21 CFR 173.342 - Chlorofluorocarbon 113 and perfluorohexane.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 3 2011-04-01 2011-04-01 false Chlorofluorocarbon 113 and perfluorohexane. 173... perfluorohexane. A mixture of 99 percent chlorofluorocarbon 113 (1,1,2-trichloro-1,2,2-trifluoroethane) (CAS Reg. No. 76-13-1, also known as fluorocarbon 113, CFC 113 and FC 113) and 1 percent perfluorohexane (CAS...

40 CFR 52.1681 - Control strategy: Lead.

Code of Federal Regulations, 2010 CFR

2010-07-01

...) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) New York § 52.1681 Control strategy: Lead. As part of the attainment demonstration for lead, the State of New York has committed to rate all sources...

44 CFR 12.2 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Definitions. 12.2 Section 12.2 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY GENERAL ADVISORY COMMITTEES § 12.2 Definitions. As used in this part— Act means the Federal...

47 CFR 12.2 - Backup power.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 1 2010-10-01 2010-10-01 false Backup power. 12.2 Section 12.2 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL REDUNDANCY OF COMMUNICATIONS SYSTEMS § 12.2 Backup power..., must have an emergency backup power source (e.g., batteries, generators, fuel cells) for all assets...

40 CFR 113.2 - Applicability.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 23 2012-07-01 2012-07-01 false Applicability. 113.2 Section 113.2 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS LIABILITY LIMITS FOR SMALL ONSHORE STORAGE FACILITIES Oil Storage Facilities § 113.2 Applicability. This subpart applies to...

40 CFR 113.2 - Applicability.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 22 2014-07-01 2013-07-01 true Applicability. 113.2 Section 113.2 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS LIABILITY LIMITS FOR SMALL ONSHORE STORAGE FACILITIES Oil Storage Facilities § 113.2 Applicability. This subpart applies to...

40 CFR 721.3248 - Ethane, 1,2,2- trichlorodifluoro-.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Ethane, 1,2,2- trichlorodifluoro-. 721... Substances § 721.3248 Ethane, 1,2,2- trichlorodifluoro-. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as ethane, 1,2,2-trichlorodifluoro- (CAS No...

Self-limited growth of the CaF nanowire on the Si(5 5 12)-2 × 1 template

NASA Astrophysics Data System (ADS)

Kim, Hidong; Duvjir, Ganbat; Dugerjav, Otgonbayar; Li, Huiting; Motlak, Moaaed; Arvisbaatar, Amarmunkh; Seo, Jae M.

2012-10-01

The atomic structure and interfacial bonding of the ordered-and-isolated CaF nanowires on Si(5 5 12)-2 × 1 have been disclosed by scanning tunneling microscopy and synchrotron photoemission spectroscopy. Initially, CaF molecules dissociated from thermally deposited CaF2 molecules are adsorbed preferentially on the chain structures of Si(5 5 12)-2 × 1 held at 500 °C. With increasing CaF2 deposition amount, one-dimensional (1D) CaF nanowires composed of (113) and (111) facets are formed. The line density of these CaF nanowires increases as a function of deposition amount. Finally, at a submonolayer coverage, the surface is saturated with these 1D nanowires except for the (225) subunit, while the original period of Si(5 5 12)-2 × 1, 5.35 nm, is preserved. It has been deduced by the present studies that, owing to these preferential adsorption of CaF and facet-dependent growth of a CaF layer within a unit periodic length of Si(5 5 12)-2 × 1, such a self-limited growth of the CaF nanowire with a high aspect ratio becomes possible.

25 CFR 122.2 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false Definitions. 122.2 Section 122.2 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES MANAGEMENT OF OSAGE JUDGMENT FUNDS FOR EDUCATION... Tribal Education Committee means the committee selected to administer the provisions of this part as...

Publications - GMC 122 | Alaska Division of Geological & Geophysical

Science.gov Websites

DGGS GMC 122 Publication Details Title: Total organic carbon, rock-eval pyrolysis, vitrinite for more information. Bibliographic Reference Exxon, and Geo-Strat, Inc., 1989, Total organic carbon Information gmc122.pdf (1.4 M) Keywords Kerogen; Pyrolysis; Rock-Eval Pyrolysis; Total Organic Carbon

28 CFR 12.2 - Administration of act.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 28 Judicial Administration 1 2011-07-01 2011-07-01 false Administration of act. 12.2 Section 12.2 Judicial Administration DEPARTMENT OF JUSTICE REGISTRATION OF CERTAIN PERSONS HAVING KNOWLEDGE OF FOREIGN ESPIONAGE, COUNTERESPIONAGE, OR SABOTAGE MATTERS UNDER THE ACT OF AUGUST 1, 1956 § 12.2 Administration of...

28 CFR 12.2 - Administration of act.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 28 Judicial Administration 1 2013-07-01 2013-07-01 false Administration of act. 12.2 Section 12.2 Judicial Administration DEPARTMENT OF JUSTICE REGISTRATION OF CERTAIN PERSONS HAVING KNOWLEDGE OF FOREIGN ESPIONAGE, COUNTERESPIONAGE, OR SABOTAGE MATTERS UNDER THE ACT OF AUGUST 1, 1956 § 12.2 Administration of...

28 CFR 12.2 - Administration of act.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Administration of act. 12.2 Section 12.2 Judicial Administration DEPARTMENT OF JUSTICE REGISTRATION OF CERTAIN PERSONS HAVING KNOWLEDGE OF FOREIGN ESPIONAGE, COUNTERESPIONAGE, OR SABOTAGE MATTERS UNDER THE ACT OF AUGUST 1, 1956 § 12.2 Administration of...

28 CFR 12.2 - Administration of act.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 28 Judicial Administration 1 2014-07-01 2014-07-01 false Administration of act. 12.2 Section 12.2 Judicial Administration DEPARTMENT OF JUSTICE REGISTRATION OF CERTAIN PERSONS HAVING KNOWLEDGE OF FOREIGN ESPIONAGE, COUNTERESPIONAGE, OR SABOTAGE MATTERS UNDER THE ACT OF AUGUST 1, 1956 § 12.2 Administration of...

28 CFR 12.2 - Administration of act.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 28 Judicial Administration 1 2012-07-01 2012-07-01 false Administration of act. 12.2 Section 12.2 Judicial Administration DEPARTMENT OF JUSTICE REGISTRATION OF CERTAIN PERSONS HAVING KNOWLEDGE OF FOREIGN ESPIONAGE, COUNTERESPIONAGE, OR SABOTAGE MATTERS UNDER THE ACT OF AUGUST 1, 1956 § 12.2 Administration of...

37 CFR 2.122 - Matters in evidence.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 37 Patents, Trademarks, and Copyrights 1 2011-07-01 2011-07-01 false Matters in evidence. 2.122 Section 2.122 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE, DEPARTMENT OF COMMERCE RULES OF PRACTICE IN TRADEMARK CASES Procedure in Inter Partes Proceedings § 2.122 Matters in...

37 CFR 2.122 - Matters in evidence.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 37 Patents, Trademarks, and Copyrights 1 2013-07-01 2013-07-01 false Matters in evidence. 2.122 Section 2.122 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE, DEPARTMENT OF COMMERCE RULES OF PRACTICE IN TRADEMARK CASES Procedure in Inter Partes Proceedings § 2.122 Matters in...

37 CFR 2.122 - Matters in evidence.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 37 Patents, Trademarks, and Copyrights 1 2012-07-01 2012-07-01 false Matters in evidence. 2.122 Section 2.122 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE, DEPARTMENT OF COMMERCE RULES OF PRACTICE IN TRADEMARK CASES Procedure in Inter Partes Proceedings § 2.122 Matters in...

34 CFR 12.2 - What definitions apply?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 1 2010-07-01 2010-07-01 false What definitions apply? 12.2 Section 12.2 Education Office of the Secretary, Department of Education DISPOSAL AND UTILIZATION OF SURPLUS FEDERAL REAL PROPERTY FOR EDUCATIONAL PURPOSES General § 12.2 What definitions apply? (a) Definitions in the Act. The...

34 CFR 12.2 - What definitions apply?

Code of Federal Regulations, 2014 CFR

2014-07-01

... 34 Education 1 2014-07-01 2014-07-01 false What definitions apply? 12.2 Section 12.2 Education Office of the Secretary, Department of Education DISPOSAL AND UTILIZATION OF SURPLUS FEDERAL REAL PROPERTY FOR EDUCATIONAL PURPOSES General § 12.2 What definitions apply? (a) Definitions in the Act. The...

Palladium-assisted electrodehalogenation of 1,1,2-trichloro-1,2,2-trifluoroethane on lead cathodes combined with hydrogen diffusion anodes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cabot, P.L.; Centelles, M.; Segarra, L.

1997-11-01

In this work, the efficiency and product formation in the electroreduction of 1,1,2-trichloro-1,2,2-trifluoroethane (CFC 113) to obtain completely dechlorinated products has been studied using constant-current electrolysis at different current densities, gas chromatography, scanning electron microscopy, and energy dispersive x-ray. While chlorotrifluoroethene was the main product obtained from CFC 113 in MeOH-water solutions containing NH{sub 4}Cl, different and suitable conditions which lead to its complete dechlorination are described in this paper. In the presence of small amounts of Pd{sup 2+} in solution, a very thin film of Pd black was electrodeposited on the Pb cathode and the efficiency of the CFCmore » 113 electroreduction was about 98%. The efficiency was much smaller and the product composition very different in the absence of Pd{sup 2+} in solution, even in the presence of Pd black electrodeposited on the cathode. In the presence of Pd{sup 2+}, the main products in the gas were difluoroethene and trifluoroethene. Small amounts of 1,2-dichloro-1,1,2-trifluoroethane, chlorotrifluoroethene, difluoroethane, and fluoroethane were also present in the gas phase. The liquid composition was enriched in the less volatile compounds. A possible reaction pathway involving the removal of halides by successive reactions is discussed. The anode employed in these experiments was a thin Pd foil with electrodeposited Pd black, which permitted hydrogen diffusion and its further oxidation to H{sup +}. Because of this reaction, contamination of the working electrolyte by other oxidation products such as Cl{sub 2} or MeOH derivatives were avoided. This system allows new electrosynthetic processes along with CFC electrodegradation.« less

28 CFR 16.81 - Exemption of United States Attorneys Systems-limited access.

Code of Federal Regulations, 2012 CFR

2012-07-01

... DISCLOSURE OF MATERIAL OR INFORMATION Exemption of Records Systems Under the Privacy Act § 16.81 Exemption of... collection of information for law enforcement purposes it is impossible to determine in advance what... collection of information for law enforcement purposes it is impossible to determine in advance what...

28 CFR 16.81 - Exemption of United States Attorneys Systems-limited access.

Code of Federal Regulations, 2011 CFR

2011-07-01

... DISCLOSURE OF MATERIAL OR INFORMATION Exemption of Records Systems Under the Privacy Act § 16.81 Exemption of... collection of information for law enforcement purposes it is impossible to determine in advance what... collection of information for law enforcement purposes it is impossible to determine in advance what...

28 CFR 16.81 - Exemption of United States Attorneys Systems-limited access.

Code of Federal Regulations, 2014 CFR

2014-07-01

... DISCLOSURE OF MATERIAL OR INFORMATION Exemption of Records Systems Under the Privacy Act § 16.81 Exemption of... collection of information for law enforcement purposes it is impossible to determine in advance what... collection of information for law enforcement purposes it is impossible to determine in advance what...

28 CFR 16.81 - Exemption of United States Attorneys Systems-limited access.

Code of Federal Regulations, 2013 CFR

2013-07-01

... DISCLOSURE OF MATERIAL OR INFORMATION Exemption of Records Systems Under the Privacy Act § 16.81 Exemption of... collection of information for law enforcement purposes it is impossible to determine in advance what... collection of information for law enforcement purposes it is impossible to determine in advance what...

37 CFR 2.122 - Matters in evidence.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 37 Patents, Trademarks, and Copyrights 1 2014-07-01 2014-07-01 false Matters in evidence. 2.122 Section 2.122 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE, DEPARTMENT OF... States Patent and Trademark Office showing both the current status of and current title to the...

9 CFR 113.2 - Testing aids.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Testing aids. 113.2 Section 113.2 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES... Testing aids. To better ensure consistent and reproducible test results when Standard Requirement tests...

9 CFR 113.2 - Testing aids.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Testing aids. 113.2 Section 113.2 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES... Testing aids. To better ensure consistent and reproducible test results when Standard Requirement tests...

9 CFR 113.2 - Testing aids.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Testing aids. 113.2 Section 113.2 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES... Testing aids. To better ensure consistent and reproducible test results when Standard Requirement tests...

9 CFR 113.2 - Testing aids.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Testing aids. 113.2 Section 113.2 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES... Testing aids. To better ensure consistent and reproducible test results when Standard Requirement tests...

9 CFR 113.2 - Testing aids.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Testing aids. 113.2 Section 113.2 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES... Testing aids. To better ensure consistent and reproducible test results when Standard Requirement tests...

Molecular basis for defect in Alix-binding by alternatively spliced isoform of ALG-2 (ALG-2DeltaGF122) and structural roles of F122 in target recognition.

PubMed

Inuzuka, Tatsutoshi; Suzuki, Hironori; Kawasaki, Masato; Shibata, Hideki; Wakatsuki, Soichi; Maki, Masatoshi

2010-08-06

ALG-2 (a gene product of PDCD6) belongs to the penta-EF-hand (PEF) protein family and Ca2+-dependently interacts with various intracellular proteins including mammalian Alix, an adaptor protein in the ESCRT system. Our previous X-ray crystal structural analyses revealed that binding of Ca2+ to EF3 enables the side chain of R125 to move enough to make a primary hydrophobic pocket (Pocket 1) accessible to a short fragment of Alix. The side chain of F122, facing a secondary hydrophobic pocket (Pocket 2), interacts with the Alix peptide. An alternatively spliced shorter isoform, designated ALG-2DeltaGF122, lacks Gly121Phe122 and does not bind Alix, but the structural basis of the incompetence has remained to be elucidated. We solved the X-ray crystal structure of the PEF domain of ALG-2DeltaGF122 in the Ca2+-bound form and compared it with that of ALG-2. Deletion of the two residues shortened alpha-helix 5 (alpha5) and changed the configuration of the R125 side chain so that it partially blocked Pocket 1. A wall created by the main chain of 121-GFG-123 and facing the two pockets was destroyed. Surprisingly, however, substitution of F122 with Ala or Gly, but not with Trp, increased the Alix-binding capacity in binding assays. The F122 substitutions exhibited different effects on binding of ALG-2 to other known interacting proteins, including TSG101 (Tumor susceptibility gene 101) and annexin A11. The X-ray crystal structure of the F122A mutant revealed that removal of the bulky F122 side chain not only created an additional open space in Pocket 2 but also abolished inter-helix interactions with W95 and V98 (present in alpha4) and that alpha5 inclined away from alpha4 to expand Pocket 2, suggesting acquirement of more appropriate positioning of the interacting residues to accept Alix. We found that the inability of the two-residue shorter ALG-2 isoform to bind Alix is not due to the absence of bulky side chain of F122 but due to deformation of a main-chain wall facing

MicroRNA-122 mimic transfection contributes to apoptosis in HepG2 cells.

PubMed

Huang, Hongyan; Zhu, Yueyong; Li, Shaoyang

2015-11-01

There is currently a requirement for effective treatment strategies for human hepatocellular carcinoma (HCC), a leading cause of cancer‑associated mortality. MicroRNA-122 (miR-122), a repressor of the endogenous apoptosis regulator Bcl‑w, is frequently downregulated in HCC. Thus, it is hypothesized that the activation of miR‑122 may induce selective hepatocellular apoptosis via caspase activation in a model of HCC. In the present study, an miR‑122 mimic transfection was performed in HepG2 cells, and used to investigate the role and therapeutic potential of miR‑122 in the regulation of HCC‑derived cell lines. The apoptotic rates of HepG2 cells were significantly increased following miR‑122 mimic transfection. Reverse transcription‑polymerase chain reaction analysis revealed that Bcl‑w mRNA was significantly reduced, while the mRNA levels of caspase‑9 and caspase‑3 were markedly increased. The immunocytochemistry results supported the mRNA trends. Collectively, the present results suggest that endogenous miR‑122 contributes to HepG2 apoptosis and that transfection of mimic miR‑122 normalizes apoptotic levels in a model of HCC.

Hepatitis C Virus Core Protein Promotes miR-122 Destabilization by Inhibiting GLD-2

PubMed Central

Kim, Geon-Woo; Lee, Seung-Hoon; Cho, Hee; Kim, Minwoo; Shin, Eui-Cheol; Oh, Jong-Won

2016-01-01

The liver-specific microRNA miR-122, which has essential roles in liver development and metabolism, is a key proviral factor for hepatitis C virus (HCV). Despite its crucial role in the liver and HCV life cycle, little is known about the molecular mechanism of miR-122 expression regulation by HCV infection. Here, we show that the HCV core protein downregulates the abundance of miR-122 by promoting its destabilization via the inhibition of GLD-2, a non-canonical cytoplasmic poly(A) polymerase. The decrease in miR-122 expression resulted in the dysregulation of the known functions of miR-122, including its proviral activity for HCV. By high-throughput sequencing of small RNAs from human liver biopsies, we found that the 22-nucleotide (nt) prototype miR-122 is modified at its 3′ end by 3′-terminal non-templated and templated nucleotide additions. Remarkably, the proportion of miR-122 isomers bearing a single nucleotide tail of any ribonucleotide decreased in liver specimens from patients with HCV. We found that these single-nucleotide-tailed miR-122 isomers display increased miRNA activity and stability over the 22-nt prototype miR-122 and that the 3′-terminal extension is catalyzed by the unique terminal nucleotidyl transferase activity of GLD-2, which is capable of adding any single ribonucleotide without preference of adenylate to the miR-122 3′ end. The HCV core protein specifically inhibited GLD-2, and its interaction with GLD-2 in the cytoplasm was found to be responsible for miR-122 downregulation. Collectively, our results provide new insights into the regulatory role of the HCV core protein in controlling viral RNA abundance and miR-122 functions through miR-122 stability modulation. PMID:27366906

9 CFR 113.305 - Canine Hepatitis and Canine Adenovirus Type 2 Vaccine.

Code of Federal Regulations, 2013 CFR

2013-01-01

... Type 2 Vaccine. 113.305 Section 113.305 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION... STANDARD REQUIREMENTS Live Virus Vaccines § 113.305 Canine Hepatitis and Canine Adenovirus Type 2 Vaccine. Canine Hepatitis Vaccine and Canine Adenovirus Type 2 Vaccine shall be prepared from virus-bearing cell...

9 CFR 113.305 - Canine Hepatitis and Canine Adenovirus Type 2 Vaccine.

Code of Federal Regulations, 2012 CFR

2012-01-01

... Type 2 Vaccine. 113.305 Section 113.305 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION... STANDARD REQUIREMENTS Live Virus Vaccines § 113.305 Canine Hepatitis and Canine Adenovirus Type 2 Vaccine. Canine Hepatitis Vaccine and Canine Adenovirus Type 2 Vaccine shall be prepared from virus-bearing cell...

9 CFR 113.305 - Canine Hepatitis and Canine Adenovirus Type 2 Vaccine.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Type 2 Vaccine. 113.305 Section 113.305 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION... STANDARD REQUIREMENTS Live Virus Vaccines § 113.305 Canine Hepatitis and Canine Adenovirus Type 2 Vaccine. Canine Hepatitis Vaccine and Canine Adenovirus Type 2 Vaccine shall be prepared from virus-bearing cell...

9 CFR 113.305 - Canine Hepatitis and Canine Adenovirus Type 2 Vaccine.

Code of Federal Regulations, 2014 CFR

2014-01-01

... Type 2 Vaccine. 113.305 Section 113.305 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION... STANDARD REQUIREMENTS Live Virus Vaccines § 113.305 Canine Hepatitis and Canine Adenovirus Type 2 Vaccine. Canine Hepatitis Vaccine and Canine Adenovirus Type 2 Vaccine shall be prepared from virus-bearing cell...

Acting Locally, Thinking Globally: One Geology?

NASA Astrophysics Data System (ADS)

Jackson, Ian

2010-02-01

Geological survey organizations around the world are responsible for geological data for their own countries, but until recently those data had never been made accessible worldwide. This raised the question of whether we really do have a holistic understanding of the geology of our planet—one geology. OneGeology (http://www.onegeology.org) is a global venture created to increase the accessibility of geological map data and make them available on the Web. Geological survey organizations from 113 countries are currently participating in ¬OneGeology, and to date more than 40 of those organizations are serving geological data to a dedicated Web map portal (see Figure 1).

16 CFR 640.2 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-01-01

....C. 1681a(r)(5). (i) Creditor has the same meaning as in 15 U.S.C. 1681a(r)(5). (j) Credit card has the same meaning as in 15 U.S.C. 1681a(r)(2). (k) Credit card issuer has the same meaning as in 15 U.S... action has the same meaning as in 15 U.S.C. 1681a(k)(1)(A). (b) Annual percentage rate has the same...

16 CFR 640.2 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-01-01

....C. 1681a(r)(5). (i) Creditor has the same meaning as in 15 U.S.C. 1681a(r)(5). (j) Credit card has the same meaning as in 15 U.S.C. 1681a(r)(2). (k) Credit card issuer has the same meaning as in 15 U.S... action has the same meaning as in 15 U.S.C. 1681a(k)(1)(A). (b) Annual percentage rate has the same...

16 CFR 640.2 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-01-01

....C. 1681a(r)(5). (i) Creditor has the same meaning as in 15 U.S.C. 1681a(r)(5). (j) Credit card has the same meaning as in 15 U.S.C. 1681a(r)(2). (k) Credit card issuer has the same meaning as in 15 U.S... action has the same meaning as in 15 U.S.C. 1681a(k)(1)(A). (b) Annual percentage rate has the same...

16 CFR 640.2 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-01-01

....C. 1681a(r)(5). (i) Creditor has the same meaning as in 15 U.S.C. 1681a(r)(5). (j) Credit card has the same meaning as in 15 U.S.C. 1681a(r)(2). (k) Credit card issuer has the same meaning as in 15 U.S... action has the same meaning as in 15 U.S.C. 1681a(k)(1)(A). (b) Annual percentage rate has the same...

miR-122 targets NOD2 to decrease intestinal epithelial cell injury in Crohn’s disease

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, Yu; Wang, Chengxiao; Liu, Ying

2013-08-16

Highlights: •NOD2 is a target gene of miR-122. •miR-122 inhibits LPS-induced apoptosis by suppressing NOD2 in HT-29 cells. •miR-122 reduces the expression of pro-inflammatory cytokines (TNF-α and IFN-γ). •miR-122 promotes the release of anti-inflammatory cytokines (IL-4 and IL-10). •NF-κB signaling pathway is involved in inflammatory response induced by LPS. -- Abstract: Crohn’s disease (CD) is one of the two major types of inflammatory bowel disease (IBD) thought to be caused by genetic and environmental factors. Recently, miR-122 was found to be deregulated in association with CD progression. However, the underlying molecular mechanisms remain unclear. In the present study, the genemore » nucleotide-binding oligomerization domain 2 (NOD2/CARD15), which is strongly associated with susceptibility to CD, was identified as a functional target of miR-122. MiR-122 inhibited LPS-induced apoptosis by suppressing NOD2 in HT-29 cells. NOD2 interaction with LPS initiates signal transduction mechanisms resulting in the activation of nuclear factor κB (NF-κB) and the stimulation of downstream pro-inflammatory events. The activation of NF-κB was inhibited in LPS-stimulated HT-29 cells pretreated with miR-122 precursor or NOD2 shRNA. The expression of the pro-inflammatory cytokines TNF-α and IFN-γ was significantly decreased, whereas therelease of the anti-inflammatory cytokines IL-4 and IL-10 was increased in LPS-stimulated HT-29 cells pretreated with miR-122 precursor, NOD2 shRNA or the NF-κB inhibitor QNZ. Taken together, these results indicate that miR-122 and its target gene NOD2 may play an important role in the injury of intestinal epithelial cells induced by LPS.« less

9 CFR 113.202 - Canine Hepatitis and Canine Adenovirus Type 2 Vaccine, Killed Virus.

Code of Federal Regulations, 2014 CFR

2014-01-01

... Type 2 Vaccine, Killed Virus. 113.202 Section 113.202 Animals and Animal Products ANIMAL AND PLANT...; ORGANISMS AND VECTORS STANDARD REQUIREMENTS Killed Virus Vaccines § 113.202 Canine Hepatitis and Canine Adenovirus Type 2 Vaccine, Killed Virus. Canine Hepatitis and Canine Adenovirus Type 2 Vaccine, Killed Virus...

9 CFR 113.202 - Canine Hepatitis and Canine Adenovirus Type 2 Vaccine, Killed Virus.

Code of Federal Regulations, 2013 CFR

2013-01-01

... Type 2 Vaccine, Killed Virus. 113.202 Section 113.202 Animals and Animal Products ANIMAL AND PLANT...; ORGANISMS AND VECTORS STANDARD REQUIREMENTS Killed Virus Vaccines § 113.202 Canine Hepatitis and Canine Adenovirus Type 2 Vaccine, Killed Virus. Canine Hepatitis and Canine Adenovirus Type 2 Vaccine, Killed Virus...

9 CFR 113.202 - Canine Hepatitis and Canine Adenovirus Type 2 Vaccine, Killed Virus.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Type 2 Vaccine, Killed Virus. 113.202 Section 113.202 Animals and Animal Products ANIMAL AND PLANT...; ORGANISMS AND VECTORS STANDARD REQUIREMENTS Killed Virus Vaccines § 113.202 Canine Hepatitis and Canine Adenovirus Type 2 Vaccine, Killed Virus. Canine Hepatitis and Canine Adenovirus Type 2 Vaccine, Killed Virus...

9 CFR 113.202 - Canine Hepatitis and Canine Adenovirus Type 2 Vaccine, Killed Virus.

Code of Federal Regulations, 2012 CFR

2012-01-01

... Type 2 Vaccine, Killed Virus. 113.202 Section 113.202 Animals and Animal Products ANIMAL AND PLANT...; ORGANISMS AND VECTORS STANDARD REQUIREMENTS Killed Virus Vaccines § 113.202 Canine Hepatitis and Canine Adenovirus Type 2 Vaccine, Killed Virus. Canine Hepatitis and Canine Adenovirus Type 2 Vaccine, Killed Virus...

34 CFR 300.122 - Evaluation.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false Evaluation. 300.122 Section 300.122 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND... DISABILITIES State Eligibility Additional Eligibility Requirements § 300.122 Evaluation. Children with...

12.2-GHz methanol maser MMB follow-up catalogue - IV. Longitude range 20°-60°

NASA Astrophysics Data System (ADS)

Breen, S. L.; Ellingsen, S. P.; Caswell, J. L.; Green, J. A.; Voronkov, M. A.; Avison, A.; Fuller, G. A.; Quinn, L. J.

2016-07-01

This is the fourth and final instalment of a series of catalogues presenting 12.2-GHz methanol maser observations made towards each of the 6.7-GHz methanol masers detected in the Methanol Multibeam (MMB) survey. This final portion of the survey covers the 20°-60° longitude range, increasing the 12.2-GHz follow-up range to the full MMB coverage of 186° ≥ l ≤ 60° and |b| ≤ 2°. Towards a total of 260 6.7-GHz MMB methanol masers (we were unable to observe five of the MMB sources in this longitude range) we detect 116 12.2-GHz masers counterparts, 64 of which were discovered in this survey. Including data from the literature, we find that there are 12.2-GHz methanol masers towards 47.1 per cent of the 6.7-GHz methanol masers in this portion of the Galaxy. Across the entire MMB survey range, we find a detection rate of 45.3 per cent. We find that the detection rate of 12.2-GHz methanol masers as a function of Galactic longitude is not uniform and there is an excess of masers with broad velocity ranges at longitudes near 30° and 330°. Comparing the occurrence of 12.2-GHz methanol masers with MMB-targeted CO observations has shown that those outflows associated with a 12.2-GHz source have a larger average dynamical time-scale than those associated with only 6.7-GHz methanol masers, supporting the notion that the 12.2-GHz masers are associated with a later phase of high-mass star formation.

9 CFR 113.113 - Autogenous biologics.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Autogenous biologics. 113.113 Section 113.113 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS STANDARD REQUIREMENTS...

The A12.2 Subunit Is an Intrinsic Destabilizer of the RNA Polymerase I Elongation Complex.

PubMed

Appling, Francis D; Scull, Catherine E; Lucius, Aaron L; Schneider, David A

2018-06-05

Despite sharing a highly conserved core architecture with their prokaryotic counterparts, eukaryotic multisubunit RNA polymerases (Pols) have undergone structural divergence and biological specialization. Interesting examples of structural divergence are the A12.2 and C11 subunits of Pols I and III, respectively. Whereas all known cellular Pols possess cognate protein factors that stimulate cleavage of the nascent RNA, Pols I and III have incorporated their cleavage factors as bona fide subunits. Although it is not yet clear why these polymerases have incorporated their cleavage factors as subunits, a picture is emerging that identifies roles for these subunits beyond providing nucleolytic activity. Specifically, it appears that both A12.2 and C11 are required for efficient termination of transcription by Pols I and III. Given that termination involves destabilization of the elongation complex (EC), we tested whether A12.2 influences stability of the Pol I EC. Using, to our knowledge, a novel assay to measure EC dissociation kinetics, we have determined that A12.2 is an intrinsic destabilizer of the Pol I EC. In addition, the salt concentration dependence of Pol I EC dissociation kinetics suggests that A12.2 alters electrostatic interactions within the EC. Importantly, these data present a mechanistic basis for the requirement of A12.2 in Pol I termination. Combined with recent work demonstrating the direct involvement of A12.2 in Pol I nucleotide incorporation, this study further supports the concept that A12.2 cannot be viewed solely as a cleavage factor. Copyright © 2018 Biophysical Society. Published by Elsevier Inc. All rights reserved.

Observation of the Hadronic transitions chi(b1,2)(2P)-->omegaUpsilon(1S).

PubMed

Cronin-Hennessy, D; Park, C S; Park, W; Thayer, J B; Thorndike, E H; Coan, T E; Gao, Y S; Liu, F; Stroynowski, R; Artuso, M; Boulahouache, C; Blusk, S; Dambasuren, E; Dorjkhaidav, O; Mountain, R; Muramatsu, H; Nandakumar, R; Skwarnicki, T; Stone, S; Wang, J C; Mahmood, A H; Csorna, S E; Bonvicini, G; Cinabro, D; Dubrovin, M; Bornheim, A; Lipeles, E; Pappas, S P; Shapiro, A; Sun, W M; Weinstein, A J; Briere, R A; Chen, G P; Ferguson, T; Tatishvili, G; Vogel, H; Watkins, M E; Adam, N E; Alexander, J P; Berkelman, K; Boisvert, V; Cassel, D G; Duboscq, J E; Ecklund, K M; Ehrlich, R; Galik, R S; Gibbons, L; Gittelman, B; Gray, S W; Hartill, D L; Heltsley, B K; Hsu, L; Jones, C D; Kandaswamy, J; Kreinick, D L; Kuznetsov, V E; Magerkurth, A; Mahlke-Krüger, H; Meyer, T O; Mistry, N B; Patterson, J R; Pedlar, T K; Peterson, D; Pivarski, J; Richichi, S J; Riley, D; Sadoff, A J; Schwarthoff, H; Shepherd, M R; Thayer, J G; Urner, D; Wilksen, T; Warburton, A; Weinberger, M; Athar, S B; Avery, P; Breva-Newell, L; Potlia, V; Stoeck, H; Yelton, J; Eisenstein, B I; Gollin, G D; Karliner, I; Lowrey, N; Plager, C; Sedlack, C; Selen, M; Thaler, J J; Williams, J; Edwards, K W; Besson, D; Gao, K Y; Gong, D T; Kubota, Y; Li, S Z; Poling, R; Scott, A W; Smith, A; Stepaniak, C J; Urheim, J; Metreveli, Z; Seth, K K; Tomaradze, A; Zweber, P; Ernst, J; Arms, K; Eckhart, E; Gan, K K; Gwon, C; Severini, H; Skubic, P; Dytman, S A; Mueller, J A; Nam, S; Savinov, V; Huang, G S; Miller, D H; Pavlunin, V; Sanghi, B; Shibata, E I; Shipsey, I P J; Danko, I

2004-06-04

The CLEO Collaboration has made the first observations of hadronic transitions among bottomonium (bbmacr;) states other than the dipion transitions among Upsilon(nS) states. In our study of Upsilon(3S) decays, we find a significant signal for Upsilon(3S)-->gammaomegaUpsilon(1S) that is consistent with radiative decays Upsilon(3S)-->gammachi(b1,2)(2P), followed by chi(b1,2)(2P)-->omegaUpsilon(1S). The branching ratios we obtain are B[chi(b1)(2P)-->omegaUpsilon(1S)]=(1.63(+0.35+0.16)(-0.31-0.15))% and B[chi(b2)(2P)-->omegaUpsilon(1S)]=(1.10(+0.32+0.11)(-0.28-0.10))%, in which the first error is statistical and the second is systematic.

High pressure low temperature studies on 1-2-2 iron-based superconductors using designer diamond cells

DOE Office of Scientific and Technical Information (OSTI.GOV)

Uhoya, Walter O.; Tsoi, Georgiy M.; Vohra, Yogesh K.

In this study, high pressure low temperature electrical resistance measurements were carried out on a series of 122 iron-based superconductors using a designer diamond anvil cell. These studies were complemented by image plate x-ray diffraction measurements under high pressures and low temperatures at beamline 16-BM-D, HPCAT, Advanced Photon Source. A common feature of the 1-2-2 iron-based materials is the observation of anomalous compressibility effects under pressure and a Tetragonal (T) to Collapsed Tetragonal (CT) phase transition under high pressures. Specific studies on antiferromagnetic spin-density-wave Ba 0.5Sr 0.5Fe 2As 2 and Ba(Fe 0.9Ru 0.1) 2As 2 samples are presented to 10more » K and 41 GPa. The collapsed tetragonal phase was observed at a pressure of 14 GPa in Ba 0.5Sr 0.5Fe 2As 2 at ambient temperature. The highest superconducting transition temperature in Ba 0.5Sr 0.5Fe 2As 2 was observed to be at 32 K at a pressure of 4.7 GPa. The superconductivity was observed to be suppressed on transformation to the CT phase in 122 materials.« less

10 CFR 110.122 - Classification assistance.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 2 2013-01-01 2013-01-01 false Classification assistance. 110.122 Section 110.122 Energy... Procedures for Classified Information in Hearings § 110.122 Classification assistance. On the request of any... security classification of information and the protective requirements to be observed. ...

10 CFR 110.122 - Classification assistance.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 2 2012-01-01 2012-01-01 false Classification assistance. 110.122 Section 110.122 Energy... Procedures for Classified Information in Hearings § 110.122 Classification assistance. On the request of any... security classification of information and the protective requirements to be observed. ...

10 CFR 110.122 - Classification assistance.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 2 2014-01-01 2014-01-01 false Classification assistance. 110.122 Section 110.122 Energy... Procedures for Classified Information in Hearings § 110.122 Classification assistance. On the request of any... security classification of information and the protective requirements to be observed. ...

10 CFR 110.122 - Classification assistance.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 2 2011-01-01 2011-01-01 false Classification assistance. 110.122 Section 110.122 Energy... Procedures for Classified Information in Hearings § 110.122 Classification assistance. On the request of any... security classification of information and the protective requirements to be observed. ...

10 CFR 110.122 - Classification assistance.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 2 2010-01-01 2010-01-01 false Classification assistance. 110.122 Section 110.122 Energy... Procedures for Classified Information in Hearings § 110.122 Classification assistance. On the request of any... security classification of information and the protective requirements to be observed. ...

18 CFR 401.122 - Supplementary details.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 18 Conservation of Power and Water Resources 2 2011-04-01 2011-04-01 false Supplementary details. 401.122 Section 401.122 Conservation of Power and Water Resources DELAWARE RIVER BASIN COMMISSION ADMINISTRATIVE MANUAL RULES OF PRACTICE AND PROCEDURE General Provisions § 401.122 Supplementary details. Forms...

Interferometric measurement of the 1S/sub 1/2/-2S/sub 1/2/ transition frequency in atomic hydrogen

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barr, J.R.M.; Girkin, J.M.; Tolchard, J.M.

The 1S/sub 1/2/-2S/sub 1/2/ transition frequency in atomic hydrogen has been interferometrically measured by comparison with a reference line in /sup 130/Te/sub 2/ by Doppler-free two-photon laser spectroscopy. The measured 1S/sub 1/2/-2S/sub 1/2/ transition frequency of 2 466 061 397(25) MHz is in good agreement with the theoretical predictions of Erickson modified to take account of recent measurements of the Rydberg constant. This measurement can be used to deduce a value for the ground-state Lamb shift and gives the result of 8182(25) MHz which compares with a value of 8173.248(81) MHz predicted by Erickson.

Circulating MicroRNA-122 Is Associated With the Risk of New-Onset Metabolic Syndrome and Type 2 Diabetes

PubMed Central

Skroblin, Philipp; Moschen, Alexander R.; Yin, Xiaoke; Kaudewitz, Dorothee; Zampetaki, Anna; Barwari, Temo; Whitehead, Meredith; Ramírez, Cristina M.; Goedeke, Leigh; Rotllan, Noemi; Bonora, Enzo; Hughes, Alun D.; Santer, Peter; Fernández-Hernando, Carlos; Tilg, Herbert; Willeit, Johann; Kiechl, Stefan

2017-01-01

MicroRNA-122 (miR-122) is abundant in the liver and involved in lipid homeostasis, but its relevance to the long-term risk of developing metabolic disorders is unknown. We therefore measured circulating miR-122 in the prospective population-based Bruneck Study (n = 810; survey year 1995). Circulating miR-122 was associated with prevalent insulin resistance, obesity, metabolic syndrome, type 2 diabetes, and an adverse lipid profile. Among 92 plasma proteins and 135 lipid subspecies quantified with mass spectrometry, it correlated inversely with zinc-α-2-glycoprotein and positively with afamin, complement factor H, VLDL-associated apolipoproteins, and lipid subspecies containing monounsaturated and saturated fatty acids. Proteomics analysis of livers from antagomiR-122–treated mice revealed novel regulators of hepatic lipid metabolism that are responsive to miR-122 inhibition. In the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT, n = 155), 12-month atorvastatin reduced circulating miR-122. A similar response to atorvastatin was observed in mice and cultured murine hepatocytes. Over up to 15 years of follow-up in the Bruneck Study, multivariable adjusted risk ratios per one-SD higher log miR-122 were 1.60 (95% CI 1.30–1.96; P < 0.001) for metabolic syndrome and 1.37 (1.03–1.82; P = 0.021) for type 2 diabetes. In conclusion, circulating miR-122 is strongly associated with the risk of developing metabolic syndrome and type 2 diabetes in the general population. PMID:27899485

25 CFR 12.2 - What is the role of the Bureau of Indian Affairs Director of Law Enforcement Services?

Code of Federal Regulations, 2014 CFR

2014-04-01

... of Law Enforcement Services? 12.2 Section 12.2 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAW AND ORDER INDIAN COUNTRY LAW ENFORCEMENT Responsibilities § 12.2 What is the role of the Bureau of Indian Affairs Director of Law Enforcement Services? The Director of the Office of Law...

25 CFR 12.2 - What is the role of the Bureau of Indian Affairs Director of Law Enforcement Services?

Code of Federal Regulations, 2012 CFR

2012-04-01

... of Law Enforcement Services? 12.2 Section 12.2 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAW AND ORDER INDIAN COUNTRY LAW ENFORCEMENT Responsibilities § 12.2 What is the role of the Bureau of Indian Affairs Director of Law Enforcement Services? The Director of the Office of Law...

25 CFR 12.2 - What is the role of the Bureau of Indian Affairs Director of Law Enforcement Services?

Code of Federal Regulations, 2011 CFR

2011-04-01

... of Law Enforcement Services? 12.2 Section 12.2 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAW AND ORDER INDIAN COUNTRY LAW ENFORCEMENT Responsibilities § 12.2 What is the role of the Bureau of Indian Affairs Director of Law Enforcement Services? The Director of the Office of Law...

25 CFR 12.2 - What is the role of the Bureau of Indian Affairs Director of Law Enforcement Services?

Code of Federal Regulations, 2013 CFR

2013-04-01

... of Law Enforcement Services? 12.2 Section 12.2 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAW AND ORDER INDIAN COUNTRY LAW ENFORCEMENT Responsibilities § 12.2 What is the role of the Bureau of Indian Affairs Director of Law Enforcement Services? The Director of the Office of Law...

34 CFR 300.122 - Evaluation.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 34 Education 2 2011-07-01 2010-07-01 true Evaluation. 300.122 Section 300.122 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION ASSISTANCE TO STATES FOR THE EDUCATION OF CHILDREN WITH...

40 CFR 51.113 - [Reserved

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 2 2010-07-01 2010-07-01 false [Reserved] 51.113 Section 51.113 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS REQUIREMENTS FOR PREPARATION, ADOPTION, AND SUBMITTAL OF IMPLEMENTATION PLANS Control Strategy § 51.113 [Reserved] ...

The non-competitive acetylcholinesterase inhibitor APS12-2 is a potent antagonist of skeletal muscle nicotinic acetylcholine receptors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Grandič, Marjana; Aráoz, Romulo; Molgó, Jordi

APS12-2, a non-competitive acetylcholinesterase inhibitor, is one of the synthetic analogs of polymeric alkylpyridinium salts (poly-APS) isolated from the marine sponge Reniera sarai. In the present work the effects of APS12-2 were studied on isolated mouse phrenic nerve–hemidiaphragm muscle preparations, using twitch tension measurements and electrophysiological recordings. APS12-2 in a concentration-dependent manner blocked nerve-evoked isometric muscle contraction (IC{sub 50} = 0.74 μM), without affecting directly-elicited twitch tension up to 2.72 μM. The compound (0.007–3.40 μM) decreased the amplitude of miniature endplate potentials until a complete block by concentrations higher than 0.68 μM, without affecting their frequency. Full size endplate potentials,more » recorded after blocking voltage-gated muscle sodium channels, were inhibited by APS12-2 in a concentration-dependent manner (IC{sub 50} = 0.36 μM) without significant change in the resting membrane potential of the muscle fibers up to 3.40 μM. The compound also blocked acetylcholine-evoked inward currents in Xenopus oocytes in which Torpedo (α1{sub 2}β1γδ) muscle-type nicotinic acetylcholine receptors (nAChRs) have been incorporated (IC{sub 50} = 0.0005 μM), indicating a higher affinity of the compound for Torpedo (α1{sub 2}β1γδ) than for the mouse (α1{sub 2}β1γε) nAChR. Our data show for the first time that APS12-2 blocks neuromuscular transmission by a non-depolarizing mechanism through an action on postsynaptic nAChRs of the skeletal neuromuscular junction. -- Highlights: ► APS12-2 produces concentration-dependent inhibition of nerve-evoked muscle contraction in vitro. ► APS12-2 blocks MEPPs and EPPs at the neuromuscular junction. APS12-2 blocks ACh-activated current in Xenopus oocytes incorporated with Torpedo nAChRs.« less

28 CFR 551.113 - Counseling.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Counseling. 551.113 Section 551.113... Pretrial Inmates § 551.113 Counseling. (a) When consistent with institution security and good order, pretrial inmates may be allowed the opportunity to receive counseling services with convicted inmates. (b...

28 CFR 551.113 - Counseling.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Counseling. 551.113 Section 551.113... Pretrial Inmates § 551.113 Counseling. (a) When consistent with institution security and good order, pretrial inmates may be allowed the opportunity to receive counseling services with convicted inmates. (b...

28 CFR 551.113 - Counseling.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Counseling. 551.113 Section 551.113... Pretrial Inmates § 551.113 Counseling. (a) When consistent with institution security and good order, pretrial inmates may be allowed the opportunity to receive counseling services with convicted inmates. (b...

28 CFR 551.113 - Counseling.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Counseling. 551.113 Section 551.113... Pretrial Inmates § 551.113 Counseling. (a) When consistent with institution security and good order, pretrial inmates may be allowed the opportunity to receive counseling services with convicted inmates. (b...

28 CFR 551.113 - Counseling.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 28 Judicial Administration 2 2011-07-01 2011-07-01 false Counseling. 551.113 Section 551.113... Pretrial Inmates § 551.113 Counseling. (a) When consistent with institution security and good order, pretrial inmates may be allowed the opportunity to receive counseling services with convicted inmates. (b...

21 CFR 113.60 - Containers.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Containers. 113.60 Section 113.60 Food and Drugs... CONSUMPTION THERMALLY PROCESSED LOW-ACID FOODS PACKAGED IN HERMETICALLY SEALED CONTAINERS Control of Components, Food Product Containers, Closures, and In-Process Materials § 113.60 Containers. (a) Closures...

21 CFR 113.60 - Containers.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 2 2012-04-01 2012-04-01 false Containers. 113.60 Section 113.60 Food and Drugs... CONSUMPTION THERMALLY PROCESSED LOW-ACID FOODS PACKAGED IN HERMETICALLY SEALED CONTAINERS Control of Components, Food Product Containers, Closures, and In-Process Materials § 113.60 Containers. (a) Closures...

21 CFR 113.60 - Containers.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 2 2013-04-01 2013-04-01 false Containers. 113.60 Section 113.60 Food and Drugs... CONSUMPTION THERMALLY PROCESSED LOW-ACID FOODS PACKAGED IN HERMETICALLY SEALED CONTAINERS Control of Components, Food Product Containers, Closures, and In-Process Materials § 113.60 Containers. (a) Closures...

21 CFR 113.60 - Containers.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 2 2014-04-01 2014-04-01 false Containers. 113.60 Section 113.60 Food and Drugs... CONSUMPTION THERMALLY PROCESSED LOW-ACID FOODS PACKAGED IN HERMETICALLY SEALED CONTAINERS Control of Components, Food Product Containers, Closures, and In-Process Materials § 113.60 Containers. (a) Closures...

42 CFR 411.122 - Hearing officer's decision.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 2 2010-10-01 2010-10-01 false Hearing officer's decision. 411.122 Section 411.122... Covered Under Group Health Plans: General Provisions § 411.122 Hearing officer's decision. (a) Timing. (1... decision. The hearing officer's decision is the final Departmental decision and is binding upon all parties...

21 CFR 113.60 - Containers.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Containers. 113.60 Section 113.60 Food and Drugs... CONSUMPTION THERMALLY PROCESSED LOW-ACID FOODS PACKAGED IN HERMETICALLY SEALED CONTAINERS Control of Components, Food Product Containers, Closures, and In-Process Materials § 113.60 Containers. Link to an...

21 CFR 163.113 - Cocoa.

Code of Federal Regulations, 2010 CFR

2010-04-01

... CONSUMPTION CACAO PRODUCTS Requirements for Specific Standardized Cacao Products § 163.113 Cocoa. (a) Description. Cocoa is the food that conforms to the definition and standard of identity, and is subject to the... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Cocoa. 163.113 Section 163.113 Food and Drugs FOOD...

Xenosensor CAR mediates down-regulation of miR-122 and up-regulation of miR-122 targets in the liver

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kazantseva, Yuliya A.; Yarushkin, Andrei A.; Mostovich, Lyudmila A.

MiR-122 is a major hepatic microRNA, accounting for more than 70% of the total liver miRNA population. It has been shown that miR-122 is associated with liver diseases, including hepatocellular carcinoma. Mir-122 is an intergenic miRNA with its own promoter. Pri-miR-122 expression is regulated by liver-enriched transcription factors, mainly by HNF4α, which mediates the expression via the interaction with a specific DR1 site. It has been shown that phenobarbital-mediated activation of constitutive androstane receptor (CAR), xenobiotic nuclear receptor, is associated with a decrease in miR-122 in the liver. In the present study, we investigated HNF4α–CAR cross-talk in the regulation ofmore » miR-122 levels and promitogenic signalling in mouse livers. The level of miR-122 was significantly repressed by treatment with 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP), which is an agonist of mouse CAR. ChIP assays demonstrated that TCPOBOP-activated CAR inhibited HNF4α transactivation by competing with HNF4α for binding to the DR1 site in the pri-miR-122 promoter. Such transcription factor replacement was strongly correlated with miR-122 down-regulation. Additionally, the decrease in miR-122 levels produced by CAR activation is accompanied by an increase in mRNA and cellular protein levels of E2f1 and its accumulation on the target cMyc gene promoter. The increase in accumulation of E2f1 on the target cMyc gene promoter is accompanied by an increase in cMyc levels and transcriptional activity. Thus, our results provide evidence to support the conclusion that CAR activation decreases miR-122 levels through suppression of HNF4α transcriptional activity and indirectly regulates the promitogenic protein cMyc. HNF4α–CAR cross-talk may provide new opportunities for understanding liver diseases and developing more effective therapeutic approaches to better drug treatments. - Highlights: • CAR activation decreased the level of miR-122 in mouse livers. • CAR

Expression of microRNA-122 contributes to apoptosis in H9C2 myocytes

PubMed Central

Huang, Xiaoyan; Huang, Fang; Yang, Deye; Dong, Fengquan; Shi, Xiangxiang; Wang, Hongyu; Zhou, Xi; Wang, Suyun; Dai, Shengchuan

2012-01-01

The microRNAs (miRNAs) can post-transcriptionally regulate gene expression and heart development. The Pax-8 gene knockout mice have apparent heart abnormalities. This study investigated the role of miRNAs in regulation of cardiac apoptosis and development in the knockout mice. MicroRNA microarrays demonstrated differential expression of microRNAs between Pax-8−/− and Pax-8+/− mice, confirmed by real-time PCR. The miR-122 was up-regulated by 1.92 folds in Pax-8−/− mice. There were ventricular septum defects in Pax-8−/− mice, and increased numbers of apoptotic cells in the left ventricular wall and interventricular septum in Pax-8−/− mice. In H9C2 myocytes, treatment with miR-122 mimics or miR-122 inhibitor affects the expression of CCK-8 and activity of Caspase-3. The miR-122 is up-regulated in the myocytes of Pax-8−/− mice and may participate in the apoptotic gene expression and pathogenesis of heart development defect. PMID:22453009

40 CFR 122.29 - New sources and new dischargers.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 21 2010-07-01 2010-07-01 false New sources and new dischargers. 122... Application and Special NPDES Program Requirements § 122.29 New sources and new dischargers. (a) Definitions. (1) New source and new discharger are defined in § 122.2. [See Note 2.] (2) Source means any building...

Evaluation of exposures to fluorocarbon 113 in a horizontal and a vertical laminar airflow clean room.

PubMed

Bloom, T F; Egeland, G M

1999-01-01

Exposures to 1,1,2-trichloro-1,2,2-trifluoroethane or fluorocarbon (FC) 113 were evaluated in a horizontal laminar airflow (HLAF) clean room and a vertical laminar airflow (VLAF) clean room. A full period consecutive samples measurement strategy was employed. Data were used to calculate 8-hour time-weighted averages (8-TWA) for major work groups and to characterize exposures associated with specific cleaning tasks. The MIRAN 1B infrared analyzer was used to estimate peak concentrations. In the HLAF clean room, 8-TWAs ranged from 193 to 439 ppm; in the VLAF clean room, 8-TWAs ranged from 110 to 935 ppm. These levels were below the current Occupational Safety and Health Administration permissible exposure limit and the National Institute for Occupational Safety and Health (NIOSH) recommended exposure limit for FC 113 of 1000 ppm. Short-term sample concentrations ranged from 104 ppm (inspection) to 1080 ppm (assembly) in the HLAF clean room and 51 ppm (packaging)-3380 ppm (flushing) in the VLAF clean room. In the VLAF clean room, several short-term concentrations measured during the flushing task--1421 ppm and 2522 ppm--were above the NIOSH short-term exposure limit (STEL) of 1250 ppm. These data suggest the possibility that the STEL may be exceeded for tasks involving direct work with liquid FC 113. Peak exposure levels may be reduced by modification of worker position in the HLAF clean room and by use of open wire tables in the VLAF clean room.

Characterization of miR-122-independent propagation of HCV

PubMed Central

Motooka, Daisuke; Nakamura, Shota; Yamamoto, Satomi; Mori, Hiroyuki; Sato, Asuka; Uemura, Kentaro; Fauzyah, Yuzy; Suda, Takahiro; Nishio, Akira; Hmwe, Su Su; Okamoto, Toru; Tatsumi, Tomohide; Takehara, Tetsuo; Chayama, Kazuaki; Wakita, Takaji; Koike, Kazuhiko

2017-01-01

miR-122, a liver-specific microRNA, is one of the determinants for liver tropism of hepatitis C virus (HCV) infection. Although miR-122 is required for efficient propagation of HCV, we have previously shown that HCV replicates at a low rate in miR-122-deficient cells, suggesting that HCV-RNA is capable of propagating in an miR-122-independent manner. We herein investigated the roles of miR-122 in both the replication of HCV-RNA and the production of infectious particles by using miR-122-knockout Huh7 (Huh7-122KO) cells. A slight increase of intracellular HCV-RNA levels and infectious titers in the culture supernatants was observed in Huh7-122KO cells upon infection with HCV. Moreover, after serial passages of HCV in miR-122-knockout Huh7.5.1 cells, we obtained an adaptive mutant, HCV122KO, possessing G28A substitution in the 5’UTR of the HCV genotype 2a JFH1 genome, and this mutant may help to enhance replication complex formation, a possibility supported by polysome analysis. We also found the introduction of adaptive mutation around miR-122 binding site in the genotype 1b/2a chimeric virus, which originally had an adenine at the nucleotide position 29. HCV122KO exhibited efficient RNA replication in miR-122-knockout cells and non-hepatic cells without exogenous expression of miR-122. Competition assay revealed that the G28A mutant was dominant in the absence of miR-122, but its effects were equivalent to those of the wild type in the presence of miR-122, suggesting that the G28A mutation does not confer an advantage for propagation in miR-122-rich hepatocytes. These observations may explain the clinical finding that the positive rate of G28A mutation was higher in miR-122-deficient PBMCs than in the patient serum, which mainly included the hepatocyte-derived virus from HCV-genotype-2a patients. These results suggest that the emergence of HCV mutants that can propagate in non-hepatic cells in an miR-122-independent manner may participate in the induction of

38 CFR 21.122 - School course.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 2 2011-07-01 2011-07-01 false School course. 21.122... Educational and Vocational Training Services § 21.122 School course. (a) Explanation of terms—schools, educational institution, and institution. These terms mean any public or private school, secondary school...

38 CFR 21.122 - School course.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false School course. 21.122... Educational and Vocational Training Services § 21.122 School course. (a) Explanation of terms—schools, educational institution, and institution. These terms mean any public or private school, secondary school...

K2-113: a dense hot-Jupiter transiting a solar analogue

NASA Astrophysics Data System (ADS)

Espinoza, Néstor; Rabus, Markus; Brahm, Rafael; Jones, Matías; Jordán, Andrés; Rojas, Felipe; Drass, Holger; Vučković, Maja; Hartman, Joel D.; Jenkins, James S.; Cortés, Cristián

2017-11-01

We present the discovery of K2-113, a dense hot-Jupiter discovered using photometry from Campaign 8 of the Kepler-2 (K2) mission and high-resolution spectroscopic follow-up obtained with the FEROS spectrograph. The planet orbits a V = 13.68 solar analogue in a P=5.817 60^{+0.000 03}_{-0.000 03} d orbit, and has a radius of 0.93^{+0.10}_{-0.07}R_J and a mass of 1.29^{+0.13}_{-0.14}M_J. With a density of 1.97^{+0.60}_{-0.53} g cm-3, the planet is among the densest systems known having masses below 2 MJ and T_eq > 1000, and is just above the temperature limit at which inflation mechanisms are believed to start being important. Based on its mass and radius, we estimate that K2-113 should have a heavy element content of the order of ˜110 M⊕ or greater.

PPARγ suppresses the proliferation of cardiac myxoma cells through downregulation of MEF2D in a miR-122-dependent manner

DOE Office of Scientific and Technical Information (OSTI.GOV)

Qiu, Youzhu; Yang, Jie; Bian, Shizhu

2016-06-03

Peroxisome proliferator-activated receptor gamma (PPARγ), a multiple functional transcription factor, has been reported to have anti-tumor effects through inhibition of cells proliferation. However, its effects on cardiac myxoma (CM) cells and the underlying signaling mechanism is unclear. In the present study, we demonstrated that the level of PPARγ is inversely correlated with that of myocyte enhancer factor 2D (MEF2D), a biomarker of CM. We found that activation of PPARγ inhibit MEF2D expression via upregulation of miR-122, which can target the 3′-UTR of MEF2D and inhibit MEF2D expression, by directly binding to the PPRE in the miR-122 promoter region. Functional experimentsmore » further showed that miR-122-dependent downregulation of MEF2D by PPARγ suppress the proliferation of CM cells. These results suggest that PPARγ may exert its antiproliferative effects by negatively regulating the MEF2D in CM cells, which through upregulation of miR-122, and PPARγ/miR-122/MEF2D signaling pathway may be a novel target for treatment of CM. -- Highlights: •PPARγ expression is inversely correlated with MEF2D expression in CM tissues. •PPARγ downregulates MEF2D expression in CM cells. •PPARγ inhibits MEF2D expression via upregulation of miR-122. •miR-122-dependent downregulation of MEF2D by PPARγ suppresses the proliferation of CM cells.« less

19 CFR 181.122 - Disclosure to government authorities.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 19 Customs Duties 2 2014-04-01 2014-04-01 false Disclosure to government authorities. 181.122 Section 181.122 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY... Information § 181.122 Disclosure to government authorities. Nothing in § 181.121 of this part shall preclude...

32 CFR 219.122 - Use of Federal funds.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 2 2010-07-01 2010-07-01 false Use of Federal funds. 219.122 Section 219.122 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS PROTECTION OF HUMAN SUBJECTS § 219.122 Use of Federal funds. Federal funds administered by a...

18 CFR 401.113 - Segregable materials.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 18 Conservation of Power and Water Resources 2 2011-04-01 2011-04-01 false Segregable materials. 401.113 Section 401.113 Conservation of Power and Water Resources DELAWARE RIVER BASIN COMMISSION ADMINISTRATIVE MANUAL RULES OF PRACTICE AND PROCEDURE Public Access to Records and Information § 401.113...

10 CFR 71.113 - Document control.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 2 2013-01-01 2013-01-01 false Document control. 71.113 Section 71.113 Energy NUCLEAR....113 Document control. The licensee, certificate holder, and applicant for a CoC shall establish measures to control the issuance of documents such as instructions, procedures, and drawings, including...

10 CFR 71.113 - Document control.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 2 2014-01-01 2014-01-01 false Document control. 71.113 Section 71.113 Energy NUCLEAR....113 Document control. The licensee, certificate holder, and applicant for a CoC shall establish measures to control the issuance of documents such as instructions, procedures, and drawings, including...

10 CFR 71.113 - Document control.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 2 2010-01-01 2010-01-01 false Document control. 71.113 Section 71.113 Energy NUCLEAR....113 Document control. The licensee, certificate holder, and applicant for a CoC shall establish measures to control the issuance of documents such as instructions, procedures, and drawings, including...

21 CFR 133.113 - Cheddar cheese.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Cheddar cheese. 133.113 Section 133.113 Food and... CONSUMPTION CHEESES AND RELATED CHEESE PRODUCTS Requirements for Specific Standardized Cheese and Related Products § 133.113 Cheddar cheese. (a) Description. (1) Cheddar cheese is the food prepared by the...

21 CFR 133.113 - Cheddar cheese.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Cheddar cheese. 133.113 Section 133.113 Food and... CONSUMPTION CHEESES AND RELATED CHEESE PRODUCTS Requirements for Specific Standardized Cheese and Related Products § 133.113 Cheddar cheese. (a) Description. (1) Cheddar cheese is the food prepared by the...

MicroRNA-122 Influences the Development of Sperm Abnormalities from Human Induced Pluripotent Stem Cells by Regulating TNP2 Expression

PubMed Central

Huang, Yongyi; Liu, Jianjun; Zhao, Yanhui; Jiang, Lizhen; Huang, Qin

2013-01-01

Sperm abnormalities are one of the main factors responsible for male infertility; however, their pathogenesis remains unclear. The role of microRNAs in the development of sperm abnormalities in infertile men has not yet been investigated. Here, we used human induced pluripotent stem cells to investigate the influence of miR-122 expression on the differentiation of these cells into spermatozoa-like cells in vitro. After induction, mutant miR-122-transfected cells formed spermatozoa-like cells. Flow cytometry of DNA content revealed a significant increase in the haploid cell population in spermatozoa-like cells derived from mutant miR-122-transfected cells as compared to those derived from miR-122-transfected cells. During induction, TNP2 and protamine mRNA and protein levels were significantly higher in mutant miR-122-transfected cells than in miR-122-transfected cells. High-throughput isobaric tags for relative and absolute quantification were used to identify and quantify the different protein expression levels in miR-122- and mutant miR-122-transfected cells. Among all the proteins analyzed, the expression of lipoproteins, for example, APOB and APOA1, showed the most significant difference between the two groups. This study illustrates that miR-122 expression is associated with abnormal sperm development. MiR-122 may influence spermatozoa-like cells by suppressing TNP2 expression and inhibiting the expression of proteins associated with sperm development. PMID:23327642

The Caspian Sea Catchment influenced by Atlantic Teleconnections in CESM1.2.2 and Observations

NASA Astrophysics Data System (ADS)

Nandini, S. D.; Prange, M.; Schulz, M.

2017-12-01

The Caspian Sea (CS) is the world's largest inland sea and located within a closed (endorheic) drainage basin [ 37°-47N, 47°-54°E]. It has undergone dynamic variations (>3 m) during the past century with huge impacts on the economy, ecosystem and livelihood of coastal people. The origin of these variations as well as future changes are disputable. Here, we examine the impact of the major seasonal North Atlantic teleconnection patterns, the North Atlantic Oscillation (NAO) and the East Atlantic pattern (EA) on Caspian hydroclimate variability from 1850-2100 CE. Five Numerical experiments at different atmospheric grid resolutions (2° and 1°) and atmospheric model versions (CAM4 and CAM5) are carried out with the coupled Community Earth System Model (CESM1.2.2). Results reveal the 1° CESM1.2.2 CAM5 captures DJF NAO (46.5%) and EA (13.4%), agreeing well with observational data (1850-2000). The DJF NAO has a strong influence on the DJF temperature, rainfall and evaporation minus precipitation (E-P) over the Caspian sub-basins (Volga, Ural, Terek and Kura). Furthermore, 1° model climate projections (2020-2100 CE) are performed with different Representative Concentration Pathways (RCP4.5 and RCP8.5) to examine likely changes in the NAO and EA and their influence on the Caspian catchment. The NAO under the RCP4.5 and RCP8.5 scenarios remains the leading mode with the highest variance and influences E-P with increased precipitation over the Volga basin and increased evaporation over the Caspian Sea. The above canceling effects act on the hydroclimate variability in the Caspian sub-basins. Moreover, it is indicated that no substantial change is predicted in the CSL by the year 2100. Keywords: North Atlantic Oscillation (NAO), CESM1.2.2 resolutions, Evaporation minus Precipitation (E-P), RCP4.5, RCP8.5

27 CFR 41.122 - Strengthening bond.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 27 Alcohol, Tobacco Products and Firearms 2 2013-04-01 2013-04-01 false Strengthening bond. 41.122... States Deferred Payment of Tax in Puerto Rico on Tobacco Products § 41.122 Strengthening bond. Where the... shall immediately file a strengthening bond in an appropriate amount with the same surety as that on the...

27 CFR 41.122 - Strengthening bond.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 27 Alcohol, Tobacco Products and Firearms 2 2014-04-01 2014-04-01 false Strengthening bond. 41.122... States Deferred Payment of Tax in Puerto Rico on Tobacco Products § 41.122 Strengthening bond. Where the... shall immediately file a strengthening bond in an appropriate amount with the same surety as that on the...

27 CFR 41.122 - Strengthening bond.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false Strengthening bond. 41.122... States Deferred Payment of Tax in Puerto Rico on Tobacco Products § 41.122 Strengthening bond. Where the... shall immediately file a strengthening bond in an appropriate amount with the same surety as that on the...

27 CFR 41.122 - Strengthening bond.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 27 Alcohol, Tobacco Products and Firearms 2 2011-04-01 2011-04-01 false Strengthening bond. 41.122... States Deferred Payment of Tax in Puerto Rico on Tobacco Products § 41.122 Strengthening bond. Where the... shall immediately file a strengthening bond in an appropriate amount with the same surety as that on the...

27 CFR 41.122 - Strengthening bond.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 27 Alcohol, Tobacco Products and Firearms 2 2012-04-01 2011-04-01 true Strengthening bond. 41.122... States Deferred Payment of Tax in Puerto Rico on Tobacco Products § 41.122 Strengthening bond. Where the... shall immediately file a strengthening bond in an appropriate amount with the same surety as that on the...

VIEW LOOKING SOUTHWEST AT BUILDING 122 DURING CONSTRUCTION. BUILDING 122, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

VIEW LOOKING SOUTHWEST AT BUILDING 122 DURING CONSTRUCTION. BUILDING 122, THE EMERGENCY MEDICAL BUILDING, WAS ONE OF THE ORIGINAL STRUCTURES AT THE ROCKY FLATS PLANT. (5/29/52) - Rocky Flats Plant, Emergency Medical Services Facility, Southwest corner of Central & Third Avenues, Golden, Jefferson County, CO

19 CFR 122.33 - Place of first landing.

Code of Federal Regulations, 2014 CFR

2014-04-01

... Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE... international airport (see § 122.13), provided that permission to land has not been denied pursuant to § 122.12(c); (2) At a landing rights airport if permission to land has been granted (see § 122.14); or (3) At...

19 CFR 122.33 - Place of first landing.

Code of Federal Regulations, 2012 CFR

2012-04-01

... Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE... international airport (see § 122.13), provided that permission to land has not been denied pursuant to § 122.12(c); (2) At a landing rights airport if permission to land has been granted (see § 122.14); or (3) At...

19 CFR 122.33 - Place of first landing.

Code of Federal Regulations, 2013 CFR

2013-04-01

... Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE... international airport (see § 122.13), provided that permission to land has not been denied pursuant to § 122.12(c); (2) At a landing rights airport if permission to land has been granted (see § 122.14); or (3) At...

Variability of Neptune's 12.2-micron ethane emission feature

NASA Technical Reports Server (NTRS)

Hammel, H. B.; Young, Leslie A.; Hackwell, J.; Lynch, D. K.; Russell, R.; Orton, Glenn S.

1992-01-01

It is presently shown that the ratio of ethane emission to methane emission in Neptune's 7-14 micron spectrum increased by a factor of 1.47 +/- 0.11 in the period between 1985 and 1991, and that the 12.2-micron ethan feature (rather than that of methane at 7.7 microns) is implicated in the greater part of that change. It is speculated that this variation is due either to a nonuniform increase in stratospheric temperature, or (more likely) to an increase in the ethane concentration by over 15 percent.

38 CFR 75.113 - Data breach.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Data breach. 75.113 Section 75.113 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) INFORMATION SECURITY MATTERS Data Breaches § 75.113 Data breach. Consistent with the definition of data breach in § 75.112 of this subpart, a data breach...

New low-spin states of 122Xe observed via high-statistics β-decay of 122Cs

NASA Astrophysics Data System (ADS)

Jigmeddorj, B.; Garrett, P. E.; Andreoiu, C.; Ball, G. C.; Bruhn, T.; Cross, D. S.; Garnsworthy, A. B.; Hadinia, B.; Moukaddam, M.; Park, J.; Pore, J. L.; Radich, A. J.; Rajabali, M. M.; Rand, E. T.; Rizwan, U.; Svensson, C. E.; Voss, P.; Wang, Z. M.; Wood, J. L.; Yates, S. W.

2018-05-01

Excited states of 122Xe were studied via the β+/EC decay of 122Cs with the 8π γ-ray spectrometer at the TRIUMF-ISAC facility. Compton-suppressed HPGe detectors were used for measurements of γ-ray intensities, γγ coincidences, and γ-γ angular correlations. Two sets of data were collected to optimize the decays of the ground (21.2 s) and isomeric (3.7 min) states of 122Cs. The data collected have enabled the observation of about 505 new transitions and about 250 new levels, including 51 new low-spin states. Spin assignments have been made for 58 low-spin states based on the deduced β-decay feeding and γ-γ angular correlation analyses.

THG113.31, a specific PGF2alpha receptor antagonist, induces human myometrial relaxation and BKCa channel activation

PubMed Central

Doheny, Helen C; O'Reilly, Michael J; Sexton, Donal J; Morrison, John J

2007-01-01

Background PGF2alpha exerts a significant contractile effect on myometrium and is central to human labour. THG113.31, a specific non-competitive PGF2alpha receptor (FP) antagonist, exerts an inhibitory effect on myometrial contractility. The BKCa channel is ubiquitously encountered in human uterine tissue and plays a significant role in modulating myometrial cell membrane potential and excitability. The objective of this study was to investigate potential BKCa channel involvement in the response of human myometrium to THG113.31. Methods Single and whole-cell electrophysiological BKCa channel recordings from freshly dispersed myocytes, were investigated in the presence and absence of THG113.31. Functional studies investigated the effects of THG113.31 on isolated spontaneous myometrial contractions, in the presence and absence of the BKCa channel blocker, iberiotoxin. Results Single channel recordings identified the BKCa channel as a target of THG113.31. THG113.31 significantly increased the open state probability of these channels [control 0.023+/-0.006; 10 microM THG113.31 0.087+/-0.012 (P = 0.009); and 50 microM THG113.31 0.1356+/-0.018 (P = 0.001)]. In addition, THG113.31 increased whole-cell BKCa currents over a range of membrane potentials, and this effect was reversed by 100 nanoM IbTX. Isometric tension studies demonstrated that THG113.31 exerted a significant concentration-dependent relaxant effect on human myometrial tissue and pre-incubation of strips with IbTX abolished this effect on spontaneously occurring contractions. Conclusion These data suggests that activation of the BKCa channel may contribute, at least partially, to the uterorelaxant effect of THG113.31. PMID:17367527

5 CFR 831.113 - Payments to children.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 5 Administrative Personnel 2 2014-01-01 2014-01-01 false Payments to children. 831.113 Section 831.113 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) RETIREMENT Administration and General Provisions § 831.113 Payments to children. For purposes of...

5 CFR 831.113 - Payments to children.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Payments to children. 831.113 Section 831.113 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) RETIREMENT Administration and General Provisions § 831.113 Payments to children. For purposes of...

5 CFR 831.113 - Payments to children.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 5 Administrative Personnel 2 2012-01-01 2012-01-01 false Payments to children. 831.113 Section 831.113 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) RETIREMENT Administration and General Provisions § 831.113 Payments to children. For purposes of...

5 CFR 831.113 - Payments to children.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 5 Administrative Personnel 2 2011-01-01 2011-01-01 false Payments to children. 831.113 Section 831.113 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) RETIREMENT Administration and General Provisions § 831.113 Payments to children. For purposes of...

5 CFR 831.113 - Payments to children.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 5 Administrative Personnel 2 2013-01-01 2013-01-01 false Payments to children. 831.113 Section 831.113 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) RETIREMENT Administration and General Provisions § 831.113 Payments to children. For purposes of...

9 CFR 202.122 - Rule 22: Ex parte communications.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Rule 22: Ex parte communications. 202.122 Section 202.122 Animals and Animal Products GRAIN INSPECTION, PACKERS AND STOCKYARDS....122 Rule 22: Ex parte communications. (a) At no stage of the proceeding between its docketing and the...

Theoretical investigation of M@Pb122- and M@Sn122- Zintl clusters (M = Lrn+, Lun+, La3+, Ac3+ and n = 0, 1, 2, 3).

PubMed

Joshi, Meenakshi; Chandrasekar, Aditi; Ghanty, Tapan K

2018-06-06

The positions of lawrencium (Lr), lutetium (Lu), actinium (Ac) and lanthanum (La) in the periodic table have been a controversial topic for quite some time. According to studies carried out by different groups with their justifications, these elements may potentially be placed in the d-block, p-block or all four in a 15 element f-block. The present work looks into this issue from a new perspective, which involves encapsulation of these four elements into Zintl ion clusters, Pb122- and Sn122-, followed by the determination of the structural, thermodynamic and electronic properties of these endohedral M@Pb122- and M@Sn122- clusters (M = Lrn+, Lun+ with n = 0, 1, 2, 3) using first principles based density functional theory (DFT). These parameters are compared with similar clusters encapsulated La3+ and Ac3+ ions in order to seek out similarities and differences to draw conclusions about their placement in the periodic table. For the first time the structural, energetic, and electronic properties of these metal atom/ion encapsulated Pb122- and Sn122- clusters have been investigated thoroughly. Structural parameters such as bond distances, geometry and symmetry, electronic properties viz. the density of states, the molecular orbital ordering, the electron localization function, bond critical point properties and charge distributions have been analyzed. Additionally, the thermodynamic property of the binding energy during the encapsulation process has also been calculated. All M@Pb12+ and M@Sn12+ (M = Lr and Lu) clusters form stable 18 bonding electron magic number systems with shell closing. They show negative values of binding energy and relatively large HOMO-LUMO energy gaps indicating the stability of such clusters. All the calculated parameters for Lr encapsulated clusters closely match with the corresponding calculated parameters of Lu encapsulated clusters, confirming the similarity between Lr and Lu metal atoms in various oxidation states, though their atomic

21 CFR 113.5 - Current good manufacturing practice.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Current good manufacturing practice. 113.5 Section... CONTAINERS General Provisions § 113.5 Current good manufacturing practice. The criteria in §§ 113.10, 113.40..., methods, practices, and controls used by the commercial processor in the manufacture, processing, or...

33 CFR 175.113 - Launchers.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Launchers. 175.113 Section 175... SAFETY EQUIPMENT REQUIREMENTS Visual Distress Signals § 175.113 Launchers. (a) When a visual distress signal carried to meet the requirements of § 175.110 requires a launcher to activate, then a launcher...

33 CFR 175.113 - Launchers.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Launchers. 175.113 Section 175... SAFETY EQUIPMENT REQUIREMENTS Visual Distress Signals § 175.113 Launchers. (a) When a visual distress signal carried to meet the requirements of § 175.110 requires a launcher to activate, then a launcher...

33 CFR 175.113 - Launchers.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Launchers. 175.113 Section 175... SAFETY EQUIPMENT REQUIREMENTS Visual Distress Signals § 175.113 Launchers. (a) When a visual distress signal carried to meet the requirements of § 175.110 requires a launcher to activate, then a launcher...

33 CFR 175.113 - Launchers.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Launchers. 175.113 Section 175... SAFETY EQUIPMENT REQUIREMENTS Visual Distress Signals § 175.113 Launchers. (a) When a visual distress signal carried to meet the requirements of § 175.110 requires a launcher to activate, then a launcher...

33 CFR 175.113 - Launchers.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Launchers. 175.113 Section 175... SAFETY EQUIPMENT REQUIREMENTS Visual Distress Signals § 175.113 Launchers. (a) When a visual distress signal carried to meet the requirements of § 175.110 requires a launcher to activate, then a launcher...

113. JOB NO. 1347K, SHEET 2M, 1929, FORD MOTOR COMPANY; ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

113. JOB NO. 1347-K, SHEET 2M, 1929, FORD MOTOR COMPANY; BOILER HOUSE ASSEMBLY PLANT; SECTIONS - Ford Motor Company Long Beach Assembly Plant, Assembly Building, 700 Henry Ford Avenue, Long Beach, Los Angeles County, CA

STS-113 Flight Control Team Photo in WFCR - Orbit 2 with Flight Director John Curry.

NASA Image and Video Library

2002-11-27

JSC2002-02106 (27 November 2002) --- The members of the STS-113 Orbit 2 Team pose for a group portrait in the shuttle flight control room (WFCR) in Houston’s Mission Control Center (MCC). Flight Director John Curry stands to the left of the STS-113 mission logo and astronaut Lisa M. Nowak, spacecraft communicator (CAPCOM), stands to the left of Curry.

19 CFR 122.183 - Denial of access.

Code of Federal Regulations, 2010 CFR

2010-04-01

...-year period, or any longer period that the port director deems appropriate for the offense in question... suspension of access under § 122.182(g) or § 122.187; (2) Evidence of a pending or past investigation... punishable by a maximum term of imprisonment of more than one year; (xxvi) Violence at an airport serving...

33 CFR 127.113 - Warning signs.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Warning signs. 127.113 Section... Waterfront Facilities Handling Liquefied Natural Gas § 127.113 Warning signs. (a) The marine transfer area for LNG must have warning signs that— (1) Meet paragraph (b) of this section; (2) Can be seen from the...

33 CFR 127.113 - Warning signs.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Warning signs. 127.113 Section... Waterfront Facilities Handling Liquefied Natural Gas § 127.113 Warning signs. (a) The marine transfer area for LNG must have warning signs that— (1) Meet paragraph (b) of this section; (2) Can be seen from the...

33 CFR 127.113 - Warning signs.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Warning signs. 127.113 Section... Waterfront Facilities Handling Liquefied Natural Gas § 127.113 Warning signs. (a) The marine transfer area for LNG must have warning signs that— (1) Meet paragraph (b) of this section; (2) Can be seen from the...

33 CFR 127.113 - Warning signs.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Warning signs. 127.113 Section... Waterfront Facilities Handling Liquefied Natural Gas § 127.113 Warning signs. (a) The marine transfer area for LNG must have warning signs that— (1) Meet paragraph (b) of this section; (2) Can be seen from the...

33 CFR 127.113 - Warning signs.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Warning signs. 127.113 Section... Waterfront Facilities Handling Liquefied Natural Gas § 127.113 Warning signs. (a) The marine transfer area for LNG must have warning signs that— (1) Meet paragraph (b) of this section; (2) Can be seen from the...

7 CFR 1260.122 - Promotion.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 10 2010-01-01 2010-01-01 false Promotion. 1260.122 Section 1260.122 Agriculture... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE BEEF PROMOTION AND RESEARCH Beef Promotion and Research Order Definitions § 1260.122 Promotion. Promotion means any action, including paid...

40 CFR 122.37 - Will the small MS4 storm water program regulations at §§ 122.32 through 122.36 and § 123.35 of...

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 21 2010-07-01 2010-07-01 false Will the small MS4 storm water program regulations at §§ 122.32 through 122.36 and § 123.35 of this chapter change in the future? 122.37 Section 122.37 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS EPA ADMINISTERED PERMIT PROGRAMS: THE NATIONAL...

40 CFR 122.37 - Will the small MS4 storm water program regulations at §§ 122.32 through 122.36 and § 123.35 of...

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 22 2011-07-01 2011-07-01 false Will the small MS4 storm water program regulations at §§ 122.32 through 122.36 and § 123.35 of this chapter change in the future? 122.37 Section 122.37 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS EPA ADMINISTERED PERMIT PROGRAMS: THE NATIONAL...

9 CFR 122.1 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Definitions. 122.1 Section 122.1..., SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS ORGANISMS AND VECTORS § 122.1 Definitions... regulations. (g) Person. Any individual, firm, partnership, corporation, company, society, association, or...

25 CFR 122.3 - Information collection.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false Information collection. 122.3 Section 122.3 Indians... FUNDS FOR EDUCATION § 122.3 Information collection. (a) The information collection requirements... assistance grants. The information collected in § 122.9 provides summary review for program evaluation and...

9 CFR 113.305 - Canine Hepatitis and Canine Adenovirus Type 2 Vaccine.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Canine Hepatitis and Canine Adenovirus... STANDARD REQUIREMENTS Live Virus Vaccines § 113.305 Canine Hepatitis and Canine Adenovirus Type 2 Vaccine. Canine Hepatitis Vaccine and Canine Adenovirus Type 2 Vaccine shall be prepared from virus-bearing cell...

T cell receptor alpha variable 12-2 bias in the immunodominant response to Yellow fever virus.

PubMed

Bovay, Amandine; Zoete, Vincent; Dolton, Garry; Bulek, Anna M; Cole, David K; Rizkallah, Pierre J; Fuller, Anna; Beck, Konrad; Michielin, Olivier; Speiser, Daniel E; Sewell, Andrew K; Fuertes Marraco, Silvia A

2018-02-01

The repertoire of human αβ T-cell receptors (TCRs) is generated via somatic recombination of germline gene segments. Despite this enormous variation, certain epitopes can be immunodominant, associated with high frequencies of antigen-specific T cells and/or exhibit bias toward a TCR gene segment. Here, we studied the TCR repertoire of the HLA-A*0201-restricted epitope LLWNGPMAV (hereafter, A2/LLW) from Yellow Fever virus, which generates an immunodominant CD8 + T cell response to the highly effective YF-17D vaccine. We discover that these A2/LLW-specific CD8 + T cells are highly biased for the TCR α chain TRAV12-2. This bias is already present in A2/LLW-specific naïve T cells before vaccination with YF-17D. Using CD8 + T cell clones, we show that TRAV12-2 does not confer a functional advantage on a per cell basis. Molecular modeling indicated that the germline-encoded complementarity determining region (CDR) 1α loop of TRAV12-2 critically contributes to A2/LLW binding, in contrast to the conventional dominant dependence on somatically rearranged CDR3 loops. This germline component of antigen recognition may explain the unusually high precursor frequency, prevalence and immunodominance of T-cell responses specific for the A2/LLW epitope. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

7 CFR 1.22 - Authentication.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 1 2013-01-01 2013-01-01 false Authentication. 1.22 Section 1.22 Agriculture Office of the Secretary of Agriculture ADMINISTRATIVE REGULATIONS Official Records § 1.22 Authentication. When a request is received for an authenticated copy of a document that the agency determines to make...

19 CFR 122.114 - Contents.

Code of Federal Regulations, 2010 CFR

2012-04-01

... 19 Customs Duties 1 2012-04-01 2012-04-01 false Contents. 122.114 Section 122.114 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY AIR COMMERCE REGULATIONS Transit Air Cargo Manifest (TACM) Procedures § 122.114 Contents. (a) Form duplicates...

7 CFR 1.22 - Authentication.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 1 2010-01-01 2010-01-01 false Authentication. 1.22 Section 1.22 Agriculture Office of the Secretary of Agriculture ADMINISTRATIVE REGULATIONS Official Records § 1.22 Authentication. When a request is received for an authenticated copy of a document that the agency determines to make...

25 CFR 122.11 - Applicability.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false Applicability. 122.11 Section 122.11 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES MANAGEMENT OF OSAGE JUDGMENT FUNDS FOR EDUCATION § 122.11 Applicability. These regulations shall cease upon determination of the legal and...

7 CFR 946.122 - Reports.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 8 2014-01-01 2014-01-01 false Reports. 946.122 Section 946.122 Agriculture... Rules and Regulations Special Purpose Certificates § 946.122 Reports. Each handler shipping potatoes... report thereon showing the name and address of the shipper, car or truck number, Federal-State Inspection...

7 CFR 946.122 - Reports.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 8 2013-01-01 2013-01-01 false Reports. 946.122 Section 946.122 Agriculture... Rules and Regulations Special Purpose Certificates § 946.122 Reports. Each handler shipping potatoes... report thereon showing the name and address of the shipper, car or truck number, Federal-State Inspection...

7 CFR 966.122 - Reports.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 8 2014-01-01 2014-01-01 false Reports. 966.122 Section 966.122 Agriculture... Regulations Safeguards § 966.122 Reports. Each handler handling tomatoes under and pursuant to a Certificate of Privilege shall supply the committee with a report thereon within the time specified on the...

7 CFR 966.122 - Reports.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 8 2013-01-01 2013-01-01 false Reports. 966.122 Section 966.122 Agriculture... Regulations Safeguards § 966.122 Reports. Each handler handling tomatoes under and pursuant to a Certificate of Privilege shall supply the committee with a report thereon within the time specified on the...

33 CFR 136.113 - Other compensation.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Other compensation. 136.113 Section 136.113 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE POLLUTION FINANCIAL RESPONSIBILITY AND COMPENSATION OIL SPILL LIABILITY TRUST FUND; CLAIMS...

33 CFR 136.113 - Other compensation.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Other compensation. 136.113 Section 136.113 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE POLLUTION FINANCIAL RESPONSIBILITY AND COMPENSATION OIL SPILL LIABILITY TRUST FUND; CLAIMS...

33 CFR 136.113 - Other compensation.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Other compensation. 136.113 Section 136.113 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE POLLUTION FINANCIAL RESPONSIBILITY AND COMPENSATION OIL SPILL LIABILITY TRUST FUND; CLAIMS...

33 CFR 136.113 - Other compensation.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Other compensation. 136.113 Section 136.113 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE POLLUTION FINANCIAL RESPONSIBILITY AND COMPENSATION OIL SPILL LIABILITY TRUST FUND; CLAIMS...

33 CFR 136.113 - Other compensation.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Other compensation. 136.113 Section 136.113 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE POLLUTION FINANCIAL RESPONSIBILITY AND COMPENSATION OIL SPILL LIABILITY TRUST FUND; CLAIMS...

25 CFR 122.10 - Appeal.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false Appeal. 122.10 Section 122.10 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES MANAGEMENT OF OSAGE JUDGMENT FUNDS FOR EDUCATION § 122.10 Appeal. The procedure for appealing any decision regarding the awarding of funds under this...

Scientific travel in the Atlantic world: the French expedition to Gorée and the Antilles, 1681-1683.

PubMed

Dew, Nicholas

2010-03-01

Although historians have long recognized the importance of long-range scientific expeditions in both the practice and culture of eighteenth- and nineteenth-century science, it is less well understood how this form of scientific organization emerged and became established in the seventeenth and early eighteenth centuries. In the late seventeenth century new European scientific institutions tried to make use of globalized trade networks for their own ends, but to do so proved difficult. This paper offers a case history of one such expedition, the voyage sponsored by the French Académie royale des sciences to Gorée (in modern Senegal) and the Caribbean islands of Guadeloupe and Martinique in 1681-3. The voyage of Varin, Deshayes and de Glos reveals how the process of travel itself caused problems for instruments and observers alike.

5 CFR 185.122 - Discovery.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 5 Administrative Personnel 1 2012-01-01 2012-01-01 false Discovery. 185.122 Section 185.122... § 185.122 Discovery. (a) The following types of discovery are authorized: (1) Requests for production of..., discovery is available only as ordered by the ALJ. The ALJ shall regulate the timing of discovery. (d...

5 CFR 185.122 - Discovery.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false Discovery. 185.122 Section 185.122... § 185.122 Discovery. (a) The following types of discovery are authorized: (1) Requests for production of..., discovery is available only as ordered by the ALJ. The ALJ shall regulate the timing of discovery. (d...

5 CFR 185.122 - Discovery.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 5 Administrative Personnel 1 2013-01-01 2013-01-01 false Discovery. 185.122 Section 185.122... § 185.122 Discovery. (a) The following types of discovery are authorized: (1) Requests for production of..., discovery is available only as ordered by the ALJ. The ALJ shall regulate the timing of discovery. (d...

5 CFR 185.122 - Discovery.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Discovery. 185.122 Section 185.122... § 185.122 Discovery. (a) The following types of discovery are authorized: (1) Requests for production of..., discovery is available only as ordered by the ALJ. The ALJ shall regulate the timing of discovery. (d...

20 CFR 345.122 - Interest.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 20 Employees' Benefits 1 2014-04-01 2012-04-01 true Interest. 345.122 Section 345.122 Employees...' CONTRIBUTIONS AND CONTRIBUTION REPORTS Reporting and Collecting Contributions § 345.122 Interest. (a) Rate. If... this part, interest accrues at the rate of 1 percent per month, or fraction of a month. Interest on...

20 CFR 345.122 - Interest.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 20 Employees' Benefits 1 2012-04-01 2012-04-01 false Interest. 345.122 Section 345.122 Employees...' CONTRIBUTIONS AND CONTRIBUTION REPORTS Reporting and Collecting Contributions § 345.122 Interest. (a) Rate. If... this part, interest accrues at the rate of 1 percent per month, or fraction of a month. Interest on...

19 CFR 181.122 - Disclosure to government authorities.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 19 Customs Duties 2 2013-04-01 2013-04-01 false Disclosure to government authorities. 181.122 Section 181.122 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY... responsible for the administration and enforcement of determinations of origin and of customs and revenue...

19 CFR 181.122 - Disclosure to government authorities.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 19 Customs Duties 2 2011-04-01 2011-04-01 false Disclosure to government authorities. 181.122 Section 181.122 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY... responsible for the administration and enforcement of determinations of origin and of customs and revenue...

19 CFR 181.122 - Disclosure to government authorities.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 19 Customs Duties 2 2012-04-01 2012-04-01 false Disclosure to government authorities. 181.122 Section 181.122 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY... responsible for the administration and enforcement of determinations of origin and of customs and revenue...

19 CFR 122.114 - Contents.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 19 Customs Duties 1 2013-04-01 2013-04-01 false Contents. 122.114 Section 122.114 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY AIR COMMERCE REGULATIONS Transit Air Cargo Manifest (TACM) Procedures § 122.114 Contents. (a) Form duplicates original manifest. Each transit air cargo...

19 CFR 122.114 - Contents.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 19 Customs Duties 1 2014-04-01 2014-04-01 false Contents. 122.114 Section 122.114 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY AIR COMMERCE REGULATIONS Transit Air Cargo Manifest (TACM) Procedures § 122.114 Contents. (a) Form duplicates original manifest. Each transit air cargo...

19 CFR 122.114 - Contents.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 19 Customs Duties 1 2010-04-01 2010-04-01 false Contents. 122.114 Section 122.114 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY AIR COMMERCE REGULATIONS Transit Air Cargo Manifest (TACM) Procedures § 122.114 Contents. (a) Form duplicates original manifest. Each transit air cargo...

19 CFR 122.114 - Contents.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 19 Customs Duties 1 2011-04-01 2011-04-01 false Contents. 122.114 Section 122.114 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY AIR COMMERCE REGULATIONS Transit Air Cargo Manifest (TACM) Procedures § 122.114 Contents. (a) Form duplicates original manifest. Each transit air cargo...

25 CFR 122.7 - Budget.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false Budget. 122.7 Section 122.7 Indians BUREAU OF INDIAN... § 122.7 Budget. (a) By August 1 of each year, the Osage Tribal Education Committee will submit a proposed budget to the Assistant Secretary or to his/her designated representative for formal approval...

miR-122-SOCS1-JAK2 axis regulates allergic inflammation and allergic inflammation-promoted cellular interactions

PubMed Central

Kim, Hanearl; Kim, Hyuna; Byun, Jaehwan; Park, Yeongseo; Lee, Hansoo; Lee, Yun Sil; Choe, Jongseon; Kim, Young Myeong; Jeoung, Dooil

2017-01-01

The regulatory role of suppressor of cytokine signaling 1 (SOCS1) in inflammation has been reported. However, its role in allergic inflammation has not been previously reported. SOCS1 mediated in vitro and in vivo allergic inflammation. Histone deacetylase-3 (HDAC3), a mediator of allergic inflammation, interacted with SOCS1, and miR-384 inhibitor, a positive regulator of HDAC3, induced features of allergic inflammation in an SOCS1-dependent manner. miRNA array analysis showed that the expression of miR-122 was decreased by antigen-stimulation. TargetScan analysis predicted the binding of miR-122 to the 3′-UTR of SOCS1. miR-122 inhibitor induced in vitro and in vivo allergic features in SOCS1-dependent manner. SOCS1 was necessary for allergic inflammation-promoted enhanced tumorigenic and metastatic potential of cancer cells. SOCS1 and miR-122 regulated cellular interactions involving cancer cells, mast cells and macrophages during allergic inflammation. SOCS1 mimetic peptide, D-T-H-F-R-T-F-R-S-H-S-D-Y-R-R-I, inhibited in vitro and in vivo allergic inflammation, allergic inflammation-promoted enhanced tumorigenic and metastatic potential of cancer cells, and cellular interactions during allergic inflammation. Janus kinase 2 (JAK2) exhibited binding to SOCS1 mimetic peptide and mediated allergic inflammation. Transforming growth factor- Δ1 (TGF-Δ1) was decreased during allergic inflammation and showed an anti-allergic effect. SOCS1 and JAK2 regulated the production of anti-allergic TGF-Δ1. Taken together, our results show that miR-122-SOCS1 feedback loop can be employed as a target for the development of anti-allergic and anti-cancer drugs. PMID:28968979

21 CFR 113.81 - Product preparation.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Product preparation. 113.81 Section 113.81 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION THERMALLY PROCESSED LOW-ACID FOODS PACKAGED IN HERMETICALLY SEALED CONTAINERS...

18 CFR 401.113 - Segregable materials.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false Segregable materials. 401.113 Section 401.113 Conservation of Power and Water Resources DELAWARE RIVER BASIN COMMISSION... Segregable materials. Any reasonably segregable portion of a record shall be provided to any person...

18 CFR 401.113 - Segregable materials.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 18 Conservation of Power and Water Resources 2 2013-04-01 2012-04-01 true Segregable materials. 401.113 Section 401.113 Conservation of Power and Water Resources DELAWARE RIVER BASIN COMMISSION... Segregable materials. Any reasonably segregable portion of a record shall be provided to any person...

18 CFR 401.113 - Segregable materials.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 18 Conservation of Power and Water Resources 2 2014-04-01 2014-04-01 false Segregable materials. 401.113 Section 401.113 Conservation of Power and Water Resources DELAWARE RIVER BASIN COMMISSION... Segregable materials. Any reasonably segregable portion of a record shall be provided to any person...

18 CFR 401.113 - Segregable materials.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 18 Conservation of Power and Water Resources 2 2012-04-01 2012-04-01 false Segregable materials. 401.113 Section 401.113 Conservation of Power and Water Resources DELAWARE RIVER BASIN COMMISSION... Segregable materials. Any reasonably segregable portion of a record shall be provided to any person...

5 CFR 930.113 - Corrective action.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 5 Administrative Personnel 2 2011-01-01 2011-01-01 false Corrective action. 930.113 Section 930....113 Corrective action. An agency will take adverse, disciplinary, or other appropriate action against... such action against an operator or an incidental operator: (a) The employee is convicted of operating...

5 CFR 930.113 - Corrective action.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Corrective action. 930.113 Section 930....113 Corrective action. An agency will take adverse, disciplinary, or other appropriate action against... such action against an operator or an incidental operator: (a) The employee is convicted of operating...

32 CFR 219.122 - Use of Federal funds.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 2 2014-07-01 2014-07-01 false Use of Federal funds. 219.122 Section 219.122 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED... department or agency may not be expended for research involving human subjects unless the requirements of...

HNF-4α regulated miR-122 contributes to development of gluconeogenesis and lipid metabolism disorders in Type 2 diabetic mice and in palmitate-treated HepG2 cells.

PubMed

Wei, Shengnan; Zhang, Ming; Yu, Yang; Xue, Huan; Lan, Xiaoxin; Liu, Shuping; Hatch, Grant; Chen, Li

2016-11-15

Hepatocyte Nuclear Factor-4α (HNF-4α) is a key nuclear receptor protein required for liver development. miR-122 is a predominant microRNA expressed in liver and is involved in the regulation of cholesterol and fatty acid metabolism. HNF-4α is know to regulate expression of miR-122 in liver. We examined how HNF-4α regulated gluconeogenesis and lipid metabolism through miR-122 in vivo and in vitro. Expression of miR-122, HNF-4α, phosphoenolpyruvate carboxykinase (PEPCK), glucose-6-phosphatase (G6Pase), sterol response elementary binding protein-1 (SREBP-1), fatty acid synthase-1 (FAS-1), carnitine palmitoyltransferase-1 (CPT-1) and acetyl Coenzyme A carboxylase alpha (ACCα) were determined in livers of Type 2 diabetic mice and in insulin resistant palmitate-treated HepG2 cells. CPT-1 and phosphorylated ACCα expression were significantly decreased in livers of Type 2 diabetic mice and in palmitate-treated HepG2 cells compared to controls. In contrast, expression of miR-122, HNF-4α, PEPCK, G6Pase, SREBP-1, FAS-1 and ACCα were significantly elevated in liver of Type 2 diabetic mice and in palmitate-treated HepG2 cells compared to controls. Expression of HNF-4α increased whereas siRNA knockdown of HNF-4α decreased miR-122 levels in HepG2 cells compared to controls. In addition, expression of HNF-4α in HepG2 cells increased PEPCK, G6Pase, SREBP-1, FAS-1, ACCα mRNA and protein expression and decreased CPT-1 and p-ACCα mRNA and protein expression compared to controls. Addition of miR-122 inhibitors attenuated the HNF-4α mediated effect on expression of these gluconeogenic and lipid metabolism proteins. The results indicate that HNF-4α regulated miR-122 contributes to development of the gluconeogenic and lipid metabolism alterations observed in Type 2 diabetic mice and in palmitate-treated HepG2 cells. Copyright © 2016 Elsevier B.V. All rights reserved.

Intelligence Authorization Act for Fiscal Year 2014

THOMAS, 113th Congress

Rep. Rogers, Mike J. [R-MI-8

2013-10-30

House - 11/25/2013 Placed on the Union Calendar, Calendar No. 198. (All Actions) Notes: For further action, see S.1681, which became Public Law 113-126 on 7/7/2014. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

10 CFR 501.122 - Contents.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 4 2013-01-01 2013-01-01 false Contents. 501.122 Section 501.122 Energy DEPARTMENT OF ENERGY (CONTINUED) ALTERNATE FUELS ADMINISTRATIVE PROCEDURES AND SANCTIONS Requests for Stay § 501.122 Contents. (a) A petition for a stay shall contain a full and complete statement of all facts believed to be pertinent to the act or transaction for...

10 CFR 501.122 - Contents.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 4 2012-01-01 2012-01-01 false Contents. 501.122 Section 501.122 Energy DEPARTMENT OF ENERGY (CONTINUED) ALTERNATE FUELS ADMINISTRATIVE PROCEDURES AND SANCTIONS Requests for Stay § 501.122 Contents. (a) A petition for a stay shall contain a full and complete statement of all facts believed to be pertinent to the act or transaction for...

10 CFR 501.122 - Contents.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 4 2014-01-01 2014-01-01 false Contents. 501.122 Section 501.122 Energy DEPARTMENT OF ENERGY (CONTINUED) ALTERNATE FUELS ADMINISTRATIVE PROCEDURES AND SANCTIONS Requests for Stay § 501.122 Contents. (a) A petition for a stay shall contain a full and complete statement of all facts believed to be pertinent to the act or transaction for...

10 CFR 501.122 - Contents.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Contents. 501.122 Section 501.122 Energy DEPARTMENT OF ENERGY (CONTINUED) ALTERNATE FUELS ADMINISTRATIVE PROCEDURES AND SANCTIONS Requests for Stay § 501.122 Contents. (a) A petition for a stay shall contain a full and complete statement of all facts believed to be pertinent to the act or transaction for...

10 CFR 501.122 - Contents.

Code of Federal Regulations, 2010 CFR

2007-01-01

... 10 Energy 4 2007-01-01 2007-01-01 false Contents. 501.122 Section 501.122 Energy DEPARTMENT OF ENERGY (CONTINUED) ALTERNATE FUELS ADMINISTRATIVE PROCEDURES AND SANCTIONS Requests for Stay § 501.122 Contents. (a) A petition for a stay shall contain a full and complete statement of all facts believed to be pertinent to the act or transaction for...

10 CFR 501.122 - Contents.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 4 2011-01-01 2011-01-01 false Contents. 501.122 Section 501.122 Energy DEPARTMENT OF ENERGY (CONTINUED) ALTERNATE FUELS ADMINISTRATIVE PROCEDURES AND SANCTIONS Requests for Stay § 501.122 Contents. (a) A petition for a stay shall contain a full and complete statement of all facts believed to be pertinent to the act or transaction for...

13 CFR 113.310 - Recruitment.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Recruitment. 113.310 Section 113... Discrimination on the Basis of Sex in Admission and Recruitment Prohibited § 113.310 Recruitment. (a) Nondiscriminatory recruitment. A recipient to which §§ 113.300 through 113.310 apply shall not discriminate on the...

20 CFR 655.122 - Contents of job offers.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Contents of job offers. 655.122 Section 655.122 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR TEMPORARY EMPLOYMENT OF FOREIGN WORKERS IN THE UNITED STATES Labor Certification Process for Temporary Agricultural Employment in the United States (H-2A Workers)...

Recoil distance lifetime measurements in 122,124Xe

NASA Astrophysics Data System (ADS)

Govil, I. M.; Kumar, A.; Iyer, H.; Li, H.; Garg, U.; Ghugre, S. S.; Johnson, T.; Kaczarowski, R.; Kharraja, B.; Naguleswaran, S.; Walpe, J. C.

1998-02-01

Lifetimes of the lower-excited states in 122,124Xe are measured using the recoil-distance Doppler-shift technique. The reactions 110Pd(16O,4n)122Xe and 110Pd(18O,4n)124Xe at a beam energy of 66 MeV were used for this experiment. The lifetimes of the 2+, 4+, 6+, and 8+ states of the ground state band were extracted using the computer code LIFETIME including the corrections due to the side feeding and the nuclear deorientation effects. The lifetime of the 2+ state in 122Xe agrees with the recoil distance method (RDM) measurements but for the 124Xe it does not agree with the RDM measurements but agrees with the Coulomb-excitation experiment. The measured B(E2) values for both the nuclei are compared with the standard algebraic and the multishell models.

FUNCTIONAL CHARACTERIZATION OF THE A411T (L137F) and G364A (D122N) GENETIC POLYMORPHISMS IN HUMAN N-ACETYLTRANSFERASE 2

PubMed Central

Zang, Yu; Zhao, Shuang; Doll, Mark A.; States, J Christopher; Hein, David W.

2007-01-01

Human N-acetyltransferase 2 (NAT2) genetic polymorphisms may modify drug efficacy and toxicity and individual cancer susceptibility from carcinogen exposure. A411T (L137F) and G364A (D122N) are two single nucleotide polymorphisms (SNPs) that coexist with other SNPs in human NAT2 alleles NAT2*5I and NAT2*12D, respectively. Cloning and expression in COS-1 cells showed that both A411T and G364A reduced NAT2 immunoreactive protein to an undetectable level without causing changes in mRNA level. Missense mutants displayed different effects on sulfamethazine N-acetylation activity for both L137 (wild-type: 70.2±5.2; L137F: 1.34±0.03; L137W: non-detectable; L137I: 34.2±2.0; L137G: 0.52±0.04 nmol/min/mg) and D122 (wildtype: 70.2±5.2; D122R: non-detectable; D122Q: non-detectable; D122E: 1.72±0.24 nmol/min/mg). To further test our hypothesis that A411T (L137F) and G364A (D122N) accelerate protein degradation, various NAT2 alleles were cloned and expressed in E. coli, which does not possess the ubiquitin-mediated degradation pathway. In contrast to the expression in mammalian cells, recombinant NAT2 possessing either of these two SNPs showed no reduction in immunoreactive NAT2 level when expressed in E. coli. These findings suggest that both A411T (L137F) and G364A (D122N) enhance NAT2 degradation, resulting in reduced NAT2 protein and catalytic activity for NAT2 5I and NAT2 12D. PMID:17264801

20 CFR 655.122 - Contents of job offers.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 20 Employees' Benefits 3 2014-04-01 2014-04-01 false Contents of job offers. 655.122 Section 655... Employment in the United States (H-2A Workers) Prefiling Procedures § 655.122 Contents of job offers. (a) Prohibition against preferential treatment of aliens. The employer's job offer must offer to U.S. workers no...

20 CFR 655.122 - Contents of job offers.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 20 Employees' Benefits 3 2012-04-01 2012-04-01 false Contents of job offers. 655.122 Section 655... Employment in the United States (H-2A Workers) Prefiling Procedures § 655.122 Contents of job offers. (a) Prohibition against preferential treatment of aliens. The employer's job offer must offer to U.S. workers no...

20 CFR 655.122 - Contents of job offers.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 20 Employees' Benefits 3 2013-04-01 2013-04-01 false Contents of job offers. 655.122 Section 655... Employment in the United States (H-2A Workers) Prefiling Procedures § 655.122 Contents of job offers. (a) Prohibition against preferential treatment of aliens. The employer's job offer must offer to U.S. workers no...

SUBSURFACE PROPERTY RIGHTS: IMPLICATIONS FOR GEOLOGIC CO2 STORAGE

EPA Science Inventory

The paper discusses subsurface property rights as they apply to geologic sequestration (GS) of carbon dioxide (CO2). GS projects inject captured CO2 into deep (greater than ~1 km) geologic formations for the explicit purpose of avoiding atmospheric emission of CO2. Because of the...

SUBSURFACE PROPERTY RIGHTS: IMPLICATIONS FOR GEOLOGIC CO2 SEQUESTRATION

EPA Science Inventory

The chapter discusses subsurface property rights as they apply to geologic sequestration (GS) of carbon dioxide (CO2). GS projects inject captured CO2 into deep (greater than ~1 km) geologic formations for the explicit purpose of avoiding atmospheric emission of CO2. Because of t...

Publications - RI 2014-2 | Alaska Division of Geological & Geophysical

Science.gov Websites

content DGGS RI 2014-2 Publication Details Title: Geologic context, age constraints, and sedimentology of Gillis, R.J., 2014, Geologic context, age constraints, and sedimentology of a Pleistocene volcaniclastic 362.0 K Metadata - Read me Keywords Age Dates; Alluvial; Alluvial Deposits; Bedrock; Bedrock Geology

10 CFR 110.113 - Commission action.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 2 2010-01-01 2010-01-01 false Commission action. 110.113 Section 110.113 Energy NUCLEAR... Commission action. (a) Upon completion of a hearing, the Commission will issue a written opinion including... hearing issues; and (4) Take other action, as appropriate. [43 FR 21641, May 19, 1978, as amended at 64 FR...

10 CFR 110.113 - Commission action.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 2 2011-01-01 2011-01-01 false Commission action. 110.113 Section 110.113 Energy NUCLEAR... Commission action. (a) Upon completion of a hearing, the Commission will issue a written opinion including... hearing issues; and (4) Take other action, as appropriate. [43 FR 21641, May 19, 1978, as amended at 64 FR...

46 CFR 113.30-3 - Means of communications.

Code of Federal Regulations, 2010 CFR

2010-10-01

... equipment; and (2) Provide common talking means of two-way voice communication and calling among the... positions listed in § 113.30-5. (b) The means of communication and calling must be a reliable means of voice... 46 Shipping 4 2010-10-01 2010-10-01 false Means of communications. 113.30-3 Section 113.30-3...

40 CFR 60.122 - Standard for particulate matter.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 7 2014-07-01 2014-07-01 false Standard for particulate matter. 60.122... Smelters § 60.122 Standard for particulate matter. (a) On and after the date on which the performance test... furnace any gases which: (1) Contain particulate matter in excess of 50 mg/dscm (0.022 gr/dscf). (2...

40 CFR 60.122 - Standard for particulate matter.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 7 2012-07-01 2012-07-01 false Standard for particulate matter. 60.122... Smelters § 60.122 Standard for particulate matter. (a) On and after the date on which the performance test... furnace any gases which: (1) Contain particulate matter in excess of 50 mg/dscm (0.022 gr/dscf). (2...

40 CFR 60.122 - Standard for particulate matter.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 6 2011-07-01 2011-07-01 false Standard for particulate matter. 60.122... Smelters § 60.122 Standard for particulate matter. (a) On and after the date on which the performance test... furnace any gases which: (1) Contain particulate matter in excess of 50 mg/dscm (0.022 gr/dscf). (2...

40 CFR 60.122 - Standard for particulate matter.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 6 2010-07-01 2010-07-01 false Standard for particulate matter. 60.122... Smelters § 60.122 Standard for particulate matter. (a) On and after the date on which the performance test... furnace any gases which: (1) Contain particulate matter in excess of 50 mg/dscm (0.022 gr/dscf). (2...

40 CFR 60.122 - Standard for particulate matter.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 7 2013-07-01 2013-07-01 false Standard for particulate matter. 60.122... Smelters § 60.122 Standard for particulate matter. (a) On and after the date on which the performance test... furnace any gases which: (1) Contain particulate matter in excess of 50 mg/dscm (0.022 gr/dscf). (2...

7 CFR 1703.122 - Matching contributions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 11 2010-01-01 2010-01-01 false Matching contributions. 1703.122 Section 1703.122 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE RURAL DEVELOPMENT Distance Learning and Telemedicine Grant Program § 1703.122 Matching...

7 CFR 1703.122 - Matching contributions.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 11 2014-01-01 2014-01-01 false Matching contributions. 1703.122 Section 1703.122 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE RURAL DEVELOPMENT Distance Learning and Telemedicine Grant Program § 1703.122 Matching...

7 CFR 1703.122 - Matching contributions.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 11 2013-01-01 2013-01-01 false Matching contributions. 1703.122 Section 1703.122 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE RURAL DEVELOPMENT Distance Learning and Telemedicine Grant Program § 1703.122 Matching...

7 CFR 1703.122 - Matching contributions.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 11 2012-01-01 2012-01-01 false Matching contributions. 1703.122 Section 1703.122 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE RURAL DEVELOPMENT Distance Learning and Telemedicine Grant Program § 1703.122 Matching...

miRNA-122 Protects Mice and Human Hepatocytes from Acetaminophen Toxicity by Regulating Cytochrome P450 Family 1 Subfamily A Member 2 and Family 2 Subfamily E Member 1 Expression.

PubMed

Chowdhary, Vivek; Teng, Kun-Yu; Thakral, Sharda; Zhang, Bo; Lin, Cho-Hao; Wani, Nissar; Bruschweiler-Li, Lei; Zhang, Xiaoli; James, Laura; Yang, Dakai; Junge, Norman; Brüschweiler, Rafael; Lee, William M; Ghoshal, Kalpana

2017-12-01

Acetaminophen toxicity is a leading cause of acute liver failure (ALF). We found that miRNA-122 (miR-122) is down-regulated in liver biopsy specimens of patients with ALF and in acetaminophen-treated mice. A marked decrease in the primary miR-122 expression occurs in mice on acetaminophen overdose because of suppression of its key transactivators, hepatocyte nuclear factor (HNF)-4α and HNF6. More importantly, the mortality rates of male and female liver-specific miR-122 knockout (LKO) mice were significantly higher than control mice when injected i.p. with an acetaminophen dose not lethal to the control. LKO livers exhibited higher basal expression of cytochrome P450 family 2 subfamily E member 1 (CYP2E1) and cytochrome P450 family 1 subfamily A member 2 (CYP1A2) that convert acetaminophen to highly reactive N-acetyl-p-benzoquinone imine. Upregulation of Cyp1a2 primary transcript and mRNA in LKO mice correlated with the elevation of aryl hydrocarbon receptor (AHR) and mediator 1 (MED1), two transactivators of Cyp1a2. Analysis of ChIP-seq data in the ENCODE (Encyclopedia of DNA Element) database identified association of CCCTC-binding factor (CTCF) with Ahr promoter in mouse livers. Both MED1 and CTCF are validated conserved miR-122 targets. Furthermore, depletion of Ahr, Med1, or Ctcf in Mir122 -/- hepatocytes reduced Cyp1a2 expression. Pulse-chase studies found that CYP2E1 protein level is upregulated in LKO hepatocytes. Notably, miR-122 depletion sensitized differentiated human HepaRG cells to acetaminophen toxicity that correlated with upregulation of AHR, MED1, and CYP1A2 expression. Collectively, these results reveal a critical role of miR-122 in acetaminophen detoxification and implicate its therapeutic potential in patients with ALF. Copyright © 2017 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

25 CFR 122.3 - Information collection.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 25 Indians 1 2014-04-01 2014-04-01 false Information collection. 122.3 Section 122.3 Indians... FUNDS FOR EDUCATION § 122.3 Information collection. (a) The information collection requirements... et seq. and assigned clearance numbers 1076-0098 and 1076-0106, respectively. The information...

7 CFR 1924.122 - Exception authority.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 12 2010-01-01 2010-01-01 false Exception authority. 1924.122 Section 1924.122 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS... REGULATIONS CONSTRUCTION AND REPAIR Planning and Performing Site Development Work § 1924.122 Exception...

42 CFR 421.122 - Performance standards.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 3 2013-10-01 2013-10-01 false Performance standards. 421.122 Section 421.122... (CONTINUED) MEDICARE PROGRAM (CONTINUED) MEDICARE CONTRACTING Intermediaries § 421.122 Performance standards. (a) Development of standards. In addition to the performance criteria (§ 421.120), CMS develops...

42 CFR 421.122 - Performance standards.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 3 2012-10-01 2012-10-01 false Performance standards. 421.122 Section 421.122... (CONTINUED) MEDICARE PROGRAM (CONTINUED) MEDICARE CONTRACTING Intermediaries § 421.122 Performance standards. (a) Development of standards. In addition to the performance criteria (§ 421.120), CMS develops...

42 CFR 421.122 - Performance standards.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 3 2011-10-01 2011-10-01 false Performance standards. 421.122 Section 421.122... (CONTINUED) MEDICARE PROGRAM MEDICARE CONTRACTING Intermediaries § 421.122 Performance standards. (a) Development of standards. In addition to the performance criteria (§ 421.120), CMS develops detailed...

42 CFR 421.122 - Performance standards.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 3 2014-10-01 2014-10-01 false Performance standards. 421.122 Section 421.122... (CONTINUED) MEDICARE PROGRAM (CONTINUED) MEDICARE CONTRACTING Intermediaries § 421.122 Performance standards. (a) Development of standards. In addition to the performance criteria (§ 421.120), CMS develops...

38 CFR 75.113 - Data breach.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 2 2012-07-01 2012-07-01 false Data breach. 75.113...) INFORMATION SECURITY MATTERS Data Breaches § 75.113 Data breach. Consistent with the definition of data breach in § 75.112 of this subpart, a data breach occurs under this subpart if there is a loss or theft of...

38 CFR 75.113 - Data breach.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 2 2014-07-01 2014-07-01 false Data breach. 75.113...) INFORMATION SECURITY MATTERS Data Breaches § 75.113 Data breach. Consistent with the definition of data breach in § 75.112 of this subpart, a data breach occurs under this subpart if there is a loss or theft of...

38 CFR 75.113 - Data breach.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 2 2013-07-01 2013-07-01 false Data breach. 75.113...) INFORMATION SECURITY MATTERS Data Breaches § 75.113 Data breach. Consistent with the definition of data breach in § 75.112 of this subpart, a data breach occurs under this subpart if there is a loss or theft of...

38 CFR 75.113 - Data breach.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 2 2011-07-01 2011-07-01 false Data breach. 75.113...) INFORMATION SECURITY MATTERS Data Breaches § 75.113 Data breach. Consistent with the definition of data breach in § 75.112 of this subpart, a data breach occurs under this subpart if there is a loss or theft of...

19 CFR 122.173 - Application procedures.

Code of Federal Regulations, 2014 CFR

2014-04-01

... that it has developed and will continue to maintain standard operating procedures (SOP) which are... 19 Customs Duties 1 2014-04-01 2014-04-01 false Application procedures. 122.173 Section 122.173... TREASURY AIR COMMERCE REGULATIONS Air Carrier Smuggling Prevention Program § 122.173 Application procedures...

19 CFR 122.173 - Application procedures.

Code of Federal Regulations, 2011 CFR

2011-04-01

... that it has developed and will continue to maintain standard operating procedures (SOP) which are... 19 Customs Duties 1 2011-04-01 2011-04-01 false Application procedures. 122.173 Section 122.173... TREASURY AIR COMMERCE REGULATIONS Air Carrier Smuggling Prevention Program § 122.173 Application procedures...

19 CFR 122.173 - Application procedures.

Code of Federal Regulations, 2010 CFR

2010-04-01

... that it has developed and will continue to maintain standard operating procedures (SOP) which are... 19 Customs Duties 1 2010-04-01 2010-04-01 false Application procedures. 122.173 Section 122.173... TREASURY AIR COMMERCE REGULATIONS Air Carrier Smuggling Prevention Program § 122.173 Application procedures...

19 CFR 122.173 - Application procedures.

Code of Federal Regulations, 2012 CFR

2012-04-01

... that it has developed and will continue to maintain standard operating procedures (SOP) which are... 19 Customs Duties 1 2012-04-01 2012-04-01 false Application procedures. 122.173 Section 122.173... TREASURY AIR COMMERCE REGULATIONS Air Carrier Smuggling Prevention Program § 122.173 Application procedures...

19 CFR 122.173 - Application procedures.

Code of Federal Regulations, 2013 CFR

2013-04-01

... that it has developed and will continue to maintain standard operating procedures (SOP) which are... 19 Customs Duties 1 2013-04-01 2013-04-01 false Application procedures. 122.173 Section 122.173... TREASURY AIR COMMERCE REGULATIONS Air Carrier Smuggling Prevention Program § 122.173 Application procedures...

Publications - RI 2013-2 | Alaska Division of Geological & Geophysical

Science.gov Websites

content DGGS RI 2013-2 Publication Details Title: Surficial-geologic map of the Livengood area, central Burns, P.A.C., 2013, Surficial-geologic map of the Livengood area, central Alaska: Alaska Division of Sheet 1 Surficial-geologic map of the Livengood area, central Alaska, scale 1:50,000 (30.0 M) Digital

16p11.2–p12.2 duplication syndrome; a genomic condition differentiated from euchromatic variation of 16p11.2

PubMed Central

Barber, John C K; Hall, Victoria; Maloney, Viv K; Huang, Shuwen; Roberts, Angharad M; Brady, Angela F; Foulds, Nicki; Bewes, Beverley; Volleth, Marianne; Liehr, Thomas; Mehnert, Karl; Bateman, Mark; White, Helen

2013-01-01

Chromosome 16 contains multiple copy number variations (CNVs) that predispose to genomic disorders. Here, we differentiate pathogenic duplications of 16p11.2–p12.2 from microscopically similar euchromatic variants of 16p11.2. Patient 1 was a girl of 18 with autism, moderate intellectual disability, behavioural difficulties, dysmorphic features and a 7.71-Mb (megabase pair) duplication (16:21 521 005–29 233 146). Patient 2 had a 7.81-Mb duplication (16:21 382 561–29 191 527), speech delay and obsessional behaviour as a boy and, as an adult, short stature, macrocephaly and mild dysmorphism. The duplications contain 65 coding genes of which Polo-like kinase 1 (PLK1) has the highest likelihood of being haploinsufficient and, by implication, a triplosensitive gene. An additional 1.11-Mb CNV of 10q11.21 in Patient 1 was a possible modifier containing the G-protein-regulated inducer of neurite growth 2 (GPRIN2) gene. In contrast, the euchromatic variants in Patients 3 and 4 were amplifications from a 945-kb region containing non-functional immunoglobulin heavy chain (IGHV), hect domain pseudogene (HERC2P4) and TP53-inducible target gene 3 (TP53TG3) loci in proximal 16p11.2 (16:31 953 353–32 898 635). Paralogous pyrosequencing gave a total copy number of 3–8 in controls and 8 to >10 in Patients 3 and 4. The 16p11.2–p12.2 duplication syndrome is a recurrent genomic disorder with a variable phenotype including developmental delay, dysmorphic features, mild to severe intellectual disability, autism, obsessive or stereotyped behaviour, short stature and anomalies of the hands and fingers. It is important to differentiate pathogenic 16p11.2–p12.2 duplications from harmless, microscopically similar euchromatic variants of proximal 16p11.2, especially at prenatal diagnosis. PMID:22828807

19 CFR 122.167 - Aviation smuggling.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 19 Customs Duties 1 2010-04-01 2010-04-01 false Aviation smuggling. 122.167 Section 122.167 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY AIR COMMERCE REGULATIONS Penalties § 122.167 Aviation smuggling. (a) Civil penalties. Any aircraft...

19 CFR 122.167 - Aviation smuggling.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 19 Customs Duties 1 2011-04-01 2011-04-01 false Aviation smuggling. 122.167 Section 122.167 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY AIR COMMERCE REGULATIONS Penalties § 122.167 Aviation smuggling. (a) Civil penalties. Any aircraft...

19 CFR 122.167 - Aviation smuggling.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 19 Customs Duties 1 2012-04-01 2012-04-01 false Aviation smuggling. 122.167 Section 122.167 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY AIR COMMERCE REGULATIONS Penalties § 122.167 Aviation smuggling. (a) Civil penalties. Any aircraft...

19 CFR 122.167 - Aviation smuggling.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 19 Customs Duties 1 2013-04-01 2013-04-01 false Aviation smuggling. 122.167 Section 122.167 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY AIR COMMERCE REGULATIONS Penalties § 122.167 Aviation smuggling. (a) Civil penalties. Any aircraft...

19 CFR 122.167 - Aviation smuggling.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 19 Customs Duties 1 2014-04-01 2014-04-01 false Aviation smuggling. 122.167 Section 122.167 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY AIR COMMERCE REGULATIONS Penalties § 122.167 Aviation smuggling. (a) Civil penalties. Any aircraft...

7 CFR 762.122 - Loan limitations.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 7 2014-01-01 2014-01-01 false Loan limitations. 762.122 Section 762.122 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE SPECIAL PROGRAMS GUARANTEED FARM LOANS § 762.122 Loan limitations. (a) Dollar limits. The Agency will not...

29 CFR 1917.122 - Employee exits.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 7 2010-07-01 2010-07-01 false Employee exits. 1917.122 Section 1917.122 Labor Regulations...) MARINE TERMINALS Terminal Facilities § 1917.122 Employee exits. (a) Employee exits shall be clearly marked. (b) If an employee exit is not visible from employees' work stations, directional signs...

19 CFR 122.182 - Security provisions.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 19 Customs Duties 1 2014-04-01 2014-04-01 false Security provisions. 122.182 Section 122.182 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY AIR COMMERCE REGULATIONS Access to Customs Security Areas § 122.182 Security provisions. (a...

19 CFR 122.182 - Security provisions.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 19 Customs Duties 1 2013-04-01 2013-04-01 false Security provisions. 122.182 Section 122.182 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY AIR COMMERCE REGULATIONS Access to Customs Security Areas § 122.182 Security provisions. (a...

19 CFR 122.182 - Security provisions.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 19 Customs Duties 1 2012-04-01 2012-04-01 false Security provisions. 122.182 Section 122.182 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY AIR COMMERCE REGULATIONS Access to Customs Security Areas § 122.182 Security provisions. (a...

19 CFR 122.85 - Final airport.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 19 Customs Duties 1 2014-04-01 2014-04-01 false Final airport. 122.85 Section 122.85 Customs... AIR COMMERCE REGULATIONS Procedures for Residue Cargo and Stopover Passengers § 122.85 Final airport. When an aircraft enters at the last domestic airport of discharge, the traveling general declaration...

19 CFR 122.85 - Final airport.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 19 Customs Duties 1 2012-04-01 2012-04-01 false Final airport. 122.85 Section 122.85 Customs... AIR COMMERCE REGULATIONS Procedures for Residue Cargo and Stopover Passengers § 122.85 Final airport. When an aircraft enters at the last domestic airport of discharge, the traveling general declaration...

19 CFR 122.85 - Final airport.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 19 Customs Duties 1 2010-04-01 2010-04-01 false Final airport. 122.85 Section 122.85 Customs... AIR COMMERCE REGULATIONS Procedures for Residue Cargo and Stopover Passengers § 122.85 Final airport. When an aircraft enters at the last domestic airport of discharge, the traveling general declaration...

19 CFR 122.85 - Final airport.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 19 Customs Duties 1 2013-04-01 2013-04-01 false Final airport. 122.85 Section 122.85 Customs... AIR COMMERCE REGULATIONS Procedures for Residue Cargo and Stopover Passengers § 122.85 Final airport. When an aircraft enters at the last domestic airport of discharge, the traveling general declaration...

19 CFR 122.85 - Final airport.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 19 Customs Duties 1 2011-04-01 2011-04-01 false Final airport. 122.85 Section 122.85 Customs... AIR COMMERCE REGULATIONS Procedures for Residue Cargo and Stopover Passengers § 122.85 Final airport. When an aircraft enters at the last domestic airport of discharge, the traveling general declaration...

28 CFR 115.113 - Supervision and monitoring.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Supervision and monitoring. 115.113... NATIONAL STANDARDS Standards for Lockups Prevention Planning § 115.113 Supervision and monitoring. (a) For... heightened protection, to include continuous direct sight and sound supervision, single-cell housing, or...

28 CFR 115.113 - Supervision and monitoring.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Supervision and monitoring. 115.113... NATIONAL STANDARDS Standards for Lockups Prevention Planning § 115.113 Supervision and monitoring. (a) For... heightened protection, to include continuous direct sight and sound supervision, single-cell housing, or...

28 CFR 115.113 - Supervision and monitoring.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Supervision and monitoring. 115.113... NATIONAL STANDARDS Standards for Lockups Prevention Planning § 115.113 Supervision and monitoring. (a) For... heightened protection, to include continuous direct sight and sound supervision, single-cell housing, or...

STS-113 crew during M-113 armored personnel carrier training

NASA Technical Reports Server (NTRS)

2002-01-01

KENNEDY SPACE CENTER, FLA. -- The STS-113 crew pause for a photo after test drives in the M-113 armored personnel carrier behind them. From left are Mission Specialist Michael Lopez-Alegria, Pilot Paul Lockhart, Commander James Wetherbee and Mission Specialist John Herrington. Driving the M-113 is part of emergency egress training at the pad, one of the Terminal Countdown Demonstration Test activities in preparation for launch. The TCDT also includes a simulated launch countdown. The primary payloads on mission STS-113 are the first port truss segment, P1, and the Crew and Equipment Translation Aid (CETA) Cart B. Once delivered, the P1 truss will remain stowed until flight 12A.1 in 2003 when it will be attached to the central truss segment, S0, on the Space Station. Also onboard Space Shuttle Endeavour will be the Expedition 6 crew who will replace Expedition 5, returning to Earth after 4 months.

7 CFR 762.122 - Loan limitations.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 7 2010-01-01 2010-01-01 false Loan limitations. 762.122 Section 762.122 Agriculture... SPECIAL PROGRAMS GUARANTEED FARM LOANS § 762.122 Loan limitations. (a) Dollar limits. The Agency will not guarantee any loan that would result in the applicant's total indebtedness exceeding the limits established...

4 CFR 28.122 - Negotiability issues.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 4 Accounts 1 2010-01-01 2010-01-01 false Negotiability issues. 28.122 Section 28.122 Accounts... Special Procedures; Unfair Labor Practices § 28.122 Negotiability issues. Where the GAO and an exclusive... shall review the arguments, hold a hearing if the administrative judge deems it necessary, and issue a...

32 CFR 701.122 - Medical records.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 5 2014-07-01 2014-07-01 false Medical records. 701.122 Section 701.122... THE NAVY DOCUMENTS AFFECTING THE PUBLIC DON Privacy Program § 701.122 Medical records. (a) Health... requirements of DOD 6025.18-R. (b) Disclosure. DON activities shall disclose medical records to the individual...

32 CFR 701.122 - Medical records.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 5 2012-07-01 2012-07-01 false Medical records. 701.122 Section 701.122... THE NAVY DOCUMENTS AFFECTING THE PUBLIC DON Privacy Program § 701.122 Medical records. (a) Health... requirements of DOD 6025.18-R. (b) Disclosure. DON activities shall disclose medical records to the individual...

32 CFR 701.122 - Medical records.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 5 2013-07-01 2013-07-01 false Medical records. 701.122 Section 701.122... THE NAVY DOCUMENTS AFFECTING THE PUBLIC DON Privacy Program § 701.122 Medical records. (a) Health... requirements of DOD 6025.18-R. (b) Disclosure. DON activities shall disclose medical records to the individual...

46 CFR 122.510 - Emergency instructions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 4 2012-10-01 2012-10-01 false Emergency instructions. 122.510 Section 122.510 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS CARRYING MORE THAN 150... Emergencies § 122.510 Emergency instructions. (a) The master and crew of a vessel will be familiar with the...

46 CFR 122.510 - Emergency instructions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 4 2014-10-01 2014-10-01 false Emergency instructions. 122.510 Section 122.510 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS CARRYING MORE THAN 150... Emergencies § 122.510 Emergency instructions. (a) The master and crew of a vessel will be familiar with the...

49 CFR 1.22 - Deputy Secretary.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 1 2012-10-01 2012-10-01 false Deputy Secretary. 1.22 Section 1.22 Transportation Office of the Secretary of Transportation ORGANIZATION AND DELEGATION OF POWERS AND DUTIES Office of the Secretary Ost Officials § 1.22 Deputy Secretary. Along with the Secretary, the Deputy Secretary exercises...

49 CFR 1.22 - Deputy Secretary.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 1 2013-10-01 2013-10-01 false Deputy Secretary. 1.22 Section 1.22 Transportation Office of the Secretary of Transportation ORGANIZATION AND DELEGATION OF POWERS AND DUTIES Office of the Secretary Ost Officials § 1.22 Deputy Secretary. Along with the Secretary, the Deputy Secretary exercises...

49 CFR 1.22 - Deputy Secretary.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 1 2014-10-01 2014-10-01 false Deputy Secretary. 1.22 Section 1.22 Transportation Office of the Secretary of Transportation ORGANIZATION AND DELEGATION OF POWERS AND DUTIES Office of the Secretary Ost Officials § 1.22 Deputy Secretary. Along with the Secretary, the Deputy Secretary exercises...

7 CFR 4280.122 - Project eligibility.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 15 2010-01-01 2010-01-01 false Project eligibility. 4280.122 Section 4280.122... Efficiency Improvements Program Section B. Guaranteed Loans § 4280.122 Project eligibility. For a project to be eligible to receive a guaranteed loan under this subpart, the project must meet each of the...

21 CFR 139.122 - Enriched nonfat milk macaroni products.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Enriched nonfat milk macaroni products. 139.122 Section 139.122 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION MACARONI AND NOODLE PRODUCTS Requirements for Specific Standardized...

21 CFR 139.122 - Enriched nonfat milk macaroni products.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Enriched nonfat milk macaroni products. 139.122 Section 139.122 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION MACARONI AND NOODLE PRODUCTS Requirements for Specific Standardized...

46 CFR 122.420 - Crew training.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 4 2011-10-01 2011-10-01 false Crew training. 122.420 Section 122.420 Shipping COAST....420 Crew training. (a) The owner, charterer, master, or managing operator shall instruct each crew... § 122.514. (b) Training conducted on a sister vessel may be considered equivalent to the initial and...

19 CFR § 122.114 - Contents.

Code of Federal Regulations, 2010 CFR

2018-04-01

... 19 Customs Duties 1 2018-04-01 2018-04-01 false Contents. § 122.114 Section § 122.114 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY AIR COMMERCE REGULATIONS Transit Air Cargo Manifest (TACM) Procedures § 122.114 Contents. (a) Form...

19 CFR § 122.114 - Contents.

Code of Federal Regulations, 2010 CFR

2015-04-01

... 19 Customs Duties 1 2015-04-01 2015-04-01 false Contents. § 122.114 Section § 122.114 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY AIR COMMERCE REGULATIONS Transit Air Cargo Manifest (TACM) Procedures § 122.114 Contents. (a) Form...

Managing geological uncertainty in CO2-EOR reservoir assessments

NASA Astrophysics Data System (ADS)

Welkenhuysen, Kris; Piessens, Kris

2014-05-01

Recently the European Parliament has agreed that an atlas for the storage potential of CO2 is of high importance to have a successful commercial introduction of CCS (CO2 capture and geological storage) technology in Europe. CO2-enhanced oil recovery (CO2-EOR) is often proposed as a promising business case for CCS, and likely has a high potential in the North Sea region. Traditional economic assessments for CO2-EOR largely neglect the geological reality of reservoir uncertainties because these are difficult to introduce realistically in such calculations. There is indeed a gap between the outcome of a reservoir simulation and the input values for e.g. cost-benefit evaluations, especially where it concerns uncertainty. The approach outlined here is to turn the procedure around, and to start from which geological data is typically (or minimally) requested for an economic assessment. Thereafter it is evaluated how this data can realistically be provided by geologists and reservoir engineers. For the storage of CO2 these parameters are total and yearly CO2 injection capacity, and containment or potential on leakage. Specifically for the EOR operation, two additional parameters can be defined: the EOR ratio, or the ratio of recovered oil over injected CO2, and the CO2 recycling ratio of CO2 that is reproduced after breakthrough at the production well. A critical but typically estimated parameter for CO2-EOR projects is the EOR ratio, taken in this brief outline as an example. The EOR ratio depends mainly on local geology (e.g. injection per well), field design (e.g. number of wells), and time. Costs related to engineering can be estimated fairly good, given some uncertainty range. The problem is usually to reliably estimate the geological parameters that define the EOR ratio. Reliable data is only available from (onshore) CO2-EOR projects in the US. Published studies for the North Sea generally refer to these data in a simplified form, without uncertainty ranges, and are

45 CFR 400.113 - Duration of eligibility.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 2 2010-10-01 2010-10-01 false Duration of eligibility. 400.113 Section 400.113 Public Welfare Regulations Relating to Public Welfare OFFICE OF REFUGEE RESETTLEMENT, ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES REFUGEE RESETTLEMENT PROGRAM Child Welfare...

19 CFR 122.165 - Air cabotage.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 19 Customs Duties 1 2012-04-01 2012-04-01 false Air cabotage. 122.165 Section 122.165 Customs... AIR COMMERCE REGULATIONS Penalties § 122.165 Air cabotage. (a) The air cabotage law (49 U.S.C. 41703... of U.S. registration except those foreign-registered aircraft leased or chartered to a U.S. air...

19 CFR 122.165 - Air cabotage.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 19 Customs Duties 1 2013-04-01 2013-04-01 false Air cabotage. 122.165 Section 122.165 Customs... AIR COMMERCE REGULATIONS Penalties § 122.165 Air cabotage. (a) The air cabotage law (49 U.S.C. 41703... of U.S. registration except those foreign-registered aircraft leased or chartered to a U.S. air...

19 CFR 122.165 - Air cabotage.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 19 Customs Duties 1 2014-04-01 2014-04-01 false Air cabotage. 122.165 Section 122.165 Customs... AIR COMMERCE REGULATIONS Penalties § 122.165 Air cabotage. (a) The air cabotage law (49 U.S.C. 41703... of U.S. registration except those foreign-registered aircraft leased or chartered to a U.S. air...

19 CFR 122.165 - Air cabotage.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 19 Customs Duties 1 2010-04-01 2010-04-01 false Air cabotage. 122.165 Section 122.165 Customs... AIR COMMERCE REGULATIONS Penalties § 122.165 Air cabotage. (a) The air cabotage law (49 U.S.C. 41703... of U.S. registration except those foreign-registered aircraft leased or chartered to a U.S. air...

19 CFR 122.165 - Air cabotage.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 19 Customs Duties 1 2011-04-01 2011-04-01 false Air cabotage. 122.165 Section 122.165 Customs... AIR COMMERCE REGULATIONS Penalties § 122.165 Air cabotage. (a) The air cabotage law (49 U.S.C. 41703... of U.S. registration except those foreign-registered aircraft leased or chartered to a U.S. air...

36 CFR 228.113 - Notice of noncompliance.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Notice of noncompliance. 228.113 Section 228.113 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE.... When an authorized Forest officer finds that the operator is not in compliance with a reclamation or...

19 CFR § 122.114 - Contents.

Code of Federal Regulations, 2010 CFR

2008-04-01

... 19 Customs Duties 1 2008-04-01 2008-04-01 false Contents. § 122.114 Section § 122.114 Customs Duties BUREAU OF CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY AIR COMMERCE REGULATIONS Transit Air Cargo Manifest (TACM) Procedures § 122.114 Contents. (a) Form duplicates original manifest. Each transit...

46 CFR 122.503 - Voyage plan.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Voyage plan. 122.503 Section 122.503 Shipping COAST... Emergencies § 122.503 Voyage plan. (a) The master of the following vessels shall prepare a voyage plan: (1) A... United States Great Lakes port from a Canadian Great Lakes port. (b) The voyage plan required by...

Del(12)(p11.21p12.2) associated with an asphyxiating thoracic dystrophy or chondroectodermal dysplasia-like syndrome

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nagai, T.; Kato, R.; Hasegawa, T.

1995-01-02

We describe a 5-year-old Japanese boy who has some radiographic findings characteristic of asphyxiating thoracic dystrophy (ATD)-chondroectodermal dysplasia with a de novo chromosome abnormality. He also has mild mental retardation, short stature, hypoplastic hair and skin, oligodontia, small thoracic cage, hypoplastic pelvis and cone-shaped epiphyses of hands. On cytogenetic studies he was found to have a de novo del(12)(p11.21p12.2). These results suggest that the locus of the gene associated with ATD-chondroectodermal dysplasia may be situated at 12p11.21p12.2. 11 refs., 2 figs.

21 CFR 139.122 - Enriched nonfat milk macaroni products.

Code of Federal Regulations, 2013 CFR

2013-04-01

...) of this section), enriched farina, or enriched flour. They may be added in a harmless carrier, such... 21 Food and Drugs 2 2013-04-01 2013-04-01 false Enriched nonfat milk macaroni products. 139.122... Macaroni and Noodle Products § 139.122 Enriched nonfat milk macaroni products. (a) Each of the enriched...

21 CFR 139.122 - Enriched nonfat milk macaroni products.

Code of Federal Regulations, 2012 CFR

2012-04-01

...) of this section), enriched farina, or enriched flour. They may be added in a harmless carrier, such... 21 Food and Drugs 2 2012-04-01 2012-04-01 false Enriched nonfat milk macaroni products. 139.122... Macaroni and Noodle Products § 139.122 Enriched nonfat milk macaroni products. (a) Each of the enriched...

21 CFR 139.122 - Enriched nonfat milk macaroni products.

Code of Federal Regulations, 2014 CFR

2014-04-01

...) of this section), enriched farina, or enriched flour. They may be added in a harmless carrier, such... 21 Food and Drugs 2 2014-04-01 2014-04-01 false Enriched nonfat milk macaroni products. 139.122... Macaroni and Noodle Products § 139.122 Enriched nonfat milk macaroni products. (a) Each of the enriched...

10 CFR 51.122 - List of interested organizations and groups.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 2 2014-01-01 2014-01-01 false List of interested organizations and groups. 51.122 Section 51.122 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) ENVIRONMENTAL PROTECTION REGULATIONS FOR DOMESTIC LICENSING AND RELATED REGULATORY FUNCTIONS National Environmental Policy Act-Regulations...

10 CFR 51.122 - List of interested organizations and groups.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 2 2010-01-01 2010-01-01 false List of interested organizations and groups. 51.122 Section 51.122 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) ENVIRONMENTAL PROTECTION REGULATIONS FOR DOMESTIC LICENSING AND RELATED REGULATORY FUNCTIONS National Environmental Policy Act-Regulations...

40 CFR 86.113-04 - Fuel specifications.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Heavy-Duty Vehicles; Test Procedures § 86.113-04 Fuel specifications. This section includes text that... exhaust and evaporative emission testing: Table 1 of § 86.113-04—Test Fuel Specifications for Gasoline... method. (2) Manufacturers may use California test fuels, as follows: (i) For model year 2014 and earlier...

STS-122 Crew Return Ceremony

NASA Image and Video Library

2008-02-21

JSC2008-E-014907 (21 Feb. 2008) --- Johnson Space Center's (JSC) director Michael L. Coats (right) greets astronauts Rex Walheim (left) and Leland Melvin, STS-122 mission specialists, at Ellington Field near JSC prior to the STS-122 crew return ceremonies.

9 CFR 113.202 - Canine Hepatitis and Canine Adenovirus Type 2 Vaccine, Killed Virus.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Canine Hepatitis and Canine Adenovirus...; ORGANISMS AND VECTORS STANDARD REQUIREMENTS Killed Virus Vaccines § 113.202 Canine Hepatitis and Canine Adenovirus Type 2 Vaccine, Killed Virus. Canine Hepatitis and Canine Adenovirus Type 2 Vaccine, Killed Virus...

MicroRNA-122 regulates polyploidization in the murine liver.

PubMed

Hsu, Shu-Hao; Delgado, Evan R; Otero, P Anthony; Teng, Kun-Yu; Kutay, Huban; Meehan, Kolin M; Moroney, Justin B; Monga, Jappmann K; Hand, Nicholas J; Friedman, Joshua R; Ghoshal, Kalpana; Duncan, Andrew W

2016-08-01

A defining feature of the mammalian liver is polyploidy, a numerical change in the entire complement of chromosomes. The first step of polyploidization involves cell division with failed cytokinesis. Although polyploidy is common, affecting ∼90% of hepatocytes in mice and 50% in humans, the specialized role played by polyploid cells in liver homeostasis and disease remains poorly understood. The goal of this study was to identify novel signals that regulate polyploidization, and we focused on microRNAs (miRNAs). First, to test whether miRNAs could regulate hepatic polyploidy, we examined livers from Dicer1 liver-specific knockout mice, which are devoid of mature miRNAs. Loss of miRNAs resulted in a 3-fold reduction in binucleate hepatocytes, indicating that miRNAs regulate polyploidization. Second, we surveyed age-dependent expression of miRNAs in wild-type mice and identified a subset of miRNAs, including miR-122, that is differentially expressed at 2-3 weeks, a period when extensive polyploidization occurs. Next, we examined Mir122 knockout mice and observed profound, lifelong depletion of polyploid hepatocytes, proving that miR-122 is required for complete hepatic polyploidization. Moreover, the polyploidy defect in Mir122 knockout mice was ameliorated by adenovirus-mediated overexpression of miR-122, underscoring the critical role miR-122 plays in polyploidization. Finally, we identified direct targets of miR-122 (Cux1, Rhoa, Iqgap1, Mapre1, Nedd4l, and Slc25a34) that regulate cytokinesis. Inhibition of each target induced cytokinesis failure and promoted hepatic binucleation. Among the different signals that have been associated with hepatic polyploidy, miR-122 is the first liver-specific signal identified; our data demonstrate that miR-122 is both necessary and sufficient in liver polyploidization, and these studies will serve as the foundation for future work investigating miR-122 in liver maturation, homeostasis, and disease. (Hepatology 2016

MicroRNA-122 Regulates Polyploidization in the Murine Liver

PubMed Central

Hsu, Shu-hao; Delgado, Evan R.; Otero, P. Anthony; Teng, Kun-yu; Kutay, Huban; Meehan, Kolin M.; Moroney, Justin B.; Monga, Jappmann K.; Hand, Nicholas J.; Friedman, Joshua R.; Ghoshal, Kalpana; Duncan, Andrew W.

2016-01-01

A defining feature of the mammalian liver is polyploidy, a numerical change in the entire complement of chromosomes. The first step of polyploidization involves cell division with failed cytokinesis. Although polyploidy is common, affecting ~90% of hepatocytes in mice and 50% in humans, the specialized role played by polyploid cells in liver homeostasis and disease remains poorly understood. The goal of this study was to identify novel signals that regulate polyploidization, and we focused on microRNAs (miRNAs). First, to test whether miRNAs could regulate hepatic polyploidy we examined livers from Dicer1 liver-specific knockout mice, which are devoid of mature miRNAs. Loss of miRNAs resulted in a 3-fold reduction in binucleate hepatocytes, indicating that miRNAs regulate polyploidization. Secondly, we surveyed age-dependent expression of miRNAs in wild-type mice and identified a subset of miRNAs, including miR-122, that is differentially expressed at 2–3 weeks, a period when extensive polyploidization occurs. Next, we examined Mir122 knockout mice and observed profound, life-long depletion of polyploid hepatocytes, proving that miR-122 is required for complete hepatic polyploidization. Moreover, the polyploidy defect in Mir122 knockout mice was ameliorated by adenovirus-mediated over-expression of miR-122, underscoring the critical role miR-122 plays in polyploidization. Finally, we identified direct targets of miR-122 (Cux1, Rhoa, Iqgap1, Mapre1, Nedd4l and Slc25a34) that regulate cytokinesis. Inhibition of each target induced cytokinesis failure and promoted hepatic binucleation. Conclusion Our data demonstrate that miR-122 is both necessary and sufficient in liver polyploidization. Among the different signals that have been associated with hepatic polyploidy, miR-122 is the first liver-specific signal identified. These studies will serve as the foundation for future work investigating miR-122 in liver maturation, homeostasis and disease. PMID:27016325

Alagille syndrome with deletion 20p12.2-p12.3 and hypoplastic left heart.

PubMed

Robert, Marie Leema P; Lopez, Tony; Crolla, John; Huang, Shuwen; Owen, Carol; Burvill-Holmes, Lisa; Stumper, Oliver; Turnpenny, Peter D

2007-10-01

We report a male patient born at 37-weeks gestation, weighing 1.885 kg (<0.4th centile). Shortly after birth, he was diagnosed with hypoplastic left heart syndrome for which he underwent a Norwood procedure. Subsequently, he developed problems with failure to thrive and developmental delay. At the age of 4 years his delay in growth and development led to further investigations, which revealed a small de-novo interstitial deletion of chromosome 20p12.2. JAGGED1 haploinsufficiency was confirmed by fluorescence in situ hybridization. Array-comparative genomic hybridization analysis confirmed and quantified an approximate 5.4 Mb interstitial deletion involving the chromosomal region 20p12.2-p12.3. This precise interstitial deletion has not been previously reported. Further clinical evaluation revealed posterior embryotoxon and butterfly vertebrae. He has normal liver function tests, facial features consistent with Alagille syndrome, and mild learning difficulties. To our knowledge this is the first report of Alagille syndrome associated with hypoplastic left heart syndrome.

5 CFR 185.122 - Discovery.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Discovery. 185.122 Section 185.122 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PROGRAM FRAUD CIVIL REMEDIES..., answers, records, accounts, papers, and other data and documentary evidence. Nothing contained herein...

Geological factors affecting CO2 plume distribution

USGS Publications Warehouse

Frailey, S.M.; Leetaru, H.

2009-01-01

Understanding the lateral extent of a CO2 plume has important implications with regards to buying/leasing pore volume rights, defining the area of review for an injection permit, determining the extent of an MMV plan, and managing basin-scale sequestration from multiple injection sites. The vertical and lateral distribution of CO2 has implications with regards to estimating CO2 storage volume at a specific site and the pore pressure below the caprock. Geologic and flow characteristics such as effective permeability and porosity, capillary pressure, lateral and vertical permeability anisotropy, geologic structure, and thickness all influence and affect the plume distribution to varying degrees. Depending on the variations in these parameters one may dominate the shape and size of the plume. Additionally, these parameters do not necessarily act independently. A comparison of viscous and gravity forces will determine the degree of vertical and lateral flow. However, this is dependent on formation thickness. For example in a thick zone with injection near the base, the CO2 moves radially from the well but will slow at greater radii and vertical movement will dominate. Generally the CO2 plume will not appreciably move laterally until the caprock or a relatively low permeability interval is contacted by the CO2. Conversely, in a relatively thin zone with the injection interval over nearly the entire zone, near the wellbore the CO2 will be distributed over the entire vertical component and will move laterally much further with minimal vertical movement. Assuming no geologic structure, injecting into a thin zone or into a thick zone immediately under a caprock will result in a larger plume size. With a geologic structure such as an anticline, CO2 plume size may be restricted and injection immediately below the caprock may have less lateral plume growth because the structure will induce downward vertical movement of the CO2 until the outer edge of the plume reaches a spill

SUBSURFACE PROPERTY RIGHTS: IMPLICATIONS FOR GEOLOGIC CO2 SEQUESTRATION (PRESENTATION)

EPA Science Inventory

The paper discusses subsurface property rights as they apply to geologic sequestration (GS) of carbon dioxide (CO2). GS projects inject captured CO2 into deep (greater than ~1 km) geologic formations for the explicit purpose of avoiding atmospheric emission of CO2. Because of the...

10 CFR § 501.122 - Contents.

Code of Federal Regulations, 2010 CFR

2017-01-01

... 10 Energy 4 2017-01-01 2017-01-01 false Contents. § 501.122 Section § 501.122 Energy DEPARTMENT OF ENERGY (CONTINUED) ALTERNATE FUELS ADMINISTRATIVE PROCEDURES AND SANCTIONS Requests for Stay § 501.122 Contents. (a) A petition for a stay shall contain a full and complete statement of all facts believed to be pertinent to the act or transaction...

27 CFR 479.122 - Requirements.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 27 Alcohol, Tobacco Products and Firearms 3 2011-04-01 2010-04-01 true Requirements. 479.122 Section 479.122 Alcohol, Tobacco Products, and Firearms BUREAU OF ALCOHOL, TOBACCO, FIREARMS, AND EXPLOSIVES, DEPARTMENT OF JUSTICE FIREARMS AND AMMUNITION MACHINE GUNS, DESTRUCTIVE DEVICES, AND CERTAIN...

27 CFR 479.122 - Requirements.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 3 2010-04-01 2010-04-01 false Requirements. 479.122 Section 479.122 Alcohol, Tobacco Products, and Firearms BUREAU OF ALCOHOL, TOBACCO, FIREARMS, AND EXPLOSIVES, DEPARTMENT OF JUSTICE FIREARMS AND AMMUNITION MACHINE GUNS, DESTRUCTIVE DEVICES, AND CERTAIN...

27 CFR 479.122 - Requirements.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 27 Alcohol, Tobacco Products and Firearms 3 2012-04-01 2010-04-01 true Requirements. 479.122 Section 479.122 Alcohol, Tobacco Products, and Firearms BUREAU OF ALCOHOL, TOBACCO, FIREARMS, AND EXPLOSIVES, DEPARTMENT OF JUSTICE FIREARMS AND AMMUNITION MACHINE GUNS, DESTRUCTIVE DEVICES, AND CERTAIN...

27 CFR 479.122 - Requirements.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 27 Alcohol, Tobacco Products and Firearms 3 2013-04-01 2013-04-01 false Requirements. 479.122 Section 479.122 Alcohol, Tobacco Products, and Firearms BUREAU OF ALCOHOL, TOBACCO, FIREARMS, AND EXPLOSIVES, DEPARTMENT OF JUSTICE FIREARMS AND AMMUNITION MACHINE GUNS, DESTRUCTIVE DEVICES, AND CERTAIN...

27 CFR 479.122 - Requirements.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 27 Alcohol, Tobacco Products and Firearms 3 2014-04-01 2014-04-01 false Requirements. 479.122 Section 479.122 Alcohol, Tobacco Products, and Firearms BUREAU OF ALCOHOL, TOBACCO, FIREARMS, AND EXPLOSIVES, DEPARTMENT OF JUSTICE FIREARMS AND AMMUNITION MACHINE GUNS, DESTRUCTIVE DEVICES, AND CERTAIN...

7 CFR 959.122 - Application.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Application. 959.122 Section 959.122 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... transportation; the consignee; the destination; the purpose for which the onions are to be used; and...

7 CFR 945.122 - Application.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Application. 945.122 Section 945.122 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... of transportation; the consignee; the destination; the purpose for which the potatoes are to be used...

14 CFR 1260.122 - Payment.

Code of Federal Regulations, 2010 CFR

2010-01-01

... would not be feasible within the expected Federal and non-Federal cash resources. (l) Interest earned on..., Hospitals, and Other Non-Profit Organizations Post-Award Requirements § 1260.122 Payment. (a) Payment... that meet the standards for fund control and accountability as established in § 1260.121. (2) Cash...

7 CFR 948.122 - Application.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Application. 948.122 Section 948.122 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... destination; the purpose for which the potatoes are to be used; a certification to the United States...

7 CFR 946.122 - Reports.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Reports. 946.122 Section 946.122 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Certificate number (if such inspection is required by regulations in effect at the time of such shipment...

25 CFR 122.5 - Selection/nomination process for committee members.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Section 122.5 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES MANAGEMENT OF OSAGE JUDGMENT FUNDS FOR EDUCATION § 122.5 Selection/nomination process for committee members. (a... eligible to serve on the Osage Tribal Education Committee. (2) Nominees for committee membership shall...

29 CFR 570.122 - General.

Code of Federal Regulations, 2010 CFR

2010-07-01

... other than the following: (1) Manufacturing, (2) Mining, (3) An occupation found by the Secretary to be..., the revised text is set forth as follows: § 570.122 General. (a) Specific exemptions from the child... sixteen years in any occupation other than manufacturing, mining, or an occupation found by the Secretary...

40 CFR 405.113 - [Reserved

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 28 2010-07-01 2010-07-01 true [Reserved] 405.113 Section 405.113 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS DAIRY PRODUCTS PROCESSING POINT SOURCE CATEGORY Condensed Whey Subcategory § 405.113 [Reserved] ...

7 CFR 1220.113 - Marketing.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 10 2012-01-01 2012-01-01 false Marketing. 1220.113 Section 1220.113 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... CONSUMER INFORMATION Soybean Promotion and Research Order Definitions § 1220.113 Marketing. The term...

7 CFR 1220.113 - Marketing.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 10 2013-01-01 2013-01-01 false Marketing. 1220.113 Section 1220.113 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... CONSUMER INFORMATION Soybean Promotion and Research Order Definitions § 1220.113 Marketing. The term...

7 CFR 1220.113 - Marketing.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 10 2014-01-01 2014-01-01 false Marketing. 1220.113 Section 1220.113 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... CONSUMER INFORMATION Soybean Promotion and Research Order Definitions § 1220.113 Marketing. The term...

7 CFR 1220.113 - Marketing.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 10 2011-01-01 2011-01-01 false Marketing. 1220.113 Section 1220.113 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... CONSUMER INFORMATION Soybean Promotion and Research Order Definitions § 1220.113 Marketing. The term...

32 CFR 724.113 - Application.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 5 2010-07-01 2010-07-01 false Application. 724.113 Section 724.113 National... Definitions § 724.113 Application. In the context of this Manual, a written application to the NDRB for the... must be used for the application. ...

40 CFR 122.47 - Schedules of compliance.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 21 2010-07-01 2010-07-01 false Schedules of compliance. 122.47 Section 122.47 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS EPA ADMINISTERED PERMIT PROGRAMS: THE NATIONAL POLLUTANT DISCHARGE ELIMINATION SYSTEM Permit Conditions § 122.47...

40 CFR 122.47 - Schedules of compliance.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 22 2011-07-01 2011-07-01 false Schedules of compliance. 122.47 Section 122.47 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS EPA ADMINISTERED PERMIT PROGRAMS: THE NATIONAL POLLUTANT DISCHARGE ELIMINATION SYSTEM Permit Conditions § 122.47...

A 1,681-locus consensus genetic map of cultivated cucumber including 67 NB-LRR resistance gene homolog and ten gene loci

PubMed Central

2013-01-01

Background Cucumber is an important vegetable crop that is susceptible to many pathogens, but no disease resistance (R) genes have been cloned. The availability of whole genome sequences provides an excellent opportunity for systematic identification and characterization of the nucleotide binding and leucine-rich repeat (NB-LRR) type R gene homolog (RGH) sequences in the genome. Cucumber has a very narrow genetic base making it difficult to construct high-density genetic maps. Development of a consensus map by synthesizing information from multiple segregating populations is a method of choice to increase marker density. As such, the objectives of the present study were to identify and characterize NB-LRR type RGHs, and to develop a high-density, integrated cucumber genetic-physical map anchored with RGH loci. Results From the Gy14 draft genome, 70 NB-containing RGHs were identified and characterized. Most RGHs were in clusters with uneven distribution across seven chromosomes. In silico analysis indicated that all 70 RGHs had EST support for gene expression. Phylogenetic analysis classified 58 RGHs into two clades: CNL and TNL. Comparative analysis revealed high-degree sequence homology and synteny in chromosomal locations of these RGH members between the cucumber and melon genomes. Fifty-four molecular markers were developed to delimit 67 of the 70 RGHs, which were integrated into a genetic map through linkage analysis. A 1,681-locus cucumber consensus map including 10 gene loci and spanning 730.0 cM in seven linkage groups was developed by integrating three component maps with a bin-mapping strategy. Physically, 308 scaffolds with 193.2 Mbp total DNA sequences were anchored onto this consensus map that covered 52.6% of the 367 Mbp cucumber genome. Conclusions Cucumber contains relatively few NB-LRR RGHs that are clustered and unevenly distributed in the genome. All RGHs seem to be transcribed and shared significant sequence homology and synteny with the melon

Elevating microRNA-122 in blood improves outcomes after temporary middle cerebral artery occlusion in rats

PubMed Central

Jickling, Glen C; Ander, Bradley P; Hull, Heather; Zhan, Xinhua; Cox, Christopher; Shroff, Natasha; Dykstra-Aiello, Cheryl; Stamova, Boryana; Sharp, Frank R

2015-01-01

Because our recent studies have demonstrated that miR-122 decreased in whole blood of patients and in whole blood of rats following ischemic stroke, we tested whether elevating blood miR-122 would improve stroke outcomes in rats. Young adult rats were subjected to a temporary middle cerebral artery occlusion (MCAO) or sham operation. A polyethylene glycol-liposome-based transfection system was used to administer a miR-122 mimic after MCAO. Neurological deficits, brain infarction, brain vessel integrity, adhesion molecule expression and expression of miR-122 target and indirect-target genes were examined in blood at 24 h after MCAO with or without miR-122 treatment. miR-122 decreased in blood after MCAO, whereas miR-122 mimic elevated miR-122 in blood 24 h after MCAO. Intravenous but not intracerebroventricular injection of miR-122 mimic decreased neurological deficits and brain infarction, attenuated ICAM-1 expression, and maintained vessel integrity after MCAO. The miR-122 mimic also down-regulated direct target genes (e.g. Vcam1, Nos2, Pla2g2a) and indirect target genes (e.g. Alox5, Itga2b, Timp3, Il1b, Il2, Mmp8) in blood after MCAO which are predicted to affect cell adhesion, diapedesis, leukocyte extravasation, eicosanoid and atherosclerosis signaling. The data show that elevating miR-122 improves stroke outcomes and we postulate this occurs via downregulating miR-122 target genes in blood leukocytes. PMID:26661204

40 CFR 113.1 - Purpose.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 22 2014-07-01 2013-07-01 true Purpose. 113.1 Section 113.1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS LIABILITY LIMITS FOR SMALL ONSHORE STORAGE FACILITIES Oil Storage Facilities § 113.1 Purpose. This subpart establishes size...

40 CFR 113.1 - Purpose.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 23 2012-07-01 2012-07-01 false Purpose. 113.1 Section 113.1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS LIABILITY LIMITS FOR SMALL ONSHORE STORAGE FACILITIES Oil Storage Facilities § 113.1 Purpose. This subpart establishes size...

42 CFR 66.113 - Publications.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 1 2011-10-01 2011-10-01 false Publications. 66.113 Section 66.113 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING NATIONAL RESEARCH SERVICE AWARDS Direct Awards § 66.113 Publications. Publication, distribution, and...

42 CFR 66.113 - Publications.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 1 2012-10-01 2012-10-01 false Publications. 66.113 Section 66.113 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING NATIONAL RESEARCH SERVICE AWARDS Direct Awards § 66.113 Publications. Publication, distribution, and...

42 CFR 66.113 - Publications.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Publications. 66.113 Section 66.113 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING NATIONAL RESEARCH SERVICE AWARDS Direct Awards § 66.113 Publications. Publication, distribution, and...

42 CFR 66.113 - Publications.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 1 2014-10-01 2014-10-01 false Publications. 66.113 Section 66.113 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING NATIONAL RESEARCH SERVICE AWARDS Direct Awards § 66.113 Publications. Publication, distribution, and...

42 CFR 66.113 - Publications.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 1 2013-10-01 2013-10-01 false Publications. 66.113 Section 66.113 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING NATIONAL RESEARCH SERVICE AWARDS Direct Awards § 66.113 Publications. Publication, distribution, and...

17 CFR 200.113 - Opportunity to respond; interception.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 17 Commodity and Securities Exchanges 2 2012-04-01 2012-04-01 false Opportunity to respond; interception. 200.113 Section 200.113 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION ORGANIZATION; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Code of Behavior Governing Ex Parte...

17 CFR 200.113 - Opportunity to respond; interception.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 17 Commodity and Securities Exchanges 2 2013-04-01 2013-04-01 false Opportunity to respond; interception. 200.113 Section 200.113 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION ORGANIZATION; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Code of Behavior Governing Ex Parte...

17 CFR 200.113 - Opportunity to respond; interception.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 17 Commodity and Securities Exchanges 2 2011-04-01 2011-04-01 false Opportunity to respond; interception. 200.113 Section 200.113 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION ORGANIZATION; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Code of Behavior Governing Ex Parte...

17 CFR 200.113 - Opportunity to respond; interception.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Opportunity to respond; interception. 200.113 Section 200.113 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION ORGANIZATION; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Code of Behavior Governing Ex Parte...

13 CFR 113.510 - Recruitment.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 13 Business Credit and Assistance 1 2013-01-01 2013-01-01 false Recruitment. 113.510 Section 113.510 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION NONDISCRIMINATION IN FINANCIAL... Discrimination on the Basis of Sex in Employment in Education Programs Or Activities Prohibited § 113.510...

40 CFR 113.3 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 23 2012-07-01 2012-07-01 false Definitions. 113.3 Section 113.3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS LIABILITY LIMITS FOR SMALL ONSHORE STORAGE FACILITIES Oil Storage Facilities § 113.3 Definitions. As used in this subpart...

40 CFR 113.5 - Exclusions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 22 2014-07-01 2013-07-01 true Exclusions. 113.5 Section 113.5 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS LIABILITY LIMITS FOR SMALL ONSHORE STORAGE FACILITIES Oil Storage Facilities § 113.5 Exclusions. This subpart does not apply...

40 CFR 113.3 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 22 2014-07-01 2013-07-01 true Definitions. 113.3 Section 113.3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS LIABILITY LIMITS FOR SMALL ONSHORE STORAGE FACILITIES Oil Storage Facilities § 113.3 Definitions. As used in this subpart...

40 CFR 113.5 - Exclusions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 23 2012-07-01 2012-07-01 false Exclusions. 113.5 Section 113.5 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS LIABILITY LIMITS FOR SMALL ONSHORE STORAGE FACILITIES Oil Storage Facilities § 113.5 Exclusions. This subpart does not apply...

MD-2 residues tyrosine 42, arginine 69, aspartic acid 122, and leucine 125 provide species specificity for lipid IVA.

PubMed

Meng, Jianmin; Drolet, Joshua R; Monks, Brian G; Golenbock, Douglas T

2010-09-03

Lipopolysaccharide (LPS) activates the innate immune response through the Toll-like receptor 4 (TLR4).MD-2 complex. A synthetic lipid A precursor, lipid IV(A), induces an innate immune response in mice but not in humans. Both TLR4 and MD-2 are required for the agonist activity of lipid IV(A) in mice, with TLR4 interacting through specific surface charges at the dimerization interface. In this study, we used site-directed mutagenesis to identify the MD-2 residues that determine lipid IV(A) species specificity. A single mutation of murine MD-2 at the hydrophobic pocket entrance, E122K, substantially reduced the response to lipid IV(A). Combining the murine MD-2 E122K with the murine TLR4 K367E/S386K/R434Q mutations completely abolished the response to lipid IV(A), effectively converting the murine cellular response to a human-like response. In human cells, however, simultaneous mutations of K122E, K125L, Y41F, and R69G on human MD-2 were required to promote a response to lipid IV(A). Combining the human MD-2 quadruple mutations with the human TLR4 E369K/Q436R mutations completely converted the human MD-2/human TLR4 receptor to a murine-like receptor. Because MD-2 residues 122 and 125 reside at the dimerization interface near the pocket entrance, surface charge differences here directly affect receptor dimerization. In comparison, residues 42 and 69 reside at the MD-2/TLR4 interaction surface opposite the dimerization interface. Surface charge differences there likely affect the binding angle and/or rigidity between MD-2 and TLR4, exerting an indirect influence on receptor dimerization and activation. Thus, surface charge differences at the two MD-2/TLR4 interfaces determine the species-specific activation of lipid IV(A).

22 CFR 41.122 - Revocation of visas.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Revocation of visas. 41.122 Section 41.122 Foreign Relations DEPARTMENT OF STATE VISAS VISAS: DOCUMENTATION OF NONIMMIGRANTS UNDER THE IMMIGRATION AND NATIONALITY ACT, AS AMENDED Refusals and Revocations § 41.122 Revocation of visas. (a) Grounds for...

22 CFR 41.122 - Revocation of visas.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Revocation of visas. 41.122 Section 41.122 Foreign Relations DEPARTMENT OF STATE VISAS VISAS: DOCUMENTATION OF NONIMMIGRANTS UNDER THE IMMIGRATION AND NATIONALITY ACT, AS AMENDED Refusals and Revocations § 41.122 Revocation of visas. (a) Grounds for...

22 CFR 41.122 - Revocation of visas.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Revocation of visas. 41.122 Section 41.122 Foreign Relations DEPARTMENT OF STATE VISAS VISAS: DOCUMENTATION OF NONIMMIGRANTS UNDER THE IMMIGRATION AND NATIONALITY ACT, AS AMENDED Refusals and Revocations § 41.122 Revocation of visas. (a) Grounds for...

22 CFR 41.122 - Revocation of visas.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Revocation of visas. 41.122 Section 41.122 Foreign Relations DEPARTMENT OF STATE VISAS VISAS: DOCUMENTATION OF NONIMMIGRANTS UNDER THE IMMIGRATION AND NATIONALITY ACT, AS AMENDED Refusals and Revocations § 41.122 Revocation of visas. (a) Grounds for...

22 CFR 41.122 - Revocation of visas.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Revocation of visas. 41.122 Section 41.122 Foreign Relations DEPARTMENT OF STATE VISAS VISAS: DOCUMENTATION OF NONIMMIGRANTS UNDER THE IMMIGRATION AND NATIONALITY ACT, AS AMENDED Refusals and Revocations § 41.122 Revocation of visas. (a) Grounds for...

46 CFR 122.208 - Accidents to machinery.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Accidents to machinery. 122.208 Section 122.208 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS CARRYING MORE THAN 150... Voyage Records § 122.208 Accidents to machinery. The owner, managing operator, or master shall report...

46 CFR 122.208 - Accidents to machinery.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 4 2011-10-01 2011-10-01 false Accidents to machinery. 122.208 Section 122.208 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS CARRYING MORE THAN 150... Voyage Records § 122.208 Accidents to machinery. The owner, managing operator, or master shall report...

29 CFR 1910.122 - Table of contents.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 29 Labor 5 2012-07-01 2012-07-01 false Table of contents. 1910.122 Section 1910.122 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR OCCUPATIONAL SAFETY AND HEALTH STANDARDS Hazardous Materials Dipping and Coating Operations § 1910.122 Table of...

19 CFR 122.175 - Exemption from penalties.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 19 Customs Duties 1 2010-04-01 2010-04-01 false Exemption from penalties. 122.175 Section 122.175 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY AIR COMMERCE REGULATIONS Air Carrier Smuggling Prevention Program § 122.175 Exemption from...

46 CFR 56.01-3 - Power boilers, external piping and appurtenances (Replaces 100.1.1, 100.1.2, 122.1, 132 and 133).

Code of Federal Regulations, 2011 CFR

2011-10-01

... (Replaces 100.1.1, 100.1.2, 122.1, 132 and 133). 56.01-3 Section 56.01-3 Shipping COAST GUARD, DEPARTMENT OF... boilers, external piping and appurtenances (Replaces 100.1.1, 100.1.2, 122.1, 132 and 133). (a) Power... appurtenances of power boilers, as defined in §§ 100.1.1 and 100.1.2, appearing in the various paragraphs of...

46 CFR 56.01-3 - Power boilers, external piping and appurtenances (Replaces 100.1.1, 100.1.2, 122.1, 132 and 133).

Code of Federal Regulations, 2010 CFR

2010-10-01

... (Replaces 100.1.1, 100.1.2, 122.1, 132 and 133). 56.01-3 Section 56.01-3 Shipping COAST GUARD, DEPARTMENT OF... boilers, external piping and appurtenances (Replaces 100.1.1, 100.1.2, 122.1, 132 and 133). (a) Power... appurtenances of power boilers, as defined in §§ 100.1.1 and 100.1.2, appearing in the various paragraphs of...

50 CFR 14.122 - Food and water.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 1 2014-10-01 2014-10-01 false Food and water. 14.122 Section 14.122... Wild Mammals and Birds to the United States Specifications for Nonhuman Primates § 14.122 Food and... shall provide suitable food to any nonhuman primate at least once every 12 hours. ...

50 CFR 14.122 - Food and water.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 1 2012-10-01 2012-10-01 false Food and water. 14.122 Section 14.122... Wild Mammals and Birds to the United States Specifications for Nonhuman Primates § 14.122 Food and... shall provide suitable food to any nonhuman primate at least once every 12 hours. ...

50 CFR 14.122 - Food and water.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 1 2013-10-01 2013-10-01 false Food and water. 14.122 Section 14.122... Wild Mammals and Birds to the United States Specifications for Nonhuman Primates § 14.122 Food and... shall provide suitable food to any nonhuman primate at least once every 12 hours. ...

19 CFR 122.48 - Air cargo manifest.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 19 Customs Duties 1 2012-04-01 2012-04-01 false Air cargo manifest. 122.48 Section 122.48 Customs... AIR COMMERCE REGULATIONS Aircraft Entry and Entry Documents; Electronic Manifest Requirements for..., and Overflying the United States § 122.48 Air cargo manifest. (a) When required. Except as provided in...

19 CFR 122.48 - Air cargo manifest.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 19 Customs Duties 1 2013-04-01 2013-04-01 false Air cargo manifest. 122.48 Section 122.48 Customs... AIR COMMERCE REGULATIONS Aircraft Entry and Entry Documents; Electronic Manifest Requirements for..., and Overflying the United States § 122.48 Air cargo manifest. (a) When required. Except as provided in...

19 CFR 122.48 - Air cargo manifest.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 19 Customs Duties 1 2010-04-01 2010-04-01 false Air cargo manifest. 122.48 Section 122.48 Customs... AIR COMMERCE REGULATIONS Aircraft Entry and Entry Documents; Electronic Manifest Requirements for..., and Overflying the United States § 122.48 Air cargo manifest. (a) When required. Except as provided in...

19 CFR 122.48 - Air cargo manifest.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 19 Customs Duties 1 2011-04-01 2011-04-01 false Air cargo manifest. 122.48 Section 122.48 Customs... AIR COMMERCE REGULATIONS Aircraft Entry and Entry Documents; Electronic Manifest Requirements for..., and Overflying the United States § 122.48 Air cargo manifest. (a) When required. Except as provided in...

19 CFR 122.137 - Certificate of use.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 19 Customs Duties 1 2014-04-01 2014-04-01 false Certificate of use. 122.137 Section 122.137 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY AIR COMMERCE REGULATIONS Aircraft Liquor Kits § 122.137 Certificate of use. Any liquor or tobacco...

19 CFR 122.137 - Certificate of use.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 19 Customs Duties 1 2013-04-01 2013-04-01 false Certificate of use. 122.137 Section 122.137 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY AIR COMMERCE REGULATIONS Aircraft Liquor Kits § 122.137 Certificate of use. Any liquor or tobacco...

19 CFR 122.137 - Certificate of use.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 19 Customs Duties 1 2011-04-01 2011-04-01 false Certificate of use. 122.137 Section 122.137 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY AIR COMMERCE REGULATIONS Aircraft Liquor Kits § 122.137 Certificate of use. Any liquor or tobacco...

19 CFR 122.137 - Certificate of use.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 19 Customs Duties 1 2012-04-01 2012-04-01 false Certificate of use. 122.137 Section 122.137 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY AIR COMMERCE REGULATIONS Aircraft Liquor Kits § 122.137 Certificate of use. Any liquor or tobacco...

19 CFR 122.137 - Certificate of use.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 19 Customs Duties 1 2010-04-01 2010-04-01 false Certificate of use. 122.137 Section 122.137 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY AIR COMMERCE REGULATIONS Aircraft Liquor Kits § 122.137 Certificate of use. Any liquor or tobacco...

19 CFR 122.65 - Failure to depart.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 19 Customs Duties 1 2011-04-01 2011-04-01 false Failure to depart. 122.65 Section 122.65 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY AIR COMMERCE REGULATIONS Clearance of Aircraft and Permission To Depart § 122.65 Failure to depart...

19 CFR 122.65 - Failure to depart.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 19 Customs Duties 1 2013-04-01 2013-04-01 false Failure to depart. 122.65 Section 122.65 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY AIR COMMERCE REGULATIONS Clearance of Aircraft and Permission To Depart § 122.65 Failure to depart...

19 CFR 122.65 - Failure to depart.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 19 Customs Duties 1 2014-04-01 2014-04-01 false Failure to depart. 122.65 Section 122.65 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY AIR COMMERCE REGULATIONS Clearance of Aircraft and Permission To Depart § 122.65 Failure to depart...

19 CFR 122.65 - Failure to depart.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 19 Customs Duties 1 2010-04-01 2010-04-01 false Failure to depart. 122.65 Section 122.65 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY AIR COMMERCE REGULATIONS Clearance of Aircraft and Permission To Depart § 122.65 Failure to depart...

46 CFR 122.516 - Life jacket placards.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Life jacket placards. 122.516 Section 122.516 Shipping... Emergencies § 122.516 Life jacket placards. (a) Placards containing instructions for the donning and use of the life jackets aboard the vessel must be posted in conspicuous places that are regularly accessible...

46 CFR 122.516 - Life jacket placards.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 4 2011-10-01 2011-10-01 false Life jacket placards. 122.516 Section 122.516 Shipping... Emergencies § 122.516 Life jacket placards. (a) Placards containing instructions for the donning and use of the life jackets aboard the vessel must be posted in conspicuous places that are regularly accessible...

19 CFR 122.14 - Landing rights airport.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 19 Customs Duties 1 2010-04-01 2010-04-01 false Landing rights airport. 122.14 Section 122.14... TREASURY AIR COMMERCE REGULATIONS Classes of Airports § 122.14 Landing rights airport. (a) Permission to land. Permission to land at a landing rights airport may be given as follows: (1) Scheduled flight. The...

19 CFR 122.14 - Landing rights airport.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 19 Customs Duties 1 2011-04-01 2011-04-01 false Landing rights airport. 122.14 Section 122.14... TREASURY AIR COMMERCE REGULATIONS Classes of Airports § 122.14 Landing rights airport. (a) Permission to land. Permission to land at a landing rights airport may be given as follows: (1) Scheduled flight. The...

46 CFR 122.516 - Life jacket placards.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 4 2012-10-01 2012-10-01 false Life jacket placards. 122.516 Section 122.516 Shipping... Emergencies § 122.516 Life jacket placards. (a) Placards containing instructions for the donning and use of the life jackets aboard the vessel must be posted in conspicuous places that are regularly accessible...

46 CFR 122.516 - Life jacket placards.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 4 2014-10-01 2014-10-01 false Life jacket placards. 122.516 Section 122.516 Shipping... Emergencies § 122.516 Life jacket placards. (a) Placards containing instructions for the donning and use of the life jackets aboard the vessel must be posted in conspicuous places that are regularly accessible...

46 CFR 122.516 - Life jacket placards.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 4 2013-10-01 2013-10-01 false Life jacket placards. 122.516 Section 122.516 Shipping... Emergencies § 122.516 Life jacket placards. (a) Placards containing instructions for the donning and use of the life jackets aboard the vessel must be posted in conspicuous places that are regularly accessible...

19 CFR 122.4 - English language required.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 19 Customs Duties 1 2011-04-01 2011-04-01 false English language required. 122.4 Section 122.4... TREASURY AIR COMMERCE REGULATIONS General Definitions and Provisions § 122.4 English language required. A translation in the English language shall be attached to the original and each copy of any form or document...

19 CFR 122.4 - English language required.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 19 Customs Duties 1 2010-04-01 2010-04-01 false English language required. 122.4 Section 122.4... TREASURY AIR COMMERCE REGULATIONS General Definitions and Provisions § 122.4 English language required. A translation in the English language shall be attached to the original and each copy of any form or document...

19 CFR 122.14 - Landing rights airport.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 19 Customs Duties 1 2012-04-01 2012-04-01 false Landing rights airport. 122.14 Section 122.14... TREASURY AIR COMMERCE REGULATIONS Classes of Airports § 122.14 Landing rights airport. (a) Permission to land. Permission to land at a landing rights airport may be given as follows: (1) Scheduled flight. The...

19 CFR 122.14 - Landing rights airport.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 19 Customs Duties 1 2013-04-01 2013-04-01 false Landing rights airport. 122.14 Section 122.14... TREASURY AIR COMMERCE REGULATIONS Classes of Airports § 122.14 Landing rights airport. (a) Permission to land. Permission to land at a landing rights airport may be given as follows: (1) Scheduled flight. The...

19 CFR 122.14 - Landing rights airport.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 19 Customs Duties 1 2014-04-01 2014-04-01 false Landing rights airport. 122.14 Section 122.14... TREASURY AIR COMMERCE REGULATIONS Classes of Airports § 122.14 Landing rights airport. (a) Permission to land. Permission to land at a landing rights airport may be given as follows: (1) Scheduled flight. The...

Geological Structures Mapping of Bukit Bunuh using 2-D Resistivity Imaging Method

NASA Astrophysics Data System (ADS)

Nur Amalina, M. K. A.; Nordiana, M. M.; Rahman, Nazrin; Saidin, Mokhtar; Masnan, S. S. K.

2018-04-01

The geological area of Bukit Bunuh is very complex due to the meteorite impact that has occurred millions years ago at Lenggong, Perak. The lithology of the study area consists of alluvium, tephra dust, and granitic rock. The geological contact, fault and fracture zone were found at the study area may indicate the geological process that undergoes at a place locally or regionally. These important features have led to the further research on 2-D resistivity imaging method (2-D RIM) to study the geological features. This method can provide the subsurface image that will delineate the geological structures. The surveys include three separate lines of different length which depend on the accessibility. The surveys were done by using Pole-Dipole array and 10 m of electrodes spacing. The objectives of this research are to determine the subsurface geological contact and to determine the existence of fault/fracture zones at the contact zone. The results from 2-D inversion profiles have successfully signified the types of geological structural such as fault, contact, and fractures. Hence, the results from 2-D RIM were used to draw the geological lineaments of Bukit Bunuh. The discontinuity of the lineaments may indicate the structures present.

21 CFR 113.5 - Current good manufacturing practice.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Current good manufacturing practice. 113.5 Section 113.5 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION THERMALLY PROCESSED LOW-ACID FOODS PACKAGED IN HERMETICALLY SEALED...

21 CFR 113.5 - Current good manufacturing practice.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 2 2013-04-01 2013-04-01 false Current good manufacturing practice. 113.5 Section 113.5 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION THERMALLY PROCESSED LOW-ACID FOODS PACKAGED IN HERMETICALLY SEALED...

21 CFR 113.5 - Current good manufacturing practice.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 2 2012-04-01 2012-04-01 false Current good manufacturing practice. 113.5 Section 113.5 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION THERMALLY PROCESSED LOW-ACID FOODS PACKAGED IN HERMETICALLY SEALED...

21 CFR 113.5 - Current good manufacturing practice.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 2 2014-04-01 2014-04-01 false Current good manufacturing practice. 113.5 Section 113.5 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION THERMALLY PROCESSED LOW-ACID FOODS PACKAGED IN HERMETICALLY SEALED...

STS-113 crew during M-113 armored personnel carrier training

NASA Technical Reports Server (NTRS)

2002-01-01

KENNEDY SPACE CENTER, FLA. - STS-113 Mission Commander James Wetherbee gets ready to drive an M-113 armored personnel carrier, part of emergency egress training during Terminal Countdown Demonstration Test activities. He and the rest of the crew are preparing for the mission aboard Space Shuttle Endeavour, which is scheduled to launch Nov. 10. The TCDT includes a launch countdown. The primary payloads on mission STS-113 are the first port truss segment, P1, and the Crew and Equipment Translation Aid (CETA) Cart B. Once delivered, the P1 truss will remain stowed until flight 12A.1 in 2003 when it will be attached to the central truss segment, S0, on the Space Station. Also onboard Space Shuttle Endeavour will be the Expedition 6 crew who will replace Expedition 5, returning to Earth after 4 months.

STS-113 crew during M-113 armored personnel carrier training

NASA Technical Reports Server (NTRS)

2002-01-01

KENNEDY SPACE CENTER, FLA. -- STS-113 Mission Commander James Wetherbee practices driving an M-113 armored personnel carrier, part of emergency egress training during Terminal Countdown Demonstration Test activities. He and the rest of the crew are preparing for the mission aboard Space Shuttle Endeavour, which is scheduled to launch Nov. 10. The TCDT includes a launch countdown. The primary payloads on mission STS-113 are the first port truss segment, P1, and the Crew and Equipment Translation Aid (CETA) Cart B. Once delivered, the P1 truss will remain stowed until flight 12A.1 in 2003 when it will be attached to the central truss segment, S0, on the Space Station. Also onboard Space Shuttle Endeavour will be the Expedition 6 crew who will replace Expedition 5, returning to Earth after 4 months.

STS-113 crew during M-113 armored personnel carrier training

NASA Technical Reports Server (NTRS)

2002-01-01

KENNEDY SPACE CENTER, FLA. -- STS-113 Pilot Paul Lockhart stands inside an M-113 armored personnel carrier he is about to drive, part of emergency egress training during Terminal Countdown Demonstration Test activities. He and the rest of the crew are preparing for the mission aboard Space Shuttle Endeavour, which is scheduled to launch Nov. 10. The TCDT includes a simulated launch countdown. The primary payloads on mission STS-113 are the first port truss segment, P1, and the Crew and Equipment Translation Aid (CETA) Cart B. Once delivered, the P1 truss will remain stowed until flight 12A.1 in 2003 when it will be attached to the central truss segment, S0, on the Space Station. Also onboard Space Shuttle Endeavour will be the Expedition 6 crew who will replace Expedition 5, returning to Earth after 4 months.

19 CFR 122.27 - Documents required.

Code of Federal Regulations, 2012 CFR

2012-04-01

.../license, certificate of registration—(1) Pilot certificate/license. A commander of a private aircraft... officer. (2) Certificate of registration. A valid certificate of registration for private aircraft which... AIR COMMERCE REGULATIONS Private Aircraft § 122.27 Documents required. (a) Crewmembers and passengers...

19 CFR 122.27 - Documents required.

Code of Federal Regulations, 2013 CFR

2013-04-01

.../license, certificate of registration—(1) Pilot certificate/license. A commander of a private aircraft... officer. (2) Certificate of registration. A valid certificate of registration for private aircraft which... AIR COMMERCE REGULATIONS Private Aircraft § 122.27 Documents required. (a) Crewmembers and passengers...

19 CFR 122.27 - Documents required.

Code of Federal Regulations, 2014 CFR

2014-04-01

.../license, certificate of registration—(1) Pilot certificate/license. A commander of a private aircraft... officer. (2) Certificate of registration. A valid certificate of registration for private aircraft which... AIR COMMERCE REGULATIONS Private Aircraft § 122.27 Documents required. (a) Crewmembers and passengers...

19 CFR 122.27 - Documents required.

Code of Federal Regulations, 2010 CFR

2010-04-01

.../license, certificate of registration—(1) Pilot certificate/license. A commander of a private aircraft... officer. (2) Certificate of registration. A valid certificate of registration for private aircraft which... AIR COMMERCE REGULATIONS Private Aircraft § 122.27 Documents required. (a) Crewmembers and passengers...

19 CFR 122.27 - Documents required.

Code of Federal Regulations, 2011 CFR

2011-04-01

.../license, certificate of registration—(1) Pilot certificate/license. A commander of a private aircraft... officer. (2) Certificate of registration. A valid certificate of registration for private aircraft which... AIR COMMERCE REGULATIONS Private Aircraft § 122.27 Documents required. (a) Crewmembers and passengers...

46 CFR 122.704 - Maintenance of falls.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Maintenance of falls. 122.704 Section 122.704 Shipping..., Maintenance, and Inspection of Lifesaving Equipment § 122.704 Maintenance of falls. (a) Each fall used in a... fall must be renewed when necessary due to deterioration or at internals of not more than 5 years...

46 CFR 122.704 - Maintenance of falls.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 4 2011-10-01 2011-10-01 false Maintenance of falls. 122.704 Section 122.704 Shipping..., Maintenance, and Inspection of Lifesaving Equipment § 122.704 Maintenance of falls. (a) Each fall used in a... fall must be renewed when necessary due to deterioration or at internals of not more than 5 years...

46 CFR 122.704 - Maintenance of falls.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 4 2014-10-01 2014-10-01 false Maintenance of falls. 122.704 Section 122.704 Shipping..., Maintenance, and Inspection of Lifesaving Equipment § 122.704 Maintenance of falls. (a) Each fall used in a... fall must be renewed when necessary due to deterioration or at internals of not more than 5 years...

46 CFR 122.704 - Maintenance of falls.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 4 2013-10-01 2013-10-01 false Maintenance of falls. 122.704 Section 122.704 Shipping..., Maintenance, and Inspection of Lifesaving Equipment § 122.704 Maintenance of falls. (a) Each fall used in a... fall must be renewed when necessary due to deterioration or at internals of not more than 5 years...

46 CFR 122.704 - Maintenance of falls.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 4 2012-10-01 2012-10-01 false Maintenance of falls. 122.704 Section 122.704 Shipping..., Maintenance, and Inspection of Lifesaving Equipment § 122.704 Maintenance of falls. (a) Each fall used in a... fall must be renewed when necessary due to deterioration or at internals of not more than 5 years...

23 CFR 660.113 - Construction.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 23 Highways 1 2010-04-01 2010-04-01 false Construction. 660.113 Section 660.113 Highways FEDERAL... (DIRECT FEDERAL) Forest Highways § 660.113 Construction. (a) No construction shall be undertaken on any FH... construction of FHs will be performed by the contract method, unless construction by the FHWA, the FS, or a...

23 CFR 660.113 - Construction.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 23 Highways 1 2014-04-01 2014-04-01 false Construction. 660.113 Section 660.113 Highways FEDERAL... (DIRECT FEDERAL) Forest Highways § 660.113 Construction. (a) No construction shall be undertaken on any FH... construction of FHs will be performed by the contract method, unless construction by the FHWA, the FS, or a...

23 CFR 660.113 - Construction.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 23 Highways 1 2012-04-01 2012-04-01 false Construction. 660.113 Section 660.113 Highways FEDERAL... (DIRECT FEDERAL) Forest Highways § 660.113 Construction. (a) No construction shall be undertaken on any FH... construction of FHs will be performed by the contract method, unless construction by the FHWA, the FS, or a...

23 CFR 660.113 - Construction.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 23 Highways 1 2013-04-01 2013-04-01 false Construction. 660.113 Section 660.113 Highways FEDERAL... (DIRECT FEDERAL) Forest Highways § 660.113 Construction. (a) No construction shall be undertaken on any FH... construction of FHs will be performed by the contract method, unless construction by the FHWA, the FS, or a...

23 CFR 660.113 - Construction.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 23 Highways 1 2011-04-01 2011-04-01 false Construction. 660.113 Section 660.113 Highways FEDERAL... (DIRECT FEDERAL) Forest Highways § 660.113 Construction. (a) No construction shall be undertaken on any FH... construction of FHs will be performed by the contract method, unless construction by the FHWA, the FS, or a...

Validation and Verification of the Correct Operation of the Thermo Fisher Scientific’s Genesys 10S spectrometer used in ANC122 and NF-ANC122

DOE Office of Scientific and Technical Information (OSTI.GOV)

Colletti, Lisa Michelle

2016-02-19

In December of 2015, the old qualified Prim UV-Vis instrument used in the ANC122 and NFANC122 procedures failed its monthly calibration check. Attempts to get the system to pass by cleaning flow cells, replacing the light bulb and realigning the light path failed to get sustained reproducible results from the system. As it could no longer pass QA/QC requirements the decision to take it out of service was made. To replace the system, a previously purchased Thermo Fisher Scientific UV-VIS spectrometer (model Genesys 10S; Serial #: 2L5R059137) was retrieved from storage. This report shows that the system is performing asmore » required and meeting all QC requirements listed in ANC122 and NF-ANC122« less

Fine mapping and identification of a novel locus qGL12.2 control grain length in wild rice (Oryza rufipogon Griff.).

PubMed

Qi, Lan; Ding, Yingbin; Zheng, Xiaoming; Xu, Rui; Zhang, Lizhen; Wang, Yanyan; Wang, Xiaoning; Zhang, Lifang; Cheng, Yunlian; Qiao, Weihua; Yang, Qingwen

2018-04-19

A wild rice QTL qGL12.2 for grain length was fine mapped to an 82-kb interval in chromosome 12 containing six candidate genes and none was reported previously. Grain length is an important trait for yield and commercial value in rice. Wild rice seeds have a very slender shape and have many desirable genes that have been lost in cultivated rice during domestication. In this study, we identified a quantitative trait locus, qGL12.2, which controls grain length in wild rice. First, a wild rice chromosome segment substitution line, CSSL41, was selected that has longer glume and grains than does the Oryza sativa indica cultivar, 9311. Next, an F 2 population was constructed from a cross between CSSL41 and 9311. Using the next-generation sequencing combined with bulked-segregant analysis and F 3 recombinants analysis, qGL12.2 was finally fine mapped to an 82-kb interval in chromosome 12. Six candidate genes were found, and no reported grain length genes were found in this interval. Using scanning electron microscopy, we found that CSSL41 cells are significantly longer than those of 9311, but there is no difference in cell widths. These data suggest that qGL12.2 is a novel gene that controls grain cell length in wild rice. Our study provides a new genetic resource for rice breeding and a starting point for functional characterization of the wild rice GL gene.

49 CFR 213.122 - Torch cut rail.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 4 2011-10-01 2011-10-01 false Torch cut rail. 213.122 Section 213.122..., DEPARTMENT OF TRANSPORTATION TRACK SAFETY STANDARDS Track Structure § 213.122 Torch cut rail. (a) Except as a temporary repair in emergency situations no rail having a torch cut end shall be used in Classes 3 through 5...

19 CFR 122.15 - User fee airports.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 19 Customs Duties 1 2010-04-01 2010-04-01 false User fee airports. 122.15 Section 122.15 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY AIR COMMERCE REGULATIONS Classes of Airports § 122.15 User fee airports. (a) Permission to land. The procedures for obtaining permission to land at...

19 CFR 122.15 - User fee airports.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 19 Customs Duties 1 2011-04-01 2011-04-01 false User fee airports. 122.15 Section 122.15 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY AIR COMMERCE REGULATIONS Classes of Airports § 122.15 User fee airports. (a) Permission to land. The procedures for obtaining permission to land at...

49 CFR 213.122 - Torch cut rail.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 4 2010-10-01 2010-10-01 false Torch cut rail. 213.122 Section 213.122..., DEPARTMENT OF TRANSPORTATION TRACK SAFETY STANDARDS Track Structure § 213.122 Torch cut rail. (a) Except as a temporary repair in emergency situations no rail having a torch cut end shall be used in Classes 3 through 5...

19 CFR 122.15 - User fee airports.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 19 Customs Duties 1 2014-04-01 2014-04-01 false User fee airports. 122.15 Section 122.15 Customs... AIR COMMERCE REGULATIONS Classes of Airports § 122.15 User fee airports. (a) Permission to land. The procedures for obtaining permission to land at a user fee airport are the same procedures as those set forth...

19 CFR 122.15 - User fee airports.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 19 Customs Duties 1 2012-04-01 2012-04-01 false User fee airports. 122.15 Section 122.15 Customs... AIR COMMERCE REGULATIONS Classes of Airports § 122.15 User fee airports. (a) Permission to land. The procedures for obtaining permission to land at a user fee airport are the same procedures as those set forth...

19 CFR 122.15 - User fee airports.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 19 Customs Duties 1 2013-04-01 2013-04-01 false User fee airports. 122.15 Section 122.15 Customs... AIR COMMERCE REGULATIONS Classes of Airports § 122.15 User fee airports. (a) Permission to land. The procedures for obtaining permission to land at a user fee airport are the same procedures as those set forth...

9 CFR 202.113 - Rule 13: Written hearing.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Rule 13: Written hearing. 202.113 Section 202.113 Animals and Animal Products GRAIN INSPECTION, PACKERS AND STOCKYARDS ADMINISTRATION... waiver of the right to file such evidence. (g) Extension of time for depositions. If any party timely...

9 CFR 202.113 - Rule 13: Written hearing.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 9 Animals and Animal Products 2 2014-01-01 2014-01-01 false Rule 13: Written hearing. 202.113 Section 202.113 Animals and Animal Products GRAIN INSPECTION, PACKERS AND STOCKYARDS ADMINISTRATION... waiver of the right to file such evidence. (g) Extension of time for depositions. If any party timely...

9 CFR 202.113 - Rule 13: Written hearing.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 9 Animals and Animal Products 2 2013-01-01 2013-01-01 false Rule 13: Written hearing. 202.113 Section 202.113 Animals and Animal Products GRAIN INSPECTION, PACKERS AND STOCKYARDS ADMINISTRATION... waiver of the right to file such evidence. (g) Extension of time for depositions. If any party timely...

9 CFR 202.113 - Rule 13: Written hearing.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Rule 13: Written hearing. 202.113 Section 202.113 Animals and Animal Products GRAIN INSPECTION, PACKERS AND STOCKYARDS ADMINISTRATION... waiver of the right to file such evidence. (g) Extension of time for depositions. If any party timely...

9 CFR 202.113 - Rule 13: Written hearing.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 9 Animals and Animal Products 2 2012-01-01 2012-01-01 false Rule 13: Written hearing. 202.113 Section 202.113 Animals and Animal Products GRAIN INSPECTION, PACKERS AND STOCKYARDS ADMINISTRATION... waiver of the right to file such evidence. (g) Extension of time for depositions. If any party timely...

Haploinsufficiency of CELF4 at 18q12.2 is associated with developmental and behavioral disorders, seizures, eye manifestations, and obesity

PubMed Central

Halgren, Christina; Bache, Iben; Bak, Mads; Myatt, Mikkel Wanting; Anderson, Claire Marie; Brøndum-Nielsen, Karen; Tommerup, Niels

2012-01-01

Only 20 patients with deletions of 18q12.2 have been reported in the literature and the associated phenotype includes borderline intellectual disability, behavioral problems, seizures, obesity, and eye manifestations. Here, we report a male patient with a de novo translocation involving chromosomes 12 and 18, with borderline IQ, developmental and behavioral disorders, myopia, obesity, and febrile seizures in childhood. We characterized the rearrangement with Affymetrix SNP 6.0 Array analysis and next-generation mate pair sequencing and found truncation of CELF4 at 18q12.2. This second report of a patient with a neurodevelopmental phenotype and a translocation involving CELF4 supports that CELF4 is responsible for the phenotype associated with deletion of 18q12.2. Our study illustrates the utility of high-resolution genome-wide techniques in identifying neurodevelopmental and neurobehavioral genes, and it adds to the growing evidence, including a transgenic mouse model, that CELF4 is important for human brain development. PMID:22617346

21 CFR 11.3 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 1 2012-04-01 2012-04-01 false Definitions. 11.3 Section 11.3 Food and Drugs FOOD...; ELECTRONIC SIGNATURES General Provisions § 11.3 Definitions. (a) The definitions and interpretations of terms... definitions of terms also apply to this part: (1) Act means the Federal Food, Drug, and Cosmetic Act (secs...

21 CFR 11.3 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 1 2014-04-01 2014-04-01 false Definitions. 11.3 Section 11.3 Food and Drugs FOOD...; ELECTRONIC SIGNATURES General Provisions § 11.3 Definitions. (a) The definitions and interpretations of terms... definitions of terms also apply to this part: (1) Act means the Federal Food, Drug, and Cosmetic Act (secs...

10 CFR 72.122 - Overall requirements.

Code of Federal Regulations, 2010 CFR

2010-01-01

... § 72.122 Overall requirements. (a) Quality Standards. Structures, systems, and components important to... natural phenomena. (1) Structures, systems, and components important to safety must be designed to... accidents. (2)(i) Structures, systems, and components important to safety must be designed to withstand the...

STS-113 crew during M-113 armored personnel carrier training

NASA Technical Reports Server (NTRS)

2002-01-01

KENNEDY SPACE CENTER, FLA. -- STS-113 Mission Specialist John Herrington stands inside an M-113 armored personnel carrier that he is about to drive as part of emergency egress training during Terminal Countdown Demonstration Test activities. He and the rest of the crew are preparing for the mission aboard Space Shuttle Endeavour, which is scheduled to launch Nov. 10. The TCDT includes a simulated launch countdown. The primary payloads on mission STS-113 are the first port truss segment, P1, and the Crew and Equipment Translation Aid (CETA) Cart B. Once delivered, the P1 truss will remain stowed until flight 12A.1 in 2003 when it will be attached to the central truss segment, S0, on the Space Station. Also onboard Space Shuttle Endeavour will be the Expedition 6 crew who will replace Expedition 5, returning to Earth after 4 months.

The key to commercial-scale geological CO2 sequestration: Displaced fluid management

USGS Publications Warehouse

Surdam, R.C.; Jiao, Z.; Stauffer, P.; Miller, T.

2011-01-01

The Wyoming State Geological Survey has completed a thorough inventory and prioritization of all Wyoming stratigraphic units and geologic sites capable of sequestering commercial quantities of CO2 (5-15 Mt CO 2/year). This multi-year study identified the Paleozoic Tensleep/Weber Sandstone and Madison Limestone (and stratigraphic equivalent units) as the leading clastic and carbonate reservoir candidates for commercial-scale geological CO2 sequestration in Wyoming. This conclusion was based on unit thickness, overlying low permeability lithofacies, reservoir storage and continuity properties, regional distribution patterns, formation fluid chemistry characteristics, and preliminary fluid-flow modeling. This study also identified the Rock Springs Uplift in southwestern Wyoming as the most promising geological CO2 sequestration site in Wyoming and probably in any Rocky Mountain basin. The results of the WSGS CO2 geological sequestration inventory led the agency and colleagues at the UW School of Energy Resources Carbon Management Institute (CMI) to collect available geologic, petrophysical, geochemical, and geophysical data on the Rock Springs Uplift, and to build a regional 3-D geologic framework model of the Uplift. From the results of these tasks and using the FutureGen protocol, the WSGS showed that on the Rock Springs Uplift, the Weber Sandstone has sufficient pore space to sequester 18 billion tons (Gt) of CO2, and the Madison Limestone has sufficient pore space to sequester 8 Gt of CO2. ?? 2011 Published by Elsevier Ltd.

7 CFR 4280.122 - Project eligibility.

Code of Federal Regulations, 2011 CFR

2011-01-01

... RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE LOANS AND GRANTS Renewable Energy Systems and Energy... necessary capital improvements to an existing renewable energy system. ... 7 Agriculture 15 2011-01-01 2011-01-01 false Project eligibility. 4280.122 Section 4280.122...

Sedimentary reservoir oxidation during geologic CO2 sequestration

NASA Astrophysics Data System (ADS)

Lammers, Laura N.; Brown, Gordon E.; Bird, Dennis K.; Thomas, Randal B.; Johnson, Natalie C.; Rosenbauer, Robert J.; Maher, Katharine

2015-04-01

Injection of carbon dioxide into subsurface geologic reservoirs during geologic carbon sequestration (GCS) introduces an oxidizing supercritical CO2 phase into a subsurface geologic environment that is typically reducing. The resulting redox disequilibrium provides the chemical potential for the reduction of CO2 to lower free energy organic species. However, redox reactions involving carbon typically require the presence of a catalyst. Iron oxide minerals, including magnetite, are known to catalyze oxidation and reduction reactions of C-bearing species. If the redox conditions in the reservoir are modified by redox transformations involving CO2, such changes could also affect mineral stability, leading to dissolution and precipitation reactions and alteration of the long-term fate of CO2 in GCS reservoirs. We present experimental evidence that reservoirs with reducing redox conditions are favorable environments for the relatively rapid abiotic reduction of CO2 to organic molecules. In these experiments, an aqueous suspension of magnetite nanoparticles was reacted with supercritical CO2 under pressure and temperature conditions relevant to GCS in sedimentary reservoirs (95-210 °C and ∼100 bars of CO2). Hydrogen production was observed in several experiments, likely caused by Fe(II) oxidation either at the surface of magnetite or in the aqueous phase. Heating of the Fe(II)-rich system resulted in elevated PH2 and conditions favorable for the reduction of CO2 to acetic acid. Implications of these results for the long-term fate of CO2 in field-scale systems were explored using reaction path modeling of CO2 injection into reservoirs containing Fe(II)-bearing primary silicate minerals, with kinetic parameters for CO2 reduction obtained experimentally. The results of these calculations suggest that the reaction of CO2 with reservoir constituents will occur in two primary stages (1) equilibration of CO2 with organic acids resulting in mineral-fluid disequilibrium, and

7 CFR 920.122 - Nomination procedures.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 8 2014-01-01 2014-01-01 false Nomination procedures. 920.122 Section 920.122 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE KIWIFRUIT GROWN IN CALIFORNIA...

7 CFR 920.122 - Nomination procedures.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 8 2011-01-01 2011-01-01 false Nomination procedures. 920.122 Section 920.122 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE KIWIFRUIT GROWN IN CALIFORNIA...

7 CFR 920.122 - Nomination procedures.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 8 2012-01-01 2012-01-01 false Nomination procedures. 920.122 Section 920.122 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE KIWIFRUIT GROWN IN CALIFORNIA...

7 CFR 920.122 - Nomination procedures.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 8 2013-01-01 2013-01-01 false Nomination procedures. 920.122 Section 920.122 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE KIWIFRUIT GROWN IN CALIFORNIA...

7 CFR 920.122 - Nomination procedures.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Nomination procedures. 920.122 Section 920.122 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE KIWIFRUIT GROWN IN CALIFORNIA...

STS-113 crew during M-113 armored personnel carrier training

NASA Technical Reports Server (NTRS)

2002-01-01

KENNEDY SPACE CENTER, FLA. -- STS-113 Mission Specialist John Herrington is at the wheel of an M-113 armored personnel carrier during emergency egress training at the pad. He is accompanied by (left) Mission Specialist Michael Lopez-Alegria and Commander James Wetherbee. The crew is preparing for the mission aboard Space Shuttle Endeavour, which is scheduled to launch Nov. 10, by taking part in Terminal Countdown Demonstration Test activities. The TCDT includes a simulated launch countdown.. The primary payloads on mission STS-113 are the first port truss segment, P1, and the Crew and Equipment Translation Aid (CETA) Cart B. Once delivered, the P1 truss will remain stowed until flight 12A.1 in 2003 when it will be attached to the central truss segment, S0, on the Space Station. Also onboard Space Shuttle Endeavour will be the Expedition 6 crew who will replace Expedition 5, returning to Earth after 4 months.

STS-113 crew during M-113 armored personnel carrier training

NASA Technical Reports Server (NTRS)

2002-01-01

KENNEDY SPACE CENTER, FLA. -- STS-113 Mission Specialist Michael Lopez-Alegria concentrates on driving an M-113 armored personnel carrier during emergency egress training at the pad. He is accompanied by (far left) Mission Specialist John Herrington and Commander James Wetherbee. Behind Lopez-Alegria is Pilot Paul Lockhart. The crew is preparing for the mission aboard Space Shuttle Endeavour, which is scheduled to launch Nov. 10, by taking part in Terminal Countdown Demonstration Test activities. The TCDT includes a simulated launch countdown.. The primary payloads on mission STS-113 are the first port truss segment, P1, and the Crew and Equipment Translation Aid (CETA) Cart B. Once delivered, the P1 truss will remain stowed until flight 12A.1 in 2003 when it will be attached to the central truss segment, S0, on the Space Station. Also onboard Space Shuttle Endeavour will be the Expedition 6 crew who will replace Expedition 5, returning to Earth after 4 months.

STS-113 crew during M-113 armored personnel carrier training

NASA Technical Reports Server (NTRS)

2002-01-01

KENNEDY SPACE CENTER, FLA. -- STS-113 Pilot Paul Lockhart test drives an M-113 armored personnel carrier, part of emergency egress training during Terminal Countdown Demonstration Test activities. He is accompanied by several other crew members, seen at left, Mission Specialist Michael Lopez-Alegria and Commander James Wetherbee. The crew is preparing for the mission aboard Space Shuttle Endeavour, which is scheduled to launch Nov. 10. The TCDT includes a simulated launch countdown. The primary payloads on mission STS-113 are the first port truss segment, P1, and the Crew and Equipment Translation Aid (CETA) Cart B. Once delivered, the P1 truss will remain stowed until flight 12A.1 in 2003 when it will be attached to the central truss segment, S0, on the Space Station. Also onboard Space Shuttle Endeavour will be the Expedition 6 crew who will replace Expedition 5, returning to Earth after 4 months.

STS-113 crew during M-113 armored personnel carrier training

NASA Technical Reports Server (NTRS)

2002-01-01

KENNEDY SPACE CENTER, FLA. - STS-113 Mission Specialist Michael Lopez-Alegria is ready to begin a test drive behind the wheel of an M-113 armored personnel carrier during emergency egress training at the pad. He and the rest of the crew are preparing for the mission aboard Space Shuttle Endeavour, which is scheduled to launch Nov. 10, by taking part in Terminal Countdown Demonstration Test activities. The TCDT includes a simulated launch countdown. The primary payloads on mission STS-113 are the first port truss segment, P1, and the Crew and Equipment Translation Aid (CETA) Cart B. Once delivered, the P1 truss will remain stowed until flight 12A.1 in 2003 when it will be attached to the central truss segment, S0, on the Space Station. Also onboard Space Shuttle Endeavour will be the Expedition 6 crew who will replace Expedition 5, returning to Earth after 4 months.

40 CFR 1065.122 - Engine cooling and lubrication.

Code of Federal Regulations, 2011 CFR

2011-07-01

....122 Section 1065.122 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS ENGINE-TESTING PROCEDURES Equipment Specifications § 1065.122 Engine cooling and lubrication. (a) Engine cooling. Cool the engine during testing so its intake-air, oil, coolant, block, and...

40 CFR 1065.122 - Engine cooling and lubrication.

Code of Federal Regulations, 2010 CFR

2010-07-01

....122 Section 1065.122 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS ENGINE-TESTING PROCEDURES Equipment Specifications § 1065.122 Engine cooling and lubrication. (a) Engine cooling. Cool the engine during testing so its intake-air, oil, coolant, block, and...

40 CFR 1065.122 - Engine cooling and lubrication.

Code of Federal Regulations, 2013 CFR

2013-07-01

....122 Section 1065.122 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS ENGINE-TESTING PROCEDURES Equipment Specifications § 1065.122 Engine cooling and lubrication. (a) Engine cooling. Cool the engine during testing so its intake-air, oil, coolant, block, and...

40 CFR 1065.122 - Engine cooling and lubrication.

Code of Federal Regulations, 2012 CFR

2012-07-01

....122 Section 1065.122 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS ENGINE-TESTING PROCEDURES Equipment Specifications § 1065.122 Engine cooling and lubrication. (a) Engine cooling. Cool the engine during testing so its intake-air, oil, coolant, block, and...

40 CFR 1065.122 - Engine cooling and lubrication.

Code of Federal Regulations, 2014 CFR

2014-07-01

....122 Section 1065.122 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS ENGINE-TESTING PROCEDURES Equipment Specifications § 1065.122 Engine cooling and lubrication. (a) Engine cooling. Cool the engine during testing so its intake-air, oil, coolant, block, and...

27 CFR 53.113 - Events subsequent to taxable use of article.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false Events subsequent to taxable use of article. 53.113 Section 53.113 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO... Importer Considered Sale § 53.113 Events subsequent to taxable use of article. Liability for tax incurred...

27 CFR 53.113 - Events subsequent to taxable use of article.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 27 Alcohol, Tobacco Products and Firearms 2 2014-04-01 2014-04-01 false Events subsequent to taxable use of article. 53.113 Section 53.113 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO... Importer Considered Sale § 53.113 Events subsequent to taxable use of article. Liability for tax incurred...

27 CFR 53.113 - Events subsequent to taxable use of article.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 27 Alcohol, Tobacco Products and Firearms 2 2011-04-01 2011-04-01 false Events subsequent to taxable use of article. 53.113 Section 53.113 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO... Importer Considered Sale § 53.113 Events subsequent to taxable use of article. Liability for tax incurred...

27 CFR 53.113 - Events subsequent to taxable use of article.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 27 Alcohol, Tobacco Products and Firearms 2 2013-04-01 2013-04-01 false Events subsequent to taxable use of article. 53.113 Section 53.113 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO... Importer Considered Sale § 53.113 Events subsequent to taxable use of article. Liability for tax incurred...

27 CFR 53.113 - Events subsequent to taxable use of article.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 27 Alcohol, Tobacco Products and Firearms 2 2012-04-01 2011-04-01 true Events subsequent to taxable use of article. 53.113 Section 53.113 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO... Importer Considered Sale § 53.113 Events subsequent to taxable use of article. Liability for tax incurred...

Lopez-Alegria and Herrington work near CETA cart 2 during STS-113 EVA OPS

NASA Image and Video Library

2002-11-26

STS113-714-033 (26-30 November 2002) --- Astronauts Michael E. Lopez-Alegria (right) and John B. Herrington, STS-113 mission specialists, work near the Crew and Equipment Translation Aid (CETA) cart on a truss on the International Space Station (ISS) during a scheduled spacewalk for the mission.

38 CFR 4.122 - Psychomotor epilepsy.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Psychomotor epilepsy. 4.122 Section 4.122 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS SCHEDULE FOR..., macropsia, micropsia, dreamy states), alterations in thinking (not open to reason), alterations in memory...

19 CFR 122.75 - Complete manifest.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 19 Customs Duties 1 2010-04-01 2010-04-01 false Complete manifest. 122.75 Section 122.75 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY AIR COMMERCE REGULATIONS Documents Required for Clearance and Permission To Depart; Electronic...

19 CFR 122.42 - Aircraft entry.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 19 Customs Duties 1 2010-04-01 2010-04-01 false Aircraft entry. 122.42 Section 122.42 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY AIR COMMERCE REGULATIONS Aircraft Entry and Entry Documents; Electronic Manifest Requirements for...

19 CFR 122.77 - Clearance certificate.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 19 Customs Duties 1 2010-04-01 2010-04-01 false Clearance certificate. 122.77 Section 122.77 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY AIR COMMERCE REGULATIONS Documents Required for Clearance and Permission To Depart; Electronic...

19 CFR 122.45 - Crew list.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 19 Customs Duties 1 2010-04-01 2010-04-01 false Crew list. 122.45 Section 122.45 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY AIR COMMERCE REGULATIONS Aircraft Entry and Entry Documents; Electronic Manifest Requirements for Passengers...

49 CFR 380.113 - Employer responsibilities.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 5 2010-10-01 2010-10-01 false Employer responsibilities. 380.113 Section 380.113 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER SAFETY....113 Employer responsibilities. (a) No motor carrier shall: (1) Allow, require, permit or authorize an...

STS-122 crew portrait

NASA Image and Video Library

2006-07-21

STS122-S-002 (24 April 2007) --- These seven astronauts take a break from training to pose for the STS-122 crew portrait. From the left (front row) are astronauts Stephen N. Frick, commander; European Space Agency's (ESA) Leopold Eyharts; and Alan G. Poindexter, pilot. From the left (back row) are astronauts Leland D. Melvin, Rex J. Walheim, Stanley G. Love and European Space Agency's (ESA) Hans Schlegel, all mission specialists. Eyharts will join Expedition 16 in progress to serve as a flight engineer aboard the International Space Station. The crewmembers are attired in training versions of their shuttle launch and entry suits.

The basis of distinctive IL-2- and IL-15-dependent signaling: weak CD122-dependent signaling favors CD8+ T central-memory cell survival but not T effector-memory cell development.

PubMed

Castro, Iris; Yu, Aixin; Dee, Michael J; Malek, Thomas R

2011-11-15

Recent work suggests that IL-2 and IL-15 induce distinctive levels of signaling through common receptor subunits and that such varied signaling directs the fate of Ag-activated CD8(+) T cells. In this study, we directly examined proximal signaling by IL-2 and IL-15 and CD8(+) T cell primary and memory responses as a consequence of varied CD122-dependent signaling. Initially, IL-2 and IL-15 induced similar p-STAT5 and p-S6 activation, but these activities were only sustained by IL-2. Transient IL-15-dependent signaling is due to limited expression of IL-15Rα. To investigate the outcome of varied CD122 signaling for CD8(+) T cell responses in vivo, OT-I T cells were used from mouse models where CD122 signals were attenuated by mutations within the cytoplasmic tail of CD122 or intrinsic survival function was provided in the absence of CD122 expression by transgenic Bcl-2. In the absence of CD122 signaling, generally normal primary response occurred, but the primed CD8(+) T cells were not maintained. In marked contrast, weak CD122 signaling supported development and survival of T central-memory (T(CM)) but not T effector-memory (T(EM)) cells. Transgenic expression of Bcl-2 in CD122(-/-) CD8(+) T cells also supported the survival and persistence of T(CM) cells but did not rescue T(EM) development. These data indicate that weak CD122 signals readily support T(CM) development largely through providing survival signals. However, stronger signals, independent of Bcl-2, are required for T(EM) development. Our findings are consistent with a model whereby low, intermediate, and high CD122 signaling support T(CM) memory survival, T(EM) programming, and terminal T effector cell differentiation, respectively.

46 CFR 122.518 - Inflatable survival craft placards.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Inflatable survival craft placards. 122.518 Section 122... Preparations for Emergencies § 122.518 Inflatable survival craft placards. (a) Every vessel equipped with an inflatable survival craft must have approved placards or other cards containing instructions for launching...

46 CFR 122.202 - Notice of marine casualty.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 4 2014-10-01 2014-10-01 false Notice of marine casualty. 122.202 Section 122.202... THAN 150 PASSENGERS OR WITH OVERNIGHT ACCOMMODATIONS FOR MORE THAN 49 PASSENGERS OPERATIONS Marine Casualties and Voyage Records § 122.202 Notice of marine casualty. (a) Immediately after addressing resultant...

46 CFR 122.202 - Notice of marine casualty.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 4 2012-10-01 2012-10-01 false Notice of marine casualty. 122.202 Section 122.202... THAN 150 PASSENGERS OR WITH OVERNIGHT ACCOMMODATIONS FOR MORE THAN 49 PASSENGERS OPERATIONS Marine Casualties and Voyage Records § 122.202 Notice of marine casualty. (a) Immediately after addressing resultant...

46 CFR 122.202 - Notice of marine casualty.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 4 2011-10-01 2011-10-01 false Notice of marine casualty. 122.202 Section 122.202... THAN 150 PASSENGERS OR WITH OVERNIGHT ACCOMMODATIONS FOR MORE THAN 49 PASSENGERS OPERATIONS Marine Casualties and Voyage Records § 122.202 Notice of marine casualty. (a) Immediately after addressing resultant...

46 CFR 122.202 - Notice of marine casualty.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Notice of marine casualty. 122.202 Section 122.202... THAN 150 PASSENGERS OR WITH OVERNIGHT ACCOMMODATIONS FOR MORE THAN 49 PASSENGERS OPERATIONS Marine Casualties and Voyage Records § 122.202 Notice of marine casualty. (a) Immediately after addressing resultant...

46 CFR 122.202 - Notice of marine casualty.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 4 2013-10-01 2013-10-01 false Notice of marine casualty. 122.202 Section 122.202... THAN 150 PASSENGERS OR WITH OVERNIGHT ACCOMMODATIONS FOR MORE THAN 49 PASSENGERS OPERATIONS Marine Casualties and Voyage Records § 122.202 Notice of marine casualty. (a) Immediately after addressing resultant...

Evaluation of plasma microRNA-122, high-mobility group box 1 and keratin-18 concentrations to stratify acute gallstone disease: a pilot observational cohort study in an emergency general surgery unit.

PubMed

Th'ng, Francesca; Vliegenthart, Bastiaan; Lea, Jonathan D; Antoine, Daniel J; Dear, James W; Mole, Damian J

2018-04-27

To obtain pilot data to evaluate the discriminatory power of biomarkers microRNA-122 (miR-122), high-mobility group box 1 (HMGB1), full-length keratin-18 (flk-18) and caspase-cleaved keratin-18 (cck-18) in plasma to identify potential biliary complications that may require acute intervention. An observational biomarker cohort pilot study. In a Scottish University teaching hospital for 12 months beginning on 3 September 2014. Blood samples were collected from adults (≥16 years old) referred with acute biliary-type symptoms who have presented to hospital within 24 hours prior were recruited. Patients unable or refused to give informed consent or were transferred from a hospital outside the National Health Service regional trust were excluded. To evaluate whether circulating miR-122, HMGB1, flk-18 and cck-18 can discriminate between people with and without gallstone disease and uncomplicated from complicated gallstone disease during the first 24 hours of hospital admission. 300 patients were screened of which 285 patients were included. Plasma miR-122, cck-18 and flk-18 concentrations were increased in patients with gallstones compared with those without (miR-122: median: 2.89×10 4  copies/mL vs 0.90×10 4  copies/mL (p<0.001); cck-18: 121.2 U/L vs 103.5 U/L (p=0.031); flk-18: 252.4 U/L vs 145.1 U/L (p<0.001)). Uncomplicated gallstone disease was associated with higher miR-122 and cck-18 concentrations than complicated disease (miR-122: 5.72×10 4  copies/mL vs 2.26×10 4  copies/mL (p=0.023); cck-18: 139.7 U/L vs 113.6 U/L (p=0.047)). There was no significant difference in HMGB1 concentration between patients with and without gallstones (p=0.559). Separation between groups for all biomarkers was modest. miR-122 and keratin-18 plasma concentrations are elevated in patients with gallstones. However, this result is confounded by the association between biomarker concentrations, age and gender. In this pilot study, miR-122 and keratin-18 were

48 CFR 49.113 - Cost principles.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Cost principles. 49.113 Section 49.113 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 49.113 Cost principles. The cost principles and procedures in the...

14 CFR 1240.113 - Financial accounting.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Financial accounting. 1240.113 Section 1240.113 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION INVENTIONS AND CONTRIBUTIONS Awards for Scientific and Technical Contributions § 1240.113 Financial accounting. (a) An Award Check...

40 CFR 122.37 - Will the small MS4 storm water program regulations at §§ 122.32 through 122.36 and § 123.35 of...

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 23 2012-07-01 2012-07-01 false Will the small MS4 storm water program... Special NPDES Program Requirements § 122.37 Will the small MS4 storm water program regulations at §§ 122... evaluation of the NPDES MS4 storm water program. EPA will re-evaluate the regulations based on data from the...

40 CFR 122.37 - Will the small MS4 storm water program regulations at §§ 122.32 through 122.36 and § 123.35 of...

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 23 2013-07-01 2013-07-01 false Will the small MS4 storm water program... Special NPDES Program Requirements § 122.37 Will the small MS4 storm water program regulations at §§ 122... evaluation of the NPDES MS4 storm water program. EPA will re-evaluate the regulations based on data from the...

40 CFR 122.37 - Will the small MS4 storm water program regulations at §§ 122.32 through 122.36 and § 123.35 of...

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 22 2014-07-01 2013-07-01 true Will the small MS4 storm water program... Special NPDES Program Requirements § 122.37 Will the small MS4 storm water program regulations at §§ 122... evaluation of the NPDES MS4 storm water program. EPA will re-evaluate the regulations based on data from the...

TED Study of Si(113) Surfaces

NASA Astrophysics Data System (ADS)

Suzuki, T.; Minoda, H.; Tanishiro, Y.; Yagi, K.

A TED study of Si(113) surfaces was carried out. Reflections from the 3 × 2 reconstruction were seen at room temperature, while half-order reflections were very faint. The surface showed the phase transition between the 3 × 1 and the disordered (rough) structures at about 930°C. The (113) surface structure at room temperature was analyzed using TED intensity. Four kinds of structure models proposed previously, including both the 3 × 1 and the 3 × 2 reconstructed structures, were examined. The R-factors calculated using the energy-optimized atomic coordinates are not sufficiently small. After minimization of the R-factors, Dabrowski's 3 × 2 structure model is most agreeable, while Ranke's 3 × 1 and 3 × 2 structure models are not to be excluded. STM observation showed that the surface is composed of small domains of the 3 × 2 structure.

28 CFR 115.122 - Policies to ensure referrals of allegations for investigations.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Policies to ensure referrals of allegations for investigations. 115.122 Section 115.122 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PRISON RAPE ELIMINATION ACT NATIONAL STANDARDS Standards for Lockups Responsive Planning § 115...

28 CFR 115.122 - Policies to ensure referrals of allegations for investigations.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Policies to ensure referrals of allegations for investigations. 115.122 Section 115.122 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PRISON RAPE ELIMINATION ACT NATIONAL STANDARDS Standards for Lockups Responsive Planning § 115...

28 CFR 115.122 - Policies to ensure referrals of allegations for investigations.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Policies to ensure referrals of allegations for investigations. 115.122 Section 115.122 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PRISON RAPE ELIMINATION ACT NATIONAL STANDARDS Standards for Lockups Responsive Planning § 115...

19 CFR 122.5 - Reproduction of Customs forms.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 19 Customs Duties 1 2011-04-01 2011-04-01 false Reproduction of Customs forms. 122.5 Section 122.5 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY AIR COMMERCE REGULATIONS General Definitions and Provisions § 122.5 Reproduction of Customs forms...

19 CFR 122.5 - Reproduction of Customs forms.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 19 Customs Duties 1 2010-04-01 2010-04-01 false Reproduction of Customs forms. 122.5 Section 122.5 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY AIR COMMERCE REGULATIONS General Definitions and Provisions § 122.5 Reproduction of Customs forms...

19 CFR 122.35 - Emergency or forced landing.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 19 Customs Duties 1 2011-04-01 2011-04-01 false Emergency or forced landing. 122.35 Section 122.35... TREASURY AIR COMMERCE REGULATIONS Landing Requirements § 122.35 Emergency or forced landing. (a) Application. This section applies to emergency or forced landings made by aircraft when necessary for safety...

19 CFR 122.35 - Emergency or forced landing.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 19 Customs Duties 1 2010-04-01 2010-04-01 false Emergency or forced landing. 122.35 Section 122.35... TREASURY AIR COMMERCE REGULATIONS Landing Requirements § 122.35 Emergency or forced landing. (a) Application. This section applies to emergency or forced landings made by aircraft when necessary for safety...

19 CFR 122.157 - Documents required for clearance.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 19 Customs Duties 1 2010-04-01 2010-04-01 false Documents required for clearance. 122.157 Section 122.157 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY AIR COMMERCE REGULATIONS Flights to and From Cuba § 122.157 Documents required for...

38 CFR 16.122 - Use of Federal funds.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 1 2011-07-01 2011-07-01 false Use of Federal funds. 16.122 Section 16.122 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS PROTECTION OF HUMAN SUBJECTS § 16.122 Use of Federal funds. Federal funds administered by a department or agency...

38 CFR 16.122 - Use of Federal funds.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Use of Federal funds. 16.122 Section 16.122 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS PROTECTION OF HUMAN SUBJECTS § 16.122 Use of Federal funds. Federal funds administered by a department or agency...

14 CFR 1245.113 - Hearing procedure.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Hearing procedure. 1245.113 Section 1245.113 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PATENTS AND OTHER INTELLECTUAL PROPERTY RIGHTS Patent Waiver Regulations § 1245.113 Hearing procedure. (a) If the petitioner requests an...

46 CFR 113.30-1 - Applicability.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 4 2014-10-01 2014-10-01 false Applicability. 113.30-1 Section 113.30-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) ELECTRICAL ENGINEERING COMMUNICATION AND ALARM SYSTEMS AND EQUIPMENT Internal Communications § 113.30-1 Applicability. This subpart applies to each self...

46 CFR 113.40-1 - Applicability.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 4 2012-10-01 2012-10-01 false Applicability. 113.40-1 Section 113.40-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) ELECTRICAL ENGINEERING COMMUNICATION AND ALARM SYSTEMS AND EQUIPMENT Rudder Angle Indicator Systems § 113.40-1 Applicability. This subpart applies to...

46 CFR 113.30-1 - Applicability.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 4 2012-10-01 2012-10-01 false Applicability. 113.30-1 Section 113.30-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) ELECTRICAL ENGINEERING COMMUNICATION AND ALARM SYSTEMS AND EQUIPMENT Internal Communications § 113.30-1 Applicability. This subpart applies to each self...

46 CFR 113.30-1 - Applicability.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Applicability. 113.30-1 Section 113.30-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) ELECTRICAL ENGINEERING COMMUNICATION AND ALARM SYSTEMS AND EQUIPMENT Internal Communications § 113.30-1 Applicability. This subpart applies to each self...

46 CFR 113.30-1 - Applicability.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 4 2011-10-01 2011-10-01 false Applicability. 113.30-1 Section 113.30-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) ELECTRICAL ENGINEERING COMMUNICATION AND ALARM SYSTEMS AND EQUIPMENT Internal Communications § 113.30-1 Applicability. This subpart applies to each self...

46 CFR 113.40-1 - Applicability.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 4 2014-10-01 2014-10-01 false Applicability. 113.40-1 Section 113.40-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) ELECTRICAL ENGINEERING COMMUNICATION AND ALARM SYSTEMS AND EQUIPMENT Rudder Angle Indicator Systems § 113.40-1 Applicability. This subpart applies to...

46 CFR 113.30-1 - Applicability.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 4 2013-10-01 2013-10-01 false Applicability. 113.30-1 Section 113.30-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) ELECTRICAL ENGINEERING COMMUNICATION AND ALARM SYSTEMS AND EQUIPMENT Internal Communications § 113.30-1 Applicability. This subpart applies to each self...

46 CFR 113.40-1 - Applicability.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 4 2013-10-01 2013-10-01 false Applicability. 113.40-1 Section 113.40-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) ELECTRICAL ENGINEERING COMMUNICATION AND ALARM SYSTEMS AND EQUIPMENT Rudder Angle Indicator Systems § 113.40-1 Applicability. This subpart applies to...

42 CFR 53.113 - Community service.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Community service. 53.113 Section 53.113 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS GRANTS, LOANS AND LOAN... To Pay; Community Service; Nondiscrimination. § 53.113 Community service. (a) Applicability. The...

46 CFR 113.40-1 - Applicability.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 4 2011-10-01 2011-10-01 false Applicability. 113.40-1 Section 113.40-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) ELECTRICAL ENGINEERING COMMUNICATION AND ALARM SYSTEMS AND EQUIPMENT Rudder Angle Indicator Systems § 113.40-1 Applicability. This subpart applies to...

46 CFR 113.40-1 - Applicability.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Applicability. 113.40-1 Section 113.40-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) ELECTRICAL ENGINEERING COMMUNICATION AND ALARM SYSTEMS AND EQUIPMENT Rudder Angle Indicator Systems § 113.40-1 Applicability. This subpart applies to...

46 CFR 122.602 - Hull markings.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Hull markings. 122.602 Section 122.602 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS CARRYING MORE THAN 150....602 Hull markings. (a) Each vessel must be marked as required by part 67, subpart I, of this chapter...

46 CFR 122.508 - Wearing of life jackets.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Wearing of life jackets. 122.508 Section 122.508... Preparations for Emergencies § 122.508 Wearing of life jackets. (a) The master of a vessel shall require passengers to don life jackets when possible hazardous conditions exist, including, but not limited to: (1...

46 CFR 122.508 - Wearing of life jackets.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 4 2011-10-01 2011-10-01 false Wearing of life jackets. 122.508 Section 122.508... Preparations for Emergencies § 122.508 Wearing of life jackets. (a) The master of a vessel shall require passengers to don life jackets when possible hazardous conditions exist, including, but not limited to: (1...

34 CFR 97.122 - Use of Federal funds.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 1 2010-07-01 2010-07-01 false Use of Federal funds. 97.122 Section 97.122 Education Office of the Secretary, Department of Education PROTECTION OF HUMAN SUBJECTS Federal Policy for the Protection of Human Subjects (Basic ED Policy for Protection of Human Research Subjects) § 97.122 Use of...

46 CFR 122.330 - Hatches and other openings.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 4 2013-10-01 2013-10-01 false Hatches and other openings. 122.330 Section 122.330... Miscellaneous Operating Requirements § 122.330 Hatches and other openings. (a) Except when operating on lakes, bays, and sounds, or river routes in calm weather, all hatches and openings in the hull, except loading...

46 CFR 122.330 - Hatches and other openings.

Code of Federal Regulations, 2010 CFR

2010-10-01