Sample records for giant hepatic hemangioma

  1. Spontaneous rupture of a giant hepatic hemangioma-report of a case.

    PubMed

    Gupta, Shahana; Agarwal, Vikash; Acharya, Anadi Nath

    2012-10-01

    Hemangioma is the commonest benign hepatic neoplasm. Most cases are asymptomatic. Spontaneous rupture is rare (1-4%). Only 34 cases have been reported in adults. None had history of trauma. We report a case, the first from India of spontaneous rupture of a giant hepatic hemangioma, in a 25 year old male presenting with acute abdomen. He underwent right hepatectomy. Histopathology suggested cavernous hemangioma. PMID:24082605

  2. Giant cavernous hemangioma coexistent with diffuse hepatic hemangiomatosis presenting as portal vein thrombosis and hepatic lobar atrophy

    PubMed Central

    2014-01-01

    A combination of giant hepatic hemangioma and diffuse hemangiomatosis is extremely rare in adults. Even when they are large, hemangiomas are soft and rarely compress adjacent structures. A 78-year-old man presented with abdominal pain and distension. Ultrasonography, computed tomography, and magnetic resonance imaging demonstrated a large expansile mass replacing the medial segment and caudate lobe with diffusely scattered nodules in the entire liver. The large hilar mass contained a central nonenhancing area and had a mass effect, leading to left portal vein occlusion. The image findings also revealed two unprecedented findings: left lateral segmental atrophy of the liver and recent portomesenteric vein thrombosis. The hepatic lesions were confirmed with hemangiomas by ultrasonography-guided biopsy. We diagnosed intrahepatic portal vein obstruction caused by a mass effect of giant hepatic hemangioma coexistent with diffuse hemangiomatosis, resulting in hepatic segmental atrophy and extrahepatic portal vein thrombosis. PMID:24936497

  3. Hepatic hemangioma: dynamic bolus CT.

    PubMed

    Freeny, P C; Marks, W M

    1986-10-01

    Forty-seven patients with 58 hepatic hemangiomas were studied prospectively with a dynamic bolus CT protocol (single-level or incremental scans) that included precontrast scans, rapid-sequence scanning during the IV bolus injection of 150 ml of 60% contrast agent, and delayed scans taken as long as 60 min after contrast. Three CT criteria are believed to be necessary to make a specific diagnosis of hemangioma: lesion with diminished attenuation on precontrast scan; peripheral contrast enhancement during the dynamic bolus phase of scanning; and complete isodense fill-in on delayed scans obtained up to 60 min after contrast. These CT criteria were seen in only 32 (55%) of 58 hemangiomas, making CT a relatively poor imaging technique for diagnosis. PMID:3489370

  4. [Hepatic hemangioma: the choice of treatment].

    PubMed

    Aksenov, I V; Fedorchenko, A N

    2010-01-01

    117 patients with hepatic hemangioma were treated. 17 patients were operated on with the use of laser and plasmic scalpel. The possibility and technical features of liver resections by hepatic hemangiomas are discussed. In 8 of 17 operated patients, endovascular hemangiomatous vessel occlusion was effective. Authors state the necessity of reduction of surgical treatment of hepatic hemangiomas and substantiate the need of dynamic observation of such lesions of the liver. PMID:20559223

  5. Giant cavernous hemangiomas: report of three cases

    Microsoft Academic Search

    E. J. van Lindert; T. C. Tan; J. A. Grotenhuis; P. Wesseling

    2007-01-01

    Giant cavernous hemangiomas occur very rarely, and little has been reported about their behavior. In this case report three cavernous hemangiomas with a diametric measure between 6 cm and 7 cm and distinct features will be described. A 36-year-old female patient presented with headache and nausea. A CT scan disclosed a large circumscribed tumor with strong contrast enhancement in the temporo-parieto-occipital region

  6. Differentiation of Hepatic Metastases from Hepatic Hemangiomas and Cysts by Using MR Imaging

    Microsoft Academic Search

    Jack Wittenberg; David D. Stark; Bruce H. Forman; Peter F. Hahn; Sanjay Saini; Ralph Weissleder; Ernst Rumrneny; Joseph T. Ferrucci

    Ti-weighted and T2-weighted pulse sequences were employed for MR imaging of hepatic metastatic tumors (98 patients), hemangiomas (24 patients), and cysts (seven patients); a 0.6-T superconducting magnet was used. In a retrospective study, signal intensity and morphology were used to establish criteria for differentiating metastases from hemangiomas and cysts. The signal intensity of the lesion alone failed to be an

  7. Transcatheter arterial chemoembolization in patients with hepatocellular carcinoma and coexisting hepatic cavernous hemangioma

    Microsoft Academic Search

    Ran-Chou Chen; Jiunn-Ming Lii; Wei-Tsung Chen; Hsing-Yang Tu; Liang-Chung Chiang

    2006-01-01

    We investigated the consequence of repeated transcatheter arterial chemoembolization (TACE) for coexisting small hepatic hemangioma\\u000a in the treatment of patients with hepatocellular carcinomas and describe the imaging features of embolized hemangioma on the\\u000a follow-up Lipiodol CT and MR. Six of 431 patients with biopsy-confirmed hepatocellular carcinomas, who underwent TACE, also\\u000a had seven small hepatic cavernous hemangiomas (0.8?2.3 cm) in the same

  8. Increased type 3 iodothyronine deiodinase activity in a regrown hepatic hemangioma with consumptive hypothyroidism

    Microsoft Academic Search

    Kazuhiko Bessho; Yuri Etani; Hiroaki Ichimori; Yoko Miyoshi; Noriyuki Namba; Akihiro Yoneda; Takaharu Ooue; Tsuyoshi Chihara; Eiichi Morii; Tomoyuki Aoki; Masami Murakami; Sotaro Mushiake; Keiichi Ozono

    2010-01-01

    Introduction  Infantile hepatic hemangioma with consumptive hypothyroidism is a rare condition.\\u000a \\u000a \\u000a \\u000a Case report  A 4-month-old girl presented with diffuse hepatic hemangiomas during treatment of congenital hypothyroidism. Serum reverse\\u000a triiodothyronine was elevated, and her hypothyroidism improved concomitant with involution of the hemangioma following prednisolone\\u000a and interferon-? administration. At 20 months of age, 7 months after discontinuing prednisolone and interferon-?, a focal\\u000a hemangioma regrew from one

  9. Transcatheter arterial chemoembolization in patients with hepatocellular carcinoma and coexisting hepatic cavernous hemangioma.

    PubMed

    Chen, Ran-Chou; Lii, Jiunn-Ming; Chen, Wei-Tsung; Tu, Hsing-Yang; Chiang, Liang-Chung

    2006-06-01

    We investigated the consequence of repeated transcatheter arterial chemoembolization (TACE) for coexisting small hepatic hemangioma in the treatment of patients with hepatocellular carcinomas and describe the imaging features of embolized hemangioma on the follow-up Lipiodol CT and MR. Six of 431 patients with biopsy-confirmed hepatocellular carcinomas, who underwent TACE, also had seven small hepatic cavernous hemangiomas (0.8 approximately 2.3 cm) in the same area of embolization. All six patients underwent repeated TACE All lesions were evaluated with CT and/or MR for the post-treatment follow-up. The outcomes and imaging features of these embolized hemangiomas were reviewed for the change of tumor size, Lipiodol deposition, enhancing pattern as well as embolization complications. Six of the seven hemangiomas did not depict changes in the size or enhancement pattern without being ablated. One hemangioma showed a decrease in size, but still persisted after TACE. All of the hemangiomas showed Lipiodol deposition for 2 approximately 15 months, in which five hemangiomas depicted irregular rim patterns. There is no complication caused by the procedures. The differentiation of small hepatic hemangiomas from viable HCC is important in the post-TACE follow-up to avoid unnecessary repeated embolization. PMID:16331460

  10. Rapidly enhancing hepatic hemangiomas at MRI: distinction from malignancies with T2-weighted images.

    PubMed

    Outwater, E K; Ito, K; Siegelman, E; Martin, C E; Bhatia, M; Mitchell, D G

    1997-01-01

    The purpose of this study is to describe a subset of atypical hepatic hemangiomas that enhance rapidly and diffusely and to determine whether heavily T2-weighted images could distinguish between atypically enhancing liver hemangiomas and hypervascular malignancies. A retrospective search of MR records identified seven patients with liver hemangiomas that demonstrated diffuse early enhancement and 23 patients with biopsy-proven malignant liver lesions that were hypervascular on dynamic gadolinium-enhanced MR images. Quantitative analysis of signal intensity measurements was performed on the T2-weighted images, heavily T2-weighted (TE > 140), and dynamic gadolinium-enhanced images. Blinded reader comparison of the T2-weighted images and gadolinium-enhanced images was performed. Hypervascular hemangiomas enhanced to a greater degree than hypervascular malignant liver lesions on the early phase gadolinium-enhanced images. Perilesional parenchymal enhancement was demonstrated in five cases of rapidly enhancing hemangiomas. Signal intensity and contrast-to-noise ratios on the heavily T2-weighted images of the hemangiomas were significantly greater than that of the hypervascular malignant lesions (P < .05). Hemangiomas were differentiated from the hypervascular malignant liver lesions with high accuracy (97-100%) by three blinded readers based on the T2-weighted images. A subset of hemangiomas have atypical rapid diffuse enhancement on dynamic gadolinium-enhanced images. These atypical hemangiomas can be distinguished from hypervascular malignant liver lesions on T2-weighted MR images. PMID:9400846

  11. Acoustic Radiation Force Impulse Elastography for Focal Hepatic Tumors: Usefulness for Differentiating Hemangiomas from Malignant Tumors

    PubMed Central

    Kim, Ji Eun; Bae, Kyung Soo; Han, Joon Koo; Choi, Byung Ihn

    2013-01-01

    Objective The purpose of this study is to investigate whether acoustic radiation force impulse (ARFI) elastography with ARFI quantification and ARFI 2-dimensional (2D) imaging is useful for differentiating hepatic hemangiomas from malignant hepatic tumors. Materials and Methods One-hundred-and-one tumors in 74 patients were included in this study: 28 hemangiomas, 26 hepatocellular carcinomas (HCCs), three cholangiocarcinomas (CCCs), 20 colon cancer metastases and 24 other metastases. B-mode ultrasound, ARFI 2D imaging, and ARFI quantification were performed in all tumors. Shear wave velocities (SWVs) of the tumors and the adjacent liver and their SWV differences were compared among the tumor groups. The ARFI 2D images were compared with B-mode images regarding the stiffness, conspicuity and size of the tumors. Results The mean SWV of the hemangiomas was significantly lower than the malignant hepatic tumor groups: hemangiomas, 1.80 ± 0.57 m/sec; HCCs, 2.66 ± 0.94 m/sec; CCCs, 3.27 ± 0.64 m/sec; colon cancer metastases, 3.70 ± 0.61 m/sec; and other metastases, 2.82 ± 0.96 m/sec (p < 0.05). The area under the receiver operating characteristics curve of SWV for differentiating hemangiomas from malignant tumors was 0.86, with a sensitivity of 96.4% and a specificity of 65.8% at a cut-off value of 2.73 m/sec (p < 0.05). In the ARFI 2D images, the malignant tumors except HCCs were stiffer and more conspicuous as compared with the hemangiomas (p < 0.05). Conclusion ARFI elastography with ARFI quantification and ARFI 2D imaging may be useful for differentiating hepatic hemangiomas from malignant hepatic tumors. PMID:24043967

  12. Laparoscopic vs computerized tomography-guided radiofrequency ablation for large hepatic hemangiomas abutting the diaphragm

    PubMed Central

    Gao, Jun; Kong, Jian; Ding, Xue-Mei; Ke, Shan; Niu, Hai-Gang; Xin, Zong-Hai; Ning, Chun-Min; Guo, Shi-Gang; Li, Xiao-Long; Zhang, Long; Dong, Yong-Hong; Sun, Wen-Bing

    2015-01-01

    AIM: To compare safety and therapeutic efficacy of laparoscopic radiofrequency (RF) ablation vs computed tomography (CT)-guided RF ablation for large hepatic hemangiomas abutting the diaphragm. METHODS: We retrospectively reviewed our sequential experience of treating 51 large hepatic hemangiomas abutting the diaphragm in 51 patients by CT-guided or laparoscopic RF ablation due to either the presence of symptoms and/or the enlargement of hemangioma. Altogether, 24 hemangiomas were ablated via a CT-guided percutaneous approach (CT-guided ablation group), and 27 hemangiomas were treated via a laparoscopic approach (laparoscopic ablation group). RESULTS: The mean diameter of the 51 hemangiomas was 9.6 ± 1.8 cm (range, 6.0-12.0 cm). There was no difference in the diameter of hemangiomas between the two groups (P > 0.05). RF ablation was performed successfully in all patients. There was no difference in ablation times between groups (P > 0.05). There were 23 thoracic complications in 17 patients: 15 (62.5%, 15/24) in the CT-guided ablation group and 2 (7.4%, 2/27) in the laparoscopic ablation group (P < 0.05). According to the Dindo-Clavien classification, two complications (pleural effusion and diaphragmatic rupture grade III) were major in two patients. All others were minor (grade?I). Both major complications occurred in the CT-guided ablation group. The minor complications were treated successfully with conservative measures, and the two major complications underwent treatment by chest tube drainage and thoracoscopic surgery, respectively. Complete ablation was achieved in 91.7% (22/24) and 96.3% (26/27) in the CT-guided and the laparoscopic ablation groups, respectively (P > 0.05). CONCLUSION: Laparoscopic RF ablation therapy should be used as the first-line treatment option for large hepatic hemangiomas abutting the diaphragm. It avoids thermal injury to the diaphragm and reduces thoracic complications. PMID:26019459

  13. Iodized-oil retention within hepatic hemangioma: characteristics on iodized-oil CT

    Microsoft Academic Search

    W. K. Moon; B. I. Choi; J. K. Han; S. H. Kim; J. W. Chung; J. H. Park; M. C. Han

    1996-01-01

    Objective: The purpose of this study was to describe the characteristic computed tomographic (CT) appearance of iodized-oil retention\\u000a in hepatic hemangioma and to evaluate the duration of the retention of iodized oil on follow-up CT.\\u000a \\u000a \\u000a Methods: Seventeen hepatic hemangiomas of 14 patients were studied with CT performed 1–3 weeks after injection of 2–9 ml of iodized\\u000a oil (iodized-oil CT) for

  14. Perfusion characteristics of hepatic cavernous hemangioma using intravenous CT angiography (IVCTA).

    PubMed

    Gaa, J; Saini, S; Ferrucci, J T

    1991-01-01

    Thirty-three patients with 35 proven hepatic cavernous hemangiomas (HCH) were studied with intravenous CT angiography (IVCTA). 15 scans were performed during the first 30 s after bolus (6 ml/s) injection of 50 ml iodinated contrast material. Thereafter 2 scans/min were obtained up to 30 min. Three criteria were utilized at IVCTA to make a specific diagnosis of HCH: (1) detection of an intense mural nodular enhancement in the arterial phase. The density in the nodular region(s) should have a density level similar to that of the aorta or hepatic arteries; (2) well-defined nodular area(s); and (3) centripetally oriented enlargement of the nodular region(s). These criteria were seen in 31 of 35 hemangiomas. In contrast the 'typical' Freeny-Marks criteria were present in only 23 of 35 hemangiomas. The results show that our criteria may provide greater specificity. PMID:1855518

  15. Magnetic resonance imaging of a small vessel hepatic hemangioma in a cirrhotic patient with histopathologic correlation.

    PubMed

    Lewis, Sara; Aljarallah, Badr; Trivedi, Anshu; Thung, Swan N

    2015-01-01

    The authors report and discuss a rare case of a small vessel hepatic hemangioma in a 59-year-old patient with liver cirrhosis, which was pre-procedurally characterized as indeterminate due to atypical magnetic resonance imaging (MRI) features. This manuscript reviews the MRI features with pathologic correlation, emphasizes the importance of accurate characterization of liver lesions, and discusses the role of biopsy. We believe this is the first reported case of a small vessel hemangioma in liver cirrhosis with imaging and histopathologic correlation. PMID:25748474

  16. Laparoscopic resection of giant liver hemangioma using laparoscopic Habib probe for parenchymal transection

    PubMed Central

    Gadiyaram, Srikanth; Shetty, Neel

    2012-01-01

    Experience with laparoscopic liver resections is limited. Laparoscopic resection of a variety of liver lesions has been reported and is considered appropriate for lesions in the left lateral segment and inferior segments of the right lobe. Herein, we report a 52-year-old male patient who underwent a laparoscopic resection of giant liver hemangioma with the use of a laparoscopic 4× Habib probe. PMID:22623829

  17. Hepatocellular carcinoma with concomitant hepatic angiomyolipoma and cavernous hemangioma in one patient

    PubMed Central

    Ge, Xiao-Wen; Zeng, Hai-Ying; Su-Jie, Akesu; Du, Min; Ji, Yuan; Tan, Yun-Shan; Hou, Ying-Yong; Xu, Jian-Fang

    2015-01-01

    The risk of developing hepatocellular carcinoma (HCC) is strongly associated with hepatitis B virus infection. Hepatic angiomyolipoma (AML), a rare benign tumor, is composed of a heterogeneous mixture of adipose cells, smooth muscle cells and blood vessels. Here, we report the case of a 44-year-old man who developed HCC with a concomitant hepatic AML and a cavernous hemangioma, in the absence of cirrhosis. To our knowledge, based on an extensive literature search using the www.pubmed.gov website, this is the first report of an HCC case with both concomitant AML and cavernous hemangioma at the same position in the liver. The presence of the hepatitis B surface antigen was detected, but the liver function was normal. Clinical and pathological data were collected before and during the treatment. Hepatic AML was diagnosed based on the typical histological characteristics and immunohistochemical staining, which revealed, a positive staining with a melanocytic cell-specific monoclonal antibody. There was no evidence of tuberous sclerosis complex in this patient. Although the HCC was poor- to moderately-differentiated, the characteristics of the AML and the cavernous hemangioma in this patient did not match any criteria for malignancy. Hepatectomy followed by transarterial chemoembolization treatment were effective therapeutic methods for the adjacent lesions in this patient. This case is an interesting coincidence. PMID:25805953

  18. [Anesthetic management of a patient with Sturge-Weber syndrome associated with a giant facial hemangioma].

    PubMed

    Fujii, Noriko; Usuda, Iwao; Hikawa, Yoshio

    2014-06-01

    A 32-year old man with Sturge-Weber syndrome, a rare congenital disease of multiple angiomatous lesions including cervical cortex, face, oral soft tissues, larynx and trachea, underwent the excision of a back lipoma. His hemangioma which extended into the region of the right ophthalmic nerve and superior maxillary nerve is extremely large. He also had mental retardation and epilepsy. No apparent hemangioma was found in his oral cavity, pharynxes, larynx and trachea by preoperative exam. His hemangioma made it difficult to cover his mouth and nose by usual face mask. Though we first considered awake intubation, he was difficult to obey our command. So we searched for the face mask covering his nose and mouth without pressing his facial angioma. Finally, we discovered the full-face mask for NIPPV. After induction with propofol, we confirmed the perfect mask fit, and ventilation by two-person method was effective. Then we administered rocuronium and fentanyl, and intubated without difficulty. The patient was maintained by sevoflurane. He was hemodynamically stable. He was extubated without bleeding and respiratory problems. We experienced general anesthesia of a patient with Sturge-Weber syndrome who had a giant facial hemangioma. With full-face NIPPV mask we safely induced general anesthesia. PMID:24979867

  19. Interventional Treatment of a Symptomatic Neonatal Hepatic Cavernous Hemangioma Using the Amplatzer Vascular Plug

    SciTech Connect

    Kretschmar, Oliver, E-mail: oliver.kretschmar@kispi.unizh.ch; Knirsch, Walter [University Children's Hospital Zurich, Division of Pediatric Cardiology (Switzerland); Bernet, Vera [University Children's Hospital Zurich, Division of Neonatology and Pediatric Intensive Care (Switzerland)

    2008-03-15

    Percutaneous intervention is one treatment option for symptomatic hepatic hemangioma in infants. We report the case of a newborn (birth weight 4060 g) with a large hepatic cavernous hemangioma, which presented early with high cardiac output failure due to arteriovenous shunting and signs of incipient Kasabach-Merritt syndrome. We performed a successful superselective transcatheter coil embolization of three feeding arteries on the seventh day of life. Because of remaining diffuse very small arteries causing a relevant residual shunt, additional occlusion of the three main draining veins was necessary with three Amplatzer vascular plugs. Cardiac failure resolved immediately. Without any additional therapy the large venous cavities disappeared within the following months. The tumor continues to regress in size 8 months after the intervention.

  20. MR findings of hepatic cavernous hemangioma after intraarterial infusion of iodized oil

    Microsoft Academic Search

    B. I. Choi; Y. M. Shin; J. W. Chung; S. H. Kim; J. H. Park; M. C. Han

    1994-01-01

    Magnetic resonance (MR) imaging was performed on five tumors of three patients who had hepatic hemangiomas. Four tumors were given an intraarterial infusion of 3–8 ml of iodized oil, while one tumor was not. MR images were obtained at 2.0 or 0.5 T. A single spin echo sequence with TE of 30 ms and TR of 500 ms and a

  1. Ferucarbotran-enhanced T2-weighted magnetic resonance imaging: differentiation of hepatic cavernous hemangiomas from malignant solid lesions

    Microsoft Academic Search

    Eun-Suk Cho; Jeong-Sik Yu; Jhii-Hyun Ahn; Mi-Suk Park; Joo Hee Kim; Jae-Joon Chung; Ki Whang Kim

    2009-01-01

    Background  To demonstrate the characteristic feature of hepatic cavernous hemangiomas on ferucarbotran-enhanced T2-weighted MR imaging\\u000a as a new diagnostic finding.\\u000a \\u000a \\u000a \\u000a Methods  In 201 hepatic lesions (61 hemangiomas, 61 cysts, 41 hepatocellular carcinomas, 31 metastatic carcinomas, and 7 cholangiocarcinomas),\\u000a lesion-to-liver contrast on ferucarbotran-enhanced T2-weighted images was qualitatively compared with pre-contrast images\\u000a by three independent readers using a four-grade scale (group 1, marked increase;

  2. Transcatheter arterial embolization of two symptomatic giant cavernous hemangiomas of the liver.

    PubMed

    Althaus, S; Ashdown, B; Coldwell, D; Helton, W S; Freeny, P C

    1996-01-01

    Cavernous hemangiomas are usually asymptomatic; however, a small percentage may cause symptoms. This case report discusses palliation by transcatheter arterial embolization with polyvinyl alcohol particles. PMID:8781162

  3. Transcatheter Arterial Embolization of Two Symptomatic Giant Cavernous Hemangiomas of the Liver

    Microsoft Academic Search

    Sandra Althaus; Boyd Ashdown; Douglas Coldwell; W. Scott Helton; Patrick C. Freeny

    1996-01-01

    Cavernous hemangiomas are usually asymptomatic; however, a small percentage may cause symptoms. This case report discusses palliation by transcatheter arterial embolization with polyvinyl alcohol particles.

  4. Transcatheter Arterial Embolization of Two Symptomatic Giant Cavernous Hemangiomas of the Liver

    SciTech Connect

    Althaus, Sandra; Ashdown, Boyd [Department of Radiology, Box 357115, University of Washington School of Medicine, 1959 NE Pacific Street, Seattle, WA 98195 (United States); Coldwell, Douglas [Department of Radiology, Denver General Hospital, 303 Bannock Street, Denver, CO 80204-4507 (United States); Helton, W. Scott [Department of General Surgery, University of Washington School of Medicine, 1959 NE Pacific Street, Seattle, WA 98195 (United States); Freeny, Patrick C. [Department of Radiology, Box 357115, University of Washington School of Medicine, 1959 NE Pacific Street, Seattle, WA 98195 (United States)

    1996-09-15

    Cavernous hemangiomas are usually asymptomatic; however, a small percentage may cause symptoms. This case report discusses palliation by transcatheter arterial embolization with polyvinyl alcohol particles.

  5. Transcatheter arterial embolization of two symptomatic giant cavernous hemangiomas of the liver

    Microsoft Academic Search

    Sandra Althaus; Boyd Ashdown; Douglas Coldwell; W. Scott Helton; Patrick C. Freeny

    1996-01-01

    Cavernous hemangiomas are usually asymptomatic; however, a small percetage may cause symptoms. This case report discusses\\u000a palliation by transcatheter arterial embolization with polyvinyl alcohol particles.

  6. Morphologic, Phenotypic and Functional Characteristics of Endothelial Cells Derived from Human Hepatic Cavernous Hemangioma

    Microsoft Academic Search

    Wen-jian Zhang; Li-ya Ye; Lian-qiu Wu; Yu-ling Xin; Feng Gu; Ji-xiao Niu; Zhi-hua Yang; Guang-jin Zhu; Georges E. Grau; Jin-ning Lou

    2006-01-01

    Backgrounds\\/Aims: The pathogenesis of cavernous hemangiomas is largely unknown, and it is speculated that abnormal vasculogenesis and angiogenesis may be involved. In this study, the characteristics of cavernous hemangioma endothelial cells (CHECs) derived from the human liver were analyzed in terms of morphology, phenotype and function and compared with human liver sinusoidal endothelial cells (LSECs). Methods and Results: By transmission

  7. Cherry Hemangioma

    MedlinePLUS

    newsletter | contact Share | Cherry Hemangioma Information for adults A A A The small, red bumps of cherry hemangiomas can be widespread and vary in size, as in this adult. As a general rule, cherry hemangiomas do not become much larger than an ...

  8. Sclerosed Hemangioma Accompanied by Multiple Cavernous Hemangiomas of the Liver

    PubMed Central

    Yuki, Michiko; Emoto, Yuko; Kinoshita, Yuichi; Yoshizawa, Katsuhiko; Yuri, Takashi; Tsubura, Airo

    2015-01-01

    Patient: Male, 81 Final Diagnosis: Sclerosed hemangioma Symptoms: — Medication: — Clinical Procedure: Autopsy Specialty: Diagnostics, Laboratory Objective: Rare disease Background: A sclerosed hemangioma of the liver, an extremely rare type of benign hepatic tumor, was found at autopsy. Case Report: An 81-year-old Japanese man was admitted to our hospital for surgical resection of squamous cell carcinoma of the skin in his left forearm. At admission, serological tests for hepatitis B surface antigen and hepatitis C antibody were negative with no evidence of cirrhosis. At 2, 3, and 5 months after the removal of the forearm tumor, skin grafting was performed because of unhealed skin ulceration. Although anti-bacterial drugs were prescribed, the patient died after the 3rd skin graft (5 months after the surgery) because of pneumonia. During the treatment course, the patient was diagnosed as having multiple liver masses suspected to be cysts of the liver based on non-contrasted computed tomography results. Autopsy revealed a sclerosed hemangioma occupying the entire left lobe accompanied by multiple small cavernous hemangiomas in the right lobe of the liver. Conclusions: Sclerosed hemangioma, a rare benign disease, occurred in association with degeneration and sclerosis of cavernous hemangiomas of the liver. The VEGF pathway may be involved in the genesis of cavernous and sclerosed hemangioma of the liver. PMID:26116763

  9. Liver transplant for giant cell hepatitis with autoimmune haemolytic anaemia

    PubMed Central

    Melendez, H. V.; Rela, M.; Baker, A.; Ball, C.; Portmann, B.; Mieli-Vergani, G.; Heaton, N.

    1997-01-01

    ?? Giant cell hepatitis (CGH) with autoimmune haemolytic anaemia (AHA) is a distinct entity with an aggressive course. Immunosuppression may help early disease. A case is reported of a child with GCH and AHA with early disease recurrence after liver transplantation for end stage liver disease. ?? PMID:9370907

  10. Sclerosed Hemangioma Accompanied by Multiple Cavernous Hemangiomas of the Liver.

    PubMed

    Yuki, Michiko; Emoto, Yuko; Kinoshita, Yuichi; Yoshizawa, Katsuhiko; Yuri, Takashi; Tsubura, Airo

    2015-01-01

    BACKGROUND A sclerosed hemangioma of the liver, an extremely rare type of benign hepatic tumor, was found at autopsy. CASE REPORT An 81-year-old Japanese man was admitted to our hospital for surgical resection of squamous cell carcinoma of the skin in his left forearm. At admission, serological tests for hepatitis B surface antigen and hepatitis C antibody were negative with no evidence of cirrhosis. At 2, 3, and 5 months after the removal of the forearm tumor, skin grafting was performed because of unhealed skin ulceration. Although anti-bacterial drugs were prescribed, the patient died after the 3rd skin graft (5 months after the surgery) because of pneumonia. During the treatment course, the patient was diagnosed as having multiple liver masses suspected to be cysts of the liver based on non-contrasted computed tomography results. Autopsy revealed a sclerosed hemangioma occupying the entire left lobe accompanied by multiple small cavernous hemangiomas in the right lobe of the liver. CONCLUSIONS Sclerosed hemangioma, a rare benign disease, occurred in association with degeneration and sclerosis of cavernous hemangiomas of the liver. The VEGF pathway may be involved in the genesis of cavernous and sclerosed hemangioma of the liver. PMID:26116763

  11. Frequency of Arteriovenous Shunts in Hepatic Cavernous Hemangiomas in Adults as Seen on Selective Arteriography and Postembolization Radiography

    SciTech Connect

    Ouyang Yong; Ouyang Xuehui; Yu Ming; Gu Shubin [Department of Interventional Radiology, Inner Mongolia Autonomous Region's Hospital, Huhehaote 010017 (China)

    2001-05-15

    Purpose: To study the frequency and angiographic findings of arteriovenous shunts (AVS) associated with adult cavernous hemangiomas of the liver (CHL) on hepatic artery digital subtraction angiography (DSA) and optimize the imaging technique of DSA to improve its diagnostic efficacy.Methods: We retrospectively analyzed 43 intraarterial DSA procedures performed on 30 adults with CHL. Of the 30 patients 22 were found to have an AVS. Transcatheter arterial embolization with Lipiodol (L-TAE) was performed on 21 of these and radiographs were taken immediately after embolization to observe the distribution of the injected iodized oil. The results were compared with those of the AVS found on DSA images.Results: AVS were identified by DSA in 22 (73.3%) of 30 patients. All AVS were located in the peritumoral liver tissue and had a parallel track appearance, or early filling of small draining veins during the arterial phase of DSA. Radiographs taken immediately after L-TAE in 21 of the 22 cases with AVS showed iodized oil filling a few portal branches or draining veins as a result of incompletely occluded shunts in 11 patients. In 10 patients there was complete occlusion and no filling of any vein, or only the originating end of draining veins filled with iodized oil. No evidence of AVS was found in the other eight patients in this series, and in six of these the DSA was not considered diagnostic.Conclusion: The present study indicates that AVS are frequently seen in adults with CHL. DSA with high-quality images is helpful in identifying small AVS of CHL. The formation of an AVS in CHL may be closely related to the pathological changes in the peritumoral liver tissue.

  12. Giant hepatic angiomyolipoma simulating focal nodular hyperplasia

    Microsoft Academic Search

    Masaki Miyahara; Michio Kobayashi; Izuru Tada; Kazunari Okada; Koichi Sato; Yang Kim; Tadayasu Hiraoka; Shigeo Yokoyama

    1988-01-01

    A case of hepatic angiomyolipoma occurring in a 41-year-old woman, the eighteenth case in literature, is reported herein.\\u000a The radiographic imagings of the tumor simulated those of focal nodular hyperplasia; namely, the tumor was hyperechoic on\\u000a ultrasound, hypodense on computed tomography, hypervascular on angiography, and exhibited an uptake of technetium (Tc)-99m\\u000a phytate. The diagnosis was established after successful removal of

  13. Management of giant hepatic cysts in the laparoscopic era

    PubMed Central

    Choi, Chan Joong; Roh, Young Hoon; Jung, Ghap Joong; Seo, Jeong Wook; Baek, Yang Hyun; Lee, Sung Wook; Roh, Myung Hwan; Han, San Young; Jeong, Jin Sook

    2013-01-01

    Purpose We sought to evaluate the feasibility and outcomes of laparoscopic resection of giant hepatic cysts and surgical success, focusing on cyst recurrence. Methods From February 2004 to August 2011, 37 consecutive patients with symptomatic hepatic cysts were evaluated and treated at Dong-A University Hospital. Indications were simple cysts (n = 20), multiple cysts (n = 6), polycystic disease (n = 2), and cystadenoma (n = 9). Results The median patient age was 64 years, with a mean lesion diameter of 11.4 cm. The coincidence between preoperative imaging and final pathologic diagnosis was 54% and half (n = 19) of the cysts were located in segments VII and VIII. Twenty-two patients had American Society of Anesthesiologists (ASA) classification I and II, and nine had ASA classification III. Surgical treatment of hepatic cysts were open liver resection (n = 3), laparoscopic deroofing (n = 24), laparoscopic cyst excision (n = 4), laparoscopic left lateral sectionectomy (n = 2), hand assisted laparoscopic procedure (n = 2), and single port laparoscopic deroofing (n = 2). The mean fellow-up was 21 months, and six patients (16%) experienced radiographic-apparent recurrence. Reoperation due to recurrence was performed in two patients. Among the factors predicting recurrence, multivariate analysis revealed that interventional radiological procedures and pathologic diagnosis were statistically significant. Conclusion Laparoscopic resection of giant hepatic cysts is a simple and effective method to relieve symptoms with minimal surgical trauma. Moreover, the recurrence is dependent on the type of pathology involved, and the sclerotherapy undertaken. PMID:24020020

  14. [Giant simple hepatic cysts as dyspnea symptom in a 93-year-old patient].

    PubMed

    Macho Pérez, O; Gómez Pavón, J; Núñez González, A; Narvaiza Grau, L; Albéniz Aguiriano, L

    2007-03-01

    Giant simple hepatic cysts is generally asymptomatic in the 3% of cases of adult patients. We present a woman case of 93 years old who was diagnoses of giant simple hepatic cyst presented as dysnea. The management of this patient was with percutaneous aspiration and fenol alcohol. It made a review of cystic lesions of the liver and of simple hepatic cysts management. PMID:17590136

  15. Improved sonographic imaging of hepatic hemangioma with contrast-enhanced coded harmonic angiography: comparison with MR imaging

    Microsoft Academic Search

    Jae Young Lee; Byung Ihn Choi; Joon Koo Han; Ah Young Kim; Shang Hun Shin; Sung Gyu Moon

    2002-01-01

    The aim of this study was to compare peripheral nodular enhancement with centripetal progression on contrast-enhanced coded harmonic angio (CHA) with those as seen on magnetic resonance imaging (MRI) scan. A total of 20 patients with 24 hemangiomas confirmed by dynamic contrast-enhanced MRI were included in this study. All 20 patients were examined with CHA in conjunction with a galactose-based

  16. Hemangiomas of the liver in patients with renal cell carcinoma.

    PubMed

    Madayag, M A; Bosniak, M A; Kinkhabwala, M; Becker, J A

    1978-02-01

    Five patients with renal cell carcinoma were noted at angiography to have vascular hepatic lesions which resembled metastatic renal cell carcinoma but which proved to be benign hepatic hemangiomas. The angiographic differentiation between small hemangiomas and metastatic vascular neoplasms of the liver can be difficult; angiographic characteristics may not be definitive. Surgery to remove the renal tumor should not be deferred solely on the basis of vascular hepatic lesions found at angiography. PMID:622488

  17. [Hemangioma: complications].

    PubMed

    Casanova, D; Norat, F; Bardot, J; Magalon, G

    2006-01-01

    Hemangioma (HMG) is a benign tumour of the child generally evolving to spontaneous regression. Sometimes this evolution can become complicated in a more or less serious way according to its localization or of its importance. If local complications are, in the most of cases, without gravity, complications of a general nature like thrombopenia or cardiac failure may compromise the vital prognosis. There are in addition serious forms where, according to its localization or its importance, the HMG can compromise the aesthetic, or functional even vital outcome. PMID:16997443

  18. Hemorrhagic hemangioma in the liver: A case report

    PubMed Central

    Kim, Jeong Min; Chung, Woo Jin; Jang, Byoung Kuk; Hwang, Jae Seok; Kim, Yong Hoon; Kwon, Jung Hyeok; Choi, Mi Sun

    2015-01-01

    Hemangioma is the most common type of benign tumor that arises in the liver. Although rupture and hemorrhage of hepatic hemangioma are rare complications, they can be the cause of mortality. The authors report a case of hemorrhagic hepatic hemangioma: in a 54-year-old woman who was admitted with epigastric pain. She had taken oral contraceptives several weeks prior. The results of a blood examination were normal. An abdominal computed tomography scan revealed a tumor in hepatic segment 4, and a hemorrhage inside the cystic mass was suspected. The mass was removed laparoscopically to confirm the tumor properties and control the hemorrhage. The pathologic findings of the resected mass were consistent with hepatic hemangioma with intratumoral hemorrhage. The patient was discharged 8 d after the surgery, without further complications or complaints, and the patient’s condition was found to have improved during follow-up.

  19. Birthmarks and Hemangiomas

    MedlinePLUS

    ... of hemangioma is left untreated, few complications or cosmetic problems result. At times, hemangiomas may need to ... successful in many cases, but other types of surgery are rarely recommended. Last Updated 5/5/2015 ...

  20. Giant Hepatic Carcinoid: A Rare Tumor with a Favorable Prognosis

    PubMed Central

    Elens, Maxime; Vrancken, Celine; Nuytens, Frederiek; Meert, Thibault; Delugeau, Veronique

    2014-01-01

    Primary hepatic carcinoids are rare tumors that are often diagnosed at a locally advanced stage. Their primary nature can only be ascertained after thorough investigations and long-term follow-up to exclude another primary origin. As with secondary neuroendocrine liver tumors, surgical resection remains the mainstay of therapy. Despite their large size and often central location liver resection is often feasible, offering long-term survival and cure to most patients. In selected patients liver transplantation appears to be a good indication for tumors not amenable to liver resection. An aggressive surgical attitude is therefore warranted. We report a large and unusually fast-growing liver carcinoid that appeared only marginally resectable in a patient who remains free of disease four years after surgery. PMID:24653852

  1. What Is Hemangioma?

    MedlinePLUS

    ... to Z Age-related Macular Degeneration (AMD) Allergies Amblyopia (Lazy Eye) Astigmatism Bacterial Keratitis Bell's Palsy Blepharitis ... eye and possibly lead to vision problems, including amblyopia and glaucoma . Hemangiomas gradually disappear over time. Half ...

  2. Sector iris hemangioma in association with diffuse choroidal hemangioma.

    PubMed

    Shields, Carol L; Atalay, Hatice Tuba; Wuthisiri, Wadakarn; Levin, Alex V; Lally, Sara E; Shields, Jerry A

    2015-02-01

    Two patients referred for iris lesions were found to have sector hemangioma of the iris stroma in contiguity with diffuse choroidal hemangioma. Neither patient had other manifestations of Sturge-Weber syndrome. PMID:25727597

  3. Unusual Severe Complication Following Transarterial Chemoembolization for Metastatic Malignant Melanoma: Giant Intrahepatic Cyst and Fatal Hepatic Failure

    SciTech Connect

    Ataergin, Selmin, E-mail: sataergin@superonline.co [GATA (Gulhane) Faculty of Medicine Gn. Dr. Tevfik Saglam caddesi, Department of Medical Oncology and Bone Marrow Transplantation Unit (Turkey); Tasar, Mustafa [GATA (Gulhane) Faculty of Medicine, Department of Radiology (Turkey); Solchaga, Luis [Case Western Reserve University, Department of Blood and Marrow Transplant, Ireland Cancer Center, University Hospitals Case Medical Center (United States); Ozet, Ahmet; Arpaci, Fikret [GATA (Gulhane) Faculty of Medicine Gn. Dr. Tevfik Saglam caddesi, Department of Medical Oncology and Bone Marrow Transplantation Unit (Turkey)

    2009-03-15

    We describe a 45-year-old male patient with malignant melanoma who underwent hepatic arterial chemoembolization due to liver metastases. Four months after the procedure, the patient developed a giant cystic cavity in the liver. Cytologic examination of the cystic fluid retention revealed necrotic tumor material. The fluid was drained by percutaneous catheter, but the patient developed hepatic failure. This case represents another rare complication of transarterial chemoembolization and shows that transarterial chemoembolization may have rare fatal complications.

  4. Propranolol (Infantile Hemangioma)

    MedlinePLUS

    Propranolol oral solution is used to treat proliferating infantile hemangioma (benign [noncancerous] growths or tumors appearing on or under the skin ... Propranolol comes as an oral solution (liquid) to take by mouth. ... is usually taken twice daily (9 hours apart) during or immediately after a ...

  5. Thoracic Extraosseous Epidural Cavernous Hemangioma

    PubMed Central

    Asil, Kiyasettin; Ceylan, Davut; Erdem, Sahin

    2015-01-01

    Cavernous hemangiomas were first reported in 1929 by Globus and Doshay, and are defined as benign vascular structures developed between the neural tissues occurring in the central nervous system, consisting of a dilated vascular bed. Cavernous hemangiomas comprise nearly 5-12% of all spinal vascular malformations; however, existence in the epidural space without bone involvement is rare. Only 4% of all cavernous hemangiomas (0.22/1.000.000) are purely epidural cavernous hemangiomas. In this case report, we removed a hemorrhagic thoracic mass presenting with progressive neurological deficits in a 55-year-old male patient. We found this case to be appropriate for presentation due to the rare occurrence of this type of cavernous hemangioma. PMID:25674348

  6. [Cutaneous hemangioma: clinical aspects].

    PubMed

    Casanova, D; Norat, F; Bardot, J; Magalon, G

    2006-01-01

    Infantile cutaneous hemangioma is a benign vascular tumour present at 10% of the infants. It forms part of the group of the vascular tumours in the classification of International Society for Vascular Anomalies (ISSVA). Clinical diagnosis is easy in its triphasic typical form with a phase of sometimes brutal postnatal growth, a phase of stabilization and a phase of slow secondary regression. Classically, it is presented in the form of a mass or stains cutaneous red, of a subcutaneous mass or, generally, of a mixed form associating the two aspects. PMID:16997447

  7. Epithelioid hemangioma of the orbit

    Microsoft Academic Search

    Todd M McEachren; Seymour Brownstein; David R Jordan; Vital A Montpetit

    2000-01-01

    ObjectiveTo describe the histopathologic features of two cases of epithelioid hemangioma occurring in the orbit and to distinguish this condition from Kimura’s disease and from other vascular lesions of proliferated endothelium.

  8. Hepatitis

    MedlinePLUS

    ... hepatitis B, although people who have had the hepatitis B vaccine are protected against it. In most cases, teens ... approved for use in adults. Although treatments for hepatitis B and C are becoming ... Vaccinated Vaccines can protect people against hepatitis A and hepatitis ...

  9. Hepatitis

    MedlinePLUS

    ... recommend an injection of immune (gamma) globulin. The hepatitis B vaccine is part of the recommended series of immunizations ... receive a total of 3 doses of the hepatitis B vaccine. Although there is no vaccine specifically for hepatitis ...

  10. Adult primary retroperitoneal cavernous hemangioma: a case report

    PubMed Central

    2012-01-01

    Primary retroperitoneal cavernous hemangioma (PRCH) in an adult is extremely rare. We report on the diagnosis and treatment of a patient with PRCH with subtle clinical features and atypical findings on imaging scans. A 38-year-old man was admitted to hospital with a 5-day history of epigastralgia after alcohol drinking. Using various imaging methods, we found a giant cyst-like retroperitoneal mass compressing the surrounding organs. Surgical resection of the tumor was performed, and the mass was found to be a cavernous hemangioma measuring 90 × 80 × 60 mm, with a thick fibrotic wall and extensive intracystic hemorrhage. Physicians should be aware that PRCH may mimic a cystic neoplasm, and that a large tumor size probably indicates intracystic hemorrhage. Surgical resection is a curative approach for PRCH. PMID:23216883

  11. Intramuscular hemangioma with phleboliths of the tongue.

    PubMed

    Kamatani, Takaaki; Saito, Tomoyuki; Hamada, Yoshiki; Kondo, Seiji; Shirota, Tatsuo; Shintani, Satoru

    2014-04-01

    Intramuscular hemangioma (IMH) is relatively rare benign tumor of vascular origin. Phleboliths are calcified thrombi found in the presence of hemangioma. The main treatment of the hemangioma is a surgical extirpation based on location, accessibility, and cosmetic considerations. We herein report a rare case of IMH with phleboliths of the tongue with clinical, imaging, and histopathological findings. PMID:25565734

  12. Large orbital hemangioma: managed with systemic propranolol.

    PubMed

    Puligadda, Ranjith K; Vijayalakshmi, B

    2014-08-01

    Most infantile hemangiomas resolve spontaneously without any need for therapy. However some hemangiomas require treatment to preserve function (vision, feeding and breathing) or to treat complications like ulceration, bleeding and scarring. The authors present a 5-mo-old infant with large orbital hemangioma on left side completely obscuring palpebral fissure, successfully managed with oral propranolol. PMID:24271877

  13. Patterns of contrast enhancement of benign and malignant hepatic neoplasms during bolus dynamic and delayed CT.

    PubMed

    Freeny, P C; Marks, W M

    1986-09-01

    Bolus dynamic and delayed computed tomographic (CT) scans of the liver were evaluated in 43 patients with 54 hepatic hemangiomas and 111 patients with primary or secondary malignant hepatic neoplasms. Twelve patterns of contrast enhancement were recognized during the bolus dynamic phase and delayed scanning. A "typical" CT pattern for hemangiomas (present in 29 of 54 hemangiomas [53.7%]) was established: (a) diminished attenuation prior to intravenous contrast medium administration (excluding lesions arising in a liver with diffuse fatty infiltration), (b) peripheral contrast enhancement during the bolus dynamic phase, and (c) complete isodense fill-in on delayed scan images. Using these criteria, we distinguished hemangiomas from malignant neoplasms in most patients. Only one of 63 (1.6%) malignant neoplasms manifested these typical CT criteria of hemangioma. There is an 86% chance that a lesion with the typical CT appearance of hemangioma is actually a hemangioma, even when found in a patient with a known nonhepatic primary neoplasm. PMID:3016794

  14. Pregnancy related symptomatic vertebral hemangioma

    PubMed Central

    Gupta, Meena; Nayak, Rajeev; Singh, Hukum; Khwaja, Geeta; Chowdhury, Debashish

    2014-01-01

    Vertebral hemangiomas are benign vascular tumors of the spine that remain asymptomatic in most cases and incidentally encountered on imaging. Rarely, altered hemodynamic and hormonal changes during pregnancy may expand these benign lesions resulting in severe cord compression. The management of symptomatic vertebral hemangioma during pregnancy is controversial as modalities like radiotherapy and embolization are not suitable and surgery during pregnancy has a risk of preterm labor. Few cases of pregnancy related symptomatic vertebral hemangioma with marked epidural component have been reported in the literature. We report a case of 23-year-old primigravida who developed rapidly progressive paraparesis at 28 weeks of gestation and spine magnetic resonance imaging (MRI) revealed upper thoracic vertebral hemangioma with extensive extra-osseous extension and spinal cord compression. Laminectomy and surgical decompression of the cord was performed at 32 weeks of the pregnancy. There was significant improvement in muscle power after a week of surgery. Six weeks postoperatively she delivered a full term normal baby with subsequent improvement of neurologic deficit. Repeat MRI of dorsal spine performed at 3 months postoperatively showed reduced posterior and anterior epidural components of vertebral hemangioma. PMID:24753678

  15. Hepatitis

    MedlinePLUS

    Dienstag JL. Hepatitis B virus infection. N Engl J Med . 2008;359:1486-1500. Jou JH, Muir AJ. In the clinic. Hepatitis C. Ann Intern Med . 2008;148:iTC6-1-ITC6-16. Sjogren MH, Cheatham JG. Hepatitis A. In: Feldman M, ...

  16. Biology of Infantile Hemangioma

    PubMed Central

    Itinteang, Tinte; Withers, Aaron H. J.; Davis, Paul F.; Tan, Swee T.

    2014-01-01

    Infantile hemangioma (IH), the most common tumor of infancy, is characterized by an initial proliferation during infancy followed by spontaneous involution over the next 5–10?years, often leaving a fibro-fatty residuum. IH is traditionally considered a tumor of the microvasculature. However, recent data show the critical role of stem cells in the biology of IH with emerging evidence suggesting an embryonic developmental anomaly due to aberrant proliferation and differentiation of a hemogenic endothelium with a neural crest phenotype that possesses the capacity for endothelial, hematopoietic, mesenchymal, and neuronal differentiation. Current evidence suggests a putative placental chorionic mesenchymal core cell embolic origin of IH during the first trimester. This review outlines the emerging role of stem cells and their interplay with the cytokine niche that promotes a post-natal environment conducive for vasculogenesis involving VEGFR-2 and its ligand VEGF-A and the IGF-2 ligand in promoting cellular proliferation, and the TRAIL-OPG anti-apoptotic pathway in preventing cellular apoptosis in IH. The discovery of the role of the renin–angiotensin system in the biology of IH provides a plausible explanation for the programed biologic behavior and the ?-blocker-induced accelerated involution of this enigmatic condition. This crucially involves the vasoactive peptide, angiotensin II, that promotes cellular proliferation in IH predominantly via its action on the ATIIR2 isoform. The role of the RAS in the biology of IH is further supported by the effect of captopril, an ACE inhibitor, in inducing accelerated involution of IH. The discovery of the critical role of RAS in IH represents a novel and fascinating paradigm shift in the understanding of human development, IH, and other tumors in general. PMID:25593962

  17. Vincristine for successful treatment of steroid-dependent infantile hemangiomas.

    PubMed

    Wasserman, Jonathan D; Mahant, Sanjay; Carcao, Manuel; Perlman, Kusiel; Pope, Elena

    2015-06-01

    Infantile hemangiomas (IHs) are common, although systemic therapy has been generally limited to circumstances of potential compromise of vital functions (airway, vision, feeding, or cardiac), risk of disfigurement, or bleeding. IHs have previously been shown to express high levels of type III deiodinase, which catabolizes active thyroid hormone, resulting in a state of severe hypothyroidism, termed "consumptive hypothyroidism." We describe an infant with diffuse hepatic hemangiomas who developed consumptive hypothyroidism who was initially treated successfully with systemic glucocorticoids and ?-blockers. Several efforts to wean her medications were unsuccessful. She subsequently developed severe growth restriction and treatment alternatives were sought. Although previously limited to treatment of life-threatening hemangiomas, a trial of vincristine was initiated. She was ultimately weaned from all systemic therapies, with recovery of a normal growth trajectory. This case highlights broader indications for vincristine as a safe and effective systemic therapy for treatment of IHs. It also stresses the importance of close anthropometric monitoring of infants and toddlers receiving glucocorticoid therapy and intervention when growth compromise becomes evident. PMID:25986022

  18. Dorsal spinal epidural cavernous hemangioma

    PubMed Central

    Sanghvi, Darshana; Munshi, Mihir; Kulkarni, Bijal; Kumar, Abhaya

    2010-01-01

    A 61-year-old female patient presented with diffuse pain in the dorsal region of the back of 3 months duration. The magnetic resonance imaging showed an extramedullary, extradural space occupative lesion on the right side of the spinal canal from D5 to D7 vertebral levels. The mass was well marginated and there was no bone involvement. Compression of the adjacent thecal sac was observed, with displacement to the left side. Radiological differential diagnosis included nerve sheath tumor and meningioma. The patient underwent D6 hemilaminectomy under general anesthesia. Intraoperatively, the tumor was purely extradural in location with mild extension into the right foramina. No attachment to the nerves or dura was found. Total excision of the extradural compressing mass was possible as there were preserved planes all around. Histopathology revealed cavernous hemangioma. As illustrated in our case, purely epidural hemangiomas, although uncommon, ought to be considered in the differential diagnosis of spinal epidural soft tissue masses. Findings that may help to differentiate this lesion from the ubiquitous disk prolapse, more common meningiomas and nerve sheath tumors are its ovoid shape, uniform T2 hyperintense signal and lack of anatomic connection with the neighboring intervertebral disk or the exiting nerve root. Entirely extradural lesions with no bone involvement are rare and represent about 12% of all intraspinal hemangiomas. PMID:21572634

  19. A Case of Cerebellar Capillary Hemangioma with Multiple Cysts

    Microsoft Academic Search

    Atsushi Uyama; Atsuhumi Kawamura; Hideyuki Akiyama; Satoshi Nakamizo; Kazuki Yamamoto; Tatsuya Nagashima; Toshiyuki Uetani; Hiroki Takeda; Makiko Yoshida

    2008-01-01

    Intracranial capillary hemangiomas are very rare, though several spinal capillary hemangiomas have recently been reported. We report here a case of intracranial capillary hemangioma with multiple cysts and review the current literature of similar cases. A 4-month-old girl was referred to our hospital for treatment of hydrocephalus and a cerebellar mass lesion. She presented with hemangiomas distributed widely over the

  20. Primary neuroendocrine carcinoma coexisting with hemangioma in the liver: report of a case.

    PubMed

    Akahoshi, Tomohiko; Higashi, Hidefumi; Tsuruta, Satoru; Tahara, Kouichiro; Matsumoto, Toshifumi; Takeuchi, Hideya; Era, Shoichi; Fujita, Fuminori; Muto, Yoichi

    2010-01-01

    Primary hepatic neuroendocrine carcinoma is an extremely rare liver tumor. We herein report a case of primary hepatic neuroendocrine carcinoma coexisting with a hemangioma in a 66-year-old man. Ultrasonography, computed tomography, and magnetic resonance imaging showed a tumor (1.5 cm in diameter) coexisting with a hemangioma in the lateral segment of the liver. Liver biopsy showed malignant cells, and several examinations revealed no alternative primary source. We performed a lateral segmentectomy. Microscopically, the tumor cells had round to oval nuclei and eosinophilic cytoplasm, proliferated in thick trabeculae or solid nests, and formed a focal rosette pattern. Mitotic cells were frequently observed. Immunohistochemically, the tumor cells were positive for the endocrine markers chromogranin A, neuron-specific enolase, and neural cell adhesion molecule, but negative for alpha-fetoprotein and hepatocyte-specific antigen. The patient is still alive after 3 months, without recurrence. PMID:20107963

  1. Red Giant Red Giant White Giant

    E-print Network

    Bechtold, Jill

    Red Giant Red Giant White Giant Red Giant White Giant White Giant Blue Giant Blue Giant Blue Giant. Proxima Centauri, the closest star to the Sun, is a red giant. Mass: 1- 4 Solar Mass StarPower Points: 7

  2. Hepatitis

    MedlinePLUS

    ... with hepatitis show no signs of having the disease, but others may have these symptoms: tiredness without another reason flu-like symptoms — throwing up, feeling hot, etc. yellowing of skin and whites of eyes belly pain (especially on the upper ...

  3. Cervical esophageal hemangioma combined with thyroid cancer.

    PubMed

    Lee, Jong Cheol; Kim, Jeong Won; Lee, Yong Jik; Lee, Seong Rok; Park, Chang-Ryul; Jung, Jong-Pil

    2011-08-01

    Hemangiomas that arise in cervical esophagus are extremely rare, representing 3.3% of all benign esophageal tumors. Although endoscopic mucosal resection (EMR) and potassium titanyl phosphate/yttrium aluminum garnet (KTP/YAG) laser therapy have been used with success for small tumors, the safety and efficacy in the case of large tumors remains uncertain. We report the successful resection of cervical esophageal hemangioma through a cervical esophagotomy in a patient with thyroid cancer who needed a cervical collar incision. PMID:22263178

  4. Pathogenesis of human hemangiosarcomas and hemangiomas.

    PubMed

    Liu, Liping; Kakiuchi-Kiyota, Satoko; Arnold, Lora L; Johansson, Sonny L; Wert, David; Cohen, Samuel M

    2013-10-01

    Hemangiosarcomas are uncommon aggressive vascular tumors that have recently become the focus of attention because several chemicals and pharmaceuticals increase their incidence in mice. The relevance of these mouse vascular tumors to humans is unclear. In the present study, we semiquantitatively evaluated the expression profiles of hematopoietic stem cell markers (CD117 [c-kit], CD133, CD34, and CD45), endothelial cell markers (vascular endothelial growth factor receptor 2, CD31, and factor VIII-related antigen), and a myeloid lineage cell marker (CD14) in human hemangiosarcoma (n = 12) and hemangioma (n = 10) specimens using immunohistochemistry. CD133 was completely negative in almost all cases of hemangiosarcomas and hemangiomas. Most hemangiosarcomas, but not hemangiomas, stained for CD117 and CD45. Both groups diffusely expressed CD34, vascular endothelial growth factor receptor 2, and factor VIII-related antigen; however, hemangiomas had more intense and diffuse CD34 and factor VIII-related antigen expression compared with hemangiosarcomas, whereas CD31 was positive in all hemangiosarcomas but only half of the hemangiomas. CD14 staining was negative in most hemangiosarcoma and hemangioma cases. Our results indicate that multipotential bone marrow-derived hematopoietic stem cells or early endothelial progenitor cells (EPCs) expressing CD117, CD34, and CD45 are involved in hemangiosarcoma formation, whereas hemangiomas originate from late EPCs or differentiated endothelial cells, which have lost the expression of most hematopoietic stem cell markers. This contrasts with our previous results that demonstrated that both hemangiosarcomas and hemangiomas in mice may be derived from early EPCs that are not completely differentiated. PMID:24054722

  5. Radiotherapy in the treatment of vertebral hemangiomas

    SciTech Connect

    Faria, S.L.; Schlupp, W.R.; Chiminazzo, H. Jr.

    1985-02-01

    Symptomatic vertebral hemangiomas are not common. Although radiotherapy has been used as treatment, the data are sparse concerning total dose, fractionation and results. The authors report nine patients with vertebral hemangioma treated with 3000-4000 rad, 200 rad/day, 5 fractions per week, followed from 6 to 62 months. Seventy-seven percent had complete or almost complete disappearance of the symptoms. Radiotherapy schedules are discussed.

  6. Multimodality Imaging of Hemangiomas-Pictorial Essay

    PubMed Central

    N.G., Basawaraj; Anvekar, Sunita Madhukar

    2015-01-01

    Both hemangiomas and vascular malformations are endothelial malformations that closely resemble normal vessels and can be found in all organs of the human body. This pictorial essay encompasses a spectrum of imaging appearances of hemangiomas and vascular malformations. Familiarity of the MR and CT findings can help differentiate these lesions, to confirm the suspected diagnosis, classify the anomaly and document the associated abnormalities. PMID:25954682

  7. Oral Propranolol for Infantile Hemangioma.

    PubMed

    2015-07-16

    To the Editor: The article by Léauté-Labrèze et al. (Feb. 19 issue)(1) emphasizes the therapeutic efficacy and the short-term safety of propranolol in the treatment of infantile hemangiomas. However, recent studies raise concerns about potential long-term neurodevelopmental or cognitive effects of the highly lipophilic propranolol.(2) Indeed, lipophilic beta-blockers cross the blood-brain barrier, leading to sleep and memory disturbances.(3) For example, sleep disturbance, somnolence, and irritability have been observed in many infants treated with propranolol,(4) and this drug has been shown to decrease specific memory functions in adults.(5) A recent review suggested the possibility that blockage of neural pathways critical for . . . PMID:26176392

  8. Oral Propranolol for Infantile Hemangioma.

    PubMed

    Tozzi, Arturo

    2015-07-16

    To the Editor: The article by Léauté-Labrèze et al. (Feb. 19 issue)(1) emphasizes the therapeutic efficacy and the short-term safety of propranolol in the treatment of infantile hemangiomas. However, recent studies raise concerns about potential long-term neurodevelopmental or cognitive effects of the highly lipophilic propranolol.(2) Indeed, lipophilic beta-blockers cross the blood-brain barrier, leading to sleep and memory disturbances.(3) For example, sleep disturbance, somnolence, and irritability have been observed in many infants treated with propranolol,(4) and this drug has been shown to decrease specific memory functions in adults.(5) A recent review suggested the possibility that blockage of neural pathways critical for . . . PMID:26176393

  9. All Those Liver Masses are not Necessarily from the Liver: A Case of a Giant Adrenal Pseudocyst Mimicking a Hepatic Cyst

    PubMed Central

    Patnaik, Soumya; Htut, Alvin; Wang, Peter; Eisenberg, Daniel; Miick, Ronald; Feyssa, Eyob

    2015-01-01

    Patient: Male, 50 Final Diagnosis: Adrenal pseudocys Symptoms: Abdominal pain • fever Medication: — Clinical Procedure: — Specialty: — Objective: Unusual clinical course Background: Most abdominal cysts, including adrenal pseudocysts, are benign and asymptomatic. Rapid enlargement, hemorrhage, infection, rupture with leakage of cyst contents, or pressure on adjacent organs can cause symptoms. Although usually diagnosed incidentally on imaging, determining the origin of a cyst can sometimes be challenging. In these situations, surgical excision and pathological analysis is crucial to diagnosis and management. We report here a case of a giant symptomatic adrenal pseudocyst that closely mimicked a hepatic cyst at presentation. Case Report: A 50-year-old man, with a history of an incidentally detected hepatic cyst, presented with severe abdominal pain, fevers, leukocytosis, and mildly abnormal liver function tests. CT scan revealed a large well defined cystic space-occupying lesion within the liver, with findings suggesting cyst rupture and possible infection. Early laparotomy was performed, and the origin was determined intraoperatively to be right adrenal, which was later confirmed by pathology. Conclusions: Contrast-enhanced CT scan is the criterion standard for evaluation for abdominal cystic masses. Precise diagnosis of a giant abdominal cyst can be challenging. Surgery is both diagnostic and curative in such situations. We also discuss the specific situations in which surgery should be considered in cases of adrenal cystic masses. PMID:26035028

  10. All Those Liver Masses are not Necessarily from the Liver: A Case of a Giant Adrenal Pseudocyst Mimicking a Hepatic Cyst.

    PubMed

    Patnaik, Soumya; Htut, Alvin; Wang, Peter; Eisenberg, Daniel; Miick, Ronald; Feyssa, Eyob

    2015-01-01

    BACKGROUND Most abdominal cysts, including adrenal pseudocysts, are benign and asymptomatic. Rapid enlargement, hemorrhage, infection, rupture with leakage of cyst contents, or pressure on adjacent organs can cause symptoms. Although usually diagnosed incidentally on imaging, determining the origin of a cyst can sometimes be challenging. In these situations, surgical excision and pathological analysis is crucial to diagnosis and management. We report here a case of a giant symptomatic adrenal pseudocyst that closely mimicked a hepatic cyst at presentation. CASE REPORT A 50-year-old man, with a history of an incidentally detected hepatic cyst, presented with severe abdominal pain, fevers, leukocytosis, and mildly abnormal liver function tests. CT scan revealed a large well defined cystic space-occupying lesion within the liver, with findings suggesting cyst rupture and possible infection. Early laparotomy was performed, and the origin was determined intraoperatively to be right adrenal, which was later confirmed by pathology. CONCLUSIONS Contrast-enhanced CT scan is the criterion standard for evaluation for abdominal cystic masses. Precise diagnosis of a giant abdominal cyst can be challenging. Surgery is both diagnostic and curative in such situations. We also discuss the specific situations in which surgery should be considered in cases of adrenal cystic masses. PMID:26035028

  11. Children with Rare Chronic Skin Diseases: Hemangiomas and Epidermolysis Bullosa.

    ERIC Educational Resources Information Center

    Jones, Sheila Dove; Miller, Cynthia Dieterich

    The paper reports on studies involving children having the rare chronic skin diseases of hemangiomas and epidermolysis bullosa (characterized by easy blistering). One study compared the self-concept and psychosocial development of young (mean age 46 months) children (N=19) with hemangiomas with 19 children without hemangiomas. Findings indicated…

  12. Infantile hemangioma is originated from placental trophoblast, fact or fiction?

    PubMed

    Sun, Zhi-Yong; Yi, Cheng-Gang; Zhao, Huan; Yin, Guo-Qian; Gao, Ming; Liu, Yan-Bin; Qin, Jia-De; Wang, Shou-Feng; Guo, Shu-Zhong

    2008-09-01

    Infantile hemangiomas are common, benign tumors, distinctive for their perinatal presentation, rapid growth and subsequent involution. Hemangiomas can pose serious concerns to the cosmetic and psychosocial development of the afflicted child, but none of the current therapeutic modalities is ideal to date, partly because the origin of the pathogenic ECs in infantile hemangioma is unknown. Many clues and evidences suggest a link between infantile hemangiomas and the maternal placental trophoblasts. Shared expression of distinct endothelial markers in hemangioma and placental tissues raises a possibility that infantile hemangioma is originated from placental trophoblast. Moreover, the findings of a very high similarity between the transcriptomes of placenta and hemangioma provide strong support for this theory. Furthermore, epidemiologic and clinical evidences accumulated in recent years also suggest the placental trophoblast as the cell of origin for infantile hemangioma. These findings imply a unique relationship between hemangioma and the placental trophoblast and suggest a hypothesis that infantile hemangioma is originated from placental trophoblast. The hypothesis could provide new understanding of these vascular tumors of childhood and may become the most promising research fields for the etiology of infantile hemangiomas. Further study of the precise mechanisms for the placental trophoblast originated hemangiomas will produce new preventive strategies and therapeutic avenues, possibly immunologic treatment, to the very difficult problem. PMID:18440158

  13. Hemangioma

    MedlinePLUS

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  14. Hemangiomas

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  15. Beta-blockers for hemangiomas.

    PubMed

    Gelmetti, C; Cavalli, R

    2014-12-01

    Infantile hemangiomas (IHs) are the most common tumors in infancy. Their typical natural history is characterized by an early rapid growth in the first months of life and by a slow spontaneous involution in the first years of life. Even though spontaneous regression of IHs could suggest therapeutic abstention, systemic treatment is the therapy of choice in many patients in which these situations occur: 1) rapid growth of IHs; 2) location of IHs in aesthetically critic areas; 3) recurrent hemorrhages, ulcerations or infections of IHs; 3) IHs interfering with important physiological functions (breathing, feeding, vision, hearing, etc.); 4) large or multicentric IHs that can cause heart failure. Since 2008, systemic administration of propranolol, an old non?selective ??blocker, was found, serendipitously, to improve the treatment of IHs replacing older and more dangerous therapies like oral steroids, vincristine, interferon?alpha or vascular lasers. At present, oral propranolol has dramatically changed the approach of IHs because its efficacy is almost 100% and its action is rapid, without important side effects. The formal approval by FDA and EMA has been obtained in Spring 2014. PMID:25366892

  16. Differentiation Between Hemangiomas and Metastases of the Liver with Ultrafast MR Imaging: PreliminaryResultswithT2 Calculations

    Microsoft Academic Search

    Mark A. Goldberg; Sanjay Saini; Peter F. Hahn; Thomas K. Egglin; Peter A. Mueller

    We studied the efficacy of T2 measurements at high field strength in distinguishing between liver hemangiomas and hepatic metastases when an ultrafast (single-excita- tion) MR imaging technique is used. Fourteen patients with known liver tumors were imaged in a 2.O-T prototype ultrafast MR scanner with a spin-echo (infinite TR and TE of 30-340 msec) pulse sequence. Each image was obtained

  17. ?6-integrin is required for the adhesion and vasculogenic potential of hemangioma stem cells

    PubMed Central

    Smadja, David M.; Guerin, Coralie L.; Boscolo, Elisa; Bieche, Ivan; Mulliken, John B.; Bischoff, Joyce

    2013-01-01

    Background Infantile hemangioma (IH) is the most common tumor of infancy. Hemangioma stem cells (HemSC) are a mesenchymal subpopulation isolated from IH CD133+ cells. HemSC can differentiate into endothelial and pericyte/smooth muscle cells and form vascular networks when injected in immune-deficient mice. ?6-Integrin subunit has been implicated in the tumorgenicity of glioblastoma stem cells and the homing properties of hematopoietic, endothelial and mesenchymal progenitor cells. Therefore, we investigated the possible function(s) of ?6-integrin in HemSC. Methods/Results We documented ?6-integrin expression in IH tumor specimens and HemSC by RT-qPCR and flow cytometry. We examined the effect of blocking or silencing ?6-integrin on the adhesive and proliferative properties of HemSCin vitro and the vasculogenic and homing properties of HemSCin vivo. Targeting ?6-integrin in cultured HemSC inhibited adhesion to laminin but had no effect on proliferation. Vessel-forming ability in Matrigel implants and hepatic homing after intravenous delivery were significantly decreased in ?6-integrin siRNA transfected HemSC. Conclusion ?6-Integrin is required for HemSC adherence to laminin, vessel formation in vivo and for homing to the liver. Thus, we uncovered an important role for ?6 integrin in the vasculogenic properties of HemSC. Our results suggest that ?6-integrin expression on HemSC could be a new target for anti-hemangioma therapy. PMID:24022922

  18. A Rapidly Enlarging Cutaneous Hemangioma in Pregnancy

    PubMed Central

    Ma’ayeh, Marwan; Purandare, Nikhil; Harrison, Michelle; Geary, Michael P.

    2014-01-01

    This is a case of a rapidly enlarging cutaneous pedunculated tumor on a patient’s thumb during her pregnancy. This was excised and identified as a hemangioma. A literature search identified a possible hormonal factor in causing an accelerated growth of this tumor. PMID:25332760

  19. Endoscopic transoral and transmaxillary excision of the infratemporal fossa hemangioma.

    PubMed

    Nakaya, Muneo; Kida, Wataru; Ito, Akiko; Yoshihara, Shintaro; Fuchigami, Teruhiko

    2015-06-01

    Hemangiomas in the infratemporal fossa (ITF) are extremely rare benign vascular tumors. For many tumors of the ITF, with the exception of some small hemangiomas, a lateral facial approach has often been required. Recently, however, there have been some reports that minimally invasive endoscopic surgery can be used in the ITF; this would reduce the risk of surgical complications. To date, there has been no report of a hemangioma of the ITF exceeding 6cm being resected by the endoscopic approach without facial incisions. Here, however, we report two cases of ITF hemangiomas that were completely extracted endoscopically, using a transmaxillary and transoral approach, without facial incisions or surgical complications. PMID:25555907

  20. Extraosseous, Epidural Cavernous Hemangioma with Back Pain

    PubMed Central

    Ozkal, Birol; Yaldiz, Can; Yaman, Onur; Ozdem?r, Nail; Dalbayrak, Sedat

    2015-01-01

    Summary Background Cavernous malformations are characterized by enlarged vascular structures located in benign neural tissues within the cerebellum and spinal cord of the central nervous system. Cavernous hemangiomas (CHs) account for 5% to 12% of all spinal vascular malformations. Case Report We removed a hemorrhagic thoracic mass in a 40-year-old male patient who presented with progressive neurological deficits. Conclusions We found it appropriate to present this case due to its rarity. PMID:25960818

  1. Preoperative arterial embolization of large liver hemangiomas

    PubMed Central

    Topalo?lu, Serdar; O?uz, ?ükrü; Kalayc?, Orhan; Öztürk, M. Halil; Çal?k, Adnan; Dinç, Hasan; Çobano?lu, Ümit

    2015-01-01

    PURPOSE We aimed to investigate the efficacy and safety of preoperative selective intra-arterial embolization (PSIAE) in the surgical treatment of large liver hemangiomas. METHODS Data of 22 patients who underwent resection of large liver hemangiomas were retrospectively analyzed. PSIAE was performed in cases having a high risk of severe blood loss during surgery (n=11), while it was not applied in cases with a low risk of blood loss (n=11). RESULTS A total of 19 enucleations and six anatomic resections were performed. Operative time, intraoperative bleeding amount, Pringle period, and blood transfusion were comparable between the two groups (P > 0.05, for all). The perioperative serum aspartate transaminase level was not different between groups (P = 1.000). Perioperative total bilirubin levels were significantly increased in the PSIAE group (P = 0.041). Postoperative hospital stay was longer in the PSIAE group. Surgical complications were comparable between groups (P = 0.476). CONCLUSION Patients who underwent PSIAE due to a high risk of severe blood loss during resection of large liver hemangiomas had comparable operative success as patients with a low risk of blood loss who were operated without PSIAE. Hence, PSIAE can be used for the control of intraoperative blood loss, especially in surgically difficult cases. PMID:25858526

  2. Giant Pyogenic Granuloma in a Patient with Chronic Lymphocytic Leukemia

    PubMed Central

    Plovanich, Molly; Tsibris, Hillary C.; Lian, Christine G.; Mostaghimi, Arash

    2014-01-01

    Pyogenic granuloma, also known as lobular capillary hemangioma, is a common benign vascular proliferative lesion that can present at any age on the skin or mucous membranes. Most lesions do not exceed 2 cm, but there are a handful of giant cutaneous pyogenic granulomas that have been reported, often in individuals with underlying immune dysfunction. Here, we report the first giant pyogenic granuloma in a patient with a hematological malignancy, chronic lymphocytic leukemia. PMID:25408651

  3. Incidence and Clinical Characteristics of Periocular Infantile Hemangiomas

    PubMed Central

    Alniemi, Saba T.; Griepentrog, Gregory J.; Diehl, Nancy; Mohney, Brian G.

    2013-01-01

    Objective To report the incidence, demographics, and clinical findings among a population-based cohort of children with periocular infantile hemangiomas. Design Retrospective population-based cohort. Participants All patients (< 19 years of age) diagnosed with periocular infantile hemangiomas while residing in Olmsted County, Minnesota, from January 1, 1965, through December 31, 2004. Methods The medical records of all potential patients identified by the Rochester Epidemiology Project were reviewed. Main Outcome Measures Incidence, demographics, and clinical findings of periocular infantile hemangiomas. Results A total of 43 children were diagnosed with periocular infantile hemangiomas during the 40-year period, yielding an incidence of 5.4 per 100,000 <19 years (95% CI: 3.8–7.1), or a birth prevalence of 1 in 1586 live births. Thirty (70%) were female (p<0.001). There was a history of maternal infertility in approximately 1 in 5 children and premature birth in 1 in 8 children. Twenty-six (60.5%) had other abnormalities, including secondary hemangiomas in 9 (20.9%). The majority of patients (n = 41, 95%) had unilateral disease and most hemangiomas (n = 37, 86%) were located on the upper eyelid. Conclusions In this population-based study, periocular infantile hemangiomas occurred in 1 in 1586 live births and were most prevalent on the unilateral upper eyelid of Caucasian females. Prevalent associations included maternal infertility and premature birth. Other abnormalities, including secondary hemangiomas in 1 in 5 children, were common in this cohort. PMID:22776927

  4. MR imaging of breast hemangioma in female infants

    Microsoft Academic Search

    Y. Miaux; F. Lemarchand-Venencie; F. Cyna-Gorse; J. Frija; Y. Cohen; L. Dubertret; M. Laval-Jeantet

    1992-01-01

    Breast hemangioma in female infants is a rare benign lesion, prone to spontaneous regression. But when the lesion regresses there is a risk of breast atrophy if the breast bud is included in or very close to the hemangioma. A trial of corticosteroid therapy could be proposed to prevent this risk, but one must be sure that the breast bud

  5. Adult Pancreatic Hemangioma: Case Report and Literature Review

    PubMed Central

    Mundinger, Gerhard S.; Gust, Shannon; Micchelli, Shien T.; Fishman, Elliot K.; Hruban, Ralph H.; Wolfgang, Christopher L.

    2009-01-01

    We report an adult pancreatic hemangioma diagnosed on pathological specimen review following pylorus preserving pancreaticoduodenectomy for a symptomatic cystic mass in the head of the pancreas. Eight cases of adult pancreatic hemangioma have been reported in literature since 1939. Presenting symptoms, radiographic diagnosis, pathologic characteristics, and treatment of adult pancreatic hemagiomas are discussed following review of all published cases. PMID:19421421

  6. Pediatric Pancreatic Hemangioma: A Case Report and Literature Review

    Microsoft Academic Search

    Richard J England; Helen Woodley; Catherine Cullinane; Patricia McClean; Jenny Walker; Mark D Stringer

    2006-01-01

    Context The pancreas is an unusual site for a hemangioma in an infant. A child with obstructive jaundice caused by a pancreatic hemangioma is presented and management strategies for this benign tumor are discussed. Case report A 5-month-old girl presented with a 2-week history of jaundice, pale stools and dark urine. Liver function tests confirmed obstructive jaundice. An abdominal ultrasound

  7. Low-Dose Proton Beam Therapy for Circumscribed Choroidal Hemangiomas

    Microsoft Academic Search

    Eric Frau; Frank Rumen; George Noel; Sabine Delacroix; Jean-Louis Habrand

    2004-01-01

    Objective: To evaluate the efficacy and safety of pro- ton beam therapy for complicated circumscribed cho- roidal hemangiomas. Methods: The study was a retrospective nonrandom- ized investigation. Seventeen consecutive patients, re- ferred to the Institut Gustave-Roussy, Villejuif, France, for circumscribed choroidal hemangioma associated with serous retinal detachment were studied. Each eye re- ceived a total dose of 20 cobalt gray

  8. [Subglottic hemangioma as the cause of laryngostenosis in young children].

    PubMed

    Soldatski?, Iu L; Onufrieva, E K

    1997-01-01

    In 1985 to 1996 we observed and treated 22 children (19 girls and 3 boys) with subglottic hemangioma. The children had pronounced clinical symptoms of rough and scraping breathing. Skin hemangiomas were found in 73% of patients. The diagnosis was made using microlaryngoscopy. Laser destruction (11 children) and cryosurgery (9 children) provided cure in the majority of relevant patients. PMID:9461799

  9. [Infantile hemangiomas: the revolution of beta-blockers].

    PubMed

    Leaute-Labreze, Christine

    2014-12-01

    Infantile hemangioma is the consequence of both postnatal vasculogenesis and angiogenesis. Hypoxia appears to play an important role as a contributory factor. Infantile hemangiomas have variable clinical features: superficial, deep or mixed. They can be localized or segmental involving a large skin area. Localized infantile hemangiomas are usually benign, unless they are located near a noble structure (airway orbit...), while segmental infantile hemangioma may be associated with complex underlying birth defects (PHACES and SACRAL syndromes). Clinical follow-up of infants with infantile hemangioma must be particularly careful in the first weeks of life since 80% of all infantile hemangiomas have reached their final size at age 5 months. A majority of infantile hemangiomas are mild and do not required any treatment. Main indications for treatment are: vital risk (heart failure, respiratory distress), functional risk (amblyopia, swallowing disorders...), painful ulceration and disfigurement (face involvement of nose, lips...). Propranolol, has been quickly adopted as the first line medical treatment for complicated infantile hemangioma; and it is the only treatment to have a marketing authorization in this indication. It is recommended to begin the treatment as early as possible before three months of age to minimize the risk of complications and sequelae. PMID:25665327

  10. [Symptomatic vertebral hemangioma related to pregnancy. A case report].

    PubMed

    Jankowski, Roman; Nowak, Stanis?aw; Kasprzyk, Mariusz; Szpurek, Dariusz; Zukiel, Ryszard; Sokó?, Bartosz; Szmeja, Jacek; Szubert, Sebastian

    2012-01-01

    Hemangioma is the most common primary tumor of the spine. Pregnancy is a risk factor increasing the possibility of disclosure or exacerbation of symptoms of spinal hemangioma. This paper presents a case of 32-year-old woman with hemangioma of Th6 vertebrae, which was revealed by paresis of the lower limbs and sphincters dysfunction at 34 weeks gestation. Pregnancy has ended with a cesarean section. Then posterolateral thoracotomy and removal of hemangioma were performed. Spinal cord was decompressed and stabilization of the spine with metal implants was carried out. Histological examination discovered cavernous hemangioma weaving. The patient is followed up in the outpatient clinic. Despite the improvement of neurological status--enhancement of the sensory function and development of bladder and rectal sphincter automatism--she did not regain the ability to walk alone. PMID:22384642

  11. Use of propranolol for treatment of hemangiomas in PHACE syndrome.

    PubMed

    Solomon, T; Ninnis, J; Deming, D; Merritt, T A; Hopper, A

    2011-11-01

    We report the case of a 29-week preterm infant with PHACE (posterior fossa malformations, hemangionas, arterial anomalies, cardiac anomalies, eye anomalies) syndrome. PHACE syndrome is a neurocutaneous disorder with large facial segmental hemangionas associated with anomalies of the brain, eye, heart and aorta. The hemangiomas in our patient were problematic, distorting the airway and interfering with respirations to the point of requiring mechanical ventilation. Consultation with several different centers with medical expertize in treatment of congenital hemangiomas revealed different views on the best management strategy. In this infant, the hemangiomas progressed with failure to involute despite currently recommended therapy including corticosteroids and vincristine. Therefore, the infant was treated with propranolol and had significant regression of the hemangiomas. The use of propranolol for the treatment of infantile hemangiomas is reviewed. PMID:22037156

  12. Synovial hemangioma: a rare benign synovial lesion.

    PubMed

    Khanna, Geetika; Gupta, Anu; Gupta, Vikas

    2008-01-01

    We report an unusual case of a 10-year-old female with complaints of pain and swelling of the right knee for the last 4 years along with the limitation of movement for last 1 year. Repeated fine needle aspirations yielded blood and a provisional diagnosis of hemarthrosis was suggested. Coagulation profile subsequently carried out was found to be within normal limits. Arthroscopic biopsy was performed and tissue was sent for histopathological examination. A diagnosis of synovial hemangioma was made. Subtotal synovectomy was performed and the lesion was completely excised. The patient is completely asymptomatic and shows no signs of recurrence at 1 year. PMID:18603700

  13. Masson's intravascular hemangioma masquerading as effort thrombosis.

    PubMed

    Kumar, Amit; Surowiec, Scott; Nigwekar, Priya; Illig, Karl A

    2004-10-01

    An otherwise healthy 55-year-old white woman had acute onset of right arm swelling. No precipitating factors were identified. Venograms revealed an occluded subclavian vein, and catheter-directed thrombolysis was performed. After lysis a persistent residual intraluminal filling defect was identified, with persistent symptoms. Partial claviculectomy was performed, the mass was removed, and patch venoplasty carried out, with good outcome. Pathologic analysis demonstrated the mass to be a Masson's hemangioma, a papillary proliferation of thin-walled capillaries intimately associated with thrombus. Considered a benign intravascular lesion, the treatment of choice is complete excision. PMID:15472612

  14. Pathology Case Study: Hemangioma and Severe Thrombocytopenia

    NSDL National Science Digital Library

    Bontempo, Franklin

    This is a transfusion pathology case study presented by the University of Pittsburgh Department of Pathology in which a 3-week-old female has hemangioma and severe thrombocytopenia. Visitors are given laboratory values and images, and are granted the opportunity to diagnose the patient. This is an excellent resource for students in the health sciences to familiarize themselves with using laboratory results to diagnose. It is also a helpful site for educators to use to introduce or test student learning in transfusion pathology medicine.

  15. Hemangioma of the Interatrial Septum: CT and MRI Features

    SciTech Connect

    Hrabak-Paar, Maja, E-mail: majahrabak@gmail.com [University Hospital Center Zagreb, University of Zagreb School of Medicine, Department of Diagnostic and Interventional Radiology (Croatia); Huebner, Marisa [University Hospital Mainz (Germany); Stern-Padovan, Ranka; Lusic, Mario [University Hospital Center Zagreb, University of Zagreb School of Medicine, Department of Diagnostic and Interventional Radiology (Croatia)

    2011-02-15

    Hemangioma of the heart is a rare primary benign tumor mainly appearing as enhancing, homogenous, well-circumscribed mass. We report a case of a 61-year-old asymptomatic woman, whose echocardiography showed a cardiac mass, which was described as the atypical myxoma of the right atrium. For further imaging, contrast-enhanced computed tomography and cardiac magnetic resonance imaging were undertaken, which showed a tumor located in the interatrial septum with imaging characteristics of hemangioma. In the literature, cardiac hemangioma is usually described as an intensely enhancing mass. In our opinion, early peripheral puddling of contrast material with filling in on delayed images is a typical pattern of its enhancement. This characteristic, in addition to high signal intensity on T2-weighted images, allows differentiation of a hemangioma from other benign and malignant tumors.

  16. Intracranial hemangiomas in a patient with POEMS syndrome

    Microsoft Academic Search

    G. D. Maurer; J. Schittenhelm; U. Ernemann; V. A. J. Kempf; R. Ritz; M. Weller; F. Schmidt

    2010-01-01

    POEMS syndrome is a rare multi-system disease with typical features of polyneuropathy, organomegaly, endocrinopathy, monoclonal\\u000a plasmaproliferative disorder and skin changes. We describe a 44-year-old woman with polyneuropathy, hepatomegaly, IgA lambda-plasmacytoma,\\u000a thrombocytosis, papilledema with elevated protein levels in cerebrospinal fluid and multiple cutaneous hemangiomas who was\\u000a diagnosed with three intracranial lesions. Histology revealed capillary hemangiomas, one of them displaying partially glomeruloid

  17. Management of Infantile Hemangiomas: Current Trends

    PubMed Central

    Sethuraman, Gomathy; Yenamandra, Vamsi K; Gupta, Vishal

    2014-01-01

    Infantile hemangiomas (IH) are common vascular tumours. IH have a characteristic natural course. They proliferate rapidly during the early infantile period followed by a period of gradual regression over several years. Most of the uncomplicated IH undergo spontaneous involution, with a small proportion of cases requiring intervention. These are children with IH in life-threatening locations, local complications like haemorrhage, ulceration and necrosis and functional or cosmetic disfigurements. Systemic corticosteroids have been the first line of treatment for many years. Recently, non-selective beta-blockers, such as oral propranalol and topical timolol, have emerged as promising and safer therapies. Other treatment options include interferon ? and vincristine which are reserved for life-threatening haemangiomas that are unresponsive to conventional therapy. This review mainly focuses on the current trends and evidence-based approach in the management of IH. PMID:25136206

  18. Percutaneous Pediculoplasty for Vertebral Hemangioma Involving the Neural Arch: A Case Report

    SciTech Connect

    Fuwa, Sokun, E-mail: sofuwa@luke.or.jp; Numaguchi, Yuji; Kobayashi, Nobuo; Saida, Yukihisa [St. Luke's International Hospital, Department of Diagnostic and Interventional Radiology (Japan)

    2008-01-15

    Vertebral hemangiomas occasionally involve the neural arch and they can be symptomatic. We report a case of symptomatic vertebral hemangioma mainly involving the unilateral neural arch which was successfully treated with percutaneous pediculoplasty using a single-needle technique.

  19. Oral Versus High-Dose Pulse Corticosteroids for Problematic Infantile Hemangiomas: A Randomized, Controlled Trial

    Microsoft Academic Search

    Elena Pope; Bernice R. Krafchik; Colin Macarthur; Diana Stempak; Derek Stephens; Miriam Weinstein; Nhung Ho; Sylvain Baruchel

    2010-01-01

    OBJECTIVES.Oral systemic corticosteroids are the mainstay of treatment for problem- atic hemangiomas; however, current information is based on anecdotal experience and retrospective studies. We aimed to determine whether systemic steroids are efficacious in proliferating hemangioma and to compare the efficacy and safety of 2 corticosteroid treatment modalities. PATIENTS AND METHODS.Twenty patients with problematic hemangiomas of infancy were randomly assigned to

  20. Proton Beam Irradiation Using a Light-Field Technique for the Treatment of Choroidal Hemangiomas

    Microsoft Academic Search

    R. V. Paul Chan; Yoshihiro Yonekawa; Dimitra Skondra; John E. Munzenrider; J. Michael Collier; Evangelos S. Gragoudas; Ivana K. Kim

    2010-01-01

    Background\\/Aims: To describe the clinical outcomes of patients with circumscribed and diffuse choroidal hemangiomas treated by proton beam irradiation using a nonsurgical light-field technique. Methods: A retrospective chart review was performed on a series of 19 patients (19 eyes) with choroidal hemangiomas treated with proton beam therapy between July 1988 and August 2005. Choroidal hemangiomas were treated with proton beam

  1. A rare cause of recurrent gastrointestinal bleeding: mesenteric hemangioma

    PubMed Central

    Kazimi, Mircelal; Ulas, Murat; Ibis, Cem; Unver, Mutlu; Ozsan, Nazan; Yilmaz, Funda; Ersoz, Galip; Zeytunlu, Murat; Kilic, Murat; Coker, Ahmet

    2009-01-01

    Lower gastrointestinal hemorrhage accounts for approximately 20% of gastrointestinal hemorrhage. The most common causes of lower gastrointestinal hemorrhage in adults are diverticular disease, inflammatory bowel disease, benign anorectal diseases, intestinal neoplasias, coagulopathies and arterio-venous malformations. Hemangiomas of gastrointestinal tract are rare. Mesenteric hemangiomas are also extremely rare. We present a 25-year-old female who was admitted to the emergency room with recurrent lower gastrointestinal bleeding. An intraluminal bleeding mass inside the small intestinal segment was detected during explorative laparotomy as the cause of the recurrent lower gastrointestinal bleeding. After partial resection of small bowel segment, the histopathologic examination revealed a cavernous hemagioma of mesenteric origin. Although rare, gastrointestinal hemangioma should be thought in differential diagnosis as a cause of recurrent lower gastrointestinal bleeding. PMID:19178725

  2. A rare cause of recurrent gastrointestinal bleeding: mesenteric hemangioma.

    PubMed

    Kazimi, Mircelal; Ulas, Murat; Ibis, Cem; Unver, Mutlu; Ozsan, Nazan; Yilmaz, Funda; Ersoz, Galip; Zeytunlu, Murat; Kilic, Murat; Coker, Ahmet

    2009-01-01

    Lower gastrointestinal hemorrhage accounts for approximately 20% of gastrointestinal hemorrhage. The most common causes of lower gastrointestinal hemorrhage in adults are diverticular disease, inflammatory bowel disease, benign anorectal diseases, intestinal neoplasias, coagulopathies and arterio-venous malformations. Hemangiomas of gastrointestinal tract are rare. Mesenteric hemangiomas are also extremely rare.We present a 25-year-old female who was admitted to the emergency room with recurrent lower gastrointestinal bleeding. An intraluminal bleeding mass inside the small intestinal segment was detected during explorative laparotomy as the cause of the recurrent lower gastrointestinal bleeding. After partial resection of small bowel segment, the histopathologic examination revealed a cavernous hemagioma of mesenteric origin.Although rare, gastrointestinal hemangioma should be thought in differential diagnosis as a cause of recurrent lower gastrointestinal bleeding. PMID:19178725

  3. Disfiguring facial hemangioma compromising labial functionality: a case report.

    PubMed

    Rinaldi, Simona; Rossi, Antonio; Conversi, Andrea; Toscani, Marco; Tarallo, Mauro; Fino, Pasquale; Scuderi, Nicolò

    2013-01-01

    Hemangiomas are proliferative lesions characterized by increased endothelial cell turnover. Lip hemangiomas can distort lip anatomy and are at increased risk of ulceration and/or bleeding, which lead to impaired function and disfigurement. Surgery can provide active treatment but it can be problematic because vermilion tissue is unique and not found elsewhere on the body. Since there is no similar tissue that can easily be used for reconstructing missing vermilion, its preservation is essential for a satisfactory cosmetic result. We present the case of a 74 year old woman suffering from a large hemangioma of the mid-face and particulary with an angiomatous ulcerated lesion at the level of the lower lip. We describe clinical management and surgical treatment of this pathology. PMID:23648694

  4. Primary surgical excision for pediatric orbital capillary hemangioma.

    PubMed

    Krema, Hatem

    2015-05-01

    We report the technique and outcome of surgical excision of subcutaneous orbital capillary hemangioma causing eye globe displacement in two children. Primary surgical excision was performed with blunt dissection along the tumor walls using a cotton-tipped applicator as the dissecting tool with simultaneous outward gentle traction on the tumor wall. Despite the deep and extensive orbital involvement, complete excision of the hemangiomas was achievable with this technique, which permitted excellent visualization of the surgical planes throughout the procedures. Deep and extensive pediatric orbital capillary hemangioma can be surgically excised with the suggested technique, which obviates the need for intralesional or systemic medical therapy, yielding optimal cosmetic and functional outcomes, shortly after surgery. PMID:24117453

  5. Symplastic hemangioma: report of two cases.

    PubMed

    Goh, Seng Geok Nicholas; Dayrit, Johannes F; Calonje, Eduardo

    2006-11-01

    Symplastic hemangioma is characterized by degenerative atypia of vascular smooth muscle and interstitial cells within a pre-existing vascular lesion with minimal endothelial cell atypia. We describe an additional two cases of this distinctive but poorly recognized entity. On histology, both lesions revealed a cirsoid aneurysm-type appearance with thick-walled and variably dilated blood vessels. The vascular endothelial cells showed mild nuclear hyperchromasia with no multilayering or mitoses. The atypical cells, either located within the vascular smooth muscle wall or within the interstitium, were spindle or epithelioid with varying degrees of hyperchromasia, nuclear enlargement, pleomorphism, and multinucleation. Perivascular hemorrhage, vascular thrombosis, and focal papillary endothelial hyperplasia were uniformly present. The variably fibrous to edematous stroma showed hemosiderin deposits and a mononuclear inflammatory infiltrate. Clusters of adipocytes were present within the superficial dermis. Rare atypical mitoses and occasional bizarre lipoblast-like stromal cells were identified in one tumor. Immunohistochemistry showed focal smooth muscle actin positivity in the pleomorphic cells of the vascular walls. CD68 and CD34 stained occasional stromal cells in the interstitial location. Both the cases showed no recurrence. The bizarre cytologic changes are interpreted as degenerative in nature and probably akin to that observed in ancient schwannoma and uterine symplastic leiomyoma. PMID:17083693

  6. Thymic Cavernous Hemangioma With a Left Innominate Vein Aneurysm.

    PubMed

    Nakada, Takeo; Akiba, Tadashi; Inagaki, Takuya; Morikawa, Toshiaki; Ohki, Takao

    2015-07-01

    Here we report a case of thymic cavernous haemangioma with the left innominate vein aneurysm. A 43-year-old man presented with chest pain. Enhanced chest computed tomography revealed an anterior mediastinal tumor measuring 60 × 52 × 38 mm with multiple venous lakes and focal specks of calcification, composed of a low-density soft tissue mass along with a left innominate vein aneurysm. We preoperatively diagnosed the mass as a thymic hemangioma and subsequently performed surgical resection. Pathologic diagnosis was a thymic cavernous hemangioma with a left innominate vein aneurysm, which is very rare. PMID:26140781

  7. [Epithelioid hemangioma of bone: a rare pathologic entity].

    PubMed

    Bouziani, Ammar; Bettaieb, Ilhem; Bougrine, Fethi; Laabidi, Besma; Ferchichi, Leila; Dhouha, Belghith; Ben Romdhane, Khaled; Khlil, Abdelaziz

    2003-10-01

    Epithelioid hemangioma of bone is a rare benign vascular lesion. Since its first description by Rosai in 1979 about thirty cases have been reported. We report two new cases diagnosed in patients aged 21 and 7 years. Both patients had multiple lesions on the legs. Bone pain was the main symptom. Routine laboratories studies were unremarkable. Bon radiographs showed an expansive process of the bone. Histological and immunochemical features were typical of epithelioid hemangioma of the bone. Treatment consisted in above knee amputation for the first patient and therapeutic abstention for the second. Both patients are alive without progressive local disease or metastasis. PMID:14752390

  8. Spontaneous Hemothorax Caused by Pulmonary Micro-Venous Hemangioma.

    PubMed

    Homma, Takahiro; Yamamoto, Yutaka; Imura, Johji; Doki, Yoshinori; Yoshimura, Naoki; Senda, Kazutaka; Toge, Masayoshi; Ojima, Toshihiro; Shimada, Yoshifumi; Masawa, Nobuhide

    2015-07-01

    Various etiologies of spontaneous hemothorax have been reported, though the cause remains unidentified in some patients despite an exploratory thoracotomy. We report on an 89-year-old man with spontaneous hemothorax resolved by partial resection of the lung using complete video-assisted thoracoscopic surgery. The histopathologic findings revealed a ruptured micro-venous hemangioma located just below the bleeding visceral pleura. To the best of our knowledge, this is the first report of spontaneous hemothorax caused by a pulmonary micro-venous hemangioma. PMID:26140771

  9. Synovial hemangioma and osteoarthritis of the knee: a case report.

    PubMed

    De Gori, Marco; Galasso, Olimpio; Gasparini, Giorgio

    2014-01-01

    This report presents an adult patient suffering from knee osteoarthritis and gross hypertrophy of the synovium, preoperatively interpreted as a nonspecific synovial reaction. The patient underwent a total knee replacement and a complete synovectomy was performed. Histological examination disclosed a synovial hemangioma, which is a rare intra-articular, benign tumor of youth. PMID:25429592

  10. Open surgical excision of subglottic hemangioma in children

    Microsoft Academic Search

    Brian J. Wiatrak; James S. Reilly; Allan B. Seid; Seth M. Pransky; Jasper V. Castillo

    1996-01-01

    Subglottic hemangioma is an unusual entity which may involute spontaneously without aggressive surgical intervention; although tracheotomy is sometimes necessary. The actual time course for involution is not clear by reviewing the literature [1,14]. Numerous treatment modalities are described for the treatment of this condition, including tracheotomy, CO2 laser ablation and intralesional steroid injection with or without endotracheal intubation. Surgical resection

  11. Contrasting strategic approaches to the management of subglottic hemangiomas

    Microsoft Academic Search

    Patrick Froehlich; Allan B. Seid; Alain Morgon

    1996-01-01

    The standards of treatment of subglottic hemangiomas are steroids and laser vaporization. If these methods do not provide a sufficient airway, a tracheotomy may be required. Analysis of the data available in the literature shows that there is a place for other therapeutic solutions. Open surgical excision could be one of them but is controversial. So far, it represented a

  12. [Infantile hemangioma and propranolol: a therapeutic "revolution". Literature review].

    PubMed

    Yilmaz, L; Dangoisse, C; Semaille, P

    2013-01-01

    Infantile hemangioma (IH) is the most common benign vascular tumour affecting children. Most infantile hemangiomas are self-limiting, but some require specific treatment. Propranolol has been proposed for the treatment of infantile hemangiomas. The aim of this study is to explore the mechanism of action of propranolol for the treatment of infantile hemangiomas and to demonstrate its safety and efficacy through a review of the literature. The non cardioselective bêta-blocker propranolol has been used in a pediatric setting for 40 years and, since 2008, has a new indication. A clearly significant improvement has been observed in the condition of children with complicated IH (10%) treated with propranolol. This new indication has been widely described in the international literature. Various explanations have been put forward for the mechanism of action including a vasoconstrictor, antiangiogenic and apoptotic effect of propranolol on the different cells making up an IH. Overall tolerance is good and the efficacy markedly superior to that of any other treatments used for this purpose. In conclusion, with its good tolerance profile and superior efficacy versus all the other available therapies, propranolol can be considered to be a first-line treatment for complicated IH. PMID:24505868

  13. [The place of MRI in the hepatic tumors].

    PubMed

    Mnif, Najla; Ellouze, Thouraya; Boubela, Tarek; Oueslati, Seddik; Hamza, Radhi

    2005-02-01

    MRI semeiology of hepatic tumors was assessed with a retrospective study of 132 patients explored between May 1998 and December 2001. MR examinations were acquired with a one Tesla operating system. All images were acquired by a T2-weighted fast spin echo MR and dynamic flash MR with Gadolinium. Hemangiomas demonstrate characteristic signs in most cases, as was described in the literature. However, adenoma, hepatocellular carcinoma and metastases have various and less specific features. PMID:15969233

  14. Indocyanine green angiographic findings in diffuse choroidal hemangioma associated with Sturge-Weber syndrome

    Microsoft Academic Search

    F. Wen; Dezheng Wu

    2000-01-01

    Purpose: To analyze indocyanine green angiography (ICGA) features in one case of diffuse choroidal hemangioma associated with Sturge-Weber\\u000a syndrome. Methods: Color fundus photography, fluorescein angiography (FA) and ICGA were performed in a patient with diffuse choroidal hemangioma\\u000a associated with Sturge-Weber syndrome. Results: The diffuse choroidal hemangioma was not identified by FA. ICGA revealed that the vascular tissue of the diffuse

  15. Massive Hemoptysis due to Endotracheal Hemangioma: A Case Report and Literature Review

    PubMed Central

    Yu, Yeonsil; Lee, Suhyeon; An, Jinyoung; Lee, Jeongmin; Kim, Jihoon; Lee, Youngkyung; Jung, Eunah; Song, Sookhee; Kim, Hyeok

    2015-01-01

    Tracheal hemangioma is a rare benign vascular tumor in adults. We reported a case of massive hemoptysis caused by a cavernous hemangioma in a 75-year-old man. This is the first report, to our knowledge, of a tracheal cavernous hemangioma that presented with massive hemoptysis. The lesion was removed with a CO2 laser under rigid laryngoscopy. Endovascular tumors, such as tracheobronchial hemangiomas, should be considered a diagnostic option in cases of massive hemoptysis without a significant underlying lung lesion. PMID:25861344

  16. Long-term follow up of renal anastomosing hemangioma mimicking renal angiosarcoma.

    PubMed

    Heidegger, Isabel; Pichler, Renate; Schäfer, Georg; Zelger, Bernhard; Zelger, Bettina; Aigner, Friedrich; Bektic, Jasmin; Horninger, Wolfgang

    2014-08-01

    Anastomosing hemangioma of the kidney is a very rare neoplasm, currently 19 cases have been reported in the literature. First described in 2009, histopathologically anastomosing hemangioma is similar to aggressive angiosarcoma. No long-term follow-up data of anastomosing hemangioma have been described yet. Here, we present the case of a healthy 56-year-old man diagnosed in 2002 with a 7?×?5-cm anastomosing hemangioma mimicking an aggressive renal angiosarcoma. The patient underwent nephrectomy and has been followed up disease free for 13?years. PMID:24650180

  17. Rapamycin suppresses self-renewal and vasculogenic potential of stem cells isolated from infantile hemangioma.

    PubMed

    Greenberger, Shoshana; Yuan, Siming; Walsh, Logan A; Boscolo, Elisa; Kang, Kyu-Tae; Matthews, Benjamin; Mulliken, John B; Bischoff, Joyce

    2011-12-01

    Infantile hemangioma (IH) is a common childhood vascular tumor. Although benign, some hemangiomas cause deformation and destruction of features or endanger life. The current treatments, corticosteroid or propranolol, are administered for several months and can have adverse effects on the infant. We designed a high-throughput screen to identify the Food and Drug Administration-approved drugs that could be used to treat this tumor. Rapamycin, an mTOR (mammalian target of Rapamycin) inhibitor, was identified, based on its ability to inhibit proliferation of a hemangioma-derived stem cell population, human vasculogenic cells, which we had previously discovered. In vitro and in vivo studies show that Rapamycin reduces the self-renewal capacity of the hemangioma stem cells, diminishes differentiation potential, and inhibits the vasculogenic activity of these cells in vivo. Longitudinal in vivo imaging of blood flow through vessels formed with hemangioma stem cells shows that Rapamycin also leads to regression of hemangioma blood vessels, consistent with its known anti-angiogenic activity. Finally, we demonstrate that Rapamycin-induced loss of stemness can work in concert with corticosteroid, the current standard therapy for problematic hemangioma, to block hemangioma formation in vivo. Our studies reveal that Rapamycin targets the self-renewal and vascular differentiation potential in patient-derived hemangioma stem cells, and suggests a novel therapeutic strategy to prevent formation of this disfiguring and endangering childhood tumor. PMID:21938011

  18. Iris Depigmentation: An Unusual Complication of Intralesional Corticosteroid Injection for Capillary Hemangioma

    PubMed Central

    Al-Mahdi, Huda

    2010-01-01

    Intralesional injection of corticosteroids has been used successfully in the treatment of adenexal hemangiomas, with advantages of easy administration, rapid action, repeatability, efficacy and safety. We report a case of an eight-month-old female infant who underwent intralesional corticosteroid injection for capillary hemangioma that had resulted in amblyopia of her left eye from ptosis. Two weeks after the injection, the hemangioma showed some regression but at that point iris depigmentation of the affected eye was noted. The iris depigmentation remained unchanged during her follow-up visit with significant regression of the hemangioma, associated ptosis and astigmatism. PMID:20543946

  19. Hepatitis B

    MedlinePLUS

    ... of the hepatitis B virus. This is called chronic hepatitis B. People with chronic hepatitis may not have symptoms ... to look for liver damage if you have chronic hepatitis B: Albumin level Liver function tests Prothrombin time You ...

  20. Percutaneous Technique for Sclerotherapy of Vertebral Hemangioma Compressing Spinal Cord

    SciTech Connect

    Gabal, Abdelwahab M. [Al-Azhar University Medical Center, Sayed GalalHospital, Port Saeed Str. 540, Cairo 11563 (Egypt)

    2002-12-15

    Purpose: In this study we report a percutaneous technique to achieve sclerosis of vertebral hemangioma and decompression of the spinal cord and nerve roots. Methods: Under CT guidance the affected vertebral body is punctured by a biopsy needle and sclerosant is injected directly into the tumor. In the case of large paravertebral extension, additional injection is given in the paravertebral soft tissue component to induce shrinkage of the whole tumor mass and release of the compressed spinal cord. Results: Using this technique we treated five patients in whom vertebral hemangioma gave rise to neurologic symptoms.In three patients, sclerotherapy was the only treatment given. In the other two patients, sclerotherapy was preceded by transcatheter embolization. Neither decompressive surgery, radiation therapy nor stabilization was required with this technique. Conclusion: Our experience with CT-guided intraosseous sclerotherapy has proved highly satisfactory.

  1. Red blood cell scan in cavernous hemangioma of the larynx

    SciTech Connect

    Finkelstein, D.M.; Noyek, A.M.; Kirsh, J.C. (Univ. of Toronto, Ontario (Canada))

    1989-09-01

    Cavernous hemangioma of the larynx is an uncommon, difficult-to-diagnose vascular tumor for which there is no significant imaging literature to date. The possibility of improved diagnosis through RBC scanning might obviate injudicious biopsy and potential hemorrhage within the airway. Utilizing the radionuclide RBC scan, which labels the patient's own RBCs initially with cold pyrophosphate, and subsequently with technetium 99m as pertechnetate, we have identified successfully four patients with cavernous hemangioma of the larynx. All presented with a supraglottic mass involving at least the aryepiglottic fold and arytenoid region unilaterally. This report describes our satisfactory diagnostic imaging experience with the radionuclide RBC scan and suggests both its imaging specificity and its role in the management of this lesion.

  2. Photodynamic therapy of choroidal hemangioma: two case reports

    Microsoft Academic Search

    Irene Barbazetto; Ursula Schmidt-Erfurth

    2000-01-01

    Background: Photocoagulation, cryotherapy and radiotherapy have been used to treat angiomatous lesions. Depending on the location of\\u000a the angioma, these treatments can cause additional, significant functional damage. Photodynamic therapy (PDT) however, allows\\u000a a selective occlusion of vascular lesions without damaging adjacent retinal structures.?\\u000a Methods: Two patients with isolated choroidal hemangiomas involving the posterior pole were treated with PDT. Treatments were

  3. Segmental ulcerated perineal hemangioma of infancy: a complex case of PELVIS syndrome successfully treated using a multidisciplinary approach.

    PubMed

    Kaushik, Shivani B; Kwatra, Shawn G; McLean, Thomas W; Powers, Alexander; Atala, Anthony J; Yosipovitch, Gil

    2013-01-01

    We report a case of PELVIS (perineal hemangioma, external genital malformations, lipomyelomeningocele, vesicorenal abnormalities, imperforate anus and skin tag) syndrome in which hemangioma in the perineal area was misdiagnosed at birth as diaper rash. Investigations revealed associated vesicorenal and spinal abnormalities. We emphasize careful diagnosis of suspicious lesions at birth and confirm the successful use of propranolol in treating ulcerated segmental hemangiomas. PMID:23278237

  4. Primary angiosarcoma of the parotid gland arising from benign congenital hemangioma

    Microsoft Academic Search

    Stefania Damiani; Barbara Corti; Fabrizio Neri; Guido Collina; Franco Bertoni

    2003-01-01

    A case of malignant transformation of a benign congenital hemangioma of the parotid gland is presented. The malignant tumor occurred in a woman with a history of congenital hemangioma surgically removed 8 years previously. No radiotherapy had been administered at the time of primary excision. The recurrent tumor consisted of a large lesion occupying nearly all the parotid gland and

  5. CT in hepatic cirrhosis and chronic hepatitis.

    PubMed

    Valls, Carlos; Andía, Eduard; Roca, Yolanda; Cos, Mònica; Figueras, Juan

    2002-02-01

    Cirrhosis is a diffuse liver disease with premalignant potential in which hepatocellular carcinoma (HCC) frequently develops. The hemodynamics of contrast material are the key to diagnosis of focal liver lesions with computed tomography (CT). Lesions with arterial-dominant vascularity, such as HCC, show brisk enhancement during the arterial phase, whereas lesions with portal blood supply can appear as hyperenhancing lesions in the portal phase. The advent of helical CT has significantly improved the CT examination of the liver because the arterial phase can be displayed independently of the portal phase. The addition of arterial phase imaging to conventional portal phase imaging seems to improve tumor detection and characterization. Although HCC is the single most frequent tumor seen in chronic liver disease, other lesions such as peripheral cholangiocarcinoma and hemangioma should be considered in the differential diagnosis. Optimization of helical CT techniques may allow better detection and characterization of these lesions. In addition to tumor detection, CT plays an important role in preoperative staging of HCC as well as in preoperative assessment of patient candidates to hepatic transplantation. The use of CT angiography with maximum intensity projection techniques may allow for better preoperative work-up and vascular mapping in HCC patients. This article shows the spectrum of helical CT findings in chronic liver disease and specifically in the imaging of HCC and other focal lesions. PMID:11866222

  6. Detection and characterization of focal hepatic lesions with diffusion-weighted MR imaging: a pictorial review.

    PubMed

    Kanematsu, Masayuki; Goshima, Satoshi; Watanabe, Haruo; Kondo, Hiroshi; Kawada, Hiroshi; Noda, Yoshifumi; Aomatsu, Akinori; Moriyama, Noriyuki

    2013-04-01

    The purpose of this pictorial review is to discuss the usefulness and limitations of diffusion-weighted (DW) MR imaging of the liver, demonstrating DW images of a variety of focal hepatic diseases. We include hepatocellular carcinoma, borderline-lesions in cirrhosis, metastasis, cavernous hemangioma, cyst, focal nodular hyperplasia, hepatic adenoma, abscess, and hematoma. DW imaging is an important supplementary sequence of routine MR imaging protocols of the liver. Radiologists need to understand its usefulness and limitations in the detection and characterization of benign and malignant focal hepatic diseases. PMID:22842549

  7. MR imaging during arterial-portography (MR-AP) in the detection of hepatic tumor: comparison with CT-AP.

    PubMed

    Kajiya, Y; Nakajo, M; Miyazono, N; Kajiya, Y; Fujiyoshi, F; Ichinari, N

    1997-01-01

    This study was undertaken to compare the detection rate of hepatic space occupying lesion (SOL)s between computed tomography during arterial portography (CT-AP) and magnetic resonance imaging during arterial portography (MR-AP) and the differences in time intensity curve on MR-AP between HCC, metastatic tumor, FNH, and hemangioma. We performed CT-AP and MR-AP in 17 patients including 14 cases of HCC and one each of metastasis, FNH, and hemangioma. MR-AP was performed by Turbo-FLASH sequence. There was no statistically significant difference between CT-AP and MR-AP in detecting satellite lesions in terms of smallest diameter and number of flow defects (p > 0.05). Hemangioma showed rapid enhancement after the first pass and, consequently, the same enhancement as the hepatic parenchyma. MR-AP was comparable to CT-AP in the detection of hepatic SOLs. Hemangioma showed an enhancement pattern different from those of HCC, metastatic tumor, and FNH, which showed patterns similar to each other. PMID:9495785

  8. Characterization of focal hepatic masses by dynamic contrast-enhanced MR imaging: findings in 311 lesions.

    PubMed

    Quillin, S P; Atilla, S; Brown, J J; Borrello, J A; Yu, C Y; Pilgram, T K

    1997-01-01

    This study aimed to determine the overall accuracy of known enhancement patterns for the characterization of a large series of focal hepatic masses on dynamic contrast-enhanced magnetic resonance (MR) images. Breath-hold T1-weighted images of the liver acquired before intravenous gadolinium administration and serially over 6-10 min after contrast injection were acquired in < 25 a using FLASH or rapid spin-echo pulse sequences. A total of 311 proven focal hepatic masses in 128 patients were analyzed, including 192 malignant lesions (166 metastases and 26 hepatomas) and 119 benign lesions (48 cavernous hemangiomas, 45 hepatic cysts, and 26 other abnormalities). The lesions were evaluated for a variety of characteristics independently by two reviewers who were blinded to results. Cavernous hemangiomas showed early peripheral nodular enhancement (80% sensitivity and 99% specificity) and hepatic cysts showed no enhancement (100% sensitivity and 95% specificity). Hepatic metastases showed variable, moderate enhancement (47% by one reviewer and 74% by the other). Metastatic lesions from hypervascular primary neoplasms displayed peak enhancement during the hepatic artery dominant (bolus) phase, while other malignant neoplasms showed later peak enhancement (72% sensitivity and 77% specificity). Five metastatic foci with early homogeneous enhancement showed a delayed peripheral washout of contrast (rim sign), while no nonmetastatic foci displayed this finding (3% sensitivity and 100% specificity). Characteristic enhancement patterns of focal hepatic lesions were described in a large series of patients. This study confirms results of previous investigators who have shown that early nodular peripheral enhancement was highly specific for hemangiomas and lack of enhancement was highly specific for hepatic cysts. Hypervascular metastatic foci show earlier peak enhancement than other malignant lesions. Some (2-3%) metastatic lesions display a peripheral washout of contrast on serial images, with 100% specificity. PMID:9201674

  9. Aggressive vertebral hemangioma as a rare cause of myelopathy.

    PubMed

    Sari, Hidayet; Uludag, Murat; Akarirmak, Ulku; Ornek, Nurettin Irem; Gun, Kerem; Gulsen, Fatih

    2014-01-01

    Vertebral hemangiomas (VHs) are common lesions in the adult population. They are usually asymptomatic and found incidentally on radiological imaging. New-onset back pain followed by subacute progression of thoracal myelopathy is the most common presentation in patients with neurological deficit. Differential diagnoses would include metastasis, multiple myeloma, lymphoma, Paget disease, osseous tumors such as Ewing sarcoma or hemangioblastoma and blood dyscrasia. We present a 41 year-old-male patient with thoracal VH causing myelopathy that completely improved after rehabilitation program with embolization and vertebroplasty procedures. PMID:23948851

  10. Cavernous Hemangioma of the Skull and Meningioma: Association or Coincidence?

    PubMed Central

    Kilani, M.; Darmoul, M.; Hammedi, F.; Ben Nsir, A.; Hattab, M. N.

    2015-01-01

    Intraosseous cavernous hemangiomas of the skull are rare. Meningiomas are quite frequently encountered in a neurosurgical practice. The association between these two entities is nevertheless very uncommon. The authors present a case of a 72-year-old woman suffering from headache. The MRI showed a parietal meningioma with adjacent thick bone. The meningioma and the bone were removed. The histological examination confirmed the diagnosis of meningioma and revealed a cavernoma of the skull. The relationship between the lesions suggests more than a coincidental association. Several hypotheses are proposed to explain common causal connections. PMID:25960899

  11. Epithelioid Hemangioma of Lingual Alveolar Mucosa: An Immunohistochemical Case Report

    PubMed Central

    Nangia, Rajat; Puri, Abhiney; Gupta, Rakhi; Bansal, Sucheta; Chauhan, Isha

    2014-01-01

    Epithelioid hemangioma is a rare benign vascular lesion that presents as a nodular lesion in the skin of head and neck region. It is a superficial vascular entity which can either be due to tumor or reactive lesion, but the exact etiology is still unknown. We hereby present a rare case which has been reported with the history of small nodular-like growth on mandibular buccal and lingual area. The excisional biopsy was performed and tissue was submitted for histopathological diagnosis. The immunohistochemistry was performed to check the expression of CD31 marker which proved that origin of epithelioid cells was vascular. PMID:24715910

  12. Cavernous hemangioma of the skull and meningioma: association or coincidence?

    PubMed

    Kilani, M; Darmoul, M; Hammedi, F; Ben Nsir, A; Hattab, M N

    2015-01-01

    Intraosseous cavernous hemangiomas of the skull are rare. Meningiomas are quite frequently encountered in a neurosurgical practice. The association between these two entities is nevertheless very uncommon. The authors present a case of a 72-year-old woman suffering from headache. The MRI showed a parietal meningioma with adjacent thick bone. The meningioma and the bone were removed. The histological examination confirmed the diagnosis of meningioma and revealed a cavernoma of the skull. The relationship between the lesions suggests more than a coincidental association. Several hypotheses are proposed to explain common causal connections. PMID:25960899

  13. Uncommon hepatic tumors: iconographic essay - Part 1*

    PubMed Central

    Pedrassa, Bruno Cheregati; da Rocha, Eduardo Lima; Kierszenbaum, Marcelo Longo; Bormann, Renata Lilian; Torres, Lucas Rios; D'Ippolito, Giuseppe

    2014-01-01

    Most malignant liver tumors are represented by hepatocellular carcinoma and cholangiocarcinoma; however a variety of other uncommon hepatic lesions might also be found. Common lesions such as hemangioma, focal nodular hyperplasia and metastases are well known and have already been extensively documented in the literature. The diagnosis of typical hepatic lesions may be done with some reliability by means of several imaging methods; on the other hand, uncommon lesions normally represent a diagnostic challenge for the radiologist. In this first part of the study, the authors will approach five uncommon liver tumors - angiosarcoma, angiomyolipoma, cystadenoma/biliary carcinoma, epithelioid hemangioendothelioma, and fibrolamellar hepatocellular carcinoma -, describing their main characteristics and image findings with focus on computed tomography and magnetic resonance imaging. PMID:25741106

  14. Large capillary hemangioma of the temporal bone with a dural tail sign: A case report.

    PubMed

    Yang, Guang; Li, Chenguang; Chen, Xin; Liu, Yaohua; Han, Dayong; Gao, Xin; Kawamoto, Keiji; Zhao, Shiguang

    2014-07-01

    The present study reports a rare case of large capillary hemangioma of the temporal bone with a dural tail sign. A 57-year-old female presented with pulsatile tinnitus and episodic vertigo associated with a ten-year history of an intermittent faint headache. Magnetic resonance imaging revealed a mass in the right petrous bone, which was hypointense on T1-weighted images and heterogeneously hyperintense on T2-weighted images, and showed a dural tail sign following gadolinium administration. Pre-operatively, this tumor was believed to be a meningioma. During surgery, the vascular tumor was removed by a modified pterional approach. A histopathological examination indicated that the tumor was a capillary hemangioma. Although intraosseous capillary hemangiomas are rare, they most frequently affect the temporal bone. Hemangiomas of the temporal bone may mimic other more common basal tumors. The diagnosis is most often made during surgical resection. The dural tail sign is not specific for meningioma, as it also occurs in other intracranial or extracranial tumors. The treatment of intratemporal hemangiomas is complete surgical excision, with radiotherapy used for unresectable lesions. To the best of our knowledge, the present study is the fourth case of intraosseous intracranial capillary hemangioma, but the largest intratemporal hemangioma to be reported in the literature to date. PMID:24959241

  15. Hepatitis D

    MedlinePLUS

    ... Skip Content Marketing Share this: Main Content Area Hepatitis D Hepatitis D is a viral infection that damages the liver, but it can propagate only when the hepatitis B virus is also present. Approximately 15 million ...

  16. Viral Hepatitis

    MedlinePLUS

    ... hepatitis B immune globulin (H-BIG) and the hepatitis B vaccine within 12 hours after birth. If you have ... liver disease All children at age 1 The hepatitis B vaccine is usually given in three doses over six ...

  17. Liver lesions with hepatic capsular retraction.

    PubMed

    Blachar, Arye; Federle, Michael P; Sosna, Jacob

    2009-10-01

    Retraction of the liver capsule may be associated with a diverse spectrum of benign and malignant etiologies. The more common causes include focal confluent fibrosis in cirrhotic livers, cholangiocarcinoma, and treated liver tumors, such as hepatocellular carcinoma, metastases, and lymphoma. Less common etiologies include primary sclerosing cholangitis, epithelioid hemangioendothelioma, hepatic hemangioma, solitary fibrous tumor of the liver, and hepatic inflammatory pseudotumor. Hepatic capsular retraction may also result from iatrogenic and noniatrogenic trauma. Due to the diversity and different nature of the various etiologies associated with this sign, it is important that radiologists be familiar with the characteristic features of these abnormalities, to avoid misdiagnosis that may adversely affect the therapeutic approach. It is also important to know that, contrary to some reports, hepatic capsular retraction is not a sign of malignant disease. The purpose of this article is to familiarize readers with the spectrum of benign and malignant etiologies of this sign and to point out additional computed tomographic findings that may allow confident diagnosis of the specific hepatic lesion responsible for the capsular retraction. The hepatic capsular and subcapsular regions may be affected by focal or diffuse pathologies affecting the liver. This hepatic area is more prone to be involved in various malignant and benign diseases due to several factors: the negative subdiaphragmatic pressure that may draw infected material and malignant cells toward the diaphragm, the perihepatic ligaments connecting the liver capsule with adjacent viscera, forming a direct root of dissemination, and the systemic blood inflow that supplies this region in addition to the portal and hepatic arterial blood flow. This is the reason for the multiple pathologic conditions and pseudolesions that occur at the hepatic capsular and subcapsular regions. PMID:19842567

  18. Multiple hemangiomas of the urinary bladder in a child with gross hematuria

    PubMed Central

    Kim, Yeun Yoon; Kim, Myung-Joon; Lee, Mi-Jung; Kim, Ji-Ye

    2015-01-01

    We report a case of multiple hemangiomas involving the urinary bladder in a 4-year-old boy who presented with recurrent episodes of gross hematuria. On ultrasonography, compared with the bladder wall, the lesions presented as multiple isoechoic polypoid intraluminal masses with mildly increased vascularity on color Doppler exam. Cavernous hemangioma was confirmed by cold-cup biopsy, and the all lesions were coagulated with a Holmium laser. Despite their rarity, bladder hemangiomas should be included in the differential diagnosis of multiple intravesical masses in children with gross hematuria. PMID:25672772

  19. Multiple hemangiomas of the urinary bladder in a child with gross hematuria.

    PubMed

    Kim, Yeun Yoon; Kim, Myung-Joon; Lee, Mi-Jung; Kim, Ji-Ye

    2015-07-01

    We report a case of multiple hemangiomas involving the urinary bladder in a 4-year-old boy who presented with recurrent episodes of gross hematuria. On ultrasonography, compared with the bladder wall, the lesions presented as multiple isoechoic polypoid intraluminal masses with mildly increased vascularity on color Doppler exam. Cavernous hemangioma was confirmed by cold-cup biopsy, and the all lesions were coagulated with a Holmium laser. Despite their rarity, bladder hemangiomas should be included in the differential diagnosis of multiple intravesical masses in children with gross hematuria. PMID:25672772

  20. Hemangioma of the Maxillary Sinus Presenting as a Mass: CT and MR Features

    PubMed Central

    Jung, Won Sang; Yoo, Chang Young; Park, Yong-Jin; Ihn, Yon Kwon

    2015-01-01

    Hemangiomas of the sinonasal tract are rare, and because these lesions lack the typical signs or symptoms, they can be confused with other malignant conditions. We report a case of cavernous hemangioma of the maxillary sinus in a 68-year-old man that was completely resected by endoscopic sinus surgery. Although computed tomography (CT) and magnetic resonance imaging (MRI) showed several enhancing areas within the tumor, the substantial bone erosion and remodeling made it difficult to differentiate this cavernous hemangioma from other expansile maxillary sinus lesions. We present the CT and MR findings of this lesion and discuss the differential diagnoses and potential therapeutic approaches. PMID:25901262

  1. Diode laser photocoagulation in PHACES syndrome hemangiomas: a case series

    NASA Astrophysics Data System (ADS)

    Romeo, U.; Russo, N.; Polimeni, A.; Favia, G.; Lacaita, M. G.; Limongelli, L.; Franco, S.

    2014-01-01

    PHACES syndrome is a pediatric syndrome with cutaneous and extra-cutaneous manifestations, such as Posterior fossa defects, Hemangiomas, Arterial lesions, Cardiac abnormalities/aortic coarctation, Eye abnormalities and Sternal cleft. Facial hemangiomas affect the 75% of patients and may arise on the oral mucosa or perioral cutaneous regions. In this study we treated 26 Intraoral Haemangiomas (IH) and 15 Perioral Haemangiomas (PH) with diode laser photocoagulation using a laser of 800+/-10nm of wavelength. For IH treatment an optical fiber of 320 ?m was used, and the laser power was set ted at 4 W (t-on 200 ms / t-off 400ms; fluence: 995 J/cm2). For PH treatment an optical fiber of 400 ?m at the power of 5 W was used (t-on 100 ms / t-off 300 ms; fluence: 398 J/cm2). IH healed after one session (31%), the other (69%) after two sessions of Laser therapy. In each session, only a limited area of the PH was treated, obtaining a progressive improvement of the lesion. Diode laser photocoagulation is an effective option of treatment for IH and PH in patients affected by PHACE because of its minimal invasiveness. Moreover laser photocoagulation doesn't have side effects and can be performed repeatedly without cumulative toxicity. Nevertheless, more studies are required to evaluate the effectiveness of the therapy in mid and long time period.

  2. Hepatitis C and HIV

    MedlinePLUS

    ... Potential Related Health Problems Opportunistic Infections Hepatitis A Hepatitis B Hepatitis C Tuberculosis Oral Health Issues Cancer Cardiovascular ... of viral hepatitis are hepatitis A virus (HAV), hepatitis B virus (HBV), and hepatitis C virus (HCV). HBV ...

  3. Hepatitis B and HIV

    MedlinePLUS

    ... Health Problems : Hepatitis B Translate Text Size Print Hepatitis B What is Hepatitis? Hepatitis means inflammation of the liver. This condition ... our related pages, Hepatitis A and Hepatitis C . Hepatitis B and HIV About 10% of people living ...

  4. Giant megaureter

    Microsoft Academic Search

    D. Basak; S. K. Sinha Roy; Asoka Ghosh

    1992-01-01

    Two girls aged 9 and 18 months and one boy aged 18 months presented with a huge intra-abdominal mass, recurrent infections, and failure to thrive. Following investigations surgery was performed, establishing the diagnosis of giant megaureter, and nephroureterectomy was carried out. Two patients are alive and well; one died of septicaemia. Problems of management of giant megaureter are discussed with

  5. Male breast hemangioma--a rare entity: a case report and review of the literature.

    PubMed

    Vourtsi, Athina; Zervoudis, Stephane; Pafiti, Agathi; Athanasiadis, Socratis

    2006-01-01

    We report the case of a 77-year-old man with a very rare breast tumor: hemangioma. The clinical examination found a large (6 cm diameter) lump and mammography revealed a well-defined high-density lesion with lobulated contour. Simple mastectomy was performed. The histology confirmed the diagnosis of benign hemangioma. There has been no local recurrence after 9 years of follow-up. There is very little literature on this type of tumor in men. Generally hemangiomas are large and ultrasound and magnetic resonance imaging (MRI) are useful for the diagnosis. The important differential diagnosis with angiosarcoma is based on specific histologic patterns. Moreover, malignant transformation of hemangioma is rare, but possible. PMID:16684325

  6. A hemangioma of the sigmoid colon mesentery presenting as a retroperitonealtumor: a case report and review

    PubMed Central

    2014-01-01

    Hemangiomas of the gastrointestinal tract and mesentery are uncommon benign vascular lesions. While spontaneous bleeding is the hallmark of the gastrointestinal tumor variant, clinical signs of mesenteric hemangiomas are mostly unspecific. Despite the increasing imaging quality of computerized tomography (CT), in most cases the final diagnosis is established through surgery and histopathologic analysis of a macrobiopsy. We present a case report of a 20-year-old female patient who was admitted with progressive abdominal distension and suffered from persistent abdominal pain for 3 months. A large retroperitoneal tumor mass was detected on the CT scan. Due to radiographic signs of an intraabdominal liposarcoma, an explorative laparotomy was performed revealing a large hemangioma originating from the mesosigmoid. Although rare, gastrointestinal hemangiomas should be kept in mind by oncological visceral surgeons as one differential diagnosis of large intraabdominal tumorous masses, especially in young adults. PMID:24684941

  7. A case of atypical caudate lobe hemangioma mimicking hepatocellular carcinoma: CT and angiographic manifestations

    Microsoft Academic Search

    Hsin-Chi Chen; Chi-Ming Lee; Ching-Shyang Chen; Chih-Hsiung Wu

    We report a case of caudate lobe hemangioma with an atypical CT enhancement pattern. In the present case, hemangioma exhibited a very subtle discontinuous peripheral rim enhancement at the post-enhanced arterial phase, and the peripheral enhanced zone had a moderately increased enhancement degree and with widened enhancement thickness during the portal-phase and delayed-phase. The slow enhancement rate for this caudate

  8. Sclerosing cavernous hemangioma of the cavernous sinus mimicking congenital fibrosis of the extraocular muscles.

    PubMed

    Gesite-de Leon, Bhambi; Demer, Joseph L

    2014-06-01

    A girl with a clinical presentation suggestive of unilateral congenital fibrosis of the extraocular muscles type 3 at 2 years of age years later developed progressive ophthalmoplegia and an afferent pupillary defect. Reimaging revealed a lesion diagnosed as a sclerosing cavernous sinus hemangioma with focal calcification. Cavernous sinus hemangioma is a rare, benign vascular malformation whose growth causes cranial nerve compression. Although frequently missed on routine neuroimaging, characteristic radiologic findings distinguish it from lesions such as meningioma. PMID:24751811

  9. Endovascular Treatment of Huge Cervicofacial Hemangioma Complicated by Kasabach-Merritt Syndrome

    Microsoft Academic Search

    Masaki Komiyama; Hideki Nakajima; Shouhei Kitano; Hiroaki Sakamoto; Hiroko Kurimasa; Hajime Ozaki

    2000-01-01

    A 2-month-old girl with a huge cervicofacial hemangioma complicated by Kasabach-Merritt syndrome was presented. Two weeks corticosteroid treatment was ineffective, and deterioration of coagulation parameters and compromise of the airway and left vision due to huge hemangioma prompted use of endovascular treatment. Transfemoral arterial embolization using polyvinyl alcohol particles resulted in rapid clinical improvement. Endovascular treatment should be considered as

  10. Intralesional corticosteroid therapy in proliferating head and neck hemangiomas: A review of 155 cases

    Microsoft Academic Search

    M. T. Chen; E. K. Yeong; S. Y Horng

    2000-01-01

    Purpose: The purpose of this paper is to review the effect of intralesional corticosteroid therapy in the treatment of 155 head and neck hemangiomas.Methods: In the past 10 years, we have treated 155 proliferating head and neck hemangiomas with intralesional corticosteroid injections. Three to 6 injections of triamcinolone acetonide (10 mg\\/mL) in monthly intervals were given. Using slides and chart

  11. Bilateral diffuse choroidal hemangiomas with unilateral facial nevus flammeus in Sturge–Weber Syndrome

    Microsoft Academic Search

    Arezo Amirikia; Ingrid U Scott; Timothy G Murray

    2000-01-01

    PURPOSE: To report bilateral choroidal hemangiomas associated with unilateral facial nevus flammeus in Sturge–Weber syndrome.METHODS: Case report.RESULTS: A 6-year-old male with a left facial nevus flammeus and a history of a left cerebral angioma had been followed 2 years for increasing esotropia. Examination demonstrated bilateral diffuse choroidal hemangiomas with overlying exudative retinal detachments. After bilateral external beam radiotherapy, the retinal

  12. Resection of a laryngeal hemangioma in an adult using an ultrasonic scalpel: A case report

    PubMed Central

    WANG, XURUI; ZHAO, XIAODONG; ZHU, WEI

    2015-01-01

    Adult laryngeal hemangioma is an extremely rare and slowly progressing vascular tumor. The present study describes the first reported case of a male with a large laryngeal hemangioma that was treated by ultrasonic scalpel. A 61-year-old male presented to our hospital with a recurrent pharyngeal foreign body sensation, without hoarseness, hemoptysis, expectoration or dyspnea. A blue-black mass was detected in the right pyriform sinus, with a morular surface and a wide pedicle positioned lateral to the right arytenoid cartilage and aryepiglottic fold under electronic laryngoscopy. Following tracheotomy under local anesthesia, right superior laryngeal artery ligation and laryngeal hemangioma resection via a lateral neck hypopharyngeal approach were performed under general anesthesia using an ultrasonic scalpel. Pathological examination verified that the tumor was a cavernous hemangioma. On day 11, subsequent to post-operative anti-inflammatory and symptomatic treatment, electronic laryngoscopy showed that the arytenoid mucosal edema had decreased and that the movement of the arytenoid was good. There was no recurrence of hemangioma during a 2-year follow-up period. Therefore, it is recommended that complete surgical resection using an ultrasonic scalpel should be considered for similar cases involving large laryngeal hemangiomas. PMID:26137093

  13. COSMC Is Overexpressed in Proliferating Infantile Hemangioma and Enhances Endothelial Cell Growth via VEGFR2

    PubMed Central

    Lee, Jian-Jr; Huang, Miao-Juei; Huang, John; Hung, Ji-Shiang; Chen, Ming-Ting; Huang, Min-Chuan

    2013-01-01

    Infantile hemangiomas are localized lesions comprised primarily of aberrant endothelial cells. COSMC plays a crucial role in blood vessel formation and is characterized as a molecular chaperone of T-synthase which catalyzes the synthesis of T antigen (Gal?1,3GalNAc). T antigen expression is associated with tumor malignancy in many cancers. However, roles of COSMC in infantile hemangioma are still unclear. In this study, immunohistochemistry showed that COSMC was upregulated in proliferating hemangiomas compared with involuted hemangiomas. Higher levels of T antigen expression were also observed in the proliferating hemangioma. Overexpression of COSMC significantly enhanced cell growth and phosphorylation of AKT and ERK in human umbilical vein endothelial cells (HUVECs). Conversely, knockdown of COSMC with siRNA inhibited endothelial cell growth. Mechanistic investigation showed that O-glycans were present on VEGFR2 and these structures were modulated by COSMC. Furthermore, VEGFR2 degradation was delayed by COSMC overexpression and facilitated by COSMC knockdown. We also showed that COSMC was able to regulate VEGF-triggered phosphorylation of VEGFR2. Our results suggest that COSMC is a novel regulator for VEGFR2 signaling in endothelial cells and dysregulation of COSMC expression may contribute to the pathogenesis of hemangioma. PMID:23424651

  14. Hepatic tumors: magnetization transfer MR imaging with gadolinium enhancement.

    PubMed

    Onaya, H; Yoshioka, H; Itai, Y; Niitsu, M; Anno, I; Okumura, T

    1995-01-01

    Thirty patients with 15 hepatocellular carcinomas, 10 metastases, four hemangiomas, and one cholangiocarcinoma underwent magnetic resonance imaging at 1.5 T with T1-weighted, T2-weighted spin-echo (SE) images, gradient-echo (GRE) magnetization transfer (MT) images, and gadolinium-enhanced T1-weighted SE and MT-GRE images. The MT effect and lesion-liver contrast-to-noise ratio (C/N) were calculated and visual assessment (qualitative analysis) performed for unenhanced and enhanced MT-GRE images and enhanced T1-weighted SE images. The C/N values for hepatic adenocarcinomas (seven metastases and one cholangiocarcinoma) and hemangiomas were larger for enhanced MT-GRE images (adenocarcinoma, 8.4 +/- 2.3 [P < .01]; hemangioma 24 +/- 2.1 [P < .05]) than for enhanced GRE images (5.0 +/- 1.9 and 18 +/- 2.7, respectively). These enhancing tumors had the highest scores in the qualitative analysis. Enhanced MT-GRE images showed no advantage for depiction of hepatocellular carcinomas relative to the other images. PMID:7633103

  15. Imaging of nontraumatic hemorrhagic hepatic lesions.

    PubMed

    Casillas, V J; Amendola, M A; Gascue, A; Pinnar, N; Levi, J U; Perez, J M

    2000-01-01

    Spontaneous hepatic bleeding is a rare condition. In the absence of trauma or anticoagulant therapy, hepatic hemorrhage may be due to underlying liver disease. The most common causes of nontraumatic hepatic hemorrhage are hepatocellular carcinoma and hepatic adenoma. Such hemorrhage can also occur in patients with other liver tumors, such as focal nodular hyperplasia, hemangiomas, and metastases. Other conditions associated with this entity include HELLP syndrome, amyloidosis, and miscellaneous causes. Imaging plays a significant role in the diagnosis and management of this potentially lethal entity. In the appropriate clinical setting, the diagnosis of a hemorrhagic liver lesion is suggested when a hyperechoic mass or a mass with hyperechoic areas is seen at ultrasonography, a hyperattenuating mass is seen at computed tomography (CT), or a mass with high-signal-intensity areas is seen at T1-weighted magnetic resonance (MR) imaging. The signal intensity of blood can be increased or decreased on MR images depending on when the hemorrhage is imaged. The presence and extent of commonly associated subcapsular hematomas and hemoperitoneum can be easily ascertained with CT. During the first 24-72 hours, acute hematomas are hyperattenuating on nonenhanced CT scans; later, they decrease in attenuation and sometimes develop a pseudocapsule. PMID:10715337

  16. Hepatitis B Vaccine

    MedlinePLUS

    ... as a combination product containing Hepatitis A Vaccine, Hepatitis B Vaccine) ... Hepatitis B vaccine: Why get vaccinated?Hepatitis B vaccine can prevent hepatitis B, and the serious consequences of hepatitis ...

  17. What Is Hepatitis?

    MedlinePLUS

    ... in a more serious disease and worse outcome. Hepatitis B vaccines provide protection from HDV infection. Hepatitis E virus ( ... agaiin Hepatitis infographics Hepatitis A & E pdf, 90kb Hepatitis B, C, D pdf, ... about hepatitis You are here: Features ...

  18. Hepatitis A

    MedlinePLUS

    ... an inflammation of the liver. One type, hepatitis A, is caused by the hepatitis A virus (HAV). The disease spreads through contact with ... washed in untreated water Putting into your mouth a finger or object that came into contact with ...

  19. Hepatitis B

    MedlinePLUS

    ... times more infectious than HIV. Which adults need hepatitis B vaccine? Any sexually active adult who is not in ... share needles, syringes, or other drug-injection equipment. Hepatitis B vaccine is available alone or in a combination with ...

  20. Hepatic Cysts.

    PubMed

    Kaul; Friedenberg; Rothstein

    2000-12-01

    Treatment of hepatic cysts should be considered only for those patients who are symptomatic. For simple cysts, percutaneous aspiration invariably leads to recurrence; laparoscopic deroofing is usually curative. Open deroofing (fenestration) should be reserved for cysts inaccessible by laparoscopy. Percutaneous instillation of sclerosing agents (ethanol, iophendylate, minocycline) into nonbiliary and nonparasitic cysts is an alternative therapeutic option in certain cases. Due to increased morbidity, hepatic resection should be reserved for polycystic liver disease, diffuse hepatic involvement, or recurrence after a deroofing procedure. Patients with congenital fibropolycystic disorders (eg, congenital hepatic fibrosis) with evidence of hepatic decompensation, should be considered for liver transplantation. For hepatic hydatid cysts, simple cystectomy or the PAIR (puncture, aspirate, inject, and reaspirate) technique with albendazole treatment have been shown to be equally successful. In the case of alveolar echinococcosis, hepatic resection and liver transplantation are the only effective modalities for localized and extensive hepatic disease, respectively. PMID:11096603

  1. Autoimmune hepatitis

    MedlinePLUS

    Lupoid hepatitis; Chronic acute liver disease ... This form of hepatitis is an autoimmune disease . The body's immune system cannot tell the difference between healthy body tissue and harmful, outside ...

  2. Hepatic ischemia

    MedlinePLUS

    Hepatic ischemia is a condition in which the liver does not get enough blood or oxygen, causing ... blood pressure from any condition can lead to hepatic ischemia. Such conditions may include: Abnormal heart rhythms ...

  3. [A case of congenital hepatic hemangioendothelioma treated with prednisone: the echographic changes and Doppler study].

    PubMed

    Poggiani, C; Auriemma, A; Bellan, C; Pasinetti, G; Colombo, A

    1998-03-01

    Imaging investigations and other findings observed in a term infant with a multicentric hepatic hemangioendothelioma, admitted to the Intensive Care Unit at the age of 13 days because of non specified feeding difficulties and dyspnoea, are presented. Physical examination revealed cardiac bruit and congestive heart failure with marked hepatomegaly; in addition there were multiple small skin hemangiomas. Echocardiography was negative, abdominal sonography showed multiple round lesions of mixed echogenicity in the liver, large vascular channels, a right hepatic artery and hepatic veins enlarged, a caliber of the aorta below the level of the superior mesenteric artery reduced. The infant was additionally investigated by whole-body scintigraphy with 99mTc-labeled red blood cells to determine the possibility of coexistence of other visceral hemangiomas and by MR, in which the tumor manifested as multiple well-circumscribed space-occupying nodules of high signal intensity on T2-weighted images with evidence of fast flow. The baby underwent furosemide and steroid therapy: serial two-dimensional US scans showed change in echogenicity, responding to therapy. Doppler sonography has proven to be also very useful in the monitoring therapy determining changes in flow pattern and velocity at the level of hepatic, cerebral and renal vessels: before therapy we observed a reduction of the diastolic flow until the zero line through the internal carotid artery and renal artery with an increase of the Resistance Index. It means that this important component can be compromised in the presence of a hepatic hemangioendothelioma. PMID:9676104

  4. Giant Axonal Neuropathy

    MedlinePLUS

    NINDS Giant Axonal Neuropathy Information Page Table of Contents (click to jump to sections) What is Giant Axonal Neuropathy? Is there any treatment? ... being done? Clinical Trials What is Giant Axonal Neuropathy? Giant axonal neuropathy (GAN) is a rare inherited ...

  5. Dynamic gadolinium-DOTA-enhanced MR imaging at 1.0 T. Value in the differentiation of hepatic tumors.

    PubMed

    Soyer, P; Laissy, J P; Sibert, A; Menu, Y

    1996-01-01

    A prospective study was performed to determine the value of dynamic gadolinium-tetraazacyclododecane-tetraacetic acid (Gd-DOTA)-enhanced magnetic resonance (MR) imaging at 1.0 T, using a gradient-echo (GRE) technique, in the differentiation of hepatic tumors. Fifty patients with hemangiomas (n = 14), focal nodular hyperplasia (n = 4), and malignant tumors of the liver (n = 32) underwent GRE MR imaging at 1.0 T before and repeatedly for 4 minutes after intravenous bolus administration of Gd-DOTA. The diagnoses were proved by histology or follow-up examination. On unenhanced GRE images, hemangiomas had a significantly lower tumor-to-liver contrast-to-noise (C/N) ratio (-14.74 +/- 4.49) than did the other tumors (-6.96 +/- 5.49) (p < 0.02), and benign tumors had a significantly lower C/N ratio (-12.43 +/- 5.99) than did malignant tumors (-7.29 +/- 5.71) (p < 0.05). On contrast-enhanced images, hemangiomas had a significantly lower C/N ratio (-17.60 +/- 6.90) than did the other tumors (-5.07 +/- 12.12) (p < 0.05) in the early phase. During the delayed phase, hemangiomas had a significantly higher C/N ratio (3.90 +/- 3.81) than did the other tumors (-4.85 +/- 6.51) (p < 0.01), and benign tumors had a significantly higher C/N ratio (3.21 +/- 3.65) than did malignant tumors (-5.56 +/- 6.56) (p < 0.001). Our data suggest that dynamic Gd-DOTA-enhanced MR imaging at 1.0 T provides useful information to differentiate between benign and malignant hepatic tumors, and to distinguish hemangiomas from the other tumors. PMID:8744821

  6. Low Concentration of Rapamycin Inhibits Hemangioma Endothelial Cell Proliferation, Migration, and Vascular Tumor Formation in Mice

    PubMed Central

    Zheng, Ningning; Ding, Xudong; Jahan, Rabita

    2014-01-01

    Background Vascular endothelial cell excessive proliferation is the main biological behavior of hemangioma. Rapamycin regulates the growth of endothelial cells by inhibiting mammalian target of rapamycin (mTOR). Thus hemangioma accompanied by excessive mTOR activation should be sensitive to rapamycin. We aimed to illustrate the effect of low-concentration rapamycin on hemangioma and provide a safe and effective drug therapy. Methods Mouse hemangioendothelioma endothelial cells and Nu/Nu mice were used. Rapamycin was applied in a concentration from 1 nM to 20 nM. WST-1 cell proliferation and transwell migration assays were used to analyze vascular tumor proliferation and migration in vitro. Xenograft mouse models were used to test vascular tumor growth in vivo. Results Low-concentration rapamycin (1 nM) inhibited hemangioendothelioma endothelial cell proliferation and migration in vitro and vascular tumor growth in vivo. The mechanism was decreased activation of the protein kinase B/mTOR/S6 ribosomal protein (S6) signaling pathway. Conclusions Rapamycin used in vitro was analogous to low serum concentration rapamycin (7–16 nM) and also significantly inhibited the growth of hemangioma. These results demonstrate a low-toxic drug therapy for hemangioma and encourage continued development of rapamycin and its analogs for use in vascular tumor therapy. PMID:25408787

  7. Photodynamic therapy suppresses tumor growth in an in vivo model of human hemangioma.

    PubMed

    Choi, Jaehoon; Kim, Woo Jung; Park, Sang Woo; Xu, Lianji; Kim, Sang-Hyon; Min, Hye Sook; Kwon, Geun-Yong; Cho, Chung-Hyun; Kim, Sukwha; Choi, Tae Hyun

    2014-01-01

    The authors investigated the efficacy of photodynamic therapy against infantile hemangioma using a hemangioma animal model. Eighty-three hemangioma specimens from five children were implanted into nude mice. The gross and volume changes of the implants were evaluated for up to 13 weeks. The histological change of the implant was evaluated at 5 weeks after transplantation. Photodynamic therapy was performed between 6 and 10 weeks after transplantation. The photosensitizer uptake of the implant was evaluated at 24 h after photosensitizer administration. The implant response was evaluated at 0, 12, and 24 h after light delivery. The change in ATF3 levels, a transcription factor induced under severe hypoxic conditions, was investigated immediately after treatment. The implant volume increased slowly during the first 4 weeks and then involuted. At 5 weeks after transplantation, plump endothelial cells formed tightly packed sinusoidal channels, and the endothelial cells were positive for CD31 and GLUT1 expression. At 24 h after photosensitizer administration, confocal analysis showed that the photosensitizer was present within CD31-positive cells. The implant volume was significantly decreased in the treated implants compared with the untreated implants (p < 0.0001). At 24 h after light delivery, most cells had collapsed. ATF3 expression increased gradually and then reached a maximum level at 4 h after treatment. Photodynamic therapy was effective in the treatment of infantile hemangioma. Apoptosis, a major mechanism of hemangioma destruction in the early phase, might be caused by ischemic injury as well as direct effects of photodynamic therapy. PMID:23784382

  8. Intradural extramedullary capillary hemangioma of the cauda equina: Case report and literature review

    PubMed Central

    Liu, Jonathan J.; Lee, Darrin J.; Jin, Lee-Way; Kim, Kee D.

    2015-01-01

    Background: Capillary hemangiomas are benign vascular tumors that rarely occur in the neuraxis. When encountered in the spine, prompt diagnosis and complete resection is crucial. On rare instances, these lesions can acutely hemorrhage, leading to sudden neurological decline. To date, there are only 16 reported cases of intradural capillary hemangiomas in the cauda equina. Case Description: We report a case of an intradural extramedullary cauda equina capillary hemangioma that resulted in back pain and lower extremity motor deficit. Initial magnetic resonance (MR) imaging demonstrated a bilobular intradural L3-4 cauda equina lesion. The lesion was isointense on T1-weighted imaging, mildly hyperintense on T2-weighted images and avidly enhancing after gadolinium administration. Pathology confirmed the diagnosis of capillary hemangioma. Conclusion: Early diagnosis and treatment of this patient resulted in complete resection of the tumor and return of lower extremity motor function. Capillary hemangiomas should be considered in the differential diagnosis of cauda equina lesions. En bloc resection of these lesions is the mainstay of treatment. PMID:25949855

  9. Cellular markers that distinguish the phases of hemangioma during infancy and childhood.

    PubMed Central

    Takahashi, K; Mulliken, J B; Kozakewich, H P; Rogers, R A; Folkman, J; Ezekowitz, R A

    1994-01-01

    Hemangiomas, localized tumors of blood vessels, appear in approximately 10-12% of Caucasian infants. These lesions are characterized by a rapid proliferation of capillaries for the first year (proliferating phase), followed by slow, inevitable, regression of the tumor over the ensuing 1-5 yr (involuting phase), and continual improvement until 6-12 yr of age (involuted phase). To delineate the clinically observed growth phases of hemangiomas at a cellular level, we undertook an immunohistochemical analysis using nine independent markers. The proliferating phase was defined by high expression of proliferating cell nuclear antigen, type IV collagenase, and vascular endothelial growth factor. Elevated expression of the tissue inhibitor of metalloproteinase, TIMP 1, an inhibitor of new blood vessel formation, was observed exclusively in the involuting phase. High expression of basic fibroblast growth factor (bFGF) and urokinase was present in the proliferating and involuting phases. There was coexpression of bFGF and endothelial phenotypic markers CD31 and von Willebrand factor in the proliferating phase. These results provide an objective basis for staging hemangiomas and may be used to evaluate pharmacological agents, such as corticosteroids and interferon alfa-2a, which accelerate regression of hemangiomas. By contrast, vascular malformations do not express proliferating cell nuclear antigen, vascular endothelial growth factor, bFGF, type IV collagenase, and urokinase. These data demonstrate immunohistochemical differences between proliferating hemangiomas and vascular malformations which reflect the biological distinctions between these vascular lesions. Images PMID:7911127

  10. Propranolol represses infantile hemangioma cell growth through the ?2-adrenergic receptor in a HIF-1?-dependent manner.

    PubMed

    Li, Peng; Guo, Zhengtuan; Gao, Ya; Pan, Weikang

    2015-06-01

    Propranolol, as a non-selective blocker of the ?-adrenergic receptor (AR), is utilised as the ?rst-line treatment for infantile hemangiomas. However, the underlying mechanism remains poorly understood. The present study was designed to investigate the molecular basis of propranolol on the regression of infantile hemangiomas using a proliferating infantile hemangioma-derived endothelial cell line. In infantile hemangioma patients, we found that propranolol significantly decreased the expression levels of the hypoxia inducible factor (HIF)-1? in serum and urine, as well as in hemangioma tissues. In vitro analysis revealed that propranolol reduces the expression of HIF-1? in hemangioma cells in a dose- and time-dependent manner, mainly by acting on ?2-AR. Interestingly, it was observed that overexpression of HIF-1? apparently abrogated the inhibitory effects of propranolol on vascular endothelial growth factor (VEGF) expression and cell growth. Our data further demonstrated that propranolol inhibited the signal transducer and activator of transcription 3 (STAT3), a critical oncogenic signaling molecule, and the anti-apoptotic protein Bcl-2. Additionally, overexpression of HIF-1? significantly reversed the inhibitory effects of propranolol on STAT3 signaling. In a mouse xenograft hemangioma model, overexpression of HIF-1? significantly attenuated the therapeutic effects of propranolol and inhibited propranolol-induced hemangioma cell apoptosis. Moreover, the protein levels of VEGF, phosphorylated STAT3, total STAT3 and Bcl-2 were significantly upregulated by HIF-1? overexpression in propranolol-treated nude mice bearing hemangiomas. Collectively, our data provide evidence that propranolol may regress infantile hemangiomas by suppressing VEGF and STAT3 signaling pathways in an HIF-1?-dependent manner. PMID:25872592

  11. Endoscopic bimanual approach to an intraconal cavernous hemangioma of the orbital apex with vascularized flap reconstruction.

    PubMed

    Healy, David Y; Lee, N Grace; Freitag, Suzanne K; Bleier, Benjamin S

    2014-01-01

    The aim of this study was to describe a transnasal endoscopic bimanual technique for the removal of an intraconal orbital apex cavernous hemangioma. Report of a surgical technique. A 39-year-old woman with unilateral visual loss and proptosis was found to have an intraconal orbital apex mass consistent radiographically with cavernous hemangioma. Because of its posteromedial location within the orbit, a transnasal 4-handed endoscopic technique was used with pedicled nasoseptal flap reconstruction. The tumor was excised, and the patient had no complications. The transnasal endoscopic approach to orbital apex cavernous hemangioma excision is a viable surgical approach for these difficult to access lesions. The medial orbital wall may be simultaneously reconstructed to prevent diplopia and enophthalmos. PMID:24833438

  12. Mast cells in canine cutaneous hemangioma, hemangiosarcoma and mammary tumors.

    PubMed

    Woldemeskel, Moges; Rajeev, Sreekumari

    2010-02-01

    Mast cell count (MCC) in 45 dogs with cutaneous hemangioma (HA, n = 12), hemangiosarcoma (HSA, n = 12), mammary adenoma (AD, n = 9) and mammary adenocarcinoma (AC, n = 12) was made using Toluidine blue stained sections. Antibodies against endothelial cell markers, Factor VIII and VEGF were used to visualize and determine the hot spot micro-vessel density (MVD). Total MCC and MCC along the invasive edges were significantly higher (p < 0.001) in canine mammary AC than in AD. The total MCC did not significantly differ (p > 0.05), in HSAs (8.6 +/- 3.3) than in HAs (5.5 +/- 2.8). There is a positive correlation (r = 0.14) between the hot spot MCC and MVD in mammary AC, although not significant (p = 0.3172), indicating that mast cells are associated with angiogenesis in canine mammary AC. This study suggests that mast cells may play an important role in neovascularization of canine cutaneous vascular and mammary neoplasms. Detailed studies encompassing correlation of MCC and MVD with clinical outcomes and prognosis in these neoplasms are recommended. PMID:20127412

  13. Benign hepatic tumours and tumour like conditions in men.

    PubMed Central

    Karhunen, P J

    1986-01-01

    In a consecutive medicolegal necropsy series benign hepatic tumours and tumour like conditions occurred in 52% of the 95 men aged 35-69 years. The incidence increased with age, mainly due to small bile duct tumours (n = 26; mean age 56.7 years; p less than 0.01; mean size 1.3 mm). The next most common tumours were cavernous hemangiomas (n = 19; mean age 53.9 years; mean size 5.2 mm) that were not related to age. Focal nodular hyperplasia (n = 3; mean size 8.0 mm) tended to occur in a younger age group (mean age 40.3 years; p less than 0.001). Multiple bile duct tumours were present in 46% and hemangiomas in 50% of the men studied. Liver cell adenoma, nodular regenerative hyperplasia, and peliosis hepatis were incidental findings (one case of each). Nodular regenerative hyperplasia was associated with the consumption of alcohol and a total dose of 21.5 g of testosterone. These results indicate that benign hepatic tumours and tumour like conditions are not rare in men but may remain undetected because of their small size. Images PMID:3950039

  14. Hemangioma of the Tympanic Membrane: A Case and a Review of the Literature

    PubMed Central

    Mevio, Emilio; Cazzaniga, Marco; Mullace, Mauro; Paolotti, Donatella

    2012-01-01

    Hemangiomas of the external auditory canal, involving the posterior bony canal and the adjacent tympanic membrane, although rare, are considered a specific disease entity of the human external auditory canal. Hemangiomas of the tympanic membrane and/or external auditory canal are rare entities; there are 16 previous case reports in the literature. It is a benign vascular tumor. It generally occurs in males in the sixth decade of life. Total surgical excision with or without tympanic membrane grafting appears to be effective in the removal of this benign neoplasm. The authors present a case and a review of the literature discussing diagnostic and surgical approaches. PMID:23243539

  15. Recurrent targetoid hemosiderotic hemangioma in a 26-year-old man.

    PubMed

    Gendernalik, Sarah Broski; Gendernalik, James D

    2011-02-01

    A 26-year-old previously healthy man presented with a 6-mm violaceous papule that had a surrounding 1.5-cm annular, nonblanching, erythematous halo on the right-sided flank. The man reported the lesion had been recurring for 4 to 5 years, flaring every 4 to 5 months and then slowly disappearing until the cycle recurred. Targetoid hemosiderotic hemangioma was clinically diagnosed. The lesion was removed by means of elliptical excision and the condition resolved. The authors discuss the clinical appearance, histology, and etiology of targetoid hemosiderotic hemangiomas. PMID:21357498

  16. [Sclerosing hemangioma of the lung: a rare lesion with a difficult diagnosis].

    PubMed

    Bougrine, F; Chouchane, O; Doghri, R; Znaidi, N; Hchicha, S; Sakhri, A; Laabidi, B; Cheikh, R; Chnik, S; Bouziani, A

    2006-12-01

    Sclerosing hemangioma of the lung is a rare lesion described for the first time in 1956 by Liebow. We report a case in a 45 year-old woman who was admitted for exploration of chronic cough. The chest x-ray revealed a round opacity, well delimited in the left pulmonary parenchyma. Surgical resection enabled the histopathological diagnosis of sclerosing hemangioma. We review progress in our knowledge of the histogenesis and diagnosis of this tumor. Immunohistochemistry has been highly contributory although numerous points remain controversial. PMID:17242645

  17. Adolescent With 68Ga DOTATATE-Avid Vertebral Hemangioma Mimicking Metastasis in PET Imaging.

    PubMed

    Skoura, Evangelia; Alshammari, Alshaima; Syed, Rizwan; Sajjan, Rakesh; Bomanji, Jamshed

    2015-07-01

    Ga DOTATATE PET/CT is a well-established method in the diagnostic workup of neuroendocrine tumors. We report the case of a 15-year-old adolescent boy with histologically proven appendiceal carcinoid tumor referred for Ga DOTATATE PET/CT to identify residual or metastatic disease. PET images showed increased tracer uptake in the body of T4 vertebra. This uptake could be misdiagnosed for bone metastasis, but CT characteristic appearance was in keeping with vertebral hemangioma. Both bone metastasis in carcinoid tumor and bone hemangiomas in adolescents are rare conditions, but the combined metabolic and morphological information on PET/CT can lead to the correct diagnosis. PMID:25783517

  18. Multifocal osteolytic lesions of the skull: a primary cavernous hemangioma mimicking a neoplastic invasive lesion.

    PubMed

    Hsiao, I-Han; Cho, Der-Yang; Liu, Chun-Lin

    2015-06-01

    Intraosseous cavernous hemangioma is a rare cause of osteolytic lesions of the skull, and its multifocal type is even more infrequent. This tumor is difficult to accurately diagnose by imaging and can be confused with osteolytic Langerhan's cell histiocytosis or other neoplasms. Here we present a case of multifocal intraosseous cavernous hemangioma of the skull treated with surgical intervention in our hospital five years ago. A review of related literatures and case reports is also provided to help clarify the diagnosis and devise treatment regimens. In light of the difficulties of early diagnosis, early en bloc surgical removal is recommended. PMID:26054903

  19. Diagnosis and management of hepatic focal nodular hyperplasia.

    PubMed

    Venturi, A; Piscaglia, F; Vidili, G; Flori, S; Righini, R; Golfieri, R; Bolondi, L

    2007-09-01

    Focal nodular hyperplasia (FNH) is the second most common benign tumor of the liver, after hemangioma. It is generally found incidentally and is most common in reproductive-aged women, but it also affects males and can be diagnosed at any age. Patients are rarely symptomatic, but FNH sometimes causes epigastric or right upper quadrant pain. The main clinical task is to differentiate it from other hypervascular hepatic lesions such as hepatic adenoma, hepatocellular carcinoma, or hypervascular metastases, but invasive diagnostic procedures can generally be avoided with the appropriate use of imaging techniques. Magnetic resonance (MR) imaging is more sensitive and specific than conventional ultrasonography (US) or computed tomography (CT), but Doppler US and contrast-enhanced US (CEUS) can greatly improve the accuracy in the diagnosis of FNH. Once a correct diagnosis has been made, in most cases there is no indication for surgery, and treatment includes conservative clinical follow-up in asymptomatic patients. PMID:23396642

  20. Hepatitis C Test

    MedlinePLUS

    ... Hepatitis C Antibody; Anti-HCV; HCV-PCR; HCV-RNA; Hepatitis C Viral Load Formal name: Viral Hepatitis C Antibody Screen; Viral Hepatitis C RNA by PCR; Hepatitis C Virus Genotype Related tests: ...

  1. Hepatitis virus panel

    MedlinePLUS

    Hepatitis A antibody test; Hepatitis B antibody test; Hepatitis C antibody test; Hepatitis D antibody test ... others through sexual contact or by sharing needles Antibodies to hepatitis C can usually be detected 4 - 10 weeks after ...

  2. Differentiation between hemangiomas and hepatocellular carcinomas with the apparent diffusion coefficient calculated from turboFLASH MR images.

    PubMed

    Moteki, T; Ishizaka, H; Horikoshi, H; Matsumoto, M

    1995-01-01

    Serial turboFLASH (fast low-angle shot) images with and without diffusion-perfusion (DP) gradients were used for the evaluation of and differentiation between hemangiomas and hepatocellular carcinomas (HCCs) of the liver. Twenty-six patients with 27 hemangiomas, and 19 patients with 21 HCCs were studied. T1- and T2-weighted spin-echo images, serial turboFLASH images with and without DP gradients (b = 294.8 and 0 sec/mm2, respectively) were obtained, and the apparent diffusion coefficient (ADC) was calculated for all lesions. Hemangiomas were detected as well-defined areas of decreased signal intensity on turboFLASH images obtained with DP gradients; HCCs showed slight or no obvious decrease in signal intensity on serial turboFLASH images obtained with DP gradients compared with turboFLASH images obtained without DP gradients, while a considerable percentage (76.5%) of nodular HCCs showed an obvious decrease in signal intensity at the margins. Hemangiomas had large ADC values compared with HCCs. Both ADC and T2 values were significantly different between hemangiomas and HCCs (P < .01). However, there was no obvious correlation between ADC and T2 values for either hemangiomas or HCCs (r = .18 and .48, respectively). On the basis of these results, the calculated ADC should be helpful for distinguishing hemangiomas from HCCs, and the ADC values may be useful even when T2 values are not helpful for making the distinction. PMID:7766981

  3. How Airway Venous Malformations Differ From Airway Infantile Hemangiomas

    PubMed Central

    Parhizkar, Nooshin; Manning, Scott C.; Inglis, Andrew F.; Finn, Laura S.; Chen, Eunice Y.; Perkins, Jonathan A.

    2013-01-01

    Objective To compare airway infantile hemangiomas (IHs) and venous malformations (VMs) clinically, radiographically, endoscopically, and histologically. Design Retrospective cohort study. Setting Tertiary care pediatric hospital. Patients The study included patients seen in the Vascular Anomaly Clinic, Seattle Children’s Hospital, Seattle, Washington, between 2001 and 2008. Methods All patients with airway vascular anomalies were identified by searching the Vascular Anomaly Quality Improvement Database and hospital discharge data. The data, which were analyzed with descriptive statistics and the Fisher exact test, included presenting age, sex, presenting signs, lesion site, and radiographic, endoscopic, and histologic findings.. Results Seventeen patients with airway lesions were identified, 6 with VMs and 11 with IHs. Patients with VMs presented at a mean (SD) age of 11.3 (13.7) months (age range, 3–39 months), while those with IHs presented at 3 (1.8) months of age (age range, 1–6 months) (P =.03). The patients with IHs were predominantly female (9 of 11 [81%]), while no sex difference was noted among the patients with VMs (3 of 6 [50%]). All patients with IHs presented with stridor and cutaneous lesions, whereas patients with VMs more often presented with hemoptysis or dysphagia (P = .001). Computed tomographic angiograms demonstrated enhancing endolaryngeal lesions in all IHs, while VMs enhanced poorly. Endoscopically, IHs were transglottic, while VMs were postcricoid or epiglottic (P <.001). Histologically, immunostained lesions showed submucosal lobules of capillaries lined by GLUT-1 (glucose transporter isoform 1)–positive endothelium in IHs, whereas VMs consisted of loosely organized venous channels that lacked GLUT-1 staining. Conclusion Patients with airway IHs and VMs differ in presenting age and signs, sex, airway lesion location, enhancement on computed tomographic angiograms, and histologic appearance. PMID:21242531

  4. A mixed neoplasm of intraosseous hemangioma with an ameloblastoma: a case of collision tumor or a rare variant?

    PubMed Central

    Jois, Harshvardhan S.; Kumar K.P., Mohan; Kumar, Mandali Satish; Waghrey, Shefali

    2011-01-01

    Hemangiomas of the head and neck are considered to be benign tumors of infancy that are characterized by a rapid growth phase with endothelial cell proliferation, followed by gradual involution. Central hemangiomas are a rare occurrence and even rarer are the hybrid tumors of central hemangiomas with odontogenic tumors such as ameloblastomas. This paper reports a case of one such hybrid tumor in a middle aged adult clinical presenting as a mandibular swelling with indistinct mixed radiographic presentation and histopathologically comprising of intimately associated hemangiomatous vascular channels and typical ameloblastic areas. To the authors' knowledge this is the sixth case of such a hemangiomatous ameloblastoma which has been reported till date. PMID:24765404

  5. Clinicopathological and Ultrastructural Study of Multiple Lobular Capillary Hemangioma after Scalding

    Microsoft Academic Search

    Wen-Jun Liao; Ping-Shen Fan; Meng Fu; Tian-Wen Gao; Yu-Feng Liu; Shigaku Ikeda

    2006-01-01

    We herein report 2 cases of multiple lobular capillary hemangiomas after scalding. The patients exhibited papules and nodules on the scalded areas after healing. Histopathological examination of the lesions showed capillary proliferation in the upper dermis with edematous stroma containing inflammatory infiltrates predominantly composed of neutrophils. Biopsy tissue and secretion specimens from lesions of case 1 were cultured for bacteria,

  6. Delayed-onset of multiple cutaneous infantile hemangiomas due to propranolol: a case report.

    PubMed

    Porcel Chacón, Rocío; del Boz González, Javier; Navarro Morón, Juan

    2015-04-01

    Infantile hemangiomas are the most common vascular tumors in childhood. In view of its proven effectiveness in such cases, propranolol is the drug of choice. We present the case of a male infant who started treatment with propranolol shortly after birth due to heart disease. After 7 months, when the patient had suffered various respiratory exacerbations, this treatment was suspended. One week later, multiple skin lesions (ie, multifocal infantile hemangiomas) began to appear, with no extracutaneous involvement. It was decided to resume treatment with propranolol, although at lower doses than before, and the skin lesions improved rapidly, with some disappearing completely. Treatment was definitively withdrawn at age 16 months, with only slight recurrence of the lesions. The case described is of multifocal infantile hemangiomas without extracutaneous involvement appearing beyond the neonatal period after treatment with propranolol beginning in the first days of life. The details of the case support the hypothesis that this drug is not only therapeutic but also plays a prophylactic role against infantile hemangiomas. In turn, this supports the recent proposal that this drug may be useful in preventing the growth and spread of tumors with high angiogenic potential. It is postulated that the inhibition of ?-adrenergic receptors is associated with multiple intracellular processes related to the progression and metastasis of different tumors. PMID:25780066

  7. Choroidal thickness changes with photodynamic therapy for a diffuse choroidal hemangioma in Sturge–Weber syndrome.

    PubMed

    Cacciamani, Andrea; Scarinci, Fabio; Parravano, Mariacristina; Giorno, Paola; Varano, Monica

    2014-10-01

    The aim of this study was to evaluate the choroidal thickness (CT) changes associated with visual function following photodynamic therapy (PDT) for a diffuse choroidal hemangioma in Sturge–Weber syndrome. We report a case of Sturge–Weber syndrome and symptomatic serous retinal detachment (SRD) with diffuse choroidal hemangioma treated with PDT. Visual acuity (VA), macular sensitivity measured by means of MP1 microperimeter (Nidek Technologies, Padova, Italy), retinal and CT, measured by means of enhanced depth optical coherence tomography (EDI–OCT, Spectralis, Heidelberg Engineering, Heidelberg, Germany) were analyzed at baseline, 3 and 12 months follow-up.After the PDT VA and macular sensitivity improved.The OCT examination showed the resolution of SRD. The choroid was measured after PDT using EDI–OCT. At baseline, the subfoveal CT showed a progressive thickness reduction from 251 to 83 lm during follow-up. To our knowledge, this is the first report of CT changes after PDT for a diffuse choroidal hemangioma in Sturge–Weber syndrome in a longterm follow-up. The CT measurement represents a potential parameter to better follow choroidal hemangiomas and their response to treatment. However,the long-term choroidal changes should be carefully taken into account. PMID:24658736

  8. Minimal invasive method to treat hemangiomas of the oral cavity with a CO2 laser

    NASA Astrophysics Data System (ADS)

    Nicola, Ester M. D.; Nicola, Jorge H.; Gusmao, Reinaldo J.; Coutinho, Adriana A.; Cassitas, Nilceu P.

    1997-05-01

    During the last six years we have developed a new CO2 laser technique for the treatment of symptomatic oral cavity hemangioma. Our new technique, named 'laser encircling technique', has especially succeeded during hemangioma buccal maxillary surgeries. The treatment consisted in the application of a line of points of CO2 laser circling the lesion. Depending on the position and size of the lesion, we used from 0.4 to 4.0 Joules/mm2 laser energy density per pulse, causing reduction in the size of the lesion throughout the sclerosis of nutritional vessels which led to reduction in size, volume and color of the hemangiomas with no significant bleeding or inflammatory reaction. In this work forty male and female patients, twelve to fifty years old, presenting medium to small size hemangiomas situated in different sites of the oral cavity such as the tongue, mouth vestibule, pharynx, tonsil area and lips were treated by the procedure described above. The number of laser applications was defined by the peculiarities of each case, varying form 3 to 6 sessions at 4 week intervals, always under local or topic anesthesia. The patients complained about minimal posit operative discomfort and had good cicatrix evolution. The good results achieved by this technique lead to the conclusion that CO2 laser for these types of hemangioma is an efficient and very secure method of treatment. An important aspect of our technique is the fact that using relatively low laser power we do not perform real surgery but a less aggressive alternative of treatment.

  9. Hepatic dysfunction.

    PubMed

    McCord, Kelly W; Webb, Craig B

    2011-07-01

    This article reviews the common pathophysiology that constitutes hepatic dysfunction, regardless of the inciting cause. The systemic consequences of liver failure and the impact of this condition on other organ systems are highlighted. The diagnostic tests available for determining the cause and extent of liver dysfunction are outlined, treatment strategies aimed at supporting hepatic health and recovery are discussed, and prognosis is briefly covered. The article emphasizes the fact that because of the central role of the liver in maintaining normal systemic homeostasis, hepatic dysfunction cannot be effectively addressed as an isolated entity. PMID:21757090

  10. Hepatic Encephalopathy

    PubMed Central

    Bleibel, Wissam; Al-Osaimi, Abdullah M. S.

    2012-01-01

    Chronic liver disease and cirrhosis affect hundreds of millions of patients all over the world. The majority of patients with cirrhosis will eventually develop complications related to portal hypertension. One of these recurrent and difficult to treat complications is hepatic encephalopathy. Studies have indicated that overt hepatic encephalopathy affects 30 to 45% of patients with cirrhosis and a higher percentage may be affected by minimal degree of encephalopathy. All of these factors add to the impact of hepatic encephalopathy on the healthcare system and presents a major challenge to the gastroenterologist, hospitalist and primary care physician. PMID:23006457

  11. Hypoplastic extraocular muscles due to sclerosing cavernous hemangioma of the cavernous sinus mimicking congenital fibrosis of the extraocular muscles

    PubMed Central

    Leon, Bhambi Gesite-de; Demer, Joseph L.

    2014-01-01

    A girl with a clinical presentation consistent with unilateral congenital fibrosis of the extraocular muscles type 3 at 2 years of age years later developed progressive ophthalmoplegia and an afferent pupillary defect. Reimaging revealed a lesion diagnosed as a sclerosing cavernous sinus hemangioma with focal calcification. Cavernous sinus hemangioma is a rare, benign vascular malformation whose growth causes cranial nerve compression. Although frequently missed on routine neuroimaging, characteristic radiologic findings distinguish it from lesions such as meningioma. PMID:24751811

  12. Hepatitis A

    MedlinePLUS

    ... Less commonly, viral infections such as mononucleosis or cytomegalovirus can cause hepatitis. There are 2 main kinds ... urine Loss of appetite Muscle pain Itching Young children are likely to have very mild cases of ...

  13. Hepatic Encephalopathy

    MedlinePLUS Videos and Cool Tools

    ... is a condition that causes temporary worsening of brain function in people with advanced liver disease. When ... travel through your body until they reach your brain, causing mental and physical symptoms of HE. Hepatic ...

  14. Hepatitis A.

    PubMed

    Matheny, Samuel C; Kingery, Joe E

    2012-12-01

    Hepatitis A is a common viral illness worldwide, although the incidence in the United States has diminished in recent years as a result of extended immunization practices. Hepatitis A virus is transmitted through fecal-oral contamination, and there are occasional outbreaks through food sources. Young children are usually asymptomatic, although the likelihood of symptoms tends to increase with age. Most patients recover within two months of infection, although 10 to 15 percent of patients will experience a relapse in the first six months. Hepatitis A virus does not usually result in chronic infection or chronic liver disease. Supportive care is the mainstay of treatment. The Centers for Disease Control and Prevention and the American Academy of Pediatrics recommend routine vaccination of all children 12 to 23 months of age, as well as certain vulnerable populations. Hepatitis A vaccine is also recommended for most cases of postexposure prophylaxis, although immunoglobulin is an acceptable alternative in some situations. PMID:23198670

  15. Autoimmune hepatitis

    Microsoft Academic Search

    Diego Vergani; Maria Serena Longhi; Dimitrios P. Bogdanos; Yun Ma; Giorgina Mieli-Vergani

    2009-01-01

    Autoimmune hepatitis (AIH) is an inflammatory liver disease affecting mainly females and characterised histologically by interface\\u000a hepatitis, biochemically by elevated transaminase levels and serologically by the presence of autoantibodies and increased\\u000a levels of immunoglobulin G. AIH responds to immunosuppressive treatment, which should be instituted as soon as diagnosis is\\u000a made. Seropositivity for smooth muscle and\\/or anti-nuclear antibody defines type 1

  16. Feature Hepatitis: Hepatitis Symptoms, Diagnosis, Treatment & Prevention

    MedlinePLUS

    ... Navigation Bar Home Current Issue Past Issues Feature Hepatitis Hepatitis: Symptoms, Diagnosis, Treatment & Prevention Past Issues / Spring 2009 ... No appetite Fever Headaches Diagnosis To check for hepatitis viruses, your doctor will test your blood. You ...

  17. Klippel-Trenaunay and Sturge-Weber syndromes with renal hemangioma and double inferior vena cava.

    PubMed

    Schofield, D; Zaatari, G S; Gay, B B

    1986-08-01

    We describe a 3 1/2-year-old boy with the Klippel-Trenaunay and Sturge-Weber syndromes. The child had congenital superficial capillary hemangiomas, congenital glaucoma and mild hydrocephalus. During the first year of life he experienced intermittent hematuria. When he was 3 years old he presented with seizures and left hemihypertrophy first was noted. Several months later radiological examination of a large abdominal mass demonstrated its origin to be in the right kidney. Radical nephrectomy documented the presence of renal hemangioma with complicating perirenal hematoma. A double inferior vena cava was another unexpected surgical finding that complicated the course of this patient. All of these unusual features in these rare syndromes with their clinical, pathogenetic and therapeutic implications are discussed. The differential diagnosis of renal masses in these syndromes also is presented. PMID:3016342

  18. Photodynamic therapy for diffuse choroidal hemangioma in sturge-weber syndrome.

    PubMed

    Monteiro, Sílvia; Casal, Inês; Santos, Marinho; Meireles, Angelina

    2014-01-01

    Purpose. To report the treatment outcome of photodynamic therapy with verteporfin (PDT) for exudative retinal detachment (RD) associated with diffuse choroidal hemangioma in Sturge-Weber syndrome (SWS). Methods. An interventional case report of a 10-year-old girl with SWS who developed an exudative RD (visual acuity hand motions) that was treated with PDT. She was treated with a first session of multispot PDT. Posteriorly, a choroidotomy for drainage of subretinal fluid was created, combined with an intravitreal injection of gas (SF6) and cryoapplication. Finally, a second session of PDT was applied. Results. Subretinal fluid resolved over a period of one year and visual acuity increased to 20/125. Conclusions. PDT is an effective therapeutic option for exudative RD associated with diffuse choroidal hemangioma. PMID:24955093

  19. Photodynamic Therapy for Diffuse Choroidal Hemangioma in Sturge-Weber Syndrome

    PubMed Central

    Monteiro, Sílvia; Casal, Inês; Santos, Marinho

    2014-01-01

    Purpose. To report the treatment outcome of photodynamic therapy with verteporfin (PDT) for exudative retinal detachment (RD) associated with diffuse choroidal hemangioma in Sturge-Weber syndrome (SWS). Methods. An interventional case report of a 10-year-old girl with SWS who developed an exudative RD (visual acuity hand motions) that was treated with PDT. She was treated with a first session of multispot PDT. Posteriorly, a choroidotomy for drainage of subretinal fluid was created, combined with an intravitreal injection of gas (SF6) and cryoapplication. Finally, a second session of PDT was applied. Results. Subretinal fluid resolved over a period of one year and visual acuity increased to 20/125. Conclusions. PDT is an effective therapeutic option for exudative RD associated with diffuse choroidal hemangioma. PMID:24955093

  20. [Chronic hepatitis].

    PubMed

    Figueroa Barrios, R

    1995-01-01

    Medical literature about chronic hepatitis is reviewed. This unresolving disease caused by viruses, drugs or unknown factors may progress to in cirrhosis and hepatocarcinoma. A classification based on liver biopsy histology into chronic persistent and chronic active types has been largely abandoned and emphasis is placed on recognizing the etiology of the various types. One is associated with continuing hepatitis B virus infection; another is related to chronic hepatitis C virus infection and the third is termed autoinmune, because of the association with positive serum autoantibodies. A fourth type with similar clinical functional and morphologic features is found with some drug reactions. Long term corticoesteroid therapy is usually successful in autoinmune type. Associations between antibodies to liver-kidney microsomes and the hepatitis C virus can cause diagnostic difficulties. Antiviral treatment of chronic hepatitis B and C with interpheron alfa is employed, controlling symptoms and abnormal biochemistry and the progression to cirrhosis and liver cancer in 30 to 40% patients. Alternative therapies or combinations with interpheron are being evaluated waiting for final results. PMID:8520023

  1. [Involvement of splenic hemangioma and rectal varices in a patient with klippel: trenaunay syndrome].

    PubMed

    Choi, Youn Jung; Jee, Sam Ryong; Park, Kwan Sik; Ryu, Choong Heon; Seo, Hyo Rim; Ha, Seoung In; Lee, Sang Heon; Ok, Kyung Sun

    2011-09-25

    Klippel - Trenaunay syndrome (KTS) is characterized by a cutaneous vascular nevus of the involved extremity, bone and soft tissue hypertrophy of the extremity and venous malformations. We present a case of KTS with splenic hemangiomas and rectal varices. A 29-year-old woman was referred for intermittent hematochezia for several years. She had history with a number of operations for cutaneous and soft tissue hamangiomas since the age of one year old and for increased circumference of her left thigh during the last few months. Abdominal CT revealed multiple hemangiomas in the spleen, fusiform aneurysmal dilatation of the deep veins and soft tissue hemangiomas. There was no evidence of hepatosplenomegaly or liver cirrhosis. Colonoscopy revealed hemangiomatous involvement in the rectum. There were rectal varices without evidence of active bleeding. Upon venography of the left leg, we also found infiltrative dilated superficial veins in the subcutaneous tissue and aneurysmal dilatation of the deep veins. The patient was finally diagnosed with KTS, and treated with oral iron supplementation only, which has been tolerable to date. Intervention or surgery is not required. When gastrointestinal varices or hemangiomatous mucosal changes are detected in a young patient without definite underlying cause, KTS should be considered. PMID:21960105

  2. Klippel-Trenaunay syndrome with gastrointestinal bleeding, splenic hemangiomas and left inferior vena cava

    PubMed Central

    Wang, Zhen-Kai; Wang, Fang-Yu; Zhu, Ren-Min; Liu, Jiong

    2010-01-01

    Klippel-Trenaunay syndrome is a congenital vascular anomaly characterized by a triad of varicose veins, cutaneous capillary malformation, and hypertrophy of bone and (or) soft tissue. Gastrointestinal vascular malformations in Klippel-Trenaunay syndrome may present with gastrointestinal bleeding. The majority of patients with spleenic hemangiomatosis and/or left inferior vena cava are asymptomatic. We herein report a case admitted to the gastroenterology clinic with life-threatening hematochezia and symptomatic iron deficiency anemia. Due to the asymptomatic mild intermittent hematochezia, splenic hemangiomas and left inferior vena cava, the patient did not seek any help for gastrointestinal bleeding until his admittance to our department for evaluation of massive gastrointestinal bleeding. He was referred to angiography because of his serious pathogenetic condition and inefficiency of medical therapy. The method showed that hemostasis was successfully achieved in the hemorrhage site by embolism of corresponding vessels. Further endoscopy revealed vascular malformations starting from the stomach to the descending colon. On the other hand, computed tomography revealed splenic hemangiomas and left inferior vena cava. To the best of our knowledge, this is the first Klippel-Trenaunay syndrome case presenting with gastrointestinal bleeding, splenic hemangiomas and left inferior vena cava. The literature on the evaluation and management of this case is reviewed. PMID:20333801

  3. Superior Mesenteric Artery Syndrome due to a Vertebral Hemangioma and Postpartum Osteoporosis following Treatment.

    PubMed

    Elmadag, Mehmet; Güzel, Yunus; Uzer, Gokcer; Tuncay, ?brahim

    2015-01-01

    In pregnancy, advanced vertebral hemangiomas may be seen, and these require treatment. The case reported here is of a 35-year-old female in the 32nd week of pregnancy who was admitted to the orthopaedics clinic with a history of backache and difficulty walking. A burst fracture of L1 associated with a vertebral hemangioma was identified with an L3 compression fracture secondary to osteoporosis. The local kyphosis angle between T12 and L2 was 27°. Kyphotic deformity was corrected and postoperatively, the measured T12-L2 local kyphotic angle was 9°. Twelve hours postoperatively, oral nutrition was allowed, but she developed nausea and vomiting and twenty-four hours postoperatively, an electrolyte imbalance developed. Postoperatively, the patient was diagnosed with superior mesenteric artery syndrome. To the best of our knowledge, this is the first reported case of superior mesenteric artery syndrome, which occurred following the correction of a kyphotic deformity that had developed secondary to an advanced hemangioma in pregnancy. PMID:25685576

  4. Central Retinal and Posterior Ciliary Artery Occlusion After Intralesional Injection of Sclerosant to Glabellar Subcutaneous Hemangioma

    SciTech Connect

    Matsuo, Toshihiko, E-mail: matsuot@cc.okayama-u.ac.j [Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Department of Ophthalmology (Japan); Fujiwara, Hiroyasu; Gobara, Hideo; Mimura, Hidefumi; Kanazawa, Susumu [Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Department of Radiology (Japan)

    2009-03-15

    The aim of this study is to describe vision loss caused by central retinal artery and posterior ciliary artery occlusion as a consequence of sclerotherapy with a polidocanol injection to a glabellar hemangioma. An 18-year-old man underwent direct injection with a 23-gauge needle of 1 mL of a polidocanol-carbon dioxide emulsion into the glabellar subcutaneous hemangioma under ultrasound visualization of the needle tip by radiologists. He developed lid swelling the next day, and 3 days later at referral, the visual acuity in the left eye was no light perception. Funduscopy revealed central retinal artery occlusion and fluorescein angiography disclosed no perfusion at all in the left fundus, indicating concurrent posterior ciliary artery occlusion. The patient also showed mydriasis, blepharoptosis, and total external ophthalmoplegia on the left side. Magnetic resonance imaging demonstrated the swollen medial rectus muscle. In a month, blepharoptosis and ophthalmoplegia resolved but the visual acuity remained no light perception. Sclerosing therapy for facial hemangioma may develop a severe complication such as permanent visual loss.

  5. Successful treatment of oral itraconazole for infantile hemangiomas: a case series.

    PubMed

    Ran, Yuping; Chen, Shuang; Dai, Yalin; Kang, Daoxian; Lama, Jebina; Ran, Xin; Zhuang, Kaiwen

    2015-02-01

    Infantile hemangiomas can present a therapeutic challenge to clinicians, especially when associated with severe pain and feeding difficulties. The standard therapeutic management includes corticosteroids and propranolol. However, the clinical response is not always satisfactory. We present six cases of infantile hemangiomas successfully treated with oral itraconazole approximately 5 mg/kg per day. In the first month, the red color of the lesions became a little lighter and the growth of the lesions was controlled in all cases. An obvious clinical improvement was noted in all cases during the 3-month period, with 80-100% improvement in each patient at the end of the treatment, which was judged by both their parents and the dermatologists. Compliance with treatment instructions of oral itraconazole in infants was judged to be very good. Side-effects were mild and limited. Although itraconazole can inhibit angiogenesis and tumor growth in vitro and in vivo associated with some cancers, further research is required to understand the pathogenesis of infantile hemangiomas and the mechanism of itraconazole. PMID:25512128

  6. Dubin-Johnson syndrome with multiple liver cavernous hemangiomas: report of a familial case.

    PubMed

    Li, Peifeng; Wang, Yingmei; Zhang, Jinmei; Geng, Ming; Li, Zengshan

    2013-01-01

    Dubin-Johnson syndrome (DJS) is a rare autosomal recessive inheritance disorder of bilirubin metabolism. Herein we reported a complicated but interesting case which is readily resulted in misdiagnosis or an indefinite diagnosis, and this is the first reported familial case of DJS with multiple liver cavernous hemangiomas. A 49-year-old man was referred to our hospital for jaundice and multiple low-density liver masses. Extensive laboratory investigations showed conjugated hyperbilirubinaemia and positive urine bilirubin. Microscopically, lesions were composed of blood-filled vascular channels of various sizes lined by a single layer of flat endothelial cells supported by fibrous tissue. Coarse brown granules presented in the hepatocytes of the liver lobules locating beside the tumor, particularly in the centrilobular hepatocytes, and the granules showed blue-green with Schmorl's reaction lipofuscin staining. Interestingly, one of the patient's six siblings (female) shared the same condition with him. The relationship between DJS and hemangiomas remains unclear, and it might be contributed to some hereditary factors, or probably occurred simultaneously by chance. It was certified that the true reason for the long-term unclear jaundice was DJS, which was presumed clinically to be caused by bile excretion obstacles associated with the hemangiomas. Liver biopsy and histochemical stain may be helpful to identify the reason of jaundice and avoid misdiagnosis or an indefinite diagnosis. PMID:24228133

  7. Development and Validation of a Quality-of-Life Instrument for Infantile Hemangiomas.

    PubMed

    Chamlin, Sarah L; Mancini, Anthony J; Lai, Jin-Shei; Beaumont, Jennifer L; Cella, David; Adams, Denise; Drolet, Beth; Baselga, Eulalia; Frieden, Ilona J; Garzon, Maria; Holland, Kristin; Horii, Kimberly A; Lucky, Anne W; McCuaig, Catherine; Metry, Denise; Morel, Kimberly D; Newell, Brandon D; Nopper, Amy J; Powell, Julie; Siegel, Dawn; Haggstrom, Anita N

    2015-06-01

    Infantile hemangiomas (IH) are common tumors for which there is no validated disease-specific instrument to measure the quality of life in infants and their parents/caregivers during the critical first months of life. This study prospectively developed and validated a quality-of-life instrument for patients with IH and their parents/caregivers and correlated demographic and clinical features to the effects on the quality of life. A total of 220 parents/caregivers completed the 35-item Infantile Hemangioma Quality-of-Life (IH-QoL) instrument and provided demographic information. The dimensionality of the items was evaluated using factor analysis, with results suggesting four factors: child physical symptoms, child social interactions, parent emotional functioning, and parent psychosocial functioning. Each factor fit the Rasch measurement model with acceptable fit index (mean square <1.4) and demonstrated excellent internal consistency, with alpha ranging from 0.76 to 0.88. The final instrument consists of four scales with a total of 29 items. Content validity was verified by analyzing parents' responses to an open-ended question. Test-retest reliability at a 48-hour interval was supported by a total IH-QoL intraclass correlation coefficient of 0.84. Certain clinical characteristics of hemangioma, including those located on the head and neck, in the proliferative stage, and requiring treatment, are associated with a greater impact on QoL. PMID:25615551

  8. Mistletoe hepatitis.

    PubMed Central

    Harvey, J; Colin-Jones, D G

    1981-01-01

    A 49-year-old woman presented with nausea, general malaise, and a dull ache in the right hypochondrium. Liver biopsy showed slight inflammatory-cell infiltration, and results of liver function tests suggested hepatitis. Hepatitis B surface antigen was not detected, and a cholecystogram was normal. Two years later she presented with similar symptoms, and both illnesses were found to have occurred after ingestion of a herbal remedy containing kelp, motherwort, skullcap, and mistletoe. A challenge test established this to be the cause of the illness. Mistletoe is the only constituent of the tablets known to contain any potential toxin and thus was probably the cause of the illness. Mistletoe is widely used in herbal remedies, whose ingestion may therefore cause hepatitis. Images FIG 1 FIG 2 PMID:6779941

  9. Hepatitis C

    NSDL National Science Digital Library

    Patient Education Institute

    This patient education program explains Hepatitis C, the liver and Hepatitis, symptoms, diagnosis, treatment, risk factors, and prevention. This is a MedlinePlus Interactive Health Tutorial from the National Library of Medicine, designed and developed by the Patient Education Institute. NOTE: The tutorial requires a special Flash plug-in, version 4 or above. If you do not have Flash, you will be prompted to obtain a free download of the software before you start the tutorial. You will also need an Acrobat Reader, available as a free download, in order to view the Reference Summary.

  10. Complete genome sequence of an avian leukosis virus isolate associated with hemangioma and myeloid leukosis in egg-type and meat-type chickens

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A new virus isolate was separated from a commercial egg-type flock of chickens in China and was determined as subgroup J avian leukosis virus (ALV-J). ALV-J is known to cause myeloid leukosis. But this new isolate of viruses causes both hemangioma and myeloid leukosis in chickens. Hemangioma is an a...

  11. [Neoplastic space-occupying lesions of the orbit. I. Review; hemangioma, lymphangioma and embryonal rhabdomyosarcoma].

    PubMed

    Gloor, B; Kalman, A

    1992-11-01

    From 1987 to 1990 182 patients were treated for orbital lesions in the Department of Ophthalmology of the University of Zürich. 37% were tumors (without tumors of the vascular system), 20% inflammatory lesions, 12% lesions of the vascular system and tumors of it, the rest was not diagnosed. On this background the first of two chapters on orbital tumors deals with diagnosis, differential diagnosis, therapy and follow up of the capillary hemangioma, cavernous hemangioma, lymphangioma and embryonal rhabdomyosarcoma. Although ultrasound echography, CT, MRI and angiography have greatly changed the diagnostic work up of orbital lesions, diagnosis is by far not made straight forward but often only after errors. To enhance diagnosis in the future this study is meant to analyse our misinterpretations. In the case of capillary hemangioma only complications justify an active treatment, normally the lesion resolves spontaneously. The infiltration of the upper eyelid with ptosis needs to be treated because of the risk of amblyopia. Our cases demonstrate, that the attempt of treatment with steroids is justified. Embolisation in the region of the a. ophthalmica is quite dangerous. The cavernous hemangioma only needs treatment in the case of compression of the optical nerve and total excision is not mandatory. The lymphangioma, although classified as benign tumor, can only be excised subtotally and with the danger of traumatising important structures of the orbit. The infiltrative growth and tendency of recurrence in fact is dangerous. It is important to diagnose the tumor without biopsy and to wait with surgical treatment as long as possible. The embryonal rhabdomyosarcoma itself is rare but it is the most frequent primary malignant tumor in childhood. Even accounting for being familiar with mimikri-false history of trauma, inflammation, hemangioma-like angiography-the diagnosis is often made rather late. Our cases demonstrate this and also the change of treatment in the last 30 years. Unfortunately the prognosis of the good results of chemotherapy in combination with radiation if necessary is clouded by the occurrence of secondary malignant tumors. PMID:1479785

  12. Ptotic gall bladder with hepatic masses: a case report.

    PubMed

    Aydin, Hasan; Aydin, Z Banu; Hekimo?lu, Baki; Görmeli, Ay?e

    2013-01-01

    Gall bladder (GB) may be found in a variety of abnormal positions. Most of them are due to arrested development of embryonic growth at different stages. A 63-year-old female patient was admitted to our radiology unit for magnetic resonance imaging (MRI) of the liver for the lesions identified in abdominal ultrasonography (US) and computed tomography (CT). MRI showed that there was a lobulated heterogenous mass in the left lobe of the liver and a smaller one in the right lobe of the liver with the same appearance. The inferior pole of the liver was located in the pelvic space, and the GB, which contained sludges and stones, was lying down to the upper pelvic space. Hepatic masses were considered to be hemangiomas, and GB was diagnosed as ptotic GB with luminal sludge and stones. In this case, especially, MR imaging helped the surgeon to plan a proper approach to the GB in abnormal localization. PMID:23476872

  13. Hepatic angiomyolipomas: ultrasonic characteristics of 25 patients from a single center.

    PubMed

    Wang, Baohua; Ye, Zhengdu; Chen, Yan; Zhao, Qiyu; Huang, Min; Chen, Fen; Li, Yanyuan; Jiang, Tian'an

    2015-02-01

    Twenty-five pathologically proven hepatic angiomyolipomas (AMLs) were included in the study. Ultrasonic features of hepatic AMLs were reviewed. Three types of echogenicity were observed on ultrasound examination: (i) strong hyper-echogenicity, (ii) moderate hyper-echogenicity and (iii) hypo-echogenicity. Vascular signals within tumors could be detected in 22 (88.00%) tumors as multiple punctiform, filiform or dendriform signals by color Doppler flow imaging. Based on the enhancement patterns in the arterial, portal and late phases, the features of hepatic AMLs on contrast-enhanced ultrasound were divided into four subtypes: (i) "fast in slow out" (68.00%, n = 17); (ii) "fast in same out" (16%, n = 4); (iii) "fast in fast out" (12.00%, n = 3); and (iv) "fast in uneven out" (4.00%, n = 1). Contrast-enhanced ultrasound diagnosed 22 (88.00%) tumors as benign tumors and 13 (52.00%) as hepatic AMLs. Four cases were misdiagnosed as hepatic hemangioma, five cases as focal nodular hyperplasia (total = 36.00%). The rate of correct diagnosis of hepatic AMLs increased significantly from 24.00% for ultrasound alone to 52.00% for contrast-enhanced ultrasound. Therefore, information obtained from ultrasound, color Doppler flow imaging and contrast-enhanced ultrasound should be combined to improve diagnosis. PMID:25542497

  14. Hepatic angiomyolipoma.

    PubMed

    Pounder, D J

    1982-10-01

    An angiomyolipoma of the liver was an incidental autopsy finding in a 65-year-old man. This is the third recorded primary hepatic angiomyolipoma. There were no stigmata of tuberose sclerosis but tuberose sclerosis has been reported previously in association with fatty tumors of the liver, suggesting that such lesions, like their renal counterparts, may be choristomas. PMID:7180967

  15. Autoimmune Hepatitis

    MedlinePLUS

    ... hepatitis is the most common form in North America. Type 1 can occur at any age; however, ... transplant in a hospital. When possible, the patient fasts for 8 hours before the ... medications, contact the U.S. Food and Drug Administration toll-free at 1–888– ...

  16. Hepatitis C

    MedlinePLUS

    ... items such as razors and toothbrushes. Practice safer sex . If you or your partner is infected with hepatitis C and you have been in a stable and monogamous (no other partners) relationship, the risk of giving the virus to, or getting ...

  17. Hepatitis B

    MedlinePLUS

    ... liver failure, or liver cancer. There is a vaccine for HBV. It requires three shots. All babies should get ... it too. If you travel to countries where Hepatitis B is common, you should get the vaccine. NIH: National Institute of Diabetes and Digestive and ...

  18. Hepatitis B

    MedlinePLUS

    ... B to come back? Should I get the hepatitis B vaccine? What are the side effects of antiviral medicines? Will my liver ever be normal again? Written by familydoctor.org editorial staff Reviewed/Updated: 03/14 Created: 10/96

  19. Central giant cell lesion.

    PubMed

    Valentine, James C; Nelson, Brenda L

    2011-12-01

    A classic case of central giant cell lesion (CGCL) is presented with emphasis on clinical, radiologic, and histologic features. The differential is discussed including peripheral giant cell granuloma, brown tumor of hyperparathyroidism, and giant cell tumor of bone. The molecular pathway of osteoclastogenesis is selectively reviewed and applied to suggest possible etiologies of the giant cell lesions. CGCL syndromes and treatment are also discussed. PMID:21898170

  20. Hepatitis and Asian Americans

    MedlinePLUS

    ... from hepatitis C than non-Hispanic whites. VIRAL HEPATITIS Death Rates for Viral Hepatitis, 2013 (all types) ... data/nvsr/nvsr64/nvsr64_02.pdf [PDF | 2MB] HEPATITIS A Hepatitis A, Acute (Cases per 100,000 ...

  1. Giant impacts on giant planets

    NASA Astrophysics Data System (ADS)

    de Pater, Imke

    2014-10-01

    The 2009 impact and recent superbolides on Jupiter caught the world by surprise and cast doubt on impactor flux estimates for the outer solar system. Enhanced amateur planetary imaging techniques yield both high spatial resolution (enabling the 2009 impact debris field detection) and rapid frame rates (enabling the 2010/2012 impact flash detections and lightcurve measurements).We propose a ToO program to image future impacts on Jupiter and Saturn. To remove the possibility of impact cloud non-detections, the program will be triggered only if an existing impact debris field is seen, an object on a collision course with Jupiter or Saturn is discovered, or an impact light curve is measured with an estimated total energy large enough to generate an impact cloud in a giant planet atmosphere (10^20 J).HST provides the only way to image these events in the ultraviolet, providing information on aerosol altitudes and on smaller particles that are less visible to ground-based infrared observations. High-resolution imaging with proper timing (not achievable from the ground) is required to measure precisely both the velocity fields of impact sites and the optical spectrum of impact debris. HST observations of past impacts on Jupiter have also served both as cornerstones of science investigations at other wavelengths and as vehicles for effective public outreach.Large outer solar system impacts are governed by the same physics as in the terrestrial events that dominate the impact threat to humans. Studying the behavior of impactors of various sizes and compositions, as they enter the atmosphere at varying angles and speeds, will better quantify terrestrial impact hazards.

  2. Giant impacts on giant planets

    NASA Astrophysics Data System (ADS)

    de Pater, Imke

    2012-10-01

    The 2009 impact on Jupiter caught the world by surprise and cast doubt on impactor flux estimates for the outer solar system. Enhanced amateur planetary imaging techniques yield both high spatial resolution {enabling the 2009 impact debris field detection} and rapid frame rates {enabling the 2010 impact flash detections and lightcurve measurements}.We propose a Target of Opportunity program to image future impacts on Jupiter and Saturn. To remove the possibility of impact cloud non-detections, the program will be triggered only if an existing impact debris field is seen, an object on a collision course with Jupiter or Saturn is discovered, or an impact light curve is measured with an estimated total energy large enough to generate an impact cloud in a giant planet atmosphere.HST provides the only way to image these events in the ultraviolet, providing information on aerosol altitudes and on smaller particles that are less visible to ground-based infrared observations. High-resolution imaging with proper timing {not achievable from the ground} is required to measure precisely both the velocity fields of impact sites and the optical spectrum of impact debris. HST observations of past impacts on Jupiter have also served both as cornerstones of science investigations at other wavelengths and as vehicles for effective public outreach.Large outer solar system impacts are governed by the same physics as in the terrestrial events that dominate the impact threat to humans. Studying the behavior of impactors of various sizes and compositions, as they enter the atmosphere at varying angles and speeds, will better quantify terrestrial impact hazards.

  3. Giant impacts on giant planets

    NASA Astrophysics Data System (ADS)

    de Pater, Imke

    2013-10-01

    The 2009 impact and recent superbolides on Jupiter caught the world by surprise and cast doubt on impactor flux estimates for the outer solar system. Enhanced amateur planetary imaging techniques yield both high spatial resolution {enabling the 2009 impact debris field detection} and rapid frame rates {enabling the 2010/2012 impact flash detections and lightcurve measurements}.We propose a ToO program to image future impacts on Jupiter and Saturn. To remove the possibility of impact cloud non-detections, the program will be triggered only if an existing impact debris field is seen, an object on a collision course with Jupiter or Saturn is discovered, or an impact light curve is measured with an estimated total energy large enough to generate an impact cloud in a giant planet atmosphere {10^20 J}.HST provides the only way to image these events in the ultraviolet, providing information on aerosol altitudes and on smaller particles that are less visible to ground-based infrared observations. High-resolution imaging with proper timing {not achievable from the ground} is required to measure precisely both the velocity fields of impact sites and the optical spectrum of impact debris. HST observations of past impacts on Jupiter have also served both as cornerstones of science investigations at other wavelengths and as vehicles for effective public outreach.Large outer solar system impacts are governed by the same physics as in the terrestrial events that dominate the impact threat to humans. Studying the behavior of impactors of various sizes and compositions, as they enter the atmosphere at varying angles and speeds, will better quantify terrestrial impact hazards.

  4. Successful Propranolol Treatment of a Large Size Infantile Hemangioma of the Face Causing Recurrent Bleeding and Visual Field Disruption

    PubMed Central

    Saaiq, Muhammad; Ashraf, Bushra; Siddiqui, Saad; Ahmad, Shehzad; Salman Zaib, Muhammad

    2015-01-01

    A 29 days old Pakistani female infant was presented to our outpatient department with two weeks history of a rapidly progressing large size facial hemangioma involving most of the right cheek and right eyelids. The infant was unable to open the right eye. There was also a small hemangioma on the right second toe. Additionally, three similar lesions were found on the right side of the palate and adjoining buccogingival surfaces. The parents were particularly concerned about the explosive progression of the lesions, recurrent bleeding episodes from ulcerated areas of the cheek lesion and complete occlusion of the right eye. Following four weeks therapy with propranolol in a dose of 2 mg/kg/day, the hemangiomas rapidly regressed, the bleeding episodes ceased and the infant started opening the eye. PMID:25606481

  5. Early homogeneously enhancing hemangioma versus hepatocellular carcinoma: differentiation using quantitative analysis of multiphasic dynamic magnetic resonance imaging.

    PubMed

    Jeong, M G; Yu, J S; Kim, K W; Jo, B J; Kim, J K

    1999-06-01

    The aim of this study was to determine the usefulness of quantitative analysis of multiphasic dynamic contrast-enhanced magnetic resonance (MR) imaging in differentiating early homogeneously enhancing hemangiomas from hepatocellular carcinomas (HCCs). Four-phased dynamic MR imaging at 10 sec (first phase of dynamic contrast-enhanced imaging, P1), 35 sec (second phase, P2), 60 sec (third phase, P3) and 300 sec (delay phase, P4) immediately after intravenous administration of 0.1 mmol/kg Gadolinium-DTPA was obtained with 1.5-T unit with breath-hold multisection FLASH (fast low angle-shot) sequence (TR/TE, 113-130 msec/4.1 msec; flip angle, 80 degrees). Thirty-three HCCs and 18 hemangiomas, homogeneously enhanced on P1, were included in the study. The images were evaluated quantitatively (SNR, signal-to-noise ratio; and CNR, contrast- to- noise ratio of lesions). Quantitatively, mean CNR was higher for hemangiomas than for HCCs on all phases, and the difference in CNRs between hemangioma and HCCs was statistically significant on P3 and P4 (p < 0.0001). When the cutoff for CNR was set at a value of 7.00 on P3 and 1.00 on P4, sensitivity, specificity and accuracy were 94.4%, 93.9%, and 94.1% on P3, and 94.4%, 81.8%, and 86.3% on P4, respectively. There was no statistically significant difference in SNRs between HCC and hemangioma. The differential diagnosis between early, homogeneously enhancing hemangiomas and HCCs was more confidently made with CNRs of lesions on P3 and P4 in dynamic contrast-enhanced MR imaging. PMID:10412337

  6. Delta agent (Hepatitis D)

    MedlinePLUS

    ... is found only in people who carry the hepatitis B virus. HDV may make liver disease worse in people ... can even cause symptoms in people who carry hepatitis B virus but who never had symptoms. Hepatitis D infects ...

  7. Alcoholic hepatitis

    Microsoft Academic Search

    Kester I. Crosse; Frank A. Anania

    2002-01-01

    Opinion statement  Alcoholic hepatitis is a common clinical problem confronting gastroenterologists and hepatologists alike. The fundamental\\u000a issue regarding treatment of this disease is its recognition on the part of the physician. Chronic alcohol abuse, fever, leukocytosis,\\u000a jaundice, and encephalopathy are key symptoms and signs that should prompt consideration of this diagnosis. Nutrition and\\u000a abstinence from alcohol are the cornerstones of therapy.

  8. Hepatitis E.

    PubMed

    Aggarwal, Rakesh; Jameel, Shahid

    2011-12-01

    Hepatitis E refers to liver disease caused by the hepatitis E virus (HEV), a small, nonenveloped virus with a single-stranded RNA genome. The virus has four genotypes, but only one serotype. Genotypes 1 and 2 exclusively infect humans, whereas genotypes 3 and 4 also infect pigs and several other mammalian species. Though HEV does not grow well in cell culture, several aspects of its biology and pathogenesis have been worked out using animal models and cell transfection studies, and by analogy with other related viruses. HEV itself appears noncytopathic, and the liver injury during hepatitis E may be mediated by the host immune response. In areas with poor sanitation, HEV infection is common and presents as outbreaks and also as sporadic cases with acute self-limited hepatitis. The transmission is feco-oral, usually through contaminated drinking water. The disease often affects young adults and is particularly severe among pregnant women and persons with preexisting liver cirrhosis. In the developed world, the disease is being increasingly recognized. It occurs as occasional sporadic cases, most often among elderly men with coexisting illnesses. These appear to be related to zoonotic transmission. Chronic infection is known among immunosuppressed persons in these regions and may progress to liver cirrhosis. Serological tests for diagnosis of HEV exposure and recent infection, namely immunoglobulin (Ig)G and IgM anti-HEV, respectively, need further improvement in sensitivity and specificity, particularly when used in developed countries. Two recombinant protein vaccines have undergone successful human trials, but are not yet commercially available. Recent development of cell-culture methods for HEV should allow a better understanding of this enigmatic agent. PMID:21932388

  9. Autoimmune hepatitis.

    PubMed

    Sahebjam, Farhad; Vierling, John M

    2015-06-01

    Autoimmune hepatitis is a chronic liver disease putatively caused by loss of tolerance to hepatocytespecific autoantigens. It is characterized by female predilection, elevated aminotransferase levels, autoantibodies, increased ?-globulin or IgG levels and biopsy evidence of interface hepatitis. It is currently divided into types 1 and 2, based on expression of autoantibodies. Autoantigenic epitopes have been identified only for the less frequent type 2. Although autoimmune hepatitis occurs in childhood, this review focuses on disease in adults. In the absence of pathognomonic biomarkers, diagnosis requires consideration of clinical, biochemical, serological and histological features, which have been codified into validated diagnostic scoring systems. Since many features also occur in other chronic liver diseases, these scoring systems aid evaluation of the differential diagnosis. New practice guidelines have redefined criteria for remission to include complete biochemical and histological normalization on immunosuppressive therapy. Immunosuppression is most often successful using prednisone or prednisolone and azathioprine; however, the combination of budesonide and azathioprine for non-cirrhotic patients offers distinct advantages. Patients failing standard immunosuppression are candidates for alternative immunosuppressive regimens, yet none of the options has been studied in a randomized, controlled trial. Overlap syndromes with either primary sclerosing cholangitis or primary biliary cirrhosis occur in a minority. Liver transplantation represents a life-saving option for patients presenting with acute liver failure, severely decompensated cirrhosis or hepatocellular carcinoma. Transplant recipients are at risk for recurrent autoimmune hepatitis in the allograft, and de novo disease may occur in patients transplanted for other indications. Patients transplanted for AIH are also at risk for recurrent or de novo inflammatory bowel disease. Progress in our understanding of the immunopathogenesis should lead to identification of specific diagnostic and prognostic biomarkers and new therapeutic strategies. PMID:25749982

  10. Initiation and use of propranolol for infantile hemangioma: report of a consensus conference.

    PubMed

    Drolet, Beth A; Frommelt, Peter C; Chamlin, Sarah L; Haggstrom, Anita; Bauman, Nancy M; Chiu, Yvonne E; Chun, Robert H; Garzon, Maria C; Holland, Kristen E; Liberman, Leonardo; MacLellan-Tobert, Susan; Mancini, Anthony J; Metry, Denise; Puttgen, Katherine B; Seefeldt, Marcia; Sidbury, Robert; Ward, Kendra M; Blei, Francine; Baselga, Eulalia; Cassidy, Laura; Darrow, David H; Joachim, Shawna; Kwon, Eun-Kyung M; Martin, Kari; Perkins, Jonathan; Siegel, Dawn H; Boucek, Robert J; Frieden, Ilona J

    2013-01-01

    Infantile hemangiomas (IHs) are common neoplasms composed of proliferating endothelial-like cells. Despite the relative frequency of IH and the potential severity of complications, there are currently no uniform guidelines for treatment. Although propranolol has rapidly been adopted, there is significant uncertainty and divergence of opinion regarding safety monitoring, dose escalation, and its use in PHACE syndrome (PHACE = posterior fossa, hemangioma, arterial lesions, cardiac abnormalities, eye abnormalities; a cutaneous neurovascular syndrome characterized by large, segmental hemangiomas of the head and neck along with congenital anomalies of the brain, heart, eyes and/or chest wall). A consensus conference was held on December 9, 2011. The multidisciplinary team reviewed existing data on the pharmacologic properties of propranolol and all published reports pertaining to the use of propranolol in pediatric patients. Workgroups were assigned specific topics to propose protocols on the following subjects: contraindications, special populations, pretreatment evaluation, dose escalation, and monitoring. Consensus protocols were recorded during the meeting and refined after the meeting. When appropriate, protocol clarifications and revision were made and agreed upon by the group via teleconference. Because of the absence of high-quality clinical research data, evidence-based recommendations are not possible at present. However, the team agreed on a number of recommendations that arose from a review of existing evidence, including when to treat complicated IH; contraindications and pretreatment evaluation protocols; propranolol use in PHACE syndrome; formulation, target dose, and frequency of propranolol; initiation of propranolol in infants; cardiovascular monitoring; ongoing monitoring; and prevention of hypoglycemia. Where there was considerable controversy, the more conservative approach was selected. We acknowledge that the recommendations are conservative in nature and anticipate that they will be revised as more data are made available. PMID:23266923

  11. Cardiac Hemangioma of RVOT in a Patient with Atypical Chest Pain

    PubMed Central

    Vakili, Hossein; Khaheshi, Isa; Foroughi, Mahnoosh; Ghaderi, Hamid; Esmaeeli, Shooka; Jafari, Mostafa

    2014-01-01

    A 40-year-old man presented with atypical chest pain and fatigue from 15 days ago a suspicious mass in the right ventricle based on a bed side transthoracic echocardiography. Preoperative diagnosis of a cardiac hemangioma comes to mind in a minority of cases. In our case, a cardiac tumor was diagnosed and the vascular nature of the tumor was suggested by vascular blush on the coronary angiography. In addition, right ventriculotomy was the approach of choice in our case because of its inaccessibility and its particular location. PMID:25110477

  12. Unilateral livedoid vasculopathy associated with involutional phase of cutaneous infantile hemangioma: the connection to coagulation disorders.

    PubMed

    Criado, Paulo Ricardo; Alavi, Afsaneh; Halpern, Ilana; Sotto, Mirian Nacagami; Kirsner, Robert S

    2013-12-01

    Livedoid vasculopathy is a bilateral painful and recurrent cutaneous ulcerative disorder of the legs that leads to atrophie blanche, atrophic white-porcelain scars, and is associated with disorders of fibrinolysis and/or coagulation. We present a young boy with an association between livedoid vasculopathy in the area of a previous involuted cutaneous hemangioma. We found 4 uncommon abnormalities associated with thrombo-occlusive events: heterozygous 20210 A?G genotype of prothrombin, reduced activity of anticoagulation proteins C and S, and elevated lipoprotein (a). PMID:24043683

  13. Vascular endothelial growth factor confers a growth advantage in vitro and in vivo to stromal cells cultured from neonatal hemangiomas.

    PubMed Central

    Berard, M.; Sordello, S.; Ortega, N.; Carrier, J. L.; Peyri, N.; Wassef, M.; Bertrand, N.; Enjolras, O.; Drouet, L.; Plouet, J.

    1997-01-01

    Neonatal hemangioma is a common benign proliferation of unorganized structures containing stromal and capillary endothelial cells. We tested the hypothesis that such cell proliferation might result from the release by stromal cells of endothelial cell mitogens. Stromal cells cultured from biopsies of surgically removed life-threatening hemangiomas released an endothelial cell mitogen in vitro that was indistinguishable from vascular endothelial growth factor (VEGF) based on independent criteria such as affinity chromatography for heparin or anti-VEGF IgG and radioreceptor assay. A functional product of the KDR gene encoding a cognate VEGF receptor was also expressed by these stromal cells. Transient transfection with antisense oligonucleotides targeted on the translation initiation codon of KDR abolished its tyrosine phosphorylation and mitogenic response of neonatal hemangioma cells to VEGF, confirming the existence of an autocrine loop of proliferation. When grafted in nude mice, these stromal cells elicited an angiogenic response that was blocked by neutralizing anti-VEGF IgG. These results might provide a clue to the importance of stromal cells in the pathogeny of neonatal hemangiomas. Images Figure 1 Figure 2 Figure 4 Figure 6 PMID:9094988

  14. Vascular endothelial growth factor expression and pathological changes in the local tissue of facial hemangiomas following injections with pure alcohol

    PubMed Central

    FU, ZHAO-JUN; LI, CHUN-MING; WANG, TAI-HE; JIANG, ZHU-LING; FU, ZHAO-CHEN

    2015-01-01

    The aim of the present study was to investigate the association between the formation of hemangioma and the expression of vascular endothelial growth factor (VEGF) following local injections of pure alcohol in patients exhibiting hemangioma. Ten healthy subjects (control group) and 10 hemangioma patients (treatment group) were included in the study population, with the hemangioma patients receiving one injection of pure alcohol. The VEGF levels were evaluated in the treatment and control group subjects prior to and following the injection using enzyme-linked immunosorbent assay; furthermore, local tissue was excised to perform pathological analysis one week after the injections. The VEGF levels of the healthy group were identified to be significantly lower when compared with those of the treatment group prior to the injections (P<0.01) and one week after the injections (P<0.01), however, were not significantly different when compared with the treatment group one month after the injections (P>0.01). Therefore, serum VEGF concentrations in the peripheral blood may be a clinical indicator of the efficacy of clinical treatment and aid with determination of the prognosis. PMID:25663863

  15. Fusion events lead to truncation of FOS in epithelioid hemangioma of bone.

    PubMed

    van IJzendoorn, David G P; de Jong, Danielle; Romagosa, Cleofe; Picci, Piero; Benassi, Maria Serena; Gambarotti, Marco; Daugaard, Soeren; van de Sande, Michiel; Szuhai, Karoly; Bovée, Judith V M G

    2015-09-01

    Epithelioid hemangioma of bone is a locally aggressive vascular neoplasm. It can be challenging to diagnose because of the wide histological spectrum, which can make it difficult to differentiate from other vascular neoplasms such as epithelioid hemangioendothelioma or epithelioid angiosarcoma. COBRA-FISH karyotyping identified a balanced t(3;14) translocation. Transcriptome sequencing of the index case and two other epithelioid hemangiomas revealed a recurrent translocation breakpoint involving the FOS gene, which was fused to different partners in all three cases. The break was observed in exon 4 of the FOS gene and the fusion event led to the introduction of a stop codon. In all instances, the truncation of the FOS gene would result in the loss of the transactivation domain (TAD). Using FISH probes we found a break in the FOS gene in two additional cases, in none of these cases a recurrent fusion partner could be identified. In total, FOS was split in 5/7 evaluable samples. We did not observe point mutations leading to early stop codons in any of the 10 cases where RNA was available. Detection of FOS rearrangement may be a useful diagnostic tool to assist in the often difficult differential diagnosis of vascular tumors of bone. Our data suggest that the translocation causes truncation of the FOS protein, with loss of the TAD, which is thereby a novel mechanism involved in tumorigenesis. © 2015 Wiley Periodicals, Inc. PMID:26173738

  16. Proapoptotic effect and the mechanism of action of pingyangmycin on cavernous hemangiomas

    PubMed Central

    HUANG, YIDENG; LI, PING; XIA, SIWEN; ZHUO, YANG; WU, LONGJUN

    2014-01-01

    This study aimed to investigate the proapoptotic effects and the mechanism of action of pingyangmycin (PY) on cavernous hemangioma. The rat spleen was used as a model of cavernous hemangioma. PY was injected into the spleen and the pathological changes were observed at different time-points. Apoptosis was detected using terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay and transmission electron microscopy (TEM). The expression levels of the apoptosis-related protein, caspase-3, were determined using immunohistochemistry and image analysis. Rats injected with normal saline were the control group. Injection of normal saline did not damage rat spleens. On days 2 and 5 following PY injection, the spleens exhibited slight swelling. On days 8 and 14, atrophic changes were observed and the splenic sinus endothelial cells were damaged. At various time-points following PY injection, the apoptotic cells were observed by TEM. The TUNEL assay showed that apoptosis occurred widely among the splenic sinus endothelial cells and other splenic cells. The apoptotic rate and caspase-3 expression levels increased with prolonged PY exposure. PY induced apoptosis of splenic sinus endothelial cells through the caspase-3 activation pathway, and resulted in endothelial cell necrosis and fibroblast hyperplasia. PMID:24396428

  17. Role of MRI in the diagnosis and evaluation of cavernous hemangioma of the arm

    PubMed Central

    Ciurea, ME; Bondari, S; Stoica, LE; Gheonea, IA

    2014-01-01

    Abstract Sinusoidal hemangioma is a rare type of cavernous hemangioma with different clinico-pathological aspects. They are usually localized in the extremities with interest in the subcutaneous layer. The new imaging techniques play an important role in diagnosis, evaluation and follow-up of these types of tumors. We describe the case of a 21-year-old patient, four times operated for a recurrent soft tissue tumor, located intramuscularly in the distal third of the upper limb. Plain X-ray and computer tomography (CT) showed a nonspecific mass with calcification. The MRI (magnetic resonance imaging) exam demonstrated a lobulated heterogeneous signal tumor mass in the biceps brachial muscles, with high signal intensity on T2 weighted images and intermediate signal on T1 weighted images. MRI accurately assessed the extent of the tumor and evaluated the recurrence. MRI imagings combined with contrast-enhanced sequences were used to classify the lesions in low flow vascular disorders. CT angiography with multiplanar reconstructions (MPR), maximum intensity projections (MIP) and volume-rendered reconstructions (VR) was useful in confirming the venous origin of the tumor. PMID:24653757

  18. Role of MRI in the diagnosis and evaluation of cavernous hemangioma of the arm.

    PubMed

    Ciurea, M E; Bondari, S; Stoica, L E; Gheonea, I A

    2014-03-15

    Sinusoidal hemangioma is a rare type of cavernous hemangioma with different clinico-pathological aspects. They are usually localized in the extremities with interest in the subcutaneous layer. The new imaging techniques play an important role in diagnosis, evaluation and follow-up of these types of tumors. We describe the case of a 21-year-old patient, four times operated for a recurrent soft tissue tumor, located intramuscularly in the distal third of the upper limb. Plain X-ray and computer tomography (CT) showed a nonspecific mass with calcification. The MRI (magnetic resonance imaging) exam demonstrated a lobulated heterogeneous signal tumor mass in the biceps brachial muscles, with high signal intensity on T2 weighted images and intermediate signal on T1 weighted images. MRI accurately assessed the extent of the tumor and evaluated the recurrence. MRI imagings combined with contrast-enhanced sequences were used to classify the lesions in low flow vascular disorders. CT angiography with multiplanar reconstructions (MPR), maximum intensity projections (MIP) and volume-rendered reconstructions (VR) was useful in confirming the venous origin of the tumor. PMID:24653757

  19. [Cloning and expression of gp85 gene of subgroup J avian leukosis virus isolated from hemangiomas].

    PubMed

    Qiu, Bo; Liu, Gong-zhen; Wang, Xiao-wei; Wang, Feng; Chen, Hong-boi; Cheng, Zi-qiang

    2011-03-01

    During July to November in 2007, several outbreaks of Hemangiomas in Hy-line Brown laying hens were observed in China. The virus that infected these flocks was identified in cultured DF-1 cells by PCR and indirect fluorescent assay (IFA) with ALV-J specific monoclonal antibody JE-9. The gp85 gene of one strain named WS0705 of ALV-J was cloned and expressed. Phylogenetic analysis showed that gp85 amino sequences of WS0705 strain had the highest homology with that of the prototype HPRS-103. The gp85 gene from a constructed plasmid pMD18-T-WS0705gp85 was cloned into baculovirus transfer vector. rBac-WS0705gp85 was obtained by the Bac-to-Bac baculovirus expression system. The rBac-WS0705gp85 protein was analyzed by indirect immunofluor escence assay and Western blot. The results showed that positive green fluorescent was present in Sf9 cells infected with the recombinant virus and a 35 kD band was present in western blot. It is concluded that WS0705 gp85 gene was expressed in Sf9 cells infected with the recombinant virus and the SU protein of WS0705 can bind specifically to JE9 MAb of ALV-J. The expressed protein can be used to detect hemangiomas induced by ALV-J. PMID:21528540

  20. Hepatic osteodystrophy.

    PubMed

    Gatta, Angelo; Verardo, Alberto; Di Pascoli, Marco; Giannini, Sandro; Bolognesi, Massimo

    2014-09-01

    Metabolic disturbances of bone are frequent in patients with chronic liver disease. The prevalence of osteoporosis among patients with advanced chronic liver disease is reported between 12% and 55%; it is higher in primary biliary cirrhosis. All patients with advanced liver disease should be screened for osteoporosis with a densitometry, especially if the etiology is cholestatic and in the presence of other risk factors. Clinical relevance of hepatic osteodystrophy increases after liver transplantation. After liver transplant, a rapid loss of bone mineral density can be detected in the first 6 months, followed by stabilization and slight improvement of the values. At the time of transplantation, bone density values are very important prognostic factors. Therapy of hepatic osteodystrophy is based primarily on the control of risk factors: cessation of tobacco and alcohol assumption, reduction of caffeine ingestion, exercise, supplementation of calcium and vitamin D, limitation of drugs such as loop diuretics, corticosteroids, cholestyramine. Bisphosphonates have been proposed for the therapy of osteoporosis in patients with liver disease, particularly after liver transplantation. The possible side effects of oral administration of bisphosphonates, such as the occurrence of esophageal ulcerations, are of particular concern in patients with liver cirrhosis and portal hypertension, due to the risk of gastrointestinal hemorrhage from ruptured esophageal varices, although this risk is probably overestimated. PMID:25568651

  1. Giant Sequoia Pinecone

    USGS Multimedia Gallery

    A pinecone of a giant sequoia rests on the forest floor. A large sequoia tree can have several thousand pinecones at a time. Although giant sequoia trees are among the largest trees in the world, their pinecones are comparatively small, usually only 2 inches or so....

  2. Giant Sequoia Pinecone

    USGS Multimedia Gallery

    A single giant sequoia pinecone rests in the bark of its parent. A large sequoia tree can have several thousand pinecones at a time. Although giant sequoia trees are among the largest trees in the world, their pinecones are comparatively small, usually only 2 inches or so....

  3. A Rare Case of Left Ventricular Intramural Hemangioma Diagnosed Using 1.5-T Cardiac MRI with Histopathological Correlation and Successfully Treated by Surgery

    SciTech Connect

    Marrone, Gianluca, E-mail: gmarrone@ismett.ed [Mediterranean Institute of Transplantation and High Specialization Therapy (ISMETT), Diagnostic and Interventional Radiology (Italy); Sciacca, Sergio, E-mail: ssciacca@ismett.edu; D'Ancona, Giuseppe, E-mail: gdancona@ismett.edu; Pilato, Michele, E-mail: mpilato@ismett.ed [Mediterranean Institute of Transplantation and High Specialization Therapy (ISMETT), Division of Cardiac Surgery (Italy); Luca, Angelo, E-mail: aluca@ismett.ed [Mediterranean Institute of Transplantation and High Specialization Therapy (ISMETT), Diagnostic and Interventional Radiology (Italy); Gridelli, Bruno, E-mail: bgridelli@ismett.ed [Mediterranean Institute of Transplantation and High Specialization Therapy (ISMETT), Division of Surgery (Italy)

    2010-02-15

    Hemangiomas are vascular tumors composed of blood vessels, frequently localized in the skin and subcutaneous muscles; their localization in the heart is exceptional. The most common localizations are the lateral walls of the left ventricle, the anterior wall, and the septum. Mostly, these tumors grow intracavitarily, rarely intramurally. We describe a singular case of left ventricular intramural hemangioma, detected and diagnosed using newer magnetic resonance imaging (MRI) modalities, confirmed by histopathological results, and treated successfully by surgery.

  4. Hepatitis B: Information for Parents

    MedlinePLUS

    ... protect against hepatitis B is by getting the hepatitis B vaccine. Doctors recommend that all children get the vaccine. ... child) Is the hepatitis B shot safe? The hepatitis B vaccine is very safe, and it is effective at ...

  5. Hepatitis Information for the Public

    MedlinePLUS

    ... of Viral Hepatitis Contact Us Quick Links to Hepatitis ... A | B | C | D | E Viral Hepatitis Home ... Outbreaks State and Local Partners & Grantees Resource Center Hepatitis Information for the Public Recommend on Facebook Tweet ...

  6. Baseline thrombocytopenia complicated by recurrent episodes of transient severe thrombocytopenia following infections in an adult woman with a non involuting congenital hemangioma – a case report

    PubMed Central

    2013-01-01

    Background Congenital hemangiomas are benign abnormal proliferation of blood vessels. Noninvoluting congenital hemangiomas are a rare variant which persist, and may become bigger. Hemangiomas are known to be associated with thrombocytopenia, microangiopathic hemolytic anemia and Kasabach-Merritt phenomenon. Kasabach-Merritt phenomenon is characterized by consumptive coagulopathy with microangiopathic haemolyic anemia and thrombocytopenia. Platelet sequestration in the hemangioma or increased destruction which may either be immune or non immune are also further contributors to thrombocytopenia. Case presentation A 45 year old female with a non involuting hemangioma and baseline thrombocytopenia was observed to develop repeated episodes of transient severe thrombocytopenia associated with a variety of infectious conditions. Laboratory investigations suggested a peripheral mechanism. Platelet counts always returned to baseline levels on resolution of the precipitating infection. Conclusion The authors report this phenomenon as the first reported case of baseline thrombocytopenia complicated by recurrent episodes of transient severe thrombocytopenia following infections associated with a non involuting congenital hemangioma. The observations made in this patient were unique and hitherto unreported in medical literature. Both peripheral sequestration and destructive consumption were considered likely. Consumptive mechanisms were likely to encompass either or both immune and non immune causes. Further studies are needed to establish the precise pathogenesis. PMID:23758712

  7. Thermal Giant Gravitons

    NASA Astrophysics Data System (ADS)

    Armas, Jay; Harmark, Troels; Obers, Niels A.; Orselli, Marta; Pedersen, Andreas Vigand

    2012-11-01

    We study the giant graviton solution as the AdS5 × S 5 background is heated up to finite temperature. The analysis employs the thermal brane probe technique based on the blackfold approach. We focus mainly on the thermal giant graviton corresponding to a thermal D3-brane probe wrapped on an S 3 moving on the S 5 of the background at finite temperature. We find several interesting new effects, including that the thermal giant graviton has a minimal possible value for the angular momentum and correspondingly also a minimal possible radius of the S 3. We compute the free energy of the thermal giant graviton in the low temperature regime, which potentially could be compared to that of a thermal state on the gauge theory side. Moreover, we analyze the space of solutions and stability of the thermal giant graviton and find that, in parallel with the extremal case, there are two available solutions for a given temperature and angular momentum, one stable and one unstable. In order to write down the equations of motion, action and conserved charges for the thermal giant graviton we present a slight generalization of the blackfold formalism for charged black branes. Finally, we also briefly consider the thermal giant graviton moving in the AdS5 part.

  8. Estimates of absorbed dose in different organs in children treated with radium for skin hemangiomas

    SciTech Connect

    Lundell, M. [Karolinska Hospital, Stockholm (Sweden)

    1994-12-01

    Between 1930 and 1959, more than 10,000 infants were treated at Radiumhemmet, Stockholm, with radium ({sup 226}Ra) needles and/or tubes for hemangioma of the skin. Absorbed dose to the brain, eye lenses, parotid glands, thyroid gland, breast enlarge, lungs, stomach, intestine, ovaries, testicles and bone marrow were calculated for each individual. The mean absorbed dose to the different organs ranged from 0.06 to 0.48 Gy. The highest absorbed dose was given to the breast (maximum 47.7 Gy). There was a wide dose range for each organ which was due mainly to differences in the distance between the applicator and the organ. The absorbed dose to all organs decreased on average by 32% during the study period. This was due to a 25% decrease in the treatment time and a change in the distribution of the treatment sites. 17 refs., 4 figs., 4 tabs.

  9. Preliminary study on plasma RPN concentration of patients with infantile hemangioma treated with propranolol

    PubMed Central

    Zhang, Ling; Mai, Hua-Ming; Zheng, Jing; Zheng, Jia-Wei; Chen, Zheng-Gang; Wang, Yan-An; Qin, Zhong-Ping; Li, Ke-Lei; Yuan, Wei-En

    2013-01-01

    Propranolol (PRN) has recently been recommended as the first-line medicine for complicated infantile hemangiomas (IHs), because of the significant effect. However, no pharmacokinetic parameters have ever been reported for infants who receive PRN treatment for IH. In this study, we show that plasma PRN concentration is affected by the frequency of administration of PRN. A single daily administration of PRN (1 mg/kg/d) resulted in an early elevation of plasma PRN compared to a twice a day administration of the same dose. In contrast, the twice a day application resulted in a more prolonged expression at a later time-point. Our findings provide pharmacokinetic parameters of PRN action in IH for clinic. PMID:23724152

  10. The significance of p40 expression in sclerosing hemangioma of lung

    PubMed Central

    Wu, Jian; Zhang, Chang; Qiao, Haiguo

    2014-01-01

    To explore the histogenesis of cuboidal and polygonal tumor cells in the sclerosing hemangioma of lung (SHL), eighteen cases of SHL were retrospectively studied. SPB, p40, TTF-1,EMA,CKpan, vimentin,SMA, CgA,Syn and CD34 were immunohistochemically labeled by the EnVisionmethod. It was found that the four main types of structure in SHL were solid,papillary, hemorrhagic and sclerotic patterns. The tumor cells were composed mainly of two types of cells: cuboidal tumor cells and polygonal tumor cells. The immunohistochemistry showed that p40 was expressed only in cuboidal tumor cells. TTF-1 and EMA were expressed in both polygonal cells and cuboidal cells. SPB was also expressed in cuboidal tumor cells; vimentin was expressed in all polygonal tumor cells and some cuboidal cells. The findings suggest that the p40-positive cuboidal tumor cells may be pluripotent original respiratory epithelial cells, with multi-directional differentiation capacity. PMID:25130377

  11. Cutaneous angiosarcoma arising in the radiation site of a congenital hemangioma.

    PubMed

    Caldwell, J B; Ryan, M T; Benson, P M; James, W D

    1995-11-01

    We describe a patient in whom angiosarcoma developed at the site of a hemangioma that was treated during infancy with radiation for refractory thrombocytopenia. Our findings, along with those of the 10 reported cases from the world literature, are summarized. One third of angiosarcomas arise in the skin. They most often show one of three clinical patterns. First and most common is occurrence as a bruiselike lesion on the scalp or face of an elderly person. Second in frequency is the Stewart-Treves syndrome. Third and least common is angiosarcoma developing as a sequela of previous radiation therapy. The prognosis in general is poor, with a mean survival length of 24 months and a 5-year survival rate of 10%. Effective treatment relies on early diagnosis and wide-margin surgical excision. PMID:7593798

  12. [Adult Sturge-Weber syndrome without facial hemangioma: report of one case].

    PubMed

    Zhang, Rong; Chen, Wei; Hu, Qiang; Shrestha, Sudeep

    2014-09-01

    Sturge-Weber syndrome (SWS) is characterized by angiomas affecting the ophthalmic division of the trigeminal nerve, epilepsy, intellectual impairment, hemiplegia and glaucoma. We report a patient who developed SWS without facial hemangioma (SWS type ?) in his adulthood. The patient presented with repeated episodes of headache since age 37 year. He manifested first attack of seizure at the age 47 year followed by aphasia and right upper limb palsy. Brain CT scan revealed right parietal-occipital calcification, brain CT angiography showed right temporal lobe and occipital lobe vascular malformation, and MRI showed leptomeningeal enhancement in the riht cerebral piamater. The seizure was controlled with antiepileptic drugs and reviewed in routine follow up. PMID:25372646

  13. Giant axonal neuropathy.

    PubMed

    Vijaykumar, Kadambari; Bindu, Parayil Sankaran; Taly, Arun B; Mahadevan, Anita; Bharath, Rose Dawn; Gayathri, Narayanappa; Nagappa, Madhu; Sinha, Sanjib

    2015-06-01

    Giant axonal neuropathy is an autosomal recessive disorder of childhood with distinct morphological features. An 8-year-old boy presented with progressive walking difficulty and recurrent falls. Evaluation showed frizzy hair, characteristic facies, sensory motor neuropathy, and ataxia. Magnetic resonance imaging (MRI) showed bilateral symmetric white matter signal changes in the cerebellum and periventricular regions along with involvement of the posterior limb of the internal capsule. Sural nerve biopsy demonstrated giant axons with neurofilament accumulation. The clinicopathologic manifestations of giant axonal neuropathy are discussed along with the clinical and histologic differential diagnoses. PMID:25213662

  14. Giant prostatic calculi.

    PubMed

    Najoui, Mohammed; Qarro, Abdelmounaim; Ammani, Abdelghani; Alami, Mohammed

    2013-01-01

    Prostatic parenchymal calculi are common, usually incidental, findings on morphological examinations. They are typically asymptomatic and may be present in association with normal glands, benign prostatic hyperplasia, and prostate cancer. However giant prostatic calculi are rare. Less than 20 cases have been reported in the literature. We present the case of a 35-year-old man with two giant prostatic calculi that replaced the entire gland. He underwent an open cystolithotomy, two giant stones were removed from the prostate, and we used a lithotripsy in situ for extraction of stone fragments. PMID:23565316

  15. Unstable giant gravitons

    SciTech Connect

    Mello Koch, Robert de [Department of Physics and Centre for Theoretical Physics, University of the Witwatersrand, Wits, 2050 (South Africa); Stellenbosch Institute for Advanced Studies, Stellenbosch (South Africa); Ives, Norman; Smolic, Jelena; Smolic, Milena [Department of Physics and Centre for Theoretical Physics, University of the Witwatersrand, Wits, 2050 (South Africa)

    2006-03-15

    We find giant graviton solutions in Frolov's three parameter generalization of the Lunin-Maldacena background. The background we study has {gamma}-tilde{sub 1}=0 and {gamma}-tilde{sub 2}={gamma}-tilde{sub 3}={gamma}-tilde. This class of backgrounds provides a nonsupersymmetric example of the gauge theory/gravity correspondence that can be tested quantitatively, as recently shown by Frolov, Roiban, and Tseytlin. The giant graviton solutions we find have a greater energy than the point gravitons, making them unstable states. Despite this, we find striking quantitative agreement between the gauge theory and gravity descriptions of open strings attached to the giant.

  16. PHACES syndrome: Diode laser photocoagulation of intraoral hemangiomas in six young patients

    PubMed Central

    Favia, Gianfranco; Limongelli, Luisa; Tempesta, Angela; Favia, Matteo; Maiorano, Eugenio

    2015-01-01

    Introduction The acronym PHACES describes the association of posterior fossa malformations, facial hemangiomas, arterial anomalies (cardiovascular or cerebrovascular), coarctation of the aorta and cardiac defects, eye abnormalities, and sternal or ventral defects. In this study we report on 6 patients affected by the PHACES syndrome and showing 34 intraoral hemangiomas (IH), treated by diode laser photocoagulation (DLP). Case presentation IH appeared as red-bluish soft masses, smooth or lobulated, from a few millimetre to several centimetres in size, covered by intact mucosa and blanching on pressure. IHs were treated by DLP with 320 ?m fibres at a wavelength of 800 ± 10 nm. The diode laser techniques applied were: Transmucosal DLP (DLTP), a no-contact technique in which laser energy is delivered by a flexible optic quartz fiber, which is kept 2–3 mm apart from the lesion, and Intralesional DLP (DLIP), in which the fibre is introduced into the lesion through a transmucosal access. DLTP was used for 20 flat, superficial IHs and, after a variable number of laser sessions (average = 3) depending on the size of the lesion, 65% completely regressed, while in the remaining 35% shrinkage of the lesion was achieved with minor and few complications. The remaining 14 deep/multi-lobulated IHs were treated by DLIP, resulting in complete regression of 79% of them. Conclusions DLP techniques are an effective and minimally invasive procedure for IH in patients with PHACES, in consideration of the multiple lesions to treat, of the necessity of multiple interventions and the higher compliance of the patients. PMID:25974260

  17. Surgery in extensive vertebral hemangioma: case report, literature review and a new algorithm proposal.

    PubMed

    Tarantino, Roberto; Donnarumma, Pasquale; Nigro, Lorenzo; Delfini, Roberto

    2015-07-01

    Hemangiomas are benign dysplasias or vascular tumors consisting of vascular spaces lined with endothelium. Nowadays, radiotherapy for vertebral hemangiomas (VHs) is widely accepted as primary treatment for painful lesions. Nevertheless, the role of surgery is still unclear. The purpose of this study is to propose a novel algorithm of treatment about VHs. This is a case report of an extensive VH and a review of the literature. A case of vertebral fracture during radiotherapy at a total dose of 30 Gy given in 10 fractions (treatment time 2 weeks) using a linear accelerator at 15 MV high-energy photons for extensive VH is reported. Using PubMed database, a review of the literature is done. The authors have no study funding sources. The authors have no conflicting financial interests. In the literature, good results in terms of pain and neurological deficits are reported. No cases of vertebral fractures are described. However, there is no consensus regarding the treatment for VHs. Radiotherapy is widely utilized in VHs determining pain. Surgery for VHs determining neurological deficit is also widely accepted. Perhaps, regarding the width of the lesion, no indications are given. We consider it important to make an evaluation before initiating the treatment for the risk of pathologic vertebral fracture, since in radiotherapy, there is no convention regarding structural changes determined in VHs. We propose a new algorithm of treatment. We recommend radiotherapy only for small lesions in which vertebral stability is not concerned. Kyphoplasty can be proposed for asymptomatic patients in which VHs are small and in patients affected by VHs determining pain without spinal canal invasion in which the VH is small. In patients affected by pain without spinal canal invasion but in which the VH is wide or presented with spinal canal invasion and in patients affected by neurological deficits, we propose surgery. PMID:25720346

  18. Infantile hemangioma-derived stem cells and endothelial cells are inhibited by class 3 semaphorins.

    PubMed

    Nakayama, Hironao; Huang, Lan; Kelly, Ryan P; Oudenaarden, Clara R L; Dagher, Adelle; Hofmann, Nicole A; Moses, Marsha A; Bischoff, Joyce; Klagsbrun, Michael

    2015-08-14

    Class 3 semaphorins were discovered as a family of axon guidance molecules, but are now known to be involved in diverse biologic processes. In this study, we investigated the anti-angiogenic potential of SEMA3E and SEMA3F (SEMA3E&F) in infantile hemangioma (IH). IH is a common vascular tumor that involves both vasculogenesis and angiogenesis. Our lab has identified and isolated hemangioma stem cells (HemSC), glucose transporter 1 positive (GLUT1(+)) endothelial cells (designated as GLUT1(sel) cells) based on anti-GLUT1 magnetic beads selection and GLUT1-negative endothelial cells (named HemEC). We have shown that these types of cells play important roles in hemangiogenesis. We report here that SEMA3E inhibited HemEC migration and proliferation while SEMA3F was able to suppress the migration and proliferation in all three types of cells. Confocal microscopy showed that stress fibers in HemEC were reduced by SEMA3E&F and that stress fibers in HemSC were decreased by SEMA3F, which led to cytoskeletal collapse and loss of cell motility in both cell types. Additionally, SEMA3E&F were able to inhibit vascular endothelial growth factor (VEGF)-induced sprouts in all three types of cells. Further, SEMA3E&F reduced the level of p-VEGFR2 and its downstream p-ERK in HemEC. These results demonstrate that SEMA3E&F inhibit IH cell proliferation and suppress the angiogenic activities of migration and sprout formation. SEMA3E&F may have therapeutic potential to treat or prevent growth of highly proliferative IH. PMID:26086095

  19. Hepatitis B (HBV)

    MedlinePLUS

    ... special immune injection and the first dose of hepatitis B vaccine at birth. How Is It Prevented? Because people ... B virus. Doctors recommend that teens get a hepatitis B immunization (vaccine). It's a series of three shots over a ...

  20. Hepatitis C (image)

    MedlinePLUS

    Hepatitis C is a virus-caused liver inflammation which may cause jaundice, fever and cirrhosis. Persons who are most at risk for contracting and spreading hepatitis C are those who share needles for injecting drugs ...

  1. The Giant Cell.

    ERIC Educational Resources Information Center

    Stockdale, Dennis

    1998-01-01

    Provides directions for the construction of giant plastic cells, including details for building and installing the organelles. Also contains instructions for preparing the ribosomes, nucleolus, nucleus, and mitochondria. (DDR)

  2. Hepatitis B and Hepatitis C in Pregnancy

    MedlinePLUS

    ... any symptoms. In a small number of carriers, chronic infection can lead to serious complications, such as cirrhosis of the liver, liver cancer, and early death. Can hepatitis B virus infection be cured? There is no cure for hepatitis B virus infection, but symptoms can ...

  3. Enhancement characteristics of liver metastases, hepatocellular carcinomas, and hemangiomas with Gd-EOB-DTPA: preliminary results with dynamic MR imaging

    Microsoft Academic Search

    P. Reimer; E. J. Rummeny; H. E. Daldrup; T. Hesse; T. Balzer; B. Tombach; P. E. Peters

    1997-01-01

    .   Our objective was to study Gd-EOB-DTPA for the characterization of focal liver lesions by means of dynamic MR imaging. A\\u000a double-blind and randomized dose-ranging phase-2 clinical trial was performed in 31 patients (liver metastases n = 23, hepatocellular carcinoma n = 4, and hemangioma n = 4) at a field strength of 1.0 Tesla. Gd-EOB-DTPA (Schering AG, Berlin, Germany)

  4. Capillary Hemangioma

    MedlinePLUS

    ... 03/2015 Eye Terms & Conditions Most Common Searches Adult Strabismus Amblyopia Cataract Conjunctivitis Corneal Abrasions Dilating Eye Drops Lazy ... Screening Vision Screening Recommendations Loading... Most Common Searches Adult ... Abrasions Dilating Eye Drops Lazy ...

  5. Pathogenesis of Hepatic Encephalopathy

    PubMed Central

    Cie?ko-Michalska, Irena; Szczepanek, Ma?gorzata; S?owik, Agnieszka; Mach, Tomasz

    2012-01-01

    Hepatic encephalopathy can be a serious complication of acute liver failure and chronic liver diseases, predominantly liver cirrhosis. Hyperammonemia plays the most important role in the pathogenesis of hepatic encephalopathy. The brain-blood barrier disturbances, changes in neurotransmission, neuroinflammation, oxidative stress, GABA-ergic or benzodiazepine pathway abnormalities, manganese neurotoxicity, brain energetic disturbances, and brain blood flow abnormalities are considered to be involved in the development of hepatic encephalopathy. The influence of small intestine bacterial overgrowth (SIBO) on the induction of minimal hepatic encephalopathy is recently emphasized. The aim of this paper is to present the current views on the pathogenesis of hepatic encephalopathy. PMID:23316223

  6. Primary hepatic neuroendocrine tumor with multiple liver metastases: A case report with review of the literature

    PubMed Central

    Yang, Kai; Cheng, Ying-Sheng; Yang, Ji-Jin; Jiang, Xu; Guo, Ji-Xiang

    2015-01-01

    We herein present a case involving a 41-year-old woman in whom ultrasound examination revealed multiple liver hemangiomas more than 3 years ago. Follow-up ultrasound examination revealed that the masses had significantly increased; the largest was located in the right lobe (about 8.2 cm × 7.4 cm × 6.0 cm). Abdominal multidetector computed tomography revealed multiple well-circumscribed, heterogeneous, hypodense masses (largest, 6.4 cm × 6.3 cm × 5.0 cm) with significant contrast enhancement during the arterial and portal phases and with contrast wash-out and peripheral enhancement during the delayed phases. Magnetic resonance images demonstrated multiple well-circumscribed, heterogeneous, hypointense hepatic masses with significant contrast enhancement (largest, 6.4 cm × 6.5 cm × 5.1 cm); multiple enlarged porta lymph nodes; and multiple slightly enlarged retroperitoneal lymph nodes. Histological and immunohistochemical examination of the right mass biopsy specimen suggested a malignant neoplasm that had originated from a neuroendocrine cell type (grade 2 well-differentiated neuroendocrine carcinoma). After performing a systemic examination to exclude metastasis from an extrahepatic primary site, we considered that the masses had arisen from a primary hepatic neuroendocrine tumor with multiple liver metastases. The patient underwent transcatheter arterial chemoembolization using a combination of oxaliplatin (150 mg) mixed with one bottle of gelatin sponge particles (560-710 ?m) and lipiodol (6 mL). Primary neuroendocrine tumors of the liver are extremely rare. This case is interesting because of the rarity of this neoplasm and previous misdiagnosis as multiple liver hemangiomas. Previously reported cases in the literature are also reviewed. PMID:25780316

  7. Giant congenital melanocytic nevus*

    PubMed Central

    Viana, Ana Carolina Leite; Gontijo, Bernardo; Bittencourt, Flávia Vasques

    2013-01-01

    Giant congenital melanocytic nevus is usually defined as a melanocytic lesion present at birth that will reach a diameter ? 20 cm in adulthood. Its incidence is estimated in <1:20,000 newborns. Despite its rarity, this lesion is important because it may associate with severe complications such as malignant melanoma, affect the central nervous system (neurocutaneous melanosis), and have major psychosocial impact on the patient and his family due to its unsightly appearance. Giant congenital melanocytic nevus generally presents as a brown lesion, with flat or mammilated surface, well-demarcated borders and hypertrichosis. Congenital melanocytic nevus is primarily a clinical diagnosis. However, congenital nevi are histologically distinguished from acquired nevi mainly by their larger size, the spread of the nevus cells to the deep layers of the skin and by their more varied architecture and morphology. Although giant congenital melanocytic nevus is recognized as a risk factor for the development of melanoma, the precise magnitude of this risk is still controversial. The estimated lifetime risk of developing melanoma varies from 5 to 10%. On account of these uncertainties and the size of the lesions, the management of giant congenital melanocytic nevus needs individualization. Treatment may include surgical and non-surgical procedures, psychological intervention and/or clinical follow-up, with special attention to changes in color, texture or on the surface of the lesion. The only absolute indication for surgery in giant congenital melanocytic nevus is the development of a malignant neoplasm on the lesion. PMID:24474093

  8. Nutritional management of hepatic disease.

    PubMed

    Bauer, J E; Schenck, P A

    1989-05-01

    The successful management of hepatic diseases of dogs and cats requires an understanding of hepatic metabolism and nutritional processes. General aspects of dietary therapy for hepatic diseases are described, along with specific recommendations for the promotion of tissue regeneration. Special considerations, including the role of diet in encephalopathy, hepatic lipidosis, and copper-associated hepatic toxicosis, are also discussed. PMID:2658288

  9. [Extracranial vascular anomalies (hemangiomas and vascular malformations) in children and adolescents--diagnosis, clinic, and therapy].

    PubMed

    Eivazi, B; Werner, J A

    2014-03-01

    The field of extracranial vascular anomalies is considered as special focus of pediatric otolaryngology and it has shown a rapid development during the last years. The reason for this interest is finally also due to the global acceptance of the classification introduced by the ISSVA (International Society for the Study of Vascular Anomalies). Hemangiomas are the most frequently observed vascular tumors. Today the systemic propranolol therapy is mostly used for therapy of hemangiomas requiring treatment. Increasingly, the topical application of beta blocker is discussed while the benefit in the head and neck seems to be limited. Vascular malformations are classified according to the morphology of the affected part of the vascular system in arterial, venous, arterio-venous, lymphatic, capillary, and combined vascular malformations. Conventional surgery, sclerosing therapy, and laser treatment are invasive options for the treatment of lymphatic malformations. The options for the treatment of venous malformations could be significantly improved during the last years. In this context, the use of Nd:YAG laser, the conservative treatment of the localized disseminated intravascular coagulation with low-molecular weight heparin, the re-discovery of bleomycin as effective sclerosing agent, and the improvement of alcohol-based embolization agents must be mentioned. Today the treatment with dye laser is the preferred therapy for capillary malformations and it is superior to other therapeutic options as for example photodynamic therapy. Arterio-venous malformations as representatives for high-flow lesions are the high-risk lesions. Frequently they are compared to malignant head and neck tumors, in particular when a curative treatment can no longer be assured because of diffuse or multifocal extent and when the disease shows a progressive course. The combined treatment of embolization and surgical resection and if necessary consecutive defect reconstruction have turned out to be appropriate for arterio-venous malformations. Incurable findings are still a major challenge. Despite the introduction of antiangiogenetic drugs in oncology, the medicamentous therapeutic approach could not be established for arterio-venous malformations up to now. PMID:24710783

  10. Extracranial vascular malformations (hemangiomas and vascular malformations) in children and adolescents - diagnosis, clinic, and therapy.

    PubMed

    Eivazi, Behfar; Werner, Jochen A

    2014-01-01

    The field of extracranial vascular anomalies is considered as special focus of pediatric otolaryngology and it has shown a rapid development during the last years. The reason for this interest is finally also due to the global acceptance of the classification introduced by the ISSVA (International Society for the Study of Vascular Anomalies). Hemangiomas are the most frequently observed vascular tumors. Today the systemic propranolol therapy is mostly used for therapy of hemangiomas requiring treatment. Increasingly, the topical application of beta blocker is discussed while the benefit in the head and neck seems to be limited. Vascular malformations are classified according to the morphology of the affected part of the vascular system in arterial, venous, arterio-venous, lymphatic, capillary, and combined vascular malformations. Conventional surgery, sclerosing therapy, and laser treatment are invasive options for the treatment of lymphatic malformations. The options for the treatment of venous malformations could be significantly improved during the last years. In this context, the use of Nd:YAG laser, the conservative treatment of the localized disseminated intravascular coagulation with low-molecular weight heparin, the re-discovery of bleomycin as effective sclerosing agent, and the improvement of alcohol-based embolization agents must be mentioned. Today the treatment with dye laser is the preferred therapy for capillary malformations and it is superior to other therapeutic options as for example photodynamic therapy. Arterio-venous malformations as representatives for high-flow lesions are the high-risk lesions. Frequently they are compared to malignant head and neck tumors, in particular when a curative treatment can no longer be assured because of diffuse or multifocal extent and when the disease shows a progressive course. The combined treatment of embolization and surgical resection and if necessary consecutive defect reconstruction have turned out to be appropriate for arterio-venous malformations. Incurable findings are still a major challenge. Despite the introduction of antiangiogenetic drugs in oncology, the medicamentous therapeutic approach could not be established for arterio-venous malformations up to now. PMID:25587362

  11. Lesion discrimination with breath-hold hepatic diffusion-weighted imaging: A meta-analysis

    PubMed Central

    Chen, Zhi-Guang; Xu, Li; Zhang, Si-Wei; Huang, Yan; Pan, Rui-Huan

    2015-01-01

    AIM: To investigate the diagnostic capability of breath-hold diffusion-weighted imaging (DWI) for differentiation between malignant and benign hepatic lesions. METHODS: A total of 614 malignant liver lesions (132 hepatocellular carcinomas, 468 metastases and 14 intrahepatic cholangiocarcinomas) and 291 benign liver lesions (102 hemangiomas, 158 cysts, 24 focal nodular hyperplasia, 1 angiomyolipoma and 6 hepatic adenomas) were included from seven studies (eight sets of data). RESULTS: The pooled sensitivity and specificity of breath-hold DWI were 0.93 [95% confidence interval (CI): 0.91-0.95] and 0.87 (95%CI: 0.83-0.91), respectively. The positive likelihood ratio and negative likelihood ratio were 7.28 (95%CI: 4.51-11.76) and 0.09 (95%CI: 0.05-0.17), respectively. The P value for ?2 heterogeneity for all pooled estimates was < 0.05. From the fitted summary receiver operating characteristic curve, the area under the curve and Q* index were 0.96 and 0.91, respectively. Publication bias was not present (t = 0.49, P = 0.64). The meta-regression analysis indicated that evaluated covariates including magnetic resonance imaging modality, echo time, mean age, maximum b factor, and number of b factors were not sources of heterogeneity (all P > 0.05). CONCLUSION: Breath-hold DWI is useful for differentiating between malignant and benign hepatic lesions. The diffusion characteristics of benign lesions that mimic malignant ones have rarely been investigated. PMID:25663782

  12. Giant perigenital seborrheic keratosis

    PubMed Central

    Bandyopadhyay, Debabrata; Saha, Abanti; Mishra, Vivek

    2015-01-01

    Seborrheic keratosis (SK) is a very common benign epidermal proliferation that is prevalent in all races. Most commonly occurring on the trunk, face, scalp, and the extremities, they can occur anywhere on the body except the palms and soles. The most common appearance is that of a very superficial verrucous plaque which appears to be stuck on the surface. Giant lesions are very rare, and their location on the genital area is rarer still. We report here a case of multiple giant SK lesions in a 59-year-old man. PMID:25657917

  13. Congenital giant melanocytic nevi

    PubMed Central

    Hashmi, Ghulam S; Ahmed, Syed S; Khan, Shahla

    2009-01-01

    Nevi are common skin tumors caused by abnormal overgrowth of cells from the epidermal and dermal layers of the skin. Most nevi are benign, but some pre-cancerous nevi must be monitored or removed. The giant congenital nevus is greater than 10 cm in size, pigmented and often hairy. Between 4% and 6% of these lesions will develop into a malignant melanoma. Since approximately 50% of the melanoma develop by the age of two, and 80% by the age of seven, early removal is recommended. The objective of this paper is to present a unique case of giant nevi and their surgical management. PMID:21139903

  14. GIANT CUTANEOUS HORN

    PubMed Central

    Kumaresan, M; Kumar, Pramod; Pai, Manohar Varadharaj

    2008-01-01

    A 53-year-old male presented with a giant cutaneous horn over the left leg. Cutaneous horn was excised and primary closure of the defect was done under spinal anesthesia. Histopathology showed underlying seborrheic keratosis. Cutaneous horn has been noticed on top of many clinical conditions of diverse etiology, such as actinic keratoses, wart, molluscum contagiosum, seborrheic keratoses, keratoacanthoma, basal cell and squamous cell carcinoma. We report a patient with giant cutaneous horn on the leg successfully treated by excision and wound closure. PMID:19882036

  15. Multifrequency 'giant' photopleochroism

    NASA Astrophysics Data System (ADS)

    Medvedkin, G. A.; Rud', Iu. V.; Tairov, M. A.

    1988-05-01

    An experimental observation of multifrequency 'giant' photopleochroism in polarimetric diode structures based on II-IV-V(2) crystals with a chalcopyrite lattice (e.g., CdO/Al2O3/CdSnP2) is reported. The fabrication of the structures and details of the experimental procedure are briefly discussed, and a typical spectrum of the photopleochroism coefficient of the CdO/Al2O3/CdSnP2 structure, calculated for spectral photoresponse measurements at 300 K, is shown. The effect of multifrequency giant photopleochroism can be used in high-frequency polarimetric null indicators operating at several fixed wavelengths.

  16. Viral Hepatitis D

    Microsoft Academic Search

    John M. Taylor

    \\u000a Viral hepatitis D, also known as hepatitis delta virus (HDV), was first discovered by Mario Rizzetto in 1977, in a study of\\u000a Italian patients infected with hepatitis B virus (HBV), who seemed to have a more damaging liver disease. For more information\\u000a on HBV, please see Chap. 37. In liver biopsies from such patients, a serum antibody detected a novel

  17. Characterizing infantile hemangiomas with a near-infrared spectroscopic handheld wireless device

    NASA Astrophysics Data System (ADS)

    Fong, Christopher J.; Hoi, Jennifer W.; Kim, Hyun K.; Behr, Gerald; Geller, Lauren; Antonov, Nina; Flexman, Molly; Garzon, Maria; Hielscher, Andreas H.

    2015-03-01

    Infantile hemangiomas (IH) are common vascular growths that occur in 5-10% of neonates and have the potential to cause disfiguring and even life-threatening complications. Currently, no objective tool exist to monitor either progression or treatment of IH. To address this unmet clinical need, we have developed a handheld wireless device (HWD) that uses diffuse optical spectroscopy for the assessment of IH. The system employs 4 wavelengths (l=780nm, 805nm, 850nm, and 905nm) and 6 source-detector pairs with distances between 0.6 and 20 mm. Placed on the skin surface, backreflection data is obtained and a multispectral evolution algorithm is used to determine total hemoglobin concentration and tissue oxygen saturation. First results of an ongoing pilot study involving 13 patients (average enrollment age = 25 months) suggest that an increase in hypoxic stress over time can lead to the proliferation of IH. Involuting IH lesions showed an increase in tissue oxygen saturation as well as a decrease in total hemoglobin.

  18. Formulation, characterization and clinical evaluation of propranolol hydrochloride gel for transdermal treatment of superficial infantile hemangioma.

    PubMed

    Zhou, Wenhu; He, Shiying; Yang, Yijun; Jian, Dan; Chen, Xiang; Ding, Jinsong

    2015-07-01

    The objective of the present study is to formulate and characterize propranolol hydrochloride (PPL?·?HCl) gel, and to evaluate the efficacy of this formulation in transdermal treatment for superficial infantile hemangioma (IH). The transdermal PPL?·?HCl gel was prepared by a direct swelling method, which chose hydroxypropyl methylcellulose (HPMC) as the matrix and used terpenes plus alcohols as permeation enhancer. Permeation studies of PPL?·?HCl were carried out with modified Franz diffusion cells through piglet skin. Our results pointed to that among all studied permeation enhancers, farnesol plus isopropanol was the most effective combination (Q24, 6027.4?±?563.1??g/cm(2), ER, 6.8), which was significantly higher than that of control gel (p?

  19. Pericytes from Infantile Hemangioma Display Pro-angiogenic Properties and Dysregulated Angiopoietin-1

    PubMed Central

    Boscolo, Elisa; Mulliken, John B.; Bischoff, Joyce

    2013-01-01

    OBJECTIVE Infantile hemangioma (IH) is a rapidly growing vascular tumor affecting newborns. It is composed of immature endothelial cells and pericytes that proliferate into a disorganized mass of blood vessels. We isolated pericytes from IH (Hem-pericytes) to test our hypothesis that Hem-pericytes are unable to stabilize blood vessels. METHODS AND RESULTS We injected pericytes in vivo, in combination with endothelial cells, and found that Hem-pericytes formed more microvessels compared to control retinal pericytes. We thereby analyzed pro-angiogenic properties of the Hem-pericytes. They grew fast in vitro, and were unable to stabilize endothelial cell growth and migration, and expressed high levels of VEGF-A compared to retinal pericytes. Hem-pericytes from proliferating phase IH showed lower contractility in vitro, compared to Hem-pericytes from the involuting phase and retinal pericytes. Consistent with a diminished ability to stabilize endothelium, Angiopoietin 1 (ANGPT1) was reduced in Hem-pericytes compared to retinal pericytes. Normal retinal pericytes in which ANGPT1 was silenced produced conditioned medium that stimulated endothelial cell proliferation and migration. CONCLUSIONS We report the first successful isolation of patient-derived pericytes from IH tissue. Hem-pericytes exhibited pro-angiogenic properties and low levels of ANGPT1, consistent with a diminished ability to stabilize blood vessels in IH. PMID:23288163

  20. Hemorrhagic giant cystic lymphangioma of the liver in an adult female

    PubMed Central

    Nakano, Tomotsugu; Hara, Yoshiaki; Shirokawa, Masamitsu; Shioiri, Sadaaki; Goto, Hideaki; Yasuno, Masamichi; Tanaka, Michio

    2015-01-01

    An 18-year-old woman who presented with epigastric pain was diagnosed with rupture of a hepatic tumor and transported to our hospital. Contrast-enhanced computed tomography revealed a 13-cm, low-density giant mass in the left hepatic lobe and high-density ascites, indicating abdominal bleeding from the liver tumor. The patient underwent emergent celiac angiography, and the left hepatic artery, which was believed to feed the tumor, was embolized. After the patient's condition stabilized, she underwent left hepatic lobectomy. In addition, the enlarged lymph nodes of the hepatoduodenal ligament were dissected. On microscopic examination, immunohistochemical staining revealed that both the liver cyst and the enlarged lymph node were positive for the endothelial marker CD31 and lymphangial marker D2-40. The patient was pathologically diagnosed with cystic lymphangioma of the liver. She has now been followed up for almost 4 years after surgery without any sign of recurrence. PMID:25832463

  1. Giant lymphatic malformation

    Microsoft Academic Search

    Sharon Tamir; Ronit Agid; Doron Halperin; Jean-Yves Sichel

    2006-01-01

    Lymphatic malformations (LM) are rare, often presenting as congenital abnormal growth of lymphatic vessels diagnosed most commonly in the pediatric population.We report a case of an adult women presenting with a giant LM of the neck and mediastinum reaching the upper part of the retroperitoneum, manifesting itself as bilateral supraclavicular neck masses accompanied with an abdominal mass.

  2. Congenital segmental giant megaureter

    Microsoft Academic Search

    S Ramaswamy; V Bhatnagar; D. K Mitra; A. K Gupta

    1995-01-01

    A case of congenital segmental giant megaureter is reported. The patient presented with an asymptomatic abdominal mass resulting from the megaureter. A mildly hydronephrotic ipsilateral kidney was palpable as a separate mass. The ureter proximal and distal to the dilated segment showed normal peristaltic activity. Treatment consisted of excision of the dilated segment, with end-to-end ureteric anastomosis.

  3. Giant mesenteric lipoma

    Microsoft Academic Search

    Hüseyin Ilhan; Baran Tokar; Naim Koku; Özgül Pasaoglu

    1999-01-01

    Mesenteric lipoma is a rare benign tumor of mature fat cells. Asymptomatic abdominal mass, progressive abdominal distension, and intraperitoneal radiolucent fat density mass on computed tomography are the main diagnostic criteria. Main differential diagnosis is lipoblastoma or lipoblastomosis. Treatment is surgical excision. As an unusual case, a 3-year-old boy with a giant mesenteric lipoma is presented in this report.

  4. Birth control for giants

    Microsoft Academic Search

    Joel H. Spencer; Nicholas C. Wormald

    2007-01-01

    The standard Erdýos-Renyi model of random graphs begins with n isolated vertices, and at each round a random edge is added. Parametrizing n 2 rounds as one time unit, a phase transition occurs at t = 1 when a giant component (one of size constant time n) first appears. Under the influence of statistical mechanics, the investigation of related phase

  5. Finite size giant magnon

    SciTech Connect

    Ramadanovic, Bojan; Semenoff, Gordon W. [Department of Physics and Astronomy, University of British Columbia, Vancouver, British Columbia, V6T 1Z1 (Canada)

    2009-06-15

    The quantization of the giant magnon away from the infinite size limit is discussed. We argue that this quantization inevitably leads to string theory on a Z{sub M} orbifold of S{sup 5}. This is shown explicitly and examined in detail in the near plane-wave limit.

  6. Posttraumatic giant renal pseudoaneurysm

    Microsoft Academic Search

    Rodrigo Pastorín; Nuria Rodríguez; Ana María Polo; José Manuel Vicente; Marcos Luján

    2007-01-01

    Renal artery pseudoaneurysms secondary to blunt abdominal trauma are uncommon. We report a giant renal pseudoaneurysm, diagnosed\\u000a by computerized tomography 5 months after a blunt trauma, which was confirmed by catheter angiography and treated with selective\\u000a embolization.

  7. Finite Size Giant Magnon

    E-print Network

    Bojan Ramadanovic; Gordon W. Semenoff

    2008-04-08

    The quantization of the giant magnon away from the infinite size limit is discussed. We argue that this quantization inevitably leads to string theory on a Z_M-orbifold of S^5. This is shown explicitly and examined in detail in the near plane-wave limit.

  8. A Council of Giants

    NASA Astrophysics Data System (ADS)

    McCall, Marshall L.

    2014-05-01

    Distances and near-infrared luminosities of the brightest galaxies in the Local Volume have been re-evaluated in order to gain a fully homogeneous collection of data for elucidating the framework of the Local Sheet and its relevance to Local Group evolution. It is demonstrated that the Local Sheet is both geometrically and dynamically distinct from the Local Supercluster and that the evolution of the Sheet and Local Group were probably interconnected. The Sheet is inclined by 8° with respect to the Local Supercluster, and the dispersion of giant members about the mid-plane is only 230 kpc. A `Council of Giants' with a radius of 3.75 Mpc encompasses the Local Group, demarcating a clear upper limit to the realm of influence of the Local Group. The only two giant elliptical galaxies in the Sheet sit on opposite sides of the Council, raising the possibility that they have somehow shepherded the evolution of the Local Group. The position vector of the Andromeda galaxy with respect to the Milky Way deviates only 11° from the Sheet plane and only 11° from the projected axis of the ellipticals. The Local Group appears to be moving away from a ridge in the potential surface of the Council on a path parallel to the elliptical axis. Spin directions of the giants in the Council are distributed over the sky in a pattern which is very different from that of giants beyond, possibly in reaction to the central mass asymmetry that developed into the Local Group. By matching matter densities of Group and Council giants, the edge of the volume of space most likely to have contributed to the development of the Local Group is shown to be very close to where gravitational forces from the Local Group and the Council balance. The boundary specification reveals that the Local Sheet formed out of a density perturbation of very low amplitude (˜10 per cent), but that normal matter was incorporated into galaxies with relatively high efficiency (˜40 per cent). It appears that the development of the giants of the Local Sheet was guided by a pre-existing flattened framework of matter.

  9. [Hepatic artery embolization for primary hepatic carcinoma].

    PubMed

    Ye, W J

    1989-03-01

    Twenty patients with primary hepatic carcinoma (PHC) treated by hepatic arterial embolization in our department from Dec. 1986 to Mar. 1987 are reported. There were 15 males and 5 females. The ages ranged from 34 to 75 years with an average of 50.7. Preoperative diagnosis and localization of the tumor were done by AFP, B-us, CT and angiography (right lobe 15 cases, left lobe 1 case, both lobes 4 cases). Celiac and superior mesenteric angiography was carried out by femoral artery approach and then highly selective hepatic catheterization was utilized for hepatic arterial embolization. Antitumor agent (5-Fu, adriamycin), iophendylate and foamy gel sponge were used for peripheral and proximal embolization. Manifestations were improved in most of the patients after embolization, such as relief of abdominal pain, improvement of appetite, decrease of tumor size. Total necrosis of the tumor was found in 2 patients who underwent surgery 1 month after embolization. The side effects of the posthepatic embolization such as, nausea, vomiting, abdominal pain and fever could be relieved by symptomatic treatment. No severe complications, such as gangrene of the gall bladder, hepatic failure, liver abscess, intestinal necrosis or pulmonary embolization were found except 3 patients who died of renal failure after the procedure. The liver dys-function returned to normal within 2 weeks. Hepatic arterial embolization provides an alternative treatment for the patients with PHC who has compensated liver function without severe systemic diseases, especially renal endocrine problems and severe portal hypertension. They should have patent portal system as proved by angiography. The authors considered that this therapeutic embolization with hepatic chemotherapy infusion is safe and effective in the management of PHC. It may increase the resectability and provide palliative means for the advanced and terminal cases. PMID:2553366

  10. Simultaneous giant hydatid cysts of brain and liver.

    PubMed

    Ijaz, Lubna; Mirza, Bilal; Nadeem, Malik Muhammad; Saleem, Muhammad

    2015-04-01

    While hepatic hydatid cysts are most common in occurrence, intracranial hydatid cyst is less common. Simultaneous presence of both varieties is quite rare and poses a challenge for management in terms of involvement of multidisciplinary team and multiple interventions. An 8-year boy presented with neurological symptoms of a space occupying lesion. There was also hepatomegaly. Radiological investigations revealed giant hydatid cysts involving left cerebral hemisphere and left lobe of liver. Cerebral hydatid cyst was operated first by pediatric neurosurgeons. After 10 days of stabilization period, hepatic lesion was removed by pediatric surgeons. Patient showed uneventful recovery and discharged on oral albendazole for 6 months. There was no recurrence at follow-up. PMID:25933466

  11. Enhancement characteristics of liver metastases, hepatocellular carcinomas, and hemangiomas with Gd-EOB-DTPA: preliminary results with dynamic MR imaging.

    PubMed

    Reimer, P; Rummeny, E J; Daldrup, H E; Hesse, T; Balzer, T; Tombach, B; Peters, P E

    1997-01-01

    Our objective was to study Gd-EOB-DTPA for the characterization of focal liver lesions by means of dynamic MR imaging. A double-blind and randomized dose-ranging phase-2 clinical trial was performed in 31 patients (liver metastases n = 23, hepatocellular carcinoma n = 4, and hemangioma n = 4) at a field strength of 1.0 Tesla. Gd-EOB-DTPA (Schering AG, Berlin, Germany) was administered as an IV bolus (12.5, 25, or 50 micromol/kg body weight) with dynamic T1-weighted MRI during the distribution and cellular uptake of the contrast agent at multiple time points up to 45 min post contrast. Dynamic changes in tumor signal intensity, tumor-liver contrast, enhancement patterns, side effects, and adverse events were evaluated. Monitoring of vital signs revealed no significant changes during bolus injection of Gd-EOB-DTPA. Liver metastases demonstrated an inhomogeneous uptake of Gd-EOB-DTPA during the distribution phase with a washout effect on delayed images > 3 min and highest tumor-liver contrast 20 and 45 min post contrast. Hepatocellular carcinomas showed prolonged enhancement as compared with metastases and hemangiomas. Hemangiomas exhibited an early peripheral-nodular enhancement with subsequent partial or complete filling, persisting enhancement < 10 min following injection of Gd-EOB-DTPA, and delayed washout as compared with liver metastases. Initial clinical experience suggests that Gd-EOB-DTPA as a bolus injectable hepatobiliary MR contrast agent may offer useful features for the characterization of focal liver lesions. PMID:9038130

  12. E-Selectin Mediates Stem Cell Adhesion and Formation of Blood Vessels in a Murine Model of Infantile Hemangioma

    PubMed Central

    Smadja, David M.; Mulliken, John B.; Bischoff, Joyce

    2013-01-01

    Hemangioma stem cells (HemSCs) are multipotent cells isolated from infantile hemangioma (IH), which form hemangioma-like lesions when injected subcutaneously into immune-deficient mice. In this murine model, HemSCs are the primary target of corticosteroid, a mainstay therapy for problematic IH. The relationship between HemSCs and endothelial cells that reside in IH is not clearly understood. Adhesive interactions might be critical for the preferential accumulation of HemSCs and/or endothelial cells in the tumor. Therefore, we studied the interactions between HemSCs and endothelial cells (HemECs) isolated from IH surgical specimens. We found that HemECs isolated from proliferating phase IH, but not involuting phase, constitutively express E-selectin, a cell adhesion molecule not present in quiescent endothelial cells. E-selectin was further increased when HemECs were exposed to vascular endothelial growth factor–A or tumor necrosis factor–?. In vitro, HemSC migration and adhesion was enhanced by recombinant E-selectin but not P-selectin; both processes were neutralized by E-selectin–blocking antibodies. E-selectin–positive HemECs also stimulated migration and adhesion of HemSCs. In vivo, neutralizing antibodies to E-selectin strongly inhibited formation of blood vessels when HemSCs and HemECs were co-implanted in Matrigel. These data suggest that endothelial E-selectin could be a major ligand for HemSCs and thereby promote cellular interactions and vasculogenesis in IH. We propose that constitutively expressed E-selectin on endothelial cells in the proliferating phase is one mediator of the stem cell tropism in IH. PMID:23041613

  13. Giant biliary cystadenoma complicated with polycystic liver: A case report

    PubMed Central

    Yang, Zhen-Zhen; Li, Yong; Liu, Jun; Li, Kuang-Fan; Yan, Ye-Hong; Xiao, Wei-Dong

    2013-01-01

    Biliary cystadenoma (BCA) is a rare hepatic neoplasm. Although considered a benign cystic tumor of the liver, BCA has a high risk of recurrence with incomplete excision and a potential risk for malignant degeneration. Correct diagnosis and complete tumor excision with negative margins are the mainstay of treatment. Unfortunately, due to the lack of presenting symptoms, and normal laboratory results in most patients, BCA is hard to distinguish from other cystic lesions of the liver such as biliary cystadenocarcinoma, hepatic cyst, hydatid cyst, Caroli disease, undifferentiated sarcoma, intraductal papillary mucinous tumor, and hepatocellular carcinoma. Ultrasound (US), computed tomography (CT) and magnetic resonance imaging (MRI) may be necessary. They demonstrate intrahepatic cystic lesions with features such as mural nodules, varying wall thickness, papillary projections, and internal septations. Nevertheless, surgery is still the only means of accurate diagnosis. Definitive diagnosis requires histological examination following formal resection. We describe a 57-year-old woman initially diagnosed with polycystic liver who was subsequently diagnosed with giant intrahepatic BCA in the left hepatic lobe. This indicates that both US physicians and hepatobiliary specialists should attach importance to hepatic cysts, and CT or MRI should be performed for further examination when a diagnosis of BCA is suspected. PMID:24115833

  14. Hepatitis Foundation International

    MedlinePLUS

    ... profit organization established in 1994 working to eradicate chronic hepatitis for 400 million people globally. HFI is also ... Your Information. Our best hope for treatments and cures is your participation in the Hepatitis Foundation International Registry. Whether you are affected, a ...

  15. Alcohol and Hepatitis C

    Microsoft Academic Search

    M. Mazen Jamal; Zainab Saadi; Timothy R. Morgan

    2005-01-01

    Background\\/Aims: Alcohol use and hepatitis C are prominent risk factors for liver injury and this review offers the current understanding of each factor’s effects on liver disease. Methods: A Medline database search was preformed for English articles with a focus on alcohol, hepatitis C and liver disease. Article citations were also considered for further applicable articles, and the strongest studies

  16. Transumbilical Single-Incision Laparoscopic Resection of Focal Hepatic Lesions

    PubMed Central

    Yu, Xiao-Peng; Tian, Yu; Siwo, Ernest Amos; Li, Yongnan; Yu, Hong; Yao, Dianbo; Lv, Chao

    2014-01-01

    Background and Objectives: Transumbilical single-incision laparoscopic surgery (SILS) is gaining in popularity as a minimally invasive technique. The reduced pain and superior cosmetic appearance it affords make it attractive to many patients. For this study, we focused on SILS, analyzing the outcomes of transumbilical single-incision laparoscopic liver resection (SILLR) achieved at our institution between January 2010 and February 2013. Patients and Methods: Pre- and postoperative data from 17 patients subjected to transumbilical SILLR for various hepatic lesions (8 hemangiomas, 2 hepatocellular carcinomas, 2 metastases, 2 calculi of left intrahepatic duct, and 3 adenomas) were assessed. Altogether, eight wedge resections, seven left lateral lobectomies, a combination wedge resection/left lateral lobectomy, and a proximal left hemihepatectomy segmentectomy were performed, as well as four simultaneous laparoscopic cholecystectomies. In each instance, three ports were installed through an umbilical incision. Once vessels and bleeding were controlled, the lesion(s) were resected with 5-mm margins of normal liver. Resected tissues were then bagged and withdrawn through the umbilical incision. The follow-up period lasted for a minimum of 6 months. Results: All 17 patients were successfully treated through a single umbilical incision. The procedures required 55 to 185 minutes to complete, with blood loss of 30 to 830 mL. Subjects regained bowel activity 0.8 to 2.3 days postoperatively and were discharged after 3 to 10 days. There were few complications (23.5%), limited to pleural effusion, wound infection, and incisional hernia. Conclusions: Transumbilical SILLR is challenging to perform through conventional laparoscopic instrumentation. The risk of bleeding and technical difficulties is high for lesions of the posterosuperior hepatic segment. Surgical candidates should be carefully selected to optimize the benefits of this technique. PMID:25392646

  17. Hepatitis E virus infection in acute hepatitis in Spain

    Microsoft Academic Search

    Maria Buti; Rosendo Jardí; Montserrat Cotrina; Francisco Rodríguez-Frías; Hugo Troonen; Luis Viladomiu; J. I. Esteban; Rafael Esteban; Jaime Guardia

    1995-01-01

    In order to study the prevalence of hepatitis E virus (HEV) infection in developed countries, IgG and IgM anti-HEV were determined in serum samples from 382 patients with acute viral hepatitis (244 hepatitis A, 48 hepatitis B and\\/or D, and 90 non-A, non-B, non-C hepatitis), 76 healthy subjects, 55 hemophiliacs and 50 patients on hemodialysis. IgG anti-HEV antibodies were detected

  18. Giant cell arteritis

    PubMed Central

    Calvo-Romero, J

    2003-01-01

    Giant cell arteritis (GCA), temporal arteritis or Horton's arteritis, is a systemic vasculitis which involves large and medium sized vessels, especially the extracranial branches of the carotid arteries, in persons usually older than 50 years. Permanent visual loss, ischaemic strokes, and thoracic and abdominal aortic aneurysms are feared complications of GCA. The treatment consists of high dose steroids. Mortality, with a correct treatment, in patients with GCA seems to be similar that of controls. PMID:13679546

  19. Subependymal giant cell astrocytoma

    Microsoft Academic Search

    J. M. Bonnin; L. J. Rubinstein; S. Ch. Papasozomenos; P. J. Marangos

    1984-01-01

    Twenty-two cases of subependymal giant cell astrocytoma (SGCA), five of which associated with tuberous sclerosis, were reviewed by conventional neurohistological stains and by peroxidase-antiperoxidase (PAP) immunohistochemistry for glial fibrillary acidic (GFA) protein, the 68 Kd neurofilament subunit (68 Kd-NF), and neuron-specific enolase (NSE). Neurohistological stains confirmed the presence of PTAH-positive fibrils and the absence of Nissl bodies and of neurites

  20. Giant bubble-pinchoff

    Microsoft Academic Search

    Raymond Bergmann; Devaraj van der Meer; Mark Stijnman; Marijn Sandtke; Andrea Prosperetti; Detlef Lohse

    2006-01-01

    Self-similarity has been the paradigmatic picture for the pinch-off of a drop. Here we will show through high-speed imaging and boundary integral simulations that the inverse problem, the pinch-off of an air bubble in water, does not obey self-similarity (of the first kind): A disk is quickly pulled through a water surface, leading to a giant, cylindrical void, which at

  1. Hot giant loop holography

    SciTech Connect

    Grignani, Gianluca [Dipartimento di Fisica, Universita di Perugia, INFN Sezione di Perugia, Via A. Pascoli, 06123 Perugia (Italy); Karczmarek, Joanna L.; Semenoff, Gordon W. [Department of Physics and Astronomy, University of British Columbia, Vancouver, British Columbia V6T 1Z1 (Canada)

    2010-07-15

    We argue that there is a phase transition in the expectation value of the Polyakov loop operator in the large N limit of the high temperature deconfined phase of N=4 Yang-Mills theory on a spatial S{sup 3}. It occurs for the large completely symmetric representation of the SU(N) symmetry group. We speculate that this transition is reflected in the D-branes which are the string theory duals of giant loops.

  2. A giant graviton genealogy

    E-print Network

    Lozano, Yolanda; Prinsloo, Andrea

    2013-01-01

    In this article we extend the construction of giant gravitons from holomorphic surfaces [arXiv:hep-th/0010206] to the ABJM correspondence. We construct a new class of 1/6-BPS M5-branes wrapping 5-manifolds in S^7/Z_k and supported by a large angular momentum in the orbifold space. These orbifold giant gravitons undergo a supersymmetry enhancement to 1/3-BPS and 1/2-BPS configurations in special cases. The compactification of M-theory on AdS_4 x S^7/Z_k to type IIA superstring theory on AdS_4 x CP^3 then gives rise to another new class of 1/6-BPS D4 and NS5-branes wrapping 4 and 5-manifolds in CP^3. The D4-branes carry a combination of D0-brane charge and angular momentum in the complex projective space, while the NS5-branes are supported only by D0-brane charge. Finally, we present a detailed analysis of a one-parameter family of 1/2-BPS M5-brane orbifold giant gravitons, and their D4 and NS5-brane CP^3 descendants.

  3. A giant graviton genealogy

    E-print Network

    Yolanda Lozano; Jeff Murugan; Andrea Prinsloo

    2013-06-19

    In this article we extend the construction of giant gravitons from holomorphic surfaces [arXiv:hep-th/0010206] to the ABJM correspondence. We construct a new class of 1/6-BPS M5-branes wrapping 5-manifolds in S^7/Z_k and supported by a large angular momentum in the orbifold space. These orbifold giant gravitons undergo a supersymmetry enhancement to 1/3-BPS and 1/2-BPS configurations in special cases. The compactification of M-theory on AdS_4 x S^7/Z_k to type IIA superstring theory on AdS_4 x CP^3 then gives rise to another new class of 1/6-BPS D4 and NS5-branes wrapping 4 and 5-manifolds in CP^3. The D4-branes carry a combination of D0-brane charge and angular momentum in the complex projective space, while the NS5-branes are supported only by D0-brane charge. Finally, we present a detailed analysis of a one-parameter family of 1/2-BPS M5-brane orbifold giant gravitons, and their D4 and NS5-brane CP^3 descendants.

  4. Nucleosynthesis in red giant stars

    NASA Astrophysics Data System (ADS)

    Mowlavi, Nami

    The production of elements from helium-3 to fluorine in low- and intermediate-mass stars is reviewed and compared to chemical abundances observed at the surface of both red giant branch and asymptotic giant branch stars. It is highlighted that, while the trends predicted by standard models are generally well confirmed, many chemical abundances observed at the surface of red giants require the operation of non-standard mixing in the stellar interior. In addition, chemical abundance predictions from presently available asymptotic giant branch models further suffer from the uncertainties affecting the third dredge-up phenomenon, the source of neutrons and the hot bottom burning process.

  5. Giant European dinosaur found in Spain

    NSDL National Science Digital Library

    American Association for the Advancement of Science (AAAS; )

    2006-12-21

    Fossils of a giant Sauropod, found in Spain, reveal that Europe was home to giant dinosaurs in the Late Jurassic period -- about 150 million years ago. Giant dinosaurs have previously been found mainly in the New World and Africa.

  6. Genetics Home Reference: Giant axonal neuropathy

    MedlinePLUS

    ... literature OMIM Genetic disorder catalog Conditions > Giant axonal neuropathy On this page: Description Genetic changes Inheritance Diagnosis ... definitions Reviewed October 2007 What is giant axonal neuropathy? Giant axonal neuropathy is an inherited condition involving ...

  7. Gene expression analysis reveals marked differences in the transcriptome of infantile hemangioma endothelial cells compared to normal dermal microvascular endothelial cells

    PubMed Central

    2013-01-01

    Background Infantile hemangiomas are benign vascular tumors primarily found on the skin in 10% of the pediatric population. The etiology of this disease is largely unknown and while large scale genomic studies have examined the transcriptomes of infantile hemangioma tumors as a whole, no study to date has compared the global gene expression profiles of pure infantile hemangioma endothelial cells (HEMECs) to that of normal human dermal microvascular endothelial cells (HDMVECs). Methods To shed light on the molecular differences between these normal and aberrant dermal endothelial cell types, we performed whole genome microarray analysis on purified cultures of HEMECs and HDMVECs. We then utilized qPCR and immunohistochemistry to confirm our microarray results. Results Our array analysis identified 125 genes whose expression was upregulated and 104 genes whose expression was downregulated by greater than two fold in HEMECs compared to HDMVECs. Bioinformatics analysis revealed three major classifications of gene functions that were altered in HEMECs including cell adhesion, cell cycle, and arachidonic acid production. Several of these genes have been reported to be critical regulators and/or mutated in cancer, vascular tumors, and vascular malformations. We confirmed the expression of a subset of these differentially expressed genes (ANGPT2, ANTXR1, SMARCE1, RGS5, CTAG2, LTBP2, CLDN11, and KISS1) using qPCR and utilized immunohistochemistry on a panel of paraffin embedded infantile hemangioma tumor tissues to demonstrate that the cancer/testis antigen CTAG2 is highly abundant in vessel-dense proliferating infantile hemangiomas and with significantly reduced levels during tumor involution as vascular density decreases. Conclusion Our data reveal that the transcriptome of HEMECs is reflective of a pro-proliferative cell type with altered adhesive characteristics. Moveover, HEMECs show altered expression of many genes that are important in the progression and prognosis of metastatic cancers. PMID:23531100

  8. IntrAst1 (Petrovay) Giant Planets THE GIANT PLANETS

    E-print Network

    Petrovay, Kristóf

    (Petrovay) Giant Planets Differential rotation (a.k.a. zonal flows) Caused by: convective flows + Coriolis belts: late heavy bombardment ("Lunar cataclism") #12;IntrAst1 (Petrovay) Giant Planets RINGS THE RINGS Planets Origin of sharp edges / thin rings: shepherd satellites. E.g. A sharp oter edge of A ring -- Atlas

  9. Chemoembolization of hepatic malignancy

    Microsoft Academic Search

    Carin F. Gonsalves; Daniel B. Brown

    2009-01-01

    Treatment of primary and secondary hepatic malignancies with transarterial chemoembolization represents an essential component\\u000a of interventional oncology. This article discusses patient selection, procedure technique, results, and complications associated\\u000a with transarterial chemoembolization.

  10. Chemoembolization of hepatic malignancy

    Microsoft Academic Search

    Carin F. Gonsalves; Daniel B. Brown

    Treatment of primary and secondary hepatic malignancies with transarterial chemoembolization (TACE) represents an essential\\u000a component of interventional oncology. This article discusses patient selection, procedure technique, results, and complications\\u000a associated with TACE.

  11. Hepatitis C: Mental Health

    MedlinePLUS

    ... a headache or other physical problem. Taking some deep breaths also releases tension. Coping tips It is completely normal to have an emotional reaction upon learning that you have hepatitis C, such as anxiety, ...

  12. Drug-induced hepatitis

    MedlinePLUS

    ... induced hepatitis. Painkillers and fever reducers that contain acetaminophen are a common cause of liver inflammation. These ... problem. However, if you took high doses of acetaminophen , treatment should be started as soon as possible ...

  13. Hepatitis Risk Assessment

    MedlinePLUS

    ... About the Division of Viral Hepatitis Contact Us File Formats Help: How do I view different file formats (PDF, DOC, PPT, MPEG) on this site? Adobe PDF file Microsoft PowerPoint file Microsoft Word file Microsoft Excel ...

  14. Viral Hepatitis: A through E and Beyond

    MedlinePLUS

    ... travelers How can hepatitis B be prevented? The hepatitis B vaccine offers the best protection. All infants and unvaccinated ... should receive hepatitis B immune globulin and the hepatitis B vaccine within 12 hours of birth to help prevent ...

  15. Hepatitis A Also Known As Hep A

    MedlinePLUS

    ... 2013 Hepatitis A Hepatitis A is a contagious viral infection that can easily affect children and adults. It is one of the most common types of hepatitis virus. Often when you hear about hepatitis A it ...

  16. Impact of image guided fine needle aspiration cytology in diagnosis of pediatric hepatic mass and cytohistologic concordance

    PubMed Central

    Das, Chhanda; Mukhopadhyay, Madhumita; Sengupta, Moumita; Saha, Ashis Kumar; Mukhopadhyay, Biswanath

    2014-01-01

    Background: Pediatric hepatic mass is a heterogeneous group of benign and malignant lesions. Percutaneous fine needle aspiration cytology (FNAC) can be utilized as a diagnostic modality to assess the nature of radiologically demonstrated hepatic lesions and thus facilitate individualized treatment. Aims and Objective: The objective of the present study was to determine the diagnostic accuracy of percutaneous FNAC of pediatric liver masses, a procedure that is less invasive than open biopsy. Materials and Methods: A prospective, observational study was carried out in the Department of Pathology in collaboration with Department of Pediatric surgery and Radio-diagnosis including 31 pediatric patients presenting over last two years (June 2011 to May 2013) with focal hepatic lesion on ultrasound and computed tomography (CT) scan. FNAC was carried out under image guidance and cytodiagnosis was reached after appropriate staining. By comparing with histopathology reports, diagnostic accuracy of cytology was evaluated. Result: Among 31 cases included in the study, 51.6% cases were cytologically benign and hemangioma was the most common benign lesion. Hepatoblastoma was the most accounted malignant tumour (12.9%). FNAC provided 94% sensitivity and 92% specificity in diagnosing benign and malignant tumours. Overall diagnostic accuracy was 93.10%. No significant complication was noted. Conclusion: Percutaneous FNAC under image guidance is an effective diagnostic tool for diagnosis of primary and metastatic tumours of liver in pediatric patients. PMID:24741212

  17. Hepatitis b vaccination

    Microsoft Academic Search

    Albert D. Min; Aaron Walfish; Henry C. Bodenheimer

    2006-01-01

    Hepatitis B virus (HBV)infection is a major cause of chronic hepatitis and cirrhosis,with an estimated 350 million people\\u000a worldwide infected with the virus.Despite continuing advances in antiviral therapy,a cure for chronic HBV infection is considered\\u000a an elusive goal.Thus,primary prevention by immunization with HBV vaccines remains the most effective means to control the\\u000a transmission of HBV infection.

  18. Torsed pedunculated hepatic hamartoma

    Microsoft Academic Search

    Ignacio Vázquez-Lima; José L. Vázquez; Marta Gallego; Rebeca Fernández; Pilar Fernández

    2009-01-01

    We report a 9-year-old boy with a 6-h history of acute abdominal pain due to torsion of a pedunculated hepatic mesenchymal\\u000a hamartoma. The lesion was seen, on US and CT, to connect to the liver through a pedicle. Mesenchymal hepatic hamartomas are\\u000a unusual tumours that may be pedunculated, and this is a unique case complicated by torsion. The radiological and

  19. Foetal hepatic calcification

    Microsoft Academic Search

    N. D. Hawass; M. G. El Badawi; J. A. Fatani; A. Al-Meshari; D. Makanjoula; Y. B. Edress

    1990-01-01

    Thirty-three cases of 1,500 spontaneously-aborted foetuses showed hepatic calcifications. The exact location of these calcifications were confirmed by contrast studies, anatomic dissection, and further histology when necessary. Of them, 18 were calcified hepatic vein thrombi (CHVT), 12 were calcified portal vein thrombi (CPVT), 2 were parenchymal calcifications, and one was mixed. Associated anomalies were high (85% of cases). No significant

  20. Solitary Hepatic Lymphangioma

    PubMed Central

    Stavropoulos, M.; Vagianos, C.; Scopa, C. D.; Dragotis, C.; Androulakis, J.

    1994-01-01

    Hepatic lymphangiomas are extremely rare; moreover cystic lymphangiomas usually arise in areas such as the neck and axilla, where loose connective tissue allows the expansion of lymphatic channels. The case of a 65-year old male is described, who presented with a solitary lymphangioma in the liver. The lesion was discovered incidentally and due to diagnostic uncertainty was removed surgically. A short review of histology, clinical presentation and preoperative diagnostic difficulties of hepatic lymphangiomas is given. PMID:7993862

  1. Giant Cell Arteritis

    Microsoft Academic Search

    Aki Kawasaki

    ? Giant cell arteritis (GCA) is the most common vasculitis in Caucasian adults older than 50 years. \\u000a \\u000a ? There are three predominant clinical subtypes of GCA: systemic inflammatory syndrome, cranial arteritis, and largevessel\\u000a vasculitis. ? Patients with large-vessel vasculitis are likely to have negative temporal artery biopsy results; thus, diagnosis\\u000a rests on clinical suspicion, corroborative laboratory tests, and imaging. \\u000a \\u000a \\u000a \\u000a ?

  2. Multifrequency 'giant' photopleochroism

    Microsoft Academic Search

    G. A. Medvedkin; Iu. V. Rud; M. A. Tairov

    1988-01-01

    An experimental observation of multifrequency 'giant' photopleochroism in polarimetric diode structures based on II-IV-V(2) crystals with a chalcopyrite lattice (e.g., CdO\\/Al2O3\\/CdSnP2) is reported. The fabrication of the structures and details of the experimental procedure are briefly discussed, and a typical spectrum of the photopleochroism coefficient of the CdO\\/Al2O3\\/CdSnP2 structure, calculated for spectral photoresponse measurements at 300 K, is shown. The

  3. A Giant Hemorrhagic Adrenal Pseudocyst

    Microsoft Academic Search

    Goran Stimac; Josip Katusic; Mario Sucic; Mario Ledinsky; Bozo Kruslin; Davor Trnski

    2008-01-01

    Objective: To report a rare case of a giant hemorrhagic adrenal pseudocyst and highlight the importance of this entity to clinicians. Case Presentation: A 57-year-old woman presented with a 1-year history of abdominal pain and distension. Ultrasonography and multislice computed tomography revealed a giant cystic (partially solid) mass over the left suprarenal region measuring 20 × 17 × 15 cm.

  4. Mechanisms of Hepatic Fibrogenesis

    PubMed Central

    Friedman, Scott L.

    2010-01-01

    Substantial improvements in the treatment of chronic liver disease have accelerated interest in uncovering the mechanisms underlying hepatic fibrosis and its resolution. Activation of resident hepatic stellate cells into proliferative, contractile, and fibrogenic cells in liver injury remains a dominant theme driving the field. However, several new areas of rapid progress in the past 5–10 years also have taken root, including: (1) identification of different fibrogenic populations apart from resident stellate cells, for example, portal fibroblasts, fibrocytes, and bone-marrow– derived cells, as well as cells derived from epithelial mesenchymal transition; (2) emergence of stellate cells as finely regulated determinants of hepatic inflammation and immunity; (3) elucidation of multiple pathways controlling gene expression during stellate cell activation including transcriptional, post-transcriptional, and epigenetic mechanisms; (4) recognition of disease-specific pathways of fibrogenesis; (5) re-emergence of hepatic macrophages as determinants of matrix degradation in fibrosis resolution and the importance of matrix cross-linking and scar maturation in determining reversibility; and (6) hints that hepatic stellate cells may contribute to hepatic stem cell behavior, cancer, and regeneration. Clinical and translational implications of these advances have become clear, and have begun to impact significantly on the management and outlook of patients with chronic liver disease. PMID:18471545

  5. Immigration and viral hepatitis.

    PubMed

    Sharma, Suraj; Carballo, Manuel; Feld, Jordan J; Janssen, Harry L A

    2015-08-01

    WHO estimates reveal that the global prevalence of viral hepatitis may be as high as 500million, with an annual mortality rate of up to 1.3million individuals. The majority of this global burden of disease is borne by nations of the developing world with high rates of vertical and iatrogenic transmission of HBV and HCV, as well as poor access to healthcare. In 2013, 3.2% of the global population (231million individuals) migrated into a new host nation. Migrants predominantly originate from the developing countries of the south, into the developed economies of North America and Western Europe. This mass migration of individuals from areas of high-prevalence of viral hepatitis poses a unique challenge to the healthcare systems of the host nations. Due to a lack of universal standards for screening, vaccination and treatment of viral hepatitis, the burden of chronic liver disease and hepatocellular carcinoma continues to increase among migrant populations globally. Efforts to increase case identification and treatment among migrants have largely been limited to small outreach programs in urban centers, such that the majority of migrants with viral hepatitis continue to remain unaware of their infection. This review summarizes the data on prevalence of viral hepatitis and burden of chronic liver disease among migrants, current standards for screening and treatment of immigrants and refugees, and efforts to improve the identification and treatment of viral hepatitis among migrants. PMID:25962882

  6. Giant omphaloceles with a small abdominal defect: prenatal diagnosis and neonatal management.

    PubMed

    Pelizzo, G; Maso, G; Dell'Oste, C; D'Ottavio, G; Bussani, R; Uxa, F; Conoscenti, G; Schleef, J

    2005-12-01

    A giant omphalocele is a liver-containing protrusion through an abdominal defect wider than 5 cm in diameter. The giant form with a small abdominal wall defect is a rare condition which, to our knowledge, has not been described previously. We describe three cases with the typical features of elongated vascular liver pedicle and angiomatosis of the hepatic portal system. The abnormal liver organogenesis, due to extra-abdominal development, represented a significant risk factor for hepatic thrombosis after visceral reduction and liver rotation. All the neonates underwent surgery on the first day of postnatal life. One died because of a postoperative liver infarction, and the survivors needed prolonged respiratory support. Prenatal sonographic features, timing, delivery, type of surgical repair, and postnatal outcome are reviewed. A prenatal sonographic diagnosis could be useful to evaluate the abdominal ring and serial ultrasound examinations are recommended to detect promptly ominous signs of hepatic and bowel damage. Color Doppler may be useful to assess the anatomy of the abdominal vessels and their relationships with the herniated organs, although it was not used in any of the cases reported here. This congenital malformation might be considered as a pathological entity separate from giant omphalocele with large abdominal defect, with a severe prognosis due possibly to its different embryological development. PMID:16308903

  7. Giant malignant insulinoma

    PubMed Central

    Karavias, Dimitrios; Habeos, Ioannis; Maroulis, Ioannis; Kalogeropoulou, Christina; Tsamandas, Athanasios; Chaveles, Ioannis

    2015-01-01

    Insulinomas are the most common pancreatic neuroendocrine tumors. Most insulinomas are benign, small, intrapancreatic solid tumors and only large tumors have a tendency for malignancy. Most patients present with symptoms of hypoglycemia that are relieved with the administration of glucose. We herein present the case of a 75-year-old woman who presented with an acute hypoglycemic episode. Subsequent laboratory and radiological studies established the diagnosis of a 17-cm malignant insulinoma, with local invasion to the left kidney, lymph node metastasis, and hepatic metastases. Patient symptoms, diagnostic and imaging work-up and surgical management of both the primary and the metastatic disease are reviewed. PMID:25960993

  8. Giant malignant insulinoma.

    PubMed

    Karavias, Dimitrios; Habeos, Ioannis; Maroulis, Ioannis; Kalogeropoulou, Christina; Tsamandas, Athanasios; Chaveles, Ioannis; Karavias, Dionissios

    2015-05-01

    Insulinomas are the most common pancreatic neuroendocrine tumors. Most insulinomas are benign, small, intrapancreatic solid tumors and only large tumors have a tendency for malignancy. Most patients present with symptoms of hypoglycemia that are relieved with the administration of glucose. We herein present the case of a 75-year-old woman who presented with an acute hypoglycemic episode. Subsequent laboratory and radiological studies established the diagnosis of a 17-cm malignant insulinoma, with local invasion to the left kidney, lymph node metastasis, and hepatic metastases. Patient symptoms, diagnostic and imaging work-up and surgical management of both the primary and the metastatic disease are reviewed. PMID:25960993

  9. Giant solitary trichoepithelioma.

    PubMed

    Teli, Bhavuray; Thrishuli, P B; Santhosh, R; Amar, D N; Rajpurohit, Shravan

    2015-01-01

    Adnexal tumors like giant solitary trichoepitheliomas are uncommon to most of us to permit a ready familiarity with them. Information regarding the genesis, clinical profile, behavior, and management options for this tumor is limited. There are 18 cases reported in the world literature till date. This review attempts to provide insight to this rare tumor. Our search included indexed literature from Pubmed, Directory of Open Access Journals, Health Inter Network Access to Research Initiative and Google databases in addition to standard dermatology texts. Giant solitary trichoepithelioma is a rare trichogenic tumor with potential for local recurrence. It has predilection for the older age, but may present at any age including at birth. It has close resemblance to basal cell carcinoma and other skin adnexal tumors - clinically, cytologically, and histologically. CD10, CD 34, PHLDA1 but not p75NTR are useful adjunct markers. Surgical excision is the standard treatment. Recurrence and possible transformation into BCC cautions follow up at regular intervals. PMID:25839021

  10. [Giant pleural fibroma].

    PubMed

    San Feliciano Martín, L; Fernández Alvarez, D; Muriel Ramos, M; Hernández Alberca, A; Varela Simó, G

    2003-06-01

    Solitary fibrous tumors of the pleura are uncommon mesenchymal tumors that have been reported in adults. There are very few cases in children. These tumors are considered benign but their behavior is often unpredictable because they can invade nearby structures and transform into malignant variants after several years. Their clinical presentation is diverse but generally asymptomatic and they are detected incidentally in routine radiologic studies. Prognosis depends firstly on resectability of the tumour and secondly on its size, mitotic count, polymorphism, and necrosis within the tumour. Surgical resection is usually curative. Long-term follow-up is recommended because local recurrences can occur after surgery. We report the case of an asymptomatic 15-year-old girl with a giant thoracic mass revealed incidentally on a chest radiograph. Physical examination revealed thoracic asymmetry and no sounds of breathing were found in the right lung. Computerized tomography and magnetic resonance images showed the giant size of the mass. Preoperative fine needle biopsy was performed. Intraoperative biopsy confirmed the diagnosis. Although histologically benign, the tumors may enlarge rapidly. In the present case, because of the localization and size of the tumor, the patient was at increased risk. The tumour was resected and the postoperative course was uneventful. At present our patient remains under long term annual follow-up. PMID:12781119

  11. Comparison of outcomes between overlapping-spot and single-spot photodynamic therapy for circumscribed choroidal hemangioma

    PubMed Central

    Su, Zhao-An; Tang, Xia-Jing; Zhang, Li-Xia; Su, Xiao-Hong

    2014-01-01

    AIM To compare the efficacy and safety of photodynamic therapy (PDT) with overlapping multiple spots and single spot for treating circumscribed choroidal hemangioma. METHODS Twenty-two patients (22 eyes) with symptomatic circumscribed choroidal hemangioma received PDT treatment. Fourteen patients received overlapping spots (two to three spots) PDT, whereas eight patients received single-spot PDT. Laser was used at 50J/cm2 for 83s in the overlapping-spot group and 50J/cm2 for 166s in the single-spot group. Clinical examination, funduscopy, fluorescein angiography, and ultrasonography were performed at baseline and after treatment. RESULTS The mean follow-up time was 28.5±8.0 months in the overlapping-spot group and 27.0±5.0 months in the single-spot group. Nine patients (64.2%) had their vision improved over two lines on the Snellen chart, and five patients showed stable visual acuity in the overlapping-spot group. The mean thickness of tumor decreased from 2.7±0.8mm to 1.2±0.9mm, and the mean greatest tumor linear dimension decreased from 7.4±1.5mm to 4.5±3.5mm after treatment. In the single-spot group, two patients (25%) had their vision improved over two lines on the Snellen chart, and six patients had unchanged stable vision. The mean tumor thickness in this group decreased from 2.5±0.7mm to 1.4±1.0mm, and the mean greatest tumor linear dimension decreased from 7.2±1.3mm to 4.7±3.6mm. No significant differences in visual improvement and tumor regression were found between the two groups. CONCLUSION Overlapping-spot PDT under appropriate treatment parameters and strategies is as effective and safe as single-spot PDT for treating symptomatic circumscribed choroidal hemangioma. Improved or stabilized visual acuity was achieved as a result of tumor regression. PMID:24634866

  12. Added value of Gd-EOB-DTPA-enhanced Hepatobiliary phase MR imaging in evaluation of focal solid hepatic lesions

    PubMed Central

    2013-01-01

    Background Correct characterization of focal solid hepatic lesions has always been a challenge and is of great diagnostic and therapeutic relevance. The purpose of this study was to determine the added value of hepatobiliary phase images in Gd-EOB-DTPA-enhanced magnetic resonance imaging (MRI) for differentiating focal solid hepatic lesions. Methods In this retrospective trial 84 consecutive patients underwent Gd-EOB-DTPA-enhanced MR examinations. MRI was conducted for 64 patients with malignant focal hepatic lesions (34 hepatocellular carcinoma (HCC), 30 metastases) and for 20 patients with benign hepatic lesions (14 focal nodular hyperplasia (FNH), 3 adenoma, 3 hemangioma). Five radiologists independently reviewed three sets of MR images by means of a 5-point confidence scale from score 1 (definitely benign) to score 5 (definitely malignant): set 1: unenhanced images; set 2: unenhanced and Gd-EOB-DTPA-enhanced dynamic images; set 3: hepatobiliary phase images in addition to set 2. Accuracy was assessed by the alternative free-response receiver operating characteristic curve (Az) and the index of diagnostic performance was calculated. Results Diagnostic accuracy was significantly improved by the addition of Gd-EOB-DTPA-enhanced dynamic images: Az in set 1 was 0.708 and 0.833 in set 2 (P?=?0.0002). The addition of hepatobiliary phase images increased the Az value to 0.941 in set 3 (set 3 vs set 2, P?hepatic lesions. PMID:24289722

  13. Diffuse choroidal hemangioma associated with exudative retinal detachment in a Sturge-Weber syndrome case: photodynamic therapy and intravitreous bevacizumab.

    PubMed

    Anaya-Pava, Edwin J; Saenz-Bocanegra, Carlos H; Flores-Trejo, Alejandro; Castro-Santana, Norma A

    2015-03-01

    We report the case of a young female patient with a diffuse choroidal hemangioma (DCH) and glaucoma as part of Sturge-Weber syndrome (SWS) and symptomatic retinal detachment that was treated successfully with photodynamic therapy (PDT) and intravitreal bevacizumab (IVB). The patient was treated with a single session of PDT, a 689-nm laser was used to deliver 50J/cm(2) with a maximum spot size of 6400?m, for 166s. IVB was administered 3 days later. The exudative retinal detachment (ERD), macular edema and visual acuity improved one week after treatment. The patient was followed for 18 months with no recurrence of ERD, and her visual acuity was preserved. PDT followed by IVB may be an effective treatment option for visual deterioration due to ERD in patients with DCHs, as are found in SWS. PMID:25560419

  14. Hepatic manifestations during amoebic dysentery

    Microsoft Academic Search

    S. Ramachandran; C. N. A. Rajapakse; R. de Saram; S. Sivalingam

    1973-01-01

    A variety of hepatic manifestations may occur during attacks of acute amoebic dysentery, conforming to clearly defined clinical groups.The incidence of definite hepatic involvement presenting as cases of hepatic amoebiasis with or without demonstrable pus or with tender hepatomegaly was 57·5%.While it is possible that the cases presenting with hepatic manifestations without demonstrable pus are due to small deep-seated abscesses,

  15. Hepatitis B virus infection.

    PubMed

    Trépo, Christian; Chan, Henry L Y; Lok, Anna

    2014-12-01

    Hepatitis B virus infection is a major public health problem worldwide; roughly 30% of the world's population show serological evidence of current or past infection. Hepatitis B virus is a partly double-stranded DNA virus with several serological markers: HBsAg and anti-HBs, HBeAg and anti-HBe, and anti-HBc IgM and IgG. It is transmitted through contact with infected blood and semen. A safe and effective vaccine has been available since 1981, and, although variable, the implementation of universal vaccination in infants has resulted in a sharp decline in prevalence. Hepatitis B virus is not cytopathic; both liver damage and viral control--and therefore clinical outcome--depend on the complex interplay between virus replication and host immune response. Overall, as much as 40% of men and 15% of women with perinatally acquired hepatitis B virus infection will die of liver cirrhosis or hepatocellular carcinoma. In addition to decreasing hepatic inflammation, long-term antiviral treatment can reverse cirrhosis and reduce hepatocellular carcinoma. Development of new therapies that can improve HBsAg clearance and virological cure is warranted. PMID:24954675

  16. Elastolytic Actinic Giant Cell Granuloma.

    PubMed

    Gutiérrez-González, Enrique; Pereiro, Manuel; Toribio, Jaime

    2015-07-01

    Actinic granuloma and annular elastolytic giant cell granuloma are different terms used to define skin lesions characterized by elastolysis, elastophagocytosis, and multinucleated giant cell infiltrate. The clinical appearance varies from papules to annular plaques. Although elastolytic actinic giant cell granuloma shares some clinical features with granuloma annulare, they can be differentiated by histopathologic findings. The disease is initiated by an immune response triggered by different factors that alter the elastic tissue. The course tends to be chronic, with variable response to treatments, although spontaneous remission may occur. Diabetes mellitus is the systemic disease most frequently associated with this condition. PMID:26143417

  17. Retroperitoneal giant ancient schwannoma.

    PubMed

    Khandakar, Binny; Dey, Soumit; Chandra Paul, Prabir; Medda, Sriparna; Bhattacharya, Aparna; Datta, Saikat

    2014-12-01

    Ancient schwannoma is a rare variant of benign peripheral nerve sheath tumor, often morphologically mimicking malignancy. Retroperitoneum is an uncommon location. We describe one case of giant retroperitoneal ancient schwannoma. Literature concerning this variant is also reviewed. A 65 year old male presented with altered bowel habits. Imaging findings revealed a large heterogeneous mass in the retroperitoneum. The patient was treated with complete excision. Grossly, the tumor was predominantly solid with focal cystic degeneration. Histological examination showed an encapsulated spindle cell tumor with nuclear palisading, very focal nuclear atypia and widespread foam cell infiltration - findings consistent with ancient schwannoma. A diagnosis of ancient schwannoma can be considered for a solid-cystic encapsulated mass in the retroperitoneum. Malignant transformation is very rare. Local recurrence is uncommon following complete excision. The authors have nothing to disclose. PMID:25481325

  18. 6 Immunopathogenesis of viral hepatitis

    Microsoft Academic Search

    Barbara Rehermann

    1996-01-01

    More than 500 million people world-wide suffer from viral hepatitis which can be caused by a variety of distinct infectious agents. The spectrum of disease, which ranges from acute self-limited hepatitis to liver cirrhosis, not only reflects the different biological properties and pathogenicity of the hepatitis viruses, but is also the result of the specific interaction between each virus and

  19. Viral hepatitis in the Arctic

    Microsoft Academic Search

    Brian J McMahon

    Objectives. Summarize research on viral hepatitis in indigenous populations in the Arctic. Study De- sign. Literature review. Methods. Medline search from 1966-2003. Results. High prevalence rates of total hepatitis A antibody of > 50% and of hepatitis B of between 22% in Alaska and 42% in Greenland for total infection and between 3% in Canada and 12% in Siberia for

  20. Atmospheres of Extrasolar Giant Planets

    E-print Network

    Mark S. Marley; Jonathan Fortney; Sara Seager; Travis Barman

    2006-02-21

    The key to understanding an extrasolar giant planet's spectrum--and hence its detectability and evolution--lies with its atmosphere. Now that direct observations of thermal emission from extrasolar giant planets are in hand, atmosphere models can be used to constrain atmospheric composition, thermal structure, and ultimately the formation and evolution of detected planets. We review the important physical processes that influence the atmospheric structure and evolution of extrasolar giant planets and consider what has already been learned from the first generation of observations and modeling. We pay particular attention to the roles of cloud structure, metallicity, and atmospheric chemistry in affecting detectable properties through Spitzer Space Telescope observations of the transiting giant planets. Our review stresses the uncertainties that ultimately limit our ability to interpret EGP observations. Finally we will conclude with a look to the future as characterization of multiple individual planets in a single stellar system leads to the study of comparative planetary architectures.

  1. Atmospheres of Extrasolar Giant Planets

    NASA Technical Reports Server (NTRS)

    Marley, Mark

    2006-01-01

    The next decade will almost certainly see the direct imaging of extrasolar giant planets around nearby stars. Unlike purely radial velocity detections, direct imaging will open the door to characterizing the atmosphere and interiors of extrasola planets and ultimately provide clues on their formation and evolution through time. This process has already begun for the transiting planets, placing new constraints on their atmospheric structure, composition, and evolution. Indeed the key to understanding giant planet detectability, interpreting spectra, and constraining effective temperature and hence evolution-is the atmosphere. I will review the universe of extrasolar giant planet models, focusing on what we have already learned from modeling and what we will likely be able to learn from the first generation of direct detection data. In addition to these theoretical considerations, I will review the observations and interpretation of the - transiting hot Jupiters. These objects provide a test of our ability to model exotic atmospheres and challenge our current understanding of giant planet evolution.

  2. 72 FR 44560 - Guidance for Industry: Adequate and Appropriate Donor Screening Tests for Hepatitis B; Hepatitis...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2007-08-08

    ...Adequate and Appropriate Donor Screening Tests for Hepatitis B; Hepatitis B Surface Antigen Assays Used to Test Donors of Whole...Adequate and Appropriate Donor Screening Tests for Hepatitis B; Hepatitis B Surface Antigen (HBsAg)...

  3. Cutaneous manifestations of viral hepatitis.

    PubMed

    Akhter, Ahmed; Said, Adnan

    2015-02-01

    There are several extrahepatic cutaneous manifestations associated with hepatitis B and hepatitis C virus infection. Serum sickness and polyarteritis nodosa are predominantly associated with hepatitis B infection, whereas mixed cryoglobulinemia associated vasculitis and porphyria cutanea tarda are more frequently seen in hepatitis C infection. The clinico-pathogenic associations of these skin conditions are not completely defined but appear to involve activation of the host immune system including the complement system. Management of the aforementioned cutaneous manifestations of viral hepatitis is often similar to that done in cases without viral hepatitis, with control of immune activation being a key strategy. In cases associated with hepatitis B and C, control of viral replication with specific antiviral therapy is also important and associated with improvement in most of the associated clinical manifestations. PMID:25809574

  4. NK cells in chronic hepatitis C and hepatitis B Fine Characterization of Intra-hepatic NK cells Expressing

    E-print Network

    Boyer, Edmond

    1 NK cells in chronic hepatitis C and hepatitis B Fine Characterization of Intra-hepatic NK cells Expressing Natural Killer Receptors in Chronic Hepatitis B and C Paula Bonorino1,2* , Muhammad Ramzan 1. The proportions of intra-hepatic NK cells expressing either NKG2A, and/or CD158a,h, CD158b,j differed

  5. P. Roingeard -Journal of Viral Hepatitis 2013 ; 20, 77-84. Page 1 Hepatitis C virus diversity and hepatic steatosis

    E-print Network

    Paris-Sud XI, Université de

    P. Roingeard - Journal of Viral Hepatitis 2013 ; 20, 77-84. Page 1 REVIEW Hepatitis C virus diversity and hepatic steatosis P. Roingeard. INSERM U966, Université François Rabelais & CHRU de Tours, 10, published in "Journal of Viral Hepatitis 2013;20(2):77-84" #12;P. Roingeard - Journal of Viral Hepatitis

  6. Hepatic siderosis in alcoholics

    Microsoft Academic Search

    Andrew W. Jakobovits; Marsha Y. Morgan; Sheila Sherlock

    1979-01-01

    In a population of 157 (120 males, 37 females) predominantly British alcoholics with liver disease, the incidence of some degree of hepatic siderosis, as estimated by stainable parenchymal iron, was 57.3%. The incidence of significant siderosis (grades III and IV) was 7%, and was similar for both sexes. In the female alcoholics there was a significant correlation between age and

  7. Viral hepatitis in Bucharest.

    PubMed Central

    Paquet, C.; Babes, V. T.; Drucker, J.; Sénémaud, B.; Dobrescu, A.

    1993-01-01

    A seroprevalence survey of viral hepatitis was conducted in Bucharest, Romania, between April and July 1990 on a systematic sample of 1355 persons drawn from the general population and groups at higher risk of infection. Sera were tested for hepatitis A, B, and C (HAV, HBV and HCV, resp.) markers using an enzyme-linked immunosorbent assay (ELISA) method. The prevalences of HAV and HBV markers were high in all groups. A total of 47% of the adults from the general population and 39.8% of the children aged 0-16 years had at least one HBV marker. Of the pregnant women 7.8% were positive for hepatitis B surface antigen. Among infants (0-3 years of age) living in orphanages, the prevalence of at least one HBV marker was 54.6%. The findings also confirmed that HCV was circulating in Romania. The results are consistent with national surveillance data and confirm that viral hepatitis is a major public health problem in Romania. Preventive measures will have to include HBV immunization of infants, with an appropriately targeted immunization strategy being determined through further epidemiological studies. PMID:8313496

  8. Hepatitis (For Parents)

    MedlinePLUS

    ... have time to get any necessary immunizations. The HBV vaccine is given to both children and adults as ... cause the kind of response needed for a vaccine to be ... its own. Chronic hepatitis B can sometimes be treated using medications. Several drugs ...

  9. Foetal hepatic calcification.

    PubMed

    Hawass, N D; el Badawi, M G; Fatani, J A; al-Meshari, A; Makanjoula, D; Edress, Y B

    1990-01-01

    Thirty-three cases of 1,500 spontaneously-aborted foetuses showed hepatic calcifications. The exact location of these calcifications were confirmed by contrast studies, anatomic dissection, and further histology when necessary. Of them, 18 were calcified hepatic vein thrombi (CHVT), 12 were calcified portal vein thrombi (CPVT), 2 were parenchymal calcifications, and one was mixed. Associated anomalies were high (85% of cases). No significant difference was found between the type and percentage of anomalies of those with CHVT and those with CPVT. The most common anomalies encountered in all cases were meconium intraluminal calcification (27%), cystic hygroma (18%), and metaphyseal defect (18%). In view of this, it is suggested that a variety of severe foetal illnesses predispose to CHVT and CPVT. At correlation with maternal factors, it was found that the highest incidence was in the third decade. A significant high percentage of mothers (33%) had been on contraceptive pills, and there was interesting inverse relationship of hepatic calcification with gravidity. Practically, it is also hoped that the awareness of the presence of various types of hepatic calcifications will help in their detection prenatally by ultrasound. PMID:2216588

  10. Viral hepatitis B

    Microsoft Academic Search

    Ching Lung Lai; Vlad Ratziu; Man-Fung Yuen; Thierry Poynard

    2003-01-01

    More than 170 million people worldwide are chronically infected with the hepatitis C virus (HCV), which is responsible for more than 100 000 cases of liver cancer per year, with similar numbers of digestive haemorrhage and ascites episodes. Major breakthroughs have been made in diagnosis and treatment, and advances in molecular biology mean that the replicative state of the virus

  11. Durchbruch bei der Therapie der Hepatitis C

    E-print Network

    Manstein, Dietmar J.

    Durchbruch bei der Therapie der Hepatitis C: Segen für die Patienten ­ Albtraum für die Behandler -Virushepatitis Oktober 2012 #12;H. Wedemeyer -Virushepatitis Oktober 2012 Hepatitisviren Hepatitis A Feinstone 1973 RNA Hepatitis B Blumberg 1965 DNA Hepatitis C Houghton 1988 RNA Hepatitis D Rizzetto 1977 RNA

  12. Giant bubble-pinchoff

    NASA Astrophysics Data System (ADS)

    Lohse, Detlef

    2006-03-01

    Self-similarity has been the paradigmatic picture for the pinch-off of a drop. Here we will show through high-speed imaging and boundary integral simulations that the inverse problem, the pinch-off of an air bubble in water, does not obey self-similarity (of the first kind): A disk is quickly pulled through a water surface, leading to a giant, cylindrical void, which at collapse creates an upward and a downward jet. The neck radius h(tau) of the void does NOT scale with the inertial power law exponent 1/2 (i.e., does not obey ``Rayleigh-scaling''). This is due to a second length-scale, the inverse curvature of the void,which follows a power-law scaling with a different exponent. Only for infinite Froude numbers the scaling exponent 1/2 is recovered. In all cases we find the void-profile to be symmetric around the minimal void radius up to the time the airflow in the neck deforms the interface.

  13. Formation of the giant planets

    NASA Technical Reports Server (NTRS)

    Lissauer, Jack J.

    2006-01-01

    The observed properties of giant planets, models of their evolution and observations of protoplanetary disks provide constraints on the formation of gas giant planets. The four largest planets in our Solar System contain considerable quantities of hydrogen and helium, which could not have condensed into solid planetesimals within the protoplanetary disk. All three (transiting) extrasolar giant planets with well determined masses and radii also must contain substantial amounts of these light gases. Jupiter and Saturn are mostly hydrogen and helium, but have larger abundances of heavier elements than does the Sun. Neptune and Uranus are primarily composed of heavier elements. HD 149026 b, which is slightly more massive than is Saturn, appears to have comparable quantities of light gases and heavy elements. HD 209458 b and TrES-1 are primarily hydrogen and helium, but may contain supersolar abundances of heavy elements. Spacecraft flybys and observations of satellite orbits provide estimates of the gravitational moments of the giant planets in our Solar System, which in turn provide information on the internal distribution of matter within Jupiter, Saturn, Uranus and Neptune. Atmospheric thermal structure and heat flow measurements constrain the interior temperatures of planets. Internal processes may cause giant planets to become more compositionally differentiated or alternatively more homogeneous; high-pressure laboratory .experiments provide data useful for modeling these processes. The preponderance of evidence supports the core nucleated gas accretion model. According to this model, giant planets begin their growth by the accumulation of small solid bodies, as do terrestrial planets. However, unlike terrestrial planets, the growing giant planet cores become massive enough that they are able to accumulate substantial amounts of gas before the protoplanetary disk dissipates. The primary questions regarding the core nucleated growth model is under what conditions planets with small cores/total heavy element abundances can accrete gaseous envelopes within the lifetimes of gaseous protoplanetary disks.

  14. Giant polarization in high polymers

    NASA Astrophysics Data System (ADS)

    Pohl, Herbert A.

    1986-07-01

    In the course of studying the properties of highly conjugated polymers we found that long range orbital delocalization conferred unexpected properties. The presence of giant electronic orbitals made these materials electroactive yet very stable. A new mode of electronic polarizability resulted, a giant nomadic polarization, making these organic polymers among the most polarizable materials ever encountered. In addition, yet other attributes could be found, such as remanent magnetization, or metallic conductivity, or unusual pressure sensitivity. The giant orbital concept opens up new vistas of materials properties. We note that one can tailor giant orbital polymers to produce pure and highly stable super-dielectrics with high dielectric constants, from 6 to 100,000. Such materials will be useful in the electric power control, as in large motor starting capacitors and in power factor correction. They will doubtless also be useful in low visibility coatings, in obscuration, in EMP shielding, in microcircuitry, in transducers, and in parametric circuits. It remains to be proven if this new molecular mode, nomadic polarization, proves superior in energy storage and loss to that of the conventional “dipole orientation” mode. Preliminary results indicate an advantage for the new giant orbital materials.

  15. Management of Covert Hepatic Encephalopathy

    PubMed Central

    Waghray, Abhijeet; Waghray, Nisheet; Mullen, Kevin

    2014-01-01

    Hepatic encephalopathy is a reversible progressive neuropsychiatric disorder that encompasses a wide clinical spectrum. Covert hepatic encephalopathy is defined as patients with minimal hepatic encephalopathy and Grade I encephalopathy by West-Haven Criteria. Terminology such as “sub-clinical”, “latent”, and “minimal” appear to trivialize the disease and have been replaced by the term covert. The lack of clinical signs means that covert hepatic encephalopathy is rarely recognized or treated outside of clinical trials with options for therapy based on patients with episodic hepatic encephalopathy. This review discusses the current available options for therapy in covert hepatic encephalopathy and focuses on non-absorbable disacharides (lactulose or lactitol), antibiotics (rifaximin), probiotics/synbiotics and l-ornithine-l-aspartate.

  16. Occult hepatitis B in Cuban HIV patients.

    PubMed

    Marité, Bello; Montalvo, María Caridad; Rodríguez, Licel de Los Ángeles; Sariego, Susel; Verdasquera, Denis; Vincent, Marguerite; Gutiérrez, Aidonis; Sánchez, Meilin

    2011-04-01

    INTRODUCTION Co-infections between hepatitis B and HIV viruses are frequent due to their similar epidemiological characteristics. Worldwide, hepatitis B infection is one of the main causes of hepatocellular carcinoma and cirrhosis. In Cuba as elsewhere, prevalences of hepatitis B and hepatitis C viral infections are higher in persons with HIV. These hepatitis viruses act as opportunistic infections in persons with HIV. In other contexts, persons with HIV have been found to be at higher risk for occult hepatitis B, defined as the presence in serum or plasma of hepatitis B virus DNA and antibodies to its core antigen, in the absence of hepatitis B surface antigen. OBJECTIVES Describe occult hepatitis B prevalence in Cuban HIV-positive patients and explore possible associations with their clinical characteristics. METHODS A total of 325 serum samples from patients positive for HIV and negative for hepatitis B surface antigen were studied, divided into two groups, Group 1, negative for hepatitis C virus; and Group 2, positive for hepatitis C virus. Exposure to hepatitis B was determined by testing for hepatitis B core antigen; samples positive for hepatitis B core antigen were then examined for presence of antibodies to hepatitis B surface antigen. Both determinations were done by ultramicroELISA. In samples positive for hepatitis B core antigen with levels of antibodies to hepatitis B surface antigen of <50 IU/L, real-time polymerase chain reaction was used to detect hepatitis B DNA and its presence examined in relation to several clinical variables. All data were obtained from patients' clinical records. RESULTS In the hepatitis-C-negative group, 27.9% (68/243) of serum samples tested were positive for hepatitis B core antigen. In the hepatitis-C-positive group, 37.8% (31/82) were positive for hepatitis B core antigen. Total hepatitis B virus exposure prevalence was 30.4% (99/325); 54.5% (54/99) showing low immunity (hepatitis B virus surface antigen <50 IU/L) and 24% of these (13/54), occult hepatitis. There was no statistically significant association between hepatitis B virus DNA and any of the clinical variables studied. CONCLUSIONS Low-immunity HIV-positive persons in our study were exposed to hepatitis B virus. Diagnosis of occult hepatitis B infection is frequent in these patients. This study suggests that diagnostic protocols for persons with HIV and without hepatitis B surface antigen should include testing for hepatitis B core antigen, with positive results followed by molecular techniques to detect occult hepatitis B. This study makes a useful contribution to prevention and control of hepatitis B in Cuba. PMID:21654589

  17. Primary hepatic sarcomas: CT findings

    Microsoft Academic Search

    Ri-Sheng Yu; Ying Chen; Biao Jiang; Liu-Hong Wang; Xiu-Fang Xu

    2008-01-01

    Primary hepatic sarcomas are rare tumors that are difficult to diagnose clinically. Different primary hepatic sarcomas may\\u000a have different clinical, morphologic, and radiological features. In this pictorial review, we summarized computed tomography\\u000a (CT) findings of some relatively common types of hepatic sarcomas, including angiosarcoma, epithelioid hemangioendothelioma\\u000a (EHE), liposarcoma, undifferentiated embryonal sarcoma (UES), leiomyosarcoma, malignant fibrous histiocytoma (MFH), and carcinosarcoma\\u000a (including

  18. Clotiazepam-induced acute hepatitis.

    PubMed

    Habersetzer, F; Larrey, D; Babany, G; Degott, C; Corbic, M; Pessayre, D; Benhamou, J P

    1989-09-01

    We report the case of a patient who developed acute hepatitis with extensive hepatocellular necrosis, 7 months after the onset of administration of clotiazepam, a thienodiazepine derivative. Clotiazepam withdrawal was followed by prompt recovery. The administration of several benzodiazepines, chemically related to clotiazepam, did not interfere with recovery and did not induce any relapse of hepatitis. This observation shows that clotiazepam can induce acute hepatitis and suggests that there is no cross hepatotoxicity between clotiazepam and several benzodiazepines. PMID:2572625

  19. Acute viral hepatitis in Hanoi, Viet Nam

    Microsoft Academic Search

    A. L. Corwin; T. C. Dai; Dao Dinh Duc; P. I. Suu; Nguyen Thu Van; Le Dang Ha; M. Janick; L. Kanti; Anni Sie; R. Soderquist; R. Graham; S. F. Wignall; K. C. Hyams

    1996-01-01

    A study of acute hepatitis was conducted in Hanoi, Viet Nam, from January 1993 to February 1995; 188 sera from clinical hepatitis cases were screened by enzyme-linked immunosorbent assay for immunoglobulin (Ig) M anti-hepatitis A virus (HAV), IgM anti-hepatitis B core antigen (HBc), IgG anti-hepatitis C virus (HCV), IgG anti-hepatitis E virus (HEV) and IgM anti-HEV. Additionally, 187 sera from

  20. Hepatitis E: current status.

    PubMed

    Pérez-Gracia, María Teresa; Mateos Lindemann, María Luísa; Caridad Montalvo Villalba, María

    2013-11-01

    Acute hepatitis E is a very common disease in developing countries, to the point that, according to World Health Organization estimates, one third of the world's population has been exposed to HEV. It also causes outbreaks in refugee camps or after natural disasters such as floods or earthquakes. Sporadic cases of acute hepatitis have been observed in practically all European countries and other developed geographical areas, not only in travelers from endemic countries but also in people with no risk factors. But, lately, new aspects of this infection are appearing in industrialized countries such as the possibility of the disease becoming chronic in transplant patients, the immunocompromised in general, and even in patients with previous liver disease who are immunocompetent. In this comprehensive review, we summarize the current knowledge on HEV infection. PMID:24038432

  1. In Search of the Giant Squid

    NSDL National Science Digital Library

    The truth about this mysterious giant based on the exhibit by the National Museum of Natural History. A complete guide to the giant squid, including the different species of squid, how squid move, eat, and defend themselves, as well as photographs from the exhibit. Features also include information on the vessels and equipment used to investigate the giant squid, the locations where the giant squid were searched for, and a daily journal of the expedition.

  2. Chronic hepatitis C

    Microsoft Academic Search

    Tram T. Tran; Paul Martin

    2001-01-01

    Opinion statement  Infection with hepatitis C virus (HCV) accounts for 40% of cases of chronic liver disease in the United States and is now\\u000a the most common indication for liver transplantation. Estimates suggest that 4 million people (1.8%) of the American population\\u000a are or have been infected with HCV. Currently, the treatment of choice for patients with chronic HCV infection is

  3. Hepatitis C in veterans

    Microsoft Academic Search

    Edmund J. Bini

    2003-01-01

    Hepatitis C virus (HCV) infection is the most common chronic bloodborne infection in the United States and has recently been\\u000a identified as the single most important emerging pathogen in the Department of Veterans Affairs (VA) health care system. The\\u000a Third National Health and Nutrition Examination Survey estimated that 3.9 million Americans (1.8%) are infected with HCV.\\u000a In contrast, the prevalence

  4. Hepatitis E Virus Infection

    PubMed Central

    Dalton, Harry R.; Abravanel, Florence; Izopet, Jacques

    2014-01-01

    SUMMARY Hepatitis E virus (HEV) infection is a worldwide disease. An improved understanding of the natural history of HEV infection has been achieved within the last decade. Several reservoirs and transmission modes have been identified. Hepatitis E is an underdiagnosed disease, in part due to the use of serological assays with low sensitivity. However, diagnostic tools, including nucleic acid-based tests, have been improved. The epidemiology and clinical features of hepatitis E differ between developing and developed countries. HEV infection is usually an acute self-limiting disease, but in developed countries it causes chronic infection with rapidly progressive cirrhosis in organ transplant recipients, patients with hematological malignancy requiring chemotherapy, and individuals with HIV. HEV also causes extrahepatic manifestations, including a number of neurological syndromes and renal injury. Acute infection usually requires no treatment, but chronic infection should be treated by reducing immunosuppression in transplant patients and/or the use of antiviral therapy. In this comprehensive review, we summarize the current knowledge about the virus itself, as well as the epidemiology, diagnostics, natural history, and management of HEV infection in developing and developed countries. PMID:24396139

  5. Hepatitis - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... ?????? ????? ???????? - ??????? Bilingual PDF Health Information Translations Chinese - Simplified (????) Viral Hepatitis ????? - ???? (Chinese - Simplified) Bilingual PDF Health Information Translations Chinese - Traditional (????) Viral Hepatitis ????? - ???? (Chinese - ...

  6. Review of Giant cell arteritis

    PubMed Central

    Chacko, Joseph G.; Chacko, J. Anthony; Salter, Michael W.

    2014-01-01

    Giant-cell arteritis (GCA) is a systemic autoimmune disease affecting primarily the elderly. Giant cell arteritis can cause sudden and potentially bilateral sequential vision loss in the elderly. Therefore, it is considered a medical emergency in ophthalmology and a significant cause of morbidity in an increasingly aging population. Ophthalmologists need to be able to recognize the classic symptoms and signs of this disease, and then be able to work-up and treat these patients in an efficient manner. An in-depth review of GCA from the literature as well as personal clinical experience follows. PMID:25859139

  7. Review of Giant cell arteritis.

    PubMed

    Chacko, Joseph G; Chacko, J Anthony; Salter, Michael W

    2015-01-01

    Giant-cell arteritis (GCA) is a systemic autoimmune disease affecting primarily the elderly. Giant cell arteritis can cause sudden and potentially bilateral sequential vision loss in the elderly. Therefore, it is considered a medical emergency in ophthalmology and a significant cause of morbidity in an increasingly aging population. Ophthalmologists need to be able to recognize the classic symptoms and signs of this disease, and then be able to work-up and treat these patients in an efficient manner. An in-depth review of GCA from the literature as well as personal clinical experience follows. PMID:25859139

  8. Giant axonal neuropathy: MRS findings.

    PubMed

    Alkan, Alpay; Kutlu, Ramazan; Sigirci, Ahmet; Baysal, Tamer; Altinok, Tayfun; Yakinci, Cengiz

    2003-10-01

    Giant axonal neuropathy (GAN) is a rare genetic disease of childhood involving the central and peripheral nervous systems. Axonal loss with several giant axons filled with neurofilaments is the main histopathological feature of peripheral nerve biopsies in this disease. Routine neuroimaging studies reveal diffuse hyperintensities in cerebral and cerebellar white matter. In this case report, the authors present the brain magnetic resonance spectroscopic features (normal N-acetylaspartate/creatine and increased choline/creatine and myoinositol/creatine ratios), which might indicate the absence of neuroaxonal loss and the presence of significant demyelination and glial proliferation in white matter, of an 11-year-old boy diagnosed with GAN. PMID:14569833

  9. Radioembolization of hepatic tumors.

    PubMed

    Kennedy, Andrew

    2014-06-01

    Unresectable primary and metastatic liver tumors are a leading cause of cancer mortality and morbidity. This remains a challenging and key task for every oncologist despite significant advances that have been made with selective targeted systemic agents and in technology advances with radiotherapy delivery. Radioembolization (RE) is a technique of permanently implanting microspheres containing Yttrium-90 ((90)Y), a beta-emitting isotope with a treatment range of 2 mm, into hepatic tumors. This form of brachytherapy utilizes the unique dual vascular anatomy of the liver to preferentially deliver radioactive particles via the hepatic artery to tumor, sparing normal liver parenchyma. The main treatment inclusion criteria are patients with solid tumors, compensated liver functions, life expectancy of at least three months, and ECOG performance status 0-2. Benefit of RE has been proven in patients that have low-to-moderate extrahepatic disease burden, prior liver radiotherapy, heavy prior chemotherapy and biologic agent exposure, and history of hepatic surgery or ablation. Most of the clinical evidence is reported in metastatic colorectal, and neuroendocrine tumors (NET), and primary hepatocellular cancer. A growing body of data supports the use of RE in hepatic metastatic breast cancer, intrahepatic cholangiocarinoma, and many other metastatic tumor types. Side effects are typically mild constitutional and GI issues limited to the first 7-14 days post treatment, with only 6% grade 3 toxicity reported in large series. Potentially serious or fatal radiation induced liver disease is extremely rare, reported in only 1% or fewer in major series of both metastatic and primary tumors treated with RE. Currently, high priority prospective clinical trials are testing RE combined with chemotherapy in first line therapy for colorectal hepatic metastases, and combined with sorafenib for hepatocellular carcinomas (HCCs). Fortunately, this beneficial and now widely available therapy is being increasingly incorporated into the standard therapy algorithms of multidisciplinary GI cancer teams worldwide. This form of radiotherapy differs significantly from daily external beam radiotherapy in many ways, particularly in dose rate, dosimetric coverage and duration of radiation delivery, side effects, and patient selection factors. A wealth of experience using RE in solid tumors exists and ongoing major prospective clinical trials will soon clarify the role of RE in the management of metastatic colorectal liver metastases. PMID:24982766

  10. Immunology of hepatitis B virus and hepatitis C virus infection

    Microsoft Academic Search

    Michelina Nascimbeni; Barbara Rehermann

    2005-01-01

    More than 500 million people worldwide are persistently infected with the hepatitis B virus (HBV) and\\/or hepatitis C virus (HCV) and are at risk of developing chronic liver disease, cirrhosis and hepatocellular carcinoma. Despite many common features in the pathogenesis of HBV- and HCV-related liver disease, these viruses markedly differ in their virological properties and in their immune escape and

  11. Giant omental lipoma in children

    Microsoft Academic Search

    Xirong Luo; Wenzhong Gao; Jianghua Zhan

    2005-01-01

    Lipoma is a rare benign neoplasm of mature fat cells. Asymptomatic abdominal mass, progressive abdominal distension, and intraperitoneal radiolucent fat density mass on computed tomography are the main clinical symptoms and signs. An unusual case is presented in this report. A complete excision was performed on an 11-month-old boy with a giant omental lipoma, and no recurrence was found in

  12. Giant resonances in O-16 

    E-print Network

    Lui, YW; Clark, HL; Youngblood, David H.

    2001-01-01

    Giant resonances in O-16 have been studied with inelastic scattering of 240 MeV alpha particles at small angles, Isoscalar E0, E1, and E2 strength corresponding to 48 +/- 10%, 32 +/- 7%, and 53 +/- 10%, of the respective energy-weighted sum rule...

  13. Formation of the Giant Planets

    Microsoft Academic Search

    Hiroshi Mizuno

    1980-01-01

    The structure of a gaseous envelope surrounding a protoplanet has been investigated in connection with the formation of the giant planets. Under the assumptions of spherical symmetry and hydrostatic equilibrium, the structure has been calculated for the regions of Jupiter, Saturn, Uranus and Neptune. Energy transfer in the envelope has been taken into account precisely. When the core mass increases

  14. Giant Lipoma: A Case Report

    PubMed Central

    Zaroo, Mohammad Inam; Bashir, Sheikh Adil; Mohsin, Mir; Baba, Peerzada Umar Farooq; Farooq, Syed Suraiya Arjumand; Zargar, Haroon Rashid

    2011-01-01

    A lipoma is a fatty tissue tumor presenting as a painless slowly growing mass that can affect any part of the body rich in adipose tissue. Lipomas can be present in the thigh, shoulder, trunk, etc, although they are usually small. We are reporting a 65-year-old man with a giant lipoma involving his left buttock and lumbar region. PMID:23610489

  15. The peripheral giant cell granuloma.

    PubMed

    Warrington, R D; Reese, D J; Allen, G

    1997-01-01

    A peripheral giant cell granuloma can be seen as a pedunculated or broad-based lesion. Such lesions occur after age 20 years, with 50 percent of patients 40 to 59 years old. Frequently, there is a history of trauma to the region. PMID:9663087

  16. Eclipses of New Giant Exoplanets

    NASA Astrophysics Data System (ADS)

    Deming, Drake; Knutson, Heather; Kammer, Joshua; Fraine, Jonathan; Todorov, Kamen

    2013-10-01

    Although Kepler has dominated discussions of exoplanet statistics in recent years, ground-based transit surveys have been undergoing a quiet renaissance of their own that has resulted in the discovery of an ever-growing sample of hot gas giant planets around bright, nearby stars. Many of these new worlds give us a unique opportunity to resolve several outstanding questions in exoplanetary science, but these new planets are unobserved by Spitzer. Because the transit surveys have improved their ability to find short-period planets, we are now awash in hot giant planets, capable of being measured to high signal-to-noise at secondary eclipse in both Spitzer bands. We propose a focused statistical study based on observations of these new planets at secondary eclipse, in both Spitzer bands. We have calculated the scientifically optimum sample based on all of the currently unobserved planets, imposing a high signal-to-noise requirement. Our proposed observations of 28 new and hotter-than-average giant planets will address the nature and cause of temperature inversions in giant exoplanetary atmospheres, the existence (or not) or carbon-rich planets, the orbital evolution of these worlds, and the statistics of heat redistribution in the high-irradiance regime. Our observations will be an essential legacy for future complementary studies incorporating ground-based and HST observations.

  17. Protect Yourself against Hepatitis A and B: A Guide for Gay and Bisexual Men

    MedlinePLUS

    ... of hepatitis A vaccine. Will hepatitis A or hepatitis B vaccine protect me from hepatitis C? No. Hepatitis A, ... Australia should get vaccinated against hepatitis A virus. Hepatitis B vaccine is recommended for many travelers also. Discuss this ...

  18. Nursery of Giants

    NASA Technical Reports Server (NTRS)

    2004-01-01

    Hidden behind a shroud of dust in the constellation Cygnus is a stellar nursery called DR21, which is giving birth to some of the most massive stars in our galaxy. Visible light images reveal no trace of this interstellar cauldron because of heavy dust obscuration. In fact, visible light is attenuated in DR21 by a factor of more than 10,000,000,000,000,000,000,000,000,000,000,000,000,000 (ten thousand trillion heptillion).

    New images from NASA's Spitzer Space Telescope allow us to peek behind the cosmic veil and pinpoint one of the most massive natal stars yet seen in our Milky Way galaxy. The never-before-seen star is 100,000 times as bright as the Sun. Also revealed for the first time is a powerful outflow of hot gas emanating from this star and bursting through a giant molecular cloud.

    This image is a large-scale mosaic assembled from individual photographs obtained with the InfraRed Array Camera (IRAC) aboard Spitzer. The image covers an area about two times that of a full moon. The mosaic is a composite of images obtained at mid-infrared wavelengths of 3.6 microns (blue), 4.5 microns (green), 5.8 microns (orange) and 8 microns (red). The brightest infrared cloud near the top center corresponds to DR21, which presumably contains a cluster of newly forming stars at a distance of 10,000 light-years.

    Protruding out from DR21 toward the bottom left of the image is a gaseous outflow (green), containing both carbon monoxide and molecular hydrogen. Data from the Spitzer spectrograph, which breaks light into its constituent individual wavelengths, indicate the presence of hot steam formed as the outflow heats the surrounding molecular gas. Outflows are physical signatures of processes that create supersonic beams, or jets, of gas. They are usually accompanied by discs of material around the new star, which likely contain the materials from which future planetary systems are formed. Additional newborn stars, depicted in green, can be seen surrounding the DR21 region.

    The red filaments stretching across this image denote the presence of polycyclic aromatic hydrocarbons. These organic molecules, comprised of carbon and hydrogen, are excited by surrounding interstellar radiation and become luminescent at wavelengths near 8.0 microns. The complex pattern of filaments is caused by an intricate combination of radiation pressure, gravity and magnetic fields. The result is a tapestry in which winds, outflows and turbulence move and shape the interstellar medium.

    To the lower left of the mosaic is a large bubble of gas and dust, which may represent the remnants of a past generation of stars.

  19. Hepatitis C Virus and Cardiomyopathy

    Microsoft Academic Search

    Akira Matsumori

    2000-01-01

    The importance of hepatitis C virus infection has been recently noted in patients with hypertrophic cardiomyopathy or dilated cardiomyopathy. In a collaborative research project of the Committees for the Study of Idiopathic Cardiomyopathy, hepatitis C virus antibody was found in 74 of 697 patients (10.65) with hypertrophic cardiomyopathy and in 42 of 663 patients (6.3%) with dilated cardiomyopathy; these prevalences

  20. Adaptive Immunity in Autoimmune Hepatitis

    Microsoft Academic Search

    Maria Serena Longhi; Yun Ma; Giorgina Mieli-Vergani; Diego Vergani

    2010-01-01

    The histological lesion of interface hepatitis, with its dense portal cell infiltrate consisting of lymphocytes, monocytes\\/macrophages and plasma cells, was the first to suggest an autoaggressive cellular immune attack in the pathogenesis of autoimmune hepatitis (AIH). Immunohistochemical studies, focused on the phenotype of inflammatory cells infiltrating the liver parenchyma, have shown a predominance of ??-T cells. Amongst these cells, the

  1. Calpain and lipopolysaccharide mediated hepatitis

    E-print Network

    Rose, Robert Edward

    2009-06-02

    I INTRODUCTION?????????????????????? 1 II DEVELOPMENT OF THE NEUTROPHILIC HEPATITIS MODEL?... 5 Materials and Methods???????????????... 5 Results?????????????????????? 9 Discussion... II DEVELOPMENT OF THE NEUTROPHILIC HEPATITIS MODEL MATERIALS AND METHODS Animals and treatment All animal procedures were approved by the Texas A&M University Laboratory Animal Care Committee (ULACC) and conformed to the standards set forth...

  2. [Hepatitis in dogs; a review].

    PubMed

    Rothuizen, J; van den Ingh, T S

    1998-04-15

    As with most liver diseases, the symptoms of hepatitis in dogs are nearly always aspecific: the dogs eat less, are apathetic, sometimes have polyuria/polydipsia, and sometimes have diarrhoea. Hepatoencephalopathy and ascites only occur with these symptoms in very advanced stages of chronic hepatitis. Only a part of the dogs have jaundice. Because of these aspecific symptoms, the diagnosis hepatitis is often not taken into consideration, even though the presence of a liver disease can be easily detected by measuring plasma concentrations of alkaline phosphatase and bile acids, one or both of which are elevated. The diagnosis is confirmed by histological examination of a liver biopsy sample. The most common forms of hepatitis are non-specific reactive hepatitis, acute hepatitis, and chronic hepatitis. Non-specific reactive hepatitis is a reaction against endotoxin as a result of sepsis or an increased gastrointestinal absorption. Treatment is directed to the primary process. Leptospirosis also causes non-specific reactive hepatitis, but then renal insufficiency is the most prominent feature. The diagnosis is made not on the basis of a liver biopsy but on the basis of increased IgM titres against Leptospira. Immediate treatment with antibiotics and infusions at the first signs (jaundice and uraemia) can save the animal's life. Acute hepatitis can develop as a result of infection, toxins, or liver hypoxia. There is no specific treatment, but adequate recovery often occurs with supportive treatment. Corticosteroids are contraindicated. Chronic hepatitis, which can lead to cirrhosis, is the most common form of hepatitis. It is an autoimmune inflammatory reaction that is usually caused by a virus infection but sometimes by poisoning (intoxication). Long treatment with prednisolone or azathioprine is usually successful, but early recognition of the disease increases the likelihood of success. Nowadays, chronic hepatitis due to hepatic copper accumulation in Beddlington terriers can be detected by DNA tests. Such tests make it possible to distinguish between carriers and non-carriers. Affected animals can be kept symptom-free by life-long treatment with zinc gluconate or penicillamine. PMID:9584348

  3. Hepatitis B Vaccines

    Microsoft Academic Search

    Oren Shibolet; Daniel Shouval

    \\u000a Key Principles\\u000a \\u000a Initial immunization strategies against hepatitis B virus (HBV) infection concentrated on high-risk groups. This strategy,\\u000a which was successful in individual situations, failed to reduce the incidence and prevalence of HBV in the general population.\\u000a \\u000a \\u000a \\u000a As a result, in 1991 the World Health Organization (WHO) has recommended that HBV universal immunization should be integrated\\u000a into national immunization programs in

  4. Hepatic visceral larva migrans

    PubMed Central

    Rohilla, Seema; Jain, Nitin; Yadav, Rohtas; Dhaulakhandi, Dhara Ballabh

    2013-01-01

    Visceral larva migrans (VLM) is a systemic manifestation of migration of second stage larvae of nematodes through the tissue of human viscera. It is not uncommon but is underdiagnosed in developing countries. The liver is the most common organ to be involved due to its portal venous blood supply. The imaging findings are subtle and differentiation from hepatocellular carcinoma (HCC), metastases, cystic mesenchymal hamartoma and granulomatous diseases is difficult. This case report highlights the imaging features of hepatic lesions of VLM along with clinical and laboratory data which help in clinching the diagnosis. PMID:23853189

  5. Hepatic alveolar echinococcosis.

    PubMed

    Farrokh, Donya; Zandi, Behrouz; Pezeshki Rad, Masoud; Tavakoli, Maryam

    2015-03-01

     Alveolar hydatid disease is a highly malignant form of echinococcosis caused by the larvae of the cestode echinococcus multilocularis. Alveolar hydatid disease always affects the liver and can metastasise to the lung and brain. Early diagnosis and precise evaluation of the localization as well as the extent of lesions are essential for treatment. In this report, we present ultrasound and computed tomography findings in a patient with hepatic alveolar echinococcosis. The patient, who was presented with hepatomegaly, jaundice, and an infiltrative solid tumor, diagnosed by ultrasound and computed tomography. In contrast to hydatid cyst caused by echinococcus granulosus, this is a rare disease in Iran. PMID:25773697

  6. Immunopathogenesis of hepatitis C virus infection

    Microsoft Academic Search

    Anthony J Freeman; George Marinos; Rosemary A Ffrench; Andrew R Lloyd

    2001-01-01

    Hepatitis C virus, a recently identified member of the family Flaviviridae, is an important cause of chronic viral hepatitis and cirrhosis. There are similarities in the nature of the immune response to this pathogen with immunity in other flavivirus and hepatotropic virus infections, such as hepatitis B. However, the high rate of viral persistence after primary hepatitis C infection, and

  7. [Cholecystolithiasis as a cause of local hepatitis].

    PubMed

    Dolimov, K S; Il'khamov, F A; Abdumazhidov, A Sh; Tukhtamuradov, Z Z; Dolimov, T K; Pivnitski?, I O

    2014-08-01

    In an acute inflammation of gallbladder inflammatory process spreads on surrounding tissues, including hepatic tissue, what causes the regional hepatitis occurrence. In some patients, suffering calculous cholecystitis on background of transition of inflammatory process from gallbladder to hepatic tissue likewise a regional hepatitis, hyperbilirubinemia, the skin yellowness are revealed, what simulates choledocholithiasis and obturation jaundice. PMID:25417284

  8. Coinfection of Chronic Hepatitis B and Fasciolosis

    Microsoft Academic Search

    M. Demirci; M. Isler; B. Cicioglu Aridogan; A. Senol; M. Korkmaz

    2004-01-01

    Chronic hepatitis B and fasciolosis are associated with the induction of T-cell responses polarized to the Th2 subtype. Interferon-alpha enhances innate immunity as well as Th1 immune response. We present a male patient with chronic hepatitis B and fasciolosis who responded to chronic hepatitis treatment with hepatitis B virus (HBV) vaccine, interferon-alpha-2b and lamivudine.

  9. Utility of R2* Obtained from T2*-Weighted Imaging in Differentiating Hepatocellular Carcinomas from Cavernous Hemangiomas of the Liver

    PubMed Central

    Sun, Meiyu; Wang, Sheng; Song, Qingwei; Wang, Zhiyuan; Wang, Heqing; Ning, Dianxiu; Xu, Bin; Wei, Qiang; Liu, Ailian

    2014-01-01

    Purpose To evaluate the feasibility of applying R2* values to differentiate hepatocellular carcinomas (HCC) from cavernous hemangiomas of the liver (CHL). Materials and Methods This retrospective study was approved by the participating Institutional Review Board and written informed consent for all subjects were obtained. Seventy-three patients with 79 pathologically identified HCCs and 65 patients with 91 clinically or pathologically identified CHLs were enrolled in this study. All subjects underwent a breath-hold multi-echo T2* weighted MR imaging on a 1.5T clinical MR scanner. R2* values from HCC and CHL groups were compared using the Mann-Whitney non-parametric U test. A cut-off value of R2* was evaluated with receiver operator characteristic (ROC) analysis. Results The mean R2* value was 23.32±12.23 Hz (95% confidence interval [CI]: 20.58 Hz, 26.06 Hz) for the HCC group, and 3.66±2.37 Hz (95% CI: 3.17 Hz, 4.15 Hz) for the CHL group. The mean R2* value for HCC was significantly higher than that of CHL (p<0.001). A threshold of 9.48 Hz for the minimum R2* value in the diagnosis of HCC resulted in a sensitivity of 96.20% (76 out of 79 patients), and a specificity of 97.80% (89 out of 91 patients). The positive predictive value (PPV), negative predictive value (NPV) and diagnostic accuracy for HCC were 97.44% (76 out of 78 patients), 96.74% (89 out of 92 patients) and 97.06% (165 out of 170 patients), respectively. The AUC for differentiation between these two groups was 0.994 (95% CI: 0.980, 1.000). Conclusions R2* is a significant MRI biomarker to differentiate HCC from CHL with satisfying sensitivity and specificity. PMID:24632579

  10. VEGFR-1 mediates endothelial differentiation and formation of blood vessels in a murine model of infantile hemangioma.

    PubMed

    Boscolo, Elisa; Mulliken, John B; Bischoff, Joyce

    2011-11-01

    Vascular endothelial growth factor receptor-1 (VEGFR-1) is a member of the VEGFR family, and binds to VEGF-A, VEGF-B, and placental growth factor. VEGFR-1 contributes to tumor growth and metastasis, but its role in the pathological formation of blood vessels is still poorly understood. Herein, we used infantile hemangioma (IH), the most common tumor of infancy, as a means to study VEGFR-1 activation in pathological vasculogenesis. IH arises from stem cells (HemSCs) that can form the three most prominent cell types in the tumor: endothelial cells, pericytes, and adipocytes. HemSCs can recapitulate the IH life cycle when injected in immuncompromised mice, and are targeted by corticosteroids, the traditional treatment for IH. We report here that VEGF-A or VEGF-B induces VEGFR-1-mediated ERK1/2 phosphorylation in HemSCs and promotes differentiation of HemSCs to endothelial cells. Studies of VEGFR-2 phosphorylation status and down-regulation of neuropilin-1 in the HemSCs demonstrate that VEGFR-2 and NRP1 are not needed for VEGF-A- or VEGF-B-induced ERK1/2 activation. U0216-mediated blockade of ERK1/2 phosphorylation or shRNA-mediated suppression of VEGFR-1 prevents HemSC-to-EC differentiation. Furthermore, the down-regulation of VEGFR-1 in the HemSCs results in decreased formation of blood vessels in vivo and reduced ERK1/2 activation. Thus, our study reveals a critical role for VEGFR-1 in the HemSC-to-EC differentiation that underpins pathological vasculogenesis in IH. PMID:21945324

  11. Knockdown of IGF2R suppresses proliferation and induces apoptosis in hemangioma cells in vitro and in vivo.

    PubMed

    Ou, J-M; Lian, W-S; Qiu, M-K; Dai, Y-X; Dong, Q; Shen, J; Dong, P; Wang, X-F; Liu, Y-B; Quan, Z-W; Fei, Z-W

    2014-09-01

    Insulin-like growth factor-II (IGF-II)/IGF2R signaling plays a pivotal role in cell growth, migration and differentiation in many malignancies. An individual with high IGF-II expression levels has a high risk of developing cancer, but IGF2R is often considered to be a tumor suppressor. To date, little has been reported about the role of IGF-II/IGF2R signaling in hemangiomas (HAs). Thus, uncovering the mechanisms of IGF-II/IGF2R signaling is very important to understanding the development of HAs. In the present study, the expression of IGF-II and IGF2R was investigated in 27 cases of HAs of different phases by immunohistochemistry. Through lentivirus-mediated IGF2R siRNA (Lv-siIGF2R) in HA-derived endothelial cells (HDECs), we observed the effects of IGF2R knockdown on the biological behavior of HA cells. We found that the expression of IGF-II and IGF2R was significantly increased in proliferating phase HAs, but decreased in involuting phase HAs. Furthermore, knockdown of IGF2R in vitro significantly diminished the proliferative activity and induced apoptosis and cycle arrest with decreased expression of PCNA, Ki-67, Bcl-2, Cyclin D1 and E and increased the expression of Bax in the proliferative phase HAs (HDEC and CRL-2586 EOMA cells). In addition, the tumor volumes in a subcutaneous HDEC nude mouse model treated with Lv-siIGF2R were significantly smaller than those of the control group. Taken together, our findings indicate that the expression of IGF-II and IGF2R is increased in proliferating phase HAs, and knockdown of IGF2R suppresses proliferation and induces apoptosis in HA cells in vitro and in vivo, suggesting that IGF2R may represent a novel therapeutic target for the treatment of human HAs. PMID:24968760

  12. Contrast-enhanced ultrasonography in nodular splenomegaly associated with type B Niemann–Pick disease: an atypical hemangioma enhancement pattern

    PubMed Central

    Benedetti, E.; Proietti, A.; Miccoli, P.; Basolo, F.; Ciancia, E.; Erba, P.A.; Galimberti, S.; Orsitto, E.; Petrini, M.

    2009-01-01

    Introduction Niemann–Pick disease (NPD) types A and B are lipid storage disorders. NPD type A is a fatal disorder of infancy. Type B is a non-neuronopathic form observed in children and adults. It is associated with enlargement of the liver, spleen, or both, and nodular splenomegaly may be detected with ultrasound. Methods A 21-year-old female was admitted to the Emergency Room with fever, pharyngitis, and left upper quadrant abdominal pain. Labwork revealed anemia, thrombocytopenia, increased levels of AST, ALT, GGT, AF, LDH, triglycerides, and total cholesterol and low levels of HDL-cholesterol. PCR blood assays for CMV and EBV were both negative. Chest X-ray was unremarkable. Transabdominal B-mode ultrasound (US) revealed splenomegaly (long axis: >22 cm), an irregular subcapsular hypoechoic lesion in the superior pole that was consistent with splenic infarction, and multiple round highly echogenic nodes measuring 1–5 cm in diameter. Contrast-enhanced ultrasonography (CEUS) was performed using SonoVue® (Bracco). Results The presence of a splenic infarction was confirmed. The nodular lesions showed arterial-phase enhancement with late parenchymal phase wash-out. 18F-FDG-PET revealed splenic nodular uptake. Primary splenic lymphoma was suspected, and the patient underwent open splenectomy. The diagnosis was type B NPD with splenic hemangiomas. Discussion CEUS confirmed the diagnosis and extent of splenic infarction, but the nodular atypical enhancement pattern together with nodular 18F-FDG-PET uptake was misleading, suggesting as it did lymphoproliferative involvement of the spleen. PMID:23396497

  13. Association of multiple vertebral hemangiomas and severe paraparesis in a patient with a PTEN hamartoma tumor syndrome. Case report.

    PubMed

    Jenny, Benoit; Radovanovic, Ivan; Haenggeli, Charles-Antoine; Delavelle, Jacqueline; Rüfenacht, Daniel; Kaelin, André; Blouin, Jean-Louis; Bottani, Armand; Rilliet, Bénédict

    2007-10-01

    The PTEN hamartoma tumor syndrome, manifestations of which include Cowden disease and Bannayan-Riley-Ruvalcaba syndrome, is caused by various mutations of the PTEN gene located at 10q23. Its major criteria are macrocephaly and a propensity to develop breast and thyroid cancers as well as endometrial carcinoma. Minor diagnostic criteria include hamartomatous intestinal polyps, lipomas, fibrocystic disease of the breasts, and fibromas. Mutations of PTEN can also be found in patients with Lhermitte-Duclos disease (dysplastic gangliocytoma of the cerebellum). The authors report the case of a 17-year-old girl who had a severe cyanotic cardiac malformation for which surgery was not advised and a heterozygous missense mutation (c.406T>C) in exon 5 of PTEN resulting in the substitution of cysteine for arginine (p.Cysl36Arg) in the protein, which was also found in her mother and sister. The patient presented in the pediatric emergency department with severe spastic paraparesis. A magnetic resonance imaging study of the spine showed vertebral hemangiomas at multiple levels, but stenosis and compression were maximal at level T5-6. An emergency T5-6 laminectomy was performed. The decompression was extremely hemorrhagic because the rapid onset of paraparesis necessitated prompt treatment, and there was no time to perform preoperative embolization. The patient's postoperative course was uneventful with gradual recovery. This represents the first report of an association of a PTEN mutation and multiple vertebral angiomas. The authors did not treat the remaining angiomas because surgical treatment was contraindicated without previous embolization, which in itself would present considerable risk in this patient with congenital cyanotic heart disease. PMID:17941496

  14. [Prognosis of giant cell arteritis].

    PubMed

    Agard, Christian; Espitia, Olivier; Néel, Antoine

    2012-10-01

    The short-term prognosis of giant cell arteritis is associated to the risk of permanent visual loss, concerning 5-20% of patients, and mainly secondary to anterior ischaemic optic neuropathy. Most studies have suggested that long-term survival, around 80% at 5 years, is not impaired in giant cell arteritis. However, increased mortality has been often noticed in the year following diagnosis, especially related to cardiovascular disorders including aortitis (10-20% of cases), stroke (5-10% of cases), or myocardial infarction, commonly associated to atherosclerosis and to arterial hypertension. Aortic dissections or aneurysm ruptures are causes of death, which can therefore be directly related to the vasculitis. Most of the patients develop steroid related complications: infections that may lead to death, or osteoporosis in 20-40% of cases with a better prognosis than before thanks to preventive treatments. PMID:22950981

  15. [Hepatitis E: an emerging disease].

    PubMed

    Bonnet, D; Kamar, N; Izopet, J; Alric, L

    2012-06-01

    The hepatitis E virus is endemic in countries with poor sanitation, where it has many similarities with the hepatitis A virus. It causes a strictly human, feco-oral transmitted, acute, self-limited hepatitis in young adults. The outcome is excellent, except in pregnant women and cirrhotic patients, who experience a high mortality rate. The first cases described in industrialized countries were travellers coming from endemic areas. However, there is now growing evidence that locally-acquired hepatitis E is common in these areas, where it is an emergent disease, despite it is still misdiagnosed. In industrialized countries, hepatitis E spreads sporadically and has a predilection for elderly men with comorbidity, particularly chronic liver diseases. The mortality seems to be higher in this population. In these areas, hepatitis E is due to the genotype 3 virus that is thought to be zoonotically transmitted by pigs and wild boar. Hepatitis E may evolve towards a chronic infection in immunocompromised subjects, particularly in solid organ-transplanted patients. In case of chronic infection, it may cause liver fibrosis and cirrhosis. The diagnosis of hepatitis E is based on serological tests (IgM and IgG) and detection of the viral genome by reverse transcription polymerase chain reaction (RT-PCR) on blood and stools. Acute hepatitis E does not require any treatment but in chronically infected patients, a sustained viral response and finally a definitive viral clearance has been observed after a three-month course of low-dose ribavirin (600 to 800 mg/day). Two vaccines underwent successful human trials but are not yet commercially available. PMID:22405325

  16. Giants in the Local Region

    Microsoft Academic Search

    R. Earle Luck; Ulrike Heiter

    2007-01-01

    We present parameter and abundance data for a sample of 298 nearby giants. The spectroscopic data for this work have a resolution of R~60,000, S\\/N>150, and spectral coverage from 475 to 685 nm. Overall trends in the Z>10 abundances are dominated by Galactic chemical evolution, while the light-element abundances are influenced by stellar evolution, as well as Galactic evolution. We

  17. Giant Bubble Pinch-Off

    Microsoft Academic Search

    Raymond Bergmann; Meer van der Devaraj; Mark Stijnman; Marijn Sandtke; Andrea Prosperetti; Detlef Lohse

    2006-01-01

    Self-similarity has been the paradigmatic picture for the pinch-off of a drop. Here we will show through high-speed imaging and boundary integral simulations that the inverse problem, the pinch-off of an air bubble in water, is not self-similar in a strict sense: A disk is quickly pulled through a water surface, leading to a giant, cylindrical void which after collapse

  18. Neonatal Subependymal Giant Cell Astrocytoma

    Microsoft Academic Search

    Azedine Medhkour; David Traul; Muhammad Husain

    2002-01-01

    Subependymal giant cell astrocytoma (SEGCA) is a benign, slow-growing glial tumor that manifests with signs and symptoms of obstructive hydrocephalus most often in adolescent patients with tuberous sclerosis complex (TSC). Neonatal highly aggressive SEGCA is very rare. We report a 5-month-old child with TSC presenting with a cystic mass lesion in the left frontal lobe as well as multiple other

  19. Mass transfer from giant donors

    NASA Astrophysics Data System (ADS)

    Pavlovskii, K.; Ivanova, N.

    2015-06-01

    The stability of mass transfer in binaries with convective giant donors remains an open question in modern astrophysics. There is a significant discrepancy between what the existing methods predict for a response to mass-loss of the giant itself, as well as for the mass-transfer rate during the Roche lobe overflow. Here we show that the recombination energy in the superadiabatic layer plays an important and hitherto unaccounted-for role in the donor's response to mass-loss, in particular on its luminosity and effective temperature. Our improved optically thick nozzle method to calculate the mass-transfer rate via L1 allows us to evolve binary systems for a substantial Roche lobe overflow. We propose a new, strengthened criterion for the mass-transfer instability, basing it on whether the donor experiences overflow through its outer Lagrangian point. We find that with the new criterion, if the donor has a well-developed outer convective envelope, the critical initial mass ratio for which a binary would evolve stably through the conservative mass transfer varies from 1.5 to 2.2, which is about twice as large as previously believed. In underdeveloped giants with shallow convective envelopes, this critical ratio may be even larger. When the convective envelope is still growing, and in particular for most cases of massive donors, the critical mass ratio gradually decreases to this value, from that of radiative donors.

  20. Electrodynamics in Giant Planet Atmospheres

    NASA Astrophysics Data System (ADS)

    Koskinen, T.; Yelle, R. V.; Lavvas, P.; Cho, J.

    2014-12-01

    The atmospheres of close-in extrasolar giant planets such as HD209458b are strongly ionized by the UV flux of their host stars. We show that photoionization on such planets creates a dayside ionosphere that extends from the thermosphere to the 100 mbar level. The resulting peak electron density near the 1 mbar level is higher than that encountered in any planetary ionosphere of the solar system, and the model conductivity is in fact comparable to the atmospheres of Sun-like stars. As a result, the momentum and energy balance in the upper atmosphere of HD209458b and similar planets can be strongly affected by ion drag and resistive heating arising from wind-driven electrodynamics. Despite much weaker ionization, electrodynamics is nevertheless also important on the giant planets of the solar system. We use a generic framework to constrain the conductivity regimes on close-in extrasolar planets, and compare the results with conductivites based on the same approach for Jupiter and Saturn. By using a generalized Ohm's law and assumed magnetic fields, we then demonstrate the basic effects of wind-driven ion drag in giant planet atmospheres. Our results show that ion drag is often significant in the upper atmosphere where it can also substantially alter the energy budget through resistive heating.

  1. Intrathoracic giant solitary fibrous tumor

    PubMed Central

    Aydemir, Bülent; Çelik, Sezai; Okay, Tamer; Do?usoy, Ilgaz

    2013-01-01

    Background Solitary fibrous tumor of the pleura is a rare, usually benign, and slow-growing neoplasm. Complete surgical resection for giant tumor of the pleura is challenging because of poor exposure and a large blood supply. We report the case of a giant hypervascular fibrous tumor that filled nearly the entire left hemithorax and anterior mediastinum, and its preoperative management. Case Report: A 59-year-old woman presented to us with exertional dyspnea and chest pain. A chest radiograph showed the right hemithorax completely opaque and a mediastinal shift to the left hemithorax. A tomography scan of the thorax showed a giant mass that almost completely filled the right hemithorax and compressed the mediastinum to the left. Because of excessive bleeding during dissection, the operation was terminated after a biopsy specimen was obtained. The biopsy was diagnosed as a benign fibrous tumour. A thoracic computed tomography angiogram showed that the mass was supplied by multiple intercostal arteries as well as an aberrant artery that branches off the celiac trunk in the subdiaphragmatic region. Due to the many arteries that needed to be embolized, the final decision was to control the bleeding following resection by inducing total circulatory arrest with the help of cardiopulmonary bypass. The bleeding could not be controlled under cardiopulmonary bypass and the patient’s death was confirmed. Conclusions: We report this case to emphasize the necessity of preoperative embolization; the use of cardiopulmonary bypass and total circulatory arrest is not a valid alternative method to control the bleeding. PMID:23826442

  2. Kepler Rapidly Rotating Giant Stars

    NASA Astrophysics Data System (ADS)

    Costa, A. D.; Canto Martins, B. L.; Bravo, J. P.; Paz-Chinchón, F.; das Chagas, M. L.; Leão, I. C.; Pereira de Oliveira, G.; Rodrigues da Silva, R.; Roque, S.; de Oliveira, L. L. A.; Freire da Silva, D.; De Medeiros, J. R.

    2015-07-01

    Rapidly rotating giant stars are relatively rare and may represent important stages of stellar evolution, resulting from stellar coalescence of close binary systems or accretion of substellar companions by their hosting stars. In the present Letter, we report 17 giant stars observed in the scope of the Kepler space mission exhibiting rapid rotation behavior. For the first time, the abnormal rotational behavior for this puzzling family of stars is revealed by direct measurements of rotation, namely from photometric rotation period, exhibiting a very short rotation period with values ranging from 13 to 55 days. This finding points to remarkable surface rotation rates, up to 18 times the rotation of the Sun. These giants are combined with six others recently listed in the literature for mid-infrared (IR) diagnostics based on Wide-field Infrared Survey Explorer information, from which a trend for an IR excess is revealed for at least one-half of the stars, but at a level far lower than the dust excess emission shown by planet-bearing main-sequence stars.

  3. Young Brown Dwarfs & Giant Planets:Young Brown Dwarfs & Giant Planets: Recent Observations and ModelRecent Observations and Model

    E-print Network

    Young Brown Dwarfs & Giant Planets:Young Brown Dwarfs & Giant Planets: Recent Observations Early Evolution of Giant Planets Authors: J.J. Fortney, M.S. Marley, O.Authors: J.J. Fortney, M to the modelsRecent revision to the models #12;Brown Dwarf (BD) and Giant PlanetsBrown Dwarf (BD) and Giant

  4. The hepatic-arterial/portal-venous scintiangiogram in alcoholic hepatitis

    SciTech Connect

    Stewart, C.; Sakimura, I.; Siegel, M.E.; Harley, H.; Lee, K.

    1984-01-01

    This study was designed to identify abnormalities in the hepatic-arterial/portal-venous scintiangiogram (SA) in alcoholic hepatitis (AH). SA's were performed in 35 patients with acute alcoholic hepatitis (AAH), 8; acute alcoholic hepatitis superimposed on cirrhosis (A/C), 14; and cirrhosis (C), 13. Posterior flows were done with a bolus of 10 mCi Tc-99m sulfur colloid with computer time-activity curves over the liver and left kidney. Curves were analyzed for per cent of hepatic arterial (HA) and portal venous contribution using the slope ratio method. Hepatic arterialization was estimated from the angle of the HA component of the curve. Reversal of the relative contribution of the hepatic and portal components of total flow were seen in all groups. Although quite severe in AH, the degree of reversal could not be used to differentiate among the groups. The average HA angle in AAH was 48.3 +- 8.1, in A/C 41.5 +- 10.6, and in C 30.4 +- 12.1. In reviewing the data of only those in the acute clinical phase of AH and not the recovery phase (1 AAH, 3 A/C) and those without other causes of alteration in hepatic arterialization (1 hepatoma, 1 portalcaval shunt, 6 renal failure), the average HA angle in AAH was 50.1 +- 6.6, 45.4 +- 8.2 in A/C, and 23.2 +- 4.2 in C. In 6 with renal failure (2 C, 2AAH, 2 A/C) the HA angle ws 52.7 +- 5.7. In all cases cirrhosis could be differentiated from both A/C (P=.05) and AAH (P<.01) using the HA angle. In absence of renal failure, portal shunt, or hepatoma, P was <.01 in both comparisons.

  5. Hepatitis G virus infection in fulminant hepatic failure

    PubMed Central

    Saiz, J; Sans, M; Mas, A; Olmedo, E; Forns, X; Lopez-Labrador, F; Restrepo, J; Costa, J; Salmeron, J; Guilera, M; Ampurdanes, S; Sanchez-Tapias, J; de Anta, M T J.; Rodes, J

    1997-01-01

    Background—RNA sequences of the recently identified hepatitis GB virus C (HGBV-C), also named hepatitis G virus (HGV), have been detected in patients with idiopathic fulminant hepatic failure (FHF) but the role of this agent in the disease remains controversial. ?Aims—To investigate the presence and implications of HGV infection in a large series of Spanish patients with FHF. ?Patients—Sixty eight patients with FHF, including 19 with idiopathic disease, were studied. In 28 cases, studies were performed before and after liver transplantation. For comparison 200 volunteer blood donors and 22 patients transplanted for chronic liver disease were also studied. ?Methods—HGV RNA was measured in serum by reverse transcriptase polymerase chain reaction of the 5' non-coding region. ?Results—Evidence of HGV infection was found in 3% (6/200) of blood donors and in 19% (13/68) of patients with FHF. HGV infection was more frequent in patients with hepatitis B (24%, 6/25) or hepatitis D (42%, 5/12), than in patients with idiopathic disease (11%, 2/19). Half of the patients with HGV infection used illicit intravenous drugs. Specific clinical features associated with HGV infection were not identified. A very high rate of infection with HGV was observed in patients who underwent liver transplantation, either for FHF (60%, 15/24) or chronic liver disease (45%, 9/20). ?Conclusions—In our geographical area, HGV infection is relatively frequent in FHF, but it does not seem to play a major role in idiopathic cases. ?? Keywords: viral hepatitis; hepatitis G virus; fulminant hepatic failure; liver transplantation PMID:9414981

  6. Real-time ultrasonography as a monitoring technique for interstitial Nd:YAG laser treatment of voluminous hemangiomas and vascular malformations

    NASA Astrophysics Data System (ADS)

    Werner, Jochen A.; Gottschlich, Stefan; Lippert, Burkard M.; Folz, Benedikt J.

    1998-01-01

    Voluminous vascular anomalies of the head and neck region are still treated with conventional surgery although Neodymium:Yttrium-Aluminum-Garnet (Nd:YAG) laser therapy is an effective treatment method. One hundred thirty give patients with voluminous hemangiomas and vascular malformations were treated with interstitial Nd:YAG laser therapy, partly complemented by a non-contact mode Nd:YAG laser light application. The vascular tumors had a diameter of more than 3 cm in two or all three dimensions. Treatment was carried out under ultrasound and manual control. Nearly 60% of the patients showed a complete clinical regression of the vascular tumor, a third of the patients had a partial regression and were satisfied with the treatment outcome. Four patients were treated unsuccessfully with the laser and three of them subsequently underwent conventional surgery. Only 10 patients showed cosmetic and functional deficits. These results on the interstitial Nd:YAG laser therapy of voluminous hemangiomas and vascular malformations in a large patient group demonstrated the high effectiveness of this novel and innovative therapy modality.

  7. Cabergoline Treatment in Invasive Giant Prolactinoma

    PubMed Central

    Alsubaie, Sadeem; Almalki, Mussa H

    2014-01-01

    Patients with invasive giant prolactinoma suffer from a constellation of symptoms including headache, blurred vision, lethargy, and sexual dysfunction. Cabergoline, a potent dopamine agonist, is a known medication prescribed for the treatment of invasive giant prolactinoma. Here, we report a case of invasive giant prolactinoma in a 52-year-old Saudi male with dramatic response to cabergoline treatment clinically, biochemically, and radiologically. PMID:25002819

  8. Lithospheric footprints of giant orogenic gold systems

    Microsoft Academic Search

    F. P. Bierlein; D. I. Groves; R. J. Goldfarb; A. B. Christie

    Small orogenic gold deposits have the same deposit-scale geological and geochemical features as those that characterise giant orogenic gold systems (>16 Moz Au). Therefore, a broader-scale approach is needed to identify the critical controls on giant deposits and their disproportionate distribution throughout time and space. Ages of giant gold systems cluster around well-defined periods of lithospheric growth at continental margins,

  9. Finite size giant magnons and interactions

    E-print Network

    Olof Ohlsson Sax

    2008-11-04

    Magnon interactions give important contributions to the wrapping interactions of the N=4 spin-chain. Similar effects are expected for the finite size corrections to the giant magnon energy in AdS_5 x S^5. In this paper I review the finite gap description of giant magnons and the leading order calculation of the finite size corrections to the giant magnon dispersion relation for multi-magnon states.

  10. ORIGIN OF LITHIUM ENRICHMENT IN K GIANTS

    SciTech Connect

    Kumar, Yerra Bharat; Reddy, Bacham E. [Indian Institute of Astrophysics, Bengaluru 560034 (India); Lambert, David L. [McDonald Observatory, University of Texas, Austin, TX 78712 (United States)

    2011-03-20

    In this Letter, we report on a low-resolution spectroscopic survey for Li-rich K giants among 2000 low-mass (M {<=} 3 M{sub sun}) giants spanning the luminosity range from below to above the luminosity of the clump. Fifteen new Li-rich giants including four super Li-rich K giants (log {epsilon}(Li) {>=}3.2) were discovered. A significant finding is that there is a concentration of Li-rich K giants at the luminosity of the clump or red horizontal branch. This new finding is partly a consequence of the fact that our low-resolution survey is the first large survey to include giants well below and above the red giant branch (RGB) bump and clump locations in the H-R diagram. Origin of the lithium enrichment may be plausibly attributed to the conversion of {sup 3}He via {sup 7}Be to {sup 7}Li by the Cameron-Fowler mechanism but the location for the onset of the conversion is uncertain. Two possible opportunities to effect this conversion are discussed: the bump in the first ascent of the RGB and the He-core flash at the tip of the RGB. The finite luminosity spread of the Li-rich giants serves to reject the idea that Li enhancement is, in general, a consequence of a giant swallowing a large planet.

  11. Hepatitis B in pregnancy

    PubMed Central

    Borgia, Guglielmo; Carleo, Maria Aurora; Gaeta, Giovanni Battista; Gentile, Ivan

    2012-01-01

    Chronic hepatitis B virus (HBV) infection affects about 350 million individuals worldwide. Management of HBV infection in pregnancy is difficult because of several peculiar and somewhat controversial aspects. The aim of the present review is to provide a tool that may help physicians to correctly manage HBV infection in pregnancy. This review focuses on (1) the effect of pregnancy on HBV infection and of HBV infection on pregnancy; (2) the potential viral transmission from mother to newborn despite at-birth prophylaxis with immunoglobulin and vaccine; (3) possible prevention of mother-to-child transmission through antiviral drugs, the type of antiviral drug to use considering their efficacy and potential teratogenic effect, and the timing of their administration and discontinuation; and (4) the evidence for the use of elective caesarean section vs vaginal delivery and the possibility of breastfeeding. PMID:23002336

  12. Hepatic Encephalopathy: Historical Remarks

    PubMed Central

    Amodio, Piero

    2014-01-01

    The history of hepatic encephalopathy (HE) is briefly reviewed since the beginning of western medicine by Hippocrates. For about 2000 years the main evidence was the mere association between jaundice, fever and delirium. A clear link between delirium and cirrhosis was proven in the 17th century by Morgagni. In subsequent times the focus was manly the descriptions of symptoms and the only pathophysiological improvement was the evidence that jaundice, per se, does not alter brain function. Only at the end of the 19th century Hann et al proved the role of portal-systemic shunt and pf nitrogenous derivates in the pathophysiology of the syndrome. A terrific development of knowledge occurred in the last 60 years, after the works of Sherlock in London. Nowadays some consensus about HE was reached, so that new developments will likely occur. PMID:26041956

  13. Hepatic encephalopathy: historical remarks.

    PubMed

    Amodio, Piero

    2015-03-01

    The history of hepatic encephalopathy (HE) is briefly reviewed since the beginning of western medicine by Hippocrates. For about 2000 years the main evidence was the mere association between jaundice, fever and delirium. A clear link between delirium and cirrhosis was proven in the 17th century by Morgagni. In subsequent times the focus was manly the descriptions of symptoms and the only pathophysiological improvement was the evidence that jaundice, per se, does not alter brain function. Only at the end of the 19th century Hann et al proved the role of portal-systemic shunt and pf nitrogenous derivates in the pathophysiology of the syndrome. A terrific development of knowledge occurred in the last 60 years, after the works of Sherlock in London. Nowadays some consensus about HE was reached, so that new developments will likely occur. PMID:26041956

  14. Calpain and lipopolysaccharide mediated hepatitis 

    E-print Network

    Rose, Robert Edward

    2009-06-02

    This study tested the role of the calcium dependent cytosolic protein calpain in neutrophilic hepatitis. We hypothesized that inhibition of calpain would protect against LPS-induced neutrophilic liver damage. To test our hypothesis, a reliable LPS...

  15. FastStats: Viral Hepatitis

    MedlinePLUS

    ... States, 2014, table 37 [PDF - 9.8 MB] Mortality Number of deaths: 8,157 Deaths per 100, ... in Health Data Interactive Viral Hepatitis Related Links Mortality data Centers for Disease Control and Prevention: Viral ...

  16. Hepatic haemangiomata: diagnosis and management.

    PubMed Central

    Larcher, V F; Howard, E R; Mowat, A P

    1981-01-01

    Five cases of hepatic haemangioma are described, and a sixth (previously reported) is reviewed. Clinical features, investigation, and management are described to show the great variability of the complications and prognosis. Five children presented in the first 10 weeks of life with hepatomegaly; 4 developed congestive cardiac failure; 3 had cutaneous haemangiomata. One child presented at age 4 years with hepatomegaly and anaemia, and on investigation had features of chronic disseminated intravascular coagulation. Focal decrease or patchiness in hepatic uptake of technetium-99m colloid, and abnormal intrahepatic circulation was shown in all cases. In 3 children liver biopsy was performed to exclude malignant disease. In one patient there was spontaneous regression of the tumour by age 3 years. In 3 cases hepatic artery ligation was necessary to control congestive cardiac failure which had persisted despite treatment with digoxin, diuretics, and oral corticosteroids, a procedure which was without complications after up to 8 years. One infant with intractable portal hypertension, hepatic vein obstruction, and severe cholestasis died with persisting alimentary haemorrhage and intra-abdominal sepsis. One child aged 4 years showed no immediate response to hepatic artery ligation but the size of her tumour got smaller and the clinical features diminished after irradiation. These tumours cause considerable morbidity and have a high reported mortality. If congestive cardiac failure is not rapidly controlled, hepatic artery ligation should be performed. Images Fig. 1 Fig. 2 Fig. 3 Fig. 4 Fig. 5 Fig. 6 PMID:7469456

  17. Problems of protection against virus B hepatitis

    PubMed Central

    Polakoff, Sheila

    1976-01-01

    Various methods have been employed to reduce hepatitis B infections among patients and staff at high risk. Routine screening tests of all blood donors for hepatitis B surface antigen has reduced post-transfusion hepatitis B. After a control and prevention programme was instituted hepatitis B cross-infection was eliminated from haemodialysis units in Britain. Prophylaxis with specific immunoglobulin reduced attack rates of clinical hepatitis B, after accidental inoculation with infective material, to about 2%. Endemic hepatitis B in hospitals for the mentally subnormal remains a problem. PMID:981104

  18. Hepatitis regulation by the inflammasome signaling pathway.

    PubMed

    Negash, Amina A; Gale, Michael

    2015-05-01

    Hepatitis is damage and inflammation of the liver. It is triggered by both environmental and endogenous insults and is a platform for developing liver cirrhosis and cancer. Both innate and adaptive immune activation contribute to hepatic inflammation and disease. Viral hepatitis is the most common form of hepatitis and is typically associated with chronic viral infection. Alcohol-induced and non-alcoholic steatohepatitis are two rising hepatic problems. The innate immune inflammasome signaling cascade mediates the production of essential proinflammatory cytokines interleukin-1? (IL-1?) and IL-18. These cytokines regulate hepatic cell interaction and crosstalk of the various inflammatory pathways and influence disease outcome. PMID:25879290

  19. The Traces of Advertising Giants

    NSDL National Science Digital Library

    The Traces of Advertising Giants is an adverting history resource developed by graduate students at the University of Texas at Austin, Department of Advertising. The personal stories and professional profiles of infamous American advertisers are given, as well as hyperlinks to related topics and bibliographies for further research. Each decade in the twentieth and twenty-first centuries is covered through the present, and a few nineteenth century entries exist. Students will also benefit from the variety of web design techniques employed by UT authors, as well as the descriptions of historical tricks-of-the-trade.

  20. Tides in the giant planets

    NASA Technical Reports Server (NTRS)

    Hubbard, W. B.

    1974-01-01

    Goldreich and Soter's (1966) discussion of tidal dissipation in the Jovian planets is reexamined for planetary models which possess an appreciable internal heat source. The tidal torque produced in a fully liquid planet is calculated as a function of the average viscosity in the interior. Turbulent viscosity, which is produced by the convection of internal heat to the surface, seems to be capable of producing small (about a few per cent) changes in the orbits of the innermost satellites of Jupiter over the age of the solar system. The basic regularity of many of the giant planet satellite systems is probably due to other, perhaps primordial, causes.

  1. A Giant Hemorrhagic Adrenal Pseudocyst Case Report

    Microsoft Academic Search

    Goran Stimac; Josip Katusic; Mario Sucic; Mario Ledinsky; Bozo Kruslin; Davor Trnski

    2008-01-01

    Objective: To report a rare case of a giant hemorrhagic ad- renal pseudocyst and highlight the importance of this entity to clinicians. Case Presentation: A 57-year-old woman pre- sented with a 1-year history of abdominal pain and disten- sion. Ultrasonography and multislice computed tomogra- phy revealed a giant cystic (partially solid) mass over the left suprarenal region measuring 20 !

  2. Giant radioactive halos: indicators of unknown radioactivity?

    PubMed

    Gentry, R V

    1970-08-14

    A new group of giant radioactive halos has been found with radii in excess of anything previously discovered. Since alternate explanations for these giant halos are inconclusive at present, the possibility is considered that they originate with unknown alpha radioactivity, either from isomers of known elements or from superheavy elements. PMID:17791843

  3. Endoscopic snare excision of “giant” colorectal polyps

    Microsoft Academic Search

    Kenneth F. Binmoeller; Sabine Bohnacker; Hans Seifert; Frank Thonke; Hemant Valdeyar; Nib Soehendra

    1996-01-01

    Background: Endoscopic treatment of giant colorectal polyps remains controversial because of concerns regarding coexistent malignancy, incomplete resection, and safety. Methods: We reviewed the clinical course after removal of 176 benign-appearing large (>3 cm) colorectal polyps, which were removed by endoscopic snare resection in 170 patients. These were termed “giant” polyps. Sessile polyps (n = 129) were removed piecemeal and pedunculated

  4. Lessons from Giant-Scale Services

    Microsoft Academic Search

    Eric A. Brewer

    2001-01-01

    The past few years has seen an explosive growth in the size of infrastructur e services, particularly giant web sites and ISPs such as Yahoo!, AOL, Excite and others. Many new players are building these giant-scale services as well, including Microsoft, Disney, NBC, and CNN. In this paper, we look at the basic model followed by these services and examine

  5. Do red giants have short mode lifetimes?

    E-print Network

    D. Stello; H. Kjeldsen; T. R. Bedding; D. Buzasi

    2005-10-18

    We show evidence that the red giant star ksi Hya has an oscillation mode lifetime, tau, of about 2 days significantly shorter than predicted by theory (tau = 17 days, Houdek & Gough 2002). If this is a general trend of red giants it would limit the prospects of asteroseismology on these stars because of poor coherence of the oscillations.

  6. Giant Choledochal Cyst Mimicking Massive Gallbladder Hydrops in an Adult Patient: Multi Detector Computed Tomography and Magnetic Resonance Imaging Findings Correlated to Gross and Histopathological Findings

    PubMed Central

    Choi, Joon-Il; Lall, Chandana; Bhargava, Puneet; Imagawa, David K.

    2013-01-01

    Choledochal cysts are uncommon congenital anomalies of the biliary tree, commonly presenting in infancy, generally in the 1st year of life. Presentation in adult life is less common, accounting for 20% of cases. A 19-year-old female patient presented to the Emergency Department with severe abdominal distension, a palpable abdominal mass, mild jaundice and low grade fever. Ultrasound, computed tomography (CT) and magnetic resonance imaging of the abdomen showed a massive septated cystic lesion filling the entire abdomen with a significant mass effect on surrounding structures. Origin of the lesion was unclear and diagnosis included a giant mesenteric or duplication cyst, massive gallbladder with hydrops, biliary cystadenoma and giant choledochal cyst, among others. Final diagnosis was a Type IA choledochal cyst with massive asymmetric cystic dilatation of the extra-hepatic segments of the left hepatic duct with asymmetric dilatation of the right hepatic duct. Patient had an uneventful recovery after resection of the entire extrahepatic cyst and Roux-en-Y hepaticojejunostomy at the level of the hilum. In this article, we correlate CT and MRI findings to gross and histopathological findings of this giant Todani's Type IA choledochal cyst. PMID:24228213

  7. [An experimental study on hepatic arterial embolization with 131I-MMC-GM].

    PubMed

    Chen, X; Zhong, D; Wang, D; Tan, T; Yan, C; Li, X

    1991-03-01

    We designed a new gelatin microsphere (GM, 65 micron in diameter), which could combine with mitomycin C and 131I. The test in vitro showed that the GM had excellent drug release effect. Hepatic arterial embolization was carried out in 6 dogs with 131I-MMC-GM. The dogs survived from 4 to 28 days before being killed. Scintigraphy indicated that high radioactivity was concentrated in the liver, but was very low in the blood and thyroid. Pathologic study found that the GM was trapped in hepatic arterioles. The GM was eliminated by foreign body giant cells and the lumen of arterioles was occupied by granulations 14-28 days after operation. 131I-MMC-GM is a multiple anticancer agent which can exert triple action of targeting chemotherapy, internal radiotherapy and arterial embolization. PMID:1774027

  8. Giant Planet Formation, Evolution, and Internal Structure

    E-print Network

    Helled, Ravit; Podolak, Morris; Boley, Aaron; Meru, Farzana; Nayakshin, Sergei; Fortney, Jonathan J; Mayer, Lucio; Alibert, Yann; Boss, Alan P

    2013-01-01

    The large number of detected giant exoplanets offers the opportunity to improve our understanding of the formation mechanism, evolution, and interior structure of gas giant planets. The two main models for giant planet formation are core accretion and disk instability. There are substantial differences between these formation models, including formation timescale, favorable formation location, ideal disk properties for planetary formation, early evolution, planetary composition, etc. First, we summarize the two models including their substantial differences, advantages, and disadvantages, and suggest how theoretical models should be connected to available (and future) data. We next summarize current knowledge of the internal structures of solar- and extrasolar- giant planets. Finally, we suggest the next steps to be taken in giant planet exploration.

  9. Testing for the Hepatitis C Virus

    MedlinePLUS

    ... C Virus" /> Consumer Summary – Sept. 13, 2013 Testing for the Hepatitis C Virus Formats View PDF ( ... longer for bleeding to stop Understanding Hepatitis C Testing How do I know if I have the ...

  10. Surveillance for Viral Hepatitis - United States, 2012

    MedlinePLUS

    ... Home Page Share Compartir Surveillance for Viral Hepatitis – United States, 2012 Entire report in a printable format [PDF - ... Reported cases of acute hepatitis A, by state ? United States, 2008–2012 Table 2.2 Clinical characteristics of ...

  11. All Kids Need Hepatitis B Shots

    MedlinePLUS

    ... Newborn babies should receive their first shot of hepatitis B vaccine at birth before leaving the hospital. If your ... be done at the same visit as vaccinations. Hepatitis B vaccine is one of the safest vaccines available. It ...

  12. Hepatic tumor angiography: a subject review

    SciTech Connect

    Chuang, V.P.

    1983-09-01

    The dual blood supply of the normal hepatic parenchyma and the single arterial supply of hepatic neoplasms are important factors in the interpretation of celiac and hepatic arteriograms. Depending on whether the hepatic artery, portal vein, or both are opacified, three types of hepatogram can occur: arterial, portal, or mixed. On the celiac arteriogram, the densely opacified hepatic parenchyma makes the less well opacified tumor appear relatively hypovascular; and conversely, on the hepatic arteriogram the nonopacified portal flow has a ''wash-out'' effect on the normal parenchyma so that the neoplasm remains hypervascular. Thus most hepatic neoplasms are hypervascular on the hepatic arteriogram, and conversion of a hypervascular tumor to a hypovascular one is indicative of its response to treatment.

  13. [Treatment of hepatitis C].

    PubMed

    Schneider, M D; Kronenberger, B; Zeuzem, S; Sarrazin, C

    2015-04-01

    Chronic hepatitis C virus (HCV) infection is the major cause of liver cirrhosis, hepatocellular carcinoma and liver transplantation in the western world. The development and approval of nine directly acting antiviral drugs in recent years has led to a dramatic improvement in therapeutic efficacy accompanied by fewer side effects. With current treatment options sustained virologic response in more than 90?% of patients can be achieved depending on HCV genotype, liver cirrhosis and prior therapies. Modern HCV treatment regimens are interferon-free and should be administered for 12-24 weeks. Shorter courses are possible in selected patients. For the treatment of HCV genotype 1 infection combinations of either the nucleotide polymerase inhibitor sofosbuvir with the protease inhibitor simeprevir or with one of the two NS5A inhibitors daclatasvir or ledipasvir on the one hand or triple DAA therapy of paritaprevir, ombitasvir and dasabuvir on the other hand are applicable. Ribavirin has still a role as an add-on in difficult to treat patients. PMID:25762008

  14. Genetics Home Reference: Congenital hepatic fibrosis

    MedlinePLUS

    ... gastrointestinal ; gene ; hepatic ; hepatosplenomegaly ; hypertension ; infection ; inheritance ; inheritance pattern ; inherited ; intestine ; kidney ; lymph ; malformation ; polycystic kidney ; prevalence ; recessive ; renal ; ...

  15. Parvovirus B19 Associated Hepatitis

    PubMed Central

    Bihari, Chhagan; Rastogi, Archana; Saxena, Priyanka; Rangegowda, Devraj; Chowdhury, Ashok; Gupta, Nalini; Sarin, Shiv Kumar

    2013-01-01

    Parvovirus B19 infection can present with myriads of clinical diseases and syndromes; liver manifestations and hepatitis are examples of them. Parvovirus B19 hepatitis associated aplastic anemia and its coinfection with other hepatotropic viruses are relatively underrecognized, and there is sufficient evidence in the literature suggesting that B19 infections can cause a spectrum of liver diseases from elevation of transaminases to acute hepatitis to fulminant liver failure and even chronic hepatitis. It can also cause fatal macrophage activation syndrome and fibrosing cholestatic hepatitis. Parvovirus B19 is an erythrovirus that can only be replicate in pronormoblasts and hepatocytes, and other cells which have globosides and glycosphingolipids in their membrane can also be affected by direct virus injury due to nonstructural protein 1 persistence and indirectly by immune mediated injury. The virus infection is suspected in bone marrow aspiration in cases with sudden drop of hemoglobin and onset of transient aplastic anemia in immunosuppressed or immunocompetent patients and is confirmed either by IgM and IgG positive serology, PCR analysis, and in situ hybridization in biopsy specimens or by application of both. There is no specific treatment for parvovirus B19 related liver diseases, but triple therapy regimen may be effective consisting of immunoglobulin, dehydrohydrocortisone, and cyclosporine. PMID:24232179

  16. Hepatic manifestations of metabolic syndrome.

    PubMed

    Medina-Santillán, Roberto; López-Velázquez, Jorge A; Chávez-Tapia, Norberto; Torres-Villalobos, Gonzalo; Uribe, Misael; Méndez-Sánchez, Nahum

    2013-03-01

    The prevalence of metabolic syndrome is growing around the world at an alarming rate. Obesity involves a plethora of molecules that predispose individuals to an inflammatory state and various metabolic complications. Dysregulation of nutrient metabolism is a key step during the progression of chronic liver disease that induces an inflammatory state, cellular damage, and impaired hepatic insulin signaling, which leads to insulin resistance. Insulin resistance arises from multiple defects in the liver, adipose tissues, and muscle signaling, which leads to a failure to suppress hepatic gluconeogenesis and glycogenolysis, thereby enhancing fat accumulation in the hepatocytes via increased lipolysis and increased hepatic synthesis of triglycerides. This metabolic condition also increases the frequency of other comorbidities such as liver and biliary diseases. Nonalcoholic fatty liver disease is the hepatic expression of metabolic syndrome, which comprises a spectrum of clinical and histological events ranging from simple and benign fatty liver to steatohepatitis, which is characterized by the abnormal activation of pathways leading to an aggressive inflammatory condition. This pathological state may progress to more severe damage known as cirrhosis, which endangers the anatomy and function of liver tissue. In addition, a small group of patients with end-stage liver disease may develop hepatocellular carcinoma and finally death. By contrast, cholesterol gallstone disease is a common metabolic disease, and is considered to be the main biliary indicator of metabolic syndrome. This review provides a detailed summary of the hepatic manifestations associated with metabolic syndrome. Copyright © 2013 John Wiley & Sons, Ltd. PMID:23471889

  17. In vitro maturation of follicular oocytes of the Giant Panda (Ailuropoda melanoleuca): a case report.

    PubMed

    Zhang, M J; Hou, R; Zhang, A J; Zhang, Z H; He, G X; Li, G H; Wang, J S; Li, S C; Song, Y F; Fei, L S; Chen, H W

    1998-05-01

    The Giant Panda is an endangered species that would benefit from biotechnological assistance in reproduction. However, because there are only a few of these animals left in the world, scientists hesitate to use them for research procedures. We were fortunate to obtain ovaries from a Giant Panda that died of hepatic cirrhosis during the nonbreeding season. Oocytes were harvested within 4 h of death by dissecting the ovarian cortex in physiological saline and collecting the cumulus-oocyte complexes from the fluid, and then were classified into large (> 125 microns) and small (100 to 124 microns) follicular oocytes and placed in TCM199 supplemented with FSH (10 micrograms/mL) and LH (20 micrograms/mL). After culture for 22 h at 37 degrees C in air with 5% CO2, response was evaluated by growth of oocytes and presence of the first polar body. Of the 26 large follicular oocytes that were harvested, 12 were considered suitable for IVM, and 14 were degenerated, had a broken zona pellucida or had lost some cytoplasm. Of the 12 cultured oocytes, all grew to a mean diameter of 141.1(SD = +/- 6.7, n = 12), and 4 released the first polar body. None of the small follicular oocytes showed growth or other signs of maturation. We conclude from our preliminary results that it is possible to obtain functional Giant Panda oocytes from ovaries obtained post mortem during the nonbreeding season. PMID:10732062

  18. RELATED ARTICLES Pricey Hepatitis C Drug Draws

    E-print Network

    Bogyo, Matthew

    as this dangerous alphabet of infectious diseases Hepatitis A,B,C,D, and E kills nearly as many people as does HIV/AIDS. Hepatitis B and C are most well known and justifiably feared because they cause chronic liver cirrhosis and liver cancer, very often leading to death. Hepatitis B is transmitted from an infected mother to her

  19. 78 FR 46247 - World Hepatitis Day, 2013

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-31

    ...threats, and both hepatitis B and C can become chronic...disease. Vaccines for hepatitis A and B are crucial to preventing...is no vaccine against hepatitis C, but through early...and in many cases even cure the infection....

  20. Hepatic toxicity resulting from cancer treatment

    Microsoft Academic Search

    Theodore S. Lawrence; John M. Robertson; Mitchell S. Anscher; Randy L. Jirtle; William D. Ensminger; Luis F. Fajardo

    1995-01-01

    Radiation-induced liver disease (RILD), often called radiation hepatitis, is a syndrome characterized by the development of anicteric ascites approximately 2 weeks to 4 months after hepatic irradiation. There has been a renewed interest in hepatic irradiation because of two significant advances in cancer treatment: three dimensional radiation therapy treatment planning and bone marrow transplantation using total body irradiation. RILD resulting

  1. 79 FR 44257 - World Hepatitis Day, 2014

    Federal Register 2010, 2011, 2012, 2013, 2014

    2014-07-31

    ...Proclamation 9151 of July 25, 2014 World Hepatitis Day, 2014 By the President of the United...in twelve people are living with viral hepatitis. In the United States, millions of...unaware of their infection status. Viral hepatitis can persist undetected for many...

  2. Taxonomic Classification of Hepatitis A Virus

    Microsoft Academic Search

    Ian D. Gust; Anthony G. Coulepis; Stephen M. Feinstone; Stephen A. Locarnini; Yasuo Moritsugu; Raphael Najera; Gunter Siegl

    1983-01-01

    Summary Sufficient data have accumulated to permit the ICTV Ad Hoc Study Group on the Taxonomy of Hepatitis Viruses to recognize hepatitis A virus as a picornavirus. Within the family Picornaviridae, hepatitis A virus closely resembles members of the genus Enterovirus.Copyright © 1983 S. Karger AG, Basel

  3. Drug-induced chronic hepatic disease.

    PubMed

    Zimmerman, H J

    1979-05-01

    A number of chronic hepatic lesions can result from adverse reactions to medicinal agents. Such lesions include a form of chronic active hepatitis; hepatic steatosis, phoepholipidosis and granulomatosis; several vascular lesions; two types of noncirrhotic portal hypertension; several types of cirrhosis and several neoplasms. PMID:221760

  4. Hepatitis B vaccine nonresponse and celiac disease

    Microsoft Academic Search

    Kyung W. Noh; Gregory A. Poland; Joseph A. Murray

    2003-01-01

    OBJECTIVES:There is a genetic predisposition to hepatitis B vaccine nonresponse. The link between human leukocyte antigen (HLA) genotype and ineffective development of immunity to the hepatitis B vaccine has been characterized in multiple studies. Celiac disease has a strong association with a particular HLA genotype of DQ2; interestingly, this HLA genotype is seen in association with nonresponders to the hepatitis

  5. THE ORBITAL EVOLUTION OF GAS GIANT PLANETS AROUND GIANT STARS

    SciTech Connect

    Villaver, Eva [Universidad Autonoma de Madrid, Departamento de fisica Teorica C-XI, 28049 Madrid (Spain); Livio, Mario, E-mail: eva.villaver@uam.e, E-mail: mlivio@stsci.ed [Space Telescope Science Institute, 3700 San Martin Drive, Baltimore, MD 21218 (United States)

    2009-11-01

    Recent surveys have revealed a lack of close-in planets around evolved stars more massive than 1.2 M{sub sun}. Such planets are common around solar-mass stars. We have calculated the orbital evolution of planets around stars with a range of initial masses, and have shown how planetary orbits are affected by the evolution of the stars all the way to the tip of the red giant branch. We find that tidal interaction can lead to the engulfment of close-in planets by evolved stars. The engulfment is more efficient for more-massive planets and less-massive stars. These results may explain the observed semimajor axis distribution of planets around evolved stars with masses larger than 1.5 M{sub sun}. Our results also suggest that massive planets may form more efficiently around intermediate-mass stars.

  6. Dental infection with hepatitis B.

    PubMed

    Williams, S V; Pattison, C P; Berquist, K R

    1975-06-23

    We performed a prospective study to assess the risk of patients acquiring infection following routine professional contact with two dentists incubating type B viral hepatitis. Serum samples from patients exposed during the six weeks before onset of hepatitis in the dentists were tested for hepatitis B surface antigen and for antibody to the antigen shortly after illness developed and again six months later. Household members of exposed patients served as a control group. None of the exposed patients or controls became ill with hepititis, and none developed antigen. Three of the 237 exposed patients developed antibody, as did four of the 245 controls. The difference between exposed patients and controls was not significant. These results do not support the hypothesis that these two dentists transmitted infection to their patients. PMID:805849

  7. Drug-induced hepatic steatosis.

    PubMed

    Amacher, David E; Chalasani, Naga

    2014-05-01

    Several drugs have been associated with the potential for drug-induced hepatic steatosis (DIHS) and/or phospholipidosis (DIPL), a lysosomal storage disorder. Drug-induced hepatic steatosis is generally a chronic but reversible affliction and may involve drug accumulation in the liver. Fat accumulation may be either macrovesicular or microvesicular in nature. Commonly used medications associated with DIHS include amiodarone, valproate, tamoxifen, methotrexate, and some chemotherapeutic and antiretroviral agents. Two recently approved medications for the treatment of hereditary homozygous hypercholesterolemia have also been noted to cause hepatic steatosis. For some compounds such as methotrexate and tamoxifen, the underlying metabolic risk factors such as obesity and metabolic syndrome may exacerbate their potential to cause DIHS and its progression. In this article, the authors discuss the preclinical screening and mechanisms of DIHS and DIPL, and review specific examples of drugs commonly used in clinical practice that are known to cause DIHS. PMID:24879984

  8. [Hepatitis C and insulin resistance].

    PubMed

    Seirafi, Mariam; Negro, Francesco

    2008-09-01

    In the course of a chronic infection with the hepatitis C virus, the fibrosis progression rate varies among individuals, and depends on the existence of certain co-factors. In this context, a growing interest has emerged and has focused on insulin resistance. In fact, the hepatitis C virus is now recognized as being responsible for a direct interference with the insulin signalling pathway. This insulin resistance of viral origin, in combination with an eventual insulin resistance associated with an existing metabolic syndrome, can therefore accelerate its evolution to a type II diabetes. Independently of its pathogenesis, insulin resistance occurring in chronic hepatitis C causes a fatty liver, contributes to the progression towards cirrhosis, and narrows the chances of a successful antiviral therapy. It is therefore crucial to recognize it in order to correct it. PMID:18831405

  9. Aloe-induced Toxic Hepatitis

    PubMed Central

    Yang, Ha Na; Kim, Young Mook; Kim, Byoung Ho; Sohn, Kyoung Min; Choi, Myung Jin; Choi, Young Hee

    2010-01-01

    Aloe has been widely used in phytomedicine. Phytomedicine describes aloe as a herb which has anti-inflammatory, anti-proliferative, anti-aging effects. In recent years several cases of aloe-induced hepatotoxicity were reported. But its pharmacokinetics and toxicity are poorly described in the literature. Here we report three cases with aloe-induced toxic hepatitis. A 57-yr-old woman, a 62-yr-old woman and a 55-yr-old woman were admitted to the hospital for acute hepatitis. They had taken aloe preparation for months. Their clinical manifestation, laboratory findings and histologic findings met diagnostic criteria (RUCAM scale) of toxic hepatitis. Upon discontinuation of the oral aloe preparations, liver enzymes returned to normal level. Aloe should be considered as a causative agent in hepatotoxicity. PMID:20191055

  10. Test-bolus injection for optimization of arterial phase imaging during contrast-enhanced hepatic MR imaging.

    PubMed

    Yu, J S; Kim, K W; Jo, B J; Jeong, M G; Kim, J K; Hahm, J K; Lee, J T; Yoo, H S

    2000-08-01

    Contrast enhancement during the dynamic MR imaging is important for the detection and characterization of focal liver lesions. The purpose of this study was to determine whether or not a timing examination with a injection of a 1.0-mL bolus of gadopentetate dimeglumine into the antecubital vein followed by rapid dynamic scanning and measurement of signal intensity of the aorta could help to obtain proper arterial-dominant phase images for the characterization of focal hepatic lesions during subsequent multiphase dynamic MR imaging. The imaging delay to acquisition of the first gadolinium-enhanced image for multiphase dynamic MR imaging was set to equal the time to peak aortic enhancement during the test examination. The first contrast-enhanced images of 80 patients with 160 focal liver lesions (hepatocellular carcinoma, n = 79; cavernous hemangioma, n = 51; metastatic tumor, n = 30) were then retrospectively reviewed. Peak aortic enhancement occurred between 10 and 28 seconds (mean, 16.5 seconds +/- 3.1) after starting the infusion of contrast material in 80 patients during the test-examination. Depending on the findings of intrahepatic vascular enhancement on the full-scale dynamic images, hepatic arterial phase (n = 11, 14%) or sinusoid phase (n = 65, 81%) imaging was obtained during the first gadolinium-enhanced acquisition in 76 (95%) of 80 patients. Three different lesions were well characterized and easily distinguished from each other (p < .0001) on the first-phase images depending on their enhancement pattern. In the majority of patients, timing examination with test-bolus injection was helpful in obtaining qualified images for the characterization of various focal lesions. PMID:10992807

  11. Red giant variables: OGLE--II and MACHO

    E-print Network

    L. L. Kiss; P. Lah

    2005-09-21

    We review the recent impact of microlensing projects on our understanding of pulsating red giant stars. Discussed are red giant stars' pulsation properties (period--luminosity relations, period changes, mode switchings), Red Giant Branch pulsations, metallicity effects and the use of red giant variables to explore galactic structure.

  12. Diagnosis and management of hepatic focal nodular hyperplasia

    Microsoft Academic Search

    A. Venturi; F. Piscaglia; G. Vidili; S. Flori; R. Righini; R. Golfieri; L. Bolondi

    2007-01-01

    Focal nodular hyperplasia (FNH) is the second most common benign tumor of the liver, after hemangioma. It is generally found incidentally and is most common in reproductive-aged women, but it also affects males and can be diagnosed at any age. Patients are rarely symptomatic, but FNH sometimes causes epigastric or right upper quadrant pain. The main clinical task is to

  13. Hepatitis C, stigma and cure

    PubMed Central

    Marinho, Rui Tato; Barreira, David Pires

    2013-01-01

    The infection with hepatitis C virus (HCV) is one of the most important global chronic viral infections worldwide. It is estimated to affect around 3% of the world population, about 170-200 million people. Great part of the infections are asymptomatic, the patient can be a chronic carrier for decades without knowing it. The most severe consequences of the chronic infection are liver cirrhosis and hepatocellular carcinoma, which appears in 20%-40% of the patients, leading to hepatic failure and death. The HCV was discovered 25 years ago in 1989, is a RNA virus and classified by the World Health Organization as an oncogenic one. Hepatocellular carcinoma is one of the most important cancers, the fifth worldwide in terms of mortality. It has been increasing in the Ocidental world, mainly due to chronic hepatitis C. Hepatitis C is not only a liver disease and a cause of cirrhosis, but also a mental, psychological, familiar, and social disease. The stigma that the infected person sometimes carries is tremendous having multiple consequences. The main cause is lack of adequate information, even in the health professionals setting. But, besides the “drama” of being infected, health professionals, family, society and the infected patients, must be aware of the chance of real cure and total and definitive elimination of the virus. The treatment for hepatitis C has begun in the last 80´s with a percentage of cure of 6%. Step by step the efficacy of the therapy for hepatitis C is rapidly increasing and nowadays with the very new medications, the so called Direct Antiviral Agents-DAAs of new generation, is around 80%-90%. PMID:24187444

  14. Hepatic lipase deficiency.

    PubMed

    Connelly, P W; Hegele, R A

    1998-12-01

    Hepatic lipase (HL) is an enzyme that is made primarily by hepatocytes (and also found in adrenal gland and ovary) and hydrolyzes phospholipids and triglycerides of plasma lipoproteins. It is secreted and bound to the hepatocyte surface and readily released by heparin. It is a member of the lipase superfamily and is homologous to lipoprotein lipase and pancreatic lipase. The enzyme can be divided into an NH2-terminal domain containing the catalytic site joined by a short spanning region to a smaller COOH-terminal domain. The NH2-terminal portion contains an active site serine in a pentapeptide consensus sequence, Gly-Xaa-Ser-Xaa-Gly, as part of a classic Ser-Asp-His catalytic triad, and a putative hinged loop structure covering the active site. The COOH-terminal domain contains a putative lipoprotein-binding site. The heparin-binding sites may be distributed throughout the molecule, with the characteristic elution pattern from heparin-sepharose determined by the COOH-terminal domain. Of the three N-linked glycosylation sites, Asn-56 is required for efficient secretion and enzymatic activity. HL is hypothesized to directly couple HDL lipid metabolism to tissue/cellular lipid metabolism. The potential significance of the HL pathway is that it provides the hepatocyte with a mechanism for the uptake of a subset of phospholipids enriched in unsaturated fatty acids and may allow the uptake of cholesteryl ester, free cholesterol, and phospholipid without catabolism of HDL apolipoproteins. HL can hydrolyze triglyceride and phospholipid in all lipoproteins, but is predominant in the conversion of intermediate density lipoproteins to LDL and the conversion of post-prandial triglyceride-rich HDL into the postabsorptive triglyceride-poor HDL. HL plays a secondary role in the clearance of chylomicron remnants by the liver. Human post-heparin HL activity is inversely correlated with intermediate density lipoprotein cholesterol concentration only in subjects with a hyperlipidemia involving VLDL. This is consistent with intermediate-density lipoproteins being a substrate for HL. HDL cholesterol has been reported to be inversely correlated to HL activity, and on this basis it has been suggested that lowering HL would increase HDL cholesterol. However, the correlation could also be due to a common hormonal factor such as estrogen, which has been shown to up-regulate apoAI and HDL cholesterol and lower HL. A striking feature of severe deficiency of HL is the increase in HDL cholesterol and apolipoprotein AI and an approximately 10-fold increase in HDL triglyceride. Hyper-alpha-triglyceridemia is not a feature of antiatherogenic HDL. HL binds not only to heparan, but also to the LDL receptor-related protein. It has been suggested that enzymatically inactive HL can play a role in hepatic lipoprotein uptake, forming a "bridge" by binding to the lipoprotein and to the cell surface. This raises the interesting possibility that production and secretion of mutant inactive HL could promote clearance of VLDL remnants. We have described a rare family with HL deficiency. Affected patients are compound heterozygotes for a mutation of Ser267 to Phe that results in an inactive enzyme and a mutation of Thr383 to Met that results in impaired secretion and reduced specific activity. Human HL deficiency in the context of a second factor causing hyperlipidemia is strongly associated with premature coronary artery disease. Recently, it has been reported that mutations affecting the structure of HL (e.g., T383M) are relatively frequent in the Finnish population. A C-to-T polymorphism in the promotor region of the HL gene is associated with lowered HL activity and less strongly with increased HDL cholesterol. In summary, there is a good understanding of what HL does in lipoprotein metabolism; however, there is little understanding of its physiological importance, that is, why HL does what it does. (ABSTRACT TRUNCATED) PMID:9885775

  15. Sunspots and Giant-Cell Convection

    NASA Astrophysics Data System (ADS)

    Moore, R.; Hathaway, D.; Reichmann, E.

    2000-05-01

    From analysis of Doppler velocity images from SOHO/MDI, Hathaway et al (2000, Solar Phys., in press) have found clear evidence for giant convection cells that fill the solar surface, have diameters 3-10 times that typical of supergranules, and have lifetimes ? 10 days. Analogous to the superposition of the granular convection on the supergranular convection, the ~ 30,000 km diameter supergranules are superposed on these still larger giant cells. Because the giant cells make up the large-scale end of a continuous power spectrum that peaks at the size scale of supergranules, it appears that the giant cells are made by the same mode of convection as the supergranules. This suggests that the giant cells are similar to supergranules, just longer-lived, larger in diameter, and deeper. Here we point out that the range of lengths of large bipolar sunspot groups is similar to the size range of giant cells. This, along with the long lives (weeks) of large sunspots, suggests that large sunspots sit in long-lived, deep downflows at the corners of giant cells, and that the distance from leader to follower sunspots in large bipolar groups is the distance from one giant-cell corner to the next. By this line of reasoning, an unusually large and strong downdraft might pull in both legs of a rising spot-group magnetic flux loop, resulting in the formation of a delta sunspot. This leads us to suggest that a large, strong giant-cell corner downdraft should be present at the birthplaces of large delta sunspots for some time (days to weeks) before the birth. Thus, early detection of such downdrafts by local helioseismology might provide an early warning for the formation of those active regions (large delta sunspot groups) that produce the Sun's most violent flares and coronal mass ejections. This work is supported by NASA's Office of Space Science through the Solar Physics Branch of its Sun-Earth Connection Program.

  16. Diagnosis of Minimal Hepatic Encephalopathy

    PubMed Central

    Weissenborn, Karin

    2014-01-01

    Minimal hepatic encephalopathy (mHE) has significant impact upon a liver patient's daily living and health related quality of life. Therefore a majority of clinicians agree that mHE should be diagnosed and treated. The optimal means for diagnosing mHE, however, is controversial. This paper describes the currently most frequently used methods—EEG, critical flicker frequency, Continuous Reaction time Test, Inhibitory Control Test, computerized test batteries such as the Cognitive Drug Research test battery, the psychometric hepatic encephalopathy score (PHES) and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS)—and their pros and cons.

  17. Diagnosis of minimal hepatic encephalopathy.

    PubMed

    Weissenborn, Karin

    2015-03-01

    Minimal hepatic encephalopathy (mHE) has significant impact upon a liver patient's daily living and health related quality of life. Therefore a majority of clinicians agree that mHE should be diagnosed and treated. The optimal means for diagnosing mHE, however, is controversial. This paper describes the currently most frequently used methods-EEG, critical flicker frequency, Continuous Reaction time Test, Inhibitory Control Test, computerized test batteries such as the Cognitive Drug Research test battery, the psychometric hepatic encephalopathy score (PHES) and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS)-and their pros and cons. PMID:26041959

  18. Replication of hepatitis C virus.

    PubMed

    Moradpour, Darius; Penin, François; Rice, Charles M

    2007-06-01

    Exciting progress has recently been made in understanding the replication of hepatitis C virus, a major cause of chronic hepatitis, liver cirrhosis and hepatocellular carcinoma worldwide. The development of complete cell-culture systems should now enable the systematic dissection of the entire viral lifecycle, providing insights into the hitherto difficult-to-study early and late steps. These efforts have already translated into the identification of novel antiviral targets and the development of new therapeutic strategies, some of which are currently undergoing clinical evaluation. PMID:17487147

  19. Drizzle correlations with giant nuclei

    NASA Astrophysics Data System (ADS)

    Hudson, James G.; Jha, Vandana; Noble, Stephen

    2011-03-01

    Giant nuclei (GN) concentrations (NGN) below RICO small cumulus clouds were substantially correlated with drizzle drop concentrations (Nd), especially at higher cloud altitudes. The NGN-Nd correlation coefficients (R) progressively increased with altitude whereas R for CCN concentrations with Nd were negative with mostly decreasing magnitudes at increasing altitudes. These results indicate that the positive influence of GN [or CCN with low critical supersaturations (Sc)] on Nd is greater than the negative influence of high Sc CCN on Nd at high cloud altitudes where there are more drizzle drops. This work has implications not only for fundamental cloud physics but also for climate change; i.e., global warming and the indirect aerosol effect as well as geoengineering and hygroscopic cloud seeding.

  20. Hepatic cytomembranous inclusions in patients with type C chronic hepatitis

    Microsoft Academic Search

    Seishiro Watanabe; Mutsunori Shirai; Keiji Arima; Mikio Nishioka; Miyuki Ohbayashi; Eugene R. Schiff

    1995-01-01

    Electron microscopic studies of the liver biopsy specimens from two patients with chronic type C hepatitis revealed cytomembranous structures. Cylindrical confronting cisternae were identified for the first time in the cytoplasm of macrophages in the specimen which was taken during ?-interferon therapy. Tubuloreticular inclusions were observed in both patients with and without therapy. Although the cytomembranous inclusions are not specific

  1. Hydrodynamic Simulations of Giant Impacts

    NASA Astrophysics Data System (ADS)

    Reinhardt, Christian; Stadel, Joachim

    2013-07-01

    We studied the basic numerical aspects of giant impacts using Smoothed Particles Hydrodynamics (SPH), which has been used in most of the prior studies conducted in this area (e.g., Benz, Canup). Our main goal was to modify the massive parallel, multi-stepping code GASOLINE widely used in cosmological simulations so that it can properly simulate the behavior of condensed materials such as granite or iron using the Tillotson equation of state. GASOLINE has been used to simulate hundreds of millions of particles for ideal gas physics so that using several millions of particles in condensed material simulations seems possible. In order to focus our attention of the numerical aspects of the problem we neglected the internal structure of the protoplanets and modelled them as homogenous (isothermal) granite spheres. For the energy balance we only considered PdV work and shock heating of the material during the impact (neglected cooling of the material). Starting at a low resolution of 2048 particles for the target and the impactor we run several simulations for different impact parameters and impact velocities and successfully reproduced the main features of the pioneering work of Benz from 1986. The impact sends a shock wave through both bodies heating the target and disrupting the remaining impactor. As in prior simulations material is ejected from the collision. How much, and whether it leaves the system or survives in an orbit for a longer time, depends on the initial conditions but also on resolution. Increasing the resolution (to 1.2x10? particles) results in both a much clearer shock wave and deformation of the bodies during the impact and a more compact and detailed "arm" like structure of the ejected material. Currently we are investigating some numerical issues we encountered and are implementing differentiated models, making one step closer to more realistic protoplanets in such giant impact simulations.

  2. Giant virus in the sea

    PubMed Central

    Claverie, Jean-Michel

    2013-01-01

    The viral nature of the first “giant virus,” Mimivirus, was realized in 2003, 10 y after its initial isolation from the water of a cooling tower in Bradford, UK. Soon after its genome was sequenced, the mining of the Global Ocean Sampling environmental sequence database revealed that the closest relatives of Mimivirus, only known to infect Acanthamoeba, were to be found in the sea. These predicted marine Mimivirus relatives remained elusive until 2010, with the first genomic characterization of a virus infecting a heterotrophic unicellular eukaryote, the microflagellate grazer Cafeteria roenbergensis. The genome analysis of a virus (PgV) infecting the common unicellular algae Phaeocystis globosa now shows that it is a bona fide member of the Mimivirus family (i.e., the Megaviridae), extending the realm of these giant viruses to abundant blooming phytoplankton species. Despite its smaller genome size (460 kb encoding 434 proteins), PgV exhibits the most intriguing feature of the previously characterized Megaviridae: an associated virophage. However, the 19-kb virophage genome, devoid of a capsid gene, is packaged in the PgV particle and propagated as a “viral plasmid,” the first ever described. The PgV genome also exhibits the duplication of “core genes,” normally present as single copies and a putative new type of mobile element. In a DNA polymerase phylogeny including representatives of the three cellular domains, PgV and the other Megaviridae cluster into their own clade deeply branching between domains Archaea and Eukarya domains, thus exhibiting the topology of a fourth domain in the Tree of Life. PMID:24563700

  3. Pediatric knowledge about acute viral hepatitis.

    PubMed

    Franca, Rita; Silva, Luciana; Melo, Maria Clotildes; Cavalcante, Suzy; Lima, Bruno; Rocha, Anita; Gomes, Cristiana; Franca, Mônica

    2004-06-01

    Knowledge about hepatotropic viruses is crucial for pediatricians because of the high prevalence of viral hepatitis during childhood. The multiplicity of hepatotropic viruses, the spectrum of acute and chronic infections, and the sequels of viral hepatitis result in a need for physicians to better understand the clinical and epidemiological context of patients with viral hepatitis, as well as the importance of prevention measures for hepatitis. A descriptive cross-sectional study was made of pediatrician's knowledge about viral hepatitis, through questionnaires to 574 pediatricians, with no obligation of identification. The pediatricians were recruited among those who attended a national Congress of Pediatrics in Brasília, Brazil. Among these pediatricians, 50.1% frequently treated cases of hepatitis, and 74.7% indicated that they had knowledge of the existence of five hepatotropic viruses; 14.5% knew about at least four types of hepatitis complications, while only 7.7% and 4.3% were able to correctly diagnose viral hepatitis A and B, respectively. Many (28.4%) did not know how to treat the patients adequately. Only 37.5% had already recommended vaccination against hepatitis B. Only 50.2% of the pediatricians had been vaccinated against hepatitis B. We concluded that it is crucial to make pediatricians more knowledgeable about viral hepatitis, through continued education programs, especially emphasizing prevention procedures. PMID:15476061

  4. [Epidemiology of viral hepatitis in Mexico].

    PubMed

    Panduro, Arturo; Escobedo Meléndez, Griselda; Fierro, Nora A; Ruiz Madrigal, Bertha; Zepeda-Carrillo, Eloy Alfonso; Román, Sonia

    2011-01-01

    The main etiology of liver disease in Mexico is alcohol and viral hepatitis. The aim of the present study was to analyze the current epidemiology of viral hepatitis in Mexico. From 2000 to 2007 the Ministry of Health reported 192 588 cases of hepatitis, 79% HAV, 3.3% HBV, 6% HCV, and 12% without a specific etiologic factor. Due to high endemic areas for HBV infection in native Mexican population, limitations in the diagnostic sensitivity and specificity of the serological immunoassays used to date and presence of occult hepatitis B in the country, the real prevalence of HBV infection could be even higher than HCV in Mexico. Hepatitis E virus in cirrhotic patients and in porcine farms could at least partially explain the cases of hepatitis that are diagnosed without a specific etiologic agent. Specific strategies to establish control regulations against viral hepatitis infections in Mexico are proposed. PMID:21877071

  5. 8 Immunopathogenesis of hepatitis C

    Microsoft Academic Search

    Barbara Rehermann; Gabriele MISSALE; Carolina BONI; Simona URBANI

    2000-01-01

    Print this page SUMMARY The type of cell-mediated responses expressed at the early stages of HBV infection can influence the subsequent outcome of hepatitis B. Indeed, recovery is associated with efficient activation of mechanisms of the innate immunity, which seem to be responsible for the early inhibition of viral replication. A subsequent activation of HBV-specific T cells is probably crucial

  6. Treatment of chronic hepatitis B

    Microsoft Academic Search

    P. Marcellin; T. Asselah; N. Boyer

    2005-01-01

    SUMMARY. In the last years, marked progress has been made in the treatment of chronic hepatitis B. The efficacy of lami- vudine, the first nucleoside analogue available, is limited by the high incidence of resistance. Adefovir, which was recently approved has a comparable efficacy with a very low frequency of resistance. However, adefovir needs to be indefinitely administered as withdrawal

  7. HEPATIC SINUSOIDAL ENDOTHELIUM IN GOATS

    Microsoft Academic Search

    PL Wright; JA Clemett; KF Smith; WA Day; R Fraser

    1983-01-01

    The ultrastructure of the hepatic sinusoids of the goat was examined. Contrary to current belief concerning this and other ruminant species, we found the sinusoids to be lined by a smooth, continuous layer of endothelium, broken only by the presence of numerous, unoccluded fenestrae which provide a direct path of communication between the sinusoidal lumen and the space of Disse.

  8. Astroglial Dysfunction in Hepatic Encephalopathy

    Microsoft Academic Search

    Michael D. Norenberg

    1998-01-01

    While the pathogenesis of hepatic encephalopathy (HE) remains elusive, there is considerable evidence pointing to a key role of ammonia-induced dysfunction of astrocytes in this condition. Deficits in the ability of astrocytes to take up glutamate from the extracellular space may lead to abnormal glutamatergic neurotransmission. Furthermore, excessive stimulation of neuronal and glial glutamate receptors by elevated extracellular levels of

  9. "GIANT" Steps to Create Online Orientations

    ERIC Educational Resources Information Center

    Bacon, Pamela

    2005-01-01

    Online orientation is provided due to the flexibility of online learning. The online orientation consists of the GIANT steps which stands for Get support, Identify your curriculum, Assemble your program, Navigate students through the pilot project and Test students.

  10. Giant cell arteritis presenting as scalp necrosis.

    PubMed

    Maidana, Daniel E; Muñoz, Silvia; Acebes, Xènia; Llatjós, Roger; Jucglà, Anna; Alvarez, Alba

    2011-01-01

    The differential of scalp ulceration in older patients should include several causes, such as herpes zoster, irritant contact dermatitis, ulcerated skin tumors, postirradiation ulcers, microbial infections, pyoderma gangrenosum, and giant cell arteritis. Scalp necrosis associated with giant cell arteritis was first described in the 1940s. The presence of this dermatological sign within giant cell arteritis represents a severity marker of this disease, with a higher mean age at diagnosis, an elevated risk of vision loss and tongue gangrene, as well as overall higher mortality rates, in comparison to patients not presenting this manifestation. Even though scalp necrosis due to giant cell arteritis is exceptional, a high level of suspicion must be held for this clinical finding, in order to initiate prompt and proper treatment and avoid blindness. PMID:21789466

  11. EUVE Observations of the Hyades Giants

    NASA Technical Reports Server (NTRS)

    Stern, Robert A.; Oliversen, Ronald J. (Technical Monitor)

    1998-01-01

    We describe EUVE and ROSAT observations of the Hyades K0 III giants theta(sup 1) (vB 71 = HR1411) and gamma (vB 28 = HR1346) Tau. We also discuss ASCA observations of theta(sup 1)Tau. The coronal activity of these "clump" giants is intermediate between that of the Sun and of high activity stars such as RS CVn systems. There is no evidence for significant short or long term variability up to several years. Modeling of the individual and combined spectra suggest that these two X-ray and EUV-bright Hyades giants resemble in their activity levels another clump giant, beta Cet, with a peak in the emission measure distribution near log T approx. 6.8, reminiscent of the Capella emission measure "bump."

  12. EUVE Observations of the Hyades Giants

    NASA Technical Reports Server (NTRS)

    Stern, Robert A.

    1998-01-01

    The contractor describes EUVE and ROSAT observations of the Hyades K0 III giants theta(sup 1(vB 71 = HR 1411) and gamma$ (vB 28 = HR 1346) Tau, and ASCA observations of theta(sup 1) Tau. The coronal activity of these "clump" giants is intermediate between that of the Sun and of high-activity stars such as RS CVn systems. There is no evidence for significant short or long term variability up to several years. Modeling of the individual and combined spectra suggest that these two X-ray and EUV- bright Hyades giants resemble in their activity levels another clump giant, beta Cet, with a peak in the emission measure distribution near log T approx. 6.8, reminiscent of the Capella emission measure "bump."

  13. Giant planet and brown dwarf formation

    E-print Network

    Chabrier, G; Janson, M; Rafikov, R

    2014-01-01

    Understanding the dominant brown dwarf and giant planet formation processes, and finding out whether these processes rely on completely different mechanisms or share common channels represents one of the major challenges of astronomy and remains the subject of heated debates. It is the aim of this review to summarize the latest developments in this field and to address the issue of origin by confronting different brown dwarf and giant planet formation scenarios to presently available observational constraints. As examined in the review, if objects are classified as "Brown Dwarfs" or "Giant Planets" on the basis of their formation mechanism, it has now become clear that their mass domains overlap and that there is no mass limit between these two distinct populations. Furthermore, while there is increasing observational evidence for the existence of non-deuterium burning brown dwarfs, some giant planets, characterized by a significantly metal enriched composition, might be massive enough to ignite deuterium bur...

  14. Giant lipomas of the upper extremity

    PubMed Central

    Allen, Brian; Rader, Christine; Babigian, Alan

    2007-01-01

    Lipomas are slow-growing soft tissue tumours that rarely reach a size larger than 2 cm. Lesions larger than 5 cm, so-called giant lipomas, can occur anywhere in the body but are seldom found in the upper extremities. The authors present their experiences with eight patients having giant lipomas of the upper extremity. In addition, a review of the literature, and a discussion of the appropriate evaluation and management are included. PMID:19554145

  15. Models of Irradiated Extrasolar Giant Planets

    E-print Network

    Adam Burrows; David Sudarsky

    2002-07-23

    We review some of the characteristics of irradiated extrasolar giant planets (EGPs), in anticipation of their direct detection from the ground and from space. Spectral measurements are the key to unlocking their structural and atmospheric characteristics and to determining the true differences between giant planets and brown dwarfs. In this spirit, the theoretical spectral and atmospheric calculations we summarize here are in support of the many searches for EGPs to be conducted in the coming decade by astronomers from around the world.

  16. CALL TO ACTION TO SCALE UP GLOBAL HEPATITIS RESPONSE

    E-print Network

    Straight, Aaron

    hepatitis and some 2 billion have been infected with hepatitis B virus. Most people with chronic hepatitis B. Such treatments must be made accessible to people who need them at affordable prices. Hepatitis B is preventable with a safe and effective vaccine, however, there are 240 million people living with chronic hepatitis B

  17. Occult HBV Infection among Chronic Hepatitis C Patients

    Microsoft Academic Search

    Aghazadeh R; Honarkar Z; Alavian SM; Samiee Sh; Saeedfar K; Ehsani MJ; Nori Nayer B

    Transmission routs of both hepatitis B and hepatitis C viruses are similar and infection with both viruses is common. Occult hepatitis B is a new entity in which serum HBsAg is negative but HBVDNA is detectable in serum or liver tissues. In this study the frequency of occult hepatitis B among patients with chronic hepatitis C and also their biochemical

  18. Hepatitis A: Old and New

    PubMed Central

    Cuthbert, Jennifer A.

    2001-01-01

    The hepatitis A virus (HAV), a picornavirus, is a common cause of hepatitis worldwide. Spread of infection is generally person to person or by oral intake after fecal contamination of skin or mucous membranes; less commonly, there is fecal contamination of food or water. Hepatitis A is endemic in developing countries, and most residents are exposed in childhood. In contrast, the adult population in developed countries demonstrates falling rates of exposure with improvements in hygiene and sanitation. The export of food that cannot be sterilized, from countries of high endemicity to areas with low rates of infection, is a potentially important source of infection. After ingestion and uptake from the gastrointestinal tract, the virus replicates in the liver and is excreted into the bile. Cellular immune responses to the virus lead to destruction of infected hepatocytes with consequent development of symptoms and signs of disease. Humoral immune responses are the basis for diagnostic serologic assays. Acute HAV infection is clinically indistinguishable from other causes of acute viral hepatitis. In young children the disease is often asymptomatic, whereas in older children and adults there may be a range of clinical manifestations from mild, anicteric infection to fulminant hepatic failure. Clinical variants include prolonged, relapsing, and cholestatic forms. Management of the acute illness is supportive, and complete recovery without sequelae is the usual outcome. Research efforts during World War II led to the development of passive immunoprophylaxis. Pooled immune serum globulin is efficacious in the prevention and attenuation of disease in exposed individuals. More recently, active immunoprophylaxis by vaccination has been accomplished. Future eradication of this disease can now be contemplated. PMID:11148002

  19. Eltrombopag in chronic hepatitis C

    PubMed Central

    Mih?il?, Romeo-Gabriel; Cip?ian, Remus-C?lin

    2014-01-01

    Chronic hepatitis C is a public health problem worldwide. Unfortunately, not all patients may benefit from antiviral therapy due to thrombocytopenia. Its causes are represented by portal hypertension and platelet sequestration in the spleen, decreased serum levels or activity of thrombopoietin, the bone marrow suppression induced by hepatitis C virus and a possible adverse effect of interferon. Thrombopoietin receptor analogs may contribute to increase platelet counts in these patients. Eltrombopag binds to another region of the thrombopoietin receptor compared to endogenous thrombopoietin and stimulates the proliferation and maturation of megakaryocytes and the platelet production in a dose-dependent manner. Eltrombopag has proven its effectiveness for the treatment of patients with primary immune thrombocytopenia. Its indication for other hemopathies or situations (like thrombocytopenia secondary to chemo- or radiotherapy, acute leukemia, myelodysplastic syndroms, acquired and hereditary bone marrow failure, and platelet donors) is under study. Eltrombopag may be particularly useful in patients with advanced chronic hepatitis or liver cirrhosis who require antiviral treatment. We present a minireview on the results of treatment with eltrombopag in patients chronically infected with hepatitis C virus, highlighting the benefits and mentioning possible adverse effects. In some studies eltrombopag increased the number of virological responses after clasical antiviral treatment of patients with chronic hepatitis C and reduced the transfusional requirements of those who had to be subjected to invasive surgery. Eltrombopag is a solution for many of these patients, which allows them receiving antiviral therapy and sometimes getting a sustained virological response, but they must be well monitored to prevent possible thromboembolic or bone marrow complications or liver failure occurrence. PMID:25253952

  20. Hepatic focal nodular hyperplasia in children: Imaging features on multi-slice computed tomography

    PubMed Central

    Liu, Qing-Yu; Zhang, Wei-Dong; Lai, Dong-Ming; Ou-yang, Ying; Gao, Ming; Lin, Xiao-Feng

    2012-01-01

    AIM: To retrospectively analyze the imaging features of hepatic focal nodular hyperplasia (FNH) in children on dynamic contrast-enhanced multi-slice computed tomography (MSCT) and computed tomography angiography (CTA) images. METHODS: From September 1999 to April 2012, a total of 218 cases of hepatic FNH were confirmed by either surgical resection or biopsy in the Sun Yat-sen Memorial Hospital of Sun Yat-sen University and the Cancer center of Sun Yat-sen University, including 12 cases (5.5%) of FNH in children (age ? 18 years old). All the 12 pediatric patients underwent MSCT. We retrospectively analyzed the imaging features of FNH lesions, including the number, location, size, margin, density of FNH demonstrated on pre-contrast and contrast-enhanced computed tomography (CT) scanning, central scar, fibrous septa, pseudocapsule, the morphology of the feeding arteries and the presence of draining vessels (portal vein or hepatic vein). RESULTS: All the 12 pediatric cases of FNH had solitary lesion. The maximum diameter of the lesions was 4.0-12.9 cm, with an average diameter of 5.5 ± 2.5 cm. The majority of the FNH lesions (10/12, 83.3%) had well-defined margins. Central scar (10/12, 83.3%) and fibrous septa (11/12, 91.7%) were commonly found in children with FNH. Central scar was either isodense (n = 7) or hypodense (n = 3) on pre-contrast CT images and showed progressive enhancement in 8 cases in the equilibrium phase. Fibrous septa were linear hypodense areas in the arterial phase and isodense in the portal and equilibrium phases. Pseudocapsule was very rare (1/12, 8.3%) in pediatric FNH. With the exception of central scars and fibrous septa within the lesions, all 12 cases of pediatric FNH were homogenously enhanced on the contrast-enhanced CT images, significantly hyperdense in the arterial phase (12/12, 100.0%), and isodense in the portal venous phase (7/12, 58.3%) and equilibrium phase (11/12, 91.7%). Central feeding arteries inside the tumors were observed on CTA images for all 12 cases of FNH, whereas no neovascularization of malignant tumors was noted. In 9 cases (75.0%), there was a spoke-wheel shaped centrifugal blood supply inside the tumors. The draining hepatic vein was detected in 8 cases of pediatric FNH. However, the draining vessels in the other 4 cases could not be detected. No associated hepatic adenoma or hemangioma was observed in the livers of the 12 pediatric cases. CONCLUSION: The characteristic imaging appearances of MSCT and CTA may reflect the pathological and hemodynamic features of pediatric FNH. Dynamic multi-phase MSCT and CTA imaging is an effective method for diagnosing FNH in children. PMID:23323007

  1. Guide to Understanding Hemangiomas

    MedlinePLUS

    ... growing) stage. Another is where excessive bleeding, facial nerve injury and a signi?cant surgical scar may be reasons not to have early surgery. Surgery during the early to mid involutional (shrinking) ...

  2. Oxymatrine liposome attenuates hepatic fibrosis via targeting hepatic stellate cells

    PubMed Central

    Chai, Ning-Li; Fu, Qiang; Shi, Hui; Cai, Chang-Hao; Wan, Jun; Xu, Shi-Ping; Wu, Ben-Yan

    2012-01-01

    AIM: To investigate the potential mechanism of Arg-Gly-Asp (RGD) peptide-labeled liposome loading oxymatrine (OM) therapy in CCl4-induced hepatic fibrosis in rats. METHODS: We constructed a rat model of CCl4-induced hepatic fibrosis and treated the rats with different formulations of OM. To evaluate the antifibrotic effect of OM, we detected levels of alkaline phosphatase, hepatic histopathology (hematoxylin and eosin stain and Masson staining) and fibrosis-related gene expression of matrix metallopeptidase (MMP)-2, tissue inhibitor of metalloproteinase (TIMP)-1 as well as type?I?procollagen via quantitative real-time polymerase chain reaction. To detect cell viability and apoptosis of hepatic stellate cells (HSCs), we performed 3-(4,5)-dimethylthiahiazo(-z-y1)-3,5-diphenytetrazoliumromide assay and flow cytometry. To reinforce the combination of oxymatrine with HSCs, we constructed fluorescein-isothiocyanate-conjugated Arg-Gly-Asp peptide-labeled liposomes loading OM, and its targeting of HSCs was examined by fluorescent microscopy. RESULTS: OM attenuated CCl4-induced hepatic fibrosis, as defined by reducing serum alkaline phosphatase (344.47 ± 27.52 U/L vs 550.69 ± 43.78 U/L, P < 0.05), attenuating liver injury and improving collagen deposits (2.36% ± 0.09% vs 7.70% ± 0.60%, P < 0.05) and downregulating fibrosis-related gene expression, that is, MMP-2, TIMP-1 and type?I?procollagen (P < 0.05). OM inhibited cell viability and induced apoptosis of HSCs in vitro. RGD promoted OM targeting of HSCs and enhanced the therapeutic effect of OM in terms of serum alkaline phosphatase (272.51 ± 19.55 U/L vs 344.47 ± 27.52 U/L, P < 0.05), liver injury, collagen deposits (0.26% ± 0.09% vs 2.36% ± 0.09%, P < 0.05) and downregulating fibrosis-related gene expression, that is, MMP-2, TIMP-1 and type?I?procollagen (P < 0.05). Moreover, in vitro assay demonstrated that RGD enhanced the effect of OM on HSC viability and apoptosis. CONCLUSION: OM attenuated hepatic fibrosis by inhibiting viability and inducing apoptosis of HSCs. The RGD-labeled formulation enhanced the targeting efficiency for HSCs and the therapeutic effect. PMID:22919254

  3. Epidemiology of Hepatitis B, C, E, and G Virus Infections and Molecular Analysis of Hepatitis G Virus Isolates in Bolivia

    Microsoft Academic Search

    NAMI KONOMI; CHIAKI MIYOSHI; CARLOS LA FUENTE ZERAIN; TIAN-CHENG LI; YASUYUKI ARAKAWA; KENJI ABE

    1999-01-01

    Prevalence of hepatitis B virus (HBV), hepatitis C virus (HCV), hepatitis G virus (HGV), and hepatitis E virus (HEV) was investigated among 574 healthy blood donors in Bolivia. HCV RNA and HGV RNA in the serum were identified by a nested reverse transcription-PCR using primers derived from the 5* untranslated region (5* UTR). We also tested for hepatitis B surface

  4. Hepatitis B antigen, hepatitis B antibody, and subtypes in leprosy.

    PubMed Central

    Sher, R; Mackay, M E; Macnab, G M; Kok, S H; Koornhof, H J

    1977-01-01

    The prevalence of hepatitis B antigen (HBsAg), hepatitis B antibody (HBsAb), and subtypes in 242 cases of leprosy is reported. Patients were divided into three subgroups, lepromatous (174), tuberculoid (55), and borderline (13). A total of 131 patients were tested on admission; the remaining 111 had been institutionalized for a period of 3 months or more when tested. Of the 131 cases tested on admission, 88 were retested 6 to 12 months after admission. There was no statistical difference in the incidence of HBsAg and HBsAb among the three groups or between normal controls and the leprosy patients. The predominant subtype was ADW (84.1%). After institutionalization, one lepromatous case converted to HBsAg positive and four converted to HBsAb positive. PMID:885608

  5. With the help of giants.

    PubMed

    Fridovich, Irwin

    2003-01-01

    A childhood fascination with animals, plants, and insects was aided and abetted by many giants, beginning with my parents. The Bronx High School of Science and the City College of New York (CCNY) made a solid and priceless grounding in chemistry and biology available free of charge. Abe Mazur at CCNY revealed the wonders of biochemistry and illustrated that it was possible to pursue these wonders while being paid to do so. He also directed me to Duke University Medical School for PhD work under the tutelage of Phil Handler. With the exception of a sabbatical year at Harvard with Frank Westheimer, my entire career has been spent at Duke serving under three fine and supportive chairmen: Handler, Hill, and Raetz. The premier discoveries to emanate from my laboratory have been the sulfite oxidase, the several superoxide dismutases, the manganese catalase, and the catalase/peroxidase. Many other topics piqued my interest and resulted in ~ 400 publications. Herein I have recounted some of the circumstances surrounding that work and named a few of the people involved. The first 20 years I worked happily at the bench and the next 35 years just as happily facilitating the work of younger people. It has been so rewarding that I wish for nothing more than to be allowed to keep at it. PMID:14527320

  6. Giant electrocaloric effect around Tc.

    PubMed

    Rose, Maimon C; Cohen, R E

    2012-11-01

    We use molecular dynamics with a first-principles-based shell model potential to study the electrocaloric effect (ECE) in lithium niobate, LiNbO(3), and find a giant electrocaloric effect along a line passing through the ferroelectric transition. With an applied electric field, a line of maximum ECE passes through the zero field ferroelectric transition, continuing along a Widom line at high temperatures with increasing fields, and along the instability that leads to homogeneous ferroelectric switching below T(c) with an applied field antiparallel to the spontaneous polarization. This line is defined as the minimum in the inverse capacitance under an applied electric field. We investigate the effects of pressure, temperature and an applied electric field on the ECE. The behavior we observe in LiNbO(3) should generally apply to ferroelectrics; we therefore suggest that the operating temperature for refrigeration and energy scavenging applications should be above the ferroelectric transition region to obtain a large electrocaloric response. The relationship between T(c), the Widom line, and homogeneous switching should be universal among ferroelectrics, relaxors, multiferroics, and the same behavior should be found under applied magnetic fields in ferromagnets. PMID:23215332

  7. The Giant Planet Satellite Exospheres

    NASA Technical Reports Server (NTRS)

    McGrath, Melissa A.

    2014-01-01

    Exospheres are relatively common in the outer solar system among the moons of the gas giant planets. They span the range from very tenuous, surface-bounded exospheres (e.g., Rhea, Dione) to quite robust exospheres with exobase above the surface (e.g., lo, Triton), and include many intermediate cases (e.g., Europa, Ganymede, Enceladus). The exospheres of these moons exhibit an interesting variety of sources, from surface sputtering, to frost sublimation, to active plumes, and also well illustrate another common characteristic of the outer planet satellite exospheres, namely, that the primary species often exists both as a gas in atmosphere, and a condensate (frost or ice) on the surface. As described by Yelle et al. (1995) for Triton, "The interchange of matter between gas and solid phases on these bodies has profound effects on the physical state of the surface and the structure of the atmosphere." A brief overview of the exospheres of the outer planet satellites will be presented, including an inter-comparison of these satellites exospheres with each other, and with the exospheres of the Moon and Mercury.

  8. Giant Bubble Pinch-Off

    NASA Astrophysics Data System (ADS)

    Bergmann, Raymond; van der Meer, Devaraj; Stijnman, Mark; Sandtke, Marijn; Prosperetti, Andrea; Lohse, Detlef

    2006-04-01

    Self-similarity has been the paradigmatic picture for the pinch-off of a drop. Here we will show through high-speed imaging and boundary integral simulations that the inverse problem, the pinch-off of an air bubble in water, is not self-similar in a strict sense: A disk is quickly pulled through a water surface, leading to a giant, cylindrical void which after collapse creates an upward and a downward jet. Only in the limiting case of large Froude numbers does the purely inertial scaling h(-log?h)1/4??1/2 for the neck radius h [J. M. Gordillo , Phys. Rev. Lett.PRLTAO0031-9007 95, 194501 (2005)] become visible. For any finite Froude number the collapse is slower, and a second length scale, the curvature of the void, comes into play. Both length scales are found to exhibit power-law scaling in time, but with different exponents depending on the Froude number, signaling the nonuniversality of the bubble pinch-off.

  9. Electrodynamics on extrasolar giant planets

    E-print Network

    Koskinen, T T; Lavvas, P; Cho, J Y-K

    2014-01-01

    Strong ionization on close-in extrasolar giant planets suggests that their atmospheres may be affected by ion drag and resistive heating arising from wind-driven electrodynamics. Recent models of ion drag on these planets, however, are based on thermal ionization only and do not include the upper atmosphere above the 1 mbar level. These models are also based on simplified equations of resistive MHD that are not always valid in extrasolar planet atmospheres. We show that photoionization dominates over thermal ionization over much of the dayside atmosphere above the 100 mbar level, creating an upper ionosphere dominated by ionization of H and He and a lower ionosphere dominated by ionization of metals such as Na, K, and Mg. The resulting dayside electron densities on close-in exoplanets are higher than those encountered in any planetary ionosphere of the solar system, and the conductivities are comparable to the chromosphere of the Sun. Based on these results and assumed magnetic fields, we constrain the conduc...

  10. Imaging in Giant Cell Arteritis.

    PubMed

    Khan, Asad; Dasgupta, Bhaskar

    2015-08-01

    Much progress has been made in the use of imaging as a diagnostic tool in giant cell arteritis (GCA), which assists in the management of patients where the initial diagnosis is unclear. This includes patients with atypical cranial symptoms, or with predominantly systemic, constitutional or limb symptoms. Ultrasound and magnetic resonance imaging are capable of visualising both the cranial and extracranial large vessel circulation, with vessel wall thickening and stenotic lesions being visualised. Computed tomographic angiography is helpful in visualising the aorta for aneurysm complicating GCA but can also detect vessel wall thickening in established large vessel vasculitis. PET-CT is a very sensitive test for early vascular inflammation in extracranial large vessel vasculitis, before aneurysmal or stenotic lesions have developed, of use in the patient with unexplained constitutional symptoms. The place of imaging in the follow-up of GCA is being investigated, and repeated imaging may be useful in select cases. Generally, vascular abnormalities become less defined once glucocorticoid treatment has been started, and therefore, imaging studies must be conducted early as part of a GCA fast-track assessment. PMID:26113013

  11. Hepatitis B Shots Are Recommended for All New Babies

    MedlinePLUS

    ... can be prevented by vaccination. Who recommends that all babies get hepatitis B vaccination at birth? Medical ... B virus. Hepatitis B Shots Are Recommended for All New Babies. Hepatitis B Vaccine Helps Protect Your ...

  12. 21 CFR 660.40 - Hepatitis B Surface Antigen.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ...2013-04-01 2013-04-01 false Hepatitis B Surface Antigen. 660.40 Section...DIAGNOSTIC SUBSTANCES FOR LABORATORY TESTS Hepatitis B Surface Antigen § 660.40 Hepatitis B Surface Antigen. (a) Proper name...

  13. 65 FR 53316 - Interim Hepatitis B Vaccine Information Materials

    Federal Register 2010, 2011, 2012, 2013, 2014

    2000-09-01

    ...Disease Control and Prevention Interim Hepatitis B Vaccine Information Materials AGENCY...SUMMARY: A hepatitis B vaccine has recently been approved...information statement entitled, ``Hepatitis B Vaccine: What You Need to...

  14. Hepatitis B vaccine - what you need to know

    MedlinePLUS

    ... is taken in its entirety from the CDC Hepatitis B Vaccine Information Statement (VIS): http://www.cdc.gov/vaccines/ ... injecting drugs Being stuck with a used needle Hepatitis B vaccine: Why get vaccinated? Hepatitis B vaccine can prevent ...

  15. 21 CFR 660.40 - Hepatitis B Surface Antigen.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...2010-04-01 2010-04-01 false Hepatitis B Surface Antigen. 660.40 Section...DIAGNOSTIC SUBSTANCES FOR LABORATORY TESTS Hepatitis B Surface Antigen § 660.40 Hepatitis B Surface Antigen. (a) Proper name...

  16. 21 CFR 660.40 - Hepatitis B Surface Antigen.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 2011-04-01 2010-04-01 true Hepatitis B Surface Antigen. 660.40 Section...DIAGNOSTIC SUBSTANCES FOR LABORATORY TESTS Hepatitis B Surface Antigen § 660.40 Hepatitis B Surface Antigen. (a) Proper name...

  17. 21 CFR 660.40 - Hepatitis B Surface Antigen.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...2012-04-01 2012-04-01 false Hepatitis B Surface Antigen. 660.40 Section...DIAGNOSTIC SUBSTANCES FOR LABORATORY TESTS Hepatitis B Surface Antigen § 660.40 Hepatitis B Surface Antigen. (a) Proper name...

  18. 21 CFR 660.40 - Hepatitis B Surface Antigen.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ...2014-04-01 2014-04-01 false Hepatitis B Surface Antigen. 660.40 Section...DIAGNOSTIC SUBSTANCES FOR LABORATORY TESTS Hepatitis B Surface Antigen § 660.40 Hepatitis B Surface Antigen. (a) Proper name...

  19. Occult hepatitis B virus infection in Lebanese patients with chronic hepatitis C liver disease

    Microsoft Academic Search

    S. Ramia; A. I. Sharara; M. El-Zaatari; F. Ramlawi; Z. Mahfoud

    2008-01-01

    Occult hepatitis B virus (HBV) infection, characterised by the presence of HBV infection with undetectable hepatitis B surface\\u000a antigen (HBsAg), was investigated in 98 Lebanese patients with chronic hepatitis C liver disease and 85 control subjects recruited\\u000a from eight institutions in different parts of the country. The prevalence of occult HBV infection ranged from 11.9% to 44.4%\\u000a in hepatitis C

  20. Osteoclastic giant cell tumor of the pancreas?

    PubMed Central

    Temesgen, Wudneh M.; Wachtel, Mitchell; Dissanaike, Sharmila

    2014-01-01

    INTRODUCTION Pancreatic giant cell tumors are rare, with an incidence of less than 1% of all pancreatic tumors. Osteoclastic giant cell tumor (OGCT) of the pancreas is one of the three types of PGCT, which are now classified as undifferentiated carcinoma with osteoclast-like giant cells. PRESENTATION OF CASE The patient is a 57 year old woman who presented with a 3 week history of epigastric pain and a palpable abdominal mass. Imaging studies revealed an 18 cm × 15 cm soft tissue mass with cystic components which involved the pancreas, stomach and spleen. Exploratory laparotomy with distal pancreatectomy, partial gastrectomy and splenectomy was performed. Histology revealed undifferentiated pancreatic carcinoma with osteoclast-like giant cells with production of osteoid and glandular elements. DISCUSSION OGCT of the pancreas resembles benign-appearing giant cell tumors of bone, and contain osteoclastic-like multinucleated cells and mononuclear cells. OGCTs display a less aggressive course with slow metastasis and lymph node spread compared to pancreatic adenocarcinoma. Due to the rarity of the cancer, there is a lack of prospective studies on treatment options. Surgical en-bloc resection is currently considered first line treatment. The role of adjuvant therapy with radiotherapy or chemotherapy has not been established. CONCLUSION Pancreatic giant cell tumors are rare pancreatic neoplasms with unique clinical and pathological characteristics. Osteoclastic giant cell tumors are the most favorable sub-type. Surgical en bloc resection is the first line treatment. Long-term follow-up of patients with these tumors is essential to compile a body of literature to help guide treatment. PMID:24631915