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1

Adult Kasabach-Merritt Syndrome due to Hepatic Giant Hemangioma.  

PubMed

Cavernous hemangiomas are the most common benign tumors of the liver. They can reach enormous sizes and cause various complications. Kasabach-Merritt syndrome is a rare but serious complication characterized by consumptive coagulopathy caused by the hemangioma; mortality rate ranges between 10 and 37%. More than 80% of cases occur within the first year of life. Goals of the treatment are to control the coagulopathyand thrombocytopenia as well as to eradicate the hemangioma. Different nonsurgical treatment regimens are performed, includingsystemic corticosteroids, irradiation and various chemicals. Surgery should be limited to symptomatic or complicated cases. Although difficult, resection of the tumor is usually curative. Here we present a 44-year-old woman with giant hepatic hemangioma causing Kasabach-Merritt syndrome managed by enucleation. PMID:21103246

Aslan, Ahmet; Meyer Zu Vilsendorf, Andreas; Kleine, Moritz; Bredt, Martin; Bektas, Hüseyin

2009-01-01

2

Adult Kasabach-Merritt Syndrome due to Hepatic Giant Hemangioma  

PubMed Central

Cavernous hemangiomas are the most common benign tumors of the liver. They can reach enormous sizes and cause various complications. Kasabach-Merritt syndrome is a rare but serious complication characterized by consumptive coagulopathy caused by the hemangioma; mortality rate ranges between 10 and 37%. More than 80% of cases occur within the first year of life. Goals of the treatment are to control the coagulopathyand thrombocytopenia as well as to eradicate the hemangioma. Different nonsurgical treatment regimens are performed, includingsystemic corticosteroids, irradiation and various chemicals. Surgery should be limited to symptomatic or complicated cases. Although difficult, resection of the tumor is usually curative. Here we present a 44-year-old woman with giant hepatic hemangioma causing Kasabach-Merritt syndrome managed by enucleation.

Aslan, Ahmet; Meyer zu Vilsendorf, Andreas; Kleine, Moritz; Bredt, Martin; Bektas, Huseyin

2009-01-01

3

Giant cavernous hemangioma coexistent with diffuse hepatic hemangiomatosis presenting as portal vein thrombosis and hepatic lobar atrophy  

PubMed Central

A combination of giant hepatic hemangioma and diffuse hemangiomatosis is extremely rare in adults. Even when they are large, hemangiomas are soft and rarely compress adjacent structures. A 78-year-old man presented with abdominal pain and distension. Ultrasonography, computed tomography, and magnetic resonance imaging demonstrated a large expansile mass replacing the medial segment and caudate lobe with diffusely scattered nodules in the entire liver. The large hilar mass contained a central nonenhancing area and had a mass effect, leading to left portal vein occlusion. The image findings also revealed two unprecedented findings: left lateral segmental atrophy of the liver and recent portomesenteric vein thrombosis. The hepatic lesions were confirmed with hemangiomas by ultrasonography-guided biopsy. We diagnosed intrahepatic portal vein obstruction caused by a mass effect of giant hepatic hemangioma coexistent with diffuse hemangiomatosis, resulting in hepatic segmental atrophy and extrahepatic portal vein thrombosis.

2014-01-01

4

Case report: living donor liver transplantation for giant hepatic hemangioma using a right lobe graft without the middle hepatic vein  

PubMed Central

Hepatic hemangioma patients with Kasabach-Merritt syndrome have reportedly been cured by liver transplantation. However, liver transplantation as a potential cure for a stable patient without Kasabach-Merritt syndrome remains debatable. We report the case of a 27-year-old female patient with a giant hepatic hemangioma. The hemangioma measured 50?×?40?×?25 cm in size and weighed 15 kg, which is the largest and heaviest hemangioma reported in the literature. The patient showed jaundice, ascites, anemia, and appetite loss; but no disseminated intravascular coagulation was observed through laboratory findings. We successfully operated using a right lobe graft without the middle hepatic vein from a 55-year-old donor. At the long-term follow-up, the patient experienced two acute rejections, which were confirmed by biopsy. However, the patient still survives with good graft function after 50 months.

2014-01-01

5

Giant hepatic hemangioma and cross-fused ectopic kidney in a spaceflight participant.  

PubMed

Commercial spaceflight participants are typically older than traditional astronauts and often have medical conditions that make medical certification for flight difficult. This case report considers a 43-yr-old spaceflight participant who planned a short-duration Soyuz flight to the International Space Station (ISS). While he participated in many hazardous activities such as parachuting, hang gliding, scuba diving, Antarctic and jungle exploration, and deep sea submersible operations, he knew that several of his medical conditions precluded serving as a career astronaut. At the time of his initial spaceflight prescreen examination, he was known to have previous bilateral photorefractive keratectomy (PRK) for myopia and a cross-fused left ectopic kidney that would be disqualifying for a career astronaut. During the evaluation for the left single cross-fused ectopic kidney, a giant hepatic hemangioma was also discovered. In order to medically qualify for flight, the giant hepatic hemangioma was surgically removed. This case summary investigat*es the implications of a single cross-fused left ectopic kidney and the decision process and treatment implications for spaceflight medical certification in an individual with an asymptomatic giant hepatic hemangioma. PMID:20131656

Jennings, Richard T; Garriott, Owen K; Bogomolov, Valery V; Pochuev, Vladimir I; Morgun, Valery V; Garriott, Richard A

2010-02-01

6

Diagnosis and Management of Giant Hepatic Hemangioma: The Usefulness of Contrast-Enhanced Ultrasonography  

PubMed Central

Giant hepatic hemangiomas, though often asymptomatic, may require intervention if rapid growth occurs. The imaging studies including the computed tomography, magnetic resonance imaging, and ultrasonography, and so on are effective for the diagnosis and the management of this tumor; however, due to its size and various patterns of these studies, we need to carefully consider the therapeutic methods. Compared to the cost needed for these modalities, recently developed and approved Perflubutane- (Sonazoid-) based contrast agent enhanced ultrasonography is reasonable and safe. The major advantage is the real-time observation of the vascular structure and function of the Kupffer cells. By this procedure, we can carefully follow the tumor growth or character change in a hemangioma and decide the timing of therapeutic intervention, since abdominal pain, abdominal mass, consumptive coagulopathy, and hemangioma growth are the signs for the therapeutic intervention. We reviewed recent reports about Sonazoid-based enhancement and also showed the representative images collected in our department. This is the first review showing the detailed findings of the giant hemangiomas using Perflubutane (Sonazoid). This review will help the physician in making the decision, and we hope that Sonazoid will gain widespread acceptance in the near future.

Isokawa, Osamu; Hoshiyama, Koki; Hoshiyama, Ayako; Hoshiyama, Mari; Hoshiyama, Yoshihiro

2013-01-01

7

Giant infantile pulmonary hemangioma.  

PubMed

We present a very unusual case of giant infantile pulmonary hemangioma presenting as a large solitary pulmonary mass. This was successfully managed with surgical resection. Histological examination revealed that the mass was positive for GLUT-1 receptor, a marker for infantile hemangioma. To our knowledge only a few cases of pulmonary hemangioma have been described previously in the literature. Pulmonary hemangiomas are very rare lesions, most of them presenting as a pulmonary mass. This case emphasizes the fact that this rare lesion should be considered in the differential of an enhancing pulmonary mass in an infant. PMID:20461368

Pandya, Rajul; Tummala, Venkat

2010-12-01

8

Ultrasound (US) and computed tomographic (CT) appearances of large (giant) hepatic cavernous hemangiomas.  

PubMed

The sonographic and CT appearances of 9 large cavernous hemangiomas of the liver were studied. On sonography, 6 masses (67%) exhibit heterogenous echo pattern; where in 2 patients the echotexture was a mixture of hypoechoic and isoechoic areas and in 4 patients there are varying amounts of bright hyperreflective areas similar to the texture typical of small hemangiomas. The masses were predominantly hypoechoic in the remaining 3 patients (33%). Incremental bolus or bolus-infusion dynamic CT showed peripheral contrast enhancement of varying intensities and thickness in all patients. The lesions were incorrectly diagnosed as hepatomas in 4 patients, suspected as hemangiomas with a differential diagnosis of hepatomas in 4 patients and an early liver abscess in 1 patient. It is concluded that large cavernous hemangiomas of the liver do not exhibit the typical homogenous hyperreflective echotexture as exhibited by small lesions and they mimic primary and secondary hepatic neoplasms. However, the diagnosis of hemangioma should be entertained when such a mass contains bright hyperechoic areas within its heterogenous echo pattern and exhibit peripheral enhancement on contrast enhanced CT. In addition to correlation with appropriate clinical information, confirmation of diagnosis include delayed scanning during a routine incremental bolus dynamic CT, single-slice dynamic contrast enhanced CT, angiography or isotope scintigraphy and magnetic resonance imaging depending on the availability of facility. PMID:7752982

Samad, S A; Maimunah, A; Zulfiqar, A; Zaharah, M

1995-03-01

9

Living donor liver transplantation in a patient with giant hepatic hemangioma complicated by Kasabach-Merritt syndrome: Report of a case  

Microsoft Academic Search

We herein present a case of unresectable giant hepatic hemangiomas with Kasabach-Merritt syndrome which was successfully treated\\u000a by living donor liver transplantation using a left lobe graft. The patient was a 45-year-old woman who complained of abdominal\\u000a distension. Two sessions of transarterial embolization were performed, but failed to reduce the size of the tumor. The hepatic\\u000a tumors were thus judged

Makoto Meguro; Yuji Soejima; Akinobu Taketomi; Toru Ikegami; Yo-ichi Yamashita; Noboru Harada; Shinji Itoh; Koichi Hirata; Yoshihiko Maehara

2008-01-01

10

Right hepatectomy for giant cavernous hemangioma with diffuse hemangiomatosis around Glisson's capsule  

PubMed Central

Diffuse liver hemangiomatosis with giant cavernous hemangioma in adult is extremely rare. A 35 year-old woman presented to hospital with main complaint of epigastric pain and abdominal fullness. An enhanced computed tomography scan revealed a massive liver tumor in right lobe about 150 mm in size. There was contrast enhancement at the periphery of the mass consistent with a cavernous hemangioma. She underwent right hepatectomy. Histologically, it was diagnosed as a cavernous hemangioma. And also, hemangiomatous lesions were scattered around the Glisson’s capsule on the back ground liver. These hemangiomatous lesions were not recognized preoperatively. Even if we couldn’t diagnose hemangiomatosis around the main giant hemangioma preoperatively, we need to take enough surgical margins because the giant hemangioma has the potential to have small hemangiomatous lesions around the tumor. We reported right hepatectomy for giant cavernous hemangioma with diffuse hepatic hemangiomatosis without an extrahepatic lesion in an adult.

Ohkura, Yu; Hashimoto, Masaji; Lee, Seigi; Sasaki, Kazunari; Matsuda, Masamichi; Watanabe, Goro

2014-01-01

11

Giant cavernous hemangiomas: report of three cases  

Microsoft Academic Search

Giant cavernous hemangiomas occur very rarely, and little has been reported about their behavior. In this case report three cavernous hemangiomas with a diametric measure between 6 cm and 7 cm and distinct features will be described. A 36-year-old female patient presented with headache and nausea. A CT scan disclosed a large circumscribed tumor with strong contrast enhancement in the temporo-parieto-occipital region

E. J. van Lindert; T. C. Tan; J. A. Grotenhuis; P. Wesseling

2007-01-01

12

Polymyalgia rheumatica as a manifestation of a large hepatic cavernous hemangioma.  

PubMed

A 59-year-old woman presented with polymyalgia rheumatica which was refractory to conventional anti-inflammatory and steroid therapy. A full investigation for an underlying occult malignancy showed only the presence of a giant cavernous hepatic hemangioma. To our knowledge, polymyalgia rheumatica has never been described in association with giant cavernous hepatic hemangioma; resection of the latter lesion resulted in complete and, to this date, definite resolution of rheumatologic complaints in our patient. PMID:10707879

Kadry, Z; Mentha, G; Cereda, J M

2000-02-01

13

Embolization for management of hepatic hemangiomas.  

PubMed

Hemangiomas represent the most common primary tumor of the liver. Clinically the significance of these lesions is highly variable. The management of hemangiomas is controversial and is intimately related to the size, symptoms, and associated comorbidities of the patients who harbor these benign tumors. Series suggest that the vast majority of hemangiomas are less than 4 cm, asymptomatic, and clinically incidental findings. Symptomatic hemangiomas are large and associated with a constellation of vague upper abdominal complaints including pain, mass, distention, early satiety, and weight loss. A number of small series of surgically treated symptomatic hemangiomas have demonstrated enucleation as a safe and effective intervention. We report a collection of case reports using embolization as a primary treatment of symptomatic hemangiomas. The first patient is a 73-year-old black man previously treated for prostate cancer by radical prostatectomy and radiation. He developed weight loss, abdominal fullness, and early satiety. His symptoms were attributed to a large left lateral segmental liver mass that was biopsy proven to be a hemangioma. The second patient is a 49-year-old black women who complained of weakness, fatigue, night sweats, and anemia. The only abnormality discovered was a large right posterior hemangioma. The third patient is a 49-year-old black women with unexplained right upper quadrant pain and anemia who was found to have a 19 x 11 x 7.5-cm left hepatic hemangioma by CT. All three patients underwent elective treatment of their hemangiomas with highly selective hepatic embolization. There were no significant complications related to the procedures. Symptoms resolved for all patients acutely after treatment. The use of embolization for hepatic hemangiomas provides safe and effective treatment of the patient's symptoms while avoiding operative intervention, extended hospitalization, or postoperative recuperation. This treatment modality should be considered for the symptomatic hemangioma under elective conditions. PMID:11243541

Deutsch, G S; Yeh, K A; Bates, W B; Tannehill, W B

2001-02-01

14

SPECT in the diagnosis of hepatic hemangioma  

SciTech Connect

Tc99m labeled red blood cell blood flow and delayed static blood pool imaging is widely accepted as a reliable, accurate method for the diagnosis of hepatic hemangiomata. The purpose of this study is to assess the relative value of SPECT blood pool imaging in the evaluation of hepatic hemangionata. A total of 68 patients, including 21 patients with proven hepatic cavernous hemangiomas, were studied using both planar and SPECT imaging techniques. All patients underwent multi-phase evaluation which included a hepatic flow study, immediate planar images of the liver, followed by a 360/sup 0/ tomographic (SPECT) study and subsequent 60 minute delayed static planar hepatic blood pool images. All 21 patients with proven hepatic hemangiomas had a positive SPECT exam and 17 of the 21 (81%) patients had a positive planar exam. In the 21 patients, there were a total of 36 hemangiomas ranging in size from .7 cm to 13 cm. The SPECT imaging technique correctly identified all 36 lesions (100%) where as planar imaging detected 25 of the 36 lesions (69.4%). In all the remaining patients (10-normal, 17-metastatic disease, 12-hepatocellular disease, 6-hepatoma, 2-liver cysts), both the planar and SPECT imaging techniques were interpreted as showing no evidence of focal sequestration of red blood cells. SPECT hepatic blood pool imaging represents an improvement in the evaluation of hepatic hemangioma as a result of a reduction in imaging time (less than thirty minutes), improved spatial resolution and greater overall accuracy.

Brunetti, J.C.; Van Heertum, R.L.; Yudd, A.P.

1985-05-01

15

Chylous Ascites Secondary to Giant Liver Hemangioma  

PubMed Central

Chylous ascites is rare in clinical practice. It is characterized by milky-appearing peritoneal fluid with a triglycerides concentration of >1.25 mmol/l (110 mg/dl). Its pathophysiology is related to a disruption in the normal lymphatic flow. It is more common after trauma (including post surgery), neoplasia or atypical infections such as tuberculosis or filariasis. Other rare medical causes have been reported. The treatment is supportive and focused on correction of the underlying pathology. We report here the first case of chylous ascites caused by giant liver hemangioma and discuss the management of this condition.

Lazarus, Darius L.; Al-Busafi, Said A.; Hilzenrat, Nir

2012-01-01

16

Pathognomonic scintigraphic finding of hepatic cavernous hemangioma  

SciTech Connect

Hemangioma is the most common benign tumor of the liver. An accurate diagnosis of such tumor is essential for proper management of patients with hepatic cavernous hemangioma (HCH). Noninvasive diagnosis of HCH can be made using sequential Tc-99m RBC scintigraphy by demonstrating a perfusion-blood pool mismatch. In addition, a case of HCH was observed which demonstrated peripheral enhancement with subsequent central enhancement on a sequential Tc-99m RBC blood pool scintigraphy. It is felt that this scintigraphic finding is pathognomonic for HCH.

Kim, S.M.; Park, C.H.; Yang, S.L.; Rosato, F.

1987-01-01

17

A giant compound hemangioma of lower lip  

PubMed Central

Hemangioma is one of the most common benign tumors of vascular origin affecting 10–12% of infancy. Approximately 50% of hemangiomas resolve by the age of 5 years and 90% resolve by 9 years of age. Rarely hemangiomas may persist, warranting systemic or surgical treatment. Treatment depends on size, location, and evolution stage of the lesion. In this study, we present a case of huge hemangioma involving lower lip in a 20-year-old male for whom early treatment was ignored due to poor economic status, which was recognized and treated in our institution.

Jeddy, Nadeem; Duraiyan, Jeya Pradha; Palanivelu, Shivakumar; Ramamoorthy, Ananthalakshmi

2012-01-01

18

Spontaneous rupture of hepatic hemangiomas: A review of the literature  

PubMed Central

Hepatic hemangiomas are congenital vascular malformations, considered the most common benign mesenchymal hepatic tumors, composed of masses of blood vessels that are atypical or irregular in arrangement and size. Hepatic hemangiomas can be divided into two major groups: capillary hemangiomas and cavernous hemangiomas These tumors most frequently affect females (80%) and adults in their fourth and fifth decades of life. Most cases are asymptomatic although a few patients may present with a wide variety of clinical symptoms, with spontaneous or traumatic rupture being the most severe complication. In cases of spontaneous rupture, clinical manifestations consist of sudden abdominal pain, and anemia secondary to a haemoperitoneum. Disseminated intravascular coagulopathy can also occur. Haemodynamic instability and signs of hypovolemic shock appear in about one third of cases. As the size of the hemangioma increases, so does the chance of rupture. Imaging studies used in the diagnosis of hepatic hemangiomas include ultrasonography, dynamic contrast-enchanced computed tomography scanning, magnetic resonance imaging, hepatic arteriography, digital subtraction angiography, and nuclear medicine studies. In most cases hepatic hemangiomas are asymptomatic and should be followed up by means of periodic radiological examination. Surgery should be restricted to specific situations. Absolute indications for surgery are spontaneous or traumatic rupture with hemoperitoneum, intratumoral bleeding and consumptive coagulopathy (Kassabach-Merrit syndrome). In a patient presenting with acute abdominal pain due to unknown abdominal disease, spontaneous rupture of a hepatic tumor such as a hemangioma should be considered as a rare differential diagnosis.

Jr, Marcelo AF Ribeiro; Papaiordanou, Francine; Goncalves, Juliana M; Chaib, Eleazar

2010-01-01

19

Radiological evaluation of hepatic cavernous hemangioma  

SciTech Connect

Cavernous hemangiomas of the liver are sufficiently common that they will often be incidentally discovered during hepatic imaging by ultrasound, computed tomography, or radiocolloid scintigraphy. The differentiation of these benign tumors from primary or metastatic hepatic malignancy is mandatory, but often it is not possible on the study in which the lesion was originally detected. There are several routes by which to arrive at the correct diagnosis, but the optimum study or sequence of studies may elude the physician caring for the patient. Knowledge of the imaging options, and the strengths and weaknesses of each of these options, will facilitate a rapid diagnosis and ensure proper treatment, with maximum patient safety and minimum expenditure of resources. This article examines these radiological options.

Brant, W.E.; Floyd, J.L.; Jackson, D.E.; Gilliland, J.D.

1987-05-08

20

Giant cavernous hemangiomas: Diagnosis and surgical strategies  

Microsoft Academic Search

From January, 1972 to June, 1989, 51 patients with liver hemangiomas (32 females and 19 males, mean age 35 years) were evaluated for surgical treatment. Diameters of the masses were 5 cm to 20 cm (median 8.5 cm). Nine of the patients had already been treated for cancer. Twenty-two (43.1%) of the 51 patients were symptomatic and 29 (56.9%) patients

Mario Lise; Gianpietro Feltrin; Pier Paolo Da Pian; Diego Miotto; Pier Luigi Pilati; Leopoldo Rubaltelli; Donatella Zane

1992-01-01

21

Giant Hemangioma Presenting as a Scalp Mass Leading to a Craniofacial Deformity  

Microsoft Academic Search

Hemangioma is the most common vascular tumor during childhood. However, cases of giant hemangiomas determining deformities\\u000a in the craniofacial region are not reported frequently. Craniofacial giant hemangiomas are challenging for surgeons since\\u000a they cause aesthetic and\\/or functional problems and may be associated with important complications such as ulcerations, infections\\u000a and bleedings. The present report is aimed at describing a rare

Rafael Denadai Pigozzi Silva; José Edson da Silva Cavalcante; Eduardo Queiroz Miranda; Dionísio Figueiredo Lopes; Luís Ricardo Martinhão Souto

22

Ultrasonography guided percutaneous radiofrequency ablation for hepatic cavernous hemangioma  

Microsoft Academic Search

AIM: Hepatic cavernous hemangioma (HCH) is the most common benign tumor of the liver and its management is still controversial. Recent success in situ radiofrequency ablation of hepatic malignancies has led us to consider using this technique in patients with HCH. This study was to assess the efficacy, safety, and complications of percutaneous radiofrequency ablation (PRFA) under ultrasonography guidance in

Yan Cui; Li-Yan Zhou; Man-Ku Dong; Ping Wang; Min Ji; Xiao-Ou Li; Chang-Wei Chen; Zi-Pei Liu; Yong-Jie Xu; Hong-Wen Zhang

2003-01-01

23

Concurrent hepatic adenomatoid tumor and hepatic hemangioma: a case report  

PubMed Central

A 45-year-old male with alleged asymptomatic hepatic hemangioma of 4 years duration had right upper-quadrant pain and was referred to a tertiary hospital. Computed tomography and magnetic resonance imaging scans revealed a hypervascular mass of about 7 cm containing intratumoral multilobulated cysts. A preoperative liver biopsy was performed, but this failed to provide a definitive diagnosis. The patient underwent a partial hepatectomy of segments IV and VIII. The histologic findings revealed multifocal proliferation of flattened or cuboidal epithelioid cells and a highly vascular edematous stroma. Immunohistochemistry findings demonstrated that the epithelioid tumor cells were positive for cytokeratin (AE1/AE3), vimentin, calretinin, and cytokeratin 5/6, and were focally positive for CD10, and negative for WT1 and CD34, all of which support their mesothelial origin. Immunohistochemistry for a mesothelial marker should be performed for determining the presence of an adenomatoid tumor when benign epithelioid cells are seen.

Kim, Ji-Beom; Shim, Ju-Hyun; Song, Gi-Won; Kim, Gwang Un; Jin, Young-Joo; Park, Ho-Seop

2012-01-01

24

Planar and SPECT Tc99m red blood cell imaging in hepatic cavernous hemangiomas and other hepatic lesions  

Microsoft Academic Search

The utility of Tc-99m RBC imaging in the diagnosis of hepatic cavernous hemangiomas has been established. Of the 25 patients with various focal hepatic lesions evaluated, 16 were diagnosed as having hemangiomas: eight proven by surgery, two proven by angiography, and six proven by maintaining a stable clinical course ranging from 6 to 12 months with normal follow-up liver function

CHARLES INTENZO; SUNG KIM; MARK MADSEN; ANIL DESAI; CHAN PARK

1988-01-01

25

An atypical case of hepatic cavernous hemangioma  

PubMed Central

Introduction The case of an atypical hepatic angiocavernoma is referred. The lesion, first described as a hypoechogenic area compared to the surrounding parenchyma, with anechogenic shoots inside, suggestive for vascular structures developed one year later into a totally asonic area with frayed margins. This change is very unusual and uncommon for this kind of lesions. Case presentation The case of a 74-year old caucasian male, complaining of slight dyspeptic symptoms (post-prandial fullness and bloating) is referred. The routine blood tests were all normal. Abdominal ultrasound showed a large, roughly round-shaped lesion (diameter 14 cm) in the VIII hepatic segment diagnosed as hepatic angiocavernoma, which turned unexpectedly in a cystic like lesion one year later. Conclusion The atypical angioma's degeneration could account for one of the causes of the patient's exitus. It could be related to blood seizure by the large hepatic angioma due to the intratumoural haemorrhage.

2009-01-01

26

[A case of giant cavernous hemangioma of the nasal septum].  

PubMed

To report a case of an adult male with a huge cavernous hemangioma arising from the nasal septum, and the lesion was widely spread to hard palate, sphenoid sinus, ethmoid sinus and right maxillary sinus. After giving embolization, it was completely excised via transnasal endoscopic approach and lateral rhinotomy, histologic examination reported cavernous hemangioma. There was no recurrence at 1 year's follow-up. PMID:24800551

Ma, Huijuan; Ba, Yunpeng; Su, Hongxia

2014-02-01

27

Laparoscopic resection of giant liver hemangioma using laparoscopic Habib probe for parenchymal transection  

PubMed Central

Experience with laparoscopic liver resections is limited. Laparoscopic resection of a variety of liver lesions has been reported and is considered appropriate for lesions in the left lateral segment and inferior segments of the right lobe. Herein, we report a 52-year-old male patient who underwent a laparoscopic resection of giant liver hemangioma with the use of a laparoscopic 4× Habib probe.

Gadiyaram, Srikanth; Shetty, Neel

2012-01-01

28

[Therapeutical effectiveness of interferon alpha in a child with craniofacial giant hemangioma: case report].  

PubMed

Hemangiomas are the most common benign tumors of infancy. Capillary hemangioma generally is presented as a spot or well-defined purple lesion. The diagnosis of these tumors is based on physical examination. Giant hemangioma is a rare and extensive variation of capillary hemangioma, that generally occurs in newborns and suckling infants. There are several therapeutical modalities, as the intralesional injection of steroids, laser therapy, intralesional injection of sclerosing solutions, surgery, radiotherapy and embolization. New therapeutical modalities have been developed, with the objective of getting better results and to make possible the treatment of the lesions of difficult surgical access or refractory cases to the used therapeutical modalities. The best results have been observed with interferon-alpha. This is a case of a patient with three months of age, that presented since birth, a purplish tumor in the superior eyelid of the right eye, plain and purplish cutaneous lesions in the temporal and parietal right region. On computed tomography of the skull, an orbital expansive vascularized process with intracranial extension could be observed. Systemic therapy with steroids was the initial treatment, during forty days, with gradual reduction for four weeks. With the practically unchanged clinical findings, the treatment with interferon-alpha was indicated, in the dose of subcutaneous 3.000.000 U/m(2), three times a week. After 9 months of treatment, a small residual orbital lesion was observed. In this case, interferon-alpha is presented as a good option for the treatment of craniofacial giant hemangioma. PMID:18641835

Fonseca Junior, Nilson Lopes da; Cha, Sung Bok; Cartum, Jairo; Rehder, José Ricardo Carvalho Lima

2008-01-01

29

Hemangiomas  

MedlinePLUS

... mostly not seen at birth, but start in infancy and then begin to grow. Hemangiomas first appear ... with extreme caution. Spastic dysplegia can cause delayed walking or other problems with walking. Plastic surgery is ...

30

Kupffer-phase findings of hepatic hemangiomas in contrast-enhanced ultrasound with sonazoid.  

PubMed

The aim of this study was to assess quantitatively the Kupffer-phase enhancement patterns of hepatic hemangiomas in contrast-enhanced ultrasound (CEUS) with Sonazoid. A total of 46 patients with 46 hepatic hemangiomas (17.1 ± 6.2 mm in diameter, 34 typical type and 12 high-flow type) underwent CEUS in the Kupffer phase. The lesion-to-liver contrast ratio in the Kupffer phase was quantitatively assessed for both types of hemangioma. Most of the hepatic hemangiomas, whether or not they were the high-flow type, were iso- to hypo-echoic relative to the surrounding liver parenchyma. The contrast ratio was -5.33 ± 6.70 dB for the high-flow hemangiomas and -4.54 ± 6.28 dB for the typical hemangiomas. There was no significant difference in contrast ratio between the two types of lesions (p = 0.73). All of the hemangiomas, whether of typical or high-flow type, are iso- to hypo-echoic relative to the surrounding liver parenchyma on Kupffer-phase imaging. PMID:24556559

Sugimoto, Katsutoshi; Moriyasu, Fuminori; Saito, Kazuhiro; Yoshiara, Hiroki; Imai, Yasuharu

2014-06-01

31

Laparoscopic resection of giant liver hemangioma using laparoscopic Habib probe for parenchymal transection.  

PubMed

Experience with laparoscopic liver resections is limited. Laparoscopic resection of a variety of liver lesions has been reported and is considered appropriate for lesions in the left lateral segment and inferior segments of the right lobe. Herein, we report a 52-year-old male patient who underwent a laparoscopic resection of giant liver hemangioma with the use of a laparoscopic 4× Habib probe. PMID:22623829

Gadiyaram, Srikanth; Shetty, Neel

2012-04-01

32

Acoustic Radiation Force Impulse Elastography for Focal Hepatic Tumors: Usefulness for Differentiating Hemangiomas from Malignant Tumors  

PubMed Central

Objective The purpose of this study is to investigate whether acoustic radiation force impulse (ARFI) elastography with ARFI quantification and ARFI 2-dimensional (2D) imaging is useful for differentiating hepatic hemangiomas from malignant hepatic tumors. Materials and Methods One-hundred-and-one tumors in 74 patients were included in this study: 28 hemangiomas, 26 hepatocellular carcinomas (HCCs), three cholangiocarcinomas (CCCs), 20 colon cancer metastases and 24 other metastases. B-mode ultrasound, ARFI 2D imaging, and ARFI quantification were performed in all tumors. Shear wave velocities (SWVs) of the tumors and the adjacent liver and their SWV differences were compared among the tumor groups. The ARFI 2D images were compared with B-mode images regarding the stiffness, conspicuity and size of the tumors. Results The mean SWV of the hemangiomas was significantly lower than the malignant hepatic tumor groups: hemangiomas, 1.80 ± 0.57 m/sec; HCCs, 2.66 ± 0.94 m/sec; CCCs, 3.27 ± 0.64 m/sec; colon cancer metastases, 3.70 ± 0.61 m/sec; and other metastases, 2.82 ± 0.96 m/sec (p < 0.05). The area under the receiver operating characteristics curve of SWV for differentiating hemangiomas from malignant tumors was 0.86, with a sensitivity of 96.4% and a specificity of 65.8% at a cut-off value of 2.73 m/sec (p < 0.05). In the ARFI 2D images, the malignant tumors except HCCs were stiffer and more conspicuous as compared with the hemangiomas (p < 0.05). Conclusion ARFI elastography with ARFI quantification and ARFI 2D imaging may be useful for differentiating hepatic hemangiomas from malignant hepatic tumors.

Kim, Ji Eun; Bae, Kyung Soo; Han, Joon Koo; Choi, Byung Ihn

2013-01-01

33

[Anesthetic management of a patient with Sturge-Weber syndrome associated with a giant facial hemangioma].  

PubMed

A 32-year old man with Sturge-Weber syndrome, a rare congenital disease of multiple angiomatous lesions including cervical cortex, face, oral soft tissues, larynx and trachea, underwent the excision of a back lipoma. His hemangioma which extended into the region of the right ophthalmic nerve and superior maxillary nerve is extremely large. He also had mental retardation and epilepsy. No apparent hemangioma was found in his oral cavity, pharynxes, larynx and trachea by preoperative exam. His hemangioma made it difficult to cover his mouth and nose by usual face mask. Though we first considered awake intubation, he was difficult to obey our command. So we searched for the face mask covering his nose and mouth without pressing his facial angioma. Finally, we discovered the full-face mask for NIPPV. After induction with propofol, we confirmed the perfect mask fit, and ventilation by two-person method was effective. Then we administered rocuronium and fentanyl, and intubated without difficulty. The patient was maintained by sevoflurane. He was hemodynamically stable. He was extubated without bleeding and respiratory problems. We experienced general anesthesia of a patient with Sturge-Weber syndrome who had a giant facial hemangioma. With full-face NIPPV mask we safely induced general anesthesia. PMID:24979867

Fujii, Noriko; Usuda, Iwao; Hikawa, Yoshio

2014-06-01

34

What is changing in indications and treatment of hepatic hemangiomas. A review.  

PubMed

Hepatic cavernous hemangioma accounts for 73% of all benign liver tumors with a frequency of 0.4-7.3% at autopsy and is the second most common tumor seen in the liver after metastases. Patients affected by hemangioma usually have their tumor diagnosed by ultrasound abdominal examination for a not well defined pain, but pain persist after treatment of the hemangioma. The causes of pain can be various gastrointestinal pathologies including cholelithiasis and peptic ulcer disease.The malignant trasformation is practically inexistent. Different imaging modalities are used to diagnosis liver hemangioma including ultrasonography, computed tomography (CT), magnetic resonance (MR) imaging, and less frequently scintigraphy, positronemission tomography combined with CT (PET/CT) and angiography. Imaging-guided biopsy of hemangioma is usually not resorted to except in extremely atypical cases. The right indications for surgery remain rupture, intratumoral bleeding, Kasabach-Merritt syndrome and organ or vessels compression (gastric outlet obstruction, Budd-Chiari syndrome, etc.) represents the valid indication for surgery and at the same time they are all complications of the tumor itself. The size of the tumor do not represent a valid indication for treatment. Liver hemangiomas, when indication exist, have to be treated firstly by surgery (hepatic resection or enucleation, open, laproscopic or robotic), but in the recent years other therapies like liver transplantation, radiofrequency ablation, radiotherapy, trans-arterial embolization, and chemotherapy have been applied. PMID:24927603

Toro, Adriana; Mahfouz, Ahmed-Emad; Ardiri, Annalisa; Malaguarnera, Michele; Malaguarnera, Giulia; Loria, Francesco; Bertino, Gaetano; Di Carlo, Isidoro

2014-01-01

35

Hepatic hemangioma with normal angiograms: Three case reports  

SciTech Connect

Three cases of symptomatic cavernous hemangioma of the liver are reported. All three patients have normal angiograms. A review of the literature shows that the diagnosis of hemangioma may be made noninvasively with a high degree of accuracy. Technetium Tc 99m-labeled red blood cell scanning is very specific, while dynamic computed tomography may be more sensitive for small lesions. A combination of the two modalities makes the diagnosis in greater than 90% of cases. Magnetic resonance imaging is also sensitive and specific. Angiography, as shown in these cases, may not only be questionably indicated, but may be misleading. The treatment for symptomatic lesions is resection, and secondary alternatives are discussed.

Davis, W.D.; Ferrante, W.A.; Tutton, R.H.; Bowen, J.C. (Ochsner Clinic and Alton Ochsner Medical Foundation, New Orleans, LA (USA))

1990-02-16

36

Interventional Treatment of a Symptomatic Neonatal Hepatic Cavernous Hemangioma Using the Amplatzer Vascular Plug  

SciTech Connect

Percutaneous intervention is one treatment option for symptomatic hepatic hemangioma in infants. We report the case of a newborn (birth weight 4060 g) with a large hepatic cavernous hemangioma, which presented early with high cardiac output failure due to arteriovenous shunting and signs of incipient Kasabach-Merritt syndrome. We performed a successful superselective transcatheter coil embolization of three feeding arteries on the seventh day of life. Because of remaining diffuse very small arteries causing a relevant residual shunt, additional occlusion of the three main draining veins was necessary with three Amplatzer vascular plugs. Cardiac failure resolved immediately. Without any additional therapy the large venous cavities disappeared within the following months. The tumor continues to regress in size 8 months after the intervention.

Kretschmar, Oliver, E-mail: oliver.kretschmar@kispi.unizh.ch; Knirsch, Walter [University Children's Hospital Zurich, Division of Pediatric Cardiology (Switzerland); Bernet, Vera [University Children's Hospital Zurich, Division of Neonatology and Pediatric Intensive Care (Switzerland)

2008-03-15

37

Postinfantile Giant Cell Hepatitis: An Etiological and Prognostic Perspective  

PubMed Central

Giant cell hepatitis is common manifestation in pediatric liver diseases, but quite uncommon in adults, only about 100 cases reported in the English literature in the last two decades. Data for the present review were identified by a structured PubMed/MEDLINE search from 1963 to December 2012, using keywords postinfantile giant cell hepatitis (PIGCH), adult giant cell hepatitis, and syncytial giant cell hepatitis in adults and liver. We report a case of postinfantile giant cell hepatitis along with the review related to the etiology and respective outcome, as the literature in the last 20 years suggests. This condition is probably due to idiosyncratic or cytopathic response of individual to various hepatocytic stimuli. It is purely a histomorphological diagnosis and does not establish the etiology. Autoimmune liver diseases are most common etiology, in around 40% of cases, but various viruses, drugs, posttransplant condition, and other causes also have been reported. Prognosis depends upon the etiology. In this paper, we emphasized various causative factors of PIGCH and their respective outcome in patients affected by them. We also highlighted the possible pathogenesis and histopathological spectrum of this entity on the basis of description given in various studies and our limited experience of few cases.

Bihari, Chhagan; Rastogi, Archana; Sarin, Shiv Kumar

2013-01-01

38

Update on infantile hemangiomas.  

PubMed

Infantile hemangiomas are the most common tumors of infancy. The serendipitous discovery of the therapeutic efficacy of propranolol in the management of infantile hemangiomas has revolutionized the care and understanding of these lesions, and greatly improved the prognosis for a good cosmetic outcome. In addition, there has been an expansion of indications for treatment of hemangiomas, taking into account not only those hemangiomas that can cause airway compromise, amblyopia, and cardiac overload, but also those lesions that can lead to unsatisfactory cosmetic outcome or deformity after involution. Current concepts of pathogenesis of infantile hemangiomas, of segmental hemangiomas with systemic associations, of hepatic hemangiomas, and of the use of systemic and topical beta-blockers for the management of IH are all reviewed. PMID:23419763

Lee, Kachiu C; Bercovitch, Lionel

2013-02-01

39

Post-infantile giant cell hepatitis in patients with primary sclerosing cholangitis and autoimmune hepatitis.  

PubMed

In post-infancy, multinucleated giant cell hepatitis is rare. Various conditions and diseases associated with post-infantile giant cell hepatitis have been described, but the pathogenesis remains unknown. In this paper we review the case reports of four patients (3 male, 1 female; aged 22 to 32 years) with primary sclerosing cholangitis and autoimmune hepatitis. The follow-up ranges from five to seven years. All patients showed cholestasis and repeated elevation of hepatic transaminases. Patients with viral infections, metabolic disorders and toxic influences were excluded. Histopathology of liver tissue in all four patients revealed giant cell formation with up to 20 nuclei in 20-70% of all hepatocytes. Post-infantile giant cell hepatitis was defined histopathologically. The clinical course of all four patients markedly improved after immunosuppressive treatment. Further improvement was observed with the addition of ursodeoxycholic acid. Follow-up liver biopsies during treatment showed reduced inflammation and a decreased number of giant cells. One patient, who initially was admitted to the hospital with liver cirrhosis died five years later due to a sepsis. The clinical course of the other three patients remained stable during the observation period, and no progression of liver fibrosis was recorded as long as immunosuppressive treatment was continued. Cholestasis and autoimmunity seem to be two important mechanisms triggering hepatic giant cell formation in post-infancy. In the reported cases long-lasting cholestasis in primary sclerosing cholangitis together with features of autoimmune hepatitis seem to have triggered the formation of syncytial hepatic giant cells. PMID:8878001

Protzer, U; Dienes, H P; Bianchi, L; Lohse, A W; Helmreich-Becker, I; Gerken, G; Meyer zum Büschenfelde, K H

1996-08-01

40

Capillary Hemangioma  

MedlinePLUS

... Conditions Frequently Asked Questions Español Condiciones Chinese Conditions Capillary Hemangioma En Español Read in Chinese What is a capillary hemangioma? A capillary hemangioma (“strawberry” birthmark) is a ...

41

Hemangioma cavernoso gigante de seno maxilar. Reporte de un caso y revisión de la literatura Giant cavernous hemangioma of the maxillary sinus. Case report and literature review  

Microsoft Academic Search

RESUMEN Los hemangiomas son neoplasias vasculares benignas que se presentan de preferencia en la región cervicofacial, siendo raros en las fosas nasales y excepcionales en los senos paranasales, con pocos casos reportados. Se presenta un paciente de sexo masculino y 33 años de edad, que consultó por obstrucción nasal, aumento de volumen maxilar y exoftalmo izquierdo de 2 años de

Alfredo Naser G; Arturo Samith M; Carlos Ríos D

42

Human papillomavirus (HPV)-associated neonatal giant cell hepatitis (NGCH).  

PubMed

Neonatal giant cell hepatitis (NGCH) is a clinicopathological syndrome that has been related to perinatal infections and metabolic disorders. In a great number of cases no apparent etiology has been found. To characterize the possible relationship between human papillomavirus (HPV) and idiopathic NGCH (INGCH) we analyzed paraffin-embedded hepatic biopsies from seven cases of INGCH for the presence of both HPV and cytomegalovirus (CMV) DNA. Clinically, jaundice, detected within the first 3 days of life (except in one case), and raised levels of serum transaminases and bilirubin, mainly the direct fraction, were recorded in all. Follow-up of six patients revealed complete recovery. In a "blind" experiment, samples were studied along with appropriate controls [2 cases of CMV hepatitis, one case of postinfantile GCH, 12 cases of juvenile laryngeal papillomatosis (JLP), and 5 normal neonatal liver samples] by polymerase chain reaction (PCR). All DNA samples from INGCH consistently showed positive HPV DNA amplification. This was also found in the samples from postinfantile GCH and JLP. In addition, a second biopsy performed 11 months later in one of the cases of INGCH revealed scattered multinucleated hepatocytes and was still positive for HPV DNA. CMV-DNA was detected only in the cases of CMV hepatitis. All five normal livers were negative for HPV and CMV-DNA. These data seem to indicate that HPV may be closely related to a subset of "idiopathic" NGCH with good outcome. PMID:9025842

Drut, R; Gómez, M A; Drut, R M; Lojo, M M

1996-01-01

43

Giant Hepatic Cyst with Septal Structure: Diagnosis and Management  

PubMed Central

The hepatic cyst is a common benign liver tumor, and no surgical treatment is necessary. However, it is difficult to correctly diagnose the giant hepatic cyst containing the solid septal structures inside, from the malignant cystadenocarcinomas. The various imaging modalities such as computed tomography, magnetic resonance imaging, and ultrasonography, have been developed and are useful for the diagnosis of these liver tumors. Reviewing the other reports in this paper, the combination of more than 2 modalities will help to diagnose these tumors; however, the malignant potential is unable to be excluded if the tumor is huge. Therefore, the surgical resection should be considered for the huge hepatic cysts with septal structures if the correct diagnosis is unable to be made. For example, when the hemorrhages cause the granulation in the septa which often shows neovascularization, the imaging modalities are unable to define this situation from the malignant tissue with hypervascularity. Therefore, with the careful review of other reports, we conclude that if the imaging studies show the possible malignant potential or the sizing-up is marked, the surgical treatment should be considered with the consent from the patients.

Sato, Toshihiro; Imai, Michitaka; Hayashi, Kazunao; Isokawa, Osamu; Nomura, Tatsuya; Tsuchiya, Yoshiaki

2013-01-01

44

Prenatal diagnosis of a liver cavernous hemangioma.  

PubMed

Liver tumors seldom occur in the perinatal period. Hepatic hemangiomas are the most common tumors of the liver diagnosed during fetal and neonatal life. The diagnosis can be suspected antenatally by ultrasound and MR scan. The differential diagnosis is often challenging. While small hepatic hemangiomas are usually asymptomatic, large tumors can lead to complications such as high-output congestive heart failure, consumptive thrombocytopenic coagulopathy and hemorrhage after tumor rupture. We describe a case of hepatic hemangioma presenting as a solid abdominal mass with several cystic areas on an obstetric ultrasound and report on the contribition fetal MR imaging to the diagnosis. PMID:23421545

Aslan, Halil; Dural, Ozlem; Yildirim, Gokhan; Acar, Deniz K

2013-10-01

45

Hobnail hemangioma.  

PubMed

We present a case of a 73-year-old woman who developed a small lesion on her tongue. The nodule was resected and hobnail hemangioma was diagnosed. Hobnail hemangioma is a rare vascular lesion with unusual morphology, including bland cells with hobnail appearance, biphasic grow pattern with superficial dilated vessels and slit-like vessels in the deeper portion of the lesion. The infiltrative pattern of grow may cause misdiagnosis. The differential diagnosis with hemangioendothelioma variants, low grade angiosarcomas and Kaposi sarcoma is of particular concern. The lack of recognition of this uncommon entity may result in excessive and unnecessary treatment. PMID:22864784

Hejnold, Maria; Dyduch, Grzegorz; Mojsa, Izabela; Oko?, Krzysztof

2012-06-01

46

Unusual Severe Complication Following Transarterial Chemoembolization for Metastatic Malignant Melanoma: Giant Intrahepatic Cyst and Fatal Hepatic Failure  

Microsoft Academic Search

We describe a 45-year-old male patient with malignant melanoma who underwent hepatic arterial chemoembolization due to liver metastases. Four months after the procedure, the patient developed a giant cystic cavity in the liver. Cytologic examination of the cystic fluid retention revealed necrotic tumor material. The fluid was drained by percutaneous catheter, but the patient developed hepatic failure. This case represents

Selmin Ataergin; Mustafa Tasar; Luis Solchaga; Ahmet Ozet; Fikret Arpaci

2009-01-01

47

Unusual Severe Complication Following Transarterial Chemoembolization for Metastatic Malignant Melanoma: Giant Intrahepatic Cyst and Fatal Hepatic Failure  

Microsoft Academic Search

We describe a 45-year-old male patient with malignant melanoma who underwent hepatic arterial chemoembolization due to liver\\u000a metastases. Four months after the procedure, the patient developed a giant cystic cavity in the liver. Cytologic examination\\u000a of the cystic fluid retention revealed necrotic tumor material. The fluid was drained by percutaneous catheter, but the patient\\u000a developed hepatic failure. This case represents

Selmin Ataergin; Mustafa Tasar; Luis Solchaga; Ahmet Ozet; Fikret Arpaci

2009-01-01

48

Syncytial giant cell hepatitis associated with chronic lymphocytic leukemia: a case report  

PubMed Central

Background Syncytial giant cell hepatitis (GCH) is an uncommon and an underreported disease entity. In two previously reported cases of GCH in patients with Chronic Lymphocytic Leukemia (CLL) liver failure ensued. Autoimmune and infective causes have been implicated but its etiology remains unclear. Case Presentation A 60-year-old female with CLL presented with acute hepatitis with negative viral and auto-immune serologies and without any prior toxic exposure. Liver biopsy showed typical histological features of GCH. The patient was successfully treated with corticosteroids and intravenous immunoglobulin (IVIG). Her liver enzymes returned to baseline and have remained normal as of the last follow up almost 4 years later. Conclusions Association of GCH with CLL may be under recognized. Clinical suspicion of GCH in CLL patients with serology-negative hepatitis, early liver biopsy and therapeutic intervention may influence outcome. This is the first case report of successful treatment of GCH in CLL patients. Moreover, our case also demonstrates the ability to resume effective CLL therapy post-GCH diagnosis without detriment to the liver.

2012-01-01

49

Giant cell hepatitis with autoimmune hemolytic anemia in a nine month old infant  

PubMed Central

Giant cell hepatitis (GCH) with autoimmune hemolytic anemia is a rare entity, limited to young children, with an unknown pathogenesis. We report the case of 9-mo old who presented with fever, diarrhea and jaundice four days before hospitalization. Physical examination found pallor, jaundice and hepatosplenomegaly. The laboratory workup showed serum total bilirubin at 101 ?mol/L, conjugated bilirubin at 84 ?mol/L, hemolytic anemia, thrombocytopenia and immunoglobulin G (IgG) and anti-C3d positive direct Coombs’ test. The antinuclear, anti-smooth muscle and liver kidney microsomes 1 non-organ specific autoantibodies, antiendomisium antibodies were negative. Serological assays for viral hepatitis B and C, cytomegalovirus, herpes simplex and Epstein Barr virus were negative. The association of acute liver failure, Evan’s syndrome, positive direct Coomb’s test of mixed type (IgG and C3) and the absence of organ and non-organ specific autoantibodies suggested the diagnosis of GCH. The diagnosis was confirmed by a needle liver biopsy. The patient was treated by corticosteroids, immunomodulatory therapy and azathioprine but died with septicemia.

Bouguila, Jihene; Mabrouk, Sameh; Tilouche, Samia; Bakir, Dajla; Trabelsi, Amel; Hmila, Amel; Boughammoura, Lamia

2013-01-01

50

Kasabach-Merrit syndrome and adult hepatic epithelioid hemangioendothelioma an unusual association.  

PubMed

Kasabach-Merrit syndrome (KMS) is very rarely observed in adults associated with visceral hemangiomas. Hepatic epithelioid hemangioendothelioma (HEHE) is a very rare clinical entity with an intermediate malignant potential and a mortality rate of 20-30%. We described a case of KMS associated with HEHE in a 70 year old male patient who presented coagulation abnormalities, low platelet count and high fibrin degradation products that were typical features of KMS. Histopathology of the hepatic tissue and a positive immunostaining for endothelial markers confirmed the diagnosis of an HEHE. The first description of KMS was made in children in 1940. It was described as a "consumptive coagulopathy with capillary hemangiomas". However, recent reports have shown that this condition could be associated with kaposiform hemangioendotheliomas, an aggressive form of giant hemangioma. A giant hemangioma in adults as well as an hemangioendothelioma in children could be associated KMS, but an HEHE has been rarely reported in association with this syndrome in adult patients. PMID:15664259

Frider, Bernardo; Bruno, Andrés; Selser, Julio; Vanesa, Rodríguez; Pascual, Pablo; Bistoletti, Raquel

2005-02-01

51

Diagnosis and management of cavernous hemangioma of the liver  

SciTech Connect

Cavernous hemangiomas are the most common benign tumors of the liver, which are now seen more often thanks to common use of newer imaging techniques. A review of the literature on cavernous hemangiomas of the liver, including the author's experience with 14 cases, provides data as a touchstone for discussion of the incidence, etiology, symptoms, pathology, diagnosis including ultrasound, radionuclide imaging, computed tomography and angiography, management including resection, hepatic artery ligation, radiation and corticosteroid, and the natural history of these lesions. The author concludes that surgical resection of cavernous hemangiomas should be undertaken with due concern for the relation between the severity of symptoms and the operative risks involved.

Takagi, H.

1985-01-01

52

A Case of Giant Hepatic Hydatid Cyst Infected with Morganella morganii and the Literature Review  

PubMed Central

Hydatid cyst disease is a common worldwide zoonosis. Most of the cysts are located in the liver. Abscess formation due to infection of the cyst is an important complication. M. morganii, a Gram-negative Bacillus, is a quite rare cause of liver abscess. A 77-year-old woman was admitted to hospital with complaints of fever, chills, nausea, vomiting, loss of appetite, and abdominal pain located in the right-upper quadrant. Her history was positive for hepatic hydatid cyst disease ten years ago. Physical examination revealed a painful mass filling the right-upper quadrant and extending down to umbilicus. Indirect hemagglutinin test for hydatid cyst was positive at a titer of 1/320. Giant liver abscess due to infected hydatid cyst was found in computed tomography scan. Surgeons performed cystectomy and cholecystectomy. Cefazoline, cefuroxime, and metronidazole were administered empirically, but all the three agents were replaced with intravenous ceftriaxone after M. morganii was isolated from the cultures of the abscess material. Clinical signs of the patient resolved at the second week of treatment, and she was discharged.

Hakyemez, Ismail Necati; Sit, Mustafa; Aktas, Gulali; Tas, Tekin; Mengeloglu, F?rat Zafer; Kucukbayrak, Abdulkadir

2012-01-01

53

Hepatic resection for giant haemangioma in a patient with a contemporaneous adult polycystic liver disease.  

PubMed

Hepatic resection for giant haemangioma in a patient with a contemporaneous adult polycystic liver disease. According to Gigot classification, and to the characteristics of haemangioma surgery in these patients can be considered safe. We report the case of a 55 year-old man affected by an adult polycystic liver disease (PCLD) and a contemporaneous symptomatic haemangioma of the III segment. At the preoperative imaging scans, APCLD was classified in a type II grading according to Gigot classification. The patient underwent surgery: a wedge resection of the III segment with the exportation of the haemangioma and a fenestration of a large cyst placed in the VIII segment were performed. Post-operative course was regular and the patient was discharged uneventfully in post-operative 9th day, with a total regress of the initial symptoms. APCLD and haemangioma are two benign conditions that do not require surgery except if they cause important symptoms, such as pain. The good clinical conditions of the patient, the moderate gravity of the APCLD and the particular exofitic localisation of the cavernous haemangioma gave us the possibility to make a safe surgery for the patient. To the best of our knowledge, this is the first case reported in literature in which a liver resection for haemangioma in patient with APCLD was performed. In conclusion, liver resection for haemangioma is not contraindicated, mainly if it is symptomatic, even in the contemporaneous presence of an APCLD. PMID:23099970

Levi Sandri, G B; Lai, Q; Melandro, F; Guglielmo, N; Garofalo, M; Morabito, V; Cirelli, C; Lucatelli, P; Di Laudo, M; Rossi, M; Berloco, P B

2012-01-01

54

Propranolol for Infantile Hemangiomas  

PubMed Central

Hemangiomas are common vascular birthmarks that usually present a predictable pattern of proliferation and ultimate involution. Most do not require any treatment. When intervention is clinically indicated, medical and surgical options exist. Historically, corticosteroids have been used and have been shown to slow or stop the growth of a majority of hemangiomas; however, growth concerns and infectious complications have complicated their use. In 2008, a letter to the editor in The New England Journal of Medicine described another serendipitous observation of the effect of the nonselective beta-blocker, propranolol, on hemangiomas in 9 cases. This finding has been expanded by the authors of this original observation as well as others.

Levy, Moise L.

2012-01-01

55

Nasal Lobular Capillary Hemangioma  

PubMed Central

Nasal lobular capillary hemangioma is a rare benign tumor of the paranasal sinuses. This lesion is believed to grow rapidly in size over time. The exact etiopathogenesis is still a dilemma. We discuss a case of nasal lobular capillary hemangioma presenting with a history of epistaxis. Contrast enhanced computed tomography of paranasal sinuses revealed an intensely enhancing soft-tissue mass in the left nasal cavity and left middle and inferior meati with no obvious bony remodeling or destruction. We present imaging and pathologic features of nasal lobular capillary hemangioma and differentiate it from other entities like nasal angiofibroma.

Patil, Prashant; Singla, Saurabh; Mane, Ranoji; Jagdeesh, K. S.

2013-01-01

56

Fatal spontaneous subdural bleeding due to neonatal giant cell hepatitis: a rare differential diagnosis of shaken baby syndrome.  

PubMed

A 7-week-old girl showed vomiting after feeding, facial pallor, loss of muscle tone and respiratory depression. An emergency doctor performed successful resuscitation and after arrival in hospital, cranial ultrasound showed left-sided subdural hemorrhage, cerebral edema with a shift of the midline, and a decrease in cerebral perfusion. Ophthalmologic examination showed retinal hemorrhage. In view of this, the doctors suspected shaken baby syndrome and approached the parents with their suspicions, but they denied any shaking or trauma. Despite surgery for the subdural hemorrhage the girl died a few hours later with a severe coagulopathy. Autopsy verified subdural hemorrhage, cerebral edema and retinal hemorrhage, but also revealed intact bridging veins and a lack of optic nerve sheath hemorrhage, therefore shaken baby syndrome could not be proven by autopsy. Histological examination showed severe neonatal giant cell hepatitis as the cause of the severe coagulopathy and the associated spontaneous subdural bleeding. Neonatal giant cell hepatitis may be responsible for unexpected deaths in infancy and, although rarely associated with subdural bleeding, must be considered as a potential differential diagnosis of shaken baby syndrome. PMID:21331818

Guddat, Saskia S; Ehrlich, Edwin; Martin, Hubert; Tsokos, Michael

2011-09-01

57

Excisional treatment of cavernous hemangioma of the liver.  

PubMed Central

Fifteen patients had hepatic hemangiomas removed with liver resections that ranged in extent from local excision to right trisegmentectomy. There was no mortality and little morbidity. The propriety and feasibility of extirpative treatment of such liver tumors has been emphasized by this experience.

Starzl, T E; Koep, L J; Weil, R; Fennell, R H; Iwatsuki, S; Kano, T; Johnson, M L

1980-01-01

58

Periocular hemangiomas and lymphangiomas.  

PubMed

Infantile hemangiomas are the most common benign tumor of childhood. Lymphangiomas are benign hamartomatous vascular tumors. Both lesions can be problematic when located in the periocular region. Pediatricians must be familiar with the characteristics of each which would necessitate referral to an ophthalmologist or other subspecialist for evaluation, including obstruction of the visual axis which can lead to amblyopia of the affected eye. Additional potential complications include proptosis, ocular motility limitation, optic nerve injury, and poor eyelid closure with or without corneal surface disease. All children with periocular hemangiomas or lymphangiomas should be referred to an ophthalmologist for further evaluation. PMID:24852151

Reem, Rachel E; Golden, Richard P

2014-06-01

59

Left ventricular hemangioma.  

PubMed

A young Saudi woman presented with symptoms of palpitation, near syncope, anxiety, and fatigue. Transthoracic echocardiography showed a left ventricular mass. Under cardiopulmonary bypass, brief cardioplegic arrest, and the aid of a thoracoscope, the mass was resected. Histologic examination showed a rare benign cardiac tumor: mixed cavernous-capillary hemangioma. PMID:24585648

Oueida, Farouk M; Lui, Raphael C; Al-Refae, Mustafa A; Al-Omran, Hamed M

2014-01-01

60

Orbital cavernous hemangiomas  

Microsoft Academic Search

Cavernous hemangiomas are the most frequently found primary tumors in the orbital region. They normally appear in adults. Diagnostic features in the majority of cases include protrusio bulbi and orbital enlargement. B-Scan and computed tomography\\/MRI are the prime diagnostic aids. We recommend surgical removal of these tumors, at least in cases with marked orbital protrusion or significant optic nerve compression.

Thomas Herter; Harald Bennefeld; Matthias Brandt

1988-01-01

61

Liver hemangioma and vascular liver diseases in patients with systemic lupus erythematosus  

PubMed Central

AIM: To investigate whether systemic lupus erythematosus (SLE) is associated with benign focal liver lesions and vascular liver diseases, since these have been occasionally reported in SLE patients. METHODS: Thirty-five consecutive adult patients with SLE and 35 age- and sex-matched healthy controls were evaluated. Hepatic and portal vein patency and presence of focal liver lesions were studied by colour-Doppler ultrasound, computerized tomography and magnetic resonance were used to refine the diagnosis, clinical data of SLE patients were reviewed. RESULTS: Benign hepatic lesions were common in SLE patients (54% vs 14% controls, P < 0.0001), with hemangioma being the most commonly observed lesion in the two groups. SLE was associated with the presence of single hemangioma [odds ratios (OR) 5.05; 95% confidence interval (CI) 1.91-13.38] and multiple hemangiomas (OR 4.13; 95% CI 1.03-16.55). Multiple hemangiomas were associated with a longer duration of SLE (9.9 ± 6.5 vs 5.5 ± 6.4 years; P = 0.04). Imaging prior to SLE onset was available in 9 patients with SLE and hemangioma, showing absence of lesions in 7/9. The clinical data of our patients suggest that SLE possibly plays a role in the development of hemangioma. In addition, a Budd-Chiari syndrome associated with nodular regenerative hyperplasia (NRH), and a NRH associated with hepatic hemangioma were observed, both in patients hospitalized for abdominal symptoms, suggesting that vascular liver diseases should be specifically investigated in this population. CONCLUSION: SLE is associated with 5-fold increased odds of liver hemangiomas, suggesting that these might be considered among the hepatic manifestations of SLE.

Berzigotti, Annalisa; Frigato, Marilena; Manfredini, Elena; Pierpaoli, Lucia; Mule, Rita; Tiani, Carolina; Zappoli, Paola; Magalotti, Donatella; Malavolta, Nazzarena; Zoli, Marco

2011-01-01

62

Cardiac Hemangioma: A Case Report  

PubMed Central

Hemangioma of the heart, presenting as a primary cardiac tumor is extremely rare; it accounts for approximately 2% of all primary resected heart tumors. In our patient, the tumor was located in the orifice of the right lower pulmonary vein. Few cases of cardiac hemangiomas have been reported to arise from the left atrial (LA) wall. Left atrial hemangiomas, especially those attached to the LA wall, may be erroneously diagnosed as myxomas. Cardiac hemangioma is a rare disease; furthermore, a tumor arising from the LA wall and misconceived as a myxoma is extremely rare. We removed a mass misdiagnosed as a myxoma; it was pathologically confirmed to be a cardiac capillary hemangioma. Therefore, we report a rare case of a cardiac hemangioma misconceived as a myxoma; the tumor was removed successfully.

Hong, Sung-Yong; Park, Kyung-Taek; Lee, Yang-Haeng; Cho, Kwang-Hyun; Seo, Jeong-Sook

2014-01-01

63

Differential diagnosis of infantile hemangiomas.  

PubMed

1.Compare and contrast infantile hemangiomas with other vascular anomalies that may be confused clinically.2.Describe the vascular anomalies classification system according to the International Society for the Study of Vascular Anomalies (ISSVA), highlighting the differences between vascular tumors, such as infantile hemangiomas, and vascular malformations.3.Briefly review associated signs or syndromes found in the context of certain vascular anomalies.Infantile hemangiomas are the most common benign vascular tumor in infancy but may mimic many other types of vascular anomalies. In many cases, the appearance, time of onset, growth pattern, and consistency of infantile hemangiomas make the diagnosis straightforward (see "Pathogenesis of Infantile Hemangiomas" on p. 321). However, many other vascular lesions can appear quite similar to infantile hemangiomas, especially early in life, and at times this makes the correct diagnosis challenging. PMID:22881414

Perman, Marissa J; Castelo-Soccio, Leslie; Jen, Melinda

2012-08-01

64

Cavernous Hemangioma of the Tongue  

PubMed Central

Hemangioma is a benign tumor of dilated blood vessels. It is most commonly seen in the head and neck region and rarely in the oral cavity. Hemangiomas in the oral cavity are always of clinical importance and require appropriate treatment. We report here a case of a 34-year-old female patient with a swelling on the lateral surface of tongue which did not respond to the sclerosing agent and was finally confirmed as cavernous hemangioma on histological evaluation.

Kripal, Krishna; Rajan, Senthil; Ropak, Beena; Jayanti, Ipsita

2013-01-01

65

Case report: Periorbital intraosseous hemangiomas  

PubMed Central

Hemangiomas are hamartomatous proliferation of vessels. Intraosseous hemangiomas of the facial bones are rare and most commonly involve the zygoma, maxilla, mandible, and the nasal bones. A “sunburst” pattern is a typical appearance on CT scan and MRI and therefore a biopsy is not always necessary. Surgery is usually performed in symptomatic cases. The authors describe five typical periorbital intraosseous hemangiomas with a brief review of literature.

Goncalves, Fabricio Guimaraes; Rojas, Juan Pablo Ovalle; Hanagandi, Prasad Baladev; Valente, Rodolfo; Torres, Carlos Ignacio; Chankwosky, Jeffrey; DelCardio-O'Donovan, Raquel

2011-01-01

66

[Intraosseous cranioorbital hemangiomas].  

PubMed

The authors describe 2 cases of primary intraosseous cavernous hemangioma (PICH). PICH are extremely rare tumors that represent less than 1% of all tumors of the bone. Only 20% of them involve skull. In both cases clinical findings were presented by proptosis, oculomotor disorders and chronic daily headaches. Surgery is the most recommended method of treatment. The best surgical management is gross total resection within intact tissue. In both cases tumor was removed completely. PMID:22066260

Belov, A I; Cherekaev, V A; Shishkina, L V; Lasunin, N V; Kadasheva, A B; Grigor'eva, N N; Podoprigora, A E

2011-01-01

67

[Intraorbital cavernous hemangioma].  

PubMed

Cavernous hemangioma is the most frequent primary vascular orbital tumor in adults. This slowly evolving lesion is usually located behind the ocular globe, between the extrinsic muscles. It leads to axial exophthalmia. Surgical treatment is indicated when there is a risk of visual impairment. The prognosis is related to the size of the lesion and its extension. CT scan is rather unspecific, but MRI is highly sensitive and specific in case of progressive painless exophthalmia. PMID:18707746

Bouguila, J; Yacoub, K; Bouguila, H; Neji, N Ben; Sahtout, S; Besbes, G

2008-11-01

68

Hepatitis  

MedlinePLUS

... if they've been vaccinated against it. Continue Hepatitis B Hepatitis B is a more serious infection. It may lead ... of which cause severe illness and even death. Hepatitis B virus (HBV) is transmitted from person to person ...

69

Hepatitis  

MedlinePLUS

... into the food and water supply. Back Continue Hepatitis B and Hepatitis C Although hep A is a ... does — through direct contact with infected body fluids. Hepatitis B and C are even more easily passed in ...

70

Hobnail hemangioma on the trunk.  

PubMed

Hobnail hemangioma is a rare, benign vascular growth that typically presents in the third and fourth decades of life. It classically presents as a targetoid lesion with a violaceous central papule surrounded by a peripheral ecchymotic rim. Common sites of involvement include extremities and trunk. We present this case of hobnail hemangioma in a 10-year- old boy because of its rarity. PMID:24011279

Krishna, C Vijay; Reddy, G Madhusudhan; Senthil Kumar, A L; Mohan Rao, A Vijaya

2013-01-01

71

Cavernous hemangioma of the rib  

Microsoft Academic Search

A 59-year-old man with an enlarged left chest wall mass that had been followed up for 3 years underwent surgical resection. The mass was pathologically diagnosed as cavernous hemangioma of the rib. This is the fourth case of this rare disease to be reported. However, it suggests that hemangioma of the rib should be considered in the differential diagnosis of

Katsuhiko Shimizu; Yoshinori Yamashita; Jun Hihara; Yoshihiro Seto; Tetsuya Toge

2002-01-01

72

Angiography in intracerebral cavernous hemangioma  

Microsoft Academic Search

Only a few cases with proven cavernous hemangioma have been examined with rapid serial angiography and the subtraction procedure. With the use of this technique a group of angiographic signs can be found which makes it possible to make an accurate diagnosis of a cavernous hemangioma. The angiographical changes are discussed in 3 cases.

B. Liliequist

1975-01-01

73

Tumefactive presentation of a supratentorial cavernous hemangioma: A report of two cases  

PubMed Central

This study reports two children, including a 2-month-old infant, harboring giant cavernous hemangiomas (GCH) in the supratentorial compartment, causing raised intracranial pressure and focal deficits. Relevant demographic details, clinical presentation, and radiological findings of GCH are discussed in light of tumefactive presentation. Differential diagnoses of such radiological findings are elaborated.

Mohindra, Sandeep; Sodhi, Harsimratbir Singh; Rane, Swapnil

2013-01-01

74

Tumefactive presentation of a supratentorial cavernous hemangioma: A report of two cases.  

PubMed

This study reports two children, including a 2-month-old infant, harboring giant cavernous hemangiomas (GCH) in the supratentorial compartment, causing raised intracranial pressure and focal deficits. Relevant demographic details, clinical presentation, and radiological findings of GCH are discussed in light of tumefactive presentation. Differential diagnoses of such radiological findings are elaborated. PMID:24470821

Mohindra, Sandeep; Sodhi, Harsimratbir Singh; Rane, Swapnil

2013-09-01

75

Infantile hemangiomas: A review  

PubMed Central

Infantile hemangiomas (IH) are the most common eyelid and orbital tumors of childhood. Although they are considered benign lesions that have a generally self-limited course, in the periocular region, they have the potential to cause amblyopia, strabismus, and severe disfigurement. The decision for treatment can be a source of anxiety for patients, parents, and physicians alike. There are numerous treatment modalities, including emerging therapies that may make treatment safer and more effective than ever before. This review discusses our current understanding of this disease, its management, and future therapies.

Callahan, Alison B.; Yoon, Michael K.

2012-01-01

76

Giant extra-hepatic thrombosed portal vein aneurysm: a case report and review of the literature  

PubMed Central

Background Extrahepatic Portal vein aneurysm (EPVA) is a rare finding that may be associated with different complications, e.g. thrombosis, rupture, portal hypertension and compression of adjacent structures. It is being diagnosed more frequently with the advent of modern cross-sectional imaging. Our review of the English literature disclosed 13 cases of thrombosed EPVA. Case presentation A 50-years-old woman presented with acute abdominal pain but no other symptom. She had no relevant medical history. Palpation of the right upper quadrant showed tenderness. Laboratory tests were unremarkable. A computed tomography showed portal vein aneurysm measuring 88 × 65 mm with thrombosis extending to the superior mesenteric and splenic vein. The patient was treated conservatively with anticoagulation therapy. She was released after two weeks and followed on an outpatient basis. At two months, she reported decreased abdominal pain and her physical examination was normal. A computed tomography was performed showing a decreased thrombosis size and extent, measuring 80 × 55 mm. Conclusions Although rare, surgeons should be made aware of this entity. Complications are various. Conservative therapy should be chosen in first intent in most cases. We reported the case of the second largest thrombosed extra-hepatic PVA described in the literature, treated by anticoagulation therapy with a good clinical and radiological response.

2014-01-01

77

Chorionic villus sampling and hemangiomas.  

PubMed

Chorionic villus sampling (CVS) is a widely used and safe method of prenatal diagnosis. In the 1990s, concerns were raised at several medical centers that there was an increased risk to the exposed fetus for the occurrence of limb deficiencies, hemangiomas, and other vascular disruption defects. The risk was greater when the procedure was performed earlier in pregnancy, such as 8 or 9 weeks of gestation. The postulated mechanisms for the fetal injury included blood loss, hypoperfusion, hypoxia, endothelial cell damage, hemorrhage, and tissue loss. The effect was most common in tissues with end arteries, such as digits, tongue, brain stem, and intestine. The associated hemangiomas were infantile hemangiomas. They were more common on the head, neck, and thorax and more often multiple in infants exposed to CVS. One postulated mechanism for the occurrence of these hemangiomas is embolization of angioblasts or endothelial cells from the placenta to the fetal skin. A question to be answered is whether the infantile hemangiomas in children exposed to CVS differ in immunohistologic characteristics from similar hemangiomas in children not exposed to CVS during pregnancy. PMID:19218861

Holmes, Lewis B

2009-03-01

78

Imaging characteristics of two subtypes of congenital hemangiomas: rapidly involuting congenital hemangiomas and non-involuting congenital hemangiomas  

Microsoft Academic Search

Background: Common infantile hemangiomas (COMMON) occur in approximately 10% of infants by the age of 1 year, with a female predominance. Some hemangiomas can be fully developed at birth and are thus called congenital hemangiomas (CH). Within this population, two courses have been identified: rapidly involuting CH (RICH) and non-involuting CH (NICH). Little has been reported on the clinical prognosis and

Guillaume Gorincour; Victor Kokta; Francoise Rypens; Laurent Garel; Julie Powell; Josée Dubois

2005-01-01

79

Large orbital hemangioma: managed with systemic propranolol.  

PubMed

Most infantile hemangiomas resolve spontaneously without any need for therapy. However some hemangiomas require treatment to preserve function (vision, feeding and breathing) or to treat complications like ulceration, bleeding and scarring. The authors present a 5-mo-old infant with large orbital hemangioma on left side completely obscuring palpebral fissure, successfully managed with oral propranolol. PMID:24271877

Puligadda, Ranjith K; Vijayalakshmi, B

2014-08-01

80

Hemangioma of the buccal fat pad  

PubMed Central

Hemangiomas are benign vascular neoplasms characterized by an abnormal proliferation of blood vessels. Buccal fat pad (BFP) is a rare place for hemangioma. In this report, clinical, radiographic, and histopathological findings are described in a rare case of hemangioma with phleboliths involving the BFP, and a review is made of the international literature on this subject.

Hassani, Ali; Saadat, Sarang; Moshiri, Roya; Shahmirzadi, Solaleh

2014-01-01

81

An unusual vascular tumor: verrucous hemangioma.  

PubMed

Verrucous hemangioma is an uncommon capillary or cavernous hemangioma with reactive epidermal changes of hyperkeratosis, acanthosis, and papillomatosis. These growths are usually located on the lower extremities and involvement is generally unilateral. A diagnosis of verrucous hemangioma should be considered in lesions especially with a hyperkeratotic nodular appearance located on the lower extremities. PMID:19951643

Koc, Melek; Kavala, Mukaddes; Kocatürk, Emek; Zemheri, Ebru; Zindanci, Ilkin; Sudogan, Sibel; Kural, Esra

2009-01-01

82

Pregnancy related symptomatic vertebral hemangioma.  

PubMed

Vertebral hemangiomas are benign vascular tumors of the spine that remain asymptomatic in most cases and incidentally encountered on imaging. Rarely, altered hemodynamic and hormonal changes during pregnancy may expand these benign lesions resulting in severe cord compression. The management of symptomatic vertebral hemangioma during pregnancy is controversial as modalities like radiotherapy and embolization are not suitable and surgery during pregnancy has a risk of preterm labor. Few cases of pregnancy related symptomatic vertebral hemangioma with marked epidural component have been reported in the literature. We report a case of 23-year-old primigravida who developed rapidly progressive paraparesis at 28 weeks of gestation and spine magnetic resonance imaging (MRI) revealed upper thoracic vertebral hemangioma with extensive extra-osseous extension and spinal cord compression. Laminectomy and surgical decompression of the cord was performed at 32 weeks of the pregnancy. There was significant improvement in muscle power after a week of surgery. Six weeks postoperatively she delivered a full term normal baby with subsequent improvement of neurologic deficit. Repeat MRI of dorsal spine performed at 3 months postoperatively showed reduced posterior and anterior epidural components of vertebral hemangioma. PMID:24753678

Gupta, Meena; Nayak, Rajeev; Singh, Hukum; Khwaja, Geeta; Chowdhury, Debashish

2014-01-01

83

Pregnancy related symptomatic vertebral hemangioma  

PubMed Central

Vertebral hemangiomas are benign vascular tumors of the spine that remain asymptomatic in most cases and incidentally encountered on imaging. Rarely, altered hemodynamic and hormonal changes during pregnancy may expand these benign lesions resulting in severe cord compression. The management of symptomatic vertebral hemangioma during pregnancy is controversial as modalities like radiotherapy and embolization are not suitable and surgery during pregnancy has a risk of preterm labor. Few cases of pregnancy related symptomatic vertebral hemangioma with marked epidural component have been reported in the literature. We report a case of 23-year-old primigravida who developed rapidly progressive paraparesis at 28 weeks of gestation and spine magnetic resonance imaging (MRI) revealed upper thoracic vertebral hemangioma with extensive extra-osseous extension and spinal cord compression. Laminectomy and surgical decompression of the cord was performed at 32 weeks of the pregnancy. There was significant improvement in muscle power after a week of surgery. Six weeks postoperatively she delivered a full term normal baby with subsequent improvement of neurologic deficit. Repeat MRI of dorsal spine performed at 3 months postoperatively showed reduced posterior and anterior epidural components of vertebral hemangioma.

Gupta, Meena; Nayak, Rajeev; Singh, Hukum; Khwaja, Geeta; Chowdhury, Debashish

2014-01-01

84

Congenital and multiple hobnail hemangiomas.  

PubMed

Hobnail hemangioma (targetoid hemosiderotic hemangioma) is a vascular tumor affecting the limbs or trunk. Characteristically, the lesion has a "targetoid" clinical feature and dilated vascular spaces lined by hobnail endothelial cells at histologic examination. The age of onset is widely variable, form 5~67 years, typically occurring in young or middle-aged persons. It is usually apparent as a small solitary lesion. However, multiple lesions are identified sometimes. Herein, we report two cases of hobnail hemangioma in 7-year-old and 15-year-old males. Of note, the former case had a congenital lesion and the latter, multiple acquired lesions, which are both rare atypical presentations of the disease. PMID:22148030

Yoon, So Young; Kwon, Hyuck Hoon; Jeon, Hye Chan; Lee, Jong Hee; Cho, Soyun

2011-11-01

85

Symptomatic vertebral hemangiomas during pregnancy.  

PubMed

Symptomatic vertebral hemangiomas during pregnancy are rare, as only 27 cases have been reported in the literature since 1948. However, symptomatic vertebral hemangiomas can be responsible for spinal cord compression, in which case they constitute a medical emergency, which raises management difficulties in the context of pregnancy. Pregnancy is a known factor responsible for deterioration of these vascular tumors. In this paper, the authors report 2 clinical cases of symptomatic vertebral hemangiomas during pregnancy, including 1 case of spontaneous fracture that has never been previously reported in the literature. The authors then present a brief review of the literature to discuss emergency management of this condition. The first case was a 28-year-old woman at 35 weeks of gestation, who presented with paraparesis. Spinal cord MRI demonstrated a vertebral hemangioma invading the body and posterior arch of T-3 with posterior epidural extension. Laminectomy and vertebroplasty were performed after cesarean section, allowing neurological recovery. The second case involved a 35-year-old woman who presented with spontaneous fracture of T-7 at 36 weeks of gestation, revealing a vertebral hemangioma with no neurological deficit, but it was responsible for pain and local instability. Treatment consisted of postpartum posterior interbody fusion. With a clinical and radiological follow-up of 2 years, no complications and no modification of the hemangiomas were observed. A review of the literature reveals discordant management of these rare cases, which is why the treatment course must be decided by a multidisciplinary team as a function of fetal gestational age and maternal neurological features. PMID:24605997

Moles, Alexis; Hamel, Olivier; Perret, Christophe; Bord, Eric; Robert, Roger; Buffenoir, Kevin

2014-05-01

86

Verrucous Hemangioma: A Clinicopathologic Study of 21 Cases.  

National Technical Information Service (NTIS)

Verrucous hemangioma is a structural variant of capillary or cavernous hemangioma in which reactive epidermal acanthosis, papillomatosis, and hyperkeratosis develop secondarily. The clinical appearance of verrucous hemangioma may simulate that of angioker...

R. Imperial E. B. Helwig

1967-01-01

87

Magnetic resonance imaging of cavernous sinus cavernous hemangiomas  

Microsoft Academic Search

Radiological findings of surgically verified cavernous hemangiomas of the cavernous sinus are presented with special reference to the appearance in magnetic resonance imaging. Differences in radiological features of the cavernous sinus cavernous hemangiomas and intracerebral cavernous hemangiomas are discussed.

Y. Katayama; T. Tsubokawa; S. Miyazaki; K. Yoshida; K. Himi

1991-01-01

88

Capillary hemangioma of the testis.  

PubMed

Testicular hemangiomas are benign vascular neoplasms usually occurring in children. Pathologists must be aware of this entity when performing intraoperative frozen sections as, after diagnosis, testicle-sparing surgery is adequate. The authors present a typical case with immunohistochemical studies and a review of the literature. PMID:19147509

Talmon, Geoffrey A; Stanley, Stephen M; Lager, Donna J

2011-06-01

89

CAVERNOUS HEMANGIOMA OF THE KIDNEY  

Microsoft Academic Search

Three patients with cavernous hemangiomas of the kidney all presented with hematuria. In each there was found a poorly defined renal medullary mass with dis- placement of the calyces and renal vessels and paradoxical hypovascularity of the mass. This rare, benign tumor of the kidney should be considered in the presence of this characteristic clinical picture.

ROBERT J. STANLEY; ENRIQUE CUBILLO; RAUL MANCILLA; GUILLERMO GEISSE; G. LELAND MELSON

90

Hemangioma of the Facial Nerve  

PubMed Central

Hemangioma of the facial nerve may occur more frequently than previously recognized. This benign vascular tumor most often arises in the area of the geniculate ganglion, although the reason for this site of predilection is not known. Using silicon injection and cross-sectional vessel counts, we recently demonstrated the presence of a geniculate capillary plexus (GCP) in the cat. The present study was designed to identify a similar GCP in man, if present, and to relate if to the site of predilection of hemangioma of the facial nerve. Twenty-five human facial nerves were studied in horizontally sectioned temporal bones. A clinical case of hemangioma arising at the geniculate ganglion is presented. The human geniculate ganglion has a very rich capillary plexus in contrast to the poor intrinsic vasculature of the adjacent labyrinthine segment and nioderate vasculature of the tympanic segment of the facial nerve. We hypothesize that the GCP is the origin of most hemangiomas of facial nerve. The anatomic distinctness of the geniculate gangion and GCP from the facial nerve may allow removal of these tumors with preservation of motor function in certain cases. ImagesFigure 1Figure 2Figure 3

Balkany, Thomas; Fradis, Milo; Jafek, Bruce W.; Rucker, Nolan C.

1991-01-01

91

Oral hobnail hemangioma: case report.  

PubMed

Hobnail hemangioma (HH) is a rare benign vascular neoplasm reported as a distinctive small benign, solitary vascular neoplasm of the superficial and mid-dermis occurring on the face, trunk, or extremities of young or middle-aged adults. The oral manifestations are quite uncommon, with only three cases reported in the English language literature. The following case refers to a 38-year-old woman with a small nodule on the hard palatal mucosa. Histological findings showed a biphasic growth pattern of irregularly dilated vascular structures in the superficial mucosa, lined by epithelioid endothelial cells with a hobnail appearance, with neoplastic vessels observed in deeper parts of the lesion. In the oral cavity, the differential diagnosis includes hemangioma, melanoma, and Kaposi's sarcoma, whose clinical and histological features may be confused with those of HH. PMID:20027132

Vieira Cury, S E; Chain Hartung Habibe, R; Siroteau Corrêa Pontes, F; Rebelo Pontes, H A; Santos De Freitas Silva, B; Dos Santos Pinto, Jr D

2009-01-01

92

Isolated cavernous hemangioma of conjunctiva.  

PubMed

A 70-year-old Indian female presented with a lobulated, violet-colored mass in the left eye involving the medial bulbar conjunctiva and caruncle. It was smooth, vascular, compressible, and freely mobile. It was neither reducible nor pulsatile and did not cause any proptosis or dystopia. Any syndromic associations and orbital extension of the lesion were ruled out. Excisional biopsy was performed, and histopathologic examination confirmed the diagnosis of cavernous hemangioma of conjunctiva involving the caruncle. PMID:20639785

Malik, Archana; Bhala, Soniya; Arya, Sudesh K; Narang, Subina; Punia, Rajpal P S; Sood, Sunandan

2010-01-01

93

Anastomosing hemangioma of the kidney: a case report of a rare subtype of hemangioma mimicking angiosarcoma and review of the literature  

PubMed Central

Anastomosing hemangioma is a recently described, unusual variant of capillary hemangioma which seems to be unique for the genitourinary system, with a particular proclivity for the kidney. Histologically, it is characterized by a unique sinusoidal architecture reminiscent of splenic parenchyma that can lead to concern for angiosarcoma. We herein report a further case of anastomosing hemangioma originating in the right kidney of a 48-year-old Chinese man. The patient had a past medical history significant for hepatocellular carcinoma; this tumor was incidentally identified as an asymptomatic right renal mass during the periodical surveillance of the hepatic cancer. The resected tumor measured 2.5cm in maximum diameter and microscopically demonstrated an overall lobulated growth pattern with alternating cellular areas composed of anastomosing sinusoidal capillary-sized vessels lined by hobnail endothelial cells, and edematous, hyaline paucicellular areas. Cytologically the tumor cells were generally bland and exhibited positivity for CD31, CD34 immunohistochemically. The patient had been in a good status without evidence of tumor recurrence 12 months after the surgery. This rare variant renal hemangioma is in need of more recognition and should not be over-diagnosed as a malignance, particularly angiosarcoma.

Zhao, Ming; Li, Changshui; Zheng, Jiangjiang; Sun, Ke

2013-01-01

94

Anastomosing hemangioma of the kidney: a case report of a rare subtype of hemangioma mimicking angiosarcoma and review of the literature.  

PubMed

Anastomosing hemangioma is a recently described, unusual variant of capillary hemangioma which seems to be unique for the genitourinary system, with a particular proclivity for the kidney. Histologically, it is characterized by a unique sinusoidal architecture reminiscent of splenic parenchyma that can lead to concern for angiosarcoma. We herein report a further case of anastomosing hemangioma originating in the right kidney of a 48-year-old Chinese man. The patient had a past medical history significant for hepatocellular carcinoma; this tumor was incidentally identified as an asymptomatic right renal mass during the periodical surveillance of the hepatic cancer. The resected tumor measured 2.5 cm in maximum diameter and microscopically demonstrated an overall lobulated growth pattern with alternating cellular areas composed of anastomosing sinusoidal capillary-sized vessels lined by hobnail endothelial cells, and edematous, hyaline paucicellular areas. Cytologically the tumor cells were generally bland and exhibited positivity for CD31, CD34 immunohistochemically. The patient had been in a good status without evidence of tumor recurrence 12 months after the surgery. This rare variant renal hemangioma is in need of more recognition and should not be over-diagnosed as a malignance, particularly angiosarcoma. PMID:23573324

Zhao, Ming; Li, Changshui; Zheng, Jiangjiang; Sun, Ke

2013-01-01

95

Reticular infantile hemangioma of the limb can be associated with ventral-caudal anomalies, refractory ulceration, and cardiac overload.  

PubMed

We describe six patients with an uncommon variant of infantile hemangioma that we have termed reticular, occurring in the extremity, which were associated with intractable ulceration, anogenito-urinary-sacral anomalies, and sometimes cardiac overload. The extreme end of the spectrum is exemplified by a male neonate who presented with a stained, enlarged, pulsatile lower extremity, and cardiac failure. He also had hepatic hemangiomas and ambiguous genitalia. Progressive soft tissue necrosis and bony destruction necessitated amputation. The histopathologic features differed from those of typical infantile hemangioma: infiltrative (not lobular) and involving fascia, muscle, and bone. The mid-spectrum is illustrated by five females with reticular infantile hemangioma of the lower limb, buttock, and perineum. Four of these infants had a ventral-caudal anomaly, including omphalocele, recto-vaginal fistula, solitary/duplex kidney, imperforate anus, and tethered cord; one infant also had hepatic hemangiomas. Deep ulcerations healed following corticosteroid therapy; one patient required skin graft for closure of a thigh wound. The minor end of the spectrum is exemplified a patchy lesion in the distal limb. The reticular variant of infantile hemangioma can be confused with other vascular anomalies in the limb, such as capillary malformation, cutis marmorata telangiectasia congenita, diffuse arteriovenous malformation (Parkes Weber syndrome) and capillary-lymphatico-venous malformation (Klippel-Trenaunay syndrome). The macular network-like appearance of the tumor and coexisting ventral-caudal structural anomalies is analogous to the association of posterior fossa brain malformations, hemangiomas, arterial anomalies, coarctation of the aorta and cardiac defects, and eye abnormalities association in the craniofacial region. PMID:17845155

Mulliken, John B; Marler, Jennifer J; Burrows, Patricia E; Kozakewich, Harry P W

2007-01-01

96

Natural history of a cervical cavernous hemangioma through two pregnancies.  

PubMed

Hemangiomas of the uterine cervix are extremely rare. The tumor can have a variety of appearance. When a cervical hemangioma is diagnosed in an asymptomatic nulliparous woman or during pregnancy, expectant management is warranted. Surgical intervention, laser, ablation, or Cesarean section is reserved for hemangiomas that present major problems. The natural history of cervical hemangioma is regression and involution. PMID:8503300

Jackson, J

1993-01-01

97

Tufted hemangioma: clinical case and literature review  

PubMed Central

Tufted hemangiomas are relatively rare benign vascular proliferations that are congenital or appear during the first years of life. Herein we present an additional case of tufted hemangioma that appeared one year after birth and discuss its histopathological criteria and differential diagnosis with malignant vascular proliferations including sarcoma Kaposi, angiosarcoma and kaposiform hemangioendothelioma.

Kazlouskaya, Viktoryia; Lytvynenko, Bohdan; Blochin, Elen

2014-01-01

98

Hemangioma as Mass of External Ear Canal  

Microsoft Academic Search

Patient with a round and soft lesion completely covered with skin without modification in color fulfilling approximately 90% of external ear canal diameter. Patient’s complain was dullness sensations on affected ear. CT scan demonstrated lack of tympanic membrane commitment and pathological findings were compatible with hemangioma. Conclusion: It is important to define whether there is hemangioma's involvement of tympanic membrane,

José Faibes Lubianca Neto; Mauricio Schreiner Miura; Catia Saleh; Marina de Andrade; Melina Assmann

99

Cavernous hemangioma of the parietal bone  

PubMed Central

Patient: Male, 38 Final Diagnosis: Cavernous hemangioma Symptoms: Headache • parietal mass Medication: — Clinical Procedure: — Specialty: Neurosurgery Objective: A rare disease Background: Bone hemangioma is a vascular hemartoma of bone structures. In general, this pathology is detected on incidentally investigated patients’ films. Bone hemangioma is most commonly seen in 4th decade of life and the male/female ratio is 1/1.5. The locations of these lesions are commonly long bones of the vertebral column and the skull. Primary bone hemangiomas constitute less than 1% of all bone tumors, and they are seen at 0.2% in the calvarial region. Case Report: Cases with this pathology are seen on incidental radiological evaluations. We report the case of a 38-year-old man with localized headache and a palpable mass in the left parietal region, admitted and operated on after cranial CT and MRI. Pathology investigation revealed a cavernous hemangioma. Conclusions: We suspected that in our case head trauma may have been the cause of cavernous hemangioma in the calvarial region, because cavernous hemangiomas are rarely located there. Localized headache and minor discomfort can be seen with this pathology. The best treatment for cavernous hemangiomas is the removal of the mass within the limits of safe surgery.

Atc?, Ibrahim Burak; Albayrak, Serdal; Y?lmaz, Nejat; Ucler, Necati; Durdag, Emre; Ayden, Omer; Kara, Deniz; Bitlisli, Hulya; Cihangiroglu, Gulcin

2013-01-01

100

Cavernous Hemangioma of Scrotum and Penile Shaft  

Microsoft Academic Search

We report a 13-year-old boy with two independently detected cavernous hemangiomas of the scrotum and the penile shaft. A right scrotal cavernous hemangioma was incidentally found at the age of 6 years by a histological examination of a right scrotal hematoma attributed to contusion. The patient noticed a soft tumor of the penile shaft at the age of 10 and

Hiroyuki Senoh; Yasuji Ichikawa; Akihiko Okuyama; Minato Takaha; Takao Sonoda

1986-01-01

101

Colonic varices due to intestinal cavernous hemangiomas  

Microsoft Academic Search

Summary Colonic varices are an unusual cause of rectal bleeding. Occurring most often in the setting of portal hypertension, colonic varices have also been linked to congenital vascular lesions. One such vascular lesion, the cavernous hemangioma, is rarely found in the bowel. We report a patient with cavernous hemangiomas involving skin, lower extremities, and gastrointestinal tract, who presented with chronic

David A. Lieberman; William W. Krippaehne; Clifford S. Melnyk

1983-01-01

102

Cystic cavernous hemangioma of the liver  

Microsoft Academic Search

We report an unusual case of multilocular cystic cavernous hemangioma of the liver. The patient was a 61-year-old woman without liver disfunction but who had multicystic mass lesions in the liver. Although cavernous hemangiomas are usually accurately diagnosed by the various imaging modalities, our case showed atypical features.

Toshihiko Hihara; Tsutomu Araki; Kunitaka Katou; Hiroaki Odashima; Hiroshi Ounishi; Kenji Kachi; Guio Uchiyama

1990-01-01

103

An Oncocytic Variant of Intraductal Papillary Neoplasm of the Bile Duct that Formed a Giant Hepatic Cyst  

PubMed Central

Intraductal papillary neoplasms of the bile duct (IPNB) is the collective term used to refer to papillary bile duct tumors, mucin producing bile duct tumors, and cystic bile duct tumors. Pathologically, these tumors may be considered a highly differentiated adenocarcinoma or a tumor of borderline malignant potential. IPNB is classified into one of four variants based on cell differentiation. The rarest, oncocytic, is characterized by oxyphilic granular cytoplasm and no mucous cell differentiation. The patient, a 59-year old man, was admitted with a complaint of abdominal fullness and a 30×25 cm cystic mass in the right hepatic lobe demonstrated on computed tomography (CT). The mass had no malignant features on CT or magnetic resonance imaging; however, a portion was FDG avid on 18F-fluorodeoxyglucose positron emission tomography scan (FDG-PET). A fenestration operation was performed for the presumed diagnosis of a hepatic cyst. Pathological examination of the cyst contents demonstrated some atypical cells suspicious for malignancy. After eight months of observation, abnormal FDG uptake was again observed at the residual cyst. A partial hepatectomy was performed to excise the cyst. Pathological examination demonstrated adenocarcinoma in situ derived from an oncocytic IPNB variant. Following the resection, the patient remained disease free for 40 months. This is an extremely rare case of an oncocytic variant of IPNB that was difficult to distinguish clinically from a solitary hepatic cyst.

Watanabe, Akira; Suzuki, Hideki; Kubo, Norio; Araki, Kenichiro; Kobayashi, Tsutomu; Sasaki, Shigeru; Wada, Wataru; Arai, Hideo; Sakamoto, Kazuha; Sakurai, Shinji; Kuwano, Hiroyuki

2013-01-01

104

68Ga DOTATATE Uptake in Vertebral Hemangioma.  

PubMed

Somatostatin receptor scintigraphy is an established modality for imaging well-differentiated neuroendocrine tumors. It is known that inflammatory diseases (eg, tuberculosis) may also accumulate somatostatin receptor analogs. Here, we present the case of a 69-year-old patient with a neuroendocrine tumor of the rectum showing uptake of Ga DOTATATE in 2 vertebrae that was caused by vertebral hemangiomas. This could be clearly demonstrated on the CT scan. Although studies outlining the normal distribution of Ga DOTATATE exist, uptake in vertebral hemangiomas has not been described yet. As the case shows, vertebral hemangiomas should be kept in mind as a benign differential diagnosis. PMID:24152639

Brogsitter, Claudia; Hofmockel, Thomas; Kotzerke, Jörg

2014-05-01

105

Intramuscular sternohyoid hemangioma: an unusual neck mass.  

PubMed

A neck mass with soft consistency suggests the diagnosis of a cyst which is usually congenital in origin. Needle aspiration yielding blood should alert the physician the possibility of hemangioma although it is very rare. Ultrasonography and computed tomography will delineate the extent and nature of the lesion and provide the roadmap for surgical excision. We report a case of a girl who presented with a painless neck mass which was later found to be a hemangioma originating from the sternohyoid muscle. The morphology and immunohistochemical stain were consistent with hemangioma. PMID:23629567

M, Irfan; Soleh, Mohd Najeb; Abdul Rahman, Khairul Shakir; T S, Sharifah Emilia

2013-04-01

106

Primary intraosseous cavernous hemangioma of the toe.  

PubMed

Intraosseous cavernous hemangioma is an uncommon benign vascular tumor. A 21-year-old man presented with a small painless swelling of the left foot's long toe. X-ray examination showed an outgrowing bony lesion that has cortical continuity in the tip of the long toe's distal phalanx lateral aspect. Preoperative examination yielded no final diagnosis. En bloc resection was performed. The histological diagnosis was intraosseous cavernous hemangioma. To the best of our knowledge, this case is a first report of primary intraosseous cavernous hemangioma of the toe. PMID:22042647

Cil, Yakup; Simsek, Hasan Aktug; Y?ld?z, Hamza

2013-12-01

107

Intraosseous Hemangioma of the Inferior Turbinate  

PubMed Central

The nasal cavity harbors an enormous variety of neoplasms, including epithelial and mesenchymal tumors. Hemangioma is an infrequent mesenchymal tumor of the nasal cavity, mostly arising in the mucosa and rarely in the bones. We describe the case of a 73-year-old woman who was referred to our hospital with a tumor in her left nasal cavity. The tumor originated from the left inferior turbinate. Histological examination subsequent to complete excision revealed that the tumor was an intraosseous cavernous hemangioma. To our knowledge, this is the second case of intraosseous hemangioma of the inferior turbinate reported in the English literature.

Takeda, Kazuya; Takenaka, Yukinori; Hashimoto, Michiko

2010-01-01

108

Intraosseous cavernous hemangioma of the skull  

Microsoft Academic Search

Intraosseous cavernous hemangioma is a vascular tumor that only rarely affects the cranial bones. We describe three patients with this unusual tumor and discuss the clinical and radiological features of this lesion in the light of published data.

Luigi Cervoni; Marco Artico; Roberto Delfini

1995-01-01

109

Angiographic manifestations of intracerebral cavernous hemangioma  

Microsoft Academic Search

A case of intraventricular cavernous hemangioma is reported, with a review of the literature, especially that dealing with angiography of intracerebral lesions. Dense venous poolings and a localized area of venous stain were observed in this case.

Y. Numaguchi; M. Fukui; E. Miyake; T. Kishikawa; J. Ikeda; K. Matsuura; M. Tomonaga; K. Kitamura

1977-01-01

110

Pathogenesis of human hemangiosarcomas and hemangiomas.  

PubMed

Hemangiosarcomas are uncommon aggressive vascular tumors that have recently become the focus of attention because several chemicals and pharmaceuticals increase their incidence in mice. The relevance of these mouse vascular tumors to humans is unclear. In the present study, we semiquantitatively evaluated the expression profiles of hematopoietic stem cell markers (CD117 [c-kit], CD133, CD34, and CD45), endothelial cell markers (vascular endothelial growth factor receptor 2, CD31, and factor VIII-related antigen), and a myeloid lineage cell marker (CD14) in human hemangiosarcoma (n = 12) and hemangioma (n = 10) specimens using immunohistochemistry. CD133 was completely negative in almost all cases of hemangiosarcomas and hemangiomas. Most hemangiosarcomas, but not hemangiomas, stained for CD117 and CD45. Both groups diffusely expressed CD34, vascular endothelial growth factor receptor 2, and factor VIII-related antigen; however, hemangiomas had more intense and diffuse CD34 and factor VIII-related antigen expression compared with hemangiosarcomas, whereas CD31 was positive in all hemangiosarcomas but only half of the hemangiomas. CD14 staining was negative in most hemangiosarcoma and hemangioma cases. Our results indicate that multipotential bone marrow-derived hematopoietic stem cells or early endothelial progenitor cells (EPCs) expressing CD117, CD34, and CD45 are involved in hemangiosarcoma formation, whereas hemangiomas originate from late EPCs or differentiated endothelial cells, which have lost the expression of most hematopoietic stem cell markers. This contrasts with our previous results that demonstrated that both hemangiosarcomas and hemangiomas in mice may be derived from early EPCs that are not completely differentiated. PMID:24054722

Liu, Liping; Kakiuchi-Kiyota, Satoko; Arnold, Lora L; Johansson, Sonny L; Wert, David; Cohen, Samuel M

2013-10-01

111

Multifocal photodynamic therapy for diffuse choroidal hemangioma  

PubMed Central

Background A choroidal hemangioma is an uncommon benign vascular tumor of the choroid that can be either circumscribed or diffuse. In our experience, diffuse choroidal hemangiomas in Asian patients often require multiple photodynamic therapy (PDT) treatment sessions. Methods We here provide a case report of a 7-year-old boy with Sturge–Weber syndrome who presented with diffuse choroidal hemangioma in the left eye. Five sessions of PDT treatment were required over a period of 1 year and a final optical coherence tomogram 3 months later revealed resolution of subretinal fluid and the choroidal hemangioma. Results Final visual acuity was 20/100 in the left eye with resolution of subretinal fluid. This case report illustrates that a single application of PDT using standard published parameters was insufficient to achieve the destruction of the enlarged vessels. This experience is similar to previous Chinese reports on circumscribed choroidal hemangiomas. The decision for repeat treatment was based on subretinal fluid recurrence, rather than complete tumor regression. Conclusion Our case report supports previous suggestions that larger dilated vessels in the vascular network of a choroidal hemangioma might affect the efficacy and selectivity of PDT in treating the eyes of Asian patients – which may explain the need for multiple treatments.

Ang, Marcus; Lee, Shu-Yen

2012-01-01

112

Hemangiomas revisited: the useful, the unusual and the new Part 2: endangering hemangiomas and treatment  

Microsoft Academic Search

Hemangiomas, although benign tumors, can when located in particular regions threaten vital structures or in certain clinical\\u000a circumstances be associated with other abnormalities, carrying significant morbidity and mortality. We review these endangering\\u000a hemangiomas. We also discuss briefly the treatment with emphasis on the recent use of propranolol.

Ricardo Restrepo; Rajaneeshankar Palani; Luisa F. Cervantes; Ana-Margarita Duarte; Ibrahim Amjad; Nolan R. Altman

2011-01-01

113

Frontal intraosseous cryptic hemangioma presenting with supraorbital neuralgia.  

PubMed

Primary intraosseous cranial hemangiomas are rare benign tumors comprising 0.2% of all osseous neoplasms. Symptomatic cranial cryptic hemangiomas are extremely rare. We report the case of a 43-year-old man with a cryptic hemangioma of the superior orbital rim. Radiological investigations revealed it to be an intraosseous cryptic mass which was totally excised and the supraorbital nerve was decompressed, relieving the patient of his symptoms. Histopathology showed features of an intraosseous hemangioma. PMID:10536912

Sharma, R R; Pawar, S J; Lad, S D; Netalkar, A S; Musa, M M

1999-09-01

114

Cavernous hemangioma in the submandibular gland masquerading as sialadenitis  

Microsoft Academic Search

This report describes a case of cavernous hemangioma in the submandibular gland of a 37-year-old Irish woman. The lesion clinically and radiologically (as shown both by plain radiographs and computed tomography imaging) resembled salivary calculous disease. Numerous phleboliths were present in the hemangioma. The rarity of a cavernous hemangioma in such a location and its simulation of salivary calculous disease

Máirín McMenamin; Aidan Quinn; Hugh Barry; Duncan Sleeman; Graham Wilson; Mary Toner

1997-01-01

115

Oral hobnail hemangioma: a case report.  

PubMed

Hobnail hemangioma is a benign vascular lesion and intraoral of the lesions are relatively rare. Histopathologically, it shows distinctive biphasic pattern with vascular channels lined by endothelial cells showing characteristic "hobnail" cytomorphology. Since hobnail hemangioma shares similar clinical and histopathologic features with many other benign and malignant vascular tumors, accurate diagnosis is mandatory for proper treatment and prognosis. In the present study, emphasis was given to discuss the differential diagnosis and delineate the hobnail hemangioma from other vascular lesions. Further, immunohistochemical study was performed which showed strong immunopositivity for CD31 and factor VIII in all endothelial cells lining the vascular channels. CD34 was moderately immunopositive and vascular endothelial growth factor was negative. PMID:23808782

Hiremath, Santhosh Kumar S; Charantimath, Shivayogi; Byakodi, Sanjay; Bijjal, Shridevi; Byakodi, Raghavendra; Sapra, Gaurav

2013-07-01

116

Posttraumatic cavernous hemangioma of the skull.  

PubMed

A 59-year-old man presented with a slowly enlarging mass in the lateral orbital rim of the left eye for 1 year. He also reported a history of crania defect in the left front bone (6 years earlier) which was confirmed on the former computed tomographic (CT) scan. On examination, the solid mass lesion located in the left frontal extends to the lateral orbital rim of the left eye. CT scan showed a mass with poorly defined margins, which invaded the neighboring tissue and nearly damaged the bone, and located on the exact site of the preceding crania defect. Complete resection was performed, and the clinical diagnosis of cavernous hemangioma was confirmed on histopathologic examination. Skull cavernous hemangiomas are rare tumors for which the origin is not yet clear. We report a case in which the intraosseous hemangiomas developed at the same site of the preceding crania defect. PMID:24336040

Yu, Juan; Li, Yunping; Duan, Xuanchu

2014-01-01

117

Nuclear magnetic resonance imaging of liver hemangiomas  

SciTech Connect

Nine patients with cavernous hemangioma of the liver were examined by nuclear magnetic resonance imaging (MRI) with a 0.5 T superconductive magnet. Spin-echo technique was used with varying time to echo (TE) and repetition times (TR). Results were compared with /sup 99m/Tc red blood cell (RBC) scintigraphy, computed tomography (CT), echography, and arteriography. Four illustrated cases are reported. It was possible to establish a pattern for MRI characteristics of cavernous hemangiomas; rounded or smooth lobulated shape, marked increase in T1 and T2 values as compared with normal liver values. It is concluded that, although more experience is necessary to compare the specificity with that of ultrasound and CT, MRI proved to be very sensitive for the diagnosis of liver hemangioma, especially in the case of small ones which may be missed by /sup 99m/Tc-labeled RBC scintigraphy.

Sigal, R.; Lanir, A.; Atlan, H.; Naschitz, J.E.; Simon, J.S.; Enat, R.; Front, D.; Israel, O.; Chisin, R.; Krausz, Y.

1985-10-01

118

Epithelioid hemangioma responsive to oral propranolol.  

PubMed

An 11-year-old boy presented with progressive right-sided proptosis and an orbital mass on neuroimaging. Incisional biopsy revealed an epithelioid hemangioma. The patient underwent an orbitotomy with subtotal excision of the mass. However, the tumor recurred and progressed to the cavernous sinus, despite oral steroids, tacrolimus, and a second subtotal excision. Because of encouraging results reported with beta-blockers in the treatment of pediatric capillary hemangiomas, the patient was subsequently started on oral propranolol, 2 mg/kg/day, with discontinuation of steroids and tacrolimus. A rapid and impressive interval decrease in tumor size was observed, with improvement in proptosis and exposure keratopathy. The patient remains without recurrence approximately 9 months after initiation of propranolol. Our results suggest that oral propranolol may be a potential alternative therapy when complete excision of an epithelioid hemangioma is not practical. PMID:22186982

Moss, Hart B; Sines, Daniel T; Blatt, Julie; Dutton, Jonathan J; Proia, Alan D

2012-01-01

119

Oral Propranolol for Circumscribed Choroidal Hemangioma  

PubMed Central

Introduction Several therapeutic approaches have been developed to treat choroidal hemangioma. However, all these therapies are associated with a potential risk of damaging the overlying retina. Case Report We report a case of circumscribed choroidal hemangioma (CCH) in a 59-year-old man refractory to laser treatment. Visual acuity was 20/200 and a serous macular detachment was present. The CCH was treated with oral propanolol, whereupon visual acuity improved to 20/20 and the macular detachment resolved without systemic or local adverse effects. Discussion Propanolol is a ?-blocker commonly used in cardiology that may induce endothelium vasoconstriction and inhibit endothelial proliferation. It has been shown to be effective in infantile facial hemangiomas, and proved safe and effective for the CCH in our patient. Further studies are needed to confirm our observation.

Sanz-Marco, Empar; Gallego, Roberto; Diaz-Llopis, Manuel

2011-01-01

120

Uterine hemangioma: a rare pathologic entity.  

PubMed

Uterine hemangioma is a rare benign tumor usually presenting with menorrhagia or pregnancy-associated complications. Although the current literature identifies fewer than 50 cases, we in our institution identified 5 similar cases among 3700 patients undergoing total hysterectomy from January 2006 to December 2010. Adenomyosis was the most common preoperative diagnosis among our patients. Vaginal examination, uterine curettage specimens, ultrasonography, and hysterography are usually uninformative, and the definitive diagnosis relies on the final histologic examination. The differential diagnosis includes adenomatoid tumor, lymphangioma, and arteriovenous malformation. Uterine hemangiomas are classified into congenital and acquired. The former is believed to be associated with some hereditary diseases, while the latter is associated with both physical changes and hormone alteration, especially high estrogen level. The best treatment for hemangiomas is unclear. However, it is very important to obtain an accurate diagnosis to prevent overtreatment among reproductive-age women. The prognosis is excellent after hysterectomy. PMID:22540306

Chou, Wan-Yi; Chang, Hui-Wen

2012-05-01

121

[Littoral hemangioma of the spleen].  

PubMed

The authors report a rare case of littoral hemangioma of the spleen (LHS) accompanied by a revision of the literature on the argument. A male 65-year-old patient was referred to their attention with suspected ultrasonographic diagnosis of lymphoma with a splenic localisation. The complete CT diagnosis led to suspected splenic angioma. During surgery, anatomopathological analysis of the biopsy revealed LHS. The pathological anatomy showed lesions ranging in size from small foci to large nodules which almost completely replaced the splenic parenchyma. These areas were made up of vascular canals or axes that imitate splenic sinuses and have irregular lumen, often appearing as papillary projections and cyst-like spaces; they are bordered by high (cylindrical) endothelial cells that project into the vascular lumen and reveal hemophagocytosis; there is very little mitotic activity. The patient was discharged 7 days after surgery. The authors underline the extreme rarity of this neoplasm and the virtual absence of symptoms, although some cases report signs of hypersplenism, including platelet deficiency and anemia. The diagnostic iter must take care to exclude other pathologies affecting the spleen, including lymphoma, metastases and primary malignant splenic tumours. Lastly, a differential diagnosis must be made with the malignant variant, littoral hemangiosarcoma of the spleen. PMID:11283486

Voghera, P; Fontana, D; Coverlizza, S; Fusca, M; Della Beffa, V; Pisacane, A M

2001-02-01

122

Endoscopic ultrasound for cavernous hemangioma of rectum  

PubMed Central

Lower gastrointestinal (GI) bleed due to hemangioma in rectum is an uncommon problem. A 19-year-old female patient presented with history of recurrent episodes of lower GI bleeding 1-2 times/month for last 3 years. At the time of hospitalization her vital signs were normal and rectal examination revealed frank blood. Investigations revealed a hemoglobin level of 8.9 g/dL and normal coagulation parameters. Colonoscopy showed bluish reddish elevated nodular lesions limited to distal rectum. Magnetic resonance imaging and endoscopic ultrasound showed cavernous hemangioma.

Sharma, Malay; Adulqader, Almessabi; Shifa, Ruth

2014-01-01

123

Photodynamic Therapy for Juxtapapillary Retinal Capillary Hemangioma  

PubMed Central

Various treatment modalities have been described for retinal capillary hemangioma. Our purpose is to present a case of juxtapapillary retinal capillary hemangioma treated with photodynamic therapy. A 69-year-old woman with no previous ocular history presented with blurred vision and photopsias in the right eye three months ago. At presentation, her best corrected visual acuity was 6/9 in the right eye and 6/6 in the left eye. The anterior segment was totally normal and IOP was normal in both eyes as well. Dilated fundoscopy revealed a yellowish, well-circumscribed, elevated area with blood vessels, on the inferior margin of the right optic disc, as optic disc edema. Fluorescein angiography and angiogram with indocyanine green confirmed the diagnosis of juxtapapillary retinal capillary hemangioma. The patient was treated with photodynamic therapy with verteporfin and three months later her visual acuity was 6/7.5 in the right eye, while the lesion was slightly smaller. These findings remained stable at the one-year follow-up. In conclusion, photodynamic therapy offers promising anatomical and functional results for juxtapapillary retinal capillary hemangioma, providing visual acuity improvement or even stabilization and restriction of enlargement of the lesion.

Mitropoulos, Panagiotis G.; Chatziralli, Irini P.; Peponis, Vasileios G.; Tsiotra, Vasileia A.; Parikakis, Efstratios A.

2014-01-01

124

Hemangioma of the rectum: CT appearance  

Microsoft Academic Search

An 18-year-old man who had severe recurrent rectal bleeding and hematuria was found to have a diffuse cavernous hemangioma of the rectosigmoid. A computed tomographic (CT) study was indicated to evaluate tumor extension and therapeutic possibilities. CT scanning revealed a large mass with phleboliths throughout the true pelvis and nodular indentations in the rectosigmoid wall involving the dome and posterior

C. Pérez; J. Andreu; J. Llauger; J. Valls

1987-01-01

125

Bone erosion caused by orbital cavernous hemangioma  

Microsoft Academic Search

Bone erosion is commonly associated with malignant or infiltrative orbital lesions. It is unusual to have bone erosion in\\u000a association with benign focal orbital tumors. We report a case of large orbital cavernous hemangioma that showed bone erosion\\u000a on computed tomography.

Riad N. Ma'luf; Nabil J. Khoury; Usama M. Hadi

2000-01-01

126

Percutaneous vertebroplasty in painful refractory vertebral hemangiomas  

PubMed Central

Background: Painful vertebral hemangiomas are often inadequately managed medically. We evaluated the outcome of percutaneous vertebroplasty (PVP) in the treatment of painful vertebral hemangiomas refractory to medical management. Materials and Methods: 14 patients (four thoracic and ten lumbar vertebra) with painful vertebral hemangiomas presenting with severe back pain for more than 6 months not responding to medical therapy were treated by vertebroplasty. Cross sectional imaging of the spine with magnetic resonance was done. Blood investigations were done to exclude coagulopathy excluded. PVP was performed under local anesthesia. Results: The pain intensity numeric rating scale (PI-NRS-11) of these patients was in the range of 7-10 (Severe Pain). After vertebroplasty 8 patients were completely free of pain (PI NRS Score 0) while 6 were significantly relieved (PI-NRS Score 1-3). No complications were observed. Two patients with associated radicular pain had good pain relief following PVP. No recurrence was found during 36 months of postoperative followup. Conclusion: PVP is a safe and effective procedure in patients with painful vertebral hemangiomas refractory to medical management.

Narayana, RV; Pati, Rajesh; Dalai, Sibasankar

2014-01-01

127

Masson's hemangioma: A rare intraoral presentation  

PubMed Central

An otherwise healthy 19-year-old female patient had painless swelling in her left buccal mucosa. No precipitating factors were identified. Pathological analysis demonstrated the mass to be a Masson's hemangioma, a papillary proliferation of thin-walled capillaries intimately associated with thrombus. A very rare tumor occurring in oral cavity with only 80 cases being published in literature until date.

Narwal, Anjali; Sen, Rajeev; Singh, Virender; Gupta, Ambika

2013-01-01

128

[Giant chorioangioma of the placenta].  

PubMed

The paper describes a case of giant (123 x 109 x 70-mm) placental chorioangioma that is a capillary hemangioma in structure, which led to significantly impaired placental-fetal blood flow to give rise to non-immune hydrops and right heart failure in the fetus at 33 weeks' gestation; obvious polyhydramnios developed. This served as an indication for preterm one-stage cesarean delivery. A premature live girl was born with a weight of 2430 g, a height of 44 cm, Apgar score 6-7. Dynamic echographic monitoring makes it possible to record increased placental tumor sizes and fetal abnormalities and to make a timely decision on delivery, which promotes perinatal death prevention. At 11-month follow-up, the child's physical and mental developments were for age. PMID:24341234

Kazachkov, E L; Voropaeva, E E; Semenov, Iu A; Pasternak, A E; kazachkova, E A

2013-01-01

129

Gastrointestinal hemangioma in childhood: a rare cause of gastrointestinal bleeding  

PubMed Central

Gastrointestinal (GI) hemangiomas are relatively rare benign vascular tumors. The choice of an appropriate diagnostic method depends on patient age, anatomic location, and presenting symptoms. However, GI hemangiomas are not a common suspected cause of GI bleeding in children because of their rarity. Based on medical history, laboratory results, and imaging study findings, the patient could be treated with either medication or surgery. Herein, we report 3 cases of GI hemangioma found in the small bowel, rectum, and GI tract (multiple hemangiomas). Better knowledge and understanding of GI hemangioma could help reduce the delayed diagnosis rate and prevent inappropriate management. Although rare, GI hemangiomas should be considered in the differential diagnosis of GI bleeding.

Han, Eon Chul; Kim, Soo-Hong; Jung, Sung-Eun; Park, Kwi-Won

2014-01-01

130

Frontal intraosseous cryptic hemangioma presenting with supraorbital neuralgia  

Microsoft Academic Search

Primary intraosseous cranial hemangiomas are rare benign tumors comprising 0.2% of all osseous neoplasms. Symptomatic cranial cryptic hemangiomas are extremely rare. We report the case of a 43-year-old man with a cryptic hemangioma of the superior orbital rim. Radiological investigations revealed it to be an intraosseous cryptic mass which was totally excised and the supraorbital nerve was decompressed, relieving the

Rewati Raman Sharma; Sanjay J. Pawar; Santosh D. Lad; Audumbar S. Netalkar; Mohammed M. Musa

1999-01-01

131

Hemangioma in minor salivary glands: real or illusion.  

PubMed

Hemangioma is a common soft tissue lesion in the head and neck region. Hemangioma in the context of minor salivary glands is rarely encountered in surgical pathology practice, and for this reason most pathologist are often unfamiliar with its histomorphological features. We report a rare histological finding of salivary gland structures within a cavernous hemangioma, which may or may not have originated in the minor salivary gland. PMID:17002811

Ponniah, Irulandy; SureshKumar, Palani; Karunakaran, Kaliappan; Shankar, Kolappan A; Kumaran, Mayelam G; Preeti, Lakshmi Narasimhan

2006-01-01

132

[Diagnosis and surgical treatment of cavernous hemangioma of the liver].  

PubMed

Results of surgical treatment of cavernous liner hemangiomas in 47 patients have been analysed. In 7 cases the original method of surgery in unresectable liver hemangiomas was used. The method was designed by the authors of the article. The proper diagnosis of liver hemangiomas is possible in the specialized divisions only. Ultrasound examination, CT and laparoscopy play the major role in diagnosis. Anatomical liver resection is the major surgical method. In cases of unresectable hemangiomas the method of omento-hepatopexy with subsequent X-ray therapy is indicated. PMID:8754893

Vecherko, V N; Gredzhev, F A; Konoplia, P P

1996-01-01

133

Cavernous hemangioma with large phlebolith of the parotid gland.  

PubMed

Hemangiomas are vascular anomalies characterized by increased proliferation and turnover of endothelial cells. Hemangiomas of the parotid region are relatively uncommon in adult population, and there are a few reports of hemangioma with large phlebolith within the parotid gland. We herein report a case of it. Sialography may be a useful investigation method in the evaluation of radiopaque lesions localized intraglandularly in the parotid area to rule out the sialolith. Cavernous hemangioma with phleboliths should be included in the differential diagnosis of a swelling in the mandibular area. PMID:24220486

Choi, Hwan Jun; Lee, Joo Chul; Kim, Jun Hyuk; Lee, Young Man; Lee, Hyun Joo

2013-11-01

134

PHACE without face? Infantile hemangiomas of the upper body region with minimal or absent facial hemangiomas and associated structural malformations.  

PubMed

Infantile hemangiomas can be associated with congenital anomalies such as PHACE syndrome with facial hemangiomas and genitourinary and spinal anomalies in the setting of lower body hemangiomas. We describe five infants in whom segmental hemangiomas involving the upper torso and extremities with absent or small facial hemangiomas were associated with structural anomalies similar to those reported with PHACE syndrome, including three with structural arterial anomalies of the subclavian arteries, three with aortic arch anomalies (right sided or narrowed arch), two with congenital heart disease (atrial septal defect and ventricular septal defect; tetralogy of Fallot), one with a retinal scar, and one with a sternal defect (scar). Two of five had small facial hemangiomas of the lower lip, but none had large segmental hemangiomas of the face. Three of five would have met diagnostic criteria for PHACE but lacked a facial hemangioma of 5 cm in diameter or greater. Patients with segmental arm and thorax hemangiomas may have associated structural abnormalities with overlapping features of PHACE, suggesting that a similar syndrome can occur in this clinical setting. PMID:21453307

Nabatian, Adam S; Milgraum, Sandy S; Hess, Christopher P; Mancini, Anthony J; Krol, Alfons; Frieden, Ilona J

2011-01-01

135

Co-development of pyogenic granuloma and capillary hemangioma on the alveolar ridge associated with a dental implant: a case report  

PubMed Central

Introduction The development of various benign oral mucosal lesions associated with dental implants, such as pyogenic granuloma or peripheral giant cell granuloma, has been rarely reported. However, the occurrence of vascular diseases, such as hemangioma, related to dental implants has not been explored in the literature. In this study, we report a case of co-development of pyogenic granuloma and capillary hemangioma on the alveolar ridge associated with a dental implant in a patient undergoing antithrombotic therapy. To the best of our knowledge, this is first case of hemangioma formation associated with a dental implant. Case presentation A 68-year-old Korean man was referred for intermittent bleeding and a dome-shaped overgrowing mass on his upper alveolar ridge. He underwent dental implantation 5 years ago, and was started on warfarin for cerebral infarction a year ago. He had experienced gum bleeding and gingival mass formation 6 months after warfarinization; then, his implant fixture was removed. However, his gingival mass has been gradually increasing. The gingival mass was surgically excised, and revealed the coexistence of pyogenic granuloma and capillary hemangioma in histological analysis of the specimen. The lesion has showed no recurrence for more than a year. Conclusions Regarding immunostaining features, the endothelial cell markers, CD34 and CD31, and the mesenchymal cell marker, vimentin, were strongly detected, but cell proliferation marker, Ki-67, was negatively expressed in the endothelial cells of the hemangioma portion. However, in the pyogenic granuloma portion, CD34 was almost negatively detected, whereas vimentin and Ki-67 were highly detected in the fibroblast-like tumor cells. According to these heterogeneous characteristics of the lesion, the patient was diagnosed with coexistence of pyogenic granuloma and capillary hemangioma associated with the dental implant on the attached gingiva. We recommend that patients with dental implants who have chronic peri-implantitis under antithrombotic therapy should be closely followed to ensure early detection of oral mucosal abnormalities.

2014-01-01

136

Intraosseous hemangioma arising in the clavicle.  

PubMed

Intraosseous hemangioma (IH) is commonly seen in the vertebral column and skull: however, IH occurring in the appendicular skeleton, including the clavicle, is uncommon. We herein report the case of a 69-year-old female presenting with IH of the left clavicle. The findings of preoperative imaging studies, including radiographs, computed tomography (CT), magnetic resonance imaging, fluorine-18-fludeoxyglucose ((18)F-FDG) positron emission tomography (PET)/CT and ultrasonography, are described. In particular, (18)F-FDG PET/CT showed an ill-defined osteolytic lesion with abnormally high FDG uptake. Surgical en bloc resection with preoperative embolization was carried out and a histopathological examination confirmed the presence of an intraosseous cavernous hemangioma in the clavicle. PMID:23990112

Matsumoto, Yoshihiro; Takahashi, Yusuke; Haraguchi, Akihisa; Okamoto, Tatsuro; Harimaya, Katsumi; Matsunobu, Tomoya; Endo, Makoto; Oda, Yoshinao; Iwamoto, Yukihide

2014-01-01

137

Mimicry of lyme arthritis by synovial hemangioma.  

PubMed

To report on the differential diagnosis of lyme arthritis and synovial hemangioma due to similar clinical and radiological signs and symptoms. A 15-year-old boy presented at the age of 9 with recurrent rather painless swelling of the right knee. Altogether four episodes lasting for 1-2 weeks each occurred over a period of 18 months before medical advice was sought. Physical examination revealed only a slightly limited range of motion. Living in an endemic area of borreliosis, he reported a tick bite 6 months prior to onset of his symptoms with erythema migrans and was treated for 10 days with amoxicillin. Serology revealed two positive unspecific bands in IgG immunoblot (p41 and 66) with slight positivity for ELISA. Ultrasound revealed synovial thickening and increased fluid. Despite the weak positive serology a diagnosis of lyme arthritis could not be excluded and intravenous antibiotic treatment with ceftriaxone was started. After two further relapses antiinflammatory therapy including intraarticular steroids were introduced with no long lasting effect. A chronical disease developed with alternate periods of swelling and almost complete remission. Ultrasound as well as MRI demonstrated ongoing signs of synovitis, therefore after further progression, a diagnostic arthroscopy was performed showing an inconspicuous knee joint. A second MRI showed focal suprapatellar enhancement and was followed by open arthrotomy revealing a histopathological proven synovial cavernous juxtaarticular hemangioma. To our knowledge, the differential diagnosis of lyme arthritis and synovial hemangioma has not yet been reported despite obvious clinical similarities. In conclusion, in children and adolescents synovial hemangioma has to be considered in differential diagnosis of recurrent knee swelling. Early diagnosis is important to prevent prolonged suffering from chronic joint swelling with probable joint damages, unnecessary treatment procedures and as well school and sports absenteeism. PMID:20013264

Hospach, Toni; Langendörfer, M; Kalle, T V; Tewald, F; Wirth, T; Dannecker, G E

2011-12-01

138

Progesterone receptor expression in orbital cavernous hemangiomas  

Microsoft Academic Search

Orbital cavernous hemangiomas (OCH) have thick and highly cellular vascular walls. Ultrastructural studies have demonstrated\\u000a the smooth muscle nature of these cells. Vascular neoplasms can modify their morphological and clinical features under hormonal\\u000a stimulation. The purpose of the present study was to investigate the presence of smooth muscle markers and sex steroid receptors\\u000a in 12 cases of OCH. Orbital cases

Luca Di Tommaso; Francesca Scarpellini; Fabrizio Salvi; Teresa Ragazzini; Maria P. Foschini

2000-01-01

139

Primary intraosseous cavernous hemangioma of the orbit  

Microsoft Academic Search

PURPOSE: Primary orbital intraosseous hemangioma is a rare, benign neoplasm presenting most frequently in patients in their fourth or fifth decade of life. We describe an elderly patient affected by this tumor.METHODS: Case report.RESULTS: A 75-year-old man presented with a slowly growing, bony mass in the left orbital rim inferolaterally. He had a history of nephrectomy because of a renal

Fernando Colombo; Claus Cursiefen; Carmen Hofmann-Rummelt; Leonard M Holbach

2001-01-01

140

Cavernous hemangioma arising from the diaphragm.  

PubMed

A 51-year-old man was referred to our hospital with an abnormal nodule in the right lung field. Computed tomography revealed a homogeneous nodule adjacent to the diaphragm, which appeared to be an extrapulmonary lesion. No hilar or mediastinal lymph node swelling was detected, and positron-emission tomography showed no significant uptake. At surgery, 2 red papillary tumors were found, originating from the right diaphragm, and tumor extirpation was performed. The pathological diagnosis was cavernous hemangioma. PMID:24569338

Ueno, Katsuhito; Takeuchi, Eriho; Hino, Haruaki; Kawashima, Mitsuaki

2013-12-01

141

Cavernous hemangioma of the rectum and rectosigmoid  

Microsoft Academic Search

Summary  Hemangioma of the colon and rectum, although a rare condition, can be diagnosed preoperatively if the condition is considered\\u000a in the light of certain historical and clinical findings. A long history of continuous bleeding in small quantities or episodes\\u000a of massive rectal bleeding are the outstanding diagnostic features elicited while taking the patient’s history. Suggestive\\u000a ancillary findings include the appearance

Gerald W. Parker; Joseph A. Murney; Wilbur L. Kenoyer

1960-01-01

142

Cavernous hemangioma with rapidly developing proptosis  

Microsoft Academic Search

Purpose: To report an unusual case of cavernous hemangioma with rapidly developing proptosis. Methods: Case report. The clinical features, imaging findings and orbital surgery were presented. Results: A 54-year-old man presented with rapidly developing proptosis and a mass in the lower eyelid of his left eye for 8 h. The\\u000a left eye had 5 mm of proptosis. Color Doppler ultrasonography and computed

Jianhua Yan; Xianggui Wang

2008-01-01

143

Ultrasonographic diagnosis of an unusual vesical hemangioma presenting as hydroureteronephrosis.  

PubMed

Vesical hemangiomas are rare and benign tumors of mesenchymal origin. They usually present with multiple episodes of hematuria and the diagnosis is usually achieved patho-logically. We present a rare case of vesical hemangioma at vesicoureteric junction that presented with abdominal pain secondary to hydroureteronephrosis and the diagnosis was suspected on ultrasonography and confirmed later by pathology. PMID:20061708

Rastogi, Rajul; Bhargava, Sumeet; Sachdeva, Inderjeet Singh; Rastogi, Vaibhav

2010-01-01

144

Treatment of hemangiomas of infants with high doses of prednisone  

Microsoft Academic Search

OBJECTIVE: We reviewed our experience with the use of oral corticosteroid therapy in treating hemangiomas of infants to determine the optimal effective dose. STUDY DESIGN: During a 24-year period, 60 infants with hemangiomas were treated with an initial dose of either 3 or 5 mg\\/kg per day of orally administered prednisone for a period ranging from 6 to 12 weeks.

Naum Sadan; Baruch Wolach

1996-01-01

145

Hemangioma of the Prostatic Urethra: Holmium Laser Treatment  

Microsoft Academic Search

Urethral hemangiomas are benign vascular tumors that are found in perimontanal prostatic localization and less frequently in the urethra. Although different urethral procedures have been postulated for its treatment, the best results are achieved using lasers. A patient who underwent endoscopic holmium laser treatment for such hemangiomas is presented. Total disappearance of the lesions without any complications was achieved.

Javier Ponce de León; Jacobo Arce; Luís Gausa; Humberto Villavicencio

2008-01-01

146

Sellar and parasellar extra-axial cavernous hemangiomas  

Microsoft Academic Search

Summary Cavernous hemangiomas can grow extra-axially within dural sinuses, particularly the cavernous sinus and present like tumours. Five cases of cavernous hemangiomas arising within or from the wall of the cavernous sinus are reported. Three of them had an “endophytic” growth within the cavernous sinus with a lateral extension into the middle cranial fossa, a medial extension into the sella

D. Lombardi; M. Giovanelli; N. de Tribolet

1994-01-01

147

Diffuse sphenoid bone cavernous hemangioma presenting during pregnancy.  

PubMed

We present a case of diffuse sphenoid bone cavernous hemangioma in a 22-year-old primigravid woman. Her disease first manifested clinically as progressively decreasing vision in her left eye during her third trimester of pregnancy. We also discuss the known causes and some theoretical causes of cavernous hemangioma enlargement during pregnancy. PMID:24170470

Robertson, Hugh; Palacios, Enrique; Rincon, Sheryl; Shah, Kamal R

2013-01-01

148

Cavernous hemangioma. Why is peripheral filling at scintigraphy so rare  

SciTech Connect

Peripheral filling at dynamic CT occurs frequently with cavernous hemangiomas, yet this phenomenon is a rare finding on Tc-99m RBC imaging. A case of peripheral filling of a cavernous hemangioma with scintigraphy is reported and the rationale for its infrequent occurrence is discussed.

Drane, W.E.; Weatherby, E. III

1987-10-01

149

Calcifying cerebral cavernous hemangioma with brain scan and angiographic findings  

Microsoft Academic Search

A case of a cavernous hemangioma of the right frontal lobe of the brain is reported. The lesion showed a myriad of tiny discrete calcifications and was associated with a well-circumscribed uptake on technetium brain scan and positive findings on cerebral angiography. The patient has done well since excision of the hemangioma.

H. D. Segall; H. L. Segal; J. S. Teal; C. L. Rumbaugh; R. T. Bergeron

1974-01-01

150

Radiosurgery of cavernous hemangiomas in the cavernous sinus  

Microsoft Academic Search

BACKGROUNDCavernous hemangiomas in the cavernous sinus are rare and demonstrate unique clinical courses. Although they rarely cause spontaneous bleeding, serious bleeding is not uncommon during operations. Total eradication of such tumors is very difficult because of the location and intraoperative bleeding. Consequently, alternatives to operative resection have been examined.METHODSThree cases of cavernous hemangiomas in the cavernous sinus, presenting chiefly with

Yoshihisa Kida; Tatsuya Kobayashi; Yoshimasa Mori

2001-01-01

151

Intracerebral cavernous hemangioma with angiographically demonstrated pathologic vasculature  

Microsoft Academic Search

Cerebral cavernous hemangiomas are rare vascular malformations. In the ten cases previously studied by angiography, arterial displacement was demonstrated, but pathologic vasculature has not been seen. The first patient with a cavernoma in which neovasculature, a stain, and early venous filling were discernible at angiography is described. Because of the relative ease of the surgical removal of cavernous hemangiomas, they

A. J. Jonutis; F. K. Sondheimer; H. Z. Klein; B. L. Wise

1971-01-01

152

[Cavernous hemangioma in the orbital apex revealed by optic neuropathy].  

PubMed

Cavernous hemangioma is the most common primary vascular neoplasm. It typically occurs in middle-aged women, causing a progressive painless proptosis as the principal symptom. It exceptionally compresses the optic nerve. We report the case of a cavernous hemangioma revealed by optic neuropathy in a 33-year-old female. PMID:20347181

Baklouti, K; Ayachi, M; Chaker, N; Ahmed, N Ben; Mrabet, A; Kammoun, S; Kilani, W; Khanoussi, S; Matri, L El

2010-04-01

153

Vascular tumors in the orbit—capillary and cavernous hemangiomas  

Microsoft Academic Search

Vascular tumors in the orbit result from new formation of vessels, proliferation of tissue components of the vessel wall, and hyperplasia of cellular elements ordinarily concerned with the genesis of vascular tissue. These vasculogenic lesions constitute the largest group of primary orbital tumors; we present the capillary hemangioma and the cavernous hemangioma.

Tatiana I. Rosca; Monica I. Pop; Manuela Curca; Teodora Gh. Vladescu; Cecilia St. Tihoan; Ana Tatiana T. Serban; Ecaterina Al. Bontas; Gheorghe Gherghescu

2006-01-01

154

A case of subcutaneous hemangioma presenting as a preauricular sinus.  

PubMed

Hemangioma is one of the most common benign neoplasm involved on head and neck. However, cavernous hemangiomas are relatively rare in preauricular sinus space and has rarely been reported around the world. Recently, a 44-year-old female patient came to our clinic with cavernous hemangioma involving the preauricular sinus. This case was surgically managed via excision. Preoperatively, it was difficult to differentiate the mass of hemangioma clinically and diagnostically from a preauricular fistula, a salivary gland tumor, or an enchondroma. This case report describes the subcutaneous hemangioma on a preauricular sinus, which is rarely seen in Korea. The clinical presentation and management are discussed with a review of the literature. PMID:24653902

Jin, Sang-Gyun; Kim, Min-Ju; Park, Jung-Mi; Park, Kyoung-Ho

2013-04-01

155

Recurrent Orbital Cavernous Hemangioma due to Overlooked Multiple Tumors  

PubMed Central

Purpose To report late recurrence of orbital cavernous hemangioma in a patient ten years after complete resection of the primary tumor. Case Report A 32-year-old woman with a history of progressive visual loss and proptosis underwent lateral orbitotomy for resection of a large cavernous hemangioma. Ten years later, proptosis recurred and the patient developed progressive ocular deviation. Imaging studies were in favor of a recurrent cavernous hemangioma and the tumor was excised via the previous incision site. Reassessment of previous orbital images suggested the presence of two separate tumors, only one of which had been excised at the time of initial surgery. Conclusion Recurrent orbital cavernous hemangioma may follow incomplete excision of multiple orbital lesions with gradual growth of unidentified residual tumors. Accordingly, when an encapsulated cavernous hemangioma is removed, exploration is recommended to rule out multiple lesions.

Bagheri, Abbas; Khandan, Sakineh; Salour, Hossein; Aletaha, Maryam; Abrishami, Alireza

2012-01-01

156

Giant Squid  

NSDL National Science Digital Library

How do you get two dead Giant Squid the size of a school bus from a fishing boat in Spain to a museum in Washington, DC, USA? Call in the Navy! Find out how Operation Calamari unfolded and how the museum managed to put their new Giant Squid on display. Also included is a Learn More section that provides background information on the scientists recorded in the podcast, lessons, images, and cool facts.

2009-01-01

157

Technetium-99m-labeled red blood cells in the evaluation of hemangiomas of the liver in infants and children  

SciTech Connect

The vascular origin lesions of the liver (capillary hemangioma/infantile hemangioendothelioma) that present in infancy or early childhood often have a typical clinical picture of hepatomegaly and congestive heart failure. These lesions rarely present as asymptomatic hepatomegaly, simulating a primary hepatic malignancy. These lesions may also simulate a primary or secondary hepatic malignancy on cross-sectional imaging or angiography. Scintigraphic evaluations with technetium-99m-labeled red blood cells offers an accurate method of identification of these lesions, and allows differentiation from other common primary or secondary hepatic masses in infancy or childhood. This scintigraphic method may also be used to follow these patients after medical, radiation, or embolization therapy. Experience with seven patients with these tumors is reported and compared with eight children with other primary or secondary liver tumors also evaluated by this method.

Miller, J.H.

1987-09-01

158

Masson's intravascular hemangioma masquerading as effort thrombosis.  

PubMed

An otherwise healthy 55-year-old white woman had acute onset of right arm swelling. No precipitating factors were identified. Venograms revealed an occluded subclavian vein, and catheter-directed thrombolysis was performed. After lysis a persistent residual intraluminal filling defect was identified, with persistent symptoms. Partial claviculectomy was performed, the mass was removed, and patch venoplasty carried out, with good outcome. Pathologic analysis demonstrated the mass to be a Masson's hemangioma, a papillary proliferation of thin-walled capillaries intimately associated with thrombus. Considered a benign intravascular lesion, the treatment of choice is complete excision. PMID:15472612

Kumar, Amit; Surowiec, Scott; Nigwekar, Priya; Illig, Karl A

2004-10-01

159

Pathology Case Study: Hemangioma and Severe Thrombocytopenia  

NSDL National Science Digital Library

This is a transfusion pathology case study presented by the University of Pittsburgh Department of Pathology in which a 3-week-old female has hemangioma and severe thrombocytopenia. Visitors are given laboratory values and images, and are granted the opportunity to diagnose the patient. This is an excellent resource for students in the health sciences to familiarize themselves with using laboratory results to diagnose. It is also a helpful site for educators to use to introduce or test student learning in transfusion pathology medicine.

Bontempo, Franklin; Dorvault, Christine

2007-10-09

160

Orbital cavernous hemangioma with bone erosion  

Microsoft Academic Search

Purpose  To report a rare computed tomography (CT) feature in one case of orbital cavernous hemangioma (OCH).\\u000a \\u000a \\u000a \\u000a Methods  Case report. The clinical features, CT findings, and pathological examination are presented.\\u000a \\u000a \\u000a \\u000a Results  A 43-year-old Chinese man developed slowly progressive proptosis and decreased vision in his left eye over 13 years. The best-corrected\\u000a visual acuity was 20\\/400 OS. Fundus examination showed moderate disc pallor in

Jianhua Yan; Yongping Li; Zhongyao Wu

2006-01-01

161

Primary cavernous hemangioma of the thyroid gland.  

PubMed

A 78-year-old euthyroid patient presented for evaluation of a symptomatic, slowly growing neck mass. Ultrasound scan revealed a multinodular goiter and a hypoechoic nodule of the right thyroid lobe. Total thyroidectomy was performed and the lesion was completely excised. Definite diagnosis was obtained after histological examination of the surgical specimen. Cavernous hemangiomas of the thyroid gland are infrequent lesions which may escape diagnosis preoperatively. An effort should be made not to rupture these lesions in order to ensure a bloodless procedure. PMID:20531063

Michalopoulos, Nikolaos V; Markogiannakis, Haridimos; Kekis, Panagiotis B; Papadima, Artemisia; Lagoudianakis, Emmanuel; Manouras, Andreas

2010-07-01

162

Hemangiomas cutáneos. Análisis clínico- patológico con especial énfasis en nuevos hallazgos microscópicos Cutaneous hemangiomas. A clinicopathological analysis with special emphasis in novel microscopic findings  

Microsoft Academic Search

Summary Hemangiomas are the most frequent vascular skin neoplasms, but there are no studies defining their frequency. Objectives: To determine the frequency of presentation in the different cutaneous hemangiomas in biopsy specimens submitted to our service, and to verify the level of clinicopathological correlation established in cutaneous hemangiomas. Methods: Archives of biopsy reports and specimens of any kind of cutaneous

Guillermo Solís Ledesmaa; Luis Miguel; Moreno López; Jorge Peniche Rosadob; Patricia Mercadillo Péreza; Patricia Mercadillo Pérez

163

[Intermittent rectorrhagia due to diffuse hemangioma of the rectum].  

PubMed

Diffuse hemangioma of the rectum is a rare benign vascular lesion. The case of a 30 year-old male with intermittent rectal bleeding with an evolution of 2 years and symptoms related to chronic ferropenic anemia is presented. The rectal endoscopy was interpreted as a malignant neoplastic epithelial lesion spread throughout the rectum. The biopsy indicated that it was a rectal hemangioma. A surgical resection was successfully performed. The study of the surgical specimen concluded that it was a diffuse rectal hemangioma. PMID:18641778

Díaz Ríos, Ramiro; Pérez Pereyra, Julia; Perea Guerrero, Humberto; Palomino Portilla, Américo; Frisancho Velarde, Oscar

2008-01-01

164

Multiple intracranial capillary hemangiomas and transient cerebrovascular insufficiency.  

PubMed

Hemangiomas constitute a heterogeneous group of benign vascular proliferations of skin and mucous membranes and very rarely known to develop in the brain or spinal cord. We report here a case of multiple intracranial capillary hemangiomas presenting with transient neurological deficit. The patient underwent stealth MRI brain utilizing 15 ml of Magnevist for stereotactic localization and biopsy was done to establish the diagnosis. It is pivotal to differentiate benign hemangiomas from primary cerebral vascular tumors including hemangioblastoma, hemangioendothelioma and hemangiopericytoma, as later are known for more aggressive biologic behavior. PMID:21533565

Younas, Fahad; Durrani, Quratulain; Shahzad, Muhammad A; Mushtaq, Asim; Imlay, Sherwin

2011-10-01

165

Capillary hemangioma or pyogenic granuloma: A diagnostic dilemma  

PubMed Central

Pyogenic granulomas and hemangiomas of oral cavity are well-known benign lesions. Although pyogenic granuloma is known to show a striking predilection for the gingiva and capillary hemangioma for lips, check, and tongue, palatal occurrence of these lesions is extremely rare. The clinical diagnosis of such an uncommon occurrence can be quite challenging as they sometimes may mimic more serious lesions such as malignancies. The purpose of this article is to report an unusual case of benign tumor occurring on hard palate which was clinically diagnosed as pyogenic granuloma and histopathologically as capillary hemangioma.

Rachappa, M. M.; Triveni, M. N.

2010-01-01

166

Epithelioid hemangioma of the orbit or angiolymphoid hyperplasia with eosinophilia.  

PubMed

A patient was referred to the department for an incidentally discovered right orbital mass on MRI. After surgical excision, histopathologic examination led to the diagnosis of epithelioid hemangioma, a tumor rarely located in the orbit, whose main histopathologic feature is an exuberant proliferation of small vascular channels lined by enlarged endothelial cells. The clinical characteristics and histopathology of epithelioid hemangioma allow differentiation with Kimura disease, angiosarcoma, intravascular papillary endothelial hyperplasia, and other vascular tumors that share the common feature of an abnormal proliferation of endothelial cells. Although epithelioid hemangioma is extremely rare, it should be considered in the differential diagnosis of orbital tumors. PMID:24026000

Sánchez-Orgaz, Margarita; Insausti-García, Alfredo; Gregorio, Laura Yébenes; Duralde, Alvaro Arbizu; Romero-Martín, Ricardo

2014-01-01

167

A case of scalp cavernous hemangioma simulating sinus pericranii.  

PubMed

The authors report a case of cavernous hemangioma in the occipital region, which resembled sinus pericranii, protruded in the recumbent posture. A 28-year-old male was admitted with a chief complaint of an occipital fluctuating mass, 5cm in diameter, accompanied by slight pain. The skull X-P was normal. A direct puncture revealed that the lesion was a blood cyst. A cystogram by percutaneous needle puncture revealed paramedian blood pooling with some draining veins but did not show any transcranial communicating vessels. A T2 weighted MR image demonstrated a well demarcated high intensity lesion just beneath the corium. The subtotally removed specimen turned out to be a cavernous hemangioma. We discerned a conceptual confusion of pseudosinus pericranii with scalp cavernous hemangioma, based on the literature review. And we propose that scalp cavernous hemangioma, even if it changes its size according to posture, should not be simply designated as sinus pericranii. PMID:1572806

Arita, K; Uozumi, T; Kuwabara, S; Kiya, K; Sumida, M; Iida, K; Muttaqin, Z; Monden, S; Miyamoto, Y

1992-03-01

168

[Rapidly involuting congenital hemangiomas: twenty five case series].  

PubMed

Rapidly involuting congenital hemangiomas are very rare vascular tumours, that are characterized for being completely developed at birth and for involuting in a short period of time after birth. We describe a case series of 25 patients with rapidly involuting congenital hemangiomas. Twelve patients were male and 13 female; they were all born at term. Lesions were small in 17 cases and big in 8. No patient needed active intervention and all lesions showed a rapid initial involution. PMID:24584803

Larralde, Margarita; Solé, Juan Javier; Luna, Paula Carolina; Mosquera, Tomás; Abad, María Eugenia

2014-04-01

169

Cavernous hemangioma of the skull in a neonate  

Microsoft Academic Search

Cavernous hemangiomas rarely occur in the calvarium and most commonly present in middle-age. Although a congenital vascular\\u000a disorder can theoretically cause a diploic lesion in any age group, a calvarial cavernous hemangioma has not been reported\\u000a in newborn. A 4-month-old male infant presented with a large left parietal mass that had been present since birth. Total resection\\u000a was performed. Pathological

Daizo Yoshida; Yuichi Sugisaki; Toshiro Shimura; Akira Teramoto

1999-01-01

170

Bleeding duodenal hemangioma: Morphological changes and endoscopic mucosal resection  

PubMed Central

Recently, the development of endoscopic procedures has increased the availability of minimally invasive treatments; however, there have been few case reports of duodenal hemangioma treated by endoscopic mucosal resection. The present report describes a case of duodenal hemangioma that showed various endoscopic changes over time and was treated by endoscopic mucosal resection. An 80-year-old woman presented with tarry stools and a loss of appetite. An examination of her blood revealed severe anemia, and her hemoglobin level was 4.2 g/dL. An emergency upper gastrointestinal endoscopy was performed. A red, protrusive, semipedunculated tumor (approximately 20 mm in diameter) with spontaneous bleeding on its surface was found in the superior duodenal angle. Given the semipedunculated appearance of the tumor, it was suspected to be an epithelial tumor with a differential diagnosis of hyperplastic polyp. The biopsy results suggested a telangiectatic hemangioma. Because this lesion was considered to be responsible for her anemia, endoscopic mucosal resection was performed for diagnostic and treatment purposes after informed consent was obtained. A histopathological examination of the resected specimen revealed dilated and proliferated capillary lumens of various sizes, which confirmed the final diagnosis of duodenal hemangioma. Neither anemia nor tumor recurrence has been observed since the endoscopic mucosal resection (approximately 1 year). Duodenal hemangiomas can be treated endoscopically provided that sufficient consideration is given to all of the possible treatment strategies. Interestingly, duodenal hemangiomas show morphological changes that are influenced by various factors, such as mechanical stimuli.

Nishiyama, Noriko; Mori, Hirohito; Kobara, Hideki; Fujihara, Shintarou; Nomura, Takako; Kobayashi, Mitsuyoshi; Masaki, Tsutomu

2012-01-01

171

[Diagnostic imaging of hemangiomas in the brain].  

PubMed

In this study, we reviewed the findings of diagnostic imaging of cerebral vascular anomalies classified as cerebral cavernous malformation (CCM)/hemangioma, developmental venous anomalies (DVAs)/venous malformation (VM), and capillary telangiectasia. In addition, we described the imaging findings of cavernous sinus hemangioma and orbital hemangioma/vascular anomaly. CCM has 2 forms: a sporadic form characterized by isolated lesions and a familial form characterized by multiple lesions with an autosomal dominant mode of inheritance. Furthermore, CCMs are divided into 4 categories on the basis of magnetic resonance (MR) signal intensities on T1-, T2-, and gradient-echo (GRE) T2*-weighted images. In general, the lesion is hyper- or hypointense or has a core of reticulated signal intensity surrounded by a hypointense rim on conventional T2-weighted images. DVAs are characterized by the presence of a cluster of venous radicles that converge into a collecting vein, resulting in the typical caput medusae appearance of the lesion. Noncontrast T1- and T2-weighted images show flow voids and phase-shift artifact produced by the collecting vein of a DVA and by the large venous radicles of the caput medusae. Three-dimensional contrast-enhanced GRE T1-weighted imaging is useful for the assessment of morphological features of DVAs. In some cases, changes in parenchymal signal intensity within the drainage territory of the DVA are identified on T2-weighted image and fluid-attenuated inversion recovery (FLAIR) image. Capillary telangiectasias are small lesions and tend to appear as faintly hyperintense regions on T2-weighted image and faintly enhanced regions with a brush-like appearance. Results of susceptibility-weighted imaging (SWI) characteristically show this lesion as a hypointense mass. SWI is a novel imaging technique that exploits phase shifts to maximize sensitivity to differences between magnetic susceptibility between adjacent tissues. This technique is widely used with 3-T MR machines. SWI has improved the diagnosis of microbleeds, brain tumor, cerebrovascular disease, degenerative disease, etc. SWI is superior to GRE T2*-weighted imaging for determining hemosiderin, methohemoglobin, and deoxyhemoglobin contents. The sensitivity of SWI for determining the number of CCM lesions is significantly higher than that of GRE T2*-weighted imaging. PMID:21228443

Toyoda, Keiko; Oba, Hiroshi

2011-01-01

172

Proteomic analysis of pulmonary sclerosing hemangioma.  

PubMed

Sclerosing hemangioma (SH) is a rare benign pulmonary tumor derived from the primitive respiratory epithelium. However, the pathogenesis of SH has not yet been clear. Surfactant protein, thyroid transcription factor-1, epithelial membrane antigen, cytokeratin, and vimentin have been identified in SH by immunohistochemistry and electron microscopy. To identify proteins specifically regulated in SH, 2-D PAGE was performed using SH and paired normal tissues. Ten selected differentially expressed protein spots were identified by PMF, MALDI-TOF-MS, and database searching. Apolipoprotein A-1, antizyme inhibitor, heat shock 27-kDa protein 1, and antioxidant proteins, such as peroxiredoxin II (Prx II) and GST, were identified among the down-regulated proteins in SH. Western blot and immunohistochemistry confirmed reduced expressions of Prx II and GST in SH versus normal lung tissue. This study is the first report on the reduced expressions of Prx II and GST in SH. PMID:16892484

Jin, Lian-Jin; Shin, Bong Kyung; Jung, Woon Yong; Lee, Hyun-Juu; Cho, Su Jin; Han, Joung-Ho; Ha, Seong-Yeon; Kim, Ae-Ree; Sik Kim, Young; Sun Kim, In; Uhm, Chang-Sub; Kim, Han Kyeom

2006-09-01

173

Surgical management of large scalp infantile hemangiomas  

PubMed Central

Background: Infantile Hemangiomas (IH) are the most common benign tumor of infancy, occurring in over 10% of newborns. While most IHs involute and never require intervention, some scalp IHs may cause severe cosmetic deformity and threaten tissue integrity that requires surgical excision. Case Description: We present our experience with two infants who presented with large scalp IH. After vascular imaging, the patients underwent surgical resection of the IH and primary wound closure with excellent cosmetic outcome. We detail the surgical management of these cases and review the relevant literature. Conclusion: In some cases the IHs leave behind fibro-fatty residuum causing contour deformity. Surgery is often required for very large lesions causing extensive anatomical and/or functional disruption. The goal of surgical intervention is to restore normal anatomic contour and shape while minimizing the size of the permanent scar.

Khan, Imad S.; Kiehna, Erin N.; Satti, Komal F.; Ehtesham, Moneeb; Ghiassi, Mahan; Singer, Robert J.

2014-01-01

174

[Intramuscular epithelioid hemangioma of the parapharyngeal space].  

PubMed

A clinical case of epithelioid hemangioma of the scalene muscle that occupied the parapharyngeal space is reported. The patient was a 34 year old man with a 2-month history of sensation of pharyngeal foreign body and mild dysphagia. The exploration revealed a tumor of the posterior and lateral wall of the oropharynx that extended from the rhinopharynx to the hypopharynx. The diagnostic sequence included CT, MRI, Doppler echography, and arteriography, which identified a right post-styloid tumor located behind and medial to the jugular vein, internal carotid artery, and vagal nerve, but did not affect arterial blood flow. The patient underwent surgical treatment consisting of lateral cervicotomy, tumor excision, and histological study. PMID:10217694

Santaolalla Montoya, F; Zabala López de Maturana, A; Martínez Ibargüen, A; Mohamed Rammal, A; Sán-chez del Rey, A; Ereño Zárate, C

1999-03-01

175

[Radiologic evaluation of an isolated vertebral hemangioma].  

PubMed

CT scan and M.R.I. features have been evaluated in case of compressive (H.V.C.) and asymptomatic (H.V.A.) vertebral hemangiomas. The main datas observed in H.V.C. are: 1) thoracic localization; 2) whole vertebral body involvement; 3) extension to the pedicles; 4) irregular trabeculation; 5) swelling of bone contours with 6) epidural and perivertebral extension. H.V.C. always exhibit at least three of these six datas while H.V.A. are associated with 2 or less. Also H.V.C. frequently present intravertebral contrast enhancement on CT and low signal intensity on T1 weighted and high signal intensity on T2 weighted M.R.I. PMID:2698449

Laredo, J D; Assouline, E; Gaston, A; Gelbert, F; Merland, J J

1989-01-01

176

Unusual splenic hemangioma of a pediatric patient: hypointense on T2-weighted image.  

PubMed

Splenic hemangioma is a very rare neoplasm in children. On magnetic resonance imaging, splenic hemangioma shows high signal intensity on T2-weighted images. In this report, we present the first pediatric case of a splenic hemangioma, which was significantly hypointense on T2-weighted images. PMID:24667046

Ozcan, Hatice Nursun; Oguz, Berna; Talim, Beril; Ekinci, Saniye; Haliloglu, Mithat

2014-01-01

177

Ultrasonographically guided injection of corticosteroids for the treatment of retroseptal capillary hemangiomas in infants  

Microsoft Academic Search

Purpose: Injection of corticosteroids is a well-documented and successful mode of treatment for periorbital capillary hemangiomas. Because of the greater potential risk involved with retrobulbar injections, no prior study has described this treatment for tumors located behind the orbital septum. Although retroseptal intraorbital capillary hemangiomas comprise only 7% of all adnexal capillary hemangiomas, complications such as optic nerve compression or

Doron Neumann; Sherwin J. Isenberg; Arthur L. Rosenbaum; Robert A. Goldberg; Veronique H. Jotterand

1997-01-01

178

Lobular capillary hemangiomas: An epidemiologic report, with emphasis on cutaneous lesions  

Microsoft Academic Search

Background: Lobular capillary hemangiomas (pyogenic granulomas) occur on both mucosal and cutaneous surfaces. There are conflicting data regarding the increased prevalence of lobular capillary hemangiomas in female versus male subjects. Some studies have noted a female predominance of lobular capillary hemangiomas, but other studies do not reveal such a disparity. Because of an increased prevalence during pregnancy, oral tumors are

M. N. Harris; R. Desai; T.-Y. Chuang; A. F. Hood; G. W. Mirowski

2000-01-01

179

Transconjunctival approach for retrobulbar intraconal orbital cavernous hemangiomas. Orbital surgeon's perspective  

Microsoft Academic Search

BackgroundCavernous hemangioma is the most common benign intraorbital tumor found in adults. Most cavernous hemangiomas are located within the intraconal space. When indicated, complete surgical removal is the only treatment option. Several surgical techniques have been refined over the past decades. We describe our experience over transconjunctival approach in 24 patients with retrobulbar intraconal orbital cavernous hemangiomas.

Hayyam K?ratl?; Burçin Bulur; Sevgül Bilgiç

2005-01-01

180

Hepatic vascular anomalies in infancy: A twenty-seven-year experience  

Microsoft Academic Search

OBJECTIVE: Infantile hemangioma and arteriovenous malformation (AVM) of the liver have a similar presentation but a different natural history, and therefore require different treatment. This study was undertaken to clarify differential diagnosis and management of these two biologically distinct vascular disorders. STUDY DESIGN: We retrospectively analyzed the records of 43 children with hepatic vascular anomalies treated during the past 27

Laurence M. Boon; Patricia E. Burrows; Harriet J. Paltiel; Dennis P. Lund; R. Alan B. Ezekowitz; Judah Folkman; John B. Mulliken

1996-01-01

181

Transpupillary thermotherapy in the management of circumscribed choroidal hemangioma.  

PubMed

Laser photocoagulation and various radiation therapy methods have been used in the treatment of circumscribed choroidal hemangioma that produce visual loss. Recently, transpupillary thermotherapy has been employed in the management of choroidal hemangioma. Thirty-six cases of choroidal hemangioma treated with transpupillary thermotherapy are reviewed. Twenty-eight cases were reported in the literature and 10 cases were managed by the author. Transpupillary thermotherapy has been used as a primary treatment (36 cases) or secondary treatment (2 cases) for choroidal hemangioma. The goal of transpupillary thermotherapy is to achieve resolution of exudative detachment of the fovea and improvement of vision. In all eyes the foveal detachment subsided. In 26 eyes having pretreatment visual acuity >or=0.05 (20/400), the visual acuity increased in 20 (77%) eyes and remained unchanged in 6 (23%) eyes. After transpupillary thermotherapy, 16 (42%) cases showed complete regression, 20 (53%) demonstrated partial regression, and in 2 (5%) there was no change in tumor thickness at follow-ups ranging from 2 to 44 months. Complications of transpupillary thermotherapy of choroidal hemangioma included cystoid macular edema (3 eyes), preretinal fibrosis (2 eyes), focal iris atrophy (3 eyes), and retinal vascular occlusion (1 eye). Although the follow-up in many studies is limited, transpupillary thermotherapy has not been associated with any significant complications. PMID:15110668

Gündüz, Kaan

2004-01-01

182

A rare cavernous hemangioma of the adrenal gland?  

PubMed Central

INTRODUCTION Cavernous hemangiomas of the adrenal gland are rare. We report a case of a cavernous hemangioma of the adrenal gland presenting as an adrenal incidentaloma suspicious for adrenal cortical carcinoma (ACC). PRESENTATION OF CASE A 78 year old woman was admitted after a fall. Abdominal computed tomography revealed a large right adrenal lesion with features suspicious for adrenal cortical carcinoma (5.4 cm × 3.3 cm, unilateral, tumor calcifications, average Hounsfield units 55). The tumor was removed intact by a laparoscopic approach and pathology revealed a cavernous hemangioma of the adrenal gland. DISCUSSION Adrenal incidentalomas are found in up to 10% of patients undergoing abdominal imaging. Differential diagnosis includes both benign and malignant lesions. Guidelines for removal of adrenal incidentalomas recommend surgery based on functional status, size, and presence of concerning features on diagnostic imaging. Cavernous hemangiomas are rare, benign vascular malformations which can be challenging to distinguish pre-operatively from malignant lesions such as ACC. CONCLUSION Cavernous hemangiomas of the adrenal gland are exceedingly rare. These benign tumors have imaging features which may be suggestive of adrenal cortical carcinoma. The treatment of choice is surgical excision due the difficulty of excluding malignancy.

Edwards, Janet P.; Stuart, Heather C.; Urbanski, Stefan J.; Pasieka, Janice L.

2013-01-01

183

Periosteal spindle cell hemangioma of the fibula: a case report.  

PubMed

Spindle cell hemangioma is a rare benign tumor characterized by cavernous blood vessels and spindle cell proliferation. It typically arises in the subcutis of the distal extremities, particularly in the hand. Spindle cell hemangioma of periosteal origin is extremely rare, and our extensive literature search did not find any reports of this condition. We report here a case of spindle cell hemangioma of periosteal origin arising from the right fibula of a 49-year-old woman. Pathological examination of a needle biopsy specimen indicated the possibility of low-grade spindle cell sarcoma, and the patient underwent resection of the fibular diaphysis with a wide margin. Subsequent examination of the surgical specimen revealed a diagnosis of periosteal spindle cell hemangioma. Follow-up examination at 10 months showed no evidence of local recurrence or metastasis. A large tissue sample was required for definitive diagnosis in this case. Spindle cell hemangioma behaves in a benign fashion, but recurrence occurs in about 60% of cases. Excision of the fibula was a reasonable course of management in this case because these patients usually maintain good function. Reports of additional cases will be required to determine the most appropriate treatment for this tumor. PMID:23525489

Tsukamoto, Shinji; Honoki, Kanya; Shimada, Keiji; Fujii, Hiromasa; Kido, Akira; Takano, Masato; Enomoto, Yasunori; Kasai, Takahiko; Konishi, Noboru; Tanaka, Yasuhito

2013-08-01

184

Periocular capillary hemangioma: management practices in recent years  

PubMed Central

Purpose To present a case series on the management options for capillary hemangiomas involving the eyelid and orbit. Methods This is a retrospective chart review of clinically diagnosed capillary hemangioma cases involving the periocular region treated at two local eye institutions. The patients’ demographics and clinical presentation – including visual acuity, refractive error, periorbital and orbital examinations, and ultrasound and magnetic resonance imaging findings – were reviewed. The clinical progression, modalities of treatment, and treatment outcomes were studied. Results Sixteen cases of capillary hemangiomas involving the eyelid and orbit were studied. The mean age at consultation was 9.6 months (range: 1 month–72 months). The majority were females (75%), with 50% presenting as upper-eyelid hemangiomas and the remaining as lower-eyelid (38%) and glabellar (12%) lesions. Combined superficial and deep involvement was common (64%). Cases whose lesions were located at the upper eyelid or superior orbit led to amblyopia (25%). Fifty-six percent of cases (9/16) were managed conservatively, and 44% (7/16) underwent treatment with either single-agent (n = 4) or combined treatments (n = 3). Conclusion Close monitoring of visual development and prompt institution of amblyopia therapy for children with periocular capillary hemangiomas generally preserve vision. Extensive lesions that affect the visual axis require local and systemic treatments, alone or in combination, in order to reduce the size and impact of lesions on the eyeball, to reduce induced refractive error and visual occlusion, and to prevent the development of amblyopia, in order to achieve good visual outcomes.

Hernandez, Jo Anne; Chia, Audrey; Quah, Boon Long; Seah, Lay Leng

2013-01-01

185

Laser statistical polarimetry optical anisotropy of blood plasma of the patients with hemangioma  

NASA Astrophysics Data System (ADS)

Proposed in this work is a novel method of early laser polarimetric diagnostics of vessels pathologies and hemangioma formation. The generalized model of formation processes of polarization inhomogeneous laser images of experimental samples of biological tissues is presented. It was performed the experimental measurements of polarization states of both biological tissues laser images points and the hemangioma liquids. The results of investigating the interrelation between statistical moments of the 1st-4th order are presented that characterize the coordinate distributions of polarization azimuth of laser images of histological sections of hemangioma, hemangioma blood smears and blood plasma with vascular system pathologies. The diagnostic criteria of hemangioma nascency are determined.

Boychuk, T. M.; Bodnar, B. M.; Vatamanesku, L. I.

2011-09-01

186

An aggressive vertebral hemangioma in pregnancy: a case report  

PubMed Central

Introduction Pregnancy-related compressive myelopathy secondary to vertebral hemangioma is a rare occurrence and its treatment antepartum is rare. Case presentation A 19-year-old North African woman in her 38th week of pregnancy presented with paraplegia that progressed within 2 days after a rapidly progressive weakness of her lower limbs. Magnetic resonance imaging studies showed compression of her spinal cord in front of the fourth thoracic vertebra for suspected tuberculous spondylitis. A Caesarean section was done followed by corpectomy with a bone graft because we intraoperatively discovered a vertebral hemangioma. Pathology showed an aggressive hemangioma. Conclusion At any term of pregnancy, extensive neurological involvement which is rapidly progressive due to compression should be considered for immediate decompression.

2014-01-01

187

A Case of Calvarial Hemangioma in Cranioplasty Site  

PubMed Central

It is not uncommon for hemangiomas to occur in the calvarium, accounting for about 10% of the benign skull tumors. A 46-year-old man was presented with a palpable scalp mass on the left parietal region. Past medical history indicated that he had undergone cranioplasty 25 years prior due to a depressed skull fracture suffered from a traffic accident. Magnetic resonance imaging revealed mixed signal intensity mass on T1 -and T2-weighted images pushing a linear signal void lesion outward in the left parietal region. After total surgical removal along with cranioplasty, he was discharged without neurological deficits. Histological examination of the surgical specimen revealed a cavernous hemangioma. A skull hemangioma occurring at the site of a cranioplasty has not yet been reported. Therefore, authors report this case in combination with a pertinent literature review.

Kang, Dong Wan

2009-01-01

188

[Endobronchial capillary hemangioma: a very rare cause of massive hemoptysis].  

PubMed

Tracheal capillary hemangioma is a very rare benign tumor of trachea which may present as massive hemoptysis. Minor to massive hemoptysis can be observed in these patients. Due to its small size and tracheal localization, diagnosis cannot be easily performed by using radiological investigations. Fifty-years-old male patient who was diagnosed as tracheal capillary hemangioma with bronchoscopic biopsy was presented in this case report. According to our knowledge, this is the eighth case report in the world literature. Tracheal capillary hemangioma must be kept in mind in patients with massive hemoptysis with normal radiologic features and bronchoscopic procedures (excision, argon, laser etc.) should be the first choice of therapy when diagnosed. PMID:22554374

Özy?lmaz, Ezgi; Yunsel, Dilek; Hanta, ?smail; Kuleci, Sedat; Kocaba?, Ali

2012-01-01

189

Capillary hemangioma of cauda equina: a case report  

PubMed Central

Background Capillary hemangiomas of spinal nerve root, mostly affecting the cauda equina, are extremely rare. Case presentation A 20-year old man was presented with back pain, radiculopathy, and urogenital symptoms. Magnetic resonance images revealed an intradural extramedullary mass, isointense in T1-weighted and hyperintense in T2-weighted images, with noticeable post injection enhancement. The clinical and radiological findings simulated neurinoma. However, a pinkish lesion was removed surgically and histopathological examination revealed lobules of capillary vessels separated by fibrous tissue, suggesting capillary hemangioma. Conclusion Although rare and sometimes indistinguishable from more common lesion, capillary hemangioma should be in differential diagnosis of any enhancing intradural extramedullary mass at the level of cauda equina or conus medullaris.

2009-01-01

190

Oral Propranolol for Treatment of Pediatric Capillary Hemangiomas  

PubMed Central

Purpose To report the long-term results of treatment of pediatric capillary hemangiomas with oral propranolol. Methods Three infants, 3 to 4 months of age, with periocular capillary hemangiomas were treated with oral propranolol solution (Inderal, 20mg/5ml) 2-3 mg/kg per day divided in 2 doses. Propranolol was continued up to the end of the first year of life and tapered over 2-3 weeks. All infants were followed for 20 months. Lesion size and evolution were assessed during the follow-up period. Results Significant improvement was noted in all patients in the first 2 months of therapy with slow and continuous effect throughout the follow-up period. No serious complications were observed. Conclusion Oral propranolol can be used as a first line agent in children with capillary hemangiomas.

Aletaha, Maryam; Salour, Hossein; Bagheri, Abbas; Raffati, Nasrin; Amouhashemi, Nassim

2012-01-01

191

Symptomatic hemangioma of oral cavity treated with CO2 laser  

NASA Astrophysics Data System (ADS)

The CO2 laser has been used by our group as a secure and efficient tool for the treatment of symptomatic oral cavity hemangiomas which can be responsible for disturbance for swallowing, phonation and in hygienic, besides discomfort and bleeding to patients. During the last four years, twelve patients with symptomatic oral cavity hemangioma were treated at the Laser Unit of our University. The treatment consisted in the application of CO2 laser at medium to low intensity according to characteristics and location of the lesions. For hemangiomas located at sites of easy surgical access such as anterior 1/3 of the tongue, lips, bucal vestibule we use 10 to 37 J/mm2 over the surface of the lesion. When the hemangioma was located at difficult surgical access sites, such as, tonsils, posterior 1/3 of tongue, or at pharyngeal wall we used 3.0 to 4.0 J/mm2 encircling the whole hemangioma. This causes reduction in the size of the lesion throughout sclerosis of nutrition vessels. After this initial procedure we applied 0.8 to 1.0 J/mm2 over the whole extent of the lesion. For both procedures we observed no significant bleeding or inflammatory reaction. The patients referred minimal post-operative discomfort with good cicatricial evolution. The evident reduction in the vascularization and size could be confirmed by photographic documentation. The good results described above, with disappearance of symptoms lead to the conclusion that CO2 laser is an efficient and secure method of treatment for symptomatic hemangioma of the oral cavity.

Nicola, Ester M.; Coutinho, Adriana A.; Nicola, Jorge H.; Gusmao, Reinaldo J.

1995-05-01

192

Photodynamic therapy for retinal capillary hemangioma  

PubMed Central

Purpose To describe the results of photodynamic therapy (PDT) for juxtapapillary and peripheral retinal capillary hemangioma (RCH). Patients and methods Interventional case series of four eyes (four patients) with juxtapapillary RCH and one eye (one patient) with peripheral RCH. Two eyes with juxtapapillary RCH had received two sessions of full-fluence, double-duration PDT; whereas other two eyes had received single session of half-fluence, single-duration PDT. The peripheral RCH was treated with a single session of full-fluence, single-duration PDT. Results Two patients had von Hippel–Lindau disease. Follow-up duration ranged from 4 months to 1 year. Pre-PDT visual acuity (VA) ranged from 20/200 to HM (juxtapapillary RCH) and 20/100 (peripheral RCH). Among the eyes with juxtapapillary RCH, tumor regression with partial resolution of macular edema was noted in two eyes (one eye each with half-fluence and full-fluence PDT), whereas two eyes had no change in tumor size with persistent macular edema. VA remained stable in three eyes and declined in one eye. In an eye with peripheral RCH, regression of tumor and macular edema with VA improvement was noted. Post-PDT complications included epiretinal membrane (one eye) and transient exudative retinal detachment (one eye). Conclusion PDT can be effective in reducing macular edema associated with RCH but this does not always correspond with an improvement in VA especially for juxtapapillary tumors.

Papastefanou, V P; Pilli, S; Stinghe, A; Lotery, A J; Cohen, V M L

2013-01-01

193

Role of connexins in infantile hemangiomas  

PubMed Central

The circulatory system is one of the first systems that develops during embryogenesis. Angiogenesis describes the formation of blood vessels as a part of the circulatory system and is essential for organ growth in embryogenesis as well as repair in adulthood. A dysregulation of vessel growth contributes to the pathogenesis of many disorders. Thus, an imbalance between pro- and antiangiogenic factors could be observed in infantile hemangioma (IH). IH is the most common benign tumor during infancy, which appears during the first month of life. These vascular tumors are characterized by rapid proliferation and subsequently slower involution. Most IHs regress spontaneously, but in some cases they cause disfigurement and systemic complications, which requires immediate treatment. Recently, a therapeutic effect of propranolol on IH has been demonstrated. Hence, this non-selective ?-blocker became the first-line therapy for IH. Over the last years, our understanding of the underlying mechanisms of IH has been improved and possible mechanisms of action of propranolol in IH have postulated. Previous studies revealed that gap junction proteins, the connexins (Cx), might also play a role in the pathogenesis of IH. Therefore, affecting gap junctional intercellular communication is suggested as a novel therapeutic target of propranolol in IH. In this review we summarize the current knowledge of the molecular processes, leading to IH and provide new insights of how Cxs might be involved in the development of these vascular tumors.

Blanke, Katja; Dahnert, Ingo; Salameh, Aida

2013-01-01

194

Gamma Knife Radiosurgery for Choroidal Hemangioma  

SciTech Connect

Purpose: Patients with choroidal hemangioma (CH), a benign ocular hamartoma, frequently presents with visual disturbance as a result of exudative retinal detachment (RD), which originates in subretinal fluid accumulation. We report our experience using the Leksell Gamma Knife in the management of symptomatic CH. Methods and Materials: Seven patients with symptomatic CH (circumscribed form in 3 patients and diffuse form in 4) were treated with the Leksell Gamma Knife at our institution during a 7-year period. All patients presented with exudative RD involving the macula that resulted in severe visual deterioration. The prescription dose to the target margin was 10 Gy in all cases. The mean tumor volume receiving the prescription dose was 536 mm{sup 3} (range, 151-1,057). The clinical data were analyzed in a retrospective fashion after a mean follow-up of 34.4 months (range, 9-76). Results: The resolution of exudative RD was achieved within 6 months, and the visual acuity of the affected eye had improved at the latest follow-up examination (p = .018) in all patients. No recurrence of exudative RD occurred. Thinning of the CHs was observed in most patients; however, symptomatic radiation toxicity had not developed in any of the patients. Conclusion: Symptomatic CHs can be safely and effectively managed with Gamma Knife radiosurgery using a marginal dose of 10 Gy.

Kim, Yun Taek; Kang, Se Woong [Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of); Lee, Jung-Il, E-mail: jilee@skku.edu [Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of)

2011-12-01

195

An unusual cause of paraphimosis: hemangioma of the glans penis.  

PubMed

Paraphimosis is a urologic emergency that occurs in uncircumcised boys. In untreated paraphimosis, increasing edema caused by vascular and lymphatic obstruction results in ominous sequelae such as penile gangrene, which leads to autoamputation in days or weeks. Most cases of paraphimosis are iatrogenic, but that condition has unusual causes as well. We present a very rare case of paraphimosis that occurred in a patient with a hemangioma of the glans penis. We suggest that the swelling of the hemangioma pushed the penile skin backward and caused paraphimosis. To our knowledge, such a presentation has not been previously reported in the English literature. PMID:18280267

Yi?iter, Murat; Arda, Irfan Serdar; Hiçsönmez, Akgün

2008-02-01

196

[Primary hepatic infantile hemangioendothelioma (author's transl)].  

PubMed

Primary hepatic infantile hemangioendothelioma is a rare tumor, characterized by its appearance in early infancy as well as by the frequent association with various malformations and with similar angiomatous tumors of other tissues and organs. It may be single or multinodular and it is often complicated by severe peritoneal hemorrhage. Tow histologic types of this tumor are known: tipe 1 is sharply circumscribed and is considered similar to so called capillary hypertrophic hemangioma, while type 2, by showing aggressive, infiltrative and anaplastic features, is rather close to angiosarcoma. Clinical and pathological data concerning two cases of type 2 primary hepatic infantile hemangioendothelioma are reported. On the basis of experimental results and epidemiological data on hepatic angiosarcoma of adults, a possible etiopathogenetic relationship with maternal exposure during pregnancy to dangerous environmental factors is postulated. PMID:1224398

Pollice, L; Pagliarulo, G

1975-01-01

197

Differential Diagnosis of Hepatic Tumors: Value of Contrast-Enhanced Harmonic Sonography Using the Newly Developed Contrast Agent, Sonazoid  

Microsoft Academic Search

Objective: To clarify the value of contrast-enhanced harmonic ultrasonography (US) with Sonazoid, a second-generation US contrast agent, in the differential diagnosis of liver tumors compared to dynamic CT. Methods: A total of 249 hepatic nodules in 214 patients were studied; these included 177 hepatocellular carcinomas (HCCs), 42 liver metastases, 20 liver hemangiomas, 6 dysplastic nodules and 4 focal nodular hyperplasias

Kinuyo Hatanaka; Masatoshi Kudo; Yasunori Minami; Taisuke Ueda; Chie Tatsumi; Satoshi Kitai; Shunsuke Takahashi; Tatsuo Inoue; Satoru Hagiwara; Hobyung Chung; Kazuomi Ueshima; Kiyoshi Maekawa

2008-01-01

198

Thoracic outlet syndrome caused by first rib hemangioma  

Microsoft Academic Search

We report a case of first rib hemangioma that caused thoracic outlet syndrome. A 50-year-ole woman who was admitted to our hospital with a clinical diagnosis of thoracic outlet syndrome presented with fullness and easy fatigue of her right arm. Her right arm discomfort was associated with intermittent engorgement of superficial veins over the shoulder girdle. A chest radiograph revealed

Kee-Min Yeow; Hung-Chang Hsieh

2001-01-01

199

Synovial Hemangioma of the Knee Joint: a case report  

Microsoft Academic Search

Synovial hemangioma is a rare benign tumor, yet an important cause of knee symptoms. We repor ted a 45 -year- old male pre sented w ith pain and swelling in the left knee joint. Plain radiography showed a small calcif ication over the suprapatellar region. Sonography of left knee revealed a heterogeneously hypoechoic lesion with increased blood f low and

Wen-sHeng Tzeng; Kaohsiung Armed; E-Da Hospital; Shu Zen; Lee-Ren Yeh

2008-01-01

200

Dynamic CT features of mediastinal hemangioma: more information for evaluation  

Microsoft Academic Search

Dynamic enhancing feature in mediastinal hemangioma was rarely reported. Slow, gradually increasing and prolonged contrast stains are the diagnostic hints in our case that avoid the hemorrhagic catastrophe from transthoracic core needle biopsy. A rare finding of an aberrant vessel entering into the tumor was valuable for operative planning. Dynamic computed tomography (CT) can provide more information for evaluation in

Yun-Chung Cheung; Shu-Hang Ng; Yung-Liang Wan; Chih-Feng Tan; Ho-Fai Wong; Koon-Kwan Ng

2000-01-01

201

CT, angiography, and RN scans in intracranial cavernous hemangiomas  

Microsoft Academic Search

Nine cases of surgically verified intracranial cavernous hemangiomas are reported. A comparison is made between radionuclide brain scans, angiography, and CT studies: RN scans are sometimes superior to angiography in indicating the presence of the lesion; CT is the most informative investigation, although it does not present a specific pattern. A preoperative specific diagnosis can only be suggested on the

M. Savoiardo; A. Passerini

1978-01-01

202

Cavernous hemangiomas in the cavernous sinus. Case reports  

Microsoft Academic Search

BACKGROUNDExtra-axial cavernous hemangiomas are rare and have a propensity to develop within the cavernous sinus. Total removal of these vascular tumors is difficult due to the risk of severe intraoperative bleeding and the complicated neurovascular structures of the cavernous sinus. Only a small number of cases have been reported to be successfully totally removed.METHODSRetrospective studies were done in three cases

Jixin Shi; Handong Wang; Chunhua Hang; Yunxi Pan; Chenji Liu; Zuxuan Zhang

1999-01-01

203

Concomitant Cavernous Hemangioma and Venous Angioma of the Orbit  

Microsoft Academic Search

Background An unusual case of cavernous hemangioma coexisting with venous angioma in the ipsilateral orbit is described. Case A 67-year-old woman had a mass in the lower eyelid of her right eye and proptosis. Imaging examinations showed two masses connected to each other in the extraconal space of the right orbit. Observations Anterior orbitotomy was performed to remove the tumors.

Tatsuo Kodama; Nobuhiro Tane; Akihiro Ohira; Yotaro Matsuoka; Riruke Maruyama

2004-01-01

204

Orbital cavernous hemangiomas: ultrasound and magnetic resonance imaging evaluation.  

PubMed

Cavernous hemangioma is the most common intraorbital lesion in adults. The aim of our study was to evaluate the magnetic resonance imaging (MRI) and ultrasound (US) characteristics of cavernous hemangioma and their role in the differential diagnosis of orbital tumors. Eight patients with orbital cavernous hemangiomas, five women and three men with a mean age of 48 years were examined in a period of six years. All patients underwent MRI examination and four patients were also evaluated by US. In all cases MRI depicted a well-defined intraconal tumor. The lesions were homogeneous, isointense to muscle on T1-weighted sequence and hyperintense to muscle on T2-weighted sequence in six patients. In one patient the mass was isointense on T1WI with heterogeneous signal intensity on T2WI and in one patient the lesion had heterogeneous signal intensity on both T1- and T2-weighted sequences. After intravenous contrast medium administration, the tumors showed initial inhomogeneous enhancement with progressive accumulation of contrast material on delayed images in seven patients and initial homogeneous enhancement in one patient. On ultrasonography, the orbital masses appeared slightly hyperechoic, heterogeneous with small areas of slow blood flow. The analysis of imaging characteristics of a well-defined intraconal lesion in an adult patient with painless progressive proptosis can be highly suggestive of the diagnosis of cavernous hemangioma. PMID:24148341

Diamantopoulou, A; Damianidis, Ch; Kyriakou, V; Kotziamani, N; Emmanouilidou, M; Goutsaridou, F; Tsitouridis, I

2010-03-01

205

Acute presentation of cavernous hemangioma of the orbit.  

PubMed

Cavernous hemangioma of the orbit typically presents as a slow-growing tumor with gradual onset of symptoms. Acute onset of clinical signs and symptoms, are a rare feature. We present the case of a 40-year-old female, who developed sudden onset of clinical symptoms. MRI evidence of intralesional hemorrhage was confirmed by histopathology. PMID:21780934

Arora, Vipul; Prat, Marta Calsina; Kazim, Michael

2011-08-01

206

Boundary giant magnons and giant gravitons  

NASA Astrophysics Data System (ADS)

We construct the full set of boundary giant magnons on mathbb{R} × {S^2} attached to the maximal Z = 0 giant graviton by mapping from the general solution to static sine-Gordon theory on the interval and compute the values of ? - J at finite J, including the leading order corrections when J is large. We then consider the Born-Infeld theory of the giant graviton itself to construct BIon spike solutions that correspond to the world volume description of the boundary giant magnons at finite J.

Ciavarella, A.; Bowcock, P.

2010-09-01

207

High-Resolution Micro-CT for Morphologic and Quantitative Assessment of the Sinusoid in Human Cavernous Hemangioma of the Liver  

PubMed Central

Hepatic sinusoid plays a vital role in human cavernous hemangioma of the liver (CHL), and its morphologic investigation facilitates the understanding of microcirculation mechanism and pathological change of CHL. However, precise anatomical view of the hepatic sinusoid has been limited by the resolution and contrast available from existing imaging techniques. While liver biopsy has traditionally been the reliable method for the assessment of hepatic sinusoids, the invasiveness and sampling error are its inherent limitations. In this study, imaging of CHL samples was performed using in-line phase-contrast imaging (ILPCI) technique with synchrotron radiation. ILPCI allowed clear visualization of soft tissues and revealed structural details that were invisible to conventional radiography. Combining the computed tomography (CT) technique, ILPCI-CT was used to acquire the high-resolution micro-CT images of CHL, and three dimensional (3D) microstructures of hepatic sinusoids were provided for the morphologic depiction and quantitative assessment. Our study demonstrated that ILPCI-CT could substantially improve the radiographic contrast of CHL tissues in vitro with no contrast agent. ILPCI-CT yielded high-resolution micro-CT image of CHL sample at the micron scale, corresponding to information on actual structures revealed at histological section. The 3D visualization provided an excellent view of the hepatic sinusoid. The accurate view of individual hepatic sinusoid was achieved. The valuable morphological parameters of hepatic sinusoids, such as thrombi, diameters, surface areas and volumes, were measured. These parameters were of great importance in the evaluation of CHL, and they provided quantitative descriptors that characterized anatomical properties and pathological features of hepatic sinusoids. The results highlight the high degree of sensitivity of the ILPCI-CT technique and demonstrate the feasibility of accurate visualization of hepatic sinusoids. Moreover, there is a correlation between the CHL and the size or morphology of hepatic sinusoids, which offers a potential use in noninvasive study and analysis of CHL.

Duan, Jinghao; Hu, Chunhong; Chen, Hua

2013-01-01

208

Pulmonary Hemangiomas of Infancy and Childhood: Report of Two Cases and Review of the Literature  

Microsoft Academic Search

Pulmonary hemangiomas are exceptionally rare in childhood and more so in infancy. They may involve the airways or the parenchyma,\\u000a and may be localized or multifocal. We present two cases of pulmonary capillary hemangiomas. The first case is a localized\\u000a form of capillary hemangioma that was resected from an 8-week-old infant with signs of respiratory distress. A computed tomography\\u000a scan

Neil A. Abrahams; Thomas V. Colby; Richard H. Pearl; Bradley E. Chipps; Andrew L. Juris; Kevin O. Leslie

2002-01-01

209

Cavernous hemangioma of the kidney: A report of two cases and review of the literature  

PubMed Central

Hemangioma of kidney is a rare benign tumor. Although it may be clinically silent, their main symptom is hematuria, sometimes profuse and relapsing. We report two such cases which presented with episodes of hematuria and were clinically and radiologically diagnosed as transitional cell carcinoma. Nephrectomy was performed in both cases and the histopathological appearance were those of a cavernous hemangioma. A literature review of renal hemangioma is also presented.

Sethi, Somika; Agarwal, Vikash; Chopra, Prem

2012-01-01

210

Sternal Cleft associated with Patent Ductus Arteriosus, Atrial Septal Defect, and Subglottic Hemangioma: A rarity  

PubMed Central

We present a 2-day-old female neonate with cleft of the upper sternum, patent ductus arteriosus (PDA), atrial septal defect (ASD), and subglottic hemangioma. Dimensional and Doppler echocardiography, abdominal ultrasonography, and imaging were performed. She underwent a surgical repair of sternal cleft in neonatal life. After 8 months, she developed respiratory distress, apnea due to subglottic hemangioma. She underwent urgent tracheostomy. Subglottic hemangioma was treated with the KTP532 laser.

Mirshemirani, Alireza; Sadeghian, Irandokht

2014-01-01

211

Hemangioma of the prostate - an unusual cause of lower urinary tract symptoms: Case report  

Microsoft Academic Search

Background  Hemangioma of the prostate gland is extremely rare and only a few cases have been reported. There have been several cases\\u000a of hemangioma of posterior urethra, urinary bladder and periprostatic plexus in the literature, all presenting with hematuria\\u000a or hematospermia. Diagnosis of prostatic hemangioma is difficult due to its rarity and unspecific symptoms such as hematuria,\\u000a hematospermia or lower urinary

Reza R Serizawa; Nis Nørgaard; Thomas Horn; Henrik Vibits

2011-01-01

212

Giant Cell Arteritis  

MedlinePLUS

... by prompt diagnosis and treatment. What is giant cell arteritis? GCA is a type of vasculitis or ... right away to their doctors. What causes giant cell arteritis? As with PMR, the cause of GCA ...

213

Giant Cell Arteritis  

MedlinePLUS

Giant cell arteritis is a disorder that causes inflammation of arteries of the scalp, neck, and arms. It narrows ... arteries, which keeps blood from flowing well. Giant cell arteritis often occurs with another disorder called polymyalgia ...

214

Rapamycin Suppresses Self-Renewal and Vasculogenic Potential of Stem Cells Isolated from Infantile Hemangioma  

PubMed Central

Infantile hemangioma (IH) is a common childhood vascular tumor. Although benign, some hemangiomas cause deformation and destruction of features or endanger life. The current treatments, corticosteroid or propranolol, are administered for several months and can have adverse effects for the infant. We designed a high-throughput screen to identify FDA-approved drugs that could be used to treat this tumor. Rapamycin, an mTOR inhibitor, was identified based on its ability to inhibit proliferation of a hemangioma-derived stem cell population, human vasculogenic cells we had previously discovered. In vitro and in vivo studies show that Rapamycin reduces the self-renewal capacity of the hemangioma stem cells, diminishes differentiation potential, and inhibits the vasculogenic activity of these cells in vivo. Longitudinal in vivo imaging of blood flow through vessels formed with hemangioma stem cells shows that Rapamycin also leads to regression of hemangioma blood vessels, consistent with its known anti-angiogenic activity. Finally, we demonstrate that Rapamycin-induced loss of stemness can work in concert with corticosteroid, the current standard therapy for problematic hemangioma, to block hemangioma formation in vivo. Our studies reveal that Rapamycin targets the self-renewal and vascular differentiation potential in patient-derived hemangioma stem cells and suggests a novel therapeutic strategy to prevent formation of this disfiguring and endangering childhood tumor.

Greenberger, Shoshana; Yuan, Siming; Walsh, Logan A.; Boscolo, Elisa; Kang, Kyu-Tae; Matthews, Benjamin; Mulliken, John B.; Bischoff, Joyce

2011-01-01

215

Intraosseous spindle cell hemangioma of the calcaneus: a case report and review of the literature.  

PubMed

Spindle cell hemangioma, a rare benign tumor characterized by cavernous blood vessels and spindled areas, typically arises in the subcutis of the distal extremities, particularly the hand. The case of intraosseous spindle cell hemangioma is extremely rare, and only 1 case arises in the frontal bone has been reported previously. We describe herein a case of intraosseous spindle cell hemangioma occurring in the left calcaneus in a 65-year-old woman. The patient was successfully treated by the operation. The present case is instructive especially in the differential diagnosis of primary bone tumor structured by spindle cells, for which the possibility of spindle cell hemangioma should be considered. PMID:22534243

Hakozaki, Michiyuki; Tajino, Takahiro; Watanabe, Kazuo; Yamada, Hitoshi; Kikuchi, Shinichi; Hojo, Hiroshi; Ishida, Tsuyoshi; Konno, Shinichi

2012-10-01

216

Endoscopic nonembolized resection of an extensive sinonasal cavernous hemangioma: A case report and literature review.  

PubMed

Sinonasal hemangiomas, although rare, must be considered in the evaluation of intranasal masses with profuse epistaxis. Although the availability of literature discussing cavernous hemangiomas in this location is limited, there have been no case reports of exclusively soft tissue sinonasal cavernous hemangiomas extending to the anterior skull base (ASB) that were resected purely endoscopically. Here, we describe the successful endoscopic resection of an extensive right sinonasal cavernous hemangioma extending to but not invading the ASB. Although highly vascular, in select cases, these tumors can be successfully resected endoscopically without embolization by experienced endoscopic sinus and skull base surgeons. PMID:24498525

Kovalerchik, Olga; Husain, Qasim; Mirani, Neena M; Liu, James K; Eloy, Jean Anderson

2013-01-01

217

Endoscopic nonembolized resection of an extensive sinonasal cavernous hemangioma: A case report and literature review  

PubMed Central

Sinonasal hemangiomas, although rare, must be considered in the evaluation of intranasal masses with profuse epistaxis. Although the availability of literature discussing cavernous hemangiomas in this location is limited, there have been no case reports of exclusively soft tissue sinonasal cavernous hemangiomas extending to the anterior skull base (ASB) that were resected purely endoscopically. Here, we describe the successful endoscopic resection of an extensive right sinonasal cavernous hemangioma extending to but not invading the ASB. Although highly vascular, in select cases, these tumors can be successfully resected endoscopically without embolization by experienced endoscopic sinus and skull base surgeons.

Kovalerchik, Olga; Husain, Qasim; Mirani, Neena M.; Liu, James K.

2013-01-01

218

Hobnail hemangioma: a immunohistochemical study and literature review.  

PubMed

Hobnail hemangioma is a rare vascular lesion with unusual morphology, including bland cells with hobnail appearance, a biphasic grow pattern with superficial dilated vessels and slit-like vessels in a deeper portion of the lesion and the infiltrative pattern of later growth, which may cause misdiagnosis. The differential diagnosis with hemangioendothelioma variants, low grade angiosarcomas and Kaposi sarcoma is of particular concern. The lack of recognition of this uncommon entity may result in excessive and unnecessary treatment. Immunohistochemistry stains play an important role in hobnail hemangioma differential diagnosis. Here, we present the results of our researches and also review of the literature as well as discussion about usage of immunohistochemistry in the diagnosis of HH. PMID:23161236

Hejnold, Maria; Dyduch, Grzegorz; Mojsa, Izabela; Oko?, Krzysztof

2012-11-01

219

Cavernous hemangioma of the tongue: A rare case report  

PubMed Central

Hemangiomas are developmental vascular abnormalities and more than 50% of these lesions occur in the head and neck region, with the lips, tongue, buccal mucosa, and palate most commonly involved. They are considered as hamartomas rather than true neoplasms. Here we report a case of hemangioma of the body of the tongue, discussing the diagnostic aspects and treatment modalities of such lesion and emphasizing the role of the color Doppler ultrasonography, especially in the diagnosis and treatment. Factors such as patient's age, size and site of lesion and the proximity of lesion to vital structure are paramount in the determination of the therapeutic approach and surgical excision. Even though radiotherapy, cryotherapy, laser therapy, medical treatment, injection of sclerosing substances and the selective embolization of the lingual artery seem to have some efficacy, the author conclude that surgery is the therapy of choice in the isolated vascular lesions of the body of the tongue.

Kamala, K. A.; Ashok, L.; Sujatha, G. P.

2014-01-01

220

Bilateral episcleral brachytherapy in simultaneous choroidal melanoma and circumscribed hemangioma  

PubMed Central

Purpose To describe the efficacy of episcleral brachytherapy in a choroidal melanoma and circumscribed hemangioma arising in both eyes of the same patient. Case report We present the case of a 47 year old man who presented decreased visual acuity a few months preceding initial consult. On fundoscopy, he presented a melanotic lesion in the right eye, and a red-orange choroidal mass in the macular area of the left eye. Material and methods B scan-ultrasound, fluorescein, and indocyanine green angiography, confirmed the diagnosis of choroidal melanoma in the right eye, and circumscribed choroidal hemangioma in the left eye. Episcleral brachytherapy with 125I was performed in both eyes consecutively. Results and Conclusions Bilateral episcleral brachytherapy successfully treated both tumors, preserving the eyes and useful visual function.

Saornil, Maria Antonia; Garcia-Alvarez, Ciro; Martin, Francisco Lopez-Lara; Frutos-Baraja, Jesus Maria

2013-01-01

221

Angiomatous kaposi sarcoma: a variant that mimics hemangiomas.  

PubMed

We describe 14 cases of angiomatous Kaposi sarcoma (KS), a distinct histological variant of KS first mentioned by Gottlieb and Ackerman in 1988 that can easily be mistaken for a hemangioma. Intriguingly, this variant of KS has not attracted much attention and has not been studied in detail. Immunohistochemistry showed prominent staining of podoplanin (D2-40) of the neoplastic vasculature but not the preexisting vessels, suggesting lymphatic differentiation, despite the erythrocyte-filled round lumens. To test whether D2-40 staining of round vessels with erythrocytes was distinctive, we stained sinusoidal hemangiomas and cellular angiolipomas, both of which have these structures. In contrast to angiomatous KS, the vessels in both entities were podoplanin (D2-40) negative. The finding of round erythrocyte-filled vessels with podoplanin (D2-40) positivity may be distinctive for this form of KS. PMID:24067801

Yang, Sara H; LeBoit, Philip E

2014-03-01

222

Cavernous hemangioma of the tongue: A rare case report.  

PubMed

Hemangiomas are developmental vascular abnormalities and more than 50% of these lesions occur in the head and neck region, with the lips, tongue, buccal mucosa, and palate most commonly involved. They are considered as hamartomas rather than true neoplasms. Here we report a case of hemangioma of the body of the tongue, discussing the diagnostic aspects and treatment modalities of such lesion and emphasizing the role of the color Doppler ultrasonography, especially in the diagnosis and treatment. Factors such as patient's age, size and site of lesion and the proximity of lesion to vital structure are paramount in the determination of the therapeutic approach and surgical excision. Even though radiotherapy, cryotherapy, laser therapy, medical treatment, injection of sclerosing substances and the selective embolization of the lingual artery seem to have some efficacy, the author conclude that surgery is the therapy of choice in the isolated vascular lesions of the body of the tongue. PMID:24808705

Kamala, K A; Ashok, L; Sujatha, G P

2014-01-01

223

Pediatric lobular capillary hemangioma of the nasal cavity.  

PubMed

Lobular capillary hemangioma (LCH), also called pyogenic granuloma, is a benign vascular tumor that is pedunculated on the skin and the mucous membranes of the oral cavity. This disease occurs in all ages, but more often in the 3rd decade, and is seen in females more than males. LCH commonly appears in early childhood and affects males more than females in the pediatric age group. The gingiva, lips, tongue and buccal mucosa are the most common sites of mucosal LCH, but the nasal cavity is rare. Micro-trauma and hormonal factors are the most common etiologic factors. Epistaxis and nasal obstruction are the most marked symptoms. We describe the case of a 6-year-old girl with intra-nasal lobular capillary hemangioma presented with epistaxis and nasal obstruction. This should be considered in the differential diagnosis of childhood endonasal masses with bleeding. Total excision using endoscopic technique is the treatment of choice. PMID:14652770

Ozcan, Cengiz; Apa, Duygu Dü?mez; Görür, Kemal

2004-09-01

224

Cavernous hemangioma of the frontal bone: a case report  

PubMed Central

Introduction Cavernous hemangiomas are rare benign bone tumors and those at the level of the cranial bones are even rarer. Case presentation A 50-year-old woman of Italian ethnicity presented with a frontal mass. A computed tomography scan showed an osteolytic lesion and a magnetic resonance imaging scan revealed a hypointense lesion on the T1-weighted image and a hyperintense lesion on the T2-weighted image. We performed a tailored craniectomy and cranioplasty. Histological examination revealed a cavernous hemangioma. Conclusions These benign tumors do not have classic radiographic features and so can be misinterpreted as lesions like multiple myeloma or osteosarcoma. Consequently, the diagnosis is most often made during surgical resection.

2014-01-01

225

Blood-pool scintigraphic diagnosis of fractured lumbar vertebral hemangioma.  

PubMed

A 57-year-old woman complained of lumbago of 1 year's duration. Radiographs showed a compression fracture of the third lumbar vertebra. CT and MR images revealed an enhancing mass confined to the vertebral body suggestive of a malignant process. A blood-pool scintigram with 99mTc-human serum albumin combined with DTPA (HSA-D) revealed marked accumulation. This strongly suggested a hemangioma, which was confirmed by biopsy. PMID:11392297

Fujimoto, H; Ueda, T; Masuda, S; Nosaka, K

2001-04-01

226

Epithelioid Hemangioma (Angiolymphoid Hyperplasia with Eosinophilia) in Zosteriform Distribution  

PubMed Central

Epithelioid hemangioma (EH) or angiolymphoid hyperplasia with eosinophilia (ALHE) is an uncommon benign disease. We report an unusual case of EH (ALHE) that arose on the lower back in a zosteriform array. The presence of the characteristic histological appearance of plump endothelial cells with hobnail-like protrusions led to the diagnosis of EH (ALHE). Histological examination of the lesion also revealed the existence of arteriovenous shunts, the possible factor contributing to the pathogenesis of EH (ALHE).

Kurihara, Yuichi; Inoue, Hiroyoshi; Kiryu, Hiromaro; Furue, Masutaka

2012-01-01

227

Cavernous hemangioma-like kaposi sarcoma: a unique histopathologic variant.  

PubMed

: Kaposi sarcoma (KS) is an angiolymphatic neoplasm with multifactorial etiology. Clinically, KS has been divided into 4 distinct types and 3 well-defined histologic stages. Rare reports in the literature have characterized additional unique histopathologic variants. The authors report a case of KS, confirmed with human herpesvirus type 8 and D2-40 staining, which resembled a cavernous hemangioma on histopathology. PMID:24803066

Sutton, Angela M; Tarbox, Michelle; Burkemper, Nicole M

2014-05-01

228

Orbital venous-lymphatic malformations (lymphangiomas) mimicking cavernous hemangiomas  

Microsoft Academic Search

PURPOSE: To illustrate that orbital venous-lymphatic malformations (lymphangiomas) may rarely simulate cavernous hemangiomas.METHODS: Retrospective case review.RESULTS: Five patients were identified from a series of 85 patients with venous-lymphatic malformations. The age range was 21 to 69 years, and all cases presented with a history of slowly progressive or long-standing proptosis. Computerized tomography revealed relatively homogeneous intraconal masses that were well

Dinesh Selva; Diego Strianese; Giulio Bonavolonta; Jack Rootman

2001-01-01

229

Primary Intraosseous Hemangioma of the Orbit: CT and MR Appearance  

Microsoft Academic Search

Summary: An 8-year-old girl had acute onset of blurred vision, proptosis, and lateral and vertical gaze palsies on the right. CT and MR examinations showed an expansile mass involving the greater wing of the right sphenoid bone. Pathologic analysis of the surgical specimen revealed a capillary hemangioma. The lesion was inhomogeneous but predominantly isointense with gray matter on T1-weighted images.

Christopher Sweet; Richard Silbergleit; Bharat Mehta

230

Outcome of dorsolumbar vertebral hemangiomas presenting with neuraxial compression  

PubMed Central

Background: Hemangiomas are benign vascular tumors associated with proliferation of blood vessels in bone or soft tissue and they are usually incidental findings in vertebrae. When symptomatic, they present with features of radiculopathy, myelopathy, or vertebral fractures. Treatment options are varied, include sole embolization, embolization combined with surgical excision, surgical excision alone, percutaneous ablation, and radiotherapy. We hereby describe a series of seven cases of symptomatic vertebral hemangiomas operated from 2006 to 2009. Materials and Methods: Their clinical and radiological profile and outcome have been described. All patients were subjected to surgical excision followed by instrumentation. Outcome was assessed at a followup of 2 years following surgery with Frankel grading system. Results: Seven patients (five females and two males) were included in the study. The mean age was 33.85 years with the mean duration of symptoms of 12 months. All seven cases were symptomatic vertebral hemangiomas with cord compression and underwent surgical excision. Preoperatively, patients with poor Frankel grade such as A and B improved postoperatively to C, D, or E. Conclusion: Surgical excision of these lesions is difficult due to the tremendous amount of intraoperative bleeding. During surgery, brisk bleeding is usually encountered, but can be brought under control with adequate preoperative preparation and expertize. Preoperative embolization may help to reduce the bleeding, but at times it may be difficult to do if vertebrae are replaced by a solid hard mass. In spite of the risks associated with surgery, it still is the treatment of choice as a single intervention, especially in aggressive vertebral hemangiomas.

Nair, Anup P; Kumar, Raj; Srivastav, Arun Kumar; Sahu, Rabi Narayan; Kumar, Brijesh

2012-01-01

231

Hepatitis B and Hepatitis C in Pregnancy  

MedlinePLUS

What are hepatitis B and hepatitis C infections? Hepatitis B and hepatitis C are serious infections that affect the liver. Both diseases ... term illness. What extra risks are caused by hepatitis B and hepatitis C infections during pregnancy? Not only ...

232

Orbital cavernous hemangioma presenting with atypical appearance: case report.  

PubMed

A 25-year-old male presented with unilateral retroorbital dysesthesia persisting for 2 weeks followed by progressive palpebral ptosis without preceding trauma, paranasal sinus surgery, or infectious signs. Neuroophthalmological inspection revealed mildly increased intraocular pressure and exophthalmos on the affected side, without conjunctival chemosis, restriction of the extraocular movements, double vision, or visual impairment. These symptoms did not vary with posture, straining, and Valsalva maneuver. Neuroimaging showed an irregularly-shaped orbital mass without enhancement mainly situated in the medial compartment of the orbit and encasing the optic nerve. Bruit was not audible and abnormal vasculatures were not identified in and around the affected orbit. Transcranial surgical exploration through the surgical window formed by the superior and medial rectus muscles revealed a purplish elastic-soft mass, heterogeneous in consistency and tightly adhering to the surrounding tissue, so cryoprobe-assisted radical tumor resection could not be completed without jeopardizing the optic nerve. The mass was subtotally resected piecemeal without postoperative visual impairment. The histological diagnosis was cavernous hemangioma. Orbital cavernous hemangiomas may present with an atypical appearance which confuses pretreatment diagnosis and makes surgical extirpation more hazardous. Conservative surgery should be indicated for poorly demarcated orbital cavernous hemangiomas considering the usual benign clinical course and postoperative sequelae. PMID:19465792

Akiyama, Osamu; Tsutsumi, Satoshi; Suga, Yasuo; Abe, Yusuke; Yasumoto, Yukimasa; Ito, Masanori

2009-05-01

233

Involution of endophytic optic disc hemangioma with a single session of photodynamic treatment.  

PubMed

We report a 58-year-old otherwise healthy woman with unilateral endophytic optic disc hemangioma and associated serous retinal detachment and exudation. A standard verteporfin dose was given and a photodynamic treatment (PDT) protocol was followed. A moderate vitreous hemorrhage occurred four days after PDT. The hemangioma regressed markedly 6 weeks after the procedure and serous retinal detachment showed marked resolution. PMID:17914208

Yaman, Aylin; Saatci, Ali Osman; Arikan, Gul; Gunduz, Kaan

2007-01-01

234

Postcricoid Hemangioma: An Overlooked Cause of Dysphagia in Infants?–A Case Report  

Microsoft Academic Search

Feeding and swallowing disorders in children remain a major challenge owing to a wide differential diagnosis. Hemangioma of the upper aerodigestive tract represents one of the numerous non-neoplastic causes of dysphagia. We report two cases of postcricoid hemangioma causing inhalation and recurrent respiratory infections, treated successfully with systemic corticotherapy alone. To our knowledge, these are the second and third cases

Gauthier R. R. Desuter; Kamal El Makhloufi; Geneviève J. François; Veronique M. Godding; Christine Saint-Martin; Jean-Paul Buts; M. F. A. Hamoir

2004-01-01

235

Intravenous lobular capillary hemangioma occurring in the cephalic vein of a 39-year-old adult.  

PubMed

Intravenous lobular capillary hemangiomas are extremely uncommon and mostly occur in the veins of the neck and upper extremities. Here, we report the clinical and sonographic features of an intravenous lobular capillary hemangioma localized in the right cephalic vein, and we discuss its pathologic findings and differential diagnoses. © 2013 Wiley Periodicals, Inc. J Clin Ultrasound 42:375-378, 2014. PMID:24151094

Ahn, Sung Eun; Park, Ji Seon; Ryu, Kyung Nam; Jin, Wook; Park, So Young

2014-07-01

236

Hobnail hemangioma in a nine-year-old boy: a rare case presented with dermoscopy.  

PubMed

Hobnail hemangioma is a benign vascular tumor that typically occurs on the trunk and extremities. Most patients present in the 20s and 30s. We describe a rare case of hobnail hemangioma in a 9-year-old male. PMID:20409414

Ibrahim, Marian; Shwayder, Tor

2010-01-01

237

Minimal invasive method to treat hemangiomas of the oral cavity with a CO2 laser  

Microsoft Academic Search

During the last six years we have developed a new CO2 laser technique for the treatment of symptomatic oral cavity hemangioma. Our new technique, named 'laser encircling technique', has especially succeeded during hemangioma buccal maxillary surgeries. The treatment consisted in the application of a line of points of CO2 laser circling the lesion. Depending on the position and size of

Ester M. Nicola; Jorge H. Nicola; Reinaldo J. Gusmao; Adriana A. Coutinho; Nilceu Cassitas

1997-01-01

238

Cervicothoracic spinal epidural cavernous hemangioma: case report and review of the literature  

Microsoft Academic Search

Cavernous hemangiomas are vascular malformations that effect the central nervous system. This pathology is frequently encountered in the cerebral hemispheres, cerebellum, and brainstem. Cavernous hemangiomas, although usually solitary, may be associated with the same lesion in other parts of the central nervous system or other organ systems and may appear as sporadic or familial cases. They are infrequently found at

Nguyen Huu Minh

2005-01-01

239

Cavernous Hemangioma of the Scrotum: A Rare Benign Genital Tumor of Childhood  

Microsoft Academic Search

Cavernous hemangioma is a benign congenital lesion that rarely involves the scrotum and primarily presents during childhood. We report a case of subcutaneous scrotal-perineal hemangioma in a boy initially believed to have an inguinal hernia. These lesions can be diagnostically and therapeutically challenging. Definitive treatment by en bloc excision is recommended. Special staining techniques may be required for accurate pathological

Fernando A. Ferrer; Patrick H. McKenna

1995-01-01

240

Surgical treatment of a cavernous hemangioma of the left atrial roof  

Microsoft Academic Search

A hemangioma that occurs as a primary tumor of the heart is extremely rare. The authors experienced a cavernous hemangioma located in the epicardium of the left atrial roof in a patient who had paroxysmal atrial fibrillation. Resection of the tumor and cryo-coagulation yielded a satisfactory clinical course. No recurrence of the tumor is noted at the time of 5

Y. Matsumoto; G. Watanabe; M. Endo; H. Sasaki

2001-01-01

241

Transcatheter arterial embolization in the treatment of symptomatic cavernous hemangiomas of the liver: a prospective study  

Microsoft Academic Search

Background: This prospective study evaluated the clinical and radiologic results of transcatheter arterial embolization (TAE) for the treatment of symptomatic cavernous hemangiomas of the liver. The technique, its complications, and effectiveness also were analyzed. Methods: Eight patients (five male, three female; mean age - SD = 47.75 - 8.59 years) with symptomatic cavernous hemangiomas of the liver were treated by

D. N. Srivastava; D. Gandhi; A. Seith; G. K. Pande; P. Sahni

2001-01-01

242

Preoperative Percutaneous Injection of Methyl Methacrylate and N-Butyl Cyanoacrylate in Vertebral Hemangiomas  

Microsoft Academic Search

PURPOSE: To investigate the usefulness of preoperative percutaneous injections in vertebral hemangiomas. METHODS: Four patients presented with complicated vertebral hemangioma (spi- nal cord compression in three cases, intermittent spinal claudiction in one case). A three-part treatment was performed: initially, arterial embolization in three cases; 1 day later, percutaneous injections of methyl methacrylate into the vertebral body to strengthen it and

Anne Cotten; Bernard Cortet; Jean-Paul Lejeune; Xavier Leclerc; Patrick Chastanet; Jacques Clarisse

243

Infantile hemangiomas are arrested in an early developmental vascular differentiation state  

Microsoft Academic Search

Infantile hemangiomas, the most common tumors of infancy, are vascular tumors characterized by rapid proliferation of endothelial cells during the first few months of postnatal life followed by slow spontaneous involution, whose molecular pathogenesis remains unclear. The recent identification of developmental expression of vascular lineage-specific markers prompted us to characterize infantile hemangiomas for the expression of lymphatic endothelial hyaluronan receptor-1

Soheil S Dadras; Paula E North; Jennifer Bertoncini; Martin C Mihm; Michael Detmar

2004-01-01

244

Infantile hemangioma is a proliferation of LYVE-1-negative blood endothelial cells without lymphatic competence  

Microsoft Academic Search

Infantile hemangiomas are common benign vascular tumors that exhibit a characteristic history of rapid proliferation in the first year of life and slow spontaneous involution during early childhood. The causative pathogenic event responsible for the abnormal endothelial proliferation remains elusive. The recent discovery of an immature phenotype of proliferating hemangioma endothelial cells due to the exclusive expression of the lymphatic

Van An Nguyen; Heinz Kutzner; Christina Fürhapter; Alexandar Tzankov; Norbert Sepp

2006-01-01

245

Hepatitis virus panel  

MedlinePLUS

Hepatitis A antibody test; Hepatitis B antibody test; Hepatitis C antibody test; Hepatitis D antibody test ... or past infection, or immunity to hepatitis A Hepatitis B tests: Hepatitis B surface antigen (HBsAg) -- you have ...

246

Noncontiguous lumbar vertebral hemangiomas treated by posterior decompression, intraoperative kyphoplasty, and segmental fixation.  

PubMed

Vertebral hemangiomas are benign lesions and are often asymptomatic. Most vertebral hemangiomas that cause cord compression and neurological symptoms are located in the thoracic spine and involve a single vertebra. The authors report the rare case of lumbar hemangiomas in a 60-year-old woman presenting with severe back pain and rapidly progressive neurological signs attributable to 2 noncontiguous lesions. After embolization of the feeding arteries, no improvement was noted. Thus, the authors performed open surgery using a combination of posterior decompression, intraoperative kyphoplasty, and segmental fixation. The patient experienced relief from back and leg pain immediately after surgery. At 3 months postoperatively, her symptoms and neurological deficits had improved completely. To the authors' knowledge, this is the first description of 2 noncontiguous extensive lumbar hemangiomas presenting with neurological symptoms managed by such combined treatment. The combined management seems to be an effective method for treating symptomatic vertebral hemangiomas. PMID:24236666

Yu, Bin; Wu, Desheng; Shen, Bin; Zhao, Weidong; Huang, Yufeng; Zhu, Jianguang; Qi, Dongduo

2014-01-01

247

External and intralesional photocoagulation of hemangioma in children with infrared diode laser  

NASA Astrophysics Data System (ADS)

Infra-red diode laser with wavelength 1060 nm was used for combined treatment of 163 children aged from 21 days to 13 years with 221 hemangiomas. For interstitial coagulation a power of 1.8-2 W and a power density of 5-90 J/cm3 were used in continuous mode. For distant coagulation pulse mode was applied with pulse/pause duration 30-50/200-250 ms, average power 1.3-2 W, and power density 65-450 J/cm2. 197 (89.1 %) hemangiomas were capillary, 7 (3.2 %) cavernous, and 17 (7.7 %) combined (combination of capillary and cavernous hemangiomas). The area of hemangiomas ranged from 6 mm2 to 48 cm2. For the majority (193, 87.3 %) of hemangiomas one session of photocoagulation was enough to achieve a good cosmetic effect. However, 28 (12.7 %) hemangiomas were treated repeatedly, 11 (5%) of them needed 4-7 sessions. In 8 children with cavernous and combined hemangiomas both distant and interstitial laser coagulation were used. In all, good or excellent results were obtained in 96,3 % of the patients. In 6 (3.7%) patients with extensive combined hematomas the considerable improvement was achieved.

Abushkin, Ivan A.; Privalov, Valery A.; Lappa, Alexander V.; Besshtanko, Evgeny L.

2005-08-01

248

Large capillary hemangioma of the temporal bone with a dural tail sign: A case report  

PubMed Central

The present study reports a rare case of large capillary hemangioma of the temporal bone with a dural tail sign. A 57-year-old female presented with pulsatile tinnitus and episodic vertigo associated with a ten-year history of an intermittent faint headache. Magnetic resonance imaging revealed a mass in the right petrous bone, which was hypointense on T1-weighted images and heterogeneously hyperintense on T2-weighted images, and showed a dural tail sign following gadolinium administration. Pre-operatively, this tumor was believed to be a meningioma. During surgery, the vascular tumor was removed by a modified pterional approach. A histopathological examination indicated that the tumor was a capillary hemangioma. Although intraosseous capillary hemangiomas are rare, they most frequently affect the temporal bone. Hemangiomas of the temporal bone may mimic other more common basal tumors. The diagnosis is most often made during surgical resection. The dural tail sign is not specific for meningioma, as it also occurs in other intracranial or extracranial tumors. The treatment of intratemporal hemangiomas is complete surgical excision, with radiotherapy used for unresectable lesions. To the best of our knowledge, the present study is the fourth case of intraosseous intracranial capillary hemangioma, but the largest intratemporal hemangioma to be reported in the literature to date.

YANG, GUANG; LI, CHENGUANG; CHEN, XIN; LIU, YAOHUA; HAN, DAYONG; GAO, XIN; KAWAMOTO, KEIJI; ZHAO, SHIGUANG

2014-01-01

249

[Imaging features of cavernous hemangiomas of the orbit].  

PubMed

Cavernous hemangioma is the most frequent benign tumor of the orbit. The clinical presentation is that of a slowly progressive intra-orbital mass with variable degree of exophthalmos. CT typically demonstrates the presence of a well defined oval or rounded shaped mass but MRI provides superior evaluation of the orbit. The tumor is intra-conal in 80% of cases and usually shows T1W hypo-isointensity, T2W hyperintensity and heterogeneous contrast enhancement that becomes more homogeneous on delayed imaging (5 minutes). PMID:19752807

Dallaudiere, B; Benayoun, Y; Boncoeur-Martel, Mp; Robert, Py; Adenis, Jp; Maubon, A

2009-09-01

250

Idiopathic giant retinal cyst.  

PubMed

The authors describe a case report of idiopathic asymptomatic giant retinal cyst with underlying hyperpigmentation. Low- and high-frequency ultrasound (ultrasound biomicroscopy) revealed an anechoic giant cyst with two hyper-reflective traction bands between the ciliary body and the anterior base of the retinal cyst. There was no retinal detachment. PMID:24840531

Chen, Carlos Y; Semenova, Ekaterina; Cohen, Ben Z; Finger, Paul T

2014-01-01

251

Peripheral giant cell granuloma  

PubMed Central

Peripheral giant cell granuloma or the so-called “giant cell epulis” is the most common oral giant cell lesion. It normally presents as a soft tissue purplish-red nodule consisting of multinucleated giant cells in a background of mononuclear stromal cells and extravasated red blood cells. This lesion probably does not represent a true neoplasm, but rather may be reactive in nature, believed to be stimulated by local irritation or trauma, but the cause is not certainly known. This article reports a case of peripheral giant cell granuloma arising at the maxillary anterior region in a 22-year-old female patient. The lesion was completely excised to the periosteum level and there is no residual or recurrent swelling or bony defect apparent in the area of biopsy after a follow-up period of 6 months.

Tandon, Padam Narayan; Gupta, S. K.; Gupta, Durga Shanker; Jurel, Sunit Kumar; Saraswat, Abhishek

2012-01-01

252

Massive splenomegaly caused by cavernous hemangiomas associated with Klippel-Trenaunay syndrome: report of a case.  

PubMed

The etiology of Klippel-Trenaunay syndrome (KTS) is not well understood. Although splenic involvement is very rare in KTS, life-threatening events such as spontaneous rupture of a splenic hemangioma may occur. We recently performed elective splenectomy for massive splenomegaly causing uncontrollable abdominal pain in a woman with KTS. The extracted spleen weighed 4260 g, and cavernous hemangiomas in the spleen were found to be the cause of the splenomegaly. The patient's abdominal pain resolved after surgery and her postoperative course was uneventful, except for persistent bleeding from the bladder. This is a rare case of KTS with associated severe splenomegaly caused by hemangiomas. PMID:24254059

Misawa, Takeyuki; Shiba, Hiroaki; Fujiwara, Yuki; Futagawa, Yasuro; Harada, Toru; Ikegami, Masahiro; Yanaga, Katsuhiko

2014-01-01

253

Successful detection and surgical treatment of cardiac hemangioma with right ventricular invasion.  

PubMed

Cardiac hemangiomas are extremely rare benign tumors. These tumors are usually asymptomatic but they can present symptoms such as palpitations, shortness of breath, and arrythmia. We report the case of a 73-year-old man who presented with an abnormal shadow on chest computed tomography during follow-up for lung metastatic tumor after resection of his rectal cancer. A cardiac tumor was detected, and surgical resection and right ventricular plasty were successfully performed with the patient under cardiopulmonary bypass. Histopathologic examination revealed a benign cardiac hemangioma, which was categorized as a hemangioma of the mixed cavernous and capillary type. PMID:24088470

Iida, Yasunori; Ito, Tsutomu; Kitahara, Hiroto; Takebe, Motojiro; Nemoto, Atsushi; Shimokawa, Reiko; Yoshitake, Akihiro; Misumi, Takahiko

2013-10-01

254

Unusual Features in an Adult Pancreatic Hemangioma: CT and MRI Demonstration  

PubMed Central

Hemangiomas in the pancreas are very rare and only a few cases in adulthood have been reported in the literature. We describe a case of pancreatic hemangiomas in an adult with unique imaging findings. A 23-year-old woman visited the hospital for an incidentally detected pancreatic mass. CT and MRI revealed a multilocular cyst with fluid-fluid levels and no obvious enhancement. The patient underwent surgery and the mass was confirmed as a pancreatic hemangioma. The radiological features and differential diagnosis of this rare lesion are discussed.

Wu, Mei

2013-01-01

255

Complementary role of SPECT in the diagnosis of cavernous hemangioma of the liver  

SciTech Connect

Cavernous hemangiomas are the most common benign tumors of the liver. Although their clinical course is usually uncomplicated, an accurate diagnosis may be important to exclude conditions that need treatment, (or to avoid an unnecessarily risky percutaneous biopsy). Although blood pool scintigraphy using planar gamma camera imaging is a reliable examination for the diagnosis of liver hemangiomas, it may fail to depict small, deeply seated lesions, and hence miss the diagnosis. Two cases are reported in which SPECT demonstrated delayed pooling in small, deep, space-occupying lesions, which were poorly seen on planar images, and therefore made a cavernous hemangioma the most likely diagnosis.

Tumeh, S.S.; English, R.J.; Holman, B.L.

1985-12-01

256

Viral Hepatitis  

MedlinePLUS

... information Breastfeeding HIV/AIDS Illnesses and disabilities Pregnancy Sexually transmitted infections fact sheet What is hepatitis? What are the ... Hepatitis B prevention Get vaccinated. As with other sexually transmitted infections, limit sexual partners and use latex condoms to ...

257

Hepatic Cysts.  

PubMed

Treatment of hepatic cysts should be considered only for those patients who are symptomatic. For simple cysts, percutaneous aspiration invariably leads to recurrence; laparoscopic deroofing is usually curative. Open deroofing (fenestration) should be reserved for cysts inaccessible by laparoscopy. Percutaneous instillation of sclerosing agents (ethanol, iophendylate, minocycline) into nonbiliary and nonparasitic cysts is an alternative therapeutic option in certain cases. Due to increased morbidity, hepatic resection should be reserved for polycystic liver disease, diffuse hepatic involvement, or recurrence after a deroofing procedure. Patients with congenital fibropolycystic disorders (eg, congenital hepatic fibrosis) with evidence of hepatic decompensation, should be considered for liver transplantation. For hepatic hydatid cysts, simple cystectomy or the PAIR (puncture, aspirate, inject, and reaspirate) technique with albendazole treatment have been shown to be equally successful. In the case of alveolar echinococcosis, hepatic resection and liver transplantation are the only effective modalities for localized and extensive hepatic disease, respectively. PMID:11096603

Kaul; Friedenberg; Rothstein

2000-12-01

258

Hepatitis A  

MedlinePLUS

... Working in a health care, food, or sewage industry Other common hepatitis virus infections include hepatitis B ... steps to protect against getting the disease: Avoid dairy products. Avoid raw or undercooked meat and fish. ...

259

Hepatitis A FAQs  

MedlinePLUS

... C. What is the difference between Hepatitis A, Hepatitis B, and Hepatitis C? Hepatitis A , Hepatitis B , and Hepatitis C are diseases caused by three ... People with Hepatitis A usually improve without treatment. Hepatitis B and Hepatitis C can also begin as acute ...

260

Hepatitis C FAQs  

MedlinePLUS

... C. What is the difference between Hepatitis A, Hepatitis B, and Hepatitis C? Hepatitis A , Hepatitis B , and Hepatitis C are diseases caused by three ... People with Hepatitis A usually improve without treatment. Hepatitis B and Hepatitis C can also begin as acute ...

261

Subretinal Hemorrhage after Photodynamic Therapy for Juxtapapillary Retinal Capillary Hemangioma  

PubMed Central

A 75-year-old Japanese woman presented with a juxtapapillary retinal capillary hemangioma (RCH) in her left eye. Twelve months after the initial examination, the size of the hemangioma had increased and the exudation from the RCH involved the macula. Her best-corrected visual acuity (BCVA) had decreased from 0.8 to 0.3. A total of five intravitreal injections of bevacizumab (IVB; 1.25 mg) was given but the RCH did not respond. A photodynamic therapy (PDT) was done using multiple laser spots to avoid damaging the optic nerve head. After the first PDT, the subfoveal fluid was reduced but not completely gone. One week after the second PDT, a massive subretinal hemorrhage developed. The subretinal hemorrhage was successfully displaced by injecting intraocular sulfur hexafluoride (SF6) gas. At the 3-year follow-up examination, no subretinal hemorrhage or fluid was observed at the macula and the BCVA remained at 0.05. Our case was resistant to the combination of anti-vascular endothelial growth factor (VEGF) and PDT and had a rare massive subretinal hemorrhage. A further collection of RCH cases treated with anti-VEGF and PDT that would justify this treatment is necessary.

Baba, Takayuki; Kitahashi, Masayasu; Kubota-Taniai, Mariko; Oshitari, Toshiyuki; Yamamoto, Shuichi

2011-01-01

262

Diode laser photocoagulation in PHACES syndrome hemangiomas: a case series  

NASA Astrophysics Data System (ADS)

PHACES syndrome is a pediatric syndrome with cutaneous and extra-cutaneous manifestations, such as Posterior fossa defects, Hemangiomas, Arterial lesions, Cardiac abnormalities/aortic coarctation, Eye abnormalities and Sternal cleft. Facial hemangiomas affect the 75% of patients and may arise on the oral mucosa or perioral cutaneous regions. In this study we treated 26 Intraoral Haemangiomas (IH) and 15 Perioral Haemangiomas (PH) with diode laser photocoagulation using a laser of 800+/-10nm of wavelength. For IH treatment an optical fiber of 320 ?m was used, and the laser power was set ted at 4 W (t-on 200 ms / t-off 400ms; fluence: 995 J/cm2). For PH treatment an optical fiber of 400 ?m at the power of 5 W was used (t-on 100 ms / t-off 300 ms; fluence: 398 J/cm2). IH healed after one session (31%), the other (69%) after two sessions of Laser therapy. In each session, only a limited area of the PH was treated, obtaining a progressive improvement of the lesion. Diode laser photocoagulation is an effective option of treatment for IH and PH in patients affected by PHACE because of its minimal invasiveness. Moreover laser photocoagulation doesn't have side effects and can be performed repeatedly without cumulative toxicity. Nevertheless, more studies are required to evaluate the effectiveness of the therapy in mid and long time period.

Romeo, U.; Russo, N.; Polimeni, A.; Favia, G.; Lacaita, M. G.; Limongelli, L.; Franco, S.

2014-01-01

263

Mortality in a cohort of radiation treated childhood skin hemangiomas.  

PubMed

Mortality was studied in 18,357 patients (33% males and 67% females) with skin hemangioma admitted to Radiumhemmet between 1920 and 1959. The treatments of the hemangiomas were performed by radium-226 sources (13,094 patients) or x-ray therapy (2,540 patients). In 2,723 patients no radiotherapy was given. The median age was 6 months for the treated patients and 8 months for the patients not receiving radiotherapy. Between 1920 and 1951 a total of 154 patients were reported dead. The cohort was matched with the Swedish Cause of Death Register between 1952 and 1985. During that period 504 died, in 146 patients the cause of death was cancer or leukemia. The total number of person-years at risk was 587,426. In patients treated with radium-226 or orthovoltage x-rays, 410 deaths occurred (standardized mortality ratio (SMR) = 1.07; ns). In patients given contact therapy 34 deaths occurred (SMR = 0.82; ns) and in the not irradiated group 60 deaths occurred (SMR = 0.78; ns). Patients treated with radium-226 or orthovoltage x-rays had an SMR of 1.34 for all cancers combined (p less than 0.05). For patients treated between 1920 and 1939 the SMR for cancer was 1.53 (p less than 0.05) as compared to an SMR of 1.16 (ns) for those treated between 1940 and 1959. PMID:2611031

Fürst, C J; Silfverswärd, C; Holm, L E

1989-01-01

264

Lumbar vertebral hemangioma mimicking lateral spinal canal stenosis: case report and review of literature.  

PubMed

Context Hemangiomas are the commonest benign tumors of the spine. Most occur in the thoracolumbar spine and the majority are asymptomatic. Rarely, hemangiomas cause symptoms through epidural expansion of the involved vertebra, resulting in spinal canal stenosis, spontaneous epidural hemorrhage, and pathological burst fracture. Findings We report a rare case of a 73-year-old woman, who had been treated for two months for degenerative neurogenic claudication. On admission, magnetic resonance imaging and computed tomographic scans revealed a hemangioma of the third lumbar vertebra protruding to the epidural space producing lateral spinal stenosis and ipsilateral nerve root compression. The patient underwent successful right hemilaminectomy for decompression of the nerve root, balloon kyphoplasty with poly-methyl methacrylate (PMMA) and pedicle screw segmental stabilization. Postoperative course was uneventful. Conclusion In the elderly, this rare presentation of spinal stenosis due to hemangiomas may be encountered. Decompression and vertebral augmentation by means balloon kyphoplasty with PMMA plus segmental pedicle screw fixation is recommended. PMID:24090267

Syrimpeis, Vasileios; Vitsas, Vasileios; Korovessis, Panagiotis

2014-03-01

265

[An intraosseous hemangioma in the perpendicular lamina of the ethmoid bone].  

PubMed

The incidence of intraosseous hemangiomas is very low. Most of them occur in adult females. The mandible,the zygoma,the maxilla, and the frontal and nasal bones are the areas of most frequent localization in the facial region. The intraosseous hemangioma is a benign, slowly growing,bony hard tumor causing facial deformity. It is diagnosed histologically. We report a case of an 18-year-old male with an intraosseous cavernous hemangioma located in the perpendicular lamina of the ethmoid bone. Intraosseous hemangioma often has characteristic signs on a CT scan, with either coarsened trabeculae lying adjacent to the vascular channels or multifocal lytic areas creating a honeycomb pattern. Because of the age of the patient we considered a midline granuloma and a chondrosarcoma. The therapy of choice is surgical excision; radiation is done in exceptional cases only. PMID:12589420

Graumüller, S; Terpe, H; Hingst, V; Dommerich, S; Pau, H W

2003-02-01

266

A hemangioma of the sigmoid colon mesentery presenting as a retroperitonealtumor: a case report and review  

PubMed Central

Hemangiomas of the gastrointestinal tract and mesentery are uncommon benign vascular lesions. While spontaneous bleeding is the hallmark of the gastrointestinal tumor variant, clinical signs of mesenteric hemangiomas are mostly unspecific. Despite the increasing imaging quality of computerized tomography (CT), in most cases the final diagnosis is established through surgery and histopathologic analysis of a macrobiopsy. We present a case report of a 20-year-old female patient who was admitted with progressive abdominal distension and suffered from persistent abdominal pain for 3 months. A large retroperitoneal tumor mass was detected on the CT scan. Due to radiographic signs of an intraabdominal liposarcoma, an explorative laparotomy was performed revealing a large hemangioma originating from the mesosigmoid. Although rare, gastrointestinal hemangiomas should be kept in mind by oncological visceral surgeons as one differential diagnosis of large intraabdominal tumorous masses, especially in young adults.

2014-01-01

267

Mice with hemangiomas induced by transgenic endothelial cells. A model for the Kasabach-Merritt syndrome.  

PubMed Central

Inoculation of an established endothelial cell line from transgenic mouse hemangiomas (Py-4-1) into histocompatible mice induced vascular tumor formation at the site of infection with 100% frequency. Histological and hematological studies revealed that the mice developed hemangiomas with hematological changes similar to those found in the Kasabach-Merritt syndrome in humans, including hemolytic anemia and thrombocytopenic purpura. Modifications in the red blood cell count, hemoglobin concentration, hematocrit, and platelet count were directly correlated with the size of the hemangioma. Thus transgenic endothelial cell injection into histocompatible mice provides an in vivo model system to study the pathobiology of hemangiomas as well as the investigation of angiogenesis inhibitors. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 7 Figure 8

Dubois-Stringfellow, N.; Kolpack-Martindale, L.; Bautch, V. L.; Azizkhan, R. G.

1994-01-01

268

Topical Treatment for Orbital Capillary Hemangioma in an Adult Using a ?-Blocker Solution  

PubMed Central

Purpose To report a case of orbital capillary hemangioma in an adult who was successfully treated with topical timolol maleate 0.5% solution. Methods Case report. Results A 43-year-old female presented both superficial and deep orbital capillary hemangioma. Topical timolol maleate was applied twice daily. The superficial lesions have nearly disappeared after 1 year of treatment. The deeper lesions have also been reduced in size according to MRI. Conclusion We report an adult patient with a relatively large orbital capillary hemangioma who was successfully treated with a topical ?-blocker solution. This treatment might be applicable for orbital capillary hemangiomas, regardless of the patient's age, because of its effectiveness and safety.

Ohnishi, Ken; Tagami, Mizuki; Morii, Eiichi; Azumi, Atsushi

2014-01-01

269

Difficult treatment of consumptive hypothyroidism in a child with massive parotid hemangioma.  

PubMed

Consumptive hypothyroidism is a rare condition related to massive infantile hemangiomas producing an excess of the thyroid-hormone-inactivating enzyme type 3 iodothyronine deiodinase. We report the first case of consumptive hypothyroidism secondary to a large parotid hemangioma, highlighting the difficulties in selecting an adequate therapeutic strategy. The affected child was initially referred to our center for congenital hypothyroidism with a hypoplastic thyroid gland. L-Thyroxine (L-T4) replacement therapy was started at seven days of life. In the following weeks, the hemangioma rapidly increased in volume and the child developed severe hypothyroidism refractory to high doses of L-T4 therapy. The concentration of reverse triiodothyronine was elevated, suggesting that the underlying cause was an excessive conversion of thyroid hormones by high type 3 iodothyronine deiodinase levels in the tumor. Corticosteroid treatment showed only partial benefit. Introduction of propranolol instead led to normalization of thyroid hormones along with a dramatic involution of the hemangioma. PMID:22570966

Vigone, Maria Cristina; Cortinovis, Francesca; Rabbiosi, Sarah; Di Frenna, Marianna; Passoni, Arianna; Persani, Luca; Chiumello, Giuseppe; Gelmetti, Carlo; Weber, Giovanna

2012-01-01

270

Intraventricular cavernous hemangioma at the foramen of Monro: Case report and literature review  

Microsoft Academic Search

Cavernous hemangiomas rarely occur in the cerebral ventricles. Those occurring at the foramen of Monro are even less frequent. So far, only eight cases of cavernous hemangioma at the foramen of Monro have been reported in the literature. Here, we present a similar case and correlated the radiographic with the histopathologic findings of the patient.A 51-year-old woman was admitted with

Chun-Lin Chen; Ching-Hsiang Leu; Yee-Jee Jan; Chiung-Chyi Shen

2006-01-01

271

Massive exudative retinal detachment following photodynamic therapy for retinal hemangioma in von Hippel-Lindau Syndrome.  

PubMed

Photodynamic therapy (PDT) is a common treatment on retinal capillary hemangioma. We applied PDT to a patient with von Hippel-Lindau(VHL) syndrome and she developed severe massive exudative retinal detachment the next day, which is a rare complication for PDT. After intraocular anti-VEGF agent and peribulbar dexamethasone several times to the patient, her subretinal fluid disappeared and hemangiomas atrophied. Treatment with Anti-VEGF agent and corticosteroid is effective for such complication. PMID:24632330

Chen, Yao; Liu, Hong; Zhang, Kun; Gao, Ling

2014-06-01

272

A pedunculated left ventricular hemangioma initially misdiagnosed as thrombus in a woman with atypical chest pain  

Microsoft Academic Search

The incidence of cardiac masses increased as echocardiography is becoming increasingly popular. Benign tumors of the heart\\u000a constitute about 72% of all primary cardiac neoplasms and hemangioma accounts for 5–10% of benign cardiac tumors. Cardiac\\u000a hemangiomas are generally asymptomatic and diagnosed incidentally during echocardiography or magnetic resonance imaging (MRI).\\u000a We reported a 52-year-old woman presented with atypical chest pain and

M. Azra Tanrikulu; Beste Ozben; A. Altug Cincin; Ozdil Baskan; Mehmet Agirbasli

2009-01-01

273

Supratentorial Convexity Dural-Based Cavernous Hemangioma Mimicking a Meningioma in a Child  

Microsoft Academic Search

A case of a convexity dural-based cavernous hemangioma in a 15-year-old male child is reported. The child presented only with headaches and had no neurological deficits. MRI features were suggestive of a meningioma. The tumor was completely resected and histology was conclusive of a hemangioma. At follow-up after 2 years, the child is asymptomatic and MRI showed no evidence of

V. Joshi; D. Muzumdar; N. Dange; A. Goel

2009-01-01

274

Longstanding symptomatic choroidal hemangioma managed with limited PDT as initial or salvage therapy  

Microsoft Academic Search

Purpose To describe the use of limited, low-irradiance, single-spot photodynamic therapy (PDT) with verteporfin for the treatment of symptomatic choroidal hemangiomas. Methods Thirteen consecutive patients with a circumscribed choroidal hemangioma were treated with limited PDT 6 min following a 1-min infusion with verteporfin (6 mg\\/m 2 body surface area), using a diode laser (692 nm) and a single spot large enough to cover

F. D. Verbraak; R. O. Schlingemann; J. E. E. Keunen; M. D. de Smet

2003-01-01

275

Severe progressive scoliosis due to huge subcutaneous cavernous hemangioma: A case report  

Microsoft Academic Search

Cavernous hemangioma consists mainly of congenital vascular malformations present before birth and gradually increasing in\\u000a size with skeletal growth. A small number of patients with cavernous hemangioma develop scoliosis, and surgical treatment\\u000a for the scoliosis in such cases has not been reported to date. Here we report a 12-year-old male patient with severe progressive\\u000a scoliosis due to a huge subcutaneous

Yoji Ogura; Kota Watanabe; Naobumi Hosogane; Takashi Tsuji; Ken Ishii; Masaya Nakamura; Yoshiaki Toyama; Kazuhiro Chiba; Morio Matsumoto

2011-01-01

276

Are bilateral cavernous hemangiomas of the orbit rare entities? The role of MRI in a retrospective study  

Microsoft Academic Search

Cavernous hemangioma is a benign orbital extraocular vascular lesion consisting of large dilated venous channels with fibrous, well-delineated capsule and hemosiderin deposition. Cavernous hemangioma is considered to be almost always unilateral and bilateral cases have been rarely described.The aim of our study is to evaluate imaging characteristics of cavernous hemangioma and evaluate the prevalence of bilateral cases.We studied 14 patients

Amalia Paonessa; Nicola Limbucci; Massimo Gallucci

2008-01-01

277

The Next Giant Step  

NASA Video Gallery

Artist Robert McCall painted "The Next Giant Step" in 1979 to commemorate the heroism and courage of spaceflight pioneers. Located in the lobby of Johnson's building 2, the mural depicts America's ...

278

The Giant Cell.  

ERIC Educational Resources Information Center

Provides directions for the construction of giant plastic cells, including details for building and installing the organelles. Also contains instructions for preparing the ribosomes, nucleolus, nucleus, and mitochondria. (DDR)

Stockdale, Dennis

1998-01-01

279

Intrinsic regulation of hemangioma involution by platelet-derived growth factor.  

PubMed

Infantile hemangioma is a vascular tumor that exhibits a unique natural cycle of rapid growth followed by involution. Previously, we have shown that hemangiomas arise from CD133+ stem cells that differentiate into endothelial cells when implanted in immunodeficient mice. The same clonally expanded stem cells also produced adipocytes, thus recapitulating the involuting phase of hemangioma. In the present study, we have elucidated the intrinsic mechanisms of adipocyte differentiation using hemangioma-derived stem cells (hemSCs). We found that platelet-derived growth factor (PDGF) is elevated during the proliferating phase and may inhibit adipocyte differentiation. hemSCs expressed high levels of PDGF-B and showed sustained tyrosine phosphorylation of PDGF receptors under basal (unstimulated) conditions. Inhibition of PDGF receptor signaling caused enhanced adipogenesis in hemSCs. Furthermore, exposure of hemSCs to exogenous PDGF-BB reduced the fat content and the expression of adipocyte-specific transcription factors. We also show that these autogenous inhibitory effects are mediated by PDGF receptor-? signaling. In summary, this study identifies PDGF signaling as an intrinsic negative regulator of hemangioma involution and highlights the therapeutic potential of disrupting PDGF signaling for the treatment of hemangiomas. PMID:22717583

Roach, E E; Chakrabarti, R; Park, N I; Keats, E C; Yip, J; Chan, N G; Khan, Z A

2012-01-01

280

COSMC Is Overexpressed in Proliferating Infantile Hemangioma and Enhances Endothelial Cell Growth via VEGFR2  

PubMed Central

Infantile hemangiomas are localized lesions comprised primarily of aberrant endothelial cells. COSMC plays a crucial role in blood vessel formation and is characterized as a molecular chaperone of T-synthase which catalyzes the synthesis of T antigen (Gal?1,3GalNAc). T antigen expression is associated with tumor malignancy in many cancers. However, roles of COSMC in infantile hemangioma are still unclear. In this study, immunohistochemistry showed that COSMC was upregulated in proliferating hemangiomas compared with involuted hemangiomas. Higher levels of T antigen expression were also observed in the proliferating hemangioma. Overexpression of COSMC significantly enhanced cell growth and phosphorylation of AKT and ERK in human umbilical vein endothelial cells (HUVECs). Conversely, knockdown of COSMC with siRNA inhibited endothelial cell growth. Mechanistic investigation showed that O-glycans were present on VEGFR2 and these structures were modulated by COSMC. Furthermore, VEGFR2 degradation was delayed by COSMC overexpression and facilitated by COSMC knockdown. We also showed that COSMC was able to regulate VEGF-triggered phosphorylation of VEGFR2. Our results suggest that COSMC is a novel regulator for VEGFR2 signaling in endothelial cells and dysregulation of COSMC expression may contribute to the pathogenesis of hemangioma.

Lee, Jian-Jr; Huang, Miao-Juei; Huang, John; Hung, Ji-Shiang; Chen, Ming-Ting; Huang, Min-Chuan

2013-01-01

281

Coexistence of cavernous hemangioma and other vascular malformations of the orbit. A report of three cases.  

PubMed

Coexistence of orbital cavernous hemangioma and other vascular malformations is unusual and few cases have been reported. We describe the clinical and radiological features of three cases of orbital cavernous hemangiomas associated with other vascular malformations, selected reviewing a series of 181 cases of cavernous hemangiomas. All patients were males (age ranging from 43 to 67 years) without vascular systemic disorders and/or a clinical syndrome. They experienced slow progressive exophthalmos. One of them developed acute pulsatile proptosis (case 2), while another experienced slow progressive diplopia (case 3). In one case vascular lesions were bilateral (case 3) and in two patients two different lesions coexisted in the same orbit (cases 1 and 2). All patients underwent surgical excision, which was partial in two cases. Two patients had cavernous hemangiomas in association with a venous malformation (a varix in case 1 and a lymphangioma in case 2), while in the other ones (case 3) cavernous hemangioma was associated with a low-flow arteriovenous malformation. No patient denied visual impairment postoperatively. Few cases of orbital cavernous hemangiomas coexisting with other vascular malformations have been reported in the literature. This entity seems to be an association of different variants of orbital vascular malformations, presenting with a wide spectrum of clinical forms and probably with the same pathogenesis. PMID:24750713

Strianese, Diego; Napoli, Manuela; Russo, Carmela; D'Errico, Arianna; Scotti, Nadia; Puoti, Gianfranco; Bonavolontà, Giulio; Tranfa, Fausto; Briganti, Francesco

2014-04-30

282

Evidence by molecular profiling for a placental origin of infantile hemangioma  

PubMed Central

The origin of the pathogenic endothelial cells in common infantile hemangioma is unknown. We show here that the transcriptomes of human placenta and infantile hemangioma are sufficiently similar to suggest a placental origin for this tumor, expanding on recent immunophenotypical studies that have suggested this possibility [North, P. E., et al. (2001) Arch. Dermatol. 137, 559-570]. The transcriptomes of placenta, hemangioma, and eight normal and diseased tissues were compared by hierarchical and nonhierarchical clustering analysis of >7,800 genes. We found that the level of transcriptome similarity between placenta and hemangioma exceeded that of any other tissue compared and paralleled that observed between a given tissue and its derived tumor, such as normal and cancerous lung. The degree of similarity was even greater when a subset of endothelial cell-specific genes was analyzed. Genes preferentially expressed in both placenta and hemangiomas were identified, including 17-? hydroxysteroid dehydrogenase type 2 and tissue factor pathway inhibitor 2. These data demonstrate the value of global molecular profiling of tissues as a tool for hypothesis-driven research. Furthermore, it suggests that the unique self-limited growth of infantile hemangioma may, in fact, mirror the lifetime of placental endothelium.

Barnes, Carmen M.; Huang, Sui; Kaipainen, Arja; Sanoudou, Despina; Chen, Emy J.; Eichler, Gabriel S.; Guo, Yuchun; Yu, Ying; Ingber, Donald E.; Mulliken, John B.; Beggs, Alan H.; Folkman, Judah; Fishman, Steven J.

2005-01-01

283

Hepatitis B Vaccine  

MedlinePLUS

... as a combination product containing Hepatitis A Vaccine, Hepatitis B Vaccine) ... What is hepatitis B?Hepatitis B is a serious infection that affects the liver. It is caused by the hepatitis B virus. ...

284

Propranolol treatment of infantile hemangioma endothelial cells: A molecular analysis  

PubMed Central

Infantile hemangiomas (IHs) are non-malignant, largely cutaneous vascular tumors affecting approximately 5–10% of children to varying degrees. During the first year of life, these tumors are strongly proliferative, reaching an average size ranging from 2 to 20 cm. These lesions subsequently stabilize, undergo a spontaneous slow involution and are fully regressed by 5 to 10 years of age. Systemic treatment of infants with the non-selective ?-adrenergic receptor blocker, propranolol, has demonstrated remarkable efficacy in reducing the size and appearance of IHs. However, the mechanism by which this occurs is largely unknown. In this study, we sought to understand the molecular mechanisms underlying the effectiveness of ? blocker treatment in IHs. Our data reveal that propranolol treatment of IH endothelial cells, as well as a panel of normal primary endothelial cells, blocks endothelial cell proliferation, migration, and formation of the actin cytoskeleton coincident with alterations in vascular endothelial growth factor receptor-2 (VEGFR-2), p38 and cofilin signaling. Moreover, propranolol induces major alterations in the protein levels of key cyclins and cyclin-dependent kinase inhibitors, and modulates global gene expression patterns with a particular affect on genes involved in lipid/sterol metabolism, cell cycle regulation, angiogenesis and ubiquitination. Interestingly, the effects of propranolol were endothelial cell-type independent, affecting the properties of IH endothelial cells at similar levels to that observed in neonatal dermal microvascular and coronary artery endothelial cells. This data suggests that while propranolol markedly inhibits hemangioma and normal endothelial cell function, its lack of endothelial cell specificity hints that the efficacy of this drug in the treatment of IHs may be more complex than simply blockage of endothelial function as previously believed.

STILES, JESSICA; AMAYA, CLARISSA; PHAM, ROBERT; ROWNTREE, REBECCA K.; LACAZE, MARY; MULNE, ARLYNN; BISCHOFF, JOYCE; KOKTA, VICTOR; BOUCHERON, LAURA E.; MITCHELL, DIANNE C.; BRYAN, BRAD A.

2012-01-01

285

Hepatic incidentalomas.  

PubMed

Recent advances in multidetector-row computed tomography, magnetic resonance imaging, and ultrasonography have led to the detection of incidental hepatic lesions in both the oncology and nononcology patient population that in the past remained undiscovered. These incidental hepatic lesions have created a management dilemma for both clinicians and radiologists. In this review, guidelines concerning the diagnosis and management of some of the more common hepatic incidentalomas are presented. PMID:21333779

Gore, Richard M; Newmark, Geraldine M; Thakrar, Kiran H; Mehta, Uday K; Berlin, Jonathan W

2011-03-01

286

A case of congenital giant gallbladder with massive hydrops mimicking celiac cyst  

PubMed Central

We present a case of a 55-year-old female who suffered from a mass in the right upper abdomen, which had been present for over six months. Pre-operative blood examinations, including tumor markers, were normal. Initially, the admitting diagnosis was a giant celiac cyst, due to its liquid cystic appearance and large size (approximately 30.0×18.0 cm), visible in the hepatic region under ultrasound. Following the discovery of a cystic duct during surgery, the diagnosis was corrected to be a giant gallbladder. As no obstructive matter was observed, the giant gallbladder was considered to be congenital.

ZONG, LIANG; CHEN, PING; WANG, LEI; HE, CHUNLAN; WANG, GUANGYAO; JIANG, JIAN; WANG, HAO

2013-01-01

287

Hepatic ischemia  

MedlinePLUS

... ischemia. Such conditions may include: Abnormal heart rhythms Dehydration Heart failure Infection Severe bleeding Other causes may include: Blood clots in the main artery to the liver (hepatic ...

288

Giant congenital melanocytic nevus*  

PubMed Central

Giant congenital melanocytic nevus is usually defined as a melanocytic lesion present at birth that will reach a diameter ? 20 cm in adulthood. Its incidence is estimated in <1:20,000 newborns. Despite its rarity, this lesion is important because it may associate with severe complications such as malignant melanoma, affect the central nervous system (neurocutaneous melanosis), and have major psychosocial impact on the patient and his family due to its unsightly appearance. Giant congenital melanocytic nevus generally presents as a brown lesion, with flat or mammilated surface, well-demarcated borders and hypertrichosis. Congenital melanocytic nevus is primarily a clinical diagnosis. However, congenital nevi are histologically distinguished from acquired nevi mainly by their larger size, the spread of the nevus cells to the deep layers of the skin and by their more varied architecture and morphology. Although giant congenital melanocytic nevus is recognized as a risk factor for the development of melanoma, the precise magnitude of this risk is still controversial. The estimated lifetime risk of developing melanoma varies from 5 to 10%. On account of these uncertainties and the size of the lesions, the management of giant congenital melanocytic nevus needs individualization. Treatment may include surgical and non-surgical procedures, psychological intervention and/or clinical follow-up, with special attention to changes in color, texture or on the surface of the lesion. The only absolute indication for surgery in giant congenital melanocytic nevus is the development of a malignant neoplasm on the lesion.

Viana, Ana Carolina Leite; Gontijo, Bernardo; Bittencourt, Flavia Vasques

2013-01-01

289

Cavernous Hemangioma-Like Kaposi Sarcoma: Histomorphologic Features and Differential Diagnosis  

PubMed Central

Aim. Cavernous hemangioma-like Kaposi sarcoma is a rare morphologic type of Kaposi sarcoma. So far there are no cases in the literature defining the histological features of this morphologic spectrum in detail. In this study we presented two classical-type cutaneous Kaposi sarcoma cases with histologic findings resembling cavernous hemangioma in company with clinical and histopathological data. Cases. One hundred and eighty-five classical-type cutaneous Kaposi sarcoma lesions in 79 patients were assessed retrospectively in terms of histopathological features. Findings of two cases showing features of cavernous hemangioma-like Kaposi sarcoma whose clinical data could be accessed were presented in accompany with the literature data. Both cases were detected to have bluish-purple, protruded, irregularly bordered cutaneous lesions. Histopathological examination revealed a lesion formed by cavernous hemangioma-like vascular structures organized in a lobular pattern that became dilated and filled with blood. Typical histological findings of early-stage KS, consisting of mononuclear inflammation, extravasated erythrocytes, and a few immature vascular structures in superficial dermis, were observed. All cases were serologically HIV-1 negative. A positive reaction with HHV-8, CD31, CD34, and D2-40 monoclonal antibodies was identified at both cavernous hemangioma-like areas and in immature vascular structures. Results. Cavernous hemangioma-like Kaposi sarcoma is a rare Kaposi sarcoma variant presenting with diagnostic challenges, that may be confused with hemangioma. As characteristic morphological features may not be observed in every case, it is important for diagnostic purposes to show immunohistochemical HHV-8 positivity in this variant.

Onak Kandemir, Nilufer; Barut, Figen; Dogan Gun, Banu; Solak Tekin, Nilgun; Hallac Keser, Sevinc; Oguz Ozdamar, Sukru

2013-01-01

290

Diagnosis and management of hepatic focal nodular hyperplasia  

PubMed Central

Focal nodular hyperplasia (FNH) is the second most common benign tumor of the liver, after hemangioma. It is generally found incidentally and is most common in reproductive-aged women, but it also affects males and can be diagnosed at any age. Patients are rarely symptomatic, but FNH sometimes causes epigastric or right upper quadrant pain. The main clinical task is to differentiate it from other hypervascular hepatic lesions such as hepatic adenoma, hepatocellular carcinoma, or hypervascular metastases, but invasive diagnostic procedures can generally be avoided with the appropriate use of imaging techniques. Magnetic resonance (MR) imaging is more sensitive and specific than conventional ultrasonography (US) or computed tomography (CT), but Doppler US and contrast-enhanced US (CEUS) can greatly improve the accuracy in the diagnosis of FNH. Once a correct diagnosis has been made, in most cases there is no indication for surgery, and treatment includes conservative clinical follow-up in asymptomatic patients.

Venturi, A.; Piscaglia, F.; Vidili, G.; Flori, S.; Righini, R.; Golfieri, R.; Bolondi, L.

2007-01-01

291

Hepatic cavitation  

Microsoft Academic Search

Sonographically visible microbubbles attributable to cavitation effects have been observed in bile (within the gallbladder), in hepatic vessels, and within the liver of patients undergoing biliary lithotripsy. Cavitation effects are believed to contribute to stone fragmentation and possibly tissue injury during lithotripsy. To study the latter, the relationship between intraparenchymal hepatic cavitation and serum transaminase activity and clinical follow-up was

Leslie E. Forer; William J. Davros; Joanne Goldberg; Firas Al-Kawas; Brian S. Garra; Wendelin Hayes; Robert K. Zeman

1992-01-01

292

Hepatitis B  

MedlinePLUS

By 1970, the hepatitis B virus had been identified and shown to be a major cause of acute and chronic liver disease. Reliable but ... insensitive tests for the virus were newly available. Hepatitis B was the most common cause of acute liver ...

293

Giant-cell arteritis.  

PubMed

Giant-cell or temporal arteritis is a generalized vasculitis that predominantly affects large- and medium-sized arteries in people over 50 years of age. The illness is commonly characterized by the initial symptoms of headache, temporal artery tenderness or pulselessness, musculoskeletal pain, fever, and fatigue. The most dreaded consequence of giant-cell arteritis is visual loss, which is usually irreversible on presentation. Giant-cell arteritis may present with unusual clinical manifestations such as lip, scalp, and tongue necrosis, carpal tunnel syndrome, claudication of the limbs, strokes, angina pectoris, myocardial infarction, hematuria, cough, or other CNS symptoms. The etiology of the disease is unknown. Emergency physicians are usually familiar with the more common clinical symptoms but one must consider the unusual manifestations of the disease, because early recognition and initiation of therapy (steroids) decrease morbidity and can prevent blindness. PMID:3794280

Sherard, R K; Coleridge, S T

1986-01-01

294

Giant cutaneous horn.  

PubMed

A 53-year-old male presented with a giant cutaneous horn over the left leg. Cutaneous horn was excised and primary closure of the defect was done under spinal anesthesia. Histopathology showed underlying seborrheic keratosis. Cutaneous horn has been noticed on top of many clinical conditions of diverse etiology, such as actinic keratoses, wart, molluscum contagiosum, seborrheic keratoses, keratoacanthoma, basal cell and squamous cell carcinoma. We report a patient with giant cutaneous horn on the leg successfully treated by excision and wound closure. PMID:19882036

M, Kumaresan; Kumar, Pramod; Pai, Manohar Varadharaj

2008-01-01

295

How giant planets cool  

NASA Astrophysics Data System (ADS)

Understanding how giant planets cool is key to the study of their interior structure, composition and hence formation. I will review how the observed luminosities of Jupiter, Saturn, Uranus and Neptune may be accounted for, mostly by convective transport of heat limited by the atmospheric lip, but with several complications (sedimentation of helium droplets, gradients of composition...). Conversely, I will show that the the cooling of strongly irradiated giant planets ("Pegasids") is limited by heat transport in a thick external radiative zone with a possibility of a significant dissipation of heat due to tides. In all cases, both radiative transport and atmospheric/interior dynamics play crucial roles and require further studies.

Guillot, T.

2006-12-01

296

Giant resonance decay  

SciTech Connect

Decay studies of giant multipole resonances are discussed, emphasizing the role of Coulomb excitation with intermediate energy heavy ions, which can provide very large cross sections for both isoscalar and isovector resonances. We discuss measurement of the photon decay of one and two phonon giant resonances, reporting results where available. It is pointed out throughout the presentation that the use of E1 photons as a tag'' provides a means to observe weakly excited resonances that cannot be observed in the singles spectra. 30 refs., 16 figs., 1 tab.

Beene, J.R.; Bertrand, F.E.

1990-01-01

297

Giant bullae emphysema.  

PubMed

Bullous lung disease, a variant of the emphysematous process, can come in different forms and presentations, both histologically and radiographically. Giant bulla (GB) is the rarest form of bullous lung disease. Onset of disease to duration to symptoms is unclear. Presenting symptoms include cough, chest pain, and progressive dyspnea. Differentiating between other cystic lung diseases or developmental/congenital anomalies is vital. While most patients with bullous lung disease can be managed medically, those with giant bulla should be referred for careful surgical evaluation. The authors describe GB, highlight the role of imaging, and discuss the evaluation and pathophysiology of this rare presentation. PMID:23925735

Ghattas, Christian; Barreiro, Timothy J; Gemmel, David J

2013-10-01

298

Anesthesia in an adult patient with tracheal hemangiomas: one-lung ventilation for lung lobectomy.  

PubMed

Primary tracheal tumors are rare in adults, and careful airway management is required during anesthesia for affected patients. We report the case of a patient with tracheal hemangiomas undergoing nontracheal operation. A 61-year-old woman was scheduled for a lung operation. During preoperative examination, hemangiomas were detected on the tracheal mucosa. As she was asymptomatic and the degree of airway stenosis was small, treatment was not required for the hemangiomas, and left upper lobectomy for lung cancer was scheduled. After induction of general anesthesia, a regular tracheal tube was inserted under fiberoptic bronchoscopy, with care taken to prevent damage to the hemangiomas. An endobronchial blocker was inserted for one-lung ventilation. The operation was performed uneventfully, and the tracheal tube was replaced postoperatively with a laryngeal mask airway while the patient was under deep anesthesia and neuromuscular blockade. The mask was removed after confirming lack of bleeding from the hemangiomas. No hypoxia or other complications occurred during or after the operation. PMID:22116259

Tsujikawa, Shogo; Okutani, Ryu; Oda, Yutaka

2012-04-01

299

Cellular markers that distinguish the phases of hemangioma during infancy and childhood.  

PubMed Central

Hemangiomas, localized tumors of blood vessels, appear in approximately 10-12% of Caucasian infants. These lesions are characterized by a rapid proliferation of capillaries for the first year (proliferating phase), followed by slow, inevitable, regression of the tumor over the ensuing 1-5 yr (involuting phase), and continual improvement until 6-12 yr of age (involuted phase). To delineate the clinically observed growth phases of hemangiomas at a cellular level, we undertook an immunohistochemical analysis using nine independent markers. The proliferating phase was defined by high expression of proliferating cell nuclear antigen, type IV collagenase, and vascular endothelial growth factor. Elevated expression of the tissue inhibitor of metalloproteinase, TIMP 1, an inhibitor of new blood vessel formation, was observed exclusively in the involuting phase. High expression of basic fibroblast growth factor (bFGF) and urokinase was present in the proliferating and involuting phases. There was coexpression of bFGF and endothelial phenotypic markers CD31 and von Willebrand factor in the proliferating phase. These results provide an objective basis for staging hemangiomas and may be used to evaluate pharmacological agents, such as corticosteroids and interferon alfa-2a, which accelerate regression of hemangiomas. By contrast, vascular malformations do not express proliferating cell nuclear antigen, vascular endothelial growth factor, bFGF, type IV collagenase, and urokinase. These data demonstrate immunohistochemical differences between proliferating hemangiomas and vascular malformations which reflect the biological distinctions between these vascular lesions. Images

Takahashi, K; Mulliken, J B; Kozakewich, H P; Rogers, R A; Folkman, J; Ezekowitz, R A

1994-01-01

300

Photodynamic therapy suppresses tumor growth in an in vivo model of human hemangioma.  

PubMed

The authors investigated the efficacy of photodynamic therapy against infantile hemangioma using a hemangioma animal model. Eighty-three hemangioma specimens from five children were implanted into nude mice. The gross and volume changes of the implants were evaluated for up to 13 weeks. The histological change of the implant was evaluated at 5 weeks after transplantation. Photodynamic therapy was performed between 6 and 10 weeks after transplantation. The photosensitizer uptake of the implant was evaluated at 24 h after photosensitizer administration. The implant response was evaluated at 0, 12, and 24 h after light delivery. The change in ATF3 levels, a transcription factor induced under severe hypoxic conditions, was investigated immediately after treatment. The implant volume increased slowly during the first 4 weeks and then involuted. At 5 weeks after transplantation, plump endothelial cells formed tightly packed sinusoidal channels, and the endothelial cells were positive for CD31 and GLUT1 expression. At 24 h after photosensitizer administration, confocal analysis showed that the photosensitizer was present within CD31-positive cells. The implant volume was significantly decreased in the treated implants compared with the untreated implants (p < 0.0001). At 24 h after light delivery, most cells had collapsed. ATF3 expression increased gradually and then reached a maximum level at 4 h after treatment. Photodynamic therapy was effective in the treatment of infantile hemangioma. Apoptosis, a major mechanism of hemangioma destruction in the early phase, might be caused by ischemic injury as well as direct effects of photodynamic therapy. PMID:23784382

Choi, Jaehoon; Kim, Woo Jung; Park, Sang Woo; Xu, Lianji; Kim, Sang-Hyon; Min, Hye Sook; Kwon, Geun-Yong; Cho, Chung-Hyun; Kim, Sukwha; Choi, Tae Hyun

2014-01-01

301

Multiple cavernous hemangiomas of the skull with dural tail sign: a case report and literature review  

PubMed Central

Background Primary intraosseous cavernous hemangioma is a rare bony tumor. To date, only 9 cases of multiple lesions and 2 cases with a dural tail sign have been reported. Case presentation Here, we present a case of multiple cavernous hemangiomas of the skull with dural tail sign in a 24-year-old man. No abnormalities were observed in the right orbit by craniography, but frontal bone destruction was unintentionally discovered. Computed tomography and magnetic resonance imaging demonstrated multiple intraosseous lesions that destroyed the surrounding bone and intracranial extension. Total resection of the two lesions and cranioplasty were performed. Histological examination confirmed the lesions as a cavernous hemangioma. Conclusion Cavernous hemangioma is a rare bony tumor that should be considered in the differential diagnosis of skull tumors. Resection of all lesions should be performed on patients with multiple cavernous hemangiomas, and these patients should have regular follow-up examinations. Based on this case, and our literature review, we found that outcomes are usually very good.

2013-01-01

302

[Capillary hemangiomas of the lung presenting as ground glass opacities by high resolution computed tomography].  

PubMed

Capillary hemangiomas are often seen on the skin, mucosa, liver and other organs, but they are very rare in the lung. We report 3 cases of capillary hemangioma of the lung that presented as ground glass opacities(GGO) by computed tomography( CT). Mixed GGO was observed in 2 cases that increased in size after the follow-up period. The remaining case involved a pure GGO that was stable in size. They were suspected to be bronchioloalveolar carcinoma( BAC) based on the CT findings, and video assisted thoracoscopic surgery was performed in all 3 cases. It is difficult to distinguish capillary hemangioma from other malignant diseases such as BAC based on CT findings. As high resolution CT becomes more widely used, GGOs are becoming more frequently detected. When GGOs are detected by CT, capillary hemangiomas should be included in the differential diagnosis. Intraoperatively, an important surgical finding for capillary hemangiomas is that they became impalpable after repeated palpation. This surgical finding can be useful when identifying the region for biopsy and resection. PMID:23117354

Shimada, Yoshifumi; Murakawa, Tomohiro; Sano, Atsushi; Fukami, Takeshi; Yoshida, Yukihiro; Inoue, Yuta; Morita, Shigeki; Fukayama, Masashi; Nakajima, Jun

2012-11-01

303

Spontaneous hemorrhage from orbital cavernous hemangioma resulting in sudden onset of ophthalmopathy in an adult--case report.  

PubMed

A 61-year-old woman presented with a very rare case of spontaneous bleeding from an orbital cavernous hemangioma manifesting as sudden onset of ophthalmic pain, proptosis, diplopia, and nausea. Magnetic resonance (MR) imaging and computed tomography (CT) revealed an intraconal, well-demarcated cystic mass with hemorrhage. The mass was immediately removed through a transcranial approach. Histological examination showed that the mass was a cavernous hemangioma. Ophthalmopathy was resolved by surgery. Orbital cavernous hemangioma is very common in adults, but spontaneous bleeding is extremely rare relative to intracranial cavernous hemangiomas. This rare case emphasizes the importance of careful neuroimaging evaluation with MR imaging and CT for diagnosing orbital cavernous hemangioma associated with spontaneous bleeding. PMID:23095267

Yamamoto, Junkoh; Takahashi, Mayu; Nakano, Yoshiteru; Saito, Takeshi; Kitagawa, Takehiro; Ueta, Kunihiro; Miyaoka, Ryo; Nishizawa, Shigeru

2012-01-01

304

Hepatic encephalopathy.  

PubMed

Hepatic encephalopathy is a serious and potentially fatal complication of both acute and chronic liver disease, arising as a result of hepatocellular failure, cirrhosis and/or portal-systemic shunting (Ferenci et al, 2002). It reflects a broad spectrum of neuropsychiatric abnormalities, encompassing a range of defects in psychomotor, locomotive, cognitive, emotional and behavioural functions (Prakash and Mullen, 2010). Hepatic encephalopathy is either overt or minimal. While overt hepatic encephalopathy can be diagnosed using bedside clinical tests, minimal hepatic encephalopathy is clinically invisible and requires psychometric testing to diagnose. The rising prevalence of end-stage viral hepatitis-related liver disease, coupled with the growing problem of alcoholic and non-alcoholic fatty liver disease, has significantly increased the burden of disease from cirrhosis (Mooney et al, 2007; Fleming et al, 2008), so recognition and appropriate management of the manifestations of decompensating cirrhosis (including hepatic encephalopathy) is essential. Hepatic encephalopathy has a substantial societal burden because of its impact on survival, quality of life and daily functioning, including an impaired ability to drive, leaving patients especially vulnerable to road traffic accidents (Ferenci et al, 2002; Prakash and Mullen, 2010). PMID:22504749

Patel, D; McPhail, M J W; Cobbold, J F L; Taylor-Robinson, S D

2012-02-01

305

Giant funicular intrapharyngeal schwannoma  

Microsoft Academic Search

Background. Schwannoma is a rare solitary tumor of Schwann cell origin. The Schwann cell surrounds peripheral nerve tissue and is believed to originate from neural crest. Sur- gery presents main treatment for patients with schwannoma. Methods. This is a report of a rare case of giant and bizarre- shaped intrapharyngeal schwannoma. A 38-year-old woman with a very large schwannoma (25

Milan B. Jovanovic; Zoran S. Milutinovic; Mile S. Strbac; Jelena V. Perovic; Sanja A. Milenkovic

2008-01-01

306

Finite size giant magnon  

SciTech Connect

The quantization of the giant magnon away from the infinite size limit is discussed. We argue that this quantization inevitably leads to string theory on a Z{sub M} orbifold of S{sup 5}. This is shown explicitly and examined in detail in the near plane-wave limit.

Ramadanovic, Bojan; Semenoff, Gordon W. [Department of Physics and Astronomy, University of British Columbia, Vancouver, British Columbia, V6T 1Z1 (Canada)

2009-06-15

307

Giant adrenal myelolipoma  

PubMed Central

A fifty-two years old male presenting with a history of abdominal pain of six months duration was found on investigation to have a large non-functioning adrenal mass. Adrenal myelolipoma was diagnosed preoperatively and surgical resection was carried out. Only a small number of cases of giant adrenal myelolipoma (>3500 grams) have been reported. A brief review of literature is done.

Gautam, S.C.; Raafat, H.; Sriganesh, S.; Zaffar, I.; Olude, I.; Komolafe, F.; Qazi, F.

2013-01-01

308

Giant urethral calculus  

PubMed Central

Primary urethral calculus is rarely seen and is usually encountered in men with urethral stricture or diverticulum. We present a case of giant urethral calculus secondary to a urethral stricture in a man. The patient was treated with calculus extraction with end to end urethroplasty.

Kotkar, Kunal; Thakkar, Ravi; Songra, MC

2011-01-01

309

A Council of Giants  

NASA Astrophysics Data System (ADS)

Distances and near-infrared luminosities of the brightest galaxies in the Local Volume have been re-evaluated in order to gain a fully homogeneous collection of data for elucidating the framework of the Local Sheet and its relevance to Local Group evolution. It is demonstrated that the Local Sheet is both geometrically and dynamically distinct from the Local Supercluster and that the evolution of the Sheet and Local Group were probably interconnected. The Sheet is inclined by 8° with respect to the Local Supercluster, and the dispersion of giant members about the mid-plane is only 230 kpc. A `Council of Giants' with a radius of 3.75 Mpc encompasses the Local Group, demarcating a clear upper limit to the realm of influence of the Local Group. The only two giant elliptical galaxies in the Sheet sit on opposite sides of the Council, raising the possibility that they have somehow shepherded the evolution of the Local Group. The position vector of the Andromeda galaxy with respect to the Milky Way deviates only 11° from the Sheet plane and only 11° from the projected axis of the ellipticals. The Local Group appears to be moving away from a ridge in the potential surface of the Council on a path parallel to the elliptical axis. Spin directions of the giants in the Council are distributed over the sky in a pattern which is very different from that of giants beyond, possibly in reaction to the central mass asymmetry that developed into the Local Group. By matching matter densities of Group and Council giants, the edge of the volume of space most likely to have contributed to the development of the Local Group is shown to be very close to where gravitational forces from the Local Group and the Council balance. The boundary specification reveals that the Local Sheet formed out of a density perturbation of very low amplitude (˜10 per cent), but that normal matter was incorporated into galaxies with relatively high efficiency (˜40 per cent). It appears that the development of the giants of the Local Sheet was guided by a pre-existing flattened framework of matter.

McCall, Marshall L.

2014-05-01

310

Hepatic Encephalopathy  

PubMed Central

Chronic liver disease and cirrhosis affect hundreds of millions of patients all over the world. The majority of patients with cirrhosis will eventually develop complications related to portal hypertension. One of these recurrent and difficult to treat complications is hepatic encephalopathy. Studies have indicated that overt hepatic encephalopathy affects 30 to 45% of patients with cirrhosis and a higher percentage may be affected by minimal degree of encephalopathy. All of these factors add to the impact of hepatic encephalopathy on the healthcare system and presents a major challenge to the gastroenterologist, hospitalist and primary care physician.

Bleibel, Wissam; Al-Osaimi, Abdullah M. S.

2012-01-01

311

Technical strategies for en bloc resection and immediate reconstruction in hemangioma of the frontal bone.  

PubMed

Hemangioma of the skull is a benign solitary tumor, often found in the frontal or parietal area. A hemangioma lesion typically involves the outer table rather than the inner, but its complete removal at the diploe level is difficult. Full-thickness resection at the calvaria is often needed to ensure a free margin, but it will leave a bony defect that requires reconstruction. Although curettage and covering of the lesion with alloplastic material are a simple treatment option for hemangioma of the skull, it does not always prevent recurrence. Hence, complete resection is needed. As our technical strategies for reconstruction, we organize a split calvarial bone graft if a defect is near the frontal sinus and calcium phosphate cement if it is somewhat far from the sinus. PMID:24448536

Uemura, Tetsuji; Sawai, Kiwako; Kikuchi, Mamoru; Masuoka, Jun; Matsushima, Toshio

2014-07-01

312

Co-occurrence of intraoral hemangioma and port wine stain: A rare case  

PubMed Central

Hemangiomas are neoplastic proliferations of endothelial cells, characterized by a period of growth after birth, and eventual spontaneous involution. The course can be uneventful with spontaneous resolution; or it may be marked by complications such as infection, bleeding, ulceration, visual defects and feeding difficulties. Apart from these, rare life-threatening complications such as congestive heart failure and consumption coagulopathy may also be seen. Although hemangiomas commonly occur in the head and neck region, intraoral occurrence is relatively rare. A port wine stain is defined as a macular telangiectatic patch which is present at birth and remains throughout life. They may be localized or extensive, affecting a whole limb. This article reports a rare case of co-occurrence of port wine stain with intraoral hemangioma.

Rao, Prasanna Kumar; Bejai, Vishal; Rao, Sanath; Shetty, Shishir Ram

2012-01-01

313

Nd:YAG laser treatment for laryngeal and hypopharyngeal hemangiomas: a new technique.  

PubMed

The treatment of laryngeal and hypopharyngeal hemangiomas is indicated when they are symptomatic, causing dysphagia, recurrent bleeding, or airway obstruction. These tumors are found in the glottis, supraglottic larynx, and hypopharynx. Histologically, they are considered as mixed or cavernous-type hemangiomas. By utilizing a glass slide to compress the lesion, its thickness and blood flow are reduced. The tumor can then be laser-photocoagulated with less energy, with the glass slide used as a laser platform. These conditions optimize the benefits of laser ablation while minimizing the adverse heat sink effects to the surrounding healthy tissue. We present three patients with hemangiomas of the larynx and hypopharynx who were treated with this technique. The details of the technique in each case will be presented with the objective of improving the care of these unusual and challenging tumors. PMID:8678425

Yellin, S A; LaBruna, A; Anand, V K

1996-07-01

314

Endoscopic endonasal removal of a cavernous hemangioma of the orbital apex  

PubMed Central

Background: Cavernous hemangioma are the most common benign lesions of the orbit. Their surgical resection is still challenging and several surgical approaches have been proposed. Case Description: We present the case of a 59-year-old woman with a cavernous hemangioma of the orbital apex, which was diagnosed incidentally. The hemangioma was extraconal and involved mainly the medial orbital apex; it also extended to the pterygoid fossa, to the middle fossa, to the maxillary and sphenoid sinuses. The surgical resection was performed by a pure endoscopic transphenoidal, transmaxillary, transethmoidal approach, achieving a total removal. The patient had a transient and incomplete paresis of the VI cranial nerve on the left side and did not experience other postoperative complications. Conclusion: The endoscopic endonasal approach proved successful in the management of this case and it should be considered in the surgical management of extraconal orbital apex lesions with medial or inferior extension.

Locatelli, Marco; Carrabba, Giorgio; Guastella, Claudio; Gaini, Sergio M.; Spagnoli, Diego

2011-01-01

315

Percutaneous vertebroplasty in symptomatic hemangioma versus osteoporotic compression fracture  

PubMed Central

Background: Percutaneous vertebroplasty (PVP) is more commonly used for osteoporotic compression fractures (OCFs) and osteolytic vertebral body tumors. This study aimed to study the differences between OCFs and vertebral hemangiomas (VHs) treated with PVP. Materials and Methods: Between September 2007 and January 2010, we prospectively treated 28 consecutive patients of OCFs (43 recently symptomatic OCFs) and 24 cases of VHs (26 VHs). We used visual analogue scale (VAS) pain and Oswestry Disability Index (ODI) to evaluate the patients. The followup period in group 1 and 2 were 25.1 months (range 12 - 31 months) and 21.3 months (range 14 - 28 months), respectively. Comparison of means was carried out with the Chi Square Tests, t-test, and N Par-Test for multiple comparisons, whenever appropriate. The level of statistical significance was set at P < 0.05. Results: Following PVP the VAS score decreased to 4.57 and 4.17 in group 1 and 2, respectively. The ODI scores were 32.5% and 30%, respectively. This decrease in ODI scores lasted throughout the followup period. Conclusions: Although the preoperative scores were significantly different between group 1 and 2, there was no significant difference between two groups following the PVP.

Omidi-Kashani, Farzad; Hasankhani, Ebrahim G; Akhlaghi, Saeed; Golhasani-Keshtan, Farideh; Toosi, Katayoun Z

2013-01-01

316

Late rebound of infantile hemangioma after cessation of oral propranolol.  

PubMed

Propranolol has become the first line of treatment for infantile hemangiomas (IHs), with a high response rate, but rebound growth after cessation of propranolol has been reported, primarily in the first year of life. We sought to determine the frequency and associated factors leading to late regrowth after successful treatment at an age when the proliferative phase has usually ceased. We retrospectively reviewed the clinical charts, serial photographs, and radiologic images of children with rebound IH occurring after the age of 15 months after a successful course of oral propranolol averaging 2.6 mg/kg/day (range 2-3 mg/kg/day). Thirteen (10 female, 3 male) of 212 patients (6%) treated with oral propranolol since 2008 were evaluated. The mean age at the start of treatment was 5.3 months (range 1.8-13 months), and an average of 10.3 months (range 4.5-16 months) of treatment was given. It took an average of 5.3 months (range 1-13.8 months) for a significant rebound to appear. Late rebound after successful propranolol indicates a prolonged proliferation phase of IH even after 15 months of age. This is compared with previous reports of rebound, which occurred primarily in infants younger than 1 year old. Late proliferation can occur in localized, small, mixed, and deep IH, even after several months of a positive response to propranolol. A second course of propranolol readily controlled the recurrence. PMID:24016283

Shehata, Nancy; Powell, Julie; Dubois, Josée; Hatami, Afshin; Rousseau, Elizabeth; Ondrejchak, Sandra; McCuaig, Catherine

2013-01-01

317

Bilateral ovarian capillary hemangioma with stromal luteinization and hyperandrogenism.  

PubMed

A 77-year-old female presented to the outpatient clinic with a six-month history of left lower quadrant abdominal fullness and pressure. Serum levels included free testosterone 3.8 pg/mL (normal 0-1.8 pg/mL) and testosterone 259 ng/dL (normal 3-41 ng/dL). Magnetic resonance imaging of the pelvis showed bilateral small ovarian cystic masses with marked, progressive enhancement, and restriction of diffusion. Laparoscopic bilateral salpingo-oophorectomy was performed and showed left and right ovarian hemorrhagic masses measuring 2.1 cm and 0.6 cm respectively. The histology showed benign vascular lesions composed of small capillary vessels with a rim of luteinized stromal cells. The luteinized cells were strongly positive for inhibin A. The endothelial cells were negative for estrogen receptor and progesterone receptor. To our knowledge, this is the first reported case of bilateral ovarian hemangioma with stromal luteinization and hyperandrogenism. PMID:24247806

Huang, Richard Sheng Poe; Covinsky, Michael; Zhang, Songlin

2013-01-01

318

Cavernous sinus hemangioma: a fourteen year single institution experience.  

PubMed

Cavernous sinus hemangioma (CSH) is a rare extra-axial vascular neoplasm that accounts for 2% to 3% of all cavernous sinus tumors. Their location, propensity for profuse bleeding during surgery, and relationship to complex neurovascular structures are factors which present difficulty in excising these lesions. The authors describe their experience of 22 patients with CSH over 14 years at a tertiary care center. Patients were managed with microsurgical resection using a purely extradural transcavernous approach (13 patients) and with Gamma Knife radiosurgery (GKRS; Elekta AB, Stockholm, Sweden) (nine patients). Retrospective data analysis found headache and visual impairment were the most common presenting complaints, followed by facial hypesthesia and diplopia. All but one patient had complete tumor excision in the surgical series. Transient ophthalmoparesis (complete resolution in 6-8 weeks) was the most common surgical complication. In the GKRS group, marked tumor shrinkage (>50% tumor volume reduction) was achieved in two patients, slight shrinkage in five and no change in two patients, with symptom improvement in the majority of patients. To our knowledge, we describe one of the largest series of CSH managed at a single center. Although microsurgical resection using an extradural transcavernous approach is considered the treatment of choice in CSH and allows complete excision with minimal mortality and long-term morbidity, GKRS is an additional tool for treating residual symptomatic lesions or in patients with associated comorbidities making surgical resection unsuitable. PMID:24524951

Bansal, Sumit; Suri, Ashish; Singh, Manmohan; Kale, Shashank Sharad; Agarwal, Deepak; Sharma, Manish Singh; Mahapatra, Ashok Kumar; Sharma, Bhawani Shankar

2014-06-01

319

Breast cancer after radiotherapy for skin hemangioma in infancy  

SciTech Connect

Between 1920 and 1959, 9675 women were irradiated in infancy for skin hemangioma at Radiumhemmet, Stockholm. They were exposed to low to moderate doses of ionizing radiation. The mean age at first exposure was 6 months and the mean absorbed dose to the breast anlage was 0.39 Gy (range < 0.01-35.8 Gy). The breast cancer incidence was analyzed by record linkage with the Swedish Cancer Register for the period 1958-1986. Seventy-five breast cancers were found after a mean absorbed dose of 1.5 Gy in the breasts with cancer. The analyses showed a significant dose-response relationship with a linear model estimate for the excess relative risk (ERR) of 0.38 at 1 Gy (95% CI 0.09-0.85). This relationship was not modified significantly by age at exposure or by dose to the ovaries. The ERR increased significantly with time after exposure and for > 50 years after exposure the ERR at 1 Gy was 2.25 (95% CI 0.59-5.62). The fitted excess absolute risk (EAR) was 22.9 per 10{sup 4} breast-year gray. The breast absorbed dose and time after exposure were important risk determinants for breast cancer excess risk. Forty to 50 years of follow-up was necessary for the excess risk to be expressed. The study confirms previous findings that the breast anlage of female infants is sensitive to ionizing radiation. 17 refs., 6 figs.

Lundell, M.; Mattsson, A.; Hakulinen, T.; Holm, L.E. [Karolinska Hospital, Stockholm (Sweden)

1996-02-01

320

Hepatitis C  

MedlinePLUS Videos and Cool Tools

... to prevent Hepatitis C are: 1. Practice safe sex by using condoms, and knowing your partner. 2. ... that risk. Such practices include for example “rough” sex and anal sex. This document is for informational ...

321

[Hepatic granulomatosis].  

PubMed

Granulomatous hepatitis is not a uniform disease entity but a generic histopathologic diagnosis. The present review of aetiology and epidemiology of granulomas in the liver, shows that in the past tuberculosis and sarcoidosis were the most frequent but there remained a large percentage of "undiagnosis" cases; at the present drug-induced granulomatous hepatitis are frequently reported and "undiagnosed cases" are rare. Analysis of the hystological features of the most common granulomas is presented. PMID:6687632

Marcarino, C; Calcamuggi, G; Musorrofiti, A

1983-03-17

322

Mistletoe Hepatitis  

Microsoft Academic Search

A 49-year-old woman presented with nausea, general malaise, and a dull ache in the right hypochondrium. Liver biopsy showed slight inflammatory-cell infiltration, and results of liver function tests suggested hepatitis. Hepatitis B surface antigen was not detected, and a cholecystogram was normal. Two years later she presented with similar symptoms, and both illnesses were found to have occurred after ingestion

John Harvey; D. G. Colin-Jones

1981-01-01

323

Surgery of cavernous hemangioma of the optic nerve: case report and review.  

PubMed

A case of a cavernous hemangioma of the optic nerve is presented. Cavernous malformations of the cranial nerves are quite rare and have been reported to involve the third nerve, the seventh nerve in the temporal bone, the seventh and the eighth nerves in the internal auditory canal as well as the optic chiasm and optic nerve. We present a case of a patient with a cavernous hemangioma within the right optic nerve, which could be removed by microsurgery with preservation and improvement of vision. Literature on this rare location of cavernoma is reviewed. PMID:22855320

Ramina, Kristofer; Ebner, Florian H; Ernemann, Ulrike; Tatagiba, Marcos

2013-07-01

324

Multifocal intradiploic cavernous hemangioma of the skull associated with nasal osteoma  

Microsoft Academic Search

Summary.  \\u000a ?Objective: To present a 42-year-old female patient with multifocal cavernous hemangioma of the skull associated with nasal osteoma.\\u000a \\u000a \\u000a \\u000a ?Design: A case report.\\u000a \\u000a \\u000a \\u000a ?Intervention methods: X-rays, computerized tomography, magnetic resonance imaging, and histopathology were used to achieve the diagnosis of this\\u000a rare entity. The multiple cavernous hemangiomas were resected en-bloc and a curettage biopsy was obtained from the nasal osteoma.

K. Kuzeyl?; H. Usul; E. Çakir; R. Çaylan; A. Re?; S. Baykal; B. Peksoylu; U. Yazar; E. Arslan

2003-01-01

325

Deformation of the patellofemoral joint caused by synovial hemangioma: a case report.  

PubMed

A 15-year-old girl with synovial hemangioma of the knee joint presented with gait pain and occasional sudden swelling for over 7 years. Plain radiographs showed an irregular joint line and a lateral shift of the patella caused by malformation of the patellar groove. Arthroscopy was performed to resect the tumor and to release the lateral patellar retinaculum. If the synovial hemangioma exists in the patellofemoral joint during the growth period, we propose that early surgical treatment is necessary to avoid the deformation of the joint. PMID:24626098

Maeyama, Akira; Saeki, Kazuhiko; Hamasaki, Makoto; Kato, Yuki; Naito, Masatoshi

2014-07-01

326

Delta agent (Hepatitis D)  

MedlinePLUS

Hepatitis D virus ... Hepatitis D virus (HDV) is found only in people who carry the hepatitis B virus. HDV may make a ... B virus but who never had symptoms. Hepatitis D infects about 15 million people worldwide. It occurs ...

327

Gigantic Cavernous Hemangioma of the Liver Treated by Intra-Arterial Embolization with Pingyangmycin-Lipiodol Emulsion: A Multi-Center Study  

SciTech Connect

Purpose: To evaluate the therapeutic effect and safety of pingyangmycin-lipiodol emulsion (PLE) intra-arterial embolization for treating gigantic cavernous hemangioma of the liver (CHL).Methods: Three hospitals (Nanfang Hospital, Inner Mongolia Autonomous Region's Hospital and Huai He Hospital) participated in the study during 1997-2001. A total of 98 patients with CHL were embolized with PLE via the hepatic artery. The therapeutic effects including changes in tumor diameter, symptomatic improvement and occurrence of complications were evaluated for a period of 12 months after the procedure.Results: The tumor diameters decreased significantly from 9.7 {+-} 2.3 cm to 5.6 {+-} 1.6 cm 6 months after the treatment (P < 0.01), and then to 3.0 {+-} 1.2 cm at 12 months (P < 0.01). Transient impairment of liver function was found in 77 cases after embolization, 69 cases of which returned to normal in 2 weeks, and the other eight cases of which recovered 1 month later. The clinical symptoms were significantly relieved in all 53 symptomatic patients. Persistent pain in the hepatic region was found in two cases, and these two patients resorted to surgery eventually.Conclusion: Intra-arterial PLE embolization proves to be effective and safe in treating patients with CHL.

Zeng Qingle; Li Yanhao; Chen Yong [Nanfang Hospital, Department of Interventional Radiology (China); Ouyang Yong [Inner Mongolia Autonomous Region's Hospital, Department of Interventional Radiology (China); He Xiang; Zhang Heping [Huai He Hospital, Department of Interventional Radiology (China)

2004-09-15

328

Hepatitis-Associated Antigen Hepatitis  

PubMed Central

Light and electron microscopic examinations were carried out on liver tissues from 6 renal transplant recipients who developed Australia antigen-associated hepatitis, referred to in this paper as hepatitis-associated antigen (HAA) hepatitis. While under immunosuppressive therapy, the patients showed rapid progression of acute hepatitis to chronic active hepatitis and posthepatitic cirrhosis resulting in liver failure. By electron microscopy, in 5 of 6 patients, characteristic virus-like particles of 230 Å size were observed in massive numbers in the nucleus and occasionally in the cytoplasm of liver cells. No similar particles were found in liver biopsies from other patients. These particles had an appearance of nucleocapsid without an outer coat, and were believed to be the viruses in their natural infective states. The predominantly intranuclear location of the particles and the associated nuclear changes suggested that the nucleus is the primary site of virus replication. The finding of the virus-like particles is believed to be diagnostic for HAA hepatitis. While HAA is implicated in serum hepatitis, the identification of HAA with the virus-like particles of this study is still to be established. In the phagosomes, there were some particles showing an outer membrane and a tail-like structure. Both the coated and the noncoated particles were believed to be the same virus. The phagosomes also contained what appeared to be “degradated” viral material. The lysosomal activity in the infected hepatitic cells seemed to be increased. This study showed nonspecific changes of the liver cell nuclei and organelles, probably related to viral infection. The precise mechanism of cell injury remains to be elucidated. However, the result of this study has provided a reasonable basis for future investigations of HAA hepatitis. ImagesFig 10Fig 1Fig 2Fig 3Fig 4Fig 6Fig 7Fig 8Fig 9Fig 12Fig 5Fig 11Fig 13

Huang, Shao-nan

1971-01-01

329

Formation of giant planets  

NASA Astrophysics Data System (ADS)

We present calculations of giant planet formation based on extended core-accretion planet formation models taking into account disk structure and evolution and migration of the protoplanet. We show that these models lead to giant planet formation timescales compatible with disk lifetimes. Using these models, we show that we can reproduce the bulk internal structure of Jupiter and Saturn, as well as the enrichment in volatile species measured in situ by the Galileo probe (for Jupiter), and from the Earth (for Saturn). We then apply these models to the formation of the three Neptune mass planet system recently discovered by the HARPS collaboration (Lovis et al. 2006), and show that the two outer planets are likely to have accreted large amounts of water ice during their formation. Finally, the comparison with the extrasolar planets will be presented by C. Mordasini (this meeting, abstract EPSC2006-A-00672) using a Monte-Carlo approach.

Alibert, Y.; Mordasini, C.; Benz, W.

330

Paediatric giant cervicomediastinal thymolipoma.  

PubMed

We report a case of a 11-year-old boy who presented with a massive soft tissue right cervical painless and progressive lesion displacing trachea to the left and extending into the anteriosuperior mediastinum which was diagnosed to be a lipomatous mass on chest CT scan. Subsequent biopsy and total excision proved it to be a giant cervicomediastinal thymolipoma. It was successfully excised with excellent prognosis and long-term results. A giant paediatric cervicomediastinal thymolipoma is a rare, benign, mediastinal mass of thymic origin. It may remain asymptomatic despite massive size and up to 50% in some series are associated with autoimmune disease. CT scan gives fat density and encapsulated benign nature and biopsy usually establishes the diagnosis. Preoperative tissue diagnosis is important as now the availability of thoracoscopic option is best suited to reduce morbidity. Treatment of choice is total excision using open surgical, minimal invasive techniques or robotic surgery and the prognosis is excellent. PMID:24849642

Patel, Ramnik V; Evans, Kathryn; Sau, Indranil; Huddart, Simon

2014-01-01

331

Giant Prostatic Hyperplasia  

PubMed Central

A giant prostatic hyperplasia (GPH) weighing more than 700 g is a rare entity. It is believed that only eight such cases have been previously reported in the medical literature. This case report concerns a patient with a GPH weighing 740 g which was successfully removed by suprapubic prostatectomy. To our knowledge, this is the fourth largest benign prostatic enlargement ever reported in the literature.

Maliakal, Joseph; Mousa, Emad E.; Menon, Varna

2014-01-01

332

Hot giant loop holography  

SciTech Connect

We argue that there is a phase transition in the expectation value of the Polyakov loop operator in the large N limit of the high temperature deconfined phase of N=4 Yang-Mills theory on a spatial S{sup 3}. It occurs for the large completely symmetric representation of the SU(N) symmetry group. We speculate that this transition is reflected in the D-branes which are the string theory duals of giant loops.

Grignani, Gianluca [Dipartimento di Fisica, Universita di Perugia, INFN Sezione di Perugia, Via A. Pascoli, 06123 Perugia (Italy); Karczmarek, Joanna L.; Semenoff, Gordon W. [Department of Physics and Astronomy, University of British Columbia, Vancouver, British Columbia V6T 1Z1 (Canada)

2010-07-15

333

Giant paravertebral myxoma  

Microsoft Academic Search

The study design includes case report and clinical discussion. The objective was to describe a rare case of a giant intramuscular\\u000a myxoma (IMM) presenting as a mass in the paravertebral muscles. Myxoma is a rare benign soft tissue tumour of mesenchymal\\u000a origin. Although intramuscular presentation is common, they are rare in the paravertebral muscles and are characteristically\\u000a <5 cm in length.

A. Rashid; H. B. Abdul-Jabar; S. Karmani; K. Rezajooi; A. T. H. Casey

2011-01-01

334

Giant cell arteritis  

PubMed Central

Giant cell arteritis (GCA), temporal arteritis or Horton's arteritis, is a systemic vasculitis which involves large and medium sized vessels, especially the extracranial branches of the carotid arteries, in persons usually older than 50 years. Permanent visual loss, ischaemic strokes, and thoracic and abdominal aortic aneurysms are feared complications of GCA. The treatment consists of high dose steroids. Mortality, with a correct treatment, in patients with GCA seems to be similar that of controls.

Calvo-Romero, J

2003-01-01

335

Voyager: Giant Kelp  

NSDL National Science Digital Library

The Birch Aquarium at Scripps Institution of Oceanography offers this Web site as part of the Aquarium's online educational series, Voyager Science. Geared toward younger kids, this site introduces the kelp forest and related concepts with great photos, informative descriptions, and a few interactive activities. Giant Kelp focuses on the kelp plant itself, including the many (and often surprising) commercial uses of kelp products. Simple at-home experiments and online activities are also included.

Criqui, Nan

336

Hepatitis B Frequently Asked Questions  

MedlinePLUS

... to... Añadir en... Favorites Delicious Digg Google Bookmarks Hepatitis B FAQs for the Public Index of Questions ± Overview ... C. What is the difference between Hepatitis A, Hepatitis B, and Hepatitis C? Hepatitis A , Hepatitis B , and ...

337

Giant Olfactory Meningiomas  

PubMed Central

Olfactory groove meningiomas may attain surprisingly large size. The subfrontal approach is currently the route preferred by most neurosurgeons for their excision. The pterional-transsylvian route represents an alternate exposure for microsurgery of frontobasal tumors. Although this approach has been already described for olfactory meningiomas, tumors of giant size were not specifically addressed in the literature. We report the application of the pterional-transsylvian approach in six patients with giant olfactory meningiomas. This series is unique because it includes only patients with tumors exceeding 6 cm in diameter with bilateral symmetrical development. A radical removal was achieved in all patients and all of them made a full recovery. To investigate the relevance of the pterional-transsylvian approach for minimizing surgical morbidity, a magnetic resonance imaging protocol was designed to characterize even subtle postoperative frontal lobe structural changes. These changes, limited to the frontal lobe ipsilateral to exposure and localized in specific anatomical domains of the prefrontal area, included cystic degenerative alterations, parenchymal gliosis, and associated persistent white matter edema. Results from the present series strengthen the usefulness of the pterional-transsylvian approach as a safe surgical route for lesions affecting the anterior skull base, even with huge bilateral symmetrical expansion, such as giant olfactory meningiomas. ImagesFigure 1Figure 2Figure 3p26-bFigure 4p27-bFigure 5Figure 6Figure 7

d'Avella, Domenico; Salpietro, Francesco M.; Alafaci, Cetty; Tomasello, Francesco

1999-01-01

338

Solitary hepatic lymphangioma: report of a case.  

PubMed

A 52-year-old woman presented with upper abdominal pain. Abdominal ultrasonography showed a 4-cm well-defined mass containing solid and cystic components in segment IV of the liver, and contrast-enhanced T1-weighted magnetic resonance imaging revealed heterogeneous enhancement within the tumor, indicating a solid or fibrous component. There were no cystic lesions in any other organs. A partial hepatectomy was performed, based on a preoperative diagnosis of sclerosing hemangioma and biliary cystadenoma or cystadenocarcinoma. Pathologically, the tumor appeared to be a multilocular and cystic lesion lined by attenuated endothelial- like cells with no atypia. Immunohistochemistry demonstrated the endothelial-like cells to be positive for the lymphatic-specific markers D2-40, LYVE-1, and Prox-1, which proved helpful for confirming the diagnosis as solitary hepatic lymphangioma. This case is presented with details of the pathologic and radiologic findings, because solitary hepatic lymphangioma is an extremely rare tumor and no previous reports have provided details of the immunohistochemical characteristics. PMID:20740355

Matsumoto, Takuya; Ojima, Hidenori; Akishima-Fukasawa, Yuri; Hiraoka, Nobuyoshi; Onaya, Hiroaki; Shimada, Kazuaki; Mizuguchi, Yasunori; Sakurai, Shintaro; Ishii, Toshiharu; Kosuge, Tomoo; Kanai, Yae

2010-09-01

339

Identification of serum regression signs in infantile hemangioma.  

PubMed

Vessel proliferation underlies a number of serious pathological conditions. Infantile Hemangioma (IH) is a low-aggressive vascular tumor, interesting as an in vivo model of spontaneous tumor regression. Identifying mechanisms underlying IH spontaneous regression may then help to elucidate vessel-growth control, strongly deregulated in other serious conditions such as sarcoma, melanoma, diabetic retinopathy. The present study was aimed at identifying early regression indicators within hematological parameters. Thirty-four blood samples were collected from IH diagnosed babies (20-months median age), spontaneously regressing with age. Nineteen serum standard blood-tests were carried out using diagnostic reagents; in addition, serum-expression of 27 cytokine/chemokines was measured. Samples were divided in three age-groups, namely ? 12, 13 to 24 and >24 months-age, respectively. Red-cells count, Hemoglobin, Hematocrit, Neutrophils, Lymphocytes, MCP-1 and MIP-1beta were significantly different in the three age-groups, according to one-way ANOVA analysis. The same parameters showed a significant Pearson-correlation with age, supporting the direct link of age with IH-regression. ROC analysis showed that red-cells count, Hemoglobin, Hematocrit, MCP-1 and MIP-1beta levels significantly discriminate IH in the proliferating-phase from IH in the regressing-phase. Such data indicate for the first time that standard hematological tests and cytokine serum-expression values may effectively discriminate proliferating- from regressing-IH, unrevealing early regression signs, and demonstrate that standard blood-tests may have novel unsuspected diagnostic/prognostic relevance in altered vessel-growth conditions. PMID:24599340

D'Arcangelo, Daniela; Nicodemi, Ezio M; Rossi, Stefania; Giampietri, Claudia; Facchiano, Francesco; Facchiano, Antonio

2014-01-01

340

How Airway Venous Malformations Differ From Airway Infantile Hemangiomas  

PubMed Central

Objective To compare airway infantile hemangiomas (IHs) and venous malformations (VMs) clinically, radiographically, endoscopically, and histologically. Design Retrospective cohort study. Setting Tertiary care pediatric hospital. Patients The study included patients seen in the Vascular Anomaly Clinic, Seattle Children’s Hospital, Seattle, Washington, between 2001 and 2008. Methods All patients with airway vascular anomalies were identified by searching the Vascular Anomaly Quality Improvement Database and hospital discharge data. The data, which were analyzed with descriptive statistics and the Fisher exact test, included presenting age, sex, presenting signs, lesion site, and radiographic, endoscopic, and histologic findings.. Results Seventeen patients with airway lesions were identified, 6 with VMs and 11 with IHs. Patients with VMs presented at a mean (SD) age of 11.3 (13.7) months (age range, 3–39 months), while those with IHs presented at 3 (1.8) months of age (age range, 1–6 months) (P =.03). The patients with IHs were predominantly female (9 of 11 [81%]), while no sex difference was noted among the patients with VMs (3 of 6 [50%]). All patients with IHs presented with stridor and cutaneous lesions, whereas patients with VMs more often presented with hemoptysis or dysphagia (P = .001). Computed tomographic angiograms demonstrated enhancing endolaryngeal lesions in all IHs, while VMs enhanced poorly. Endoscopically, IHs were transglottic, while VMs were postcricoid or epiglottic (P <.001). Histologically, immunostained lesions showed submucosal lobules of capillaries lined by GLUT-1 (glucose transporter isoform 1)–positive endothelium in IHs, whereas VMs consisted of loosely organized venous channels that lacked GLUT-1 staining. Conclusion Patients with airway IHs and VMs differ in presenting age and signs, sex, airway lesion location, enhancement on computed tomographic angiograms, and histologic appearance.

Parhizkar, Nooshin; Manning, Scott C.; Inglis, Andrew F.; Finn, Laura S.; Chen, Eunice Y.; Perkins, Jonathan A.

2013-01-01

341

Giant European dinosaur found in Spain  

NSDL National Science Digital Library

Fossils of a giant Sauropod, found in Spain, reveal that Europe was home to giant dinosaurs in the Late Jurassic period -- about 150 million years ago. Giant dinosaurs have previously been found mainly in the New World and Africa.

American Association for the Advancement of Science (AAAS;)

2006-12-21

342

Integrated imaging of hepatic tumors in childhood. Part II. Benign lesions (congenital, reparative, and inflammatory)  

SciTech Connect

The authors have encountered benign liver masses as frequently as malignant lesions in children with hepatomegaly. Lesions studied included abscesses, cavernous hemangioma/hemangioendothelioma, adenoma of glycogen storage disease, choledochal cysts, focal nodular hyperplasia, cystic hepatoblastoma, and hamartoma. An intergrated imaging protocol involving ultrasound, computed tomography, and scintigraphy proved to be more helpful than any one modality in establishing the benign or malignant nature of a hepatic neoplasm and the type of tumor, which is of particular importance when surgical exploration and/or biopsy is contraindicated.

Miller, J.H.; Greenspan, B.S.

1985-01-01

343

Hepatic hemangioendothelioma of infancy with congestive cardiac failure--report of a case.  

PubMed

A case of infantile hemangioendothelioma of the liver is reported in a 18 day-old male neonate. The neonate presented with CHF. He had hepatomegaly, but lacked the third component of the classical triad i.e. cutaneous hemangiomas. The S.A.F.P levels were raised to 920 ng/ml, though rise is rare in infantile hemangioendothelioma and led to the clinical diagnosis of hepatoblastoma. A left hepatic resection was performed, the histology showed a type I pattern of the tumor. This is known to be associated with a good prognosis. The baby is well post resection for a follow up period of six months. PMID:8772823

Pethe, V V; Kalgutkar, A D; Mondkar, J; Oak, S N; Deodhar, K P; Deshmukh, S S

1995-12-01

344

Superficial hemosiderotic lymphovascular malformation (hobnail hemangioma): a report of six cases.  

PubMed

Hobnail hemangioma (HH), initially termed targetoid hemosiderotic hemangioma, is a rare, often solitary lesion classically characterized by a central brown or violaceous papulonodule surrounded at times by an ecchymotic halo. This lesion is typically found on the trunk or limbs of children or young to middle-aged adults. Numerous case reports have found HHs to have a reproducible histologic appearance. Although the exact histogenesis of these lesions is unknown, multiple recent immunohistochemical studies suggest a lymphatic origin of these lesions. We present six cases of children with HHs with classic histology but with variability in their clinical appearance. Because the clinical presence of a targetoid halo is inconsistent and the hobnail phenomenon is not specific, we favor the designation of superficial hemosiderotic lymphovascular malformation instead of HH or targetoid hemosiderotic hemangioma as a more unifying term for this rare clinical entity. By eliminating confounding terminologies (in this case, incorporation of "hemangioma" in the name of this entity), we also hope to encourage a swifter change in practice to move away from erroneous diagnostic considerations. PMID:24601986

Joyce, Joel C; Keith, Phillip J; Szabo, Sara; Holland, Kristen E

2014-05-01

345

[Management of orbital cavernous hemangioma - evaluation of surgical approaches: report of 43 cases].  

PubMed

Cavernous hemangioma is the most frequent benign orbital tumor in adults. The purpose of this study was to examine its clinical features, to define surgical indications, and to determine the roles of the various surgical approaches praticed in ophthalmology: transconjunctival (increasingly utilized), anterior transcutaneous, and lateral orbitotomy. The records of all patients treated for orbital cavernous hemangioma (OCH) since 2004 at the Fondation Rothschild (Paris, France) were retrospectively reviewed. Forty-three patients were treated for orbital cavernous hemangioma. Fifty-eight percent were women, mean age 50.2; 79 % of the tumors were intraconal. Among those patients, 36 underwent surgical removal, 5 were followed periodically, and 2 were lost to follow-up. The main surgical indications were: optic nerve compression (26 patients), proptosis (24 patients) and diplopia (3 patients). Transconjunctival, anterior transcutaneous and Kronlein approaches were used in 16, 12 and 4 patients respectively. Four patients had intrapalpebral hemangiomas easily reached transcutaneously. Two patients demonstrated transient partial 3rd nerve palsy (one with the lateral orbitotomy approach and one with the transconjunctival approach), one patient with the lateral orbitotomy approach developed a palsy of the superior branch of the 3rd nerve, and one patient with the transcutaneous anterior approach developed mydriasis. Surgical excision of OCH's is required in the presence of clinical complications. The transconjunctival approach is a safe technique which can lead to complete resection of the tumor in most cases. PMID:24119454

Aymard, P-A; Langlois, B; Putterman, M; Jacomet, P-V; Morax, S; Galatoire, O

2013-12-01

346

Detection of an ileal cavernous hemangioma by technetium-99m red blood cell imaging  

SciTech Connect

Patients with arteriovenous malformations of the bowel may have multiple symptoms secondary to chronic blood loss. A case of ileal cavernous hemangioma detected by Tc-99m labeled red blood cell imaging in the absence of active gastrointestinal bleeding is presented.

Holloway, H.; Johnson, J.; Sandler, M.

1988-01-01

347

Sebaceous Gland Carcinoma of the Eyelid. Following radiation Therapy for Cavernous Hemangioma of the Face.  

National Technical Information Service (NTIS)

A 37-year-old woman had received multiple radiation treatments between the ages of 6 months and 15 years for an extensive cavernous hemangioma of the left side of the face. At age 27, a biopsy specimen disclosed squamous cell carcinoma arising in chronic ...

D. A. Schlernitzauer R. L. Font

1976-01-01

348

Cavernous hemangiomas of the liver: Are there any indications for resection  

Microsoft Academic Search

A total of 163 patients with cavernous hemangiomas of the liver were managed at Paul Brousse Hospital between 1970 and 1992. The tumor was smaller than 4 cm in 54 patients and larger than 10 cm in 38 patients. The diagnostic sensitivities of the imaging procedures were as follows: ultrasonography 61%; angio-computed tomography scanning 77%; angiography 85%; magnetic resonance imaging

Olivier Farges; Salam Daradkeh; Henri Bismuth

1995-01-01

349

Asymptomatic right atrial cavernous hemangioma: a case report and review of the literature  

Microsoft Academic Search

A case of asymptomatic right atrial cavernous hemangioma in a 50-year-old man is reported. With right atriotomy under total cardiopulmonary bypass, the right atrial mass was identified as arising from the noncoronary Sinus of Valsalva. The mass was successfully resected with the Sinus of Valsalva closed primarily. The patient is alive and well 9 months following the operation. The incidental

John E. Thomas; Alec T. Eror; Minh Kenney; Joseph Caravalho

2004-01-01

350

Bone Erosion Caused by Sinonasal Cavernous Hemangioma: CT Findings in Two Patients  

Microsoft Academic Search

Summary: We report two cases of cavernous hemangioma orig- inating in the sinonasal cavity. Although CT showed some en- hancing areas within both tumors, the substantial bone destruc- tion caused by these tumors made it difficult to differentiate them from the more common malignant epithelial tumors. An- giography was performed in one patient and showed character- istic pooling of contrast

Hyung-Jin Kim; Jung Hee Kim; Jae Hyoung Kim; Eui Gee Hwang

351

Long term follow-up of intralesional laser photocoagulation (ILP) for hemangioma patients  

PubMed Central

Background and Objectives: Hemangiomas remain a challenge for patients and plastic surgeons. Promising results have been reported using intralesional photocoagulation (ILP) for treatment. The objective of our study is to review the long term results of a large series of hemangiomas in patients treated by ILP. Materials (Subjects) and Methods: A retrospective review of 684 hemangiomas in patients were treated by ILP with an Nd:YAG (neodymium-yttrium-aluminium-garnet) (1064 nm) laser over a period of 10 years (January 1996–January 2005). Patients’ ages ranged from one month to 11 years 5 months (mean, 1 year 10 months). The patient group consisted of 474 females and 210 males. Results: Patients were treated with an Nd:YAG laser delivered through a 600 m optical fiber. Laser power was set at 7 to 15 watts (W) and delivered with pulse duration of 7 to 15 seconds (s). The results showed 603 (88.6%) patients had more than 50% reduction of the volume in hemangiomas at 3 months after one treatment; and 663 (96.9%) patients had more than 50% reduction of the volume at 3 months after two treatments. Patients who had continuous ILP achieved excellent results. Conclusions: Postoperative complications have been related to photocoagulation that has been delivered too extensively or superficially, with resultant ulceration, infection, bleeding, and scarring. These complications can be avoided if this potential for harm is kept in mind.

Chang, Cheng-Jen

2011-01-01

352

Orbital cavernous hemangioma in an infant with intracranial lesions: a case report  

Microsoft Academic Search

INTRODUCTION: Cavernous hemangiomas of the orbit are benign vascular malformations, commonly encountered in adults. Although they are infrequent in pediatric population their diagnosis and course are of a great significance, mainly because they can cause visual disturbances such as amblyopia that can ensue, and secondarily due to their cosmetic and psychological effect. Special attention is required in follow up and

Eleni Evagelidou; Elena Tsanou; Ioannis Asproudis; Spiridon Gorezis; Miltiadis Aspiotis; Dimitrios Peschos; Antigoni Siamopoulou

2009-01-01

353

Intra-articular hemangioma of the knee with meniscal and bony attachment  

Microsoft Academic Search

A hemangioma in the knee joint of a 37-year-old woman was diagnosed by magnetic resonance imaging. The case presented with pain and a tender localized swelling lateral to the patellar tendon. Arthroscopy verified the diagnosis but did not allow visualization of the full extent of the tumor. After arthroscopic subtotal excision of the associated hypertrophic medial plica, a miniarthrotomy was

Halit Pinar; Murat Bozkurt; Lütfü Baktiro?lu; Osman Karao?lan

1997-01-01

354

Spastic diplegia as a complication of interferon Alfa-2a treatment of hemangiomas of infancy  

Microsoft Academic Search

We report the development of spastic diplegia in infants during the course of interferon Alfa-2a (IFN) therapy for potentially life-endangering hemangiomas. Five infants who displayed diplegia were selected from a group of 26 infants treated with IFN. Diplegia persisted in three infants, and in the remaining two significant recovery occurred after IFN was discontinued. Magnetic resonance imaging showed no significant

Charles F. Barlow; Cedric J. Priebe; John B. Mulliken; Patrick D. Barnes; Dorothy Mac Donald; Judah Folkman; R. Alan B. Ezekowitz

1998-01-01

355

Rapid regrowth of a capillary hemangioma of the thoracic spinal cord.  

PubMed

A 48-year-old man presented with a 2-week history of progressive gait disturbance. Neurological examinations showed mild weakness in his lower extremities and depreciation of deep sensation. Magnetic resonance (MR) imaging showed an intradural extramedullary enhanced lesion at the levels of the T10 and T11 vertebrae. Laminectomy of the T10 and T11 vertebrae was performed, and the vascular tumor on the spinal cord surface was completely resected. Histological analysis indicated that the lesion was a capillary hemangioma with an elevated proliferative index. Postoperatively, the patient showed rapid motor and sensory improvement. However, 6 months after the operation, MR imaging showed regrowth of the tumor although the clinical symptoms of the patient had not deteriorated. The patient has shown no tumor regrowth 9 years after the second operation. Capillary hemangiomas in the skin and soft tissues are often associated with high proliferative activity, and recurrence/regrowth is not infrequent. On the other hand, recurrence/regrowth of capillary hemangioma in the neuraxis after tumor resection has rarely been observed, even in cases of incomplete resection. The present case illustrates the treatment of recurrent capillary hemangioma of the spinal cord. PMID:23006883

Kaneko, Yoichi; Yamabe, Kazutoshi; Abe, Masamitsu

2012-01-01

356

Mistletoe hepatitis.  

PubMed Central

A 49-year-old woman presented with nausea, general malaise, and a dull ache in the right hypochondrium. Liver biopsy showed slight inflammatory-cell infiltration, and results of liver function tests suggested hepatitis. Hepatitis B surface antigen was not detected, and a cholecystogram was normal. Two years later she presented with similar symptoms, and both illnesses were found to have occurred after ingestion of a herbal remedy containing kelp, motherwort, skullcap, and mistletoe. A challenge test established this to be the cause of the illness. Mistletoe is the only constituent of the tablets known to contain any potential toxin and thus was probably the cause of the illness. Mistletoe is widely used in herbal remedies, whose ingestion may therefore cause hepatitis. Images FIG 1 FIG 2

Harvey, J; Colin-Jones, D G

1981-01-01

357

Minimal invasive method to treat hemangiomas of the oral cavity with a CO2 laser  

NASA Astrophysics Data System (ADS)

During the last six years we have developed a new CO2 laser technique for the treatment of symptomatic oral cavity hemangioma. Our new technique, named 'laser encircling technique', has especially succeeded during hemangioma buccal maxillary surgeries. The treatment consisted in the application of a line of points of CO2 laser circling the lesion. Depending on the position and size of the lesion, we used from 0.4 to 4.0 Joules/mm2 laser energy density per pulse, causing reduction in the size of the lesion throughout the sclerosis of nutritional vessels which led to reduction in size, volume and color of the hemangiomas with no significant bleeding or inflammatory reaction. In this work forty male and female patients, twelve to fifty years old, presenting medium to small size hemangiomas situated in different sites of the oral cavity such as the tongue, mouth vestibule, pharynx, tonsil area and lips were treated by the procedure described above. The number of laser applications was defined by the peculiarities of each case, varying form 3 to 6 sessions at 4 week intervals, always under local or topic anesthesia. The patients complained about minimal posit operative discomfort and had good cicatrix evolution. The good results achieved by this technique lead to the conclusion that CO2 laser for these types of hemangioma is an efficient and very secure method of treatment. An important aspect of our technique is the fact that using relatively low laser power we do not perform real surgery but a less aggressive alternative of treatment.

Nicola, Ester M.; Nicola, Jorge H.; Gusmao, Reinaldo J.; Coutinho, Adriana A.; Cassitas, Nilceu

1997-05-01

358

Diagnostics of hemangioma by the methods of correlation and fractal analysis of laser microscopic images of blood plasma  

NASA Astrophysics Data System (ADS)

For the first time the complex correlation and fractal analysis was used for the investigation of microscopic images of both tissue images and hemangioma liquids. It was proposed a physical model of description of phase distributions formation of coherent radiation, which was transformed by optical anisotropic biological structures. The phase maps of laser radiation in the boundary diffraction zone were used as the main information parameter. The results of investigating the interrelation between the values of correlation (correlation area, asymmetry coefficient and autocorrelation function excess) and fractal (dispersion of logarithmic dependencies of power spectra) parameters are presented. They characterize the coordinate distributions of phase shifts in the points of laser images of histological sections of hemangioma, hemangioma blood smears and blood plasma with vascular system pathologies. The diagnostic criteria of hemangioma nascency are determined.

Boychuk, T. M.; Bodnar, B. M.; Vatamanesku, L. I.

2011-09-01

359

Giant mesenteric cyst  

PubMed Central

Mesenteric cysts are uncommon benign abdominal lesions with no classical clinical features. The preoperative diagnosis requires the common imaging modalities but the final diagnosis is established only during surgery or histological analysis. The treatment of choice is complete surgical excision. We report an 18-year-old female with a non-specific abdominal pain and discomfort since 3 weeks. Her CT scan showed a huge cystic swelling, which necessitated surgical exploration. Preoperatively, a giant cyst was encountered with displacement of bowel loops. The cyst was completely removed and histology report confirmed mesenteric cyst without evidence of malignancy.

Guraya, Salman Yousuf; Salman, Shaista; Almaramhy, Hamdi H.

2011-01-01

360

PHACE association with intracranial, oropharyngeal hemangiomas, and an atypical patent ductus arteriosus arising from the tortuous left subclavian artery in a premature infant  

PubMed Central

PHACE association is a rare neurocutaneous condition in which facial hemangiomas associate with a spectrum of posterior fossa malformations, arterial cerebrovascular anomalies, cardiovascular anomalies, and eye anomalies. We reported a case of PHACE association in a premature infant showing facial, intracranial, and oropharyngeal hemangiomas with evidence of the Dandy-Walker variant and complicated cardiovascular anomalies, including a right-sided aortic arch and an atypical patent ductus arteriosus arising from a tortuous left subclavian artery. To our knowledge, intracranial hemangiomas are rare in PHACE association, and a concomitant oropharyngeal hemangioma has not been previously reported in the PHACE association literature. In infants presenting with large, plaque-like facial hemangiomas, it is important to conduct active cardiovascular and neurological evaluations. Special attention should be given to the laryngoscopic examination to search for additional hemangiomas in the airway.

Choi, Jang Hwan; Lee, Jung Ha; Kim, Hee Sup

2012-01-01

361

Neonatale Hepatitis  

Microsoft Academic Search

During the period 1961–1966 12 children (6 males, 6 females) underwent thorough clinical investigations because of neonatal hepatitis. The onset of jaundice varied from the first day of life to the third month; jaundice lasted from between 30 to 150 days. Laboratory tests — including the determination of several serum enzyme activities — did not make possible a definite differentiation

Wulff-Dietrich Beseler; Hans Werner Rotthauwe

1971-01-01

362

Unique case of giant adult paratesticular spindle cell rhabdomyosarcoma.  

PubMed

A 50-year-old unmarried rural man was referred for a giant painless scrotal lump which had developed over a period of about six years. At the admission physical examination disclosed a large swelling scrotum and palpable left supraclavicular lymph nodes. Blood counts, renal and hepatic function tests, lactate dehydrogenase, beta-HCG, and alpha-fetoprotein were normal. Computed tomographic scan of thorax and abdomen revealed supraclavicular, mediastinal, and retroperitoneal adenopathies. The patient underwent right-sided radical orchiectomy. The final pathological diagnosis was paratesticular spindle cell rhabdomyosarcoma. Unfortunately, few days after surgery, patient presented a clinical and laboratory picture of disseminated intravascular coagulation followed by exitus. PMID:19036416

Silvestris, Nicola; Zito, Francesco Alfredo; Resta, Leonardo; Popescu, Ondina; Rossi, Roberta; Montemurro, Severino; Colucci, Giuseppe

2009-03-01

363

Fine-needle aspiration diagnosis of sclerosing hemangioma (pneumocytoma): report of a case and review of the literature.  

PubMed

Sclerosing hemangioma (pneumocytoma) is a rare benign lung tumor with uncertain histogenesis but characteristic histology. Reports of the cytopathology of this tumor are even rarer with only a handful of cases in the literature--many of these incorrectly diagnosed by cytology initially. Herein, we describe a case of sclerosing hemangioma diagnosed prima facie by fine-needle aspiration cytology. A cell block preparation with accompanying immunohistochemistry was instrumental in making the diagnosis. A review of the literature is also presented. PMID:22645055

Dettrick, Andrew; Meikle, Anne; Fong, Kwun M

2014-03-01

364

Epithelioid hemangioma of the internal carotid artery: A case report supporting the reactive pathogenesis hypothesis of this vascular tumor.  

PubMed

The pathogenesis of epithelioid hemangioma is intriguing and has remained a controversial topic in the medical literature. Whether its etiology follows a neoplastic or reactive process is unclear, but a history of traumatic insult to the involved region is common. We report a case of epithelioid hemangioma of the internal carotid artery in a child who had undergone cannulization of the internal jugular vein as an infant to receive extracorporeal membrane oxygenation. PMID:24837865

Abrahim, Mena J; Gregory, Naomi D; Chennupati, Sri Kiran

2014-07-01

365

Gas Giants Form Quickly  

NASA Technical Reports Server (NTRS)

This is an artist's concept of a hypothetical 10-million-year-old star system. The bright blur at the center is a star much like our sun. The other orb in the image is a gas-giant planet like Jupiter. Wisps of white throughout the image represent traces of gas.

Astronomers using NASA's Spitzer Space Telescope have found evidence showing that gas-giant planets either form within the first 10 million years of a sun-like star's life, or not at all. The lifespan for sun-like stars is about 10 billion years.

The scientists came to this conclusion after searching for traces of gas around 15 different sun-like stars, most with ages ranging from 3 million to 30 million years. With the help of Spitzer's Infrared Spectrometer instrument, they were able to search for relatively warm gas in the inner regions of these star systems, an area comparable to the zone between Earth and Jupiter in our own solar system. They also used ground-based radio telescopes to search for cooler gas in the outer regions of these systems, an area comparable to the zone around Saturn and beyond.

2007-01-01

366

Giant papillary conjunctivitis.  

PubMed Central

Giant papillary conjunctivitis is a syndrome found frequently as a complication of contact lenses. Many variables can affect the onset and severity of the presenting signs and symptoms. Rigid gas permeable contact lenses appear to result in less severe signs and symptoms, with a longer time before the development of giant papillary conjunctivitis. Nonionic, low-water-content soft contact lenses tend to produce less severe signs and symptoms than ionic, low-water-content soft contact lenses. Enzymatic treatment appears to lessen the severity of signs and symptoms. The association of an allergy appears to play a role in the onset of the severity of the signs and symptoms but does not appear to affect the final ability of the individual to wear contact lenses. Using multiple treatment options, such as changing the polymer to a glyceryl methyl methacrylate or a rigid lens, or utilizing a soft lens on a frequent-replacement basis, can result in a success rate of over 90%. In individuals who still have a return of symptoms, the use of topical mast cell stabilizers or a nonsteroidal anti-inflammatory drug as an adjunctive therapy offers the added possibility of keeping these patients in contact lenses. Images FIGURE 1 FIGURE 2 FIGURE 3 FIGURE 4 FIGURE 5 FIGURE 6 FIGURE 7 FIGURE 11 A FIGURE 11 B FIGURE 11 C FIGURE 11 D

Donshik, P C

1994-01-01

367

Are bilateral cavernous hemangiomas of the orbit rare entities? The role of MRI in a retrospective study.  

PubMed

Cavernous hemangioma is a benign orbital extraocular vascular lesion consisting of large dilated venous channels with fibrous, well-delineated capsule and hemosiderin deposition. Cavernous hemangioma is considered to be almost always unilateral and bilateral cases have been rarely described. The aim of our study is to evaluate imaging characteristics of cavernous hemangioma and evaluate the prevalence of bilateral cases. We studied 14 patients with cavernous hemangioma of the orbit with surgical confirmation. MRI was performed on a 1.5-T unit before and after contrast agent administration. Each MR examination had been retrospectively evaluated in order to define signal patterns, dimensions, location and other main imaging characteristics. In 3 out of the 14 cases studied (21.4%) bilateral cavernous hemangiomas were found. Thirteen masses appeared isointense on T1, two were hypointense, and two heterogeneous. On T2, 12 were hyperintense, 3 were heterogeneous, 1 isointense, and 1 hypointense. Contrast enhancement was inhomogeneous in 5, homogeneous and intense in 12 cases. The size ranged from 3mm up to 21 mm (average 14.57). In four patients also CT scan without contrast administration of the orbits was performed. Bilateral cavernous hemangioma appears to be more frequent than as predicted by the literature. In our opinion the main reason of this incongruence is related to technological advances. Our results could also be related to carelessness of radiologists to inspect the other orbit for possible concomitant lesions, and thus invites to major attention in exploring both orbits for eventual bilateral lesions. PMID:17644295

Paonessa, Amalia; Limbucci, Nicola; Gallucci, Massimo

2008-05-01

368

Phase II Study to Assess the Efficacy of Hypofractionated Stereotactic Radiotherapy in Patients With Large Cavernous Sinus Hemangiomas  

SciTech Connect

Purpose: Cavernous sinus hemangioma is a rare vascular tumor. The direct microsurgical approach usually results in massive hemorrhage. Although radiosurgery plays an important role in managing cavernous sinus hemangiomas as a treatment alternative to microsurgery, the potential for increased toxicity with single-session treatment of large tumors is a concern. The purpose of this study was to assess the efficacy of hypofractionated stereotactic radiotherapy in patients with large cavernous sinus hemangiomas. Methods: Fourteen patients with large (volume >20 cm{sup 3}) cavernous sinus hemangiomas were enrolled in a prospective Phase II study between December 2007 and December 2010. The hypofractionated stereotactic radiotherapy dose was 21 Gy delivered in 3 fractions. Results: After a mean follow-up of 15 months (range, 6-36 months), the magnetic resonance images showed a mean of 77% tumor volume reduction (range, 44-99%). Among the 6 patients with cranial nerve impairments before hypofractionated stereotactic radiotherapy, 1 achieved symptomatic complete resolution and 5 had improvement. No radiotherapy-related complications were observed during follow-up. Conclusion: Our current experience, though preliminary, substantiates the role of hypofractionated stereotactic radiotherapy for large cavernous sinus hemangiomas. Although a longer and more extensive follow-up is needed, hypofractionated stereotactic radiotherapy of 21 Gy delivered in 3 fractions is effective in reducing the tumor volume without causing any new deficits and can be considered as a treatment modality for large cavernous sinus hemangiomas.

Wang Xin; Liu Xiaoxia; Mei Guanghai; Dai Jiazhong; Pan Li [Departments of Neurosurgery and CyberKnife, Huashan Hospital, Fudan University, Shanghai (China); Wang Enmin, E-mail: wangem@fudan.edu.cn [Departments of Neurosurgery and CyberKnife, Huashan Hospital, Fudan University, Shanghai (China)

2012-06-01

369

Ptotic Gall Bladder with Hepatic Masses: A Case Report  

PubMed Central

Gall bladder (GB) may be found in a variety of abnormal positions. Most of them are due to arrested development of embryonic growth at different stages. A 63-year-old female patient was admitted to our radiology unit for magnetic resonance imaging (MRI) of the liver for the lesions identified in abdominal ultrasonography (US) and computed tomography (CT). MRI showed that there was a lobulated heterogenous mass in the left lobe of the liver and a smaller one in the right lobe of the liver with the same appearance. The inferior pole of the liver was located in the pelvic space, and the GB, which contained sludges and stones, was lying down to the upper pelvic space. Hepatic masses were considered to be hemangiomas, and GB was diagnosed as ptotic GB with luminal sludge and stones. In this case, especially, MR imaging helped the surgeon to plan a proper approach to the GB in abnormal localization.

Aydin, Hasan; Aydin, Z. Banu; Hekimoglu, Baki; Gormeli, Ayse

2013-01-01

370

What Is Hepatitis?  

MedlinePLUS

... and effective vaccines are available to prevent HAV. Hepatitis B virus (HBV) is transmitted through exposure to infective ... serious disease and worse outcome. Safe and effective hepatitis B vaccines provide protection from HDV infection. Hepatitis E ...

371

Hepatitis B virus (image)  

MedlinePLUS

Hepatitis B is also known as serum hepatitis and is spread through blood and sexual contact. It is ... population. This photograph is an electronmicroscopic image of hepatitis B virus particles. (Image courtesy of the Centers for ...

372

Giant vesicles: preparations and applications.  

PubMed

There is considerable interest in preparing cell-sized giant unilamellar vesicles from natural or nonnatural amphiphiles because a giant vesicle membrane resembles the self-closed lipid matrix of the plasma membrane of all biological cells. Currently, giant vesicles are applied to investigate certain aspects of biomembranes. Examples include lateral lipid heterogeneities, membrane budding and fission, activities of reconstituted membrane proteins, or membrane permeabilization caused by added chemical compounds. One of the challenging applications of giant vesicles include gene expressions inside the vesicles with the ultimate goal of constructing a dynamic artificial cell-like system that is endowed with all those essential features of living cells that distinguish them from the nonliving form of matter. Although this goal still seems to be far away and currently difficult to reach, it is expected that progress in this and other fields of giant vesicle research strongly depend on whether reliable methods for the reproducible preparation of giant vesicles are available. The key concepts of currently known methods for preparing giant unilamellar vesicles are summarized, and advantages and disadvantages of the main methods are compared and critically discussed. PMID:20336703

Walde, Peter; Cosentino, Katia; Engel, Helen; Stano, Pasquale

2010-05-01

373

Diabetes and Hepatitis B Vaccination  

MedlinePLUS

Diabetes and Hepatitis B Vaccination Information for Diabetes Educators What is hepatitis B? Hepatitis B is a contagious liver disease that results ... as liver failure or liver cancer. How is hepatitis B spread? The hepatitis B virus is usually spread ...

374

Giant biliary cystadenoma complicated with polycystic liver: A case report  

PubMed Central

Biliary cystadenoma (BCA) is a rare hepatic neoplasm. Although considered a benign cystic tumor of the liver, BCA has a high risk of recurrence with incomplete excision and a potential risk for malignant degeneration. Correct diagnosis and complete tumor excision with negative margins are the mainstay of treatment. Unfortunately, due to the lack of presenting symptoms, and normal laboratory results in most patients, BCA is hard to distinguish from other cystic lesions of the liver such as biliary cystadenocarcinoma, hepatic cyst, hydatid cyst, Caroli disease, undifferentiated sarcoma, intraductal papillary mucinous tumor, and hepatocellular carcinoma. Ultrasound (US), computed tomography (CT) and magnetic resonance imaging (MRI) may be necessary. They demonstrate intrahepatic cystic lesions with features such as mural nodules, varying wall thickness, papillary projections, and internal septations. Nevertheless, surgery is still the only means of accurate diagnosis. Definitive diagnosis requires histological examination following formal resection. We describe a 57-year-old woman initially diagnosed with polycystic liver who was subsequently diagnosed with giant intrahepatic BCA in the left hepatic lobe. This indicates that both US physicians and hepatobiliary specialists should attach importance to hepatic cysts, and CT or MRI should be performed for further examination when a diagnosis of BCA is suspected.

Yang, Zhen-Zhen; Li, Yong; Liu, Jun; Li, Kuang-Fan; Yan, Ye-Hong; Xiao, Wei-Dong

2013-01-01

375

[Hepatic fascioliasis].  

PubMed

Hepatic fascioliasis is a pathology with an increasing incidence, morbidity and mortality all over the world and most particularly in our country, where endemic spots have been found, particularly in rural areas. Based on a clinical case which is supported by a revision of appropriate literature, the authors have made relevant considerations on bio-ecology, diagnosis, prognostic and treatment of this disease. PMID:9235854

Tavares, C; Freitas, P; Afonso, C

1997-01-01

376

Giant resonances: Progress, new directions, new challenges  

SciTech Connect

A review of some recent developments in the field of giant multipole resonances is presented. Particular emphasis is placed on directions that the authors feel will be followed in this field during the next several years. In particular, the use of high-energy heavy ions to excite the giant resonances is shown to provide exciting new capabilities for giant resonance studies. Among subjects covered are: Coulomb excitation of giant resonances, photon decay of giant resonances, the recent controversy over the identity of the giant monopole resonance, the most recent value for incompressibility of nuclear matter from analysis of giant monopole data, the isospin character of the 63 A/sup /minus/1/3/ GQR, agreement between (e,e/prime/) and (hadron, hadron/prime/) excitation of the giant quadrupole resonance, prospects for multiphonon giant resonance observation, and isolation of the isovector giant quadrupole resonance. 55 refs., 23 figs., 4 tabs.

Bertrand, J.R.; Beene, J.R.

1989-01-01

377

[Giant esophageal fibrovascular polyp].  

PubMed

Fibrovascular polyps are extremely rare benign neoplasias of the esophagus, which usually originate in the lower cricoid area. They do not produce any discomfort in the patient for a long time, however it may make itself evident by the patient's regurgitation of the polyp, producing asphyxia or, more frequently, dysphagia. The case of a 58 year old male patient is presented herein, with a 9 month record of dysphagia, weight loss and intermittent melena. The barium x-ray showed a distended esophagus, with a tumor running from the upper esophageal sphincter to the cardia. The endoscopy confirmed the presence of a pediculated tumor, implanted in the cervical esophagus. Surgeons suspected the potential malignancy of the tumor and performed a transhiatal esophagectomy. The final pathologic diagnosis was giant fibrovascular esophageal polyp. PMID:14532922

Palacios, Fernando; Contardo, Carlos; Guevara, Jorge; Vera, Augusto; Aguilar, Luis; Huamán, Manuel; Palomino, Américo; Yabar, Alejandro

2003-01-01

378

Cytomegalovirus-associated neonatal hepatitis.  

PubMed

Fifty-five patients with cytomegalovirus (CMV)-associated neonatal hepatitis (NH) were followed for 12 to 90 months. Six patients (10.9%) died from either a fulminant course or a chronic liver disease. Among the remaining 49 patients, whose liver function was completely recovered, there were eight with retardation of developmental or growth status, and two with hearing impairment. Overall, 20.4% of the survivors suffered from a long-term impact. The unfavorable outcome was related to several clinical and pathological parameters. These included persistence of clay-colored stool, presence of splenomegaly, ascites or anemia, high peak total and direct bilirubin, low nadir albumin levels, diffuse giant cell transformation and cirrhosis of the liver. The seropositivity of CMV infection did not significantly correlate with the outcome. PMID:1338353

Lai, M W; Chang, M H; Lee, C Y; Hsu, H C; Kau, C L

1992-01-01

379

Primary Intraosseous Cavernous Hemangioma of the Clivus: Case Report and Review of the Literature  

PubMed Central

Primary intraosseous hemangiomas are benign, vascular malformations that account for approximately 1% of all primary bone neoplasms. These tumors are mostly found in vertebral bodies and are rarely seen in the calvarium, where they represent 0.2% of bony neoplasms. When found in the skull, they tend to present with vague symptoms and do not have the typical radiological findings suggestive of hemangiomas. Because of this, these tumors can be missed in many cases or may be misinterpreted as more ominous lesions like multiple myeloma or osteosarcoma. Involvement of the skull base is exceedingly rare, and presentation with cranial nerve unilateral polyneuropathies has not been reported. We report a patient case with review of recent pertinent literature.

Gologorsky, Yakov; Shrivastava, Raj K.; Panov, Fedor; Mascitelli, Justin; Signore, Anthony Del; Govindaraj, Satish; Smethurst, Mark; Bronster, David J.

2013-01-01

380

Photodynamic Therapy for Diffuse Choroidal Hemangioma in Sturge-Weber Syndrome  

PubMed Central

Purpose. To report the treatment outcome of photodynamic therapy with verteporfin (PDT) for exudative retinal detachment (RD) associated with diffuse choroidal hemangioma in Sturge-Weber syndrome (SWS). Methods. An interventional case report of a 10-year-old girl with SWS who developed an exudative RD (visual acuity hand motions) that was treated with PDT. She was treated with a first session of multispot PDT. Posteriorly, a choroidotomy for drainage of subretinal fluid was created, combined with an intravitreal injection of gas (SF6) and cryoapplication. Finally, a second session of PDT was applied. Results. Subretinal fluid resolved over a period of one year and visual acuity increased to 20/125. Conclusions. PDT is an effective therapeutic option for exudative RD associated with diffuse choroidal hemangioma.

Monteiro, Silvia; Casal, Ines; Santos, Marinho

2014-01-01

381

Epithelioid Hemangioma Involving Three Contiguous Bones: a Case Report with a Review of the Literature  

PubMed Central

An epithelioid hemangioma involving three contiguous bones in continuity has, to the best of our knowledge, not been reported in the literature. A case of a 48-year-old man presented with radiating pain to the lower thoracic region for two years. A radiograph and CT scan revealed both permeative osteolytic and multiple trabeculated lesions involving the left posterior part of the 10th rib as well as the 9th and 10th vertebral bodies in continuity and was misled as a malignant or infectious lesion. The histopathology and immuno-histochemistry of the lesion confirmed the diagnosis of an epithelioid hemangioma. The lesion was still stable as of three years after surgery.

Jinawath, Arthit; Jaovisidha, Suphaneewan

2010-01-01

382

[Cavernous hemangioma of the spongious body of the urethra: a case report].  

PubMed

Urethral hemangiomas are rare and benign tumors, probably originating from a unipotent angioblastic stem cell. They can vary in size and the clinical appearance can range from asymptomatic lesions to urethral bleeding or gross hematuria. We present the case of an 18-year-old male, with a history of urethral bleeding. Cystourethoscopy revealed a solitary bulging mass into the lumen, about 6 cm far from the external meatus. Doppler study confirmed that the lesion was in communication with the vessels of the left spongious body. The patient underwent surgical removal of the lesion. The post-procedure Doppler study revealed an inflammation-based remodeling of the spongoius urethra and the absence of the previous vascular connection. At the time of publication the patient is still symptom-free. The surgical removal of urethral hemangiomas is by far the technique of choice for treating such lesions in young patients, thus avoiding side effects of LASER treatments. PMID:22760936

Abbinante, Maria; Crivellaro, Simone; Guaitoli, Paolo; Mastrocinque, Giuseppe; Ammirati, Enrico; Frea, Bruno

2012-07-01

383

Near-infrared laser treatment of complicated hemangiomas in children: ten-year clinical experience  

NASA Astrophysics Data System (ADS)

Results of application of low invasive laser technology (developed by authors: Proc. SPIE 5863, 107-115 (2005), Russian Federation patent No.2290228 of.27.12.06) to treatment of hemangiomas in children are presented and analyzed in this work. From 2001 the technology was applied to about 1500 children with more than 2000 hemangiomas. Majority of them were complicated ones: belong to cavernous or combined types or (and) were localized on problem places: on face near eyes, nose, and lips, on auricles, on perineum near anus and genitals, in respiratory and gastrointestinal tracts. Diode laser with wavelength 920, 970, and 1060 nm at distant and interstitial irradiation were applied. In case of need there applied endoscopes. Excellent and good results have been achieved in 94% cases; there was a significant improvement in the rest cases.

Abushkin, Ivan A.; Privalov, Valeriy A.; Lappa, Alexander V.

2011-02-01

384

Snapping hip caused by a venous hemangioma of the gluteus maximus muscle: a case report  

PubMed Central

Introduction Snapping hip, or coxa saltans, is defined as a clinical condition where a usually painful, audible snap occurs during hip flexion and extension. Its causes can be divided into external, internal or intra-articular origin. Accurate diagnosis is a prerequisite to successful treatment. We report a rare cause of snapping hip which is different from any previously reported cases. Case presentation A 23-year-old man presented to us with right hip pain of more than 10 years duration. Atrophy of the right gluteus maximus with snapping and tenderness were also noted. The imaging study revealed a focal intramuscular lesion in the lateral portion of the right gluteus maximus muscle. Surgery was performed and pathological examination concluded this mass to be a venous hemangioma. Conclusion Intramuscular hemangioma, though rare, should be considered in the differential diagnosis of a snapping hip even though muscle fibrosis is most frequently encountered.

Lin, Cheng-Li; Huang, Ming-Tung; Lin, Chii-Jeng

2008-01-01

385

A case of pulmonary sclerosing hemangioma with low 18FDG uptake in PET  

PubMed Central

Pulmonary sclerosing hemangioma (PSH) is a relatively rare benign neoplasm, often asymptomatic and presenting as a solitary pulmonary nodule on radiological imaging studies. In the present case report, we examined a case of PSH in a young adult female, and reviewed the literature pertaining to PSH with an emphasis on 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18FDG PET/CT) and pathology. Immunohistochemical staining was also performed to confirm the diagnosis of sclerosing hemangioma. The results revealed that the tumor cells were immunopositive for epithelial membrane antigen, thyroid transcription factor-1 and vimentin and cytoskeleton 7. The patient recovered and was discharged. Thus, 18FDG PET/CT may be used in the diagnosis of a solitary benign pulmonary nodule.

CHEN, QINGYONG; WU, LI JUN; HU, HUIZHEN; SONG, JIA; WU, YUQUAN; YAN, JIE; SHI, JIANGUO

2011-01-01

386

Sphincter-saving procedure for treatment of diffuse cavernous hemangioma of the rectum and sigmoid colon  

Microsoft Academic Search

Two cases of diffuse cavernous hemangioma of the rectum and rectosigmoid colon are reported. Sphincter-saving procedures were\\u000a applied as the surgical treatment for these two patients. The diseased rectum and distal sigmoid colon were resected 3 cm\\u000a above the pectinate line. The mucosa of the rectal stump was extirpated. All visible residue from the hemangiomatous tissues\\u000a on the muscular cuff,

Chen-Hwu Wang

1985-01-01

387

Diffuse cavernous hemangioma of the rectum: Report of a case and review of the literature  

Microsoft Academic Search

Summary  Various aspects of diffuse cavernous hemangioma of the rectum are discussed. The clinical features of chronic rectal bleeding,\\u000a often beginning in infancy, the proctoscopic findings of fleshy mucosal rectal folds, and the radiologic findings of multiple\\u000a rectal phleboliths, all serve to establish the diagnosis of this rare disease. Abdominoperineal excision of the rectum is\\u000a considered by the authors to be

G. A. Bell; A. D. McKenzie; Helen Emmons

1972-01-01

388

Endoscopic transnasal cryo-assisted removal of an orbital cavernous hemangioma: a technical note.  

PubMed

The cryoprobe device is commonly used by orbital surgeons for the extraction of intraorbital lesions. Cryoprobes provide a safe mechanism to manipulate fluid-filled tumors. Such lesions can present in locations in which intraoperative neurosurgical assistance is essential. The authors describe a technique whereby removal of an orbital hemangioma was facilitated by the aid of an endoscopic, transnasal cryoprobe while standard microsurgical dissection was performed concurrently via a transconjunctival approach. PMID:21509724

Campbell, P G; Yadla, S; Rosen, M; Bilyk, J R; Murchison, A P; Evans, J J

2011-02-01

389

Diffuse Choroidal Hemangioma: Report of a Clinicopathological Study in a 4YearOld Boy  

Microsoft Academic Search

The authors examined the clinicopathologic features of a 4-year-old boy with a diffuse choroidal hemangioma, yet without any features of the Sturge-Weber syndrome. The tumor occurred as a grayish intraocular mass with an overlying retinal detachment and was highly reflective in the ultrasonic examination. After contrast, the CT scan revealed diffuse thickening of the ocular wall associated with an enhanced

J. M. Riss; N. J. J. Girard; H. Proust; G. Lebreuil; C. A. Raybaud; B. Ridings

1995-01-01

390

[Compressive vertebral hemangioma. The contribution of imaging technics to diagnosis and pretherapeutic evaluation].  

PubMed

From a serie of ten cases of compressive vertebral hemangiomas (H.V.C.), the interest of different imaging methods was evaluated. CT scan and M.R.I. were the best imaging modalities in most cases. A CT guided biopsy was necessary in three cases to differentiate from metastasis. Angiography permitted to establish the vascular patterns and to evaluate the usefulness of embolization performed in six cases. PMID:2630923

Gaston, A; Laredo, J D; Assouline, E; Combes, C; Meder, J F

1989-01-01

391

The use of laser and Varioscope in the management of hemangiomas and vascular malformations.  

PubMed

Vascular lesions are common in infants and children and can be grouped into two main classifications: vascular tumors and vascular malformations. Hemangiomas are proliferative lesions characterized by increased endothelial cell turnover. Vascular malformations are congenital abnormalities involving capillaries, veins and/or lymphatics. A multidisciplinary approach regarding diagnosis and treatment of vascular anomalies in children is crucial. Several options are available for the treatment of hemangiomas. Since January 2003, 14 cases of hemangioma located in the cervicofacial region were treated at "La Sapienza" University. Seven patients underwent surgical resection, using Varioscope, and seven laser therapy. The Varioscope is an operating microscope, which is mounted on the head. Specific advantages convinced the authors to use the Varioscope initially. Autofocus, a magnification range between 3.6-7.2X and automatic parallax control allow unlimited freedom of movement which alleviates the discomfort of keeping the same distance for a long time. Laser therapy can selectively destroy specific targets within the skin by using an appropriate wavelength and pulse duration. Laser treatment parameters are based on several factors, including lesion location, lesion morphology, and patient skin type. The purpose of our study was aesthetic and functional improvement in patients comparing surgical and laser therapy. We obtained an aesthetic improvement in 11 patients and local pain control in all patients. Analysis of the cosmetic results was subjective but all parents indicated satisfaction with their decision regarding their child's treatment. PMID:16722347

Chiummariello, S; Mezzana, P; Fioramonti, P; Onesti, M G; Alfano, C; Scuderi, N

2006-01-01

392

Effects of propranolol and isoproterenol on infantile hemangioma endothelial cells in vitro  

PubMed Central

The aim of the present study was to investigate the effects of propranolol and isoproterenol on the growth curve of infantile hemangioma endothelial cells (IHECs) in vitro and determine the functions of the ?-adrenergic receptor in the pathogenesis of infantile hemangioma. IHECs were divided into three groups: The control group, the propranolol group (PG) and the isoproterenol group (IG). The PG and IG were administered with high, medium and low concentrations of the corresponding drugs. The cell growth in each group was determined using the MTT assay. A high propranolol concentration resulted in the inhibition of cell growth. By comparison, isoproterenol promoted cell growth. Within a specific time-frame (72–96 h), high drug concentrations (20 ?g/ml) elicited strong effects on the cells. At certain concentrations, propranolol inhibited cell growth once the proliferation stage of IHECs had been affected for a specific length of time, whereas isoproterenol yielded opposite results. The ?-adrenergic receptor elicits an important effect in the pathogenesis of infantile hemangioma.

ZHU, YALIN; TUERXUN, AERZIGULI; HUI, YAN; ABLIZ, PARIDE

2014-01-01

393

Surgical Outcomes of Transconjunctival Anterior Orbitotomy for Intraconal Orbital Cavernous Hemangioma  

PubMed Central

Purpose To describe surgical outcomes for transconjunctival anterior orbitotomy for intraconal cavernous hemangiomas. Methods The medical records of 9 consecutive patients with intraconal cavernous hemangiomas who underwent surgical removal by transconjunctival anterior orbitotomy were retrospectively reviewed. The conjunctiva was incised and retracted with a traction suture. For large tumors, a rectus muscle was temporarily disinserted. Tenon's capsule was separated and the tumor was removed with a cryoprobe or clamp. Surgical outcomes, positions of the tumors, methods of approach, and intra- and post-operative complications were evaluated. Results The mean follow-up period was 33 ± 6.8 months. No bony orbitotomy was used in this technique and the cosmetic results were very satisfactory. All tumors were removed intact. In 4 patients, tumors were extirpated with the aid of a cryoprobe. No patients had residual proptosis or limitation of ocular movement. No signs of recurrence were noted in any cases at 33 months follow-up. No serious or permanent complications were observed during or after the operation. Conclusions Transconjunctival anterior orbitotomy is an important surgical procedure in the treatment of intraconal cavernous hemangiomas. It can produce an excellent result, even if the posterior border of the tumor abuts the orbital apex.

Cho, Kyong Jin; Paik, Ji-Sun

2010-01-01

394

Dubin-Johnson syndrome with multiple liver cavernous hemangiomas: report of a familial case  

PubMed Central

Dubin-Johnson syndrome (DJS) is a rare autosomal recessive inheritance disorder of bilirubin metabolism. Herein we reported a complicated but interesting case which is readily resulted in misdiagnosis or an indefinite diagnosis, and this is the first reported familial case of DJS with multiple liver cavernous hemangiomas. A 49-year-old man was referred to our hospital for jaundice and multiple low-density liver masses. Extensive laboratory investigations showed conjugated hyperbilirubinaemia and positive urine bilirubin. Microscopically, lesions were composed of blood-filled vascular channels of various sizes lined by a single layer of flat endothelial cells supported by fibrous tissue. Coarse brown granules presented in the hepatocytes of the liver lobules locating beside the tumor, particularly in the centrilobular hepatocytes, and the granules showed blue-green with Schmorl’s reaction lipofuscin staining. Interestingly, one of the patient’s six siblings (female) shared the same condition with him. The relationship between DJS and hemangiomas remains unclear, and it might be contributed to some hereditary factors, or probably occurred simultaneously by chance. It was certified that the true reason for the long-term unclear jaundice was DJS, which was presumed clinically to be caused by bile excretion obstacles associated with the hemangiomas. Liver biopsy and histochemical stain may be helpful to identify the reason of jaundice and avoid misdiagnosis or an indefinite diagnosis.

Li, Peifeng; Wang, Yingmei; Zhang, Jinmei; Geng, Ming; Li, Zengshan

2013-01-01

395

Acute recurrence of orbital cavernous hemangioma in a young man: a case report.  

PubMed

A 29-year-old man presented with a history of prominent left eye of 6 months' duration. He also reported fluctuating blurred vision since 15 days ago. On examination, proptosis of 3 mm was noted in the left eye. Computed tomography (CT scan) of the orbits showed a well-circumscribed, hyperdense, intraconal mass lesion in left orbit, located in the inferotemporal quadrant. Orbitotomy was performed, and the tumor was delivered with an intact capsule. The clinical diagnosis of cavernous hemangioma was confirmed on histopathologic examination. The presence of intact capsule was confirmed grossly and with histopathology. The patient returned 6 weeks after surgery with recurrent proptosis. Repeated CT scan showed a recurrent intraconal mass of similar characteristics as in the primary presentation. A repeated orbitotomy was done, and the tumor was removed intact. Histopathology of the recurrent tumor confirmed the diagnosis of cavernous hemangioma. We report a rare case of orbital cavernous hemangioma with short-term recurrence (6 weeks). PMID:22082599

Meena, Manju; Naik, Milind; Honavar, Santosh

2012-01-01

396

Central Retinal and Posterior Ciliary Artery Occlusion After Intralesional Injection of Sclerosant to Glabellar Subcutaneous Hemangioma  

SciTech Connect

The aim of this study is to describe vision loss caused by central retinal artery and posterior ciliary artery occlusion as a consequence of sclerotherapy with a polidocanol injection to a glabellar hemangioma. An 18-year-old man underwent direct injection with a 23-gauge needle of 1 mL of a polidocanol-carbon dioxide emulsion into the glabellar subcutaneous hemangioma under ultrasound visualization of the needle tip by radiologists. He developed lid swelling the next day, and 3 days later at referral, the visual acuity in the left eye was no light perception. Funduscopy revealed central retinal artery occlusion and fluorescein angiography disclosed no perfusion at all in the left fundus, indicating concurrent posterior ciliary artery occlusion. The patient also showed mydriasis, blepharoptosis, and total external ophthalmoplegia on the left side. Magnetic resonance imaging demonstrated the swollen medial rectus muscle. In a month, blepharoptosis and ophthalmoplegia resolved but the visual acuity remained no light perception. Sclerosing therapy for facial hemangioma may develop a severe complication such as permanent visual loss.

Matsuo, Toshihiko, E-mail: matsuot@cc.okayama-u.ac.j [Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Department of Ophthalmology (Japan); Fujiwara, Hiroyasu; Gobara, Hideo; Mimura, Hidefumi; Kanazawa, Susumu [Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Department of Radiology (Japan)

2009-03-15

397

[Deficiency of REM sleep in a patient with pontine cavernous hemangioma].  

PubMed

A 15-year-old girl had no REM sleep presumably due to a pontine cavernous hemangioma was reported. Her brain MRI revealed a cavernous hemangioma extending from the dorsal pontine to the medulla. She manifested truncal ataxia, facial nerve palsy, and ocular motor apraxia. She could not sleep in the supine position due to the sleep apnea accompanied with loud snoring. Overnight polysomnography (PSG) was performed for detection of obstructive sleep apnea syndrome (OSAS). In addition to severe OSAS and Cheyne-Stokes-like respiration at wake after sleep onset, her 1st PSG study revealed no periods with rapid eye movement, EEG characteristic of REM sleep, atonia and variation on respiratory and heart rate. Even after effective therapy for OSAS with non-invasive positive airway pressure ventilation (NPPV), her 2nd PSG also failed to show stage REM. These findings suggest that this pontine cavernous hemangioma disturbed her REM-on system. This is the first report of an individual with long-term loss of REM sleep and a valuable case for the understanding of anatomical structures of the REM-on system and the role of REM in memory consolidation. PMID:19764454

Kagitani-Shimono, Kuriko; Kato-Nishimura, Kumi; Kitai, Yoshihiro; Araya, Ken; Tominaga, Koji; Okinaga, Takeshi; Mohri, Ikuko; Taniike, Masako; Ozono, Keiichi

2009-09-01

398

Spectra of Irradiated Giant Planets  

Microsoft Academic Search

As many as 101 extrasolar giant planets (EGPs) have been detected by radial-velocity techniques, but none has been detected directly by its own emission or by reflection of the light from its parent star. We review the current state-of-the-art in the theoretical modeling of the spectra of giant planets outside the solar system and the basic theory of EGP spectra

Adam Burrows; David Sudarsky

2002-01-01

399

Giant resonances in 112Sn  

NASA Astrophysics Data System (ADS)

The isoscalar giant quadrupole resonance and the giant monopole resonance in 112Sn were identified at Ex=13.3+/-0.2 MeV and 15.7+/-0.3 MeV, respectively, using small angle inelastic scattering of 129 MeV alpha particles. The nuclear incompressibility parameters for the volume term (Kvol), the surface term (Ksurf), and the symmetry term (Ksym) were determined including 112Sn.

Lui, Y.-W.; Bogucki, P.; Bronson, J. D.; Youngblood, D. H.; Garg, U.

1984-07-01

400

Hepatic granulomas as primary presentation of Mycobacterium avium infection in an HIV-negative, nonimmunosuppressed patient  

Microsoft Academic Search

Nontuberculous hepatic granuloma in patients not infected by human immunodeficiency virus (HIV) is rare. We report an 89-year-old\\u000a woman who presented with hepatic granuloma without lung involvement. Ultrasonography and computed tomography (CT) of the abdomen\\u000a showed low-density lesions in the liver. Histopathological examination of a liver biopsy revealed florid, caseating granulomatous\\u000a reaction with aggregates of epithelioid histiocytes and Langerhans-type giant

Megumi ToyodaHiroaki; Hiroaki Yokomori; Fumihiko Kaneko; Hide Yoshida; Akihiko Takahashi; Kenta Hoshi; Hajime Takeuchi; Kumiko Tahara; Hirobumi Kondo; Tadashi Motoori

2009-01-01

401

PDGFR-? (+) perivascular cells from infantile hemangioma display the features of mesenchymal stem cells and show stronger adipogenic potential in vitro and in vivo  

PubMed Central

Infantile hemangioma, a common benign tumor of infancy, grows quickly in the first year of life, and then regresses slowly to fibrofatty tissue in childhood. The accumulation of fibrofatty tissue in hemangioma involution indicates adipogenesis during this period. Perivascular cells (PCs) from multiple organs display multi-lineage differentiation, including adipogenesis. So we supposed that PCs in hemangioma may contribute to the adipogenesis in the involution. In this study, PDGFR-? (+) PCs was isolated from hemangioma tissue (hemangioma-derived perivascular cells, Hem-PCs) by fluorescence-activated cell sorter. In vitro, Hem-PCs showed fibroblast-like morphology. Immunofluorescence staining and flow cytometry showed Hem-PCs expressed MSCs markers CD105, CD90, CD29 and vimentin, pericyte markers ?-SMA and PDGFR-?, stem cell marker CD133, and the adipogenic transcription factor PPAR-?, but not hematopoietic/endothelial markers CD45, CD34, CD31, and flt-1. In vitro inductions confirmed multi-lineage differentiation of Hem-PCs, especially strong adipogenic potential. Then a murine model was established to observe in vivo differentiation of Hem-PCs by subcutaneous injection of cells/Matrigel compound into nude mice. The results showed Hem-PCs differentiated into adipocytes in vivo. To the best of our knowledge, this is the first study reporting the isolation of multipotential PDGFR-? (+) PCs from hemangioma, and observing their adipogenic differentiation in vivo. PCs may be the cellular basis of adipogenesis in hemangioma involution, and may be the target cells of adipogenic induction to promote hemangioma involution.

Yuan, Si-Ming; Guo, Yao; Zhou, Xiao-Jun; Shen, Wei-Min; Chen, Hai-Ni

2014-01-01

402

Hepatitis B therapy  

Microsoft Academic Search

The goal of hepatitis B treatment is to prevent cirrhosis, liver decompensation and hepatocellular carcinoma. In clinical practice, treatment response is determined by suppression of serum HBV DNA levels, hepatitis B e antigen seroconversion to hepatitis B e antibody, hepatitis B surface antigen loss, normalization of alanine aminotransferase levels and improvement in liver histology. Patients with life-threatening liver disease, and

Hellan Kwon; Anna S. Lok

2011-01-01

403

Therapy of Viral Hepatitis  

Microsoft Academic Search

Worldwide viral hepatitis is the most common cause of jaundice, chronic liver disease cirrhosis and hepatocellular carcinoma. While important advances have been made in prevention of viral hepatitis, therapy of this disease remains unsatisfactory. There are no specific therapies of proven benefit for acute hepatitis, although use of alpha-interferon during the acute phase of hepatitis C may result in a

Jay H. Hoofnagle

1998-01-01

404

A Tentorial Venous Hemangioma Presenting As an Extra-Axial Mass in the Ambient Cistern: A Case Report  

PubMed Central

Although venous hemangiomas are one of the most common soft-tissue tumors, venous hemangiomas in the central nervous system are extremely rare. We present an unusual case of venous hemangioma originating from the interdural space of the tentorium. A 32-year-old woman was incidentally found to have extra-axial mass occupying the left ambient cistern. This tumor was observed for the first 4 years as it was completely asymptomatic. Surgical resection was later recommended when the tumor grew. The mass originated from between the two layers of the anteromedial tentorial incisura. There were no findings indicative of previous hemorrhage inside the mass. The matrix of the mass was firm and vascular, resembling a fibrous meningioma. Gross total resection was achieved without any neurological deficit. Pathological examination revealed a dense fibrous connective tissue with a proliferation of vessels marked by thickened walls. A spindle cell proliferation in the vessel walls did not stain with the antibody to S-100 protein. Movat stain demonstrated the venous character of the vessels. These results were histologically compatible with a venous hemangioma. Albeit extremely rare, a venous hemangioma, a distinct clinical and pathological entity from a venous angioma, can present an intracranial mass lesion.

Oya, Soichi; Prayson, Richard A.; Lee, Joung H.

2012-01-01

405

Giant retinal tears.  

PubMed

A giant retinal tear (GRT) is a full-thickness neurosensory retinal break that extends circumferentially around the retina for three or more clock hours in the presence of a posteriorly detached vitreous. Its incidence in large population-based studies has been estimated as 1.5% of rhegmatogenous retinal detachments, with a significant male preponderance, and bilaterality in 12.8%. Most GRTs are idiopathic, with trauma, hereditary vitreoretinopathies and high myopia each being causative in decreasing frequency. The vast majority of GRTs are currently managed with a pars plana vitrectomy; the use of adjunctive circumferential scleral buckling is debated, but no studies have shown a clear anatomical or visual advantage with its use. Similarly, silicone oil tamponade does not influence long-term outcomes when compared with gas. Primary and final retinal reattachment rates are achieved in 88% and 95% of patients, respectively. Even when the retina remains attached, however, visual recovery may be limited. Furthermore, fellow eyes of patients with a GRT are at higher risk of developing retinal tears and retinal detachment. Prophylactic treatment under these circumstances may be considered but there is no firm evidence of its efficacy at the present time. PMID:24138895

Shunmugam, Manoharan; Ang, Ghee Soon; Lois, Noemi

2014-01-01

406

Clump Giants in the Hyades  

NASA Technical Reports Server (NTRS)

The project is entitled 'Clump Giants in the Hyades.' This observation of one of the late-type Hyades giants (Gamma Tau) has implications for understanding the formation of late-type stellar coronae as a function of the evolutionary state of the star. The Hyades giants are interesting because they are all clump giants in the Helium burning phase, similar to the cool primary of Capella. The Hyades giants show significantly more magnetic activity than expected from their state of evolution (and slowed-down rotation). Thus these systems provide an important clue to dynamo action. The data were obtained by the satellite on 13 March 2001 for a total RGS exposure of 58220 seconds. These data were delivered to the PI on 7 August 2001. The data could not be reprocessed until SAS Version 5.3.3 which became available 7 June 2002. Although the guidelines for assessing background rates suggested that half the data were contaminated, it does not appear that the spectral region of the RGS was adversely affected by unusually high background. The spectra show strong lines of Fe XVII and XVIII, O VII and VIII, Ne IX and X, along with numerous weaker lines. The emission measure distribution is highly reminiscent of Capella; if anything, the emission measure distribution is steeper at 6 million K than for Capella. Gamma Tau is the second brightest of the Hyades clump giants. Pallavicini et al. have shown that the luminosity of the brightest Hyades giant (Theta Tau) is remarkably similar to its luminosity as measured by Einstein. Short-term variability is also modest. We are addressing the variability issue now for Gamma Tau. Initial results were reported at the 2003 Seattle AAS meeting. A paper is in preparation for submission to the Astrophysical Journal.

Mushotzky, Richard F. (Technical Monitor); Brickhouse, Nancy

2003-01-01

407

Laparoscopic treatment of simple hepatic cysts and polycystic liver disease  

Microsoft Academic Search

  Background: The authors present their experience in the laparoscopic management of hepatic cysts and polycystic liver disease\\u000a (PLD). Methods: Between January 1996 and January 2002, 16 patients underwent laparoscopic liver surgery. Indications were\\u000a solitary giant cysts (n = 10) and PLD (n = 6). Data were collected retrospectively. Results: Laparoscopic fenestration was\\u000a completed in 15 patients. Median operative time was

P. Fiamingo; U. Tedeschi; M. Veroux; U. Cillo; A. Brolese; A. Da Rold; C. Madia; G. Zanus; D. F. D'Amico

2003-01-01

408

Gravitational scattering by giant planets  

NASA Astrophysics Data System (ADS)

We seek to characterize giant-planet systems by their gravitational scattering properties. We do this to a given system by integrating it numerically along with a large number of hypothetical small bodies that are initially in eccentric habitable zone (HZ)-crossing orbits. Our analysis produces a single number, the escape rate, which represents the rate at which the small-body flux is perturbed away by the giant planets into orbits that no longer pose a threat to terrestrial planets inside the HZ. Obtaining the escape rate this way is similar to computing the largest Liapunov exponent as the exponential rate of divergence of two nearby orbits. For a terrestrial planet inside the HZ, the escape rate value quantifies the "protective" effect that the studied giant-planet system offers. Therefore, escape rates could provide information on whether certain giant-planet configurations produce a more desirable environment for life than the others. We present some computed escape rates on selected planetary systems, focusing on effects of varying the masses and semi-major axes of the giant planets. In the case of our Solar System we find rather surprisingly that Jupiter, in its current orbit, may provide a minimal amount of protection to the Earth.

Laakso, T.; Rantala, J.; Kaasalainen, M.

2006-09-01

409

Hepatic hydrothorax.  

PubMed

Hepatic hydrothorax is defined as a pleural effusion in patients with liver cirrhosis in the absence of cardiopulmonary disease. The estimated prevalence among patients with liver cirrhosis is approximately 5-6%. The pathophysiology involves the passage of ascitic fluid from the peritoneal cavity to the pleural space through diaphragmatic defects. The diagnosis is made from clinical presentation and confirmed by diagnostic thoracentesis with pleural fluid analysis. The initial medical management is sodium restriction and diuretics, but liver transplantation provides the only definitive therapy. For patients who are not transplant candidates and those who await organ availability, other therapeutic modalities that are to be considered include transjugular intrahepatic portosystemic shunt placement, videoassisted thoracoscopic surgery repair, pleurodesis, and vasoconstrictors (eg, octreotide and terlipressin). The primary therapeutic goals are to reduce ascitic fluid production and improve symptoms to bridge the time for liver transplantation. PMID:23085762

Baikati, Kiran; Le, Duong L; Jabbour, Ibrahim I; Singhal, Shashideep; Anand, Sury

2014-01-01

410

Hepatitis B  

Microsoft Academic Search

Opinion statement  \\u000a \\u000a \\u000a \\u000a \\u000a – \\u000a \\u000a The management of acute HBV infection is supportive.\\u000a \\u000a \\u000a \\u000a \\u000a – \\u000a \\u000a Specific treatment is not indicated for HBV carriers because they often have no evidence of liver injury, and, further, do\\u000a not respond to currently available therapies.\\u000a \\u000a \\u000a \\u000a \\u000a – \\u000a \\u000a Interferon monotherapy is best indicated for patients with chronic replicating HBV infection and evidence of chronic hepatitis.\\u000a There is an increased

Tiffany Weakley; K. Rajender Reddy

1999-01-01

411

Giant Cell Arteritis and Polymyalgia Rheumatica  

MedlinePLUS

... Return to Web version Giant Cell Arteritis and Polymyalgia Rheumatica Overview What is giant cell arteritis? Arteritis (say: “ ... the temporal arteritis or cranial arteritis. What is polymyalgia rheumatica? Polymyalgia rheumatica (say: “pol-lee-my-al-jah ...

412

Elevated T-box 2 in infantile hemangioma stem cells maintains an adipogenic differentiation-competent state  

PubMed Central

Infantile hemangioma is a benign vascular tumor that affects 4 to 10% of neonates. A unique feature of hemangiomas is the natural lifecycle, whereby the tumor rapidly grows and then spontaneously regresses to a fibrofatty residuum. We have shown that hemangiomas are derived from multipotential stem cells (hemSCs), which differentiate into endothelial cells during the early proliferating phase and into adipocytes during the later involutive phase. T-box 2 (TBX2) is a transcription factor involved in controlling cell-fate decisions, and is highly expressed during the proliferating phase of hemangioma development. We hypothesize that TBX2 expression would be high in hemSCs derived from human hemangiomas and inhibiting TBX2 would result in changes in hemSC differentiation potential. To test our hypothesis, we analyzed hemSCs for TBX2 mRNA and protein expression. We then used RNA interference and TBX2 overexpression to determine the effect of altering TBX2 levels on hemSC growth and differentiation. Our studies show that TBX2 is highly expressed in hemSCs compared with a panel of normal stem/progenitor cells and mature vascular cells. TBX2 knockdown completely abolished adipogenic differentiation of hemSCs without significantly altering growth. Furthermore, overexpression of TBX2 led to enhanced adipogenic differentiation ability possibly through induction of C/EBP?. From these findings, we believe that TBX2 is active in hemSCs and that TBX2 maintains an adipogenic differentiation-competent state of hemSCs. These findings may be important in the development of better treatment options for hemangiomas to accelerate involution.

Todorovich, Sydney M.; Khan, Zia A.

2013-01-01

413

Structure of giant muscle proteins  

PubMed Central

Giant muscle proteins (e.g., titin, nebulin, and obscurin) play a seminal role in muscle elasticity, stretch response, and sarcomeric organization. Each giant protein consists of multiple tandem structural domains, usually arranged in a modular fashion spanning 500 kDa to 4 MDa. Although many of the domains are similar in structure, subtle differences create a unique function of each domain. Recent high and low resolution structural and dynamic studies now suggest more nuanced overall protein structures than previously realized. These findings show that atomic structure, interactions between tandem domains, and intrasarcomeric environment all influence the shape, motion, and therefore function of giant proteins. In this article we will review the current understanding of titin, obscurin, and nebulin structure, from the atomic level through the molecular level.

Meyer, Logan C.; Wright, Nathan T.

2013-01-01

414

Giant lobelias exemplify convergent evolution  

PubMed Central

Giant lobeliads on tropical mountains in East Africa and Hawaii have highly unusual, giant-rosette growth forms that appear to be convergent on each other and on those of several independently evolved groups of Asteraceae and other families. A recent phylogenetic analysis by Antonelli, based on sequencing the widest selection of lobeliads to date, raises doubts about this paradigmatic example of convergent evolution. Here I address the kinds of evidence needed to test for convergent evolution and argue that the analysis by Antonelli fails on four points. Antonelli's analysis makes several important contributions to our understanding of lobeliad evolution and geographic spread, but his claim regarding convergence appears to be invalid. Giant lobeliads in Hawaii and Africa represent paradigmatic examples of convergent evolution.

2010-01-01

415

In Search of the Giant Squid  

NSDL National Science Digital Library

The truth about this mysterious giant based on the exhibit by the National Museum of Natural History. A complete guide to the giant squid, including the different species of squid, how squid move, eat, and defend themselves, as well as photographs from the exhibit. Features also include information on the vessels and equipment used to investigate the giant squid, the locations where the giant squid were searched for, and a daily journal of the expedition.

416

Hepatitis D Co-Infection  

MedlinePLUS

... News Calendar of Events Personal Stories HBF Annual Report What is Hepatitis B? ABC's of Viral Hepatitis About Hepatitis B Hepatitis B Co-Infection Your Liver & Its Functions Donating Blood Glossary ...

417

A Case of Intraorbital Hemangioma Diagnosed with Tc 99m Labeled Erythrocyte Scintigraphy and Magnetic Resonance Imaging  

PubMed Central

We present a 20 year-old male patient who had prominent positional proptosis of the right eye and admitted to the hospital for tonsillectomy operation. After conventional ophthalmological examination, magnetic resonance imaging (MRI) and Tc 99m labeled erythrocyte scintigraphy were performed to confirm the diagnosis. Although it is rare to perform scintigraphy for this pathology, the visualization of intraorbital hemangioma was very obvious and we would like to present the visualization of the intraorbital hemangioma both with scintigraphy and MRI. Conflict of interest:None declared.

Balc?, Tansel Ansal; Koc, Zeyra P?nar; Turgut, Burak; Ayd?n, Ayse Murat; Busra Demirel, Bedriye

2011-01-01

418

Mechanism of giant pulses in radio pulsars  

SciTech Connect

Giant radio pulses are explained in terms of induced Compton scattering by the secondary plasma particles in pulsar magnetosphere. This process can account for the energetics and statistics of giant pulses as well as for their substructure at nanosecond timescales. The mechanism suggested predicts strong polarization of giant radiation in the plane of the ambient magnetic field.

Petrova, S.A. [Institute of Radio Astronomy NAS of Ukraine, Chervonopraporna Str., 4, 61002 Kharkov (Ukraine)

2005-11-22

419

Infrared spectrophotometry of Baade's Window M giants  

Microsoft Academic Search

Spectrophotometry is presented over 0.45-2.45 microns of a representative sample of M3-M9 giants in Baade's Window for comparison with local giants of similar spectral types. Bulge M giants of the same class are less luminous bolometrically by about 1.9 mag, are hotter by about 200-250 degrees, and have higher gravities.

A. E. Whitford; D. M. Terndrup; Jay A. Frogel

1990-01-01

420

Cabergoline Treatment in Invasive Giant Prolactinoma  

PubMed Central

Patients with invasive giant prolactinoma suffer from a constellation of symptoms including headache, blurred vision, lethargy, and sexual dysfunction. Cabergoline, a potent dopamine agonist, is a known medication prescribed for the treatment of invasive giant prolactinoma. Here, we report a case of invasive giant prolactinoma in a 52-year-old Saudi male with dramatic response to cabergoline treatment clinically, biochemically, and radiologically.

Alsubaie, Sadeem; Almalki, Mussa H

2014-01-01

421

New theory for giant loops.  

NASA Technical Reports Server (NTRS)

Four very large, shell-shaped features are known from the surveys of radio emission from the Galaxy. It is suggested that the giant loops represent a class of nebulae, induced by supernova radiation as opposed to supernova ejecta. The model considered provides a qualitative explanation for the spectral and polarization properties of the radio emission from giant loops. The radio emitting electrons are part of the general cosmic ray gas and need not arise specifically in the supernova that produced the fossil Stroemgren sphere.

Brandt, J. C.; Maran, S. P.

1972-01-01

422

Giant lichenification of the scalp.  

PubMed

Lichenification is characterized clinically by thickening of areas of skin as a result of the itch-scratch cycle and therefore is seen in conditions associated with chronic pruritus. The characteristic feature of giant lichenification is the occurrence of tumour-like growths with a warty cribriform surface. We describe a renal transplant patient presenting with giant lichenification of the scalp following an attack of herpes zoster at the same site. Chronic pruritus following scalp dysaethesia secondary to herpes zoster was considered the most likely explanation for the occurrence of these lesions. PMID:12780706

Arseculeratne, G; Altmann, P; Millard, P R; Todd, P; Wojnarowska, F

2003-05-01

423

Anastomosing hemangioma of the liver and gastrointestinal tract: an unusual variant histologically mimicking angiosarcoma.  

PubMed

Anastomosing hemangioma, a benign vascular neoplasm histologically simulating angiosarcoma, is newly recognized and has been described primarily in the genitourinary tract. We have encountered this lesion in the liver and gastrointestinal tract, where it can be diagnostically challenging, especially in core biopsy. Herein, we described 6 cases of anastomosing hemangioma of the liver and gastrointestinal tract. They occurred in 4 women and 2 men, ranging in age from 48 to 71 years. The tumors ranged from 0.2 to 6 cm (median, 3.1 cm) and were grossly well demarcated with a gray-brown spongy appearance. Microscopically, they had a loosely lobulated architecture. At higher magnification, lesions consisted of anastomosing sinusoidal capillary-sized vessels with scattered hobnail endothelial cells. Mild cytologic atypia occurred in all cases. Mitoses were absent. Vascular thrombi were seen in 4 cases (66.7%) without necrosis. One tumor (16.7%) featured prominent extramedullary hematopoiesis and 1 (16.7%) hyaline globules. Immunohistochemistry results were available for 3 cases, and the lesions stained with CD34 and/or CD31. Five cases had clinical follow-up information; there were no recurrences or metastases (range, 8 to 96 mo; mean, 41 mo), and 1 patient received no follow-up after a benign diagnosis on her colon polyp. In summary, anastomosing hemangioma of the liver and gastrointestinal tract is a rare distinctive vascular neoplasm displaying overlapping features with well-differentiated angiosarcoma. Despite small numbers and limited follow-up information in our series, evidence to date supports that the lesion is benign. Awareness of this entity is essential to avoid overdiagnosis and unnecessary aggressive treatment. PMID:23887160

Lin, Jingmei; Bigge, Jeremy; Ulbright, Thomas M; Montgomery, Elizabeth

2013-11-01

424

Initiation and Use of Propranolol for Infantile Hemangioma: Report of a Consensus Conference  

PubMed Central

Infantile hemangiomas (IHs) are common neoplasms composed of proliferating endothelial-like cells. Despite the relative frequency of IH and the potential severity of complications, there are currently no uniform guidelines for treatment. Although propranolol has rapidly been adopted, there is significant uncertainty and divergence of opinion regarding safety monitoring, dose escalation, and its use in PHACE syndrome (PHACE = posterior fossa, hemangioma, arterial lesions, cardiac abnormalities, eye abnormalities; a cutaneous neurovascular syndrome characterized by large, segmental hemangiomas of the head and neck along with congenital anomalies of the brain, heart, eyes and/or chest wall). A consensus conference was held on December 9, 2011. The multidisciplinary team reviewed existing data on the pharmacologic properties of propranolol and all published reports pertaining to the use of propranolol in pediatric patients. Workgroups were assigned specific topics to propose protocols on the following subjects: contraindications, special populations, pretreatment evaluation, dose escalation, and monitoring. Consensus protocols were recorded during the meeting and refined after the meeting. When appropriate, protocol clarifications and revision were made and agreed upon by the group via teleconference. Because of the absence of high-quality clinical research data, evidence-based recommendations are not possible at present. However, the team agreed on a number of recommendations that arose from a review of existing evidence, including when to treat complicated IH; contraindications and pretreatment evaluation protocols; propranolol use in PHACE syndrome; formulation, target dose, and frequency of propranolol; initiation of propranolol in infants; cardiovascular monitoring; ongoing monitoring; and prevention of hypoglycemia. Where there was considerable controversy, the more conservative approach was selected. We acknowledge that the recommendations are conservative in nature and anticipate that they will be revised as more data are made available.

Frommelt, Peter C.; Chamlin, Sarah L.; Haggstrom, Anita; Bauman, Nancy M.; Chiu, Yvonne E.; Chun, Robert H.; Garzon, Maria C.; Holland, Kristen E.; Liberman, Leonardo; MacLellan-Tobert, Susan; Mancini, Anthony J.; Metry, Denise; Puttgen, Katherine B.; Seefeldt, Marcia; Sidbury, Robert; Ward, Kendra M.; Blei, Francine; Baselga, Eulalia; Cassidy, Laura; Darrow, David H.; Joachim, Shawna; Kwon, Eun-Kyung M.; Martin, Kari; Perkins, Jonathan; Siegel, Dawn H.; Boucek, Robert J.; Frieden, Ilona J.

2013-01-01

425

The treatment of hemangiomas: with special reference to the role of steroid therapy.  

PubMed Central

Hemangiomas are the most common of all human birth defects. The author has reviewed a 25-year personal experience with treatment of over 1000 patients with a variety of common and rare developmental vascular anomalies. Attention is given to a more useful clinical classification of these disorders. The classification is intended to be helpful in estimating prognosis of the lesions and as a guide to the choice of therapy. Many treatment modalities are evaluated--some successful and some quite disappointing. Surgical excision, irradiation, CO2 freezing, sclerosing agents, cauterization, steroid therapy and watchful waiting are among the treatment methods evaluated. High dose--short course Prednisone therapy has proved to be a major new addition to the treatment of massive juvenile capillary hemangiomas. Numerous misconceptions have appeared in the medical literature. These are noted and a philosophic basis for present day management is suggested for each type angioma. The roles of growth, resolution, histologic picture and sense of deformity are considered in viewing the surgeon's approach to these difficult and challenging problems. Some evidence and speculations are offered as to the etiology, neurogenic influences and physiological dynamics of the various hemangiomas. Images Figs. 1a and b. Fig. 2a. Fig. 2b. Fig. 2c. Fig. 3a. Figs. 3b and 3c. Fig. 3d. Fig. 3e. Figs. 3f and g. Figs. 3h. Fig. 3i. Fig. 3j. Figs. 4a and b. Fig. 5a. Fig. 5b. Fig. 6. Fig. 7a. Fig. 7b. Fig. 7c. Fig. 8a. Fig. 8a. Fig. 8c.

Edgerton, M T

1976-01-01

426

Intravenous Lobular Capillary Hemangioma Occurring after Needle Insertion during Routine Health Checkup  

PubMed Central

Surgery was performed on a 53-year-old male patient with a painful mass in front of the elbow. The mass originally occurred after needle insertion during a routine health checkup and grew in size during a 1-year period. Intravenous tumor with arterio-venous fistula was diagnosed, and it was resected. Histopathological diagnosis of intravenous lobular capillary hemangioma was made. Occurrence of this tumor after a routine health checkup is rare. The etiology of this tumor occurring simultaneously with arteriovenous fistula is discussed.

Kakefuda, Toshihiro; Ono, Shigeshi; Matsuda, Shinsaku; Mori, Atsuo; Narimatsu, Yoshiaki; Hasegawa, Ichiro; Sato, Hiroaki; Tsukada, Jitsuro; Sugiura, Hitoshi; Irie, Rie

2013-01-01

427

Cavernous hemangioma of the urinary bladder in an 8-year-old child.  

PubMed

An 8-year-old boy was admitted to Ehime University Hospital, Ehime, Japan, for the further investigation of a 5-month episode of gross hematuria accompanied by lower abdominal pain. Magnetic resonance imaging revealed a solid tumor measuring 3 cm in diameter of the bladder wall. Cystoscopy demonstrated a red, wide-based, nodular tumor situated on the dome of the bladder. Histological examination of tissue taken at hot biopsy showed fibrolipoma. In consideration of potential malignancy, a partial cystectomy was carried out after informed consent was given. Histological examination of the resected specimen showed it to be cavernous hemangioma. PMID:15157217

Ikeda, Tetsuhiro; Shimamoto, Kenji; Tanji, Nozomu; Ohoka, Hiroji; Nishio, Shunji; Yokoyama, Masayoshi; Ikeda, Minoru

2004-06-01

428

Neuronavigation-guided endoscopic endonasal excision of an intraorbital intraconal cavernous hemangioma.  

PubMed

A 50-year-old man presented with the complaints of gradual decrease of visual acuity in his left eye since 2 years. Brain magnetic resonance imaging revealed a left intraorbital intraconal round mass lesion consistent with cavernous hemangioma. Binostril endoscopic endonasal approach was performed with the aid of neuronavigation. The lesion was well capsulated and easily dissected and resected totally without complication. Early postoperative course was uneventful. Three-month follow-up after surgery revealed that the visual acuity and visual fields of the patient were normalized, and magnetic resonance imaging demonstrated total excision of the lesion. PMID:21959438

Gazioglu, Nurperi; Abuzayed, Bashar; Tanriover, Necmettin

2011-09-01

429

Hypertrophic olivary degeneration following surgical excision of brainstem cavernous hemangioma: a case report.  

PubMed

Hypertrophic olivary degeneration (HOD) is a rare type of neuronal degeneration involving the dento-rubo-olivary pathway. It is distinguished from other types of neuronal degeneration in that hypertrophy, rather than atrophy, takes place in the neurons in the inferior olivary nucleus. Prior to the invention of Magnetic Resonance Imaging (MRI), HOD was difficult to be detected, and a firm diagnosis could only be made at autopsy. We present a case of bilateral HOD following surgical excision of a cavernous hemangioma in the brainstem. The literature and imaging findings of this uncommon condition are reviewed. PMID:10631896

Tsui, E Y; Cheung, Y K; Mok, C K; Yuen, M K; Chan, J H

1999-01-01

430

Huge Cavernous Hemangiomas Enveloping the Optic Nerve Successfully Removed by a Vertical Lid Split Orbitotomy  

PubMed Central

A 63-year-old woman presented with a 15-year history of gradually increasing proptosis of right eye. Ocular examination revealed proptosis of 9?mm with decreased visual acuity in her right eye. CT scan showed a well-circumscribed and enhancing orbital mass filling almost the entire right orbit. The tumor occupied the superolateral, superomedial, and inferomedial intraconal space, enveloping the optic nerve. Complete excision of two large intraconal tumors was performed successfully via a vertical lid split orbitotomy. Histopathologic examination confirmed the diagnosis of cavernous hemangioma. There were no intraoperative or postoperative complications. The patient achieved a satisfactory cosmetic outcome 1 year after surgery.

Yum, Jung-Hoon; Woo, Kyung In

2014-01-01

431

Huge cavernous hemangiomas enveloping the optic nerve successfully removed by a vertical lid split orbitotomy.  

PubMed

A 63-year-old woman presented with a 15-year history of gradually increasing proptosis of right eye. Ocular examination revealed proptosis of 9?mm with decreased visual acuity in her right eye. CT scan showed a well-circumscribed and enhancing orbital mass filling almost the entire right orbit. The tumor occupied the superolateral, superomedial, and inferomedial intraconal space, enveloping the optic nerve. Complete excision of two large intraconal tumors was performed successfully via a vertical lid split orbitotomy. Histopathologic examination confirmed the diagnosis of cavernous hemangioma. There were no intraoperative or postoperative complications. The patient achieved a satisfactory cosmetic outcome 1 year after surgery. PMID:24868473

Yum, Jung-Hoon; Kim, Yoon-Duck; Lee, Jung Hye; Woo, Kyung In

2014-01-01

432

Giant magnetoresistance in electrodeposited films  

Microsoft Academic Search

Electrodeposition is one of the simpler and cheaper processes available for the fabrication of thin metal films. Recent developments have made it possible to electrodeposit a wide range of nanostructured materials, including many that exhibit giant magnetoresistance (GMR). We review progress in the growth and characterization of such films, starting with electrodeposited ferromagnetic metal\\/non-magnetic metal superlattices in which the individual

W. Schwarzacher; D. S. Lashmore

1996-01-01

433

Controlling nucleation in giant liposomes.  

PubMed

We introduce giant liposomes to investigate phase transformations in picoliter volumes. Precipitation of calcium carbonate in the confinement of DPPC liposomes leads to dramatic stabilization of amorphous calcium carbonate (ACC). In contrast, amorphous strontium carbonate (ASC) is a transient species, and BaCO3 precipitation leads directly to the formation of crystalline witherite. PMID:24728476

Tester, Chantel C; Whittaker, Michael L; Joester, Derk

2014-04-29

434

Collective motion and giant resonances  

SciTech Connect

This book compiles the papers presented at the conference on the subject of collective motion and giant resonances. Specifically discussed topics are: Beta decay of nuclei and astrophysics; inner hole states and their fragmentation; quantum chrome-dynamics, nuclear reactions of uranium and collective excitations; electron-positron interactions and collective model.

Wilhelmi, Z.; Kicinska-Habior, M.

1986-01-01

435

Giant lipoma: a case report.  

PubMed

A lipoma is a fatty tissue tumor presenting as a painless slowly growing mass that can affect any part of the body rich in adipose tissue. Lipomas can be present in the thigh, shoulder, trunk, etc, although they are usually small. We are reporting a 65-year-old man with a giant lipoma involving his left buttock and lumbar region. PMID:23610489

Zaroo, Mohammad Inam; Bashir, Sheikh Adil; Mohsin, Mir; Baba, Peerzada Umar Farooq; Farooq, Syed Suraiya Arjumand; Zargar, Haroon Rashid

2011-07-01

436

Giant Lipoma: A Case Report  

PubMed Central

A lipoma is a fatty tissue tumor presenting as a painless slowly growing mass that can affect any part of the body rich in adipose tissue. Lipomas can be present in the thigh, shoulder, trunk, etc, although they are usually small. We are reporting a 65-year-old man with a giant lipoma involving his left buttock and lumbar region.

Zaroo, Mohammad Inam; Bashir, Sheikh Adil; Mohsin, Mir; Baba, Peerzada Umar Farooq; Farooq, Syed Suraiya Arjumand; Zargar, Haroon Rashid

2011-01-01

437

Giant Serpentine Aneurysms: Multidisciplinary Management  

PubMed Central

Summary Sixty-five cases of intracranial giant serpentine aneurysms (GS?s), including 61 cases reported in the literature and four additional cases presented in this study were reviewed. The clinical presentation, possible causes, natural history, and especially management of GSAs are discussed with emphasis on the need for aggressive intervention and multidisciplinary management.

Anshun, W.; Feng, L.; Daming, W.

2000-01-01

438

Drizzle correlations with giant nuclei  

Microsoft Academic Search

Giant nuclei (GN) concentrations (NGN) below RICO small cumulus clouds were substantially correlated with drizzle drop concentrations (Nd), especially at higher cloud altitudes. The NGN-Nd correlation coefficients (R) progressively increased with altitude whereas R for CCN concentrations with Nd were negative with mostly decreasing magnitudes at increasing altitudes. These results indicate that the positive influence of GN [or CCN with

James G. Hudson; Vandana Jha; Stephen Noble

2011-01-01

439

Eccentric Ellipsoidal Red Giant Binaries  

NASA Astrophysics Data System (ADS)

Ellipsoidal variables are binaries in which the primary star is distorted by the influence of its small, close companion. By modelling ellipsoidal variables at known distances, it is possible to determine the exact masses of both components, despite the absence of eclipses. We study a sample of red giant ellipsoidal variables, also known as sequence E stars, in the Large Magellanic Cloud. Roughly 10% of these ellipsoidal red giants have light curves with non-sinusoidal shapes, suggestive of eccentric orbits. We recently presented the first radial velocity curves confirming the eccentricity of these variables. Significant eccentricities in evolved binaries are not unknown, but remain unexplained by classical tidal theory. Using both light and radial velocity curves of these eccentric ellipsoidal red giant binaries, we modelled the systems using the Wilson-Devinney code, to obtain the system parameters including exact masses. We also find evidence that the shape of the red giant changes throughout the orbit due to the high eccentricity and the varying influence of the companion. Defining the parameters of these systems paves the way for modelling to determine by what mechanism eccentricity is maintained in evolved binaries.

Nicholls, Christine; Wood, P.

2012-05-01

440

Hepatitis (For Parents)  

MedlinePLUS

... adults. Most are not approved for use in children but some are used in select circumstances. Not all patients with hepatitis B require medication. The treatment of chronic hepatitis C has improved significantly with the use ...

441

Hepatitis C (image)  

MedlinePLUS

Hepatitis C is a virus-caused liver inflammation which may cause jaundice, fever and cirrhosis. Persons who are most at risk for contracting and spreading hepatitis C are those who share needles for injecting drugs ...

442

Hepatitis B Test  

MedlinePLUS

... IgM; anti-HBe; Hepatitis B e Antibody; HBV DNA Formal name: Hepatitis B Virus Testing Related tests: ... of tests detect or evaluate the genetic material ( DNA ) of the virus. The pattern of test results ...

443

Hepatitis C and Incarceration  

MedlinePLUS

... Hepatitis C from one person to another. Tattoos/Piercing/Scarring: Sex: The Hepatitis C virus can be ... can be spread when tattoo, body art, or piercing equipment has tiny amounts of blood on it. ...

444

Hepatitis B Foundation  

MedlinePLUS

... Other Helpful Links Welcome to the Hepatitis B Foundation Top Stories HBV Therapy May Cut Liver Cancer ... national coalition co-chaired by the Hepatitis B Foundation and the Association of Asian Pacific Community Health ...

445

Viral Hepatitis Therapies  

MedlinePLUS

... brand name for additional information. Approved Treatments for Hepatitis B Brand Name Generic Names Manufacturer Name Indication Baraclude entecavir Bristol-Myers Squibb chronic hepatitis B virus infection with evidence of active viral replication ...

446

Hepatitis B Vaccination Protection  

MedlinePLUS

... of those vaccinated will develop immunity to the hepatitis B virus. The vaccine causes no harm to those ... vaccination. This written opinion is limited to whether hepatitis B vaccination is indicated for the worker and if ...

447

Hepatitis B Symptoms  

MedlinePLUS

... JavaScript on. Read more information on enabling JavaScript. Hepatitis B Skip Content Marketing Share this: Main Content Area Symptoms Hepatitis B does not always cause obvious symptoms. Children are ...

448

Nursery of Giants  

NASA Technical Reports Server (NTRS)

Hidden behind a shroud of dust in the constellation Cygnus is a stellar nursery called DR21, which is giving birth to some of the most massive stars in our galaxy. Visible light images reveal no trace of this interstellar cauldron because of heavy dust obscuration. In fact, visible light is attenuated in DR21 by a factor of more than 10,000,000,000,000,000,000,000,000,000,000,000,000,000 (ten thousand trillion heptillion).

New images from NASA's Spitzer Space Telescope allow us to peek behind the cosmic veil and pinpoint one of the most massive natal stars yet seen in our Milky Way galaxy. The never-before-seen star is 100,000 times as bright as the Sun. Also revealed for the first time is a powerful outflow of hot gas emanating from this star and bursting through a giant molecular cloud.

This image is a large-scale mosaic assembled from individual photographs obtained with the InfraRed Array Camera (IRAC) aboard Spitzer. The image covers an area about two times that of a full moon. The mosaic is a composite of images obtained at mid-infrared wavelengths of 3.6 microns (blue), 4.5 microns (green), 5.8 microns (orange) and 8 microns (red). The brightest infrared cloud near the top center corresponds to DR21, which presumably contains a cluster of newly forming stars at a distance of 10,000 light-years.

Protruding out from DR21 toward the bottom left of the image is a gaseous outflow (green), containing both carbon monoxide and molecular hydrogen. Data from the Spitzer spectrograph, which breaks light into its constituent individual wavelengths, indicate the presence of hot steam formed as the outflow heats the surrounding molecular gas. Outflows are physical signatures of processes that create supersonic beams, or jets, of gas. They are usually accompanied by discs of material around the new star, which likely contain the materials from which future planetary systems are formed. Additional newborn stars, depicted in green, can be seen surrounding the DR21 region.

The red filaments stretching across this image denote the presence of polycyclic aromatic hydrocarbons. These organic molecules, comprised of carbon and hydrogen, are excited by surrounding interstellar radiation and become luminescent at wavelengths near 8.0 microns. The complex pattern of filaments is caused by an intricate combination of radiation pressure, gravity and magnetic fields. The result is a tapestry in which winds, outflows and turbulence move and shape the interstellar medium.

To the lower left of the mosaic is a large bubble of gas and dust, which may represent the remnants of a past generation of stars.

2004-01-01

449

A Suspicious Breast Lesion Detected by Dynamic Contrast-Enhanced MRI and Pathologically Confirmed as Capillary Hemangioma: a Case Report and Literature Review  

PubMed Central

Breast capillary hemangioma is a type of benign vascular tumor which is rarely seen. Little is known about its presentation on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Here, we describe a case of suspicious breast lesion detected by DCE-MRI and pathologically confirmed as capillary hemangioma. Our case indicates that a small mass with a superficial location, clear boundary, and homogeneous enhancement on DCE-MRI indicates the possible diagnosis of hemangioma, whereby even the lesion presents a washout type curve.

Yang, Lian-He; Ma, Shuang; Li, Qing-Chang; Xu, Hong-Tao; Wang, Xin

2013-01-01

450

Prevention of viral hepatitis  

Microsoft Academic Search

Opinion statement  Despite the availability of vaccines against hepatitis A and B, acute viral hepatitis due to these agents continues to be\\u000a among the most commonly reported notifiable infectious diseases in the United States. Currently available hepatitis A and\\u000a B vaccines are highly immunogenic and well tolerated, but vaccine coverage needs to be expanded. Use of the hepatitis A vaccine\\u000a in

Raymond S. Koff

2002-01-01

451

Diclofenac induced hepatitis  

Microsoft Academic Search

Summary Diclofenac is a frequently prescribed nonsteroidal antiinflammatory drug (NSAID). Significant hepatotoxicity related to diclofenac may be more common than previously recognized, as three patients with diclofenac-associated hepatitis were seen by one clinician in a single year. All patients were ANA positive during the hepatitis and had histologic features of chronic active hepatitis. Two had been inappropriately treated with corticosteroids.

L. J. Scully; D. Clarke; R. J. Barr

1993-01-01

452

Treatment of hepatitis C  

Microsoft Academic Search

Hepatitis C virus is a leading cause of chronic liver disease, with over 170 million people infected worldwide. It is also the leading indication for liver transplantation. Complications from chronic hepatitis C infection include cirrhosis, hepatic decompensation, and hepatocellular carcinoma. As a result, treatment strategies to prevent such complications have been widely researched, although many questions remain unanswered. To date,

Andrew I. Kim; Sammy Saab

2005-01-01

453

Management of hepatic coma complicating viral hepatitis  

Microsoft Academic Search

The treatment is described of 17 patients with presumed viral hepatitis who developed hepatic coma unresponsive to standard conservative measures. Five patients were considered for treatment by exchange transfusion. Four were treated, with transient improvement in two, but all died. Nine patients were considered for treatment by heterologous liver perfusion. Six were treated, with transient improvement in two and complete

R. C. Pirola; J. M. Ham; R. G. Elmslie

1969-01-01

454

The course of incidental intraorbital cavernous hemangioma in a patient with myasthenia gravis treated with cyclosporine: a case report.  

PubMed

A 69-year-old woman presented with generalized myasthenia gravis and a left orbital cavernous hemangioma (OCH), which elevated the optic nerve and displaced the external eye muscles. Cyclosporine treatment induced a gradual size reduction in the OCH, and consequently contributed to improved external ocular symptoms in combination with immunosuppressant effects. PMID:24761144

Konno, Shingo; Hagiwara, Wataru; Sasaki, Miyuki; Fuse, Akihisa; Imamura, Tomomi; Inoue, Masashi; Kitazono, Hisao; Fujioka, Toshiki

2014-01-01

455

Propranolol inhibits angiogenesis via down-regulating the expression of vascular endothelial growth factor in hemangioma derived stem cell  

PubMed Central

Background: Oral propranolol (PRN) has recently been shown to be highly effective for infantile hemangiomas (IHs), and is currently recommended as the first-line treatment of complicated IHs. However, the therapeutic mechanism(s) still remain unclear. Methods: In this study, we tested hemangioma-derived stem cells for expression of vascular endothelial growth factor (VEGF) in vitro and studied the inhibition of VEGF expression. We used PCR, Elisa, Western blotting and immunohistochemistry in vivo and in vitro trial. Results: The study demonstrated that application of PRN at a “normal” concentration equivalent to plasma concentration did not inhibit proliferation or promote apoptosis of hemangioma derived stem cells (HemSCs) isolated from IH patients. PRN suppressed expression of vascular endothelial growth factor (VEGF) and basic Fibroblast Growth Factor (bFGF) in HemSCs in vitro. Morphological, histological and immunohistological improvement were observed in vivo using murine IH model in which HemSCs pre-treated with PRN were implanted into BALB/c-nu mice. In the pre-treated HemSC grafts, mean micro-vessel density (MVD) significantly decreased and protein levels of VEGF markedly decreased, while bFGF was still detectable. Conclusions: The results suggested PRN inhibited angiogenesis via down-regulating the expression of vascular endothelial growth factor in hemangioma derived stem cell. These findings provide critical insight into the potential mechanisms of PRN action on IH.

Zhang, Ling; Mai, Hua-Ming; Zheng, Jing; Zheng, Jia-Wei; Wang, Yan-An; Qin, Zhong-Ping; Li, Ke-Lei

2014-01-01

456

Propranolol, a very promising treatment for ulceration in infantile hemangiomas: A study of 20 cases with matched historical controls  

Microsoft Academic Search

BACKGROUND: Ulceration is a common but poorly understood complication of infantile hemangiomas (IH) that is difficult to control. OBJECTIVE: To investigate the possible role of monotherapy with propranolol for ulcerating IH. METHODS: Propranolol was given to 20 patients with IH, who suffered from ulceration at the start of treatment (mean age at onset of treatment, 3.5 months; standard error of

Denise Josephina Johanna Hermans; Ingrid Mathilde van Beynum; Leonardus Jan Schultze Kool; Peter Cornelius Maria van de Kerkhof; Marcus Henricus Wilhelmus Andreas Wijnen; Catharina Joanna Maria van der Vleuten

2011-01-01

457

Congenital tri-cavernous hemangiomas of the right buccal region, right accessory parotid gland, and masseter muscle region.  

PubMed

We report a rare case of congenital tri-cavernous hemangiomas of the right buccal region, right accessory parotid gland, and masseter muscle region in an adult. The patient, a 25-year-old woman, complained of 3 masses in her right midcheek. Ultrasonographic and computed tomographic findings showed an irregular-shaped mass (multiple calcifications) with a well-defined margin in the masseter muscle region, an ellipse-shaped mass (multiple calcifications) with a well-defined margin in the right buccal region, and a comma-shaped mass (no calcifications) with a well-defined margin separate from the parotid gland in the right accessory parotid gland region. These iconographic findings suggested that the masses were all hemangiomas separately originating from the parotid gland, accessory parotid gland, and masseter muscle. The masses were completely removed through a standard parotid incision without postoperative facial palsy, skin deformity, and difficulty in secreting saliva. Findings from histologic examination of the tumor revealed multiple, thin-walled, and dilated blood vessels, confirming the diagnosis of cavernous hemangiomas. Ultrasonographic and computed tomographic findings were extremely useful in diagnosing the mass/masses as hemangioma before surgery, clarifying relationships between the mass and adjacent structures, and determining the surgical approach to the mass/masses. PMID:24621721

Yang, Tao; Gu, Yongchun; Zhang, Li; Hua, Zequan

2014-03-01

458

The Course of Incidental Intraorbital Cavernous Hemangioma in a Patient with Myasthenia Gravis Treated with Cyclosporine: A Case Report  

PubMed Central

A 69-year-old woman presented with generalized myasthenia gravis and a left orbital cavernous hemangioma (OCH), which elevated the optic nerve and displaced the external eye muscles. Cyclosporine treatment induced a gradual size reduction in the OCH, and consequently contributed to improved external ocular symptoms in combination with immunosuppressant effects.

Konno, Shingo; Hagiwara, Wataru; Sasaki, Miyuki; Fuse, Akihisa; Imamura, Tomomi; Inoue, Masashi; Kitazono, Hisao; Fujioka, Toshiki

2014-01-01

459

Intradural Extramedullary Capillary Hemangioma in the Upper Thoracic Spine: A Review of the Literature  

PubMed Central

Capillary hemangiomas are benign tumors found in the skin and soft tissues in younger people. They occur in the central nervous system only rarely, and intradural occurrence is extremely rare. We report here a 60-year-old man presenting with thoracic girdle pain and progressive gait disturbance. Magnetic resonance images of the thoracic spine showed a 12 × 8 × 20?mm, well-defined intradural mass at the T2 level, compressing the spinal cord laterally. Relative to the spinal cord, the mass was hypo- to isointense on T1-weighted images and relatively hyperintense on T2-weighted images, with strong enhancement on contrast-enhanced T1-weighted images. The patient underwent T1-2 hemilaminectomy with resection of the intradural extramedullary tumor, which showed characteristics of a capillary hemangioma on histologic examination. The patient's symptoms improved following the surgery and no clinical or radiological evidence of recurrence was noted at the 2-year follow-up. We present this case with a review of the literature, highlighting features for differential diagnosis.

Sakai, Toshinori; Higashino, Kosaku; Goda, Yuichiro; Tezuka, Fumitake; Sairyo, Koichi

2014-01-01

460

Breast cancer risk among Swedish hemangioma patients and possible consequences of radiation-induced genomic instability.  

PubMed

Breast cancer incidence among 17,158 female Swedish hemangioma patients was analyzed with empirical excess relative risk models and with a biologically-based model of carcinogenesis. The patients were treated in infancy mainly by external application of radium-226. The mean and median absorbed doses to the breast were 0.29 and 0.04Gy, and a total of 678 breast cancer cases have been observed. Both models agree very well in the risk estimates with an excess relative risk and excess absolute risk at the age of 50 years, about the mean age of breast cancer incidence, of 0.25Gy(-1)(95% CI 0.14; 0.37) and 30.7 (10(5) BYR Gy)(-1) (95% CI 16.9; 42.8), respectively. Models incorporating effects of radiation-induced genomic instability were developed and applied to the hemangioma cohort. The biologically-based description of the radiation risk was significantly improved with a model of genomic instability at an early stage of carcinogenesis. PMID:19416732

Eidemüller, Markus; Holmberg, Erik; Jacob, Peter; Lundell, Marie; Karlsson, Per

2009-10-01

461

A case of von Hippel-Lindau disease with juxtapapillary retinal capillary hemangioma and nutcracker phenomenon.  

PubMed

The aim of this study was to evaluate a patient with von Hippel-Lindau (VHL) syndrome and to discuss the clinical manifestations. A 25-year-old woman presented to our clinic with blurred vision for 2 months. Best corrected visual acuity in right eye was 20/50, and fundoscopic examination revealed juxtapapillary endophytic retinal capillary hemangioma. Examination findings on left eye were normal. On optical coherence tomography, exudation was prominent on macula. History revealed cerebellar operation because of cerebellar hemangioblastoma. On abdominal ultrasonography, liver hemangiomas and pancreatic cysts were seen, confirmed by abdominal computerized tomography (CT). Abdominal CT imaging also revealed nutcracker phenomenon. Transthoracic echocardiography showed atrial septal aneurysm without shunt. The patient refused ocular treatment. At 3-month control, ophthalmic findings were the same. To our knowledge, this is the first case of VHL disease reported to be associated with nutcracker phenomenon and atrial septal aneurysm. Systemic evaluation and regular follow-up should be recommended to subjects with VHL disease. PMID:23114531

Yava?, Güliz Fatma; Okur, Nazan; Küsbeci, Tuncay; Norman, Esma; Inan, Ümit

2013-06-01

462

E-selectin is present in proliferating endothelial cells in human hemangiomas.  

PubMed Central

E-selectin, an endothelial-cell-specific leukocyte adhesion molecule, may also function in angiogenesis. To investigate its role in a noninflammatory angiogenic disease, E-selectin was analyzed by immunohistochemistry in specimens of proliferative phase and involutive phase hemangiomas. Hemangioma is an endothelial cell tumor of capillary blood vessels that grows rapidly during infancy and regresses spontaneously during childhood. E-selectin expression was high in proliferative phase specimens and was co-localized with dividing microvascular endothelial cells. Relative to the number of blood vessels, E-selectin declined significantly in involutive phase specimens demonstrating that E-selectin correlates with angiogenesis in the tumors. E-selectin was not detected in quiescent endothelium but was co-localized in dividing microvascular endothelial cells in placenta and neonatal foreskin, two tissues with ongoing growth of microvessels. These in vivo studies support the hypothesis that E-selectin functions in angiogenesis and suggest that E-selectin may be a marker for proliferating endothelium. Images Figure 1 Figure 2 Figure 3 Figure 4

Kraling, B. M.; Razon, M. J.; Boon, L. M.; Zurakowski, D.; Seachord, C.; Darveau, R. P.; Mulliken, J. B.; Corless, C. L.; Bischoff, J.

1996-01-01

463

Role of MRI in the diagnosis and evaluation of cavernous hemangioma of the arm  

PubMed Central

Abstract Sinusoidal hemangioma is a rare type of cavernous hemangioma with different clinico-pathological aspects. They are usually localized in the extremities with interest in the subcutaneous layer. The new imaging techniques play an important role in diagnosis, evaluation and follow-up of these types of tumors. We describe the case of a 21-year-old patient, four times operated for a recurrent soft tissue tumor, located intramuscularly in the distal third of the upper limb. Plain X-ray and computer tomography (CT) showed a nonspecific mass with calcification. The MRI (magnetic resonance imaging) exam demonstrated a lobulated heterogeneous signal tumor mass in the biceps brachial muscles, with high signal intensity on T2 weighted images and intermediate signal on T1 weighted images. MRI accurately assessed the extent of the tumor and evaluated the recurrence. MRI imagings combined with contrast-enhanced sequences were used to classify the lesions in low flow vascular disorders. CT angiography with multiplanar reconstructions (MPR), maximum intensity projections (MIP) and volume-rendered reconstructions (VR) was useful in confirming the venous origin of the tumor.

Ciurea, ME; Bondari, S; Stoica, LE; Gheonea, IA

2014-01-01

464

Role of MRI in the diagnosis and evaluation of cavernous hemangioma of the arm.  

PubMed

Sinusoidal hemangioma is a rare type of cavernous hemangioma with different clinico-pathological aspects. They are usually localized in the extremities with interest in the subcutaneous layer. The new imaging techniques play an important role in diagnosis, evaluation and follow-up of these types of tumors. We describe the case of a 21-year-old patient, four times operated for a recurrent soft tissue tumor, located intramuscularly in the distal third of the upper limb. Plain X-ray and computer tomography (CT) showed a nonspecific mass with calcification. The MRI (magnetic resonance imaging) exam demonstrated a lobulated heterogeneous signal tumor mass in the biceps brachial muscles, with high signal intensity on T2 weighted images and intermediate signal on T1 weighted images. MRI accurately assessed the extent of the tumor and evaluated the recurrence. MRI imagings combined with contrast-enhanced sequences were used to classify the lesions in low flow vascular disorders. CT angiography with multiplanar reconstructions (MPR), maximum intensity projections (MIP) and volume-rendered reconstructions (VR) was useful in confirming the venous origin of the tumor. PMID:24653757

Ciurea, M E; Bondari, S; Stoica, L E; Gheonea, I A

2014-03-15

465

Propranolol in Treatment of Huge and Complicated Infantile Hemangiomas in Egyptian Children  

PubMed Central

Background. Infantile hemangiomas (IHs) are the most common benign tumours of infancy. Propranolol has recently been reported to be a highly effective treatment for IHs. This study aimed to evaluate the efficacy and side effects of propranolol for treatment of complicated cases of IHs. Patients and Methods. This prospective clinical study included 30 children with huge or complicated IHs; their ages ranged from 2 months to 1 year. They were treated by oral propranolol. Treatment outcomes were clinically evaluated. Results. Superficial cutaneous hemangiomas began to respond to propranolol therapy within one to two weeks after the onset of treatment. The mean treatment period that was needed for the occurrence of complete resolution was 9.4 months. Treatment with propranolol was well tolerated and had few side effects. No rebound growth of the tumors was noted when propranolol dosing stopped except in one case. Conclusion. Propranolol is a promising treatment for IHs without obvious side effects. However, further studies with longer follow-up periods are needed.

Hassan, Basheir A.; Shreef, Khalid S.

2014-01-01