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Sample records for genstande fra forskningscenter

  1. 49 CFR Appendix C to Part 241 - Geographical Boundaries of FRA's Regions and Addresses of FRA's Regional Headquarters

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Geographical Boundaries of FRA's Regions and Addresses of FRA's Regional Headquarters C Appendix C to Part 241 Transportation Other Regulations Relating... STATES LOCATIONAL REQUIREMENT FOR DISPATCHING OF UNITED STATES RAIL OPERATIONS Pt. 241, App. C Appendix...

  2. 49 CFR Appendix C to Part 241 - Geographical Boundaries of FRA's Regions and Addresses of FRA's Regional Headquarters

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false Geographical Boundaries of FRA's Regions and Addresses of FRA's Regional Headquarters C Appendix C to Part 241 Transportation Other Regulations Relating... STATES LOCATIONAL REQUIREMENT FOR DISPATCHING OF UNITED STATES RAIL OPERATIONS Pt. 241, App. C Appendix...

  3. 49 CFR 219.608 - FRA Administrator's determination of random alcohol testing rate.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...FRA Administrator's determination of random alcohol testing rate. 219.608 Section...TRANSPORTATION CONTROL OF ALCOHOL AND DRUG USE Random Alcohol and Drug Testing Programs ...FRA Administrator's determination of random alcohol testing rate. (a)...

  4. 49 CFR 219.602 - FRA Administrator's determination of random drug testing rate.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...FRA Administrator's determination of random drug testing rate. 219.602 Section...TRANSPORTATION CONTROL OF ALCOHOL AND DRUG USE Random Alcohol and Drug Testing Programs ...FRA Administrator's determination of random drug testing rate. (a) Except...

  5. 49 CFR 219.608 - FRA Administrator's determination of random alcohol testing rate.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...FRA Administrator's determination of random alcohol testing rate. 219.608 Section...TRANSPORTATION CONTROL OF ALCOHOL AND DRUG USE Random Alcohol and Drug Testing Programs ...FRA Administrator's determination of random alcohol testing rate. (a)...

  6. 49 CFR 219.608 - FRA Administrator's determination of random alcohol testing rate.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...FRA Administrator's determination of random alcohol testing rate. 219.608 Section...TRANSPORTATION CONTROL OF ALCOHOL AND DRUG USE Random Alcohol and Drug Testing Programs ...FRA Administrator's determination of random alcohol testing rate. (a)...

  7. 49 CFR 219.608 - FRA Administrator's determination of random alcohol testing rate.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...FRA Administrator's determination of random alcohol testing rate. 219.608 Section...TRANSPORTATION CONTROL OF ALCOHOL AND DRUG USE Random Alcohol and Drug Testing Programs ...FRA Administrator's determination of random alcohol testing rate. (a)...

  8. 49 CFR 219.608 - FRA Administrator's determination of random alcohol testing rate.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...FRA Administrator's determination of random alcohol testing rate. 219.608 Section...TRANSPORTATION CONTROL OF ALCOHOL AND DRUG USE Random Alcohol and Drug Testing Programs ...FRA Administrator's determination of random alcohol testing rate. (a)...

  9. 49 CFR 219.602 - FRA Administrator's determination of random drug testing rate.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...FRA Administrator's determination of random drug testing rate. 219.602 Section...TRANSPORTATION CONTROL OF ALCOHOL AND DRUG USE Random Alcohol and Drug Testing Programs ...FRA Administrator's determination of random drug testing rate. (a) Except...

  10. 49 CFR 219.602 - FRA Administrator's determination of random drug testing rate.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...FRA Administrator's determination of random drug testing rate. 219.602 Section...TRANSPORTATION CONTROL OF ALCOHOL AND DRUG USE Random Alcohol and Drug Testing Programs ...FRA Administrator's determination of random drug testing rate. (a) Except...

  11. 49 CFR 219.602 - FRA Administrator's determination of random drug testing rate.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...FRA Administrator's determination of random drug testing rate. 219.602 Section...TRANSPORTATION CONTROL OF ALCOHOL AND DRUG USE Random Alcohol and Drug Testing Programs ...FRA Administrator's determination of random drug testing rate. (a) Except...

  12. 49 CFR 219.602 - FRA Administrator's determination of random drug testing rate.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...FRA Administrator's determination of random drug testing rate. 219.602 Section...TRANSPORTATION CONTROL OF ALCOHOL AND DRUG USE Random Alcohol and Drug Testing Programs ...FRA Administrator's determination of random drug testing rate. (a) Except...

  13. 49 CFR Appendix C to Part 230 - FRA Inspection Forms

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false FRA Inspection Forms C Appendix C to Part 230 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION STEAM LOCOMOTIVE INSPECTION AND MAINTENANCE STANDARDS Pt. 230, App. C Appendix...

  14. 49 CFR Appendix C to Part 230 - FRA Inspection Forms

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false FRA Inspection Forms C Appendix C to Part 230 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION STEAM LOCOMOTIVE INSPECTION AND MAINTENANCE STANDARDS Pt. 230, App. C Appendix...

  15. Solution structure of the strawberry allergen Fra a 1

    PubMed Central

    Seutter von Loetzen, Christian; Schweimer, Kristian; Schwab, Wilfried; Rösch, Paul; Hartl-Spiegelhauer, Olivia

    2012-01-01

    The PR10 family protein Fra a 1E from strawberry (Fragaria x ananassa) is down-regulated in white strawberry mutants, and transient RNAi (RNA interference)-mediated silencing experiments confirmed that Fra a 1 is involved in fruit pigment synthesis. In the present study, we determined the solution structure of Fra a 1E. The protein fold is identical with that of other members of the PR10 protein family and consists of a seven-stranded antiparallel ?-sheet, two short V-shaped ?-helices and a long C-terminal ?-helix that encompass a hydrophobic pocket. Whereas Fra a 1E contains the glycine-rich loop that is highly conserved throughout the protein family, the volume of the hydrophobic pocket and the size of its entrance are much larger than expected. The three-dimensional structure may shed some light on its physiological function and may help to further understand the role of PR10 proteins in plants. PMID:22913709

  16. TO: Persons Joining the Fermilab (FRA) Staff SUBJECT: Inventions and Employee Patent Agreement

    E-print Network

    Quigg, Chris

    TO: Persons Joining the Fermilab (FRA) Staff SUBJECT: Inventions and Employee Patent Agreement in royalties received from patentable inventions to which FRA, LLC has taken title. As provided in FRA, LLC to sign a patent agreement. The attached form has been developed to comply with this requirement

  17. 49 CFR Appendix C to Part 241 - Geographical Boundaries of FRA's Regions and Addresses of FRA's Regional Headquarters

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...Washington 98660. The fax number is 360-696-7548. The E-mail address of the Regional Administrator for Region 8 is: Dick.Clairmont@fra.dot.gov. [67 FR 75960, Dec. 10, 2002, as amended at 69 FR 30595, May 28,...

  18. 49 CFR Appendix C to Part 241 - Geographical Boundaries of FRA's Regions and Addresses of FRA's Regional Headquarters

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...Washington 98660. The fax number is 360-696-7548. The E-mail address of the Regional Administrator for Region 8 is: Dick.Clairmont@fra.dot.gov. [67 FR 75960, Dec. 10, 2002, as amended at 69 FR 30595, May 28,...

  19. 49 CFR 219.602 - FRA Administrator's determination of random drug testing rate.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false FRA Administrator's determination of random drug... (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION CONTROL OF ALCOHOL AND DRUG USE Random Alcohol and Drug Testing Programs § 219.602 FRA Administrator's determination of random...

  20. 49 CFR 219.602 - FRA Administrator's determination of random drug testing rate.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false FRA Administrator's determination of random drug... (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION CONTROL OF ALCOHOL AND DRUG USE Random Alcohol and Drug Testing Programs § 219.602 FRA Administrator's determination of random...

  1. The AP-1 transcription factor Fra1 inhibits follicular B cell differentiation into plasma cells

    PubMed Central

    Grötsch, Bettina; Brachs, Sebastian; Lang, Christiane; Luther, Julia; Derer, Anja; Schlötzer-Schrehardt, Ursula; Bozec, Aline; Fillatreau, Simon; Berberich, Ingolf; Hobeika, Elias; Reth, Michael; Wagner, Erwin F.; Schett, Georg

    2014-01-01

    The cornerstone of humoral immunity is the differentiation of B cells into antibody-secreting plasma cells. This process is tightly controlled by a regulatory gene network centered on the transcriptional repressor B lymphocyte–induced maturation protein 1 (Blimp1). Proliferation of activated B cells is required to foster Blimp1 expression but needs to be terminated to avoid overshooting immune reactions. Activator protein 1 (AP-1) transcription factors become quickly up-regulated upon B cell activation. We demonstrate that Fra1, a Fos member of AP-1, enhances activation-induced cell death upon induction in activated B cells. Moreover, mice with B cell–specific deletion of Fra1 show enhanced plasma cell differentiation and exacerbated antibody responses. In contrast, transgenic overexpression of Fra1 blocks plasma cell differentiation and immunoglobulin production, which cannot be rescued by Bcl2. On the molecular level, Fra1 represses Blimp1 expression and interferes with binding of the activating AP-1 member c-Fos to the Blimp1 promoter. Conversely, overexpression of c-Fos in Fra1 transgenic B cells releases Blimp1 repression. As Fra1 lacks transcriptional transactivation domains, we propose that Fra1 inhibits Blimp1 expression and negatively controls plasma cell differentiation through binding to the Blimp1 promoter. In summary, we demonstrate that Fra1 negatively controls plasma cell differentiation by repressing Blimp1 expression. PMID:25288397

  2. 49 CFR Appendix C to Part 209 - FRA's Policy Statement Concerning Small Entities

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... hazardous materials shippers meeting the economic criteria established for Class III railroads in 49 CFR... described in Appendix A to 49 CFR part 209, it is FRA's policy to consider a variety of factors in... 49 Transportation 4 2013-10-01 2013-10-01 false FRA's Policy Statement Concerning Small Entities...

  3. 49 CFR Appendix C to Part 209 - FRA's Policy Statement Concerning Small Entities

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... hazardous materials shippers meeting the economic criteria established for Class III railroads in 49 CFR... described in Appendix A to 49 CFR part 209, it is FRA's policy to consider a variety of factors in... 49 Transportation 4 2014-10-01 2014-10-01 false FRA's Policy Statement Concerning Small Entities...

  4. 49 CFR Appendix C to Part 215 - FRA Freight Car Standards Defect Code

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...2013-10-01 2013-10-01 false FRA Freight Car Standards Defect Code C Appendix C to...DEPARTMENT OF TRANSPORTATION RAILROAD FREIGHT CAR SAFETY STANDARDS Pt. 215, App. C Appendix C to Part 215—FRA Freight Car Standards Defect Code The...

  5. 49 CFR Appendix C to Part 215 - FRA Freight Car Standards Defect Code

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...2011-10-01 2011-10-01 false FRA Freight Car Standards Defect Code C Appendix C to...DEPARTMENT OF TRANSPORTATION RAILROAD FREIGHT CAR SAFETY STANDARDS Pt. 215, App. C Appendix C to Part 215—FRA Freight Car Standards Defect Code The...

  6. 49 CFR Appendix C to Part 215 - FRA Freight Car Standards Defect Code

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...2010-10-01 2010-10-01 false FRA Freight Car Standards Defect Code C Appendix C to...DEPARTMENT OF TRANSPORTATION RAILROAD FREIGHT CAR SAFETY STANDARDS Pt. 215, App. C Appendix C to Part 215—FRA Freight Car Standards Defect Code The...

  7. 49 CFR Appendix C to Part 215 - FRA Freight Car Standards Defect Code

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...2014-10-01 2014-10-01 false FRA Freight Car Standards Defect Code C Appendix C to...DEPARTMENT OF TRANSPORTATION RAILROAD FREIGHT CAR SAFETY STANDARDS Pt. 215, App. C Appendix C to Part 215—FRA Freight Car Standards Defect Code The...

  8. 49 CFR Appendix C to Part 215 - FRA Freight Car Standards Defect Code

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...2012-10-01 2012-10-01 false FRA Freight Car Standards Defect Code C Appendix C to...DEPARTMENT OF TRANSPORTATION RAILROAD FREIGHT CAR SAFETY STANDARDS Pt. 215, App. C Appendix C to Part 215—FRA Freight Car Standards Defect Code The...

  9. Widespread FRA1-Dependent Control of Mesenchymal Transdifferentiation Programs in Colorectal Cancer Cells

    PubMed Central

    Diesch, Jeannine; Sanij, Elaine; Gilan, Omer; Love, Christopher; Tran, Hoanh; Fleming, Nicholas I.; Ellul, Jason; Amalia, Marcia; Haviv, Izhak; Pearson, Richard B.; Tulchinsky, Eugene; Mariadason, John M.

    2014-01-01

    Tumor invasion and metastasis involves complex remodeling of gene expression programs governing epithelial homeostasis. Mutational activation of the RAS-ERK is a frequent occurrence in many cancers and has been shown to drive overexpression of the AP-1 family transcription factor FRA1, a potent regulator of migration and invasion in a variety of tumor cell types. However, the nature of FRA1 transcriptional targets and the molecular pathways through which they promote tumor progression remain poorly understood. We found that FRA1 was strongly expressed in tumor cells at the invasive front of human colorectal cancers (CRCs), and that its depletion suppressed mesenchymal-like features in CRC cells in vitro. Genome-wide analysis of FRA1 chromatin occupancy and transcriptional regulation identified epithelial-mesenchymal transition (EMT)-related genes as a major class of direct FRA1 targets in CRC cells. Expression of the pro-mesenchymal subset of these genes predicted adverse outcomes in CRC patients, and involved FRA-1-dependent regulation and cooperation with TGF? signaling pathway. Our findings reveal an unexpectedly widespread and direct role for FRA1 in control of epithelial-mesenchymal plasticity in CRC cells, and suggest that FRA1 plays an important role in mediating cross talk between oncogenic RAS-ERK and TGF? signaling networks during tumor progression. PMID:24658684

  10. Sequence conservation at human and mouse orthologous common fragile regions, FRA3B/FHIT and Fra14A2/Fhit.

    PubMed

    Shiraishi, T; Druck, T; Mimori, K; Flomenberg, J; Berk, L; Alder, H; Miller, W; Huebner, K; Croce, C M

    2001-05-01

    It has been suggested that delayed DNA replication underlies fragility at common human fragile sites, but specific sequences responsible for expression of these inducible fragile sites have not been identified. One approach to identify such cis-acting sequences within the large nonexonic regions of fragile sites would be to identify conserved functional elements within orthologous fragile sites by interspecies sequence comparison. This study describes a comparison of orthologous fragile regions, the human FRA3B/FHIT and the murine Fra14A2/Fhit locus. We sequenced over 600 kbp of the mouse Fra14A2, covering the region orthologous to the fragile epicenter of FRA3B, and determined the Fhit deletion break points in a mouse kidney cancer cell line (RENCA). The murine Fra14A2 locus, like the human FRA3B, was characterized by a high AT content. Alignment of the two sequences showed that this fragile region was stable in evolution despite its susceptibility to mitotic recombination on inhibition of DNA replication. There were also several unusual highly conserved regions (HCRs). The positions of predicted matrix attachment regions (MARs), possibly related to replication origins, were not conserved. Of known fragile region landmarks, five cancer cell break points, one viral integration site, and one aphidicolin break cluster were located within or near HCRs. Thus, comparison of orthologous fragile regions has identified highly conserved sequences with possible functional roles in maintenance of fragility. PMID:11320209

  11. 49 CFR 228.407 - Analysis of work schedules; submissions; FRA review and approval of submissions; fatigue...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...2011-10-01 2011-10-01 false Analysis of work schedules; submissions; FRA...Transportation § 228.407 Analysis of work schedules; submissions; FRA...fatigue mitigation plans. (a) Analysis of work schedules. Each railroad...

  12. RESTRAINT-INDUCED fra-2 AND c-fos EXPRESSION IN THE RAT FOREBRAIN: RELATIONSHIP TO STRESS DURATION

    E-print Network

    Spencer, Robert L.

    RESTRAINT-INDUCED fra-2 AND c-fos EXPRESSION IN THE RAT FOREBRAIN: RELATIONSHIP TO STRESS DURATION forebrain. We examined basal and restraint-in- duced mRNA expression (in situ hybridization) of fra-2). Restraint-induced fra-2 expression was quanti- fied in the prefrontal cortex (PFC), lateral septum (LS

  13. Replication stress induces specific enrichment of RECQ1 at common fragile sites FRA3B and FRA16D

    PubMed Central

    2013-01-01

    Background Stalled replication forks at common fragile sites are a major cause of genomic instability. RecQ helicases, a highly conserved family of DNA-unwinding enzymes, are believed to ease ‘roadblocks’ that pose challenge to replication fork progression. Among the five known RecQ homologs in humans, functions of RECQ1, the most abundant of all, are poorly understood. We previously determined that RECQ1 helicase preferentially binds and unwinds substrates that mimic DNA replication/repair intermediates, and interacts with proteins involved in DNA replication restart mechanisms. Method We have utilized chromatin immunoprecipitation followed by quantitative real-time PCR to investigate chromatin interactions of RECQ1 at defined genetic loci in the presence or absence of replication stress. We have also tested the sensitivity of RECQ1-depleted cells to aphidicolin induced replication stress. Results RECQ1 binds to the origins of replication in unperturbed cells. We now show that conditions of replication stress induce increased accumulation of RECQ1 at the lamin B2 origin in HeLa cells. Consistent with a role in promoting fork recovery or repair, RECQ1 is specifically enriched at two major fragile sites FRA3B and FRA16D where replication forks have stalled following aphidicolin treatment. RECQ1-depletion results in attenuated checkpoint activation in response to replication stress, increased sensitivity to aphidicolin and chromosomal instability. Conclusions Given a recent biochemical observation that RECQ1 catalyzes strand exchange on stalled replication fork structures in vitro, our results indicate that RECQ1 facilitates repair of stalled or collapsed replication forks and preserves genome integrity. Our findings provide the first evidence of a crucial role for RECQ1 at naturally occurring fork stalling sites and implicate RECQ1 in mechanisms underlying common fragile site instability in cancer. PMID:23601052

  14. Signal-dependent fra-2 regulation in skeletal muscle reserve and satellite cells

    PubMed Central

    Alli, N S; Yang, E C; Miyake, T; Aziz, A; Collins-Hooper, H; Patel, K; McDermott, J C

    2013-01-01

    Activator protein-1 (AP-1) is a ubiquitous transcription factor that paradoxically also has some tissue-specific functions. In skeletal muscle cells, we document that the AP-1 subunit, Fra-2, is expressed in the resident stem cells (Pax7-positive satellite cells) and also in the analogous undifferentiated ‘reserve' cell population in myogenic cultures, but not in differentiated myofiber nuclei. Silencing of Fra-2 expression enhances the expression of differentiation markers such as muscle creatine kinase and myosin heavy chain, indicating a possible role of Fra-2 in undifferentiated myogenic progenitor cells. We observed that Fra-2 is a target of cytokine-mediated extracellular signal-regulated kinase-1/2 signaling in cultured muscle cells, and extensive mass spectrometry and mutational analysis identified S320 and T322 as regulators of Fra-2 protein stability. Interestingly, Fra-2 S320 phosphorylation occurs transiently in activated satellite cells and is extinguished in myogenin-positive differentiating cells. Thus, cytokine-mediated Fra-2 expression and stabilization is linked to regulation of myogenic progenitor cells having implications for the molecular regulation of adult muscle stem cells and skeletal muscle regeneration. PMID:23807221

  15. Sequence of the FRA3B common fragile region: implications for the mechanism of FHIT deletion.

    PubMed

    Inoue, H; Ishii, H; Alder, H; Snyder, E; Druck, T; Huebner, K; Croce, C M

    1997-12-23

    The hypothesis that chromosomal fragile sites may be "weak links" that result in hot spots for cancer-specific chromosome rearrangements was supported by the discovery that numerous cancer cell homozygous deletions and a familial translocation map within the FHIT gene, which encompasses the common fragile site, FRA3B. Sequence analysis of 276 kb of the FRA3B/FHIT locus and 22 associated cancer cell deletion endpoints shows that this locus is a frequent target of homologous recombination between long interspersed nuclear element sequences resulting in FHIT gene internal deletions, probably as a result of carcinogen-induced damage at FRA3B fragile sites. PMID:9405656

  16. 49 CFR Appendix C to Part 215 - FRA Freight Car Standards Defect Code

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... of the code is to establish a uniform language among FRA, States, and the railroad industry that will... interference preventing rotation. (F) Has broken beam shelf supports worn so that shelf will not support...

  17. 49 CFR Appendix C to Part 215 - FRA Freight Car Standards Defect Code

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... of the code is to establish a uniform language among FRA, States, and the railroad industry that will... interference preventing rotation. (F) Has broken beam shelf supports worn so that shelf will not support...

  18. 49 CFR Appendix A to Part 229 - Form FRA 6180-49A

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... original document, is not carried in the CFR. Copies of Form FRA F6180-49A are available by contacting the Federal Railroad Administration, Office of Standards and Procedures, 1200 New Jersey Avenue,...

  19. 49 CFR Appendix A to Part 229 - Form FRA 6180-49A

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... original document, is not carried in the CFR. Copies of Form FRA F6180-49A are available by contacting the Federal Railroad Administration, Office of Standards and Procedures, 1200 New Jersey Avenue,...

  20. 75 FR 8785 - Agency Request for Emergency Processing of Collection of Information Associated With FRA's...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-25

    ... ICR, with applicable supporting documentation, may be obtained by calling FRA's Clearance Officers, Mr... toll-free. A copy of this ICR may also be obtained electronically by contacting Mr. Brogan at...

  1. 49 CFR 214.307 - Review and approval of individual on-track safety programs by FRA.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Review and approval of individual on-track safety programs by FRA. 214.307 ...Review and approval of individual on-track safety programs by FRA. (a) Each...not less than one month before its on-track safety program becomes...

  2. 49 CFR 214.307 - Review and approval of individual on-track safety programs by FRA.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Review and approval of individual on-track safety programs by FRA. 214.307 ...Review and approval of individual on-track safety programs by FRA. (a) Each...not less than one month before its on-track safety program becomes...

  3. The F8H Glycosyltransferase is a Functional Paralog of FRA8 Involved in Glucuronoxylan Biosynthesis in Arabidopsis

    EPA Science Inventory

    The FRAGILE FIBER8 gene was previously shown to be required for the biosynthesis of the reducing end tetrasaccharide sequence of glucuronoxylan (GX) in Arabidopsis thaliana. Here, we demonstrate that F8H, a close homolog of FRA8, is a functional ortholog of FRA8 involved in GX bi...

  4. FraH Is Required for Reorganization of Intracellular Membranes during Heterocyst Differentiation in Anabaena sp. Strain PCC 7120 ? †

    PubMed Central

    Merino-Puerto, Victoria; Mariscal, Vicente; Schwarz, Heinz; Maldener, Iris; Mullineaux, Conrad W.; Herrero, Antonia; Flores, Enrique

    2011-01-01

    In the filamentous, heterocyst-forming cyanobacteria, two different cell types, the CO2-fixing vegetative cells and the N2-fixing heterocysts, exchange nutrients and regulators for diazotrophic growth. In the model organism Anabaena sp. strain PCC 7120, inactivation of fraH produces filament fragmentation under conditions of combined nitrogen deprivation, releasing numerous isolated heterocysts. Transmission electron microscopy of samples prepared by either high-pressure cryo-fixation or chemical fixation showed that the heterocysts of a ?fraH mutant lack the intracellular membrane system structured close to the heterocyst poles, known as the honeycomb, that is characteristic of wild-type heterocysts. Using a green fluorescent protein translational fusion to the carboxyl terminus of FraH (FraH-C-GFP), confocal microscopy showed spots of fluorescence located at the periphery of the vegetative cells in filaments grown in the presence of nitrate. After incubation in the absence of combined nitrogen, localization of FraH-C-GFP changed substantially, and the GFP fluorescence was conspicuously located at the cell poles in the heterocysts. Fluorescence microscopy and deconvolution of images showed that GFP fluorescence originated mainly from the region next to the cyanophycin plug present at the heterocyst poles. Intercellular transfer of the fluorescent tracers calcein (622 Da) and 5-carboxyfluorescein (374 Da) was either not impaired or only partially impaired in the ?fraH mutant, suggesting that FraH is not important for intercellular molecular exchange. Location of FraH close to the honeycomb membrane structure and lack of such structure in the ?fraH mutant suggest a role of FraH in reorganization of intracellular membranes, which may involve generation of new membranes, during heterocyst differentiation. PMID:21949079

  5. Visualization of Fra-1/AP-1 activation during LPS-induced inflammatory lung injury using fluorescence optical imaging.

    PubMed

    Rajasekaran, Subbiah; Tamatam, Chandramohan R; Potteti, Haranatha R; Raman, Venu; Lee, Jae-Woo; Matthay, Michael A; Mehta, Dolly; Reddy, Narsa M; Reddy, Sekhar P

    2015-08-15

    Inappropriate lung inflammatory response following oxidant and toxicant exposure can lead to abnormal repair and disease pathogenesis, including fibrosis. Thus early detection of molecular and cellular processes and mediators promoting lung inflammation is necessary to develop better strategies for therapeutic intervention and disease management. Previously, we have shown that transcription factor Fra-1/AP-1 plays key roles in lung inflammatory response, as Fra-1-null mice are less susceptible than wild-type mice to LPS-induced lung injury and mortality. Herein, we developed a transgenic reporter mouse model expressing tdTomato under the control of FRA-1 (human) promoter (referred to as FRA-1(TdTg) mice) to monitor its activation during inflammatory lung injury using fluorescence protein-based optical imaging and molecular analysis in vivo and ex vivo. A higher red fluorescent signal was observed in the lungs of LPS-treated FRA-1(TdTg) mice compared with vehicle controls, and Western blot and qRT-PCR analyses revealed a significant correlation with the FRA-1-tdTomato reporter expression. Immunocolocalization demonstrated expression of FRA-1-tdTomato largely in lung alveolar macrophages and to some extent in epithelial cells. Moreover, we validated these results with a second reporter mouse model that expressed green fluorescent protein upon activation of endogenous Fra-1 promoter. Additionally, we demonstrated increased expression of FRA-1 in alveolar macrophages in human lung instilled with Escherichia coli ex vivo. Collectively, our data obtained from two independent reporter mouse models and from human samples underscore the significance of Fra-1 activation in alveolar macrophages during inflammatory lung injury and may aid in developing strategies to target this transcription factor in lung injury and repair. PMID:26071555

  6. 49 CFR 219.602 - FRA Administrator's determination of random drug testing rate.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false FRA Administrator's determination of random drug testing rate. 219.602 Section 219.602 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION CONTROL OF ALCOHOL AND DRUG USE Random Alcohol and Drug Testing Programs...

  7. Ml selv lysets fart (Samlet pris fra ca. 3500 kr., excl. PC)

    E-print Network

    Uggerhøj, Ulrik I.

    Mål selv lysets fart (Samlet pris fra ca. 3500 kr., excl. PC) Motivation: Det er som bekendt en af de to hjørnesten i den specielle relativitetsteori at lysets fart, c, er konstant og endelig for alle at lysets fart dog er uhyre høj. Dette gør også målingen af c til et lidt krævende eksperiment, men ikke

  8. 49 CFR Appendix C to Part 209 - FRA's Policy Statement Concerning Small Entities

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...and the “excessive demand” provisions of...jurisdictions that serve populations of 50,000 or less constitute...violations were made in good faith e.g., based...the presence of both good faith and prompt remedial...that the entity acted in good faith. FRA staff...

  9. 49 CFR Appendix C to Part 215 - FRA Freight Car Standards Defect Code

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false FRA Freight Car Standards Defect Code C Appendix C... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD FREIGHT CAR SAFETY STANDARDS Pt. 215, App. C Appendix C to... 13/4?. (C)(1) Rim thickness is 11/16? or less; (2) Rim thickness is 5/8? or less; (3) Rim...

  10. 49 CFR Appendix C to Part 215 - FRA Freight Car Standards Defect Code

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false FRA Freight Car Standards Defect Code C Appendix C... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD FREIGHT CAR SAFETY STANDARDS Pt. 215, App. C Appendix C to... 13/4?. (C)(1) Rim thickness is 11/16? or less; (2) Rim thickness is 5/8? or less; (3) Rim...

  11. 49 CFR Appendix C to Part 229 - FRA Locomotive Standards-Code of Defects

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... FR 21121, Mar. 31, 1980, as part of the original document, is not carried in the CFR. ... 49 Transportation 4 2014-10-01 2014-10-01 false FRA Locomotive Standards-Code of Defects C Appendix C to Part 229 Transportation Other Regulations Relating to Transportation (Continued)...

  12. 49 CFR Appendix C to Part 229 - FRA Locomotive Standards-Code of Defects

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... FR 21121, Mar. 31, 1980, as part of the original document, is not carried in the CFR. ... 49 Transportation 4 2013-10-01 2013-10-01 false FRA Locomotive Standards-Code of Defects C Appendix C to Part 229 Transportation Other Regulations Relating to Transportation (Continued)...

  13. The ages of lunar material from Fra Mauro, Hadley Rille, and Spur Crater.

    NASA Technical Reports Server (NTRS)

    Husain, L.; Schaeffer, O. A.; Funkhouser, J.; Sutter, J.

    1972-01-01

    Ar-40/Ar-39 dating techniques were applied to estimate the age of twelve crystalline and fragmented Fra Mauro rock samples and six Hadley Rille and Spur Crater rock samples provided by the Apollo 14 and 15 missions. Genesis histories of some associated lunar surface features are traced back on the basis of obtained rock age values.

  14. Teknologi for et bedre samfunn 1 KPI hndtering: fra mlbart via meningsfylt til

    E-print Network

    Stølen, Ketil

    bedre samfunn · Fra "The balanced scorecard" til arkitektur · Estimering · Impactanalyse · Prioritering mhp resultater/verdier 12 Operasjonalisering av mål https://balancedscorecard.org/Resources/AbouttheBalancedScor ecard/tabid/55/Default.aspx Accessed: 12 March 2014 http://www.activestrategy.com/resources/white-papers/balanced

  15. 75 FR 34213 - Solicitation of Applications and Notice of Funding Availability for the FRA Railroad System...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-16

    ... 13, 2010 (75 FR 27112), the FRA sought applications from interested and responsible parties for two grants: to conduct a Locomotive Biofuel Study, and to conduct a Study of the Use of Bio-based... consult the notice published on May 13, 2010 in the Federal Register (75 FR 27112) for additional...

  16. Tur-retur. Rumsonden Hayabusa er netop landet efter en syvrig mission til den kartoffelformede asteroide Itokawa. Forhbentlig vil prverne fra overfladen give ny

    E-print Network

    Andersen, Anja C.

    asteroide Itokawa. Forhåbentlig vil prøverne fra overfladen give ny viden, blandt andet om hvor meteoritter stammer fra. Forskerne venter i spænding på, at rumkapslen åbnes i Japan. Jorden kalder Itokawa! Af overflademateriale fra asteroiden Itokawa. Hayabusa er en ubemandet rumsonde på godt 500 kilo, der blev opsendt den 9

  17. Requirement of Fra proteins for communication channels between cells in the filamentous nitrogen-fixing cyanobacterium Anabaena sp. PCC 7120.

    PubMed

    Omairi-Nasser, Amin; Mariscal, Vicente; Austin, Jotham R; Haselkorn, Robert

    2015-08-11

    The filamentous nitrogen-fixing cyanobacterium Anabaena sp. PCC 7120 differentiates specialized cells, heterocysts, that fix atmospheric nitrogen and transfer the fixed nitrogen to adjacent vegetative cells. Reciprocally, vegetative cells transfer fixed carbon to heterocysts. Several routes have been described for metabolite exchange within the filament, one of which involves communicating channels that penetrate the septum between adjacent cells. Several fra gene mutants were isolated 25 y ago on the basis of their phenotypes: inability to fix nitrogen and fragmentation of filaments upon transfer from N+ to N- media. Cryopreservation combined with electron tomography were used to investigate the role of three fra gene products in channel formation. FraC and FraG are clearly involved in channel formation, whereas FraD has a minor part. Additionally, FraG was located close to the cytoplasmic membrane and in the heterocyst neck, using immunogold labeling with antibody raised to the N-terminal domain of the FraG protein. PMID:26216997

  18. 49 CFR 229.207 - New locomotive crashworthiness design standards and changes to existing FRA-approved locomotive...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...false New locomotive crashworthiness design standards and changes to existing FRA-approved locomotive crashworthiness design standards. 229.207 Section...STANDARDS Locomotive Crashworthiness Design Requirements § 229.207 New...

  19. The role of deletions at the FRA3B/FHIT locus in carcinogenesis.

    PubMed

    Huebner, K; Druck, T; Siprashvili, Z; Croce, C M; Kovatich, A; McCue, P A

    1998-01-01

    The FHIT gene, which encodes a 1-kb message and a 16.8-kDa protein that hydrolyses diadenosine triphosphate (ApppA) to ADP and AMP in vitro, covers a megabase genomic region at chromosome band 3p14.2. The gene encompasses the most active of the common human chromosomal fragile regions, FRA3B. Over the years, it has been suggested that fragile sites might be especially susceptible to carcinogen damage and that chromosomal regions of nonrandom alterations in cancer cells may coincide with defined fragile sites. Within the FRA3B region, the characteristic induced chromosome gaps can occur across the entire region, but 60% of the gaps are centered on a 300-kb region flanking FHIT exon 5, the first protein-coding exon. Numerous hemizygous and homozygous deletions, translocations and DNA insertions occur within FHIT in cancer cell lines, uncultured tumors, and even in preneoplastic lesions, especially in tissues such as lung that are targets of carcinogens. This supports the proposed cancer-fragile site connection and suggests that the FHIT gene, expression of which is frequently altered in cells showing FHIT locus damage, is a tumor suppressor gene whose inactivation may drive clonal expansion of preneoplastic and neoplastic cells. Replacement of Fhit expression in Fhit-negative cancer cells abrogates their tumorigenicity in nude mice. Analysis of the approximately 300-kb DNA sequence encompassing FHIT exon 5 in the FRA3B epicenter has provided clues to the mechanism of repair of the fragile site double strand breaks. The mechanism involves recombination between LINE 1 elements with deletion of the intervening sequence, often including FHIT exons. These studies have also shown that FHIT alterations generally entail independent deletion of both FHIT alleles. Future studies will focus on two objectives: study of (1) the in vivo function of the Fhit protein and (2) mechanisms of break and repair in the FRA3B fragile region. PMID:10027001

  20. Terminal epidermal differentiation is regulated by the interaction of Fra-2/AP-1 with Ezh2 and ERK1/2

    PubMed Central

    Wurm, Stefanie; Zhang, Jisheng; Guinea-Viniegra, Juan; García, Fernando; Muñoz, Javier; Bakiri, Latifa; Ezhkova, Elena

    2015-01-01

    Altered epidermal differentiation characterizes numerous skin diseases affecting >25% of the human population. Here we identified Fra-2/AP-1 as a key regulator of terminal epidermal differentiation. Epithelial-restricted, ectopic expression of Fra-2 induced expression of epidermal differentiation genes located within the epidermal differentiation complex (EDC). Moreover, in a papilloma-prone background, a reduced tumor burden was observed due to precocious keratinocyte differentiation by Fra-2 expression. Importantly, loss of Fra-2 in suprabasal keratinocytes is sufficient to cause skin barrier defects due to reduced expression of differentiation genes. Mechanistically, Fra-2 binds and transcriptionally regulates EDC gene promoters, which are co-occupied by the transcriptional repressor Ezh2. Fra-2 remains transcriptionally inactive in nondifferentiated keratinocytes, where it was found monomethylated and dimethylated on Lys104 and interacted with Ezh2. Upon keratinocyte differentiation, Fra-2 is C-terminally phosphorylated on Ser320 and Thr322 by ERK1/2, leading to transcriptional activation. Thus, the induction of epidermal differentiation by Fra-2 is controlled by a dual mechanism involving Ezh2-dependent methylation and activation by ERK1/2-dependent phosphorylation. PMID:25547114

  1. Fra-1 is upregulated in lung cancer tissues and inhibits the apoptosis of lung cancer cells by the P53 signaling pathway.

    PubMed

    Zhong, Guangwei; Chen, Xi; Fang, Xia; Wang, Dongsheng; Xie, Mingxuan; Chen, Qiong

    2016-01-01

    Fos-related antigen-1 (Fra-1) is a member of the activator protein-1 transcription factor superfamily. It plays important roles in oncogenesis in various types of malignancies. Herein, we investigated the expression of Fra-1 in lung cancer tissues by qPCR, immunohistochemistry, and western blot technologies. The results showed that Fra-1 was overexpressed in the lung cancer tissues when compared with the level in the adjacent non?cancerous tissues. To explore the possible mechanism of Fra-1 in lung cancer, we elucidated the effect of Fra-1 on the apoptosis of lung cancer H460 cells, and found that the rate of cell apoptosis was decreased in the H460/Fra-1 cells compared with the H460 or H460/vector cells. Cell apoptosis is closely related with a reduction in mitochondrial membrane potential (??m) and an increase in intracellular reactive oxygen species (ROS) and calcium ion (Ca2+) concentrations. Our results showed that overexpression of Fra-1 in the lung cancer H460 cells, led to an increase in ??m and and a decrease in intracellular ROS and Ca2+ concentrations. Furthermore, we found that Fra-1 was correlated with dysregulation of the P53 signaling pathway in lung cancer tissues in vitro. At the same time, we found that Fra-1 overexpression affected the expression of MDM2 and P53 in vivo. In summary, our results suggest that Fra-1 is upregulated in lung cancer tissues and functions by affecting the P53 signaling pathway in lung cancer. PMID:26549498

  2. The Yeast Iron Regulatory Proteins Grx3/4 and Fra2 Form Heterodimeric Complexes Containing a [2Fe-2S] Cluster with Cysteinyl and Histidyl Ligation

    SciTech Connect

    Li, H.; Mapolelo, D; Dingra, N; Naik, S; Lees, N; Hoffman, B; Riggs-Gelasco, P; Huynh, B; Johnson, M; Outten, C

    2009-01-01

    The transcription of iron uptake and storage genes in Saccharomyces cerevisiae is primarily regulated by the transcription factor Aft1. Nucleocytoplasmic shuttling of Aft1 is dependent upon mitochondrial Fe-S cluster biosynthesis via a signaling pathway that includes the cytosolic monothiol glutaredoxins (Grx3 and Grx4) and the BolA homologue Fra2. However, the interactions between these proteins and the iron-dependent mechanism by which they control Aft1 localization are unclear. To reconstitute and characterize components of this signaling pathway in vitro, we have overexpressed yeast Fra2 and Grx3/4 in Escherichia coli. We have shown that coexpression of recombinant Fra2 with Grx3 or Grx4 allows purification of a stable [2Fe-2S]{sup 2+} cluster-containing Fra2-Grx3 or Fra2-Grx4 heterodimeric complex. Reconstitution of a [2Fe-2S] cluster on Grx3 or Grx4 without Fra2 produces a [2Fe-2S]-bridged homodimer. UV?visible absorption and CD, resonance Raman, EPR, ENDOR, M{umlt o}ssbauer, and EXAFS studies of [2Fe-2S] Grx3/4 homodimers and the [2Fe-2S] Fra2-Grx3/4 heterodimers indicate that inclusion of Fra2 in the Grx3/4 Fe-S complex causes a change in the cluster stability and coordination environment. Taken together, our analytical, spectroscopic, and mutagenesis data indicate that Grx3/4 and Fra2 form a Fe-S-bridged heterodimeric complex with Fe ligands provided by the active site cysteine of Grx3/4, glutathione, and a histidine residue. Overall, these results suggest that the ability of the Fra2-Grx3/4 complex to assemble a [2Fe-2S] cluster may act as a signal to control the iron regulon in response to cellular iron status in yeast.

  3. The Yeast Iron Regulatory Proteins Grx3/4 and Fra2 Form Heterodimeric Complexes Containing a [2Fe-2S] Cluster with Cysteinyl and Histidyl Ligation†

    PubMed Central

    Li, Haoran; Mapolelo, Daphne T.; Dingra, Nin N.; Naik, Sunil G.; Lees, Nicolas S.; Hoffman, Brian M.; Riggs-Gelasco, Pamela J.; Huynh, Boi Hanh; Johnson, Michael K.; Outten, Caryn E.

    2009-01-01

    The transcription of iron uptake and storage genes in S. cerevisiae is primarily regulated by the transcription factor Aft1. Nucleocytoplasmic shuttling of Aft1 is dependent upon mitochondrial Fe-S cluster biosynthesis via a signaling pathway that includes the cytosolic monothiol glutaredoxins (Grx3 and Grx4) and the BolA homologue Fra2. However the interactions between these proteins and the iron-dependent mechanism by which they control Aft1 localization are unclear. To reconstitute and characterize components of this signaling pathway in vitro, we have overexpressed yeast Fra2 and Grx3/4 in E. coli. We have shown that co-expression of recombinant Fra2 with Grx3 or Grx4 allows purification of a stable [2Fe-2S]2+ cluster-containing Fra2-Grx3 or Fra2-Grx4 heterodimeric complex. Reconstitution of a [2Fe-2S] cluster on Grx3 or Grx4 without Fra2 produces a [2Fe-2S]-bridged homodimer. UV-visible absorption and CD, resonance Raman, EPR, ENDOR, Mössbauer, and EXAFS studies of [2Fe-2S] Grx3/4 homodimers and the [2Fe-2S] Fra2-Grx3/4 heterodimers indicate that inclusion of Fra2 in the Grx3/4 Fe-S complex causes a change in the cluster stability and coordination environment. Taken together, our analytical, spectroscopic, and mutagenesis data indicate that Grx3/4 and Fra2 form a Fe-S-bridged heterodimeric complex with Fe ligands provided by the active site cysteine of Grx3/4, glutathione, and a histidine residue. Overall, these results suggest that the ability of the Fra2-Grx3/4 complex to assemble a [2Fe-2S] cluster may act as a signal to control the iron regulon in response to cellular iron status in yeast. PMID:19715344

  4. 49 CFR 228.407 - Analysis of work schedules; submissions; FRA review and approval of submissions; fatigue...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...approval; validated models already accepted by FRA...subpart wishes to use a model of human performance...making part or all of the analysis required by paragraph...railroad shall submit the model and evidence in support...Associate Administrator. Decisions of the Associate...

  5. 49 CFR 228.407 - Analysis of work schedules; submissions; FRA review and approval of submissions; fatigue...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...approval; validated models already accepted by FRA...subpart wishes to use a model of human performance...making part or all of the analysis required by paragraph...railroad shall submit the model and evidence in support...Associate Administrator. Decisions of the Associate...

  6. 49 CFR 228.407 - Analysis of work schedules; submissions; FRA review and approval of submissions; fatigue...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...approval; validated models already accepted by FRA...subpart wishes to use a model of human performance...making part or all of the analysis required by paragraph...railroad shall submit the model and evidence in support...Associate Administrator. Decisions of the Associate...

  7. Rb-Sr ages of igneous rocks from the Apollo 14 mission and the age of the Fra Mauro formation.

    NASA Technical Reports Server (NTRS)

    Papanastassiou, D. A.; Wasserburg, G. J.

    1971-01-01

    Internal Rb-Sr isochrons were determined on four basaltic rocks and on a basaltic clast from a breccia from the Fra Mauro landing site. An internal isochron was determined for rock 12004 and yielded a value in agreement with previous results for basaltic rocks from the Apollo 12 site. The crystallization ages for Apollo 14 basalts are only 0.2 to 0.3 AE older than were found for mare basalts from the Sea of Tranquility. Assuming these leucocratic igneous rocks to be representative of the Fra Mauro site, it follows that there were major igneous processes active in these regions, and presumably throughout the highlands, at times only slightly preceding the periods at which the maria were last flooded.

  8. Positions of chromosome 3p14.2 fragile sites (FRA3B) within the FHIT gene.

    PubMed

    Zimonjic, D B; Druck, T; Ohta, M; Kastury, K; Croce, C M; Popescu, N C; Huebner, K

    1997-03-15

    The FHIT gene spans approximately 1 Mb of DNA at chromosome band 3p14.2, which includes the familial renal cell carcinoma chromosome translocation breakpoint (between FHIT exons 3 and 4), the most frequently expressed human constitutive chromosomal fragile site (FRA3B, telomeric to the t(3;8) translocation), and numerous homozygous deletions in various human cancers, frequently involving FHIT exon 5. The FRA3B has previously been shown to represent more than one specific site, and some specific representatives of FRA3B breaks have been shown to fall in two regions, which we know to be in FHIT introns 4 and intron 5. Because breakage and integration of exogenous DNA in this chromosome region is frequent in aphidicolin-treated somatic cell hybrids, cancer cells, and, presumably, aphidicolin-treated normal lymphocytes that exhibit gaps or breaks, we determined by one- and two color fluorescence in situ hybridization, using cosmids covering specific regions of the FHIT gene, that most of the aphidicolin-induced gaps at FRA3B fall within the FHIT gene, with the highest frequency of gaps falling in intron 5 of the FHIT gene, less than 30 kb telomeric to FHIT exon 5. Gaps also occur in intron 4, where a human papillomavirus 16 integration site has been localized, and in intron 3, where the t(3;8) break point is located. These results suggest that the cancer-specific deletions, which frequently involve introns 4 and 5, originated through breaks in fragile sites. PMID:9067288

  9. Cancer-specific chromosome alterations in the constitutive fragile region FRA3B.

    PubMed

    Mimori, K; Druck, T; Inoue, H; Alder, H; Berk, L; Mori, M; Huebner, K; Croce, C M

    1999-06-22

    We have sequenced 870 kilobases of the FHIT/FRA3B locus, from FHIT intron 3 to intron 7. The locus is AT rich (61.5%) and Alu poor (6. 2%), and it apparently does not harbor other genes. In a detailed analysis of the 308-kilobase region between FHIT exon 5 and the telomeric end of intron 3, a region known to encompass a human papillomavirus-16 integration site and two clusters of aphidicolin-induced chromosome 3p14.2 breakpoints, we have precisely mapped 10 deletion and translocation endpoints in cancer-derived cell lines relative to positions of specific repetitive elements, regions of high genome flexibility and aphidicolin-induced breakpoints. Conclusions are (i) that aphidicolin-induced breakpoint clusters fall close to high-flexibility sequences, suggesting that these sequences contribute directly to aphidicolin-induced fragility; (ii) that 9 of the 10 FHIT allelic deletions in cancer cell lines resulted in loss of exons, with 7 deletion endpoints near long interspersed nuclear elements or long terminal repeat elements; and (iii) that cancer-specific deletions encompass multiple high-flexibility genomic regions, suggesting that fragile breaks may occur at these regions, whereas repair of the breaks involves homologous pairing of flanking sequences with concomitant deletion of the damaged fragile sequence. PMID:10377436

  10. Neoplastic transformation of rat thyroid cells requires the junB and fra-1 gene induction which is dependent on the HMGI-C gene product.

    PubMed Central

    Vallone, D; Battista, S; Pierantoni, G M; Fedele, M; Casalino, L; Santoro, M; Viglietto, G; Fusco, A; Verde, P

    1997-01-01

    The expression of the high mobility group I (HMGI)-C chromatin component was shown previously to be essential for the establishment of the neoplastic phenotype in retrovirally transformed thyroid cell lines. To identify possible targets of the HMGI-C gene product, we have analyzed the AP-1 complex in normal, fully transformed and antisense HMGI-C-expressing rat thyroid cells. We show that neoplastic transformation is associated with a drastic increase in AP-1 activity, which reflects multiple compositional changes. The strongest effect is represented by the dramatic junB and fra-1 gene induction, which is prevented in cell lines expressing the antisense HMGI-C. These results indicate that the HMGI-C gene product is essential for the junB and fra-1 transcriptional induction associated with neoplastic transformation. The inhibition of Fra-1 protein synthesis by stable transfection with a fra-1 antisense RNA vector significantly reduces the malignant phenotype of the transformed thyroid cells, indicating a pivotal role for the fra-1 gene product in the process of cellular transformation. PMID:9311991

  11. Selective participation of c-Jun with Fra-2/c-Fos promotes aggressive tumor phenotypes and poor prognosis in tongue cancer.

    PubMed

    Gupta, Shilpi; Kumar, Prabhat; Kaur, Harsimrut; Sharma, Nishi; Saluja, Daman; Bharti, Alok C; Das, Bhudev C

    2015-01-01

    Tongue squamous cell carcinoma (TSCC) is most aggressive head and neck cancer often associated with HR-HPV infection. The role of AP-1 which is an essential regulator of HPV oncogene expression and tumorigenesis is not reported in tongue cancer. One hundred tongue tissue biopsies comprising precancer, cancer and adjacent controls including two tongue cancer cell lines were employed to study the role of HPV infection and AP-1 family proteins. An exclusive prevalence (28%) of HR-HPV type 16 was observed mainly in well differentiated tongue carcinomas (78.5%). A higher expression and DNA binding activity of AP-1 was observed in tongue tumors and cancer cell lines with c-Fos and Fra-2 as the major binding partners forming the functional AP-1 complex but c-Jun participated only in HPV negative and poorly differentiated carcinoma. Knocking down of Fra-2 responsible for aggressive tongue tumorigenesis led to significant reduction in c-Fos, c-Jun, MMP-9 and HPVE6/E7 expression but Fra-1 and p53 were upregulated. The binding and expression of c-Fos/Fra-2 increased as a function of severity of tongue lesions, yet selective participation of c-Jun appears to promote poor differentiation and aggressive tumorigenesis only in HPV negative cases while HPV infection leads to well differentiation and better prognosis preferably in nonsmokers. PMID:26581505

  12. : The role of proto-oncogene Fra-1 in remodeling the tumor microenvironment in support of breast tumor cell invasion and progression

    E-print Network

    Huang, Ching-Tsan

    , tumor-associated macrophage, Fra-1, IL-6/JAK/Stat3 signaling pathway 1982 Rudolf Virchow [1] cytokinechemokine[2] phenotype [3]tumor-associated macrophage, TAMparacrineinvasion [4][5] TAM prognosis #12-Tin Chen April 19th , 2010 The 6th classroom tumor microenvironment, TME metastasistumor-associated

  13. 49 CFR Appendix F to Part 236 - Minimum Requirements of FRA Directed Independent Third-Party Assessment of PTC System Safety...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Third-Party Assessment of PTC System Safety Verification and Validation F Appendix F to Part 236..., MAINTENANCE, AND REPAIR OF SIGNAL AND TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Pt. 236, App. F Appendix F to Part 236—Minimum Requirements of FRA Directed Independent Third-Party Assessment of PTC...

  14. 49 CFR Appendix F to Part 236 - Minimum Requirements of FRA Directed Independent Third-Party Assessment of PTC System Safety...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Third-Party Assessment of PTC System Safety Verification and Validation F Appendix F to Part 236..., MAINTENANCE, AND REPAIR OF SIGNAL AND TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Pt. 236, App. F Appendix F to Part 236—Minimum Requirements of FRA Directed Independent Third-Party Assessment of PTC...

  15. Selective participation of c-Jun with Fra-2/c-Fos promotes aggressive tumor phenotypes and poor prognosis in tongue cancer

    PubMed Central

    Gupta, Shilpi; Kumar, Prabhat; Kaur, Harsimrut; Sharma, Nishi; Saluja, Daman; Bharti, Alok C.; Das, Bhudev C.

    2015-01-01

    Tongue squamous cell carcinoma (TSCC) is most aggressive head and neck cancer often associated with HR-HPV infection. The role of AP-1 which is an essential regulator of HPV oncogene expression and tumorigenesis is not reported in tongue cancer. One hundred tongue tissue biopsies comprising precancer, cancer and adjacent controls including two tongue cancer cell lines were employed to study the role of HPV infection and AP-1 family proteins. An exclusive prevalence (28%) of HR-HPV type 16 was observed mainly in well differentiated tongue carcinomas (78.5%). A higher expression and DNA binding activity of AP-1 was observed in tongue tumors and cancer cell lines with c-Fos and Fra-2 as the major binding partners forming the functional AP-1 complex but c-Jun participated only in HPV negative and poorly differentiated carcinoma. Knocking down of Fra-2 responsible for aggressive tongue tumorigenesis led to significant reduction in c-Fos, c-Jun, MMP-9 and HPVE6/E7 expression but Fra-1 and p53 were upregulated. The binding and expression of c-Fos/Fra-2 increased as a function of severity of tongue lesions, yet selective participation of c-Jun appears to promote poor differentiation and aggressive tumorigenesis only in HPV negative cases while HPV infection leads to well differentiation and better prognosis preferably in nonsmokers. PMID:26581505

  16. 49 CFR Appendix F to Part 236 - Minimum Requirements of FRA Directed Independent Third-Party Assessment of PTC System Safety...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...-critical hardware components if required by FRA for audit to verify whether the railroad, vendor, supplier... the supplier's MTTHE and risk estimates for the PTC system, and the supplier's confidence interval in..., MAINTENANCE, AND REPAIR OF SIGNAL AND TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Pt. 236, App. F...

  17. 49 CFR Appendix F to Part 236 - Minimum Requirements of FRA Directed Independent Third-Party Assessment of PTC System Safety...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...-critical hardware components if required by FRA for audit to verify whether the railroad, vendor, supplier... the supplier's MTTHE and risk estimates for the PTC system, and the supplier's confidence interval in..., MAINTENANCE, AND REPAIR OF SIGNAL AND TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Pt. 236, App. F...

  18. 49 CFR Appendix F to Part 236 - Minimum Requirements of FRA Directed Independent Third-Party Assessment of PTC System Safety...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...-critical hardware components if required by FRA for audit to verify whether the railroad, vendor, supplier... the supplier's MTTHE and risk estimates for the PTC system, and the supplier's confidence interval in..., MAINTENANCE, AND REPAIR OF SIGNAL AND TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Pt. 236, App. F...

  19. Sdan tilgr du IndFak2 via Google Chrome Google har valgt, at Silverlight skal fjernes fra deres Google Chrome browser.

    E-print Network

    Bataillon, Thomas

    Sådan tilgår du IndFak2 via Google Chrome Google har valgt, at Silverlight skal fjernes fra deres Google Chrome browser. På nuværende tidspunkt køres Silverlight ikke automatisk og det skal slås til. I september er det helt slut med at bruge Silverlight i Google Chrome. Når man tilgår IndFak2 i Chrome i dag

  20. In quest of lunar regolith breccias of exotic provenance - A uniquely anorthositic sample from the Fra Mauro (Apollo 14) highlands

    NASA Technical Reports Server (NTRS)

    Jerde, Eric A.; Warren, Paul H.; Morris, Richard V.

    1990-01-01

    Bulk compositions of 21 Apollo regolith breccias were determined using an INAA procedure modified from that of Kallemeyn et al. (1989). With one major exception, namely, the 14076,1 sample, the regolith breccias analyzed were found to be not significantly different from the surfaces from which they were collected. In contrast, the 14076,1 sample from the Fra Mauro (Apollo 14) region is a highly anorthositic regolith breccia from a site where anorthosites are extremely scarce. The sample's composition resembles soils from the Descartes (Apollo 16) highlands. However, the low statistical probability for long-distance horizontal transport by impact cratering, together with the relatively high contents of imcompatible elements in 14076,1 suggest that this regolith breccia originated within a few hundred kilometers of the Apollo 14 site. Its compositional resemblance to ferroan anorthosite strengthens the hypothesis that ferroan anorthosite originated as the flotation crust of a global magmasphere.

  1. Chagas disease-specific antigens: characterization of epitopes in CRA/FRA by synthetic peptide mapping and evaluation by ELISA-peptide assay

    PubMed Central

    2013-01-01

    Background The identification of epitopes in proteins recognized by medically relevant antibodies is useful for the development of peptide-based diagnostics and vaccines. In this study, epitopes in the cytoplasmic repetitive antigen (CRA) and flagellar repetitive antigen (FRA) proteins from Trypanosoma cruzi were identified using synthetic peptide techniques and pooled sera from Chagasic patients. The epitopes were further assayed with an ELISA assay based on synthetic peptides. Methods Twenty-two overlapping synthetic peptides representing the coding sequence of the T. cruzi CRA and FRA proteins were assessed by a Spot-synthesis array analysis using sera donated by patients with Chagas disease. Shorter peptides were selected that represented the determined epitopes and synthesized by solid phase synthesis to evaluate the patterns of cross-reactivities and discrimination through an ELISA-diagnostic assay. Results The peptide Spot-synthesis array successfully identified two IgG antigenic determinants in the CRA protein and four in FRA. Bioinformatics suggested that the CRA antigens were unique to T. cruzi while the FRA antigen showed similarity with sequences present within various proteins from Leishmania sp. Subsequently, shorter peptides representing the CRA-1, CRA-2 and FRA-1 epitopes were synthesized by solid phase synthesis and assayed by an ELISA-diagnostic assay. The CRA antigens gave a high discrimination between Chagasic, Leishmaniasis and T. cruzi-uninfected serum. A sensitivity and specificity of 100% was calculated for CRA. While the FRA antigen showed a slightly lower sensitivity (91.6%), its specificity was only 60%. Conclusions The epitopes recognized by human anti-T. cruzi antibodies have been precisely located in two biomarkers of T. cruzi, CRA and FRA. The results from screening a panel of patient sera through an ELISA assay based on peptides representing these epitopes strongly suggest that the sequences from CRA would be useful for the development of diagnostic reagents that could improve upon the sensitivity and specificity of currently available diagnostic tests. Overall, the results provide further evidence of the usefulness of identifying specific linear B-cell epitopes for improving diagnostic tools. PMID:24299278

  2. Document: FRA Disclosure Form Document #: SO-1 Issue date: 8/21/09 Revision #: 4 Revision date: 2/7/13 This document is uncontrolled when printed. The current version is maintained on the WDRS website.

    E-print Network

    Quigg, Chris

    RESEARCH ALLIANCE, LLC (FRA) DISCLOSURE FORM 1. Are you an owner, partner, director, or officer of any of the portfolio.] _______ YES _______ NO 4. Do you know of any other appearance of potential conflict or personal

  3. Common Chromosome Fragile Sites in Human and Murine Epithelial Cells and FHIT/FRA3B Loss-Induced Global Genome Instability

    PubMed Central

    Hosseini, Seyed Ali; Horton, Susan; Saldivar, Joshua C.; Miuma, Satoshi; Stampfer, Martha R.; Heerema, Nyla A.; Huebner, Kay

    2015-01-01

    Chromosomal positions of common fragile sites differ in lymphoblasts and fibroblasts, with positions dependent on the epigenetically determined density of replication origins at these loci. Because rearrangement of fragile loci and associated loss of fragile gene products are hallmarks of cancers, we aimed to map common fragile sites in epithelial cells, from which most cancers derive. Among the five most frequently activated sites in human epithelial cells were chromosome bands 2q33 and Xq22.1, which are not among top fragile sites identified in lymphoblasts or fibroblasts. FRA16D at 16q23 was among the top three fragile sites in the human epithelial cells examined, as it is in lymphoblasts and fibroblasts, while FRA3B at 3p14.2, the top fragile locus in lymphoblasts, was not fragile in most epithelial cell lines tested. Epithelial cells exhibited varying hierarchies of fragile sites; some frequent epithelial cell fragile sites are apparently not frequently altered in epithelial cancers and sites that are frequently deleted in epithelial cancers are not necessarily among the most fragile. Since we have reported that loss of expression of the FRA3B-encoded FHIT protein causes increased replication stress-induced DNA damage, we also examined the effect of FHIT-deficiency on markers of genome instability in epithelial cells. FHIT-deficient cells exhibited increases in fragile breaks and in ?H2AX and 53BP1 foci in G1 phase cells, confirming in epithelial cells that the FHIT gene and encompassing FRA3B, is a “caretaker gene” necessary for maintenance of genome stability. PMID:23929738

  4. Sources of clasts in terrestrial impact melts - Clues to the origin of LKFM. [Low-K Fra Mauro

    NASA Technical Reports Server (NTRS)

    Mccormick, K. A.; Taylor, G. J.; Keil, K.; Spudis, P. D.; Grieve, R. A. F.

    1989-01-01

    Low-K Fra Mauro (LKFM) 'basalt', which is found exclusively as an impact melt rock, cannot be modeled geochemically from its clast population or from any combination of known pristine lunar rock types. To clarify clast/melt relationships, a study was made of impact melt rocks from Mistastin Lake crater, Labrador, where there are only three target rocks: anorthosite, quartz monzonite, and granodiorite. Feldspar compositions in these rocks define distinct fields on the An-Ab-Or ternary diagram, making it possible to identify the source of each feldspar clast. Clasts in the Mistastin impact melts do not reflect the abundance of target rocks melted during the impact. The abundance of anorthosite in the clast population varies from 34 to 100 percent compared to a relatively constant value of 65 percent calculated to be in the melt matrix. Therefore the clasts appear to be derived predominantly from material relatively far removed from the zone of impact melting. Melt-matrix composition is dictated strictly by the composition of the target materials within a small radius around and below the point of impact. This suggests that the LKFM composition was derived from a lower crustal source.

  5. Serum from patients with ankylosing spondylitis can increase PPARD, fra-1, MMP7, OPG and RANKL expression in MG63 cells

    PubMed Central

    Hu, Zaiying; Lin, Dongfang; Qi, Jun; Qiu, Minli; Lv, Qing; Li, Qiuxia; Lin, Zhiming; Liao, Zetao; Pan, Yunfeng; Jin, Ou; Wu, Yuqiong; Gu, Jieruo

    2015-01-01

    OBJECTIVES: To explore the effects of serum from patients with ankylosing spondylitis on the canonical Wnt/?-catenin pathway and to assess whether the serum has an osteogenic effect in MG63 cells. METHODS: MG63 cells were cultured with serum from 45 ankylosing spondylitis patients, 30 healthy controls, or 45 rheumatoid arthritis patients. The relative PPARD, fra-1, MMP7, OPG and RANKL mRNA levels were measured using quantitative real-time polymerase chain reaction. Associations between gene expression and patient demographics and clinical assessments were then analyzed. RESULTS: MG63 cells treated with serum from ankylosing spondylitis patients had higher PPARD, fra-1, MMP7 and OPG gene expression than did cells treated with serum from controls or rheumatoid arthritis patients (all p<0.05). RANKL expression was higher in MG63 cells treated with serum from patients with ankylosing spondylitis or rheumatoid arthritis than in those treated with serum from controls (both p<0.05). The OPG/RANKL ratio was also higher in MG63 cells treated with serum from ankylosing spondylitis patients than in those treated with serum from controls (p<0.05). No associations were found between the expression of the five genes and the patient demographics and clinical assessments (all p>0.05). CONCLUSIONS : Serum from ankylosing spondylitis patients increases PPARD, fra-1, MMP7, OPG and RANKL expression and the OPG/RANKL ratio in MG63 cells; these effects may be due to the stimulatory effect of the serum on the Wnt pathway. PMID:26602520

  6. Forest cover maps of China in 2010 from multiple approaches and data sources: PALSAR, Landsat, MODIS, FRA, and NFI

    NASA Astrophysics Data System (ADS)

    Qin, Yuanwei; Xiao, Xiangming; Dong, Jinwei; Zhang, Geli; Shimada, Masanobu; Liu, Jiyuan; Li, Chungan; Kou, Weili; Moore, Berrien

    2015-11-01

    Forests and their changes are important to the regional and global carbon cycle, biodiversity and ecosystem services. Some uncertainty about forest cover area in China calls for an accurate and updated forest cover map. In this study, we combined ALOS PALSAR orthorectified 50-m mosaic images (FBD mode with HH and HV polarization) and MODIS time series data in 2010 to map forests in China. We used MODIS-based NDVI dataset (MOD13Q1, 250-m spatial resolution) to generate a map of annual maximum NDVI and used it to mask out built-up lands, barren lands, and sparsely vegetated lands. We developed a decision tree classification algorithm to identify forest and non-forest land cover, based on the signature analysis of PALSAR backscatter coefficient data. The PALSAR-based algorithm was then applied to produce a forest cover map in China in 2010. The resulting forest/non-forest classification map has an overall accuracy of 96.2% and a Kappa Coefficient of 0.91. The resultant 50-m PALSAR-based forest cover map was compared to five forest cover databases. The total forest area (2.02 × 106 km2) in China from the PALSAR-based forest map is close to the forest area estimates from China National Forestry Inventory (1.95 × 106 km2), JAXA (2.00 × 106 km2), and FAO FRA (2.07 × 106 km2). There are good linear relationships between the PALSAR-based forest map and the forest maps from the JAXA, MCD12Q1, and NLCD-China datasets at the province and county scales. All the forest maps have similar spatial distributions of forest/non-forest at pixel scale. Our PALSAR-based forest map recognizes well the agro-forests in China. The results of this study demonstrate the potential of integrating PALSAR and MODIS images to map forests in large areas. The resultant map of forest cover in China in 2010 can be used for many studies such as forest carbon cycle and ecological restoration.

  7. Keywords. d(GGC/GCC)5; d(CAG/CTG)5; hairpin structure; model building; molecular mechanics; quadruplex structure Abbreviations used: DM, dystrophia myotonica; FraX, fragile X syndrome; HD, Huntington disease; rms, root mean square.

    E-print Network

    Bansal, Manju

    ; HD, Huntington disease; rms, root mean square. J. Biosci. | Vol. 26 | No. 5 | December 2001 | 649 myotonica, DM), fragile X syndrome (FraX), Huntington disease (HD), several spinocerebellar ataxias of the Huntington's gene (Huntington's disease collaborative research group 1993). However, the following properties

  8. Candidate tumor suppressor genes at FRA7G are coamplified with MET and do not suppress malignancy in a gastric cancer.

    PubMed

    Han, Shuang-Yin; Druck, Teresa; Huebner, Kay

    2003-02-01

    Common fragile sites predispose to specific chromosomal breakage associated with deletion, amplification, and/or translocation in certain forms of cancer. Chromosomal fragile sites not only are susceptible to DNA instability in cancer cells, but may also be associated with genes that contribute to the neoplastic process. FRA7G is a common fragile site containing the candidate tumor suppressor genes CAV1, CAV2, and TESTIN (TES). The human gastric cancer cell line GTL-16 has an amplification of this genomic region and was used to seek evidence for the suppressor candidacy of one of these genes. Our results demonstrate that CAV1, CAV2, and TESTIN are coamplified with the MET oncogene and overexpressed in GTL-16. Somatic mutation was not detected in the coding regions of these genes, although they were each overexpressed. The results show that CAV1, CAV2, and TESTIN are not tumor suppressor genes in this gastric cancer. PMID:12620387

  9. Potential gastrointestinal tumor suppressor locus at the 3p14.2 FRA3B site identified by homozygous deletions in tumor cell lines.

    PubMed

    Kastury, K; Baffa, R; Druck, T; Ohta, M; Cotticelli, M G; Inoue, H; Negrini, M; Rugge, M; Huang, D; Croce, C M; Palazzo, J; Huebner, K

    1996-03-01

    A number of DNA fragments, identified by representational difference analysis, which were homozygously deleted in various cancer cell lines were previously mapped to human chromosomal arms. One of these, BE758-6, which was homozygously deleted in a number of colon carcinoma cell lines, had been mapped to chromosome region 3p. We have further localized the probe to 3p14.2, approximately 350kbp telomeric to the 3p14.2 break of the t(3;8) hereditary renal cell carcinoma chromosome translocation, within or near the 3p14.2 FRA3B, the most common human fragile site. We determined the sizes of the homozygous deletions in a number of cancer cell lines after isolation of a yeast artificial chromosome contig and development of STS markers which fall between D3S1234 and D2S1481, which flank the deletions. Homozygous deletions were observed and sized not only in the cell lines originally reported but also in a number of nasopharyngeal carcinoma cell lines and a gastric carcinoma cell line. About 50% of uncultured stomach and colon carcinomas were then shown to lose heterozygosity for alleles in the same region, with a common region of loss between the D3S1234 and D3S1481 markers. Thus, it is likely that the homozygous deletion observed in these cancer cell lines harbors an important tumor suppressor gene for several tumor types. PMID:8640789

  10. A Comparison of Forest Cover Maps in China in 2010 from Multi-source: Landsat, PALSAR, MCD12Q1, FAO FRA, and National Forestry Inventory

    NASA Astrophysics Data System (ADS)

    Qin, Y.; Xiao, X.; Dong, J.; Zhang, G.

    2014-12-01

    Forests and their changes are quite important to global carbon cycle, biodiversity and ecological services. Some uncertainties about forest cover maps still exist in China, so an accurate and updated forest cover distribution map is necessary as a baseline for carbon cycle estimation, especially at a fine spatial resolution. In this study, we developed a decision tree classification algorithm to identify forest and non-forest land cover, based on the signature analysis of 50 m ALOS PLASAR backscatter data in 2010 for a few land cover types. We used MODIS-based NDVI dataset in 2010 (MOD13Q1) to generate a map of annual maximum NDVI and used it to mask out built-up lands, barren lands, and sparsely vegetated lands. We applied the PALSAR-based algorithm and produced a forest cover map in China in 2010. Several comparisons in forest area and spatial distribution between the resultant forest map with other forest maps were carried out. The results show that the total forest area in China from the PALSAR-based forest map in 2010 is close to those of JAXA, FAO FRA, and National Forestry Inventory, and there are good linear relationships between the PALSAR-based forest map with the JAXA, MCD12Q1, and NLCD-China forest areas at province and county scales. All the forest maps have similar forest/non-forest distribution, but our PALSAR-based forest map recognizes well the agro-forests. The results of this study provide a baseline map of forest cover in China in 2010, which can be used for the studies of forest disturbance, carbon cycle, and ecological restoration projects in China.

  11. Variations in the FRA10AC1 Fragile Site and 15q21 Are Associated with Cerebrospinal Fluid A?1-42 Level

    PubMed Central

    Li, Qingqin S.; Parrado, Antonio R.; Samtani, Mahesh N.; Narayan, Vaibhav A.

    2015-01-01

    Proteolytic fragments of amyloid and post-translational modification of tau species in Cerebrospinal fluid (CSF) as well as cerebral amyloid deposition are important biomarkers for Alzheimer’s Disease. We conducted genome-wide association study to identify genetic factors influencing CSF biomarker level, cerebral amyloid deposition, and disease progression. The genome-wide association study was performed via a meta-analysis of two non-overlapping discovery sample sets to identify genetic variants other than APOE ?4 predictive of the CSF biomarker level (A?1–42, t-Tau, p-Tau181P, t-Tau:A?1–42 ratio, and p-Tau181P:A?1–42 ratio) in patients enrolled in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) study. Loci passing a genome-wide significance threshold of P < 5 x 10?8 were followed-up for replication in an independent sample set. We also performed joint meta-analysis of both discovery sample sets together with the replication sample set. In the discovery phase, we identified variants in FRA10AC1 associated with CSF A?1–42 level passing the genome-wide significance threshold (directly genotyped SNV rs10509663 PFE = 1.1 x 10?9, imputed SNV rs116953792 PFE = 3.5 x 10?10), rs116953792 (Pone-sided = 0.04) achieved replication. This association became stronger in the joint meta-analysis (directly genotyped SNV rs10509663 PFE = 1.7 x 10?9, imputed SNV rs116953792 PFE = 7.6 x 10?11). Additionally, we identified locus 15q21 (imputed SNV rs1503351 PFE = 4.0 x 10?8) associated with CSF A?1–42 level. No other variants passed the genome-wide significance threshold for other CSF biomarkers in either the discovery sample sets or joint analysis. Gene set enrichment analyses suggested that targeted genes mediated by miR-33, miR-146, and miR-193 were enriched in various GWAS analyses. This finding is particularly important because CSF biomarkers confer disease susceptibility and may be predictive of the likelihood of disease progression in Alzheimer’s Disease. PMID:26252872

  12. Fra leggi fisiche ed equazioni matematiche

    NASA Astrophysics Data System (ADS)

    Castaldi, Francesco

    2006-04-01

    The author deals with the common names usually given to mathematical expressions. Newton's law of universal gravitation was never expressed by Newton in the complete form presented below as equation number 1. A different case is represented by Kepler's equation indicated here as equation number 4. That formula contains the definition of a uniform angular motion for the mean anomaly, which Kepler constantly refused and substituted with an area measure for this anomaly. The author would like to suggest two names to be remembered for these mathematical expressions: Henry Cavendish, for the first, and Leonard Euler, for the second.

  13. Apollo 14: Science at Fra Mauro.

    ERIC Educational Resources Information Center

    National Aeronautics and Space Administration, Washington, DC.

    The many scientific activities and experiments performed during the Apollo 14 Mission are presented in a descriptive, non-technical format. Content relates to experiments on the lunar surface and to those performed while traveling in space, and provides a great deal of information about the flight. Many photographs from the journey, a map of the…

  14. Denne rapport omhandler 169 frdigbehandlede sager fra Danmark, heraf 148 fra 2004. Heri ind-

    E-print Network

    Thorup, Kasper

    godkendte sager blev dokumenteret ved hjælp af foto, video eller bånd. For Grønland færdigbehandledes ingen dokumenteret med foto (Foto), video- film (Video), lydoptagelse (Bånd) eller dødfunden fugl (Død). Desuden er

  15. Nets Information Security Risikoanalyse og testing: med perspektiv fra frontlinjen

    E-print Network

    Stølen, Ketil

    Operational management 2nd Line of Defence Control, policy and framework 3rd Line of Defence Audit 1 2 3 1 2 3 Security, BUs/GUs & Management Control Activities 1 2 Orientation Compliance Business Risk #12;C l i c k t s t y l e s 3 Nets #12;C l i c k t o e d i t M a s t e r t e x t s t y l e s Three lines of defence Risk

  16. Processi e Thread Meccanismi di comunicazione fra processi (IPC)

    E-print Network

    Masulli, Francesco

    tempo ­ Turnaround Time (tempo medio di completamento)- minimizzare il tempo di permanenza di un job nel sistema · Sistemi interattivi ­ Response time - minimizzare il tempo di riposta agli eventi ­ Proportionality - assicurare che il tempo di risposta sia proporzionale alla complessità dell'azione richiesta #12

  17. Lunar surface closeup stereoscopic photography at Fra Mauro (Apollo 14 site)

    NASA Technical Reports Server (NTRS)

    Carrier, W. D., III; Heiken, G.

    1972-01-01

    A total of 17-1/2 stereopairs of lunar surface rocks and soil was taken on the Apollo 14 mission. The closeup stereopair photographs are presented with a preliminary interpretation for those interested in lunar soil formation, impact phenomena, and soil mechanics.

  18. 75 FR 59322 - Notice of Availability of Answers to Frequently Asked Questions Regarding Buy America & FRA's...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-27

    ..., 2000 (65 FR 19477), or visit http://www.regulations.gov . FOR FURTHER INFORMATION CONTACT: For... Passenger Rail (HSIPR) Interim Guidance (74 FR 29900 (June 23, 2009)) and as further detailed in a second set of HSIPR interim program guidance governing the distribution of fiscal year 2010 funding (75...

  19. 75 FR 27112 - Solicitation of Applications and Notice of Funding Availability for the FRA Railroad System...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-13

    ...)). Eligible projects will include dynamic testing of locomotives, rolling stock and other rail equipment, with... lubricants in railroad equipment. Dynamic testing of the biofuel blends and bio-based lubricants can be... equipment parts and components; (3) the ability to conduct dynamic testing of the biofuel blends or...

  20. Exposure ages and neutron capture record in lunar samples from Fra Mauro.

    NASA Technical Reports Server (NTRS)

    Lugmair, G. W.; Marti, K.

    1972-01-01

    Cosmic-ray exposure ages of Apollo 14 rocks and rock fragments obtained by the Kr81-Kr83 method range from 27 to 700 m.y. Rock 14321, collected near the Cone crater rim, is one of the many approximately 27 m.y. old ejecta which were reported at the Third Lunar Science Conference. All the other rocks have considerably higher exposure ages. Isotopic anomalies from neutron capture in gadolinium, bromine, and barium are used to obtain information on the lunar neutron spectrum at various depths below the lunar surface. The flux ratio of resonance and slow (less than 0.3 eV) neutrons is found to be nearly constant in the topmost approximately 100 g/sq cm.

  1. Fri prosjektsttte: Nye prosjekter innenfor matematikk, naturvitenskap og teknologi (FRINATEK) fra 2014 Prosjekt Tittel Prosjektansvarlig

    E-print Network

    Brandenburg, Axel

    and Effects of the Earth's Largest Ice and Freshwater Pathway Uni Research AS 231621 Coupled processes in gas Universitet 231252 TSUNAMIs induced by large LANDslides Stiftelsen Norges Geotekniske Institutt 231658 Opto

  2. 75 FR 8785 - Agency Request for Emergency Processing of Collection of Information Associated With FRA's...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-25

    ...Positive Train Control Grant Program After Publication of Second Agency Federal Register...Positive Train Control Grant Funding AGENCY: Federal Railroad...will begin accepting grant applications 10 days...publication of the separate agency notice...

  3. EUROGRAPHICS 2000 / M. Gross and F.R.A. Hopgood (Guest Editors)

    E-print Network

    Lee, WonSook

    specified in the VRML H-Anim 1.1 format is used to generate an individualized virtual human. The system has two steps: (i) feature points specification, which enables automatic silhouette detection in an arbitrary background (ii) two-stage body modification by using feature points and body silhouette

  4. 75 FR 34213 - Solicitation of Applications and Notice of Funding Availability for the FRA Railroad System...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-16

    ...responsible parties for two grants: to conduct a Locomotive Biofuel Study, and to conduct a Study of the Use of Bio-based Technologies...for the two grant programs: (1) To conduct a Locomotive Biofuel Study, and (2) to conduct a Study of the Use of...

  5. 75 FR 27112 - Solicitation of Applications and Notice of Funding Availability for the FRA Railroad System...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-13

    ...grants: (1) To conduct a Locomotive Biofuel Study, and (2) to conduct a Study of...Protection Agency, to conduct a ``Locomotive Biofuel Study.'' This study will focus on determining...other passenger rail operators could use biofuel blends to power locomotives and...

  6. 49 CFR 242.103 - Approval of design of individual railroad programs by FRA.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... CONDUCTORS Program and Eligibility Requirements § 242.103 Approval of design of individual railroad programs... the training of conductors and thereby obtain authority for that railroad to initially certify a person as a conductor in an appropriate type of service; or (2) To recertify only conductors...

  7. "Speech Act" Fra Teoria e Prassi Didattica. (The Speech Act between Theory and Pedagogical Practice).

    ERIC Educational Resources Information Center

    Minardi, Giovanni

    1982-01-01

    The author traces the development of speech act theory from Wittgenstein and Austin through Searle to Grice and shows how their work led to the notional functional approach to language teaching, which is based on the learner and his/her communicative needs. (CFM)

  8. 75 FR 59322 - Notice of Availability of Answers to Frequently Asked Questions Regarding Buy America & FRA's...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-27

    ...of Availability of Answers to Frequently Asked Questions Regarding Buy America...the availability of Answers to Frequently Asked Questions regarding Buy America...Rail Program. The Answers to Frequently Asked Questions can be found on...

  9. Geomorphology of crater and basin deposits - Emplacement of the Fra Mauro formation

    NASA Technical Reports Server (NTRS)

    Morrison, R. H.; Oberbeck, V. R.

    1975-01-01

    Characteristics of continuous deposits near lunar craters larger than about 1 km wide are considered, and it is concluded that (1) concentric dunes, radial ridges, and braided lineations result from deposition of the collision products of ejecta from adjacent pairs of similarly oriented secondary-crater chains and are, therefore, concentrations of secondary-crater ejecta; (2) intracrater ridges are produced within preexisting craters surrounding a fresh primary crater by ricocheting and focusing of secondary-crater ejecta from the preexisting craters' walls; and (3) secondary cratering has produced many of the structures of the continuous deposits of relatively small lunar craters and is the dominant process for emplacement of most of the radial facies of the continuous deposits of large lunar craters and basins. The percentages of Imbrium ejecta in deposits and the nature of Imbrium sculpturing are investigated.

  10. ARBEJDSDAG FOR 2G FRA LANGK R GYMNASIUM MATEMATIKKEN BAG KRYPTERING OG SIGNERING V.HJ.A. RSA

    E-print Network

    Hansen, Johan P.

    tal 1 3. Regning med rester 2 4. Kryptering og signering ved hj#26;lp af et o#11;entligt n#28;gle;sning, afsnit 4 #15; 13:15-14 #31;velser 2. Indbyrdes primiske hele tal De#12;nition 1. To hele tal m; n #30;(m) betegner vi antallet af positive hele tal mindre end m, der er indbyrdes primiske med m (Euler

  11. 10-1 (6/24/02) 10.15 FRA TERNITY A ND SORORITY HOUSING POLICY

    E-print Network

    recognizes that the presence of fraternity and sorority organizations at CSM has a beneficial effect upon organization registered through the Office of Student Life; 3. Be "dry," or alcohol-free; 4. Be willing of residence halls specifically dedicated to fraternity and sorority organizations. This policy shall supersede

  12. P uddannelsen elektronikingenirer lrer du at udvikle og de-signe elektronikprodukter lige fra forbrugerelektronik til avance-

    E-print Network

    Bataillon, Thomas

    undervisningsformer ser dagens lys. Du undervises eksempelvis via Flipped Classroom, og du har også mulighed hverdag. FLIPPED CLASSROOM Undervisningsformen "Flipped Classroom" foregår ved, at du forud

  13. Over half of breakpoints in gene pairs involved in cancer-specific recurrent translocations are mapped to human chromosomal fragile sites.

    E-print Network

    Burrow, Allison A.; Williams, Laura E.; Pierce, Levi C. T.; Wang, Yuh-Hwa

    2009-01-30

    Acute lymphoblastic leukemia t(12;22)(q13;q12) EWSR1 FRA22B ATF1 FRA12A Soft tissue tumor t(2;22)(q33;q12) EWSR1 FRA22B CREB1 FRA2I Angiomatoid fibrous histiocytoma inv(22)(q12q12) EWSR1 FRA22B PATZ1 FRA22B Small round cell tumor t(6;22)(p21;q12) EWSR1... FRA22B POU5F1 FRA6H Undifferentiated bone tumor t(2;22)(q31;q12) EWSR1 FRA22B SP3 FRA2G Ewing tumor/small round cell tumor t(11;22)(p13;q12) EWSR1 FRA22B WT1 FRA11E Soft tissue tumor del(4)(q12q12)d FIP1L1 FRA4B PDGFRA FRA4B Hypereosinophilic syndrome...

  14. Ideo Population: how much do numbers count?____~ _il_l_a_ss_i,_n(_)!~ivi Bacc,: Fra~Jle number th~()reJJ'--___________ :10

    E-print Network

    Cohen, Joel E.

    died before 1930 had lived through a doubling of the human population. No person born in 2050 or later is likely to live through a doubling of the human population. In con- trast, everyone born in 1965.8 billion in 2009. The peak population growth rate ever reached - ahout 2.1 o/c; a year - OCCUlTed hetween

  15. Copy number and haplotype variation at the VRN-A1 and central FR-A2 loci are associated with frost tolerance in hexaploid wheat

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Frost tolerance is a key trait to ensure winter wheat survival. Natural variation for this trait is mainly associated with allelic differences at the VERNALIZATION 1 (VRN1) and FROST RESISTANCE 2 (FR2) loci. VRN1 regulates the transition between vegetative and reproductive stages and FR2, a locus in...

  16. 49 CFR Appendix B to Part 221 - Approved Rear End Marking Devices

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... for or by manufacturers 1. Manufacturer: Star Headlight & Lantern Co., 168 West Main Street, Honeoye Falls, NY 14472. FRA identification Nos. FRA-PLE-STAR-845-F (flasher) and FRA-PLE-STAR-845-C...

  17. 49 CFR Appendix B to Part 221 - Approved Rear End Marking Devices

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... for or by manufacturers 1. Manufacturer: Star Headlight & Lantern Co., 168 West Main Street, Honeoye Falls, NY 14472. FRA identification Nos. FRA-PLE-STAR-845-F (flasher) and FRA-PLE-STAR-845-C...

  18. 49 CFR Appendix B to Part 221 - Approved Rear End Marking Devices

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... for or by manufacturers 1. Manufacturer: Star Headlight & Lantern Co., 168 West Main Street, Honeoye Falls, NY 14472. FRA identification Nos. FRA-PLE-STAR-845-F (flasher) and FRA-PLE-STAR-845-C...

  19. 49 CFR Appendix B to Part 221 - Approved Rear End Marking Devices

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... for or by manufacturers 1. Manufacturer: Star Headlight & Lantern Co., 168 West Main Street, Honeoye Falls, NY 14472. FRA identification Nos. FRA-PLE-STAR-845-F (flasher) and FRA-PLE-STAR-845-C...

  20. 49 CFR Appendix B to Part 221 - Approved Rear End Marking Devices

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... for or by manufacturers 1. Manufacturer: Star Headlight & Lantern Co., 168 West Main Street, Honeoye Falls, NY 14472. FRA identification Nos. FRA-PLE-STAR-845-F (flasher) and FRA-PLE-STAR-845-C...

  1. 76 FR 50359 - Hours of Service of Railroad Employees; Substantive Regulations for Train Employees Providing...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-12

    ... comments in response to FRA's March 22, 2011 proposed rule in this rulemaking (76 FR 16200), FRA issues... Public Law 110-432, Div. A, and FRA Interim Statement of Agency Policy and Interpretation at 74 FR...

  2. 49 CFR Appendix B to Part 221 - Approved Rear End Marking Devices

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...for or by manufacturers 1. Manufacturer: Star Headlight & Lantern Co., 168 West Main Street...14472. FRA identification Nos. FRA-PLE-STAR-845-F (flasher) and FRA-PLE-STAR-845-C (steady burn). 2....

  3. 49 CFR Appendix B to Part 221 - Approved Rear End Marking Devices

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...for or by manufacturers 1. Manufacturer: Star Headlight & Lantern Co., 168 West Main Street...14472. FRA identification Nos. FRA-PLE-STAR-845-F (flasher) and FRA-PLE-STAR-845-C (steady burn). 2....

  4. 49 CFR Appendix B to Part 221 - Approved Rear End Marking Devices

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...for or by manufacturers 1. Manufacturer: Star Headlight & Lantern Co., 168 West Main Street...14472. FRA identification Nos. FRA-PLE-STAR-845-F (flasher) and FRA-PLE-STAR-845-C (steady burn). 2....

  5. 49 CFR Appendix B to Part 221 - Approved Rear End Marking Devices

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...for or by manufacturers 1. Manufacturer: Star Headlight & Lantern Co., 168 West Main Street...14472. FRA identification Nos. FRA-PLE-STAR-845-F (flasher) and FRA-PLE-STAR-845-C (steady burn). 2....

  6. 49 CFR Appendix B to Part 221 - Approved Rear End Marking Devices

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...for or by manufacturers 1. Manufacturer: Star Headlight & Lantern Co., 168 West Main Street...14472. FRA identification Nos. FRA-PLE-STAR-845-F (flasher) and FRA-PLE-STAR-845-C (steady burn). 2....

  7. 77 FR 53252 - Tier 1 Environmental Impact Statement for the Chicago, IL, to Detroit-Pontiac, MI, Regional...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-31

    ... NEPA and FRA's Procedures for Considering Environmental Impacts (64 FR 28545; May 26, 1999). The Tier 1...). SUMMARY: FRA is issuing this notice of intent (Notice) to advise the public that FRA, with the Michigan... corridor, or a combination of both. FRA is issuing this Notice to solicit public and agency input in...

  8. Cluster of genes that encode positive and negative elements influencing filament length in a heterocyst-forming cyanobacterium.

    PubMed

    Merino-Puerto, Victoria; Herrero, Antonia; Flores, Enrique

    2013-09-01

    The filamentous, heterocyst-forming cyanobacteria perform oxygenic photosynthesis in vegetative cells and nitrogen fixation in heterocysts, and their filaments can be hundreds of cells long. In the model heterocyst-forming cyanobacterium Anabaena sp. strain PCC 7120, the genes in the fraC-fraD-fraE operon are required for filament integrity mainly under conditions of nitrogen deprivation. The fraC operon transcript partially overlaps gene all2395, which lies in the opposite DNA strand and ends 1 bp beyond fraE. Gene all2395 produces transcripts of 1.35 kb (major transcript) and 2.2 kb (minor transcript) that overlap fraE and whose expression is dependent on the N-control transcription factor NtcA. Insertion of a gene cassette containing transcriptional terminators between fraE and all2395 prevented production of the antisense RNAs and resulted in an increased length of the cyanobacterial filaments. Deletion of all2395 resulted in a larger increase of filament length and in impaired growth, mainly under N2-fixing conditions and specifically on solid medium. We denote all2395 the fraF gene, which encodes a protein restricting filament length. A FraF-green fluorescent protein (GFP) fusion protein accumulated significantly in heterocysts. Similar to some heterocyst differentiation-related proteins such as HglK, HetL, and PatL, FraF is a pentapeptide repeat protein. We conclude that the fraC-fraD-fraE?fraF gene cluster (where the arrow indicates a change in orientation), in which cis antisense RNAs are produced, regulates morphology by encoding proteins that influence positively (FraC, FraD, FraE) or negatively (FraF) the length of the filament mainly under conditions of nitrogen deprivation. This gene cluster is often conserved in heterocyst-forming cyanobacteria. PMID:23813733

  9. Cluster of Genes That Encode Positive and Negative Elements Influencing Filament Length in a Heterocyst-Forming Cyanobacterium

    PubMed Central

    Merino-Puerto, Victoria; Herrero, Antonia

    2013-01-01

    The filamentous, heterocyst-forming cyanobacteria perform oxygenic photosynthesis in vegetative cells and nitrogen fixation in heterocysts, and their filaments can be hundreds of cells long. In the model heterocyst-forming cyanobacterium Anabaena sp. strain PCC 7120, the genes in the fraC-fraD-fraE operon are required for filament integrity mainly under conditions of nitrogen deprivation. The fraC operon transcript partially overlaps gene all2395, which lies in the opposite DNA strand and ends 1 bp beyond fraE. Gene all2395 produces transcripts of 1.35 kb (major transcript) and 2.2 kb (minor transcript) that overlap fraE and whose expression is dependent on the N-control transcription factor NtcA. Insertion of a gene cassette containing transcriptional terminators between fraE and all2395 prevented production of the antisense RNAs and resulted in an increased length of the cyanobacterial filaments. Deletion of all2395 resulted in a larger increase of filament length and in impaired growth, mainly under N2-fixing conditions and specifically on solid medium. We denote all2395 the fraF gene, which encodes a protein restricting filament length. A FraF-green fluorescent protein (GFP) fusion protein accumulated significantly in heterocysts. Similar to some heterocyst differentiation-related proteins such as HglK, HetL, and PatL, FraF is a pentapeptide repeat protein. We conclude that the fraC-fraD-fraE?fraF gene cluster (where the arrow indicates a change in orientation), in which cis antisense RNAs are produced, regulates morphology by encoding proteins that influence positively (FraC, FraD, FraE) or negatively (FraF) the length of the filament mainly under conditions of nitrogen deprivation. This gene cluster is often conserved in heterocyst-forming cyanobacteria. PMID:23813733

  10. 77 FR 77181 - Proposed Agency Information Collection Activities; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-31

    .... Form Number(s): FRA F 680.158. Affected Public: Railroad Employees. Respondent Universe: 11,000... Average Time annual CFR section universe responses per response burden hours -------- Form FRA F...

  11. 78 FR 76191 - Operational Tests and Inspections for Compliance With Maximum Authorized Train Speeds and Other...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-16

    ... Train Speeds and Other Speed Restrictions AGENCY: Federal Railroad Administration (FRA), Department of... maximum authorized train speeds and other speed restrictions. SUMMARY: FRA is issuing Safety Advisory 2013... and applicable railroad operating rules regarding maximum authorized train speed limits and...

  12. 49 CFR Appendix C to Part 240 - Procedures for Obtaining and Evaluating Motor Vehicle Driving Record Data

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...privileges, FRA places responsibility on individuals...voluntary State/Federal cooperative program that...color of eyes, and social security account number...such as the person's Social Security account...record. FRA places responsibility on the...

  13. 49 CFR 229.125 - Headlights and auxiliary lights.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... horizontally parallel to the longitudinal centerline of the locomotive or aimed to cross no less than 400 feet... disapproved for a stated cause by FRA's Associate Administrator for Safety or any one of FRA's...

  14. 49 CFR 236.110 - Results of tests.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...otherwise noted, filed in the office of a supervisory official having jurisdiction; and (3) Available for inspection and replication by FRA and FRA-certified State inspectors. (b) Results of tests made in compliance with § 236.587 must be...

  15. 49 CFR 236.110 - Results of tests.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...otherwise noted, filed in the office of a supervisory official having jurisdiction; and (3) Available for inspection and replication by FRA and FRA-certified State inspectors. (b) Results of tests made in compliance with § 236.587 must be...

  16. 49 CFR 236.110 - Results of tests.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...otherwise noted, filed in the office of a supervisory official having jurisdiction; and (3) Available for inspection and replication by FRA and FRA-certified State inspectors. (b) Results of tests made in compliance with § 236.587 must be...

  17. 49 CFR 236.110 - Results of tests.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...otherwise noted, filed in the office of a supervisory official having jurisdiction; and (3) Available for inspection and replication by FRA and FRA-certified State inspectors. (b) Results of tests made in compliance with § 236.587 must be...

  18. 49 CFR 236.110 - Results of tests.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...otherwise noted, filed in the office of a supervisory official having jurisdiction; and (3) Available for inspection and replication by FRA and FRA-certified State inspectors. (b) Results of tests made in compliance with § 236.587 must be...

  19. 78 FR 65422 - Notice of Funding Availability and Solicitation of Applications for Grants Under the Railroad...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-31

    ... Procedures for Considering Environmental Impacts (64 FR 28545) (May 26, 1999) ( http://www.fra.dot.gov/Page...-free workplace, FRA's and OMB's Assurances and Certifications, Americans with Disabilities Act...

  20. 78 FR 78486 - Notice of Funding Availability for Resilience Projects in Response to Hurricane Sandy

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-26

    ...transferred $185 million to the Federal Railroad Administration (FRA). The Moving Ahead...passenger rail projects to the Federal Railroad Administration (FRA). II. Public...prevent the intrusion of floodwaters into underground segments of a public transportation...

  1. 78 FR 1604 - Department Regulatory Agenda; Semiannual Summary

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-08

    ...the beginning of PATT in 1985. Currently, FRA tests blood and urine specimens for eight drug classifications: alcohol, marijuana, cocaine, the opiates, the amphetamines, phencyclidine (PCP), the barbiturates, and the benzodiazepines. FRA...

  2. 49 CFR Appendix A to Part 222 - Approved Supplementary Safety Measures

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...Zones.) Effectiveness: 1.0. Because an effective...traffic. Effectiveness: 1.0. Required: a. The...See appendix D. FRA's web-based Quiet Zone Calculator...See appendix D. FRA's web-based Quiet Zone...

  3. 77 FR 75699 - Petition for Waiver of Compliance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-21

    ... end-facing glazing locations of the locomotive cab windshield as well as FRA Type II material in all... retrofitting the locomotive with FRA-certified glazing. RSSX intends to install hurricane and/or safety...

  4. 78 FR 16051 - Vehicle/Track Interaction Safety Standards; High-Speed and High Cant Deficiency Operations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-13

    ... vehicle/track interaction safety, see 75 FR 25928, FRA issues this final rule amending the Track Safety... granted to FRA comprehensive authority over ``all areas of railroad safety.'' See 36 FR 20336. FRA... 22, 1998, see 63 FR 33992, which, effective September 21, 1998, revised the Track Safety Standards...

  5. 75 FR 82136 - Adjustment of Nationwide Significant Risk Threshold

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-29

    ... Locomotive Horns at Highway-Rail Grade Crossings,'' was amended, the NSRT was 17,030 (71 FR 47614, August 17, 2006). In 2007, FRA recalculated the NSRT to be 19,047 (72 FR 14850, March 29, 2007). In 2008, FRA recalculated the NSRT to be 17,610 (73 FR 30661, May 28, 2008). In 2009, FRA recalculated the NSRT to be...

  6. 77 FR 546 - Adjustment of Nationwide Significant Risk Threshold

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-05

    ... Locomotive Horns at Highway-Rail Grade Crossings,'' was amended, the NSRT was 17,030 (71 FR 47614, August 17, 2006). In 2007, FRA recalculated the NSRT to be 19,047 (72 FR 14850, March 29, 2007). In 2008, FRA recalculated the NSRT to be 17,610 (73 FR 30661, May 28, 2008). In 2009, FRA recalculated the NSRT to be...

  7. 75 FR 4703 - Track Safety Standards; Continuous Welded Rail (CWR)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-29

    ...No. FRA-2008-0036] RIN 2130-AB90 Track Safety Standards; Continuous Welded Rail...on August 25, 2009, which revised the Track Safety Standards. FRA received one petition...FRA published a final rule revising the Track Safety Standards on August 25,...

  8. 78 FR 28284 - Petition for Waiver of Compliance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-14

    ...'s complete Privacy Act Statement in the Federal Register published on April 11, 2000 (65 FR 19477... April 11, 2013, Canadian Pacific Railway (CP) has petitioned the Federal Railroad Administration (FRA... Equipment; End-of-Train Devices. FRA assigned the petition Docket Number FRA-2013-0040. Specifically,...

  9. 77 FR 43646 - Petition for Waiver of Compliance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-25

    ... February 28, 2012, Canadian Pacific Railway (CP) has petitioned the Federal Railroad Administration (FRA... System (C3RS) pilot project for the CP Portage, WI, terminal was initially approved by FRA on March 3, 2008. In Docket Number FRA-2007-0008, CP requested and received a waiver of compliance from...

  10. 76 FR 34801 - Petition for Modification of Single Car Air Brake Test Procedures

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-14

    ...FRA-2010-0174] Petition for Modification of Single Car Air Brake Test Procedures In accordance...FRA) grant a modification of the single car air brake test procedures as prescribed...FRA-2010-0174. PATH operates a fleet of 25 flat cars in consist with revenue cars utilized...

  11. 78 FR 71785 - Passenger Train Emergency Systems II

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-29

    ... FRA's January 3, 2012, proposed rule on passenger train emergency systems, see 77 FR 153, FRA issues... the Act, FRA published the Passenger Train Emergency Preparedness (PTEP) final rule. See 63 FR 24629...) final rule. See 64 FR 25540. The rule established comprehensive safety standards for railroad...

  12. 49 CFR 262.15 - Environmental assessment.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Environmental Quality (40 CFR part 1500) and the Advisory Council on Historic Preservation Protection of Historic Properties regulation (36 CFR part 800) will govern FRA's compliance with applicable environmental... FRA to approve a project for physical construction. FRA's “Procedures for Considering...

  13. FOS-like antigen 1 is highly expressed in human psoriasis tissues and promotes the growth of HaCaT cells in vitro.

    PubMed

    Zhu, Wu; Li, Jing; Su, Juan; Li, Jie; Li, Jinmao; Deng, Bo; Shi, Qian; Zhou, Yanhong; Chen, Xiang

    2014-11-01

    Psoriasis is a multifactorial disease and the mechanisms involved in its pathogenesis remain to be elucidated. FOS?like antigen 1 (Fra?1) is a proto?oncogene. It is a negative inhibitor of activator protein?1 activity and possesses transforming activity. The effect of and possible mechanisms underlying Fra?1 in psoriasis remain to be elucidated. In the present study, western blot analysis and reverse transcription?quantitative polymerase chain reaction (RT?qPCR) techniques were used to identify differentially expressed Fra?1 in psoriatic and in normal control tissues. Compared with the control samples, the expression of normalized Fra?1 genes in psoriasis was 12.6 times higher. Western blot analysis was used to assess the protein levels of Fra?1. The results demonstrated that the protein expression of Fra-1 was high in tissues affected by psoriasis. This also corresponded with the results of RT?qPCR. Fra?1?stable expressing HaCaT/Fra?1 or control HaCaT/vector cell lines were then generated to elucidate the function of Fra?1 in the growth of HaCaT cells. The results demonstrated that Fra?1 promoted the growth of HaCaT cells in vitro by arresting the cell cycle and inhibiting cell apoptosis. These results suggested that Fra?1 may be important in psoriasis. PMID:25175497

  14. 78 FR 70623 - Adjustment of Nationwide Significant Risk Threshold

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-26

    ... calculated to be 17,030 (71 FR 47614, August 17, 2006). In 2007, FRA recalculated the NSRT to be 19,047 (72 FR 14850, March 29, 2007). In 2008, FRA recalculated the NSRT to be 17,610 (73 FR 30661, May 28, 2008). In 2009, FRA recalculated the NSRT to be 18,775 (74 FR 45270, September 1, 2009). In 2010,...

  15. 75 FR 31834 - Adoption of Environmental Impact Statement; Availability of an Environmental Reevaluation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-04

    ...Reevaluation AGENCY: Federal Railroad Administration (FRA), Department of Transportation (DOT). ACTION: Adoption and Recirculation of Final Environmental Impact Statement and Notice of Availability of Environmental...

  16. 78 FR 13747 - Railroad Safety: Advisory Notice Related to Railroad Accidents in Vicinity of Underground Pipelines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-28

    ...DEPARTMENT OF TRANSPORTATION Federal Railroad Administration Railroad Safety: Advisory Notice Related to Railroad Accidents in Vicinity of Underground Pipelines AGENCY: Federal Railroad Administration (FRA), Department of Transportation...

  17. BRICS'2001 Lecture 2 Tools to show nondefinability

    E-print Network

    Makowsky, Johann A. "Janos"

    BRICS'2001 Lecture 2 Lecture 2 Tools to show non­definability ffl Ehrenfeucht­Fra¨iss'e games ffl ffl Definability of Hamiltonicity and Eulerian graphs 1 BRICS'2001 Lecture 2 Ehrenfeucht­Fra ¨ iss­move) or in A ff (point move). II puts corresponding pebble on set or point. 2 BRICS'2001 Lecture 2 Ehrenfeucht

  18. 78 FR 77601 - Adjustment of Monetary Threshold for Reporting Rail Equipment Accidents/Incidents for Calendar...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-24

    ... 61 FR 60632 (Nov. 29, 1996). In 2005, FRA again amended its method for calculating the reporting... Surface Transportation Board for the BLS data that was no longer collected (70 FR 75414 (Dec. 20, 2005... threshold was revised. 77 FR 71354 (November 30, 2012). Consequently, FRA has recalculated the threshold,...

  19. 75 FR 75911 - Adjustment of Monetary Threshold for Reporting Rail Equipment Accidents/Incidents for Calendar...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-07

    ... reporting threshold was revised. 74 FR 65458 (December 10, 2009). Consequently, FRA has recalculated the... final rule published December 20, 2005, 70 FR 75414. FRA has found that both the current cost data... both Executive Order 12866 and DOT policies and procedures (44 FR 11034 (Feb. 26, 1979))....

  20. 77 FR 71354 - Adjustment of Monetary Threshold for Reporting Rail Equipment Accidents/Incidents for Calendar...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-30

    ... reporting threshold was revised. 76 FR 72850 (November 28, 2011). Consequently, FRA has recalculated the... final rule published December 20, 2005, 70 FR 75414. FRA has found that both the current cost data... 12866 and 13563 in addition to DOT policies and procedures (44 FR 11034 (Feb. 26, 1979))....

  1. 76 FR 72850 - Adjustment of Monetary Threshold for Reporting Rail Equipment Accidents/Incidents for Calendar...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-28

    ... reporting threshold was revised. 75 FR 75911 (December 7, 2010). Consequently, FRA has recalculated the... published December 20, 2005, 70 FR 75414. FRA has found that both the current cost data inserted into this... addition to DOT policies and procedures (44 FR 11034 (Feb. 26, 1979)). Regulatory Flexibility Act...

  2. 77 FR 64249 - Track Safety Standards; Improving Rail Integrity

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-19

    ... track constructed with concrete crossties. See 76 FR 18073. FRA received two petitions for... railroad safety.'' See 36 FR 20336. FRA envisioned the new Standards to be an evolving set of safety... the Standards in 1998. See 63 FR 34029, June 22, 1998; 63 FR 54078, Oct. 8, 1998. Pursuant to 49...

  3. 77 FR 65935 - Petition for Waiver of Compliance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-31

    ... Federal Railroad Administration Petition for Waiver of Compliance In accordance with Part 211 of Title 49... safety regulations contained in 49 CFR part 230--Steam Locomotive Inspection and Maintenance Standards. FRA assigned the petition Docket Number FRA- 2012-0076. Steam Locomotive Number 2719 is a former...

  4. 76 FR 70532 - Proposed Agency Information Collection Activities; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-14

    In accordance with the Paperwork Reduction Act of 1995 and its implementing regulations, the Federal Railroad Administration (FRA) hereby announces that it is seeking renewal of the following currently approved information collection activities. Before submitting these information collection requirements (ICRs) for clearance by the Office of Management and Budget (OMB), FRA is soliciting public......

  5. 49 CFR 216.11 - Special notice for repairs-railroad freight car.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Special notice for repairs-railroad freight car...—railroad freight car. (a) When an FRA Motive Power and Equipment Inspector or a State Equipment Inspector determines that a railroad freight car is not in conformity with the requirements of the FRA Freight...

  6. Lunar Sample Compendium C Meyer 2011

    E-print Network

    Rathbun, Julie A.

    Lunar Sample Compendium C Meyer 2011 14055 Regolith Breccia 111 grams Figure 1: Photos of 14055 Glass Crystalline-Matrix-Breccias Apollo 14 CMB (Fra Mauro) Regolith breccias Light matrix breccia 14055 14055 Figure 2: Map of Apollo 14 showing location of 14055. Figure 3: 14055 is not a Fra Mauro breccia

  7. The Fragile Fiber1 Kinesin Contributes to Cortical Microtubule-Mediated Trafficking of Cell Wall Components1[OPEN

    PubMed Central

    Zhu, Chuanmei; Ganguly, Anindya; Baskin, Tobias I.; McClosky, Daniel D.; Anderson, Charles T.; Foster, Cliff; Meunier, Kristoffer A.; Okamoto, Ruth; Berg, Howard

    2015-01-01

    The cell wall consists of cellulose microfibrils embedded within a matrix of hemicellulose and pectin. Cellulose microfibrils are synthesized at the plasma membrane, whereas matrix polysaccharides are synthesized in the Golgi apparatus and secreted. The trafficking of vesicles containing cell wall components is thought to depend on actin-myosin. Here, we implicate microtubules in this process through studies of the kinesin-4 family member, Fragile Fiber1 (FRA1). In an fra1-5 knockout mutant, the expansion rate of the inflorescence stem is halved compared with the wild type along with the thickness of both primary and secondary cell walls. Nevertheless, cell walls in fra1-5 have an essentially unaltered composition and ultrastructure. A functional triple green fluorescent protein-tagged FRA1 fusion protein moves processively along cortical microtubules, and its abundance and motile density correlate with growth rate. Motility of FRA1 and cellulose synthase complexes is independent, indicating that FRA1 is not directly involved in cellulose biosynthesis; however, the secretion rate of fucose-alkyne-labeled pectin is greatly decreased in fra1-5, and the mutant has Golgi bodies with fewer cisternae and enlarged vesicles. Based on our results, we propose that FRA1 contributes to cell wall production by transporting Golgi-derived vesicles along cortical microtubules for secretion. PMID:25646318

  8. 77 FR 64183 - Notice of Availability of a Final General Conformity Determination for the California High-Speed...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-18

    ... California High-Speed Train System Merced to Fresno Section AGENCY: Federal Railroad Administration (FRA... Section of the California High-Speed Train (HST) System on September 18, 2012. FRA is the lead Federal... General Conformity requirements. The California High Speed Rail Authority (Authority), as the...

  9. 76 FR 18298 - Notice of Availability of a Final Environmental Impact Statement for the DesertXpress High-Speed...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-01

    ... Considering Environmental Impacts (64 FR 28545, May 26, 1999). The Bureau of Land Management (BLM), Surface... DesertXpress High-Speed Passenger Train Project AGENCY: Federal Railroad Administration (FRA), United... High-Speed Passenger Train Project (DesertXpress project). FRA is the Lead Agency for the...

  10. 77 FR 75896 - Alcohol and Drug Testing: Determination of Minimum Random Testing Rates for 2013

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-26

    ... Federal Railroad Administration 49 CFR Part 219 Alcohol and Drug Testing: Determination of Minimum Random Testing Rates for 2013 AGENCY: Federal Railroad Administration (FRA), DOT. ACTION: Notice of determination. According to data from FRA's Management Information System, the rail industry's random drug testing...

  11. 75 FR 79308 - Alcohol and Drug Testing: Determination of Minimum Random Testing Rates for 2011

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-20

    ... Drug and Alcohol Testing Rates In a final rule published on December 2, 1994 (59 FR 62218), FRA... Federal Railroad Administration 49 CFR Part 219 Alcohol and Drug Testing: Determination of Minimum Random Testing Rates for 2011 AGENCY: Federal Railroad Administration (FRA), DOT. ACTION: Notice of...

  12. 76 FR 67020 - Railroad Safety Advisory Committee; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-28

    ...FRA announces the forty-fifth meeting of the RSAC, a Federal Advisory Committee that develops railroad safety regulations through a consensus process. The RSAC meeting topics will include opening remarks from the FRA Administrator, and status reports will be provided by the Electronic Device Distraction, Critical Incident, Track Safety Standards, Dark Territory, Passenger Safety, and Medical......

  13. 77 FR 19054 - Railroad Safety Advisory Committee; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-29

    ...FRA announces the forty-sixth meeting of the RSAC, a Federal Advisory Committee that develops railroad safety regulations through a consensus process. The RSAC meeting topics will include opening remarks from the FRA Administrator, and status reports will be provided by the Track Safety Standards, Critical Incident, Dark Territory, Fatigue Management, Risk Reduction, Electronic Device......

  14. 77 FR 24415 - Inflation Adjustment of the Aggravated Maximum Civil Monetary Penalty for a Violation of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-24

    ... $650, the ordinary maximum of $25,000, and the aggravated maximum CMP of $100,000). See 73 FR 79698...-adjusted $550. 69 FR 30591 (May 28, 2004) and 69 FR 62817 (Oct. 28, 2004). (In 2004, FRA had determined, by... should be increased to $650. 73 FR 79698 (Dec. 30, 2008). In 2009, FRA also published a...

  15. 75 FR 43840 - Inflation Adjustment of the Ordinary Maximum and Aggravated Maximum Civil Monetary Penalties for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-27

    ... civil monetary penalties per the Inflation Act. See 74 FR 68701 (December 29, 2009). FRA's maximum and... materials violation was $275. 69 FR 30590, May 28, 2004. To implement these SAFETEA-LU amendments to the maximum and minimum penalties, FRA issued a final rule that was published on December 26, 2006, 71...

  16. 49 CFR Appendix C to Part 218 - Statement of Agency Enforcement Policy on Tampering

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... similar contexts. (See 49 CFR 107.299, defining “knowingly” under the Hazardous Materials Transportation... operating. Also, unlike the case where willfulness must be shown (see FRA's statement of policy at 49 CFR... currently undergoing research testing. FRA has been advised by portions of the regulated community that...

  17. 49 CFR Appendix C to Part 218 - Statement of Agency Enforcement Policy on Tampering

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... similar contexts. (See 49 CFR 107.299, defining “knowingly” under the Hazardous Materials Transportation... operating. Also, unlike the case where willfulness must be shown (see FRA's statement of policy at 49 CFR... currently undergoing research testing. FRA has been advised by portions of the regulated community that...

  18. 78 FR 78275 - Alcohol and Drug Testing: Determination of Minimum Random Testing Rates for 2014

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-26

    ...According to data from FRA's Management Information System, the rail industry's random drug testing positive rate has remained below 1.0 percent for the last two years. FRA's Administrator has therefore determined that the minimum annual random drug testing rate for the period January 1, 2014, through December 31, 2014, will remain at 25 percent of covered railroad employees. In addition,......

  19. 75 FR 36551 - State Highway-Rail Grade Crossing Action Plans

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-28

    ... Action Plans as a direct final rule in the Federal Register on September 2, 2009 (74 FR 45336). FRA... requested that FRA provide guidance or otherwise clarify whether two particular rail systems were exempt... jurisdiction determinations regarding particular rail systems. Such jurisdiction determinations are...

  20. 78 FR 59754 - Notice of Application for Approval of Railroad Safety Program Plan and Product Safety Plan

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-27

    ... System. FRA assigned the petition Docket Number FRA-2013-0088. The TrackAccess System is a processor-based dispatch system developed to be operated in autonomous mode (without dispatcher intervention) for low-density rail lines. The system provides a processor-based methodology of requesting and...

  1. 6 lrdag 10. november 2012| Nyheter | Ungdommen p Toten legger ikke skjul

    E-print Network

    Tufto, Jarle

    . Risikoen for å dø i trafikken er fem ganger høyere på bygda enn i byen, viser forskning. Høy fart på bygda vinterluften med mu- sikk fra anlegg som er mer verdt enn bilene, eksos fra rør preget av god fart over

  2. 78 FR 38878 - Critical Incident Stress Plans

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-28

    ... report prepared by FRA grantee, Dr. Richard Gist, in support of Grant FR-RRD-0024-11- 01, titled... Administrator of FRA on rulemakings and other safety program issues. 61 FR 9740 (Mar. 11, 1996). RSAC's charter under the Federal Advisory Committee Act (Pub. L. 92-463) was most recently renewed in 2012. 77 FR...

  3. 77 FR 21311 - Locomotive Safety Standards

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-09

    ..., inspection, testing, and repair requirements. FRA's Remote Control Locomotive Safety Advisory, published in... of study and testing. Over the last several decades, FRA has granted several conditional waivers... extensions were designed to accommodate testing of the reliability of electronic brake systems and...

  4. 77 FR 75698 - Petition for Waiver of Compliance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-21

    ... August 28, 2012, the North Coast Line, Inc. (NCL) of Doylestown, OH, has petitioned the Federal Railroad...). FRA assigned the petition Docket Number FRA-2012-0078. NCL has petitioned for a permanent waiver of... windows are \\1/4\\-inch panes of GE Marguard/Lexan. NCL states that there has been no accident or...

  5. 78 FR 56995 - Proposed Agency Information Collection Activities; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-16

    ...In accordance with the Paperwork Reduction Act of 1995 and its implementing regulations, the Federal Railroad Administration (FRA) hereby announces that it is seeking renewal of the following currently approved information collection activities. Before submitting these information collection requirements for clearance by the Office of Management and Budget (OMB), FRA is soliciting public......

  6. 75 FR 68021 - Draft Finding of No Significant Impact on the Tier 1 Ohio 3C Quick Start Passenger Rail Tier-1...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-04

    ... Federal Railroad Administration Draft Finding of No Significant Impact on the Tier 1 Ohio 3C Quick Start... FR 28545, May 26, 1999), the FRA and the Ohio Department of Transportation (ODOT) and the Ohio Rail... impacts of the 3C Quick Start Passenger Rail Project. Based on the Tier-1 EA, the FRA has prepared a...

  7. 76 FR 2199 - Locomotive Safety Standards

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-12

    ... October 19, 2007 (72 FR 59216). FRA continued to utilize the RSAC process to address additional locomotive... locomotive operations. See 66 FR 10340, Notice of Safety Advisory 2001-01, Docket No. FRA-2000-7325. By... awareness. See 71 FR 60372 (2006). During several productive meetings, the Working Group identified...

  8. 77 FR 52393 - Railroad Safety Advisory Committee; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-29

    ...FRA announces the forty-seventh meeting of the RSAC, a Federal Advisory Committee that develops railroad safety regulations through a consensus process. The RSAC meeting topics will include opening remarks from the FRA Administrator, and status reports will be provided by the Critical Incident, Fatigue Management, and Risk Reduction Working Groups. Status reports will also be provided by the......

  9. 49 CFR Appendix C to Part 236 - Safety Assurance Criteria and Processes

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...standards are shown to achieve the requirements of this part. However, any such standards shall be available for inspection and replication by FRA and for public examination in any public proceeding before the FRA to which they are relevant. (5) The...

  10. 49 CFR Appendix C to Part 236 - Safety Assurance Criteria and Processes

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...standards are shown to achieve the requirements of this part. However, any such standards shall be available for inspection and replication by FRA and for public examination in any public proceeding before the FRA to which they are relevant. (5) The...

  11. 49 CFR Appendix C to Part 236 - Safety Assurance Criteria and Processes

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...standards are shown to achieve the requirements of this part. However, any such standards shall be available for inspection and replication by FRA and for public examination in any public proceeding before the FRA to which they are relevant. (5) The...

  12. 49 CFR Appendix C to Part 236 - Safety Assurance Criteria and Processes

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...standards are shown to achieve the requirements of this part. However, any such standards shall be available for inspection and replication by FRA and for public examination in any public proceeding before the FRA to which they are relevant. (5) The...

  13. 77 FR 37737 - Environmental Impact Statement for the Northeast Corridor Between Washington, DC, New York, NY...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-22

    ...FRA is issuing this Notice of Intent (Notice) to advise the public of the preparation of a Tier 1 Environmental Impact Statement (EIS) to evaluate potential passenger rail improvements between Washington, DC, New York City, and Boston, MA. FRA is leading the planning and environmental evaluation of the Northeast Corridor (NEC), an effort known as NEC FUTURE, in close coordination with the......

  14. 77 FR 6411 - Training, Qualification, and Oversight for Safety-Related Railroad Employees

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-07

    ...FRA proposes regulations establishing minimum training standards for each category and subcategory of safety-related railroad employee, as required by the Rail Safety Improvement Act of 2008. The proposed rule would require each railroad or contractor that employs one or more safety-related railroad employee to develop and submit a training program to FRA for approval and to designate the......

  15. 77 FR 48591 - State Rail Plan Guidance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-14

    ...FRA is publishing this notice to request comments on FRA's technical guidance for the development, submission, and acceptance of State rail plans. State rail plans are documents that are required under Section 303 of the Passenger Rail Investment and Improvement Act of 2008 (Pub. L. 110-432). Section 303 of PRIIA provides for enhanced State involvement in rail policy, planning, and development......

  16. 78 FR 28284 - Petition for Waiver of Compliance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-14

    ...April 11, 2013, Canadian Pacific Railway (CP) has petitioned the Federal Railroad Administration...Number FRA-2013-0040. Specifically, CP requests relief from 49 CFR 232.205...operating in distributive power (DP) mode. CP requests that FRA allow 90 cubic feet...

  17. 75 FR 65398 - Petition for Waiver of Compliance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-22

    ...FRA-2010-0024] The Canadian Pacific Railway (CP) hereby petitions FRA for a temporary waiver...measurement system. Over the course of 6 months, CP intends to test the new system on their...a frequency that is not possible today. CP asserts that the benefits that are...

  18. 78 FR 9107 - Petition for Waiver of Compliance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-07

    ... (65 FR 19477). Issued in Washington, DC, on February 4, 2013. Robert C. Lauby, Deputy Associate... September 25, 2012, the Kiski Junction Railroad (KJR) has petitioned the Federal Railroad Administration... assigned the petition Docket Number FRA-2012-0081. KJR has petitioned FRA for a waiver to operate...

  19. 49 CFR 209.105 - Notice of probable violation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...FRA may change the civil penalty amount proposed to be assessed up to and including the maximum penalty amount of $55,000 for each...if the violation results in death, serious illness or severe...property, FRA may change the penalty amount proposed to be...

  20. 49 CFR 209.105 - Notice of probable violation.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...FRA may change the civil penalty amount proposed to be assessed up to and including the maximum penalty amount of $55,000 for each...if the violation results in death, serious illness or severe...property, FRA may change the penalty amount proposed to be...

  1. 49 CFR 209.105 - Notice of probable violation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...FRA may change the civil penalty amount proposed to be assessed up to and including the maximum penalty amount of $75,000 for each...if the violation results in death, serious illness or severe...property, FRA may change the penalty amount proposed to be...

  2. 49 CFR 209.105 - Notice of probable violation.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...FRA may change the civil penalty amount proposed to be assessed up to and including the maximum penalty amount of $75,000 for each...if the violation results in death, serious illness or severe...property, FRA may change the penalty amount proposed to be...

  3. 49 CFR 209.105 - Notice of probable violation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...FRA may change the civil penalty amount proposed to be assessed up to and including the maximum penalty amount of $55,000 for each...if the violation results in death, serious illness or severe...property, FRA may change the penalty amount proposed to be...

  4. 78 FR 48218 - Emergency Order Establishing Additional Requirements for Attendance and Securement of Certain...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-07

    ... Terminal The Federal Railroad Administration (FRA) of the United States Department of Transportation (DOT... terminal are properly secured against unintended movement. FRA re-examined its regulations governing the... mainline track or mainline siding outside of a yard or terminal to ensure ] the safe transportation by...

  5. 77 FR 22381 - Odorant Fade in Railroad Tank Cars

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-13

    ...FRA is issuing Safety Advisory 2012-01 to remind shippers and consignees of railroad tank cars containing odorized liquefied petroleum gas (LPG), of the importance of taking actions to ensure that a sufficient level of odorant remains in the LPG throughout the entire transportation cycle. FRA is issuing this notice to raise awareness within the hazardous materials community, of the potential......

  6. 76 FR 55819 - Track Safety Standards; Concrete Crossties

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-09

    ..., FRA delayed the effective date of the final rule until October 1, 2011. See 76 FR 34,890 (June 15... 403(d), of the Rail Safety Improvement Act of 2008 (Pub. L. 110-432, Division A) (RSIA). See 75 FR 52... concrete crossties. See 76 FR 18,073. FRA received two petitions for reconsideration in response to...

  7. 78 FR 36738 - Signal System Reporting Requirements

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-19

    ... modernize our regulatory system and to reduce unjustified regulatory burdens and costs.'' See 77 FR 28469... annually. See 61 FR 33871 (July 1, 1996). FRA determined that a five-year reporting period would...). In 1984, FRA amended its Signal and Train Control Regulations, including 49 CFR Part 233. See 49...

  8. 77 FR 50323 - Railroad Workplace Safety; Roadway Worker Protection Miscellaneous Revisions (RRR)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-20

    ... hazards faced by roadway workers. 57 FR 54038. ] FRA held workshops to solicit the views of the railroad... regulatory negotiation. 59 FR 42200. The FAC was tasked with submitting a report, including proposed... as the basis for FRA's first RWP NPRM, which was published on March 14, 1996. 61 FR 10528....

  9. 75 FR 2466 - State Highway-Rail Grade Crossing Action Plans

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-15

    ...hearing should notify the FRA's Docket Clerk by mail, Michelle Silva, Office of Chief Counsel, FRA, 1200 New Jersey Ave. SE., Room W31-109, Washington, DC 20590, or e-mail (Michelle.Silva@dot.gov), or at the fax number 202- 493-6068, at...

  10. 49 CFR 1106.4 - The Safety Integration Plan process.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... at 49 CFR part 244, or other FRA guidelines or requirements regarding the contents of a SIP, with SEA... ongoing environmental review process under 49 CFR part 1105. The procedures governing the process shall be as follows: (1) In accordance with 49 CFR 244.17, FRA will provide its findings and conclusions...

  11. Politecnico di Milano Facolt di Ingegneria Industriale

    E-print Network

    Amigoni, Francesco

    a video, in ordine inverso, solo i numeri dispari della sequenza. #include #define N 500 */ /* compreso fra 0 e 100 */ /* stampa i numeri dispari in ordine inverso */ for(i=N-1; i>=0; i--) if(seq[i]%2 */ /* compreso fra 0 e 100 */ i++; }while(iinverso */ i=N-1; do{ if

  12. 76 FR 414 - Tier 1 Environmental Impact Statement for the Los Angeles to San Luis Obispo (LOSSAN North) Rail...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-04

    ...), Division 13, Public Resources Code; and FRA's Procedures for Considering Environmental Impacts (64 FR 28545...-654-7184) or Ms. Melissa Elefante DuMond, Environmental Protection Specialist, Office of Railroad...Mond at the FRA address identified above. Comments may also be addressed to Ms. Lea Simpson of...

  13. 75 FR 74131 - Notice of Finding of No Significant Impact for the Washington State Portion of the Pacific...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-30

    ... Procedures for Considering Environmental Impacts (FRA Environmental Procedures) (64 FR 28545 (May 26, 1999... procedures for obtaining funding under the HSIPR Program (74 FR 29901 (June 23, 2009)), WSDOT prepared a Tier... calendar days (75 FR 39325 (July 8, 2010)). FRA received six comments on the draft FONSI,...

  14. 78 FR 2713 - Update to NEPA Implementing Procedures

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-14

    ... Environmental Impacts (FRA Environmental Procedures), 64 FR 28545 (May 26, 1999), which are available on the... appropriated additional funds for HSIPR projects in the Transportation, Housing and Urban Development and... June 13, 2012, FRA published a notice in the Federal Register (77 FR 35471) advising the public of...

  15. 78 FR 23631 - Notice of Intent To Grant Buy America Waiver to Amtrak To Use Three Non-Domestic Component Parts...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-19

    ...also requested a waiver for the Turnout's vee point. However, FRA determined that a waiver is not necessary with regard to the vee point. FRA considers manufactured goods...Page/P0391 (FAQ no. 6). Because the vee point is a subcomponent of one of the...

  16. 77 FR 29307 - Control of Alcohol and Drug Use: Addition of Post-Accident Toxicological Testing for Non...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-17

    ... accidents (50 FR 31508, August 2, 1985). If an accident meets FRA's criteria for post-accident testing (see... prescription and OTC drug use by their safety-sensitive employees. See 63 FR 71334, December 24, 1998. After... Order 12866 and 13563 and DOT policies and procedures. See 44 FR 11034; February 26, 1979. FRA...

  17. 49 CFR Appendix A to Part 231 - Schedule of Civil Penalties 1

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... where circumstances warrant. See 49 CFR part 209, appendix A. 2 This schedule uses section numbers from FRA's Safety Appliance Defect Code, a restatement of the CFR text in a reorganized format. For... than the CFR. FRA reserves the right, should litigation become necessary, to substitute in...

  18. 49 CFR Appendix A to Part 231 - Schedule of Civil Penalties 1

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... where circumstances warrant. See 49 CFR part 209, appendix A. 2 This schedule uses section numbers from FRA's Safety Appliance Defect Code, a restatement of the CFR text in a reorganized format. For... than the CFR. FRA reserves the right, should litigation become necessary, to substitute in...

  19. 49 CFR Appendix A to Part 231 - Schedule of Civil Penalties 1

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... where circumstances warrant. See 49 CFR part 209, appendix A. 2 This schedule uses section numbers from FRA's Safety Appliance Defect Code, a restatement of the CFR text in a reorganized format. For... than the CFR. FRA reserves the right, should litigation become necessary, to substitute in...

  20. 77 FR 60169 - Safety Advisory 2012-04; Worn Rail Conditions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-02

    ... nondestructive rail inspection at this location. FRA believes that this accelerated defect development was... the rate of defect development, which typically results in testing for internal defects at a frequency shorter than required by FRA regulation. Yet, a nondestructive test system is typically designed...

  1. Personal independence of adult mentally retarded men with fragile-X syndrome.

    PubMed

    Maes, B; Fryns, J P; Van Walleghem, M; Van den Berghe, H

    1994-01-01

    In a large study of the psychosocial functioning of mentally retarded adults with fra(X) syndrome we also evaluated their personal independence. 58 mentally retarded adult men with a cytogenetically confirmed diagnosis of fra(X) syndrome and 58 fra(X) negative control persons with a comparable age, level of cognitive development, actual living conditions and length of institutionalization were evaluated with three Dutch standardized behavioral scales. In spite of comparable social competency scores in both research groups, two significant different aspects were found: 1) Fra(X) men obtained a higher level of elementary knowledge and skillfulness in rudimentary dealing with personal needs and household tasks in daily life in comparison with the control group; 2) moderately mentally retarded fra(X) adults were practising more preacademic reading, calculating and writing skills in daily life than control persons. PMID:7917120

  2. Cognitive functioning and information processing of adult mentally retarded men with fragile-X syndrome.

    PubMed

    Maes, B; Fryns, J P; Van Walleghem, M; Van den Berghe, H

    1994-04-01

    The present study describes cognitive skills and information processing strategies of mentally retarded fra(X) men. Fifty-eight fra(X) positive and 58 fra(X) negative adults, matched on sex, chronological age, length of institutionalisation, general cognitive level, and living conditions, were evaluated with the Bayley or McCarthy Scales of Mental Abilities. Mental ages were mostly situated in the severe mental handicap category and were found to be negatively influenced by chronological age. A relative strength in perceptual performance and non-verbal reasoning and a deficit in sequential information processing turned out to be typical of all mentally retarded subjects, irrespective of fra(X) or control status. Fra(X) adults could be significantly differentiated from control persons on the ground of a higher level of acquired knowledge because of better vocabulary and verbal-expressive skills. On the other hand, they were less able to imitate non-verbal patterns, had more difficulty with visual-motor integration and co-ordination, and applied less efficient general mental processing skills in solving new problems. The memory profile of fra(X) adults was strongly determined by the meaning and the complexity of the information that has to be reproduced. In this article the profile of cognitive strengths and weaknesses in the fra(X) group will be discussed and some general advice for training is suggested. PMID:8010351

  3. 77 FR 45715 - Notice of Public Hearing: Reading Blue Mountain and Northern Railroad

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-01

    ...Federal Railroad Administration [Docket Number FRA-2003-15754] Notice of Public Hearing: Reading Blue Mountain and Northern Railroad The Reading Blue Mountain and Northern Railroad (RBMN) has petitioned the Federal Railroad...

  4. 78 FR 76190 - Proposed Agency Information Collection Activities; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-16

    ... Federal Railroad Administration Proposed Agency Information Collection Activities; Comment Request AGENCY... of the following currently approved information collection activities. Before submitting these information collection requirements for clearance by the Office of Management and Budget (OMB), FRA...

  5. 78 FR 77553 - Proposed Agency Information Collection Activities; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-23

    ... Federal Railroad Administration Proposed Agency Information Collection Activities; Comment Request AGENCY... of the following currently approved information collection activities. Before submitting these information collection requirements for clearance by the Office of Management and Budget (OMB), FRA...

  6. 78 FR 42998 - Hazardous Materials: Improving the Safety of Railroad Transportation of Hazardous Materials

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-18

    ...Safety of Railroad Transportation of Hazardous Materials AGENCY: Pipeline...meeting addressing the transportation of hazardous materials by rail. FRA and...q). The Federal hazardous materials transportation laws, 49...

  7. 76 FR 30855 - Accident/Incident Reporting Requirements

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-27

    ...rule, the supplemental code and its narrative varied throughout Appendix J to the FRA...Other Than Main Track Z--Other-Narrative Required 5. Appendix...or regulation, including notices of inquiry, advance notices of proposed...

  8. Privatarkiv nr. 99 Finne-familien, Trondheim

    E-print Network

    Tufto, Jarle

    , Emilie f. Falsen Finne, Hans Wingård Finne, Hilmar Meincke Finne, Hilmar Meincke (tannlege) Finne, Johan fra Paris i des. 1870 til H. W. Finne & Sønner 1 regnskapsbok for Emilie Finne 1 eldre fransk

  9. 49 CFR 240.5 - Preemptive effect and construction.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Government; and does not impose an unreasonable burden on interstate commerce. (b) FRA does not intend by... and customary manner, including those contained in its collective bargaining agreements. (e)...

  10. 78 FR 42998 - Hazardous Materials: Improving the Safety of Railroad Transportation of Hazardous Materials

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-18

    ... TRANSPORTATION Federal Railroad Administration Hazardous Materials: Improving the Safety of Railroad Transportation of Hazardous Materials AGENCY: Pipeline and Hazardous Materials, Safety Administration (PHMSA... participate in a public meeting addressing the transportation of hazardous materials by rail. FRA and...

  11. Erhvervssamarbejde et her kan blive interessant. Sdan tnkte lektor Jesper

    E-print Network

    Nygård, Jesper

    kolleger fra Niels Bohr Institutet ef- ter års forskning fik kombineret uhyre små kulstofnanorør med beliggende på Niels Bohr Institutet, videreudvikler forskernes ide med kommercielt sigte. derne' hest, kun

  12. Fragile X-Linked Mental Retardation and Macro-orchidism

    PubMed Central

    Moore, Byron C.; Glover, Thomas W.; Kaiser-McCaw, Barbara; Hecht, Frederick

    1982-01-01

    A fragile site near the end of the long arm (q) of the X chromosome appears to be directly related to the gene responsible for the mental retardation found among males and some females who possess this variant X chromosome. Macro-orchidism is present in most males studied. Other mild phenotypic similarities may exist. The expression of the fragile X (fra[X]) chromosome is dependent on the concentration of folic acid and thymidine in the culture medium, which partly explains why fra(X) was not noted earlier and connected promptly with X-linked mental retardation. Whereas prenatal diagnosis is now possible, genetic counseling is complicated by recent reports of “intellectually normal” fra(X) males. Further studies are needed to form solid conclusions about intellectual deficits, learning behavior or personality characteristics of fra(X) persons. ImagesFigure 1 PMID:7179944

  13. Semi-Analytic Gain Control Algorithm for the Fiber Raman Amplifier under Dynamic Channel Reconfiguration

    E-print Network

    Park, Namkyoo

    /drop. To assess the FRA-transient related issues such as cross gain modulation, SSRS (Signal Stimulated Raman, especially in deep saturation regime where pump depletion / SSRS effects manifest. In this work, we present

  14. Lunar Sample Compendium C Meyer 2010

    E-print Network

    Rathbun, Julie A.

    that this soil is ~ 76 % anorthosite, 11 % KREEP, 9 % mare basalt and 3 % meteorite, while Kempa et al. (1980) calculate ~ 60 % anorthosite, 30 % low-K Fra Mauro (impact melt) and 10 % mare basalt (using components

  15. 75 FR 40021 - Agency Information Collection Activities; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-13

    ...rail-related suicide. Psychological autopsy is a recognized and...person's death. The 60 psychological autopsies for the FRA project...industry to design, pilot test and implement effective countermeasures...reducing deaths, injuries and psychological trauma. Form...

  16. 75 FR 57546 - Notice and Request for Comments

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-21

    ...rail-related suicide. Psychological autopsy is a recognized and...person's death. The 60 psychological autopsies for the FRA project...industry to design, pilot test and implement effective countermeasures...reducing deaths, injuries and psychological trauma. Form...

  17. 75 FR 76345 - Risk Reduction Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-08

    ... Secretary has since delegated those responsibilities to the FRA Administrator. See 49 CFR 1.49(oo); 74 FR... employees' circadian rhythm. Alertness strategies, such as policies on napping, to address acute...

  18. 75 FR 22674 - Moynihan Station Development Project

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-29

    ... Quality NEPA implementing regulations, 40 CFR parts 1500-1508, and the FRA NEPA procedures, 64 FR 28545... Federal Railroad Administration Moynihan Station Development Project AGENCY: Federal Railroad... comment period for the Moynihan Station Development Project Environmental Assessment. SUMMARY: The...

  19. 49 CFR 211.45 - Petitions for emergency waiver of safety rules.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... hearing pursuant to the provisions contained in 49 CFR part 211; or (3) Determine that a public hearing is... document submitted to the docket in 2009 will be identified as FRA-2009-XXX-1.) Thus, each...

  20. 49 CFR 211.45 - Petitions for emergency waiver of safety rules.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... hearing pursuant to the provisions contained in 49 CFR part 211; or (3) Determine that a public hearing is... document submitted to the docket in 2009 will be identified as FRA-2009-XXX-1.) Thus, each...

  1. 49 CFR 211.45 - Petitions for emergency waiver of safety rules.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... hearing pursuant to the provisions contained in 49 CFR part 211; or (3) Determine that a public hearing is... document submitted to the docket in 2009 will be identified as FRA-2009-XXX-1.) Thus, each...

  2. 49 CFR 211.45 - Petitions for emergency waiver of safety rules.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... hearing pursuant to the provisions contained in 49 CFR part 211; or (3) Determine that a public hearing is... document submitted to the docket in 2009 will be identified as FRA-2009-XXX-1.) Thus, each...

  3. 49 CFR 211.45 - Petitions for emergency waiver of safety rules.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... hearing pursuant to the provisions contained in 49 CFR part 211; or (3) Determine that a public hearing is... document submitted to the docket in 2009 will be identified as FRA-2009-XXX-1.) Thus, each...

  4. 49 CFR Appendix C to Part 218 - Statement of Agency Enforcement Policy on Tampering

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...associated with advanced train control systems currently undergoing research testing. FRA has been advised by portions of the regulated...about the proper interpretation of the word “knowingly” stems from both normal canons of statutory construction and...

  5. 49 CFR Appendix C to Part 218 - Statement of Agency Enforcement Policy on Tampering

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...associated with advanced train control systems currently undergoing research testing. FRA has been advised by portions of the regulated...about the proper interpretation of the word “knowingly” stems from both normal canons of statutory construction and...

  6. 49 CFR Appendix C to Part 218 - Statement of Agency Enforcement Policy on Tampering

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...associated with advanced train control systems currently undergoing research testing. FRA has been advised by portions of the regulated...about the proper interpretation of the word “knowingly” stems from both normal canons of statutory construction and...

  7. 49 CFR Appendix C to Part 218 - Statement of Agency Enforcement Policy on Tampering

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...associated with advanced train control systems currently undergoing research testing. FRA has been advised by portions of the regulated...about the proper interpretation of the word “knowingly” stems from both normal canons of statutory construction and...

  8. 49 CFR Appendix C to Part 218 - Statement of Agency Enforcement Policy on Tampering

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...associated with advanced train control systems currently undergoing research testing. FRA has been advised by portions of the regulated...about the proper interpretation of the word “knowingly” stems from both normal canons of statutory construction and...

  9. 75 FR 16562 - High-Speed Intercity Passenger Rail (HSIPR) Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-01

    ...ACTION: Notice of solicitation for proposals for Federally-led multi- state passenger rail corridor planning demonstration...from groups of States interested in participating in a FRA-led demonstration project that could provide a future model for...

  10. Rungende malm og rbende roser.* En anmeldelse af Jakob Wolf (2004): Rosens Rb. Intelligent design i naturen.

    E-print Network

    Emmeche, Claus

    2004-01-01

    dårlig teologi, naturvidenskabelige åbne spørgsmål og fejlagtige argumenter og slutninger ud fra vores, der er gode afsnit om Kants teleologi, og bogen kan anbefales som en første indføring i denne bizarre

  11. 76 FR 2199 - Locomotive Safety Standards

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-12

    ... analysis for new locomotive electronic systems. FRA believes this proposal will modernize and improve its..., railroad track, signal systems, communications, rolling stock, operating practices, passenger train... requirements for brake, draft, suspension, and electrical systems, and locomotive cabs; and locomotive...

  12. 77 FR 74737 - Petition for Waiver of Compliance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-17

    ... October 26, 2012, the Port Manatee Railroad (PMRR) has petitioned the Federal Railroad Administration (FRA... performed within the confines of Port Manatee, which consists of slow speed yard tracks. Additionally,...

  13. 49 CFR 236.1023 - Errors and malfunctions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., MAINTENANCE, AND REPAIR OF SIGNAL AND TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Positive Train Control... appropriate risk analysis, the railroad shall: (1) Notify the applicable vendor or supplier and FRA of...

  14. 49 CFR 236.1023 - Errors and malfunctions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ..., MAINTENANCE, AND REPAIR OF SIGNAL AND TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Positive Train Control... appropriate risk analysis, the railroad shall: (1) Notify the applicable vendor or supplier and FRA of...

  15. Frodig natur, historiske byer, pomp og prakt og tradisjon! Bli med Universitetets Seniorforening til

    E-print Network

    Gerhardy, Philipp

    til SKOTTLAND M ILITARY TATTOO #12;Dag 1: Norge - Skottland Fra Oslo flyr vi direkte til Edinburgh førsteklasses skotske råvarer som biff, laks og lam. Dag 5: Edinburgh og Tattoo (frivillig utflukt) Idag tilbyr

  16. 49 CFR Appendix D to Part 230 - Civil Penalty Schedule

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...otherwise test when FRA inspector or steam locomotive owner and/or operator...42Failure to have accurate boiler steam gauge where engine crew can conveniently read 2...gauge siphon of proper capacity on steam gauge supply pipe; failure...

  17. 49 CFR Appendix D to Part 230 - Civil Penalty Schedule

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...otherwise test when FRA inspector or steam locomotive owner and/or operator...42Failure to have accurate boiler steam gauge where engine crew can conveniently read 2...gauge siphon of proper capacity on steam gauge supply pipe; failure...

  18. 49 CFR Appendix D to Part 230 - Civil Penalty Schedule

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...otherwise test when FRA inspector or steam locomotive owner and/or operator...42Failure to have accurate boiler steam gauge where engine crew can conveniently read 2...gauge siphon of proper capacity on steam gauge supply pipe; failure...

  19. 77 FR 69918 - Notice and Request for Comments

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-21

    ...the potential to curtail future mobility and economic growth in the region. Thus, FRA established the Northeast Corridor (NEC) Future Program to develop a Passenger Rail Corridor Investment Plan (PRCIP) for the Northeast region. The PRCIP will...

  20. 78 FR 47822 - Notice of Application for Approval of Discontinuance or Modification of a Railroad Signal System

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-06

    ...petition Docket Number FRA-2013-0076. Applicant: Port of Los Angeles, Mr. Ron Groves, PE, Senior Civil Engineer, Engineering Division, 425 South Palos Verdes Street, San Pedro, CA 90731. POLA seeks approval of the proposed...

  1. Det matematisk-naturvitenskapelige fakultet Universitetet i Oslo

    E-print Network

    Gerhardy, Philipp

    O?: Tilleggsopplysninger (evt tidligere saksnummer): Dokumentasjon som må vedlegges søknaden: Emnebeskrivelser et offentlig kontor, f.eks. universitetet, høgskole, politi, evt. av MN-studieinfo på Blindern. Fra

  2. 49 CFR 238.229 - Safety appliances-general.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...the safety appliance. FRA does allow the welded attachment of a brace or stiffener used in connection with a mechanically fastened safety appliance. In order to be considered a “brace” or “stiffener,” the component or part shall not be...

  3. 49 CFR 238.229 - Safety appliances-general.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...the safety appliance. FRA does allow the welded attachment of a brace or stiffener used in connection with a mechanically fastened safety appliance. In order to be considered a “brace” or “stiffener,” the component or part shall not be...

  4. Acute Toxicological Responses of Fischer Rats to Naturally Occurring Asbestos from theUnited States and Canada

    EPA Science Inventory

    This study was designed to provide understanding of the toxicity of naturally occurring asbestos (NOA) including Libby amphibole (LA), Sumas Mountain chrysotile (SM), EI Dorado Hills tremolite (ED) and Ontario actinolite/ferroactinolite cleavage fragments (ON). Ratrespirable fra...

  5. 76 FR 23714 - Railroad Safety Appliance Standards

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-28

    ...construction, under which much of the modern rail equipment presently is built. While...standards incorporating changes based on modern railcar design, FRA expects that the...serve the goal of adapting to changes in modern railcar design while also...

  6. 75 FR 59108 - Positive Train Control Systems

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-27

    ...discussed at a meeting of the RSAC PTC Working Group conducted by webinar on March...rule were being prepared, FRA was working to place development of this methodology under contract, and the PTC Working Group was forming a task...

  7. 77 FR 40144 - Adoption of the Environmental Impact Statement (EIS) and Participation in the Section 106...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-06

    ...AGENCY: Federal Railroad Administration (FRA), Department of Transportation (DOT). ACTION: Notice of adoption and recirculation of the Final Environmental Impact Statement for the East Side Access Project and participation in the Section 106...

  8. 77 FR 21620 - Notice of the Buy America Waiver Request for Vossloh 101-LV Concrete Ties

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-10

    ...America Waiver Request for Vossloh 101-LV Concrete Ties AGENCY: Federal Railroad Administration...for the purchase of Vossloh 101-LV concrete ties, which contain certain components...the installation of Vossloh 101-LV concrete ties. FRA has received this...

  9. 78 FR 48765 - Petition for Waiver of Compliance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-09

    ...consists of representatives from Class I railroads, labor unions, car builders, private car owners, and shippers, along with ergonomics experts and government representatives from FRA and Transport Canada who participate as non-voting members. The Task...

  10. 75 FR 12811 - Petition for Waiver of Compliance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-17

    ...DEPARTMENT OF TRANSPORTATION Federal Railroad Administration Petition for Waiver of...notice is hereby given that the Federal Railroad Administration (FRA) has received a...including verifying the integrity of underground cable connecting the solid-state...

  11. 78 FR 20169 - Notice of Availability of an Environmental Assessment for the Proposed Hudson Yards Concrete...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-03

    ...public that the National Railroad Passenger Corporation...coordination with Federal Railroad Administration (FRA...the construction of an underground concrete casing to preserve...impacts of constructing an underground concrete casing in the...Fishburne, USDOT, Federal Railroad Administration,...

  12. 75 FR 36551 - State Highway-Rail Grade Crossing Action Plans

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-28

    ...the ten identified States and the burden resubmission from the quantum that may not comply during the initial submission. FRA considers...Development of such plans will enhance these States' ability to view their population of grade crossings, interpret historical...

  13. 78 FR 3289 - Department Regulatory Agenda; Semiannual Summary

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-15

    ...the beginning of PATT in 1985. Currently, FRA tests blood and urine specimens for eight drug classifications: alcohol, marijuana, cocaine, the opiates, the amphetamines, phencyclidine (PCP), the barbiturates, and the benzodiazepines....

  14. 49 CFR 225.37 - Optical media transfer and electronic submission.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...: (1) An electronic image of the completed and signed hard copy of the Railroad Injury and Illness... FRA at aireports@frasafety.net: (i) An electronic image of the completed and signed hard copy of...

  15. 49 CFR 225.37 - Optical media transfer and electronic submission.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...: (1) An electronic image of the completed and signed hard copy of the Railroad Injury and Illness... FRA at aireports@frasafety.net: (i) An electronic image of the completed and signed hard copy of...

  16. 78 FR 18668 - Proposed Agency Information Collection Activities; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-27

    ...493-6497, or via email to Mr. Brogan at Robert.Brogan...FURTHER INFORMATION CONTACT: Mr. Robert Brogan, Office of Planning...Locomotive Certification (Noise Compliance Regulations). OMB...Regulations (CFR) pertains to FRA's noise enforcement procedures...

  17. 78 FR 36817 - Proposed Agency Information Collection Activities; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-19

    ...FURTHER INFORMATION CONTACT: Mr. Robert Brogan, Office of...Locomotive Certification (Noise Compliance Regulations...CFR) pertains to FRA's noise enforcement procedures which encompass rail yard noise source standards...

  18. 75 FR 32237 - Information Collection Requirements

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-07

    ...hours. Title: Locomotive Certification (Noise Compliance Regulations). OMB Control Number...Federal Regulations (CFR) pertains to FRA's noise enforcement procedures which encompass rail yard noise source standards published by the...

  19. 75 FR 16896 - Proposed Agency Information Collection Activities; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-02

    ...hours. Title: Locomotive Certification (Noise Compliance Regulations). OMB Control Number...Federal Regulations (CFR) pertains to FRA's noise enforcement procedures which encompass rail yard noise source standards published by the...

  20. Fuzzy Risk Analyzer

    Energy Science and Technology Software Center (ESTSC)

    1994-03-04

    FRA is a general purpose code for risk analysis using fuzzy, not numeric, attributes. It allows the user to evaluate the risk associated with a composite system on the basis of the risk estimates of the individual components.

  1. 78 FR 31628 - Environmental Impact Statement for the Milwaukee, WI to Minneapolis, MN Rail Corridor

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-24

    ... Procedures for Considering Environmental Impacts (64 FR 28545; May 26, 1999). FRA and MnDOT will use a tiered... for the proposed action is based on the limitations and vulnerabilities of available travel...

  2. 75 FR 16562 - High-Speed Intercity Passenger Rail (HSIPR) Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-01

    ... proposals for Federally-led multi- state passenger rail corridor planning demonstration projects. SUMMARY... proposals from groups of States interested in participating in a FRA-led demonstration project that...

  3. 78 FR 77787 - Notice of Application for Approval of Discontinuance or Modification of a Railroad Signal System

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-24

    ...discontinuance or modification of a signal system. FRA assigned the petition Docket...discontinuance of the signal system between Milepost (MP) 359...installation of a new signal system in support of the Hardy Toll Road project. UP estimates...

  4. 75 FR 20035 - Petition for Waiver of Compliance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-16

    ...being requested, and the petitioner's arguments in favor of relief. City of Jasper, Indiana [Docket Number FRA-2009-0112] The City of Jasper, Indiana (Jasper) acquired a railroad passenger car, number XCJI 200, built in 1947,...

  5. 75 FR 3959 - Railroad Safety Advisory Committee; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-25

    ... FR 9740), for additional information about the RSAC. Issued in Washington, DC on January 19, 2010... Management, and Conductor Certification. FRA may offer a new task on Minimum Training Standards for...

  6. 49 CFR 242.5 - Effect and construction.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ..., DEPARTMENT OF TRANSPORTATION QUALIFICATION AND CERTIFICATION OF CONDUCTORS General § 242.5 Effect and construction. (a) FRA does not intend, by use of the term conductor in this part, to alter the...

  7. 75 FR 32240 - Draft Tier II Environmental Impact Statement: Southeast High Speed Rail Corridor-Richmond, VA...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-07

    ... Quality NEPA implementing regulations, 40 CFR parts 1500-1508, and the FRA NEPA guidance, 64 FR 28545 (May... (telephone 804-786-1052) or by e-mail at christine.fix@drpt.virginia.gov , with ``SEHSR Richmond to...

  8. 75 FR 38343 - High-Speed Intercity Passenger Rail (HSIPR) Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-01

    ...and the decision to use tiering or a unified project-level document. FRA encourages...demand model structure including example equations and elasticities. ii. Describe the...tier, NEPA will be satisfied through a unified project-level document...

  9. 78 FR 5767 - Positive Train Control Systems (RRR)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-28

    ...questions concerning those elements. This document does not alter FRA's proposal as issued December 11, 2012, but it does...balance the statutory mandate for increased safety with the realities of implementing new and previously undeveloped systems,...

  10. 78 FR 65422 - Agency Request for Emergency Processing of Collections of Information Associated With Today's...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-31

    ..., may be obtained by calling FRA's Clearance Officer, Mr. Robert Brogan (tel. (202) 493-6292). These numbers are not toll-free. A copy of this ICR may also be obtained electronically by contacting Mr....

  11. 49 CFR Appendix A to Part 238 - Schedule of Civil Penalties 1

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...equipment at the time of movement. Failure to observe any condition for the movement of passenger equipment...deprive the railroad of the movement-for-repair...facilitate assessment of civil penalties, and...any. FRA reserves the right, should...

  12. 49 CFR Appendix A to Part 238 - Schedule of Civil Penalties 1

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...equipment at the time of movement. Failure to observe any condition for the movement of passenger equipment...deprive the railroad of the movement-for-repair...facilitate assessment of civil penalties, and...any. FRA reserves the right, should...

  13. 49 CFR Appendix A to Part 238 - Schedule of Civil Penalties 1

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...equipment at the time of movement. Failure to observe any condition for the movement of passenger equipment...deprive the railroad of the movement-for-repair...facilitate assessment of civil penalties, and...any. FRA reserves the right, should...

  14. 49 CFR Appendix A to Part 238 - Schedule of Civil Penalties 1

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...equipment at the time of movement. Failure to observe any condition for the movement of passenger equipment...deprive the railroad of the movement-for-repair...facilitate assessment of civil penalties, and...any. FRA reserves the right, should...

  15. ZUR SACHE FORSCHUNGSPOLITIK 3 / 2 0 0 7 M A X P L A N C K F O R S C H U N G 15

    E-print Network

    Falge, Eva

    kleinen Abteilung unter Otto Hahn, während Fra- gen der organischen und anorganischen Chemie in den großen Hauptschwerpunkt und die zuständigen Abteilungs- leiter Hahn und Lise Meitner gehörten weltweit zu den führenden

  16. 78 FR 4978 - Proposed Agency Information Collection Activities; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-23

    .... 104-13, Sec. 2, 109 Stat. 163 (1995) (codified as revised at 44 U.S.C. 3501-3520), and its.... 44 U.S.C. 3506(c)(2)(A); 5 CFR 1320.8(d)(1), 1320.10(e)(1), 1320.12(a). Specifically, FRA invites... responses). See 44 U.S.C. 3506(c)(2)(A)(i)-(iv); 5 CFR 1320.8(d)(1)(i)-(iv). FRA believes that...

  17. 787revision:2002-01-12modified:2002-01-12 Almost free groups and Ehrenfeucht-Fraisse games

    E-print Network

    Shelah, Saharon

    787revision:2002-01-12modified:2002-01-12 Almost free groups and Ehrenfeucht-Fra¨iss´e games-structure theorems for almost free Abelian groups by studying long Ehrenfeucht-Fra¨iss´e games between a fixed group of cardinality and a free Abelian group. A group is called -game-free if the isomorphism player has a winning

  18. revision:20020112 modified:20020112

    E-print Network

    Shelah, Saharon

    787 revision:2002­01­12 modified:2002­01­12 Almost free groups and Ehrenfeucht­FraË?�ssâ??e games non­structure theorems for almost free Abelian groups by studying long Ehrenfeucht­FraË?�ssâ??e games between a fixed group of cardinality # and a free Abelian group. A group is called #­game­free

  19. SOLUZIONI Primo appello Febbraio 2006. (N.B.: Possono essere presenti errori di battitura!)

    E-print Network

    Lipparini, Paolo

    equazione y + µz = 0, con e µ numeri reali non entrambi nulli. Se = 0 si ottiene il piano di equazione z variare di k fra i numeri reali, rappresenta tutti i piani F, ad eccezione del piano z = 0. c) `E parametro, e cio`e (x, 0, 0), al variare di x fra i numeri reali. Se µ = 1/3 e = 0 , la matrice ha rango 1

  20. Differential expression of fragile site Xq27 in cultured fibroblasts from hemizygotes and heterozygotes and its implications for prenatal diagnosis.

    PubMed

    Schmidt, A; Passarge, E

    1986-01-01

    Expression of the fragile site Xq27 (fraXq27) was studied in metaphases derived from fibroblasts of 8 hemizygotes and 2 heterozygotes, cultured in 2 different media containing reduced concentrations of folic acid. The proportion of fra(X) (q27)-positive metaphases ranged from 1.0 to 14%, which is considerably lower than in lymphocyte cultures from the same individual, but differed with respect to the culture medium used. Four hemizygotes showed a higher proportion of fra(X)-positive cells in medium 199 than in methotrexate-exposed cultures. No fra(X)-negative cultures were observed when the folic acid inhibitor methotrexate was added to medium 199. Thus, in all 10 individuals carrying the fra(X), the fragile site could be detected in fibroblast cultures. We conclude that the expression of fra(X) (q27) in cultured fibroblasts should be studied using at least 2 types of culture conditions, because familial, i.e. genetic differences may influence the expression of this fragile site in fibroblasts. The implications for prenatal diagnosis are discussed on the basis of investigations in 15 pregnancies at risk for the trait. PMID:3953662

  1. Molecular Insights into Frataxin-Mediated Iron Supply for Heme Biosynthesis in Bacillus subtilis

    PubMed Central

    Mielcarek, Andreas; Blauenburg, Bastian; Miethke, Marcus; Marahiel, Mohamed A.

    2015-01-01

    Iron is required as an element to sustain life in all eukaryotes and most bacteria. Although several bacterial iron acquisition strategies have been well explored, little is known about the intracellular trafficking pathways of iron and its entry into the systems for co-factor biogenesis. In this study, we investigated the iron-dependent process of heme maturation in Bacillus subtilis and present, for the first time, structural evidence for the physical interaction of a frataxin homologue (Fra), which is suggested to act as a regulatory component as well as an iron chaperone in different cellular pathways, and a ferrochelatase (HemH), which catalyses the final step of heme b biogenesis. Specific interaction between Fra and HemH was observed upon co-purification from crude cell lysates and, further, by using the recombinant proteins for analytical size-exclusion chromatography. Hydrogen–deuterium exchange experiments identified the landscape of the Fra/HemH interaction interface and revealed Fra as a specific ferrous iron donor for the ferrochelatase HemH. The functional utilisation of the in vitro-generated heme b co-factor upon Fra-mediated iron transfer was confirmed by using the B. subtilis nitric oxide synthase bsNos as a metabolic target enzyme. Complementary mutational analyses confirmed that Fra acts as an essential component for maturation and subsequent targeting of the heme b co-factor, hence representing a key player in the iron-dependent physiology of B. subtilis. PMID:25826316

  2. Effect of serotonin on the expression of antigens and DNA levels in Yersinia pestis cells with different plasmid content

    NASA Astrophysics Data System (ADS)

    Klueva, Svetlana N.; Korsukov, Vladimir N.; Schukovskaya, Tatyana N.; Kravtsov, Alexander L.

    2004-08-01

    Using flow cytometry (FCM) the influence of exogenous serotonin on culture growth, DNA content and fluorescence intensity of cells binding FITC-labelled plague polyclonal immunoglobulins was studied in Yersinia pestis EV (pFra+, pCad+, pPst+), Yersinia pestis KM218 (pFra-, pCad-, pPst-), Yersinia pestis KM 216 (pFra-, pCad-, pPst+). The results have been obtained by FCM showed serotonin accelerated Yersinia pestis EV (pFra+, pCad+, pPst+), Yersinia pestis KM218 (pFra-, pCad-, pPst-) culture growth during cultivation in Hottinger broth pH 7.2 at 28°C at concentration of 10-5 M. The presence of 10-5 M serotonin in nutrient broth could modulate DNA content in 37°C growing population of plague microbe independently of their plasmid content. Serotonin have been an impact on the distribution pattern of the cells according to their phenotypical characteristics, which was reflected in the levels of population heterogeneity in the intensity of specific immunofluorescence determined by FMC.

  3. Structural and functional diversity of metalloproteinases encoded by the Bacteroides fragilis pathogenicity island

    PubMed Central

    Shiryaev, Sergey A.; Aleshin, Alexander E.; Muranaka, Norihito; Kukreja, Muskan; Routenberg, David A.; Remacle, Albert G.; Liddington, Robert C.; Cieplak, Piotr; Kozlov, Igor A.; Strongin, Alex Y.

    2014-01-01

    Summary Bacteroides fragilis causes the majority of anaerobic infections in humans. The presence of a pathogenicity island in the genome discriminates pathogenic and commensal B. fragilis strains. The island encodes metalloproteinase II (MPII), a potential virulence protein, and one of three homologous fragilysin isozymes (FRA; also termed B. fragilis toxin or BFT). Here, we report biochemical data on the structural-functional characteristics of the B. fragilis pathogenicity island proteases by reporting the crystal structure of MPII at 2.13 Å resolution combined with detailed characterization of the cleavage preferences of MPII and FRA3 (as a representative of the FRA isoforms) identified using a high-throughput peptide cleavage assay with 18,583 substrate peptides. We suggest that the evolution of the MPII catalytic domain can be traced to human and archaebacterial proteinases, while the prodomain fold is a feature specific to MPII and FRA. We conclude that the catalytic domain of both MPII and FRA3 evolved differently relative to the prodomain, and that the prodomain evolved specifically to fit the B. fragilis pathogenicity. Overall, our data provide insights into the evolution of cleavage specificity and activation mechanisms in the virulent metalloproteinases. PMID:24698179

  4. Flamingo, a seven-pass transmembrane cadherin, cooperates with Netrin/Frazzled in Drosophila midline guidance.

    PubMed

    Organisti, Cristina; Hein, Irina; Grunwald Kadow, Ilona C; Suzuki, Takashi

    2015-01-01

    During central nervous system development, several guidance cues and receptors, as well as cell adhesion molecules, are required for guiding axons across the midline and along the anterior-posterior axis. In Drosophila, commissural axons sense the midline attractants Netrin A and B (Net) through Frazzled (Fra) receptors. Despite their importance, lack of Net or fra affects only some commissures, suggesting that additional molecules can fulfill this function. Recently, planar cell polarity (PCP) proteins have been implicated in midline axon guidance in both vertebrate and invertebrate systems. Here, we report that the atypical cadherin and PCP molecule Flamingo/Starry night (Fmi/Stan) acts jointly with Net/Fra signaling during midline development. Additional removal of fmi strongly increases the guidance defects in Net/fra mutants. Rescue and domain deletion experiments suggest that Fmi signaling facilitates commissural pathfinding potentially by mediating axonal fasciculation in a partly homophilic manner. Altogether, our results indicate that contact-mediated cell adhesion via Fmi acts in addition to the Net/Fra guidance system during axon pathfinding across the midline, underlining the importance of PCP molecules during vertebrates and invertebrates midline development. PMID:25440577

  5. Bidirectional Transformation of a Metamorphic Protein between the Water-Soluble and Transmembrane Native States.

    PubMed

    Tanaka, Koji; Caaveiro, Jose M M; Tsumoto, Kouhei

    2015-11-24

    The bidirectional transformation of a protein between its native water-soluble and integral transmembrane conformations is demonstrated for FraC, a hemolytic protein of the family of pore-forming toxins. In the presence of biological membranes, the water-soluble conformation of FraC undergoes a remarkable structural reorganization generating cytolytic transmembrane nanopores conducive to cell death. So far, the reverse transformation from the native transmembrane conformation to the native water-soluble conformation has not been reported. We describe the use of detergents with different physicochemical properties to achieve the spontaneous conversion of transmembrane pores of FraC back into the initial water-soluble state. Thermodynamic and kinetic stability data suggest that specific detergents cause an asymmetric change in the energy landscape of the protein, allowing the bidirectional transformation of a membrane protein. PMID:26544760

  6. Fructose-Asparagine Is a Primary Nutrient during Growth of Salmonella in the Inflamed Intestine

    PubMed Central

    Ali, Mohamed M.; Newsom, David L.; González, Juan F.; Sabag-Daigle, Anice; Stahl, Christopher; Steidley, Brandi; Dubena, Judith; Dyszel, Jessica L.; Smith, Jenee N.; Dieye, Yakhya; Arsenescu, Razvan; Boyaka, Prosper N.; Krakowka, Steven; Romeo, Tony; Behrman, Edward J.; White, Peter; Ahmer, Brian M. M.

    2014-01-01

    Salmonella enterica serovar Typhimurium (Salmonella) is one of the most significant food-borne pathogens affecting both humans and agriculture. We have determined that Salmonella encodes an uptake and utilization pathway specific for a novel nutrient, fructose-asparagine (F-Asn), which is essential for Salmonella fitness in the inflamed intestine (modeled using germ-free, streptomycin-treated, ex-germ-free with human microbiota, and IL10?/? mice). The locus encoding F-Asn utilization, fra, provides an advantage only if Salmonella can initiate inflammation and use tetrathionate as a terminal electron acceptor for anaerobic respiration (the fra phenotype is lost in Salmonella SPI1? SPI2? or ttrA mutants, respectively). The severe fitness defect of a Salmonella fra mutant suggests that F-Asn is the primary nutrient utilized by Salmonella in the inflamed intestine and that this system provides a valuable target for novel therapies. PMID:24967579

  7. Realistic Transverse Images of the Proton Charge and Magnetic Densities

    E-print Network

    Siddharth Venkat; John Arrington; Gerald A. Miller; Xiaohui Zhan

    2010-11-05

    We develop a technique, denoted as the finite radius approximation (FRA), that uses a two-dimensional version of the Shannon-Nyquist sampling theorem to determine transverse densities and their uncertainties from experimental quantities. Uncertainties arising from experimental uncertainties on the form factors and lack of measured data at high $Q^2$ are treated. A key feature of the FRA is that a form factor measured at a given value of $Q^2$ is related to a definite region in coordinate space. An exact relation between the FRA and the use of a Bessel series is derived. The proton Dirac form factor is well enough known such that the transverse charge density is very accurately known except for transverse separations $b$ less than about 0.1 fm. The Pauli form factor is well known to $Q^2$ of about 10 GeV$^2$, and this allows a reasonable, but improvable, determination of the anomalous magnetic moment density.

  8. New polymorphic DNA marker close to the fragile site FRAXA.

    PubMed

    Oostra, B A; Hupkes, P E; Perdon, L F; van Bennekom, C A; Bakker, E; Halley, D J; Schmidt, M; Du Sart, D; Smits, A; Wieringa, B

    1990-01-01

    DNA from a human-hamster hybrid cell line, 908-K1B17, containing a small terminal portion of the long arm of the human X chromosome as well as the pericentric region of 19q was used as starting material for the isolation of an X-chromosome-specific DNA segment, RN1 (DXS369), which identifies a XmnI RFLP. Linkage analysis in fragile X families resulted in a maximum lod score of 15.3 at a recombination fraction of 0.05 between RN1 and fra(X). Analysis of recombinations around the fra(X) and distal to DXS105. Analysis of the marker content of hybrid cell line 908K1B17 suggests the localization of RN1 between DXS98 and fra(X). Heterozygosity of DXS369 is approximately 50%, which extends the diagnostic potential of RFLP analysis in fragile X families significantly. PMID:1968042

  9. Regulation of Heart Rate in Drosophila via Fragile X Mental Retardation Protein

    PubMed Central

    Novak, Stefanie Mares; Joardar, Archi; Gregorio, Carol C.; Zarnescu, Daniela C.

    2015-01-01

    RNA binding proteins play a pivotal role in post-transcriptional gene expression regulation, however little is understood about their role in cardiac function. The Fragile X (FraX) family of RNA binding proteins is most commonly studied in the context of neurological disorders, as mutations in Fragile X Mental Retardation 1 (FMR1) are the leading cause of inherited mental retardation. More recently, alterations in the levels of Fragile X Related 1 protein, FXR1, the predominant FraX member expressed in vertebrate striated muscle, have been linked to structural and functional defects in mice and zebrafish models. FraX proteins are established regulators of translation and are known to regulate specific targets in different tissues. To decipher the direct role of FraX proteins in the heart in vivo, we turned to Drosophila, which harbors a sole, functionally conserved and ubiquitously expressed FraX protein, dFmr1. Using classical loss of function alleles as well as muscle specific RNAi knockdown, we show that Drosophila FMRP, dFmr1, is required for proper heart rate during development. Functional analyses in the context of cardiac-specific dFmr1 knockdown by RNAi demonstrate that dFmr1 is required cell autonomously in cardiac cells for regulating heart rate. Interestingly, these functional defects are not accompanied by any obvious structural abnormalities, suggesting that dFmr1 may regulate a different repertoire of targets in Drosophila than in vertebrates. Taken together, our findings support the hypothesis that dFmr1 protein is essential for proper cardiac function and establish the fly as a new model for studying the role(s) of FraX proteins in the heart. PMID:26571124

  10. Intercellular Diffusion of a Fluorescent Sucrose Analog via the Septal Junctions in a Filamentous Cyanobacterium

    PubMed Central

    Nürnberg, Dennis J.; Mariscal, Vicente; Bornikoel, Jan; Nieves-Morión, Mercedes; Krauß, Norbert; Herrero, Antonia

    2015-01-01

    ABSTRACT Many filamentous cyanobacteria produce specialized nitrogen-fixing cells called heterocysts, which are located at semiregular intervals along the filament with about 10 to 20 photosynthetic vegetative cells in between. Nitrogen fixation in these complex multicellular bacteria depends on metabolite exchange between the two cell types, with the heterocysts supplying combined-nitrogen compounds but dependent on the vegetative cells for photosynthetically produced carbon compounds. Here, we used a fluorescent tracer to probe intercellular metabolite exchange in the filamentous heterocyst-forming cyanobacterium Anabaena sp. strain PCC 7120. We show that esculin, a fluorescent sucrose analog, is incorporated by a sucrose import system into the cytoplasm of Anabaena cells. The cytoplasmic esculin is rapidly and reversibly exchanged across vegetative-vegetative and vegetative-heterocyst cell junctions. Our measurements reveal the kinetics of esculin exchange and also show that intercellular metabolic communication is lost in a significant fraction of older heterocysts. SepJ, FraC, and FraD are proteins located at the intercellular septa and are suggested to form structures analogous to gap junctions. We show that a ?sepJ ?fraC ?fraD triple mutant shows an altered septum structure with thinner septa but a denser peptidoglycan layer. Intercellular diffusion of esculin and fluorescein derivatives is impaired in this mutant, which also shows a greatly reduced frequency of nanopores in the intercellular septal cross walls. These findings suggest that FraC, FraD, and SepJ are important for the formation of junctional structures that constitute the major pathway for feeding heterocysts with sucrose. PMID:25784700

  11. Significance of Folate Receptor alpha and Thymidylate Synthase Protein Expression in Patients with Non-Small Cell Lung Cancer treated with Pemetrexed

    PubMed Central

    Christoph, Daniel C; Asuncion, Bernadette Reyna; Hassan, Biftu; Tran, Cindy; Maltzman, Julia D; O’Shannessy, Daniel J; Wynes, Murry W; Gauler, Thomas C; Wohlschlaeger, Jeremias; Hoiczyk, Mathias; Schuler, Martin; Eberhardt, Wilfried E; Hirsch, Fred R

    2013-01-01

    Introduction Folate receptor alpha (FRA) regulates cellular uptake of folates and antifolates. Information about FRA protein expression in metastatic Non-Small Cell Lung Cancer (NSCLC) is limited. We investigated FRA as a biomarker for pemetrexed-based chemotherapy and compared it to thymidylate synthase (TS), the main target of pemetrexed. Materials and Methods Pre-treatment tumor specimens from 207 NSCLC patients with advanced disease were assessed for FRA and TS protein expression by immunohistochemistry using the H-score (range: 0–300) and correlated to patients’ clinicopathological data, radiographic response (RECIST), progression-free survival (PFS) and overall survival (OS). Results Low total (cytoplasmic and nuclear) TS protein expression (H-score <210) was associated with improved PFS (median: 5.6 vs. 3.5 months; HR=0.6379, P=0.0131) and prolonged OS (median: 22.5 vs. 11.5 months; HR: 0.5680, P=0.0107). An association between lower TS levels and response to pemetrexed-based therapy was found: mean H-score 187±5, median 180 for responders vs. 201±4, median 210, P=0.0244. High intracellular FRA expression (H-score ? 110) was associated with prolonged OS (28.9 vs. 11.7 months, HR=0.5316, P=0.0040) and a trend for association with PFS (5.6 vs. 4.1 months, HR=0.7395, P=0.0801) was noted. Membranous FRA expression was seen in 83% of patients, moreover, high membranous expression (H-score ?20) was associated with improved PFS (5.6 vs. 3.7 months, HR=0.6445, P=0.0306) and OS (22.1 vs. 11.5 months, HR=0.5378, P=0.0131). Conclusions A large number of NSCLC patients have high expression of FRA and/or low level of TS expression. Expression levels of FRA and TS were associated with clinical benefit from pemetrexed-therapy. PMID:23242435

  12. Current Trends and Future Challenges in the Freight Railroad Industry: Balancing Private Industry Interests and the Public Welfare 

    E-print Network

    Allen, Sarah; Kelson, Kendra; Migl, Hayden; Schmidt, Rodney; Shoemaker, David; Thomson, Heather

    2008-01-01

    ?FRA?should?allow?for?a?higher?percentage?of?funds?to?be?used?for?sight?distance? improvements,?crossing?closures?or?consolidations,?and/or?complete?grade?separations.? INDUSTRY?WIDE?RECOMMENDATIONS?OVERVIEW? ? Increase?funding?to?the?FRA?for?oversight?and?inspection?resources?with?the?purpose?of?increasing? the...?several?others?combine?to?form?a?pressing?issue?that?demands?a?collaborative? response?from?the?rail?industry,?freight?shippers,?federal?and?state?policymakers,?and?the?public.?Whether? the?future?of?the?rail?industry?is?more?or?less?regulated?is?a?policy?decision?that?will?yield?far?reaching? consequences...

  13. Major element chemistry of glasses in Apollo 14 soil 14156.

    NASA Technical Reports Server (NTRS)

    Reid, A. M.; Ridley, W. I.; Harmon, R. S.; Jakes, P.

    1973-01-01

    Glasses in a soil sample (14156) from the middle layer of the trench at the Fra Mauro landing site show a wide range of compositions clustered around certain preferred compositions. Ninety per cent of the glasses are of two major types - Fra Mauro basalt (63%) with high K and 17 wt % Al2O3 and Highland basalt or anorthositic gabbro (27%) with low K and 25 to 26 wt % Al2O3. The glass population is almost identical with that of the comprehensive soil 14259.

  14. 78 FR 28012 - Tier One Environmental Impact Statement for the Rochester, Minnesota to Twin Cities, Minnesota...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-13

    ... FRA's Procedures for Considering Environmental Impacts (64 FR 28546) (Environmental Procedures), in... consideration. Alternatives under preliminary consideration will include an alignment of the Trunk Highway 52... the proposed action and soliciting comments will be sent to the appropriate Federal, State and...

  15. SEISMIC SURFACE WAVE TESTING FOR TRACK SUBSTRUCTURE ASSESSMENT

    E-print Network

    SEISMIC SURFACE WAVE TESTING FOR TRACK SUBSTRUCTURE ASSESSMENT Timothy D. Stark and Thomas J Railroad Administration (FRA) sponsored research project on using seismic surface waves to evaluate track testing, results of field measurements, and numerical modeling of the seismic wave propagation

  16. Aalborg Universitet Prciseringer af grundlaget for SBi's vurdering af hjhusene i Rdovre

    E-print Network

    Berning, Torsten

    på en tolkning af resultater fra seks borekerneprøver, som angiveligt skulle vise, at "styrkerne bøjningstrykspænding bestemt til 49 kg/cm2 , hvor det i projek- tets beregninger er forudsat, at den skulle være 85 kg beton skulle støbes tre terningeformede prøveemner. Middelværdien af disses styrker skulle mindst svare

  17. 49 CFR 211.45 - Petitions for emergency waiver of safety rules.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...that is added to a docket. (For example, the first document submitted to the docket in 2009 will be identified as FRA-2009-XXX-1.) Thus, each petition submitted to the ERD will have a unique document number which should be identified on all...

  18. 49 CFR 211.45 - Petitions for emergency waiver of safety rules.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...that is added to a docket. (For example, the first document submitted to the docket in 2009 will be identified as FRA-2009-XXX-1.) Thus, each petition submitted to the ERD will have a unique document number which should be identified on all...

  19. 49 CFR 229.209 - Alternative locomotive crashworthiness designs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Alternative locomotive crashworthiness designs... Locomotive Crashworthiness Design Requirements § 229.209 Alternative locomotive crashworthiness designs. (a... locomotive crashworthiness designs which are not consistent with any FRA-approved locomotive...

  20. 78 FR 36817 - Proposed Agency Information Collection Activities; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-19

    ... collections of information was published on March 27, 2013 (78 FR 18668). DATES: Comments must be submitted on... seeking OMB approval. See 78 FR 18668. FRA received no comments after issuing this notice. Accordingly... 60 FR 44978, 44983, Aug. 29, 1995. OMB believes that the 30 day notice informs the...

  1. 49 CFR 225.17 - Doubtful cases; alcohol or drug involvement.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...examination by the FRA, and further inquiry may be ordered. Accidents/incidents...the railroad shall make such specific inquiry as may be reasonable under the...then the railroad shall include in the narrative statement of such report a brief...

  2. 75 FR 38592 - Solicitation of Applications and Notice of Funding Availability for Reducing the Effects of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-02

    ... Disorder (PTSD) and the more immediate Acute Distress Disorder (ASD). FRA seeks to fund a grant assessing... implementing a PTSD intervention program, along with the skills, knowledge, and resources necessary to carry... relating to PTSD, ASD, or other trauma interventions); and qualifications of primary and...

  3. The lunar highland melt-rock suite

    NASA Technical Reports Server (NTRS)

    Vaniman, D. T.; Papike, J. J.

    1978-01-01

    Size can be used as a criterion to select 18 large (larger than 1 cm) samples from among 148 melt-rock fragments of all sizes. This selection provides a suite of large samples which represent the important chemical variants among highland melt rocks; each large sample has enough material for a number of sample-destructive studies, as well as for future reference. Cluster analysis of the total data base of 148 highland melt rocks shows six distinct groups: anorthosite, gabbroic anorthosite, anorthositic gabbro ('highland basalt'), low K Fra Mauro, intermediate-K Fra Mauro, and high-K. Large samples are available for four of the melt-rock groups (gabbroic anorthosite, anorthositic gabbro, low-K Fra Mauro, and intermediate-K Fra Mauro). This sample selection reveals two subgroups of anorthositic gabbro (one anorthite-poor with negative Eu anomaly and one anorthite-rich without Eu anomaly). There is a sharp distinction between those Apollo 16 melt rocks and glasses which have both been classified as 'gabbroic anorthosite'.

  4. 75 FR 1547 - Alcohol and Drug Testing: Determination of Minimum Random Testing Rates for 2010

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-12

    ..., 1994 (59 FR 62218), FRA announced that it will set future minimum random drug and alcohol testing rates... rate has remained below 1.0 percent for the last two years of data, the Federal Railroad Administrator... the industry-wide random alcohol testing violation rate has remained below 0.5 percent for the...

  5. 77 FR 8325 - Petition for Waiver of Compliance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-14

    ... certain rail testing requirements contained in 49 CFR part 213. FRA assigned the petition Docket Number... of stop/start rail testing for phase III of its nonstop continuous rail test pilot project beginning... start/stop rail testing on track segments being nonstop continuous rail tested under this...

  6. 75 FR 2597 - Positive Train Control Systems

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-15

    ... control systems without impairing technological development. 70 FR 11,052 (Mar. 7, 2005). FRA intended... ACSES. See 63 FR 39,343 (July 22, 1998). ACSES was installed between 2000 and 2002, and has functioned....49(oo); 74 FR 26,981 (June 5, 2009); see also 49 U.S.C. 103(g). In the RSIA08, Congress...

  7. Statistical Modeling of Freight Train Derailments at Highway-Rail Level Crossings Samantha G. Chadwick, C. Tyler Dick, Mohd Rapik Saat, Christopher P.L. Barkan

    E-print Network

    Barkan, Christopher P.L.

    including train speed, highway vehicle speed, highway vehicle type, and incident type. The results less attention has been given to understanding the effect of level crossings on train safety and risk Administration (FRA) Highway Rail Grade Crossing Accident/Incident Database (4) was analyzed using SAS software

  8. 49 CFR 211.45 - Petitions for emergency waiver of safety rules.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...that is added to a docket. (For example, the first document submitted to the docket in 2009 will be identified as FRA-2009-XXX-1.) Thus, each petition submitted to the ERD will have a unique document number which should be identified on all...

  9. Automatic Structures: Richness and Limitations Bakhadyr Khoussainov # , Andre Nies + , Sasha Rubin # and Frank Stephan

    E-print Network

    Stephan, Frank

    structures. An automatic presentation of a structure is a description of the universe of the structure Boolean algebras, and it is proven that the free Abelian group of infinite rank, as well as certain FraË?�ssâ??e limits, do not have auto­ matic presentations. In particular, the countably infinite random graph

  10. 78 FR 70888 - Need for Agency Approval of a Railroad's Use of Certain Technology That Has Been Previously...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-27

    ... Technology That Has Been Previously Approved for Use by a Different Railroad AGENCY: Federal Railroad... processor-based signal or train control technology subject to the requirements of 49 CFR part 236, subpart H, in the situation where the railroad has not previously obtained FRA's approval to use the...

  11. 76 FR 63582 - Reporting Requirements for Positive Train Control Expenses and Investments

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-13

    ... Control Systems, 75 FR 2,598, 2,684 (Jan. 15, 2010). That estimate may decrease, as FRA has proposed an... implementation. Positive Train Control Systems, 76 FR 52,918 (Aug. 24, 2011). \\6\\ See UP's Pet. 2; A Primer for... information will help the Board to monitor the financing of PTC installation. \\10\\ See infra App. B,...

  12. 76 FR 23714 - Railroad Safety Appliance Standards

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-28

    ... Process. See 66 FR 4104, 4198 (January 17, 2001). To FRA's knowledge this requirement has not presented... technological advancements and ergonomic design standards for new ] car construction and ensuring that modern... railcar design that have occurred since the safety appliance regulations were promulgated in their...

  13. 76 FR 4276 - Hazardous Materials: Improving the Safety of Railroad Transportation of Hazardous Materials

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-25

    ... Transportation of Hazardous Materials AGENCY: Federal Railroad Administration (FRA), Department of Transportation... From the Federal Register Online via the Government Printing Office DEPARTMENT OF TRANSPORTATION... comments. Fax: 202-493-2251. Mail: Docket Operations Facility, U.S. Department of Transportation, 1200...

  14. Lunar Sample Compendium C Meyer 2011

    E-print Network

    Rathbun, Julie A.

    -25296. 14006 Crystalline-matrix Breccia 12.13 grams Figure 2: Map of Apollo 14 showing location of "contingency (figure 1). It is a breccia sample of the Fra Mauro type. Records show that Larry Nyquist breccia with 15-20% vugs and vesicles. The matrix is fine-grained with intergrown plagioclase

  15. Lunar Sample Compendium C Meyer 2011

    E-print Network

    Rathbun, Julie A.

    Breccia 600.2 grams #12;Lunar Sample Compendium C Meyer 2011 Mineral Clasts Lithic Clasts Glass Crystalline-Matrix-Breccias Apollo 14 CMB (Fra Mauro) Regolith breccias Light matrix breccia 14318 Figure 3: Location of 14318 on Apollo 14 traverse map. Figure 4: Simonds diagram for Apollo 14 breccias

  16. Lunar Sample Compendium C Meyer 2008

    E-print Network

    Rathbun, Julie A.

    Lunar Sample Compendium C Meyer 2008 14301 Regolith Breccia 1360.6 grams Mineral Clasts Lithic Clasts Glass Crystalline-Matrix-Breccias Apollo 14 CMB (Fra Mauro) Regolith breccias Light matrix breccia 14301 Figure 3: Ratio of clast abundance in Apollo 14 breccia samples with 14301 (Simonds et al. 1977

  17. Lunar Sample Compendium C Meyer 2011

    E-print Network

    Rathbun, Julie A.

    Lunar Sample Compendium C Meyer 2011 14307 Regolth Breccia 155 grams Figure 1: Photo of 14307. Sample is about 7 cm long. NASA S71-30361. Mineral Clasts Lithic Clasts Glass Crystalline-Matrix-Breccias Apollo 14 CMB (Fra Mauro) Regolith breccias Light matrix breccia 14307 14307 Figure 4: Traverse map

  18. 76 FR 78731 - Petition for Waiver of Compliance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-19

    ...2011, Drake Switching Company, LLC (DSC) has petitioned the Federal Railroad Administration...petition Docket Number FRA-2011-0015. DSC seeks a waiver of compliance from certain...SWX735), which is used as a locomotive. DSC states that this shuttlewagon is...

  19. 49 CFR Appendix C to Part 219 - Post-Accident Testing Specimen Collection

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Toxicological Testing (49 CFR part 219), describing the testing event and identifying the employees whose... Custody and Control Form (49 CFR part 219) (Form FRA F 6180.74 (revised)). 5. If required by the medical... employment (49 CFR 219.11). A private, controlled area should be designated for collection of specimens...

  20. 49 CFR Appendix C to Part 219 - Post-Accident Testing Specimen Collection

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Toxicological Testing (49 CFR part 219), describing the testing event and identifying the employees whose... Custody and Control Form (49 CFR part 219) (Form FRA F 6180.74 (revised)). 5. If required by the medical... employment (49 CFR 219.11). A private, controlled area should be designated for collection of specimens...

  1. 49 CFR Appendix C to Part 219 - Post-Accident Testing Specimen Collection

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Toxicological Testing (49 CFR part 219), describing the testing event and identifying the employees whose... Custody and Control Form (49 CFR part 219) (Form FRA F 6180.74 (revised)). 5. If required by the medical... employment (49 CFR 219.11). A private, controlled area should be designated for collection of specimens...

  2. 49 CFR Appendix C to Part 219 - Post-Accident Testing Specimen Collection

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Toxicological Testing (49 CFR part 219), describing the testing event and identifying the employees whose... Custody and Control Form (49 CFR part 219) (Form FRA F 6180.74 (revised)). 5. If required by the medical... employment (49 CFR 219.11). A private, controlled area should be designated for collection of specimens...

  3. 49 CFR Appendix C to Part 219 - Post-Accident Testing Specimen Collection

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Toxicological Testing (49 CFR part 219), describing the testing event and identifying the employees whose... Custody and Control Form (49 CFR part 219) (Form FRA F 6180.74 (revised)). 5. If required by the medical... employment (49 CFR 219.11). A private, controlled area should be designated for collection of specimens...

  4. 78 FR 22363 - Environmental Impact Statement for the All Aboard Florida Miami-Orlando Passenger Rail Project

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-15

    .... 4321 et seq.) (NEPA) and FRA's Procedures for Considering Environmental Impacts (64 FR 28545, May 26... Federal Railroad Administration Environmental Impact Statement for the All Aboard Florida Miami-- Orlando... service proposed by the private company, All Aboard Florida--Operations LLC (AAF), between Miami...

  5. 75 FR 80014 - Drivers of CMVs: Restricting the Use of Cellular Phones

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-21

    ... Management System published in the Federal Register on January 17, 2008 (73 FR 3316). II. Abbreviations AAMVA... Motor Carrier Safety Regulations FONSI Finding of No Significant Impact FR Federal Register FRA Federal... 31136(e) (Federal Motor Carrier Safety Regulations; General, 53 FR 18042-18043, 18053 (May 19, 1988)...

  6. 77 FR 64374 - Notification of Petition for Approval; Port Authority Trans-Hudson Product Safety Plan

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-19

    ...FRA-2012-0075] Notification of Petition for Approval; Port Authority Trans- Hudson Product Safety Plan In accordance with Part 236 of...that by a document dated September 5, 2012, Port Authority Trans-Hudson (PATH) has petitioned the Federal Railroad...

  7. On elliptic modular foliations Hossein Movasati1

    E-print Network

    Movasati, Hossein

    and their counterparts in holo- morphic foliations/differential equations. They are classified as transversely 12 t1, 1 12 t2, 2 3(12)2 t3), see [21], p. 4). We denote by F(Ra) the singular holo- morphic

  8. 12 CFR 308.3 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...and loan holding company or any subsidiary thereof (other than a bank) as those terms are defined in section 10(a) of the HOLA (12 U.S.C. 1467(a)); (4) Any organization operating under section 25 of the FRA (12 U.S.C. 601 et...

  9. 12 CFR 308.3 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...and loan holding company or any subsidiary thereof (other than a bank) as those terms are defined in section 10(a) of the HOLA (12 U.S.C. 1467(a)); (4) Any organization operating under section 25 of the FRA (12 U.S.C. 601 et...

  10. 49 CFR 238.423 - Fuel tanks.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Fuel tanks. 238.423 Section 238.423 Transportation....423 Fuel tanks. (a) External fuel tanks. Each type of external fuel tank must be approved by FRA's Associate Administrator for Safety upon a showing that the fuel tank provides a level of safety at...

  11. 49 CFR 238.423 - Fuel tanks.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false Fuel tanks. 238.423 Section 238.423 Transportation....423 Fuel tanks. (a) External fuel tanks. Each type of external fuel tank must be approved by FRA's Associate Administrator for Safety upon a showing that the fuel tank provides a level of safety at...

  12. 49 CFR 238.423 - Fuel tanks.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 4 2012-10-01 2012-10-01 false Fuel tanks. 238.423 Section 238.423 Transportation....423 Fuel tanks. (a) External fuel tanks. Each type of external fuel tank must be approved by FRA's Associate Administrator for Safety upon a showing that the fuel tank provides a level of safety at...

  13. 78 FR 32007 - Environmental Impact Statement for Tulsa-Oklahoma City Passenger Rail Corridor, Oklahoma, Lincoln...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-28

    ... implementing NEPA and the FRA's Procedures for Considering Environmental Impacts as set forth in 64 FR 28545...) for the State of Oklahoma High-Speed Rail Initiative: Tulsa--Oklahoma City Passenger Rail Corridor... currently has no passenger rail service. This corridor is part of the South Central High Speed Rail...

  14. 78 FR 22031 - California High-Speed Rail Authority-Construction Exemption-In Merced, Madera and Fresno Counties...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-12

    ... Surface Transportation Board California High-Speed Rail Authority--Construction Exemption--In Merced... Administration (FRA) and California High-Speed Rail Authority (Authority). This Final EIS is titled ``California High-Speed Train: Merced to Fresno Section, Final Project Environmental Impact...

  15. 76 FR 50323 - Notice of Availability of a Draft Environmental Impact Report/Environmental Impact Statement for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-12

    ... 1500 et seq.), FRA's Procedures for Considering Environmental Impacts (64 FR 28545 (May 26, 1999)), the.../ Environmental Impact Statement for the California High-Speed Train Project Fresno to Bakersfield Section AGENCY...)/Environmental Impact Statement (EIS) has been prepared for the California High-Speed Train (HST) Project...

  16. 75 FR 54694 - Notice of Availability of a Supplemental Draft Environmental Impact Statement for the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-08

    ... Considering Environmental Impacts (64 FR 28545; May 26, 1999). DesertXpress Enterprises Inc., the Project... Statement for the DesertXpress High-Speed Passenger Rail Project AGENCY: Federal Railroad Administration...- Speed Passenger Train Project (Project). FRA is the lead agency for the environmental review process...

  17. 77 FR 43902 - Notice of Availability of a Supplemental Draft Environmental Impact Statement for the California...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-26

    ... NEPA (40 CFR parts 1500 et seq.), and FRA's Procedures for Considering Environmental Impacts (64 FR... Statement for the California High-Speed Train Project Fresno to Bakersfield Section AGENCY: Federal Railroad... Statement (EIS) has been prepared for the Fresno to Bakersfield Section of the California High- Speed...

  18. 78 FR 57449 - Notice Rescinding a Notice of Intent To Prepare a Programmatic Environmental Impact Statement...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-18

    ... Environmental Impact Statement: High Speed Rail Corridor Las Vegas, Nevada to Anaheim, California AGENCY... and 2000s, the California- Nevada Super Speed Train Commission (CNSSTC), a public agency chartered... magnetic levitation ] technology high-speed ground transportation system. During the late 1990s, FRA...

  19. 78 FR 28940 - Environmental Impact Statement for the Atlanta to Charlotte Portion of the Southeast High Speed...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-16

    ... Southeast High Speed Rail Corridor AGENCY: Federal Rail Administration (FRA), DOT. ACTION: Notice of Intent... between Atlanta, GA and Charlotte, NC, along the Southeast High-Speed Rail Corridor (SEHSR) as designated by the USDOT. The Study is being advanced consistent with the federal High-Speed Intercity...

  20. 78 FR 70398 - Proposed Agency Information Collection Activities; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-25

    ... Federal agencies to issue two notices seeking public comment on information collection activities before... the agency was seeking OMB approval. 78 FR 56995. FRA received no comments in response to the... following collections of information was published on September 16, 2013 (78 FR 56995). DATES: Comments...

  1. 49 CFR 225.35 - Access to records and reports.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... correct the problem. Should a railroad assert a legal privilege with respect to certain claims and medical.... FRA retains the right to issue a subpoena to obtain such records under 49 U.S.C. §§ 20107 and 20902... Administration or of a State agency participating in investigative and surveillance activities under part 212...

  2. 49 CFR 225.35 - Access to records and reports.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... correct the problem. Should a railroad assert a legal privilege with respect to certain claims and medical.... FRA retains the right to issue a subpoena to obtain such records under 49 U.S.C. §§ 20107 and 20902... Administration or of a State agency participating in investigative and surveillance activities under part 212...

  3. 49 CFR 225.9 - Telephonic reports of certain accidents/incidents and other events.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Transportation Safety Board (49 CFR part 840) and the Research and Special Programs Administration of the U.S. Department of Transportation (Hazardous Materials Regulations, 49 CFR 171.15). FRA Locomotive Safety... number (800-424-0201). 49 CFR 229.17. (c) Contents of report. Each report must state the: (1) Name of...

  4. 76 FR 30855 - Accident/Incident Reporting Requirements

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-27

    ... accident/incident report (NTSB Recommendation Number RAR-05/02). See 75 FR 68891. However, upon further... NTSB Railroad Accident Report Number 05/02 (RAR 05/02). See 75 FR 68891. To clarify, FRA added Train... Equipment Accident/Incident Report.'' See 75 FR 68897. The codes represent the type of territory...

  5. 76 FR 75945 - Safety Advisory 2011-03

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-05

    ... prior to the accident, the worker had raised safety concerns with the safety manager for the general... Federal Railroad Administration Safety Advisory 2011-03 AGENCY: Federal Railroad Administration (FRA), Department of Transportation (DOT). ACTION: Notice of Safety Advisory; Bridge Walkway Hazards. SUMMARY:...

  6. 49 CFR 268.17 - Project selection criteria.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., DEPARTMENT OF TRANSPORTATION MAGNETIC LEVITATION TRANSPORTATION TECHNOLOGY DEPLOYMENT PROGRAM Procedures For... corridor or network that has been identified, by any State, group of States, or the FRA, as having... development status of the Maglev technology selected by the applicant for the project. (c) Benefits for...

  7. 77 FR 40700 - Notice of Application for Approval of Discontinuance or Modification of a Railroad Signal System

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-10

    ...Application for Approval of Discontinuance or Modification of a Railroad Signal System In accordance...seeking approval for the discontinuance or modification of a signal system. FRA assigned the...Operating Rules 6.21, when a severe weather event is encountered during the...

  8. 77 FR 2774 - Notice of Application for Approval of Discontinuance or Modification of a Railroad Signal System

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-19

    ...Application for Approval of Discontinuance or Modification of a Railroad Signal System In accordance...seeking approval for the discontinuance or modification of a signal system. FRA has reopened...out of service since being damaged by weather in December 2003. RBMN applied,...

  9. 75 FR 42476 - Petition for Waiver of Compliance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-21

    ... From the Federal Register Online via the Government Printing Office DEPARTMENT OF TRANSPORTATION Federal Railroad Administration Petition for Waiver of Compliance In accordance with Part 211 of Title 49 Code of Federal Regulations (CFR), notice is hereby given that the Federal Railroad Administration (FRA) has received a request for a waiver...

  10. 77 FR 40700 - Notice of Application for Approval of Discontinuance or Modification of a Railroad Signal System

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-10

    ... Federal Railroad Administration Notice of Application for Approval of Discontinuance or Modification of a...) seeking approval for the discontinuance or modification of a signal system. FRA assigned the petition... in General Code of Operating Rules 6.21, when a severe weather event is encountered during the...

  11. 77 FR 2774 - Notice of Application for Approval of Discontinuance or Modification of a Railroad Signal System

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-19

    ... Federal Railroad Administration Notice of Application for Approval of Discontinuance or Modification of a... for the discontinuance or modification of a signal system. FRA has reopened and assigned the... been out of service since being damaged by weather in December 2003. RBMN applied, in Docket Number...

  12. 75 FR 2597 - Positive Train Control Systems

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-15

    ..., Washington, DC 20590. Hand Delivery: Room W12-140 on the Ground level of the West Building, 1200 New Jersey... of alcohol and drug use in railroad operations, operational testing and inspection programs designed... control systems without impairing technological development. 70 FR 11,052 (Mar. 7, 2005). FRA...

  13. 49 CFR Appendix A to Part 214 - Schedule of Civil Penalties 1

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... to assess a penalty of up to $100,000 for any violation where circumstances warrant. See 49 CFR part... section numbers from 49 CFR part 214. If more than one item is listed as a type of violation of a given... citations will cite the CFR section and the penalty code, if any. FRA reserves the right, should...

  14. 76 FR 80781 - Alcohol and Drug Testing: Determination of Minimum Random Testing Rates for 2012

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-27

    ... Federal Railroad Administration 49 CFR Part 219 RIN 2130-AA81 Alcohol and Drug Testing: Determination of Minimum Random Testing Rates for 2012 AGENCY: Federal Railroad Administration (FRA), DOT. ACTION: Notice... random drug testing ] positive rate has remained below 1.0 percent for the last two years. The...

  15. 76 FR 57796 - Petition for Waiver of Compliance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-16

    ... railroad to pick up trains at Olmito Yard (in lieu of the interchange point at MP 4.48). On those occasions... relief permits trains transferred by Union Pacific Railroad (UP) (under Waiver Petition Docket Number FRA... (KCSM) at Brownsville, Texas) to move from BRG's interchange point with UP at Milepost (MP) 4.48 to...

  16. JB6 Mouse Model

    Cancer.gov

    JB6 References 2002 Young MR, Nair R, Bucheimer N, Tulsian P, Hsu T-C, & Colburn NH. Transactivation of Fra-1 and consequent activation of AP-1 occur Erk dependently. Mole Cell Biol 22: 587-598, 2002.  Abstract  Full Text    Liu G, Zhang Y, Bode AM, Ma WY

  17. 76 FR 16199 - Hours of Service of Railroad Employees; Substantive Regulations for Train Employees Providing...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-22

    ...FRA is proposing to amend its hours of service recordkeeping regulations, to establish hours of service regulations, including maximum on-duty periods, minimum off-duty periods, and other limitations, for train employees (e.g., locomotive engineers and conductors) providing commuter and intercity rail passenger transportation. The proposed regulations would require that railroads employing......

  18. 76 FR 34801 - Petition for Modification of Single Car Air Brake Test Procedures

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-14

    ... Federal Railroad Administration Petition for Modification of Single Car Air Brake Test Procedures In... air brake test procedures as prescribed in 49 CFR 232.305(a). FRA assigned the request Docket Number... straight air brake employed on PATH cars. The single car air brake test described in Association...

  19. 76 FR 67073 - Safety and Health Requirements Related to Camp Cars

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-31

    ... the hours of service laws at 49 U.S.C. 21106). See notice of proposed rulemaking (NPRM), 76 FR 64... the responsibility to carry out his responsibilities under RSIA to the Administrator of FRA. 74 FR... FR 30892 (July 27, 1990), codified at 49 CFR part 228, app. C. In developing new subpart E,...

  20. Apollo 14 Impact Glasses and Clementine Data: Implications for Regional Geology

    NASA Technical Reports Server (NTRS)

    Zellner, N. E. B.; Spudis, P. D.; Delano, J. W.; Whittet, D. C. B.

    2002-01-01

    Clementine color image data and analyses of 778 lunar impact glasses have been used together to suggest that the highlands of the Fra Mauro region consist of a KREEP-rich regolith overlying a feldspathic terrain. Low-KREEP impact glasses may possess a memory of impacts prior to 3.9 Ga ago. Additional information is contained in the original extended abstract.

  1. Intercity rail-passenger car ride quality test program

    NASA Technical Reports Server (NTRS)

    Scharr, R. L.; Owings, R. P.

    1975-01-01

    The Federal Railroad Administration's research and development program relating to intercity rail-passenger ride quality focuses on developing ride quality design criteria and specifications. The FRA ride quality test program and some of the techniques being used to analyze and evaluate the design criteria of the program are discussed.

  2. 49 CFR Appendix C to Part 222 - Guide to Establishing Quiet Zones

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... recommended to aid in the decision making process (http://www.fra.dot.gov/us/content/1337). The Quiet Zone... will require continued monitoring and analysis throughout the existence of the quiet zone to ensure... to provide the required Notice of Intent early in the quiet zone development process. The...

  3. 77 FR 22843 - Notice of Product Development

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-17

    ... From the Federal Register Online via the Government Printing Office DEPARTMENT OF TRANSPORTATION Federal Railroad Administration Notice of Product Development In accordance with Part 211 of Title 49 Code...) have provided the Federal Railroad Administration (FRA) a Notice of Product Development per 49 CFR...

  4. 76 FR 34683 - Withdrawal of Notices Inviting Applications for New Awards for Fiscal Year (FY) 2011...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-14

    ... Program. SUMMARY: On September 17, 2010 (75 FR 57000) (DDRA); October 1, 2010 (75 FR 60740) (FRA); January 13, 2011 (76 FR 2349) (BIE) and (76 FR 2353) (IRS); January 25, 2011 (76 FR 4330) (AORC); February 8, 2011 (76 FR 6769) (UISFL); and March 22, 2011 (76 FR 15956) (Comprehensive Program), the...

  5. 78 FR 7857 - Proposed Agency Information Collection Activities; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-04

    ...); see also 60 FR 44983, Aug. 29, 1995. The summary below describes the nature of the information... agency was seeking OMB approval. 77 FR 68203. FRA received one comment in response to this notice. On... also 60 FR 44978, 44983, Aug. 29, 1995. OMB believes that the 30 day notice informs the...

  6. 78 FR 65421 - Proposed Agency Information Collection Activities; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-31

    ... this ICR that the agency was seeking OMB approval. 78 FR 49321. FRA received no comments in response to....S.C. 3507 (b)-(c); 5 CFR 1320.12(d); see also 60 FR 44978, 44983, Aug. 29, 1995. OMB believes that... adequate time to digest public comments before it renders a decision. 60 FR 44983, Aug. 29, 1995....

  7. 78 FR 77601 - Adjustment of Monetary Threshold for Reporting Rail Equipment Accidents/Incidents for Calendar...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-24

    ... Procedures) (64 FR 28545 (May 26, 1999)) as required by the National Environmental Policy Act (42 U.S.C. 4321... 61 FR 60632 (Nov. 29, 1996). In 2005, FRA again amended its method for calculating the reporting... Surface Transportation Board for the BLS data that was no longer collected (70 FR 75414 (Dec. 20,...

  8. 77 FR 71354 - Adjustment of Monetary Threshold for Reporting Rail Equipment Accidents/Incidents for Calendar...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-30

    ...This rule increases the rail equipment accident/incident reporting threshold from $9,500 to $9,900 for certain railroad accidents/incidents involving property damage that occur during calendar year 2013. This action is needed to ensure that FRA's reporting requirements reflect cost increases that have occurred since the reporting threshold was last published in November of...

  9. 75 FR 75911 - Adjustment of Monetary Threshold for Reporting Rail Equipment Accidents/Incidents for Calendar...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-07

    ...This rule increases the rail equipment accident/incident reporting threshold from $9,200 to $9,400 for certain railroad accidents/incidents involving property damage that occur during calendar year 2011. This action is needed to ensure that FRA's reporting requirements reflect cost increases that have occurred since the reporting threshold was last computed in December of...

  10. 76 FR 72850 - Adjustment of Monetary Threshold for Reporting Rail Equipment Accidents/Incidents for Calendar...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-28

    ...This rule increases the rail equipment accident/incident reporting threshold from $9,400 to $9,500 for certain railroad accidents/incidents involving property damage that occur during calendar year 2012. This action is needed to ensure that FRA's reporting requirements reflect cost increases that have occurred since the reporting threshold was last published in December of...

  11. 75 FR 25927 - Vehicle/Track Interaction Safety Standards; High-Speed and High Cant Deficiency Operations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-10

    ... areas of railroad safety.'' See 36 FR 20336. FRA envisioned the new Standards to be an evolving set of... 63 FR 33992, which, effective September 21, 1998, revised the Track Safety Standards in their... standards for railroad passenger equipment. See 61 FR 30672. The ANPRM provided background information...

  12. 76 FR 26682 - Study on Protection of Certain Railroad Risk Reduction Data From Discovery or Use in Litigation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-09

    ... against them in litigation. See 49 U.S.C. 20156 and 75 FR 76345 (December 8, 2010), Docket No. FRA-2009... whether it is in the public interest, including public safety and the legal rights of persons injured in... the public interest (including public safety and the legal rights of persons injured in...

  13. 49 CFR 236.913 - Filing and approval of PSPs.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...provides the petitioner with a statement of reasons why the petition has not yet been approved. (e) What role do product users play in the process of safety review? (1) FRA will publish in the Federal Register periodically a topic list including...

  14. 78 FR 22025 - Petition for Waiver of Compliance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-12

    ... three oil-burning, Baldwin steam locomotives; one EMD ] GP9; and a Whitcomb center cab switch engine in...'s complete Privacy Act Statement in the Federal Register published on April 11, 2000 (65 FR 19477... regulations contained at 49 CFR part 230, Steam Locomotive Inspection and Maintenance Standards. FRA...

  15. 78 FR 16358 - Safety Advisory 2013-02; Low-Speed, Wheel-Climb Derailments of Passenger Equipment With “Stiff...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-14

    ...FRA is issuing Safety Advisory 2013-02 to alert railroads and other industry members about low-speed, wheel-climb derailments of certain passenger equipment designs having ``stiff'' suspension systems. These derailments have occurred when such equipment was negotiating track with a high degree of curvature and crosslevel variations (commonly referred to as ``track warp'') that were still......

  16. Cumulative effects of in utero administration of mixtures of "antiandrogens" on male rat reproductive development

    EPA Science Inventory

    Although risk assessments are typically conducted on a chemical-by-chemical basis, the 1996 Food Quality Protection Act requires the USEPA to consider cumulative risk of chemicals that act via a common mechanism of toxicity. To this end, we are conducting studies to provide a fra...

  17. 76 FR 64 - Safety and Health Requirements Related to Camp Cars

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-03

    ... his responsibilities under RSIA to the Administrator of FRA. 74 FR 26981, 26982, June 5, 2009... Guidelines for Clean, Safe, and Sanitary Railroad Provided Camp Cars (1990 Guidelines), 55 FR 30892, July 27... interrupt rest. Amendment to appendix A to 49 CFR part 228, 43 FR 30803, July 18, 1978. To carry out...

  18. Host-specific association between Flavobacterium columnare genomovars and fish species

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A total of 90 Flavobacterium columnare isolates were recovered from predominant wild fish species in the Mobile River, Alabama, USA. Isolates were identified and confirmed by fatty acid methyl ester analysis and specific PCR amplification. Genomovar ascription was performed using 16S-restriction fra...

  19. 520revision:1995-01-12modified:2001-10-21 ON INVARIANTS FOR 1-SEPARABLE GROUPS

    E-print Network

    Shelah, Saharon

    Ehrenfeucht-Fra¨iss´e games and prove a strong classification re- sult assuming PFA, and a strong non countable subset is contained in a free direct summand of the group. In particular, therefore, an 1-separable group is 1-free, i.e., every countable subgroup is free. The structure of 1-separable groups

  20. 75 FR 65707 - Notice Regarding Consideration and Processing of Applications for Financial Assistance Under the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-26

    ... Federal Register on September 29, 2010 (75 FR 60165) regarding consideration and processing of... published a notice in the Federal Register on September 29, 2010 (75 FR 60165) regarding FRA's consideration... Financial Assistance Under the Railroad Rehabilitation and Improvement Financing (RRIF) Program...

  1. 76 FR 8397 - Environmental Impact Statement for the Chicago, IL to St. Louis, MO High Speed Rail Program Corridor

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-14

    ... Impacts (64 FR 28545; May 26, 1999). The FRA and IDOT will ] use a tiered process, as provided for in 40... Federal Railroad Administration Environmental Impact Statement for the Chicago, IL to St. Louis, MO High...) will jointly prepare a Tier 1 Environmental Impact Statement (EIS) for the Chicago, IL to St. Louis,...

  2. 77 FR 69920 - Notice of Availability of a Final Tier 1 Environmental Impact Statement, for the Chicago, IL to...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-21

    ... 1500 et seq.), and FRA's Procedures for Considering Environmental Impacts (64 FR 28545; May 26, 1999..., for the Chicago, IL to St. Louis, MO High Speed Rail Corridor Program and Tier 2 Evaluation for the... (Final EIS) has been prepared for the Chicago, Illinois to St. Louis, Missouri High Speed Rail...

  3. 49 CFR 262.15 - Environmental assessment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Environmental Quality (40 CFR part 1500) and the Advisory Council on Historic Preservation Protection of Historic Properties regulation (36 CFR part 800) will govern FRA's compliance with applicable environmental... 49 Transportation 4 2010-10-01 2010-10-01 false Environmental assessment. 262.15 Section...

  4. 77 FR 35471 - National Environmental Policy Act Implementation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-13

    ... complete Privacy Act Statement in the Federal Register published on April 11, 2000 (65 FR 19477), or visit... Register on May 26, 1999 (64 FR 28545) and are available on the agency's Web site at http://www.fra.dot.gov... Federal Railroad Administration National Environmental Policy Act Implementation AGENCY: Federal...

  5. 49 CFR 260.35 - Environmental assessment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Council on Environmental Quality (“CEQ Regulation”) (40 CFR Part 1500) will govern the FRA's compliance... 49 Transportation 4 2010-10-01 2010-10-01 false Environmental assessment. 260.35 Section 260.35... REHABILITATION AND IMPROVEMENT FINANCING PROGRAM Applications for Financial Assistance § 260.35...

  6. 77 FR 21311 - Locomotive Safety Standards

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-09

    ... systems since the Locomotive Safety Standards regulation was first published in 1980. See 45 FR 21092. The... systems, subsystems, and components including requirements to ensure that the development, installation... safety analysis for new locomotive electronic systems. FRA believes this final rule will modernize...

  7. 76 FR 4250 - Operating Certain Railroad Tank Cars in Excess of 263,000 Pounds Gross Rail Load; Approval

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-25

    ... record. 75 FR 27205 (Final Rule). The Final Rule titled, Hazardous Materials: Incorporation of Special... hazardous materials such as PIH materials (HM-246; 74 FR 1770 (Jan. 13, 2009) (the ``Tank Car Rule'')), FRA... implement a crashworthiness performance standard as discussed in the Tank Car Rule. See 74 FR at 1771....

  8. Urban rats or flying heroes? What can rock pigeons tell us about helminth and virus co-infection?

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Emerging diseases are rapidly becoming a global conservation issue, and traditional approaches to understanding transmission among in-situ populations often involved investigating hosts in the context of a single pathogen. Yet it is clear now that understanding disease dynamics within ecological fra...

  9. Focal Retrograde Amnesia: Voxel-Based Morphometry Findings in a Case without MRI Lesions

    PubMed Central

    Sehm, Bernhard; Frisch, Stefan; Thöne-Otto, Angelika; Horstmann, Annette; Villringer, Arno; Obrig, Hellmuth

    2011-01-01

    Focal retrograde amnesia (FRA) is a rare neurocognitive disorder presenting with an isolated loss of retrograde memory. In the absence of detectable brain lesions, a differentiation of FRA from psychogenic causes is difficult. Here we report a case study of persisting FRA after an epileptic seizure. A thorough neuropsychological assessment confirmed severe retrograde memory deficits while anterograde memory abilities were completely normal. Neurological and psychiatric examination were unremarkable and high-resolution MRI showed no neuroradiologically apparent lesion. However, voxel-based morphometry (VBM)-comparing the MRI to an education-, age-and sex-matched control group (n?=?20) disclosed distinct gray matter decreases in left temporopolar cortex and a region between right posterior parahippocampal and lingual cortex. Although the results of VBM-based comparisons between a single case and a healthy control group are generally susceptible to differences unrelated to the specific symptoms of the case, we believe that our data suggest a causal role of the cortical areas detected since the retrograde memory deficit is the preeminent neuropsychological difference between patient and controls. This was paralleled by grey matter differences in central nodes of the retrograde memory network. We therefore suggest that these subtle alterations represent structural correlates of the focal retrograde amnesia in our patient. Beyond the implications for the diagnosis and etiology of FRA, our results advocate the use of VBM in conditions that do not show abnormalities in clinical radiological assessment, but show distinct neuropsychological deficits. PMID:22028902

  10. 49 CFR 238.423 - Fuel tanks.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false Fuel tanks. 238.423 Section 238.423 Transportation....423 Fuel tanks. (a) External fuel tanks. Each type of external fuel tank must be approved by FRA's Associate Administrator for Safety upon a showing that the fuel tank provides a level of safety at...

  11. 49 CFR 238.423 - Fuel tanks.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Fuel tanks. 238.423 Section 238.423 Transportation....423 Fuel tanks. (a) External fuel tanks. Each type of external fuel tank must be approved by FRA's Associate Administrator for Safety upon a showing that the fuel tank provides a level of safety at...

  12. 77 FR 74736 - Notice of Application for Approval of Discontinuance or Modification of a Railroad Signal System

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-17

    ... Railroad Signal System In accordance with Part 235 of Title 49 Code of Federal Regulations (CFR) and Title...) seeking approval for the discontinuance or modification of a signal system. FRA assigned the petition... signal system without wayside signals on the NS Pittsburgh Line, from Harrisburg, Milepost (MP) PT...

  13. De fleste har vel n ftt med seg at Foreleserprisen ved

    E-print Network

    Avlesen, Helge

    for 2009/10 er gått til vår egen Andreas Leopold Knutsen. Jeg slutter meg til ordene fra Stein Arild: "Det Andreas Leopold med årets foreleserpris! Jarle Berntsen Instituttleder Vet du om noe matematikkrelatert mottok pris og heder Førsteamanuensis Andreas Leopold Knutsen ble den femte i rekken av ansatte ved

  14. 49 CFR 240.215 - Retaining information supporting determinations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... controls those who have access to such information; (2) The railroad employs a system for data storage that... by FRA representatives; and (3) Information retrieved from the system can be easily produced in a... during normal business hours. (i) It shall be unlawful for any railroad to knowingly or any individual...

  15. 76 FR 11569 - Hazardous Materials: Enhanced Enforcement Authority Procedures

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-02

    ...DGAC supports the concept of one place to appeal an emergency order. In addition, DGAC...emergency order. There is also a defined appeal process in Sec. Sec. 109.17 and 109...rule, FRA's regulations provide an appeal process for any party to whom a...

  16. 77 FR 65935 - Notice of Application for Approval of Discontinuance or Modification of a Railroad Signal System

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-31

    ... Railroad Signal System In accordance with Part 235 of Title 49 Code of Federal Regulations (CFR) and 49 U.S... approval for the discontinuance or modification of a signal system. FRA assigned the petition Docket Number... automatic signals within traffic control signal (TCS) territory and the installation of a cab signal...

  17. 49 CFR 230.48 - Number and capacity.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Number and capacity. 230.48 Section 230.48... Safety Relief Valves § 230.48 Number and capacity. (a) Number and capacity. Every boiler shall be.... An FRA inspector may require verification of sufficient safety valve relieving capacity....

  18. 49 CFR 214.503 - Good-faith challenges; procedures for notification and resolution.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...SAFETY On-Track Roadway Maintenance Machines and Hi-Rail Vehicles § 214.503...operating an on-track roadway maintenance machine or hi-rail vehicle shall inform the...a good-faith determination that the machine or vehicle does not comply with FRA...

  19. 49 CFR 214.503 - Good-faith challenges; procedures for notification and resolution.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...SAFETY On-Track Roadway Maintenance Machines and Hi-Rail Vehicles § 214.503...operating an on-track roadway maintenance machine or hi-rail vehicle shall inform the...a good-faith determination that the machine or vehicle does not comply with FRA...

  20. 49 CFR 214.503 - Good-faith challenges; procedures for notification and resolution.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...SAFETY On-Track Roadway Maintenance Machines and Hi-Rail Vehicles § 214.503...operating an on-track roadway maintenance machine or hi-rail vehicle shall inform the...a good-faith determination that the machine or vehicle does not comply with FRA...

  1. 76 FR 50320 - Proposed Agency Information Collection Activities; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-12

    ... systems. The revisions are designed to provide for and encourage the safe implementation and use of ECT... brake system technology. The collection of information is used by FRA to monitor and enforce current... related to ECP brake systems. The collection of information is also used by locomotive engineers and...

  2. 49 CFR 213.57 - Curves; elevation and speed limitations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... railroad shall transmit the results of the testing specified in paragraph (d) of this section to FRA's... condition under which the testing was performed, and description of the instrumentation used to qualify the... observed during testing; and 4 The test procedure may be conducted whereby all the wheels on one...

  3. 49 CFR 213.329 - Curves; elevation and speed limitations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... which the testing was performed, and description of the instrumentation used to qualify the vehicle type... results of the testing specified in paragraph (d) of this section to FRA's Associate Administrator for... during testing; and 9 The test procedure may be conducted whereby all the wheels on one side (right...

  4. 49 CFR 213.333 - Automated vehicle-based inspection systems.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... section, a vehicle having dynamic response characteristics that are representative of other vehicles... section. Based on a review of the report, FRA may require that an instrumented vehicle having dynamic.... Testing shall be conducted at the frequencies specified in paragraphs (j)(1) through (3) of this...

  5. 49 CFR 213.333 - Automated vehicle-based inspection systems.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... section, a vehicle having dynamic response characteristics that are representative of other vehicles... section. Based on a review of the report, FRA may require that an instrumented vehicle having dynamic.... Testing shall be conducted at the frequencies specified in paragraphs (j)(1) through (3) of this...

  6. 49 CFR 213.57 - Curves; elevation and speed limitations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... railroad shall transmit the results of the testing specified in paragraph (d) of this section to FRA's... condition under which the testing was performed, and description of the instrumentation used to qualify the... observed during testing; and 4 The test procedure may be conducted whereby all the wheels on one...

  7. 49 CFR 213.329 - Curves; elevation and speed limitations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... which the testing was performed, and description of the instrumentation used to qualify the vehicle type... results of the testing specified in paragraph (d) of this section to FRA's Associate Administrator for... during testing; and 9 The test procedure may be conducted whereby all the wheels on one side (right...

  8. Third Lunar Science Conference.

    NASA Technical Reports Server (NTRS)

    Burlingame, A.; Burnett, D.; Doe, B.; Gault, D.; Haskin, L.; Schnoes, H.; Heymann, D.; Melson, W.; Papike, J.; Tilling, R.

    1972-01-01

    Discussion of the nature and properties of lunar rock as deduced from the examination of Apollo lunar rock samples. The topics include the lunar crust, the Fra Mauro formation, the interior of the moon, lunar chronology, surface processes, and earth-moon environment.

  9. L'Internet-dipendenza aumenta l'impulsivit I risultati di uno studio coordinato dall'Universit degli Studi di Milano, con Swansea University e

    E-print Network

    Olivares, Stefano

    relazione fra Internet addiction, depressione e impulsività, in modo da produrre un quadro globale degli'ulteriore validazione del costrutto di Internet Addiction Disorder, suggeriscono che gli individui con dipendenza daL'Internet-dipendenza aumenta l'impulsività I risultati di uno studio coordinato dall

  10. Synergi i den regionale fdevarkonomi -hvad det offentlige kan gre

    E-print Network

    Schwefel, Hans-Peter

    . Dette sker via en kost registrering som plejepersonale kan foretage på PC 6. Pkt 5 kan evt foreages af patient via tablet evt pårørende 7. Opfølgning (daglig kost regeistering vil evt kunne ske med ipad efter hjemsendelse (evt med hjælp fra praktiserende læge) #12;Smarte Regional fødevare kæder 10 gode råde 1. Både

  11. 49 CFR Appendix C to Part 218 - Statement of Agency Enforcement Policy on Tampering

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... similar contexts. (See 49 CFR 107.299, defining “knowingly” under the Hazardous Materials Transportation... operating. Also, unlike the case where willfulness must be shown (see FRA's statement of policy at 49 CFR...) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD OPERATING PRACTICES Pt. 218, App....

  12. 49 CFR 219.607 - Railroad random alcohol testing programs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Railroad random alcohol testing programs. 219.607... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION CONTROL OF ALCOHOL AND DRUG USE Random Alcohol and Drug Testing Programs § 219.607 Railroad random alcohol testing programs. (a) Each railroad must submit for FRA...

  13. Genetic diversity, population structure and genome-wide marker-trait association analysis of the USDA pea (Pisum sativum L.) core collection

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Genetic diversity, population structure and genome-wide marker-trait association analysis was conducted for the USDA pea (Pisum sativum L.) core collection. The core collection contained 285 accessions with diverse phenotypes and geographic origins. The 137 DNA markers included 102 polymorphic fra...

  14. 76 FR 41555 - Tupelo, Mississippi Railroad Relocation Project

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-14

    ... Environmental Quality NEPA implementing regulations, 40 CFR Parts 1500-1508, and the FRA NEPA procedures, 64 FR... Federal Railroad Administration Tupelo, Mississippi Railroad Relocation Project AGENCY: Federal Railroad... Environmental Impact Statement and public hearing for the Tupelo, Mississippi Railroad Relocation...

  15. 49 CFR 230.33 - Welded repairs and alterations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...required thickness as required by this part. (d) Flush patches. The steam locomotive owner and/or operator shall submit...the FRA Regional Administrator for the installation of flush patches of any size on unstayed portions of the boiler. (e)...

  16. 49 CFR 230.33 - Welded repairs and alterations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...required thickness as required by this part. (d) Flush patches. The steam locomotive owner and/or operator shall submit...the FRA Regional Administrator for the installation of flush patches of any size on unstayed portions of the boiler. (e)...

  17. 49 CFR 230.33 - Welded repairs and alterations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...required thickness as required by this part. (d) Flush patches. The steam locomotive owner and/or operator shall submit...the FRA Regional Administrator for the installation of flush patches of any size on unstayed portions of the boiler. (e)...

  18. 49 CFR 230.33 - Welded repairs and alterations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...required thickness as required by this part. (d) Flush patches. The steam locomotive owner and/or operator shall submit...the FRA Regional Administrator for the installation of flush patches of any size on unstayed portions of the boiler. (e)...

  19. 78 FR 9845 - Minimum and Ordinary Maximum and Aggravated Maximum Civil Monetary Penalties for a Violation of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-12

    ...laws at 49 U.S.C. ch. 51 (Federal hazmat laws) or a regulation, order, special...or approval issued under the Federal hazmat laws (including the regulations at 49...manner in which FRA generally begins its hazmat penalty assessment process and the...

  20. 75 FR 27053 - Railroad Safety Advisory Committee; Charter Renewal

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-13

    ....gov/ . Please refer to the notice published in the Federal Register on March 11, 1996, 61 FR 9740, for... Federal Railroad Administration Railroad Safety Advisory Committee; Charter Renewal AGENCY: Federal... of the Railroad Safety Advisory Committee (RSAC). SUMMARY: FRA announces the charter renewal of...

  1. 75 FR 25927 - Vehicle/Track Interaction Safety Standards; High-Speed and High Cant Deficiency Operations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-10

    ... 75 FR 1180). Another task force, the Emergency Preparedness Task Force, was established to identify... February 1, 2008 (see 73 FR 6370). The fourth task force, the Track/Vehicle Interaction Task Force (also... areas of railroad safety.'' See 36 FR 20336. FRA envisioned the new Standards to be an evolving set...

  2. 78 FR 16051 - Vehicle/Track Interaction Safety Standards; High-Speed and High Cant Deficiency Operations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-13

    ... 75 FR 1180). Another task force, the Emergency Preparedness Task Force, was established to identify... February 1, 2008 (see 73 FR 6370). The fourth task force, the Track/Vehicle Interaction Task Force (also... vehicle/track interaction safety, see 75 FR 25928, FRA issues this final rule amending the Track...

  3. 75 FR 59579 - Restrictions on Railroad Operating Employees' Use of Cellular Telephones and Other Electronic...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-27

    ... electronic devices by railroad operating employees. 75 FR 27672 (May 18, 2010). The NPRM proposed to codify many of the requirements of Emergency Order 26 (Order or EO 26, 73 FR 58702 (Oct. 7, 2008)), but... telephones and other electronic devices while on duty. (73 FR 58702, Oct. 7, 2008). This FRA action was...

  4. 49 CFR 216.15 - Special notice for repairs-track class.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... false Special notice for repairs-track class. 216.15 Section 216.15...AND EMERGENCY ORDER PROCEDURES: RAILROAD TRACK, LOCOMOTIVE AND EQUIPMENT Special Notice...216.15 Special notice for repairs—track class. (a) When an FRA Track...

  5. 49 CFR 216.15 - Special notice for repairs-track class.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... false Special notice for repairs-track class. 216.15 Section 216.15...AND EMERGENCY ORDER PROCEDURES: RAILROAD TRACK, LOCOMOTIVE AND EQUIPMENT Special Notice...216.15 Special notice for repairs—track class. (a) When an FRA Track...

  6. 75 FR 61562 - Petition for Waiver of Compliance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-05

    ... From the Federal Register Online via the Government Printing Office DEPARTMENT OF TRANSPORTATION Federal Railroad Administration Petition for Waiver of Compliance In accordance with part 211 of Title 49 Code of Federal Regulations (CFR), notice is hereby given that the Federal Railroad Administration (FRA) has received a request for a waiver...

  7. 49 CFR 229.55 - Piston travel.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Piston travel. (a) Brake cylinder piston travel shall be sufficient to provide brake shoe clearance when the brakes are released. (b) When the brakes are applied on a standing locomotive, the brake cylinder... piston travel for each locomotive shall be entered on Form FRA F 6180-49A. (c) The minimum brake...

  8. 75 FR 65398 - Petition for Waiver of Compliance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-22

    ... published on April 11, 2000 (65 FR 19477) or at http://www.dot.gov/privacy.html . Issued in Washington, DC... relief. Canadian Pacific Railway The Canadian Pacific Railway (CP) hereby petitions FRA for a temporary... measurement system. Over the course of 6 months, CP intends to test the new system on their Northeast...

  9. 78 FR 48766 - Petition for Waiver of Compliance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-09

    ... to extraterritorial dispatching contained in FRA's interim final rule (see 66 FR 63942, December 11...'s complete Privacy Act Statement in the Federal Register published on April 11, 2000 (65 FR 19477... June 24, 2013, Canadian Pacific Railway (CP) has petitioned the Federal Railroad Administration...

  10. 75 FR 76778 - Environmental Impact Statement for the Milwaukee, WI (Milwaukee Intermodal Station) to...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-09

    ... Procedures for Considering Environmental Impacts (64 FR 28545; May 26, 1999). FRA, with Mn/DOT and WisDOT... Canadian Pacific Railway (CP) right-of-way from Milwaukee, WI to Watertown, WI; right-of-way owned by the... Madison, WI; CP right-of-way from Johnson Street Yard in Madison through Portage, WI and La Crosse, WI...

  11. 49 CFR Appendix A to Part 239 - Schedule of Civil Penalties 1

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., 21304, and 49 CFR part 209, appendix A. Further designations, not found in the CFR citation for certain provisions, are FRA Office of Chief Counsel computer codes added as a suffix to the CFR citation and used to... necessary, to substitute in its complaint the CFR citation in place of the combined designation cited in...

  12. 78 FR 47486 - Joint Failure on Continuous Welded Rail Track

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-05

    ... Federal Railroad Administration Joint Failure on Continuous Welded Rail Track AGENCY: Federal Railroad..., internal continuous welded rail (CWR) plans and properly inspecting CWR joints to identify and correct locations that indicate potential joint failure that may cause a derailment. FRA is issuing this notice...

  13. 49 CFR 227.5 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... the meaning assigned by the regulations of the Surface Transportation Board (49 CFR part 120; General... this part. Exchange rate means the change in sound level, in decibels, which would require halving or... exchange rate is 5 decibels. FRA means the Federal Railroad Administration. Hearing protector means...

  14. 49 CFR 1106.2 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Administration at 49 CFR 244.9, means the migration, combination, or unification of one set of railroad... meaning assigned by the Board's regulations (49 CFR part 1201; General Instructions 1-1), as those... Act and Board's environmental rules at 49 CFR part 1105. Federal Railroad Administration (“FRA”)...

  15. 49 CFR 1106.2 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Administration at 49 CFR 244.9, means the migration, combination, or unification of one set of railroad... meaning assigned by the Board's regulations (49 CFR part 1201; General Instructions 1-1), as those... Act and Board's environmental rules at 49 CFR part 1105. Federal Railroad Administration (“FRA”)...

  16. 78 FR 26693 - Proposed Agency Information Collection Activities; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-07

    ... review and comment. The ICRs describes the nature of the information collections and their expected... OMB approval. See 78 FR 11948. FRA received no comments after issuing this notice. Accordingly, these... after the 30 day notice is published. 44 U.S.C. 3507(b)-(c); 5 CFR 1320.12(d); see also 60 FR...

  17. 78 FR 16357 - Proposed Agency Information Collection Activities; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-14

    ...); see also 60 FR 44983, Aug. 29, 1995. The summary below describes the nature of the information... and comment. The ICR describes the nature of the information collection and their expected burden. The... OMB approval. 77 FR 77181. FRA received no comments in response to this notice. Before OMB...

  18. A k t u e l N a t u r v i d e n s k a b | 3 | 2 0 0 0 05-07-00 02.18

    E-print Network

    Emmeche, Claus

    kendte model er paradigme- modellen, som går tilbage til fysikhistorikeren Thomas Kuhns berømte værk fra 1962 (The structure of scientific revo- lutions). Ifølge Kuhns model foregår det meste forskning som- lisering til at blive en god for- sker, der ifølge Kuhn nødven- digvis må indeholde et element af

  19. 77 FR 23159 - Locomotive Safety Standards; Correction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-18

    ... rule related to locomotive safety standards. See 77 FR 21312. The final rule established a public... safety standards and comments on such petitions. That final rule mistakenly lists FR-2009- 0095... is FRA-2009-0094. The final rule issued on April 9, 2012, incorrectly identified docket number...

  20. 49 CFR 1106.2 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Administration at 49 CFR 244.9, means the migration, combination, or unification of one set of railroad... meaning assigned by the Board's regulations (49 CFR part 1201; General Instructions 1-1), as those... Act and Board's environmental rules at 49 CFR part 1105. Federal Railroad Administration (“FRA”)...

  1. 75 FR 36551 - State Highway-Rail Grade Crossing Action Plans

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-28

    ... Action Plans as a direct final rule in the Federal Register on September 2, 2009 (74 FR 45336). FRA... Executive Order 12866 and DOT policies and procedures (44 FR 11034; Feb. 26, 1979). The ten States... the railroad revenue deflator adjustment.\\3\\ \\2\\ See 68 FR 24891 (May 9, 2003). \\3\\ For...

  2. 75 FR 1179 - Passenger Equipment Safety Standards; Front End Strength of Cab Cars and Multiple-Unit Locomotives

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-08

    ... comprehensive safety standards for railroad passenger equipment. See 61 FR 30672. The ANPRM provided background... equipment. See 62 FR 49728. In addition to requesting written comment on the NPRM, FRA also solicited oral... was published on May 12, 1999. See 64 FR 25540. After publication of the final rule,...

  3. Characterizing wool keratin

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Keratin from wool is a reactive, biocompatible, and biodegradable material. Efficient alkaline extractions gave yields of 68% to 82% protein within 2 to 5 hours of exposure at 65 ºC. The water soluble keratin preparations contained intermediate filament and microfibrillar component-proteins of fra...

  4. 75 FR 16552 - High-Speed Intercity Passenger Rail (HSIPR) Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-01

    ... is a unique nine-digit sequence recognized as the universal standard for identifying and keeping... 23, 2009 interim program guidance (74 FR 29900), and details the application requirements and... grants program, please contact the FRA HSIPR Program Manager via e-mail at HSIPR@dot.gov , or by mail:...

  5. A Publication of the U.S. Department of Education's Higher Education Center for Alcohol and

    E-print Network

    Royer, Dana

    drinking problems. Encouraging more older students to live on campus and in fra- ternity houses may be one Drug Abuse and Violence Prevention CATALYST Diversity on Campus Implications for Prevention Spring 2007 from different cultures, backgrounds, and nationalities all come to the campus with different

  6. 78 FR 16036 - Service Level Environmental Impact Statement for the Texas Oklahoma Passenger Rail Study Corridor...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-13

    ... 64 FR 28545 dated May 26, 1999 (Environmental Procedures). The Service Level EIS will also address... Procedures (78 FR 2713; January 14, 2013). FRA and TxDOT will use a tiered process, as provided for in 40 CFR... Passenger Rail Study Corridor, South Texas to Oklahoma City AGENCY: Federal Railroad Administration...

  7. 75 FR 61386 - Emergency Escape Breathing Apparatus Standards

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-05

    ... this section of the RSIA to the Administrator of FRA. 74 FR 26981, 26982, June 5, 2009, 49 CFR 1.49(oo.... See 73 FR 75207, December 10, 2008, re Docket No. HHS-OS-2009-0025 at http://www.regulations.gov . The... respirators are supplied. See also 74 FR 23815, May 21, 2009, which reopened the comment period until...

  8. 77 FR 153 - Passenger Train Emergency Systems II

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-03

    ... Preparedness (PTEP) final rule. See 63 FR 24629. The rule contains minimum Federal safety standards for the... rule. See 64 FR 25540. This rule established comprehensive safety standards for railroad passenger... Register. See 65 FR 41284; 67 FR 19970; and 67 FR 42892. On February 1, 2008, FRA published a final rule...

  9. Esame Scritto, Modulo di Fisica, Corso di Chimica e Fisica Generali, per Biotecnologie 18 Febbraio 2014

    E-print Network

    Giannozzi, Paolo

    .2 m/s. Si assume che il rendimento dell'impianto, ovvero il rapporto fra energia prodotta ed energia corrente che fluisce attraverso la batteria; 2. la carica sulle armature del condensatore; 3. l'energia'acqua cade da un'altezza h, acquistando quindi un'energia cinetica mV 2 /2 = mv2 /2 + mgh, come si ricava

  10. A multiplex PCR assay for determination of mating type in isolates of the honey bee fungal pathogen, Ascosphaera apis.

    Technology Transfer Automated Retrieval System (TEKTRAN)

    In this study we developed a multiplex PCR for identification of mating type idiomorphs in the filamentous fungus, Ascosphaera apis, the causative agent of chalkbrood disease in the honey bee (Apis melliffera). A combination of gene-specific primers was designed to amplify Mat1-1 and Mat1-2 gene fra...

  11. Automated riverine landscape characterization: GIS-based tools for watershed-scale research, assessment, and management

    EPA Science Inventory

    River systems consist of hydrogeomorphic patches (HPs) that emerge at multiple spatiotemporal scales. Functional process zones (FPZs) are HPs that exist at the river valley scae and are important strata for fraing whole-watershed research questions and management plans. Hierarchi...

  12. 49 CFR 225.23 - Joint operations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Joint operations. 225.23 Section 225.23....23 Joint operations. (a) Any reportable death, injury, or illness of an employee arising from an accident/incident involving joint operations must be reported on Form FRA F 6180.55a by the...

  13. 49 CFR 225.23 - Joint operations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false Joint operations. 225.23 Section 225.23....23 Joint operations. (a) Any reportable death, injury, or illness of an employee arising from an accident/incident involving joint operations must be reported on Form FRA F 6180.55a by the...

  14. 49 CFR 225.23 - Joint operations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Joint operations. 225.23 Section 225.23....23 Joint operations. (a) Any reportable death, injury, or illness of an employee arising from an accident/incident involving joint operations must be reported on Form FRA F 6180.55a by the...

  15. 49 CFR 225.23 - Joint operations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false Joint operations. 225.23 Section 225.23....23 Joint operations. (a) Any reportable death, injury, or illness of an employee arising from an accident/incident involving joint operations must be reported on Form FRA F 6180.55a by the...

  16. Time course of tonal frequency-response-area of primary auditory cortex neurons in alert cats.

    PubMed

    Qin, Ling; Kitama, Toshihiro; Chimoto, Sohei; Sakayori, Shuichi; Sato, Yu

    2003-06-01

    Cells in the A1 auditory cortex of alert animals show various response time-courses during pure-tone stimuli: tonic, phasic-tonic, and phasic. Previously the time course of the spike firing rates was examined at a characteristic frequency (CF) or in a range of frequencies including CF. We investigated time-course of the frequency-response-area (FRA) during pure-tone stimuli in A1 cells of alert cats. The short rise/fall time (0.1-2 ms) and long stimulus duration (0.5 s) was used for investigation of the time course. FRA changed with time drastically in the phasic cells, mildly in the phasic-tonic cells, but not in the tonic cells. The best-response frequency (BF) within FRA was constant throughout the stimulus duration in the tonic and phasic-tonic cells, but was difficult to define in the phasic cells. The phasic firing properties of the phasic cells were preserved even during the bandnoise stimuli at various bandwidth and spectral locations. The variability of FRA time-course between cell types may play a role for analyzing auditory spectral cues that vary with a wide range of time constant. PMID:12767477

  17. 77 FR 58439 - Environmental Impact Statement for the Northeast Corridor Between Washington, DC, New York, NY...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-20

    ... Washington, DC, New York, NY and Boston, MA AGENCY: Federal Railroad Administration (FRA), Department of... W12-140, Washington, DC 20590-0001, by hand delivery to West Building Ground Floor, Room W12-140, 1200 New Jersey Ave. SE., Washington, DC (between 9 a.m. and 5 p.m. ET, Monday through Friday,...

  18. 77 FR 55265 - Environmental Impact Statement for the Northeast Corridor Between Washington, DC, New York, NY...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-07

    ... Washington, DC, New York, NY, and Boston, MA AGENCY: Federal Railroad Administration (FRA), U.S. Department... potential passenger rail improvements between Washington, DC, New York City, and Boston, MA was published in... Scoping meetings held from August 13th through August 22nd at nine different venues between Washington,...

  19. MODELING OF SPINEL SETTLING IN WASTE GLASS MELTER

    EPA Science Inventory

    The topic of this multi-institutional bi-national research is the formation and settling of spinel, the most common crystalline phase that precipitates in molten high-level waste HLW) glass. For the majority of HLW streams, spinel formation in the HLW melter limits the waste fra...

  20. COLGIO DE APLICAO / CED / UFSC LISTA DE PROFESSORES 2015/1

    E-print Network

    Hanazaki, Natalia

    Catarina Simas Ulbricht SSE 6º AO 9º ulbricht@terra.com.br Alana Godoy Lacava (Subst.) MAT 7AC 8ABC. ESPECIAL 1B cassiachala@yahoo.com.br Celina Maria Ramos Arruda LE - FRA 6ABC 7ABC 8ABC 9ABC 1ABCD 2ABCD 3

  1. 49 CFR 225.41 - Suicide data.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false Suicide data. 225.41 Section 225.41 Transportation... TRANSPORTATION RAILROAD ACCIDENTS/INCIDENTS: REPORTS CLASSIFICATION, AND INVESTIGATIONS § 225.41 Suicide data. FRA does not include suicide data (as defined in § 225.5) in its periodic summaries of data on...

  2. 49 CFR 225.41 - Suicide data.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 4 2012-10-01 2012-10-01 false Suicide data. 225.41 Section 225.41 Transportation... TRANSPORTATION RAILROAD ACCIDENTS/INCIDENTS: REPORTS CLASSIFICATION, AND INVESTIGATIONS § 225.41 Suicide data. FRA does not include suicide data (as defined in § 225.5) in its periodic summaries of data on...

  3. 49 CFR 225.41 - Suicide data.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Suicide data. 225.41 Section 225.41 Transportation... TRANSPORTATION RAILROAD ACCIDENTS/INCIDENTS: REPORTS CLASSIFICATION, AND INVESTIGATIONS § 225.41 Suicide data. FRA does not include suicide data (as defined in § 225.5) in its periodic summaries of data on...

  4. 49 CFR 225.41 - Suicide data.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false Suicide data. 225.41 Section 225.41 Transportation... TRANSPORTATION RAILROAD ACCIDENTS/INCIDENTS: REPORTS CLASSIFICATION, AND INVESTIGATIONS § 225.41 Suicide data. FRA does not include suicide data (as defined in § 225.5) in its periodic summaries of data on...

  5. 49 CFR Appendix A to Part 237 - Supplemental Statement of Agency Policy on the Safety of Railroad Bridges

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... FRA in 2000 as Appendix C of the Federal Track Safety Standards, 49 CFR Part 213. With the promulgation of 49 CFR Part 237, Bridge Safety Standards, many of the non-regulatory provisions in that Policy... bridges should be aware of the risks posed by earthquakes in the areas in which their bridges are...

  6. 49 CFR Appendix A to Part 237 - Supplemental Statement of Agency Policy on the Safety of Railroad Bridges

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... FRA in 2000 as Appendix C of the Federal Track Safety Standards, 49 CFR Part 213. With the promulgation of 49 CFR Part 237, Bridge Safety Standards, many of the non-regulatory provisions in that Policy... bridges should be aware of the risks posed by earthquakes in the areas in which their bridges are...

  7. 78 FR 58829 - Second Interim Statement of Agency Policy and Interpretation on the Hours of Service Laws as...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-24

    ... Amended; Response to Public Comment'' published at 77 FR 12408-31 (February 29, 2012). Freight train... Amended; Proposed Interpretation; Request for Public Comment'' published at 74 FR 30665-77 (June 26, 2009... laws as amended by the RSIA (the new HS laws). 74 FR 30665 (June 26, 2009). Subsequently FRA...

  8. Determining the dispersion characteristics of rivers from the frequency response of the system

    NASA Astrophysics Data System (ADS)

    Lambertz, Peter; Palancar, MaríA. C.; Aragón, José M.; Gil, Roberto

    2006-09-01

    A new method of determining the parameters of an aggregated dead zone model (ADZ) to predict longitudinal dispersion in rivers is presented. The method is based on the frequency response analysis (FRA) of observed field tests, which consist of tracer injections (input) and measurement of tracer in downstream sampling points (output) located downstream from the injection point. The ADZ is a combination of plug and completely mixed flow compartments. The ADZ parameters (number of compartments, mean residence time, and delay time) are evaluated by means of Bode plots that give the system order (number of compartments), gain, time constant (mean residence time of each compartment) and delay time. The FRA-ADZ method was checked with tracer data runs in two Spanish rivers, the Tagus and the Ebro rivers. The experimental tracer concentration versus time distributions were compared with the ADZ predicted curves, which were calculated using parameters obtained from the FRA method, and with curves predicted by several classical models. The residence time of several reaches within the two studied rivers was predicted by the FRA-ADZ method with a relative error lower than 10%. The method is generally applicable to ideal and nonideal inputs and is particularly well suited to arbitrary-shaped initial source concentration distributions.

  9. 75 FR 2466 - State Highway-Rail Grade Crossing Action Plans

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-15

    ...) published on November 13, 2009 (74 FR 58589), FRA proposed a rule to require the ten States with the most... Statement in the Federal Register published on April 11, 2000 (65 FR 19477-78) or you may visit http://www... Ground Floor, Room W12-140, 1200 New Jersey Avenue, SE., Washington, DC 20590; Hand Delivery:...

  10. 75 FR 34802 - Notice and Request for Comments

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-18

    ... collection of information was published on April 8, 2010 (75 FR 18012). DATES: Comments must be submitted on... this ICR that the agency was seeking OMB approval. 75 FR 18012. FRA received no comments in response to....S.C. 3507 (b)-(c); 5 CFR 1320.12(d); see also 60 FR 44978, 44983, Aug. 29, 1995. OMB believes...

  11. 78 FR 48766 - Petition for Waiver of Compliance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-09

    ...June 24, 2013, Canadian Pacific Railway (CP) has petitioned the Federal Railroad Administration...Number FRA-2003-15010. In its petition, CP requests an extension of its existing waiver...of a single dispatching desk, located in CP's Network Management Center in...

  12. 77 FR 14976 - Approval and Promulgation of Implementation Plans; Tennessee; 110(a)(1) and (2) Infrastructure...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-14

    ... NSR Update) recognizing nitrogen oxide (NOx) as an ozone precursor, among other elements. See 70 FR...(a)(2)(C) and (J) for the 1997 8-hour ozone NAAQS by March 1, 2008. See 73 FR 16205. Specifically... May 28, 2009, SIP revision. See 77 FR 6016. The May 28, 2009, submission was one of two required...

  13. 78 FR 57450 - State Rail Plan Guidance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-18

    ...those used in their other planning and programming documents. Response: FRA has revised...ridership for any but the top ten city pairs, proposing that States simply report...limiting ridership flows to the top city pairs will not provide useful information...

  14. 77 FR 40144 - Adoption of the Environmental Impact Statement (EIS) and Participation in the Section 106...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-06

    ... Access project will open a second Manhattan gateway, greatly expanding its LIRR service by connecting... for commuters who work on Manhattan's East Side. The East Side Access project includes construction of..., 64 FR 28545, May 26, 1999. First, FRA's review concluded that the action encompassed by the MTA...

  15. 76 FR 11992 - Systems for Telephonic Notification of Unsafe Conditions at Highway-Rail and Pathway Grade Crossings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-04

    ...FRA is proposing amendments to its primary regulations on grade crossing safety. The major amendments proposed would require a railroad that dispatches a train through a public or private highway- rail or pathway grade crossing to establish and maintain a system that allows a member of the public to call the railroad and report an emergency or other unsafe condition at the crossing. Upon......

  16. 77 FR 64077 - National Highway-Rail Crossing Inventory Reporting Requirements

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-18

    ...FRA is proposing to require railroads to submit information to the U.S. DOT National Highway-Rail Crossing Inventory about highway- rail crossings and pathway crossings over which they operate. These amendments, which are required by the Rail Safety Improvement Act of 2008 (RSIA), would require railroads to submit information about previously unreported and new public and private highway-rail......

  17. 77 FR 4271 - Special Permit Marking Removal

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-27

    ... first shopping event, whichever occurred first. This document relieves tank car owners from that... that had an established safety record. 75 FR 27205. The final rule amended the HMR to allow, upon the... Register notice providing such approval for certain tank cars. 76 FR 4250. In that notice, FRA stated...

  18. 75 FR 4703 - Track Safety Standards; Continuous Welded Rail (CWR)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-29

    ... (74 FR 42988). FRA published a correcting amendment on October 21, 2009, which added compliance dates... policies and procedures (44 FR 11034, Feb. 26, 1979). The original final rule was determined to be non... principles and criteria contained in Executive Order 13132, ``Federalism'' (64 FR 43255, Aug. 10, 1999)....

  19. 75 FR 76070 - Railroad Safety Advisory Committee (RSAC); Working Group Activity Update

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-07

    ... announcement of working group activities and status reports of August 20, 2010 (75 FR 51525). The 42nd full... March 6, 2007 (72 FR 9904). Comments received were discussed by the Working Group for clarification, and FRA published a final rule on October 19, 2007 (72 FR 59216). The Working Group met on January...

  20. 77 FR 50760 - Notice and request for comments

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-22

    ... disasters that are located in counties that were identified in a Disaster Declaration for Public Assistance... agency was seeking OMB approval. 77 FR 37092. FRA received no comments after issuing this 60- day notice... 1320.12(d); see also 60 FR 44978, 44983, Aug. 29, 1995. OMB believes that the 30 day notice informs...