in Fra-1 levels. Here we report a Fra-1-independent augmentation of RhoA signaling during short-term inhibition of ERK signaling. Using mass spectrometry-based proteomics, we identified guanine exchange factor H1 (GEF-H1) as mediating this effect. ERK binds to the Rho exchange factor GEF-H1 and phosphorylates it on S959, causing inhibition of GEF-H1 activity and a consequent decrease in RhoA activity. Knockdown experiments and expression of a nonphosphorylatable S959A GEF-H1 mutant showed that this site is crucial in regulating cell motility and invasiveness. Thus, we identified GEF-H1 as a critical ERK effector that regulates motility, cell morphology, and invasiveness. PMID:24043311

von Thun, Anne; Preisinger, Christian; Rath, Oliver; Schwarz, Juliane P.; Ward, Chris; Monsefi, Naser; Rodrguez, Javier; Garcia-Munoz, Amaya; Birtwistle, Marc; Bienvenut, Willy; Anderson, Kurt I.

2013-01-01

416

Extracellular signal-regulated kinase regulates RhoA activation and tumor cell plasticity by inhibiting guanine exchange factor H1 activity.  

PubMed

In certain Ras mutant cell lines, the inhibition of extracellular signal-regulated kinase (ERK) signaling increases RhoA activity and inhibits cell motility, which was attributed to a decrease in Fra-1 levels. Here we report a Fra-1-independent augmentation of RhoA signaling during short-term inhibition of ERK signaling. Using mass spectrometry-based proteomics, we identified guanine exchange factor H1 (GEF-H1) as mediating this effect. ERK binds to the Rho exchange factor GEF-H1 and phosphorylates it on S959, causing inhibition of GEF-H1 activity and a consequent decrease in RhoA activity. Knockdown experiments and expression of a nonphosphorylatable S959A GEF-H1 mutant showed that this site is crucial in regulating cell motility and invasiveness. Thus, we identified GEF-H1 as a critical ERK effector that regulates motility, cell morphology, and invasiveness. PMID:24043311

von Thun, Anne; Preisinger, Christian; Rath, Oliver; Schwarz, Juliane P; Ward, Chris; Monsefi, Naser; Rodrguez, Javier; Garcia-Munoz, Amaya; Birtwistle, Marc; Bienvenut, Willy; Anderson, Kurt I; Kolch, Walter; von Kriegsheim, Alex

2013-11-01

417

Two cases of functional focal retrograde amnesia with impairment of object use.  

PubMed

We report on two patients, TH and KN, with focal retrograde amnesia (FRA). Their memory loss regarding life events extended to their whole lives, whereas they could acquire and retain new information. They also showed prominent deficits in production and comprehension of common words. In addition, at least in the testing situation, they were impaired in their recognition and use of familiar objects. Although both cases of FRA followed an episode that can cause brain pathology, MRI revealed no structural abnormality in either patient. Stressful situations preceding the onset were evident in KN, but not in TH. We discuss their impairments of object knowledge from a neuropsychological perspective, and we interpret the etiology of their condition as a functional rather than a psychogenic amnesia. PMID:12465671

Nakamura, Hikaru; Kunori, Yoko; Mori, Kayoko; Nakaaki, Shutaro; Yoshida, Shinichi; Hamanaka, Toshihiko

2002-09-01

418

Extralunar materials in cone-crater soil 14141.  

NASA Technical Reports Server (NTRS)

Radiochemical neutron activation analysis has been used to determine Ni, Zn, Ga, Ge, Cd, In, Ir, and Au in duplicate samples of lunar soil 14141 and in one additional replicate each of soils 14163 and 14259. The concentrations of extralunar trace elements Ni, Ge, Ir, and Au in 14141 and 14163 are, respectively, about 69 and 82% as high as those in 14259. Although most of the mass of 14141 appears to be ejecta from Cone Crater, a sizable contamination by mature Fra Mauro soil such as 14259 is also present. The siderophilic-element concentrations of the subregolith Fra Mauro materials are estimated to be 25 plus or minus 25% of those observed in 14259.

Wasson, J. T.; Chou, C.-L.; Bild, R. W.; Baedecker, P. A.

1973-01-01

419

Participation in the Apollo passive seismic experiment  

NASA Technical Reports Server (NTRS)

Computer programs which were written to read digital tapes containing lunar seismic data were studied. Interpreting very early parts of the lunar seismogram as seismic body-wave phases enabled the determination of the structure of the outer part of the moon in the Fra Mauro region. The crust in the Fra Mauro region is 60 to 65 km-thick, overlaying a high velocity mantle. The crust is further divided into an upper part, 25 km thick, apparently made of material similar to the surficial basalts, and a lower part of seemingly different composition, possibly an anorthositic gabbro. The generation of the exceedingly long reverberating wave-train observed in lunar seismogram was also studied. This is believed to be due to an intense scattering layer with very high quality coefficient overlying a more homogeneous elastic medium. Titles and abstracts of related published papers are included.

Press, F.; Toksoez, M. N.; Dainty, A.

1972-01-01

420

Genetic and biophysical characterization of GCN4 leucine zipper mutants and peptides  

E-print Network

fulfillment of the requirements for the degree of MASTER OF SCIENCE Approved as to style and content by: James C, Hu (Chair of Committee) , i IGrx Linda A. +amino (Member) J. Martin Scholt (Member+ Lori R. Bernstein (Member) Gr ory . Rei art (H... Fra-2 dFRA r-Jca J B J D dHIA G(. N4 I ILI 4 YAPI PAPI bXBP I I'GA I b TGA Ic TAF-I HBPI a HBPIb EmBP-I i} A' H A R (} A Q /& Q R Q X R R E R R R t R S R k K V V V L V V V V V V V V V V I E 0:7 S F L'T A...

Hadziselimovic, Arina

2001-01-01

421

Genesis of highland basalt breccias - A view from 66095  

NASA Technical Reports Server (NTRS)

Electron microprobe and defocused beam analyses of the lunar highland breccia sample 66095 show it consists of a fine-grained subophitic matrix containing a variety of mineral and lithic clasts, such as intergranular and cataclastic ANT, shocked and unshocked plagioclase, and basalts. Consideration of the chemistries of both matrix and clasts provides a basis for a qualitative three-component mixing model consisting of an ANT plutonic complex, a Fra Mauro basalt, and minor meteoric material.

Garrison, J. R., Jr.; Taylor, L. A.

1980-01-01

422

Review of severe deformation recommended practice through analyses comparison of two cab car end frame designs  

Microsoft Academic Search

Non-linear large deformation analyses have been conducted to evaluate the performance of the cab car corner and collision posts of the Federal Railroad Administration's (FRA) sponsored state-of-the-art (SOA) end frame design and the Bombardier M7 design under quasi-static and dynamic test conditions. Pre-test analysis predictions of the dynamic performance of the SOA corner post closely match test measurements. A similar

Eloy Martinez; D. Tyrell; John Zolock

2005-01-01

423

ULTIMO CONCERTO STAGIONE SINFONICA 2010/2011 gioved 30 Giugno 2011 ore 21.00  

E-print Network

'Estate in sol minore Concerto n. 3 L'Autunno in fa maggiore - Concerto n. 4 L'Inverno in fa minore A. PIAZZOLLA, alchimia perfetta di stati d'animo e forze della natura. Le Quattro Stagioni (Porteñe) di Piazzolla. Con le sue Quattro Stagioni (1960-1975), Piazzolla ha disegnato uno dei più alti modelli d'incontro fra tango

De Cindio, Fiorella

424

Ontology-Driven Health Information Systems Architectures  

Microsoft Academic Search

Abstract.Following an architecture vision such as the Generic Component Model (GCM) architecture fra mework, health information systems for supporting personalized,care have,to be based,on a component-oriented architecture. Representing concepts and their interrelations, the GCM perspectives syste m architecture, domains, and development process can be described bythe domains ontologies. The paper introduces ontology principles, ontology references to the GCM as w ell

Bernd Blobel; Frank Oemig

2009-01-01

425

CNRM/GAME, UMR 3589 Proposition de Stage M2 ou de fin d'Etude pour 2014  

E-print Network

CNRM/GAME, UMR 3589 Proposition de Stage M2 ou de fin d'Etude pour 2014 Nom du laboratoire (et n° de l'unité) dans lequel se déroulera le stage : Météo-France, CEN, CNRM-GAME, UMR 3589 Titre du sujet neige humide regelée ou de la neige fraîche. #12;CNRM/GAME, UMR 3589 Ce stage requiert de fortes

Ribes, Aurélien

426

Role of Fraction 1 Antigen of Yersinia pestis in Inhibition of Phagocytosis  

Microsoft Academic Search

Yersinia pestis, the causative agent of plague, expresses a capsule-like antigen, fraction 1 (F1), at 37C. F1 is encoded by the caf1 gene located on the large 100-kb pFra plasmid, which is unique to Y. pestis. F1 is a surface polymer composed of a protein subunit, Caf1, with a molecular mass of 15.5 kDa. The secretion and assembly of F1

Yidong Du; Roland Rosqvist; ke Forsberg

2002-01-01

427

Hazardous-materials car placement in a train consist. Volume 2. Appendices. Final report, 18 Feb17 Nov 88  

Microsoft Academic Search

Appendices, Volume II consist of Appendix A. Form FRA F6180-54 (12-74) Rail Equipment Accident\\/Incident Report; Appendix B. Data Related to Derailment Analysis; Appendix C. Review of Selected Railroad Accidents Involving Multiple Hazardous Materials; Appendix D. U.S. Department of Transportation Hazmat Car Placement Regulations; Appendix E. Canadian Transport Commission Hazmat Car Placement Regulations; Appendix F. Hazardous Materials Definitions; Appendix G. Table

R. E. Thompson; E. R. Zamejc; D. R. Ahlbeck

1992-01-01

428

Il ruolo di Guglielmo Marconi  

Microsoft Academic Search

\\u000a Marconi, come risulta dai verbali, non era molto assiduo alle riunioni del Direttorio del CNR. In quel periodo, nonostante\\u000a il manifestarsi dei primi sintomi dellamalattia cardiaca che lavrebbe condotto alla morte nel 1937, continuava a dividersi\\u000a fra numerosi impegni: la Reale Accademia dItalia di cui era stato nominato da poco presidente, la costruzione della prima\\u000a stazione radio del Vaticano, gli

Franco Foresta Martin; Geppi Calcara

429

Om plutoniums giftighed Inden for de seneste mneder har sagen om  

E-print Network

1 Om plutoniums giftighed Inden for de seneste måneder har sagen om Thule-arbejderne nået sit plutonium-239, der blev spredt på isen ved flystyrtet. Plutonium og kræftsygdomme Plutonium er et stof, man tungt opløselig form. Da plutonium kun udsender alfa-stråling er det - set fra et helsefysisk synspunkt

430

Plutonium-244 fission tracks - Evidence in a lunar rock 3.95 billion years old.  

NASA Technical Reports Server (NTRS)

Tracks attributed to the spontaneous fission of plutonium-244 and of uranium-238 were detected in a large whitlockite crystal in the lunar breccia 14321 from the Fra Mauro formation. For a track-retention age of 3.95 b.y., the number of plutonium tracks relative to the number of uranium tracks is 0.51 plus or minus 0.15, provided that the rock was not heavily neutron-irradiated 3.95 b.y. ago.

Hutcheon, I. D.; Price, P. B.

1972-01-01

431

Stimulation of astrocyte-enriched culture with C2 ceramide increases proenkephalin mRNA: involvement of cAMP-response element binding protein and mitogen activated protein kinases  

Microsoft Academic Search

In rat astrocyte-enriched culture, C2 ceramide dose- and time-dependently increased proenkephalin (proENK) mRNA; the significant increase began at 6 h after 30 ?M C2 ceramide treatment (about 13-fold) and at 12 h after treatment (about 21-fold). In addition, C2 ceramide also increased AP-1 proteins, such as Fra-1, c-Jun, JunB and JunD, and phosphorylation of CREB. The blocking of protein synthesis

Je-Seong Won; Mi-Ran Choi; Hong-Won Suh

2001-01-01

432

The FHIT Gene, Spanning the Chromosome 3p14.2 Fragile Site and Renal CarcinomaAssociated t(3;8) Breakpoint, Is Abnormal in Digestive Tract Cancers  

Microsoft Academic Search

A 200300 kb region of chromosome 3p14.2, including the fragile site locus FRA3B, is homozygously deleted in multiple tumor-derived cell lines. Exon amplification from cosmids covering this deleted region allowed identification of the human FHIT gene, a member of the histidine triad gene family, which encodes a protein with 69% similarity to an S. pombe enzyme, diadenosine 5?, 5??? P1,

Masataka Ohta; Hiroshi Inoue; Maria Grazia Cotticelli; Kumar Kastury; Raffaele Baffa; Juan Palazzo; Zurab Siprashvili; Masaki Mori; Peter McCue; Teresa Druck; Carlo M Croce; Kay Huebner

1996-01-01

433

The rotavirus nonstructural protein 4 (NSP4) interacts with both the N- and C- termini of caveolin-1  

E-print Network

and localized the NSP4 binding domains to caveolin-1 residues 2-22 and 161-178. These data support the hypothesis that caveolin-1 mediates NSP4 signaling and/or intracellular trafficking. iv TABLE OF CONTENTS Page CHAPTER I INTRODUCTION... caveolae suffices to induce formation of caveolar vesicles (Fra et al., 1995). Caveolin-1 monomers form stable oligomers via attachment at the oligomerization domain (aa 60-100) (Figure 1). These oligomers, found in 200, 400, and 600 kilodalton (k...

Mir, Kiran D

2006-08-16

434

Carbon emissions from tropical deforestation and regrowth based on satellite observations for the 1980s and 1990s  

Microsoft Academic Search

regions, especially for the 1980s. However, our results indicate that the net rate of tropical forest clearing increased '10% from the 1980s to 1990s, most notably in southeast Asia, in contrast to an 11% reduction reported by the FRA. We estimate net mean annual carbon fluxes from tropical deforestation and regrowth to average 0.6 (0.3- 0.8) and 0.9 (0.5-1.4) petagrams

Ruth S. DeFries; Richard A. Houghton; Matthew C. Hansen; Christopher B. Field; D. Skole; John Townshend

2002-01-01

435

A Quantitative Study of Mobility Impact for Real-Time Services on a Wi-Fi Multi-hop Network  

Microsoft Academic Search

In this paper, we analyze the performance of mobile real time services in a large-scale IEEE 802.11 multi-hop network. We present our field measurements with discussion of performance bottlenecks for VoIP services under mobile scenarios. We utilized our test bed which is located in Nebraska and supported by the University of Nebraska-Lincoln (UNL), US Federal Railroads Administrations (FRA), and major

Ting Zhou; Hamid Sharif; Michael Hempel; Puttipong Mahasukhon; Wei Wang; Song Ci

2008-01-01

436

On the self-similar nature of Ethernet traffic (extended version)  

Microsoft Academic Search

Abstrac(-We demonstrate that Ethernet LAN traffic is statis- tically se~-simi\\/ar, that none of the commonly used traffic models is able to capture this fra((al-like behavior, that such behavior has serious implications for the design, control, and analysis of high-speed, cell-based networks, and that aggregating streams of such traffic typically intensifies the self-similarity (\\

Will E. Leland; Murad S. Taqqu; Walter Willinger; Daniel V. Wilson

1994-01-01

437

QUANDO IL GIOCO DIVENTA UN PROBLEMA Il gioco d'azzardo patologico. Criteri e strategie d'intervento  

Microsoft Academic Search

1) L'uomo, il gioco e l'azzardo L'attivit ludica pu essere indagata a partire da molteplici prospettive: storico-letteraria, socio- antropologica, psicoanalitica, pedagogica, linguistica, etologica, sperimentale e, pi recentemente, clinica. Il gioco, infatti, assume significati estremamente diversi e anche lontani fra s, accomunandoli in una sovradimensione unificante. La stessa parola gioco, in italiano e ancor pi nel corrispettivo francese jeu, inglese play

Michele G. Sforza; Stefano Oliva

438

Norwegian Information Security Conference Norsk Informasjonssikkerhetskonferanse  

E-print Network

-stiftelsen og Tapir Akademisk Forlag, 2010 ISBN 978-82-519-2705-5 Det må ikke kopieres fra denne boka ut over University College Tapir Akademisk Forlag har som målsetting å bidra til å utvikle gode læremidler og alle utgivelsen: Lasse.Postmyr@tapirforlag.no Tapir Akademisk Forlag 7005 TRONDHEIM Tlf.: 73 59 32 10 Faks: 73 59

Paris-Sud XI, Université de

439

Amoros sekretuki dena La comparaison entre cette posie et la prcdente Ezkonduien koplak (Lapurdum  

E-print Network

'intensité de l'amour qui frappe celui qui n'est plus lui-même puisque le coeur, centre artxibo-00084558,version ezin iretsi, autant dire, selon l'expression commune, qu'il vit d'amour et d'eau fraîche. Mais cet amour qu'il voue à la gente dame est-il partagé ? C'est bien la question essentielle et non résolue, qui

Boyer, Edmond

440

Energy for the future with Ris from nuclear power to sustainable energy Ris NatioNal laboRatoRy foR sustaiNable eNeRgy  

E-print Network

Energy for the future ­ with Risø from nuclear power to sustainable energy Risø NatioNal laboRatoRy foR sustaiNable eNeRgy edited by MoRteN JastRup #12;Energy for the future #12;Energy for the future ­ with Risø from nuclear power to sustainable energy Translated from 'Energi til fremtiden ­ med Risø fra

441

Identification of the genes affecting the regulation of riboflavin synthesis in the flavinogenic yeast Pichia guilliermondii using insertion mutagenesis.  

PubMed

Pichia guilliermondii is a representative of a group of so-called flavinogenic yeast species that overproduce riboflavin (vitamin B(2)) in response to iron limitation. Using insertion mutagenesis, we isolated P. guilliermondii mutants overproducing riboflavin. Analysis of nucleotide sequence of recombination sites revealed that insertion cassettes integrated into the genome disrupting P. guilliermondii genes similar to the VMA1 gene of Ashbya gossypii and Saccharomyces cerevisiae and FES1 and FRA1 genes of S. cerevisiae. The constructed P. guilliermondii?vma1-17 mutant possessed five- to sevenfold elevated riboflavin production and twofold decreased iron cell content as compared with the parental strain. Pichia guilliermondii?fra1-45 mutant accumulated 1.8-2.2-fold more iron in the cells and produced five- to sevenfold more riboflavin as compared with the parental strain. Both ?vma1-17 and ?fes1-77 knockout strains could not grow at 37 C in contrast to the wild-type strain and the ?fra1-45 mutant. Increased riboflavin production by the wild-type strain was observed at 37 C. Although the ?fes1-77 mutant did not overproduce riboflavin, it showed partial complementation when crossed with previously isolated P. guilliermondii riboflavin-overproducing mutant rib80-22. Complementation analysis revealed that ?vma1-17 and ?fra1-45 mutants are distinct from previously reported riboflavin-producing mutants hit1-1, rib80-22 and rib81-31 of this yeast. PMID:21261808

Boretsky, Yuriy R; Pynyaha, Yuriy V; Boretsky, Volodymyr Y; Fedorovych, Dariya V; Fayura, Lyubov R; Protchenko, Olha; Philpott, Caroline C; Sibirny, Andriy A

2011-05-01

442

JOURNAL DE PHYSIQUE IV Colloque C3,supplkment au Journal de Physique 11,Volume 3, aodt 1993  

E-print Network

FraFes with high coefficients of thermal expansion (CTEs7.8-8.6~10 K ) had no cracks. Residual stresses in the Ti with a thermal expansion coefficient of 8.6~10 K also had compressive stresses increased with increasing Tic mole on the the same substrate (CTE 8.6x10-' K-') were measured to be compressive and about 475 MPa. Stresses

Paris-Sud XI, Université de

443

INVITATION: PRAKTISK TEMADAG OM INDHENTNING AF BIO-  

E-print Network

INVITATION: PRAKTISK TEMADAG OM INDHENTNING AF BIO- MASSE FRA LAVBUNDSOMR?DE TIL BIOGAS 24 lavbundsområdet til biogas været stigende de senere år. Der sker en spændende teknologisk udvikling indenfor som har draget erfaringer med høst og anvendelse af enggræs til biogas, og se udstyr til slåning af

444

Further delineation of X-linked mental retardation  

Microsoft Academic Search

Chromosomal, clinical, and psychological data are presented on members of six families with X-linked mental retardation. Affected males in three of these families express the fra(X)(q28) marker, while the retarded males in the other three do not. Similar variable physical and psychological charateristics, such as lop ears, large testes, and perseverative speech, are present in affected males in all six

D. S. Herbst; H. G. Dunn; F. J. Dill; D. K. Kalousek; L. W. Krywaniuk

1981-01-01

445

8 RIS N Y T 2/00 Riss kemikere har kon-  

E-print Network

8 RIS? N Y T 2/00 Risøs kemikere har kon- strueret en sensor, der kan genkende ephedrin, som står fundet et stof, der pas- ser perfekt sammen med ephedrin. Dermed har de udviklet en sensor, der kan afsløre ephedrin i en blodprøve. Ephedrin er i sig selv interessant. Stoffet, der udvindes fra planter

446

Specific interactions between Smad proteins and AP-1 components determine TGF?-induced breast cancer cell invasion.  

PubMed

Deregulation of the transforming growth factor ? (TGF?) signal transduction cascade is functionally linked to cancer. In early phases, TGF? acts as a tumor suppressor by inhibiting tumor cell proliferation, whereas in late phases, it can act as a tumor promoter by stimulating tumor cell invasion and metastasis. Smad transcriptional effectors mediate TGF? responses, but relatively little is known about the Smad-containing complexes that are important for epithelial-mesenchymal transition and invasion. In this study, we have tested the hypothesis that specific members of the AP-1 transcription factor family determine TGF? signaling specificity in breast cancer cell invasion. Using a 3D model of collagen-embedded spheroids of MCF10A-MII premalignant human breast cancer cells, we identified the AP-1 transcription factor components c-Jun, JunB, c-Fos and Fra1 as essential factors for TGF?-induced invasion and found that various mesenchymal and invasion-associated TGF?-induced genes are co-regulated by these proteins. In situ proximity ligation assays showed that TGF? signaling not only induces complexes between Smad3 and Smad4 in the nucleus but also complexes between Smad2/3 and Fra1, whereas complexes between Smad3, c-Jun and JunB could already be detected before TGF? stimulation. Finally, chromatin immunoprecipitations showed that c-Jun, JunB and Fra1, but not c-Fos, are required for TGF?-induced binding of Smad2/3 to the mmp-10 and pai-1 promoters. Together these results suggest that in particular formation of Smad2/3-Fra1 complexes may reflect activation of the Smad/AP-1-dependent TGF?-induced invasion program. PMID:22926518

Sundqvist, A; Zieba, A; Vasilaki, E; Herrera Hidalgo, C; Sderberg, O; Koinuma, D; Miyazono, K; Heldin, C-H; Landegren, U; Ten Dijke, P; van Dam, H

2013-08-01

447

Desynchronization and internal dissociation in aircrew  

Microsoft Academic Search

Continuous records of sleep, sleepiness, urine samples and subjective fatigue ratings were obtained from and continuous monitoring of their temperature and electrocardiogram (ECG) was carried out on 12 B747 cockpit crewmembers during a base-line period of 36h, 3 days of operating regular passenger flights between Frankfurt (FRA) and San Francisco (SFO) and 44h after their return to Germany. This paper

A. SAMEL; H. M. WEGMANN

1987-01-01

448

Aircrew fatigue in long-Haul operations  

Microsoft Academic Search

The studies were conducted on the transmeridian routes Dsseldorf (DUS)-Atlanta (ATL) and Hamburg (HAM)-Los Angeles (LAX), and on the north-south route Frankfurt (FRA)-Mahe (SEZ). Scheduled flight duration was between 8:50 hours (ATL-DUS) and 11:50 hours (HAM-LAX). In total, 25 rotations (50 flights) have been investigated by pre-, in- and post-flight data collection of sleep, taskload, fatigue and stress by electroencephalogram

Alexander Samel; Hans-Martin Wegmann; Martin Vejvoda

1997-01-01

449

Den prkeynesianske Malthus  

Microsoft Academic Search

Fra den konomiske teorihistorie er Thomas Malthus kendt, bermt og mske ogs berygtet for sin pessimistiske befolkningslre. Udover med dette teori-element at levere argumentationen hos de klassiske konomer for, at arbejds-kraften i normale situationer ndvendigvis m blive aflnnet p et eksistensmi-nimum, indeholder hans forfatterskab dog ogs elementer, der med nutidige j-ne ser helt moderne ud. I nrvrende papir belyses det

Finn Olesen

2004-01-01

450

Visual monitoring of railroad grade crossing  

Microsoft Academic Search

There are approximately 261,000 rail crossings in the United States according to the studies by the National Highway Traffic Safety Administration (NHTSA) and Federal Railroad Administration (FRA). From 1993 to 1998, there were over 25,000 highway-rail crossing incidents involving motor vehicles - averaging 4,167 incidents a year. In this paper, we present a real-time computer vision system for the monitoring

Y Zhai; K Shafique; M Shah

2004-01-01

451

Retinoic Acid Receptors Inhibit AP1 Activation by Regulating Extracellular Signal-Regulated Kinase and CBP Recruitment to an AP1Responsive Promoter  

Microsoft Academic Search

kinase (MAPK)-extracellular signal-regulated kinase (ERK) pathway (MAPKERK) is characterized, in intact cells, by a switch from a fra2-junD dimer to a junD-fosB dimer loading on its promoter and by simultaneous recruitment of ERKs, CREB-binding protein (CBP), and RNA polymerase II. All-trans-retinoic acid (atRA) receptor (RAR) was tethered constitutively to the AP1 promoter. AP1 transrepression by retinoic acid was concomitant to

Madjid Benkoussa; Cline Brand; Marie-Hlne Delmotte; Pierre Formstecher; Philippe Lefebvre

2002-01-01

452

The Requirement for and Changing Composition of the Activating Protein-1 Transcription Factor during Differentiation of Human Leukemia HL60 Cells Induced by 1,25-Dihydroxyvitamin D3  

PubMed Central

The activating protein-1 (AP-1) transcription factor complex is a heterogeneous entity, composed in mammalian cells of dimers chosen from a group of at least eight proteins belonging to three families: jun, fos, and activating transcription factor (ATF). The AP-1 complexes participate in diverse biological processes that include cell proliferation, survival, and differentiation. These seemingly contrasting functions have been attributed to the intensity and duration of the signals provided by AP-1, but the biological consequences of changing composition of the AP-1 complex have not been fully explored. Here, we show that functional AP-1 is required for 1,25-dihydroxyvitamin D3 (1,25D)-induced monocytic differentiation, and that the composition of the AP-1 protein complex that binds TRE, its cognate DNA element, changes as cells differentiate. In HL60 cells in an early stage of differentiation, the principal AP-1 components detected by gel shift analysis include c-jun, ATF-2, fos-B, fra-1, and fra-2. In cells with a more established monocytic phenotype, the demonstrable AP-1 components are c-jun, ATF-2, jun-B, and fos-B. Following the addition of 1 nmol/L of 1,25D, the cellular content of each of these four proteins markedly increased in a sustained manner, whereas the increases in c-fos, fra-1, fra-2, and jun-D were minimal, if any. Small increases in mRNA levels encoding all AP-1 component proteins, except c-fos, were also noted. These findings provide a basis for the previously found participation of the c-Jun N-terminal kinase pathway in 1,25D-induced differentiation of myeloid leukemia cells, and direct attention to jun-B and fos-B as new cellular therapeutic targets, that may promote replicative quiescence associated with differentiation of malignant cells. PMID:16618766

Wang, Xuening; Studzinski, George P.

2010-01-01

453

Hvad er det kommercielle potentiale i din forskning?  

E-print Network

: Technology Transfer Office 8942 6885. · Deadline 30. juni 2011 Prøv kræfter med Silicon Valley's innovative med base hos og hjælp fra det danske Innovationscenter i hjertet af Silicon Valley, kast dig ud på det. Silicon Valley er ikke bare et af de største innovative miljøer i verden, men også et af de mest dynamiske

454

Geochemistry of the Lunar Highlands  

Microsoft Academic Search

The principal rock types in the highlands are highland basalt (gabbroic anorthosite) with 28% Al2O3 and low K Fra Mauro basalt with 18% Al2O3. The chemistry of the highland soils and breccias can be represented by simple mixing models involving these rock types as major constituents. The mixing occurred during the intense highland cratering. Layering observed at the Apennine Front

Stuart Ross Taylor

1973-01-01

455

The PIAS-Like Protein Zimp10 Is Essential for Embryonic Viability and Proper Vascular Development?  

PubMed Central

Members of the PIAS (for protein inhibitor of activated STAT) family play critical roles in modulating the activity of a variety of transcriptional regulators. Zimp10, a novel PIAS-like protein, is a transcriptional coregulator and may be involved in the modification of chromatin through interactions with the SWI/SNF chromatin-remodeling complexes. Here, we investigate the biological role of Zimp10 in zimp10-deficient mice. Homozygosity for the Zimp10-targeted allele resulted in developmental arrest at approximately embryonic day 10.5. Analysis of knockout embryos revealed severe defects in the reorganization of the yolk sac vascular plexus. No significant abnormality in hematopoietic potential was observed in zimp10 null mice. Microarray and quantified reverse transcription-PCR analyses showed that the expression of the Fos family member Fra-1, which is involved in extraembryonic vascular development, was reduced in yolk sac tissues of zimp10 null embryos. Using fra-1 promoter/reporter constructs, we further demonstrate the regulatory role of Zimp10 on the transcription of Fra-1. This study provides evidence to demonstrate a crucial role for Zimp10 in vasculogenesis. PMID:17967885

Beliakoff, Jason; Lee, Jane; Ueno, Hiroo; Aiyer, Aparna; Weissman, Irving L.; Barsh, Gregory S.; Cardiff, Robert D.; Sun, Zijie

2008-01-01

456

Neuropsychological profiles of three sisters homozygous for the fragile X premutation  

SciTech Connect

Fragile X syndrome (fraX) is associated with an amplification of a CGG repeat within the fraX mental retardation (FMR-1) gene. We describe an exceptional family in which 3 adult sisters are homozygous for the FMR-1 premutation. Each sister inherited 2 premutation alleles (ca. 80 CGG repeats) from their biologically unrelated parents. The 3 sisters were administered measures of executive function, visual spatial, memory, and verbal skills. Deficiencies in the first 2 of these domains have been reported among females with the full mutation. The sisters` performances were compared with available normative data and with published group means for females affected by fraX. These women did not appear to have verbal or memory difficulties. None of the women demonstrated a global executive function deficit, and none had global deficits in spatial ability. The profiles of these sisters are consistent with reports that the fragile X premutation does not affect cognitive performance. 31 refs., 1 fig., 4 tabs.

Mazzocco, M.M.M. [Johns Hopkins School of Medicine, Baltimore, MD (United States)] [Johns Hopkins School of Medicine, Baltimore, MD (United States); Holden, J.J.A. [Ongwanada Resource Centre, Kingston, Ontario (Canada)] [Ongwanada Resource Centre, Kingston, Ontario (Canada)

1996-08-09

457

Transient global amnesia and functional retrograde amnesia: contrasting examples of episodic memory loss.  

PubMed

We studied 11 patients with transient global amnesia (TGA) and ten patients with functional retrograde amnesia (FRA). Patients with TGA had a uniform clinical picture: a severe, relatively isolated amnesic syndrome that started suddenly, persisted for 4-12 h, and then gradually improved to essentially normal over the next 12-24 h. During the episode, the patients had severe anterograde amnesia for verbal and non-verbal material and retrograde amnesia that typically covered at least two decades. Thirty hours to 42 days after the episode, the patients had recovered completely and performed normally on tests of anterograde and retrograde amnesia. By contrast, patients with FRA had a sudden onset of memory problems that were characterized by severe retrograde amnesia without associated anterograde amnesia and with a clinical presentation that otherwise varied considerably. The episodes persisted from several weeks to more than two years, and some of the patients had not recovered at the time of our last contact with them. The uniform clinical picture of TGA and the variable clinical picture of FRA presumably reflect their respective neurologic ('organic') and psychogenic ('non-organic') aetiologies. PMID:9415927

Kritchevsky, M; Zouzounis, J; Squire, L R

1997-11-29

458

Molecular fragil X screening in normal populations  

SciTech Connect

In December, 1993, we initiated a pilot project in which DNA fragile X (fraX) testing was offered during routine prenatal or genetic counseling to all pregnant women seen at the Genetics & IVF Institute, most of whom were referred for the indication of advanced maternal age. A brochure on fragile X syndrome was sent to each patient prior to her appointment and was reviewed by a counselor or physician during the counseling session. As of June 1995, 3,345 patients were offered testing; 474 women with no identified family history of mental retardation or learning disability and 214 women with a positive family history accepted the test on a self-pay basis. The second population screened was 271 potential donors in our anonymous egg donor program. DNA from blood was tested by Southern blot using EcoRI/EagI and StB12.3. If an expansion was detected, CGG repeat number was determined by PCR-based analysis. Among the 474 patients with unremarkable family histories, three fraX carriers were identified (repeat sizes = 60+), whereas none were found in the 214 patients with a positive family history. Among the potential egg donors, two high borderline patients were identified (repeat sizes = between 50 and 59). Our ongoing study indicates that screening of pregnant or preconceptual populations for fraX carrier status using DNA testing is accepted by many patients and is an important addition to current medical practice. 12 refs., 1 tab.

Spence, W.C.; Black, S.H.; Fallon, L. [Genetics & IVF Inst., Fairfax, VA (United States)] [and others] [Genetics & IVF Inst., Fairfax, VA (United States); and others

1996-07-12

459

Arachidonic acid-dependent gene regulation during preadipocyte differentiation controls adipocyte potential[S  

PubMed Central

Arachidonic acid (AA) is a major PUFA that has been implicated in the regulation of adipogenesis. We examined the effect of a short exposure to AA at different stages of 3T3-L1 adipocyte differentiation. AA caused the upregulation of fatty acid binding protein 4 (FABP4/aP2) following 24 h of differentiation. This was mediated by the prostaglandin F2? (PGF2?), as inhibition of cyclooxygenases or PGF2? receptor signaling counteracted the AA-mediated aP2 induction. In addition, calcium, protein kinase C, and ERK are all key elements of the pathway through which AA induces the expression of aP2. We also show that treatment with AA during the first 24 h of differentiation upregulates the expression of the transcription factor Fos-related antigen 1 (Fra-1) via the same pathway. Finally, treatment with AA for 24 h at the beginning of the adipocyte differentiation is sufficient to inhibit the late stages of adipogenesis through a Fra-1-dependent pathway, as Fra-1 knockdown rescued adipogenesis. Our data show that AA is able to program the differentiation potential of preadipocytes by regulating gene expression at the early stages of adipogenesis. PMID:25325755

Nikolopoulou, Evanthia; Papacleovoulou, Georgia; Jean-Alphonse, Frederic; Grimaldi, Giulia; Parker, Malcolm G.; Hanyaloglu, Aylin C.; Christian, Mark

2014-01-01

460

Prediction of mental status in carriers of the fragile X mutation using CGG repeat length.  

PubMed

For genetic counseling in fragile X (fra(X)) families, it is important to know the diagnostic impact of the CGG repeat length in carriers of the fragile X mutation. We have analyzed the CGG repeat length in 106 males and 73 females who had inherited the maternal fra(X) mutation. The sensitivity, specificity, and predictive value of the CGG repeat analyses, as measured on Southern blots of PstI/EcoRI digests, were calculated. In males the sensitivity, specificity and negative predictive value were 99%, 100% and 94%; respectively. In females the specificity (60%) and, consequently, the positive predictive value (82%) was reduced. Therefore, it remains impossible to predict accurately whether a female fetus demonstrating a full mutation will be affected. On the other hand, the negative predictive value of the CGG test in females was 100%. We have no evidence, as yet, that for female carriers with the full mutation, cytogenetic analysis is of additional value to predict the mental status. However, we have observed one mentally retarded fra(X) case with extreme mosaicism in which a typical premutation fragment was the predominant DNA species. Therefore, until more data and better DNA tests are available, we would like to advocate additional cytogenetic investigation if in a fetus a CGG repeat length in the premutation range is found. PMID:7943027

Smits, A; Smeets, D; Hamel, B; Dreesen, J; de Haan, A; van Oost, B

1994-07-15

461

CD44 affects the expression level of FOS?like antigen 1 in cervical cancer tissues.  

PubMed

Cervical carcinoma is the second most prevalent type of malignancy in females worldwide. The crucial etiological factors involved in the development of cervical carcinoma include infection with the papillomavirus, and the structural or functional mutation of oncogenes and tumor suppressor genes. CD44 refers to a multifunctional family of type I transmembrane proteins. These proteins have been implicated in numerous biological processes, including cell adhesion, cell migration and metastasis. The present study examined the differences in the expression levels of ATP-binding cassette sub-family G member 2, CD24, CD44, CD133, cytokeratin (CK) 14 and CK19 between cervical cancer tissues and corresponding normal non-tumor tissues by flow cytometry. Then, the CD44+ or CD44? cells from cervical cancer tissues were sorted for identification and confirmation of differential expression by flow cytometry. The results demonstrated that the expression level of CD44 in cervical cancer tissues was higher than in the corresponding non-tumor normal tissues (t=3.12; P=0.0102). Compared with the CD44? cells, the FOS-like antigen 1 (Fra-1), nestin, nuclear receptor subfamily 4, group A, member 2, OCT4 and p63 genes were highly expressed in CD44+ cells. The fold changes were 3.55, 3.55, 2.46, 2.87 and 2.56, respectively (P<0.05). However, BMI1 polycomb ring finger oncogene, ck5, tumor protein p53 and lactotransferrin genes exhibited low expression levels in CD44+ cells. It was verified by western blot analysis and flow cytometry that Fra-1 was highly expressed in CD44+ cells. Fra-1 was a potential target of miR-19a and miR-19b. The expression of miR-19a and miR-19b was downregulated by ~50% in CD44+ cells compared with CD44? cells. These findings suggested that CD44 dysregulated the activation of the Fra?1 gene. The interaction of Fra-1 and CD44 may therefore be important in cervical carcinoma. PMID:24604526

Xiao, Songshu; Zhou, Yanhong; Jiang, Jianfa; Yuan, Le; Xue, Min

2014-05-01

462

Sleep research in space: expression of immediate early genes in forebrain structures of rats during the nasa neurolab mission (STS-90).  

PubMed

1. Electrophysiological and behavioural observations have shown that changes in the sleep-waking activity occur in astronauts during the space flight. Experiments performed in ground-based experiments have previously shown that the immediate early gene (IEG) c-fos, a marker of neuronal activation, can be used as a molecular correlate of sleep and waking. However, while Fos expression peaks within 2-4 hours after the stimulus and returns to baseline within 6-8 hours, other IEGs as the FRA proteins which are also synthetized soon after their induction, persist in the cell nuclei for longer periods of time, ranging from 1-2 days to weeks. 2. Both Fos and FRA expression were evaluated in several adult albino rats sacrificed at different time points of the space flight, i.e. either at FD2 and FD14, i.e. at launch and about two weeks after launch, respectively, or at R + 1 and R + 13, i.e. at the reentry and about two weeks after landing. The changes in Fos and FRA expression were then compared with those obtained in ground controls. These experiments demonstrate activation of several brain areas which varies during the different phases of the space flight. Due to their different time of persistence, Fos and FRA immunohistochemistry can provide only correlative observations. In particular, FRA expression has been quite helpful to identify the occurrence of short-lasting events such as those related either to stress or to REM-sleep, whose episodes last in the rat only a few min and could hardly be detected by using only Fos expression. 3. Evidence was presented indicating that at FD2 and FD14 Fos-labeled cells were observed in several brain areas in which Fos had been previously identified as being induced by spontaneous or forced waking in ground-based experiments. In contrast to these findings FLT rats sacrificed at R + 1 showed low levels of Fos immunostaining in the cerebral cortex (neocortex) and several forebrain structures such as the hypothalamus and thalamus. Some Fos staining was also present in limbic cortical areas, the septum, and the hippocampus. The main area of the forebrain of FLT rats sacrificed at R + 1, showing an increased expression of Fos, was the central nucleus of the amygdala (CeA) (cf. 127), as well as the noradrenergic locus coeruleus (LC) nucleus (cf. 122). At R + 13 Fos immunostaining was variable among FLT rats. However, none of these rats showed a significant number of Fos-positive cells in CeA. 4. Most of the rats studied for Fos expression were also tested for FRA expression. In particular, a scattered amount of FRA expression occurred at FD14 in different areas of the neocortex and in limbic forebrain regions (such as the cingulate, retrosplenial and entorhinal cortex). It included also the hippocampus, the lateral septum, the caudate/putamen, as well as some hypothalamic regions. At the reentry (R + 1) it was previously shown that a prominent increase in FRA expression occurred in the LC of FLT rats (cf. 122). This finding was associated with an increase in FRA expression which affected not only the nucleus paragigantocellularis lateralis of the medulla, which sends excitatory glutamatergic afferents to the LC (cf. 31 for ref.), but also structures which are known to produce corticotropin-releasing factor (CRF), a neuropeptide which activates the noradrenergic LC neurons during stress. 5. These findings which result from acceleration stress were followed by REMS episodes, which probably occurred after a long period of sleep deprivation following exposure to microgravity. It was previously shown that an increase in Fos and FRA expression occurred at the reentry in some pontine and medullary reticular structures (cf. 128), which are likely to be involved in both the descending (postural atonia) and the ascending manifestations of PS. These findings can be integrated by results of the present experiments showing that at the reentry high levels of FRA expression occurred in the hippocampus and the limbic system, i.e. in structures which are involved in the generalized pattern of EEG desynchroniza

Centini, C; Pompeiano, O

2007-05-01

463

Arsenite suppression of involucrin transcription through AP1 promoter sites in cultured human keratinocytes  

SciTech Connect

While preserving keratinocyte proliferative ability, arsenite suppresses cellular differentiation markers by preventing utilization of AP1 transcriptional response elements. In present experiments, arsenite had a dramatic effect in electrophoretic mobility supershift analysis of proteins binding to an involucrin promoter AP1 response element. Without arsenite treatment, binding of JunB and Fra1 was readily detected in nuclear extracts from preconfluent cultures and was not detected a week after confluence, while c-Fos was detected only after confluence. By contrast, band shift of nuclear extracts from arsenite treated cultures showed only JunB and Fra1 binding in postconfluent as well as preconfluent cultures. Immunoblotting of cell extracts showed that arsenite treatment prevented the loss of Fra1 and the increase in c-Fos proteins that occurred after confluence in untreated cultures. Chromatin immunoprecipitation assays demonstrated substantial reduction of c-Fos and acetylated histone H3 at the proximal and distal AP1 response elements in the involucrin promoter and of coactivator p300 at the proximal element. Alteration of AP1 transcription factors was also examined in response to treatment with four metal containing compounds (chromate, vanadate, hemin, divalent cadmium) that also suppress involucrin transcription. These agents all influenced transcription at AP1 elements in a transcriptional reporter assay, but exhibited less effect than arsenite on binding activity assessed by mobility shift and chromatin immunoprecipitation and displayed variable effects on AP1 protein levels. These findings help trace a mechanism by which transcriptional effects of arsenite become manifest and help rationalize the unique action of arsenite, compared to the other agents, to preserve proliferative ability.

Sinitsyna, Nadezda N.; Reznikova, Tatiana V.; Qin Qin; Song, Hyukhwan; Phillips, Marjorie A. [Department of Environmental Toxicology, University of California, Davis, CA 95616-8588 (United States); Rice, Robert H., E-mail: rhrice@ucdavis.ed [Department of Environmental Toxicology, University of California, Davis, CA 95616-8588 (United States)

2010-03-15

464

Arsenite Suppression of Involucrin Transcription through AP1 Promoter Sites in Cultured Human Keratinocytes  

PubMed Central

While preserving keratinocyte proliferative ability, arsenite suppresses cellular differentiation markers by preventing utilization of AP1 transcriptional response elements. In present experiments, arsenite had a dramatic effect in electrophoretic mobility supershift analysis of proteins binding to an involucrin promoter AP1 response element. Without arsenite treatment, binding of JunB and Fra1 was readily detected in nuclear extracts from preconfluent cultures and was not detected a week after confluence, while c-Fos was detected only after confluence. By contrast, band shift of nuclear extracts from arsenite treated cultures showed only JunB and Fra1 binding in postconfluent as well as preconfluent cultures. Immunoblotting of cell extracts showed that arsenite treatment prevented the loss of Fra1 and the increase in c-Fos proteins that occurred after confluence in untreated cultures. Chromatin immunoprecipitation assays demonstrated substantial reduction of c-Fos and acetylated histone H3 at the proximal and distal AP1 response elements in the involucrin promoter and of coactivator p300 at the proximal element. Alteration of AP1 transcription factors was also examined in response to treatment with four metal containing compounds (chromate, vanadate, hemin, divalent cadmium) that also suppress involucrin transcription. These agents all influenced transcription at AP1 elements in a transcriptional reporter assay, but exhibited less effect than arsenite on binding activity assessed by mobility shift and chromatin immunoprecipitation and displayed variable effects on AP1 protein levels. These findings help trace a mechanism by which transcriptional effects of arsenite become manifest and help rationalize the unique action of arsenite, compared to the other agents, to preserve proliferative ability. PMID:20006635

Sinitsyna, Nadezda N.; Reznikova, Tatiana V.; Qin, Qin; Song, Hyukhwan; Phillips, Marjorie A.; Rice, Robert H.

2009-01-01

465

NGFI-B (Nurr77/Nr4a1) orphan nuclear receptor in rat pinealocytes: circadian expression involves an adrenergic-cyclic AMP mechanism.  

PubMed

NGFI-B (Nur77/Nr4a1) is a member of a nuclear steroid receptor subgroup that includes the related factors Nurr1 (Nr4a2) and NOR-1 (Nr4a3). These proteins do not have recognized ligands and in fact function independently as orphan receptors with transcriptional regulatory activity. In the present study, expression of the NGFI-B gene in the rat pineal gland was found to exhibit a robust circadian rhythm, with elevated levels of NGFI-B mRNA occurring at night. The rhythm of NGFI-B mRNA is translated into a circadian rhythm of NGFI-B protein, which accumulates in the nucleus of pinealocytes. In addition, there is a parallel marked nocturnal increase in pineal DNA binding activity to a NGFI-B response element (NBRE, AAAGGTCA). Pharmacological studies indicate that NGFI-B mRNA and protein levels are elevated via activation of adrenergic receptors. NGFI-B protein levels are also elevated by dibutyryl cyclic AMP, as in other systems. In the pineal gland, regulation of NGFI-B expression also involves the AP-1 protein Fra-2, based on studies with a transgenic Fra-2 knockdown rat, in which pineal NGFI-B expression increases. This set of observations extends the number of pineal genes that are known to be regulated by Fra-2, and also provides the first indication that a member of the NGFI-B group of nuclear receptors is involved in controlling gene expression in the pineal gland. PMID:15525348

Humphries, Ann; Weller, Joan; Klein, David; Baler, Ruben; Carter, David A

2004-11-01

466

Field testing of prototype systems for the non-destructive measurement of the neutral temperature of railroad tracks  

NASA Astrophysics Data System (ADS)

In both high speed and freight rail systems, the modern construction method is Continuous Welded Rail (CWR). The purpose of the CWR method is to eliminate joints in order to reduce the maintenance costs for both the rails and the rolling stock. However the elimination of the joints increases the risk of rail breakage in cold weather and buckling in hot weather. In order to predict the temperature at which the rail will break or buckle, it is critical to have knowledge of the temperature at which the rail is stress free, namely, the Rail Neutral Temperature (Rail-NT).The University of California at San Diego has developed an innovative technique based on non-linear ultrasonic guided waves, under FRA research and development grants for the non-destructive measurement of the neutral temperature of railroad tracks. Through the licensing of this technology from the UCSD and under the sponsorship of the FRA Office of Research and Development, a field deployable prototype system has been developed and recently field tested at cooperating railroad properties. Three prototype systems have been deployed to the Union Pacific (UP), Burlington Northern Santa Fe (BNSF), and AMTRAK railroads for field testing and related data acquisition for a comprehensive evaluation of the system, with respect to both performance and economy of operation. The results from these tests have been very encouraging. Based on the lessons learned from these field tests and the feedback from the railroads, it is planned develop a compact 2nd generation Rail-NT system to foster deployment and furtherance of FRA R&D grant purpose of potential contribution to the agency mission of US railroad safety. In this paper, the results of the field tests with the railroads in summer of 2013 are reported.

Phillips, Robert; Lanza di Scalea, Francesco; Nucera, Claudio; Fateh, Mahmood; Choros, John

2014-03-01

467

A summary of phase analysis on Apollo 14 samples  

NASA Technical Reports Server (NTRS)

The results of an analysis of lunar samples from Apollo 14 are presented. The large number of breccias returned from the Fra Mauro formation show that impact events are an important rock forming mechanism on the moon. Larger rocks as well as micro breccias bear structural resemblance to brecciated chondrites and terrestrial impactites. Many show evidence of repetitious events of break-up and accumulation welding. The surface of the regolith has become thoroughly mixed by this process. Most components however appear locally derived from basalts rich in feldspar and Kreep components, similar to rocks such as 14310.

Fredriksson, K.; Nelen, J.; Noonan, A.; Kraut, F.

1971-01-01

468

NGA Streaming Slideshow: The Adoration of the Magi  

NSDL National Science Digital Library

This streaming audio/slide show is the latest creation from the National Gallery of Art (NGA). The presentation consists of an in-depth examination and explanation of The Adoration of the Magi, the colorful painting by Fra Angelico and Filippo Lippi. The painting is from the early Italian Renaissance and represents the three kings bringing gifts to the Christ Child twelve days after his birth. The slide show is narrated by NGA director, Earl A. Powell, III, and also contains a text transcription.

2002-01-01

469

Hazardous-materials car placement in a train consist. Volume 2. Appendices. Final report, 18 Feb-17 Nov 88  

SciTech Connect

Appendices, Volume II consist of Appendix A. Form FRA F6180-54 (12-74) Rail Equipment Accident/Incident Report; Appendix B. Data Related to Derailment Analysis; Appendix C. Review of Selected Railroad Accidents Involving Multiple Hazardous Materials; Appendix D. U.S. Department of Transportation Hazmat Car Placement Regulations; Appendix E. Canadian Transport Commission Hazmat Car Placement Regulations; Appendix F. Hazardous Materials Definitions; Appendix G. Table of Position in Train Requirements; Appendix H. Chemical Reactivities of Binary Combinations; Appendix I. Results from the Consequence Calculations; Appendix J. Consequence and Risk Rankings of Incompatible Chemical Combinations.

Thompson, R.E.; Zamejc, E.R.; Ahlbeck, D.R.

1992-06-01

470

Predicting violations at gated active highway-railroad grade crossings  

E-print Network

as a Function of FRA Database Exposure 39 Figure 6. Type 1 Violations as a Function of Observed Exposure 39 Figure 7. Type 2 Violations as a Function of Exposure 43 Figure 8. Type 2 Violations as a Function of Warning Time Figure 9. Type 2... . Limitations of the Models . Model Application 61 71 72 VI CONCLUSIONS AND RECOMMENDATIONS . . 73 Conclusions . Recommendations 73 76 REFERENCES . 77 APPENDIX A APPENDIX B 80 83 APPENDIX C 100 VITA 102 LIST OF FIGURES Page Figure 1. Required...

Bean, Jonathan Alan

2012-06-07

471

Cadmium induces phosphorylation and stabilization of c-Fos in HK-2 renal proximal tubular cells  

SciTech Connect

We examined the effects of cadmium chloride (CdCl{sub 2}) exposure on the expression and phosphorylation status of members of the Fos family, components of the activator protein-1 transcription factor, in HK-2 human renal proximal tubular cells. Following the exposure to CdCl{sub 2}, the expression of c-fos, fosB, fra-1, and fra-2 increased markedly, with different magnitudes and time courses. The levels of Fos family proteins (c-Fos, FosB, Fra-1, and Fra-2) also increased in response to CdCl{sub 2} exposure. Although the elevation of c-fos transcripts was transient, c-Fos protein levels increased progressively with lower electrophoretic mobility, suggesting stabilization of c-Fos through post-translational modifications. Consistently, we observed phosphorylation of c-Fos at Ser362 and Ser374 in HK-2 cells treated with CdCl{sub 2}. Phosphorylated forms of mitogen-activated protein kinases (MAPKs)-including extracellular signal-regulated protein kinase (ERK), c-Jun NH{sub 2}-terminal kinase, and p38-increased after CdCl{sub 2} exposure, whereas treatment with the MAPK/ERK kinase inhibitor U0126 and the p38 inhibitor SB203580 suppressed the accumulation and phosphorylation of c-Fos. We mutated Ser362 to alanine (S362A), Ser374 to alanine (S374A), and both residues to alanines (S362A/S374A) to inhibit potential phosphorylation of c-Fos at these sites. S374A or double S362A/S374A mutations reduced c-Fos level markedly, but S362A mutation did not. On the other hand, S362A/S374A mutations induced a more pronounced reduction in c-Fos DNA-binding activity than S374A mutation. These results suggest that while Ser374 phosphorylation seems to play a role in c-Fos stabilization, phosphorylation at two C-terminal serine residues is required for the transcriptional activation of c-Fos in HK-2 cells treated with CdCl{sub 2}.

Iwatsuki, Mamiko; Inageda, Kiyoshi; Matsuoka, Masato, E-mail: matsuoka@research.twmu.ac.jp

2011-03-15

472

Apollo 14 active seismic experiment.  

NASA Technical Reports Server (NTRS)

Explosion seismic refraction data indicate that the lunar near-surface rocks at the Apollo 14 site consist of a regolith 8.5 meters thick and characterized by a compressional wave velocity of 104 meters per second. The regolith is underlain by a layer with a compressional wave velocity of 299 meters per second. The thickness of this layer, which we interpret to be the Fra Mauro Formation, is between 16 and 76 meters. The layer immediately beneath this has a velocity greater than 370 meters per second. We found no evidence of permafrost.

Watkins, J. S.; Kovach, R. L.

1972-01-01

473

Performance Study of a Mobile Multi-hop 802.11a\\/b Railway Network Using Passive Measurement  

Microsoft Academic Search

In this paper, we study the performance of IEEE 802.11a\\/b in a large-scale mobile railway networks and introduce our developed\\u000a passive measurement approach. To provide a comprehensive evaluation, we built an outdoor multi-hop multi-interface railroad\\u000a testbed (UNL-FRA Testbed), which consists of eight access points deployed along 3.5mile of railroad track. We propose a novel\\u000a large-scale passive measurement approach that synchronizes

Ting Zhou; Hamid Sharif; Michael Hempel; Puttipong Mahasukhon; Wei Wang; Hsiao-hwa Chen

2009-01-01

474

Sampling for Bacteria in Wells (Spanish)  

E-print Network

C?mo Tomar Muestras de Pozos (para an?lisis bacteriol?gico) E-126S 11/01 Las muestras de agua para an?lisis bacteriol?gico siempre deben ser tomadas en envases esterilizados. El procedimiento para tomar las muestras de agua es el siguiente: 1.... Obtenga un envase esterilizado del Laboratorio del Departamento de Sanidad o llame a su oficina local del Servicio de Extensi?n. 2. Elija el grifo (llave de paso) de agua fr?a del cual va a tomar la muestra. Qu?tele el oxigenador. No tome muestras de: un...

Lesikar, Bruce J.

2001-11-15

475

Railroad safety program, volume 1  

NASA Technical Reports Server (NTRS)

Since 1981, the Federal Railroad Administration (FRA) has annually prepared a National Inspection Plan (NIP) whose purpose is to summarize regional efforts to improve railroad transportation safety. The research concluded on the following tasks including the problems, conclusions and recommendations associated with these tasks is summarized: (1) the preparation of the 1983 NIP, with recommended procedures for improving future NIPs; (2) the development of an outline for the 1984 NIP, including a methodology for the allocation of inspection resources and other specialized regional activities; (3) the management and development of the 1984 NIP; and (4) the development of an instruction manual to be used in the preparation of future NIPs.

1985-01-01

476

Probabilistic analysis of fires in nuclear plants  

SciTech Connect

The aim of this paper is to describe a multilevel (i.e., staged) probabilistic analysis of fire risks in nuclear plants (as part of a general PRA) which maximizes the benefits of the FRA (fire risk assessment) in a cost effective way. The approach uses several stages of screening, physical modeling of clearly dominant risk contributors, searches for direct (e.g., equipment dependences) and secondary (e.g., fire induced internal flooding) interactions, and relies on lessons learned and available data from and surrogate FRAs. The general methodology is outlined. 6 figs., 10 tabs.

Unione, A.; Teichmann, T.

1985-01-01

477

The History of Cartography in a Nutshell  

E-print Network

Mercator, Fra Mauro, Peutinger Table, C.F. Cassini de Thury Editor?s Note: About five years ago Professor Valerio was asked to prepare a short article on the history of cartography for a multimedia presentation by the Istituto e Museo di... at the equator was conducted by C.M. de La Condamine between 1736 and 1741.) L. A. Brown, The Story of Maps, Dover, New York, 1979, p. 263. 20. Cassini Map. The first great modern geodetic survey undertaken by C.F. Cassini de Thury. A copy from the National...

Valerio, Vladimiro

2008-06-03

478

Argon-40-argon-39 dating of Apollo sample 15555.  

NASA Technical Reports Server (NTRS)

An age of 3.33 (plus or minus 0.05) b.y. was obtained for Apollo 15 sample 15555 by argon-40-argon-39 dating. The age of rock 15555, a basalt from the rim of Hadley Rille, establishes an upper limit to the age of the rille. The basalt flows filling the Hadley Rille section of the Imbrium basin postdate the formation of the basin - as measured by the Apollo 14 samples of the Fra Mauro formation - by at least 500 m.y. Therefore, the mare basalts cannot be simple impact melts but rather must result from some igneous activity on the moon.

Alexander, E. C., Jr.; Davis, P. K.; Lewis, R. S.

1972-01-01

479

Alcuni Richiami Sulla Ionosfera  

Microsoft Academic Search

\\u000a 1. Nell'introduzione a questo corso sulla dinamica dei gas rarefatti il prof. Ferrari ha esposto notevoli caratteristiche\\u000a dell'alta atmosfera. In particolare, ha osservato come ad altezze comprese fra 7080 chilometri e qualche migliaio di chilometri\\u000a esista la cosidetta ionosfera,perch a quelle altezze (sia pure con intensit diversa con l'altezza) i gas che costituiscono\\u000a l'atmosfera sono notevolmente ionizzati, Poich anche il

Dario Graffi

480

On a correlation between surface remanent magnetism and chemistry for the lunar frontside and limbs  

NASA Technical Reports Server (NTRS)

Image-processing techniques applied to orbital data have revealed an inverse correlation between lunar surface remanent magnetism and surface concentrations of Fe and Th on a scale of 250 km and greater. The effect can be understood in terms of the implantation of magnetism early in the history of the moon, coupled with the chronological sequence of highland-mare crustal differentiation. The exception seen at the Fra Mauro region suggests the presence of a source of magnetization sometime within 0.3-0.6 b.y. after formation of the moon.

Metzger, A. E.; Lin, R. P.; Russell, C. T.

1977-01-01

481

An enhanced inheritance algorithm for optimization of multiwavelength fiber Raman amplifier  

NASA Astrophysics Data System (ADS)

Multi-Wavelength Fiber Raman Amplifier (MW-FRA) has become an essential component in DWDM system due to its broad bandwidth, flexibility and excellent performance. This paper is first dedicated to an accurate modeling of the MW-FRA for a propagation equation, which includes fiber loss, Stimulated Raman Scattering (SRS), Rayleigh backscattering, spontaneous emission noise and thermal noise. Then based on the reasonably simplified model it focuses on a numerical calculation with initial pump wavelength and power for the acquisition of on-off gain and flatness of signals, which are taken as feedback information to adjust the corresponding pumps. An inheritance algorithm is applied in the process of such iteration, which moves on until the target gain and flatness are achieved. According to the Raman gain spectrum characteristics, we can improve the algorithm to speed up the calculation and to make it more practically applicable. The design idea here is implemented by using C language. With input target gain and flatness, initial value of signals and pumps, the program can output the optimized results of pump wavelength and power. Besides, the simulation results from employing VPI are demonstrated, which proves the algorithm is effective.

Huang, Jianfei; Wu, Jianxue

2005-01-01

482

Use of flattening filter-free photon beams in treating medulloblastoma: a dosimetric evaluation.  

PubMed

Aim. To evaluate the dosimetric benefits of flattening filter-free (FFF) photon beams in intensity modulated radiation therapy (IMRT) and Rapid Arc (RA) over conventional CSI methods. Methods and Materials. Five patients treated with IMRT using static multileaf collimators (MLC) were randomly selected for this retrospective study. Dynamic MLC IMRT, RA, and conformal therapy (3DCRT) were iterated with the same CT data sets with and without flattening filter photons. Total dose prescribed was 28.80?Gy in 16 fractions. Dosimetric parameters such as D max?, D min?, D mean, V 95%, V 107%, DHI, and CI for PTV and D max?, D mean, V 80%, V 50%, V 30%, and V 10% for OARs were extracted from DVHs. Beam on time (BOT) for various plans was also compared. Results. FFF RA therapy (6F_RA) resulted in highly homogeneous and conformal doses throughout the craniospinal axis. 3DCRT resulted in the highest V 107% (SD) 46.97 28.6, whereas flattening filter (FF) and FFF dynamic IMRT had a minimum V 107%. 6F_RA and 6F_DMLC resulted in lesser doses to thyroid, eyes, esophagus, liver, lungs, and kidneys. Conclusion. FFF IMRT and FFF RA for CSI have definite dosimetric advantages over 3DCRT technique in terms of target coverage and OAR sparing. Use of FFF in IMRT resulted in 50% reduction in BOT, thereby increasing the treatment efficiency. PMID:24579052

Anchineyan, Pichandi; Mani, Ganesh K; Amalraj, Jerrin; Karthik, Balaji; Anbumani, Surega

2014-01-01

483

Evaluation of recombinant antigens of Trypanosoma cruzi to diagnose infection in naturally infected dogs from Chaco region, Argentina.  

PubMed

Dogs are considered the main mammal reservoir of Trypanosoma cruzi in domiciliary environments. Consequently, accurate detection of T. cruzi infection in canine populations is epidemiologically relevant. Here, we analysed the utility of the T. cruzi recombinant antigens FRA, SAPA, CP1, Ag1 and a SAPA/TSSA VI mixture, in an ELISA format. We used a positive control group of sera obtained from 38 dogs from the Chaco region in Argentina with positive homogenate-ELISA reaction, all of them also positive by xenodiagnosis and/or PCR. The negative group included 19 dogs from a nonendemic area. Sensitivity, specificity, area under the curve (AUC) of the receiver operating charactheristic (ROC) curve and Kappa index were obtained to compare the diagnostic efficiency of the tests. The SAPA/TSSA VI had the highest performance, with a sensitivity of 94.7% and an AUC ROC of 0.99 that indicates high accuracy. Among individual antigens, SAPA-ELISA yielded the highest sensitivity (86.8%) and AUC ROC (0.96), whereas FRA-ELISA was the least efficient test (sensitivity = 36.8%; AUC ROC = 0.53). Our results showed that the use of SAPA/TSSA VI in ELISAs could be a useful tool to study dogs naturally infected with T. cruzi in endemic areas. PMID:25201522

Floridia-Yapur, N; Vega-Benedetti, A F; Rumi, M Monje; Ragone, P; Lauthier, J J; Tomasini, N; d'Amato, A M Alberti; Lopez-Quiroga, I; Diosque, P; Marcipar, I; Nasser, J R; Cimino, R O

2014-12-01

484

Safety of high-speed magnetic-levitation transportation systems. Magnetic-field testing of the TR07 maglev vehicle and system. Volume 2. Appendices. Final report Jun 91-Mar 92  

SciTech Connect

The safety of various magnetically levitated (maglev) and high speed rail (HSR) trains proposed for application in the United States is of direct concern to the Federal Railroad Administration (FRA). The characterization of electric and magnetic fields (EMF) emissions, both steady (dc) and produced by alternating currents (ac) at power frequency (50 Hz in Europe and 60 Hz in the U.S.) and other frequencies in the Extreme Low Frequency (ELF) range (3-3000 Hz), and associated public and worker exposures to EMF, are a growing health and safety concern worldwide. As part of a comprehensive safety assessment of the German TransRapid (TR-07) maglev system undertaken by the FRA, with technical support from the DOT/RSPA Volpe National Transportation System Center (VNTSC), magnetic field measurements were performed by Electric Research and Management, Inc. (ERM) at the Transrapid Test Facility (TVE) in Emsland, Germany in August, 1990. Volume II-Appendices catalogs and documents detailed magnetic field data files and their specifics (static fields, spectral waveforms, temporal and spatial information) by location.

Dietrich, F.; Robertson, D.; Steiner, G.

1992-04-01

485

Safety of high-speed magnetic-levitation transportation systems. Magnetic-field testing of the TR07 maglev vehicle and system. Volume 1. Analysis. Final report Jun 91-Mar 92  

SciTech Connect

The safety of various magnetically levitated (maglev) and high speed rail (HSR) trains proposed for application in the United States is of direct concern to the Federal Railroad Administration (FRA). The characterization of electric and magnetic fields (EMF) emissions, both steady (dc) and produced by alternating currents (ac) at power frequency (50 Hz in Europe and 60 Hz in the U.S.) and other frequencies in the Extreme Low Frequency (ELF) range (3-3000 Hz), and associated public and worker exposures to EMF, are a growing health and safety concern worldwide. As part of a comprehensive safety assessment of the German TransRapid (TR-07) maglev system undertaken by the FRA, with technical support from the DOT/RSPA Volpe National Transportation System Center (VNTSC), magnetic field measurements were performed by Electric Research and Management, Inc. (ERM) at the Transrapid Test Facility (TVE) in Emsland, Germany in August, 1990. Volume I-Analysis summarizes the experimental findings and compares results to common home, work, and power lines emissions for selected spectral bands.

Dietrich, F.; Feero, W.E.

1992-04-01

486

Lunar highland melt rocks - Chemistry, petrology and silicate mineralogy  

NASA Technical Reports Server (NTRS)

A selected suite containing several of the largest samples of lunar highland melt rocks includes impact melt specimens (anorthositic gabbro, low-K Fra Mauro) and volcanic specimens (intermediate-K Fra Mauro). Although previous assumptions of LKFM volcanism have fallen into disfavor, no fatal arguments against this hypothesis have been presented, and the evidence of a possibly 'inherited igneous' olivine-plagioclase cosaturation provides cause for keeping a volcanic LKFM hypothesis viable. Comparisons of silicate mineralogy with melt rock compositions provide information on the specimen's composition and cooling history. Plagioclase-rock compositions can be matched to the experimentally determined equilibria for appropriate samples to identify melt rocks with refractory anorthitic clasts. Olivine-rock compositions indicate that melt rock vitrophyres precipitate anomalously Fe-rich olivine; the cause of this anomaly is not immediately evident. The Al-Ti and Ca-Fe-Mg zonation in pyroxene provide information on relative cooling rates of highland melt rocks, but Cr- and Al-content (where Al-rich low-Ca pyroxene cores are preserved in rapidly cooled samples) can be correlated with composition of the host rock.

Vaniman, D. T.; Papike, J. J.

1980-01-01

487

Purification and characterisation of a new antioxidant peptide from chickpea (Cicer arietium L.) protein hydrolysates.  

PubMed

An antioxidant peptide was purified using consecutive chromatographic methods from chickpea protein hydrolysates (CPH). This peptide was designated as Fra.7. It had a molecular weight of 717.37Da, and its amino acid sequence was identified as Asn-Arg-Tyr-His-Glu by an ABI 4700 proteomics analyser. This antioxidant peptide was identified for the first time from food-derived protein hydrolysates. The molar ratio of the five amino acids in the sequence was 1:1:1:1:1. This antioxidant peptide efficiently quenched the free radical sources 1,1-diphenyl-2-pycryl-hydrazyl (DPPH), hydroxyl, and superoxide free radicals. The Cu(2+) and Fe(2+) chelating activities were 76.92% and 63.08% at the peptide concentration of 50?gmL(-1), respectively. Furthermore, the inhibition of the Fra.7 on lipid peroxidation was greater than that of ?-tocopherol. The inhibition ratio of the linoleic acid autooxidation was 88.81% at the eighth day of analysis. PMID:25214325

Zhang, Tao; Li, Yanhong; Miao, Ming; Jiang, Bo

2011-09-01

488

Expression of immediate early genes in the hippocampal formation of the black-capped chickadee (Poecile atricapillus) during a food-hoarding task.  

PubMed

Black-capped chickadees store food in many different locations in their home range and are able to accurately remember these locations. We measured the number of cells immunopositive for three different Immediate Early Gene products (Fra-1, c-Fos and ZENK) to map neuronal activity in the chickadee Hippocampal Formation (HF) during food storing and retrieval. Fra-1-like immunoreactivity is downregulated in the dorsal HF of both storing and retrieving chickadees compared to controls. In retrieving birds, the number of Fos-like immunoreactive neurons relates to the number of items remembered, while the number of ZENK-like immunoreactive neurons in the HF may be related to the accuracy of cache retrieval. These results imply that the brain might process complex information by recruiting more neurons into the network of active neurons. Thus, our results could help explain why food-hoarding birds have more HF neurons than non-hoarders, and why this number increases in autumn when large numbers of food items are cached. PMID:10996045

Smulders, T V; DeVoogd, T J

2000-09-01

489

Cytological and molecular characterization of three gametoclones of Citrus clementina  

PubMed Central

Background Three gametoclonal plants of Citrus clementina Hort. ex Tan., cv. Nules, designated ESP, FRA, and ITA (derived from three labs in Spain, France, and Italy, respectively), were selected for cytological and molecular characterization in order to elucidate genomic rearrangements provoked by haploidization. The study included comparisons of their ploidy, homozygosity, genome integrity, and gene dosage, using chromosome counting, flow cytometry, SSR marker genotyping, and array-Comparative Genomic Hybridization (array-CGH). Results Chromosome counting and flow cytometry revealed that ESP and FRA were haploid, but ITA was tri-haploid. Homozygous patterns, represented by a single peak (allele), were observed among the three plants at almost all SSR loci distributed across the entire diploid donor genome. Those few loci with extra peaks visualized as output from automated sequencing runs, generally low or ambiguous, might result from amplicons of paralogous members at the locus, non-specific sites, or unexpected recombinant alleles. No new alleles were found, suggesting the genomes remained stable and intact during gametogenesis and regeneration. The integrity of the haploid genome also was supported by array-CGH studies, in which genomic profiles were comparable to the diploid control. Conclusions The presence of few gene hybridization abnormalities, corroborated by gene dosage measurements, were hypothetically due to the segregation of hemizygous alleles and minor genomic rearrangements occurring during the haploidization procedure. In conclusion, these plants that are valuable genetic and breeding materials contain completely homozygous and essentially intact genomes. PMID:24020638

2013-01-01

490

Transcriptional regulation of the human bone sialoprotein gene by fibroblast growth factor 2.  

PubMed

Fibroblast growth factor 2 (FGF2), a member of the FGF family, positively regulates bone formation and osteoblast differentiation. Bone sialoprotein (BSP) is highly expressed during early bone formation and may play a role in primary mineralization of bone. In the present study, FGF2 (10 ng/mL) was found to increase the levels of Runx2 and BSP mRNA at 3 and 12 h in human osteoblast-like Saos2 cells. Transient transfection assays were performed using chimeric constructs of the human BSP gene promoter ligated with a luciferase reporter gene. FGF2 (10 ng/mL, 12 h) induced the luciferase activities of the -84LUC and -927LUC constructs in Saos2 cells. The results of gel shift assays showed that FGF2 (10 ng/mL) increased the binding of nuclear protein to the FGF2 response element (FRE) and the activator protein 1 (AP1) binding site. Antibodies against Dlx5, Msx2, Runx2 and Smad1 blocked FRE-protein complex formation, and antibodies against CREB1, c-Jun and Fra2 interrupted AP1-protein complex formation. These results indicate that FGF2 increases BSP transcription by targeting the FRE and AP1 elements in the proximal promoter of the human BSP gene. Moreover, the transcription factors Dlx5, Msx2, Runx2, Smad1, CREB1, c-Jun and Fra2 could be key regulators of the effects of FGF2 on human BSP transcription. PMID:23485603

Zhou, Liming; Ogata, Yorimasa

2013-03-01

491

Antioxidant-induced changes of the AP-1 transcription complex are paralleled by a selective suppression of human papillomavirus transcription.  

PubMed Central

Considering the involvement of a redox-regulatory pathway in the expression of human papillomaviruses (HPVs), HPV type 16 (HPV-16)-immortalized human keratinocytes were treated with the antioxidant pyrrolidine-dithiocarbamate (PDTC). PDTC induces elevated binding of the transcription factor AP-1 to its cognate recognition site within the viral regulatory region. Despite of increased AP-1 binding, normally indispensable for efficient HPV-16 transcription, viral gene expression was selectively suppressed at the level of initiation of transcription. Electrophoretic mobility supershift assays showed that the composition of the AP-1 complex, predominantly consisting of Jun homodimers in untreated cells, was altered. Irrespective of enhanced c-fos expression, c-jun was phosphorylated and became primarily heterodimerized with fra-1, which was also induced after PDTC incubation. Additionally, there was also an increased complex formation between c-jun and junB. Because both fra-1 and junB overexpression negatively interferes with c-jun/c-fos trans-activation of AP-1-responsive genes, our results suggest that the observed block in viral transcription is mainly the consequence of an antioxidant-induced reconstitution of the AP-1 transcription complex. Since expression of the c-jun/c-fos gene family is tightly regulated during cellular differentiation, defined reorganization of a central viral transcription factor may represent a novel mechanism controlling the transcription of pathogenic HPVs during keratinocyte differentiation and in the progression to cervical cancer. PMID:8985358

Rsl, F; Das, B C; Lengert, M; Geletneky, K; zur Hausen, H

1997-01-01

492

QTL analyses and comparative genetic mapping of frost tolerance, winter survival and drought tolerance in meadow fescue (Festuca pratensis Huds.).  

PubMed

Quantitative trait loci (QTLs) for frost and drought tolerance, and winter survival in the field, were mapped in meadow fescue (Festuca pratensis Huds.) and compared with corresponding traits in Triticeae and rice to study co-location with putatively orthologous QTLs and known abiotic stress tolerance genes. The genomes of grass species are highly macrosyntenic; however, the Festuca/Lolium and Triticeae homoeologous chromosomes 4 and 5 show major structural differences that is especially interesting in comparative genomics of frost tolerance. The locations of two frost tolerance/winter survival QTLs on Festuca chromosome 5F correspond most likely to the Fr-A1 and Fr-A2 loci on wheat homoeologous group 5A chromosomes. A QTL for long-term drought tolerance on chromosome 3F (syntenic with rice 1) support evidence from introgression of Festuca genome segments onto homoeologous Lolium chromosomes (3L) that this genome region is an excellent source of tolerance towards drought stress. The coincident location of several stress tolerance QTL in Festuca with QTL and genes in Triticeae species, notably dehydrins, CBF transcription factors and vernalisation response genes indicate the action of structural or regulatory genes conserved across evolutionarily distant species. PMID:21505831

Alm, Vibeke; Busso, Carlos S; Ergon, Ashild; Rudi, Heidi; Larsen, Arild; Humphreys, Michael W; Rognli, Odd Arne

2011-08-01

493

Retinoic Acid Receptors Inhibit AP1 Activation by Regulating Extracellular Signal-Regulated Kinase and CBP Recruitment to an AP1-Responsive Promoter  

PubMed Central

Retinoids exhibit antineoplastic activities that may be linked to retinoid receptor-mediated transrepression of activating protein 1 (AP1), a heterodimeric transcription factor composed of fos- and jun-related proteins. Here we show that transcriptional activation of an AP1-regulated gene through the mitogen-activated protein kinase (MAPK)-extracellular signal-regulated kinase (ERK) pathway (MAPKERK) is characterized, in intact cells, by a switch from a fra2-junD dimer to a junD-fosB dimer loading on its promoter and by simultaneous recruitment of ERKs, CREB-binding protein (CBP), and RNA polymerase II. All-trans-retinoic acid (atRA) receptor (RAR) was tethered constitutively to the AP1 promoter. AP1 transrepression by retinoic acid was concomitant to glycogen synthase kinase 3 activation, negative regulation of junD hyperphosphorylation, and to decreased RNA polymerase II recruitment. Under these conditions, fra1 loading to the AP1 response element was strongly increased. Importantly, CBP and ERKs were excluded from the promoter in the presence of atRA. AP1 transrepression by retinoids was RAR and ligand dependent, but none of the functions required for RAR-mediated transactivation was necessary for AP1 transrepression. These results indicate that transrepressive effects of retinoids are mediated through a mechanism unrelated to transcriptional activation, involving the RAR-dependent control of transcription factors and cofactor assembly on AP1-regulated promoters. PMID:12052862

Benkoussa, Madjid; Brand, Cline; Delmotte, Marie-Hlne; Formstecher, Pierre; Lefebvre, Philippe

2002-01-01

494

Chemical characterization and antiherpes activity of sulfated polysaccharides from Lithothamnion muelleri.  

PubMed

We report herein the chemical characterization and antiherpes activity of polysaccharides from the red alga Lithothamnion muelleri (Hapalidiaceae). The polysaccharide-rich fractions B1 and B2 were obtained by extraction with Na2CO3 and were purified by size exclusion chromatography to afford Fra-B1 and Fra-B2. The polysaccharides were characterized by FT-IR and chemical analysis (total contents of carbohydrates, proteins, sulfate and uronic acid), whereas their average molecular weights were estimated by high performance gel permeation chromatography. The monosaccharide analysis detected galactose, glucose, xylose, mannose, rhamnose and arabinose in the four polysaccharide samples. Antiherpetic in vitro assays showed that B1 and B2 inhibited Herpes Simplex Virus types 1 and 2 (HSV-1 and HSV-2) when added simultaneously to viral infection affording selectivity indices (SI=CC50/EC50) higher than 20. Investigation of the mechanism of action indicated that B1 and B2 act on the initial steps of HSV replication, mainly inhibiting viral adsorption but also viral penetration into the cells. PMID:24608026

Malagoli, Bruna G; Cardozo, Francielle T G S; Gomes, Jose Hugo S; Ferraz, Vany P; Simes, Cludia M O; Braga, Ferno C

2014-05-01

495

The life and times of Big Bertha - Lunar breccia 14321  

NASA Technical Reports Server (NTRS)

The assembly and metamorphic history of polymict breccia 14321 are reconstructed. The earliest formed fragmental component of 14321 (microbreccia-1) is dominated by KREEP-rich norite, extruded and subsequently brecciated and lithified in an ejecta blanket at approximately 1000 C in the general region of Mare Imbrium after the Serenitatis impact but prior to the Imbrium impact. This early microbreccia component and lesser amounts of mare-type basalt, microgranite, rhyolite glass, anorthosite and olivine microbreccia were assembled at the Apollo 14 site as part of the Fra Mauro ejecta blanket from the Imbrium impact. The resulting microbreccia-3 incorporates all the lithic types above and accretionary lapilli structures (microbreccia-2) in a dark matrix annealed at approximately 700 C. A later impact on the Fra Mauro excavated and mutually abraded microbreccia-3 and a local, 14321-type, basalt which were assembled into polymict breccia 14321. Final placement of 14321 at its sampling location was accomplished during the minor Cone Crater impact event.

Duncan, A. R.; Grieve, R. A. F.; Weill, D. F.

1975-01-01

496

Normal number of CGG repeats in the FMR-1 gene and abnormal incorporation of fibrillin into the extracellular matrix in Lujan Syndrome  

SciTech Connect

Lujan syndrome is an X-linked condition that includes mild-to-moderate mental retardation, poor social integration, normal secondary sexual development with normal testicular size, generalized hypotonia, hypernasal voice and dolichostenomelia. Major cardiac complications and lens dislocation have not been reported although severe myopia may occur. All reported cases have had negative cytogenetic screening for fra(X) syndrome but establishing this constellation of findings as a distinctive entity has been difficult. We report 4 males in two sibships with clinical findings consistent with Lujan syndrome, normal karyotypes, negative cytogenetic screening for fra(X) syndrome and a normal number of CGG repeats in the FMR-1 gene. Dermal fibroblasts explanted from one of the affected males were used to study fibrillin synthesis secretion and extracellular matrix incorporation into microfibrils. Cells from the affected individual showed normal synthesis and secretion of fibrillin when compared to control cells, but the fibrillin was not incorporated into the extracellular matrix. These results suggest the presence of a gene on the X chromosome which may play a role in microfibril assembly and when deficient may disrupt the incorporation of fibrillin into microfibrils. This may be important not only in normal body morphogenesis but also in the development/function of the brain. More affected individuals are needed to investigate these findings further.

Greenhaw, G.A.; Stone, C.; Milewicz, D. [Univ. of Texas Health Science Center, Houston, TX (United States)

1994-09-01

497

Optimized Li-Ion Electrolytes Containing Triphenyl Phosphate as a Flame-Retardant Additive  

NASA Technical Reports Server (NTRS)

A number of future NASA missions involving the exploration of the Moon and Mars will be human-rated and thus require high-specific-energy rechargeable batteries that possess enhanced safety characteristics. Given that Li-ion technology is the most viable rechargeable energy storage device for near-term applications, effort has been devoted to improving the safety characteristics of this system. There is also a strong desire to develop Li-ion batteries with improved safety characteristics for terrestrial applications, most notably for hybrid electric vehicle (HEV) and plug-in hybrid electric vehicle (PHEV) automotive applications. Therefore, extensive effort has been devoted recently to developing non-flammable electrolytes to reduce the flammability of the cells/battery. A number of electrolyte formulations have been developed, including systems that (1) incorporate greater concentrations of the flame-retardant additive (FRA); (2) use di-2,2,2-trifluoroethyl carbonate (DTFEC) as a co-solvent; (3) use 2,2,2- trifluoroethyl methyl carbonate (TFEMC); (4) use mono-fluoroethylene carbonate (FEC) as a co-solvent and/or a replacement for ethylene carbonate in the electrolyte mixture; and (5) utilize vinylene carbonate as a "SEI promoting" electrolyte additive, to build on the favorable results previously obtained. To extend the family of electrolytes developed under previous work, a number of additional electrolyte formulations containing FRAs, most notably triphenyl phosphate (TPP), were investigated and demonstrated in experimental MCMB (mesocarbon micro beads) carbon- LiNi(0.8)Co(0.2)O2 cells. The use of higher concentrations of the FRA is known to reduce the flammability of the electrolyte solution, thus, a concentration range was investigated (i.e., 5 to 20 percent by volume). The desired concentration of the FRA is the highest amount tolerable without adversely affecting the performance in terms of reversibility, ability to operate over a wide temperature range, and the discharge rate capability. The use of fluorinated carbonates, much in the same manner as the incorporation of fluorinated ester-based solvents, was employed to reduce the inherent flammability of mixtures. Thus, electrolyte formulations that embody both approaches are anticipated to have much lower flammability, resulting in enhanced safety.

Smart, Marshall C.; Bugga, Ratnakumar V.; Prakash, G. K. Surya; Krause, Frederick C.

2011-01-01

498

Pan-Tropical Forest Mapping by Exploiting Textures of Multi-Temporal High Resolution SAR Data  

NASA Astrophysics Data System (ADS)

Even though the first commitment period of the Kyoto Protocol is in the offing, there is still a strong demand for profound, reliable, and up to date information in order to bridge the gap of knowledge of the land cover conversion. Despite the fact that land use change is one of the largest carbon contribution factors, it is still poorly quantified. This is particularly true for many tropical forest areas worldwide. Here, preservation of such pristine forest areas is critically endangered. Enormous population growth, the increasing global demand for various resources, and the ongoing unsustainable management practices put the remaining tropical forests under a huge pressure. Yet, only the United Nations Food and Agriculture Organization's (FAO) global Forest Resources Assessment (FRA) report provides the crucial quantitative information every 5 years on a regional scale. Nonetheless, the assembled information of the FRA reports bear the burden of ambiguity and vagueness, because they were compiled based on autonomously gathered statistics, which are usually driven by the individual country needs. There is a broad consensus among the different scientific disciplines, that only the remote sensing technology allows for a large scale robust monitoring of these widespread, and remote forest areas. Consequently, the FAO decided to supplementary analyze remote sensing data for the present (2010) and upcoming FRAs. However, it is also widely accepted that currently only microwave remote sensing techniques allow for an all-day, weather independent monitoring of the frequently cloud-covered tropics. In this context, high resolution Synthetic Aperture Radar (SAR) images of the German satellites TerraSAR-X and TanDEM-X have been investigated within the pan-tropics to support the latest FRA 2010 report. Data of more than 304 predominantly cloud-covered sites in Latin America (188), Central Africa (45) and Southeast Asia (71) have been acquired. Upon delivery, the corresponding radar images were processed using an operational processing chain that includes radiometric transformation, noise reduction, and georeferencing of the SAR data. In places with pronounced topography both satellites were used as single pass interferometer to derive a digital surface model in order to perform an orthorectification followed by a topographic normalization of the SAR backscatter values. As prescribed by the FAO, the final segment-based classification algorithm was fed by multi-temporal backscatter information, a set of textural features, and information on the degree of coherence between the multi-temporal acquisitions. Validation with available high resolution optical imagery suggests that the produced forest maps possess an overall accuracy of 75 percent or higher.

Knuth, R.; Eckardt, R.; Richter, N.; Schmullius, C.

2012-12-01

499

Cranio Spinal Irradiation of Medulloblastoma Using High Precision Techniques - A Dosimetric Comparison.  

PubMed

Radiotherapy planning, delivery and junction dose verification remain exigent for Cranio Spinal Irradiation (CSI) in medulloblastoma patients. This study aims to evaluate high precision techniques such as Intensity Modulated Radiation Therapy (IMRT), Rapid Arc Therapy (RA) with and without flattening filter (FF) on the basis of dosimetric analysis. Five patients treated with jagged junction Intensity Modulated RadioTherapy (IMRT) using dynamic Multi Leaf Collimators (MLC) were randomly selected for this retrospective study. IMRT, Rapid Arc (RA) plans were simulated in the same CT data set with and without flattening filter. Total dose prescribed was 28.80 Gy in 16 fractions. An evaluation criterion of 98% of PTV receiving 100% of the prescription dose was followed in all plans. Twenty treatment plans with 260 Dose Volume Histograms (DVHs) was created. Dosimetric parameters such as Dmax, Dmin, Dmean, V95%, V107%, CI for PTV and Dmax, Dmean, V80%, V50%, V30%, V10% for Organs At Risk (OAR) were extracted from DVHs. Treatment delivery efficiency was also evaluated for total Beam On Time (BOT). FFF Rapid Arc therapy (6F_RA) resulted in conformal doses throughout the cranio spinal axis. FF and FFF dynamic IMRT had minimal V107%, 1.23% and 2.88% compared to 49.15 and 66.36 of rapid arc therapy (with and without FF). 6F_IMRT resulted in lesser mean doses to eyes, liver, lungs and kidneys. Heart mean dose was less (3.08 Gy) with 6X_IMRT. Thyroid and esophagus doses could be reduced to about 41.2% and 10% respectively with 6F_RA. The BOT for the treatment techniques were 3.43 min (6X_IMRT), 1.59 min (6F_IMRT), 5min (6X_RA), 4.5 min (6F_RA). Removal of flattening filter in IMRT could improve dose coverage along the caniospinal axis and normal tissue sparing. A reduction of 46.3% BOT could increase treatment efficiency of 6F_IMRT compared to 6X_IMRT. CSI could be simpler since junction doses can be evaded in IMRT and RA techniques. PMID:24645747

Pichandi, A; Ganesh, K M; Jerrin, A; Balaji, K; Sridhar, P S; Surega, A

2014-03-17

500

Chemistry and thermal history of metal particles in Luna 20 soils.  

NASA Technical Reports Server (NTRS)

Individual metal particles from Luna 20 thin sections 521, 513 and 514 as well as several small metallic inclusions in silicate particles from Luna 20 thin sections 501 and 502 were examined using optical microscopy and the electron microprobe. All the metallic particles and inclusions analyzed are of meteoritic Co-Ni content as are most of the metallic particles from the Fra Mauro and the Apollo 16 highlands sites. It is proposed that most of the metal at these 3 sites had its origin in the meteoritic projectiles that bombarded and accumulated in the early lunar crust. It is apparent that the metallic particles and some of the metallic inclusions in the Luna 20 soil have been subjected to reheating on the moon and this process has removed any evidence of the original meteoritic microstructure of the metal.

Goldstein, J. I.; Blau, P. J.

1973-01-01