Note: This page contains sample records for the topic giant hepatic hemangioma from
While these samples are representative of the content of,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of
to obtain the most current and comprehensive results.
Last update: November 12, 2013.

Arterial Embolization of Giant Hepatic Hemangiomas  

SciTech Connect

Hepatic cavernous hemangiomas are usually small and asymptomatic. They are usually discovered incidentally and only a few require treatment. However, giant hemangiomas may cause symptoms,which are indications for treatment. We describe four cases of symptomatic giant hepatic hemangiomas successfully treated with transcatheter arterial embolization, performed with polyvinyl alcohol particles. There were no complications. Follow-up with clinical and imaging examinations showed disappearance of symptoms and decrease in size of lesions.

Giavroglou, Constantinos; Economou, Hippolete; Ioannidis, Ioannis [Department of Radiology, AHEPA Hospital, Aristotle University of Thessaloniki (Greece)



Ruptured giant hepatic hemangioma: report of a case.  


Hemangiomas are the most common benign liver masses with a frequency of 0.4-7.3% at autopsy. They are usually discovered incidentally and a few require surgery. Spontaneous or traumatic ruptures are among indications of surgery for hemangiomas. We report a case of giant hepatic hemangioma presenting as hemoperitoneum following use of the slimming belt that underwent an emergent laparotomy. Abdominal exploration revealed that both right and left lobes of the liver were involved with giant hemangiomas. The liver was compressed by tightly packing laparotomy pads. After the operation, the patient was admitted to the surgical intensive care unit. Two days later, a second surgery was performed to remove the laparotomy pads. On the 6th day, the patient was discharged. One month later, to shrink the tumor, percutaneous transarterial embolization of the hepatic artery was performed. PMID:21287486

Jangjoo, Ali; Mehrabi Bahar, Mostafa; Aliakbarian, Mohsen


Giant hepatic hemangioma and cross-fused ectopic kidney in a spaceflight participant.  


Commercial spaceflight participants are typically older than traditional astronauts and often have medical conditions that make medical certification for flight difficult. This case report considers a 43-yr-old spaceflight participant who planned a short-duration Soyuz flight to the International Space Station (ISS). While he participated in many hazardous activities such as parachuting, hang gliding, scuba diving, Antarctic and jungle exploration, and deep sea submersible operations, he knew that several of his medical conditions precluded serving as a career astronaut. At the time of his initial spaceflight prescreen examination, he was known to have previous bilateral photorefractive keratectomy (PRK) for myopia and a cross-fused left ectopic kidney that would be disqualifying for a career astronaut. During the evaluation for the left single cross-fused ectopic kidney, a giant hepatic hemangioma was also discovered. In order to medically qualify for flight, the giant hepatic hemangioma was surgically removed. This case summary investigat*es the implications of a single cross-fused left ectopic kidney and the decision process and treatment implications for spaceflight medical certification in an individual with an asymptomatic giant hepatic hemangioma. PMID:20131656

Jennings, Richard T; Garriott, Owen K; Bogomolov, Valery V; Pochuev, Vladimir I; Morgun, Valery V; Garriott, Richard A



[Successful anesthetic management for resection of a giant hepatic hemangioma with Kasabach-Merritt syndrome using FloTrac system].  


Kasabach-Merritt syndrome (KMS) is a rare and severe coagulation disorder caused by vascular malformations within or outside the liver. It is characterized by profound thrombocytopenia, microangiopathic hemolytic anemia, and consumption coagulopathy. We successfully managed the anesthesia for a giant hemangioma resection complicated with KMS using FloTrac/Vigileo system. A 78-year-old woman (51 kg, 141 cm) was admitted for giant hemangioma with disseminated intravascular coagulation (DIC). General anesthesia was induced with sevoflurane and remifentanil. Epidural anesthesia was not induced because of coagulopathy. We evaluated arterial pressure-based cardiac output (APCO), stroke volume variation (SVV) as a predictor for fluid responsiveness, systolic blood pressure (SBP), and central venous pressure (CVP) during the operation. Prior to tumor resection, 6,000 ml of fluid was suctioned from the tumor. The increase of SVV and sudden decrease of APCO and SBP were recognized during surgical procedure. The SVV demonstrated marked changes in response to hemorrhage, and it was more sensitive than CVP change during operation. We conclude that SVV is an accurate predictor of intravascular hypovolemia, and it is a useful indicator for assessing the appropriateness and timing of applying fluid for improving circulatory stability during a giant hemoangioma resection. PMID:22175175

Wakabayashi, Saiko; Yamaguchi, Keisuke; Kugimiya, Toyoki; Inada, Eiichi



Embolization for management of hepatic hemangiomas.  


Hemangiomas represent the most common primary tumor of the liver. Clinically the significance of these lesions is highly variable. The management of hemangiomas is controversial and is intimately related to the size, symptoms, and associated comorbidities of the patients who harbor these benign tumors. Series suggest that the vast majority of hemangiomas are less than 4 cm, asymptomatic, and clinically incidental findings. Symptomatic hemangiomas are large and associated with a constellation of vague upper abdominal complaints including pain, mass, distention, early satiety, and weight loss. A number of small series of surgically treated symptomatic hemangiomas have demonstrated enucleation as a safe and effective intervention. We report a collection of case reports using embolization as a primary treatment of symptomatic hemangiomas. The first patient is a 73-year-old black man previously treated for prostate cancer by radical prostatectomy and radiation. He developed weight loss, abdominal fullness, and early satiety. His symptoms were attributed to a large left lateral segmental liver mass that was biopsy proven to be a hemangioma. The second patient is a 49-year-old black women who complained of weakness, fatigue, night sweats, and anemia. The only abnormality discovered was a large right posterior hemangioma. The third patient is a 49-year-old black women with unexplained right upper quadrant pain and anemia who was found to have a 19 x 11 x 7.5-cm left hepatic hemangioma by CT. All three patients underwent elective treatment of their hemangiomas with highly selective hepatic embolization. There were no significant complications related to the procedures. Symptoms resolved for all patients acutely after treatment. The use of embolization for hepatic hemangiomas provides safe and effective treatment of the patient's symptoms while avoiding operative intervention, extended hospitalization, or postoperative recuperation. This treatment modality should be considered for the symptomatic hemangioma under elective conditions. PMID:11243541

Deutsch, G S; Yeh, K A; Bates, W B; Tannehill, W B



Role of SPECT\\/CT in diagnosis of hepatic hemangiomas  

Microsoft Academic Search

Abstract Abstract Abstract Abstract AIM: To investigate the role of SPECT\\/CT in the diagnosis of hepatic hemangiomas whose anatomical positions are not ideal, situated adjacent to the heart, the inferior cava, hepatic vessels or abdominal aorta, etc. METHODS: The hepatic perfusion, blood pool, and fusion imaging were carried out using SPECT\\/CT in 54 patients, who were suspected for hepatic hemangiomas.

Jian-Guo Zheng; Zhi-Ming Yao; Chong-Ye Shu; Ying Zhang; Xia Zhang


Laparoscopic radiofrequency ablation of hepatic cavernous hemangioma  

Microsoft Academic Search

Background  \\u000a Radiofrequency ablation (RFA), currently used extensively for liver tumors, also has been applied successfully to hepatic\\u000a cavernous hemangioma (HCH) percutaneously. The aim of this study was to assess the feasibility, safety, and efficacy of laparoscopic\\u000a RFA for patients with HCHs.\\u000a \\u000a \\u000a \\u000a Methods  Between March 2001 and March 2004, 27 patients with symptomatic and rapid-growth lesions were treated by laparoscopic RFA\\u000a using

R.-F. Fan; F.-L. Chai; G.-X. He; L.-X. Wei; R.-Z. Li; W.-X. Wan; M.-D. Bai; W.-K. Zhu; M.-L. Cao; H.-M. Li; S.-Z. Yan



Ultrasonography guided percutaneous radiofrequency ablation for hepatic cavernous hemangioma  

Microsoft Academic Search

AIM: Hepatic cavernous hemangioma (HCH) is the most common benign tumor of the liver and its management is still controversial. Recent success in situ radiofrequency ablation of hepatic malignancies has led us to consider using this technique in patients with HCH. This study was to assess the efficacy, safety, and complications of percutaneous radiofrequency ablation (PRFA) under ultrasonography guidance in

Yan Cui; Li-Yan Zhou; Man-Ku Dong; Ping Wang; Min Ji; Xiao-Ou Li; Chang-Wei Chen; Zi-Pei Liu; Yong-Jie Xu; Hong-Wen Zhang



Growing hepatic cavernous hemangioma demonstrated by Tc-99m red blood cell scintigraphy.  


Hepatic cavernous hemangiomas rarely grow. Although a few cases have been reported in the literature, none used Tc-99m red blood cell scintigraphy. The authors describe such a case here. PMID:10885690

Gorenberg, M; Sopov, W; Groshar, D



Acoustic Radiation Force Impulse Elastography for Focal Hepatic Tumors: Usefulness for Differentiating Hemangiomas from Malignant Tumors  

PubMed Central

Objective The purpose of this study is to investigate whether acoustic radiation force impulse (ARFI) elastography with ARFI quantification and ARFI 2-dimensional (2D) imaging is useful for differentiating hepatic hemangiomas from malignant hepatic tumors. Materials and Methods One-hundred-and-one tumors in 74 patients were included in this study: 28 hemangiomas, 26 hepatocellular carcinomas (HCCs), three cholangiocarcinomas (CCCs), 20 colon cancer metastases and 24 other metastases. B-mode ultrasound, ARFI 2D imaging, and ARFI quantification were performed in all tumors. Shear wave velocities (SWVs) of the tumors and the adjacent liver and their SWV differences were compared among the tumor groups. The ARFI 2D images were compared with B-mode images regarding the stiffness, conspicuity and size of the tumors. Results The mean SWV of the hemangiomas was significantly lower than the malignant hepatic tumor groups: hemangiomas, 1.80 ± 0.57 m/sec; HCCs, 2.66 ± 0.94 m/sec; CCCs, 3.27 ± 0.64 m/sec; colon cancer metastases, 3.70 ± 0.61 m/sec; and other metastases, 2.82 ± 0.96 m/sec (p < 0.05). The area under the receiver operating characteristics curve of SWV for differentiating hemangiomas from malignant tumors was 0.86, with a sensitivity of 96.4% and a specificity of 65.8% at a cut-off value of 2.73 m/sec (p < 0.05). In the ARFI 2D images, the malignant tumors except HCCs were stiffer and more conspicuous as compared with the hemangiomas (p < 0.05). Conclusion ARFI elastography with ARFI quantification and ARFI 2D imaging may be useful for differentiating hepatic hemangiomas from malignant hepatic tumors.

Kim, Ji Eun; Bae, Kyung Soo; Han, Joon Koo; Choi, Byung Ihn



A hepatic sclerosed hemangioma with significant morphological change over a period of 10 years: a case report  

PubMed Central

Introduction Liver cavernous hemangioma is the most common noncystic hepatic lesion, and a hemangioma that undergoes degeneration and fibrous replacement is called a hepatic sclerosed hemangioma. Case presentation A 63-year-old Japanese man was admitted for detailed investigation of a liver tumor. Tumor markers carcinoembryonic antigen, alpha-fetoprotein, and CA19-9 levels in the peripheral blood were not elevated at any time. Plain computed tomography showed an approximately 1.5cm low density mass in the periphery of segment 8, which was marginally enhanced on contrast-enhanced dynamic computed tomography. On magnetic resonance imaging, the tumor was hypointense on T1-weighted image and hyperintense on T2-weighted image. The tumor was suspected to be an atypical hemangioma, metastatic, hepatocellular carcinoma, or cholangiocellular carcinoma. Segmental hepatectomy was performed. Histological examination of the resected tumor specimen revealed a sclerosed hemangioma with marked hyalinization and sparse stromal fibrosis. Immunochemically, the tumor cells were positive for CD34 and alpha smooth muscle actin. Electron microscopically, the residual hemangioma consisted of numerous caveolae and vesicles in endothelial cells in irregular shapes and sizes. Immunostaining for caveolin-1 showed decreased or no caveolin-1 reactivity in the hyalinized lesions of the sclerosed hemangioma, but abundant caveolin-1 reactivity in the residual cavernous hemangioma. Of interest, computed tomography images of the tumor obtained 10 years earlier at our hospital depicted a 3cm typical cavernous hemangioma. Conclusions Hepatic sclerosed hemangioma is a rare condition. Comparison of radiological findings of the lesion over a period of 10 years was valuable in providing insight for the evolutional process from liver cavernous hemangioma to hepatic sclerosed hemangioma.



Metastatic Angiosarcoma of the Liver Preoperatively Presenting as Giant Hemangioma  

Microsoft Academic Search

Background: Hepatic angiosarcomas are rare tumors most often associated with exposure to vinyl chloride or other carcinogens. Only a few cases have been published without such a history. Case Report: We report the case of a 73-year-old woman who was admitted to our medical department with unclear upper abdominal pain, thrombocytopenia and anemia. Both computed tomography and magnet resonance imaging

Timo Kirschstein; Daniel Aeberli; Arthur Zimmermann; Waldemar Uhl; Markus W. Büchler



Infantile hepatic hemangiomas. Clinical features, radiologic investigations, and treatment of 20 patients  

SciTech Connect

The clinical features, radiologic investigation, and treatment of 20 infants with hepatic hemangiomas are presented. Palpable abdominal mass (n = 18) and cardiac failure (n = 11) were the common presenting features. Nine patients had hyperconsumptive coagulopathy. Seven patients had other hemangiomas. Ultrasound (n = 15) showed the number and distribution of the hemangiomas within the liver. Hypoechoic and hyperechoic elements were present in addition to prominent vascular channels and diminished caliber of the distal aorta. Radionuclide sulfur colloid (n = 12) and labeled red blood cell (n = 7) studies showed the distribution and vascularity of the hemangiomas. Computed tomography (n = 8) revealed central hypointensity with marked peripheral enhancement after contrast. Arteriography now performed only as a prelude to therapeutic embolization demonstrated hypervascularity in each patient, contrast pooling in six and early draining veins in five. Magnetic resonance scanning (n = 3) showed decreased signal intensity on T1 images and high intensity signal on T2. In two patients, there was resolution or improvement of the hemangiomas without therapy. Four patients had surgery (lobectomy (2), trisegmentectomy (1), and surgical evacuation of a central hematoma (1)). Steroids and radiation were given to seven patients, and one patient also required therapeutic embolization. Steroids were the initial therapy in five patients, one of whom later required therapeutic embolization and another cyclophosphamide. Two patients were treated initially with radiation therapy, one of whom also needed emergency hepatic artery ligation. Seventeen of the 20 patients are alive and well from 6 months to 14 years after diagnosis.

Stanley, P.; Geer, G.D.; Miller, J.H.; Gilsanz, V.; Landing, B.H.; Boechat, I.M. (Childrens Hospital of Los Angeles, CA (USA))



Giant Cavernous Hemangioma on Tc99m RBC Scan  

Microsoft Academic Search

A 36-year-old woman with right upper quadrant abdominal pain since three months previously and no other significant medical history was referred for evaluation of an abdominal mass. Upon clinical examination, a large palpable mass in the mid -upper abdominal area was noted. Abdominal ultrasound and spiral CT-scan showed a large hepatic mass in the left liver lobe. The patient was

Armaghan Fard-Esfahani; Mohammad Eftekhari


Interventional Treatment of a Symptomatic Neonatal Hepatic Cavernous Hemangioma Using the Amplatzer Vascular Plug  

SciTech Connect

Percutaneous intervention is one treatment option for symptomatic hepatic hemangioma in infants. We report the case of a newborn (birth weight 4060 g) with a large hepatic cavernous hemangioma, which presented early with high cardiac output failure due to arteriovenous shunting and signs of incipient Kasabach-Merritt syndrome. We performed a successful superselective transcatheter coil embolization of three feeding arteries on the seventh day of life. Because of remaining diffuse very small arteries causing a relevant residual shunt, additional occlusion of the three main draining veins was necessary with three Amplatzer vascular plugs. Cardiac failure resolved immediately. Without any additional therapy the large venous cavities disappeared within the following months. The tumor continues to regress in size 8 months after the intervention.

Kretschmar, Oliver, E-mail:; Knirsch, Walter [University Children's Hospital Zurich, Division of Pediatric Cardiology (Switzerland); Bernet, Vera [University Children's Hospital Zurich, Division of Neonatology and Pediatric Intensive Care (Switzerland)



Transcatheter Arterial Embolization of Two Symptomatic Giant Cavernous Hemangiomas of the Liver  

SciTech Connect

Cavernous hemangiomas are usually asymptomatic; however, a small percentage may cause symptoms. This case report discusses palliation by transcatheter arterial embolization with polyvinyl alcohol particles.

Althaus, Sandra; Ashdown, Boyd [Department of Radiology, Box 357115, University of Washington School of Medicine, 1959 NE Pacific Street, Seattle, WA 98195 (United States); Coldwell, Douglas [Department of Radiology, Denver General Hospital, 303 Bannock Street, Denver, CO 80204-4507 (United States); Helton, W. Scott [Department of General Surgery, University of Washington School of Medicine, 1959 NE Pacific Street, Seattle, WA 98195 (United States); Freeny, Patrick C. [Department of Radiology, Box 357115, University of Washington School of Medicine, 1959 NE Pacific Street, Seattle, WA 98195 (United States)



Scintigraphy of hepatic hemangiomas: the value of Tc-99m-labeled red blood cells: concise communication  

SciTech Connect

Fourteen patients with hepatic hemangiomas were evaluated by Tc-99m colloid scintigraphy and Tc-99m RBC angiography, including flow studies and early and delayed static studies. On colloid scintigraphy, the liver appeared enlarged, with single or multiple focal defects. During the flow and early static Tc-99m RBC studies, the lesions showed poor perfusion and were filled only partially or not at all. Delayed Tc-99m RBC studies demonstrated the whole extent of the lesion and all the lesions when multiple hemangiomas were present. A flow study showing decreased perfusion and a late blood-pool study showing increased local blood volume appear characteristic of hemangiomas. Liver biopsy should not be attempted in such cases.

Royal, H.D.; Israel, O.; Parker, J.A.; Kolodny, G.M.



Postinfantile Giant Cell Hepatitis: An Etiological and Prognostic Perspective  

PubMed Central

Giant cell hepatitis is common manifestation in pediatric liver diseases, but quite uncommon in adults, only about 100 cases reported in the English literature in the last two decades. Data for the present review were identified by a structured PubMed/MEDLINE search from 1963 to December 2012, using keywords postinfantile giant cell hepatitis (PIGCH), adult giant cell hepatitis, and syncytial giant cell hepatitis in adults and liver. We report a case of postinfantile giant cell hepatitis along with the review related to the etiology and respective outcome, as the literature in the last 20 years suggests. This condition is probably due to idiosyncratic or cytopathic response of individual to various hepatocytic stimuli. It is purely a histomorphological diagnosis and does not establish the etiology. Autoimmune liver diseases are most common etiology, in around 40% of cases, but various viruses, drugs, posttransplant condition, and other causes also have been reported. Prognosis depends upon the etiology. In this paper, we emphasized various causative factors of PIGCH and their respective outcome in patients affected by them. We also highlighted the possible pathogenesis and histopathological spectrum of this entity on the basis of description given in various studies and our limited experience of few cases.

Bihari, Chhagan; Rastogi, Archana; Sarin, Shiv Kumar



Postinfantile giant cell hepatitis: an etiological and prognostic perspective.  


Giant cell hepatitis is common manifestation in pediatric liver diseases, but quite uncommon in adults, only about 100 cases reported in the English literature in the last two decades. Data for the present review were identified by a structured PubMed/MEDLINE search from 1963 to December 2012, using keywords postinfantile giant cell hepatitis (PIGCH), adult giant cell hepatitis, and syncytial giant cell hepatitis in adults and liver. We report a case of postinfantile giant cell hepatitis along with the review related to the etiology and respective outcome, as the literature in the last 20 years suggests. This condition is probably due to idiosyncratic or cytopathic response of individual to various hepatocytic stimuli. It is purely a histomorphological diagnosis and does not establish the etiology. Autoimmune liver diseases are most common etiology, in around 40% of cases, but various viruses, drugs, posttransplant condition, and other causes also have been reported. Prognosis depends upon the etiology. In this paper, we emphasized various causative factors of PIGCH and their respective outcome in patients affected by them. We also highlighted the possible pathogenesis and histopathological spectrum of this entity on the basis of description given in various studies and our limited experience of few cases. PMID:23555054

Bihari, Chhagan; Rastogi, Archana; Sarin, Shiv Kumar



Airway Management in a Toddler with a Giant Hemangioma of the Tongue  

PubMed Central

Background Induction of general anesthesia in a patient with compromised airway has always caused dilemma to anesthesiologist, especially for toddler this is paramounted. Case Presentation An 18 month old boy had a huge sized lingual mass which not only filled entire oral cavity but protruded outside the mouth up to about 5 cm. Having in mind the diagnosis of hemangioma, prior to induction it was attempted to reduce the mass but could be reduced only minimally by manual decompression. While the tongue, still outside the mouth, with full preparedness for anesthesia was induced maintaining the spontaneous ventilation. During laryngoscopy and intubation the tongue was pulled out of the oral cavity to ease the passage of the endotracheal tube. The mass was excised successfully and patient had an uneventful postoperative course. Conclusion Maintenance of spontaneous ventilation is the crucial safety element during induction.

Hajipour, Asghar; Javid, Mihan J.; Saedi, Babak



Hemangioma cavernoso gigante de seno maxilar. Reporte de un caso y revisión de la literatura Giant cavernous hemangioma of the maxillary sinus. Case report and literature review  

Microsoft Academic Search

RESUMEN Los hemangiomas son neoplasias vasculares benignas que se presentan de preferencia en la región cervicofacial, siendo raros en las fosas nasales y excepcionales en los senos paranasales, con pocos casos reportados. Se presenta un paciente de sexo masculino y 33 años de edad, que consultó por obstrucción nasal, aumento de volumen maxilar y exoftalmo izquierdo de 2 años de

Alfredo Naser G; Arturo Samith M; Carlos Ríos D


Giant hepatic angiomyolipoma simulating focal nodular hyperplasia.  


A case of hepatic angiomyolipoma occurring in a 41-year-old woman, the eighteenth case in literature, is reported herein. The radiographic imagings of the tumor simulated those of focal nodular hyperplasia; namely, the tumor was hyperechoic on ultrasound, hypodense on computed tomography, hypervascular on angiography, and exhibited an uptake of technetium (Tc)-99m phytate. The diagnosis was established after successful removal of the huge tumor from the right hepatic lobe. Histologically, the tumor was angiomyolipoma which was made up of three components, blood vessels, smooth muscle and fatty tissue. Furthermore, extramedullary hematopoiesis, which is usually seen in this tumor was confirmed. The differentiation of hepatic angiomyolipoma from FNH is also discussed. PMID:3404779

Miyahara, M; Kobayashi, M; Tada, I; Okada, K; Sato, K; Kim, Y I; Hiraoka, T; Yokoyama, S



Liver Hemangioma  


Liver hemangioma Basics In-Depth Multimedia Expert Answers Resources Reprints A single copy of this article may be reprinted for personal, noncommercial use only. Liver hemangioma By Mayo Clinic staff Original Article: http:// ...


Giant Hepatic Cyst with Septal Structure: Diagnosis and Management  

PubMed Central

The hepatic cyst is a common benign liver tumor, and no surgical treatment is necessary. However, it is difficult to correctly diagnose the giant hepatic cyst containing the solid septal structures inside, from the malignant cystadenocarcinomas. The various imaging modalities such as computed tomography, magnetic resonance imaging, and ultrasonography, have been developed and are useful for the diagnosis of these liver tumors. Reviewing the other reports in this paper, the combination of more than 2 modalities will help to diagnose these tumors; however, the malignant potential is unable to be excluded if the tumor is huge. Therefore, the surgical resection should be considered for the huge hepatic cysts with septal structures if the correct diagnosis is unable to be made. For example, when the hemorrhages cause the granulation in the septa which often shows neovascularization, the imaging modalities are unable to define this situation from the malignant tissue with hypervascularity. Therefore, with the careful review of other reports, we conclude that if the imaging studies show the possible malignant potential or the sizing-up is marked, the surgical treatment should be considered with the consent from the patients.

Sato, Toshihiro; Imai, Michitaka; Hayashi, Kazunao; Isokawa, Osamu; Nomura, Tatsuya; Tsuchiya, Yoshiaki



Hepatic Cavernous Hemangiomas: Relationship between Speed of Intratumoral Enhancement during Dynamic MRI and Apparent Diffusion Coefficient on Diffusion-Weighted Imaging  

PubMed Central

Objective To investigate the relationships between the apparent diffusion coefficients (ADCs) on diffusion-weighted imaging (DWI) and the speed of contrast-enhancement in hepatic hemangiomas. Materials and Methods Sixty-nine hepatic hemangiomas (? 1 cm) were evaluated with DWI, by using multiple b values (b = 50, 400, 800 s/mm2), followed by a gadolinium-enhanced dynamic MRI. The lesions were classified into three groups, according to the speed of contrast-enhancement on the portal phase. ADCs were measured on the ADC map automatically, and were calculated by using the two different b values (mADC50-400 with b values = 50 and 400; mADC400-800 with b values = 400 and 800 s/mm2). Results The mean ADCs (× 10-3 mm2/s) were significantly higher in the rapid group (1.9 ± 0.44) than in the intermediate (1.7 ± 0.35, p = 0.046) or the slow groups (1.4 ± 0.34, p = 0.002). There were significant differences between the rapid and the slow groups in mADC50-400 (2.12 vs. 1.48; p = 0.008) and mADC400-800 (1.68 vs. 1.22, p = 0.010), and between the rapid and the intermediate groups in mADC50-400 (2.12 vs. 1.79, p = 0.049). Comparing mADC50-400 with mADC400-800, there was a significant difference only in the rapid group (p = 0.001). Conclusion Higher ADCs of rapidly-enhancing hemangiomas may be related to richer intralesional vascular perfusion. Also, the restricted diffusion may be attributed to the difference of structural characteristics of hemangioma.

Nam, Se Jin; Park, Kae Young; Chung, Jae-Joon; Kim, Joo Hee; Kim, Ki Whang



Contrast-enhanced sonography in the diagnosis of hepatic hemangiomas: atypical appearance due to the washout of microbubbles.  


Contrast-enhanced sonography (CEUS) examination permits identification of hemangioma of the liver in most cases. This method is particularly useful when the ultrasound pattern is atypical on standard grayscale examination. CEUS appearances suggestive of hemangioma are peripheral globular enhancement, progression of enhancement toward the center of the nodule, and persistence of enhancement in the late phase. We present seven cases of hemangioma, which were atypical on CEUS examination due to washout during the portal and late phases, resulting in a hypoenhanced appearance compared with the adjacent liver parenchyma. PMID:22610668

Giannetti, Andrea; Franci, Luca; Grechi, Cristina; Giangregorio, Francesco



Strawberry Hemangioma  


... to 70% but can also have adverse side effects. In the case of a severe hemangioma that does not respond to any medical therapy, radiation or surgical removal may be necessary. If you are worried about cosmetic appearance of the color later in your child's life, he/she may ...


Thyroid hemangioma.  


A case is presented of a fifty-six year old man with a thyroid hemangioma presenting as a neck mass with tracheal deviation and unilateral vocal cord paralysis. A standard thyroid scan yielded equivocal findings. The diagnosis was determined preoperatively by the use of a 99m-technetium angiogram that disclosed the vascular nature of the lesion. Subsequent arteriography demonstrated the main arterial supply of the mass to be from both inferior thyroid arteries. Operative removal of the mass was accomplished through a standard transverse cervical incision. Pathologic study revealed that the vascular tumor involved both the surrounding normal thyroid parenchyma and also a microfollicular adenoma. This case points out the value of utilizing all available diagnostic means in atypical cases of thyroid disease. PMID:1119698

Pickleman, J R; Lee, J F; Straus, F H; Paloyan, E



Vertebral Hemangioma (VH)  

Microsoft Academic Search

Hemangiomas are slowly growing benign vascular neoplasms derived from the endothelium of vessels. Subtypes include those with\\u000a an increase of capillaries (capillary hemangioma) and those associated with an enlargement of blood channels (cavernous hemangiomas)\\u000a as well as those of mixed type [12, 25, 89, 102, 110].

Reinhard Heyd; Michael Heinrich Seegenschmiedt


Unusual Severe Complication Following Transarterial Chemoembolization for Metastatic Malignant Melanoma: Giant Intrahepatic Cyst and Fatal Hepatic Failure  

SciTech Connect

We describe a 45-year-old male patient with malignant melanoma who underwent hepatic arterial chemoembolization due to liver metastases. Four months after the procedure, the patient developed a giant cystic cavity in the liver. Cytologic examination of the cystic fluid retention revealed necrotic tumor material. The fluid was drained by percutaneous catheter, but the patient developed hepatic failure. This case represents another rare complication of transarterial chemoembolization and shows that transarterial chemoembolization may have rare fatal complications.

Ataergin, Selmin, E-mail: [GATA (Gulhane) Faculty of Medicine Gn. Dr. Tevfik Saglam caddesi, Department of Medical Oncology and Bone Marrow Transplantation Unit (Turkey); Tasar, Mustafa [GATA (Gulhane) Faculty of Medicine, Department of Radiology (Turkey); Solchaga, Luis [Case Western Reserve University, Department of Blood and Marrow Transplant, Ireland Cancer Center, University Hospitals Case Medical Center (United States); Ozet, Ahmet; Arpaci, Fikret [GATA (Gulhane) Faculty of Medicine Gn. Dr. Tevfik Saglam caddesi, Department of Medical Oncology and Bone Marrow Transplantation Unit (Turkey)



Giant hepatic hydatid cyst with sub-fascial extension treated by open minimally invasive surgery: a case report  

PubMed Central

Introduction Hepatic hydatid disease can be successfully treated by a variety of modalities. Case Presentation We report a case of a 60 year old male with giant hepatic hydatid disease who presented with a huge cystic mass in the upper abdomen. Diagnosis was confirmed by serology, ultrasonography and CT scan. The patient was treated successfully by open minimally invasive surgery with minimum breaching of the peritoneal cavity using a laparoscopic trocar to evacuate the cyst. Conclusion The use of a laparoscopic trocar through a small abdominal incision in selected patients with hepatic hydatid disease with subfascial extension can be a safe, minimally-invasive option of treatment

Duttaroy, Dipesh D; Kacheriwala, Samir; Duttaroy, Bithika; Jagtap, Jitendra; Patel, Gunjan; Modi, Nikhil



Endoaortic stent grafting of a giant infected hepatic-celiac pseudoaneurysm.  


A 72-year-old man was admitted because of progressive right upper-abdominal distension and pain as well as concurrent remittent fever for 5 months. He had undergone a radical gastrectomy and catheter intubation in the common hepatic artery for chemotherapy 12 months before admission. The diagnosis of giant infected hepatic-celiac artery pseudoaneurysm was established. Coils embolotherapy was given in another hospital, but it failed. After admission, a computed tomographic aortogram showed a mass 10.3 x 8.5 x 8.1 cm in size in the right upper abdomen that originated from the common hepatic artery and the celiac artery. A celiac-super mesenteric artery (SMA) double catheter simultaneous digital subtraction angiography (DSA) further revealed that the entrance of the aneurysm opened directly from the abdominal aorta, the distance between the orifice of SMA and celiac axis was only 0.5 cm, and the diameter of the celiac trunk had been aneurysmally enlarged to 2.0 cm. A blood culture was positive for Bacillus pyocyaneus. After detailed discussion and preparation, a stent-graft complex was negotiated through the left femoral artery and deployed successfully into the abdominal aorta to seal the orifice of celiac trunk under the dynamic supervision of DSA. Completion angiography revealed that the hepatic-celiac pseudoaneurysm was completely excluded from aortic flow by the endoluminal stent-graft complex, while the SMA and renal arteries remained perfectly patent. The patient recovered uneventfully and was discharged without any residual symptoms. At a 5-year follow-up, the patient remained asymptomatic and was leading a normal life. PMID:16012466

Qu, Lefeng; Jing, Zaiping; Feng, Rui



Vasculogenesis in infantile hemangioma  

Microsoft Academic Search

Infantile hemangioma is a vascular tumor that occurs in 5–10% of infants of European descent. A defining feature of infantile\\u000a hemangioma is the dramatic growth and development into a disorganized mass of blood vessels. Subsequently, a slow spontaneous\\u000a involution begins around 1 year of age and continues for 4–6 years. The growth and involution of infantile hemangioma is very\\u000a different from other

Elisa Boscolo; Joyce Bischoff



Linear verrucous hemangioma.  


Verrucous hemangioma is a rare, vascular malformation. It is usually present at birth, but there is often a gradual increase in size and number with age; occasionally it presents in later adulthood. The lesions usually present as hyperkeratotic, bluish, and partly confluent papules and plaques. Linear verrucous hemangioma is an even more rare presentation described in very few published reports. We report a 30-year-old male patient with linear verrucous hemangioma who experienced a sudden increase in the size of his verrucous hemangioma during adulthood. PMID:19624993

Kaliyadan, Feroze; Dharmaratnam, A D; Jayasree, M G; Sreekanth, G



Giant cell hepatitis with autoimmune hemolytic anemia in a nine month old infant  

PubMed Central

Giant cell hepatitis (GCH) with autoimmune hemolytic anemia is a rare entity, limited to young children, with an unknown pathogenesis. We report the case of 9-mo old who presented with fever, diarrhea and jaundice four days before hospitalization. Physical examination found pallor, jaundice and hepatosplenomegaly. The laboratory workup showed serum total bilirubin at 101 ?mol/L, conjugated bilirubin at 84 ?mol/L, hemolytic anemia, thrombocytopenia and immunoglobulin G (IgG) and anti-C3d positive direct Coombs’ test. The antinuclear, anti-smooth muscle and liver kidney microsomes 1 non-organ specific autoantibodies, antiendomisium antibodies were negative. Serological assays for viral hepatitis B and C, cytomegalovirus, herpes simplex and Epstein Barr virus were negative. The association of acute liver failure, Evan’s syndrome, positive direct Coomb’s test of mixed type (IgG and C3) and the absence of organ and non-organ specific autoantibodies suggested the diagnosis of GCH. The diagnosis was confirmed by a needle liver biopsy. The patient was treated by corticosteroids, immunomodulatory therapy and azathioprine but died with septicemia.

Bouguila, Jihene; Mabrouk, Sameh; Tilouche, Samia; Bakir, Dajla; Trabelsi, Amel; Hmila, Amel; Boughammoura, Lamia



Vasculogenesis in Infantile Hemangioma  

PubMed Central

Infantile hemangioma is a vascular tumor that occurs in 5-10% of infants of European descent. A defining feature of infantile hemangioma is its dramatic growth and development into a disorganized mass of blood vessels. Subsequently, a slow spontaneous involution begins around one year of age and continues for four to six years. The growth and involution of infantile hemangioma is very different from other vascular tumors and vascular malformations, which do not regress and can occur at any time during childhood or adult life. Much has been learned from careful study of the tissue morphology and gene expression patterns during the life-cycle of hemangioma. Tissue explants and tumor-derived cell populations have provided further insight to unravel the cellular and molecular basis of infantile hemangioma. A multipotent progenitor cell capable of de novo blood vessel formation has been isolated from infantile hemangioma, which suggests that this common tumor of infancy, long considered to be a model for pathologic angiogenesis, may also represent pathologic vasculogenesis. Whether viewed as angiogenesis or vasculogenesis, infantile hemangioma represents a vascular perturbation during a critical period of post-natal growth, and as such provides a unique opportunity to decipher mechanisms of human vascular development.

Boscolo, Elisa; Bischoff, Joyce



Vasculogenesis in infantile hemangioma.  


Infantile hemangioma is a vascular tumor that occurs in 5-10% of infants of European descent. A defining feature of infantile hemangioma is the dramatic growth and development into a disorganized mass of blood vessels. Subsequently, a slow spontaneous involution begins around 1 year of age and continues for 4-6 years. The growth and involution of infantile hemangioma is very different from other vascular tumors and vascular malformations, which do not regress and can occur at any time during childhood or adult life. Much has been learned from careful study of the tissue morphology and gene expression patterns during the life-cycle of hemangioma. Tissue explants and tumor-derived cell populations have provided further insight to unravel the cellular and molecular basis of infantile hemangioma. A multipotent progenitor cell capable of de novo blood vessel formation has been isolated from infantile hemangioma, which suggests that this common tumor of infancy, long considered to be a model for pathologic angiogenesis, may also represent pathologic vasculogenesis. Whether viewed as angiogenesis or vasculogenesis, infantile hemangioma represents a vascular perturbation during a critical period of post-natal growth, and as such provides a unique opportunity to decipher mechanisms of human vascular development. PMID:19430954

Boscolo, Elisa; Bischoff, Joyce



Epithelioid hemangioma of bone  

Microsoft Academic Search

Although no specific radiographic appearance has emerged to date for the epithelioid subtype of hemangioma, these lesions\\u000a most typically exhibit well-defined osteolysis. Other relatively common features include surrounding sclerosis, cortical expansion\\u000a and cortical destruction. We present a case of epithelioid hemangioma of the spine with an unusual radiological appearance\\u000a which to our knowledge has not previously been reported: diffuse sclerosis

Stephen Ling; Mahvash Rafii; Michael Klein



Extended hemangioma from pharynx to esophagus that could be misdiagnosed as an esophageal varix on endoscopy.  


Giant hemangioma in the neck and head is an uncommon vascular neoplasm and has an unpredictable clinical behavior. We report a hemangioma that extended from the pharynx to the esophagus that could have been misdiagnosed as an esophageal varix. A 42-year-old man with dilated varices-like vessels on his esophagus that were incidentally detected by endoscopy was referred to our hospital for further evaluation. On re-examined endoscopy, multiple vascular dilatations were noted in the pharynx, expanding into the esophagogastric junction. These dilatations looked like esophageal varices that are found in patients with liver cirrhosis. There was no significant abnormality, including liver cirrhosis, on the abdomino-pelvic computed tomography scan. On the endoscopic esophageal biopsy, dilatedsubmucosal blood vessels were diagnosed as hemangioma. In consultation with an otorhinolaryngologist for evaluation of the risk of hemangioma, it was determined that the hemangioma was not dangerous to the patient as long as it did not cause hoarseness, dyspnea or dysphagia. We planned regular 6-month follow ups. We report a case of extended hemangioma that could possibly have been misdiagnosed as an esophageal varix on endoscopy. Even if head and neck hemangioma is uncommon, careful consideration during endoscopy is required to avoid the misdiagnosis of varices or hemangioma. PMID:24164602

Won, Jong Won; Lee, Hyun Woong; Yoon, Kyu Hyun; Yang, Suh Yoon; Moon, In Seok; Lee, Tae Jin



Hemangiomas of infancy  

Microsoft Academic Search

Hemangiomas of infancy are unique, benign, pediatric tumors of endothelial cells characterized by an initial phase of rapid proliferation, followed by slow involution, often leading to complete regression. Although most of these tumors are small and innocuous, some may be may be life- or function-threatening, or have associated structural congenital anomalies. Uncertainties regarding their diagnosis or management often prompt referral

Anna L. Bruckner; Ilona J. Frieden



Differential diagnosis of infantile hemangiomas.  


1.Compare and contrast infantile hemangiomas with other vascular anomalies that may be confused clinically.2.Describe the vascular anomalies classification system according to the International Society for the Study of Vascular Anomalies (ISSVA), highlighting the differences between vascular tumors, such as infantile hemangiomas, and vascular malformations.3.Briefly review associated signs or syndromes found in the context of certain vascular anomalies.Infantile hemangiomas are the most common benign vascular tumor in infancy but may mimic many other types of vascular anomalies. In many cases, the appearance, time of onset, growth pattern, and consistency of infantile hemangiomas make the diagnosis straightforward (see "Pathogenesis of Infantile Hemangiomas" on p. 321). However, many other vascular lesions can appear quite similar to infantile hemangiomas, especially early in life, and at times this makes the correct diagnosis challenging. PMID:22881414

Perman, Marissa J; Castelo-Soccio, Leslie; Jen, Melinda



Case report: Periorbital intraosseous hemangiomas  

PubMed Central

Hemangiomas are hamartomatous proliferation of vessels. Intraosseous hemangiomas of the facial bones are rare and most commonly involve the zygoma, maxilla, mandible, and the nasal bones. A “sunburst” pattern is a typical appearance on CT scan and MRI and therefore a biopsy is not always necessary. Surgery is usually performed in symptomatic cases. The authors describe five typical periorbital intraosseous hemangiomas with a brief review of literature.

Goncalves, Fabricio Guimaraes; Rojas, Juan Pablo Ovalle; Hanagandi, Prasad Baladev; Valente, Rodolfo; Torres, Carlos Ignacio; Chankwosky, Jeffrey; DelCardio-O'Donovan, Raquel



Cavernous Hemangioma of the Tongue  

PubMed Central

Hemangioma is a benign tumor of dilated blood vessels. It is most commonly seen in the head and neck region and rarely in the oral cavity. Hemangiomas in the oral cavity are always of clinical importance and require appropriate treatment. We report here a case of a 34-year-old female patient with a swelling on the lateral surface of tongue which did not respond to the sclerosing agent and was finally confirmed as cavernous hemangioma on histological evaluation.

Kripal, Krishna; Rajan, Senthil; Ropak, Beena; Jayanti, Ipsita



Distinction between hemangioma of the liver and hepatocellular carcinoma: value of labeled RBC-SPECT scanning  

Microsoft Academic Search

The role of adding single-photon emission CT (SPECT) to \\/sup 99m\\/Tc-labeled RBC imaging of the liver was evaluated by specifically focusing on the differentiation between hepatic hemangioma and hepatocellular carcinoma. Planar RBC imaging followed by blood-pool SPECT scanning was performed in 77 patients with a total of 108 hemangiomas and in 29 patients with a total of 46 hepatocellular carcinomas.

Masatoshi Kudo; Katsuji Ikekubo; Kazutaka Yamamoto; Y. Ibuki; M. Hino; S. Tomita; H. Komori; A. Orino; A. Todo



Dumbbell-Shaped Epidural Capillary Hemangioma  

Microsoft Academic Search

Summary: We report a case of a purely epidural capillary hemangioma of the thoracic spine with foraminal exten- sion. Epidural hemangiomas are rare; only a few cases of dumbbell-shaped ones have been reported, and all were cavernous. MR imaging showed characteristic findings of a capillary hemangioma, which are also consistent with other epidural lesions such as neuromas or meningiomas. Hemangiomas

Bruno Badinand; Christophe Morel; Nicolas Kopp; A. Tran; Francois Cotton


Use of propranolol in treating hemangiomas  

PubMed Central

Abstract Question I see many children with infantile hemangiomas and have read about new therapeutic options such as propranolol. Is this medication effective and safe for treating hemangiomas in children? Answer Most infantile hemangiomas resolve spontaneously without any need for therapy. In many case series, propranolol has been shown to be effective and safe in treating hemangiomas that cause complications. Further studies are required to determine the optimal dose and duration of propranolol treatment for problematic hemangiomas.

Shayan, Yasaman R.; Prendiville, Julie S.; Goldman, Ran D.



[Synovial hemangioma within Hoffa's fat pad as the cause of anterior knee pain. 2 cases within a family and review of the literature].  


An 18 years old man and his younger sister suffered from anterior knee pain. Cause is a soft tissue tumor located within Hoffa's fat pad however in both cases. The tumor has been excised and the histological examination demonstrated the diagnosis synovial hemangioma. A literature search shows that synovial hemangiomas are rare soft tissue tumors. They mainly involve the knee joint. Mean age is the second decade of life and most authors observed severe degenerative changes in the involved knee joint. There are no reports about familiar accumulation within the literature. Familiar accumulation of synovial hemangiomas however have been described for cerebral, skin and hepatic manifestations but not for synovial hemangiomas. PMID:11051028

Petersen, W; Rafii, M; Ellwanger, S; Laprell, H


Infantile hemangiomas: A review  

PubMed Central

Infantile hemangiomas (IH) are the most common eyelid and orbital tumors of childhood. Although they are considered benign lesions that have a generally self-limited course, in the periocular region, they have the potential to cause amblyopia, strabismus, and severe disfigurement. The decision for treatment can be a source of anxiety for patients, parents, and physicians alike. There are numerous treatment modalities, including emerging therapies that may make treatment safer and more effective than ever before. This review discusses our current understanding of this disease, its management, and future therapies.

Callahan, Alison B.; Yoon, Michael K.



Progenitor cells in infantile hemangioma  

PubMed Central

Infantile hemangioma is a vascular tumor that occurs in 5–10% of infants of European descent. A hallmark of infantile hemangioma is its lifecycle, which is divided into three stages. The proliferating phase spans the first year of postnatal life, and is characterized by cellular masses without a defined vascular architecture as well as nascent blood vessels with red blood cells evident within the lumenal space. The involuting phase begins around one year of age and continues for 3–5 years. Proliferation slows or stops in this phase, and histology shows that the blood vessel architecture becomes more obvious and vessel size is enlarged. The involuted phase is reached by 5–8 years of age, at which point blood vessels are replaced with a fibrofatty residuum and capillary-sized channels. The growth and involution life-cycle of infantile hemangioma is very different from other vascular tumors and vascular malformations, which do not regress and can occur at any time during childhood or adult life. Many laboratories have reported on the endothelial characteristics of the cellular masses that are prominent in the proliferating phase of infantile hemangioma, as well as their immature appearance. These studies, along with isolation and characterization of hemangioma-derived cell populations with progenitor cell properties have lead to an emerging hypothesis that hemangioma is caused by an abnormal or delayed differentiation of mesodermal progenitor cells into the disorganized mass of blood vessels. Here we discuss the literature that support this emerging hypothesis.

Bischoff, Joyce



Chorionic villus sampling and hemangiomas.  


Chorionic villus sampling (CVS) is a widely used and safe method of prenatal diagnosis. In the 1990s, concerns were raised at several medical centers that there was an increased risk to the exposed fetus for the occurrence of limb deficiencies, hemangiomas, and other vascular disruption defects. The risk was greater when the procedure was performed earlier in pregnancy, such as 8 or 9 weeks of gestation. The postulated mechanisms for the fetal injury included blood loss, hypoperfusion, hypoxia, endothelial cell damage, hemorrhage, and tissue loss. The effect was most common in tissues with end arteries, such as digits, tongue, brain stem, and intestine. The associated hemangiomas were infantile hemangiomas. They were more common on the head, neck, and thorax and more often multiple in infants exposed to CVS. One postulated mechanism for the occurrence of these hemangiomas is embolization of angioblasts or endothelial cells from the placenta to the fetal skin. A question to be answered is whether the infantile hemangiomas in children exposed to CVS differ in immunohistologic characteristics from similar hemangiomas in children not exposed to CVS during pregnancy. PMID:19218861

Holmes, Lewis B





... body digest food, store energy and remove poisons. Hepatitis is a swelling of the liver that makes ... or to cancer. Viruses cause most cases of hepatitis. The type of hepatitis is named for the ...


Infantile Hemangiomas Masquerading as Other Periocular Disorders  

PubMed Central

Periocular tumors are common in infancy. The most common periocular tumors are capillary hemangiomas, which are present in 1-2% of newborns and develop in 10%–12% of children by the age of 1 year old. Deep capillary hemangiomas may be more challenging to diagnose than superficial capillary hemangiomas and can be confused with other orbital lesions. Deep orbital hemangiomas can mimic teratoma, lymphangioma, rhabdomyosarcoma, metastatic neuroblastoma, and granulocytic sarcoma. In this paper, we describe 2 pediatric cases where previously diagnosed dermoid cyst and dacrocystocele were found to be capillary hemangiomas upon biopsy. Approaches to distinguish capillary hemangiomas from other periocular tumors are further discussed. To our knowledge, this is the first case report of periocular hemangiomas imitating a dermoid cyst and a dacrocystocele. These cases emphasize the importance of including infantile hemangiomas in the differential diagnosis of subcutaneous periocular abnormalities.

Hsu, Jennifer; Mohney, Brian G.



Proton beam irradiation of choroidal hemangiomas  

Microsoft Academic Search

PURPOSE: To present a large series of choroidal hemangiomas treated with proton beam irradiation and to describe the treatment outcomes.METHODS: We treated 54 eyes of 53 patients with choroidal hemangioma. The lesions consisted of 48 circumscribed hemangiomas and six diffuse hemangiomas in patients with Sturge-Weber syndrome. The total applied dose was 27.3 Gy in four eyes, 22.7 Gy in three

Leonidas Zografos; Emmanuel Egger; Ludmila Bercher; Line Chamot; Gudrun Munkel



Spinal cord compression due to vertebral hemangioma.  


This article presents a case of multiple vertebral hemangiomas in a 58-year-old man with pain in the dorsal region and bilateral progressive foot numbness. Magnetic resonance imaging revealed multiple vertebral hemangiomas. One hemangioma at the T7 level demonstrated epidural extension, causing spinal cord compression. After treatment with radiotherapy, the patient's symptoms improved significantly. PMID:19292199

Aksu, Gorkem; Fayda, Merdan; Saynak, Mert; Karadeniz, Ahmet



Angiographic features of rapidly involuting congenital hemangioma (RICH)  

Microsoft Academic Search

Rapidly involuting congenital hemangioma (RICH) is a recently recognized entity in which the vascular tumor is fully developed at birth and undergoes rapid involution. Angiographic findings in two infants with congenital hemangioma are reported and compared with a more common postnatal infantile hemangioma and a congenital infantile fibrosarcoma. Congenital hemangiomas differed from infantile hemangiomas angiographically by inhomogeneous parenchymal staining, large

Orhan Konez; Patricia E. Burrows; John B. Mulliken; Steven J. Fishman; Harry P. Kozakewich



Mixed Capillary Venous Retroperitoneal Hemangioma  

PubMed Central

We report a case of mixed capillary venous hemangioma of the retroperitoneum in a 61-year-old man. Abdominal ultrasonography showed a mass to be hypoechoic with increased flow in color Doppler imaging. Dynamic contrast-enhanced computed tomography revealed a centripetal filling-in of the mass, located anterior to the left psoas muscle at the level of sacroiliac joint. On the basis of imaging features, preoperative diagnosis of hemangioma was considered and the mass was excised by laparoscopic method. Immunohistochemical studies were strongly positive for CD31 and CD34, and negative for calretinin, EMA, WT1, HMB45, Ki67, synaptophysin, and lymphatic endothelial cell marker D2–40. Histologically, the neoplasm was diagnosed as mixed capillary venous hemangioma.

Godar, Mohit; Yuan, Qinghai; Shakya, Rukeshman; Xia, Yang



Intrapericardial Hemangioma: A Case Report  

PubMed Central

Hemangiomas of the pericardium are very rare primary pericardial tumours. Very few cases of pericardial hemangioma have been reported in the literature till date. We are reporting a case of a 40 years old male who presented with the complaints of chest discomfort and palpitation on exertion, of 3 months duration. ECHO and Colour Doppler ECHO which were done, revealed a large heterogeneous mass which measured 7.6 × 7.1cms, which was possibly attached to the roof and the anterior surface of the left atria, which was possibly a myxoma. Based on the radiological findings, a diagnosis of left atrial myxoma was considered. However, intra operatively, an encapsulated mass was seen within the pericardium, which was successfully excised and sent for histopathology. The histopathological examination revealed an intrapericardial hemangioma. This case has been reported on account of its extreme rarity.

Gupta, Nalini



Intrapericardial hemangioma: a case report.  


Hemangiomas of the pericardium are very rare primary pericardial tumours. Very few cases of pericardial hemangioma have been reported in the literature till date. We are reporting a case of a 40 years old male who presented with the complaints of chest discomfort and palpitation on exertion, of 3 months duration. ECHO and Colour Doppler ECHO which were done, revealed a large heterogeneous mass which measured 7.6 × 7.1cms, which was possibly attached to the roof and the anterior surface of the left atria, which was possibly a myxoma. Based on the radiological findings, a diagnosis of left atrial myxoma was considered. However, intra operatively, an encapsulated mass was seen within the pericardium, which was successfully excised and sent for histopathology. The histopathological examination revealed an intrapericardial hemangioma. This case has been reported on account of its extreme rarity. PMID:23449754

Gupta, Nalini



Clinical Significance of Placental Hemangiomas.  

National Technical Information Service (NTIS)

A clinical and pathologic study of 38 hemangiomas of the placenta was carried out, with emphasis on the presence of other complications of pregnancy. One or more complications were found in 22 of the 38 patients; these included premature delivery, hydramn...

L. A. Asadourian H. B. Taylor



Parathyroid hemangioma: A report of two cases  

Microsoft Academic Search

Two cases of intraparathyroid hemangioma, associated with hyperparathyroidism, are reported. The first case showed a typical\\u000a capillary hemangioma morphology with small branching vascular channels, almost completely replacing the gland’s architecture.\\u000a The second case was a 2-mm cavernous hemangioma associated with glandular hyperplasia. This is, to our knowledge, the first\\u000a time that this type of lesion is described.

Maria J. Merino; Rodrigo Chuaqui; Pedro Fernandez



Endothelial progenitor cells in infantile hemangioma  

Microsoft Academic Search

Infantile hemangioma is an endothelial tumor that grows rapidly after birth but slowly regresses during early childhood. Initial proliferation of hemangioma is char- acterized by clonal expansion of endothe- lial cells (ECs) and neovascularization. Here, we demonstrated mRNA encoding CD133-2, an important marker for endo- thelial progenitor cells (EPCs), predomi- nantly in proliferating but not involuting or involuted hemangioma. Progenitor

Ying Yu; Alan F. Flint; John B. Mulliken; June K. Wu; Joyce Bischoff



Hemangioma Is Associated with Atopic Disease.  


Objective. To determine if atopic disease is associated with infantile hemangioma.Study Design. Case control study.Setting. State of Utah inpatient and outpatient records obtained from the Department of Health, Intermountain Healthcare medical records, and the University of Utah Health Care medical records using the Utah Population Database.Subjects. Patients given an International Classification of Diseases, Ninth Revision diagnosis of hemangioma prior to age 5 years, from 1991 to 2009.Methods. Allergy, asthma, and eczema rates in the hemangioma cohort compared to randomly matched controls using logistic regression analysis.Results. The authors identified 2063 patients in the hemangioma group. The overall odds ratio of atopic disease in patients diagnosed with hemangioma was 1.67 compared to the control group (P < .0001). In the hemangioma cohort, the authors found a 36% increased risk of allergies (P < .0001), 67% increased risk of asthma (P < 4e-12), and 82% increased risk of eczema (P < 2e-16).Conclusion. This study indicates that allergy, asthma, and eczema are positively associated with hemangioma. Eczema was most strongly associated with hemangioma, with a nearly 2-fold increased risk. Understanding the relationship between atopic disease and infantile hemangioma may elucidate the pathophysiology of each and ultimately lead to better treatment options. PMID:22031593

Grimmer, J Fredrik; Williams, Marc S; Pimentel, Richard; Mineau, Geraldine; Wood, Grant M; Bayrak-Toydemir, Pinar; Stevenson, David A



Aggressive hemangioma of the thoracic spine  

PubMed Central

Vertebral hemangiomas are common lesions and usually considered benign. A rare subset of them, however, are characterized by extra-osseous extension, bone expansion, disturbance of blood flow, and occasionally compression fractures and thereby referred to as aggressive hemangiomas. We present a case of a 67-year-old woman with progressive paraplegia and an infiltrative mass of T4 vertebra causing mass effect on the spinal cord. Multiple conventional imaging modalities were utilized to suggest the diagnosis of aggressive hemangioma. Final pathologic diagnosis after decompressive surgery confirmed the diagnosis of an osseous hemangioma.

Schrock, Wesley B.; Wetzel, Raun J.; Tanner, Stephanie C.; Khan, Majid A.



The role of hepatic myofibroblasts in liver cirrhosis in fallow deer (Dama dama) naturally infected with giant liver fluke (Fascioloides magna)  

PubMed Central

Background This paper describes liver cirrhosis in 35 fallow deer infected with the giant liver fluke, as well as the distribution, origin, and role of myofibroblasts in its development. Results In liver of infected deer, stripes of connective tissue are wound around groups of degenerated and regenerated liver lobuli. In the connective tissue, lymphocytes and macrophages which often contain parasite hematin are also present. The walls of the bile ducts are thickened, the epithelium multiplied with mucous metaplasia, and desquamated cells, parasite eggs and brown pigment are present in their lumen. In the livers with cirrhosis, immunopositivity to ?-SMA and desmin was observed in cells in portal and septal spaces, at the edge between fibrotic septa and the surrounding parenchyma and in perisinusoidal spaces. These cells vary in size, they are round, oval, spindle-shaped or irregular in shape, similar to vascular smooth muscle cells. The derangement of epithelial-mesenchymal interactions detected in chronic cholangiopathies is most probably the pro-fibrogenic mechanism in liver cirrhosis of fallow deer (Dama dama) infected with the giant liver fluke (Fascioloides magna). Conclusion Myofibroblasts, especially hepatic stellate cells (HSCs), play an important role in the synthesis of extracellular matrix components in the development of parasitic fibrosis and cirrhosis in the liver of fallow deer.



Cavernous hemangioma of the parietal bone  

PubMed Central

Patient: Male, 38 Final Diagnosis: Cavernous hemangioma Symptoms: Headache • parietal mass Medication: — Clinical Procedure: — Specialty: Neurosurgery Objective: A rare disease Background: Bone hemangioma is a vascular hemartoma of bone structures. In general, this pathology is detected on incidentally investigated patients’ films. Bone hemangioma is most commonly seen in 4th decade of life and the male/female ratio is 1/1.5. The locations of these lesions are commonly long bones of the vertebral column and the skull. Primary bone hemangiomas constitute less than 1% of all bone tumors, and they are seen at 0.2% in the calvarial region. Case Report: Cases with this pathology are seen on incidental radiological evaluations. We report the case of a 38-year-old man with localized headache and a palpable mass in the left parietal region, admitted and operated on after cranial CT and MRI. Pathology investigation revealed a cavernous hemangioma. Conclusions: We suspected that in our case head trauma may have been the cause of cavernous hemangioma in the calvarial region, because cavernous hemangiomas are rarely located there. Localized headache and minor discomfort can be seen with this pathology. The best treatment for cavernous hemangiomas is the removal of the mass within the limits of safe surgery.

Atc?, Ibrahim Burak; Albayrak, Serdal; Y?lmaz, Nejat; Ucler, Necati; Durdag, Emre; Ayden, Omer; Kara, Deniz; Bitlisli, Hulya; Cihangiroglu, Gulcin



Potential complications of segmental hemangiomas of infancy  

Microsoft Academic Search

Although the majority of hemangiomas of infancy can be expected to follow a benign course, a significant subset may result in serious complications. Recently, hemangiomas of segmental morphology, or those which are large, plaque-like, and patterned in distribution, have been recognized as important markers for potential complications. PHACE syndrome represents the best known example of the variety of problems that

Denise W Metry



An Oncocytic Variant of Intraductal Papillary Neoplasm of the Bile Duct that Formed a Giant Hepatic Cyst  

PubMed Central

Intraductal papillary neoplasms of the bile duct (IPNB) is the collective term used to refer to papillary bile duct tumors, mucin producing bile duct tumors, and cystic bile duct tumors. Pathologically, these tumors may be considered a highly differentiated adenocarcinoma or a tumor of borderline malignant potential. IPNB is classified into one of four variants based on cell differentiation. The rarest, oncocytic, is characterized by oxyphilic granular cytoplasm and no mucous cell differentiation. The patient, a 59-year old man, was admitted with a complaint of abdominal fullness and a 30×25 cm cystic mass in the right hepatic lobe demonstrated on computed tomography (CT). The mass had no malignant features on CT or magnetic resonance imaging; however, a portion was FDG avid on 18F-fluorodeoxyglucose positron emission tomography scan (FDG-PET). A fenestration operation was performed for the presumed diagnosis of a hepatic cyst. Pathological examination of the cyst contents demonstrated some atypical cells suspicious for malignancy. After eight months of observation, abnormal FDG uptake was again observed at the residual cyst. A partial hepatectomy was performed to excise the cyst. Pathological examination demonstrated adenocarcinoma in situ derived from an oncocytic IPNB variant. Following the resection, the patient remained disease free for 40 months. This is an extremely rare case of an oncocytic variant of IPNB that was difficult to distinguish clinically from a solitary hepatic cyst.

Watanabe, Akira; Suzuki, Hideki; Kubo, Norio; Araki, Kenichiro; Kobayashi, Tsutomu; Sasaki, Shigeru; Wada, Wataru; Arai, Hideo; Sakamoto, Kazuha; Sakurai, Shinji; Kuwano, Hiroyuki



Pathogenesis of human hemangiosarcomas and hemangiomas.  


Hemangiosarcomas are uncommon aggressive vascular tumors that have recently become the focus of attention because several chemicals and pharmaceuticals increase their incidence in mice. The relevance of these mouse vascular tumors to humans is unclear. In the present study, we semiquantitatively evaluated the expression profiles of hematopoietic stem cell markers (CD117 [c-kit], CD133, CD34, and CD45), endothelial cell markers (vascular endothelial growth factor receptor 2, CD31, and factor VIII-related antigen), and a myeloid lineage cell marker (CD14) in human hemangiosarcoma (n = 12) and hemangioma (n = 10) specimens using immunohistochemistry. CD133 was completely negative in almost all cases of hemangiosarcomas and hemangiomas. Most hemangiosarcomas, but not hemangiomas, stained for CD117 and CD45. Both groups diffusely expressed CD34, vascular endothelial growth factor receptor 2, and factor VIII-related antigen; however, hemangiomas had more intense and diffuse CD34 and factor VIII-related antigen expression compared with hemangiosarcomas, whereas CD31 was positive in all hemangiosarcomas but only half of the hemangiomas. CD14 staining was negative in most hemangiosarcoma and hemangioma cases. Our results indicate that multipotential bone marrow-derived hematopoietic stem cells or early endothelial progenitor cells (EPCs) expressing CD117, CD34, and CD45 are involved in hemangiosarcoma formation, whereas hemangiomas originate from late EPCs or differentiated endothelial cells, which have lost the expression of most hematopoietic stem cell markers. This contrasts with our previous results that demonstrated that both hemangiosarcomas and hemangiomas in mice may be derived from early EPCs that are not completely differentiated. PMID:24054722

Liu, Liping; Kakiuchi-Kiyota, Satoko; Arnold, Lora L; Johansson, Sonny L; Wert, David; Cohen, Samuel M



Facial nerve hemangioma: a case report.  


Although hemangiomas are relatively common in the head and neck, those that originate in the facial nerve are extremely rare. These benign tumors have the potential to compress or invade the adjacent facial nerve and thereby produce facial paralysis and other associated symptoms. We present a case of facial nerve hemangioma in a 15-year-old girl that initially manifested as unilateral facial weakness. We also discuss the diagnostic imaging and management options. PMID:23780592

Wu, Edward C; Rothholtz, Vanessa S; Zardouz, Shawn; Lee, Alice D; Djalilian, Hamid R



Spinal epidural hemangioma related to pregnancy  

Microsoft Academic Search

We report the case of a 39-year-old woman with adolescent idiopathic scoliosis presenting with myelopathy secondary to a spinal\\u000a epidural hemangioma. MRI showed an epidural soft tissue mass within the spinal canal between T5 and T9 with severe spinal\\u000a cord compression. Symptoms had a temporal relationship to her pregnancy. Surgical removal of the epidural hemangioma rapidly\\u000a relieved her symptoms and

Gary S. Shapiro; Peter J. Millett; Edward F. DiCarlo; Douglas N. Mintz; Francis W Gamache; Bernard A. Rawlins



Cardiac hemangioma. A case report and discussion.  

PubMed Central

A cardiac hemangioma is a rare form of primary cardiac tumor. To our knowledge, only 34 cases of cardiac hemangioma have been discussed in the literature at the time of this writing. We report the case of a patient who presented with 1 episode of exertional dyspnea. The medical history, physical exam, work-up, surgical approach, and outcome are discussed. Other published reports on this topic are also reviewed. Images

Pigato, J B; Subramanian, V A; McCaba, J C



Multifocal photodynamic therapy for diffuse choroidal hemangioma  

PubMed Central

Background A choroidal hemangioma is an uncommon benign vascular tumor of the choroid that can be either circumscribed or diffuse. In our experience, diffuse choroidal hemangiomas in Asian patients often require multiple photodynamic therapy (PDT) treatment sessions. Methods We here provide a case report of a 7-year-old boy with Sturge–Weber syndrome who presented with diffuse choroidal hemangioma in the left eye. Five sessions of PDT treatment were required over a period of 1 year and a final optical coherence tomogram 3 months later revealed resolution of subretinal fluid and the choroidal hemangioma. Results Final visual acuity was 20/100 in the left eye with resolution of subretinal fluid. This case report illustrates that a single application of PDT using standard published parameters was insufficient to achieve the destruction of the enlarged vessels. This experience is similar to previous Chinese reports on circumscribed choroidal hemangiomas. The decision for repeat treatment was based on subretinal fluid recurrence, rather than complete tumor regression. Conclusion Our case report supports previous suggestions that larger dilated vessels in the vascular network of a choroidal hemangioma might affect the efficacy and selectivity of PDT in treating the eyes of Asian patients – which may explain the need for multiple treatments.

Ang, Marcus; Lee, Shu-Yen





... 21, 2013. Usatine RP, et al. The Color Atlas of Family Medicine. New York, NY.: The McGraw- ... E-newsletter Blogs Podcasts Slide shows Videos Site map Reprint permissions Interest-Based Ads Find Mayo Clinic ...


Angiographic features of rapidly involuting congenital hemangioma (RICH).  


Rapidly involuting congenital hemangioma (RICH) is a recently recognized entity in which the vascular tumor is fully developed at birth and undergoes rapid involution. Angiographic findings in two infants with congenital hemangioma are reported and compared with a more common postnatal infantile hemangioma and a congenital infantile fibrosarcoma. Congenital hemangiomas differed from infantile hemangiomas angiographically by inhomogeneous parenchymal staining, large and irregular feeding arteries in disorganized patterns, arterial aneurysms, direct arteriovenous shunts, and intravascular thrombi. Both infants had clinical evidence of a high-output cardiac failure and intralesional bleeding. This congenital high-flow vascular tumor is difficult to distinguish angiographically from arteriovenous malformation and congenital infantile fibrosarcoma. PMID:12497230

Konez, Orhan; Burrows, Patricia E; Mulliken, John B; Fishman, Steven J; Kozakewich, Harry P W



Surgical treatment of hemangiomas of the nose.  


The approach to a rapidly growing vascular tumor is determined by a number of objective and subjective factors. As a rule, treatment of a hemangioma in an infant is usually delayed, in the expectation that involution will be complete. While most hemangiomas are harmless vascular marks, some may grow to become large, infiltrating masses. Local factors that influence treatment decision making include volume, ulceration, secondary infection, and bleeding of the tumor. Hemangiomas situated on the nose are distinguished from other locations by a few but important aspects and may demand a more aggressive position from the surgeon. An important consideration is the potential for aplasia of the delicate nasal cartilages that are undergoing development, due to the mass effect of the tumor. Nasal tip hemangiomas are slow to regress, and contour deformities result from the fibrofatty tissue that invariably remains even after total involution. More importantly, hemangiomas of the nasal region are particularly prone to causing great social distress to the parents, who will request prompt treatment for such a visible, deforming lesion. A definite solution that ensures removal of affected tissue and preservation of anatomy seems to be the best treatment for these tumors. In this article, the experience of the senior author (IP) in treating hemangiomas located on the nose is reviewed. The elliptical midline incision over the nasal dorsum described in the text was developed to address three important aspects: an expedient procedure to treat a highly disfiguring disease; an open access to allow for complete resection and, at the same time, allow for the correction of underlying cartilaginous disruption; and placement of a scar in an anatomic location proven to be very satisfactory aesthetically, permitting access for secondary procedures for better definition of nasal contour. Careful patient selection for this surgical procedure is emphasized. PMID:8792967

Pitanguy, I; Machado, B H; Radwanski, H N; Amorim, N F



Imaging characteristics of cavernous sinus cavernous hemangiomas.  


Cavernous hemangiomas occur rarely in the cavernous sinus and are difficult to diagnose preoperatively. The imaging of these lesions resembles other benign paracavernous lesions such as schwannomas and meningiomas. Profuse intraoperative bleeding may be encountered during surgical resection of these lesions. A preoperative diagnosis is therefore important to alert the surgeon. We report on the imaging characteristics of two different histopathological types of cavernous sinus cavernous hemangiomas and the use of contrast-enhanced MRI, diffusion-weighted MRI and magnetic resonance spectroscopy in the differential diagnosis of these lesions. PMID:24029085

Yadav, R R; Boruah, D K; Yadav, G; Pandey, R; Phadke, R V



Cavernous Hemangioma of Maxillary Sinus: Case Report  

Microsoft Academic Search

ACM, 33 years, male, whith history of epistaxis for 02 weeks. After diagnosis procedures he did refer to surgery that have a diagnosis of cavernous hemangioma of maxilar sinus. He get success whith excelent evolution. Conclusion: The treatment not always is necessary to depend on the histological type. When is need, the treatment is surgical. We report a case of

Pablo Pinillos Marambaia; Otávio Marambaia dos Santos; Amaury de Machado Gomes; Tiago Ferraz Melo; Ticiana Rocha Francisco; André Henrique Araújo


Masson's hemangioma: A rare intraoral presentation  

PubMed Central

An otherwise healthy 19-year-old female patient had painless swelling in her left buccal mucosa. No precipitating factors were identified. Pathological analysis demonstrated the mass to be a Masson's hemangioma, a papillary proliferation of thin-walled capillaries intimately associated with thrombus. A very rare tumor occurring in oral cavity with only 80 cases being published in literature until date.

Narwal, Anjali; Sen, Rajeev; Singh, Virender; Gupta, Ambika



Essentials of surgical treatment for intramasseteric hemangioma  

Microsoft Academic Search

Although rare, surgical treatment may become necessary for patients with intramasseteric hemangiomas. Possible bleeding, neural injury or postoperative dysfunction are factors limiting surgical approaches. We present the following surgical highpoints for tumors involving the masseter muscles. These include careful preoperative planning with computed tomography and magnetic resonance imaging, as well as a surgical approach that provides adequate exposure for optimal

K. Ichimura; K. Nibu; T. Tanaka



Hemangiomas of the cecum. Colonoscopic diagnosis and therapy.  


Five cases of hemangiomas of the cecum and gastrointestinal bleeding are presented. All were demonstrated by colonscopy after more conventional diagnostic methods failed. The hemangiomas were bright red, flat lesions clearly seen through the colonscope. They were successfully treated by electrocoagulation. All patients in this series had some type of associated cardiac or vascular disease. These patients may represent a syndrome of gastrointestinal blood loss of obscure cause, hemangiomas of the cecum, and cardiovascular disease. PMID:1086811

Rogers, H G; Adler, F



GI-Associated Hemangiomas and Vascular Malformations  

PubMed Central

Hemangiomas and vascular malformations of the gastrointestinal tract, rare clinical entities, present as overt or occult bleeding. They can be distributed throughout the intestinal digestive system, or present as a singular cavernous hemangioma or malformation, which is often located in the rectosigmoid region. Misdiagnosis is common despite characteristic radiographic features such as radiolucent phleboliths on plain film imaging and a purplish nodule on endoscopy. Adjunctive imaging such as computed tomography and magnetic resonance imaging are suggested as there is potential for local invasion. Endorectal ultrasound with Doppler has also been found to be useful in some instances. Surgical resection is the mainstay of treatment, with an emphasis on sphincter preservation. Nonsurgical endoscopic treatment with banding and sclerotherapy has been reported with success, especially in instances where an extensive resection is not feasible.

Yoo, Stephen



Solitary skeletal hemangioma of the extremities  

Microsoft Academic Search

Objective. To report the clinicopathologic features of solitary skeletal hemangioma of the extremities and to review previous cases\\u000a in the English language medical literature. Patients. In addition to five of our own cases, 34 literature cases with substantial and 75 with partial clinicopathologic information\\u000a were found. Results. Our patients, three men and two women, ranged in age from 37 to

Zahid Kaleem; Michael Kyriakos; William G. Totty



Symptomatic vertebral hemangioma related to pregnancy  

Microsoft Academic Search

In this paper, we report a case of vertebral hemangioma during pregnancy in a 21-year-old woman presenting with paraparesis\\u000a of rapid onset. An emergency MRI scan of the dorsal spine showed a lesion of the ninth thoracic vertebra with extradural extension\\u000a and marked spinal cord compression. A cesarean section was done, and this was followed by emergent laminectomy. Her symptoms

Murvet Yuksel; K. Zafer Yuksel; Deniz Tuncel; Beyazit Zencirci; Sevgi Bakaris



Mimicry of lyme arthritis by synovial hemangioma  

Microsoft Academic Search

To report on the differential diagnosis of lyme arthritis and synovial hemangioma due to similar clinical and radiological\\u000a signs and symptoms. A 15-year-old boy presented at the age of 9 with recurrent rather painless swelling of the right knee.\\u000a Altogether four episodes lasting for 1–2 weeks each occurred over a period of 18 months before medical advice was sought.\\u000a Physical examination revealed

Toni Hospach; M. Langendörfer; T. V. Kalle; F. Tewald; T. Wirth; G. E. Dannecker


Atlas of hepatic tumors and focal lesions: Arteriographic and tomographic diagnosis  

SciTech Connect

This book describes the diagnosis of liver tumors. Topics considered include general considerations, hepatocellular carcinoma, hepatoblastoma, cholangiocarcinoma, mesenchyomoma, sarcoma, hemangioma, hepatic cell adenoma, focal nodular hyperlasia (FNH), hamartoma, echinococcus cyst, abscess, AV fistula, hepatic artery aneurysm, metastatic carcinoma-colon, metastatic cholangiocarcinoma, metastatic melanoma, metastatic merkel cell and extrahepatic tumor.

Gutierrez, O.; Schwartz, S.I.



Cavernous hemangioma of the skull: 3 case reports  

Microsoft Academic Search

BackgroundIntraosseous cavernous hemangiomas of the bone are uncommon tumors, accounting for 0.7% to 1% of all bone neoplasms. The vertebral column is most often affected, followed by the skull. Calvarial cavernous hemangioma is rare, comprising about 0.2% of all benign neoplasms of the skull.

Okacha Naama; Miloudi Gazzaz; Ali Akhaddar; Adil Belhachmi; Abad Asri; Brahim Elmostarchid; Abderrahman Elbouzidi; Bouchaib Kadiri; Mohamed Boucetta



Adult Pancreatic Hemangioma: Case Report and Literature Review  

PubMed Central

We report an adult pancreatic hemangioma diagnosed on pathological specimen review following pylorus preserving pancreaticoduodenectomy for a symptomatic cystic mass in the head of the pancreas. Eight cases of adult pancreatic hemangioma have been reported in literature since 1939. Presenting symptoms, radiographic diagnosis, pathologic characteristics, and treatment of adult pancreatic hemagiomas are discussed following review of all published cases.

Mundinger, Gerhard S.; Gust, Shannon; Micchelli, Shien T.; Fishman, Elliot K.; Hruban, Ralph H.; Wolfgang, Christopher L.



Intraventricular Cavernous Hemangiomas Located at the Foramen of Monro  

PubMed Central

Intraventricular cavernous hemangiomas are uncommon. Among them, those occurred at the foramen of Monro in the third ventricle may be of particular interest because of its rarity, development of hydrocephalus, being differentiated from other brain lesions. We present a rare case of intraventricular cavernous hemangioma at foramen of Monro which was resected through microsurgery and also review the relevant literatures.

Choi, Chan-Young; Lee, Chae-Heuck



Propranolol for airway hemangiomas: case report of novel treatment.  


Infantile hemangiomas arising in the trachea are rare. These lesions pose a management dilemma as several treatment options can provide safe management. Propranolol, a nonselective beta-blocker, has recently been introduced as a novel modality for the treatment of proliferating hemangiomas. This report illustrates the successful management of tracheal hemangiomas using oral propranolol in a young patient with otherwise treatment-resistant airway lesions. Despite various endoscopic therapeutic attempts, the patient remained stridulous with airway disease that persisted into the involution phase of the average hemangioma cycle. Within 6 weeks of beginning oral propranolol (2 mg/kg/day), her airway compromise was eliminated and she had complete resolution of endoscopically visible disease. No side effects from propranolol occurred. We propose that oral propranolol should be considered for use in airway hemangiomas. PMID:19650125

Buckmiller, Lisa; Dyamenahalli, Umesh; Richter, Gresham T



[Symptomatic vertebral hemangioma related to pregnancy. A case report].  


Hemangioma is the most common primary tumor of the spine. Pregnancy is a risk factor increasing the possibility of disclosure or exacerbation of symptoms of spinal hemangioma. This paper presents a case of 32-year-old woman with hemangioma of Th6 vertebrae, which was revealed by paresis of the lower limbs and sphincters dysfunction at 34 weeks gestation. Pregnancy has ended with a cesarean section. Then posterolateral thoracotomy and removal of hemangioma were performed. Spinal cord was decompressed and stabilization of the spine with metal implants was carried out. Histological examination discovered cavernous hemangioma weaving. The patient is followed up in the outpatient clinic. Despite the improvement of neurological status--enhancement of the sensory function and development of bladder and rectal sphincter automatism--she did not regain the ability to walk alone. PMID:22384642

Jankowski, Roman; Nowak, Stanis?aw; Kasprzyk, Mariusz; Szpurek, Dariusz; Zukiel, Ryszard; Sokó?, Bartosz; Szmeja, Jacek; Szubert, Sebastian



Recurrent Orbital Cavernous Hemangioma due to Overlooked Multiple Tumors  

PubMed Central

Purpose To report late recurrence of orbital cavernous hemangioma in a patient ten years after complete resection of the primary tumor. Case Report A 32-year-old woman with a history of progressive visual loss and proptosis underwent lateral orbitotomy for resection of a large cavernous hemangioma. Ten years later, proptosis recurred and the patient developed progressive ocular deviation. Imaging studies were in favor of a recurrent cavernous hemangioma and the tumor was excised via the previous incision site. Reassessment of previous orbital images suggested the presence of two separate tumors, only one of which had been excised at the time of initial surgery. Conclusion Recurrent orbital cavernous hemangioma may follow incomplete excision of multiple orbital lesions with gradual growth of unidentified residual tumors. Accordingly, when an encapsulated cavernous hemangioma is removed, exploration is recommended to rule out multiple lesions.

Bagheri, Abbas; Khandan, Sakineh; Salour, Hossein; Aletaha, Maryam; Abrishami, Alireza



Technetium-99m-labeled red blood cells in the evaluation of hemangiomas of the liver in infants and children  

SciTech Connect

The vascular origin lesions of the liver (capillary hemangioma/infantile hemangioendothelioma) that present in infancy or early childhood often have a typical clinical picture of hepatomegaly and congestive heart failure. These lesions rarely present as asymptomatic hepatomegaly, simulating a primary hepatic malignancy. These lesions may also simulate a primary or secondary hepatic malignancy on cross-sectional imaging or angiography. Scintigraphic evaluations with technetium-99m-labeled red blood cells offers an accurate method of identification of these lesions, and allows differentiation from other common primary or secondary hepatic masses in infancy or childhood. This scintigraphic method may also be used to follow these patients after medical, radiation, or embolization therapy. Experience with seven patients with these tumors is reported and compared with eight children with other primary or secondary liver tumors also evaluated by this method.

Miller, J.H.



Giant Museum  

NSDL National Science Digital Library

In this activity children predict the size of a giant scale model of a rectangular object such as comb. They then make a model and check their predictions. Students should be familiar with measuring before beginning this activity.



Giant Squid  

NSDL National Science Digital Library

How do you get two dead Giant Squid the size of a school bus from a fishing boat in Spain to a museum in Washington, DC, USA? Call in the Navy! Find out how Operation Calamari unfolded and how the museum managed to put their new Giant Squid on display. Also included is a Learn More section that provides background information on the scientists recorded in the podcast, lessons, images, and cool facts.



[A case of cavernous hemangioma of the retina].  


A case of hemangioma of the retina is reported. Its typical ophtalmoscopic and fluorescein angiographic aspects are studied. The benign evolution is stressed in spite of a possible macular risk checked by argon laser therapy. PMID:155110

Salvanet, A; Cherifi, M; Goudou, C; Courson, J P; Mawas, E



Lack of expression of podoplanin by microvenular hemangioma  

Microsoft Academic Search

Microvenular hemangioma (MH) is not a very common type of hemangioma, and it can occasionally be difficult to distinguish it from other benign vascular tumors and malignant tumors such as Kaposi's sarcoma. The latter has been shown to be negative for the marker D2-40. Nevertheless, the status of MH for D2-40 has not been established yet. We therefore studied the

Angel Fernandez-Flores



[Diagnostic imaging of hemangiomas in the brain].  


In this study, we reviewed the findings of diagnostic imaging of cerebral vascular anomalies classified as cerebral cavernous malformation (CCM)/hemangioma, developmental venous anomalies (DVAs)/venous malformation (VM), and capillary telangiectasia. In addition, we described the imaging findings of cavernous sinus hemangioma and orbital hemangioma/vascular anomaly. CCM has 2 forms: a sporadic form characterized by isolated lesions and a familial form characterized by multiple lesions with an autosomal dominant mode of inheritance. Furthermore, CCMs are divided into 4 categories on the basis of magnetic resonance (MR) signal intensities on T1-, T2-, and gradient-echo (GRE) T2*-weighted images. In general, the lesion is hyper- or hypointense or has a core of reticulated signal intensity surrounded by a hypointense rim on conventional T2-weighted images. DVAs are characterized by the presence of a cluster of venous radicles that converge into a collecting vein, resulting in the typical caput medusae appearance of the lesion. Noncontrast T1- and T2-weighted images show flow voids and phase-shift artifact produced by the collecting vein of a DVA and by the large venous radicles of the caput medusae. Three-dimensional contrast-enhanced GRE T1-weighted imaging is useful for the assessment of morphological features of DVAs. In some cases, changes in parenchymal signal intensity within the drainage territory of the DVA are identified on T2-weighted image and fluid-attenuated inversion recovery (FLAIR) image. Capillary telangiectasias are small lesions and tend to appear as faintly hyperintense regions on T2-weighted image and faintly enhanced regions with a brush-like appearance. Results of susceptibility-weighted imaging (SWI) characteristically show this lesion as a hypointense mass. SWI is a novel imaging technique that exploits phase shifts to maximize sensitivity to differences between magnetic susceptibility between adjacent tissues. This technique is widely used with 3-T MR machines. SWI has improved the diagnosis of microbleeds, brain tumor, cerebrovascular disease, degenerative disease, etc. SWI is superior to GRE T2*-weighted imaging for determining hemosiderin, methohemoglobin, and deoxyhemoglobin contents. The sensitivity of SWI for determining the number of CCM lesions is significantly higher than that of GRE T2*-weighted imaging. PMID:21228443

Toyoda, Keiko; Oba, Hiroshi



A rare case of abnormal uterine bleeding caused by cavernous hemangioma: a case report  

Microsoft Academic Search

INTRODUCTION: Cavernous hemangiomas of the uterus are extremely rare, benign lesions. A survey of the current literature identified fewer than 50 cases of hemangioma of the uterus. CASE PRESENTATION: We report a case of cavernous hemangioma of the uterus in a 27-year-old Malay, para 1 woman who presented at our hospital with torrential vaginal bleeding having been transferred by land

Mridula A Benjamin; Hjh Roselina Yaakub; PU Telesinghe; Gazala Kafeel



Use of potassium titanyl phosphate (KTP) laser in management of subglottic hemangiomas  

Microsoft Academic Search

Objective: to study the role of KTP laser in management of subglottic hemangioma. Design: retrospective analysis of patients with subglottic hemangioma treated by the senior authors. Setting: tertiary care teaching hospital. Patients: twelve patients with subglottic hemangiomas. Intervention: patients were treated with KTP laser (eight cases), CO2 laser (two cases) or observation (two cases). Main outcome measure: resolution of symptoms,

Ashutosh Kacker; Max April; Robert F. Ward



Treatment and Pain Relief of Ulcerative Hemangiomas with a Polyurethane Film  

Microsoft Academic Search

Background: Hemangiomas are the most common tumors occurring in young children. The most common complication in the growing phase of hemangioma is ulceration. Aim and Method: We report healing, pain relief and evolutive effects of a polyurethane film in 8 cases with ulcerative hemangiomas. Results: In all 8 infants, prompt pain relief and healing within 1–2 months were observed. An

Arnold P. Oranje; Flora B. de Waard-van der Spek; Arjan C. A. Devillers; Peter de Laat; Gerard C. Madern



Unstable Giants  

Microsoft Academic Search

We find giant graviton solutions in Frolov's three parameter generalization\\u000aof the Lunin-Maldacena background. The background we study has\\u000a$\\\\tilde{\\\\gamma}_1=0$ and $\\\\tilde{\\\\gamma}_2=\\\\tilde{\\\\gamma}_3=\\\\tilde{\\\\gamma}$.\\u000aThis class of backgrounds provide a non-superymmetric example of the gauge\\u000atheory\\/gravity correspondence that can be tested quantitatively, as recently\\u000ashown by Frolov, Roiban and Tseytlin. The giant graviton solutions we find have\\u000aa greater energy than the

Robert de Mello Koch; Norman Ives; Jelena Smolic; Milena Smolic



Giant Pandas  

NSDL National Science Digital Library

The Smithsonian Institution National Zoological Park presents this extensive curriculum guide focused on the giant panda, one of the zoo's most famous denizens. Three sets of multidisciplinary lesson plans -- for grades K-4, 5-8, and 9-12 -- "contain all necessary background information and explore giant panda biology, habitat, zoo science, and conservation efforts." For example, the curriculum guide for grades 9-12 includes lesson plans addressing animal behavior and interdependence, the biomes of China, land-use planning, creative writing, and more. Students may also take advantage of the zoo's many other panda-related resources available online.


Retroperitoneal cavernous hemangioma resected by a pylorus preserving pancreaticoduodenectomy.  


A retroperitoneal hemangioma is a rare disease. We report on the diagnosis and treatment of a retroperitoneal hemangioma which had uncommonly invaded into both the pancreas and duodenum, thus requiring a pylorus preserving pancreaticoduodenectomy (PpPD). A 36-year-old man presented to our hospital with abdominal pain. An enhanced computed tomography scan without contrast enhancement revealed a 12 cm × 9 cm mass between the pancreas head and right kidney. Given the high rate of malignancy associated with retroperitoneal tumors, surgical resection was performed. Intraoperatively, the tumor was inseparable from both the duodenum and pancreas and PpPD was performed due to the invasive behavior. Although malignancy was suspected, pathological diagnosis identified the tumor as a retroperitoneal cavernous hemangioma for which surgical resection was the proper diagnostic and therapeutic procedure. Reteoperitoneal cavernous hemangioma is unique in that it is typically separated from the surrounding organs. However, clinicians need to be aware of the possibility of a case, such as this, which has invaded into the surrounding organs despite its benign etiology. From this case, we recommend that combined resection of inseparable organs should be performed if the mass has invaded into other tissues due to the hazardous nature of local recurrence. In summary, this report is the first to describe a case of retroperitoneal hemangioma that had uniquely invaded into surrounding organs and was treated with PpPD. PMID:23901241

Hanaoka, Marie; Hashimoto, Masaji; Sasaki, Kazunari; Matsuda, Masamichi; Fujii, Takeshi; Ohashi, Kenichi; Watanabe, Goro



Scl gene construction, expression and effect on hemangioma.  


Hemangioma is a tumor that causes vascular endothelial cell hyperplasia, which commonly occur in newborns. Angiogenesis inhibitor targets the processes of angiogenesis, including the proliferation of vascular endothelial cells. A DNA sequence named Scl was designed, recombined into Pichia Pastoris, expressed by fermenting the engineered strain in a bioreactor, and purified the recombinant Scl by SP-sepharose fast flow. Scl can inhibit CAM angiogenesis. Only 1 ?g of Scl significantly suppressed the growth of CAM blood vessel, similar to that of 25 ?g of angiostatin. Scl showed a strong cytotoxicity on hemangioma cell (ATCC CRL No. 2587). After the drug acted for 24 h, the OD 570 measured value of the PBS control group averaged 1.873, whereas that of the Sc1 drug group was 0.692 (P < 0.01). Using the DeadEndTM Fluorometric TUNEL System, the detection results showed that 92 % of hemangioma cell apoptosis was observed in the Scl protein group, but only 1.3 % in the PBS control group (P < 0.01). After 2 weeks of treatment with the hemangioma model (cock's wattle) of the PBS group, 151 blood vessels with 100 views (40×) were obtained, whereas 250 in the PBS group (P < 0.01). During the two-week medication, the hemangioma model of the PBS group increased by 1.18 cm, whereas only 0.58 cm in the Scl drug group (P < 0.01). PMID:23271126

Yin, H X; Zhang, Z H; Shen, J C; Zhang, A L; Zhang, T Y; Luo, J X; Fu, C Y; Yi, X P; Liu, Z W; Yang, S S; Zhou, B; Fu, X



Treatment of hemangiomas of the head and neck.  


Hemangiomas are a group of pediatric tumors that present at or soon after birth. Rapid proliferation is seen in the neonatal period, and may continue for the first year of life. Involution follows, and may last as long as 12 years. Since hemangiomas invariably involute, the vast majority have been left untreated. At least 10% to 20% of cases, however, will need active intervention, traditionally in the form of oral Prednisone. The frequent occurrence of life-threatening complications, permanent deformities, and irreversible psychosocial damage in spite of adequate steroid therapy necessitated a fresh look at the management of these lesions. Using recently developed laser technology alone or in combination with surgical excision, the authors have developed guidelines for safe intervention in all stages of the hemangioma cycle. Safe, active intervention in accordance with these guidelines offers an alternative to the more conservative approach previously advocated. PMID:1405964

Waner, M; Suen, J Y; Dinehart, S



Oral Propranolol for Treatment of Pediatric Capillary Hemangiomas  

PubMed Central

Purpose To report the long-term results of treatment of pediatric capillary hemangiomas with oral propranolol. Methods Three infants, 3 to 4 months of age, with periocular capillary hemangiomas were treated with oral propranolol solution (Inderal, 20mg/5ml) 2-3 mg/kg per day divided in 2 doses. Propranolol was continued up to the end of the first year of life and tapered over 2-3 weeks. All infants were followed for 20 months. Lesion size and evolution were assessed during the follow-up period. Results Significant improvement was noted in all patients in the first 2 months of therapy with slow and continuous effect throughout the follow-up period. No serious complications were observed. Conclusion Oral propranolol can be used as a first line agent in children with capillary hemangiomas.

Aletaha, Maryam; Salour, Hossein; Bagheri, Abbas; Raffati, Nasrin; Amouhashemi, Nassim



Failure to thrive in infants with complicated facial hemangiomas.  


We have observed that some children with facial hemangiomas of infancy have feeding difficulties coincident with periods of failure to thrive. We evaluated the early oral sensory and feeding experiences of four children with facial hemangiomas through medical record review and parental surveys to investigate their contribution to the patients' failure to thrive. All children with feeding irregularities experienced some degree of oral sensory impairment and required early oral sensory intervention, but there were varying reports of difficulty or delay in the development of oral feeding. The nature of these difficulties is discussed. Infants with complicated facial hemangiomas with perioral and airway involvement may be at higher risk for feeding and oral sensory problems. We recommend close monitoring for failure to thrive and early evaluation by speech or occupational therapists. PMID:21950618

Thomas, Meghan W; Burkhart, Craig N; Vaghani, Sapna P; Morrell, Dean S; Wagner, Annette M



Hepatic vascular anomalies in infancy: A twenty-seven-year experience  

Microsoft Academic Search

OBJECTIVE: Infantile hemangioma and arteriovenous malformation (AVM) of the liver have a similar presentation but a different natural history, and therefore require different treatment. This study was undertaken to clarify differential diagnosis and management of these two biologically distinct vascular disorders. STUDY DESIGN: We retrospectively analyzed the records of 43 children with hepatic vascular anomalies treated during the past 27

Laurence M. Boon; Patricia E. Burrows; Harriet J. Paltiel; Dennis P. Lund; R. Alan B. Ezekowitz; Judah Folkman; John B. Mulliken



Gamma Knife Radiosurgery for Choroidal Hemangioma  

SciTech Connect

Purpose: Patients with choroidal hemangioma (CH), a benign ocular hamartoma, frequently presents with visual disturbance as a result of exudative retinal detachment (RD), which originates in subretinal fluid accumulation. We report our experience using the Leksell Gamma Knife in the management of symptomatic CH. Methods and Materials: Seven patients with symptomatic CH (circumscribed form in 3 patients and diffuse form in 4) were treated with the Leksell Gamma Knife at our institution during a 7-year period. All patients presented with exudative RD involving the macula that resulted in severe visual deterioration. The prescription dose to the target margin was 10 Gy in all cases. The mean tumor volume receiving the prescription dose was 536 mm{sup 3} (range, 151-1,057). The clinical data were analyzed in a retrospective fashion after a mean follow-up of 34.4 months (range, 9-76). Results: The resolution of exudative RD was achieved within 6 months, and the visual acuity of the affected eye had improved at the latest follow-up examination (p = .018) in all patients. No recurrence of exudative RD occurred. Thinning of the CHs was observed in most patients; however, symptomatic radiation toxicity had not developed in any of the patients. Conclusion: Symptomatic CHs can be safely and effectively managed with Gamma Knife radiosurgery using a marginal dose of 10 Gy.

Kim, Yun Taek; Kang, Se Woong [Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of); Lee, Jung-Il, E-mail: [Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of)



Role of connexins in infantile hemangiomas  

PubMed Central

The circulatory system is one of the first systems that develops during embryogenesis. Angiogenesis describes the formation of blood vessels as a part of the circulatory system and is essential for organ growth in embryogenesis as well as repair in adulthood. A dysregulation of vessel growth contributes to the pathogenesis of many disorders. Thus, an imbalance between pro- and antiangiogenic factors could be observed in infantile hemangioma (IH). IH is the most common benign tumor during infancy, which appears during the first month of life. These vascular tumors are characterized by rapid proliferation and subsequently slower involution. Most IHs regress spontaneously, but in some cases they cause disfigurement and systemic complications, which requires immediate treatment. Recently, a therapeutic effect of propranolol on IH has been demonstrated. Hence, this non-selective ?-blocker became the first-line therapy for IH. Over the last years, our understanding of the underlying mechanisms of IH has been improved and possible mechanisms of action of propranolol in IH have postulated. Previous studies revealed that gap junction proteins, the connexins (Cx), might also play a role in the pathogenesis of IH. Therefore, affecting gap junctional intercellular communication is suggested as a novel therapeutic target of propranolol in IH. In this review we summarize the current knowledge of the molecular processes, leading to IH and provide new insights of how Cxs might be involved in the development of these vascular tumors.

Blanke, Katja; Dahnert, Ingo; Salameh, Aida



Isolated cavernous hemangioma: a rare benign lesion of the stomach.  


Gastric cavernous hemangioma is a relatively rare benign gastric disease. Here we report the case of a 25-year-old male patient who had been admitted complaining of epigastric pain and hematemesis. Preoperative imaging indicated that the mass lesion palpated in the epigastric region was a probable mesenchymal tumor of gastric origin. Due to the hypervascular nature and submucosal localization of the mass, we did not obtain definitive preoperative diagnosis by endoscopic biopsy. The histologic diagnosis of cavernous hemangioma was confirmed by post-resection histopathologial evaluation of the mass. PMID:23024741

Basbug, Murat; Yavuz, Ridvan; Dablan, Mahmut; Baysal, Birol; Gencoglu, Metehan; Yagmur, Yusuf



Isolated Cavernous Hemangioma: A Rare Benign Lesion of the Stomach  

PubMed Central

Gastric cavernous hemangioma is a relatively rare benign gastric disease. Here we report the case of a 25-year-old male patient who had been admitted complaining of epigastric pain and hematemesis. Preoperative imaging indicated that the mass lesion palpated in the epigastric region was a probable mesenchymal tumor of gastric origin. Due to the hypervascular nature and submucosal localization of the mass, we did not obtain definitive preoperative diagnosis by endoscopic biopsy. The histologic diagnosis of cavernous hemangioma was confirmed by post-resection histopathologial evaluation of the mass.

Basbug, Murat; Yavuz, Ridvan; Dablan, Mahmut; Baysal, Birol; Gencoglu, Metehan; Yagmur, Yusuf



Efficacy of bleomycin treatment for symptomatic hemangiomas in children.  


Five children aged 5-19 years had pain in massive, inoperable hemangiomas. They were treated with intralesional injections of 2 mg bleomycin as a 0.4 mg/ml solution in the painful area. The injections were repeated after 4 -6 weeks for a total of 6 -10 times. All children were relieved of pain, and the swelling was reduced in all cases. There were no complications or side effects. Bleomycin therapy of painful, massive hemangiomas can be recommended in older children. PMID:9238123

Kullendorff, C M



Intralesional bleomycin for the treatment of periocular capillary hemangiomas  

PubMed Central

Periocular infantile capillary hemangiomas do not always respond well to conventional treatment modalities such as systemic or intralesional corticosteroids, radiotherapy or debulking surgery. The authors describe the use of intralesional bleomycin injections (IBIs) to treat potentially amblyogenic lesions in two cases where other modalities have failed. In both cases monthly IBIs successfully cleared the visual axis of the affected eye before the age of 1 year thus preventing permanent sensory deprivation amblyopia. A total of five and nine injections, respectively, were used and no significant side effects were noted. IBI appears to be a useful alternative in the treatment of periocular capillary hemangiomas refractory to more conventional modalities.

Smit, Derrick P; Meyer, David



Benign Adrenal Hemangiomas May Mimic Metastases on PET.  


CT or MRI are utilized in the initial evaluation of adrenal incidentalomas; however, overlap exists between benign and malignant lesions on these examinations. The American College of Radiology recommends PET scans to complement CT and MRI for patients with adrenal masses and a moderate-to-high likelihood of neoplastic disease. We present images of a PET-avid adrenal lesion in a patient with pulmonary and pancreatic neoplasms that mimicked metastasis, but was found to be a benign adrenal hemangioma on surgical resection. The use of PET for adrenal tumors, specifically adrenal hemangiomas, will be reviewed. PMID:24089061

Calata, Jed F; Sukerkar, Arun N; August, Carey Z; Maker, Ajay V



Uterine glomeruloid hemangioma in a patient without POEMS syndrome.  


Cutaneous glomeruloid hemangioma is a hallmark of POEMS syndrome. These patients have elevated serum levels of vascular endothelial growth factor. The authors report an extracutaneous uterine glomeruloid hemangioma in an 82-year-old woman with a history of breast and endometrial carcinomas. Within the lumen of myometrial vessels, a lobular, glomeruloid proliferation of capillary-like CD31 and vascular endothelial growth factor receptor-1-positive endothelial cells was found. The capillary loops were lined by endothelial cells, most of them containing PAS-positive and immunoglobulin-positive eosinophilic hyaline globules (thanatosomes). This vascular proliferation was consistent with a glomeruloid hemangioma. Although an extracutaneous glomeruloid vascular proliferation has been found in the retroperitoneal adipose tissue in a patient with POEMS syndrome, this study reports what seems to be the first case of visceral glomeruloid hemangioma in a patient without POEMS syndrome. The authors hypothesize that the glomeruloid endothelial cell proliferation with vascular endothelial growth factor receptor-1 expression may be a paraneoplastic phenomenon. PMID:22134630

Giner, Francisco; Compañ, Amparo; Monteagudo, Carlos



Follow-Up of an Unresectable Hemangioma in the Heart.  


We present the case of a patient with a hemangioma, a benign heart tumor, that is revealed incidentally during cardiac catheterization. The patient had coexisting coronary artery disease. This rare tumor remained unchanged in size, and the patient has been asymptomatic for a period of 20 years. PMID:11175035

Chrissos, Dimitrios N.; Agelopoulos, Nicolaos G.; Garyfallos, Dimitirios J.; Stergiopoulou, Polyxeni D.



Computed tomography in spinal hemangioma with cord compression  

Microsoft Academic Search

Two teenagers with spinal cord compression due to a thoracic vertebral hemangioma are presented. Myelography showed a complete block in both patients. Selective intercostal arteriography was normal or non-conclusive. Only computed tomography (CT) gave precise information about the extent and nature of the compressive lesion. In the first case it showed angiomatous involvement of the body and all parts of

P. Schnyder; H. Fankhauser; B. Mansouri



Vascular tumors of infancy and childhood: beyond capillary hemangioma  

Microsoft Academic Search

Vascular tumors of infancy and childhood represent a number of clinicopathologically distinct entities for which precise histopathological diagnosis is often essential in determining effective therapeutic approach. Unfortunately, pathologists and clinicians alike have traditionally tended to lump these tumors, in addition to small vessel vascular malformations, under overly generic terms like capillary hemangioma that do little, if anything, to guide proper

Paula E. North; Milton Waner; Lisa Buckmiller; Charles A. James; Martin C. Mihm



A rare tumor of the lung: pulmonary sclerosing hemangioma (pneumocytoma).  


A 67-year-old woman was referred to our department for further evaluation of her abnormal, chest radiogram. Thorax computed tomography revealed a well-circumscribed, round mass in the middle lobe of the right lung. A thoracotomy was performed and pulmonary sclerosing hemangioma was diagnosed. We herein present a rare tumor of the lung. PMID:23290153

Baysak, Aysegul; Oz, Adnan Tolga; Mo?ulkoç, Nesrin; Bishop, Paul William; Ceylan, Kenan Can



Difficult preoperative diagnosis of a patient with sclerosing splenic hemangioma  

SciTech Connect

We present a young asymptomatic woman with splenomegaly and a large isolated splenic mass demonstrated by ultrasonography, /sup 99m/Tc sulfur colloid, and gallium scintigraphy studies. Computerized tomography (CT) and three-phase 99mTc-labeled red blood cell imaging suggested a malignant lesion. Repeated sonographically guided fine needle aspiration (FNA) obtained only blood, suggesting the possible vascular nature of the tumor. Splenectomy established the diagnosis of splenic hemangioma (SH) with marked sclerotic changes. We conclude from this case that (1) the sclerotic and cystic changes in the SH and the abdominal lymphadenopathy could explain why the three-phase red blood cell and CT scanning, respectively, suggested that the lesion was malignant rather than benign; (2) guided FNA of a splenic mass suspected to be hemangioma may be an additional safe and useful diagnostic procedure. Multiple aspirations yielding blood alone suggest hemangioma and may prevent an unnecessary operation. To the best of our knowledge, this is the first reported case in the literature of FNA of splenic hemangioma.

Edoute, Y.; Ben-Haim, S.A.; Ben-Arie, Y.; Fishman, A.; Barzilai, D.



Right atrial hemangioma in the newborn: Utility of fetal imaging  

PubMed Central

We present a rare primary right atrial tumor diagnosed in-utero with fetal echocardiography, and further characterized as a congenital hemangioma with magnetic resonance imaging. Surgical resection was done six days after birth. This case illustrates the complementary roles of evolving advanced imaging techniques for fetuses and infants with congenital heart disease that allows for surgery early in the neonatal period.

Baird, Christopher; Blalock, Shannon; Bengur, Resai; Ikemba, Catherine



Durable response of intracranial cellular hemangioma to bevacizumab and temozolomide.  


Cellular hemangioma is a subtype of hemangioma that is associated with cellular immaturity and the potential for recurrence. Intracranial location of these lesions is extremely rare, and definitive treatment often requires radical neurosurgical resection. The authors report a case of a 12-year-old boy with a subtemporal cellular hemangioma. He underwent gross-total resection of the tumor, but within 1.5 months the tumor recurred, necessitating a second resection. Because of its proximity to vascular structures, only subtotal resection was possible. Repeat MRI 1 month after the second surgery showed significant tumor recurrence. Given the tumor's demonstrated capacity for recurrence and its proximity to the vein of Labbé and sigmoid sinus, further resection was not indicated. In an effort to limit radiation therapy for this young patient, treatment with bevacizumab and temozolomide was chosen and achieved a complete response that has proven durable for 36 months after cessation of therapy. This is the first report of the successful use of chemotherapy to treat an intracranial hemangioma, a rare condition with limited therapeutic options. PMID:23540527

Yeo, Kee Kiat; Puscasiu, Elena; Keating, Robert F; Rood, Brian R



Suppressed NFAT-dependent VEGFR1 expression and constitutive VEGFR2 signaling in infantile hemangioma  

Microsoft Academic Search

Infantile hemangiomas are localized and rapidly growing regions of disorganized angiogenesis. We show that expression of vascular endothelial growth factor receptor-1 (VEGFR1) in hemangioma endothelial cells (hemECs) and hemangioma tissue is markedly reduced compared to controls. Low VEGFR1 expression in hemECs results in VEGF-dependent activation of VEGFR2 and downstream signaling pathways. In hemECs, transcription of the gene encoding VEGFR1 (FLT1)

Masatoshi Jinnin; Damian Medici; Lucy Park; Nisha Limaye; Yanqiu Liu; Elisa Boscolo; Joyce Bischoff; Miikka Vikkula; Eileen Boye; Bjorn R Olsen



Rapamycin suppresses self-renewal and vasculogenic potential of stem cells isolated from infantile hemangioma.  


Infantile hemangioma (IH) is a common childhood vascular tumor. Although benign, some hemangiomas cause deformation and destruction of features or endanger life. The current treatments, corticosteroid or propranolol, are administered for several months and can have adverse effects on the infant. We designed a high-throughput screen to identify the Food and Drug Administration-approved drugs that could be used to treat this tumor. Rapamycin, an mTOR (mammalian target of Rapamycin) inhibitor, was identified, based on its ability to inhibit proliferation of a hemangioma-derived stem cell population, human vasculogenic cells, which we had previously discovered. In vitro and in vivo studies show that Rapamycin reduces the self-renewal capacity of the hemangioma stem cells, diminishes differentiation potential, and inhibits the vasculogenic activity of these cells in vivo. Longitudinal in vivo imaging of blood flow through vessels formed with hemangioma stem cells shows that Rapamycin also leads to regression of hemangioma blood vessels, consistent with its known anti-angiogenic activity. Finally, we demonstrate that Rapamycin-induced loss of stemness can work in concert with corticosteroid, the current standard therapy for problematic hemangioma, to block hemangioma formation in vivo. Our studies reveal that Rapamycin targets the self-renewal and vascular differentiation potential in patient-derived hemangioma stem cells, and suggests a novel therapeutic strategy to prevent formation of this disfiguring and endangering childhood tumor. PMID:21938011

Greenberger, Shoshana; Yuan, Siming; Walsh, Logan A; Boscolo, Elisa; Kang, Kyu-Tae; Matthews, Benjamin; Mulliken, John B; Bischoff, Joyce



Mechanical bowel obstruction due to colonic hemangioma: report of a case.  


Colon hemangiomas are rare benign vascular lesions which are usually seen in teenagers. The frequent presentation is repetitive painless rectal bleeding. Colonic hemangiomas are occasionally found in the rectosigmoid area. A 62-year-old male patient was admitted to the hospital with the complaints of mechanical bowel obstruction. The radiological imaging techniques revealed a transverse colon tumor. Consequently, the patient was operated, and transverse colectomy and end-to-end anastomosis were performed. No postoperative complications occurred. The pathologic examination revealed cavernous hemangioma of the transverse colon. This report describes a very rare case of bowel obstruction due to colonic hemangioma. PMID:17205412

Demirba?, Tolga; Güler, Necdet; Cali?kan, Cemil; Gürcü, Bari?; Do?anav?argil, Ba?ak; Korkut, Mustafa



An exceptional cause of progressive dyspnoea in a renal transplant recipient: hemangioma of the mitral valve.  


Primary cardiac hemangioma is a very rare benign vascular tumor, with valvular hemangiomas being even less frequent as valves are generally avascular structures. We present the first case of mitral valve hemangioma in a renal transplant recipient. Patient presented with progressive dyspnea. Transesophageal echocardiogram (TEE) demonstrated a 0.8x0.9-cm pedunculated tumor mass on the posterior leaflet of the mitral valve. Coronary angiography identified a small artery which filled from the circumflex artery and fed the tumor. The tumor was surgically removed. Histopathological examination revealed a hemangioma. The postoperative course was uneventful with stable graft function. PMID:23445870

Juric, Ivana; Hadzibegovic, Irzal; Kes, Petar; Biocina, Bojan; Milicic, Davor; Basic-Jukic, Nikolina



Clitoromegaly caused by cavernous hemangioma: A rare case report and review of the literature.  


Hemangioma is a common benign neoplasm, but a location such as the clitoris is very rare. However, it is very important to differentiate clitoral hemangioma from enlargement of the clitoris secondary to androgen excess. To the best of our knowledge, only three cases of clitoromegaly caused by cavernous hemangioma have been reported in the English literature. Herein, we report our experience with a 16-year-old girl who presented with clitoromegaly and normal hormonal assay that turned out to be clitoral cavernous hemangioma after pathologic examination of the clitoral mass. PMID:23248526

Geramizadeh, Bita; Anbardar, Mohammad-Hossein; Shakeri, Saeed



Intraosseous spindle cell hemangioma of the calcaneus: a case report and review of the literature.  


Spindle cell hemangioma, a rare benign tumor characterized by cavernous blood vessels and spindled areas, typically arises in the subcutis of the distal extremities, particularly the hand. The case of intraosseous spindle cell hemangioma is extremely rare, and only 1 case arises in the frontal bone has been reported previously. We describe herein a case of intraosseous spindle cell hemangioma occurring in the left calcaneus in a 65-year-old woman. The patient was successfully treated by the operation. The present case is instructive especially in the differential diagnosis of primary bone tumor structured by spindle cells, for which the possibility of spindle cell hemangioma should be considered. PMID:22534243

Hakozaki, Michiyuki; Tajino, Takahiro; Watanabe, Kazuo; Yamada, Hitoshi; Kikuchi, Shinichi; Hojo, Hiroshi; Ishida, Tsuyoshi; Konno, Shinichi



Abnormal radionuclide liver scans in giant cell arteritis.  

PubMed Central

In the investigation of six patients with giant cell arteritis and abnormal liver function radionuclide liver scans were found to be abnormal in all. The abnormality may be due to arteritis of hepatic vessels. It is important to recognise that giant cell arteritis may cause liver scan abnormalities. If other pathology is suspected and corticosteroid treatment delayed while further investigations are carried out, patients are at risk of complications such as blindness.

Jones, J; Kyle, M V; Hazleman, B L; Wraight, P



High-Resolution Micro-CT for Morphologic and Quantitative Assessment of the Sinusoid in Human Cavernous Hemangioma of the Liver  

PubMed Central

Hepatic sinusoid plays a vital role in human cavernous hemangioma of the liver (CHL), and its morphologic investigation facilitates the understanding of microcirculation mechanism and pathological change of CHL. However, precise anatomical view of the hepatic sinusoid has been limited by the resolution and contrast available from existing imaging techniques. While liver biopsy has traditionally been the reliable method for the assessment of hepatic sinusoids, the invasiveness and sampling error are its inherent limitations. In this study, imaging of CHL samples was performed using in-line phase-contrast imaging (ILPCI) technique with synchrotron radiation. ILPCI allowed clear visualization of soft tissues and revealed structural details that were invisible to conventional radiography. Combining the computed tomography (CT) technique, ILPCI-CT was used to acquire the high-resolution micro-CT images of CHL, and three dimensional (3D) microstructures of hepatic sinusoids were provided for the morphologic depiction and quantitative assessment. Our study demonstrated that ILPCI-CT could substantially improve the radiographic contrast of CHL tissues in vitro with no contrast agent. ILPCI-CT yielded high-resolution micro-CT image of CHL sample at the micron scale, corresponding to information on actual structures revealed at histological section. The 3D visualization provided an excellent view of the hepatic sinusoid. The accurate view of individual hepatic sinusoid was achieved. The valuable morphological parameters of hepatic sinusoids, such as thrombi, diameters, surface areas and volumes, were measured. These parameters were of great importance in the evaluation of CHL, and they provided quantitative descriptors that characterized anatomical properties and pathological features of hepatic sinusoids. The results highlight the high degree of sensitivity of the ILPCI-CT technique and demonstrate the feasibility of accurate visualization of hepatic sinusoids. Moreover, there is a correlation between the CHL and the size or morphology of hepatic sinusoids, which offers a potential use in noninvasive study and analysis of CHL.

Duan, Jinghao; Hu, Chunhong; Chen, Hua



Value of T1 and T2 relaxation times from echoplanar MR imaging in the characterization of focal hepatic lesions  

Microsoft Academic Search

OBJECTIVE. The purpose of this study was to determine the value of echoplanar imaging in characterizing focal hepatic lesions on the basis of image-derived T1 and T2 relaxation times. SUBJECTS AND METHODS. Forty-six proven hepatic lesions were analyzed: 24 solid (21 metastases, three primary liver tumors) and 22 nonsolid (11 hemangiomas and 11 cysts). Mean lesion size (maximal length) was

MA Goldberg; PF Hahn; S Saini; M. S. Cohen; P Reimer; TJ Brady; PR Mueller



What Is Giant Cell Arteritis?  


... Sun Eye Health News Consumer Alerts What Is Giant Cell Arteritis? Tweet Giant cell arteritis (GCA) is an inflammation (swelling) of ... because it affects the head (cranium). What Is Giant Cell Arteritis? Giant Cell Arteritis Symptoms Who Is ...


Intramuscular hemangioma of the masseter muscle: a case report  

PubMed Central

Intramuscular hemangiomas are uncommon neoplasm's arising most frequently in the masseter and trapezius muscle. Due to it's location it is often mistaken for a parotid swelling and rarely is an accurate pre-operative diagnosis achieved clinically. The intra masseteric location also poses special problem in terms of proximity to the facial nerve and the post operative flattening following excision of the masseter muscle. A case of intramuscular hemangioma in a 17 year old girl is presented. Inadequacy of computed tomography scan and cytology in achieving a pre-operative diagnosis and also the treatment modalities are reviewed here. An estrogen receptor and progesterone receptor study has been done to verify the hormonal basis of this tumour.

Prakash, Preeth; Dhanasekaran, C K



Percutaneous Technique for Sclerotherapy of Vertebral Hemangioma Compressing Spinal Cord  

SciTech Connect

Purpose: In this study we report a percutaneous technique to achieve sclerosis of vertebral hemangioma and decompression of the spinal cord and nerve roots. Methods: Under CT guidance the affected vertebral body is punctured by a biopsy needle and sclerosant is injected directly into the tumor. In the case of large paravertebral extension, additional injection is given in the paravertebral soft tissue component to induce shrinkage of the whole tumor mass and release of the compressed spinal cord. Results: Using this technique we treated five patients in whom vertebral hemangioma gave rise to neurologic symptoms.In three patients, sclerotherapy was the only treatment given. In the other two patients, sclerotherapy was preceded by transcatheter embolization. Neither decompressive surgery, radiation therapy nor stabilization was required with this technique. Conclusion: Our experience with CT-guided intraosseous sclerotherapy has proved highly satisfactory.

Gabal, Abdelwahab M. [Al-Azhar University Medical Center, Sayed GalalHospital, Port Saeed Str. 540, Cairo 11563 (Egypt)



Spontaneous Hemo-pneumothorax as a Result of Venous Hemangioma  

PubMed Central

Spontaneous hemopneumothorax is a rare clinical entity that can be life-threatening, with a significant increase in mortality if not recognized and treated in time. We report the case of a young man who presented to us with nontraumatic spontaneous hemopneumothorax. Histologic examination of lung tissue showed the most likely cause of the bleeding to be venous hemangioma, which to the best of our knowledge has not been reported before.

Bhaskar, Jayapadman; Sharma, Ashok K.



Outcome of dorsolumbar vertebral hemangiomas presenting with neuraxial compression  

PubMed Central

Background: Hemangiomas are benign vascular tumors associated with proliferation of blood vessels in bone or soft tissue and they are usually incidental findings in vertebrae. When symptomatic, they present with features of radiculopathy, myelopathy, or vertebral fractures. Treatment options are varied, include sole embolization, embolization combined with surgical excision, surgical excision alone, percutaneous ablation, and radiotherapy. We hereby describe a series of seven cases of symptomatic vertebral hemangiomas operated from 2006 to 2009. Materials and Methods: Their clinical and radiological profile and outcome have been described. All patients were subjected to surgical excision followed by instrumentation. Outcome was assessed at a followup of 2 years following surgery with Frankel grading system. Results: Seven patients (five females and two males) were included in the study. The mean age was 33.85 years with the mean duration of symptoms of 12 months. All seven cases were symptomatic vertebral hemangiomas with cord compression and underwent surgical excision. Preoperatively, patients with poor Frankel grade such as A and B improved postoperatively to C, D, or E. Conclusion: Surgical excision of these lesions is difficult due to the tremendous amount of intraoperative bleeding. During surgery, brisk bleeding is usually encountered, but can be brought under control with adequate preoperative preparation and expertize. Preoperative embolization may help to reduce the bleeding, but at times it may be difficult to do if vertebrae are replaced by a solid hard mass. In spite of the risks associated with surgery, it still is the treatment of choice as a single intervention, especially in aggressive vertebral hemangiomas.

Nair, Anup P; Kumar, Raj; Srivastav, Arun Kumar; Sahu, Rabi Narayan; Kumar, Brijesh



Hemangiomas and Vascular Malformations: Current Theory and Management  

PubMed Central

Vascular anomalies are a heterogeneous group of congenital blood vessel disorders more typically referred to as birthmarks. Subcategorized into vascular tumors and malformations, each anomaly is characterized by specific morphology, pathophysiology, clinical behavior, and management approach. Hemangiomas are the most common vascular tumor. Lymphatic, capillary, venous, and arteriovenous malformations make up the majority of vascular malformations. This paper reviews current theory and practice in the etiology, diagnosis, and treatment of these more common vascular anomalies.

Richter, Gresham T.; Friedman, Adva B.



Congenital infantile fibrosarcoma: a masquerader of ulcerated hemangioma.  


Congenital infantile fibrosarcoma, a rare malignant tumor of childhood, may present as a highly vascularized mass that is clinically difficult to distinguish from a hemangioma. When ulcerated, significant hemorrhage, anemia, and thrombocytopenia may occur in children with these lesions. This report describes three infants with ulcerated congenital infantile fibrosarcomas of the hand. As appropriate medical and surgical management hinges on timely and appropriate diagnosis, we review the clinical manifestations of these lesions. PMID:16918626

Yan, Albert C; Chamlin, Sarah L; Liang, Marilyn G; Hoffman, Benjamin; Attiyeh, Edward F; Chang, Benjamin; Honig, Paul J


Preliminary Experiences in Treating Infantile Hemangioma With Propranolol.  


The aim of this study was to evaluate the outcome of treating infantile hemangioma with the use of oral propranolol. A total of 27 patients with hemangiomas were treated with oral propranolol therapy. The subjects included 21 females and 6 males whose age ranged between 3 weeks and 7 months. Locations of lesions were as follows: 22 on the face and neck, 3 on the trunk, and 2 on the limbs. The dose of 0.5 mg/kg/d of propranolol was administered; and was gradually doubled to a maximum of 2 mg/kg/d. The treatment lasted for a period of 2.75 to 5.75 months without major complications. Two days later, a change in color was observed in 100% of patients, and 2 weeks later >75% reduction in diameter of the original lesion was found in 25.9% of patients. Treating infantile hemangioma with the use of oral propranolol is effective and reliable. PMID:21629056

Chai, Qiang; Chen, Wei-Liang; Huang, Zhi-Quan; Zhang, Da-Ming; Fan, Song; Wang, Lei



In vitro maturation of follicular oocytes of the giant panda (ailuropoda melanoleuca): A case report  

Microsoft Academic Search

The Giant Panda is an endangered species that would benefit from biotechnological assistance in reproduction. However, because there are only a few of these animals left in the world, scientists hesitate to use them for research procedures. We were fortunate to obtain ovaries from a Giant Panda that died of hepatic cirrhosis during the nonbreeding season. Oocytes were harvested within

M. J. Zhang; R. Hou; A. J. Zhang; Z. H. Zhang; G. X. He; G. H. Li; J. S. Wang; S. C. Li; Y. F. Song; L. S. Fei; H. W. Chen



Propranolol is more effective than pulsed dye laser and cryosurgery for infantile hemangiomas.  


Propranolol hydrochloride is a nonselective ?-blocker that is used for the treatment of hypertension, arrhythmia, and angina pectoris. In Japan, it was recently approved for the treatment of childhood arrhythmia. It has been observed to produce drastic involution of infantile hemangiomas. The aim of this prospective study was to examine propranolol's superiority to classical therapy with pulsed dye laser and/or cryosurgery in treating proliferating infantile hemangiomas. Fifteen patients between the ages of 1 and 4 months with proliferating infantile hemangiomas received grinded propranolol tablets 2 mg/kg per day divided in three doses. Twelve patients with proliferating infantile hemangiomas receiving pulsed dye laser and/or cryosurgery were enrolled as controls. Baseline electrocardiogram, echocardiogram, and chest x-ray were performed. Monitoring of heart rate, blood pressure, and blood glucose was performed every 2 weeks. Efficacy was assessed by performing blinded volume measurements and taking photographs at every visit. Propranolol induced significantly earlier involution and redness reduction of infantile hemangiomas, compared to pulsed dye laser and cryosurgery. Adverse effects such as hypoglycemia, hypotension, or bradycardia did not occur. Conclusion: The dramatic response of infantile hemangiomas to propranolol and few side effects suggest that early treatment of infantile hemangiomas could result in decreased disfigurement. Propranolol should be considered as a first-line treatment of infantile hemangiomas. PMID:23812512

Kagami, Shinji; Kuwano, Yoshihiro; Shibata, Sayaka; Uwajima, Yuta; Yamada, Daisuke; Miyamoto, Akie; Miyagawa, Takuya; Araki, Mayuko; Takahashi, Kohji; Isomura, Sayako; Aozasa, Naohiko; Masui, Yuri; Yamamoto, Mizuho; Inuzuka, Ryo; Katori, Tatsuo; Sato, Shinichi



Laser Ablation of a Large Tongue Hemangioma with Remifentanil Analgosedation in the ORL Endoscopy Suite  

Microsoft Academic Search

We present a unique, practical, and safe approach to the clinical management of a young male with a large tongue hemangioma who presented for serial surgical treatment of the lesion. Laser ablation was undertaken in the operating room under topical anesthesia with remifentanil analgosedation without the use of supplemental oxygen. Significant involution of the hemangioma was achieved without complication while

Joshua H. Atkins; Jeff E. Mandel; Natasha Mirza



Avian Hemangioma Retrovirus Induces Cell Proliferation via the Envelope ( env) Gene  

Microsoft Academic Search

Several years ago, a field strain retrovirus, avian hemangioma virus (AHV), was isolated from hemangioma tumors in layer hens. Sequence analysis indicated that the AHV genome contains the three prototypic retroviral genes, gag, pol, and env, and is devoid of an oncogene. In cultured endothelial cells, however, AHV induced a significant cytopathic effect through a typical apoptotic cascade. We now

Akram Alian; Dalit Sela-Donenfeld; Amos Panet; Amiram Eldor



Giant Cell Arteritis  


Giant cell arteritis is a disorder that causes inflammation of arteries of the scalp, neck, and arms. ... the arteries, which keeps blood from flowing well. Giant cell arteritis often occurs with another disorder called ...


Giant Cell Arteritis  


... prevented by prompt diagnosis and treatment. What is giant cell arteritis? GCA is a type of vasculitis ... pain right away to their doctors. What causes giant cell arteritis? As with PMR, the cause of ...


Transforming giants.  


Large corporations have long been seen as lumbering, inflexible, bureaucratic--and clueless about global developments. But recently some multinationals seem to be transforming themselves: They're engaging employees, moving quickly, and introducing innovations that show true connection with the world. Harvard Business School's Kanter ventured with a research team inside a dozen global giants--including IBM, Procter & Gamble, Omron, CEMEX, Cisco, and Banco Real--to discover what has been driving the change. After conducting more than 350 interviews on five continents, she and her colleagues came away with a strong sense that we are witnessing the dawn of a new model of corporate power: The coordination of actions and decisions on the front lines now appears to stem from widely shared values and a sturdy platform of common processes and technology, not from top-down decrees. In particular, the values that engage the passions of far-flung workforces stress openness, inclusion, and making the world a better place. Through this shift in what might be called their guidance systems, the companies have become as creative and nimble as much smaller ones, even while taking on social and environmental challenges of a scale that only large enterprises could attempt. IBM, for instance, has created a nonprofit partnership, World Community Grid, through which any organization or individual can donate unused computing power to research projects and see what is being done with the donation in real time. IBM has gained an inspiring showcase for its new technology, helped business partners connect with the company in a positive way, and offered individuals all over the globe the chance to contribute to something big. PMID:18271317

Kanter, Rosabeth Moss



Sacroplasty for symptomatic sacral hemangioma: a novel treatment approach. A case report.  


Painful vertebral body hemangiomas have been successfully treated with vertebroplasty and kyphoplasty. Sacral hemangiomas are uncommon and as such painful sacral hemangiomas are rare entities. We report what we believe is only the second successful treatment of a painful sacral hemangioma with CT-guided sacroplasty. A 56-year-old woman with a history of right-sided total hip arthroplasty and lipoma excision presented to her orthopedic surgeon with persistent right-sided low back pain which radiated into her buttock and right groin and hindered her ability to walk and perform her activities of daily living. MRIs of the thoracic spine, lumbar spine and pelvis showed numerous lesions with imaging characteristics consistent with multiple hemangiomas including a 2.2×2.1 cm lesion involving the right sacrum adjacent to the right S1 neural foramen. Conservative measures including rest, physical therapy, oral analgesics and right-sided sacroiliac joint steroid injection did not provide significant relief. Given her lack of improvement and the fact that her pain localized to the right sacrum, the patient underwent CT-guided sacroplasty for treatment of a painful right sacral hemangioma. Under CT fluoroscopic guidance, a 10 gauge introducer needle was advanced through the soft tissues of the back to the margin of the lesion. Biopsy was then performed and after appropriate preparation, cement was then introduced through the needle using a separate cement filler cannula. Appropriate filling of the right sacral hemangioma was visualized using intermittent CT fluoroscopy. After injection of approximately 2.5 cc of cement, it was felt that there was near complete filling of the right sacral hemangioma. With satisfactory achievement of cement filling, the procedure was terminated. Pathology from biopsy taken at the time of the procedure was consistent with hemangioma. Image-guided sacroplasty with well-defined endpoints is an effective, minimally invasive and safe procedure. Patients with painful sacral hemangiomas can be treated with this technique with no significant complications. PMID:23693051

Agarwal, V; Sreedher, G; Weiss, K R; Hughes, M A



Targeted hemosiderotic hemangioma: a case report of multiple asymptomatic lesions.  


Targetoid hemosiderotic hemangioma (THH) is a benign vascular tumor characterized by a central violaceous papule with a clear periphery bordered by an ecchymotic ring. Originally coined by its characteristic halo appearance with hemosiderin deposits, not all THHs have this classic halo or hemosiderin composition. We report a unique case of THH in which the patient presented with multiple lesions with no prior trauma. Multiple THH lesions have been linked to minor trauma; however, the presence of 4 concurrent lesions with the absence of trauma makes this THH presentation atypical and unique. PMID:24087783

Cleaver, Jonathan L; Cleaver, Nathan J; Cleaver, Lloyd J



Management of infantile hemangiomas : current and potential pharmacotherapeutic approaches.  


Infantile hemangiomas (IH), benign vascular neoplasms, are the most common tumors of infancy and childhood. Most IH are medically insignificant; however, a proportion will require treatment because of interference with vital structures, threat of significant disfigurement, ulceration, or bleeding. This article reviews current and potential pharmacotherapeutic approaches to the treatment of IH. While corticosteroids have long been considered the mainstay of medical therapy for IH, several new treatments have recently emerged, the most promising of which is oral propranolol. Topical timolol and imiquimod are additional new therapies that may also prove to be effective, particularly for the treatment of superficial IH. PMID:23456550

Craiglow, Brittany G; Antaya, Richard J



A study of histogenesis of pulmonary sclerosing hemangioma  

Microsoft Academic Search

Objective  To investigate the histogenesis and differential diagnosis of pulmonary sclerosing hemangioma (PSH).\\u000a \\u000a \\u000a \\u000a Methods  Thyroid transcription factor-1 (TTF-1), surfactant proteins A, B (SP-A, SP-B), epithelial membrane antigen (EMA), vimentin,\\u000a pancytokeratin, cytokeratin7 (CK7), CK5\\/6, calretinin, S-100, neurospecific enolase (NSE), synaptophysin (Syn), chromogranin\\u000a A (CgA), CD34, factor-VIII-related antigen (F-VIII) and smooth muscle actin (SMA) in 55 patients with PSH were examined with\\u000a immunohistochemistry, while

Xiao Zhou; Xianghua Yi; Meifang Zhu



Congenital infantile fibrosarcoma: a clinical mimicker of hemangioma.  


Congenital infantile fibrosarcoma (CIFS) is a rare pediatric soft tissue tumor; clinically, it presents as a highly vascular mass and may simulate a hemangioma. It usually occurs in the first year of life and has a relatively better prognosis compared to other aggressive spindle cell sarcomas of childhood. We report a patient with CIFS who presented with a nonspecific ulcerated mass lesion over the right shoulder region that was clinically diagnosed as a benign vascular lesion. Histology revealed a highly cellular tumor with closely packed fascicles of spindle cells. Immunohistochemically, the tumor cells expressed vimentin. PMID:22474726

Jain, Deepali; Kohli, Kavita



Unusual Features in an Adult Pancreatic Hemangioma: CT and MRI Demonstration  

PubMed Central

Hemangiomas in the pancreas are very rare and only a few cases in adulthood have been reported in the literature. We describe a case of pancreatic hemangiomas in an adult with unique imaging findings. A 23-year-old woman visited the hospital for an incidentally detected pancreatic mass. CT and MRI revealed a multilocular cyst with fluid-fluid levels and no obvious enhancement. The patient underwent surgery and the mass was confirmed as a pancreatic hemangioma. The radiological features and differential diagnosis of this rare lesion are discussed.

Wu, Mei



Successful detection and surgical treatment of cardiac hemangioma with right ventricular invasion.  


Cardiac hemangiomas are extremely rare benign tumors. These tumors are usually asymptomatic but they can present symptoms such as palpitations, shortness of breath, and arrythmia. We report the case of a 73-year-old man who presented with an abnormal shadow on chest computed tomography during follow-up for lung metastatic tumor after resection of his rectal cancer. A cardiac tumor was detected, and surgical resection and right ventricular plasty were successfully performed with the patient under cardiopulmonary bypass. Histopathologic examination revealed a benign cardiac hemangioma, which was categorized as a hemangioma of the mixed cavernous and capillary type. PMID:24088470

Iida, Yasunori; Ito, Tsutomu; Kitahara, Hiroto; Takebe, Motojiro; Nemoto, Atsushi; Shimokawa, Reiko; Yoshitake, Akihiro; Misumi, Takahiko



[Viral hepatitis].  


Viral hepatitis is associated with significant morbidity and mortality worldwide. Hepatitis A and E viruses are enterally transmitted and lead to usually self-limited acute hepatitis. Hepatitis B, C and D viruses are transmitted by parenteral routes and can lead to chronic hepatitis with progression to liver cirrhosis and hepatocellular carcinoma. Here, we briefly review current understanding and new developments in the virology and epidemiology, diagnosis, natural history, therapy and prevention of viral hepatitis. PMID:21452137

Moradpour, Darius; Blum, Hubert E



Mortality in a cohort of radiation treated childhood skin hemangiomas.  


Mortality was studied in 18,357 patients (33% males and 67% females) with skin hemangioma admitted to Radiumhemmet between 1920 and 1959. The treatments of the hemangiomas were performed by radium-226 sources (13,094 patients) or x-ray therapy (2,540 patients). In 2,723 patients no radiotherapy was given. The median age was 6 months for the treated patients and 8 months for the patients not receiving radiotherapy. Between 1920 and 1951 a total of 154 patients were reported dead. The cohort was matched with the Swedish Cause of Death Register between 1952 and 1985. During that period 504 died, in 146 patients the cause of death was cancer or leukemia. The total number of person-years at risk was 587,426. In patients treated with radium-226 or orthovoltage x-rays, 410 deaths occurred (standardized mortality ratio (SMR) = 1.07; ns). In patients given contact therapy 34 deaths occurred (SMR = 0.82; ns) and in the not irradiated group 60 deaths occurred (SMR = 0.78; ns). Patients treated with radium-226 or orthovoltage x-rays had an SMR of 1.34 for all cancers combined (p less than 0.05). For patients treated between 1920 and 1939 the SMR for cancer was 1.53 (p less than 0.05) as compared to an SMR of 1.16 (ns) for those treated between 1940 and 1959. PMID:2611031

Fürst, C J; Silfverswärd, C; Holm, L E



Sub-Tenon's Steroid Irrigation for Treatment of Intraorbital Capillary Hemangioma  

PubMed Central

Summary A four-month-old male infant underwent sub-Tenon's steroid irrigation for treatment of orbital capilary hemangioma that was causing exposure keratopathy risk to the left eye from progressive proptosis. The temporal inferior sub-Tenon's space was irrigated with a mixture of triamcinolone acetonide (40 mg/ml) and betamethasone sodium phosphate (6 mg/ml) by a blunt-tipped sub-Tenon's cannula. We describe this procedure as irrigation because reflux of the mixture from the incision was permitted. Two weeks after treatment, a marked reduction of proptosis was noted. One month after treatment, the volume of the intraorbital hemangioma resolved significantly in MRI examination. Steroid treatment can be applied local or systemically to treat orbital capillary hemangioma but side effects must be considered carefully. Sub-Tenon's steroid irrigation may be a benefical, effective, pratical and safe application route in the treatment of orbital capillary hemangiomas.

Firat, P.G.; Doganay, S.; Bilak, S.; Alkan, A.



Multilevel vertebral hemangiomas: two episodes of spinal cord compression at separate levels 10 years apart  

Microsoft Academic Search

This case report presents a 66-year-old woman with multiple vertebral hemangiomas causing spinal cord compression at different levels with a long symptom-free interval between episodes of compression. She presented with back pain and progressive weakness and numbness in her lower limbs for 3 months. Ten years earlier, she had had a symptomatic T4 vertebral hemangioma operated successfully, and had made a

Oguz Karaeminogullari; Cengiz Tuncay; Huseyin Demirors; Kayihan Akin; Orcun Sahin; Ayhan Ozyurek; Nevzat Reha Tandogan



Supratentorial Convexity Dural-Based Cavernous Hemangioma Mimicking a Meningioma in a Child  

Microsoft Academic Search

A case of a convexity dural-based cavernous hemangioma in a 15-year-old male child is reported. The child presented only with headaches and had no neurological deficits. MRI features were suggestive of a meningioma. The tumor was completely resected and histology was conclusive of a hemangioma. At follow-up after 2 years, the child is asymptomatic and MRI showed no evidence of

V. Joshi; D. Muzumdar; N. Dange; A. Goel



PHACES syndrome in association with airway hemangioma: First report from Saudi Arabia and literature review  

PubMed Central

“PHACES” is a neurocutaneous syndrome that refers to the following associations: Posterior fossa malformations, Hemangiomas, Arterial malformations, Coarctation of the aorta/Cardiac defects, Eye abnormalities, and Sternal defects. Herein, we report the association of PHACES syndrome with airway hemangioma, a serious association that should not be overlooked. The findings of such an association presented here are the first to be reported from Saudi Arabia.

Alsuwaidan, Sami N.



Management of infantile subglottic hemangioma: laser vaporization, submucous resection, intubation, or intralesional steroids?  

Microsoft Academic Search

The infantile subglottic hemangioma can be treated in various ways. The results of the treatment used in the Sophia Children’s Hospital, intralesional steroids and intubation (IS+I), are discussed and compared with the results of other current treatment methods: CO2 laser vaporization, submucous resection and intubation alone. A total of 18 infants were treated for subglottic hemangioma in our hospital: ten

L. J Hoeve; G. L. E Küppers; C. D. A Verwoerd



Successful and safe treatment of hemangioma with oral propranolol in a single institution  

PubMed Central

Purpose Dramatic improvement of hemangioma to propranolol has been recently reported; however, details on dose and duration of treatment, potential risks, and monitoring have not been determined. The objective of this study is to describe and analyze the use of propranolol as a first-line treatment or as a single therapy in management of complicated hemangioma. Methods A retrospective chart review of eight patients diagnosed with hemangioma and treated with propranolol in Kangbuk Samsung Hospital from February 2010 to April 2011 was performed. Results Eight patients with hemangioma with functional impairment, cosmetic disfigurement, or rapid growth were treated with propranolol. Five patients had solitary facial hemangioma. The mean age of symptoms at onset was 5 weeks. The median age for starting propranolol treatment was 5.5 months. Propranolol at 2 mg/kg/day was finally administered in divided doses with a gradual increase. Significant regression was observed in seven patients, and shrinkage in size, softening in consistency, and decrease in redness were evident within 4 weeks. Among them, six patients were still taking propranolol, and one patient had stopped after 12 months. Other one patient did not show significant improvement with satisfactory result after 3 months of propranolol use. Treatment with propranolol was well tolerated and had few side effects. No rebound growth was observed in any of the patients. Conclusion We observed that use of propranolol was very effective in treatment of hemangioma without obvious adverse effects or relapse.

Chung, Sun Hee; Park, Dong Hyuk; Shim, Jae Won; Kim, Deok Soo; Shim, Jung Yeon; Park, Moon Soo; Koo, Hong Hoe



Rapamycin Inhibits Proliferation of Hemangioma Endothelial Cells by Reducing HIF-1-Dependent Expression of VEGF  

PubMed Central

Hemangiomas are tumors formed by hyper-proliferation of vascular endothelial cells. This is caused by elevated vascular endothelial growth factor (VEGF) signaling through VEGF receptor 2 (VEGFR2). Here we show that elevated VEGF levels produced by hemangioma endothelial cells are reduced by the mTOR inhibitor rapamycin. mTOR activates p70S6K, which controls translation of mRNA to generate proteins such as hypoxia inducible factor-1 (HIF-1). VEGF is a known HIF-1 target gene, and our data show that VEGF levels in hemangioma endothelial cells are reduced by HIF-1? siRNA. Over-expression of HIF-1? increases VEGF levels and endothelial cell proliferation. Furthermore, both rapamycin and HIF-1? siRNA reduce proliferation of hemangioma endothelial cells. These data suggest that mTOR and HIF-1 contribute to hemangioma endothelial cell proliferation by stimulating an autocrine loop of VEGF signaling. Furthermore, mTOR and HIF-1 may be therapeutic targets for the treatment of hemangiomas.

Medici, Damian; Olsen, Bjorn R.



COSMC Is Overexpressed in Proliferating Infantile Hemangioma and Enhances Endothelial Cell Growth via VEGFR2  

PubMed Central

Infantile hemangiomas are localized lesions comprised primarily of aberrant endothelial cells. COSMC plays a crucial role in blood vessel formation and is characterized as a molecular chaperone of T-synthase which catalyzes the synthesis of T antigen (Gal?1,3GalNAc). T antigen expression is associated with tumor malignancy in many cancers. However, roles of COSMC in infantile hemangioma are still unclear. In this study, immunohistochemistry showed that COSMC was upregulated in proliferating hemangiomas compared with involuted hemangiomas. Higher levels of T antigen expression were also observed in the proliferating hemangioma. Overexpression of COSMC significantly enhanced cell growth and phosphorylation of AKT and ERK in human umbilical vein endothelial cells (HUVECs). Conversely, knockdown of COSMC with siRNA inhibited endothelial cell growth. Mechanistic investigation showed that O-glycans were present on VEGFR2 and these structures were modulated by COSMC. Furthermore, VEGFR2 degradation was delayed by COSMC overexpression and facilitated by COSMC knockdown. We also showed that COSMC was able to regulate VEGF-triggered phosphorylation of VEGFR2. Our results suggest that COSMC is a novel regulator for VEGFR2 signaling in endothelial cells and dysregulation of COSMC expression may contribute to the pathogenesis of hemangioma.

Lee, Jian-Jr; Huang, Miao-Juei; Huang, John; Hung, Ji-Shiang; Chen, Ming-Ting; Huang, Min-Chuan



Prevalence of oral hemangioma, vascular malformation and varix in a Brazilian population.  


Hemangioma, vascular malformation and varix are benign vascular lesions, common in the head and neck regions. Studies about the prevalence of these lesions in the oral cavity are scarce. The aim of this study was to estimate the prevalence of and to obtain clinical data on oral hemangioma, vascular malformation and varix in a Brazilian population. Clinical data on those lesions were retrieved from the clinical forms from the files of the Oral Diagnosis Service, School of Dentistry, Federal University of Minas Gerais, Brazil, from 1992 to 2002. Descriptive analysis was performed. A total of 2,419 clinical forms in the 10-year period were evaluated, of which 154 (6.4%) cases were categorized as oral hemangioma, oral vascular malformation or oral varix. Oral varix was the most frequent lesion (65.6%). Females had more oral hemangioma and oral varix than males. Oral vascular malformation and oral varix were more prevalent in the 7th and 6th decades, respectively. Oral hemangioma and oral varix were more prevalent in the ventral surface of the tongue and oral vascular malformation, in the lips. Oral hemangioma was treated with sclerotherapy (54.5%), and vascular malformation was managed with sclerotherapy and surgery (19.4% each). The data of this study suggests that benign vascular lesions are unusual alterations on the oral mucosa and jaws. PMID:17384854

Corrêa, Priscila Henriques; Nunes, Lara Cristina Caldeira; Johann, Aline Cristina Batista Rodrigues; Aguiar, Maria Cássia Ferreira de; Gomez, Ricardo Santiago; Mesquita, Ricardo Alves


Hemangioma of the prostate - an unusual cause of lower urinary tract symptoms: Case report  

PubMed Central

Background Hemangioma of the prostate gland is extremely rare and only a few cases have been reported. There have been several cases of hemangioma of posterior urethra, urinary bladder and periprostatic plexus in the literature, all presenting with hematuria or hematospermia. Diagnosis of prostatic hemangioma is difficult due to its rarity and unspecific symptoms such as hematuria, hematospermia or lower urinary tract symptoms. It cannot be detected by conventional examinations such as cystoscopy or standard rectal ultrasonography. Case presentation We present a case of prostatic hemangioma in an 84-year old male presenting with lower urinary tract symptoms. Bleeding has not been a feature in our case and diagnosis was not made until after operation. The patient was treated as a case of bladder neck outflow obstruction with transurethral resection of prostate gland and simultaneous bladder neck incisions. A period of self-catheterization was instituted due to postoperative urinary retention as the result of detrusor insufficiency. Conclusion Hemangioma of prostate gland is extremely rare and symptomatic prostatic hemangioma should be treated either by transurethral resection of prostate or laser evaporation.



Giant magnetoresistance: a primer  

Microsoft Academic Search

An introduction to the phenomenon of giant magnetoresistance is presented. It is pointed out that the giant magnetoresistance effect appears in a number of ultrathin multilayer systems in which thin magnetic films, a few tens of Å thick, are separated by nonmagnetic metal films, also on the order of tens of Å thick. For the effect to appear, the primary

R. L. White



Giant fields of Venezuela  

Microsoft Academic Search

Only 44 out of the nearly 300 oil fields discovered in Venezuela to the end of 1965 could be classified as giants, i.e., fields having resource of at least 100 million bbl of oil. Giant fields have been discovered in three of the sedimentary basins of the country. The average time lag for the recognition of an oil field as



Giant Steps in Cefalù  

NASA Astrophysics Data System (ADS)

Giant steps is a technique to accelerate Monte Carlo radiative transfer in optically-thick cells (which are isotropic and homogeneous in matter properties and into which astrophysical atmospheres are divided) by greatly reducing the number of Monte Carlo steps needed to propagate photon packets through such cells. In an optically-thick cell, packets starting from any point (which can be regarded a point source) well away from the cell wall act essentially as packets diffusing from the point source in an infinite, isotropic, homogeneous atmosphere. One can replace many ordinary Monte Carlo steps that a packet diffusing from the point source takes by a randomly directed giant step whose length is slightly less than the distance to the nearest cell wall point from the point source. The giant step is assigned a time duration equal to the time for the RMS radius for a burst of packets diffusing from the point source to have reached the giant step length. We call assigning giant-step time durations this way RMS-radius (RMSR) synchronization. Propagating packets by series of giant steps in giant-steps random walks in the interiors of optically-thick cells constitutes the technique of giant steps. Giant steps effectively replaces the exact diffusion treatment of ordinary Monte Carlo radiative transfer in optically-thick cells by an approximate diffusion treatment. In this paper, we describe the basic idea of giant steps and report demonstration giant-steps flux calculations for the grey atmosphere. Speed-up factors of order 100 are obtained relative to ordinary Monte Carlo radiative transfer. In practical applications, speed-up factors of order ten and perhaps more are possible. The speed-up factor is likely to be significantly application-dependent and there is a trade-off between speed-up and accuracy. This paper and past work suggest that giant-steps error can probably be kept to a few percent by using sufficiently large boundary-layer optical depths while still maintaining large speed-up factors. Thus, giant steps can be characterized as a moderate accuracy radiative transfer technique. For many applications, the loss of some accuracy may be a tolerable price to pay for the speed-ups gained by using giant steps.

Jeffery, David J.; Mazzali, Paolo A.



Peripheral giant cell granuloma  

PubMed Central

Peripheral giant cell granuloma or the so-called “giant cell epulis” is the most common oral giant cell lesion. It normally presents as a soft tissue purplish-red nodule consisting of multinucleated giant cells in a background of mononuclear stromal cells and extravasated red blood cells. This lesion probably does not represent a true neoplasm, but rather may be reactive in nature, believed to be stimulated by local irritation or trauma, but the cause is not certainly known. This article reports a case of peripheral giant cell granuloma arising at the maxillary anterior region in a 22-year-old female patient. The lesion was completely excised to the periosteum level and there is no residual or recurrent swelling or bony defect apparent in the area of biopsy after a follow-up period of 6 months.

Tandon, Padam Narayan; Gupta, S. K.; Gupta, Durga Shanker; Jurel, Sunit Kumar; Saraswat, Abhishek



Propranolol treatment of infantile hemangioma endothelial cells: A molecular analysis.  


Infantile hemangiomas (IHs) are non-malignant, largely cutaneous vascular tumors affecting approximately 5-10% of children to varying degrees. During the first year of life, these tumors are strongly proliferative, reaching an average size ranging from 2 to 20 cm. These lesions subsequently stabilize, undergo a spontaneous slow involution and are fully regressed by 5 to 10 years of age. Systemic treatment of infants with the non-selective ?-adrenergic receptor blocker, propranolol, has demonstrated remarkable efficacy in reducing the size and appearance of IHs. However, the mechanism by which this occurs is largely unknown. In this study, we sought to understand the molecular mechanisms underlying the effectiveness of ? blocker treatment in IHs. Our data reveal that propranolol treatment of IH endothelial cells, as well as a panel of normal primary endothelial cells, blocks endothelial cell proliferation, migration, and formation of the actin cytoskeleton coincident with alterations in vascular endothelial growth factor receptor-2 (VEGFR-2), p38 and cofilin signaling. Moreover, propranolol induces major alterations in the protein levels of key cyclins and cyclin-dependent kinase inhibitors, and modulates global gene expression patterns with a particular affect on genes involved in lipid/sterol metabolism, cell cycle regulation, angiogenesis and ubiquitination. Interestingly, the effects of propranolol were endothelial cell-type independent, affecting the properties of IH endothelial cells at similar levels to that observed in neonatal dermal microvascular and coronary artery endothelial cells. This data suggests that while propranolol markedly inhibits hemangioma and normal endothelial cell function, its lack of endothelial cell specificity hints that the efficacy of this drug in the treatment of IHs may be more complex than simply blockage of endothelial function as previously believed. PMID:23170111

Stiles, Jessica; Amaya, Clarissa; Pham, Robert; Rowntree, Rebecca K; Lacaze, Mary; Mulne, Arlynn; Bischoff, Joyce; Kokta, Victor; Boucheron, Laura E; Mitchell, Dianne C; Bryan, Brad A



Unstable giant gravitons  

NASA Astrophysics Data System (ADS)

We find giant graviton solutions in Frolov’s three parameter generalization of the Lunin-Maldacena background. The background we study has ?˜1=0 and ?˜2=?˜3=?˜. This class of backgrounds provides a nonsupersymmetric example of the gauge theory/gravity correspondence that can be tested quantitatively, as recently shown by Frolov, Roiban, and Tseytlin. The giant graviton solutions we find have a greater energy than the point gravitons, making them unstable states. Despite this, we find striking quantitative agreement between the gauge theory and gravity descriptions of open strings attached to the giant.

de Mello Koch, Robert; Ives, Norman; Smolic, Jelena; Smolic, Milena



Unstable giant gravitons  

SciTech Connect

We find giant graviton solutions in Frolov's three parameter generalization of the Lunin-Maldacena background. The background we study has {gamma}-tilde{sub 1}=0 and {gamma}-tilde{sub 2}={gamma}-tilde{sub 3}={gamma}-tilde. This class of backgrounds provides a nonsupersymmetric example of the gauge theory/gravity correspondence that can be tested quantitatively, as recently shown by Frolov, Roiban, and Tseytlin. The giant graviton solutions we find have a greater energy than the point gravitons, making them unstable states. Despite this, we find striking quantitative agreement between the gauge theory and gravity descriptions of open strings attached to the giant.

Mello Koch, Robert de [Department of Physics and Centre for Theoretical Physics, University of the Witwatersrand, Wits, 2050 (South Africa); Stellenbosch Institute for Advanced Studies, Stellenbosch (South Africa); Ives, Norman; Smolic, Jelena; Smolic, Milena [Department of Physics and Centre for Theoretical Physics, University of the Witwatersrand, Wits, 2050 (South Africa)



Severe progressive scoliosis due to huge subcutaneous cavernous hemangioma: A case report  

PubMed Central

Cavernous hemangioma consists mainly of congenital vascular malformations present before birth and gradually increasing in size with skeletal growth. A small number of patients with cavernous hemangioma develop scoliosis, and surgical treatment for the scoliosis in such cases has not been reported to date. Here we report a 12-year-old male patient with severe progressive scoliosis due to a huge subcutaneous cavernous hemangioma, who underwent posterior correction and fusion surgery. Upon referral to our department, radiographs revealed a scoliosis of 85° at T6-L1 and a kyphosis of 58° at T4-T10. CT and MR images revealed a huge hemangioma extending from the subcutaneous region to the paraspinal muscles and the retroperitoneal space and invading the spinal canal. Posterior correction and fusion surgery using pedicle screws between T2 and L3 were performed. Massive hemorrhage from the hemangioma occurred during the surgery, with intraoperative blood loss reaching 2800 ml. The scoliosis was corrected to 59°, and the kyphosis to 45° after surgery. Seven hours after surgery, the patient suffered from hypovolemic shock and disseminated intravascular coagulation due to postoperative hemorrhage from the hemangioma. The patient developed sensory and conduction aphasia caused by cerebral hypoxia during the shock on the day of the surgery. At present, two years after the surgery, although the patient has completely recovered from the aphasia. This case illustrates that, in correction surgery for scoliosis due to huge subcutaneous cavernous hemangioma, intraoperative and postoperative intensive care for hemodynamics should be performed, since massive hemorrhage can occur during the postoperative period as well as the intraoperative period.



Hepatitis A  


... has hepatitis A Receive clotting-factor concentrates for hemophilia or another medical condition Complications Continuing signs and ... and symptoms as part of making a diagnosis. Treatments and drugs No specific treatment exists for hepatitis ...


Toxic Hepatitis  


... may be reprinted for personal, noncommercial use only. Toxic hepatitis By Mayo Clinic staff Original Article: Definition Symptoms Causes Risk factors Complications ...


The Giant Cell.  

ERIC Educational Resources Information Center

|Provides directions for the construction of giant plastic cells, including details for building and installing the organelles. Also contains instructions for preparing the ribosomes, nucleolus, nucleus, and mitochondria. (DDR)|

Stockdale, Dennis



A giant panda  

NSDL National Science Digital Library

The giant panda is endangered because of habitat loss and low birth rates in the wild and captivity. In the past, poaching also lowered the numbers of surviving pandas and they became listed as an endangered species.

Aaron Siirila (None;)



Viral Hepatitis  

Microsoft Academic Search

Various forms of viral hepatitis have been identified as being sexually transmitted infections (STIs), whereas other forms\\u000a are transmitted primarily via oralfecal routes. The most common forms of viral hepatitis are hepatitis A, B, and C. Hepatitis\\u000a A virus (HAV) infection is most often a benign self-limiting disease; however, it can progress to fulminant liver failure.\\u000a Fecal-oral transmission though contact

Michelle L. Geller; Jeremy R. Herman


Hepatitis A  


... of hepatitis - a liver disease - caused by the hepatitis A virus (HAV). The disease is spread primarily through food or water contaminated by stool from an infected person. You can get HAV ... several weeks. The hepatitis A vaccine can prevent HAV. Healthy habits also ...


Red giant seismology: Observations  

NASA Astrophysics Data System (ADS)

The CoRoT and Kepler missions provide us with thousands of red-giant light curves that allow a very precise asteroseismic study of these objects. Before CoRoT and Kepler, the red-giant oscillation patterns remained obscure. Now, these spectra are much more clear and unveil many crucial interior structure properties. For thousands of red giants, we can derive from seismic data precise estimates of the stellar mass and radius, the evolutionary status of the giants (with a clear difference between clump and RGB stars), the internal differential rotation, the mass loss, the distance of the stars... Analyzing this amount of information is made easy by the identification of the largely homologous red-giant oscillation patterns. For the first time, both pressure and mixed mode oscillation patterns can be precisely depicted. The mixed-mode analysis allows us, for instance, to probe directly the stellar core. Fine details completing the red-giant oscillation pattern then provide further information on the interior structure, including differential rotation.

Mosser, B.



Riboflavin and Mouse Hepatic Cell Structure and Function. Mitochondrial Oxidative Metabolism in Severe Deficiency States1  

Microsoft Academic Search

Weanling mice were fed a riboflavin-deficient diet or the same diet with added galactoflavin. Both diets produced changes in hepatic mitochondrial mor phology, the most striking of which was the development of giant mitochondria. The livers from these animals were fractionated, and the nuclear and mitochondrial fractions were examined by electron microscopy. The nuclear fraction contained giant mito chondria; the



Synovial hemangioma of the knee joint in a 12-year-old boy: a case report  

PubMed Central

Introduction Synovial hemangioma is a rare condition and is frequently misdiagnosed, leading to a diagnostic delay of many years. Case presentation We present a case of an atypical synovial hemangioma in a 12-year-old Caucasian boy with a diagnostic delay of 3 years. Conclusion It is important to know that synovial hemangioma mostly affects the knee joint, showing recurrent bloody effusions without a history of trauma. If there are no intermittent effusions, the diagnosis will be even more difficult. In cases of nonspecific symptoms and longstanding knee pain the diagnosis of a synovial hemangioma should also be considered in order to avoid diagnostic delay. Magnetic resonance imaging is the main diagnostic tool to evaluate patients with synovial hemangioma, showing characteristic lace-like or linear patterns. Angiography can identify feeder vessels and offers the possibility of embolisation in the same setting. Surgical excision, either done per arthroscopy or per arthrotomy, is recommended as soon as possible to avoid the risk of damage to the cartilage.



Spinal capillary hemangioma in infants: report of two cases and review of the literature.  


We report the case of 2 infants born with a lumbar dermal sinus tract and an overlying angiomatous skin lesion referred to our pediatric neurosurgery service for evaluation of a tethered cord. Both infants were born with a lumbar dimple and were found to have a large cutaneous hemangioma without neurologic symptoms. An MRI of the lumbar spine revealed an isointense mass in the dorsal epidural at L(4) with an adjacent mass effect and extension into the overlying soft tissues. The spinal cord also appeared to be tethered with a fatty filum terminale. We performed a lumbar laminectomy and laminoplasty to remove the mass and to release the tethered cord. Pathologic examination confirmed the diagnosis of capillary hemangioma. Several case reports describe spinal capillary hemangiomas in adults, but only one found in the literature describes a case in an infant. We provide a review of the literature of spinal capillary hemangiomas and support the practice of evaluating infants with cutaneous lumbosacral hemangiomas for underlying spinal cord abnormalities. PMID:17337925

Karikari, Isaac O; Selznick, Lee A; Cummings, Thomas J; George, Timothy M



Cellular markers that distinguish the phases of hemangioma during infancy and childhood.  

PubMed Central

Hemangiomas, localized tumors of blood vessels, appear in approximately 10-12% of Caucasian infants. These lesions are characterized by a rapid proliferation of capillaries for the first year (proliferating phase), followed by slow, inevitable, regression of the tumor over the ensuing 1-5 yr (involuting phase), and continual improvement until 6-12 yr of age (involuted phase). To delineate the clinically observed growth phases of hemangiomas at a cellular level, we undertook an immunohistochemical analysis using nine independent markers. The proliferating phase was defined by high expression of proliferating cell nuclear antigen, type IV collagenase, and vascular endothelial growth factor. Elevated expression of the tissue inhibitor of metalloproteinase, TIMP 1, an inhibitor of new blood vessel formation, was observed exclusively in the involuting phase. High expression of basic fibroblast growth factor (bFGF) and urokinase was present in the proliferating and involuting phases. There was coexpression of bFGF and endothelial phenotypic markers CD31 and von Willebrand factor in the proliferating phase. These results provide an objective basis for staging hemangiomas and may be used to evaluate pharmacological agents, such as corticosteroids and interferon alfa-2a, which accelerate regression of hemangiomas. By contrast, vascular malformations do not express proliferating cell nuclear antigen, vascular endothelial growth factor, bFGF, type IV collagenase, and urokinase. These data demonstrate immunohistochemical differences between proliferating hemangiomas and vascular malformations which reflect the biological distinctions between these vascular lesions. Images

Takahashi, K; Mulliken, J B; Kozakewich, H P; Rogers, R A; Folkman, J; Ezekowitz, R A



A case of congenital giant gallbladder with massive hydrops mimicking celiac cyst  

PubMed Central

We present a case of a 55-year-old female who suffered from a mass in the right upper abdomen, which had been present for over six months. Pre-operative blood examinations, including tumor markers, were normal. Initially, the admitting diagnosis was a giant celiac cyst, due to its liquid cystic appearance and large size (approximately 30.0×18.0 cm), visible in the hepatic region under ultrasound. Following the discovery of a cystic duct during surgery, the diagnosis was corrected to be a giant gallbladder. As no obstructive matter was observed, the giant gallbladder was considered to be congenital.




Social isolation in parents of children with hemangiomas: Effects of coping styles and emotional distress.  


This study investigated factors associated with social isolation in parents of children with hemangiomas. Eighty-one parents completed questionnaires assessing their emotional distress, social isolation, and coping styles. To explore the relationships between these variables, a path analysis was used to test a model in which clinical characteristics of hemangiomas and parents' coping strategies do not have direct effects on their social isolation but indirect effects via their emotional distress. Bootstrapping was used to assess indirect effects. Time since onset and lesional complications had positive direct effects on parents' social isolation. Lesional visibility and emotion-focused coping had negative indirect effects on parents' social isolation via their emotional distress, while problem-focused coping showed a positive indirect effect. These findings may have implications for clinicians managing parents of children with hemangiomas. PMID:23387298

Quintard, Bruno; Gana, Kamel; Constant, Aymery; Quintric, Chantal; Taïeb, Alain; Léauté-Labrèze, Christine



Clinical characteristics and outcomes of primary adrenal hemangioma in a dog.  


An 8-year-old 7.9 kg castrated male Shih-tzu dog was presented to surgery with polyuria-polydipsia, intermittent abdominal pain and dermatological problems. The unilateral enlargement of the right adrenal gland was observed through ultrasound examination and based on this examination a hyperadrenocorticism was suspected. Upon physical examination, regional erythema was observed in the skin. An abdominal CT scan showed a well-defined retroperitoneal mass. Adrenalectomy via a midline abdominal approach was performed as well as optional treatments upon the approval of the owners. The histopathological diagnosis was that of an adrenal hemangioma without evidence of malignancy. Adrenal hemangioma was incidentally found in this dog during histological examination and this finding was an extremely rare case of the primary hemangioma in the adrenal gland. PMID:23706763

Lee, Hee-Chun; Jung, Dong-In; Moon, Jong-Hyun; Kim, Na-Hyun; Lee, Jae-Hoon



Co-occurrence of intraoral hemangioma and port wine stain: A rare case  

PubMed Central

Hemangiomas are neoplastic proliferations of endothelial cells, characterized by a period of growth after birth, and eventual spontaneous involution. The course can be uneventful with spontaneous resolution; or it may be marked by complications such as infection, bleeding, ulceration, visual defects and feeding difficulties. Apart from these, rare life-threatening complications such as congestive heart failure and consumption coagulopathy may also be seen. Although hemangiomas commonly occur in the head and neck region, intraoral occurrence is relatively rare. A port wine stain is defined as a macular telangiectatic patch which is present at birth and remains throughout life. They may be localized or extensive, affecting a whole limb. This article reports a rare case of co-occurrence of port wine stain with intraoral hemangioma.

Rao, Prasanna Kumar; Bejai, Vishal; Rao, Sanath; Shetty, Shishir Ram



Giant resonances: reaction theory approach.  

National Technical Information Service (NTIS)

The study of giant resonances through the use of reaction theory approach is presented and discussed. Measurements of cross-sections to the many available decay channels following excitation of giant multipole resonances (GMR) led one to view these phenom...

A. F. R. Toledo Piza G. A. Foglia



Giant Cell Tumor of Bone  


Copyright 2010 American Academy of Orthopaedic Surgeons Giant Cell Tumor of Bone Giant cell tumor of bone (GCT) is a rare, aggressive non-cancerous (benign) tumor. It generally occurs in adults between the ages of ...


Breast cancer after radiotherapy for skin hemangioma in infancy  

SciTech Connect

Between 1920 and 1959, 9675 women were irradiated in infancy for skin hemangioma at Radiumhemmet, Stockholm. They were exposed to low to moderate doses of ionizing radiation. The mean age at first exposure was 6 months and the mean absorbed dose to the breast anlage was 0.39 Gy (range < 0.01-35.8 Gy). The breast cancer incidence was analyzed by record linkage with the Swedish Cancer Register for the period 1958-1986. Seventy-five breast cancers were found after a mean absorbed dose of 1.5 Gy in the breasts with cancer. The analyses showed a significant dose-response relationship with a linear model estimate for the excess relative risk (ERR) of 0.38 at 1 Gy (95% CI 0.09-0.85). This relationship was not modified significantly by age at exposure or by dose to the ovaries. The ERR increased significantly with time after exposure and for > 50 years after exposure the ERR at 1 Gy was 2.25 (95% CI 0.59-5.62). The fitted excess absolute risk (EAR) was 22.9 per 10{sup 4} breast-year gray. The breast absorbed dose and time after exposure were important risk determinants for breast cancer excess risk. Forty to 50 years of follow-up was necessary for the excess risk to be expressed. The study confirms previous findings that the breast anlage of female infants is sensitive to ionizing radiation. 17 refs., 6 figs.

Lundell, M.; Mattsson, A.; Hakulinen, T.; Holm, L.E. [Karolinska Hospital, Stockholm (Sweden)



Viral hepatitis*  

PubMed Central

Three forms of viral hepatitis can be recognized: hepatitis A, hepatitis B, and hepatitis non-A, non-B. Hepatitis A is caused by a picornavirus, is transmitted by the faceal—oral route, does not become chronic, and no chronic virus carriers exist. The virus can be grown in cell cultures, and killed as well as live attenuated virus vaccines are under development. Hepatitis B is caused by an enveloped virus containing a circular, double-stranded form of DNA. The disease is transmitted parenterally through inoculation of blood or blood products containing virus or through close personal contact with a virus-positive person. Hepatitis B becomes chronic in a certain number of cases and can lead to cirrhosis and primary liver cell carcinoma. The blood and certain body secretions of individuals with a persistent or chronic infection may remain infectious for many years. The hepatitis B virus cannot be grown in cell cultures but the entire genome has been sequenced and cloned in bacterial and eukaryotic cells. An inactivated virus vaccine has been prepared from hepatitis B surface antigen present in the plasma of hepatitis B virus carriers and further vaccines are under development. The agents of hepatitis non-A, non-B have not been identified. It is possible to distinguish between a predominantly parenterally transmitted and an orally transmitted form of hepatitis non-A, non-B. The latter is reported to be caused by a picornavirus that does not, however, have any antigenic relationship with hepatitis A virus.

Deinhardt, F.; Gust, I. D.



Diagnosis and management of hepatic focal nodular hyperplasia  

PubMed Central

Focal nodular hyperplasia (FNH) is the second most common benign tumor of the liver, after hemangioma. It is generally found incidentally and is most common in reproductive-aged women, but it also affects males and can be diagnosed at any age. Patients are rarely symptomatic, but FNH sometimes causes epigastric or right upper quadrant pain. The main clinical task is to differentiate it from other hypervascular hepatic lesions such as hepatic adenoma, hepatocellular carcinoma, or hypervascular metastases, but invasive diagnostic procedures can generally be avoided with the appropriate use of imaging techniques. Magnetic resonance (MR) imaging is more sensitive and specific than conventional ultrasonography (US) or computed tomography (CT), but Doppler US and contrast-enhanced US (CEUS) can greatly improve the accuracy in the diagnosis of FNH. Once a correct diagnosis has been made, in most cases there is no indication for surgery, and treatment includes conservative clinical follow-up in asymptomatic patients.

Venturi, A.; Piscaglia, F.; Vidili, G.; Flori, S.; Righini, R.; Golfieri, R.; Bolondi, L.



Generalized enchondromatosis with unusual complications of soft tissue calcifications and hemangiomas  

SciTech Connect

Generalized enchondromatosis is a newly delineated type of enchondromatosis. Radiographically there are multiple enchondromata in almost all metaphyses of the long and short tubular bones and the lesions are in almost the same stage of development with mild platyspondyly and skull deformity. The pelvic changes are characteristic and, together with the metaphyseal changes of the long and short tubular bones, are probably diagnostic of this disorder. The present case demonstrates advanced radiographic features of this disorder associated with unusual soft tissue calcifications and hemangiomas. The presence of hemangiomas in our case as well as three cases in the literature suggests this feature is more than a coincidence.

Kaibara, N.; Katsuki, I.; Hotokebuchi, T.; Takagishi, K.; Mitsuyasu, M.



[Sclerosing hemangioma of the lung: a rare lesion with a difficult diagnosis].  


Sclerosing hemangioma of the lung is a rare lesion described for the first time in 1956 by Liebow. We report a case in a 45 year-old woman who was admitted for exploration of chronic cough. The chest x-ray revealed a round opacity, well delimited in the left pulmonary parenchyma. Surgical resection enabled the histopathological diagnosis of sclerosing hemangioma. We review progress in our knowledge of the histogenesis and diagnosis of this tumor. Immunohistochemistry has been highly contributory although numerous points remain controversial. PMID:17242645

Bougrine, F; Chouchane, O; Doghri, R; Znaidi, N; Hchicha, S; Sakhri, A; Laabidi, B; Cheikh, R; Chnik, S; Bouziani, A



Multiple cavernous hemangiomas of the lung: a case report and review of the literature.  


Cavernous hemangiomas are benign vascular tumors most commonly seen in the head and neck region in childhood. They have been described rarely in the lungs. We describe a patient with incidental pulmonary nodules discovered at autopsy, which measured up to 0.9 cm and which were present in the lung parenchyma, as well as on the pleura. The nodules were composed of dilated vascular spaces lined by flattened bland cells. Immunohistochemical studies of the lining cells revealed CD34 and factor VIII immunoreactivity, consistent with a lesion of endothelial origin. Taken together, the gross, microscopic, and immunohistochemical findings support the diagnosis of multiple pulmonary cavernous hemangiomas. PMID:15578892

Fine, Samson W; Whitney, Kathleen D



Hemangioma of the Tympanic Membrane: A Case and a Review of the Literature  

PubMed Central

Hemangiomas of the external auditory canal, involving the posterior bony canal and the adjacent tympanic membrane, although rare, are considered a specific disease entity of the human external auditory canal. Hemangiomas of the tympanic membrane and/or external auditory canal are rare entities; there are 16 previous case reports in the literature. It is a benign vascular tumor. It generally occurs in males in the sixth decade of life. Total surgical excision with or without tympanic membrane grafting appears to be effective in the removal of this benign neoplasm. The authors present a case and a review of the literature discussing diagnostic and surgical approaches.

Mevio, Emilio; Cazzaniga, Marco; Mullace, Mauro; Paolotti, Donatella



The risk of spontaneous rupture of liver hemangiomas: a critical review of the literature  

Microsoft Academic Search

Background  The risk of spontaneous bleeding or rupture of liver hemangiomas still remains unknown. The aim of this review was to analyze\\u000a the problem of spontaneous bleeding or rupture in liver hemangiomas and to identify factors leading to bleeding in these cases.\\u000a \\u000a \\u000a \\u000a \\u000a Methods  A MEDLINE search was undertaken to identify articles in English, French, German, Italian, and Spanish from 1898 to 2010.

Marcello DonatiGregor; Gregor A. Stavrou; Angelo Donati; Karl J. Oldhafer


Giant duodenal ulcer  

PubMed Central

Twenty-five cases of benign giant duodenal ulcer have been studied. In every case a barium meal examination showed an ulcer crater with a radiographic diameter of at least 2 centimetres. Abdominal pain was the commonest symptom but less than half of the patients had had pain characteristic of chronic peptic ulcer. Haemorrhage from the ulcer occurred in a large majority of them. The radiological appearances are described, and it has been shown that the giant ulcer may be missed through being mistaken for the duodenal cap or else misdiagnosed. It appears that the death rate in this condition has been falling but it is still high. The management of patients with giant ulcers is discussed. ImagesFig. 1Fig. 2Fig. 3Fig. 4Fig. 5Fig. 6

Lumsden, K.; MacLarnon, J. C.; Dawson, J.



A giant graviton genealogy  

NASA Astrophysics Data System (ADS)

In this article we extend the construction of giant gravitons from holomorphic surfaces [1] to the ABJM correspondence. We construct a new class of M5-branes wrapping 5-manifolds in and supported by a large angular momentum in the orbifold space. These orbifold giant gravitons undergo a supersymmetry enhancement to and configurations in special cases. The compactification of M-theory on to type IIA superstring theory on then gives rise to another new class of D4 and NS5-branes wrapping 4 and 5-manifolds in . The D4-branes carry a combination of D0-brane charge and angular momentum in the complex projective space, while the NS5-branes are supported only by D0-brane charge. Finally, we present a detailed analysis of a one-parameter family of M5-brane orbifold giant gravitons, and their D4 and NS5-brane descendants.

Lozano, Yolanda; Murugan, Jeff; Prinsloo, Andrea



Vulnerability of Tasmanian giant trees  

Microsoft Academic Search

Summary Tasmania's giant trees are among the world's tallest flowering plants and Australia's greatest eucalypts. However, they are not well protected in National Parks or extensive reserves. Of the 69 known trees that meet the official criteria for protection as giants, almost 90% are in State forests managed for wood harvesting. Several of the giants are within coupes that were

Walter Herrmann


Formation of Giant Planets  

NASA Astrophysics Data System (ADS)

The observed properties of giant planets, models of their evolution, and observations of protoplanetary disks provide constraints on the formation of gas giant planets. The four largest planets in our solar system contain considerable quantities of hydrogen and helium; these gases could not have condensed into solid planetesimals within the protoplanetary disk. Jupiter and Saturn are mostly hydrogen and helium, but have larger abundances of heavier elements than does the Sun. Neptune and Uranus are primarily composed of heavier elements. The transiting extrasolar planet HD149026b, which is slightly more massive than Saturn, appears to have comparable amounts of light gases and heavy elements. The other observed transiting exoplanets are primarily hydrogen and helium, but may contain supersolar abundances of heavy elements. Spacecraft flybys and observations of satellite orbits provide estimates of the gravitational moments of the giant planets in our solar system, which in turn provide information on the internal distribution of matter within Jupiter, Saturn, Uranus, and Neptune. Atmospheric thermal structure and heat flow measurements constrain the interior temperatures of these planets. Internal processes may cause giant planets to become more compositionally differentiated or alternatively more homogeneous; high-pressure laboratory experiments provide data useful for modeling these processes. The preponderance of evidence supports the core nucleated gas accretion model. According to this model, giant planets begin their growth by the accumulation of small solid bodies, as do terrestrial planets. However, unlike terrestrial planets, the giant planet cores grow massive enough to accumulate substantial amounts of gas before the protoplanetary disk dissipates. The primary question regarding the core nucleated growth model is under what conditions can planets develop cores sufficiently massive to accrete gas envelopes within the lifetimes of gaseous protoplanetary disks.

Lissauer, J. J.; Stevenson, D. J.


Giant resonance decay  

SciTech Connect

Decay studies of giant multipole resonances are discussed, emphasizing the role of Coulomb excitation with intermediate energy heavy ions, which can provide very large cross sections for both isoscalar and isovector resonances. We discuss measurement of the photon decay of one and two phonon giant resonances, reporting results where available. It is pointed out throughout the presentation that the use of E1 photons as a tag'' provides a means to observe weakly excited resonances that cannot be observed in the singles spectra. 30 refs., 16 figs., 1 tab.

Beene, J.R.; Bertrand, F.E.




PubMed Central

A 53-year-old male presented with a giant cutaneous horn over the left leg. Cutaneous horn was excised and primary closure of the defect was done under spinal anesthesia. Histopathology showed underlying seborrheic keratosis. Cutaneous horn has been noticed on top of many clinical conditions of diverse etiology, such as actinic keratoses, wart, molluscum contagiosum, seborrheic keratoses, keratoacanthoma, basal cell and squamous cell carcinoma. We report a patient with giant cutaneous horn on the leg successfully treated by excision and wound closure.

Kumaresan, M; Kumar, Pramod; Pai, Manohar Varadharaj



How giant planets cool  

NASA Astrophysics Data System (ADS)

Understanding how giant planets cool is key to the study of their interior structure, composition and hence formation. I will review how the observed luminosities of Jupiter, Saturn, Uranus and Neptune may be accounted for, mostly by convective transport of heat limited by the atmospheric lip, but with several complications (sedimentation of helium droplets, gradients of composition...). Conversely, I will show that the the cooling of strongly irradiated giant planets ("Pegasids") is limited by heat transport in a thick external radiative zone with a possibility of a significant dissipation of heat due to tides. In all cases, both radiative transport and atmospheric/interior dynamics play crucial roles and require further studies.

Guillot, T.



Urticaria and periorbital edema as prodromal presenting signs of acute hepatitis B infection.  


A 34-year-old patient presented with giant, transient urticarial skin lesions and periorbital edema after a 3-month stay in DR Congo. Retrospective analysis of stored samples revealed that these signs were prodromal manifestations of acute hepatitis B infection. The hepatitis B infection was spontaneously cleared; the skin lesion did not recur. PMID:21539670

van Aalsburg, Rob; de Pagter, Anne P J; van Genderen, Perry J



Gigantic Cavernous Hemangioma of the Liver Treated by Intra-Arterial Embolization with Pingyangmycin-Lipiodol Emulsion: A Multi-Center Study  

SciTech Connect

Purpose: To evaluate the therapeutic effect and safety of pingyangmycin-lipiodol emulsion (PLE) intra-arterial embolization for treating gigantic cavernous hemangioma of the liver (CHL).Methods: Three hospitals (Nanfang Hospital, Inner Mongolia Autonomous Region's Hospital and Huai He Hospital) participated in the study during 1997-2001. A total of 98 patients with CHL were embolized with PLE via the hepatic artery. The therapeutic effects including changes in tumor diameter, symptomatic improvement and occurrence of complications were evaluated for a period of 12 months after the procedure.Results: The tumor diameters decreased significantly from 9.7 {+-} 2.3 cm to 5.6 {+-} 1.6 cm 6 months after the treatment (P < 0.01), and then to 3.0 {+-} 1.2 cm at 12 months (P < 0.01). Transient impairment of liver function was found in 77 cases after embolization, 69 cases of which returned to normal in 2 weeks, and the other eight cases of which recovered 1 month later. The clinical symptoms were significantly relieved in all 53 symptomatic patients. Persistent pain in the hepatic region was found in two cases, and these two patients resorted to surgery eventually.Conclusion: Intra-arterial PLE embolization proves to be effective and safe in treating patients with CHL.

Zeng Qingle; Li Yanhao; Chen Yong [Nanfang Hospital, Department of Interventional Radiology (China); Ouyang Yong [Inner Mongolia Autonomous Region's Hospital, Department of Interventional Radiology (China); He Xiang; Zhang Heping [Huai He Hospital, Department of Interventional Radiology (China)



Finite size giant magnon  

SciTech Connect

The quantization of the giant magnon away from the infinite size limit is discussed. We argue that this quantization inevitably leads to string theory on a Z{sub M} orbifold of S{sup 5}. This is shown explicitly and examined in detail in the near plane-wave limit.

Ramadanovic, Bojan; Semenoff, Gordon W. [Department of Physics and Astronomy, University of British Columbia, Vancouver, British Columbia, V6T 1Z1 (Canada)



Giant duodenal ulcers  

Microsoft Academic Search

Giant duodenal ulcers (GDU) have been associated with a high incidence of morbidity and mortality unless early operative intervention is undertaken. There are few published reports of successful medical management of GDU. Therefore, we reviewed 14 consecutive patients with GDU at our institution. Excluding the following cases: Two patients who had elective surgery, two patients who died from unrelated causes,

Richard Jaszewski; Steven A. Crane; Arturo A. Cid



Giant hydatid lung cysts  

Microsoft Academic Search

Objective: In this clinical retrospective study, we aimed to evaluate giant hydatid lung cyst cases as a different clinical entity that recorded in last 10 years in our clinic. Methods: Between February 1990 and May 2000, a total of 305 hydatid lung cyst cases from patients that had been operated were reviewed, and 67 (21.9%) cysts with more than 10

Nurettin Karaoglanoglu; Ibrahim Can Kurkcuoglu; Metin Gorguner; Atilla Eroglu; Atila Turkyilmaz


Giant hydatid lung cysts  

Microsoft Academic Search

Objective: In this clinical retrospective study, we aimed to evaluate giant hydatid lung cyst cases as a different clinical entity that recorded in last 10 years in our clinic. Methods: Between February 1990 and May 2000, a total of 305 hydatid lung cyst cases from patients that had been operated were reviewed, and 67 (21.9%) cysts with more than 10

Nurettin Karaoglanoglu; Ibrahim Can Kurkcuoglu; Metin Gorguner; Atilla Eroglu; Atila Turkyilmaz



Robust giant magnetoresistance sensors  

Microsoft Academic Search

The giant magnetoresistance (GMR) effect offers interesting new possibilities for sensor applications. A short overview is given of the GMR effect in relation to its application in (automotive and industrial) field sensors. In the past the thermal and magnetic stability could not fulfil the requirements for use in automotive and industrial environments. Recently, a new, robust GMR material system has

K.-M. H Lenssen; D. J Adelerhof; H. J Gassen; A. E. T Kuiper; G. H. J Somers; J. B. A. D van Zon



Posttraumatic giant renal pseudoaneurysm  

Microsoft Academic Search

Renal artery pseudoaneurysms secondary to blunt abdominal trauma are uncommon. We report a giant renal pseudoaneurysm, diagnosed\\u000a by computerized tomography 5 months after a blunt trauma, which was confirmed by catheter angiography and treated with selective\\u000a embolization.

Rodrigo Pastorín; Nuria Rodríguez; Ana María Polo; José Manuel Vicente; Marcos Luján



Spastic diplegia as a complication of interferon Alfa-2a treatment of hemangiomas of infancy  

Microsoft Academic Search

We report the development of spastic diplegia in infants during the course of interferon Alfa-2a (IFN) therapy for potentially life-endangering hemangiomas. Five infants who displayed diplegia were selected from a group of 26 infants treated with IFN. Diplegia persisted in three infants, and in the remaining two significant recovery occurred after IFN was discontinued. Magnetic resonance imaging showed no significant

Charles F. Barlow; Cedric J. Priebe; John B. Mulliken; Patrick D. Barnes; Dorothy Mac Donald; Judah Folkman; R. Alan B. Ezekowitz



Use of thalidomide to diminish growth velocity in a life-threatening congenital intracranial hemangioma  

PubMed Central

Infantile or capillary hemangioma is the most common vascular tumor of childhood. The tumors most frequently affect the head and neck area, but rare cases of intracranial lesions have been reported. Their natural history is marked by initial rapid growth velocity followed by a plateau and, in most cases, subsequent involution. Although the lesions are considered benign, 10% of affected children develop life-threatening complications (mortality rate 20–80% in this subgroup). When surgical intervention or other methods of local control are not possible, therapeutic options are limited. Corticosteroids have been the mainstay of therapy but therapeutic response is not predictable and the infectious risk is not negligible. Interferon ?-2a may also be effective but has significant toxicities. Vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) have been implicated in the pathogenesis of hemangiomas, and antiangiogenesis agents are being evaluated in the treatment of these tumors. Thalidomide may be an ideal therapy for life-threatening hemangiomas because it inhibits new blood vessel formation by antagonizing both the bFGF and VEGF pathways and has a more acceptable toxicity profile than other agents. The authors present the case of an infant born with a life-threatening, unresectable intracranial hemangioma in which treatment with thalidomide resulted in a good clinical outcome.

Frei-Jones, Melissa; McKinstry, Robert C.; Perry, Arie; Leonard, Jeffrey R.; Park, Tae Sung; Rubin, Joshua B.



Submandibular gland hemangioma: clinicopathologic features and a review of the literature.  


We conducted a retrospective study to determine the incidence and characteristics of submandibular gland hemangioma at our institution. We reviewed the records of all patients who had undergone submandibular gland excision from January 1998 through December 2006. We found a total of 230 such cases. Of these, submandibular gland hemangioma was found in 4 patients (1.7%)-3 women and 1 man, aged 20 to 47 years (mean 34.8). Their duration of symptoms had ranged from 26 to 78 months (mean: 49.3). These symptoms had included submandibular swelling, pain or discomfort, and features of sialadenitis. Computed tomographic angiography had revealed that the hemangiomas were supplied by the facial and lingual arteries. Two of the 4 patients had undergone preoperative vascular embolization, but it had failed to significantly reduce the amount of intraoperative blood loss. Final histopathologic examination had revealed that all 4 lesions were cavernous hemangiomas and that they had replaced the normal glandular structure. No recurrence was seen during a follow-up that ranged from 47 to 72 months (mean: 56.3). PMID:21086266

Kumar, Sudesh; Gupta, Ashok K; Bakshi, Jayamanti



Local steroid therapy of adnexal strawberry hemangioma in infants —long-term follow-up  

Microsoft Academic Search

Two patients with orbital or ocular adnexal neonatal hemangiomas were treated with intralesional injection of triamcinolone acetonide. Injection of steroids was started at 2 mg\\/kg twice a week. The doses of this drug were decreased gradually over a four week period. A dramatic reduction of the lesion was evident without a rebound phenomenon: however growth delay continued for only three

S. Abe



Sebaceous Gland Carcinoma of the Eyelid. Following radiation Therapy for Cavernous Hemangioma of the Face.  

National Technical Information Service (NTIS)

A 37-year-old woman had received multiple radiation treatments between the ages of 6 months and 15 years for an extensive cavernous hemangioma of the left side of the face. At age 27, a biopsy specimen disclosed squamous cell carcinoma arising in chronic ...

D. A. Schlernitzauer R. L. Font



Cavernous hemangiomas of the liver: Are there any indications for resection  

Microsoft Academic Search

A total of 163 patients with cavernous hemangiomas of the liver were managed at Paul Brousse Hospital between 1970 and 1992. The tumor was smaller than 4 cm in 54 patients and larger than 10 cm in 38 patients. The diagnostic sensitivities of the imaging procedures were as follows: ultrasonography 61%; angio-computed tomography scanning 77%; angiography 85%; magnetic resonance imaging

Olivier Farges; Salam Daradkeh; Henri Bismuth



The Application of the Potassium-Titanyl-Phosphate (KTP) Laser in the Management of Subglottic Hemangioma  

Microsoft Academic Search

Background: Subglottic hemangioma is the most common neoplasm of the infant airway. Most lesions involute spontaneously; however, some may grow to cause life-threatening respiratory tract distress. The standards of treatment have been tracheotomy, corti- costeroids, and laser vaporization. However, use of the carbon d ioxide l aser h as b een a ssociated w ith increased risk of damage to

David Madgy; Syed F. Ahsan; Darren Kest; Ira Stein


Rapid regrowth of a capillary hemangioma of the thoracic spinal cord.  


A 48-year-old man presented with a 2-week history of progressive gait disturbance. Neurological examinations showed mild weakness in his lower extremities and depreciation of deep sensation. Magnetic resonance (MR) imaging showed an intradural extramedullary enhanced lesion at the levels of the T10 and T11 vertebrae. Laminectomy of the T10 and T11 vertebrae was performed, and the vascular tumor on the spinal cord surface was completely resected. Histological analysis indicated that the lesion was a capillary hemangioma with an elevated proliferative index. Postoperatively, the patient showed rapid motor and sensory improvement. However, 6 months after the operation, MR imaging showed regrowth of the tumor although the clinical symptoms of the patient had not deteriorated. The patient has shown no tumor regrowth 9 years after the second operation. Capillary hemangiomas in the skin and soft tissues are often associated with high proliferative activity, and recurrence/regrowth is not infrequent. On the other hand, recurrence/regrowth of capillary hemangioma in the neuraxis after tumor resection has rarely been observed, even in cases of incomplete resection. The present case illustrates the treatment of recurrent capillary hemangioma of the spinal cord. PMID:23006883

Kaneko, Yoichi; Yamabe, Kazutoshi; Abe, Masamitsu



Corticosteroid Toxicity in Infants Treated for Endangering Hemangiomas: Experience and Guidelines for Monitoring  

Microsoft Academic Search

We share our experience in managing the adverse effects of corti- costeroids used in the treatment of infants with complicated he- mangiomas. During a 3-year period, 30 infants with complicated hemangiomas were treated with corticosteroids. Oral predniso- lone was used at an initial dose of 2 to 4 mg\\/kg per day and tapered for a total period ranging from 1

Francine Blei; Jennifer Chianese



Closure of the ventral hernia in the management of giant exomphalos: a word of caution  

Microsoft Academic Search

Giant exomphalos containing liver as its major component and with visceroabdominal disproportion presents difficult management options to a paediatric surgeon. At Starship Children’s Hospital, we deal with these with primary skin closure, if possible, followed by staged repair of the ventral hernia beginning in the 2nd year of life. During the closure of a ventral hernia, we encountered major hepatic

M. Kothari; Percy W. B. Pease



Hepatitis E  

Microsoft Academic Search

Hepatitis E has a world-wide distribution and causes substantial morbidity and mortality in some developing countries, particularly among pregnant women. Hepatitis E virus (HEV) has recently been cloned and sequenced, and new diagnostic tests have been developed. These tests have been used to begin to characterize the natural history and epidemiological features of HEV infection. Experimental vaccines have also been

Eric E. Mast; Michael A. Purdy; Krzysztof Krawczynski



Hepatitis Information for the Public  


... hepatitis. Hepatitis A Hepatitis A is an acute liver disease caused by the Hepatitis A virus (HAV), lasting ... More Information Hepatitis B Hepatitis B is a liver disease caused by the Hepatitis B virus (HBV). It ...


Minimal invasive method to treat hemangiomas of the oral cavity with a CO2 laser  

NASA Astrophysics Data System (ADS)

During the last six years we have developed a new CO2 laser technique for the treatment of symptomatic oral cavity hemangioma. Our new technique, named 'laser encircling technique', has especially succeeded during hemangioma buccal maxillary surgeries. The treatment consisted in the application of a line of points of CO2 laser circling the lesion. Depending on the position and size of the lesion, we used from 0.4 to 4.0 Joules/mm2 laser energy density per pulse, causing reduction in the size of the lesion throughout the sclerosis of nutritional vessels which led to reduction in size, volume and color of the hemangiomas with no significant bleeding or inflammatory reaction. In this work forty male and female patients, twelve to fifty years old, presenting medium to small size hemangiomas situated in different sites of the oral cavity such as the tongue, mouth vestibule, pharynx, tonsil area and lips were treated by the procedure described above. The number of laser applications was defined by the peculiarities of each case, varying form 3 to 6 sessions at 4 week intervals, always under local or topic anesthesia. The patients complained about minimal posit operative discomfort and had good cicatrix evolution. The good results achieved by this technique lead to the conclusion that CO2 laser for these types of hemangioma is an efficient and very secure method of treatment. An important aspect of our technique is the fact that using relatively low laser power we do not perform real surgery but a less aggressive alternative of treatment.

Nicola, Ester M.; Nicola, Jorge H.; Gusmao, Reinaldo J.; Coutinho, Adriana A.; Cassitas, Nilceu



Proton or photon irradiation for hemangiomas of the choroid? A retrospective comparison  

SciTech Connect

Purpose: The aim of this study was to compare, on a retrospective basis, the results of therapy in patients with uveal hemangioma treated with photon or proton irradiation at a single center. Methods and Materials: From 1993 to 2002 a total of 44 patients were treated. Until 1998 radiotherapy was given with 6 MV photons in standard fractionation of 2.0 Gy 5 times per week. In 1998 proton therapy became available and was used since then. A dose of 20 to 22.5 Cobalt Gray Equivalent (CGE) 68 MeV protons was given on 4 consecutive days. Progressive symptoms or deterioration of vision were the indications for therapy. Results: Of the 44 patients treated, 36 had circumscribed choroidal hemangiomas and 8 had diffuse choroidal hemangiomas (DCH) and Sturge-Weber syndrome. Of the patients, 19 were treated with photons with a total dose in the range of 16 to 30 Gy. A total of 25 patients were irradiated with protons. All patients with DCH but 1 were treated with photons. Stabilization of visual acuity was achieved in 93.2% of all patients. Tumor thickness decreased in 95.4% and retinal detachment resolved in 92.9%. Late effects, although generally mild or moderate, were frequently detected. In all, 40.9% showed radiation-induced optic neuropathy, maximum Grade I. Retinopathy was found in 29.5% of cases, but only 1 patient experienced more than Grade II severity. Retinopathy and radiation-induced optic neuropathy were reversible in some of the patients and in some resolved completely. No differences could be detected between patients with circumscribed choroidal hemangiomas treated with protons and photons. Treatment was less effective in DCH patients (75%). Conclusions: Radiotherapy is effective in treating choroidal hemangiomas with respect to visual acuity and tumor thickness but a benefit of proton therapy could not be detected. Side effects are moderate but careful monitoring for side effects should be part of the follow-up procedures.

Hoecht, Stefan [Clinic for Radiation Oncology and Radiotherapy, Charite Universitaetsmedizin Berlin, Campus Benjamin Franklin, Berlin (Germany)]. E-mail:; Wachtlin, Joachim [Department for Ophthalmology, Charite Universitaetsmedizin Berlin, Campus Benjamin Franklin, Berlin (Germany); Bechrakis, Nikolaos E. [Department for Ophthalmology, Charite Universitaetsmedizin Berlin, Campus Benjamin Franklin, Berlin (Germany); Schaefer, Christiane [Clinic for Radiation Oncology and Radiotherapy, Charite Universitaetsmedizin Berlin, Campus Benjamin Franklin, Berlin (Germany); Heufelder, Jens [Eye Treatment Facility at the Ion Beam Laboratory, Hahn-Meitner-Institut Berlin GmbH, Berlin (Germany); Cordini, Dino [Eye Treatment Facility at the Ion Beam Laboratory, Hahn-Meitner-Institut Berlin GmbH, Berlin (Germany); Kluge, Heinz [Eye Treatment Facility at the Ion Beam Laboratory, Hahn-Meitner-Institut Berlin GmbH, Berlin (Germany); Foerster, Michael [Department for Ophthalmology, Charite Universitaetsmedizin Berlin, Campus Benjamin Franklin, Berlin (Germany); Hinkelbein, Wolfgang [Clinic for Radiation Oncology and Radiotherapy, Charite Universitaetsmedizin Berlin, Campus Benjamin Franklin, Berlin (Germany)



PHACE association with intracranial, oropharyngeal hemangiomas, and an atypical patent ductus arteriosus arising from the tortuous left subclavian artery in a premature infant  

PubMed Central

PHACE association is a rare neurocutaneous condition in which facial hemangiomas associate with a spectrum of posterior fossa malformations, arterial cerebrovascular anomalies, cardiovascular anomalies, and eye anomalies. We reported a case of PHACE association in a premature infant showing facial, intracranial, and oropharyngeal hemangiomas with evidence of the Dandy-Walker variant and complicated cardiovascular anomalies, including a right-sided aortic arch and an atypical patent ductus arteriosus arising from a tortuous left subclavian artery. To our knowledge, intracranial hemangiomas are rare in PHACE association, and a concomitant oropharyngeal hemangioma has not been previously reported in the PHACE association literature. In infants presenting with large, plaque-like facial hemangiomas, it is important to conduct active cardiovascular and neurological evaluations. Special attention should be given to the laryngoscopic examination to search for additional hemangiomas in the airway.

Choi, Jang Hwan; Lee, Jung Ha; Kim, Hee Sup



[Forgotten hepatitis: the hepatitis E].  


Hepatitis E is caused by the Hepatitis E Virus (HEV), entericaly transmitted. In areas with poor sanitation, HEV is responsible for high endemicity and major outbreaks. In countries with high sanitary conditions, HEV is a zoonosis responsible for sporadic cases, and is encountered in travellers returning from endemic areas. The clinical manifestations are not distinguishable from that caused by other causes of acute viral hepatitis. Fulminant hepatitis are encountered in 1 to 4% of acute hepatitis E. Remarquably, mortality among pregnant women is very high. Diagnosis can be made by serological testing and eventually viral detection by PCR. HEV can cause chronic infection in immunocompromised patients. There is no specific therapy. There is no vaccine currently available. PMID:22662626

Bru, J-P



Effect of continuous positive airway pressure therapy on a large hemangioma complicated with obstructive sleep apnea syndrome: a case report  

Microsoft Academic Search

INTRODUCTION: Hemangiomas involving the upper airway can be an uncommon cause of obstructive sleep apnea syndrome. CASE PRESENTATION: A 26-year-old Caucasian man with a known history of a large hemangioma of his head and neck presented with sleep-disordered breathing to the sleep unit of our hospital. Severe obstructive sleep apnea syndrome was revealed on polysomnography. Nasal continuous positive airway pressure

Maria Antoniadou; Paschalis Steiropoulos; Evangelia Serasli; Venetia Tsara



Quantum giant magnon  

SciTech Connect

Understanding the finite-size corrections to the fundamental excitations of a theory is the first step towards completely solving for the spectrum in finite volume. We compute the leading exponential correction to the quantum energy of the fundamental excitation of the light-cone gauged string in AdS{sub 5}xS{sup 5}, which is the giant magnon solution. We present two independent ways to obtain this correction: the first approach makes use of the algebraic curve description of the giant magnon. The second relies on the purely field-theoretical Luescher formulas, which depend on the world-sheetS-matrix. We demonstrate the agreement to all orders in ({delta}/{radical}({lambda})){sup -1} of these approaches, which, in particular, presents a further test of the S-matrix. We comment on generalizations of this method of computation to other string configurations.

Gromov, Nikolay [Service de Physique Theorique, CNRS-URA 2306 C.E.A.-Saclay, F-91191 Gif-sur-Yvette (France); Laboratoire de Physique Theorique de l'Ecole Normale Superieure et l'Universite Paris-VI, Paris, 75231 (France); St. Petersburg INP, Gatchina, 188 300, St. Petersburg (Russian Federation); Schaefer-Nameki, Sakura [California Institute of Technology, 1200 E California Blvd., Pasadena, California 91125 (United States); Vieira, Pedro [Laboratoire de Physique Theorique de l'Ecole Normale Superieure et l'Universite Paris-VI, Paris, 75231 (France); Departamento de Fisica e Centro de Fisica do Porto Faculdade de Ciencias da Universidade do Porto Rua do Campo Alegre, 687, 4169-007 Porto (Portugal)



Phase II Study to Assess the Efficacy of Hypofractionated Stereotactic Radiotherapy in Patients With Large Cavernous Sinus Hemangiomas  

SciTech Connect

Purpose: Cavernous sinus hemangioma is a rare vascular tumor. The direct microsurgical approach usually results in massive hemorrhage. Although radiosurgery plays an important role in managing cavernous sinus hemangiomas as a treatment alternative to microsurgery, the potential for increased toxicity with single-session treatment of large tumors is a concern. The purpose of this study was to assess the efficacy of hypofractionated stereotactic radiotherapy in patients with large cavernous sinus hemangiomas. Methods: Fourteen patients with large (volume >20 cm{sup 3}) cavernous sinus hemangiomas were enrolled in a prospective Phase II study between December 2007 and December 2010. The hypofractionated stereotactic radiotherapy dose was 21 Gy delivered in 3 fractions. Results: After a mean follow-up of 15 months (range, 6-36 months), the magnetic resonance images showed a mean of 77% tumor volume reduction (range, 44-99%). Among the 6 patients with cranial nerve impairments before hypofractionated stereotactic radiotherapy, 1 achieved symptomatic complete resolution and 5 had improvement. No radiotherapy-related complications were observed during follow-up. Conclusion: Our current experience, though preliminary, substantiates the role of hypofractionated stereotactic radiotherapy for large cavernous sinus hemangiomas. Although a longer and more extensive follow-up is needed, hypofractionated stereotactic radiotherapy of 21 Gy delivered in 3 fractions is effective in reducing the tumor volume without causing any new deficits and can be considered as a treatment modality for large cavernous sinus hemangiomas.

Wang Xin; Liu Xiaoxia; Mei Guanghai; Dai Jiazhong; Pan Li [Departments of Neurosurgery and CyberKnife, Huashan Hospital, Fudan University, Shanghai (China); Wang Enmin, E-mail: [Departments of Neurosurgery and CyberKnife, Huashan Hospital, Fudan University, Shanghai (China)



Hot giant loop holography  

SciTech Connect

We argue that there is a phase transition in the expectation value of the Polyakov loop operator in the large N limit of the high temperature deconfined phase of N=4 Yang-Mills theory on a spatial S{sup 3}. It occurs for the large completely symmetric representation of the SU(N) symmetry group. We speculate that this transition is reflected in the D-branes which are the string theory duals of giant loops.

Grignani, Gianluca [Dipartimento di Fisica, Universita di Perugia, INFN Sezione di Perugia, Via A. Pascoli, 06123 Perugia (Italy); Karczmarek, Joanna L.; Semenoff, Gordon W. [Department of Physics and Astronomy, University of British Columbia, Vancouver, British Columbia V6T 1Z1 (Canada)



Printable giant magnetoresistive devices.  


The first printable magnetic sensor relying on the giant magnetoresistance effect (GMR) is demonstrated. It is prepared in the form of magneto-sensitive inks adherent to any kind of arbitrarily shaped surface. The fabricated sensor exhibits a room-temperature GMR of up to 8% showing great potential for contactless switching in hybrid electronic circuits (discrete semiconductor and printable elements) applied to the surface by regular painting. PMID:22761017

Karnaushenko, Daniil; Makarov, Denys; Yan, Chenglin; Streubel, Robert; Schmidt, Oliver G



Bound States of Giant Gravitons  

Microsoft Academic Search

We consider giant gravitons in the maximally supersymmetric type IIB plane- wave, in the presence of a constant NSNS B-field background. We show that in response to the background B-field the giant graviton would take the shape of a deformed three-sphere, the size and shape of which depend on the B-field, and that the giant becomes classically unstable once the

Sergey Prokushkin; M. M. Sheikh-Jabbari


Giant Left Atrium: A Review  

PubMed Central

Giant left atrium is a rare condition, with a reported incidence of 0.3%, and following mainly rheumatic mitral valve disease. Although rheumatic heart disease represents the main cause of giant left atrium, other etiologies have been reported. Giant left atrium has significant hemodynamic effects and requires specific management. In this review, we present two cases, discuss the different definitions, etiologies, clinical presentation and management modalities.

El Maghraby, Ahmed; Hajar, Rachel



Giant European dinosaur found in Spain  

NSDL National Science Digital Library

Fossils of a giant Sauropod, found in Spain, reveal that Europe was home to giant dinosaurs in the Late Jurassic period -- about 150 million years ago. Giant dinosaurs have previously been found mainly in the New World and Africa.

American Association for the Advancement of Science (AAAS;)



Hepatitis A  


... You can also get infected by eating contaminated food or drinking contaminated water. The virus can live on hands, in water and in soil. Hepatitis A is common in developing countries. Diagnosis & ...


Hepatitis B  

MedlinePLUS Videos and Cool Tools

... who need blood for medical conditions such as hemophilia • People who received a blood transfusion before 1992 • ... results of these tests and the patient’s health. Treatment For an acute hepatitis B infection, there is ...


Autoimmune hepatitis  

Microsoft Academic Search

Autoimmune hepatitis (AIH) is an inflammatory liver disease affecting mainly females and characterised histologically by interface\\u000a hepatitis, biochemically by elevated transaminase levels and serologically by the presence of autoantibodies and increased\\u000a levels of immunoglobulin G. AIH responds to immunosuppressive treatment, which should be instituted as soon as diagnosis is\\u000a made. Seropositivity for smooth muscle and\\/or anti-nuclear antibody defines type 1

Diego Vergani; Maria Serena Longhi; Dimitrios P. Bogdanos; Yun Ma; Giorgina Mieli-Vergani



[Autoimmune hepatitis].  


Autoimmune hepatitis is a systemic disease, difficult to diagnose due the high variability of the clinical presentation and some non specific histological features. The recent identification of additional autoantibodies used as serological markers, as well as simplified diagnostic criteria should help the primary care physician to advance with the diagnostic process. These progresses are crucial as undiagnosed and therefore untreated autoimmune hepatitis has a poor prognosis, whereas immunosuppressive therapy leads to remission in a majority of cases. PMID:23667973

Luong Ba, Kim; Juillerat, Pascal; Ducommun, Julien



BBB - Hepatitis A Virus  

Center for Food Safety and Applied Nutrition (CFSAN)

... The term hepatitis A (HA) or type A viral hepatitis has replaced all previous designations: infectious hepatitis, epidemic hepatitis, epidemic jaundice ... More results from


Giant Hedge-Hogs: Spikes on Giant Gravitons.  

National Technical Information Service (NTIS)

We consider giant gravitons on the maximally supersymmetric plane-wave background of type IIB string theory. Fixing the light-cone gauge, we work out the low energy effective light-cone Hamiltonian of the three-sphere giant graviton. At first order, this ...

D. Sadri M. M. Sheikh-Jabbari



Feature Hepatitis: Hepatitis Symptoms, Diagnosis, Treatment & Prevention  


... Navigation Bar Home Current Issue Past Issues Feature Hepatitis Hepatitis: Symptoms, Diagnosis, Treatment & Prevention Past Issues / Spring 2009 ... No appetite Fever Headaches Diagnosis To check for hepatitis viruses, your doctor will test your blood. You ...


Near-infrared laser treatment of complicated hemangiomas in children: ten-year clinical experience  

NASA Astrophysics Data System (ADS)

Results of application of low invasive laser technology (developed by authors: Proc. SPIE 5863, 107-115 (2005), Russian Federation patent No.2290228 of.27.12.06) to treatment of hemangiomas in children are presented and analyzed in this work. From 2001 the technology was applied to about 1500 children with more than 2000 hemangiomas. Majority of them were complicated ones: belong to cavernous or combined types or (and) were localized on problem places: on face near eyes, nose, and lips, on auricles, on perineum near anus and genitals, in respiratory and gastrointestinal tracts. Diode laser with wavelength 920, 970, and 1060 nm at distant and interstitial irradiation were applied. In case of need there applied endoscopes. Excellent and good results have been achieved in 94% cases; there was a significant improvement in the rest cases.

Abushkin, Ivan A.; Privalov, Valeriy A.; Lappa, Alexander V.



Primary intraosseous cavernous hemangioma of the clivus: case report and review of the literature.  


Primary intraosseous hemangiomas are benign, vascular malformations that account for approximately 1% of all primary bone neoplasms. These tumors are mostly found in vertebral bodies and are rarely seen in the calvarium, where they represent 0.2% of bony neoplasms. When found in the skull, they tend to present with vague symptoms and do not have the typical radiological findings suggestive of hemangiomas. Because of this, these tumors can be missed in many cases or may be misinterpreted as more ominous lesions like multiple myeloma or osteosarcoma. Involvement of the skull base is exceedingly rare, and presentation with cranial nerve unilateral polyneuropathies has not been reported. We report a patient case with review of recent pertinent literature. PMID:23943715

Gologorsky, Yakov; Shrivastava, Raj K; Panov, Fedor; Mascitelli, Justin; Signore, Anthony Del; Govindaraj, Satish; Smethurst, Mark; Bronster, David J



Primary Intraosseous Cavernous Hemangioma of the Clivus: Case Report and Review of the Literature  

PubMed Central

Primary intraosseous hemangiomas are benign, vascular malformations that account for approximately 1% of all primary bone neoplasms. These tumors are mostly found in vertebral bodies and are rarely seen in the calvarium, where they represent 0.2% of bony neoplasms. When found in the skull, they tend to present with vague symptoms and do not have the typical radiological findings suggestive of hemangiomas. Because of this, these tumors can be missed in many cases or may be misinterpreted as more ominous lesions like multiple myeloma or osteosarcoma. Involvement of the skull base is exceedingly rare, and presentation with cranial nerve unilateral polyneuropathies has not been reported. We report a patient case with review of recent pertinent literature.

Gologorsky, Yakov; Shrivastava, Raj K.; Panov, Fedor; Mascitelli, Justin; Signore, Anthony Del; Govindaraj, Satish; Smethurst, Mark; Bronster, David J.



Laser ablation of a large tongue hemangioma with remifentanil analgosedation in the ORL endoscopy suite.  


We present a unique, practical, and safe approach to the clinical management of a young male with a large tongue hemangioma who presented for serial surgical treatment of the lesion. Laser ablation was undertaken in the operating room under topical anesthesia with remifentanil analgosedation without the use of supplemental oxygen. Significant involution of the hemangioma was achieved without complication while the patient was awake, cooperative, and able to protect his airway. The application of remifentanil infusion for analgosedation during airway surgery is described. The utility of pharmacokinetic modeling in these applications is discussed along with the use of non-invasive respiratory inductance plethysmography to monitor ventilation during opioid sedation. The concept of analgosedation for airway surgery is introduced and relative risk versus benefit considerations of the approach in comparison to general anesthesia are discussed. This approach can be conceived of as an ORL endoscopy suite model for limited airway procedures. PMID:21613798

Atkins, Joshua H; Mandel, Jeff E; Mirza, Natasha



A Giant Hemorrhagic Adrenal Pseudocyst  

Microsoft Academic Search

Objective: To report a rare case of a giant hemorrhagic adrenal pseudocyst and highlight the importance of this entity to clinicians. Case Presentation: A 57-year-old woman presented with a 1-year history of abdominal pain and distension. Ultrasonography and multislice computed tomography revealed a giant cystic (partially solid) mass over the left suprarenal region measuring 20 × 17 × 15 cm.

Goran Stimac; Josip Katusic; Mario Sucic; Mario Ledinsky; Bozo Kruslin; Davor Trnski



Giant Coulomb blockade magnetoresistance  

SciTech Connect

We show that the Coulomb blockade voltage can be made to depend strongly on the electron spin in a thin magnetic granular layer inserted in the middle of an insulating layer of a tunnel junction. This strong spin dependence is predicted from the spin-dependent inter-granular conductance through any of the following effects within the granular layer, giant magnetoresistance (GMR), tunneling magnetoresistance (TMR), colossal magnetoresistance (CMR), or GMR through a polymer spacer. The resulting Coulomb blockade magnetoresistance (CBMR) ratio can exceed the magnetoresistance ratio of the granular layer itself by orders of magnitude. Unlike other magenetoresistance effects, the CBMR effect does not require magnetic electrodes.

Zhang, Xiaoguang [ORNL; Wen, Z. C. [Institute of Physics, Chinese Academy of Science; Wei, H. X. [Institute of Physics, Chinese Academy of Science; Han, Prof. X. F. [Institute of Physics, Chinese Academy of Science



[Use of CO2 laser in the treatment of skin hemangiomas in children].  


The use of the CO2-laser in the treatment of hemangiomas in children is very promising because it opens new possibilities of "conservative surgery", reducing the terms of treatment, improving the cosmetic results, besides, there are no difficult anatomical localizations for the method. The choice of optimal radiation parameters allows the unique properties of laser energy to be exhibited effectively in extradermal pediatric surgery. PMID:2124307

Sleptsov, V P; Diadiura, A M



Effect of electro-acupuncture in treating patients with lingual hemangioma  

Microsoft Academic Search

Objective: To explore the clinical effect of electro-acupuncture (EA) in treating patients with lingual hemangioma (LHG).Methods: EA therapy was applied on 36 patients by directly inserting the platinum needles into LHG through a trocar with plastic\\u000a insulating cannula to protect the normal tissues and connecting the needles with the electro-chemical therapeutic apparatus\\u000a of model ZAY-B. Then electricity was given until

Li Jing-hong; Xin Yu-ling; Zhang Wei; Liu Jiang-tao; Quan Kuan-hong



Observation on the effect of electro-acupuncture in treating maxillofacial hemangioma  

Microsoft Academic Search

Objective: To investigate the clinical effect of electro-acupuncture (EA) in treating maxillofacial hemangioma (MFH).Methods: Platinum needles (electrode) were inserted into the MFH in 405 patients, the locations of which were found with the guidance\\u000a of B-ultrasonography or CT, and the number of needles was decided by the size of the MFH, the distance between needles was\\u000a about 1. 5cm, and

Zhang Wei; Xin Yu-ling; Zhao Hong-chang



Turner's syndrome in association with hemangioma of the parotid gland: report of case.  


We report a case of Turner's syndrome with hemangioma of the parotid gland. The symptom complex of this syndrome are infantilism, pterygium colli and unusual carrying angle of the elbow. Orodental alterations and multisystem afflictions have been reported in these patients. Diagnosis is based on a combination of the clinical features, buccal smear finding of the absence of barr body and confirmed by karyotyping which can detect mosaic cell lines of the X chromosome. PMID:7775687

Mysore, J; Roth, L M; Kafrawy, A H


Stereotactic Fractionated Radiotherapy for Recurrent Capillary Hemangioma of the Cavernous Sinus  

Microsoft Academic Search

Background and Purpose:  Capillary hemangioma of the cavernous sinus is a rare benign skull base tumor that can successfully be treated with radiotherapy. Due to its location, both the tumor itself and the treatment might cause significant functional deficits. Therefore, the different treatment options should be discussed with the patients.Case Report:  A case of successful stereotactic fractionated radiotherapy (SFRT) performed after multiple

Anca L. Grosu; Carsten Nieder



Hemangioma of the thyroid gland in an adolescent with chronic lymphocytic thyroiditis and adenomatous hyperplasia  

Microsoft Academic Search

We report a case of benign hemangioma of the thyroid gland which involved one lobe of the thyroid gland in an adolescent female\\u000a with classic chronic lymphocytic thyroiditis and adenomatous hyperplasia. The lesion produced a clinical picture suspicious\\u000a for malignancy owing to the presence of a very large cold nodule on scan, lack of response to TSH suppression, and the

Martha R. Clarke; Sushma Boppana



Symptomatic vertebral hemangioma in pregnancy treated antepartum. A case report with review of literature  

Microsoft Academic Search

Pregnancy related compressive myelopathy secondary to vertebral hemangioma is a rare occurrence and its treatment antepartum\\u000a is rare. We report a 22-year-old lady in her 26th-week of pregnancy who was treated in two stages––antepartum with a laminectomy\\u000a and posterior stabilization. This resulted in complete recovery of the neurological deficits. She delivered a normal baby\\u000a after 3 months, following which a corpectomy

Kamath Vijay; Ajoy P. Shetty; S. Rajasekaran



Right atrial giant myxoma occupying the right ventricular cavity.  


We report a case of a giant right atrial myxoma mimicking the right ventricular tumor. The 75-year-old patient underwent cardiac surgery, and the tumor was excised along with the stalk. Tricuspid valve annuloplasty was performed before closure of the right atriotomy. The tumor may have caused intraventricular stenosis, hepatic dysfunction, and progressive fatigue as a result of low cardiac output. This case is of special interest because the myxoma was very large compared with those ever reported, and a right atrial myxoma occupying the right ventricular cavity is rare. PMID:22579896

Sato, Teruki; Watanabe, Hiroyuki; Okawa, Megumi; Iino, Takako; Iino, Kenji; Ishibashi, Kazuyuki; Yamamoto, Hiroshi; Yamamoto, Fumio; Ito, Hiroshi



Central Retinal and Posterior Ciliary Artery Occlusion After Intralesional Injection of Sclerosant to Glabellar Subcutaneous Hemangioma  

SciTech Connect

The aim of this study is to describe vision loss caused by central retinal artery and posterior ciliary artery occlusion as a consequence of sclerotherapy with a polidocanol injection to a glabellar hemangioma. An 18-year-old man underwent direct injection with a 23-gauge needle of 1 mL of a polidocanol-carbon dioxide emulsion into the glabellar subcutaneous hemangioma under ultrasound visualization of the needle tip by radiologists. He developed lid swelling the next day, and 3 days later at referral, the visual acuity in the left eye was no light perception. Funduscopy revealed central retinal artery occlusion and fluorescein angiography disclosed no perfusion at all in the left fundus, indicating concurrent posterior ciliary artery occlusion. The patient also showed mydriasis, blepharoptosis, and total external ophthalmoplegia on the left side. Magnetic resonance imaging demonstrated the swollen medial rectus muscle. In a month, blepharoptosis and ophthalmoplegia resolved but the visual acuity remained no light perception. Sclerosing therapy for facial hemangioma may develop a severe complication such as permanent visual loss.

Matsuo, Toshihiko, E-mail: [Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Department of Ophthalmology (Japan); Fujiwara, Hiroyasu; Gobara, Hideo; Mimura, Hidefumi; Kanazawa, Susumu [Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Department of Radiology (Japan)



[Involvement of splenic hemangioma and rectal varices in a patient with klippel: trenaunay syndrome].  


Klippel - Trenaunay syndrome (KTS) is characterized by a cutaneous vascular nevus of the involved extremity, bone and soft tissue hypertrophy of the extremity and venous malformations. We present a case of KTS with splenic hemangiomas and rectal varices. A 29-year-old woman was referred for intermittent hematochezia for several years. She had history with a number of operations for cutaneous and soft tissue hamangiomas since the age of one year old and for increased circumference of her left thigh during the last few months. Abdominal CT revealed multiple hemangiomas in the spleen, fusiform aneurysmal dilatation of the deep veins and soft tissue hemangiomas. There was no evidence of hepatosplenomegaly or liver cirrhosis. Colonoscopy revealed hemangiomatous involvement in the rectum. There were rectal varices without evidence of active bleeding. Upon venography of the left leg, we also found infiltrative dilated superficial veins in the subcutaneous tissue and aneurysmal dilatation of the deep veins. The patient was finally diagnosed with KTS, and treated with oral iron supplementation only, which has been tolerable to date. Intervention or surgery is not required. When gastrointestinal varices or hemangiomatous mucosal changes are detected in a young patient without definite underlying cause, KTS should be considered. PMID:21960105

Choi, Youn Jung; Jee, Sam Ryong; Park, Kwan Sik; Ryu, Choong Heon; Seo, Hyo Rim; Ha, Seoung In; Lee, Sang Heon; Ok, Kyung Sun



Allometry indicates giant eyes of giant squid are not exceptional  

PubMed Central

Background The eyes of giant and colossal squid are among the largest eyes in the history of life. It was recently proposed that sperm whale predation is the main driver of eye size evolution in giant squid, on the basis of an optical model that suggested optimal performance in detecting large luminous visual targets such as whales in the deep sea. However, it is poorly understood how the eye size of giant and colossal squid compares to that of other aquatic organisms when scaling effects are considered. Results We performed a large-scale comparative study that included 87 squid species and 237 species of acanthomorph fish. While squid have larger eyes than most acanthomorphs, a comparison of relative eye size among squid suggests that giant and colossal squid do not have unusually large eyes. After revising constants used in a previous model we found that large eyes perform equally well in detecting point targets and large luminous targets in the deep sea. Conclusions The eyes of giant and colossal squid do not appear exceptionally large when allometric effects are considered. It is probable that the giant eyes of giant squid result from a phylogenetically conserved developmental pattern manifested in very large animals. Whatever the cause of large eyes, they appear to have several advantages for vision in the reduced light of the deep mesopelagic zone.



Giant papillary conjunctivitis.  

PubMed Central

Giant papillary conjunctivitis is a syndrome found frequently as a complication of contact lenses. Many variables can affect the onset and severity of the presenting signs and symptoms. Rigid gas permeable contact lenses appear to result in less severe signs and symptoms, with a longer time before the development of giant papillary conjunctivitis. Nonionic, low-water-content soft contact lenses tend to produce less severe signs and symptoms than ionic, low-water-content soft contact lenses. Enzymatic treatment appears to lessen the severity of signs and symptoms. The association of an allergy appears to play a role in the onset of the severity of the signs and symptoms but does not appear to affect the final ability of the individual to wear contact lenses. Using multiple treatment options, such as changing the polymer to a glyceryl methyl methacrylate or a rigid lens, or utilizing a soft lens on a frequent-replacement basis, can result in a success rate of over 90%. In individuals who still have a return of symptoms, the use of topical mast cell stabilizers or a nonsteroidal anti-inflammatory drug as an adjunctive therapy offers the added possibility of keeping these patients in contact lenses. Images FIGURE 1 FIGURE 2 FIGURE 3 FIGURE 4 FIGURE 5 FIGURE 6 FIGURE 7 FIGURE 11 A FIGURE 11 B FIGURE 11 C FIGURE 11 D

Donshik, P C



Rheology of giant micelles  

NASA Astrophysics Data System (ADS)

Giant micelles are elongated, polymer-like objects created by the self-assembly of amphiphilic molecules (such as detergents) in solution. Giant micelles are typically flexible, and can become highly entangled even at modest concentrations. The resulting viscoelastic solutions show fascinating flow behaviour (rheology) which we address theoretically in this article at two levels. First, we summarize advances in understanding linear viscoelastic spectra and steady-state nonlinear flows, based on microscopic constitutive models that combine the physics of polymer entanglement with the reversible kinetics of self-assembly. Such models were first introduced two decades ago, and since then have been shown to explain robustly several distinctive features of the rheology in the strongly entangled regime, including extreme shear thinning. We then turn to more complex rheological phenomena, particularly involving spatial heterogeneity, spontaneous oscillation, instability and chaos. Recent understanding of these complex flows is based largely on grossly simplified models which capture in outline just a few pertinent microscopic features, such as coupling between stresses and other order parameters such as concentration. The role of ‘structural memory’ (the dependence of structural parameters such as the micellar length distribution on the flow history) in explaining these highly nonlinear phenomena is addressed. Structural memory also plays an intriguing role in the little-understood shear thickening regime, which occurs in a concentration regime close to but below the onset of strong entanglement, and which is marked by a shear-induced transformation from an inviscid to a gelatinous state.

Cates, M. E.; Fielding, S. M.



Rapidly Evolving Giant Dermatofibroma  

PubMed Central

Dermatofibroma, also known as “fibrous histiocytoma”, is a benign dermal or subcutaneous poorly circumscribed proliferation of spindle-shaped fibroblasts and macrophages in the dermis. Although it is commonly present as a brownish nodule the legs of females, it may also arise on the upper extremities, trunk, and rarely on the head. The exact pathogenesis is unclear. However, it is widely believed that the originating insult to the dermis is a folliculitis, an arthropod bite, or an unspecified initial inflammatory condition. Giant dermatofibromas of greater than 5?cm in diameter are rare, with only 22 cases reported in the literature. We present a case of a rapidly evolving pedunculated mass in the groin of a male patient. Histological examination confirmed this to be a giant dermatofibroma. Though this specimen cannot is not confirmed as such, the cellular subtype is sometimes present as a larger lesion with anecdotal reports of local recurrence and distant metastases. The clinical and radiological features which were somewhat suspicious of malignancy are considered in the context of the definitive pathological diagnosis of a benign lesion.

Lang, K. J.; Lidder, S.; Hofer, M.; Graham, C.; Taylor, A.



Red giants rotational splittings  

NASA Astrophysics Data System (ADS)

The space missions CoRoT and Kepler provide high quality data that allow to test the transport of angular momentum in stars by the seismic determination of the internal rotation profile. Our aim is to test the validity of the seismic diagnostics for red giant rotation that are based on a perturbative method and to investigate the oscillation spectra when the validity does not hold. We use a non-perturbative approach implemented in the ACOR code [1] that accounts for the effect of rotation on pulsations, and solves the pulsations eigenproblem directly for dipolar oscillation modes. We find that the limit of the perturbation to first order can be expressed in terms of the core rotation and the period separation between consecutive dipolar modes. Above this limit, each family of modes with different azimuthal symmetry m, has to be considered separately. For rapidly rotating red giants, new seismic diagnostics can be found for rotation by exploiting the differences between the period spacings associated with each m-family of modes.

Ouazzani, R. M.; Goupil, M. J.; Dupret, M. A.; Marques, J. P.



Novel sequences of subgroup J avian leukosis viruses associated with hemangioma in Chinese layer hens  

PubMed Central

Background Avian leukosis virus subgroup J (ALV-J) preferentially induces myeloid leukosis (ML) in meat-type birds. Since 2008, many clinical cases of hemangioma rather than ML have frequently been reported in association with ALV-J infection in Chinese layer flocks. Results Three ALV-J strains associated with hemangioma were isolated and their proviral genomic sequences were determined. The three isolates, JL093-1, SD09DP03 and HLJ09MDJ-1, were 7,670, 7,670, and 7,633 nt in length. Their gag and pol genes were well conserved, with identities of 94.5-98.6% and 97.1-99.5%, respectively, with other ALV-J strains at the amino acid level (aa), while the env genes of the three isolates shared a higher aa identity with the env genes of other hemangioma strains than with those of ML strains. Interestingly, two novel 19-bp insertions in the U3 region in the LTR and 5' UTR, most likely derived from other retroviruses, were found in all the three isolates, thereby separately introducing one E2BP binding site in the U3 region in the LTR and RNA polymerase II transcription factor IIB and core promoter motif ten elements in the 5' UTR. Meanwhile, two binding sites in the U3 LTRs of the three isolates for NFAP-1 and AIB REP1 were lost, and a 1-base deletion in the E element of the 3' UTR of JL093-1 and SD09DP03 introduced a binding site for c-Ets-1. In addition to the changes listed above, the rTM of the 3' UTR was deleted in each of the three isolates. Conclusion Our study is the first to discovery the coexistence of two novel insertions in the U3 region in the LTR and the 5' UTR of ALV-J associated with hemangioma symptoms, and the transcriptional regulatory elements introduced should be taken into consideration in the occurrence of hemangioma.



Giant resonances: Progress, new directions, new challenges  

SciTech Connect

A review of some recent developments in the field of giant multipole resonances is presented. Particular emphasis is placed on directions that the authors feel will be followed in this field during the next several years. In particular, the use of high-energy heavy ions to excite the giant resonances is shown to provide exciting new capabilities for giant resonance studies. Among subjects covered are: Coulomb excitation of giant resonances, photon decay of giant resonances, the recent controversy over the identity of the giant monopole resonance, the most recent value for incompressibility of nuclear matter from analysis of giant monopole data, the isospin character of the 63 A/sup /minus/1/3/ GQR, agreement between (e,e/prime/) and (hadron, hadron/prime/) excitation of the giant quadrupole resonance, prospects for multiphonon giant resonance observation, and isolation of the isovector giant quadrupole resonance. 55 refs., 23 figs., 4 tabs.

Bertrand, J.R.; Beene, J.R.



The footpoints of giant arches  

NASA Astrophysics Data System (ADS)

H-alpha photographs are presented, which show chromospheric footpoints of the giant post-flare arches discovered by the Hard X-ray Imaging Spectrometer on the SMM satellite. The photographs display chromospheric signatures associated with five sequential giant arch events observed during November 6-10, 1980. The sets of footpoints at both ends of the arches have very slow brightness variations correlated in time with the brightness variations of the X-ray arches. The identifications of the two sets of footpoints is confirmed by current-free modeling of the coronal magnetic field (Kopp and Poletto, 1989). Possible explanations for the giant arch phenomenon are discussed.

Martin, Sara F.; Svestka, Zdenek F.; Bhatnagar, Arvind



Hepatitis C  

MedlinePLUS Videos and Cool Tools

... before they have a chance to poison the body. The liver also makes bile; a yellowish liquid that helps absorb the food we eat. Bile ... they could damage your liver. • Follow directions from your doctors about ... them about any side effects you may experience. • Women with Hepatitis C should ...


Autoimmune hepatitis  

Microsoft Academic Search

Autoimmune hepatitis (AIH) is a distinct form of acute and chronic inflammatory liver disease in which immune reactions against host antigens are found to be the major pathological mechanism. If left untreated it carries an unfavourable prognosis, and the diagnosis should be made as soon as possible. The diagnostic approach has been greatly facilitated by the establishment of a panel

Karl-Hermann Meyer zum Büschenfelde; Hans-Peter Dienes



Hepatic failure  

Microsoft Academic Search

Acute liver failure is a rare multisystem disease that is characterised by the development of encephalopathy and coagulopathy within 26 weeks of the onset of symptoms in a patient with previously normal liver function. The commonest causes are viral hepatitis and acetaminophen overdose. The prognosis depends on the aetiology and the grade of encephalopathy at presentation. Because of the rapid

Kevin EJ Gunning



Giant Hedge-Hogs: Spikes on Giant Gravitons  

SciTech Connect

We consider giant gravitons on the maximally supersymmetric plane-wave background of type IIB string theory. Fixing the light-cone gauge, we work out the low energy effective light-cone Hamiltonian of the three-sphere giant graviton. At first order, this is a U(1) gauge theory on R x S{sup 3}. We place sources in this effective gauge theory. Although non-vanishing net electric charge configurations are disallowed by Gauss' law, electric dipoles can be formed. From the string theory point of view these dipoles can be understood as open strings piercing the three-sphere, generalizing the usual BIons to the giant gravitons, BIGGons. Our results can be used to give a two dimensional (worldsheet) description of giant gravitons, similar to Polchinski's description for the usual D-branes, in agreement with the discussions of hep-th/0204196.

Sadri, D



Giant hedge-hogs: spikes on giant gravitons  

NASA Astrophysics Data System (ADS)

We consider giant gravitons on the maximally supersymmetric plane-wave background of type IIB string theory. Fixing the light-cone gauge, we deduce the low energy effective light-cone Hamiltonian of the three-sphere giant graviton. At first order, this is a U(1) gauge theory on R×S3. We place sources in this effective gauge theory. Although non-vanishing net electric charge configurations are disallowed by Gauss' law, electric dipoles can be formed. From the string theory point of view these dipoles can be understood as open strings piercing the three-sphere, generalizing the usual BIons to the giant gravitons (BIGGons). Our results can be used to give a two-dimensional (worldsheet) description of giant gravitons, similar to Polchinski's description for the usual D-branes, in agreement with the discussions of hep-th/0204196.

Sadri, Darius; Sheikh-Jabbari, M. M.



Giant biliary cystadenoma complicated with polycystic liver: A case report  

PubMed Central

Biliary cystadenoma (BCA) is a rare hepatic neoplasm. Although considered a benign cystic tumor of the liver, BCA has a high risk of recurrence with incomplete excision and a potential risk for malignant degeneration. Correct diagnosis and complete tumor excision with negative margins are the mainstay of treatment. Unfortunately, due to the lack of presenting symptoms, and normal laboratory results in most patients, BCA is hard to distinguish from other cystic lesions of the liver such as biliary cystadenocarcinoma, hepatic cyst, hydatid cyst, Caroli disease, undifferentiated sarcoma, intraductal papillary mucinous tumor, and hepatocellular carcinoma. Ultrasound (US), computed tomography (CT) and magnetic resonance imaging (MRI) may be necessary. They demonstrate intrahepatic cystic lesions with features such as mural nodules, varying wall thickness, papillary projections, and internal septations. Nevertheless, surgery is still the only means of accurate diagnosis. Definitive diagnosis requires histological examination following formal resection. We describe a 57-year-old woman initially diagnosed with polycystic liver who was subsequently diagnosed with giant intrahepatic BCA in the left hepatic lobe. This indicates that both US physicians and hepatobiliary specialists should attach importance to hepatic cysts, and CT or MRI should be performed for further examination when a diagnosis of BCA is suspected.

Yang, Zhen-Zhen; Li, Yong; Liu, Jun; Li, Kuang-Fan; Yan, Ye-Hong; Xiao, Wei-Dong



Giant serpentine aneurysms.  


Segal and McLaurin first described giant serpentine aneurysms, based on their distinct angiographic features, in 1977. These lesions are >or= 25 mm, partially thrombosed aneurysms with a patent, serpiginous vascular channel that courses through the aneurysm. There is a separate inflow and outflow of the aneurysm, of which the outflow channel supplies brain parenchyma in the territory of the parent vessel. Given the large size, unique neck, and dependent distal vessels, these aneurysms pose a technical challenge in treatment. Initial management has included surgical obliteration, but as endovascular techniques have evolved, treatment options too have expanded. In this review the authors attempt to summarize the existing body of literature on this rare entity and describe some of their institutional management strategies. PMID:19409006

Christiano, Lana D; Gupta, Gaurav; Prestigiacomo, Charles J; Gandhi, Chirag D



Giant mediastinal mass: thymolipoma.  


A 26-year-old man presented with shortness of breath on exertion that was gradually getting worse. His history revealed a mass in the left hemithorax that had been growing on follow-ups. Physical examination only showed that the respiratory sounds were fainter on the left. Thoracic computerized tomography was performed to elucidate the left hemithorax lesion seen on chest x-ray and a giant mass of lipid density extending from the anterior mediastinum to the diaphragm and filling almost the entire left hemithorax was observed. Total excision of the 25 × 21 × 8 cm mass weighing 1580 g was performed with a left thoracotomy. The histopathology investigation of the mass was reported as thymolipoma. The case was presented because it is a rare mediastinal mass. PMID:21606717

Alar, Timuçin; Ozçelik, Cemal; Kilnç, Nihal



A giant Ordovician anomalocaridid.  


Anomalocaridids, giant lightly sclerotized invertebrate predators, occur in a number of exceptionally preserved early and middle Cambrian (542-501?million years ago) biotas and have come to symbolize the unfamiliar morphologies displayed by stem organisms in faunas of the Burgess Shale type. They are characterized by a pair of anterior, segmented appendages, a circlet of plates around the mouth, and an elongate segmented trunk lacking true tergites with a pair of flexible lateral lobes per segment. Disarticulated body parts, such as the anterior appendages and oral circlet, had been assigned to a range of taxonomic groups--but the discovery of complete specimens from the middle Cambrian Burgess Shale showed that these disparate elements all belong to a single kind of animal. Phylogenetic analyses support a position of anomalocaridids in the arthropod stem, as a sister group to the euarthropods. The anomalocaridids were the largest animals in Cambrian communities. The youngest unequivocal examples occur in the middle Cambrian Marjum Formation of Utah but an arthropod retaining some anomalocaridid characteristics is present in the Devonian of Germany. Here we report the post-Cambrian occurrence of anomalocaridids, from the Early Ordovician (488-472?million years ago) Fezouata Biota in southeastern Morocco, including specimens larger than any in Cambrian biotas. These giant animals were an important element of some marine communities for about 30?million years longer than previously realized. The Moroccan specimens confirm the presence of a dorsal array of flexible blades attached to a transverse rachis on the trunk segments; these blades probably functioned as gills. PMID:21614078

Van Roy, Peter; Briggs, Derek E G



Landscape of the lost giants  

NASA Astrophysics Data System (ADS)

The Pleistocene megafauna extinction erased a group of remarkable animals. Whether humans had a prominent role in the extinction remains controversial, but it is emerging that the disappearance of the giants has markedly affected the environment.



Giant magnetoresistance in narrow stripes  

Microsoft Academic Search

A simple model for giant magnetoresistance in thin-film magnetic sandwiches was developed. Giant magnetoresistance (GMR) and anisotropic magnetoresistance (AMR) were measured using 1.5-?m to 10-?m-wide×70-?m-long test structures etched from magnetic sandwiches with two magnetic films and a thin nonmagnetic conducting interlayer. Magnetic fields were applied to the sandwiches by passing current through the stripes and by applying external fields. The

J. M. Daughton; P. A. Bade; M. L. Jenson; M. M. M. Rahmati



Hepatitis A FAQs  


... or not Have clotting-factor disorders, such as hemophilia Live with someone who has Hepatitis A Have ... diseases, such as Hepatitis B or C. Diagnosis / Treatment How will I know if I have Hepatitis ...


Drug-induced hepatitis  


Toxic hepatitis ... to get liver damage. Some drugs can cause hepatitis with small doses, even if the liver breakdown ... liver. Many different drugs can cause drug-induced hepatitis. Painkillers and fever reducers that contain acetaminophen are ...


Diabetes and Hepatitis B Vaccination  


Diabetes and Hepatitis B Vaccination Information for Diabetes Educators What is hepatitis B? Hepatitis B is a contagious liver disease that ... as liver failure or liver cancer. How is hepatitis B spread? The hepatitis B virus is usually ...


Autoimmune hepatitis  

Microsoft Academic Search

Autoimmune hepatitis (AIH) is a rare disease, characterized by female predominance, hypergammaglobulinemia, autoantibodies, association with HLA DR3 and HLA DR4 and a good response to immunosuppression. Different subtypes of AIH may be distinguished, based on differences in the autoantibody patterns. AIH type 1 is characterized by anti-nuclear (ANA) and\\/or anti-smooth muscular (SMA) autoantibodies. AIH type 2 is characterized by liver\\/kidney

Petra Obermayer-Straub; Christian P. Strassburg; Michael P. Manns



The Giant Magnetocaloric Effect  

NASA Astrophysics Data System (ADS)

Since the discovery of the magnetocaloric effect in pure iron by E.Warburg in 1881, it has been measured experimentally on many magnetic metals and compounds. The majority of the materials studied order magnetically undergoing a second order phase transformation. The magnetocaloric effect, typically peaking near the Curie or the Néel temperature, generally ranges from 0.5 to 2 K (in terms of adiabatic temperature change) or at 1 to 4 J/kg K (in terms of isothermal magnetic entropy change) per 1 T magnetic field change. The giant magnetocaloric effect recently discovered in Gd_5(Si_xGe_1-x)4 alloys, where x <= 0.5, is associated with a first order magnetic phase transition and it reaches values of 3 to 4 K and 6 to 10 J/kg K per 1 T field change, respectively. The refrigerant capacity, which is the measure of how much heat can be transferred from a cold to a hot reservoir in one ideal thermodynamic cycle, is larger than that of the best second order phase transition materials by 25 to 100%. When the Gd_5(Si_xGe_1-x)4 alloys are compared with other known materials, which show first order magnetic phase transition, such as Dy, Ho, Er, HoCo_2, NdMn_2Si_2, Fe_0.49Rh_0.51, and (Hf_0.83Ta_0.17)Fe_2+x, only Fe_0.49Rh_0.51 has comparable magnetocaloric properties. However, the first order magnetic phase transition in Fe_0.49Rh_0.51 is irreversible, and the magnetocaloric effect disappears after one magnetizing/demagnetizing cycle. A study of the crystal structure, thermodynamics, and magnetism of the Gd_5(Si_xGe_1-x)4 alloys, where 0 <= x <= 1 allowed us to obtain a qualitative understanding of the basic relations between the composition, the crystal structure, and the change in thermodynamics and magnetocaloric properties, which occur in the Gd_5(Si_xGe_1-x)4 system, and which brings about the giant magnetocaloric effect when x <= 0.5.

Pecharsky, Vitalij K.



Anastomosing hemangioma of the liver and gastrointestinal tract: an unusual variant histologically mimicking angiosarcoma.  


Anastomosing hemangioma, a benign vascular neoplasm histologically simulating angiosarcoma, is newly recognized and has been described primarily in the genitourinary tract. We have encountered this lesion in the liver and gastrointestinal tract, where it can be diagnostically challenging, especially in core biopsy. Herein, we described 6 cases of anastomosing hemangioma of the liver and gastrointestinal tract. They occurred in 4 women and 2 men, ranging in age from 48 to 71 years. The tumors ranged from 0.2 to 6 cm (median, 3.1 cm) and were grossly well demarcated with a gray-brown spongy appearance. Microscopically, they had a loosely lobulated architecture. At higher magnification, lesions consisted of anastomosing sinusoidal capillary-sized vessels with scattered hobnail endothelial cells. Mild cytologic atypia occurred in all cases. Mitoses were absent. Vascular thrombi were seen in 4 cases (66.7%) without necrosis. One tumor (16.7%) featured prominent extramedullary hematopoiesis and 1 (16.7%) hyaline globules. Immunohistochemistry results were available for 3 cases, and the lesions stained with CD34 and/or CD31. Five cases had clinical follow-up information; there were no recurrences or metastases (range, 8 to 96 mo; mean, 41 mo), and 1 patient received no follow-up after a benign diagnosis on her colon polyp. In summary, anastomosing hemangioma of the liver and gastrointestinal tract is a rare distinctive vascular neoplasm displaying overlapping features with well-differentiated angiosarcoma. Despite small numbers and limited follow-up information in our series, evidence to date supports that the lesion is benign. Awareness of this entity is essential to avoid overdiagnosis and unnecessary aggressive treatment. PMID:23887160

Lin, Jingmei; Bigge, Jeremy; Ulbright, Thomas M; Montgomery, Elizabeth



Intra-arterial Chemotherapy for Group C Retinoblastoma With Adjacent High-flow Infantile Hemangioma.  


Intra-arterial chemotherapy for retinoblastoma is an emerging technique that is being adopted at various centers worldwide. The authors report the first case of an infantile hemangioma that shunted flow during intra-arterial chemotherapy in a 4-month-old girl who presented with macular group C retinoblastoma. Excellent tumor response was noted despite only a fraction of the dose entering the central retinal artery. Further studies to examine intra-arterial chemotherapy's pharmacokinetics and dose-response relations are warranted in order to minimize the necessary exposure to chemotherapy. [Ophthalmic Surg Lasers Imaging Retina. 2013;44:490-492.]. PMID:24044714

Yonekawa, Yoshihiro; Orbach, Darren B; Trief, Danielle; Shah, Ankoor S; Vanderveen, Deborah K



Pulmonary angiomatosis and hemangioma in common dolphins (Delphinus delphis) stranded in Canary Islands.  


Vascular tumors and disorders, like angiomatosis, are rarely described in cetacean species. A retrospective histological study was carried out on lung samples from 35 common dolphins (Delphinus delphis) stranded in the Canary Islands coasts looking for morphological vascular changes and likely related causes. Twenty-five out of thirty-five (71%) common dolphins showed focal or multifocal angiomatosis-like lesions. A high association between this type of vascular proliferation and parasitic infestation was observed. In addition, a single pulmonary cavernous hemangioma not previously reported in common dolphins is presented. PMID:22467071

Díaz-Delgado, Josué; Arbelo, Manuel; Sacchini, Simona; Quesada-Canales, Óscar; Andrada, Marisa; Rivero, Miguel; Fernández, Antonio



Hemangioma of the mandible: case report with special emphasis on bone degradation  

Microsoft Academic Search

Purpose  Intraosseous hemangioma of the mandible is a rare tumor. In this report, we present a case with a particularly prominent osteolysis\\u000a and discuss the histological features of bone degradation.\\u000a \\u000a \\u000a \\u000a Materials and methods  We describe a 64-year-old female patient with a cystic tumor mass of the mandible leading to pathologic bone fracture. X-ray\\u000a analysis was suggestive for aneurysmatic bone cyst. A segment

Torsten Hansen; Martin Kunkel; Detlef Katenkamp; Sami Eletr; Wilfried Wagner



Photochemistry of the Giant Planets  

NASA Astrophysics Data System (ADS)

Photochemistry in the hydrogen-dominated atmospheres of Jupiter, Saturn, Uranus, and Neptune is interesting and complex despite the large heliocentric distances involved. Methane photochemistry dominates in the stratospheres of the giant planets; other "parent" molecules like H2O, NH3, and H2S are trapped in condensed phases and are confined to the troposphere. Methane photolysis initiates the production of complex hydrocarbons like C2H6, C2H2, C2H4, CH3C2H, C4H2, C6H6, and CH3 -- all of which have been detected on Jupiter and Saturn, and some of which have been detected on Uranus and Neptune. The photochemistry of ammonia and phosphine are coupled in the tropospheres of Jupiter and Saturn. Predicted products of this interaction include N2, N2H4, P4, P2H4, NH2PH2, with much lesser amounts of HCP, HCN, other nitriles like HC3N, CH3CN, and C2H3CN, and complex organo-nitrogen compounds like acetaldazine. None of these species have been definitively detected on the giant planets (except for HCN on Neptune and Jupiter). Water resides too deep in the tropospheres of the giant planets to interact with ultraviolet photons; however, oxygen is introduced to the upper atmospheres of the giant planets through external interaction with comets, interplanetary dust particles, and ring/satellite debris. The endproducts of the stratospheric oxygen photochemistry are CO, H2O, and CO2, with lesser amounts of H2CO, CH3OH, and CH3CHO. The possible tropospheric photochemistry of H2S on the giant planets is poorly understood due to a dearth of appropriate rate-coefficient information. Recent advances in our understanding of atmospheric photochemistry of giant planets, including that of extrasolar giant planets, will be reviewed.

Moses, J. I.



Giant necrotic pituitary apoplexy.  


Apoplexy of the pituitary gland is a rare complication of pituitary adenomas, involving hemorrhage with or without necrosis within the tumor. This condition may be either asymptomatic or may present with severe headache, visual impairment, ophthalmoplegia, and pituitary failure. Transsphenoidal surgery is the treatment of choice, and early intervention is usually required to ensure reversal of visual impairment. Reports of pituitary apoplectic lesions exceeding 60.0mm in diameter are very rare. A 39-year-old man with long-standing history of nasal congestion, decreased libido and infertility presented with a sudden onset of severe headache and diplopia. MRI of the head demonstrated a massive skull base lesion of 70.0×60.0×25.0mm, compatible with a giant pituitary macroadenoma. The lesion failed to enhance after administration of a contrast agent, suggesting complete necrotic apoplexy. Urgent surgical decompression was performed, and the lesion was resected via a transnasal transsphenoidal approach. Pathological analysis revealed evidence of necrotic pituitary apoplexy. At the 2 month follow-up, the patient had near-complete to complete resolution of his visual impairment. To the authors' knowledge, this report is unique as the patient demonstrated complete necrotic apoplexy and it underlines the diagnostic dilemma in such a case. PMID:23623615

Fanous, Andrew A; Quigley, Edward P; Chin, Steven S; Couldwell, William T



Inverse giant magnetoresistance (invited)  

SciTech Connect

Inverse giant magnetoresistance (GMR) is obtained in multilayers alternating two ferromagnetic layers {ital F}{sub 1} and {ital F}{sub 2} with different asymmetry of spin scattering, {alpha}{sub 1}{approx_gt}1 and {alpha}{sub 2}{lt}1. This is clearly demonstrated in the simple spin-valve system with perpendicular magnetization Fe{sub 1{minus}{ital x}}V{sub {ital x}}/Au/Co. With respect to Fe, the FeV alloys with {ital x}=0.18 and 0.29 exhibit an inversion of the spin scattering coefficients ({alpha}{sub Fe}{approx_gt}1, {alpha}{sub FeV}{lt}1) due to the change of the densities of states at the Fermi level. The inverse MR of FeV/Au/Co is studied as a function of FeV layer thickness and temperature and compared to calculations based on the Camley{endash}Barnas model. The data show that the inverse GMR is due to the bulk scattering within the FeV layer, which coexists with a substantial interface scattering favoring normal GMR. {copyright} {ital 1996 American Institute of Physics.}

Renard, J.; Bruno, P.; Megy, R.; Bartenlian, B.; Beauvillain, P.; Chappert, C.; Dupas, C.; Kolb, E.; Mulloy, M.; Prieur, J.; Veillet, P.; Velu, E. [Institut dElectronique Fondamentale, CNRS URA 022, Batiment 220, Universite Paris-Sud, 91405 Orsay Cedex (France)



Giant iatrogenic splenic pseudocyst.  


Partial splenic arterial embolization was used to treat hypersplenism in a 10-year-old boy with portal hypertension secondary to congenital hepatic fibrosis. After embolization the spleen remained enlarged, but the boy's platelet count increased and his variceal bleeding ceased. One month later, he returned with vomiting and an abdominal mass. Computed tomography showed a large cyst of the spleen with a small rim of residual splenic tissue. Percutaneous drainage with ultrasound guidance yielded 2,800 mL of brown fluid. Wedge-shaped infarctions are described early after splenic embolization, and these areas eventually fibrose and contract. In this case, the embolization resulted in splenic necrosis and liquefaction with pseudocyst formation. This unusual complication was effectively treated without surgery. PMID:2754589

Reynolds, M; Donaldson, J S; Vogelzang, R L



Hepatic Cell Adenoma: A Report of Four Cases  

PubMed Central

Four patients with hepatic cell adenoma have been treated at the UCLA Hospital since 1965. The most recent was a 22-year-old woman who underwent subtotal resection of a giant hepatic cell adenoma after an unusual and confusing clinical presentation. The tumor may be the largest reported to date and may have excreted metabolically-active substances. Increased familiarity with the varying clinical and radiographic presentations of these rare tumors may facilitate earlier diagnosis and management. ImagesFig. 1.Fig. 2.Fig. 3.Fig. 6.Fig. 7.

Albritton, David R.; Tompkins, Ronald K.; Longmire, William P.



Liver transplantation for recurrent hepatic adenoma.  


Hepatic adenoma (HA) is a rare indication for liver transplantation (LTx). So far 20 cases of LTx for HA are reported in PubMed. In rare cases HA presents as multiple hepatic adenomas or recurrent adenoma after initial liver resection and in such cases LTx is the only potential cure and prevents the risk of bleeding or cancer transformation into hepatocellular carcinoma. We report the case of a 56 years old lady who underwent a left hepatectomy for giant adenoma in 2005 and resection of segment V-VI for recurrence of liver adenoma in 2007. She developed a second recurrence of HA with 3 new lesions in the right liver in 2008. The patient underwent LTx. After 3 years the patient is alive with no evidence of disease. LTx is indicated in patients with HA in which resection is not technically feasible. PMID:23556048

Vennarecci, Giovanni; Santoro, Roberto; Antonini, Mario; Ceribelli, Cecilia; Laurenzi, Andrea; Moroni, Enrico; Burocchi, Mirco; Lepiane, Pasquale; Ettorre, Giuseppe Maria



Liver transplantation for recurrent hepatic adenoma  

PubMed Central

Hepatic adenoma (HA) is a rare indication for liver transplantation (LTx). So far 20 cases of LTx for HA are reported in PubMed. In rare cases HA presents as multiple hepatic adenomas or recurrent adenoma after initial liver resection and in such cases LTx is the only potential cure and prevents the risk of bleeding or cancer transformation into hepatocellular carcinoma. We report the case of a 56 years old lady who underwent a left hepatectomy for giant adenoma in 2005 and resection of segment V-VI for recurrence of liver adenoma in 2007. She developed a second recurrence of HA with 3 new lesions in the right liver in 2008. The patient underwent LTx. After 3 years the patient is alive with no evidence of disease. LTx is indicated in patients with HA in which resection is not technically feasible.

Vennarecci, Giovanni; Santoro, Roberto; Antonini, Mario; Ceribelli, Cecilia; Laurenzi, Andrea; Moroni, Enrico; Burocchi, Mirco; Lepiane, Pasquale; Ettorre, Giuseppe Maria



Giants of the Animal Kingdom  

NSDL National Science Digital Library

The following Web sites offer a quick tour of some of the planet's outsized inhabitants, from the relatively large (e.g. giant cave cockroach) to the just plain enormous (e.g. blue whale). The first Web site (1) is an Animal Planet Feature where visitors can meet giants of the past -- such as the giant komodo dragon and the giant sloth, and some of their smaller, modern-day cousins. The site contains lots of cool graphics, including 3-D rotatable images. The next stop is a commercial Web site advertising photography expeditions let by Amos Nachoum, a professional marine and wildlife photographer. All of the expeditions listed in the left-hand column include photo galleries where visitors can view terrific photos of Argentinian orcas, polar bears, blue whales, and more (2). The following Web site (3) is the online companion to "Toothwalkers: Giants of the Arctic Ice," a PBS Nature documentary about the giant saber-toothed Arctic walrus. Visitors will find special Web features, a video clip, and links to more information on the film and its gargantuan stars. The Discovery Channel introduces the elusive giant squid in this multimedia Web feature (4). Viewers will find loads of information on this amazing creature's natural history, literary history, and much more. The site also includes a trip on a virtual submersible, where you can learn more about life 2,000 feet below sea level. The next Web site is privately hosted by Chris "Capy" Head, and provides a great overview of the world's largest rodent, the undeniably adorable capybara (5). Visitors will find basic background information, links, a photo gallery, and more. Steve Bullington presents the giant cave roach in this privately-hosted Web site (6) as part of Bullington's Pet Arthropod Page. The site includes photos and detailed background information for this outsized roach (the world's largest species). The ostrich, which can claim the title of largest living bird (with the largest eggs, as well), gets its own page in this Web feature from PBS's Nature. Readers will find a quick overview of ostrich characteristics and natural history (7). And of course, what discussion of giant animals would be complete without mentioning the blue whale? In this Web site (8), the American Cetacean Society provides an informative fact sheet on "the largest mammal, possibly the largest animal, to ever inhabit the earth.


Giant polarization in high polymers  

NASA Astrophysics Data System (ADS)

In the course of studying the properties of highly conjugated polymers we found that long range orbital delocalization conferred unexpected properties. The presence of giant electronic orbitals made these materials electroactive yet very stable. A new mode of electronic polarizability resulted, a giant nomadic polarization, making these organic polymers among the most polarizable materials ever encountered. In addition, yet other attributes could be found, such as remanent magnetization, or metallic conductivity, or unusual pressure sensitivity. The giant orbital concept opens up new vistas of materials properties. We note that one can tailor giant orbital polymers to produce pure and highly stable super-dielectrics with high dielectric constants, from 6 to 100,000. Such materials will be useful in the electric power control, as in large motor starting capacitors and in power factor correction. They will doubtless also be useful in low visibility coatings, in obscuration, in EMP shielding, in microcircuitry, in transducers, and in parametric circuits. It remains to be proven if this new molecular mode, nomadic polarization, proves superior in energy storage and loss to that of the conventional “dipole orientation” mode. Preliminary results indicate an advantage for the new giant orbital materials.

Pohl, Herbert A.



Restoring transcription factor HoxA5 expression inhibits the growth of experimental hemangiomas in the brain.  


Hemangiomas are angiogenesis-dependent benign vascular tumors that can rupture and cause intracranial hemorrhages. We previously showed that the transcription factor homeobox A5 (HoxA5), which is absent in activated angiogenic endothelial cells can block angiogenesis. Here, we investigated whether restoring expression of HoxA5 blocks hemangioma growth by transplanting mouse hemangioendothelioma endothelial cells (EOMA) or HoxA5-expressing EOMA cells into the brains of mice. The EOMA cells induced brain hemangiomas characterized by large cystlike spaces lined by thin walls of endothelial cells surrounded by scant smooth muscle cells. When HoxA5-expressing EOMA cells were injected, lesion volumes were reduced between 5- and 20-fold compared with the EOMA control group (p < 0.05). Restoration of HoxA5 was associated with increased thrombospondin-2, which inhibits angiogenesis and reduced hypoxia-inducible factor 1alpha expression. These data suggest that restoring HoxA5 can attenuate experimental brain hemangioma development. PMID:19458547

Zhu, Yiqian; Cuevas, Ileana C; Gabriel, Rodney Allanigue; Su, Hua; Nishimura, Stephen; Gao, Peng; Fields, Alexander; Hao, Qi; Young, William L; Yang, Guo-Yuan; Boudreau, Nancy J



? Ophiuchi: Revisiting a Red Giant  

NASA Astrophysics Data System (ADS)

In only a decade, seismology of red-giant stars has grown from infancy to adulthood in the study of stellar structure and evolution. The stimulants for this accelerated growth have been space observations, first provided by the WIRE star-tracker and MOST, and continuing with CoRoT and Kepler, having detected oscillations in thousands of cool giants. However, almost all of the stars in this impressive sample are faint, with little known about their basic properties. Even reliable spectral classifications are lacking for many of them. MOST is the only space-based photometer capable of continuous observations of bright red giants for which we have independent constraints (e.g., spectroscopy) essential to extract the internal structure from the stars' p-modes.

Kallinger, T.; Matthews, J. M.; Guenther, D. B.; Gruberbauer, M.; Kuschnig, R.; Weiss, W. W.; MOST Team



Giant lobelias exemplify convergent evolution  

PubMed Central

Giant lobeliads on tropical mountains in East Africa and Hawaii have highly unusual, giant-rosette growth forms that appear to be convergent on each other and on those of several independently evolved groups of Asteraceae and other families. A recent phylogenetic analysis by Antonelli, based on sequencing the widest selection of lobeliads to date, raises doubts about this paradigmatic example of convergent evolution. Here I address the kinds of evidence needed to test for convergent evolution and argue that the analysis by Antonelli fails on four points. Antonelli's analysis makes several important contributions to our understanding of lobeliad evolution and geographic spread, but his claim regarding convergence appears to be invalid. Giant lobeliads in Hawaii and Africa represent paradigmatic examples of convergent evolution.



Giant lobelias exemplify convergent evolution.  


Giant lobeliads on tropical mountains in East Africa and Hawaii have highly unusual, giant-rosette growth forms that appear to be convergent on each other and on those of several independently evolved groups of Asteraceae and other families. A recent phylogenetic analysis by Antonelli, based on sequencing the widest selection of lobeliads to date, raises doubts about this paradigmatic example of convergent evolution. Here I address the kinds of evidence needed to test for convergent evolution and argue that the analysis by Antonelli fails on four points. Antonelli's analysis makes several important contributions to our understanding of lobeliad evolution and geographic spread, but his claim regarding convergence appears to be invalid. Giant lobeliads in Hawaii and Africa represent paradigmatic examples of convergent evolution. PMID:20074322

Givnish, Thomas J



Multiple peripheral typical carcinoid tumors of the lung: associated with sclerosing hemangiomas  

PubMed Central

Abstract This study presents a first case of multiple peripheral typical carcinoid tumors associated with sclerosing hemangiomas in the lung. A 52-year-old male presented with incidentally detected multiple pulmonary nodules on a simple chest X-ray during routine health check-up. A computed tomography (CT) scan of the chest showed multiple nodular lesions in the middle and lower lobes of the right lung. These were initially suspected as inflammatory lesions due to miliary tuberculosis. However, possibility of malignancy could not be excluded and right lower lobe lobectomy was performed. Histopathologically, some nodules including two largest nodules were composed of small round to spindle shaped cells with fine chromatin pattern, whereas the rest of the sclerotic nodules were composed of two epithelial cell types- surface cells and round cells. The final diagnosis of this case was multiple peripheral typical carcinoid tumors associated with sclerosing hemangiomas of the lung. For past three years of post-surgery follow up period, no new lesions or changes in the right middle lobe have been identified. Virtual Slides The virtual slide(s) for this article can be found here:



Current Concepts in the Management of Infantile Hemangiomas: Steroids, Beta-Blockers, or Surgery  

Microsoft Academic Search

\\u000a \\u000a \\u000a \\u000a \\u000a \\u000a  \\u000a \\u000a The term infantile hemangioma (IH) is now preferred to capillary hemangioma.\\u000a \\u000a \\u000a \\u000a  \\u000a \\u000a IHs are the most common benign tumors in early childhood and are the most common tumors of the eyelids and orbit in the first\\u000a years of life.\\u000a \\u000a \\u000a \\u000a \\u000a  \\u000a \\u000a They are characterized by three main phases:\\u000a \\u000a \\u000a \\u000a \\u000a • \\u000a \\u000a \\u000a A nascent phase\\u000a \\u000a \\u000a \\u000a • \\u000a \\u000a \\u000a A proliferative phase\\u000a \\u000a \\u000a \\u000a • \\u000a \\u000a \\u000a An involutional phase

François Codère; Julie Powell


Treatment of 28 patients with sclerosing hemangioma (SH) of the lung  

PubMed Central

Background Sclerosing hemangioma (SH) of the lung is a kind of rare pulmonary tumor. Preoperative diagnosis of this tumor is difficult and it is now generally accepted that SH of the lung is benign lesions and surgical excision alone is curative. Herein, we present our experiences of treating 28 patients with SH. Methods The medical records of 28 patients with SH from 1994 to 2010 at the Department of Thoracic Surgery in Beijing Chest Hospital were retrospectively reviewed. Results There were 3 male and 25 female patients with sclerosing hemangioma and 50% of the patients were asymptomatic. Preoperatively, all the patients had undergone CT of chest and 5 patients had undergone PET scan but 4 patients were misdiagnosed as malignancy. There was no operative mortality or tumor recurrence despite that three different operative methods were undertaken. Conclusions SH has a high incidence in middle-aged women. Most of SH is asymptomatic and the symptoms of SH are not related to the tumor size and distribution. The features of chest CT and PET are not specific. Bilateral or multiple lesions should not exclude the possibility of SH. Complete excision of lesion is a curable treatment method and there is no evidence to verify the need of adjuvant therapy.



Optical giant resonances in nuclear reactions  

Microsoft Academic Search

Physical reasons for optical giant resonances being a very general ; feature of nuclear reactions are discussed. Optical giant resonances, so ; familiar in the scattering of nucleons on nuclei, were also observed in elastic ; cross sections of composite particles scattered by nuclei and in reaction ; channels of a compound nucleus decay. That this optical giant resonance ;

K. Wildermuth; R. L. Carovillano



Giant lumbosacral schwannoma in a child  

PubMed Central

Small spinal intradural extramedullary schwannoma are a common occurrence in the middle aged. However, giant schwannoma in pediatric age group is rare. We report one such case of giant extradural lumbosacral schwannoma in an 8-year-old child. Clinical features, histopathology and management of giant schwannoma is discussed and the present literature reviewed.

Kataria, Rashim; Kurmi, Dhruba Jyoti; Mehta, Jayanti; Sinha, Virendra Deo



Giant lumbosacral schwannoma in a child.  


Small spinal intradural extramedullary schwannoma are a common occurrence in the middle aged. However, giant schwannoma in pediatric age group is rare. We report one such case of giant extradural lumbosacral schwannoma in an 8-year-old child. Clinical features, histopathology and management of giant schwannoma is discussed and the present literature reviewed. PMID:23248693

Kataria, Rashim; Kurmi, Dhruba Jyoti; Mehta, Jayanti; Sinha, Virendra Deo



Management of uterine giant myoma  

Microsoft Academic Search

Background  Giant myomas of the uterus are uncommon, particularly in developed countries.\\u000a \\u000a \\u000a \\u000a Case  This report illustrates a case of a woman with a bilobated giant myoma of the uterus weighed in total 27.7 kg. The patient\\u000a had an abdominal distension first noted 18 months before and the personal history evidenced difficulties in walking and tiredness.\\u000a Abdominal hysterectomy and bilateral salpingo-oophorectomy were carried out.\\u000a \\u000a \\u000a \\u000a Conclusions  The

Luigi Nappi; Maria Matteo; Silvio Giardina; Piergiorgio Rosenberg; Ugo Indraccolo; Pantaleo Greco



Prevalence of Hepatitis E Virus Antibodies in Patients with Chronic Hepatitis B and Chronic Hepatitis C  

Microsoft Academic Search

Objectives: To investigate the prevalence of hepatitis E virus (HEV) among patients with chronic hepatitis B and chronic hepatitis C, serum samples were collected between January and December 2004 from patients with chronic hepatitis B and chronic hepatitis C. Methods: There were 190 adult patients with chronic hepatitis B virus (HBV) and 174 with chronic hepatitis C virus (HCV) infection

A. Bayram; F. Eksi; M. Mehli; E. Sözen



Hepatic artery aneurysm in a patient with Behçet? disease and segmental pancreatitis developing after its embolization.  


Segmental pancreatitis is an unusual form of acute pancreatitis mostly seen in the head of pancreas. We present the CT findings of a segmental pancreatitis in the body and tail of the pancreas developed following endovascular embolization of a giant hepatic artery aneurysm and arterioportal fistula in a patient with Behçet's disease. PMID:10939494

Oto, A; Cekirge, S; Gülsün, M; Balkanci, F; Besim, A



Congenital Hepatic Vascular Malformations  

Microsoft Academic Search

\\u000a Congenital hepatic vascular malformations are rare entities that result in abnormal shunting of blood through the liver. Three\\u000a different types of shunting can occur: arteriovenous (hepatic artery to hepatic vein), arterioportal (hepatic artery to portal\\u000a vein) and portovenous (portal vein to hepatic vein). Malformations result from alterations in the formation of blood vessels\\u000a during fetal development and can occur as

Guadalupe Garcia-Tsao


Argon-pumped tunable dye laser therapy for facial port-wine stain hemangiomas in adults--a new technique using small spot size and minimal power  

SciTech Connect

A low power, argon-pumped tunable dye laser was used to deliver yellow light of 577 nm. Individual blood vessels within port-wine stain hemangiomas were treated with a 0.1-mm beam of light using 8 X magnification. This technique permits excellent resolution of facial and nuchal port-wine stain hemangiomas in adults without the adverse complications of textural change, permanent pigmentation abnormality, or hypertrophic scarring.

Scheibner, A.; Wheeland, R.G.



[Surgery for emphysematous giant bullae].  


We address 3 important keys to obtain successful outcomes in surgery for emphysematous giant bullae. It is the 1st step to select patients who might benefit from bullectomy based on functional imaging. The chest computed tomography (CT) and pulmonary perfusion scintigram provide information regarding with pulmonary vascular beds which could be recruited by bullectomy. In addition, dynamic-magnetic resonance imaging (MRI) during breathing can show a patient with paradoxical inflation of giant bulla during expiration, which means impairment of ventilation of the adjacent normal parenchyma, and is a promising sign for successful outcome of bullectomy. Second, it should be emphasized to perform a proper procedure in bullectomy. If a giant bulla has a wide bottom, it should be recommended to open the bulla and to plicate it by sutures without injury of vessels on the bottom of the bulla rather than simple bullectomy with staples. Finally, it is important to keep inflated lung avoiding atelectasis following operation by minimum pressure of suction. We show here sequential bullectomies on a 41-year-old male with chronic obstructive pulmonary disease (COPD) GOLD IV due to bilateral giant bullae and poor vascular reserve, and address our strategy described above. PMID:21491730

Chihara, K; Okita, K; Tamari, S; Hirano, M



Formation of the Giant Planets  

Microsoft Academic Search

The structure of a gaseous envelope surrounding a protoplanet has been investigated in connection with the formation of the giant planets. Under the assumptions of spherical symmetry and hydrostatic equilibrium, the structure has been calculated for the regions of Jupiter, Saturn, Uranus and Neptune. Energy transfer in the envelope has been taken into account precisely. When the core mass increases

Hiroshi Mizuno



Giant Serpentine Aneurysms: Multidisciplinary Management  

PubMed Central

Summary Sixty-five cases of intracranial giant serpentine aneurysms (GS?s), including 61 cases reported in the literature and four additional cases presented in this study were reviewed. The clinical presentation, possible causes, natural history, and especially management of GSAs are discussed with emphasis on the need for aggressive intervention and multidisciplinary management.

Anshun, W.; Feng, L.; Daming, W.



Giant magnetoresistance in electrodeposited films  

Microsoft Academic Search

Electrodeposition is one of the simpler and cheaper processes available for the fabrication of thin metal films. Recent developments have made it possible to electrodeposit a wide range of nanostructured materials, including many that exhibit giant magnetoresistance (GMR). We review progress in the growth and characterization of such films, starting with electrodeposited ferromagnetic metal\\/non-magnetic metal superlattices in which the individual

W. Schwarzacher; D. S. Lashmore



Giant Hydronephrosis – A Diagnostic Dilemma  

Microsoft Academic Search

We report a complex case in which the left kidney had undergone giant hydronephrotic change after chronic obstruction at the vesicoureteric junction. Minor blunt abdominal trauma caused rupture of the parenchyma of this expanded and dilated kidney, with bleeding into its collecting system. The mixture of blood and urine remained contained within the kidney’s structural layers, so producing a tense,

J. Mountney; C. R. Chapple; A. G. Johnson



Halothane hepatitis  

PubMed Central

This report describes five cases of hepatocellular injury following halothane anesthesia. Four patients had multiple exposures to the anesthetic. Three of the five died from submassive to massive liver cell necrosis. The two survivors developed jaundice and/or dark urine following each exposure to halothane; liver biopsy in one showed centrilobular and linear areas of necrosis. Fever, anorexia, nausea, vomiting, abdominal pain and jaundice were present in all cases. In the two survivors the prothrombin time was less than 20 seconds throughout the course of the disease, whereas in the three who died the prothrombin time was more than 20 seconds from the onset. The English literature to the end of 1971 is reviewed. Approximately 600 cases of halothane-related hepatitis have been reported ImagesFIG. 1FIG. 2FIG. 3FIG. 4FIG. 5

Qizilbash, Ali H.



Formation of Gas Giant Planets  

NASA Astrophysics Data System (ADS)

The observed physical properties and orbits of giant planets, models of their internal structure and observations of protoplanetary disks provide constraints on the formation of gas giant planets. The four largest planets in our Solar System contain considerable quantities of hydrogen and helium; these gasses could not have condensed into solid planetesimals within the protoplanetary disk. Jupiter and Saturn are mostly hydrogen and helium, but have larger percentages of heavier elements than does the Sun. Neptune and Uranus are primarily composed of elements heavier than helium. The transiting extrasolar planet HD 149026 b, which is slightly more massive than is Saturn, appears to have comparable amounts of light gases and heavy elements. The other observed transiting exoplanets are primarily hydrogen and helium, but may contain supersolar abundances of heavy elements. Spacecraft flybys and observations of satellite orbits provide estimates of the gravitational moments of the giant planets in our Solar System, which in turn provide information on the internal distribution of matter within Jupiter, Saturn, Uranus and Neptune. Atmospheric thermal structure and heat flow measurements constrain the interior temperatures of these planets. Extrasolar planets orbiting very close to their stars almost certainly formed at larger distances and migrated inwards as a consequence of gravitational interactions with their protoplanetary disks. The preponderance of evidence supports the core nucleated gas accretion model. According to this model, giant planets begin their growth by the accumulation of small solid bodies, as do terrestrial planets. However, unlike terrestrial planets, the giant planet cores grow massive enough to accumulate substantial amounts of gas before the protoplanetary disk dissipates. The primary question regarding the core nucleated growth model is under what conditions can planets develop cores sufficiently massive to accrete gas envelopes within the lifetimes of typical gaseous protoplanetary disks.

Lissauer, Jack J.; D'Angelo, Gennaro



Multiplication of hepatitis B virus in fulminant hepatitis B  

Microsoft Academic Search

The presence in serum of hepatitis B e antigen (HBeAg) and hepatitis B virus DNA, which are each regarded as reflecting multiplication of hepatitis B virus, were looked for one to five days after the onset of hepatic encephalopathy in 64 patients with fulminant hepatitis B. HBeAg and hepatitis B virus DNA were found in the serum of only 24

C Brechot; J Bernuau; V Thiers; F Dubois; A Goudeau; B Rueff; P Tiollais; J P Benhamou



Evaluation of texture features in hepatic tissue characterization from non-enhanced CT images.  


Aim of this paper is to evaluate the diagnostic contribution of various types of texture features in discrimination of hepatic tissue in abdominal non-enhanced Computed Tomography (CT) images. Regions of Interest (ROIs) corresponding to the classes: normal liver, cyst, hemangioma, and hepatocellular carcinoma were drawn by an experienced radiologist. For each ROI, five distinct sets of texture features are extracted using First Order Statistics (FOS), Spatial Gray Level Dependence Matrix (SGLDM), Gray Level Difference Method (GLDM), Laws' Texture Energy Measures (TEM), and Fractal Dimension Measurements (FDM). In order to evaluate the ability of the texture features to discriminate the various types of hepatic tissue, each set of texture features, or its reduced version after genetic algorithm based feature selection, was fed to a feed-forward Neural Network (NN) classifier. For each NN, the area under Receiver Operating Characteristic (ROC) curves (Az) was calculated for all one-vs-all discriminations of hepatic tissue. Additionally, the total Az for the multi-class discrimination task was estimated. The results show that features derived from FOS perform better than other texture features (total Az: 0.802+/-0.083) in the discrimination of hepatic tissue. PMID:18002811

Valavanis, Ioannis K; Mougiakakou, Stavroula G; Nikita, Alexandra; Nikita, Konstantina S



Hepatitis B Virus in Pregnancy  


What is hepatitis B virus? Hepatitis B virus is one of a number of hepatitis viruses that attack and damage the liver. Other types include hepatitis A, ... upper-right side of your abdomen. How is hepatitis B transmitted? Hepatitis B virus is passed from ...


Orbital fibrous histiocytoma mimicking cavernous hemangioma on dynamic contrast-enhanced MRA imaging.  


Orbital lesions include a broad spectrum of tumors, vascular abnormalities, and inflammatory conditions. High-resolution imaging has become an invaluable tool toward formulating an accurate diagnosis, and facilitates proper counseling regarding appropriate interventions. Imaging may guide whether partial excision to minimize damage to orbital structures, or en bloc removal to prevent potential recurrence, as seen in mesenchymal tumors, is indicated., Recently, dynamic contrast-enhanced magnetic resonance angiography (MRA) has demonstrated use in helping differentiate orbital vascular lesions. This imaging modality uses rapid MRI acquisition to provide noninvasive, dynamic flow information with high spatial resolution. However, even with modern imaging, reaching a diagnosis prior to histopathological analysis can be challenging. We present a case of orbital fibrous histiocytoma that appeared nearly identical to cavernous hemangioma on dynamic contrast-enhanced MRA. PMID:22836792

Warner, Evan J; Burkat, Cat N; Gentry, Lindell R



Cardiac hemangioma located at the apex of the left ventricle: a rare case report.  


We report the case of a 67-year-old man who was found to have asymptomatic murmurs during his health check-up. Echocardiography revealed a mobile spherical mass in the left ventricle (LV), whereas magnetic resonance imaging (MRI) study revealed a well-circumscribed heterogeneous mass in the LV with its base attached to the LV apex. To the best of our knowledge, such a case of hemangioma, particularly its rare location at the apex of the LV, and its asymptomatic conduction disturbance has not yet been reported in the medical literature. Because of successful surgical intervention, the patient is in good health without any further tumor recurrence at 24 months after the diagnosis. PMID:23397831

Lin, C T; Lee, C Y; Hong, G J; Tsai, Y T; Lin, C Y; Ke, H Y; Tsai, C S


Giant Herbig-Haro Flows  

NASA Astrophysics Data System (ADS)

We present the discovery of a number of Herbig-Haro flows which extend over parsec-scale distances. The largest of these is the well known HH 111 jet complex, which is shown, through CCD images and a proper motion study, to have an angular extent of almost one degree on the sky, corresponding to 7.7 pc, making it the largest known HH flow. In our imaging survey we also found that T Tauri is at the center of a huge bipolar HH flow, HH 355, with a total extent of 38 arcmin, corresponding to 1.55 pc, and aligned with the axis of the tiny HH 255 flow surrounding the infrared companion T Tau S. We additionally have found a number of other giant HH flow candidates, including HH 315 at PV Cep, HH 41/295 at Haro 5a/6a, HH 300 in Bl8w, HH 354 in Li 165, HH 376 in Li 152, and HH 114/115 and HH 243/244/245/179 in the X Orionis molecular ring. It thus appears that it is common for HH flows to attain parsec-scale dimensions. The ubiquity of parsec-scale HH flows profoundly alters our view of the impact of young stars on their environment. Giant flows have dynamical ages comparable to the duration of the accretion phase of the sources, and provide a fossil record of their mass loss and accretion history. Multiple internal working surfaces and their S-shaped point symmetry provide evidence for variability of ejection velocity and orientation of the source jets. Giant HH flows are either longer or comparable in length to associated CO outflows, providing evidence for unified models in which HH flows power CO flows. Many giant flows have burst out of their source cloud cores and are dissociating molecules and injecting momentum and kinetic energy into the interclump medium of the host clouds. They contribute to the UV radiation field, and may produce C I and C ii in cloud interiors. Giant flows may contribute to the chemical rejuvenation of clouds, the generation of turbulent motions, and the self-regulation of star formation. The terminal working surfaces of giant flows may be used to probe the nature of the interclump medium of clouds.

Reipurth, Bo; Bally, John; Devine, David



Radiotherapy of Painful Vertebral Hemangiomas: The Single Center Retrospective Analysis of 137 Cases  

SciTech Connect

Purpose: An evaluation of dose-response relationship and an attempt to define predictive factors. Methods and Materials: A total of 137 cases of painful vertebral hemangioma irradiations (101 patients). Fraction dose (fd) varied from 2 to 15 Gy (123 fractionated and 14 radiosurgical treatments), and total dose (TD) from 8 to 30 Gy (111 cases irradiated with fd of 2 GY to TD of 24 Gy). We evaluated pain relief, changes in analgesic requirements, and reossification. Results: Means of pain relief 1, 6, 12, and 18 months after radiotherapy (defined as a decrease of primary pain level expressed in percent) were 60.5%, 65.4%, 68.3%, and 78.4%, respectively. Proportion of patients with no need for analgesics and patients using tramadol were 39%, 40%, 44%, 57%, and 20%, 17%, 22%, and 11% in these times. The proportion of patients experiencing complete/partial pain relief changed from 36/48% 1 month, to 64/22% 1.5 years after radiotherapy. No impact of radiotherapy on reossification was found. The positive impact of fd and TD increase for analgesics uptake reduction and pain relief was found. An increase of the fd by 1 Gy results in 27% chance of analgesics uptake reduction and 3.8% reduction of pain, whereas 14% analgesics uptake reduction and 2.2% of pain reduction in case of the TD. The predictive factors improving results were found: female gender, older age, better performance states (the chance of the lower analgesic treatment decreases over 2.5 times in comparison to the higher Zubrod degree), bigger Hb concentration, shorter symptoms duration and lower analgesics uptake before radiotherapy. Conclusions: The obtained data support the efficacy of radiotherapy in improving pain secondary to vertebral hemangioma, with the degree of pain amelioration being related to increasing fd and TD. The positive predictive factors were defined: female gender, older age, better performance status, increased Hb concentration, shorter symptoms duration, and lower analgesics uptake before radiotherapy.

Miszczyk, Leszek, E-mail: [Radiotherapy Department, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice (Poland); Tukiendorf, Andrzej [Cardiff Research Consortium, The MediCentre Eastgate House, Cardiff, South Glamorgan (United Kingdom)



The role of ?-adrenergic receptor signaling in the proliferation of hemangioma-derived endothelial cells  

PubMed Central

Background Infantile hemangioma (IH) is a benign vascular neoplasm that arises from the abnormal proliferation of endothelial cells and enhanced angiogenesis. Recently, propranolol has been found to be effective in the management of IH, suggesting that ?-adrenergic receptors (?-ARs) may play an important role in the pathogenesis of IH. Results In the present study, we investigated the ?-adrenergic signaling that is associated with hemangioma-derived endothelial cell (HemEC) proliferation. The results showed that both ?1- and ?2-ARs were expressed in HemECs. Stimulation of the ?-ARs by isoprenaline induced cell proliferation and elevation of second messenger cAMP levels. The proliferation-promoting action of isoprenaline was abolished by a ?1-selective antagonist and was more effectively abolished by a ?2-selective antagonist; the mechanism for the action of the antagonists was a G0/G1 phase cell cycle arrest which was associated with decreased cyclin D1, CDK-4, CDK-6 and phospho-Rb expression. Pre-treatment of the cells with VEGFR-2 or ERK inhibitors also prevented the isoprenaline-mediated proliferation of cells. In agreement with the involvement of ?-ARs and VEGFR-2 in the HemEC response, ?-AR antagonists and the VEGFR-2 inhibitor significantly attenuated isoprenaline-induced ERK phosphorylation. Moreover, treating the cells with isoprenaline markedly increased VEGF-A expression and VEGFR-2 activity in a ?2-AR-dependent manner. Conclusions We have demonstrated that the activation of the ?-ARs in the ERK pathway may be important mechanisms in promoting HemEC growth. Furthermore, stimulation of the ?-AR may transactivate VEGFR-2 signaling and further increase HemEC proliferation.



Infantile hemangioma: treatment with short course systemic corticosteroid therapy as an alternative for propranolol.  


Infantile hemangiomas (IHs) are increasingly being treated with propranolol or other beta-blockers, but before this therapeutic option was available, oral glucocorticosteroids (GCSs) were the criterion standard treatment and are still the alternative modality in problematic cases. Nevertheless, there is no standard treatment protocol for the dose and duration of GCSs. Long-term treatment with GCSs is associated with unwanted side effects such as growth suppression, behavioral changes, and reflux. Twenty-one children with troublesome IHs were treated according to an algorithm with 3 mg/kg/day of oral prednisolone divided three times per day with varying duration and number of GCS courses. Two blinded investigators independently interpreted therapy results using the Hemangioma Activity Score (HAS). Side effects were determined according to reports in patient charts and parental questionnaires. The median duration of a short course of GCSs was 2 weeks (range 1-6 weeks). The number of courses was 2 (range 1-5). The median cumulative dose was 91 mg/kg. Growth stabilized in all patients, with a good response (>50% reduction in HAS) in 62% and a favorable response (30-50% reduction is HAS) in 23%. Twelve of the 21 children (57%) had minor side effects. Persistent side effects did not occur. Intermittent short course, systemic, high-dose GCS therapy is an effective and safe treatment modality for IH, with a substantially lower cumulative dose of GCSs compared to prolonged therapy and no major side effects. This treatment is an alternative in cases in which propranolol fails or is contraindicated. PMID:22958179

Nieuwenhuis, Klaske; de Laat, Peter C J; Janmohamed, Sherief R; Madern, Gerard C; Oranje, Arnold P



What Is Hepatitis?  


... WHO .int site Submit Advanced search What is hepatitis? Online Q&A Updated June 2013 Q: What ... cause liver disease, they vary in important ways. Hepatitis A virus (HAV) is present in the faeces ...


Literacy Measure B - Hepatitis  

Center for Drug Evaluation (CDER)

... Literacy Measure B - Hepatitis. HEPATITIS. Frequency. Percent. Valid Percent. Cumulative Percent. Valid, Correct, 838, 92.7, 92.7, 92.7. ... More results from


Viral Hepatitis Therapies  


... Cancer Liaison Program Cardiovascular Information Diabetes Information - Viral Hepatitis Therapies Click on drug brand name for additional information. Approved Treatments for Hepatitis B Brand Name Generic Names Manufacturer Name Indication ...


Imaging of giant radio galaxies  

NASA Astrophysics Data System (ADS)

Giant radio galaxies (GRGs) are the single largest objects in the universe and are extremely useful for studying a number of astrophysical problems. Their linear sizes are greater than a few Mpc. These sources often show two distinct bright features called lobes on either side of the host galaxy position and separated from it by several kpc. Since they have expanded to such large sizes, they are thought to be the end-point of radio galaxy evolution and provide important constraints to evolutionary models. They extend well past the environment of their host galaxy and act as direct probes of the intergalactic medium. A programme for Optical CCD imaging and observations at a few radio frequencies for some of the giant radio galaxies is presented.

Singh, Mahendra


A giant peritoneal loose body.  


Peritoneal loose bodies (PLBs) are usually discovered incidentally during laparotomy or autopsy. A few cases of giant PLBs presenting with various symptoms have been reported in the literature. Here, we describe a case of a giant PLB incidentally found in the pelvic cavity of a 50-year-old man. Computed tomography revealed a free ovoid mass in the pelvic cavity that consisted of central dense, heterogeneous calcifications and peripheral soft tissue. The mass was an egg-shaped, hard, glistening concretion measuring 7.5×7.0×6.8 cm and weighing 160 g. This concretion consisted of central necrotic fatty tissue surrounded by concentrically laminated, acellular, fibrous material. Small PLBs usually do not require any specific treatment. However, if PLBs cause alimentary or urinary symptoms due to their large size, surgical removal may be recommended. It is essential for clinicians to be aware of this entity and its characteristic features to establish the correct diagnosis. PMID:24009634

Kim, Hyun-Soo; Sung, Ji-Youn; Park, Won Seo; Kim, Youn Wha



Why do stars become giants?  

NASA Astrophysics Data System (ADS)

In this paper I explain why stars become giants; and I review earlier work, indicating why there has been so little consensus on this question despite over fifty years of investigation. The mechanism causing giantness is not simple. It involves a complex natural conspiracy in which there are four critical roles. These roles are played by eight different physical effects (see Tab. I). Dans cette étude,j'explique pourquoi les étoiles deviennent géantes;j'analyse les publications préalables, et j'indique pourquoi il y avait si peu d'accord sur cette question, malgré plus de cinquante années de recherche. Le mécanisme qui cause le "géantisme" n'est pas simple. Cela implique une "conspiration" naturelle mais très complexe, dans laquelle il y a quatres rôles essentiels. Ces rôles sont joués par huit effets physiques distincts (voir Tab. I).

Whitworth, Anthony


Proteorhodopsin genes in giant viruses.  


Viruses with large genomes encode numerous proteins that do not directly participate in virus biogenesis but rather modify key functional systems of infected cells. We report that a distinct group of giant viruses infecting unicellular eukaryotes that includes Organic Lake Phycodnaviruses and Phaeocystis globosa virus encode predicted proteorhodopsins that have not been previously detected in viruses. Search of metagenomic sequence data shows that putative viral proteorhodopsins are extremely abundant in marine environments. Phylogenetic analysis suggests that giant viruses acquired proteorhodopsins via horizontal gene transfer from proteorhodopsin-encoding protists although the actual donor(s) could not be presently identified. The pattern of conservation of the predicted functionally important amino acid residues suggests that viral proteorhodopsin homologs function as sensory rhodopsins. We hypothesize that viral rhodopsins modulate light-dependent signaling, in particular phototaxis, in infected protists. PMID:23036091

Yutin, Natalya; Koonin, Eugene V



Proteorhodopsin genes in giant viruses  

PubMed Central

Viruses with large genomes encode numerous proteins that do not directly participate in virus biogenesis but rather modify key functional systems of infected cells. We report that a distinct group of giant viruses infecting unicellular eukaryotes that includes Organic Lake Phycodnaviruses and Phaeocystis globosa virus encode predicted proteorhodopsins that have not been previously detected in viruses. Search of metagenomic sequence data shows that putative viral proteorhodopsins are extremely abundant in marine environments. Phylogenetic analysis suggests that giant viruses acquired proteorhodopsins via horizontal gene transfer from proteorhodopsin-encoding protists although the actual donor(s) could not be presently identified. The pattern of conservation of the predicted functionally important amino acid residues suggests that viral proteorhodopsin homologs function as sensory rhodopsins. We hypothesize that viral rhodopsins modulate light-dependent signaling, in particular phototaxis, in infected protists. This article was reviewed by Igor B. Zhulin and Laksminarayan M. Iyer. For the full reviews, see the Reviewers’ reports section.



Prevention of viral hepatitis  

Microsoft Academic Search

Opinion statement  Despite the availability of vaccines against hepatitis A and B, acute viral hepatitis due to these agents continues to be\\u000a among the most commonly reported notifiable infectious diseases in the United States. Currently available hepatitis A and\\u000a B vaccines are highly immunogenic and well tolerated, but vaccine coverage needs to be expanded. Use of the hepatitis A vaccine\\u000a in

Raymond S. Koff



Hepatitis C in pregnancy.  


Hepatitis C is a worldwide health problem affecting men and women of all ages. In young pregnant women, however, the existence of hepatitis C presents a set of unique issues for the mother and the child. For the mother, therapeutic and medical decisions for hepatitis C are affected by pregnancy. For the child, transmission of hepatitis C from the mother can occur. Identification of risk factors for mother-to-child transmission and prevention of this transmission are the foremost concerns. PMID:15701298

Su, Grace L



Hepatitis C in pregnancy  

Microsoft Academic Search

Hepatitis C is a worldwide health problem affecting men and women of all ages. In young pregnant women, however, the existence\\u000a of hepatitis C presents a set of unique issues for the mother and the child. For the mother, therapeutic and medical decisions\\u000a for hepatitis C are affected by pregnancy. For the child, transmission of hepatitis C from the mother

Grace L. Su



Giant magnetoresistance in silicene nanoribbons.  


By performing first-principle quantum transport calculations, we predict a giant magnetoresistance in zigzag silicene nanoribbons (ZSiNRs) connecting two semi-infinite silicene electrodes through switch of the edge spin direction of ZSiNRs. Spin-filter efficiency of both the antiferromagnetic and ferromagnetic ZSiNRs is sign-changeable with the bias voltage. Therefore, potential application of silicene in spintronics devices is suggested. PMID:22508440

Xu, Chengyong; Luo, Guangfu; Liu, Qihang; Zheng, Jiaxin; Zhang, Zhimeng; Nagase, Shigeru; Gao, Zhengxiang; Lu, Jing



Congenital giant hydronephrosis in adults.  


Giant hydronephrosis is the term designating the presence of more than 1,000 ml. of fluid in the collecting system. Of 4 cases of congenital hydronephrosis found over a three-year period at the Ochsner Medical Institutions, 2 were associated with unsuspected carcinomas. Hydronephrosis may first be detected as a mass palpable in the abdomen and displacing the intestines on gastrointestinal films. Excretory urography, retrograde pyelography, and angiography confirm the diagnosis. The treatment of choice is nephrectomy. PMID:919130

Ochsner, M G; Fuselier, H A; Brannan, W; Simo, J B



Isotopic ratios in giant planets  

NASA Astrophysics Data System (ADS)

The accuracy of spectrometric measurements of isotopic ratios in giant planets, and implications on the formation of giant planets are discussed. Derivations of D/H in Jupiter and Saturn form CH3D conflict with derivations from HD. Uncertainties in the interpretation come from the difficulty in estimating the fractionation factor between CH3D and CH4, and from scattering effects in the radiative transfer within HD and H2 absorption lines. However, deuterium abundance in the primordial solar nebula 4.6 billion yr ago can be estimated. Data suggest that D/H is enhanced in Uranus compared to Jupiter and Saturn, in agreement with a scenario of inhomogeneous formation of giant planets. The C12/C13 value in Jupiter from Voyager measurements suggests a value significantly higher than the terrestrial value, but conflicts with the value derived from ground based measurements, which agrees with the terrestrial value. The N14/N15 value is compatible with the terrestrial value.

Gautier, D.


Giant cell tumor of bone.  


Giant cell tumor (GCT) of bone is one type of giant cell-rich lesion of bone. This benign mesenchymal tumor has characteristic multinuclear giant cells. Mononuclear stromal cells are the physiologically active and diagnostic cell type. Most GCTs are located in the epiphyseal regions of long bones. The axial skeleton-primarily the sacrum-is a secondary site of involvement. Most patients present with pain, swelling, joint effusion, and disability in the third and fourth decades of life. Imaging studies are important for tumor staging and radiographic grading. Typically, these clinically active but slow-growing tumors are confined to bone, with relatively well-defined radiographic borders. Monostotic disease is most common. Metastatic spread to the lungs is rare. Extended intralesional curettage with or without adjuvant therapy is the primary treatment choice. Local recurrence is seen in ? 20% of cases, and a second local intralesional procedure is typically sufficient in cases that are detected early. Medical therapies include diphosphonates and denosumab. Denosumab has been approved for use in osteoporosis as well as breast and prostate cancer metastatic to bone. Medical therapy and radiotherapy can alter the management of GCT of bone, especially in multifocal disease, local recurrences, and bulky central/axial disease. PMID:23378375

Raskin, Kevin A; Schwab, Joseph H; Mankin, Henry J; Springfield, Dempsey S; Hornicek, Francis J



Clonal X-chromosome inactivation suggests that splenic cord capillary hemangioma is a true neoplasm and not a subtype of splenic hamartoma.  


Splenic hamartoma is a rare tumor-like lesion composed of structurally disorganized red pulp elements. It has been hypothesized that two other splenic lesions, cord capillary hemangioma and myoid angioendothelioma, may fall within the spectrum of splenic hamartoma, simply representing morphological variants. In this study, we compared the vascular and stromal composition of cord capillary hemangioma and myoid angioendothelioma with those of classical hamartoma. In addition, we assessed the clonal vs polyclonal nature of the lesions in nine female cases by performing clonality analysis for X-chromosome inactivation at the human androgen receptor locus (HUMARA) on laser-assisted microdissected samples. In 15 of 17 cases, increased reticulin and/or collagen content was observed. The classical hamartoma cases showed a vasculature predominantly composed of CD8+ CD31+ CD34- splenic sinuses, whereas cases of cord capillary hemangioma and myoid angioendothelioma contained many CD8- CD31+ CD34+ cord capillaries, but very little CD8+ vasculature. All cases lacked expression of D2-40 and Epstein Barr virus-encoded RNA. All cases showed a proliferation index of ?5% by Ki-67. Cases of classical hamartoma lacked significant perisinusoidal expression of collagen IV and low-affinity nerve growth factor receptor. Both markers were variably expressed in the other lesions. Increased CD163-positive histiocytes were found in four cases (three cord capillary hemangiomas and one myoid angioendothelioma). HUMARA analysis was informative in all nine tested cases, of which three cases showed a non-random X-chromosome inactivation pattern, indicating clonality. All three clonal cases were cord capillary hemangiomas. Our study has shown that in spite of considerable morphologic heterogeneity and overlapping features, classical hamartoma and cord capillary hemangioma and myoid angioendothelioma are different in terms of their vascular and stromal composition. Clonality analysis supports a true neoplastic origin for the cord capillary hemangioma. A larger study using additional immunohistochemical and molecular studies is necessary to further evaluate the biological significance of the current findings. PMID:20852592

Chiu, A; Czader, M; Cheng, L; Hasserjian, R P; Wang, M; Bhagavathi, S; Hyjek, E M; Al-Ahmadie, H; Knowles, D M; Orazi, A



Clinical observation on the treatment of hemangioma by CO2 laser supplemented with He-Ne laser  

NASA Astrophysics Data System (ADS)

Sixty-six cases of hemangioma were treated with CO2 laser alone (22 cases as a control group), or CO2 laser supplemented with He-Ne laser (44 cases of the treated group). Optimum power dosage was first sought on normal volunteers. Arteriolar vasculature and lymphatics were blocked 3 - 5 times with procaine hydrochloride (5:1) to minimize local blood congestion. Results show that the healing rate of the treated group was significantly higher than that of the control group (X3 equals 3.92, P < 0.05). Eleven cases (50%) were complicated with exudation in the control as compared with 3 cases (6.8%) in the treated group (P < 0.01). Of the 18 cases completely cured in the control group, the number of treatments averaged at 11.4 times, while of the 39 cases completely cured in the treated group, the average number of treatments was 5.9 times, which is also statistically significant (P < 0.01). It is considered that CO2 laser supplemented with He-Ne laser is superior than CO2 laser alone for the treatment of hemangioma. Furthermore, it is also proposed that the supplement of copper and Chinese herbal medicines may prevent the incidence of recurrence. Laser was used for the treatment of hemangioma in our country during the 1980s. In foreign literature, there were several reports using Nd:YAG and copper vapor laser for the treatment of agniomasimplex and nevus flammeus. Ar+ laser agglomeration was commonly used for the treatment of angioma conjunctive in our country, but the use of CO2 laser for the treatment of angioma epiderma is not well documented. We wish to report the use of CO2 laser supplemented with He-Ne laser for the treatment of hemangioma in our hospital from April 1988 to December 1989.

Zhao, Zhigui



Determination of ganglioside composition and structure in human brain hemangioma by chip-based nanoelectrospray ionization tandem mass spectrometry  

Microsoft Academic Search

We report here on a preliminary investigation of ganglioside composition and structure in human hemangioma, a benign tumor\\u000a in the frontal cortex (HFC) in comparison to normal frontal cortex (NFC) tissue using for the first time advanced mass spectrometric\\u000a methods based on fully automated chip-nanoelectrospray (nanoESI) high-capacity ion trap (HCT) and collision-induced dissociation\\u000a (CID). The high ionization efficiency, sensitivity and

Catalin Schiopu; Corina Flangea; Florina Capitan; Alina Serb; Željka Vukeli?; Svjetlana Kalanj-Bognar; Eugen Sisu; Michael Przybylski; Alina D. Zamfir



Lithospheric footprints of giant orogenic gold systems  

Microsoft Academic Search

Small orogenic gold deposits have the same deposit-scale geological and geochemical features as those that characterise giant orogenic gold systems (>16 Moz Au). Therefore, a broader-scale approach is needed to identify the critical controls on giant deposits and their disproportionate distribution throughout time and space. Ages of giant gold systems cluster around well-defined periods of lithospheric growth at continental margins,

F. P. Bierlein; D. I. Groves; R. J. Goldfarb; A. B. Christie


Electrophysiological Recordings from the Giant Fiber System  

PubMed Central

The giant fiber system (GFS) of Drosophila is a well-characterized neuronal circuit that mediates the escape response in the fly. It is one of the few adult neural circuits from which electrophysiological recordings can be made routinely. This article describes a simple procedure for stimulating the giant fiber neurons directly in the brain of the adult fly and obtaining recordings from the output muscles of the giant fiber system.

Allen, Marcus J



Spontaneous thrombosis in giant intracranial aneurysms.  

PubMed Central

Twelve patients in a series of 22 with giant intracranial aneurysms demonstrated neuroradiological features of partial or total spontaneous intra-aneurysmal thrombosis. The presence of this intra-aneurysmal clot significantly altered the computed tomographic appearance of the giant aneurysm. Massive intra-aneurysmal thrombosis did not protect against subarachnoid haemorrhage and the likelihood of rupture of a clot containing giant aneurysm was not significantly different from that of a non-thrombosed giant aneurysm. Although parent artery occlusion from a thrombosed giant aneurysm, and massive aneurysmal thrombosis leading to the formation of giant serpentine aneurysm were documented, these are rare epiphenomena. The risk of embolisation from a partially thrombosed giant aneurysm, which was documented in one case, would appear to be greater than that from a non-thrombosed giant aneurysm. The findings in this series, and a review of literature, suggest that the presence of intra-aneurysmal clot in giant intracranial aneurysms has little prognostic significance and does not alter the management or outcome after treatment. Images

Whittle, I R; Dorsch, N W; Besser, M



Pathogenesis of Hepatic Encephalopathy  

PubMed Central

Hepatic encephalopathy can be a serious complication of acute liver failure and chronic liver diseases, predominantly liver cirrhosis. Hyperammonemia plays the most important role in the pathogenesis of hepatic encephalopathy. The brain-blood barrier disturbances, changes in neurotransmission, neuroinflammation, oxidative stress, GABA-ergic or benzodiazepine pathway abnormalities, manganese neurotoxicity, brain energetic disturbances, and brain blood flow abnormalities are considered to be involved in the development of hepatic encephalopathy. The influence of small intestine bacterial overgrowth (SIBO) on the induction of minimal hepatic encephalopathy is recently emphasized. The aim of this paper is to present the current views on the pathogenesis of hepatic encephalopathy.

Ciecko-Michalska, Irena; Szczepanek, Malgorzata; Slowik, Agnieszka; Mach, Tomasz



Cavernous Hemangiomas  


... down year after year. PATIENT PAGE Section Editors David C. Spencer, MD Steven Karceski, MD e64 Copyright © ... evaluation by a person PATIENT PAGE Section Editors David C. Spencer, MD Steven Karceski, MD e66 Copyright © ...


The Giant Panda is a Bear  

Microsoft Academic Search

EXOTIC habitat, rarity, striking coloration, and an appealing countenance have combined to surround the giant panda (Ailuropda melanoleuca) with an aura of mystery unmatched by most other mammals. Nonetheless, we really know little about the species, a lack perhaps best exemplified by the long-standing controversy about the giant panda's phylogenetic position among the arctoid (canoid plus pinniped) carnivores. There is

Vincent M. Sarich



Speciation and phylogeography of giant petrels Macronectes  

Microsoft Academic Search

We examine global phylogeography of the two forms of giant petrel Macronectes spp. Although previously considered to be a single taxon, and despite debate over the status of some populations and the existence of minimal genetic data (one mitochondrial cytochrome b sequence per form), the current consensus based on morphology is that there are two species, Northern Giant Petrel M.

N. M. S. M. Techow; C. O’Ryan; R. A. Phillips; R. Gales; M. Marin; D. Patterson-Fraser; F. Quintana; M. S. Ritz; D. R. Thompson; R. M. Wanless; H. Weimerskirch; P. G. Ryan



Lithium Rich Red Giant Branch Stars  

Microsoft Academic Search

Lithium rich K giant stars are found at the luminosity bump of the first ascending red giant branch. The discovery of these stars has given a recent impulse to advances in the theory of stellar evolution. Important connections appeared between thermonuclear processes, rapid mixing, surface activity, rotation and mass loss episodes. How could such lithium surface enrichment be produced? Two

R. de La Reza



Effects of a Giant Impact on Uranus.  

National Technical Information Service (NTIS)

The effects of a giant impact on Uranus with respect to the axis tilt of Uranus and its satellites are discussed. The simulations of possible giant impacts were carried out using Cray supercomputers. The technique used is called smooth particle hydrodynam...

W. L. Slattery W. Benz A. G. W. Cameron



Giant magnetoresistance in spin-valve multilayers  

Microsoft Academic Search

A comprehensive review of giant magnetoresistance in spin-valve sandwiches and multilayers is presented, highlighting the experimental and theoretical results which are of particular interest for the development of applications of these systems, especially in magnetic recording technology. The main points discussed include the physical origin of the giant magnetoresistance, the influence of the thicknesses of the magnetic and nonmagnetic layers,

B. Dieny



Core formation in giant gaseous protoplanets  

Microsoft Academic Search

Sedimentation rates of silicate grains in gas giant protoplanets formed by disk instability are calculated for protoplanetary masses between 1 MSaturn to 10 MJupiter. Giant protoplanets with masses of 5 MJupiter or larger are found to be too hot for grain sedimentation to form a silicate core. Smaller protoplanets are cold enough to allow grain settling and core formation. Grain

Ravit Helled; Gerald Schubert



Giant sigmoid colonic diverticulitis: case report  

Microsoft Academic Search

Giant colonic diverticulum is a rare condition, and the usual site is the sigmoid colon. In this report, magnetic resonance imaging was performed in a patient with lower abdominal pain. The modality was useful for the evaluation of giant sigmoid colonic diverticulitis and the differential diagnosis.

S. Sugihara; S. Fujii; T. Kinoshita; T. Ogawa



Infrared continuum radiation from red giants  

Microsoft Academic Search

An analytical model is presented for the IR continuum radiation from red giant stars undergoing or recently having undergone rapid mass loss. The expanding circumstellar envelopes are expected to absorb most photospheric emissions, thereby rendering the red giants, e.g., Mira variables and OH\\/IR stars, undetectable at optical wavelengths. The model quantifies the radiative equilibrium between a dust grain and the

William K. Rose



Vesicocutaneous fistula caused by giant vesical calculus.  


Vesicocutaneous fistula is an extremely rare complication of vesical calculus.To our knowledge only three cases have been reported in the World literature. Because of its rarity, here we report a case of vesicocutaneous fistula caused by giant vesical calculus. This is probably the fourth case of vesicocutaneous fistula caused by giant vesical calculus. PMID:22468068

Deshmukh, Santoshkumar Nagnath; Maske, Audumbar N; Deshpande, Akshay P; Shende, Shweta P



[Giant uterine leiomyoma causing acute symptoms].  


The case history of a 71-year-old woman with acute dyspnoea caused by a giant leiomyoma and severe acute anemia due to intratumoral hemorrhage is presented. Urgent operation was performed, and a 13.5 kg pendular tumor was removed. The cornerstones of the differential diagnoses and therapy of giant abdominal tumors is discussed. PMID:23461980

Máté, Szabolcs; Szatmári, Erzsébet; Sipos, Norbert; Széll, János; Szánthó, András; Rigó, János



Endoscopic snare excision of “giant” colorectal polyps  

Microsoft Academic Search

Background: Endoscopic treatment of giant colorectal polyps remains controversial because of concerns regarding coexistent malignancy, incomplete resection, and safety. Methods: We reviewed the clinical course after removal of 176 benign-appearing large (>3 cm) colorectal polyps, which were removed by endoscopic snare resection in 170 patients. These were termed “giant” polyps. Sessile polyps (n = 129) were removed piecemeal and pedunculated

Kenneth F. Binmoeller; Sabine Bohnacker; Hans Seifert; Frank Thonke; Hemant Valdeyar; Nib Soehendra



Giant hydatid cysts of the lung  

Microsoft Academic Search

Background: Hydatid disease is a parasitic infection caused by Echinococcus granulosus, characterized by cystic lesions in the liver, lungs, and, rarely, in other parts of the body. The large cysts in the lung are a special clinical entity called giant hydatid cysts. Characteristics on presentation, operative techniques, and postoperative morbidity and mortality rates in 47 patients with 50 giant pulmonary

Semih Halezeroglu; Muharrem Celik; Aziz Uysal; Canan Senol; Murat Keles; Bulent Arman



Lessons from Giant-Scale Services  

Microsoft Academic Search

The past few years has seen an explosive growth in the size of infrastructur e services, particularly giant web sites and ISPs such as Yahoo!, AOL, Excite and others. Many new players are building these giant-scale services as well, including Microsoft, Disney, NBC, and CNN. In this paper, we look at the basic model followed by these services and examine

Eric A. Brewer



Giant Piloleiomyoma of the Forehead  

PubMed Central

Cutaneous piloleiomyomas are benign smooth muscle tumors arising from the arrector pili muscles. Piloleiomyomas appear as firm dermal papules of skin color or with a reddish to brown surface, and are commonly located on the extremities. Histologically, these lesions are composed of interlacing bundles of smooth muscle cells in the reticular dermis. Our case presented with an unusually large nodule on the forehead that was accompanied by intermittent pain. Histological analysis was compatible with piloleiomyoma and the lesion showed haphazardly arranged bundles of smooth muscle in the dermis. We describe herein an interesting case of a giant piloleiomyoma occurring on the forehead.

Kim, Gun-Wook; Park, Hyun-Je; Kim, Hoon-Soo; Kim, Su-Han; Ko, Hyun-Chang; Kim, Byung-Soo



The Traces of Advertising Giants  

NSDL National Science Digital Library

The Traces of Advertising Giants is an adverting history resource developed by graduate students at the University of Texas at Austin, Department of Advertising. The personal stories and professional profiles of infamous American advertisers are given, as well as hyperlinks to related topics and bibliographies for further research. Each decade in the twentieth and twenty-first centuries is covered through the present, and a few nineteenth century entries exist. Students will also benefit from the variety of web design techniques employed by UT authors, as well as the descriptions of historical tricks-of-the-trade.



Giant anterior mediastinal parathyroid adenoma.  


A 57-year-old woman with type 2 diabetes was admitted to our hospital presenting with generalized bone pains, hypercalcemia, and elevated parathyroid hormone level. Enhanced CT scan demonstrated a large soft tissue mass in the right anterior mediastinum. Tc-MIBI scintigraphy revealed the focal accumulation of radiotracer uptake in the anterior mediastinum. Tc-MIBI SPECT/CT imaging also corroborated the same finding. The patient underwent surgery to have a giant ectopic parathyroid adenoma (7 × 4.5 × 1.5 cm) removed. The patient has been observed for 2 years, with normal parathyroid hormone and calcium levels. PMID:22889780

Li, Lianxi; Chen, Libo; Yang, Yi; Han, Junfeng; Wu, Songhua; Bao, Yuqian; Jia, Weiping



Sodium in weak G-band giants  

NASA Astrophysics Data System (ADS)

Sodium abundances have been determined for eight weak G-band giants whose atmospheres are greatly enriched with products of the CN-cycling H-burning reactions. Systematic errors are minimized by comparing the weak G-band giants to a sample of similar but normal giants. If, further, Ca is selected as a reference element, model atmosphere-related errors should largely be removed. For the weak-G-band stars (Na/Ca) = 0.16 +/- 0.01, which is just possibly greater than the result (Na/Ca) = 0.10 /- 0.03 from the normal giants. This result demonstrates that the atmospheres of the weak G-band giants are not seriously contaminated with products of ON cycling.

Drake, Jeremy J.; Lambert, David L.



Esophageal hemangioma successfully treated by fulguration using potassium titanyl phosphate/yttrium aluminum garnet (KTP/YAG) laser: a case report.  


Esophageal hemangioma is an extremely rare tumor. We report a case of a 39-year-old man who was found to have an hemangioma which extended from the hypopharynx to the upper thoracic esophagus revealed by endoscopic examination. Computed tomography (CT) images, magnetic resonance imaging (MRI) and angiography were useful in the diagnosis. He was successfully treated by fulguration using potassium titanyl phosphate/yttrium aluminum garnet (KTP/YAG laser) four times and no recurrence has been seen. This patient has since been followed up carefully and additional fulguration will be performed if necessary. KTP/YAG laser is useful for the treatment of a large hemangioma as a less invasive method. PMID:14601909

Shigemitsu, K; Naomoto, Y; Yamatsuji, T; Ono, K; Aoki, H; Haisa, M; Tanaka, N



Feline hepatic disease.  


Species differences in anatomy, physiology, and biochemistry lead to many dissimilarities between the canine and feline liver. Major differences exist in the interpretation of liver function tests, the significance of biochemical jaundice, the consequences of anorexia, and the efficiency of hepatic metabolic systems. Biochemical alterations in total bilirubin, ALT, and SAP may indicate the presence of disease in the feline liver. It is, however, impossible to make accurate diagnoses without liver biopsy. A liver biopsy can provide a diagnosis and prognosis and can guide the therapeutic plan. The feline hepatic diseases most frequently seen in our hospital are hepatic lipidosis, cholangiohepatitis complex, toxic hepatopathy, and hepatic neoplasia. Less common diseases of the feline liver include extrahepatic biliary obstruction, portacaval vascular anomalies, hepatic parasites, hepatic cysts, and diaphragmatic hernia. Systemic diseases that can effect the liver of cats are feline infectious peritonitis, multicentric lymphosarcoma, myeloproliferative diseases, hemolytic anemia, infectious panleukopenia, and systemic fungal infections. PMID:6393553

Zawie, D A; Garvey, M S



Hepatitis B Frequently Asked Questions  


... Hepatitis B were infected at birth or during early childhood. How is Hepatitis B spread? Hepatitis B is ... it. However, some people, especially those infected during early childhood, remain infected for life because they never clear ...


Hepatite E Hepatitis E  

Microsoft Academic Search

Hepatitis E virus (HEV) is the second most frequent hepatotropic virus transmitted via fecal-oral route, following closely behind hepatitis A virus. The great epidemics of hepatitis described during the 50s and 60s, in India, were caused by this virus. Epidemic bursts have also been described in Central Africa, Latin America, Middle East and in the independent Republics of the ex-Soviet

Raymundo Paraná; Maria Isabel Schinoni


Hepatitis E infection  

Microsoft Academic Search

Hepatitis E — formerly called ‘enterically transmitted non-A non-B hepatitis’ — is transmitted by the faecal-oral route. The\\u000a Hepatitis E Virus (HEV) is a positive-sense single-stranded RNA virus and has great similarities to the caliciviruses. Virus\\u000a replication appears to be limited to the hepatocyte. The disease is especially endemic and\\/or epidemic on the Indian sub-continent.\\u000a Epidemics are mostly waterborne infections.

Axel Schmidt; Manfred H. Wolff


Propranolol treatment of infantile hemangiomas: anticipatory guidance for parents and caretakers.  


Infantile hemangiomas (IH) are benign tumors of endothelial-like cells. Occurring in 4.5% of children, they are the most common tumor of childhood. The great majority of patients with IH will not need treatment, but 10% require systemic treatment. Many treatments have been described for the treatment of IH, but the Food and Drug Administration has not approved any. Over the last decade, numerous reports of successful treatment of IH with propranolol have been published. Despite its widespread use, little is known regarding the proper dosing, safety monitoring, and during of treatment or long-term outcomes for propranolol treatment of IH. Given its potential side effects, detailed education regarding proper administration of the medication as well as warning signs to watch for is necessary for parents and caretakers. Herein, we provide a parental handout that practitioners can individually tailor for use in their clinics when educating parents and caretakers about the use of propranolol for IH. Updates will also need to be made as more is learned regarding the optimal dosing and safety monitoring when using propranolol for this indication. PMID:23316721

Martin, Kari; Blei, Francine; Bleib, Francine; Chamlin, Sarah L; Chiu, Yvonne E; Frieden, Ilona J; Frommelt, Peter C; Garzon, Maria C; Kwon, Eun-Kyung M; MacLellan-Tobert, Susan; Mancini, Anthony J; Seefeldt, Marcia; Sidbury, Robert; Siegel, Dawn H; Drolet, Beth A; Boucek, Robert J


Epithelioid hemangioma (angiolymphoid hyperplasia with eosinophilia) of the orbit: a case report  

PubMed Central

Background Angiolymphoid hyperplasia with eosinophilia (ALHE) and Kimura's Disease (KD) share many clinical and histopathological features. Although they were once considered different stages of the same disease, they are now known to represent separate entities. Recently, ALHE is being called epithelioid hemangioma (EH), a term that better describes the possible neoplastic nature of the entity. Case Presentation An eighteen year-old Asian female presented with a three-month history of fluctuating swelling and ptosis of the left upper eyelid. Computed tomography disclosed a distinct homogeneous lesion in the left superior orbit, molding to the globe and other orbital structures. At histopathological evaluation the lesion was composed of numerous blood vessels lined by plump endothelial cells with oval nuclei protruding into the lumen. Surrounding the vessels, there was a chronic inflammatory infiltrate with a large proportion of eosinophils. Based on clinical and histopathological findings, the diagnosis of EH was made. Conclusion Although exams like blood count, urinalysis and whole body scans can assist in the differential diagnosis, EH can be diagnosed and differentiated from KD on histopathological grounds. The presence of vascular hyperplasia with plump endothelial cells protruding into the lumen is the most important discriminator in establishing the diagnosis of EH. Such distinction is crucial for the patient because EH is not associated with any of the systemic manifestations present in KD.

Fernandes, Bruno F; Al-Mujaini, Abdullah; Petrogiannis-Haliotis, Tina; Al-Kandari, Abdullah; Arthurs, Bryan; Burnier, Miguel N



Radiotherapy for Symptomatic Vertebral Hemangiomas: Results of a Multicenter Study and Literature Review  

SciTech Connect

Purpose: The current study analyzes the potential role of radiotherapy (RT) in symptomatic vertebral hemangioma (SVH). Methods and Materials: Seven cooperating German institutions collected clinical information, treatment plans, and outcome data for all patients with SVH referred for local RT. Results: From 1969 to 2008, a total of 84 patients with 96 symptomatic lesions were irradiated for SVH. The primary indication for radiotherapy was pain (97.6%), and 28.6% of patients had additional neurological symptoms. RT was performed at a median total dose of 34 Gy, with a median single dose of 2.0 Gy. After receiving a median follow-up of 68 months, the overall patient response rate was 90.5%. Complete symptom remission occurred in 61.9% of patients, 28.6% of patients had partial pain relief, and 9.5% of patients had no pain relief. In 26.2% of patients, radiological signs of reossification were observed in long-term follow-up but not significantly correlated with pain relief. Most importantly, total doses of >=34 Gy resulted in significantly greater symptomatic relief and control rate than total doses of <34 Gy. Conclusions: This study consists of the largest database of cases reported so far using RT for SVH. RT is easy, safe, and effective for pain relief treatment for SVH. Total doses of at least 34 Gy give the best symptomatic response.

Heyd, Reinhard [Department of Radiotherapy, Offenbach Hospital, Offenbach (Germany); Seegenschmiedt, M. Heinrich [Department of Radiation Oncology, Alfried Krupp Hospital, Essen (Germany); Rades, Dirk [Department of Radiation Oncology, University Hospital Eppendorf, Hamburg (Germany); Winkler, Cornelia [Department of Radiotherapy, Carl Gustav Carus University Hospital, Dresden (Germany); Eich, Hans T. [Department of Radiotherapy, University Hospital, Cologne (Germany); Bruns, Frank [Department of Radiotherapy and Special Oncology, University Hospital, Hannover (Germany); Gosheger, Georg [Department of General and Surgical Orthopedics, University Hospital, Muenster (Germany); Willich, Normann [Department of Radiation Oncology, University Hospital, Muenster (Germany); Micke, Oliver, E-mail: omicke@benign-news.d [Department of Radiation Oncology, University Hospital, Muenster (Germany); Department of Radiotherapy and Radiation Oncology, Franziskus Hospital, Bielefeld (Germany)



Study on computer-aided diagnosis of hepatic MR imaging and mammography  

SciTech Connect

It is well known that the liver is an organ easily attacked by diseases. The purpose of this study is to develop a computer-aided diagnosis (CAD) scheme for helping radiologists to differentiate hepatic diseases more efficiently. Our software named LIVERANN integrated the magnetic resonance (MR) imaging findings with different pulse sequences to classify the five categories of hepatic diseases by using the artificial neural network (ANN) method. The intensity and homogeneity within the region of interest (ROI) delineated by a radiologist were automatically calculated to obtain numerical data by the program for input signals to the ANN. Outputs were the five pathological categories of hepatic diseases (hepatic cyst, hepatocellular carcinoma, dysplasia in cirrhosis, cavernous hemangioma, and metastasis). The experiment demonstrated a testing accuracy of 93% from 80 patients. In order to differentiate the cirrhosis from normal liver, the volume ratio of left to whole (LTW) was proposed to quantify the degree of cirrhosis by three-dimensional (3D) volume analysis. The liver region was firstly extracted from computed tomography (CT) or MR slices based on edge detection algorithms, and then separated into left lobe and right lobe by the hepatic umbilical fissure. The volume ratio of these two parts showed that the LTW ratio in the liver was significantly improved in the differentiation performance, with (25.6%{+-}4.3%) in cirrhosis versus the normal liver (16.4%{+-}5.4%). In addition, the application of the ANN method for detecting clustered microcalcifications in masses on mammograms was described here as well. A new structural ANN, so-called a shift-invariant artificial neural network (SIANN), was integrated with our triple-ring filter (TRF) method in our CAD system. As the result, the sensitivity of detecting clusters was improved from 90% by our previous TRF method to 95% by using both SIANN and TRF.

Zhang Xuejun [Electronics and Information Systems Engineering Division, Graduate School of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193 (Japan)




SciTech Connect

Recent surveys have revealed a lack of close-in planets around evolved stars more massive than 1.2 M{sub sun}. Such planets are common around solar-mass stars. We have calculated the orbital evolution of planets around stars with a range of initial masses, and have shown how planetary orbits are affected by the evolution of the stars all the way to the tip of the red giant branch. We find that tidal interaction can lead to the engulfment of close-in planets by evolved stars. The engulfment is more efficient for more-massive planets and less-massive stars. These results may explain the observed semimajor axis distribution of planets around evolved stars with masses larger than 1.5 M{sub sun}. Our results also suggest that massive planets may form more efficiently around intermediate-mass stars.

Villaver, Eva [Universidad Autonoma de Madrid, Departamento de fisica Teorica C-XI, 28049 Madrid (Spain); Livio, Mario, E-mail: eva.villaver@uam.e, E-mail: mlivio@stsci.ed [Space Telescope Science Institute, 3700 San Martin Drive, Baltimore, MD 21218 (United States)



Peripheral giant cell granuloma: a case report.  


The peripheral giant cell granuloma is a reactive lesion of the soft tissue of the oral cavity. Clinical appearance ranges from normal tissue coloration to dark red or purplish. These are elevated lesions generally 5-15 mm in diameter. Etiology is considered to be chronic irritation. To decrease the risk of clinical recurrence, treatment is complete excision to include the underlying periosteum. Histologic features of the peripheral giant cell granuloma include multinucleated giant cells with a stroma that may contain osteoblasts, myofibroblasts, macrophages, and Langerhans cells. A case report is presented. PMID:12004669

Breault, L G; Fowler, E B; Wolfgang, M J; Lewis, D M


Inhibition of matrix metalloproteinases by over-expression of tissue inhibitor of metalloproteinase-2 inhibits the growth of experimental hemangiomas.  


Inhibitors of proteases prevent tumor-associated matrix degradation, affecting tumor growth, angiogenesis and metastasis. Our study was designed to investigate the effect of inhibition of matrix metalloproteinases (MMPs) on the growth of experimental hemangiomas, using the model of murine endothelioma eEnd.1 cells. In nude mice, these cells generate hemangiomas, consisting mostly of host-recruited endothelial cells, whose growth requires the activity of MMPs. In vitro, eEnd.1 cells produce factors that recruit endothelial cells and stimulate them to release MMPs. Over-expression of TIMP-2, following retrovirus-mediated gene transfer, decreased tumor growth in vivo. The infected clone CR1, which produces high levels of TIMP-2 (as assessed by Northern blot, ELISA and reverse zymography), formed slow-growing tumors that did not grow beyond 0.4 g, while clone 1H, which produces little TIMP-2, grew not dissimilarly to mock-infected cells and parental e.End.1 cells. Histologically, control tumors presented the features of cavernous hemangiomas, while CR1 tumors had a more solid pattern, showing foci of apoptotic cells. In vitro, TIMP-2 over-expression had no autocrine anti-proliferative effect on endothelioma cells but reduced their ability to recruit endothelial cells. CR1 cells lacked the capacity of mock-infected or parental eEnd.1 cells to stimulate endothelial cell motility and invasiveness. Antibodies against TIMP-2 restored the ability of CR1 to induce endothelial cell invasion. We conclude that, in this model, genetic increase of TIMP-2 inhibits tumor growth, apparently by affecting the recruitment and organization of host endothelial cells by the transformed cells. PMID:11146452

Vergani, V; Garofalo, A; Bani, M R; Borsotti, P; Parker, M P; Drudis, T; Mazzarol, G; Viale, G; Giavazzi, R; Stetler-Stevenson, W G; Taraboletti, G



Giant magnetoresistance in nanogranular magnets.  

SciTech Connect

We study the giant magnetoresistance of nanogranular magnets in the presence of an external magnetic field and finite temperature. We show that the magnetization of arrays of nanogranular magnets has hysteretic behavior at low temperatures leading to a double peak in the magnetoresistance which coalesces at high temperatures into a single peak. We numerically calculate the magnetization of magnetic domains and the motion of domain walls in this system using a combined mean-field approach and a model for an elastic membrane moving in a random medium, respectively. From the obtained results, we calculate the electric resistivity as a function of magnetic field and temperature. Our findings show excellent agreement with various experimental data.

Glatz, A.; Beloborodov, I. S.; Vinokur, V. M.; Materials Science Division; Univ. of Chicago



[Unusual presentation of giant thymolipoma].  


Thymolipoma is a rare thymic tumor; His frequency is estimated at 2 at 9% of all thymic tumors. His diagnosis usually easy, can be difficult with an unusual radio clinic pattern, but actually get benefice from progress in radiologic investigations especially MRI. We reported a case of a 36-year old woman, admitted for a left pleuro-pneumopathy investigation. Evolution, after antibiotic treatment and pleural effusion draining, was well. However, patient developed systolic aortic murmur and a chest-X-ray cardiomegaly supposing cardiologic dysfunction. But the normality of cardiac sonography, the ascension of diaphragma and non-specific thoracic sonographic pattern, guided to thoracic MRI. This exploration demonstrated a giant thymolipoma, which was confirmed by the histologic examination of a resected mass. PMID:12708194

Fenniche, Soraya; Maalej, Sonia; Hassene, Hela; Hantous, Saoussen; Belhabib, Dalenda; Bakkari, Sonia; el Mezni, Faouzi; Horchani, Habiba; Megdiche Mohamed, Lamine



Giant mediastinal thymolipoma simulating cardiomegaly.  


Thymolipomas are rare anterior mediastinal tumors composed of mature adipose tissue and benign thymic tissue and they may rarely simulate cardiomegaly on chest radiograph. We report an adult male who presented with progressive dyspnea of 2 months' duration. Clinical examination was unremarkable. Chest radiograph showed enlarged cardiac silhouette. Computed tomography of chest revealed a giant anterior mediastinal noncontrast enhancing mass partially wrapping around the heart. A needle biopsy obtained lymphomatous material that was diagnosed as thymolipoma. The tumor was successfully removed en bloc through a median sternotomy. Histopathological examination confirmed thymolipoma. We emphasize the importance of considering mediastinal tumors as a differential diagnosis in patients with progressive dyspnea without any obvious cause and chest radiograph showing enlarged cardiac silhouette. PMID:19782275

Mohan Rao, Prasanna Simha; Moorthy, Nagaraja; Shankarappa, Ravindranath Khandenahalli; Bhat, Prabhavathi; Nanjappa, Manjunath Cholenahalli



Standard fractionation low-dose proton radiotherapy for diffuse choroidal hemangiomas in pediatric Sturge-Weber syndrome.  


Sturge-Weber syndrome is a nonhereditary congenital neurocutaneous syndrome characterized by leptomeningeal angiomatosis, facial nevus flammeus, and diffuse choroidal hemangioma, which when complicated by total retinal detachment, portend a poor prognosis. Management is often limited to salvage external beam irradiation. We present a modified proton therapy technique for young children with total bullous retinal detachments that uses standard fractionation low-dose proton radiotherapy to decrease the risk of radiation complications. Treatment techniques for young children who cannot cooperate with conventional radiation protocols are also described. PMID:23618630

Yonekawa, Yoshihiro; MacDonald, Shannon M; Shildkrot, Yevgeniy; Mukai, Shizuo



Diffuse cavernous hemangioma of the uterus in a pregnant woman: report of a rare case and review of literature  

Microsoft Academic Search

Introduction  Diffuse cavernous hemangioma of the uterus in pregnant woman is an extremely rare condition. A total of eight cases have been\\u000a described in the literature till date. The antenatal diagnosis as well as management requires considerable skill. Although\\u000a it is a benign condition but it can have serious consequences for the mother as well as the baby.\\u000a \\u000a \\u000a \\u000a Methods and Materials  Here

Renu K. Virk; Jiang Zhong; Di Lu



Giant vesicles as cell models.  


Tremendous progress has been made in recent years in understanding the working of the living cell, including its micro-anatomy, signalling networks, and regulation of genes. However, an understanding of cellular phenomena using fundamental laws starting from first principles is still very far away. Part of the reason is that a cell is an active and exquisitely complex system where every part is linked to the other. Thus, it is difficult or even impossible to design experiments that selectively and exclusively probe a chosen aspect of the cell. Various kinds of idealised systems and cell models have been used to circumvent this problem. An important example is a giant unilamellar vesicle (GUV, also called giant liposome), which provides a cell-sized confined volume to study biochemical reactions as well as self-assembly processes that occur on the membrane. The GUV membrane can be designed suitably to present selected, correctly-oriented cell-membrane proteins, whose mobility is confined to two dimensions. Here, we present recent advances in GUV design and the use of GUVs as cell models that enable quantitative testing leading to insight into the working of real cells. We briefly recapitulate important classical concepts in membrane biophysics emphasising the advantages and limitations of GUVs. We then present results obtained over the last decades using GUVs, choosing the formation of membrane domains and cell adhesion as examples for in-depth treatment. Insight into cell adhesion obtained using micro-interferometry is treated in detail. We conclude by summarising the open questions and possible future directions. PMID:22829218

Fenz, Susanne F; Sengupta, Kheya



Morphologic Studies of Hepatitis.  

National Technical Information Service (NTIS)

Particles were found in cases of chronic hepatitis in hepatocellular nuclei, and these were identified as Australia antigen (HB Ag) by its ability to combine with ferritin labelled HB antibody. The relation of HB Ag to hepatitis has been postulated to be ...

F. Schaffner



[Viral hepatitis during pregnancy].  


Viral hepatitis is one of the most common liver diseases appearing during pregnancy. Prevention against hepatotropic viruses is restricted due to lack of vaccines being effective in induction of efficient immunization in the majority of these microorganisms. In general, there is no possibility of active immunization against hepatotropic viruses except type A and B viral hepatitis. An issue of viral hepatitis in pregnancy as an aspect of potential risk factor connected with infection of pregnant women and a fetus has been described in this paper. Furthermore, the most important topics in the field of the epidemiology, prophylaxis and possible treatment options of viral hepatitis A, B, C, D, E and G have been discussed. The newest reports of pregnant women lamivudine therapy as a preventive treatment against vertical transmission during delivery have been reviewed. Rarly diagnosed viral hepatitis caused by herpes simplex virus, cytomegalovirus, Epstein-Barr virus and adenoviruses have been characterized as well. PMID:17219815

Gutkowski, Krzysztof; Gutkowska, Dorota; Lepiech, Jacek



Hepatitis A in Children  

Microsoft Academic Search

\\u000a \\u000a \\u000a \\u000a \\u000a \\u000a • \\u000a \\u000a \\u000a \\u000a Hepatitis A virus is the most common viral hepatitis globally.\\u000a \\u000a \\u000a \\u000a \\u000a • \\u000a \\u000a \\u000a \\u000a Hepatitis A virus is a serious public health concern, and causes significant morbidity and mortality.\\u000a \\u000a \\u000a \\u000a \\u000a • \\u000a \\u000a \\u000a \\u000a The changing epidemiological features of hepatitis A are associated with the inception of vaccine programs.\\u000a \\u000a \\u000a \\u000a \\u000a • \\u000a \\u000a \\u000a \\u000a Hepatitis A infection has numerous clinical presentations.

Michelle Rook; Philip Rosenthal


Giant salivary calculi of the submandibular gland  

PubMed Central

Sialolithasis is the most common salivary gland disease. A case of an unusually large sialolith arising in the submandibular gland is presented, along with a review of the management of giant salivary gland calculi.

Fowell, C; MacBean, A



Polymyalgia Rheumatica and Giant Cell Arteritis  


... reasons for the patient's symptoms. The most typical laboratory finding in people with polymyalgia rheumatica is an ... Vasculitis Clinical Research Consortium are collecting clinical and laboratory information from patients with giant cell arteritis to ...


"GIANT" Steps to Create Online Orientations  

ERIC Educational Resources Information Center

Online orientation is provided due to the flexibility of online learning. The online orientation consists of the GIANT steps which stands for Get support, Identify your curriculum, Assemble your program, Navigate students through the pilot project and Test students.

Bacon, Pamela



Comparison of Permian basin giant oil fields with giant oil fields of other U. S. productive areas  

SciTech Connect

Covering over 40 million ac, the Permian basin is the fourth largest of the 28 productive areas containing giant fields. The 56 giant fields in the basin compare with the total of 264 giant oil fields in 27 other productive areas. Cumulative production figures of 18 billion bbl from the giant fields in the Permian basin are the largest cumulative production figures from giant fields in any of the productive areas. An estimated 1.9 billion bbl of remaining reserves in giant fields rank the basin third among these areas and the 19.9 billion bbl total reserves in giant fields in the basin are the largest total reserves in giant fields in any of the productive areas. The 1990 production figures from giant fields place the basin second in production among areas with giant fields. However, converting these figures to by-basin averages for the giant fields places the Permian basin 12th in field size among the areas with giant fields. Based on average reserves per well, the basin ranks 18th. Average 1990 production per giant field place the basin seventh and the average 1990 production per well in giant fields place the Permian basin 14th among the areas with giant fields.

Haeberle, F.R. (Consultant Geologist, Dallas, TX (United States))



Entry Probe Missions to the Giant Planets  

NASA Astrophysics Data System (ADS)

The primary motivation for in situ probe missions to the outer planets derives from the need to constrain models of solar system formation and the origin and evolution of atmospheres, to provide a basis for comparative studies of the gas and ice giants, and to provide a valuable link to extrasolar planetary systems. As time capsules of the solar system, the gas and ice giants offer a laboratory to better understand the atmospheric chemistries, dynamics, and interiors of all the planets, including Earth; and it is within the atmospheres and interiors of the giant planets that material diagnostic of the epoch of formation can be found, providing clues to the local chemical and physical conditions existing at the time and location at which each planet formed. Measurements of current conditions and processes in those atmospheres inform us about their evolution since formation and into the future, providing information about our solar system’s evolution, and potentially establishing a framework for recognizing extrasolar giant planets in different stages of their evolution. Detailed explorations and comparative studies of the gas and ice giant planets will provide a foundation for understanding the integrated dynamic, physical, and chemical origins, formation, and evolution of the solar system. To allow reliable conclusions from comparative studies of gas giants Jupiter and Saturn, an entry probe mission to Saturn is needed to complement the Galileo Probe measurements at Jupiter. These measurements provide the basis for a significantly better understanding of gas giant formation in the context of solar system formation. A probe mission to either Uranus or Neptune will be needed for comparative studies of the gas giants and the ice giants, adding knowledge of ice giant origins and thus making further inroads in our understanding of solar system formation. Recognizing Jupiter’s spatial variability and the need to understand its implications for global composition, returning to Jupiter with a follow-on probe mission, possibly with technological advances allowing a multiple-probe mission, would make use of data from the Juno mission to guide entry location and measurement suite selection. This poster summarizes a white paper prepared for the Space Studies Board’s 2013-2022 Planetary Science Decadal Survey. It discusses specific measurements to be made by planetary probes at the giant planets, rationales and priorities for those measurements, and locations within the destination atmospheres where the measurements are best made.

Spilker, T. R.; Atkinson, D. H.; Atreya, S. K.; Colaprete, A.; Cuzzi, J. N.; Spilker, L. J.; Coustenis, A.; Venkatapathy, E.; Reh, K.; Frampton, R.



AGB (asymptotic giant branch): Star evolution  

SciTech Connect

Asymptotic giant branch stars are red supergiant stars of low-to-intermediate mass. This class of stars is of particular interest because many of these stars can have nuclear processed material brought up repeatedly from the deep interior to the surface where it can be observed. A review of recent theoretical and observational work on stars undergoing the asymptotic giant branch phase is presented. 41 refs.

Becker, S.A.



Laughing headache with giant pacchionian granulations.  


Laughing is recognized as a provoking factor for headache, certainly underestimated among the general population and few cases have been published to date. We report a single case of severe headache, provoked almost exclusively by outbursts of laughing, where venous magnetic resonance imaging revealed the presence of giant Pacchioni granulations in both right and transverse sinuses. Reviewing published cases of laughing headache, we discuss possible mechanisms of pain and the role of giant Pacchionian granulations. PMID:23425026

Giraud, Pierric; Segal, Olivier; Chauvet, Sylvie



Human macrophage hybrid forming spontaneous giant cells  

Microsoft Academic Search

Summary  Thymidine kinase-deficient clones of the human monocyte\\/ macrophage cell line U-937 were established and used for fusion experiments\\u000a with separated normal human blood monocytes. A hybrid (H 29) was generated during HAT-selection procedure, about 50% of which\\u000a formed spontaneous giant cells, as shown by morphological, immunocytochemical, and chromosomal analyses. It is concluded that\\u000a giant cells originate from monocytes and display

Mohammad R. Parwaresch; Hans Kreipe; Heinz J. Radzun



Dynamic models applied to giant barnacle culture  

Microsoft Academic Search

In this study, a dynamic model is applied to giant barnacle (Austromegabalanus psittacus) spat collection from artificial substrates located in the wild. Semi-industrial culture of the giant barnacle, A. psittacus “picoroco” in southern Chile is an interesting option for aquaculture diversification. The model establishes relationships\\u000a between variables and carries out simulations to determine their effects on spat provision. The dynamic

Lorenzo I. Andrade; Daniel A. López; Boris A. López


The Many Faces of Red Giants  

NASA Astrophysics Data System (ADS)

We summarize some of the infrared work done on red giants in Vienna during the last years. Recent results presented in the poster concern the atmospheric dynamics, elemental abundances and dust mineralogy of AGB-stars in galactic and extragalactic globular clusters using ground based IR-spectrometers and the Spitzer-IRS. We also discuss the atmospheric structure of nearby carbon-rich giants investigated with MIDI at the VLTI.

Hron, J.; Aringer, B.; Kerschbaum, F.; Lebzelter, T.; Nowotny, W.; Posch, T.; Lederer, M.; Richter, H.; Galsterer, W.; Höfner, S.; Gautschy-Loidl, R.; Verhoelst, T.


Giant lipomas of the upper extremity  

PubMed Central

Lipomas are slow-growing soft tissue tumours that rarely reach a size larger than 2 cm. Lesions larger than 5 cm, so-called giant lipomas, can occur anywhere in the body but are seldom found in the upper extremities. The authors present their experiences with eight patients having giant lipomas of the upper extremity. In addition, a review of the literature, and a discussion of the appropriate evaluation and management are included.

Allen, Brian; Rader, Christine; Babigian, Alan



Diagnostics of Deep Structure in Giant Planets  

Microsoft Academic Search

High-resolution, high-precision maps of surface shape and gravity are available for most of the terrestrial planets, but such data are still lacking for the giant planets because of the difficulty of executing low-periapse orbiter missions. With the approval of the Juno mission to Jupiter, a highly capable geodetic mission to a giant planet is now in prospect, and a Juno-like

W. B. Hubbard



Lithium Rich Red Giant Branch Stars  

Microsoft Academic Search

Lithium rich K giant stars are found at the luminosity bump of the first ascending red giant branch. The discovery of these\\u000a stars has given a recent impulse to advances in the theory of stellar evolution. Important connections appeared between thermonuclear\\u000a processes, rapid mixing, surface activity, rotation and mass loss episodes. How could such lithium surface enrichment be produced?\\u000a Two

R. de la Reza


Giant resonance splitting in deformed nuclei  

SciTech Connect

We describe the giant resonances as simple scaling solutions of a linearized Vlasov equation obtained from a time-dependent Hartree-Fock theory in phase space. For ellipsoidal deformed nuclei we get a splitting of the isoscalar giant quadrupole resonance proportional to the ground state charge quadrupole moment. The lower energy state ( parallel/ for prolate nuclei, perpendicular/ for oblate) always gets the larger electromagnetic strength.

Di Nardo, M.; Di Toro, M.; Giansiracusa, G.; Lombardo, U.; Russo, G.



Giant cell ependymoma: A case report  

Microsoft Academic Search

Ependymomas account for 3–9% of all neuroepithelial tumors. A peculiar variant of ependymoma known as “giant cell ependymoma” (“GCE”) is especially rarely reported, it may pose some difficulties for the diagnosing neuropathologist. Here we present a case of a giant cell ependymoma occuring in a 17-year-old patient with the history of 2-year recurrent headaches and a 1-month history of vision

Dariusz Adamek; Malgorzata Dec; Grazyna Sobol; Barbara Urbanowicz; Marian Jaworski



A giant planet around the massive giant star HD 13189  

NASA Astrophysics Data System (ADS)

Most extrasolar planet discoveries using radial velocity measurements have been for solar-like G-stars. In order to understand better the role stellar mass for the formation of planets we must learn more about the frequency of planetary companions around both high- and low-mass stars. Radial velocity searches for planets around high mass main-sequence stars are difficult due to the paucity of lines and often rapid rotation of these early-type stars. On the other hand, evolved stars that have moved off the main sequence offer us the possibility of searching for planets around higher mass stars by means of precise radial velocity measurements. Here we present radial velocity measurements for the star HD 13189 using measurements taken at the Thüringer Landessternwarte Tautenburg, the Harlan J. Smith Telescope at McDonald Observatory, and the Hobby-Eberly Telescope. We classify the spectral type of this star as K2 with luminosity class II. The radial velocity measurements show long-period variations with a period of 472 days and an amplitude of 173 m s-1. The Ca II S-index is consistent with an inactive star and this shows no variations with the radial velocity period. We also investigated possible changes in the line shapes by measuring spectral line bisectors. These show no variations with the radial velocity period. We interpret the 472-day period as being caused by a sub-stellar companion. Based on the estimated absolute magnitude and a comparison to evolutionary tracks we estimate the mass of the progenitor star between 2 and 7 M_? which results in a projected mass of the companion of m sin i = 8 20 M_J. HD 13189 may be the most massive star known to possess an extrasolar planet. This suggests that the formation of giant planets can also occur around early-type stars. HD 13189 also shows significant short term radial velocity variability on time scales of days that is most likely due to stellar oscillations. This behavior is typical for K giant stars.

Hatzes, A. P.; Guenther, E. W.; Endl, M.; Cochran, W. D.; Döllinger, M. P.; Bedalov, A.



Giant cell ependymoma: a case report.  


Ependymomas account for 3-9% of all neuroepithelial tumors. A peculiar variant of ependymoma known as "giant cell ependymoma" ("GCE") is especially rarely reported, it may pose some difficulties for the diagnosing neuropathologist. Here we present a case of a giant cell ependymoma occuring in a 17-year-old patient with the history of 2-year recurrent headaches and a 1-month history of vision impairment. CT scanning demonstrated a mass in the left occipital lobe, arising from the occipital horn of the lateral ventricle. Histological, immunohistochemical and electron microscopic findings were consistent with high-grade ependymoma. Especially striking was the presence of bizzare pleomorphic giant cells which predominated in the tumor tissue. As a result the diagnosis of GCE was established. This type of neoplasm necessitates, at least in theory, differentiation with anaplastic oligodendroglioma, clear cell ependymoma, pleomorphic xanthoastrocytoma, giant cell glioblastoma, and subependymal giant cell astrocytoma. To date giant cell ependymomas (GCEs) were reported in seven cases in the literature. To the best of our knowledge this is the 8th case in the literature. In spite of apparently "worrisome" histology GCE seems to be a neoplasm with a relatively good prognosis. PMID:18006220

Adamek, Dariusz; Dec, Malgorzata; Sobol, Grazyna; Urbanowicz, Barbara; Jaworski, Marian



Pulmonary sclerosing hemangioma presenting with dense spindle stroma cells: a potential diagnostic pitfall  

PubMed Central

Pulmonary sclerosing hemangioma (PSH) is an uncommon pulmonary tumor. Histologically, PSH typically consists of two types of cells, surface cuboidal cells and polygonal cells, four architectural patterns including papillary, sclerotic, solid, and hemorrhagic. Herein, we present a case of PSH in a 59-year-old Chinese female. The tumor was predominantly composed of solid area presenting with diffuse spindle cells rather than polygonal cells. Focally, classical papillary and sclerotic area could be seen. Immunohistochemical staining showed that the spindle cells were positive for TTF-1, EMA, Actin(SM) and Vimentin, and negative for cytokeratin, cytokeratin7, cytokeratin5/6, surfactant apoprotein A, surfactant apoprotein B, CD34, CD99, S-100, HMB45, Desmin, Synaptophysin, CD56, ALK and Calretinin. The immunophenotype of the dense spindle cells in this case was similar to that of the polygonal cells, and thus the spindle cells may be the variants of polygonal cells. Based on morphologic features and the immunohistochemical profile, the tumor was diagnosed as a PSH. The significance of spindle cells change is unclear for us. To our knowledge, this is the first reported case of PSH showing dense spindle cells in solid area. This case represents a potential diagnostic pitfall, as it may be misdiagnosed as a mesenchymal tumor such as inflammatory myofibroblastic tumor, synovial sarcoma, solitary fibrous tumor, leiomyoma, or even mesothelioma, especially if the specimen is limited or from fine- needle aspiration. Virtual slides The virtual slide(s) for this article can be found here:



Targetoid hemosiderotic hemangioma— a dynamic vascular tumor: Report of 3 cases with episodic and cyclic changes and comparison with solitary angiokeratomas  

Microsoft Academic Search

Background: Both targetoid hemosiderotic hemangiomas (THH) and solitary angiokeratomas (SAK) are acquired vascular malformations formed by superficial vascular ectasias possibly caused by trauma. Objective: We compare the clinicopathologic findings of THHs with those of SAKs and report the clinicopathologic findings of 3 singular cases of THH affected by cyclic or episodic morphologic changes. Methods: We performed a clinicopathologic study on

J. Andrew Carlson; Soume Daulat; Herbert P. Goodheart



Rapid formation of gas giants, ice giants and super-Earths  

Microsoft Academic Search

Giant planets might have been formed by either of the two basic mechanisms, top-down (disk instability) or bottom-up (core accretion). The latter mechanism is the most generally accepted mechanism and it begins with the collisional accumulation of solid cores that may then accrete sufficient gas to become gas giants. The former mechanism is more heretical and begins with the gravitational

A P Boss



Hepatic Steatosis in Chronic Hepatitis C: Risk factors and role in the development of hepatic fibrosis  

Microsoft Academic Search

3. To identify viral and non-viral risk factors for hepatic steatosis in patients with chronic hepatitis C. 4. To identify metabolic predictors of week 20 and sustained virologic response 5. To determine the effects of long-term interferon therapy on hepatic steatosis in patients with chronic hepatitis C. 6. To determine the effects of virologic clearance on insulin resistance in patients

Anna S. F. Lok; Zachary Goodman; Joel Greenson; James Everhart


Giant Cell Tumor Arising from Anterior Arc of the Rib  

PubMed Central

A primary giant cell tumor of the rib is very rare. The most common site of a giant cell tumor arising from the rib is the posterior arc. A giant cell tumor arising from the anterior arc of the rib is extremely rare. The treatment of a giant cell tumor of the rib is not well defined. Generally, a complete surgical resection is performed in a patient with a primary giant cell tumor of the rib. We report a case of a giant cell tumor arising from the anterior arc of the rib that was treated with a wide excision and chest wall reconstruction.

Heo, Woon; Min, Ho-Ki; Jun, Hee Jae; Hwang, Youn-Ho



How to improve a neural network for early detection of hepatic cancer.  


Radiologists perform differential diagnoses of hepatic (liver) masses using ultrasonography (US), computed tomography (CT), magnetic resonance imaging (MRI), and laboratory tests, but interpretation is often difficult. In our earlier research, a backpropagation neural network was designed to diagnose five classifications of hepatic masses: metastatic carcinoma, hepatoma, cavernous hemangioma, abscess, and cirrhosis. After being trained using ultrasonographic data and laboratory tests, the network classified hepatic masses correctly in 51 of 72 cases. That accuracy of 71% is higher than the 50% scored by the average radiology resident in training but lower than the 90% scored by the typical board-certified radiologist. What do we need to do to increase that accuracy and make the network friendly enough that radiologists will use it in their diagnoses? We have reviewed the literature, discussed alternatives and developed a plan to improve the diagnostic accuracy of the networks. That plan consists of: (i) get many more patient cases and more data variables, including MRI and CT data, so the network can be more highly trained. A shortage of enough patient cases to properly train the network is the key problem; (ii) use genetic algorithms and other techniques to preprocess the data; (iii) the network should have an optical interface to read images directly; and (iv) build a user-friendly interface using the C programming language on a 486 microcomputer. Continued research along the guidelines in this study should provide a sophisticated neural network for early detection of hepatic cancer that hopefully will exceed the diagnostic abilities of most radiologists. PMID:8168071

Maclin, P S; Dempsey, J



Young Solar System's Fifth Giant Planet?  

NASA Astrophysics Data System (ADS)

Studies of solar system formation suggest that the solar system's giant planets formed and migrated in the protoplanetary disk to reach the resonant orbits with all planets inside ~15 AU from the Sun. After the gas disk's dispersal, Uranus and Neptune were likely scattered by the gas giants, and approached their current orbits while dispersing the transplanetary disk of planetesimals, whose remains survived to this time in the region known as the Kuiper Belt. Here we performed N-body integrations of the scattering phase between giant planets in an attempt to determine which initial states are plausible. We found that the dynamical simulations starting with a resonant system of four giant planets have a low success rate in matching the present orbits of giant planets and various other constraints (e.g., survival of the terrestrial planets). The dynamical evolution is typically too violent, if Jupiter and Saturn start in the 3:2 resonance, and leads to final systems with fewer than four planets. Several initial states stand out in that they show a relatively large likelihood of success in matching the constraints. Some of the statistically best results were obtained when assuming that the solar system initially had five giant planets and one ice giant, with the mass comparable to that of Uranus and Neptune, and which was ejected to interstellar space by Jupiter. This possibility appears to be conceivable in view of the recent discovery of a large number of free-floating planets in interstellar space, which indicates that planet ejection should be common.

Nesvorný, David



Regression of giant bullous emphysema.  


Spontaneous resolution of bulla associated with infection or tumor is occasionally observed. However, resolution of progressively enlarging giant bullous emphysema (GBE) after medical therapy has not been reported. A 51-year-old man smoker with GBE on the right lung was referred to Samsung Medical Center for the consideration of bullectomy. A review of his medical records revealed that right-side bullous emphysema had been detected 4 years previously and it had progressively enlarged with a concomitant deterioration of lung function. Although he had a history of chronic asthma, he had never been treated on a regular basis. After combination therapy, including regular tiopropium, a salmeterol/flucatisone inhaler, a salbutamol inhaler as needed, and oral theophylline therapy, right side bulla showed marked regression. This regression of bulla was associated with an improved forced expiratory volume in one second and normalization of residual volume. This case serves as a reminder to clinicians that medical treatment for underlying diseases should precede surgical consideration in patients with GBE. PMID:20046002

Park, Hye Yun; Lim, Seong Yong; Park, Hye Kyeong; Park, So Young; Kim, Tae Sung; Suh, Gee Young



Giant electrocaloric effect around Tc.  


We use molecular dynamics with a first-principles-based shell model potential to study the electrocaloric effect (ECE) in lithium niobate, LiNbO(3), and find a giant electrocaloric effect along a line passing through the ferroelectric transition. With an applied electric field, a line of maximum ECE passes through the zero field ferroelectric transition, continuing along a Widom line at high temperatures with increasing fields, and along the instability that leads to homogeneous ferroelectric switching below T(c) with an applied field antiparallel to the spontaneous polarization. This line is defined as the minimum in the inverse capacitance under an applied electric field. We investigate the effects of pressure, temperature and an applied electric field on the ECE. The behavior we observe in LiNbO(3) should generally apply to ferroelectrics; we therefore suggest that the operating temperature for refrigeration and energy scavenging applications should be above the ferroelectric transition region to obtain a large electrocaloric response. The relationship between T(c), the Widom line, and homogeneous switching should be universal among ferroelectrics, relaxors, multiferroics, and the same behavior should be found under applied magnetic fields in ferromagnets. PMID:23215332

Rose, Maimon C; Cohen, R E



Giant Electrocaloric Effect Around Tc  

NASA Astrophysics Data System (ADS)

We use molecular dynamics with a first-principles-based shell model potential to study the electrocaloric effect (ECE) in lithium niobate, LiNbO3, and find a giant electrocaloric effect along a line passing through the ferroelectric transition. With an applied electric field, a line of maximum ECE passes through the zero field ferroelectric transition, continuing along a Widom line at high temperatures with increasing fields, and along the instability that leads to homogeneous ferroelectric switching below Tc with an applied field antiparallel to the spontaneous polarization. This line is defined as the minimum in the inverse capacitance under an applied electric field. We investigate the effects of pressure, temperature and an applied electric field on the ECE. The behavior we observe in LiNbO3 should generally apply to ferroelectrics; we therefore suggest that the operating temperature for refrigeration and energy scavenging applications should be above the ferroelectric transition region to obtain a large electrocaloric response. The relationship between Tc, the Widom line, and homogeneous switching should be universal among ferroelectrics, relaxors, multiferroics, and the same behavior should be found under applied magnetic fields in ferromagnets.

Rose, Maimon C.; Cohen, R. E.



Giant Orbitals Currents in Nanostructures  

NASA Astrophysics Data System (ADS)

The possibility and origin of giant orbital currents [1] in nanostructures is investigated by model calculations. We compare two models: (i) a model where electrons are confined to a ``racetrack'' around the dot and (ii) a tight-binding model where atomic spin-orbit coupling creates macroscopic currents at the periphery of the dots. The first model yields expressions very similar to Ref. 1, but the corresponding spin-orbit coupling [2] is negligibly small, because it strongly decreases with increasing orbital radius. Furthermore, the orbital moment rapidly collapses due to a redistribution of electron with wave vectors of opposite sense of rotation. In the second model, the relatively strong intra-atomic spin-orbit interaction yields orbital currents that add [3] between neighboring atoms and create a macroscopic current at the periphery of the dot. This current corresponds to a magnetic Berry phase and cannot dissipate, because the underlying atomic orbital moments are quantized. References: [1] A. Hernando, P. Crespo, and M. A. Garc'ia, Phys. Rev. Lett. 96, 057206 (2006). [2] R. Skomski, IEEE Trans. Magn. 32, 4794 (1996). [3] J. Zhang, R. Skomski, Y. F. Lu, and D. J. Sellmyer, Phys. Rev. B 75, 214417 (2007).

Skomski, Ralph; Sellmyer, D. J.



Therapy of viral hepatitis.  


Worldwide viral hepatitis is the most common cause of jaundice, chronic liver disease cirrhosis and hepatocellular carcinoma. While important advances have been made in prevention of viral hepatitis, therapy of this disease remains unsatisfactory. There are no specific therapies of proven benefit for acute hepatitis, although use of alpha-interferon during the acute phase of hepatitis C may result in a decrease in the rate of chronicity. For chronic viral hepatitis, alpha-interferon has been widely used, but is expensive, poorly tolerated and limited in effectiveness. New antiviral agents and use of combinations of antivirals are now being evaluated and promise to provide a therapy that is effective in the majority of patients. The currently recommended therapy of chronic hepatitis B is a 4- to 6-month course of alpha-interferon in doses of 5-10 million units three times a week; a regimen that results in sustained clearance of hepatitis B virus (HBV) DNA and hepatitis B e antigen (HBeAg) from serum in approximately one-third and a loss of hepatitis B surface antigen (HBsAg) in one-tenth of patients. Long-term follow-up of patients who respond to interferon treatment with clearance of HBeAg indicate that the majority ultimately clear HBsAg as well and have continued remission in the liver disease, although low levels of HBV DNA can commonly be detected in liver tissue. Better therapies of hepatitis B are needed. Recently, several oral 'second-generation' nucleoside analogues have been developed that have potent activity against HBV. The best studied is lamivudine (3-thiacytidine) which results in marked inhibition of HBV DNA levels and improvement in serum aminotransferases and hepatic histology in the majority of patients. When stopped, however, most patients relapse and the shortcomings of long-term therapy have been the development of viral resistance in up to one-quarter of patients within a year and a higher percentage with more prolonged therapy. Future approaches of therapy of promise for hepatitis B are combinations of lamivudine with interferon and other antiviral nucleoside analogues. The currently recommended therapy of chronic hepatitis C is a 12- to 18-month course of alpha interferon in doses of 3 million units three times a week: a regimen that results in sustained clearance of hepatitis C virus (HCV) RNA in approximately 20% of patients. Sustained responses have been associated with marked improvements in hepatic histology and long-term studies indicate that the majority of patients remain free of virus in serum and liver, suggesting a 'cure' of infection. Responses to interferon correlate to some degree with clinical and virological features, including young age, absence of hepatic fibrosis, low levels of HCV RNA in serum and HCV genotypes 2 and 3. (ABSTRACT TRUNCATED) PMID:9705540

Hoofnagle, J H



Aggressive hepatitis (image)  


Chronic active hepatitis is a liver disease caused by infection, drug ingestion, metabolic or autoimmune disorders. Necrosis (death) of liver cells, inflammation and fibrosis may lead to liver failure. Death within 5 years ...


Living With Hepatitis B  


... healthy liver is to strictly limit or avoid alcohol. Chronic hepatitis B and alcohol is a dangerous mixture. Studies have shown that even small amounts of alcohol can cause damage to an already weakened liver. ...


Hepatitis B Vaccine (Recombinant)  

Center for Biologics Evaluation and Research (CBER)

... Hepatitis B Vaccine (Recombinant). -. Products. Engerix-B; Recombivax HB. -. Contact FDA. (800) 835-4709. (301) 827-1800. ... More results from


Children with hepatitis C  

Microsoft Academic Search

Hepatitis C affects thousands of children throughout the world. Most children acquire the virus through vertical transmission,\\u000a although parenteral routes of acquisition are also common. Hepatitis C progresses slowly, with mild biopsy findings and no\\u000a symptoms in most children and in many adults. However, significant liver inflammation and fibrosis can occur in childhood.\\u000a Trials of antiviral therapy with interferon and

Girish Subba Rao; Jean Pappas Molleston



Laparoscopic anatomical hepatic resection  

Microsoft Academic Search

.   Four patients underwent a laparoscopic left hepatic resection for solid tumor, two for metastasis from colonic cancer, and\\u000a two for focal nodular hyperplasia (final diagnosis). The procedure was performed according to the rules of conventional hepatic\\u000a surgery and cancer surgery. No blood transfusion was necessary. No surgical complication occurred. In malignant disease, laparoscopy\\u000a allows a good staging and the

G. Samama; L. Chiche; J. L. Bréfort; Y. Le Roux



Implications of Giant Craters on Mathilde  

NASA Astrophysics Data System (ADS)

The recent flyby of asteroid [253] Mathilde by the Near Earth Asteroid Rendezvous spacecraft (NEAR) was the first spacecraft encounter with a C-type asteroid. A striking result of the encounter is that there are five giant craters, whose diameters are comparable to the 26.5 km mean radius of Mathilde, on the single observed face of the asteroid. It seems remarkable that Mathilde survived such an onslaught of giant impacts without disrupting. Previous workers have noted that Mathilde's low measured density of 1.3 g/cc, which implies a porous composition, increases its resistance to disruption. We point out that oblique impacts are also key to understanding the geology of Mathilde. Relative to normal impacts, oblique impacts are less likely to disrupt a target, produce less ejecta, and most often do not create elongated craters, consistent with the observed morphology of giant craters on Mathilde. For a realistic projectile population, the probability of giant cratering on Mathilde is 2.1 to 2.6 times greater than that of disruption, and the probability of Mathilde's surviving five giant impacts is 1 in 5 to 1in 7.

Cheng, Andrew; Barnouin-Jha, O.



Mechanisms of Hepatic Fibrogenesis  

PubMed Central

Substantial improvements in the treatment of chronic liver disease have accelerated interest in uncovering the mechanisms underlying hepatic fibrosis and its resolution. Activation of resident hepatic stellate cells into proliferative, contractile, and fibrogenic cells in liver injury remains a dominant theme driving the field. However, several new areas of rapid progress in the past 5–10 years also have taken root, including: (1) identification of different fibrogenic populations apart from resident stellate cells, for example, portal fibroblasts, fibrocytes, and bone-marrow– derived cells, as well as cells derived from epithelial mesenchymal transition; (2) emergence of stellate cells as finely regulated determinants of hepatic inflammation and immunity; (3) elucidation of multiple pathways controlling gene expression during stellate cell activation including transcriptional, post-transcriptional, and epigenetic mechanisms; (4) recognition of disease-specific pathways of fibrogenesis; (5) re-emergence of hepatic macrophages as determinants of matrix degradation in fibrosis resolution and the importance of matrix cross-linking and scar maturation in determining reversibility; and (6) hints that hepatic stellate cells may contribute to hepatic stem cell behavior, cancer, and regeneration. Clinical and translational implications of these advances have become clear, and have begun to impact significantly on the management and outlook of patients with chronic liver disease.

Friedman, Scott L.



Hepatitis B Guidelines for Pregnant Women  


Hepatitis B Foundation Cause for a Cure Hepatitis B Foundation · 3805 Old Easton Road, ... PA 18902 · 215-489-4900 · Hepatitis B Guidelines for Pregnant Women What is hepatitis ...


Propranolol-mediated attenuation of mmp-9 excretion in infants with hemangiomas.  


IMPORTANCE Infantile hemangiomas (IHs) vary substantially in localization and extent of tissue involvement, but IH biological progression is remarkably unique and predictable. Propranolol is an effective treatment for symptomatic IH, but its mechanism of action remains unknown and understudied. OBJECTIVE To compare excreted proteins in infants with IH being treated with propranolol vs prednisolone. DESIGN, SETTING, AND PARTICIPANTS Exploratory urine proteomics profiling of patients with IH from July 2010 to September 2012 at a tertiary pediatric hospital. Participants were infants with IH treated at our institution who were participating in a blinded, randomized trial comparing prednisolone vs propranolol. They ranged in age from 14 days to 15 months at enrollment. Exclusion criteria included a history of diabetes mellitus, asthma, and/or cardiovascular disease including hypertension or hypotension. Urine samples were longitudinally collected from all participants. Specimens were desalted, concentrated, and gel fractionated, and the protein content was identified using liquid chromatography tandem mass spectrometry. Western blot analyses and enzyme-linked immunosorbent assays (ELISAs) were performed to validate mass spectrometry findings. INTERVENTION Treatment with propranolol or prednisolone administered starting before the age of 6 months. MAIN OUTCOMES AND MEASURES Proteins present in urine samples and change in urinary levels of proteins over time. RESULTS Samples were obtained from 3 patients treated with prednisolone, 3 patients treated with propranolol, and 5 untreated controls with IH. More than 1000 urinary proteins were identified by proteomics. Patients treated with propranolol demonstrated attenuation of excreted matrix metalloproteinase 9 (MMP-9) in urine over the proliferative phase of the condition compared with prednisolone-treated patients. These findings were validated with Western blot analysis and quantified with ELISA, which confirmed mean urinary MMP-9 levels in the first year of life to be significantly lower in propranolol-treated patients with IH compared with prednisolone-treated patients with IH (0.118 vs 0.501 ng/mL; P?=?.03) or with nontreated patients with IH (0.118 vs 3.69 ng/mL; P?=?.02). CONCLUSIONS AND RELEVANCE Propranolol treatment decreases urinary excretion of MMP-9 in patients with IH. Matrix metalloproteinase 9 may be a biomarker for IH propranolol responsiveness, and its signaling pathways may represent the molecular target of this drug. PMID:24135743

Thaivalappil, Silpa; Bauman, Nancy; Saieg, Amarel; Movius, Elizabeth; Brown, Kristy J; Preciado, Diego



IL-17A plays a critical role in the pathogenesis of liver fibrosis through hepatic stellate cell activation.  


Liver fibrosis is a severe, life-threatening clinical condition resulting from nonresolving hepatitis of different origins. IL-17A is critical in inflammation, but its relation to liver fibrosis remains elusive. We find increased IL-17A expression in fibrotic livers from HBV-infected patients undergoing partial hepatectomy because of cirrhosis-related early-stage hepatocellular carcinoma in comparison with control nonfibrotic livers from uninfected patients with hepatic hemangioma. In fibrotic livers, IL-17A immunoreactivity localizes to the inflammatory infiltrate. In experimental carbon tetrachloride-induced liver fibrosis of IL-17RA-deficient mice, we observe reduced neutrophil influx, proinflammatory cytokines, hepatocellular necrosis, inflammation, and fibrosis as compared with control C57BL/6 mice. IL-17A is produced by neutrophils and T lymphocytes expressing the Th17 lineage-specific transcription factor Retinoic acid receptor-related orphan receptor ?t. Furthermore, hepatic stellate cells (HSCs) isolated from naive C57BL/6 mice respond to IL-17A with increased IL-6, ?-smooth muscle actin, collagen, and TGF-? mRNA expression, suggesting an IL-17A-driven fibrotic process. Pharmacologic ERK1/2 or p38 inhibition significantly attenuated IL-17A-induced HSC activation and collagen expression. In conclusion, IL-17A(+) Retinoic acid receptor-related orphan receptor ?t(+) neutrophils and T cells are recruited into the injured liver driving a chronic, fibrotic hepatitis. IL-17A-dependent HSC activation may be critical for liver fibrosis. Thus, blockade of IL-17A could potentially benefit patients with chronic hepatitis and liver fibrosis. PMID:23842754

Tan, Zhongming; Qian, Xiaofeng; Jiang, Runqiu; Liu, Qianghui; Wang, Youjing; Chen, Chen; Wang, Xuehao; Ryffel, Bernhard; Sun, Beicheng



Giant gravitons: A collective coordinate approach  

NASA Astrophysics Data System (ADS)

In this paper I describe a collective coordinate approach to the study of giant graviton states and their excitations in various field theories. The method simplifies considerably the understanding of the emergent gauge symmetry of these configurations, as well as the calculation of the spectrum of strings stretched between the giant gravitons. There is a limit where these results reproduce the one-loop dispersion relation for giant magnons. I also show that this method gives rise to a simple geometric interpretation of a Higgs mechanism for the emergent gauge symmetry which parallels the holographic dual realization of these states: the effective Higgs condensate is the geometric separation of D-branes in the collective coordinate geometry.

Berenstein, David



Baroclinic Instability on Hot Gas Giant Planets  

NASA Astrophysics Data System (ADS)

We investigate baroclinic instability under conditions applicable to hot extrasolar giant planets. Using a global general circulation model (GCM) which solves the primitive equations, we show that large-scale jets similar to those observed in current GCM simulations of hot gas giant planets are baroclinically unstable at a wide range of latitudes. For jets located at latitudes away from the equator, the growth rate and the most unstable mode are in good agreement with linear analysis. For jets located at or near the equator, the instability is strong at the jet flanks, rather than at the core. Thus, baroclinic instability is significant for understanding characteristics of hot gas giant planet atmospheres. We also demonstrate that the instability is not captured in simulations with low resolution and/or high artificial viscosity.

Polichtchouk, I.; Cho, J. Y.-K.



Growing Giant Clam (Tridacna Derasa) in Aquaculture Effluent  

Microsoft Academic Search

Juvenile giant clams (Hippopus spp. and Tridacna spp.) are highly valuable and popular in the aquarium trade due to their brightly colored mantles with various patterns. Giant clams are unique bivalves in that they possess symbiotic zooxanthellae (Symbiodinium). A previous study by the authors demonstrated the feasibility of culturing giant clams in aquaculture effluent. Among the four species tested (Tridacna

Junda Lin; Maria Sparsis; Randolph W. Hagood



JHK Photometry of CN-Rich Field Giants. Abstract Only.  

National Technical Information Service (NTIS)

Infrared JHK photometry was obtained for a sample of CN-rich Population I field giants. On average, the CN-rich giants show a modest color separation from more typical field giants of near solar abundance in the J-H, H-K two-color diagram. Many of the CN ...

G. H. Smith




SciTech Connect

We observed the Crab pulsar with the 43 m telescope in Green Bank, WV over a timespan of 15 months. In total we obtained 100 hr of data at 1.2 GHz and seven hours at 330 MHz, resulting in a sample of about 95,000 giant pulses (GPs). This is the largest sample, to date, of GPs from the Crab pulsar taken with the same telescope and backend and analyzed as one data set. We calculated power-law fits to amplitude distributions for main pulse (MP) and interpulse (IP) GPs, resulting in indices in the range of 2.1-3.1 for MP GPs at 1.2 GHz and in the range of 2.5-3.0 and 2.4-3.1 for MP and IP GPs at 330 MHz. We also correlated the GPs at 1.2 GHz with GPs from the Robert C. Byrd Green Bank Telescope (GBT), which were obtained simultaneously at a higher frequency (8.9 GHz) over a span of 26 hr. In total, 7933 GPs from the 43 m telescope at 1.2 GHz and 39,900 GPs from the GBT were recorded during these contemporaneous observations. At 1.2 GHz, 236 (3%) MP GPs and 23 (5%) IP GPs were detected at 8.9 GHz, both with zero chance probability. Another 15 (4%) low-frequency IP GPs were detected within one spin period of high-frequency IP GPs, with a chance probability of 9%. This indicates that the emission processes at high and low radio frequencies are related, despite significant pulse profile shape differences. The 43 m GPs were also correlated with Fermi {gamma}-ray photons to see if increased pair production in the magnetosphere is the mechanism responsible for GP emission. A total of 92,022 GPs and 393 {gamma}-ray photons were used in this correlation analysis. No significant correlations were found between GPs and {gamma}-ray photons. This indicates that increased pair production in the magnetosphere is likely not the dominant cause of GPs. Possible methods of GP production may be increased coherence of synchrotron emission or changes in beaming direction.

Mickaliger, M. B.; McLaughlin, M. A.; Lorimer, D. R.; Palliyaguru, N. [Department of Physics, West Virginia University, Morgantown, WV 26506 (United States); Langston, G. I. [National Radio Astronomy Observatory, Green Bank, WV 24944 (United States); Bilous, A. V. [Department of Astronomy, University of Virginia, P.O. Box 400325, Charlottesville, VA 22904 (United States); Kondratiev, V. I. [Netherlands Institute for Radio Astronomy (ASTRON), Postbus 2, 7990 AA Dwingeloo (Netherlands); Lyutikov, M. [Department of Physics, Purdue University, 525 Northwestern Avenue, West Lafayette, IN 47907-2036 (United States); Ransom, S. M. [National Radio Astronomy Observatory, Charlottesville, VA 22903 (United States)



Giant cell tumor of uterus resembling osseous giant cell tumor: case report and review of literature.  


Osteoclast-like giant cells (OLGCs) are multinucleated cells of histiocytic lineage and have been identified in a wide array of neoplasms. In the uterus, they have most frequently been reported in association with leiomyosarcomas. This article describes a case of an osteoclast-like giant cell-rich uterine tumor that was essentially indistinguishable at the morphologic and immunophenotypic levels, from typical giant cell tumor of bone. This is the first example of such a case that has been reported in the uterus to the authors' knowledge. PMID:22494996

Manglik, Niti; Sawicki, Janusz; Saad, Andre; Fadare, Oluwole; Soslow, Robert; Liang, Sharon X



Polarimetry of Li-rich giants  

NASA Astrophysics Data System (ADS)

Context: .Protoplanetary nebulae typically present non-spherical envelopes. The origin of such geometry is still controversial. There are indications that it may be carried over from an earlier phase of stellar evolution, such as the AGB phase. But how early in the star's evolution does the non-spherical envelope appear? Aims.Li-rich giants show dusty circumstellar envelopes that can help answer that question. We study a sample of fourteen Li-rich giants using optical polarimetry in order to detect non-spherical envelopes around them. Methods.We used the IAGPOL imaging polarimeter to obtain optical linear polarization measurements in {V} band. Foreground polarization was estimated using the field stars in each CCD frame.Results.After foreground polarization was removed, seven objects presented low intrinsic polarization (0.19-0.34)% and two (V859 Aql and GCSS 557) showed high intrinsic polarization values (0.87-1.16)%. This intrinsic polarization suggests that Li-rich giants present a non-spherical distribution of circumstellar dust. The intrinsic polarization level is probably related to the viewing angle of the envelope, with higher levels indicating objects viewed closer to edge-on. The correlation of the observed polarization with optical color excess gives additional support to the circumstellar origin of the intrinsic polarization in Li-rich giants. The intrinsic polarization correlates even better with the IRAS 25 ? m far infrared emission. Analysis of spectral energy distributions for the sample show dust temperatures for the envelopes that tend to be between 190 and 260 K. We suggest that dust scattering is indeed responsible for the optical intrinsic polarization in Li-rich giants.Conclusions.Our findings indicate that non-spherical envelopes may appear as early as the red giant phase of stellar evolution.

Pereyra, A.; Castilho, B. V.; Magalhães, A. M.



Antibody to hepatitis B core antigen in chronic active hepatitis  

Microsoft Academic Search

Antibody to hepatitis B core antigen (anti-HBc), which has been assumed to be a more sensitive indicator of hepatitis B virus replication than hepatitis B surface antigen (HBsAg), was detected in the sera of 26 of our 65 patients with HBsAg-negative chronic active hepatitis. Thus despite the absence of HBsAg the liver disease could be the consequence of chronic infection

P Bories; P Coursaget; A Goudeau; C Degott; P Maupas; J P Benhamou



Giant cell fibroblastoma of the penis.  


Giant cell fibroblastoma (GCF) is an uncommon fibroblastic tumor of childhood. Appearing as superficial, poorly circumscribed masses, they are characterized histologically by a mixture of cellular and angiectoid areas with empty cleft-like spaces, lined by spindle-shaped and multinucleated giant cells. We present a case of an 11-month-old boy with penile GCF treated with local excision. The patient presented with a recurrent penile mass 1 year later and underwent repeat excision. Pathologic examination confirmed recurrent GCF. GCF is a benign, but locally recurrent tumor, as demonstrated by our case. To our knowledge, no cases of penile involvement have been previously reported. PMID:16904472

Woo, Lynn L; Kuang, Wayne; Zhou, Ming; Ross, Jonathan



Granulomatous variant of giant centrifugal miliaria profunda.  


Two infants presented with multiple asymptomatic papules and geographic and annular plaques over the extensor aspect of the upper and lower extremities and trunk. Skin biopsy of both lesions showed plugged and hyperplastic dilated acrosryingia and deep dermal ducts, along with granulomatous inflammatory reaction. These lesions showed self-healing with complete resolution. A previous report described similar clinical and histopathologic features and labeled it giant centrifugal miliaria profunda. Because of the large granulomatous plaques and deep infiltrate, we propose that it was a granulomatous variant of giant centrifugal miliaria profunda. We report these cases for their rarity and self-healing nature. PMID:22276567

Doshi, Bhavana R; Mahajan, Sunanda; Kharkar, Vidya; Khopkar, Uday S



The giant cell in cholesterol resorption.  

PubMed Central

Giant cells in the experimental cholesterol granuloma provided a convenient, recognizable cellular model in which to follow the transformation of crystalline cholesterol to liquid lipid. Crystals that were too large to be ingested by individual macrophages were incorporated into a multinucleate cell by a process of circumfusion, and were progressively converted to cholesterol esters within the giant cell. The liquid ester droplets seemed then to be mobilized by mononuclear cells until the entire implant had been resorbed. Images Figs. 1, 5 and 6 Fig. 3 Fig. 4

Bayliss, O. B.



Simultaneous Dual Frequency Observations of Giant Pulses  

NASA Astrophysics Data System (ADS)

Simultaneous data of Giant Pulses in the Crab Pulsar were taken at two widely spaced frequencies, using the detection of a giant pulse at 1.4 GHz at the VLA to trigger the observation of that same pulse period at 0.610 GHz at Green Bank. About 70% of these pulses are seen at both 1.4 and 0.6 GHz, implying they have a bandwidth of at least 0.8 GHz at 1 GHz. At both frequencies, the pulses are characterized by a fast rise and an exponential decay, consistent with scattering in the nebular filament zone only at 0.610 GHz.

Sallmen, S.; Backer, D. C.; Hankins, T.; Moffett, D.; Lundgren, S.


Giant magnetoresistance calculated from first principles  

SciTech Connect

The Layer Korringa Kohn Rostoker-Coherent Potential Approximation technique was used to calculate the low temperature Giant Magnetoresistance from first principles for Co{vert_bar}Cu and permalloy{vert_bar}Cu superlattices. Our calculations predict large giant magnetoresistance ratios for Co{vert_bar}Cu and extremely large ratios for permalloy{vert_bar}Cu for current perpendicular to the layers. Mechanisms such as spin-orbit coupling which mix spin channels are expected to greatly reduce the GMR effect for permalloy{vert_bar}Cu.

Butler, W.H. [Oak Ridge National Lab., TN (United States); MacLaren, J.M. [Tulane Univ., New Orleans, LA (United States). Dept. of Physics; Zhang, X.G. [Univ. of Kentucky, Lexington, KY (United States). Center for Computational Sciences



Lunar origin: role of giant impacts  

SciTech Connect

The explanation that lunar origin involved giant impacts remains attractive. Large planetesimals are consistent with current accretion models, and may have been widely scattered in the early solar system. Their existence is a reasonable, assumption in Moon origin models. Isotopic data require the Moon's formation primarily from local material resembling Earth's upper mantle, not material from elsewhere in the solar system. Giant impacts are stochastic, class predictable events that would provide the required type of ejected Earth mantle material without requiring large moons to form near other planets (a problem with less stochastic processes). Such material may have mixed with incoming meteorites during lunar formation, affecting lunar chemistry.

Hartmann, W.K.



Detection of Hepatitis in Blood.  

National Technical Information Service (NTIS)

A retrospective study of post transfusion hepatitis (PTH) revealed that 24% of PTH was associated with transfusion of hepatitis B antigen (HBAg) as assayed by radioimmunoassay (RIA) or red cell agglutination (RCA). Asubsequent prospective study revealed t...

G. L. Gitnick



Infected hepatic cyst.  


We describe an unusual case involving an infected hepatic cyst. An 88-year-old woman presented with acute onset of right upper quadrant abdominal pain, mild left lower abdominal pain, diarrhea, and fever. On admission, computed tomography revealed multiple hepatic cysts including an 8-cm cyst located in the left medial segment of the liver, which demonstrated a thickened wall enhanced with contrast media. Ultrasonography showed an 8-cm hypoechoic lesion which differed in appearance from the other, anechoic hepatic cysts. The serum concentration of C-reactive protein was 29.8 mg/dL; white blood cell count, 12,800/microL; CA19-9, 96 U/mL; and CEA, 2.2 ng/mL. Diagnosis of infected hepatic cyst was made by percutaneous transhepatic drainage of the cyst. Milky fluid was obtained and the patient's right upper quadrant abdominal pain resolved after drainage. The cyst fluid CA19-9 concentration was 18,000 U/mL. Cytology of the cyst fluid was negative. Serum CA19-9 (41 U/mL) and CEA (1.8 ng/mL) concentrations were improved 1 week after drainage. Escherichia coli was cultured from the drainage fluid. The patient was discharged 27 days after admission. Percutaneous transhepatic drainage is effective in the treatment of infected hepatic cysts. PMID:12749258

Yoshida, Hiroshi; Onda, Masahiko; Tajiri, Takashi; Mamada, Yasuhiro; Taniai, Nobuhiko; Mineta, Sho; Hirakata, Atsushi; Futami, Ryohei; Arima, Yasuo; Inoue, Matsuoh; Hatta, Shigeo; Kishimoto, Akio


Formation of Gas Giant Satellites  

NASA Astrophysics Data System (ADS)

The Jovian and Saturnian regular satellites are believed to have accreted within circumplanetary disks of gas and solids. Such disks probably existed during the final stages of gas planet accretion, because gas inflowing from solar orbit that contained too much angular momentum to fall directly onto the planet would have instead flowed into circumplanetary orbit. As a circumplanetary gas disk viscously diffuses, most of its mass is accreted by the planet while most of its angular momentum (contained in a small fraction of its mass) is transferred outward and escapes. The gas planet disks would have been continually replenished by any ongoing inflow of nebular gas, allowing the disks to persist until the nebula itself dissipated. Here I will discuss a model [1,2,3] in which gas giant satellites form within inflow-supplied circumplanetary disks. Small solids carried into the disk by the inflowing gas provide the raw material for accreting satellites. A satellite grows until it reaches a critical mass for which the timescale for its further growth is comparable to the timescale for its orbit to decay via gravitational interactions with the gas disk. Once a satellite reaches this critical mass (comparable to that of Titan and the Galilean satellites), its orbit spirals inward and if inflow to the disk continues, the satellite will be lost to collision with the planet while a new one grows in its place. The current Jovian and Saturnian satellites represent the last surviving generation of satellites that formed as gas inflow to the circumplanetary disks ended. As the rate of inflow wanes, the disk cools, allowing the final satellites to incorporate substantial ices. For reasonable conditions, this model can account for the general structure (i.e., masses, numbers, and orbital spacings of the large satellites) and overall compositional trends in both the Jovian and Saturnian satellite systems. It implies that the current large satellites accreted slowly (in > 5 × 105 yr), within low-density, 'gas-starved' disks. The model also produces satellite systems that resemble that of Uranus, although its applicability to Uranus depends on how the planet acquired its obliquity. [1] Canup, R.M. & W.R. Ward, Astron. J. 124, 3404 (2002); [2] Canup, R.M. & W.R. Ward, Nature 441, 834 (2006). [3] Ward, W.R. & R.M. Canup, submitted (2008). Support from NASA's OPR and PGG programs is gratefully acknowledged.

Canup, R. M.



Mapping Directly Imaged Giant Exoplanets  

NASA Astrophysics Data System (ADS)

With the increasing number of directly imaged giant exoplanets, the current atmosphere models are often not capable of fully explaining the spectra and luminosity of the sources. A particularly challenging component of the atmosphere models is the formation and properties of condensate cloud layers, which fundamentally impact the energetics, opacity, and evolution of the planets. Here we present a suite of techniques that can be used to estimate the level of rotational modulations these planets may show. We propose that the time-resolved observations of such periodic photometric and spectroscopic variations of extrasolar planets due to their rotation can be used as a powerful tool to probe the heterogeneity of their optical surfaces. In this paper, we develop simulations to explore the capabilities of current and next-generation ground- and space-based instruments for this technique. We address and discuss the following questions: (1) what planet properties can be deduced from the light curve and/or spectra, and in particular can we determine rotation periods, spot coverage, spot colors, and spot spectra?; (2) what is the optimal configuration of instrument/wavelength/temporal sampling required for these measurements?; and (3) can principal component analysis be used to invert the light curve and deduce the surface map of the planet? Our simulations describe the expected spectral differences between homogeneous (clear or cloudy) and patchy atmospheres, outline the significance of the dominant absorption features of H2O, CH4, and CO, and provide a method to distinguish these two types of atmospheres. Assuming surfaces with and without clouds for most currently imaged planets the current models predict the largest variations in the J band. Simulated photometry from current and future instruments is used to estimate the level of detectable photometric variations. We conclude that future instruments will be able to recover not only the rotation periods, cloud cover, cloud colors, and spectra but even cloud evolution. We also show that a longitudinal map of the planet's atmosphere can be deduced from its disk-integrated light curves.

Kostov, Veselin; Apai, Dániel



Determination of ganglioside composition and structure in human brain hemangioma by chip-based nanoelectrospray ionization tandem mass spectrometry.  


We report here on a preliminary investigation of ganglioside composition and structure in human hemangioma, a benign tumor in the frontal cortex (HFC) in comparison to normal frontal cortex (NFC) tissue using for the first time advanced mass spectrometric methods based on fully automated chip-nanoelectrospray (nanoESI) high-capacity ion trap (HCT) and collision-induced dissociation (CID). The high ionization efficiency, sensitivity and reproducibility provided by the chip-nanoESI approach allowed for a reliable MS-based ganglioside comparative assay. Unlike NFC, ganglioside mixture extracted from HFC was found dominated by species of short glycan chains exhibiting lower overall sialic acid content. In HFC, only GT1 (d18:1/20:0), and GT3 (d18:1/25:1) polysialylated species were detected. Interestingly, none of these trisialylated forms was detected in NFC, suggesting that such components might selectively be associated with HFC. Unlike the case of previously investigated high malignancy gliosarcoma, in HFC one modified O-Ac-GD2 and one modified O-Ac-GM4 gangliosides were observed. This aspect suggests that these O-acetylated structures could be associated with cerebral tumors having reduced malignancy grade. Fragmentation analysis by CID in MS(2) mode using as precursors the ions corresponding to GT1 (d18:1/20:0) and GD1 (d18:1/20:0) provided data corroborating for the first time the presence of the common GT1a and GT1b isomers and the incidence of unusual GT1c and GT1d glycoforms in brain hemangioma tumor. PMID:19841910

Schiopu, Catalin; Flangea, Corina; Capitan, Florina; Serb, Alina; Vukeli?, Zeljka; Kalanj-Bognar, Svjetlana; Sisu, Eugen; Przybylski, Michael; Zamfir, Alina D



Acute hepatic failure in children.  

PubMed Central

Many diseases may present as acute hepatic failure in the pediatric age group, including viral hepatitis A and B, adverse drug reactions, both toxic and "hepatitic," and inherited metabolic disorders such as tyrosinemia, alpha 1 antitrypsin deficiency, and Wilson's disease. Management is primarily supportive, with care taken to anticipate the known complications of hepatic failure. Few "curative" therapies are known, although attempts at stimulating hepatic regeneration may be helpful. Images FIG. 1 FIG. 3 FIG. 4

Riely, C. A.



Polymorphic tetranucleotide microsatellites for Cope's giant salamander (Dicamptodon copei) and Pacific giant salamander (Dicamptodon tenebrosus).  


We present primers and amplification conditions for 15 microsatellite loci developed for the Cope's giant salamander (Dicamptodon copei), 14 of which are tetranucleotide repeats. Cross-species amplification revealed 10 of these loci to also be polymorphic in the Pacific giant salamander (Dicamptodon tenebrosus). Several loci produced nonoverlapping allelic ranges between the two species and may be useful in species identification. These polymorphic microsatellite loci are potentially useful for future studies of population genetics in dicamptodontid salamanders. PMID:21585975

Steele, C A; Baumsteiger, J; Storfer, A




SciTech Connect

We measure the redshift distribution of a sample of 28 giant arcs discovered as a part of the Sloan Giant Arcs Survey. Gemini/GMOS-North spectroscopy provides precise redshifts for 24 arcs, and 'redshift desert' constrains for the remaining 4 arcs. This is a direct measurement of the redshift distribution of a uniformly selected sample of bright giant arcs, which is an observable that can be used to inform efforts to predict giant arc statistics. Our primary giant arc sample has a median redshift z = 1.821 and nearly two-thirds of the arcs, 64%, are sources at z {approx}> 1.4, indicating that the population of background sources that are strongly lensed into bright giant arcs resides primarily at high redshift. We also analyze the distribution of redshifts for 19 secondary strongly lensed background sources that are not visually apparent in Sloan Digital Sky Survey imaging, but were identified in deeper follow-up imaging of the lensing cluster fields. Our redshift sample for the secondary sources is not spectroscopically complete, but combining it with our primary giant arc sample suggests that a large fraction of all background galaxies that are strongly lensed by foreground clusters reside at z {approx}> 1.4. Kolmogorov-Smirnov tests indicate that our well-selected, spectroscopically complete primary giant arc redshift sample can be reproduced with a model distribution that is constructed from a combination of results from studies of strong-lensing clusters in numerical simulations and observational constraints on the galaxy luminosity function.

Bayliss, Matthew B.; Gladders, Michael D.; Koester, Benjamin P. [Department of Astronomy and Astrophysics, University of Chicago, 5640 South Ellis Avenue, Chicago, IL 60637 (United States); Oguri, Masamune [Division of Theoretical Astronomy, National Astronomical Observatory of Japan, 2-21-1 Osawa, Mitako, Tokyo 181-8588 (Japan); Hennawi, Joseph F. [Max-Planck-Institut f'uer Astronomie Koenigstuhl 17, D-69117, Heidelberg (Germany); Sharon, Keren [Kavli Institute for Cosmological Physics, University of Chicago, 5640 South Ellis Avenue, Chicago, IL 60637 (United States); Dahle, Haakon, E-mail: [Institute of Theoretical Astrophysics, University of Oslo, P.O. Box 1029, Blindern, N-0315 Oslo (Norway)



New aspects of hepatic fibrosis  

Microsoft Academic Search

Hepatic stellate cells are the major source of extracellular matrix proteins in hepatic fibrosis, including Type I collagen. In response to liver injury, the hepatic stellate cells change from a quiescent to an activated phenotype. This activation process includes a phenotypic change to a myofibroblast-like cell, increased proliferation rate, loss of retinoid stores, increased production of extracellular matrix proteins, chemokines,

David A. Brenner; Tim Waterboer; Sung Kyu Choi; Jeffrey N. Lindquist; Branko Stefanovic; Elmar Burchardt; Mitsui Yamauchi; Andrea Gillan; Richard A. Rippe



Viral hepatitis in the Arctic  

Microsoft Academic Search

Objectives. Summarize research on viral hepatitis in indigenous populations in the Arctic. Study De- sign. Literature review. Methods. Medline search from 1966-2003. Results. High prevalence rates of total hepatitis A antibody of > 50% and of hepatitis B of between 22% in Alaska and 42% in Greenland for total infection and between 3% in Canada and 12% in Siberia for

Brian J McMahon


Natural history of hepatitis C  

Microsoft Academic Search

Ten years after the discovery of the hepatitis C virus (HCV) and its association with NANB hepatitis as a major cause of chronic liver disease worldwide, our knowledge of the natural history of hepatitis C is still limited. The asymptomatic course of the disease in most patients, its slow and silent progression and heterogeneous outcome and the widespread use of

Alfredo Alberti; Liliana Chemello; Luisa Benvegnù



Natural history of hepatitis C  

Microsoft Academic Search

It is now widely accepted that 85% or more of individuals with acute hepatitis C virus (HCV) infection progress to chronic hepatitis, and chronic hepatitis C is a known risk factor for cirrhosis and hepatocellular carcinoma (HCC). However, there has been much controversy about the inevitability of developing cirrhosis and HCC and the time frames in which they are likely

Leonard B Seeff



Safety of lamivudine treatment for chronic hepatitis B in early pregnancy  

PubMed Central

AIM: To evaluate the safety of lamivudine (LAM) treatment for chronic hepatitis B in early pregnancy. METHODS: A total of 92 pregnant women who received LAM treatment either before pregnancy or in early pregnancy were enrolled in this study. All of the pregnant women volunteered to take lamivudine during pregnancy and were not co-infected with hepatitis C virus, human immunode?ciency virus, cytomegalovirus, or other viruses. All infants received passive-active immunoprophylaxis with 200 IU hepatitis B immunoglobulin and three doses of 10 ?g hepatitis B vaccines (0-1-6 mo) according to the guidelines for the prevention and treatment of chronic hepatitis B. Adverse events were observed throughout the entire pregnancy and perinatal period, and the effectiveness of lamivudine treatment for blocking mother-to-infant transmission of hepatitis B virus (HBV) was evaluated. All adverse events in mothers and infants during pregnancy and the perinatal period and the HBV mother-to-infant transmission blocking rate were compared with the literature. RESULTS: Among the 92 pregnant women, spontaneous abortions occurred in 11 cases, while 3 mothers had a second pregnancy after the initial abortion; 72 mothers delivered 73 live infants, of whom 68 infants were followed up for no less than 6 mo, and 12 mothers were still pregnant. During pregnancy, the main maternal adverse events were vaginitis (12/72, 16.7%), spontaneous abortion (11/95, 11.6%), and gestational diabetes (6/72, 8.3%); only one case had 1-2 degree elevation of the creatine kinase level (195 U/L). During the perinatal period, the main maternal adverse events were premature rupture of the membranes (8/72, 11.1%), preterm delivery (5/72, 6.9%), and meconium staining of the amniotic fluid (4/72, 5.6%). In addition, 2 infants were found to have congenital abnormalities; 1 had a scalp hemangioma that did not change in size until 7 mo, and the other had early cerebral palsy, but with rehabilitation training, the infant’s motor functions became totally normal at 2 years of age. The incidence of adverse events among the mothers or abnormalities in the infants was not higher than that of normal mothers or HBV-infected mothers who did not receive lamivudine treatment. In only 2 cases, mother-to-infant transmission blocking failed; the blocking rate was 97.1% (66/68), which was higher than has been previously reported. CONCLUSION: Lamivudine treatment is safe for chronic HBV-infected pregnant mothers and their fetuses with a gestational age of less than 12 wk or throughout the entire pregnancy.

Yi, Wei; Liu, Min; Cai, Hao-Dong



[Minimal hepatic encephalopathy].  


Minimal hepatic encephalopathy (MHE) is defined by the presence of neurophysiological alterations,with an important impact in the quality of life, in the risk of performing dangerous tasks as leading cars and heavy machinery and increases risk of overt hepatic encephalopathy. MHE is present in a third of cirrhotic depending on liver function. Psychometric and neurophysiologic test are used in the diagnosis of MHE, mainly PHES (Psychometric Hepatic Encephalopathy Score) battery, electroencephalogram, evoked potentials and measurement of the critical flicker frequency. Oral glutamine challenge (OGC) measures intestinal ammonia production after glutamine intake and indirectly intestinal glutaminase activity. Altered OGC in patients with MHE predicts short-time survival. In conclusion,MHE is the first stage in HE syndrome, affect to a third of cirrhotic and worsen quality of life. There are useful and easy-to-use diagnostic tests and new therapeutic options are warranted. PMID:19666316

Jover, M; Hoyas, E; Grande, L; Romero-Gómez, M



Treatments for hepatitis B.  


New optimism surrounds treatments for chronic hepatitis B (CHB). Interferon- alpha , lamivudine, and adefovir dipivoxil are currently approved by the United States Food and Drug Administration for the treatment of CHB. All 3 treatments possess unique characteristics with respect to their side effect profiles, potencies, and treatment niches within the spectrum of CHB. New agents, which are in various stages of clinical development, represent potential improvements within existing, as well as novel, classes of antiviral therapy, and they offer significant promise of a cure for the many patients with chronic and progressive hepatitis B. However, there remain many challenges in understanding the implications of drug resistance, the role of combination therapy, and how to define the response to therapy within subsets of patients with hepatitis B. PMID:15494913

Asmuth, David M; Nguyen, Hien H; Melcher, Gregory P; Cohen, Stuart H; Pollard, Richard B



[Habitat selection attributes of giant panda].  


Based on the 1997-2009 inventory data of Wanglang Nature Reserve, the habitat selection attributes of giant panda were studied from the aspects of topography, forest community structure, and main feeding bamboo by the methods of frequency distribution and Bailey. The giant panda had obvious habitat preferences. Topographically, the preferred microhabitat was on the even or convex slopes at the ridge, top, or middle part of mountain body at an elevation 2500-3000 m, with southwest aspect, 6 degrees-30 degrees, and the distance to the nearest water source > 300 m. As for the forest community structure, the giant panda preferred the microhabitat with the bamboo succeeded from secondary forest or mixed conifer and broad-leaved forest, and with the average tree height being 20-29 m and the shrub coverage being 0-24%. The preferred main feeding bamboo by the giant panda was the growing well Fargesia denudate with an average height of 2-5 m and the coverage of > 50%. PMID:21608270

Kang, Dong-Wei; Zhao, Zhi-Jiang; Guo, Wen-Xia; Tan, Liu-Yi; Kang, Wen; Li, Jun-Qing



Deep jets on gas-giant planets  

Microsoft Academic Search

Three-dimensional numerical simulations of the atmospheric flow on giant planets using the primitive equations show that shallow thermal forcing confined to pressures near the cloud tops can produce deep zonal winds from the tropopause all the way down to the bottom of the atmosphere. These deep winds can attain speeds comparable to the zonal jet speeds within the shallow, forced

Yuan Lian; Adam P. Showman



[Management of giant inguinal hernias: five cases].  


In Africa, difficulties in health care access and illiteracy promote the development of giant inguinal hernias. Management of these hernias can be very challenging, according to the risk of replacing the intestines into the abdominal cavity. We report five cases in Senegal. PMID:23448670

Diop, B; Sall, I; Ba, P A; Konaté, I; Sy, A; Wane, Y; Sarré, S M


Giant retinal tears after pars plana vitrectomy  

Microsoft Academic Search

Vitreous surgery is used to treat complicated vitreo-retinal pathology. Retinal tears are a serious complication of vitreous surgery. In this report, the development of giant retinal tears in four eyes after pars plana vitrectomy for posterior segment pathology is described. The pathogenesis and implications of this serious and infrequent complication are discussed.

Ahmed M Abu El-Asrar



[Giant melanoma of the scalp: Case report].  


We present a case of giant melanoma of the scalp observed in our department. It is a rare but very aggressive pathology which is generally treated by radical surgery. We emphasize early diagnosis because a large extension of the tumor can lead to the need of a very extensive surgical resection. Prognosis is very severe despite adjuvant medical treatments. PMID:23808109

Calteux, N; Berchem, G; Schmid, N; Nebendahl, J; Fischer, G



Giant magnetoimpedance materials: Fundamentals and applications  

Microsoft Academic Search

Since the discovery of the magnetoimpedance (MI) effect just over a decade ago, international research interest into the giant magnetoimpedance (GMI) effect has been growing. This article aims to provide a comprehensive summary of the GMI topic, encompassing fundamental understanding of the GMI phenomena, the processing and properties of GMI materials and the design and application of GMI-based magnetic sensors.

Manh-Huong Phan; Hua-Xin Peng



Star cluster disruption by giant molecular clouds  

Microsoft Academic Search

We investigate encounters between giant molecular clouds (GMCs) and star clusters. We propose a single expression for the energy gain of a cluster due to an encounter with a GMC, valid for all encounter distances and GMC properties. This relation is verified with N-body simulations of cluster-GMC encounters, where the GMC is represented by a moving analytical potential. Excellent agreement

M. Gieles; S. F. Portegies Zwart; H. Baumgardt; E. Athanassoula; M. Sipior; J. Leenaarts



Giant diverticulum of the sigmoid colon  

Microsoft Academic Search

While diverticulosis of the colon is a relatively common disease, a solitary giant diverticulum (GD) of the sigmoid is rare. Although there exist some theories about the formation of a GD, none is really conclusive. Sym[toms are similar to diverticular disease, and diagnosis is easy with the aid of radiology. Early surgical treatment is necessary since the complication rate is

A. Naber; A.-M. Sliutz; H. Freitas



Structure and evolution of giant molecular clouds  

Microsoft Academic Search

CO survey data supporting the hypothesis that giant molecular clouds (GMCs) form from associations of smaller molecular clouds are analyzed. Voids of GMCs observed in galactic regions are examined; the voids exist because GMCs are concentrated in spiral arms and are on noncircular orbits. GMCs with high brightness temperatures are found only in regions of l, b and v space,

A. S. Stark



Resolved Properties of Extragalactic Giant Molecular Clouds  

Microsoft Academic Search

Giant molecular clouds (GMCs) are the major reservoirs of molecular gas in galaxies, and the starting point for star formation. As such, their properties play a key role in setting the initial conditions for the formation of stars. We present a comprehensive combined inteferometric\\/single-dish study of the resolved GMC properties in a number of extragalactic systems, including both normal and

Alberto D. Bolatto; Adam K. Leroy; Erik Rosolowsky; Fabian Walter; Leo Blitz



Think big – giant genes in bacteria  

Microsoft Academic Search

Long genes should be rare in archaea and eubacteria because of the demanding costs of time and resources for protein production. The search in 580 sequenced prokaryotic genomes, however, revealed 0.2% of all genes to be longer than 5 kb (absolute number: 3732 genes). Eighty giant bacterial genes of more than 20 kb in length were identified in 47 taxa

Oleg Reva; Burkhard Tümmler