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1

Arterial Embolization of Giant Hepatic Hemangiomas  

SciTech Connect

Hepatic cavernous hemangiomas are usually small and asymptomatic. They are usually discovered incidentally and only a few require treatment. However, giant hemangiomas may cause symptoms,which are indications for treatment. We describe four cases of symptomatic giant hepatic hemangiomas successfully treated with transcatheter arterial embolization, performed with polyvinyl alcohol particles. There were no complications. Follow-up with clinical and imaging examinations showed disappearance of symptoms and decrease in size of lesions.

Giavroglou, Constantinos; Economou, Hippolete; Ioannidis, Ioannis [Department of Radiology, AHEPA Hospital, Aristotle University of Thessaloniki (Greece)

2003-02-15

2

Adult Kasabach-Merritt Syndrome due to Hepatic Giant Hemangioma  

PubMed Central

Cavernous hemangiomas are the most common benign tumors of the liver. They can reach enormous sizes and cause various complications. Kasabach-Merritt syndrome is a rare but serious complication characterized by consumptive coagulopathy caused by the hemangioma; mortality rate ranges between 10 and 37%. More than 80% of cases occur within the first year of life. Goals of the treatment are to control the coagulopathyand thrombocytopenia as well as to eradicate the hemangioma. Different nonsurgical treatment regimens are performed, includingsystemic corticosteroids, irradiation and various chemicals. Surgery should be limited to symptomatic or complicated cases. Although difficult, resection of the tumor is usually curative. Here we present a 44-year-old woman with giant hepatic hemangioma causing Kasabach-Merritt syndrome managed by enucleation. PMID:21103246

Aslan, Ahmet; Meyer zu Vilsendorf, Andreas; Kleine, Moritz; Bredt, Martin; Bektas, Hüseyin

2009-01-01

3

Right hepatectomy for giant cavernous hemangioma with diffuse hemangiomatosis around Glisson’s capsule  

PubMed Central

Diffuse liver hemangiomatosis with giant cavernous hemangioma in adult is extremely rare. A 35 year-old woman presented to hospital with main complaint of epigastric pain and abdominal fullness. An enhanced computed tomography scan revealed a massive liver tumor in right lobe about 150 mm in size. There was contrast enhancement at the periphery of the mass consistent with a cavernous hemangioma. She underwent right hepatectomy. Histologically, it was diagnosed as a cavernous hemangioma. And also, hemangiomatous lesions were scattered around the Glisson’s capsule on the back ground liver. These hemangiomatous lesions were not recognized preoperatively. Even if we couldn’t diagnose hemangiomatosis around the main giant hemangioma preoperatively, we need to take enough surgical margins because the giant hemangioma has the potential to have small hemangiomatous lesions around the tumor. We reported right hepatectomy for giant cavernous hemangioma with diffuse hepatic hemangiomatosis without an extrahepatic lesion in an adult. PMID:25009410

Ohkura, Yu; Hashimoto, Masaji; Lee, Seigi; Sasaki, Kazunari; Matsuda, Masamichi; Watanabe, Goro

2014-01-01

4

Spontaneous rupture of hepatic hemangiomas: A review of the literature.  

PubMed

Hepatic hemangiomas are congenital vascular malformations, considered the most common benign mesenchymal hepatic tumors, composed of masses of blood vessels that are atypical or irregular in arrangement and size. Hepatic hemangiomas can be divided into two major groups: capillary hemangiomas and cavernous hemangiomas These tumors most frequently affect females (80%) and adults in their fourth and fifth decades of life. Most cases are asymptomatic although a few patients may present with a wide variety of clinical symptoms, with spontaneous or traumatic rupture being the most severe complication. In cases of spontaneous rupture, clinical manifestations consist of sudden abdominal pain, and anemia secondary to a haemoperitoneum. Disseminated intravascular coagulopathy can also occur. Haemodynamic instability and signs of hypovolemic shock appear in about one third of cases. As the size of the hemangioma increases, so does the chance of rupture. Imaging studies used in the diagnosis of hepatic hemangiomas include ultrasonography, dynamic contrast-enchanced computed tomography scanning, magnetic resonance imaging, hepatic arteriography, digital subtraction angiography, and nuclear medicine studies. In most cases hepatic hemangiomas are asymptomatic and should be followed up by means of periodic radiological examination. Surgery should be restricted to specific situations. Absolute indications for surgery are spontaneous or traumatic rupture with hemoperitoneum, intratumoral bleeding and consumptive coagulopathy (Kassabach-Merrit syndrome). In a patient presenting with acute abdominal pain due to unknown abdominal disease, spontaneous rupture of a hepatic tumor such as a hemangioma should be considered as a rare differential diagnosis. PMID:21191518

Jr, Marcelo Af Ribeiro; Papaiordanou, Francine; Gonçalves, Juliana M; Chaib, Eleazar

2010-12-27

5

Spontaneous rupture of hepatic hemangiomas: A review of the literature  

PubMed Central

Hepatic hemangiomas are congenital vascular malformations, considered the most common benign mesenchymal hepatic tumors, composed of masses of blood vessels that are atypical or irregular in arrangement and size. Hepatic hemangiomas can be divided into two major groups: capillary hemangiomas and cavernous hemangiomas These tumors most frequently affect females (80%) and adults in their fourth and fifth decades of life. Most cases are asymptomatic although a few patients may present with a wide variety of clinical symptoms, with spontaneous or traumatic rupture being the most severe complication. In cases of spontaneous rupture, clinical manifestations consist of sudden abdominal pain, and anemia secondary to a haemoperitoneum. Disseminated intravascular coagulopathy can also occur. Haemodynamic instability and signs of hypovolemic shock appear in about one third of cases. As the size of the hemangioma increases, so does the chance of rupture. Imaging studies used in the diagnosis of hepatic hemangiomas include ultrasonography, dynamic contrast-enchanced computed tomography scanning, magnetic resonance imaging, hepatic arteriography, digital subtraction angiography, and nuclear medicine studies. In most cases hepatic hemangiomas are asymptomatic and should be followed up by means of periodic radiological examination. Surgery should be restricted to specific situations. Absolute indications for surgery are spontaneous or traumatic rupture with hemoperitoneum, intratumoral bleeding and consumptive coagulopathy (Kassabach-Merrit syndrome). In a patient presenting with acute abdominal pain due to unknown abdominal disease, spontaneous rupture of a hepatic tumor such as a hemangioma should be considered as a rare differential diagnosis. PMID:21191518

Jr, Marcelo AF Ribeiro; Papaiordanou, Francine; Gonçalves, Juliana M; Chaib, Eleazar

2010-01-01

6

Interventional Treatment of a Symptomatic Neonatal Hepatic Cavernous Hemangioma Using the Amplatzer Vascular Plug  

Microsoft Academic Search

Percutaneous intervention is one treatment option for symptomatic hepatic hemangioma in infants. We report the case of a newborn (birth weight 4060 g) with a large hepatic cavernous hemangioma, which presented early with high cardiac output failure due to arteriovenous shunting and signs of incipient Kasabach-Merritt syndrome. We performed a successful superselective transcatheter coil embolization of three feeding arteries on

Oliver Kretschmar; Walter Knirsch; Vera Bernet

2008-01-01

7

Interventional Treatment of a Symptomatic Neonatal Hepatic Cavernous Hemangioma Using the Amplatzer Vascular Plug  

Microsoft Academic Search

Percutaneous intervention is one treatment option for symptomatic hepatic hemangioma in infants. We report the case of a newborn\\u000a (birth weight 4060 g) with a large hepatic cavernous hemangioma, which presented early with high cardiac output failure due\\u000a to arteriovenous shunting and signs of incipient Kasabach-Merritt syndrome. We performed a successful superselective transcatheter\\u000a coil embolization of three feeding arteries on

Oliver Kretschmar; Walter Knirsch; Vera Bernet

2008-01-01

8

What is changing in indications and treatment of hepatic hemangiomas. A review.  

PubMed

Hepatic cavernous hemangioma accounts for 73% of all benign liver tumors with a frequency of 0.4-7.3% at autopsy and is the second most common tumor seen in the liver after metastases. Patients affected by hemangioma usually have their tumor diagnosed by ultrasound abdominal examination for a not well defined pain, but pain persist after treatment of the hemangioma. The causes of pain can be various gastrointestinal pathologies including cholelithiasis and peptic ulcer disease.The malignant trasformation is practically inexistent. Different imaging modalities are used to diagnosis liver hemangioma including ultrasonography, computed tomography (CT), magnetic resonance (MR) imaging, and less frequently scintigraphy, positronemission tomography combined with CT (PET/CT) and angiography. Imaging-guided biopsy of hemangioma is usually not resorted to except in extremely atypical cases. The right indications for surgery remain rupture, intratumoral bleeding, Kasabach-Merritt syndrome and organ or vessels compression (gastric outlet obstruction, Budd-Chiari syndrome, etc.) represents the valid indication for surgery and at the same time they are all complications of the tumor itself. The size of the tumor do not represent a valid indication for treatment. Liver hemangiomas, when indication exist, have to be treated firstly by surgery (hepatic resection or enucleation, open, laproscopic or robotic), but in the recent years other therapies like liver transplantation, radiofrequency ablation, radiotherapy, trans-arterial embolization, and chemotherapy have been applied. PMID:24927603

Toro, Adriana; Mahfouz, Ahmed-Emad; Ardiri, Annalisa; Malaguarnera, Michele; Malaguarnera, Giulia; Loria, Francesco; Bertino, Gaetano; Di Carlo, Isidoro

2014-01-01

9

[Giant cell hepatitis in adults].  

PubMed

Differential diagnosis of progressive cholestatic liver disease includes postinfantile giant-cell hepatitis, particularly in cases with negative serology for hepatitis viruses and in the absence of an intake of potentially hepatotoxic drugs. Diagnosis is made by the histologic demonstration of syncytial giant cells in liver. To the knowledge of the authors, some 70 cases have been published so far; however, the true prevalence of the disease appears to be much higher than commonly assumed. Hepatocellular giant cells, the only diagnostic marker, may be expressed in low copy numbers, and many cases thus easily escape recognition. Some 50% of the published cases are positive for autoantibodies in serum or combined with other features of autoimmunity. A correct diagnosis is important in view of the unfavorable prognosis with a rapidly progressive course in about half the cases. Fulminant liver failure and late cirrhotic stages are candidates for liver transplantation. After transplantation no recurrence of giant-cell hepatitis has been observed. Cases positive for autoantibodies have been successfully treated with corticosteroids; cholestatic forms appear to respond to ursodeoxycholic acid. Etiology of the disease is not settled. Some authors claim aberrant immunoreactivity from various causes to be responsible for the disease, others have presented evidence in favor of a paramyxovirus infection. In any case of cholestasis of unknown origin, serology for paramyxoviruses and a liver biopsy are recommended. PMID:7973279

Bianchi, L; Terracciano, L M

1994-11-01

10

Interventional treatment of a symptomatic neonatal hepatic cavernous hemangioma using the Amplatzer vascular plug.  

PubMed

Percutaneous intervention is one treatment option for symptomatic hepatic hemangioma in infants. We report the case of a newborn (birth weight 4060 g) with a large hepatic cavernous hemangioma, which presented early with high cardiac output failure due to arteriovenous shunting and signs of incipient Kasabach-Merritt syndrome. We performed a successful superselective transcatheter coil embolization of three feeding arteries on the seventh day of life. Because of remaining diffuse very small arteries causing a relevant residual shunt, additional occlusion of the three main draining veins was necessary with three Amplatzer vascular plugs. Cardiac failure resolved immediately. Without any additional therapy the large venous cavities disappeared within the following months. The tumor continues to regress in size 8 months after the intervention. PMID:17031730

Kretschmar, Oliver; Knirsch, Walter; Bernet, Vera

2008-01-01

11

Living donor liver transplantation for multiple intrahepatic portosystemic shunts after involution of infantile hepatic hemangiomas.  

PubMed

We describe a 6-year-old girl presenting with multiple intrahepatic portosystemic shunts after the involution of infantile hepatic hemangiomas (IHHs), who successfully underwent living donor liver transplantation. The chronological changes of radiologic findings indicated that remnant portovenous shunts at the time of IHHs involution developed gradually on the background of atrophic intrahepatic portal veins. This suggests that patients should be carefully followed up for the late onset of intrahepatic portosystemic shunts after the involution of IHHs. PMID:21683241

Sakamoto, Seisuke; Kasahara, Mureo; Shigeta, Takanobu; Fukuda, Akinari; Kakiuchi, Toshihiko; Miyasaka, Mikiko; Nosaka, Shunsuke; Nakano, Natsuko; Nakagawa, Atsuko; Horikawa, Reiko

2011-06-01

12

Adult hepatic cavernous hemangioma with highly elevated ?-fetoprotein: A case report and review of the literature  

PubMed Central

A 47-year-old male presented with a six-month history of fatigue and a four-month history of alanine and aspartate aminopherase elevation. Laboratory examination revealed that the serum ?-fetoprotein (AFP) level was 371.51 ?g/l (normal range, 0–20 ?g/l), and a computed tomography scan revealed a hypodense lesion in the left hepatic lobe. During laparotomy, a dark red-colored soft tumor (1.5×1.7 cm in diameter) was found in segment eight of the liver. Intra-operative pathology and post-operative histopathology examinations revealed that the tumor was a hepatic cavernous hemangioma. The serum AFP level was decreased to 24.45 ?g/l by the second post-operative week. The literature was searched and only three similar cases were found. A brief review of this rare disease entity was produced, which attempted to explain this appearance reasonably.

WANG, HUAN-YU; ZHANG, LIANG; WU, JIAN; ZHANG, ZI-JIAN; PENG, BAO-GANG; LIANG, LI-JIAN; ZHOU, QI

2015-01-01

13

Transcatheter Arterial Embolization of Two Symptomatic Giant Cavernous Hemangiomas of the Liver  

SciTech Connect

Cavernous hemangiomas are usually asymptomatic; however, a small percentage may cause symptoms. This case report discusses palliation by transcatheter arterial embolization with polyvinyl alcohol particles.

Althaus, Sandra; Ashdown, Boyd [Department of Radiology, Box 357115, University of Washington School of Medicine, 1959 NE Pacific Street, Seattle, WA 98195 (United States); Coldwell, Douglas [Department of Radiology, Denver General Hospital, 303 Bannock Street, Denver, CO 80204-4507 (United States); Helton, W. Scott [Department of General Surgery, University of Washington School of Medicine, 1959 NE Pacific Street, Seattle, WA 98195 (United States); Freeny, Patrick C. [Department of Radiology, Box 357115, University of Washington School of Medicine, 1959 NE Pacific Street, Seattle, WA 98195 (United States)

1996-09-15

14

Giant Chorioangioma Treated In Utero via Laser of Feeding Vessels with Subsequent Development of Multifocal Infantile Hemangiomas.  

PubMed

We report a case of a giant placental chorioangioma (15.6 cm diameter) complicated by polyhydramnios and severe fetal heart failure. Fetoscopic laser occlusion of a dominant feeding vessel was performed at 29 weeks' gestation and partial devascularization was achieved. In the 33rd week of the pregnancy, the decision was made to preemptively deliver the fetus due to persistent signs of fetal cardiac failure. After birth, the infant developed multifocal infantile hemangiomas with extracutaneous involvement. We posit that the development of infantile hemangiomas may be linked to the presence of the large chorioangioma. Further study is required to ascertain if fetal treatment of the chorioangioma may have been an exacerbating factor. PMID:24941233

Jhun, Katrina M; Nassar, Paulo; Chen, Tina S; Sardesai, Smeeta; Chmait, Ramen H

2015-02-01

15

Receiver Operating Characteristic Analysis of Diffusion-Weighted Magnetic Resonance Imaging in Differentiating Hepatic Hemangioma From Other Hypervascular Liver Lesions  

PubMed Central

Purpose To evaluate the role of diffusion-weighted imaging in differentiating between hepatic hemangiomas, both typical and atypical, and other hypervascular liver lesions. Methods Retrospective review of 182 hypervascular liver lesions in 117 patients was performed. Diffusion and contrast-enhanced magnetic resonance imaging were performed using a 1.5-T unit. Imaging protocol consisted of T2-weighted fast spin-echo images, breath-hold diffusion-weighted echo-planar images, and breath-hold unenhanced and contrast-enhanced T1-weighted 3-dimensional fat-suppressed spoiled gradient-echo images in the arterial phase (20 seconds) and portal venous phase (60 seconds). Signal intensity changes and apparent diffusion coefficient (ADC) values were evaluated for all lesions. Unpaired t test was used to compare the mean ADC values for different lesions, and statistical significance was set at P < 0.01. Receiver operating characteristic analysis was used to determine the accuracy of diffusion-weighted imaging in differentiating hemangiomas from other hypervascular liver lesions. Results Lesions included typical and atypical hemangioma (n = 38), hepatocellular carcinoma (HCC; n = 58), focal nodular hyperplasia (FNH; n = 22), and neuroendocrine tumor metastasis (NET; n = 64) with a mean tumor size of 5.3 cm. Mean ADC value for hemangioma, HCC, FNH, and NET was 2.29 × 10-3, 1.55 × 10-3, 1.65 × 10-3, and 1.43 × 10-3 mm2/s, respectively. There was a statistically significant difference in the ADC value of hemangioma compared with that of FNH (P < 0.001), HCC (P < 0.001), and NET (P < 0.001), respectively. The area under the receiver operating characteristic curve was 0.91. Conclusions Diffusion-weighted magnetic resonance imaging and ADC maps can provide rapid quantifiable information to differentiate typical and atypical hemangiomas from other hypervascular liver lesions. PMID:18830105

Vossen, Josephina A.; Buijs, Manon; Liapi, Eleni; Eng, John; Bluemke, David A.; Kamel, Ihab R.

2009-01-01

16

Hepatic Hemangioma in Celiac Patients: Data from a Large Consecutive Series  

PubMed Central

Background and Aims. Hepatic hemangioma (HH) has a widely ranging prevalence. The etiology is unclear; however, associations with autoimmune disorders have been described. We aimed at evaluating the prevalence of HH in celiac disease. Methods. Ninety-seven consecutive patients with celiac disease (18 M, 79 F, median age 41, and range 17–84 years) underwent liver ultrasound between January 2011 and 2012. The findings were compared with those of 1352 nonceliac patients (581 M, 771 F, median age 50, and range 16–94 years), without liver disease or previously detected HH, who underwent US in the same period. Results. Ultrasonographic findings consistent with HH were observed in 14 celiac patients (14.4%), a prevalence significantly higher than in controls (69 cases, 5.1%) (P = 0.0006). Subgroup analysis showed that, among women, the prevalence of HH was 16.4% in the celiac disease group (13/79) compared with 5.9% in controls (46/771) (P = 0.002). In celiac setting, HH had a median diameter of 1.3?cm and presented as a single lesion in 12 cases (86%). Conclusions. Our findings are consistent with a significantly higher prevalence of HH in celiac patients. Although mechanisms underlying this association remain unclear, autoimmune and metabolic processes, as well as alterations of gut-liver axis equilibrium, could play a role. PMID:25649925

Massironi, Sara; Branchi, Federica; Rossi, Roberta Elisa; Fraquelli, Mirella; Elli, Luca; Bardella, Maria Teresa; Cavalcoli, Federica; Conte, Dario

2015-01-01

17

Liver transplant for giant cell hepatitis with autoimmune haemolytic anaemia  

Microsoft Academic Search

Giant cell hepatitis (CGH) with autoimmune haemolytic anaemia (AHA) is a distinct entity with an aggressive course. Immunosuppression may help early disease. A case is reported of a child with GCH and AHA with early disease recurrence after liver transplantation for end stage liver disease.

Hector Vilca Melendez; Mohamed Rela; Alastair J Baker; Colin Ball; Bernard Portmann; Giorgina Mieli-Vergani; Nigel D Heaton

1997-01-01

18

Liver transplant for giant cell hepatitis with autoimmune haemolytic anaemia  

PubMed Central

?? Giant cell hepatitis (CGH) with autoimmune haemolytic anaemia (AHA) is a distinct entity with an aggressive course. Immunosuppression may help early disease. A case is reported of a child with GCH and AHA with early disease recurrence after liver transplantation for end stage liver disease. ?? PMID:9370907

Melendez, H. V.; Rela, M.; Baker, A.; Ball, C.; Portmann, B.; Mieli-Vergani, G.; Heaton, N.

1997-01-01

19

Cherry Hemangioma  

MedlinePLUS

newsletter | contact Share | Cherry Hemangioma Information for adults A A A The small, red bumps of cherry hemangiomas can be widespread and vary in size, as in this adult. As a general rule, cherry hemangiomas do not become much larger than an ...

20

Hepatic Cavernous Hemangiomas: Relationship between Speed of Intratumoral Enhancement during Dynamic MRI and Apparent Diffusion Coefficient on Diffusion-Weighted Imaging  

PubMed Central

Objective To investigate the relationships between the apparent diffusion coefficients (ADCs) on diffusion-weighted imaging (DWI) and the speed of contrast-enhancement in hepatic hemangiomas. Materials and Methods Sixty-nine hepatic hemangiomas (? 1 cm) were evaluated with DWI, by using multiple b values (b = 50, 400, 800 s/mm2), followed by a gadolinium-enhanced dynamic MRI. The lesions were classified into three groups, according to the speed of contrast-enhancement on the portal phase. ADCs were measured on the ADC map automatically, and were calculated by using the two different b values (mADC50-400 with b values = 50 and 400; mADC400-800 with b values = 400 and 800 s/mm2). Results The mean ADCs (× 10-3 mm2/s) were significantly higher in the rapid group (1.9 ± 0.44) than in the intermediate (1.7 ± 0.35, p = 0.046) or the slow groups (1.4 ± 0.34, p = 0.002). There were significant differences between the rapid and the slow groups in mADC50-400 (2.12 vs. 1.48; p = 0.008) and mADC400-800 (1.68 vs. 1.22, p = 0.010), and between the rapid and the intermediate groups in mADC50-400 (2.12 vs. 1.79, p = 0.049). Comparing mADC50-400 with mADC400-800, there was a significant difference only in the rapid group (p = 0.001). Conclusion Higher ADCs of rapidly-enhancing hemangiomas may be related to richer intralesional vascular perfusion. Also, the restricted diffusion may be attributed to the difference of structural characteristics of hemangioma. PMID:23118571

Nam, Se Jin; Park, Kae Young; Chung, Jae-Joon; Kim, Joo Hee; Kim, Ki Whang

2012-01-01

21

Capillary Hemangioma  

MedlinePLUS

... called the conjunctiva, and the eye socket or orbit. Why do capillary hemangiomas on the eyelids cause ... socket (the area around the eye called the orbit) can put pressure on the eye and result ...

22

Acute seronegative hepatitis C manifesting itself as adult giant cell hepatitis--a case report and review of literature.  

PubMed

Adult giant cell hepatitis (AGCH) is a rare event and only about 100 cases have been reported within the last 20 years. The AGCH has been observed in association with viral infection, drug reactions or autoimmune disorders but in many cases its etiology remains unclear. AGCH manifests clinically as severe form of hepatitis histologically characterized by diffuse giant cell transformation of hepatocytes. We report the case of a 39-yr-old man with acute community-acquired hepatitis without previous pathology of the liver. Laboratory data revealed slight hypergammaglobulinemia and high titer of anti-smooth-muscle antibody with negative serology of hepatotropic viruses and absence of other known causes of hepatitis. Preliminary diagnosis of autoimmune hepatitis was established, additionally confirmed by excellent clinical and biochemical improvement during corticosteroid treatment. A liver biopsy showed the typical findings of panlobular syncytial giant cell hepatitis and positive HCV-RNA both in serum and liver. The above verified the diagnosis of acute type C hepatitis manifested histologically as adult giant cell hepatitis. After three months of treatment we withdrew corticosteroids as spontaneous clearance of HCV occurred and the lack of autoantibodies in serum as well as significant improvement of liver histology was ascertained. Within 30 months of the follow-up we have not observed biochemical and immunological abnormalities and control liver biopsy has shown no signs of hepatitis. PMID:15156608

Kryczka, Wies?aw; Walewska-Zielecka, Bozena; Dutkiewicz, Ewa

2003-08-01

23

Endovascular treatment of a giant hepatic artery aneurysm with Amplatzer vascular plug.  

PubMed

Hepatic artery aneurysms are uncommon and account for 20% of visceral aneurysms. Some authors consider endovascular procedures as the first line treatment for most hepatic artery aneurysms, being the conventional surgery reserved for unstable ruptured aneurysms or if the anatomy is unsuitable for endovascular repair. In this report, we describe the endovascular treatment of a giant common hepatic artery aneurysm with an Amplatzer vascular plug. PMID:23932802

Cavalcante, Rafael Noronha; Couto, Viviane Augusto Pereira; da Fonseca, André Vinicius; de Miranda, Robson Barbosa; Costa, Agenor José Vasconcelos; Correa, João Antonio

2014-08-01

24

Hepatic vascular tumors.  

PubMed

The most common hepatic vascular tumor in the pediatric population is the infantile hepatic hemangioma. Although these lesions have a spectrum of presentations, there are three main subtypes that have been described-focal, multifocal, and diffuse. An algorithm on the workup, treatment, and follow-up of these lesions can be based on this categorization. Recent shifts in the management of hemangiomas with beta-blockers (propranolol) have also influenced the treatment of hepatic hemangiomas. This article reviews the current understanding of hepatic hemangiomas and protocols in the management of these patients. PMID:25241093

Hsi Dickie, Belinda; Fishman, Steven J; Azizkhan, Richard G

2014-08-01

25

What Is Hemangioma?  

MedlinePLUS

... Conditions > Symptoms Blurriness Dark Curtain Dark Spots Discharge Double Vision Drooping Eyelid Eye Pain Eyelash Crusting Eyelid ... hemangioma: a capillary hemangioma occurs in the outer layers of the skin. It is often called a “ ...

26

Birthmarks and Hemangiomas  

MedlinePLUS

... Hemangiomas Health Issues Listen Birthmarks & Hemangiomas Article Body Dark-Pigmented Birthmarks (Nevi or Moles) Nevi, or moles, ... so-called nevus cells, these spots are often dark brown or black. Congenital Nevi Small nevi (less ...

27

Hemobilia associated with a giant thrombosed aneurysm of the hepatic artery requiring hepatectomy.  

PubMed

Hemobilia is an unusual and potentially catastrophic cause of gastrointestinal bleeding. Although hepatic artery aneurysm is a cause of hemobilia, nontraumatic cases are infrequently reported. Herein, we describe the case of a giant hepatic artery aneurysm requiring hepatectomy because of repeated hemobilia in a patient with Marfan syndrome. A 53-year-old man presented to our hospital with sudden epigastric pain and jaundice. Abdominal computed tomography showed a giant hepatic arterial aneurysm in the porta hepatis, and emergency endoscopic retrograde cholangiography revealed hemobilia. Assuming that the aneurysm caused the hemobilia, we performed an abdominal angiogram for treatment. The study revealed a thrombosed aneurysm along with tortuous abnormal vessels in the periphery of the left hepatic artery, which appeared to surround the aneurysm. Therefore, we embolized the left hepatic artery, and immediate hemostasis was achieved. Rebleeding occurred 3 times thereafter, and each time, transarterial embolization was performed, resulting in prompt but only temporary hemostasis. Then, emergency left hemihepatectomy and resection of the aneurysm were performed. Pathologic examination of the resected specimen revealed that the aneurysm was completely thrombosed and organized; however, abnormal arterioles proliferated between the aneurysmal wall and the bile duct. The unique feature of this case was that the abnormal arterioles induced by the organized hepatic artery aneurysm, not the aneurysm itself, caused the hemobilia. PMID:25017773

Komatsu, Shohei; Iwasaki, Takeshi; Nishioka, Naritomo; Toyokawa, Akihiro; Teramura, Kazuhiro

2014-11-01

28

Propranolol for infantile hemangiomas.  

PubMed

Propranolol has been used successfully in a limited number of children with infantile hemangiomas. This multicenter retrospective study describes the efficacy and adverse effects of propranolol in infantile hemangioma. Seventy-one infants with infantile hemangiomas were treated with oral propranolol, 1 mg/kg/12 hours, for at least 12 weeks. A photograph based severity scoring assessment was performed by five observers to evaluate efficacy, utilizing a scoring system of 10 as the original infantile hemangioma before treatment and 0 as completely normal skin. The mean of the five independent measurements was used in the analysis. Propranolol was a rapid and effective treatment for infantile hemangiomas at 4 weeks (p < 0.001), at 8 weeks (p < 0.001 compared to the 4 wks value), at 12 weeks (p < 0.05 compared to the 8 wks value), and thereafter up to 32 weeks (p < 0.01 compared to the 16 wks value). The response of infantile hemangiomas to propranolol was similar regardless of sex, age at onset of treatment, type of involvement (segmental and nonsegmental), facial segments affected, special locations (eyelid, nasal tip, and parotid region), ulceration, and depth of infantile hemangiomas. Very few side effects were reported; mainly agitated sleep in 10 of 71 patients. In the series of patients in this study, oral propranolol 2 mg/kg/day was a well-tolerated and effective treatment for infantile hemangiomas. Prospective studies are needed to establish the exact role of propranolol in the treatment of infantile hemangiomas. PMID:21385205

Bagazgoitia, Lorea; Torrelo, Antonio; Gutiérrez, Juan Carlos López; Hernández-Martín, Angela; Luna, Paula; Gutiérrez, Marta; Baño, Antonio; Tamariz, Amalia; Larralde, Margarita; Alvarez, Roser; Pardo, Nuria; Baselga, Eulalia

2011-01-01

29

Unusual Severe Complication Following Transarterial Chemoembolization for Metastatic Malignant Melanoma: Giant Intrahepatic Cyst and Fatal Hepatic Failure  

SciTech Connect

We describe a 45-year-old male patient with malignant melanoma who underwent hepatic arterial chemoembolization due to liver metastases. Four months after the procedure, the patient developed a giant cystic cavity in the liver. Cytologic examination of the cystic fluid retention revealed necrotic tumor material. The fluid was drained by percutaneous catheter, but the patient developed hepatic failure. This case represents another rare complication of transarterial chemoembolization and shows that transarterial chemoembolization may have rare fatal complications.

Ataergin, Selmin, E-mail: sataergin@superonline.co [GATA (Gulhane) Faculty of Medicine Gn. Dr. Tevfik Saglam caddesi, Department of Medical Oncology and Bone Marrow Transplantation Unit (Turkey); Tasar, Mustafa [GATA (Gulhane) Faculty of Medicine, Department of Radiology (Turkey); Solchaga, Luis [Case Western Reserve University, Department of Blood and Marrow Transplant, Ireland Cancer Center, University Hospitals Case Medical Center (United States); Ozet, Ahmet; Arpaci, Fikret [GATA (Gulhane) Faculty of Medicine Gn. Dr. Tevfik Saglam caddesi, Department of Medical Oncology and Bone Marrow Transplantation Unit (Turkey)

2009-03-15

30

Giant hepatic hydatid cyst with sub-fascial extension treated by open minimally invasive surgery: a case report  

PubMed Central

Introduction Hepatic hydatid disease can be successfully treated by a variety of modalities. Case Presentation We report a case of a 60 year old male with giant hepatic hydatid disease who presented with a huge cystic mass in the upper abdomen. Diagnosis was confirmed by serology, ultrasonography and CT scan. The patient was treated successfully by open minimally invasive surgery with minimum breaching of the peritoneal cavity using a laparoscopic trocar to evacuate the cyst. Conclusion The use of a laparoscopic trocar through a small abdominal incision in selected patients with hepatic hydatid disease with subfascial extension can be a safe, minimally-invasive option of treatment PMID:18226227

Duttaroy, Dipesh D; Kacheriwala, Samir; Duttaroy, Bithika; Jagtap, Jitendra; Patel, Gunjan; Modi, Nikhil

2008-01-01

31

REMNANT LEFT LOBE TORSION CAUSING HEPATIC VENOUS OUTFLOW OBSTRUCTION AFTER HEPATIC RIGHT LOBECTOMY FOR GIANT HEPATOCELLULAR CARCINOMA: REPORT OF A CASE.  

PubMed

We report the case of a 67-year-old man with remnant left liver torsion causing acute hepatic venous outflow obstruction after right hepatectomy for giant hepatocellular carcinoma, which was successfully treated with surgery. After the primary surgery, he developed significant liver dysfunction and renal failure. Doppler ultrasonography disclosed gradual reduction of hepatic perfusion. Abdominal computed tomography revealed that the swollen remnant liver was dislocated in the right subphrenic space. After surgical repositioning of the left lobe into its anatomical position, the hepatic congestion immediately disappeared, and the hemodynamic parameters improved. The falciform and round ligaments were fixed to the anterior abdominal wall to keep the remnant liver in the anatomical position. His postoperative course was uneventful. Doppler ultrasonography was useful to assess hepatic perfusion for screening of acute hepatic venous outflow obstruction and abdominal computed tomography is definitive for diagnosis. Fixation of remnant liver may be effective for preventing hepatic venous outflow obstruction after right hepatectomy, particularly for giant tumor. PMID:25283977

Sato, Naoya; Kenjo, Akira; Tsuchiya, Takao; Anazawa, Takayuki; Haga, Junichiro; Sato, Tetsu; Muto, Makoto; Kimura, Takashi; Gotoh, Mitsukazu

2014-10-01

32

Infantile subglottic hemangioma.  

PubMed

Infantile subglottic hemangiomas are rare congenital lesions of the larynx that are difficult to manage. Our experience with 10 cases was reviewed. All patients presented with stridor at birth, or shortly after. The minimum follow-up was 6 months, with an average of 44 months. The patients were classified and treated according to the size of the hemangioma. The treatment included expectant management, systemic steroids, CO2 laser excision, and tracheostomies. Overall, eight patients were cured, one developed subglottic stenosis, and one died due to unrelated causes. We recommend that (1) patients with small lesions (< 25% of lumen) be treated expectantly, (2) patients with moderate lesions (25-60% of lumen) be treated with systemic steroids initially, and CO2 laser excision if steroids fail, and (3) patients with large lesions (> 60% of lumen) be treated with tracheostomies initially, and staged CO2 laser excision. PMID:8028072

Seikaly, H; Cuyler, J P

1994-04-01

33

A Case of Giant Hepatic Hydatid Cyst Infected with Morganella morganii and the Literature Review  

PubMed Central

Hydatid cyst disease is a common worldwide zoonosis. Most of the cysts are located in the liver. Abscess formation due to infection of the cyst is an important complication. M. morganii, a Gram-negative Bacillus, is a quite rare cause of liver abscess. A 77-year-old woman was admitted to hospital with complaints of fever, chills, nausea, vomiting, loss of appetite, and abdominal pain located in the right-upper quadrant. Her history was positive for hepatic hydatid cyst disease ten years ago. Physical examination revealed a painful mass filling the right-upper quadrant and extending down to umbilicus. Indirect hemagglutinin test for hydatid cyst was positive at a titer of 1/320. Giant liver abscess due to infected hydatid cyst was found in computed tomography scan. Surgeons performed cystectomy and cholecystectomy. Cefazoline, cefuroxime, and metronidazole were administered empirically, but all the three agents were replaced with intravenous ceftriaxone after M. morganii was isolated from the cultures of the abscess material. Clinical signs of the patient resolved at the second week of treatment, and she was discharged. PMID:23198187

Hakyemez, Ismail Necati; Sit, Mustafa; Aktas, Gulali; Tas, Tekin; Mengeloglu, F?rat Zafer; Kucukbayrak, Abdulkadir

2012-01-01

34

Treatment process for capillary hemangioma  

PubMed Central

Background Hemangiomas, usually, present at the first few months of life and are the most common benign tumor in children. There are various therapeutic methods for hemangioma. Capillary hemangioma is a type of hemangiomas. The steps of treatment of a child with capillary hemangioma in Taleghani Hospital of Gorgan, Iran, are reported. Case report In this report, it is described an 18-month-old child with capillary hemangioma on the right side of face. She was presented to the hematologic clinic of Taleghani Hospital of Gorgan. Three drugs, including prednisolon, propranolol and interferon alpha-2b (IFN-?-2b), were used for treating this patient. At the end of treatment, good results were obtained. After that, laser therapy was performed for fading the lesions. Conclusion Prescription of drug was our first choice for treating capillary hemangioma and it had a positive result without any complications. We used propranolol and IFN-?-2b for treating capillary hemangioma because of their better effect on this patient. PMID:25254092

Mirbehbahani, NB; Rashidbaghan, A

2014-01-01

35

Thoracic Extraosseous Epidural Cavernous Hemangioma  

PubMed Central

Cavernous hemangiomas were first reported in 1929 by Globus and Doshay, and are defined as benign vascular structures developed between the neural tissues occurring in the central nervous system, consisting of a dilated vascular bed. Cavernous hemangiomas comprise nearly 5-12% of all spinal vascular malformations; however, existence in the epidural space without bone involvement is rare. Only 4% of all cavernous hemangiomas (0.22/1.000.000) are purely epidural cavernous hemangiomas. In this case report, we removed a hemorrhagic thoracic mass presenting with progressive neurological deficits in a 55-year-old male patient. We found this case to be appropriate for presentation due to the rare occurrence of this type of cavernous hemangioma. PMID:25674348

Asil, Kiyasettin; Ceylan, Davut; Erdem, Sahin

2015-01-01

36

Hepatitis  

MedlinePLUS

... an important digestive liquid called bile . What Is Hepatitis? Hepatitis is an inflammation (say: in-fluh- may - ... the most common types of viral hepatitis. Continue Hepatitis A For kids, hep A is the most ...

37

A clinical observation to diagnose parotid hemangioma.  

PubMed

A clinical observation to diagnose parotid hemangioma is presented in this article. A hemangioma can be made to distend by blocking its venous outflow. If a distended hemangioma is located within the parotid gland, it stretches the parotid capsule. Thus application of pressure over parotid venous outflow causes the hemangioma to bulge, thereby stretching the parotid capsule. It makes the outline of the gland clinically apparent. This observation is useful to differentiate a hemangioma present in the parotid gland from one that is placed outside the gland like an intramuscular hemangioma of the masseter muscle or internal jugular phlebectasia. PMID:24426629

Reddi, Bhavani Rao

2013-06-01

38

Tumefactive presentation of a supratentorial cavernous hemangioma: A report of two cases  

PubMed Central

This study reports two children, including a 2-month-old infant, harboring giant cavernous hemangiomas (GCH) in the supratentorial compartment, causing raised intracranial pressure and focal deficits. Relevant demographic details, clinical presentation, and radiological findings of GCH are discussed in light of tumefactive presentation. Differential diagnoses of such radiological findings are elaborated. PMID:24470821

Mohindra, Sandeep; Sodhi, Harsimratbir Singh; Rane, Swapnil

2013-01-01

39

Large orbital hemangioma: managed with systemic propranolol.  

PubMed

Most infantile hemangiomas resolve spontaneously without any need for therapy. However some hemangiomas require treatment to preserve function (vision, feeding and breathing) or to treat complications like ulceration, bleeding and scarring. The authors present a 5-mo-old infant with large orbital hemangioma on left side completely obscuring palpebral fissure, successfully managed with oral propranolol. PMID:24271877

Puligadda, Ranjith K; Vijayalakshmi, B

2014-08-01

40

Pregnancy related symptomatic vertebral hemangioma  

PubMed Central

Vertebral hemangiomas are benign vascular tumors of the spine that remain asymptomatic in most cases and incidentally encountered on imaging. Rarely, altered hemodynamic and hormonal changes during pregnancy may expand these benign lesions resulting in severe cord compression. The management of symptomatic vertebral hemangioma during pregnancy is controversial as modalities like radiotherapy and embolization are not suitable and surgery during pregnancy has a risk of preterm labor. Few cases of pregnancy related symptomatic vertebral hemangioma with marked epidural component have been reported in the literature. We report a case of 23-year-old primigravida who developed rapidly progressive paraparesis at 28 weeks of gestation and spine magnetic resonance imaging (MRI) revealed upper thoracic vertebral hemangioma with extensive extra-osseous extension and spinal cord compression. Laminectomy and surgical decompression of the cord was performed at 32 weeks of the pregnancy. There was significant improvement in muscle power after a week of surgery. Six weeks postoperatively she delivered a full term normal baby with subsequent improvement of neurologic deficit. Repeat MRI of dorsal spine performed at 3 months postoperatively showed reduced posterior and anterior epidural components of vertebral hemangioma. PMID:24753678

Gupta, Meena; Nayak, Rajeev; Singh, Hukum; Khwaja, Geeta; Chowdhury, Debashish

2014-01-01

41

Benign Mass in Tonsil- Cavernous Hemangioma  

PubMed Central

Cavernous hemangioma is also called as ‘ANGIOMA CAVERNOSUM’ or ‘CAVERNOMA’ as benign lesion of blood vessels. They are similar to strawberry hemangioma but deeply situated. Although most often associated with skin it is also sometimes found in mucous membrane, brain and the viscera. The diagnosis of hemangiomas is mainly based on clinical evaluation . Isolated hemangiomas in the tonsillar tissue is a rare occurance. In this we report had a case of adult tonsillar hemangioma of left side associated with recurrent tonsillitis . He was effectively managed surgically without any complications. PMID:24298502

Joseph, Sumitha; Prakash, M.; Mohammed, Hafida K; Govar, Aberna

2013-01-01

42

Epithelioid hemangioma of the testis.  

PubMed

Testicular hemangioma is a very rare benign vascular neoplasm, there are only less than 30 cases of testicular hemangiomas reported in the literature. We report a case of epithelioid hemangioma of the testis in a 53-year-old man who presented with painless mass in the right testis. An orchiectomy was performed, The 1 cm tumor was composed of prominent proliferation of small, capillary-sized vessels lined by plump, epithelioid endothelial cells. Immunohistochemically, the epithelioid endothelial cells reacted with antibodies to factor VIII-related antigen, CD31, CD34 and Vimentin, but not CK, EMA, CEA, S-100 and CD68. Although it is a rare tumor, we should be aware of it and avoid confusion with other vascular neoplasm. PMID:24441238

Liu, Xibo; Wang, Ruifen; Guan, Wenbin; Wang, Lifeng

2013-01-01

43

Rapidly Involuting Congenital Hemangioma with Fetal Involution.  

PubMed

Uncommon congenital hemangiomas differ from common infantile hemangiomas in their appearance, postnatal behavior, histopathology, and immunohistologic staining. Two types are well described in the literature: noninvoluting congenital hemangioma (NICH) and rapidly involuting congenital hemangioma (RICH). We report a series of infants with another presentation of congenital hemangioma that arises prenatally and is nearly regressed at birth. This was a retrospective case series. We describe six infants with unusual congenital vascular tumors. Each lesion presented at birth as a violaceous, atrophic plaque with a surrounding pale halo. The lesions involuted in infancy, fading in color and becoming atrophic, with prominent central veins, similar to RICH in the final stage of regression. The distinctive morphology and behavior suggests that these tumors undergo a life cycle of proliferation and involution during fetal life. We describe a new variant of congenital hemangioma that we refer to as rapidly involuting congenital hemangioma with fetal involution. PMID:25492638

Maguiness, Sheilagh; Uihlein, Lily Changchien; Liang, Marilyn G; Kozakewich, Harry; Mulliken, John B

2014-12-10

44

Sclerosing hemangioma of the lung.  

PubMed

A well circumscribed nodular mass discovered on routine chest ray examination, in the left inferior lobe of an otherwise healthy 49-year-old male. Histopathologically the lesion corresponded to a typical so called sclerosing hemangioma. The clinical and histopathological features are described. The sclerosing hemangioma of the lung is a rare benign tumor. Its histogenesis has not been explained yet. Following the electron-microscopic and immunohistochemical researches the opinions have been still unhomogeneous. Therefore, it is concluded that is a tumor of epithelial, endothelial, mesenchymal and even mesothelial origin. This study deals with this tumor, its immunohistochemical analysis points at its epithelial character. PMID:12938610

Halkic, Nermin; Dusmet, Michael; Abdelmoumene, Amina; Pezzetta, Edgardo; Lemoine, Robert; Ris, Hans-Beat

2003-01-01

45

Giant hepatic adenoma with bone marrow metaplasia not associated with oral contraceptive intake  

PubMed Central

Background Hepatocellular adenomas are the most common benign liver tumors. They are usually related to oral contraceptive intake. Case presentation This case describes a 58-year-old woman admitted to our institution for a hepatic mass incidentally discovered during a routine examination. The patient, who was never on oral contraceptives, was asymptomatic upon admission. She underwent a thorough diagnostic evaluation and then a hepatic right trisegmentectomy. The histologic evaluation of the mass showed that it was a hepatocellular adenoma with areas of bone marrow metaplasia. Conclusion Bone marrow metaplasia has rarely been found associated to liver tumors. The presence of marrow-derived hepatic progenitor cells might be the source of both adenoma hepatocytes and bone marrow differentiated cells. To our knowledge, this is only the second case in the English literature in which areas of bone marrow metaplasia were found in a hepatocellular adenoma. PMID:16934137

Ramacciato, Giovanni; Nigri, Giuseppe R; Aurello, Paolo; D'Angelo, Francesco; Pezzoli, Francesca; Rossi, Simone; Pilozzi, Emanuela; Ercolani, Giorgio; Ravaioli, Matteo

2006-01-01

46

Biology of Infantile Hemangioma  

PubMed Central

Infantile hemangioma (IH), the most common tumor of infancy, is characterized by an initial proliferation during infancy followed by spontaneous involution over the next 5–10?years, often leaving a fibro-fatty residuum. IH is traditionally considered a tumor of the microvasculature. However, recent data show the critical role of stem cells in the biology of IH with emerging evidence suggesting an embryonic developmental anomaly due to aberrant proliferation and differentiation of a hemogenic endothelium with a neural crest phenotype that possesses the capacity for endothelial, hematopoietic, mesenchymal, and neuronal differentiation. Current evidence suggests a putative placental chorionic mesenchymal core cell embolic origin of IH during the first trimester. This review outlines the emerging role of stem cells and their interplay with the cytokine niche that promotes a post-natal environment conducive for vasculogenesis involving VEGFR-2 and its ligand VEGF-A and the IGF-2 ligand in promoting cellular proliferation, and the TRAIL-OPG anti-apoptotic pathway in preventing cellular apoptosis in IH. The discovery of the role of the renin–angiotensin system in the biology of IH provides a plausible explanation for the programed biologic behavior and the ?-blocker-induced accelerated involution of this enigmatic condition. This crucially involves the vasoactive peptide, angiotensin II, that promotes cellular proliferation in IH predominantly via its action on the ATIIR2 isoform. The role of the RAS in the biology of IH is further supported by the effect of captopril, an ACE inhibitor, in inducing accelerated involution of IH. The discovery of the critical role of RAS in IH represents a novel and fascinating paradigm shift in the understanding of human development, IH, and other tumors in general. PMID:25593962

Itinteang, Tinte; Withers, Aaron H. J.; Davis, Paul F.; Tan, Swee T.

2014-01-01

47

[Adrenal gland hemangioma: a case report].  

PubMed

Hemangioma is a benign vascular tumor composed of angioblastic cells. The adrenal gland localization is very rare, with only fifty cases reported in literature. We report a case of adrenal gland hemangioma diagnosed in a 55-year-old woman who presented a cervical neoplasm. The non-specific imaging features, the tumor size and the clinical context led to mandatory surgical resection. The pathological examination established the diagnosis of adrenal gland hemangioma. PMID:17194976

Harzallah, L; Zouari, L; Ben Chérifa, L; Harzallah, F; Sriha, B; Bakir, D; Kraiem, Ch

2006-12-01

48

Hepatitis  

MedlinePLUS

... be serious. Some can lead to scarring, called cirrhosis, or to liver cancer. Sometimes hepatitis goes away by itself. If it does not, it can be treated with drugs. Sometimes hepatitis lasts a lifetime. Vaccines can help prevent some viral forms.

49

Hepatitis  

MedlinePLUS

... partner. Increased rates of hepatitis A infection among gay and bisexual men have been reported in many ... by many physicians with a large number of gay and bisexual male patients. As with all STDs, ...

50

Tufted hemangioma: clinical case and literature review  

PubMed Central

Tufted hemangiomas are relatively rare benign vascular proliferations that are congenital or appear during the first years of life. Herein we present an additional case of tufted hemangioma that appeared one year after birth and discuss its histopathological criteria and differential diagnosis with malignant vascular proliferations including sarcoma Kaposi, angiosarcoma and kaposiform hemangioendothelioma. PMID:24855571

Kazlouskaya, Viktoryia; Lytvynenko, Bohdan; Blochin, Elen

2014-01-01

51

Ethylene-vinyl alcohol copolymer endobiliary obliteration of hepatic segments in a patient with isolated bile leaks.  

PubMed

A 54-year-old woman with a symptomatic giant hepatic hemangioma underwent an extended left hepatic trisegmentectomy complicated by 250-350 mL/d postoperative bilious drainage. After 5 months of therapy, drainage was unabated, and the patient was no longer a surgical candidate. Sinography revealed three distinct isolated bile duct leaks involving segments 6, 7, and 8. Endobiliary segmentectomy was achieved by obliterating the isolated systems with ethylene-vinyl alcohol copolymer (Onyx; ev3, Plymouth, Minnesota) during three fluoroscopic procedures. Bilious leaks were successfully eliminated, and compensatory hypertrophy of noninvolved liver occurred. At 2 years from the last embolization procedure, the patient remained asymptomatic with no bilious leak. PMID:25442143

Wible, Brandt C; Gooden, Christie; Saucier, Nathan; Borsa, John J; Cummings, Lee S; Cho, Kenneth H

2014-11-01

52

Extragingival pyogenic granuloma histologically mimicking capillary hemangioma  

PubMed Central

Pyogenic granuloma is a tumor-like proliferation to a non-specific infection. The tumor-like growth is considered to be non-neoplastic in nature and presents in various clinical and histological forms in the oral cavity. Hemangiomas are benign vascular anomalies characterized by benign proliferation of blood vessels. The aim of this article is to drive attention toward the uncommon location of capillary hemangioma on the palate. In spite of their benign nature, intraoral capillary hemangiomas are always clinically important to be diagnosed well in time and suitably managed. The lesion in the present case although clinically diagnosed as pyogenic granuloma gave a histological picture of capillary hemangioma when surgically excised. PMID:25425828

Dahiya, Ritu; Kathuria, Abhinav

2014-01-01

53

Treatment of choroid hemangioma with argon laser  

NASA Astrophysics Data System (ADS)

The treatment effects of 7 cases of choroid hemangioma are reported. Of them, 4 cases were men and 3 cases were women. Ages varied from 34 to 52 years. The mean age was 43 years. All of their eyesight was between 0.01 and 0.4. Six of the seven cases were solitary hemangioma, the other one was Sturge-Weber syndrome. After treatment photography, the color of the hemangioma body gradually got weak and the local presented pigmentation. The results of the fluorescein fundus angiography indicated that the hemangioma body reduced, then got atrophy and fibrosis. In five cases eyesight increased, and it didn't in the other two cases.

Yang, Chuanzhu; Song, Man

1993-03-01

54

Pathogenesis of human hemangiosarcomas and hemangiomas.  

PubMed

Hemangiosarcomas are uncommon aggressive vascular tumors that have recently become the focus of attention because several chemicals and pharmaceuticals increase their incidence in mice. The relevance of these mouse vascular tumors to humans is unclear. In the present study, we semiquantitatively evaluated the expression profiles of hematopoietic stem cell markers (CD117 [c-kit], CD133, CD34, and CD45), endothelial cell markers (vascular endothelial growth factor receptor 2, CD31, and factor VIII-related antigen), and a myeloid lineage cell marker (CD14) in human hemangiosarcoma (n = 12) and hemangioma (n = 10) specimens using immunohistochemistry. CD133 was completely negative in almost all cases of hemangiosarcomas and hemangiomas. Most hemangiosarcomas, but not hemangiomas, stained for CD117 and CD45. Both groups diffusely expressed CD34, vascular endothelial growth factor receptor 2, and factor VIII-related antigen; however, hemangiomas had more intense and diffuse CD34 and factor VIII-related antigen expression compared with hemangiosarcomas, whereas CD31 was positive in all hemangiosarcomas but only half of the hemangiomas. CD14 staining was negative in most hemangiosarcoma and hemangioma cases. Our results indicate that multipotential bone marrow-derived hematopoietic stem cells or early endothelial progenitor cells (EPCs) expressing CD117, CD34, and CD45 are involved in hemangiosarcoma formation, whereas hemangiomas originate from late EPCs or differentiated endothelial cells, which have lost the expression of most hematopoietic stem cell markers. This contrasts with our previous results that demonstrated that both hemangiosarcomas and hemangiomas in mice may be derived from early EPCs that are not completely differentiated. PMID:24054722

Liu, Liping; Kakiuchi-Kiyota, Satoko; Arnold, Lora L; Johansson, Sonny L; Wert, David; Cohen, Samuel M

2013-10-01

55

Adult laryngeal hemangioma: report of four cases.  

PubMed

Laryngeal hemangiomas in adults are uncommon. We report four such cases seen at our clinic during an 18-month period in 1996 and 1997. All masses were detected by endoscopy, and all were biopsied and ablated uneventfully with a CO2 laser. All four patients recovered without incident. We feel that laryngeal hemangiomas that affect only the glottic area can be treated endoscopically with a CO2 laser without consequences. PMID:10969468

Lomeo, P; McDonald, J; Finneman, J

2000-08-01

56

Surgical treatment of infantile subglottic hemangioma.  

PubMed

Three cases of infantile subglottic hemangioma are described. Generally conservative management is favored by most authors. These present lesions were removed surgically by midline cricotracheotomy. Follow-up showed that all children were well and without complaints. The authors believe that besides management with the CO2 laser and short-term steroid therapy, operative treatment of infantile subglottic hemangioma is a valuable alternative which should receive more attention. All children were decannulated a few days after surgery. PMID:2707979

Mulder, J J; van den Broek, P

1989-02-01

57

Epitheloid hemangioma: a report of two cases.  

PubMed

We report two cases of epitheloid hemangioma presented with multiple nodular lesions over head and neck region. One of them gave history of bleeding on minor trauma. Pyogenic granuloma was considered as a differential diagnosis from the morphological appearance and history of bleeding. Nodular leprosy, sarcoidosis, and secondary syphilis were also considered. Histopathological examination of both was typical of epitheloid hemangioma, an entity commonly overlooked clinically due to its rarity. PMID:25284864

Devi, Basanti; Jena, Swapna; Kar, Debjit; Patro, Sibasish; Behera, Binodini

2014-09-01

58

Epitheloid Hemangioma: A Report of Two Cases  

PubMed Central

We report two cases of epitheloid hemangioma presented with multiple nodular lesions over head and neck region. One of them gave history of bleeding on minor trauma. Pyogenic granuloma was considered as a differential diagnosis from the morphological appearance and history of bleeding. Nodular leprosy, sarcoidosis, and secondary syphilis were also considered. Histopathological examination of both was typical of epitheloid hemangioma, an entity commonly overlooked clinically due to its rarity. PMID:25284864

Devi, Basanti; Jena, Swapna; Kar, Debjit; Patro, Sibasish; Behera, Binodini

2014-01-01

59

Presumptive intramuscular hemangioma of the masseter muscle.  

PubMed

Background Hemangioma is a benign vascular proliferation. Intramuscular hemangiomas are rare, accounting for less than 1% of all hemangiomas, and occur normally in the trunk and extremities. Approximately 10-20% of intramuscular hemangiomas are found in the head and neck region, most often in the masseter muscles. The typical clinical characteristic is a painful soft tissue mass without cutaneous changes. Currently, MRI is the standard imaging technique for diagnosing soft-tissue hemangioma. The optimal management is the surgical resection. Case Report We report a case of 34-year-old male patient consulted for a swelling of 1 year evolution, around the parotid region. On physical examination, a soft, well-contoured lesion of about 2 cm on its long axis was found. MRI showed a space-occupying lesion in the left masseter muscle, with intermediate signal intensity on T1-weighted images and hyperignal intensity on T2-weighted images, containing nodular hypointense foci corresponding to calcification. The presumptive diagnosis of an intramasseteric hemangioma with phlebolith was made based on these findings. The patient was informed about her condition, and treatment options were discussed; however, the patient elected to forgo treatment at that time. Conclusions The possibility of an IMH should be included in the differential diagnosis of any intra-masseteric lesion. The appropriate radiologic examinations especially MRI can enhance accurate preoperative diagnosis; the treatment of choice should be individualized in view of the clinical status of the patient. PMID:25590509

Alami, Badreeddine; Lamrani, Youssef; Addou, Omar; Boubbou, Meryem; Kamaoui, Imane; Maaroufi, Mustapha; Sqalli, Nadia; Tizniti, Siham

2015-01-01

60

Hemangiomas  

MedlinePLUS

... intralesional injection with steroids with or without liquid nitrogen cryosurgery can be used. If there is also ... threatening. Spastic dysplegia has been associated in 10-12% of the children taking alfa-interferon and as ...

61

Testicular hemangioma: a series of 8 cases.  

PubMed

Testicular hemangioma is a very rare neoplasm with only 25 cases reported in the English literature. We describe 8 cases of testicular hemangioma encountered at our institution between 1992 and 2012. Of the 7 consult cases, 4 were malignant, 1 a Leydig cell tumor, and 2 were recognized as hemangiomas. The patients' ages ranged from 9 to 54 years (mean 32; median 30). Seven patients presented with self-detected palpable masses, and 2 patients reported pain. Six hemangiomas involved the right testis, and 2 were left sided. Ultrasonography recognized hypervascularity in 3 cases. History of pelvic irradiation, chemotherapy, and remote scrotal trauma was present in 3 patients. Preoperative serum tumor markers were negative (2/2 cases). The average size was 1.7 cm (median 1.8; range, 0.5 to 3.0). Six cases were infiltrative within the testis and entrapped benign seminiferous tubules, and 3 tumors invaded the tunica albuginea. Three hemangiomas were epithelioid, 2 anastomosing, 1 cellular capillary, 1 capillary, and 1 cavernous. Mitoses were sparse in all but 1 case, which reached up to 5 per 10 HPF. In 6 cases, seminiferous tubules adjacent to the hemangioma were atrophic without spermatogenesis. Immunohistochemical analysis was performed in 6 cases, and tumors stained with CD31, CD34, FVIII-related protein, and FLI-1 but not with pancytokeratin AE1/3, epithelial membrane antigen, keratin 8/18, placental alkaline phosphatase, human herpes virus 8, human chorionic gonadotropin, c-kit, melan-A, or p53. In cases with follow-up, there were no recurrences in 7 patients (mean 21 mo; median 12 mo; range, 1 to 72 mo). In summary, testicular hemangioma is a rare neoplasm with different morphologies having in common an infiltrative growth pattern with entrapment of seminiferous tubules, which should not be considered a feature of malignancy. Clinical and radiologic findings may preoperatively suggest a vascular tumor. PMID:23665824

Kryvenko, Oleksandr N; Epstein, Jonathan I

2013-06-01

62

Presumptive Intramuscular Hemangioma of the Masseter Muscle  

PubMed Central

Patient: Male, 34 Final Diagnosis: Intramuscular hemangioma of the masseter muscle Symptoms: Swelling over parotid region Medication: — Clinical Procedure: Clinical-Radiological work-up Specialty: Radiology Objective: Rare disease Background: Hemangioma is a benign vascular proliferation. Intramuscular hemangiomas are rare, accounting for less than 1% of all hemangiomas, and occur normally in the trunk and extremities. Approximately 10–20% of intramuscular hemangiomas are found in the head and neck region, most often in the masseter muscles. The typical clinical characteristic is a painful soft tissue mass without cutaneous changes. Currently, MRI is the standard imaging technique for diagnosing soft-tissue hemangioma. The optimal management is the surgical resection. Case Report: We report a case of 34-year-old male patient consulted for a swelling of 1 year evolution, around the parotid region. On physical examination, a soft, well-contoured lesion of about 2 cm on its long axis was found. MRI showed a space-occupying lesion in the left masseter muscle, with intermediate signal intensity on T1-weighted images and hyperignal intensity on T2-weighted images, containing nodular hypointense foci corresponding to calcification. The presumptive diagnosis of an intramasseteric hemangioma with phlebolith was made based on these findings. The patient was informed about her condition, and treatment options were discussed; however, the patient elected to forgo treatment at that time. Conclusions: The possibility of an IMH should be included in the differential diagnosis of any intra-masseteric lesion. The appropriate radiologic examinations especially MRI can enhance accurate preoperative diagnosis; the treatment of choice should be individualized in view of the clinical status of the patient. PMID:25590509

Alami, Badreeddine; Lamrani, Youssef; Addou, Omar; Boubbou, Meryem; Kamaoui, Imane; Maaroufi, Mustapha; Sqalli, Nadia; Tizniti, Siham

2015-01-01

63

Ulcerated hemangiomas: Clinical characteristics and response to therapy  

Microsoft Academic Search

Background: Hemangiomas represent the most common benign tumor of infancy, with ulceration its most frequent complication. Objective: Our purpose was to review our experience with this challenging problem by evaluating the clinical features, management, and therapeutic responses of ulcerated hemangiomas. Methods: A retrospective analysis of ulcerated hemangiomas at the University of California, San Francisco outpatient pediatric dermatology clinics and Oakland

Ho Jin Kim; Mary Colombo; Ilona J. Frieden

2001-01-01

64

Diffuse Hepatic Hemangiomatosis in the Adult without Extra-hepatic Involvement: An Extremely Rare Occurrence.  

PubMed

We present a case of a pathologically proven multinodular diffuse hepatic hemangiomatosis (DHH) with no extra-hepatic involvement in a 68-year-old male. Cavernous hemangioma is the most common hepatic tumor. However, DHH, which is characterized by extensive replacement of liver parenchyma with hemangiomatous lesions, has been rarely reported in adults. The etiology and clinical course are not completely understood because of its rareness, although the diagnosis might be suggested by the magnetic resonance imaging findings. PMID:25250192

Batista, Alexandre; Matos, António Pedro; Neta, Jorge Oliveira E; Ramalho, Miguel

2014-01-01

65

Diffuse Hepatic Hemangiomatosis in the Adult without Extra-hepatic Involvement: An Extremely Rare Occurrence  

PubMed Central

We present a case of a pathologically proven multinodular diffuse hepatic hemangiomatosis (DHH) with no extra-hepatic involvement in a 68-year-old male. Cavernous hemangioma is the most common hepatic tumor. However, DHH, which is characterized by extensive replacement of liver parenchyma with hemangiomatous lesions, has been rarely reported in adults. The etiology and clinical course are not completely understood because of its rareness, although the diagnosis might be suggested by the magnetic resonance imaging findings. PMID:25250192

Batista, Alexandre; Matos, António Pedro; Neta, Jorge Oliveira e; Ramalho, Miguel

2014-01-01

66

[Littoral hemangioma of the spleen].  

PubMed

The authors report a rare case of littoral hemangioma of the spleen (LHS) accompanied by a revision of the literature on the argument. A male 65-year-old patient was referred to their attention with suspected ultrasonographic diagnosis of lymphoma with a splenic localisation. The complete CT diagnosis led to suspected splenic angioma. During surgery, anatomopathological analysis of the biopsy revealed LHS. The pathological anatomy showed lesions ranging in size from small foci to large nodules which almost completely replaced the splenic parenchyma. These areas were made up of vascular canals or axes that imitate splenic sinuses and have irregular lumen, often appearing as papillary projections and cyst-like spaces; they are bordered by high (cylindrical) endothelial cells that project into the vascular lumen and reveal hemophagocytosis; there is very little mitotic activity. The patient was discharged 7 days after surgery. The authors underline the extreme rarity of this neoplasm and the virtual absence of symptoms, although some cases report signs of hypersplenism, including platelet deficiency and anemia. The diagnostic iter must take care to exclude other pathologies affecting the spleen, including lymphoma, metastases and primary malignant splenic tumours. Lastly, a differential diagnosis must be made with the malignant variant, littoral hemangiosarcoma of the spleen. PMID:11283486

Voghera, P; Fontana, D; Coverlizza, S; Fusca, M; Della Beffa, V; Pisacane, A M

2001-02-01

67

Beta-blockers for hemangiomas.  

PubMed

Infantile hemangiomas (IHs) are the most common tumors of infancy. Their typical natural history is characterized by an early rapid growth in the first months of life and by a slow spontaneous involution in the first years of life. Even though spontaneous regression of IHs could suggest therapeutic abstention, systemic treatment is the therapy of choice in many patients in which these situations occur: 1) rapid growth of IHs; 2) location of IHs in aesthetically critic areas; 3) recurrent hemorrhages, ulcerations or infections of IHs; 3 IHs interfering with important physiological functions (breathing, feeding, vision, hearing, etc.) 4) large or multicentric IHs that can cause heart failure. Since 2008, systemic administration of propranolol, an old non-selective ?-blocker, was found, serendipitously, to improve the treatment of IHs replacing older and more dangerous therapies like oral steroids, vincristine, interferon-alpha or vascular lasers. At present, oral propranolol has dramatically changed the approach of IHs because its efficacy is almost 100% and its action is rapid, without important side effects. The formal approval by FDA and EMA has been obtained in Spring 2014. PMID:25366892

Gelmetti, C; Cavalli, R

2014-11-01

68

Photodynamic Therapy for Juxtapapillary Retinal Capillary Hemangioma  

PubMed Central

Various treatment modalities have been described for retinal capillary hemangioma. Our purpose is to present a case of juxtapapillary retinal capillary hemangioma treated with photodynamic therapy. A 69-year-old woman with no previous ocular history presented with blurred vision and photopsias in the right eye three months ago. At presentation, her best corrected visual acuity was 6/9 in the right eye and 6/6 in the left eye. The anterior segment was totally normal and IOP was normal in both eyes as well. Dilated fundoscopy revealed a yellowish, well-circumscribed, elevated area with blood vessels, on the inferior margin of the right optic disc, as optic disc edema. Fluorescein angiography and angiogram with indocyanine green confirmed the diagnosis of juxtapapillary retinal capillary hemangioma. The patient was treated with photodynamic therapy with verteporfin and three months later her visual acuity was 6/7.5 in the right eye, while the lesion was slightly smaller. These findings remained stable at the one-year follow-up. In conclusion, photodynamic therapy offers promising anatomical and functional results for juxtapapillary retinal capillary hemangioma, providing visual acuity improvement or even stabilization and restriction of enlargement of the lesion. PMID:24716060

Mitropoulos, Panagiotis G.; Chatziralli, Irini P.; Peponis, Vasileios G.; Tsiotra, Vasileia A.; Parikakis, Efstratios A.

2014-01-01

69

Masson's hemangioma: A rare intraoral presentation  

PubMed Central

An otherwise healthy 19-year-old female patient had painless swelling in her left buccal mucosa. No precipitating factors were identified. Pathological analysis demonstrated the mass to be a Masson's hemangioma, a papillary proliferation of thin-walled capillaries intimately associated with thrombus. A very rare tumor occurring in oral cavity with only 80 cases being published in literature until date. PMID:24124316

Narwal, Anjali; Sen, Rajeev; Singh, Virender; Gupta, Ambika

2013-01-01

70

A Rapidly Enlarging Cutaneous Hemangioma in Pregnancy  

PubMed Central

This is a case of a rapidly enlarging cutaneous pedunculated tumor on a patient’s thumb during her pregnancy. This was excised and identified as a hemangioma. A literature search identified a possible hormonal factor in causing an accelerated growth of this tumor. PMID:25332760

Ma’ayeh, Marwan; Purandare, Nikhil; Harrison, Michelle; Geary, Michael P.

2014-01-01

71

A rapidly enlarging cutaneous hemangioma in pregnancy.  

PubMed

This is a case of a rapidly enlarging cutaneous pedunculated tumor on a patient's thumb during her pregnancy. This was excised and identified as a hemangioma. A literature search identified a possible hormonal factor in causing an accelerated growth of this tumor. PMID:25332760

Ma'ayeh, Marwan; Purandare, Nikhil; Harrison, Michelle; Geary, Michael P

2014-06-18

72

Hypopharyngeal hemangioma in an adult: a case report.  

PubMed

Hemangiomas of the postcricoid region have been reported almost exclusively in infants and young children. Our adult patient with symptoms of dysphagia and weight loss underwent transoral CO2 laser microsurgery of a postcricoid mass, and final pathologic examination confirmed the presence of a hemangioma. She is doing well after surgery, with an excellent voice, resolution of dysphagia, and no evidence of recurrence. There have been few cases of hypopharyngeal hemangioma in the adult population; to our knowledge, there have been no reports in the English-language literature of adult patients diagnosed specifically with a postcricoid hemangioma. Otolaryngologists should be familiar with the presentation and treatment of this unusual entity. PMID:25397385

Reder, Lindsay; Verma, Sunil; Kokot, Niels

2014-01-01

73

Capillary Hemangioma in Maxillary Anterior Region: A Case Report  

PubMed Central

ABSTRACT Hemangiomas are relatively common benign proliferative lesion of vascular tissue origin. They are often present at birth and may become more apparent throughout life. They are seen on facial skin, tongue, lips, buccal mucosa and palate as well as muscles. Hemangiomas occur more common in females than males. This case report presents a case of capillary hemangioma in maxillary anterior region in a 10-year-old boy. How to cite this article: Satish V, Bhat M, Maganur PC, Shah P, Biradar V. Capillary Hemangioma in Maxillary Anterior Region: A Case Report. Int J Clin Pediatr Dent 2014;7(2):144-147. PMID:25356016

Bhat, Manohar; Maganur, Prabhadevi C; Shah, Parth; Biradar, Vijay

2014-01-01

74

Update on the classification of hemangioma  

PubMed Central

Despite the fact that a biological classification of congenital vascular tumors and malformations was first published in 1982 by Mulliken and Glowacki, significant confusion still prevails due to the indiscriminate and interchangeable use of the terms hemangioma and vascular malformation. Hemangiomas are true neoplasms of endothelial cells and should be differentiated from vascular malformations which are localized defects of vascular morphogenesis. On an analysis of various scientific articles and latest edition of medical text books an inappropriate use of various terms for vascular lesions was found, contributing further towards the confusion. The widely accepted International Society for the Study of Vascular Anomalies (ISSVA) classification differentiates lesions with proliferative endothelium from lesions with structural anomalies and has been very helpful in standardizing the terminologies. In addition to overcoming obstacles in communication when describing a vascular lesion, it is important that we adhere to the correct terminology, as the therapeutic guidelines, management and follow-up of these lesions differ. PMID:25364160

George, Antony; Mani, Varghese; Noufal, Ahammed

2014-01-01

75

Update on the classification of hemangioma.  

PubMed

Despite the fact that a biological classification of congenital vascular tumors and malformations was first published in 1982 by Mulliken and Glowacki, significant confusion still prevails due to the indiscriminate and interchangeable use of the terms hemangioma and vascular malformation. Hemangiomas are true neoplasms of endothelial cells and should be differentiated from vascular malformations which are localized defects of vascular morphogenesis. On an analysis of various scientific articles and latest edition of medical text books an inappropriate use of various terms for vascular lesions was found, contributing further towards the confusion. The widely accepted International Society for the Study of Vascular Anomalies (ISSVA) classification differentiates lesions with proliferative endothelium from lesions with structural anomalies and has been very helpful in standardizing the terminologies. In addition to overcoming obstacles in communication when describing a vascular lesion, it is important that we adhere to the correct terminology, as the therapeutic guidelines, management and follow-up of these lesions differ. PMID:25364160

George, Antony; Mani, Varghese; Noufal, Ahammed

2014-09-01

76

Spontaneous rupture of splenic hemangioma in puerperium.  

PubMed

Atraumatic splenic rupture is a rare clinical entity and in the absence of trauma, the diagnosis and treatment are often delayed. In this article the authors discuss a case of a 45-year-old woman, gravida 5, para 4, with spontaneous splenic rupture on her second postpartum day. The rupture was related to a splenic hemangioma that is a vascular malformation and the most common neoplasm of the spleen. Despite the fact that hemangiomas are the most common primary neoplasms of the spleen, only few cases of splenic rupture have been described in pregnancy or puerperium. However, spontaneous splenic rupture is a rare event and the rupture should be suspected in woman with unexplained abdominal pain or with clear signs of haemorrhage. PMID:23157060

Carta, G; D'Alfonso, A; Nallbani, A; Palermo, P; Franchi, V; Patacchiola, F

2012-01-01

77

Progesterone receptor expression in orbital cavernous hemangiomas  

Microsoft Academic Search

Orbital cavernous hemangiomas (OCH) have thick and highly cellular vascular walls. Ultrastructural studies have demonstrated\\u000a the smooth muscle nature of these cells. Vascular neoplasms can modify their morphological and clinical features under hormonal\\u000a stimulation. The purpose of the present study was to investigate the presence of smooth muscle markers and sex steroid receptors\\u000a in 12 cases of OCH. Orbital cases

Luca Di Tommaso; Francesca Scarpellini; Fabrizio Salvi; Teresa Ragazzini; Maria P. Foschini

2000-01-01

78

Intraventricular Cavernous Hemangiomas Located at the Foramen of Monro  

PubMed Central

Intraventricular cavernous hemangiomas are uncommon. Among them, those occurred at the foramen of Monro in the third ventricle may be of particular interest because of its rarity, development of hydrocephalus, being differentiated from other brain lesions. We present a rare case of intraventricular cavernous hemangioma at foramen of Monro which was resected through microsurgery and also review the relevant literatures. PMID:23091674

Choi, Chan-Young; Lee, Chae-Heuck

2012-01-01

79

Cavernous hemangioma located at the foramen of Monro: Radiopathological correlation  

PubMed Central

Intraventricular cavernous hemangiomas are rare. Amongst them, cavernomas located at the foramen of Monro are of greater interest because of their rare location, varied symptoms, and often association with hydrocephalus. We present a rare case of cavernous hemangioma located at foramen of Monro, with its radiopathological confirmation. PMID:24347847

Bhatia, Sonia; Kapoor, Abhay K; Gupta, Rajiv; Sahni, Tushar

2013-01-01

80

Multipotential stem cells recapitulate human infantile hemangioma in immunodeficient mice  

PubMed Central

Infantile hemangioma is a benign endothelial tumor composed of disorganized blood vessels. It exhibits a unique life cycle of rapid postnatal growth followed by slow regression to a fibrofatty residuum. Here, we have reported the isolation of multipotential stem cells from hemangioma tissue that give rise to hemangioma-like lesions in immunodeficient mice. Cells were isolated based on expression of the stem cell marker CD133 and expanded from single cells as clonal populations. The CD133-selected cells generated human blood vessels 7 days after implantation in immunodeficient mice. Cell retrieval experiments showed the cells could again form vessels when transplanted into secondary recipients. The human vessels expressed GLUT-1 and merosin, immunodiagnostic markers for infantile hemangioma. Two months after implantation, the number of blood vessels diminished and human adipocytes became evident. Lentiviral expression of GFP was used to confirm that the hemangioma-derived cells formed the blood vessels and adipocytes in the immunodeficient mice. Thus, when transplanted into immunodeficient mice, hemangioma-derived cells recapitulated the unique evolution of infantile hemangioma — the formation of blood vessels followed by involution to fatty tissue. In summary, this study identifies a stem cell as the cellular origin of infantile hemangioma and describes for what we believe is the first time an animal model for this common tumor of infancy. PMID:18535669

Khan, Zia A.; Boscolo, Elisa; Picard, Arnaud; Psutka, Sarah; Melero-Martin, Juan M.; Bartch, Tatianna C.; Mulliken, John B.; Bischoff, Joyce

2008-01-01

81

Capillary hemangioma managed by the CO2 laser.  

PubMed

The case is presented of a young woman with a large cervical capillary hemangioma that was surgically removed with the carbon dioxide (CO2) laser. A survey of the literature discloses 27 similar cases of hemangioma. A discussion of this form of surgical management as well as the physical characteristics of the CO2 laser is presented. PMID:7352054

Bellina, J H; Gyer, D R; Voros, J I; Raviotta, J J

1980-01-01

82

Low-Dose Proton Beam Therapy for Circumscribed Choroidal Hemangiomas  

Microsoft Academic Search

Objective: To evaluate the efficacy and safety of pro- ton beam therapy for complicated circumscribed cho- roidal hemangiomas. Methods: The study was a retrospective nonrandom- ized investigation. Seventeen consecutive patients, re- ferred to the Institut Gustave-Roussy, Villejuif, France, for circumscribed choroidal hemangioma associated with serous retinal detachment were studied. Each eye re- ceived a total dose of 20 cobalt gray

Eric Frau; Frank Rumen; George Noel; Sabine Delacroix; Jean-Louis Habrand

2004-01-01

83

Low-Dose Proton Beam Therapy for Circumscribed Choroidal Hemangiomas  

Microsoft Academic Search

Objective: To evaluate the efficacy and safety of pro- ton beam therapy for complicated circumscribed cho- roidal hemangiomas. Methods: The study was a retrospective nonrandom- ized investigation. Seventeen consecutive patients, re- ferred to the Institut Gustave-Roussy, Villejuif, France, for circumscribed choroidal hemangioma associated with serous retinal detachment were studied. Each eye re- ceived a total dose of 20 cobalt gray

Eric Frau; Frank Rumen; George Noel; Sabine Delacroix; Jean-Louis Habrand

84

Atlas of hepatic tumors and focal lesions: Arteriographic and tomographic diagnosis  

SciTech Connect

This book describes the diagnosis of liver tumors. Topics considered include general considerations, hepatocellular carcinoma, hepatoblastoma, cholangiocarcinoma, mesenchyomoma, sarcoma, hemangioma, hepatic cell adenoma, focal nodular hyperlasia (FNH), hamartoma, echinococcus cyst, abscess, AV fistula, hepatic artery aneurysm, metastatic carcinoma-colon, metastatic cholangiocarcinoma, metastatic melanoma, metastatic merkel cell and extrahepatic tumor.

Gutierrez, O.; Schwartz, S.I.

1984-01-01

85

Sclerosing cholangitis secondary to bleomycin-iodinated embolization for liver hemangioma.  

PubMed

Sclerosing cholangitis (SC) is a rarely reported morbidity secondary to transcatheter arterial chemoembolization (TACE) with bleomycin-iodinated oil (BIO) for liver cavernous hemangioma (LCH). This report retrospectively evaluated the diagnostic and therapeutic course of a patient with LDH who presented obstructive jaundice 6 years after TACE with BIO. Preoperative imaging identified a suspected malignant biliary stricture located at the convergence of the left and right hepatic ducts. Operative exploration demonstrated a full-thickness sclerosis of the hilar bile duct with right hepatic duct stricture and right lobe atrophy. Radical hepatic hilar resection with right-side hemihepatectomy and Roux-en-Y hepaticojejunostomy was performed because hilar cancer could not be excluded on frozen biopsy. Pathological results showed chronic pyogenic inflammation of the common and right hepatic ducts with SC in the portal area. Secondary SC is a long-term complication that may occur in LCH patients after TACE with BIO and must be differentiated from hilar malignancy. Hepatic duct plasty is a definitive but technically challenging treatment modality for secondary SC. PMID:25516686

Jin, Shuo; Shi, Xiao-Ju; Sun, Xiao-Dong; Wang, Si-Yuan; Wang, Guang-Yi

2014-12-14

86

Masson's Hemangioma of Proximal Radial Artery.  

PubMed

Tumour like vascular lesions are rare. Here we report a rare case of tumor like vascular lesion from the radial artery. A pulsatile swelling in the forearm is usually diagnosed as a case of Aneurysm, AV fistula or highly vascular tumor. A middle aged man came to us with a painless pulsatile swelling on the lateral aspect of proximal right forearm. The ultrasound scan reported it as case of vascular tumour. Angiogram showed abnormal vascular channels, connected to the aneurysmal dialation of the proximal radial artery. Histopthological examination confirmed it as Masson's hemangioma after excision. This is a benign condition and complete excision is curative. PMID:24799774

Pinjala, Ramakrishna

2014-02-01

87

Pathology Case Study: Hemangioma and Severe Thrombocytopenia  

NSDL National Science Digital Library

This is a transfusion pathology case study presented by the University of Pittsburgh Department of Pathology in which a 3-week-old female has hemangioma and severe thrombocytopenia. Visitors are given laboratory values and images, and are granted the opportunity to diagnose the patient. This is an excellent resource for students in the health sciences to familiarize themselves with using laboratory results to diagnose. It is also a helpful site for educators to use to introduce or test student learning in transfusion pathology medicine.

Bontempo, Franklin; Dorvault, Christine

2007-10-09

88

Cavernous hemangioma of the parotid gland in adults  

PubMed Central

Hemangiomas account for 0.4-0.6% of all tumors of the parotid gland and most of them occur in children, nevertheless in adults hemangiomas are very rare. We report the case of a 62 year old woman with a mass in the parotid right tail associated with fluctuating swelling episodes unrelated to meals and with a slowly progressive growth. The provisional diagnosis was a pleomorphic adenoma, so a right superficial parotidectomy was performed. During surgery, the macroscopic appearance makes suspect a vascular lesion. The histopathological result was a cavernous hemangioma. The classic clinical presentation of a parotid hemangioma is an intraglandular mass associated or not with skin lesions characterized by reddish macules and/or papules, and a vibration or pulsation when palpating the parotid region. In imaging tests, phleboliths could be observed which are very suggestive of a hemangioma or a vascular malformation. In the absence of these signs, the diagnosis could be difficult, particularly in an adult due to its low prevalence, with about 50 cases reported worldwide. However a hemangioma should be considered in the differential diagnosis of parotid tumors in adults. Key words:Cavernous hemangioma, parotid gland, superficial parotidectomy, pleomorphic adenoma.

Peral-Cagigal, Beatriz; Madrigal-Rubiales, Beatriz; Verrier-Hernández, Alberto

2014-01-01

89

Treatment of alarming head and neck infantile hemangiomas with interferon-?2a: a clinical study in eleven consecutive patients  

PubMed Central

Objective To evaluate the efficacy and adverse effects of interferon-?2a in the treatment of alarming infantile hemangiomas in the head and neck region. Patients and methods From January 2009–December 2010, a subcutaneous injection of interferon-?2a was applied to eleven infants with giant multifocal or segmental hemangiomas at a dose of 3 million units/m2 per day. All patients did not respond to propranolol or corticosteroids. The age at initiation of interferon-?2a therapy ranged from 3 days to 8 months (median: 4 months). The duration of therapy ranged from 2–4.5 months (median: 3 months). Eight patients received medication for 3 months, one patient for 4.5 months, and two patients for 2 months. Results Nine patients had a reduction in tumor mass of 95%; two patients’ tumors decreased in size by 75%. The overall response rate was 100%. The main adverse effects included fever, diarrhea, and anorexia, which resolved after stopping the medication. No serious adverse effect was observed. Conclusion Short-term treatment with interferon-?2a can be used as a safe and effective treatment for alarming infantile hemangiomas that are resistant to propranolol or corticosteroids, and that endanger the proper functioning of the affected organ or the patient’s life.

Zhang, Ling; Zheng, Jia Wei; Yuan, Wei En

2015-01-01

90

Subglottic hemangiomas in infants: treatment with CO2 laser.  

PubMed

Subglottic hemangiomas in infants are rare but potentially lethal. Although the majority tend to regress after 12 to 18 months, lethal compromise of the airway is always possible until then. A plethora of treatments have been advocated for subglottic hemangiomas, each with significant morbidity. Eleven consecutive patients have undergone laser resection of subglottic hemangiomas at the University of California, San Francisco. Three infants have been managed without a tracheotomy. If a tracheotomy is required, earlier removal can be achieved with laser resection. No subglottic stenosis or hemorrhage has occurred following laser resection. CO2 laser resection is now the safest and most effective treatment available. PMID:6717221

Mizono, G; Dedo, H H

1984-05-01

91

Open surgical excision of subglottic hemangioma in children.  

PubMed

Subglottic hemangioma is an unusual entity which may involute spontaneously without aggressive surgical intervention; although tracheotomy is sometimes necessary. The actual time course for involution is not clear by reviewing the literature [1,14]. Numerous treatment modalities are described for the treatment of this condition, including tracheotomy, CO2 laser ablation and intralesional steroid injection with or without endotracheal intubation. Surgical resection of subglottic hemangioma is an option which is described in the literature and may be utilized in certain selected cases. We present seven cases of subglottic hemangioma treated at three institutions which were resected via a crico-tracheotomy approach. Postoperative follow-up for these patients range from 6 months to 4.5 years. Although conservative measures are still advocated as the treatment of choice for subglottic hemangioma, open surgical resection may be indicated in selected cases resulting in a satisfactory outcome. PMID:8770689

Wiatrak, B J; Reilly, J S; Seid, A B; Pransky, S M; Castillo, J V

1996-01-01

92

Cavernous hemangioma of the testis mimicking a testicular teratoma.  

PubMed

In this study we report a case of cavernous hemangioma of the testis, which mimicked a testicular teratoma. A 42-year-old male presented with a left testicular swelling that had arisen suddenly and been present for three months. Scrotal ultrasound revealed a hypoechoic mass with several calcifications in the left testicle. The mass demonstrated blood flow in the color Doppler mode. A radical orchiectomy was performed. Pathological evaluation revealed a testicular cavernous hemangioma with thrombus organization and calcification. PMID:23935725

Liu, Ben; Chen, Jun; Luo, Jindan; Zhou, Feng; Wang, Chaojun; Xie, Liping

2013-07-01

93

Cavernous hemangioma of the testis mimicking a testicular teratoma  

PubMed Central

In this study we report a case of cavernous hemangioma of the testis, which mimicked a testicular teratoma. A 42-year-old male presented with a left testicular swelling that had arisen suddenly and been present for three months. Scrotal ultrasound revealed a hypoechoic mass with several calcifications in the left testicle. The mass demonstrated blood flow in the color Doppler mode. A radical orchiectomy was performed. Pathological evaluation revealed a testicular cavernous hemangioma with thrombus organization and calcification. PMID:23935725

LIU, BEN; CHEN, JUN; LUO, JINDAN; ZHOU, FENG; WANG, CHAOJUN; XIE, LIPING

2013-01-01

94

[Rapidly involuting congenital hemangiomas: twenty five case series].  

PubMed

Rapidly involuting congenital hemangiomas are very rare vascular tumours, that are characterized for being completely developed at birth and for involuting in a short period of time after birth. We describe a case series of 25 patients with rapidly involuting congenital hemangiomas. Twelve patients were male and 13 female; they were all born at term. Lesions were small in 17 cases and big in 8. No patient needed active intervention and all lesions showed a rapid initial involution. PMID:24584803

Larralde, Margarita; Solé, Juan Javier; Luna, Paula Carolina; Mosquera, Tomás; Abad, María Eugenia

2014-04-01

95

Cavernous Hemangioma of Tongue: Management of Two Cases  

PubMed Central

Hemangiomas are benign tumours of infancy and childhood, most commonly located in the head and neck region and occur more frequently in the lips, tongue and palate. The treatment depends upon lesion location, size and evolution stage and the patient’s age. This paper describes the management of cavernous hemangioma in a 2 -year -old child and 14 -year -old child using different approaches. PMID:25478463

Puppala, Niharika; Deshmukh, Sudhanwa N; B, Jagadesh; S, Anuradha

2014-01-01

96

Control for laser hemangioma treatment system  

SciTech Connect

A laser is disclosed for directing a nominally 5 micron wavelength beam at a hemangioma or other variegated lesion. A fiber optic bundle for intercepting radiation reflected from the lesion at an intensity corresponding with the color intensity of the region at which the beam is directed. The output beam from the fiber optic bundle modulates a photodetector stage whose amplified output drives a galvanometer. The galvanometer shaft is coupled to the shaft of a potentiometer which is adjustable to regulate the laser power supply and, hence, the laser output energy level so laser beam energy is reduced when high absorption regions in the lesion are being scanned by the beam and increased as low absorption regions are being scanned.

Muckerheide, M.C.

1982-02-23

97

Cavernous Hemangioma of the Tympanic Membrane  

PubMed Central

Cavernous hemangioma seems to most frequently arise in the posterior portion of the external auditory canal. However, they rarely occur in the tympanic membrane. A 49-year-old male patient was referred for evaluation of right-sided pulsatile tinnitus that he'd experienced for the previous 2 years. Temporal bone computerized tomography showed an isolated soft tissue mass just lateral to the tympanic membrane. There was no evidence of bony erosion or middle ear invasion. The patient underwent excision of the mass using a postauricular approach. The mass was removed en bloc and the defect of the tympanic membrane was repaired by tympanoplasty type I. There was no recurrence after 1 year of follow-up. PMID:21716950

Choi, Hyun Suk; Hong, Yong Sung; Cho, Yong Bum

2011-01-01

98

Proteomic analysis of pulmonary sclerosing hemangioma.  

PubMed

Sclerosing hemangioma (SH) is a rare benign pulmonary tumor derived from the primitive respiratory epithelium. However, the pathogenesis of SH has not yet been clear. Surfactant protein, thyroid transcription factor-1, epithelial membrane antigen, cytokeratin, and vimentin have been identified in SH by immunohistochemistry and electron microscopy. To identify proteins specifically regulated in SH, 2-D PAGE was performed using SH and paired normal tissues. Ten selected differentially expressed protein spots were identified by PMF, MALDI-TOF-MS, and database searching. Apolipoprotein A-1, antizyme inhibitor, heat shock 27-kDa protein 1, and antioxidant proteins, such as peroxiredoxin II (Prx II) and GST, were identified among the down-regulated proteins in SH. Western blot and immunohistochemistry confirmed reduced expressions of Prx II and GST in SH versus normal lung tissue. This study is the first report on the reduced expressions of Prx II and GST in SH. PMID:16892484

Jin, Lian-Jin; Shin, Bong Kyung; Jung, Woon Yong; Lee, Hyun-Juu; Cho, Su Jin; Han, Joung-Ho; Ha, Seong-Yeon; Kim, Ae-Ree; Sik Kim, Young; Sun Kim, In; Uhm, Chang-Sub; Kim, Han Kyeom

2006-09-01

99

Bilateral multifocal hemangiomas of the orbit in the blue rubber bleb nevus syndrome  

Microsoft Academic Search

PurposeTo report the clinical findings and surgical treatment of multifocal, bilateral orbital hemangiomas in a patient with the blue rubber bleb nevus syndrome, a rare vascular disorder characterized by distinctive cutaneous and visceral hemangiomas.

Eli L Chang; Peter A. D Rubin

2002-01-01

100

Proton Beam Irradiation Using a Light-Field Technique for the Treatment of Choroidal Hemangiomas  

Microsoft Academic Search

Background\\/Aims: To describe the clinical outcomes of patients with circumscribed and diffuse choroidal hemangiomas treated by proton beam irradiation using a nonsurgical light-field technique. Methods: A retrospective chart review was performed on a series of 19 patients (19 eyes) with choroidal hemangiomas treated with proton beam therapy between July 1988 and August 2005. Choroidal hemangiomas were treated with proton beam

R. V. Paul Chan; Yoshihiro Yonekawa; Dimitra Skondra; John E. Munzenrider; J. Michael Collier; Evangelos S. Gragoudas; Ivana K. Kim

2010-01-01

101

Intraosseous Cavernous Hemangioma: A Rare Presentation in Maxilla  

PubMed Central

Objective: Hemangiomas are benign vascular lesions mostly arising from soft tissues. However, intraosseous hemangioma is a rare entity, comprising only 1% of benign bone tumors. We describe here the presentation, diagnosis, and treatment of a 42-year-old woman with a painless hard swelling—diagnosed to be intraosseous hemangioma via orbital magnetic resonance imaging—localized on the left infraorbital margin. Methods: After en bloc excision of the mass with safety margins through a subciliary incision, the defect was reconstructed via Medpor, which was fixed to the drilled bones with polypropylene sutures. Results: Histopathological diagnosis of the specimen revealed intraosseous cavernous hemangioma. There seems to be no recurrence or any cosmetic deformity 3 months postoperatively. Conclusion: Total surgical excision is the preferred method of treatment for intraosseous hemangiomas with reconstruction. In this patient, we used Medpor for reconstruction of orbital floor, the infraorbital orbital rim and anterior wall of maxillary sinus. We think that Medpor is a good option since a natural smooth malar contour and adequate orbital rim can be achieved and there is no any other scar. PMID:25328568

I??lgan, Servet Elçin; Çerkez, Cem; Otrakç?, Volkan; Serel, Sava?

2014-01-01

102

Gamma Knife Radiosurgery for Choroidal Hemangioma  

SciTech Connect

Purpose: Patients with choroidal hemangioma (CH), a benign ocular hamartoma, frequently presents with visual disturbance as a result of exudative retinal detachment (RD), which originates in subretinal fluid accumulation. We report our experience using the Leksell Gamma Knife in the management of symptomatic CH. Methods and Materials: Seven patients with symptomatic CH (circumscribed form in 3 patients and diffuse form in 4) were treated with the Leksell Gamma Knife at our institution during a 7-year period. All patients presented with exudative RD involving the macula that resulted in severe visual deterioration. The prescription dose to the target margin was 10 Gy in all cases. The mean tumor volume receiving the prescription dose was 536 mm{sup 3} (range, 151-1,057). The clinical data were analyzed in a retrospective fashion after a mean follow-up of 34.4 months (range, 9-76). Results: The resolution of exudative RD was achieved within 6 months, and the visual acuity of the affected eye had improved at the latest follow-up examination (p = .018) in all patients. No recurrence of exudative RD occurred. Thinning of the CHs was observed in most patients; however, symptomatic radiation toxicity had not developed in any of the patients. Conclusion: Symptomatic CHs can be safely and effectively managed with Gamma Knife radiosurgery using a marginal dose of 10 Gy.

Kim, Yun Taek; Kang, Se Woong [Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of); Lee, Jung-Il, E-mail: jilee@skku.edu [Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of)

2011-12-01

103

Role of connexins in infantile hemangiomas  

PubMed Central

The circulatory system is one of the first systems that develops during embryogenesis. Angiogenesis describes the formation of blood vessels as a part of the circulatory system and is essential for organ growth in embryogenesis as well as repair in adulthood. A dysregulation of vessel growth contributes to the pathogenesis of many disorders. Thus, an imbalance between pro- and antiangiogenic factors could be observed in infantile hemangioma (IH). IH is the most common benign tumor during infancy, which appears during the first month of life. These vascular tumors are characterized by rapid proliferation and subsequently slower involution. Most IHs regress spontaneously, but in some cases they cause disfigurement and systemic complications, which requires immediate treatment. Recently, a therapeutic effect of propranolol on IH has been demonstrated. Hence, this non-selective ?-blocker became the first-line therapy for IH. Over the last years, our understanding of the underlying mechanisms of IH has been improved and possible mechanisms of action of propranolol in IH have postulated. Previous studies revealed that gap junction proteins, the connexins (Cx), might also play a role in the pathogenesis of IH. Therefore, affecting gap junctional intercellular communication is suggested as a novel therapeutic target of propranolol in IH. In this review we summarize the current knowledge of the molecular processes, leading to IH and provide new insights of how Cxs might be involved in the development of these vascular tumors. PMID:23596415

Blanke, Katja; Dähnert, Ingo; Salameh, Aida

2013-01-01

104

Trauma-induced simulator of targetoid hemosiderotic hemangioma.  

PubMed

Reported here is a 15-year-old with lesions demonstrating histologic features of targetoid hemosiderotic hemangioma (THH) developing after trauma to inflammatory lesions. These lesions pose as simulators of THH. Targetoid hemosiderotic hemangioma is a benign vascular lesion first described by Santa Cruz and Aaronburg. It classically presents as a single, small, red/brown, targetoid lesion on the trunk or extremities of a young or middle-aged individual. Histologically, it is characterized by ectatic vascular lumina in the papillary dermis lined by a single layer of endothelial cells with an epithelioid or "hobnail" appearance. In the deeper dermis, vascular spaces become slit-like and angulated, appearing to dissect through collagen bundles. A commonly proposed etiology of THH is trauma to a preexisting hemangioma. This case is remarkable for its unusual clinical presentation, histologic simulation of THH, and for its support for the theory that trauma can induce the histologic changes seen in THH. PMID:11391103

Christenson, L J; Stone, M S

2001-06-01

105

Intraneural hemangioma of the median nerve: A case report  

PubMed Central

Hemangiomas of the median nerve are very rare and, so far, only ten cases of intraneural hemangioma of this nerve have been reported in the literature. We present a case of 14-year-old girl who had a soft tissue mass in the region of the left wrist with signs and symptoms of carpal tunnel syndrome. Total removal of the mass was achieved using microsurgical epineural and interfasicular dissection. The symptoms were relieved completely, after this procedure, without any neurologic deficit. On follow-up two years later, no recurrence was observed. Whenever a child or young adult patient presents with CTS the possibility of a hemangioma involving the median nerve should be kept in mind in the differential diagnosis. PMID:18294368

2008-01-01

106

MRI diagnosis and preoperative evaluation for pure epidural cavernous hemangiomas  

Microsoft Academic Search

Introduction  The aims of the study were to summarize the characteristics of the spinal epidural cavernous hemangioma, especially for the\\u000a MRI, and to improve the accurate rate of the preoperative diagnosis.\\u000a \\u000a \\u000a \\u000a Methods  The clinical and medical imaging data of six patients with pure spinal epidural cavernous hemangioma proved by operation and\\u000a pathology were analyzed retrospectively.\\u000a \\u000a \\u000a \\u000a Results  The level was thoracic (n?=?2), thoracolumbar (n?=?1),

Jie Feng; Yi-Kai Xu; Long Li; Rui-Meng Yang; Xiang-Hua Ye; Nan Zhang; Tian Yu; Bing-Quan Lin

2009-01-01

107

[Infantile hemangioma and propranolol: a therapeutic "revolution". Literature review].  

PubMed

Infantile hemangioma (IH) is the most common benign vascular tumour affecting children. Most infantile hemangiomas are self-limiting, but some require specific treatment. Propranolol has been proposed for the treatment of infantile hemangiomas. The aim of this study is to explore the mechanism of action of propranolol for the treatment of infantile hemangiomas and to demonstrate its safety and efficacy through a review of the literature. The non cardioselective bêta-blocker propranolol has been used in a pediatric setting for 40 years and, since 2008, has a new indication. A clearly significant improvement has been observed in the condition of children with complicated IH (10%) treated with propranolol. This new indication has been widely described in the international literature. Various explanations have been put forward for the mechanism of action including a vasoconstrictor, antiangiogenic and apoptotic effect of propranolol on the different cells making up an IH. Overall tolerance is good and the efficacy markedly superior to that of any other treatments used for this purpose. In conclusion, with its good tolerance profile and superior efficacy versus all the other available therapies, propranolol can be considered to be a first-line treatment for complicated IH. PMID:24505868

Yilmaz, L; Dangoisse, C; Semaille, P

2013-01-01

108

Infantile hemangioma: pulsed dye laser versus surgical therapy  

NASA Astrophysics Data System (ADS)

Hemangioma is a mesenchymal benign tumor formed by blood vessels. Anomalies affect up to 10% of children and they are more common in females than in males. The aim of our study was to compare the treatment efficacy, namely the curative effect and adverse events, such as loss of pigment and appearance of scarring, between classical surgery techniques and laser techniques. For that reason a group of 223 patients with hemangioma was retrospectively reviewed. For treatment, a pulsed dye laser (PDL) (Rhodamine G, wavelength 595 nm, pulsewidth between 0.45 and 40 ms, spot diameter 7 mm, energy density 9–11 J cm?2) was used and the results were compared with a control group treated with classical surgical therapy under general anesthesia. The curative effects, mainly number of sessions, appearance of scars, loss of pigment, and relapses were evaluated as a marker of successful treatment. From the results it was evident that the therapeutic effects of both systems are similar. The PDL was successful in all cases. The surgery patients had four relapses. Classical surgery is directly connected with the presence of scars, but the system is safe for larger hemangiomas. It was confirmed that the PDL had the optimal curative effect without scars for small lesions (approximately 10 mm). Surgical treatment under general anesthesia is better for large hemangiomas; the disadvantage is the presence of scars.

Remlova, E.; Dostalova, T.; Michalusova, I.; Vranova, J.; Jelinkova, H.; Hubacek, M.

2014-05-01

109

Hemangioma from head to toe: MR imaging with pathologic correlation.  

PubMed

Hemangioma is a common benign vascular neoplasm that closely resembles normal vessels and can be found in all organs of the human body. Vascular lesions can be classified as infantile hemangiomas or vascular malformations on the basis of their natural history, location, cellular turnover, and histologic characteristics. The magnetic resonance (MR) imaging features of vascular malformations of the central nervous system depend on the pathologic subtype. Soft-tissue vascular malformations can be categorized with combined MR imaging and MR angiography as either high- or low-flow. Osseous vascular malformations commonly demonstrate a high-signal-intensity trabecular pattern at both T1- and T2-weighted MR imaging. A group of more aggressive vascular neoplasms, including hemangioendothelioma, hemangiopericytoma, and glomus tumor, have a nonspecific appearance at MR imaging. In the liver and spleen, hemangiomas are typically hyperintense at T2-weighted MR imaging, with a centripetal filling pattern after administration of gadopentetate dimeglumine. Vascular lesions can involve several organs or systems in angiomatous syndromes. MR imaging allows characterization of a hemangioma with typical features, which vary depending on anatomic location. Familiarity with these features facilitates diagnosis and management of these anomalies. PMID:15026587

Vilanova, Joan C; Barceló, Joaquim; Smirniotopoulos, James G; Pérez-Andrés, Ricard; Villalón, Miguel; Miró, Josefina; Martin, Ferran; Capellades, Jaume; Ros, Pablo R

2004-01-01

110

Induction of apoptosis in infantile hemangioma endothelial cells by propranolol.  

PubMed

Propranolol, a non-selective ?-blocker, is emerging as an effective treatment for complicated hemangiomas. The aim of this study was to investigate the molecular mechanism(s) underlying the therapeutic effects of propranolol against hemangiomas, using primary infantile hemangioma endothelial cells (IHECs). IHECs were treated with various concentrations of propranolol and morphological changes and apoptosis were assessed. Changes in the expression levels of apoptosis-related genes were examined. Annexin-V staining revealed that propranolol at 40, 50 and 60 ?g/ml caused a concentration-dependent increase in the apoptosis of IHECs. Morphological analyses revealed that exposure to 50 ?g/ml propranolol resulted in typical apoptotic changes, including shrinkage, the formation of apoptotic bodies and retention of plasma membrane integrity. Gene expression analyses revealed that propranolol treatment led to a marked increase in the expression of caspase-8, cytochrome c, apoptosis-inducing factor, caspase-3 and poly (ADP-ribose) polymerase 1, as well as a concomitant reduction in lamin B1 expression. Our data collectively demonstrate that propranolol induces apoptosis of IHECs through activation of the intrinsic and extrinsic apoptotic pathways, which represents an important mechanism for its therapeutic effects against infantile hemangiomas. PMID:24137229

Tu, Jun-Bo; Ma, Rui-Zhao; Dong, Qiang; Jiang, Fei; Hu, Xiao-Yi; Li, Quan-Yan; Pattar, Parukjan; Zhang, Hao

2013-08-01

111

Periocular capillary hemangioma: management practices in recent years  

PubMed Central

Purpose To present a case series on the management options for capillary hemangiomas involving the eyelid and orbit. Methods This is a retrospective chart review of clinically diagnosed capillary hemangioma cases involving the periocular region treated at two local eye institutions. The patients’ demographics and clinical presentation – including visual acuity, refractive error, periorbital and orbital examinations, and ultrasound and magnetic resonance imaging findings – were reviewed. The clinical progression, modalities of treatment, and treatment outcomes were studied. Results Sixteen cases of capillary hemangiomas involving the eyelid and orbit were studied. The mean age at consultation was 9.6 months (range: 1 month–72 months). The majority were females (75%), with 50% presenting as upper-eyelid hemangiomas and the remaining as lower-eyelid (38%) and glabellar (12%) lesions. Combined superficial and deep involvement was common (64%). Cases whose lesions were located at the upper eyelid or superior orbit led to amblyopia (25%). Fifty-six percent of cases (9/16) were managed conservatively, and 44% (7/16) underwent treatment with either single-agent (n = 4) or combined treatments (n = 3). Conclusion Close monitoring of visual development and prompt institution of amblyopia therapy for children with periocular capillary hemangiomas generally preserve vision. Extensive lesions that affect the visual axis require local and systemic treatments, alone or in combination, in order to reduce the size and impact of lesions on the eyeball, to reduce induced refractive error and visual occlusion, and to prevent the development of amblyopia, in order to achieve good visual outcomes. PMID:23814460

Hernandez, Jo Anne; Chia, Audrey; Quah, Boon Long; Seah, Lay Leng

2013-01-01

112

Intraosseous Hemangioma of the Middle Turbinate Misdiagnosed As a Nasal Polyp  

PubMed Central

Intraosseous hemangiomas account for 1% of all bone tumors and primarily originate from the vertebral column and skull bones. However, intraosseous hemangiomas of the nasal cavity are extremely rare. Here, we report a case of intraosseous hemangioma with a cavernous pattern arising from the middle turbinate that was preoperatively misdiagnosed as chronic rhinosinusitis with polyps. Except for nasal obstruction, there were no specific rhinologic symptoms. The tumor was excised en bloc by the endoscopic endonasal approach without preoperative embolization. PMID:25165592

Lim, Eun Jung; Lee, Jin Gul; Han, Man-Hoon

2014-01-01

113

Painful erections secondary to rare epithelioid hemangioma of the penis  

PubMed Central

Epithelioid hemangioma is a rare benign vascular tumour that atypically involves the penis and usually presents as a painful nodule. A 35-year-old man presented with a 5-month history of painful erections without a clinically apparent lesion or deformity. Magnetic resonance imaging (MRI) with pharmacologically induced erection demonstrated a 1.3-cm nodular lesion deep to the skin at the base of his penis. Following local excision of the lesion, which was diagnosed as an epithelioid hemangioma, the patient was symptom free. This case demonstrates a rare etiology of painful erections with a unique presentation. To the authors’ knowledge, it is also the first report of MRI with intracavernosal injection of trimix to assess for a specific cause of painful erections. PMID:25295139

Barber, Evan; Domes, Trustin

2014-01-01

114

Beta-blockers as therapy for infantile hemangiomas.  

PubMed

Infantile hemangiomas (IH) are common benign vascular tumors seen in children. Although the majority will improve spontaneously without treatment, a small subset will require therapy due to a variety of complications. Less than a decade ago, propranolol replaced corticosteroids as first-line treatment for most IH and it has proven to be a relatively safe, effective therapy. After initiation of propranolol, most hemangiomas show evidence of significant improvement relatively rapidly, often within days. Although propranolol is generally felt to have a more limited side-effect profile than systemic corticosteroids, its use has been infrequently associated with adverse events, including sleep disturbances, acrocyanosis, hypotension, bradycardia, respiratory events, and hypoglycemia. Rarely, hypoglycemic seizures have been reported, usually occurring in the setting of prolonged fasting. PMID:25045334

Nguyen, Harrison P; Pickrell, Brent B; Wright, Teresa S

2014-05-01

115

Spinal lobular capillary hemangioma with an intramedullary component.  

PubMed

Capillary hemangiomas are benign vascular neoplasms rarely involving the spinal cord, where their usual location is extramedullary. A 59-year-old man presented with a 7-month history of progressive numbness which began in the left lower extremity and progressed across the lower back, right flank, trunk and into the right lower extremity with associated pressure and pain in his lower back. On magnetic resonance imaging, there was an avidly-enhancing thoracic intradural lesion that contained an extramedullary intradural component posteriorly, with an apparent intramedullary component anteriorly. Laminectomy of T7 - 8 was performed, and intradural exploration revealed a highly vascular-appearing tumor below the arachnoid, which was not completely dissected because it was densely adherent to the spinal cord. The pathological diagnosis was lobular capillary hemangioma with extra- and intramedullary components. We suggest this lesion should be considered in the differential diagnosis of spinal cord tumors with an intramedullary component. PMID:23924752

Gonzalez, Ricardo; Spears, Julian; Bharatha, Aditya; Munoz, David G

2014-01-01

116

Cavernous hemangioma of the tongue: A rare case report  

PubMed Central

Hemangiomas are developmental vascular abnormalities and more than 50% of these lesions occur in the head and neck region, with the lips, tongue, buccal mucosa, and palate most commonly involved. They are considered as hamartomas rather than true neoplasms. Here we report a case of hemangioma of the body of the tongue, discussing the diagnostic aspects and treatment modalities of such lesion and emphasizing the role of the color Doppler ultrasonography, especially in the diagnosis and treatment. Factors such as patient's age, size and site of lesion and the proximity of lesion to vital structure are paramount in the determination of the therapeutic approach and surgical excision. Even though radiotherapy, cryotherapy, laser therapy, medical treatment, injection of sclerosing substances and the selective embolization of the lingual artery seem to have some efficacy, the author conclude that surgery is the therapy of choice in the isolated vascular lesions of the body of the tongue. PMID:24808705

Kamala, K. A.; Ashok, L.; Sujatha, G. P.

2014-01-01

117

Treatment of infantile subglottic hemangioma. A report of 49 cases.  

PubMed

Forty-nine laryngeal subglottic hemangiomas were observed in infants over a 9-year period. The diagnosis was always confirmed by direct laryngoscopy. The outcome of 42 of these hemangiomas was studied. A total of 26 infants recovered completely after medical treatment and 16 were intubated; only 4 underwent a tracheostomy. Short-term steroid therapy was sufficient in 7 infants, but long-term administration of corticosteroids was necessary in 14 cases. In 10 of the 16 intubated cases it was possible to withdraw corticosteroids permanently. Of the 6 remaining cases, 32P contact radiation therapy was tried in 2 cases of which one was successful, CO2 laser in 2 cases without success, tracheostomy alone in one case and one child died 2 months after extubation, without dyspnea. This series leads us to recommend corticosteroids as a first therapeutic step and short-term nasotracheal intubation if unsuccessful. PMID:4030237

Narcy, P; Contencin, P; Bobin, S; Manac'h, Y

1985-07-01

118

Benefits of the CO2 laser in oral hemangioma excision.  

PubMed

Twenty-one patients with small localized oral cavity hemangiomas of the lips, tongue, and buccal mucosa are reported in this series. Although the lesions were not massive or high-flow/high-pressure vascular tumors, the simultaneous cutting and coagulation capabilities of the CO2 laser were demonstrated, rendering such excisional surgery more precisely and easily accomplished with a great deal less bleeding and a marked reduction in postoperative pain and edema. Many of the patients in this series were done as outpatients under local anesthesia. Results were acceptable and complications were minimal. Thus this laser is recommended both for the patient care and comfort aspects and the ability to render oral cavity hemangioma excisional surgery much more safely and easily done with a significant decrease in hospital utilization and overall medical expenses. PMID:3917570

Apfelberg, D B; Maser, M R; Lash, H; White, D N

1985-01-01

119

Bilateral episcleral brachytherapy in simultaneous choroidal melanoma and circumscribed hemangioma  

PubMed Central

Purpose To describe the efficacy of episcleral brachytherapy in a choroidal melanoma and circumscribed hemangioma arising in both eyes of the same patient. Case report We present the case of a 47 year old man who presented decreased visual acuity a few months preceding initial consult. On fundoscopy, he presented a melanotic lesion in the right eye, and a red-orange choroidal mass in the macular area of the left eye. Material and methods B scan-ultrasound, fluorescein, and indocyanine green angiography, confirmed the diagnosis of choroidal melanoma in the right eye, and circumscribed choroidal hemangioma in the left eye. Episcleral brachytherapy with 125I was performed in both eyes consecutively. Results and Conclusions Bilateral episcleral brachytherapy successfully treated both tumors, preserving the eyes and useful visual function. PMID:24474976

Saornil, María Antonia; García-Álvarez, Ciro; Martín, Francisco Lopez-Lara; Frutos-Baraja, Jesus María

2013-01-01

120

Breast hemangioma with difficulty in preoperative diagnosis: a case report.  

PubMed

We report a rare case of breast hemangioma found in a 70-year-old Japanese female. Before seeking medical attention, the patient noticed a hard mass in her right breast but denied associated symptoms. A mammography revealed a well-circumscribed, highly dense, lobular nodule located in the middle inter portion of the right breast. To verify this finding, we used ultrasonography which revealed an irregular, iso-echoic nodule measuring 10 mm in the same portion. Based on these findings, we suspected a malignancy and performed a core needle biopsy. Unexpectedly, a histological examination of the biopsy displayed normal vasculature, adipose, and mammary tissues. In order to make an accurate diagnosis, the mass was surgically excised under general anesthesia and sent to pathology. Pathological findings of the mass were positive for breast hemangioma, and the patient has had no recurrence of the disease for the past 24 months. PMID:25312096

Funamizu, Naotake; Tabei, Isao; Sekine, Chikako; Fuke, Azusa; Yabe, Mitsuo; Takeyama, Hiroshi; Okamoto, Tomoyoshi

2014-01-01

121

Hemangiomas and Vascular Malformations: Current Theory and Management  

PubMed Central

Vascular anomalies are a heterogeneous group of congenital blood vessel disorders more typically referred to as birthmarks. Subcategorized into vascular tumors and malformations, each anomaly is characterized by specific morphology, pathophysiology, clinical behavior, and management approach. Hemangiomas are the most common vascular tumor. Lymphatic, capillary, venous, and arteriovenous malformations make up the majority of vascular malformations. This paper reviews current theory and practice in the etiology, diagnosis, and treatment of these more common vascular anomalies. PMID:22611412

Richter, Gresham T.; Friedman, Adva B.

2012-01-01

122

Laser treatment of complicated head and neck hemangiomas in infancy.  

PubMed

A retrospective study of 73 patients treated for symptomatic hemangiomas of head and neck from May 1981 to April 1994 was conducted. Fifty-three females and 20 males ranging in age from 1 day of life to 11 years with the average age being 19 months were reviewed in the University of California, Irvine Medical Center. All patients were referred by pediatricians or family practitioners for evaluation and possible laser treatment. The lesions reported were particular troublesome because of obstruction of orifice(s), repeated ulceration, bleeding, subsequent pain or life threatening. Various lasers have been used for these patients including: CO2 laser [10], Argon laser/with intralesional steroid injection [33/14], Nd YAG laser [21], KTP laser [1] and Flashlamp-pumped pulsed dye laser (FPPDL)[8]. All treated lesions healed in 7 to 21 days (mean, 12 days). Complications associated with laser treatment, such as postoperative bleeding and infection were not seen. The symptoms were totally relieved from 7 days to 24 months (mean, 9 months). Combined with reconstructive surgery, the texture changes (7 patients) after laser treatment were corrected successfully. The outcome was graded by reduction in volume, improvement of color and texture of hemangioma as follow: Grade 1 - Poor (0-25%); Grade II - Fair (26-50%); Grade III - Good (51-75%); Grade IV - Excellent (76-100%). The final results of the patients are similar to what may be expected after spontaneous involution of a complicated hemangioma. In summary, complicated hemangiomas of head and neck in infancy have significant morbidity that can be efficiently avoided with the use of laser therapy. PMID:8828255

Chang, C J; Achauer, B M; Vander Kam, V M

1996-06-01

123

Segmental ulcerated perineal hemangioma of infancy: a complex case of PELVIS syndrome successfully treated using a multidisciplinary approach.  

PubMed

We report a case of PELVIS (perineal hemangioma, external genital malformations, lipomyelomeningocele, vesicorenal abnormalities, imperforate anus and skin tag) syndrome in which hemangioma in the perineal area was misdiagnosed at birth as diaper rash. Investigations revealed associated vesicorenal and spinal abnormalities. We emphasize careful diagnosis of suspicious lesions at birth and confirm the successful use of propranolol in treating ulcerated segmental hemangiomas. PMID:23278237

Kaushik, Shivani B; Kwatra, Shawn G; McLean, Thomas W; Powers, Alexander; Atala, Anthony J; Yosipovitch, Gil

2013-01-01

124

Capillary Hemangioma of the Middle Ear: One Case Report and Review of the Literature  

PubMed Central

Hemangiomas are rare benign vascular tumors; there are several types including the capillary hemangiomas, we present the case of an exceptional localization of capillary hemangioma in the middle ear. We report the case of a 60-year-old female which consults for episodes of pulsatile tinnitus, otorragies, and hearing loss of the left ear. The clinical examination revealed a reddish polypoid mass in the left external auditory canal, the radiological tests showed a vascular mass in the middle left ear. The tumor was surgically removed, the histological study revealed a capillary hemangioma. The incidence of hemangiomas in the temporal bone, especially in the middle ear, is exceptional. Medical imaging guides to the vascular nature of these tumors that make confusion with other vascular tumors such as tympanic paragangliomas. The management is often surgical and the final diagnosis is histological. PMID:22953107

Nouri, H.; Harkani, A.; Elouali Idrissi, M.; Rochdi, Y.; Aderdour, L.; Oussehal, A.; Raji, A.

2012-01-01

125

A practical guide to treatment of infantile hemangiomas of the head and neck  

PubMed Central

Infantile hemangiomas are the most common benign vascular tumors in infancy and childhood. As hemangioma could regress spontaneously, it generally does not require treatment unless proliferation interferes with normal function or gives rise to risk of serious disfigurement and complications unlikely to resolve without treatment. Various methods for treating infant hemangiomas have been documented, including wait and see policy, laser therapy, drug therapy, sclerotherapy, radiotherapy, surgery and so on, but none of these therapies can be used for all hemangiomas. To obtain the best treatment outcomes, the treatment protocol should be individualized and comprehensive as well as sequential. Based on published literature and clinical experiences, we established a treatment guideline in order to provide criteria for the management of head and neck hemangiomas. This protocol will be renewed and updated to include and reflect any cutting-edge medical knowledge, and provide the newest treatment modalities which will benefit our patients. PMID:24260591

Zheng, Jia Wei; Zhang, Ling; Zhou, Qin; Mai, Hua Ming; Wang, Yan An; Fan, Xin Dong; Qin, Zhong Ping; Wang, Xv Kai; Zhao, Yi Fang

2013-01-01

126

Hepatitis B  

MedlinePLUS

... of the liver due to infection with the hepatitis B virus (HBV). Other types of viral hepatitis include: Hepatitis ... Hepatitis B infection is caused by the hepatitis B virus (HBV).You ... or body fluids (such as semen, vaginal fluids, and saliva) of a ...

127

Hepatitis B  

MedlinePLUS

... is a serious liver infection caused by the hepatitis B virus. The virus is usually spread from person to ... Hepatitis B is caused by infection with the hepatitis B virus. You can get the virus if you have ...

128

Giant Planets  

E-print Network

We review the interior structure and evolution of Jupiter, Saturn, Uranus and Neptune, and giant exoplanets with particular emphasis on constraining their global composition. Compared to the first edition of this review, we provide a new discussion of the atmospheric compositions of the solar system giant planets, we discuss the discovery of oscillations of Jupiter and Saturn, the significant improvements in our understanding of the behavior of material at high pressures and the consequences for interior and evolution models. We place the giant planets in our Solar System in context with the trends seen for exoplanets.

Guillot, Tristan

2014-01-01

129

Pure Spinal Epidural Cavernous Hemangioma with Intralesional Hemorrhage: A Rare Cause of Thoracic Myelopathy  

PubMed Central

Although cavernous hemangiomas occur frequently in the intracranial structures, they are rare in the spine. Most of spinal hemangiomas are vertebral origin and "pure" epidural hemangiomas not originating from the vertebral bone are very rare. Our spinal hemangioma case is extremely rare because of its "pure" epidural involvement and intralesional hemorrhage. A 64-year-old man presented with progressive paraparesis from two months ago. His motor weakness was rated as grade 4/5 in bilateral lower extremities. He also complained of decreased sensation below the T4 sensory dermatome, which continuously progressed to the higher dermatome level. Magnetic resonance imaging demonstrated thoracic spinal tumor at T3-T4 level. The tumor was located epidural space compressing thoracic spinal cord ventrally. The tumor was not involved with the thoracic vertebral bone. We performed T3-5 laminectomy and removed the tumor completely. The tumor was not infiltrating into intradural space or vertebral bone. The histopathologic study confirmed the epidural tumor as cavernous hemangioma. Postoperatively, his weakness improved gradually. Four months later, his paraparesis recovered completely. Here, we present a case of pure spinal epidural cavernous hemangioma, which has intralesional hemorrhage. We believe cavernous hemangioma should be included in the differential diagnosis of the spinal epidural tumors. PMID:25110490

Jang, Donghwan; Kim, Choonghyo; Lee, Seung Jin; Ryu, Young-Joon

2014-01-01

130

Large capillary hemangioma of the temporal bone with a dural tail sign: A case report  

PubMed Central

The present study reports a rare case of large capillary hemangioma of the temporal bone with a dural tail sign. A 57-year-old female presented with pulsatile tinnitus and episodic vertigo associated with a ten-year history of an intermittent faint headache. Magnetic resonance imaging revealed a mass in the right petrous bone, which was hypointense on T1-weighted images and heterogeneously hyperintense on T2-weighted images, and showed a dural tail sign following gadolinium administration. Pre-operatively, this tumor was believed to be a meningioma. During surgery, the vascular tumor was removed by a modified pterional approach. A histopathological examination indicated that the tumor was a capillary hemangioma. Although intraosseous capillary hemangiomas are rare, they most frequently affect the temporal bone. Hemangiomas of the temporal bone may mimic other more common basal tumors. The diagnosis is most often made during surgical resection. The dural tail sign is not specific for meningioma, as it also occurs in other intracranial or extracranial tumors. The treatment of intratemporal hemangiomas is complete surgical excision, with radiotherapy used for unresectable lesions. To the best of our knowledge, the present study is the fourth case of intraosseous intracranial capillary hemangioma, but the largest intratemporal hemangioma to be reported in the literature to date. PMID:24959241

YANG, GUANG; LI, CHENGUANG; CHEN, XIN; LIU, YAOHUA; HAN, DAYONG; GAO, XIN; KAWAMOTO, KEIJI; ZHAO, SHIGUANG

2014-01-01

131

[Laser surgical excision of a hypopharyngeal hemangioma using the CO2/Nd: YAG combination laser].  

PubMed

Hemangiomas of the upper aerodigestive tract may present a therapeutic challenge depending on their size, location and symptoms. We present a rare case of cavernous hemangioma of the aryepiglottic fold applaning in an adult. First symptoms were dysphagia and hoarseness. Surgical removal was performed with a CO2/Nd: YAG combination laser under microscopic control. After a regular postoperative course the patient has remained disease-free after a 2 year follow up period. We suggest the use of the CO2/Nd: YAG combination laser as preferred treatment in cases of exophytic hemangiomas, because of the favorable combination of excision with photocoagulation effects. PMID:7642401

Kornfehl, J; Kontrus, M; Susani, M; Kautzky, M; Bigenzahn, W

1995-06-01

132

Giant Squid  

NSDL National Science Digital Library

How do you get two dead Giant Squid the size of a school bus from a fishing boat in Spain to a museum in Washington, DC, USA? Call in the Navy! Find out how Operation Calamari unfolded and how the museum managed to put their new Giant Squid on display. Also included is a Learn More section that provides background information on the scientists recorded in the podcast, lessons, images, and cool facts.

2009-01-01

133

Diode laser photocoagulation in PHACES syndrome hemangiomas: a case series  

NASA Astrophysics Data System (ADS)

PHACES syndrome is a pediatric syndrome with cutaneous and extra-cutaneous manifestations, such as Posterior fossa defects, Hemangiomas, Arterial lesions, Cardiac abnormalities/aortic coarctation, Eye abnormalities and Sternal cleft. Facial hemangiomas affect the 75% of patients and may arise on the oral mucosa or perioral cutaneous regions. In this study we treated 26 Intraoral Haemangiomas (IH) and 15 Perioral Haemangiomas (PH) with diode laser photocoagulation using a laser of 800+/-10nm of wavelength. For IH treatment an optical fiber of 320 ?m was used, and the laser power was set ted at 4 W (t-on 200 ms / t-off 400ms; fluence: 995 J/cm2). For PH treatment an optical fiber of 400 ?m at the power of 5 W was used (t-on 100 ms / t-off 300 ms; fluence: 398 J/cm2). IH healed after one session (31%), the other (69%) after two sessions of Laser therapy. In each session, only a limited area of the PH was treated, obtaining a progressive improvement of the lesion. Diode laser photocoagulation is an effective option of treatment for IH and PH in patients affected by PHACE because of its minimal invasiveness. Moreover laser photocoagulation doesn't have side effects and can be performed repeatedly without cumulative toxicity. Nevertheless, more studies are required to evaluate the effectiveness of the therapy in mid and long time period.

Romeo, U.; Russo, N.; Polimeni, A.; Favia, G.; Lacaita, M. G.; Limongelli, L.; Franco, S.

2014-01-01

134

Giant Planets  

NASA Astrophysics Data System (ADS)

Beyond the inner solar system's terrestrial planets, with their compact orbits and rock -metal compositions, lies the realm of the outer solar system and the giant planets. Here the distance between planets jumps by an order of magnitude relative to the spacing of the terrestrial planets, and the masses of the giants are one to two orders of magnitude greater than Venus and Earth - the largest terrestrial bodies. Composition changes as well, since the giant planets are largely gaseous, with inferred admixtures of ice, rock, and metal, while the terrestrial planets are essentially pure rock and metal. The giant planets have many more moons than do the terrestrial planets, and the range of magnetic field strengths is larger in the outer solar system. It is the giant planets that sport rings, ranging from the magnificent ones around Saturn to the variable ring arcs of Neptune. Were it not for the fact that only Earth supports abundant life (with life possibly existing, but not proved to exist, in the martian crust and liquid water regions underneath the ice of Jupiter's moon Europa), the terrestrial planets would pale in interest next to the giant planets for any extraterrestrial visitor.

Lunine, J. I.

135

[An intraosseous hemangioma in the perpendicular lamina of the ethmoid bone].  

PubMed

The incidence of intraosseous hemangiomas is very low. Most of them occur in adult females. The mandible,the zygoma,the maxilla, and the frontal and nasal bones are the areas of most frequent localization in the facial region. The intraosseous hemangioma is a benign, slowly growing,bony hard tumor causing facial deformity. It is diagnosed histologically. We report a case of an 18-year-old male with an intraosseous cavernous hemangioma located in the perpendicular lamina of the ethmoid bone. Intraosseous hemangioma often has characteristic signs on a CT scan, with either coarsened trabeculae lying adjacent to the vascular channels or multifocal lytic areas creating a honeycomb pattern. Because of the age of the patient we considered a midline granuloma and a chondrosarcoma. The therapy of choice is surgical excision; radiation is done in exceptional cases only. PMID:12589420

Graumüller, S; Terpe, H; Hingst, V; Dommerich, S; Pau, H W

2003-02-01

136

Laparoscopic partial resection for hemangioma in the third portion of the duodenum.  

PubMed

Benign duodenal tumors are rare and less common than malignant tumors. Furthermore, vascular lesions of the duodenum, including hemangiomas, are rare causes of gastrointestinal bleeding. This report describes a case with bleeding hemangiomas in the third portion of the duodenum and jejunum and their successful treatment using a laparoscopic approach. There is no report of totally laparoscopic resection for tumor in the third portion of duodenum. After performing a laparoscopic Kocher maneuver, the location of the duodenal hemangioma was confirmed by endoscopic and laparoscopic observation. The lesion was excised using ultrasonic coagulating shears and the defect in the duodenal wall was sutured laparoscopically. The hemangioma of the jejunum was treated extracorporeally through a 3.0 cm umbilical incision. The operating time was 241 min and blood loss was negligible. The postoperative course was uneventful. For benign duodenal tumors in the third portion, if endoscopic resection is not adapted, this less invasive technique may be a standard treatment. PMID:25232270

Kanaji, Shingo; Nakamura, Tetsu; Nishi, Masayasu; Yamamoto, Masashi; Kanemitu, Kiyonori; Yamashiita, Kimihiro; Imanishi, Tatsuya; Sumi, Yasuo; Suzuki, Satoshi; Tanaka, Kenichi; Kakeji, Yoshihiro

2014-09-14

137

Laparoscopic partial resection for hemangioma in the third portion of the duodenum  

PubMed Central

Benign duodenal tumors are rare and less common than malignant tumors. Furthermore, vascular lesions of the duodenum, including hemangiomas, are rare causes of gastrointestinal bleeding. This report describes a case with bleeding hemangiomas in the third portion of the duodenum and jejunum and their successful treatment using a laparoscopic approach. There is no report of totally laparoscopic resection for tumor in the third portion of duodenum. After performing a laparoscopic Kocher maneuver, the location of the duodenal hemangioma was confirmed by endoscopic and laparoscopic observation. The lesion was excised using ultrasonic coagulating shears and the defect in the duodenal wall was sutured laparoscopically. The hemangioma of the jejunum was treated extracorporeally through a 3.0 cm umbilical incision. The operating time was 241 min and blood loss was negligible. The postoperative course was uneventful. For benign duodenal tumors in the third portion, if endoscopic resection is not adapted, this less invasive technique may be a standard treatment. PMID:25232270

Kanaji, Shingo; Nakamura, Tetsu; Nishi, Masayasu; Yamamoto, Masashi; Kanemitu, Kiyonori; Yamashiita, Kimihiro; Imanishi, Tatsuya; Sumi, Yasuo; Suzuki, Satoshi; Tanaka, Kenichi; Kakeji, Yoshihiro

2014-01-01

138

Acute Fatal Upper Airway Obstruction from an Occult Cavernous Hemangioma of the Larynx.  

PubMed

A 42-year-old previously well man collapsed while holding his throat. Resuscitation was unsuccessful, and at autopsy, the most significant findings were limited to the larynx, pharynx, and anterior mediastinum where there were multinodular dark blue tumors. Within the larynx, the lower border of the tumor was well demarcated, not extending beyond the vocal cords. A separate large polypoidal tumor mass was attached to the right aryepiglottic fold by a thin fibrous stalk. Histologic examination revealed numerous large, thin-walled cavernous-type vascular spaces typical of a multifocal cavernous hemangioma. Death was due to asphyxiation from obstruction of the upper airways by a cavernous hemangioma of the larynx. Adult laryngeal hemangiomas are rare and are usually supraglottic. This case demonstrates that pedunculated laryngeal cavernous hemangiomas may remain occult until the initiation of an obstructive episode with sudden collapse and death. In such instances, the diagnosis must rely upon an autopsy examination. PMID:25131533

Kiho, Liina; Byard, Roger W

2014-08-14

139

Topical Treatment for Orbital Capillary Hemangioma in an Adult Using a ?-Blocker Solution  

PubMed Central

Purpose To report a case of orbital capillary hemangioma in an adult who was successfully treated with topical timolol maleate 0.5% solution. Methods Case report. Results A 43-year-old female presented both superficial and deep orbital capillary hemangioma. Topical timolol maleate was applied twice daily. The superficial lesions have nearly disappeared after 1 year of treatment. The deeper lesions have also been reduced in size according to MRI. Conclusion We report an adult patient with a relatively large orbital capillary hemangioma who was successfully treated with a topical ?-blocker solution. This treatment might be applicable for orbital capillary hemangiomas, regardless of the patient's age, because of its effectiveness and safety. PMID:24707274

Ohnishi, Ken; Tagami, Mizuki; Morii, Eiichi; Azumi, Atsushi

2014-01-01

140

Diffuse large B-cell lymphoma within a cavernous hemangioma of the cavernous sinus  

Microsoft Academic Search

Cavernous angiomas or hemangiomas and malignant lymphomas rarely involve the cavernous sinus. We report the case of a 72-year-old\\u000a man with right circumorbital pain and right oculomotor nerve dysfunction because of a mass in the right cavernous sinus. It\\u000a was removed via a transsphenoidal approach and histological examination revealed the mass was a cavernous hemangioma containing\\u000a atypical large B cells

Hirofumi Hirano; Yukie Tashiro; Shingo Fujio; Masamichi Goto; Kazunori Arita

141

PHACES syndrome in association with airway hemangioma: First report from Saudi Arabia and literature review  

PubMed Central

“PHACES” is a neurocutaneous syndrome that refers to the following associations: Posterior fossa malformations, Hemangiomas, Arterial malformations, Coarctation of the aorta/Cardiac defects, Eye abnormalities, and Sternal defects. Herein, we report the association of PHACES syndrome with airway hemangioma, a serious association that should not be overlooked. The findings of such an association presented here are the first to be reported from Saudi Arabia. PMID:22347351

Alsuwaidan, Sami N.

2012-01-01

142

COSMC Is Overexpressed in Proliferating Infantile Hemangioma and Enhances Endothelial Cell Growth via VEGFR2  

PubMed Central

Infantile hemangiomas are localized lesions comprised primarily of aberrant endothelial cells. COSMC plays a crucial role in blood vessel formation and is characterized as a molecular chaperone of T-synthase which catalyzes the synthesis of T antigen (Gal?1,3GalNAc). T antigen expression is associated with tumor malignancy in many cancers. However, roles of COSMC in infantile hemangioma are still unclear. In this study, immunohistochemistry showed that COSMC was upregulated in proliferating hemangiomas compared with involuted hemangiomas. Higher levels of T antigen expression were also observed in the proliferating hemangioma. Overexpression of COSMC significantly enhanced cell growth and phosphorylation of AKT and ERK in human umbilical vein endothelial cells (HUVECs). Conversely, knockdown of COSMC with siRNA inhibited endothelial cell growth. Mechanistic investigation showed that O-glycans were present on VEGFR2 and these structures were modulated by COSMC. Furthermore, VEGFR2 degradation was delayed by COSMC overexpression and facilitated by COSMC knockdown. We also showed that COSMC was able to regulate VEGF-triggered phosphorylation of VEGFR2. Our results suggest that COSMC is a novel regulator for VEGFR2 signaling in endothelial cells and dysregulation of COSMC expression may contribute to the pathogenesis of hemangioma. PMID:23424651

Lee, Jian-Jr; Huang, Miao-Juei; Huang, John; Hung, Ji-Shiang; Chen, Ming-Ting; Huang, Min-Chuan

2013-01-01

143

Rapamycin Inhibits Proliferation of Hemangioma Endothelial Cells by Reducing HIF-1-Dependent Expression of VEGF  

PubMed Central

Hemangiomas are tumors formed by hyper-proliferation of vascular endothelial cells. This is caused by elevated vascular endothelial growth factor (VEGF) signaling through VEGF receptor 2 (VEGFR2). Here we show that elevated VEGF levels produced by hemangioma endothelial cells are reduced by the mTOR inhibitor rapamycin. mTOR activates p70S6K, which controls translation of mRNA to generate proteins such as hypoxia inducible factor-1 (HIF-1). VEGF is a known HIF-1 target gene, and our data show that VEGF levels in hemangioma endothelial cells are reduced by HIF-1? siRNA. Over-expression of HIF-1? increases VEGF levels and endothelial cell proliferation. Furthermore, both rapamycin and HIF-1? siRNA reduce proliferation of hemangioma endothelial cells. These data suggest that mTOR and HIF-1 contribute to hemangioma endothelial cell proliferation by stimulating an autocrine loop of VEGF signaling. Furthermore, mTOR and HIF-1 may be therapeutic targets for the treatment of hemangiomas. PMID:22900063

Medici, Damian; Olsen, Bjorn R.

2012-01-01

144

Giant Pandas  

NSDL National Science Digital Library

The Smithsonian Institution National Zoological Park presents this extensive curriculum guide focused on the giant panda, one of the zoo's most famous denizens. Three sets of multidisciplinary lesson plans -- for grades K-4, 5-8, and 9-12 -- "contain all necessary background information and explore giant panda biology, habitat, zoo science, and conservation efforts." For example, the curriculum guide for grades 9-12 includes lesson plans addressing animal behavior and interdependence, the biomes of China, land-use planning, creative writing, and more. Students may also take advantage of the zoo's many other panda-related resources available online.

145

Propranolol treatment of infantile hemangioma endothelial cells: A molecular analysis  

PubMed Central

Infantile hemangiomas (IHs) are non-malignant, largely cutaneous vascular tumors affecting approximately 5–10% of children to varying degrees. During the first year of life, these tumors are strongly proliferative, reaching an average size ranging from 2 to 20 cm. These lesions subsequently stabilize, undergo a spontaneous slow involution and are fully regressed by 5 to 10 years of age. Systemic treatment of infants with the non-selective ?-adrenergic receptor blocker, propranolol, has demonstrated remarkable efficacy in reducing the size and appearance of IHs. However, the mechanism by which this occurs is largely unknown. In this study, we sought to understand the molecular mechanisms underlying the effectiveness of ? blocker treatment in IHs. Our data reveal that propranolol treatment of IH endothelial cells, as well as a panel of normal primary endothelial cells, blocks endothelial cell proliferation, migration, and formation of the actin cytoskeleton coincident with alterations in vascular endothelial growth factor receptor-2 (VEGFR-2), p38 and cofilin signaling. Moreover, propranolol induces major alterations in the protein levels of key cyclins and cyclin-dependent kinase inhibitors, and modulates global gene expression patterns with a particular affect on genes involved in lipid/sterol metabolism, cell cycle regulation, angiogenesis and ubiquitination. Interestingly, the effects of propranolol were endothelial cell-type independent, affecting the properties of IH endothelial cells at similar levels to that observed in neonatal dermal microvascular and coronary artery endothelial cells. This data suggests that while propranolol markedly inhibits hemangioma and normal endothelial cell function, its lack of endothelial cell specificity hints that the efficacy of this drug in the treatment of IHs may be more complex than simply blockage of endothelial function as previously believed. PMID:23170111

STILES, JESSICA; AMAYA, CLARISSA; PHAM, ROBERT; ROWNTREE, REBECCA K.; LACAZE, MARY; MULNE, ARLYNN; BISCHOFF, JOYCE; KOKTA, VICTOR; BOUCHERON, LAURA E.; MITCHELL, DIANNE C.; BRYAN, BRAD A.

2012-01-01

146

Hepatitis B and Hepatitis C in Pregnancy  

MedlinePLUS

... sometimes causes no signs or symptoms. How is hepatitis B virus infection spread? Hepatitis B virus is spread by ... and hepatitis C infections during pregnancy? • How is hepatitis B virus infection spread? • What is acute hepatitis B virus ...

147

Hepatitis C  

MedlinePLUS Videos and Cool Tools

... impairs liver function and may necessitate a liver transplant • 1-5 of persons might die from the ... Hepatitis C is a leading indication for liver transplants. Diagnosis It is often difficult to diagnose hepatitis ...

148

Viral Hepatitis  

MedlinePLUS

... cleaned properly Eating raw shellfish that came from sewage-contaminated water You can get hepatitis B if ... commonly seen in the United States. Hepatitis A prevention Get vaccinated. People with certain risk factors and ...

149

Hepatitis C  

MedlinePLUS

... can't be spread unless a person has direct contact with infected blood. This means a person who ... hepatitis C? Hepatitis C is usually spread through direct contact with the blood of a person who has ...

150

Anterior hepatic transection for caudate lobectomy.  

PubMed

Resection of the caudate lobe (segment I- dorsal sector, segment IX- right paracaval region, or both) is often technically difficult due to the lobe's location deep in the hepatic parenchyma and because it is adjacent to the major hepatic vessels (e.g., the left and middle hepatic veins). A literature search was conducted using Ovid MEDLINE for the terms "caudate lobectomy" and "anterior hepatic transection" (AHT) covering 1992 to 2007. AHT was used in 110 caudate lobectomies that are discussed in this review. Isolated caudate lobectomy was performed on 28 (25.4%) patients, with 11 case (11%) associated with hepatectomy, while 1 (0.9%) was associated with anterior segmentectomy. Complete caudate lobectomy was performed on 82 (74.5%) patients. Hepatocellular carcinoma was observed in 106 (96.3%) patients, while 1 (0.9%) had hemangioma and 3 (2.7%) had metastatic caudate tumors. AHT was used in 108 (98.1%) caudate resections, while AHT associated with a right-sided approach was performed in 2 (1.8%) cases. AHT is recommended for tumors located in the paracaval portion of the caudate lobe (segment IX). AHT is usually a safe and potentially curative surgical option. PMID:19936187

Chaib, Eleazar; Ribeiro, Marcelo A F; Souza, Yngrid Ellyn Dias Maciel de; D'Albuquerque, Luiz Augusto C

2009-01-01

151

Anterior Hepatic Transection for Caudate Lobectomy  

PubMed Central

Resection of the caudate lobe (segment I- dorsal sector, segment IX- right paracaval region, or both) is often technically difficult due to the lobe’s location deep in the hepatic parenchyma and because it is adjacent to the major hepatic vessels (e.g., the left and middle hepatic veins). A literature search was conducted using Ovid MEDLINE for the terms “caudate lobectomy” and “anterior hepatic transection” (AHT) covering 1992 to 2007. AHT was used in 110 caudate lobectomies that are discussed in this review. Isolated caudate lobectomy was performed on 28 (25.4%) patients, with 11 case (11%) associated with hepatectomy, while 1 (0.9%) was associated with anterior segmentectomy. Complete caudate lobectomy was performed on 82 (74.5%) patients. Hepatocellular carcinoma was observed in 106 (96.3%) patients, while 1 (0.9%) had hemangioma and 3 (2.7%) had metastatic caudate tumors. AHT was used in 108 (98.1%) caudate resections, while AHT associated with a right-sided approach was performed in 2 (1.8%) cases. AHT is recommended for tumors located in the paracaval portion of the caudate lobe (segment IX). AHT is usually a safe and potentially curative surgical option. PMID:19936187

Chaib, Eleazar; Ribeiro, Marcelo A F; de Souza, Yngrid Ellyn Dias Maciel; D’Albuquerque, Luiz Augusto C

2009-01-01

152

Low Concentration of Rapamycin Inhibits Hemangioma Endothelial Cell Proliferation, Migration, and Vascular Tumor Formation in Mice  

PubMed Central

Background Vascular endothelial cell excessive proliferation is the main biological behavior of hemangioma. Rapamycin regulates the growth of endothelial cells by inhibiting mammalian target of rapamycin (mTOR). Thus hemangioma accompanied by excessive mTOR activation should be sensitive to rapamycin. We aimed to illustrate the effect of low-concentration rapamycin on hemangioma and provide a safe and effective drug therapy. Methods Mouse hemangioendothelioma endothelial cells and Nu/Nu mice were used. Rapamycin was applied in a concentration from 1 nM to 20 nM. WST-1 cell proliferation and transwell migration assays were used to analyze vascular tumor proliferation and migration in vitro. Xenograft mouse models were used to test vascular tumor growth in vivo. Results Low-concentration rapamycin (1 nM) inhibited hemangioendothelioma endothelial cell proliferation and migration in vitro and vascular tumor growth in vivo. The mechanism was decreased activation of the protein kinase B/mTOR/S6 ribosomal protein (S6) signaling pathway. Conclusions Rapamycin used in vitro was analogous to low serum concentration rapamycin (7–16 nM) and also significantly inhibited the growth of hemangioma. These results demonstrate a low-toxic drug therapy for hemangioma and encourage continued development of rapamycin and its analogs for use in vascular tumor therapy. PMID:25408787

Zheng, Ningning; Ding, Xudong; Jahan, Rabita

2014-01-01

153

Multiple cavernous hemangiomas of the skull with dural tail sign: a case report and literature review  

PubMed Central

Background Primary intraosseous cavernous hemangioma is a rare bony tumor. To date, only 9 cases of multiple lesions and 2 cases with a dural tail sign have been reported. Case presentation Here, we present a case of multiple cavernous hemangiomas of the skull with dural tail sign in a 24-year-old man. No abnormalities were observed in the right orbit by craniography, but frontal bone destruction was unintentionally discovered. Computed tomography and magnetic resonance imaging demonstrated multiple intraosseous lesions that destroyed the surrounding bone and intracranial extension. Total resection of the two lesions and cranioplasty were performed. Histological examination confirmed the lesions as a cavernous hemangioma. Conclusion Cavernous hemangioma is a rare bony tumor that should be considered in the differential diagnosis of skull tumors. Resection of all lesions should be performed on patients with multiple cavernous hemangiomas, and these patients should have regular follow-up examinations. Based on this case, and our literature review, we found that outcomes are usually very good. PMID:24161077

2013-01-01

154

Angiosarcoma Arising in a Patient with a 10-Year-Old Hemangioma  

PubMed Central

The transformation of a benign hemangioma into a malignant angiosarcoma has been rarely reported, with only 11 cases reported in the literature. There have been no reports of malignant transformation of hemangioma into angiosarcoma in association with epithelioid hemangioendothelioma, to our knowledge. The existence of precursor malignancies in the tumorigenesis of sarcomas is still not clearly defined. We describe the case of a 40-year-old woman with a preceding history of a suspected hemangioma for ten years, who upon resection was found on histology to have evidence of a hemangioma with an associated area of epithelioid hemangioendothelioma as well as areas of overt high grade epithelioid angiosarcoma. These findings raise the possibility of the evolution of hemangioma to epithelioid hemangioendothelioma, and the latter to overt angiosarcoma. The patient was managed as having a high grade sarcoma with wide resection and radiation. She declined systemic adjuvant chemotherapy after a thorough discussion about the risks and benefits of chemotherapy, and she currently remains disease free one year after the surgery.

Nathenson, Michael J.; Molavi, Diana; Aboulafia, Albert

2014-01-01

155

[Medication-based therapy of infantile hemangioma and lymphatic malformations].  

PubMed

The therapy of vascular tumors and malformations should be interdisciplinary and performed according to available guidelines. Infantile hemangiomas (IH) are the most frequent vascular tumors of childhood and do not require treatment in most cases. If the IH is complicated by its location (e.g. facial or genital) or if the lesion threatens to cause loss of function, small localized IH should be treated by laser- or cryotherapy. If the IH is diffuse or rapidly growing it can be successfully treated using the ? blocker propranolol. The mechanism underlying the efficacy of this medication-based therapy is not completely understood and this still represents an experimental therapy. The results of molecular studies on vascular malformations have indicated new strategies for medical therapies. However, lymphatic malformations (LM) are still treated by surgery where possible, or sclerotherapy. Further investigations are necessary to determine whether new drugs such as the mTOR inhibitor rapamycin may be effective for treatment of diffuse LM. First case reports seem to be promising. PMID:24434958

Rössler, J; Braunschweiger, F; Schill, T

2014-01-01

156

Late rebound of infantile hemangioma after cessation of oral propranolol.  

PubMed

Propranolol has become the first line of treatment for infantile hemangiomas (IHs), with a high response rate, but rebound growth after cessation of propranolol has been reported, primarily in the first year of life. We sought to determine the frequency and associated factors leading to late regrowth after successful treatment at an age when the proliferative phase has usually ceased. We retrospectively reviewed the clinical charts, serial photographs, and radiologic images of children with rebound IH occurring after the age of 15 months after a successful course of oral propranolol averaging 2.6 mg/kg/day (range 2-3 mg/kg/day). Thirteen (10 female, 3 male) of 212 patients (6%) treated with oral propranolol since 2008 were evaluated. The mean age at the start of treatment was 5.3 months (range 1.8-13 months), and an average of 10.3 months (range 4.5-16 months) of treatment was given. It took an average of 5.3 months (range 1-13.8 months) for a significant rebound to appear. Late rebound after successful propranolol indicates a prolonged proliferation phase of IH even after 15 months of age. This is compared with previous reports of rebound, which occurred primarily in infants younger than 1 year old. Late proliferation can occur in localized, small, mixed, and deep IH, even after several months of a positive response to propranolol. A second course of propranolol readily controlled the recurrence. PMID:24016283

Shehata, Nancy; Powell, Julie; Dubois, Josée; Hatami, Afshin; Rousseau, Elizabeth; Ondrejchak, Sandra; McCuaig, Catherine

2013-01-01

157

Endoscopic endonasal removal of a cavernous hemangioma of the orbital apex  

PubMed Central

Background: Cavernous hemangioma are the most common benign lesions of the orbit. Their surgical resection is still challenging and several surgical approaches have been proposed. Case Description: We present the case of a 59-year-old woman with a cavernous hemangioma of the orbital apex, which was diagnosed incidentally. The hemangioma was extraconal and involved mainly the medial orbital apex; it also extended to the pterygoid fossa, to the middle fossa, to the maxillary and sphenoid sinuses. The surgical resection was performed by a pure endoscopic transphenoidal, transmaxillary, transethmoidal approach, achieving a total removal. The patient had a transient and incomplete paresis of the VI cranial nerve on the left side and did not experience other postoperative complications. Conclusion: The endoscopic endonasal approach proved successful in the management of this case and it should be considered in the surgical management of extraconal orbital apex lesions with medial or inferior extension. PMID:21697974

Locatelli, Marco; Carrabba, Giorgio; Guastella, Claudio; Gaini, Sergio M.; Spagnoli, Diego

2011-01-01

158

Laryngeal stenosis following carbon dioxide laser in subglottic hemangioma. Report of three cases.  

PubMed

Recent reports recommend carbon dioxide laser as the safest and the most effective treatment for subglottic hemangioma in infants. Though one report mentions the development of a small amount of subglottic scarring in an 8-month-old girl after resection of a subglottic hemangioma, there is insufficient emphasis in the literature with respect to stenosis as a complication of CO2 laser therapy. The authors present three cases of severe laryngotracheal stenosis developing in infants treated with the CO2 laser for subglottic hemangioma. The presentation of these three cases should be a warning to the otolaryngologist that the use of the CO2 laser is not without significant risk of scar tissue formation. PMID:3931531

Cotton, R T; Tewfik, T L

1985-01-01

159

Defocused Irradiation Mode of Diode Laser for Conservative Treatment of Oral Hemangioma  

PubMed Central

Vascular lesions rise from abnormalities in blood vessels or endothelial proliferation. Capillary hemangiomas are formed by small capillaries surrounded by a layer of endothelial cells in a connective tissue stroma. Various treatments are used for these conditions like excisional surgery, sclerotherapy, and recently laser irradiation. In this case study, we report successful treatment of intraoral capillary hemangioma by gallium/aluminum/arsenide (GaAlAs) laser. A 29 year old woman with a red lesion on the upper side of the right maxillary premolar was referred to private dental office. The Diode laser with wavelength of 810 nm was selected for treatment of the lesion in defocused mode by output power of 4 W in continuous mode. No bleeding was observed during surgery which provided better vision for surgeon and resulted in a minimally invasive procedure. According to results, Diode laser can be considered as a conservative modality in treatment of oral capillary hemangioma, especially in the esthetic zone. PMID:25606323

Fekrazad, Reza; AM Kalhori, Katayoun; Chiniforush, Nasim

2013-01-01

160

Primary spinal epidural cavernous hemangioma: clinical features and surgical outcome in 14 cases.  

PubMed

OBJECT The aim of this study was to investigate the clinical characteristics, imaging features, differential diagnosis, treatment options, and prognosis for primary spinal epidural cavernous hemangiomas. METHODS Fourteen patients with pathologically diagnosed non-vertebral origin cavernous hemangiomas who had undergone surgery at Beijing Tiantan Hospital between 2003 and 2012 were identified in the hospital's database. The patients' clinical data, imaging characteristics, surgical treatment, and postoperative follow-up were analyzed retrospectively. RESULTS There were 9 males and 5 females with an average age of 51.64 years. The primary epidural cavernous hemangiomas were located in the cervical spine (2 cases), cervicothoracic junction (2 cases), thoracic spine (8 cases), thoracolumbar junction (1 case), and lumbar spine (1 case). Hemorrhage was confirmed in 4 cases during surgery. Preoperatively 5 lesions were misdiagnosed as schwannoma, 1 was misdiagnosed as a meningioma, and 1 was misdiagnosed as an arachnoid cyst. Preoperative hemorrhages were identified in 2 cases. Three patients had recurrent cavernous hemangiomas. The initial presenting symptoms were local pain in 5 cases, radiculopathy in 6 cases, and myelopathy in 3 cases. Upon admission, 1 patient had radicular symptoms and 13 had myelopathic symptoms. The average symptom duration was 18 months. All patients underwent surgery; complete resection was achieved in 8 cases, subtotal resection in 4 cases, and partial resection in 2 cases. Postoperative follow-up was completed in 10 cases (average follow-up 34 months); 1 patient died, 5 patients showed clinical improvement, and 4 patients remained neurologically unchanged. CONCLUSIONS Total surgical removal of spine epidural cavernous hemangiomas with a chronic course is the optimum treatment and carries a good prognosis. Secondary surgery for recurrent epidural cavernous hemangioma is technically more challenging. In patients with profound myelopathy from acute hemorrhage, even prompt surgical decompression can rarely reverse all symptoms. PMID:25343406

Li, Teng-Yu; Xu, Yu-Lun; Yang, Jun; Wang, James; Wang, Gui-Huai

2015-01-01

161

Lobular Capillary Hemangioma of the Nasal Cavity: A Retrospective Study of 15 Cases in Taiwan  

PubMed Central

Background: Lobular capillary hemangioma of the nasal cavity is an uncommon benign vascular tumor of unknown etiology. There have been only very few case reports in Taiwan. Aims: This study aimed to analyze the clinical features, radiological findings, treatment modalities, and outcome of lobular capillary hemangioma treated at a teaching hospital in Taiwan during a period of 10 years. Study Design: Descriptive study. Methods: Retrospective chart reviews were performed on patients who were diagnosed with lobular capillary hemangioma of the nasal cavity at Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan, from January 2003 to December 2012. Data retrieved included age, gender, clinical symptoms, computed tomography (CT) findings, treatment modalities, and outcome for further analysis. Results: Of the 15 patients identified, there were five males and ten females ranging from 17 to 86 years of age, with a mean age of 43.8±20.2. Epistaxis was the most common presenting symptom. All patients presented a unilateral nasal lobular capillary hemangioma. The most commonly affected site was the anterior nasal septum, followed by the inferior turbinate, vestibule, middle turbinate, and posterior nasal septum. All lesions presented as soft tissue density without bony erosions under CT examination. Endoscopic excisional surgery (n=12) or classical local excision (n=3) was performed for complete removal of the hemangioma. No evidence of recurrence was observed with 6 to 75 months of follow-up. Conclusion: Lobular capillary hemangioma of the nasal cavity was usually found to occur in anterior septum with epistaxis. Complete excision with endoscopic surgery or classical local excision was recommended and recurrence can be prevented. PMID:25207171

Chi, Tzu-Hang; Yuan, Chien-Han; Chien, Shang-Tao

2014-01-01

162

Hemangioma of the cervix managed with the Nd:YAG laser.  

PubMed

A large hemangioma of the cervix was treated successfully with the neodymium:yttrium-aluminum-garnet (Nd:YAG) laser. A survey of the literature disclosed 39 cases of hemangioma of the cervix and vagina. Hysterectomy was the primary mode of therapy in 15 cases. More conservative approaches have been used in young women requesting preservation of their childbearing ability, including CO2 laser excision, knife excision, cryotherapy, and electrocauterization. In the case presented, the Nd:YAG laser was used in the non-contact mode for a photocoagulative effect. This technique results in destruction of the lesion with less danger of bleeding than with any other surgical technique. PMID:1923239

Powell, J L; Zwirek, S J; Sankey, H Z

1991-11-01

163

An unusual cause of dyspnea in a pregnant woman: supraglottic hemangioma.  

PubMed

Dyspnea is a common complaint among pregnant women; upper airway obstruction is a rare cause of it. We report a case of supraglottic hemangioma in a 20-year-old pregnant woman who presented with increasing dyspnea and hoarseness at 40 weeks of gestation. She gave birth to a healthy 3,100-g girl by caesarean delivery under epidural anesthesia. She was able to breathe easily during the postpartum period. This case represents a rare instance of dyspnea caused by a supraglottic hemangioma in a pregnant woman. PMID:25181668

Kurdoglu, Zehra; Kurdoglu, Mertihan; Cankaya, Hakan

2014-08-01

164

Acute carpal tunnel syndrome due to a hemangioma of the median nerve  

PubMed Central

Hemangioma of the median nerve presenting as acute carpal tunnel syndrome is unusual A-18- year old male presented with severe incapacitating pain of sudden onset of left forearm and hand after manual field work. There was swelling on volar aspect of forearm, with hyperalgesia in the median nerve distribution. The fingers and wrist were inmarked flexion and the patient did not allow wrist and finger extension. X-rays were within normal limits. An emergency volar carpal ligament release revealed, haematoma about 100 ml with numerous vessels encircling the median nerve. Histopathology of lesion turned out to be a cavernous hemangioma. Post operatively patient had full recovery. PMID:21124689

Meena, DS; Sharma, Mrinal; Sharma, CS; Patni, Purnima

2007-01-01

165

Hepatitis B  

MedlinePLUS

... A Hepatitis B HPV (Human Papillomavirus) Influenza (Flu) Measles Meningococcal Disease Mumps Pertussis (Whooping Cough) Pneumococcal Disease Rubella (German Measles) Shingles (Herpes Zoster) Tetanus (Lockjaw) Professional Resources Adult ...

166

Role of diffusion-weighted magnetic resonance imaging in the differential diagnosis of focal hepatic lesions  

PubMed Central

AIM: To evaluate the utility of diffusion-weighted imaging (DWI) in screening and differential diagnosis of benign and malignant focal hepatic lesions. METHODS: Magnetic resonance imaging (MRI) examinations were performed using the Signa Excite Xl Twin Speed 1.5T system (GE Healthcare, Milwaukee, WI, USA). Seventy patients who had undergone MRI of the liver [29 hepatocellular carcinomas (HCC), four cholangiocarcinomas, 34 metastatic liver cancers, 10 hemangiomas, and eight cysts] between April 2004 and August 2008 were retrospectively evaluated. Visualization of lesions, relative contrast ratio (RCR), and apparent diffusion coefficient (ADC) were compared between benign and malignant lesions on DWI. Superparamagnetic iron oxide (SPIO) was administered to 59 patients, and RCR was compared pre- and post-administration. RESULTS: DWI showed higher contrast between malignant lesions (especially in multiple small metastatic cancers) and surrounding liver parenchyma than did contrast-enhanced computed tomography. ADCs (mean ± SD × 10-3 mm2/s) were significantly lower (P < 0.05) in malignant lesions (HCC: 1.31 ± 0.28 and liver metastasis: 1.11 ± 0.22) and were significantly higher in benign lesions (hemangioma: 1.84 ± 0.37 and cyst: 2.61 ± 0.45) than in the surrounding hepatic tissues. RCR between malignant lesions and surrounding hepatic tissues significantly improved after SPIO administration, but RCRs in benign lesions were not improved. CONCLUSION: DWI is a simple and sensitive method for screening focal hepatic lesions and is useful for differential diagnosis. PMID:19998501

Koike, Naoto; Cho, Akihiro; Nasu, Katsuhiro; Seto, Kazuhiko; Nagaya, Shigeyuki; Ohshima, Yuji; Ohkohchi, Nobuhiro

2009-01-01

167

Atypical giant haemangioma of liver with systemic inflammatory manifestations  

PubMed Central

Haemangioma is the most common benign tumour of the liver. Most of them are small in size (less than 4?cm) and are often asymptomatic and discovered incidentally on modern diagnostic imaging. Lesions with a diameter larger than 4?cm are called giant haemangiomas, and these are usually located in the right hepatic lobe. Although haemangioma is the most frequent benign tumour of the liver, ‘giant’ haemangiomas are rare. Such lesions may give rise to symptoms requiring treatment. In this case report, we describe the case of a 50-year-old Indian man who presented with giant liver haemangioma and systemic inflammatory manifestations. PMID:23355558

Khalid, Mohd; Ahmad, Mehtab; Jain, Amit; Rizvi, Imran

2013-01-01

168

Identification of Serum Regression Signs in Infantile Hemangioma  

PubMed Central

Vessel proliferation underlies a number of serious pathological conditions. Infantile Hemangioma (IH) is a low-aggressive vascular tumor, interesting as an in vivo model of spontaneous tumor regression. Identifying mechanisms underlying IH spontaneous regression may then help to elucidate vessel-growth control, strongly deregulated in other serious conditions such as sarcoma, melanoma, diabetic retinopathy. The present study was aimed at identifying early regression indicators within hematological parameters. Thirty-four blood samples were collected from IH diagnosed babies (20-months median age), spontaneously regressing with age. Nineteen serum standard blood-tests were carried out using diagnostic reagents; in addition, serum-expression of 27 cytokine/chemokines was measured. Samples were divided in three age-groups, namely ?12, 13 to 24 and >24 months-age, respectively. Red-cells count, Hemoglobin, Hematocrit, Neutrophils, Lymphocytes, MCP-1 and MIP-1beta were significantly different in the three age-groups, according to one-way ANOVA analysis. The same parameters showed a significant Pearson-correlation with age, supporting the direct link of age with IH-regression. ROC analysis showed that red-cells count, Hemoglobin, Hematocrit, MCP-1 and MIP-1beta levels significantly discriminate IH in the proliferating-phase from IH in the regressing-phase. Such data indicate for the first time that standard hematological tests and cytokine serum-expression values may effectively discriminate proliferating- from regressing-IH, unrevealing early regression signs, and demonstrate that standard blood-tests may have novel unsuspected diagnostic/prognostic relevance in altered vessel-growth conditions. PMID:24599340

Rossi, Stefania; Giampietri, Claudia; Facchiano, Francesco; Facchiano, Antonio

2014-01-01

169

Infantile Perianal Pyramidal Protrusion with Coexisting Perineal and Perianal Hemangiomas: A Fortuitous Association or Incomplete PELVIS Syndrome?  

PubMed Central

Two cases of infantile perianal pyramidal protrusions (IPPP), one pyramidal in shape and one leaf shaped, are being described by us. Both were notable for coexisting hemangiomas in the close vicinity. To the best of our knowledge we are reporting these two variants of IPPP with the associated neighboring hemangiomas for the first time in Indian dermatologic literature. We suggest that this presentation may be a part of one of the syndromes that comprise anorectal malformations with hemangiomas like PELVIS syndrome and others mentioned in the table. PMID:24470664

Verma, Shyam B; Wollina, Uwe

2014-01-01

170

Intravascular papillary endothelial hyperplasia (Masson's hemangioma) presenting as a lateral neck mass.  

PubMed

Intravascular papillary endothelial hyperplasia (Masson's hemangioma) is a benign disease of vascular origin characterized by exuberant endothelial proliferation in normal blood vessels.The most important feature of the disease is its resemblance to hemangiosarcoma and the resulting possible radiologic misinterpretation. We present the radiologic findings in a 45-year-old woman presenting a neck mass extending to the thoracic cavity. PMID:19358481

Yücesoy, C; Coban, G; Yilmazer, D; Oztürk, E; Hekimo?lu, B

2009-01-01

171

Management of infantile subglottic hemangioma: laser vaporization, submucous resection, intubation, or intralesional steroids?  

PubMed

The infantile subglottic hemangioma can be treated in various ways. The results of the treatment used in the Sophia Children's Hospital, intralesional steroids and intubation (IS + I), are discussed and compared with the results of other current treatment methods: CO2 laser vaporization, submucous resection and intubation alone. A total of 18 infants were treated for subglottic hemangioma in our hospital: ten with IS + I alone, five were first treated with systemic therapy and later with IS + I alone and three with various therapies. IS + I was effective in 14 of the 15 patients, one patient was lost from follow up. The remaining three infants were treated with (combinations of) various therapies, because IS + I failed or was not tried. Two patients were finally cured, one still has a tracheotomy. Of other current therapies, CO2 laser vaporization is reported to be effective. In all 30% of the infants treated in Boston Children's Hospital with CO2 laser needed a tracheotomy. Moreover subglottic stenosis is a serious complication. Submucous resection is often successful. It may be complicated by subglottic stenosis and in some cases, depending on the localization of the hemangioma, it may be contraindicated. Intubation alone is less effective than intubation combined with intralesional steroids. Management of subglottic hemangioma in Sophia Children's Hospital is primarily intralesional steroids and intubation and secondarily submucous resection or tracheotomy. CO2 laser vaporization is seldom applied because of the risk of subglottic stenosis. PMID:9692627

Hoeve, L J; Küppers, G L; Verwoerd, C D

1997-12-10

172

A rare vascular tumor of the external auditory canal: the capillary hemangioma.  

PubMed

A 32-year-old woman presented to our department with a 10-month history of right-sided intermittant otorrhagia. There was no history of hearing loss or pulsatile tinnitus. Otomicroscopic examination revealed a reddish mass arising from the right antero-superior portion of bony canal wall, which measured about 1 cm in diameter. The tympanic membrane seemed to be uninvolved. A computed tomography scan of the temporal bone showed 0.6 x 0.8 cm diameter soft-tissue mass arising from the right external auditory canal, 0.5 cm away from tympanic membrane. The lesion was excised via a transcanal approach under local anesthesia. The histopathologic assessment indicated a capillary hemangioma. There was no recurrence four years after the surgery. Hemangioma of the external auditory canal is a rare otologic entity. It is commonly classified as capillary or cavernous hemangioma. According to the literature, this case represents the second patient with capillary hemangioma of the external auditory canal. PMID:19860637

Ya?ar, Hüsamettin; Ozkul, Haluk; Somay, Adnan

2009-01-01

173

Cavernous hemangioma of the heart: case report and review of the literature.  

PubMed

A case of diffuse cavernous hemangioma of the heart discovered incidentally during life is reported. Resection of the tumor was impossible at operation. Two similar cases were found in the literature. Radation therapy is suggested, and the importance of a simple blood pool scan in the investigation of paracardiac masses is stressed. PMID:1117732

Tabry, I F; Nassar, V H; Rizk, G; Touma, A; Dagher, I K

1975-03-01

174

Parenteral corticosteroids followed by early surgical resection of large amblyogenic eyelid hemangiomas in infants  

PubMed Central

Background The purpose of this study was to evaluate the results and complications of early surgical resection of large amblyogenic subdermal eyelid hemangiomas in infants after prior short-term parenteral administration of corticosteroids. Methods Sixteen infants were given dexamethasone 2 mg/kg/day in two divided doses for three consecutive days prior to scheduled surgical excision of large eyelid hemangiomas. The lesions were accessed via an upper eyelid crease, subeyebrow incision, or a lower eyelid subciliary incision. Results In all cases, surgical excision of the entire lesion was possible with no significant intraoperative or postoperative complications. The levator muscle/aponeurosis complex was involved in 31.25% of cases and was managed by reinsertion or repositioning without resection. A satisfactory lid position and contour with immediate clearing of the visual axis was achieved in all but one case (93.8%). Conclusion Parenteral corticosteroids helped in reducing volume and blood flow from the hemangiomas, allowing for very early total excision of large subdermal infantile hemangiomas without significant intraoperative hemorrhage. This resulted in immediate elimination of any reason for occlusion amblyopia. Long-term follow-up of visual development in these patients would help to demonstrate the effectiveness of this strategy compared with more conservative measures. PMID:23761960

Essawy, Rania El; Galal, Rasha Essameldin

2013-01-01

175

Cavernous hemangiomas of the liver: Are there any indications for resection  

Microsoft Academic Search

A total of 163 patients with cavernous hemangiomas of the liver were managed at Paul Brousse Hospital between 1970 and 1992. The tumor was smaller than 4 cm in 54 patients and larger than 10 cm in 38 patients. The diagnostic sensitivities of the imaging procedures were as follows: ultrasonography 61%; angio-computed tomography scanning 77%; angiography 85%; magnetic resonance imaging

Olivier Farges; Salam Daradkeh; Henri Bismuth

1995-01-01

176

Hepatic Encephalopathy  

PubMed Central

Chronic liver disease and cirrhosis affect hundreds of millions of patients all over the world. The majority of patients with cirrhosis will eventually develop complications related to portal hypertension. One of these recurrent and difficult to treat complications is hepatic encephalopathy. Studies have indicated that overt hepatic encephalopathy affects 30 to 45% of patients with cirrhosis and a higher percentage may be affected by minimal degree of encephalopathy. All of these factors add to the impact of hepatic encephalopathy on the healthcare system and presents a major challenge to the gastroenterologist, hospitalist and primary care physician. PMID:23006457

Bleibel, Wissam; Al-Osaimi, Abdullah M. S.

2012-01-01

177

[Giant insulinoma].  

PubMed

Islet-cell tumors are the most common neuroendocrine tumors that arise from the endocrine pancreas. They are typically benign and sporadic. Diagnosis is generally established late because clinical signs lack specificity. The insulinoma is difficult to localize since it is very small in size, often not exceeding 2cm. We report an exceptional case of giant insulinoma initially revealed by a pseudo-polycythemia in an 80-year-old man. He had been treated for hypertension for a few months. Routine biological investigations showed elevated hematocrit and haemoglobin, suggesting Vaquez disease. History taking revealed recent episodes of nocturnal agitation. On admission, he had reddish skin with a suspected enlarged spleen, but total blood volume was normal. Imaging studies showed a voluminous tumor located between the pancreas and the spleen. The presence of an insulinoma was confirmed on the basis of an elevated level of proinsulin at the time of an asymptomatic episode of hypoglycemia. Spleno-pancreatectomy was performed. Histopathological examination revealed a malignant, well-differentiated neuroendocrine malignant tumor. PMID:18937931

Ketari-Jamoussi, S; Debbiche-Chedly, A; Ben Dhaou, B; Boussema, F; Cherif, O; Cherif, A R; Ben Ayed, M; Bouzaine, A; Rokbani, L

2009-03-01

178

Hepatic Encephalopathy  

MedlinePLUS Videos and Cool Tools

... is a condition that causes temporary worsening of brain function in people with advanced liver disease. When ... travel through your body until they reach your brain, causing mental and physical symptoms of HE. Hepatic ...

179

Hepatitis C  

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... who had hepatitis C Received a tattoo or acupuncture with needles that were not disinfected properly after ... have a tattoo license or permit or an acupuncture license) Received an organ transplant from a donor ...

180

Hepatitis E  

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... hepatitis E virus is transmitted mainly through contaminated drinking water. It is usually a self-limiting infection and ... faecal-oral route due to faecal contamination of drinking water. Other transmission routes have been identified, which include: ...

181

Hepatitis A  

Microsoft Academic Search

\\u000a Although hepatitis A is arguably among the most ancient of human diseases and among the first to have been recorded by physicians,\\u000a the responsible infectious agent, a unique picornavirus, hepatitis A virus (HAV), was identified less than 40 years ago (Feinstone\\u000a et al. 1973). The discovery of the virus built on decades of previous research led by investigators such as

Leonard N. Binn; Stanley M. Lemon

182

Delta agent (Hepatitis D)  

MedlinePLUS

... is found only in people who carry the hepatitis B virus. HDV may make a recent (acute) hepatitis B ... can even cause symptoms in people who carry hepatitis B virus but who never had symptoms. Hepatitis D infects ...

183

Transforming giants.  

PubMed

Large corporations have long been seen as lumbering, inflexible, bureaucratic--and clueless about global developments. But recently some multinationals seem to be transforming themselves: They're engaging employees, moving quickly, and introducing innovations that show true connection with the world. Harvard Business School's Kanter ventured with a research team inside a dozen global giants--including IBM, Procter & Gamble, Omron, CEMEX, Cisco, and Banco Real--to discover what has been driving the change. After conducting more than 350 interviews on five continents, she and her colleagues came away with a strong sense that we are witnessing the dawn of a new model of corporate power: The coordination of actions and decisions on the front lines now appears to stem from widely shared values and a sturdy platform of common processes and technology, not from top-down decrees. In particular, the values that engage the passions of far-flung workforces stress openness, inclusion, and making the world a better place. Through this shift in what might be called their guidance systems, the companies have become as creative and nimble as much smaller ones, even while taking on social and environmental challenges of a scale that only large enterprises could attempt. IBM, for instance, has created a nonprofit partnership, World Community Grid, through which any organization or individual can donate unused computing power to research projects and see what is being done with the donation in real time. IBM has gained an inspiring showcase for its new technology, helped business partners connect with the company in a positive way, and offered individuals all over the globe the chance to contribute to something big. PMID:18271317

Kanter, Rosabeth Moss

2008-01-01

184

Feature Hepatitis: Hepatitis Symptoms, Diagnosis, Treatment & Prevention  

MedlinePLUS

... Navigation Bar Home Current Issue Past Issues Feature Hepatitis Hepatitis: Symptoms, Diagnosis, Treatment & Prevention Past Issues / Spring 2009 ... No appetite Fever Headaches Diagnosis To check for hepatitis viruses, your doctor will test your blood. You ...

185

Giant Cell Arteritis  

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Giant cell arteritis is a disorder that causes inflammation of arteries of the scalp, neck, and arms. It narrows ... arteries, which keeps blood from flowing well. Giant cell arteritis often occurs with another disorder called polymyalgia ...

186

Primary Intraosseous Cavernous Hemangioma of the Clivus: Case Report and Review of the Literature  

PubMed Central

Primary intraosseous hemangiomas are benign, vascular malformations that account for approximately 1% of all primary bone neoplasms. These tumors are mostly found in vertebral bodies and are rarely seen in the calvarium, where they represent 0.2% of bony neoplasms. When found in the skull, they tend to present with vague symptoms and do not have the typical radiological findings suggestive of hemangiomas. Because of this, these tumors can be missed in many cases or may be misinterpreted as more ominous lesions like multiple myeloma or osteosarcoma. Involvement of the skull base is exceedingly rare, and presentation with cranial nerve unilateral polyneuropathies has not been reported. We report a patient case with review of recent pertinent literature. PMID:23943715

Gologorsky, Yakov; Shrivastava, Raj K.; Panov, Fedor; Mascitelli, Justin; Signore, Anthony Del; Govindaraj, Satish; Smethurst, Mark; Bronster, David J.

2013-01-01

187

Occult androgenetic-biparental mosaicism and sporadic hepatic mesenchymal hamartoma.  

PubMed

The incidence of hepatic mesenchymal hamartoma (HMH) is increased in patients with placental mesenchymal dysplasia (PMD), which appears to be caused by androgenetic-biparental mosaicism (ABM). We hypothesized that occult ABM might underlie cases of HMH with no known history of PMD. Formalin-fixed, paraffin-embedded HMH specimens from 10 such patients and liver specimens from 6 non-HMH controls were identified retrospectively from the surgical pathology records of a pediatric hospital. The relative abundance of maternal and paternal alleles was assessed by quantitative polymerase chain reaction amplification of polymorphic short tandem repeats and single nucleotide polymorphisms located on 15 different chromosomes. Androgenetic-biparental mosaicism was diagnosed in one patient based on global allelic imbalances at all informative loci. In that patient, the greatest imbalances were observed in stroma-rich portions of the hamartoma, with no significant imbalance in histologically normal liver or epithelium-rich portions of the hamartoma. A retrospective, unbiased review of the histology and clinical records from all 10 patients revealed no morphologic or clinical correlates to distinguish the affected patient, except that she had multiple cutaneous hemangiomas, which like HMH, appear to be more common in patients with PMD. Our findings suggest that other patients with apparently sporadic HMH, hemangioma, or other lesions seen more frequently with PMD may harbor occult ABM. Recognition of ABM may be important because its long-term consequences are unknown but may be significant. PMID:21585278

Lin, Jingxian; Cole, Bonnie L; Qin, Xuan; Zhang, Min; Kapur, Raj P

2011-01-01

188

[Use of CO2 laser in the treatment of skin hemangiomas in children].  

PubMed

The use of the CO2-laser in the treatment of hemangiomas in children is very promising because it opens new possibilities of "conservative surgery", reducing the terms of treatment, improving the cosmetic results, besides, there are no difficult anatomical localizations for the method. The choice of optimal radiation parameters allows the unique properties of laser energy to be exhibited effectively in extradermal pediatric surgery. PMID:2124307

Sleptsov, V P; Diadiura, A M

1990-08-01

189

Management of periorbital hemangioma by intralesional glucocorticoids and systemic propranolol: a single-center retrospective study  

PubMed Central

Periorbital hemangioma may lead to the vision impairment so effective treatment should be adopted in time. In this study, we made a retrospective analysis of intralesional glucocorticoids and systemic propranolol in the management of periorbital hemangioma. From Jan. 2006 to Dec. 2013, twenty-five children with periorbital hemangioma were enrolled into this study. Among them, sixteen children accepted intralesional injection of compound betamethasone preparation. Eight children accepted systemic propranolol. One child accepted both of the two treatments. The follow-up period ranged from 6 months to 60 months. The results showed that in the patients with intralesional compound betamethasone preparation, 13/16 patients’ tumors involuted completely. 3/16 patients’ tumors didn’t involute completely at the end of follow-up. In the patients with systemic propranolol, 8/8 patients’ tumors involuted almost completely. One patient didn’t respond to intralesional glucocorticoids, and so switched to systemic propranolol, which lead to the involution of tumor finally. The adverse effects in the patients with intralesional glucocorticoids included local soft tissue atrophy, local ulcer, and Cushing-like manifestations, which occurred in three patients respectively. In the patients with systemic propranolol, mild diarrhoea occurred in one child. According to our observation, both of intralesional glucocorticoids and systemic propranolol achieved good results in the management of periorbital hemangioma. Systemic propranolol showed superiority in efficacy and safety. We recommend systemic propranolol as the first-line therapy. However, for the children who can’t tolerate systemic propranolol, intralesional glucocorticoids still is a feasible choice. PMID:24955168

Yuan, Si-Ming; Cui, Lei; Guo, Yao; Xue, Chun-Yan; Hong, Zhi-Jian; Jiang, Hui-Qing

2014-01-01

190

Changes in Matrix Composition during the Growth and Regression of Human Hemangiomas  

Microsoft Academic Search

Background.Hemangiomas offer an uncommon opportunity to study rapid vessel growth and spontaneous regression of a vascular human tumor. In contrast, venous malformations are another type of vascular tumor that grows slowly without spontaneous involution. Extracellular matrix (ECM) molecules modulate the responsiveness of endothelial cells to mitogenic stimuli such as basic fibroblast growth factor (bFGF), a well-recognized stimulant of angiogenesis. In

Young-Chul Jang; Subbu Arumugam; Marina Ferguson; Nicole S. Gibran; F. Frank Isik

1998-01-01

191

[Hepatic encephalopathy].  

PubMed

Hepatic encephalopathy (EH) is a severe complication of hepatic cirrhosis that is characterized by multiple neuropsychiatric manifestations. EH is usually triggered by a precipitating factor and occurs in patients with severely impaired hepatic function. Minimal EH is characterized by minor cognitive impairments that are difficult to specify but represent a risk for the patients. The primary pathophysiological mechanism of EH is considered to be an increase in blood ammonia with an impairment in the patency of the blood-brainbarrier and its metabolism to glutamine in astrocytes. The diagnosis is clinical and neuroimaging techniques can be complementary. The diagnosis of minimal EH requires specific neurocognitive tests. The clinical evaluation should be directed towards identifying the trigger. Nonabsorbable disaccharides and rifaximin constitute the treatment of choice, along with prophylaxis for new episodes. PMID:25087716

Córdoba, Juan; Mur, Rafael Esteban

2014-07-01

192

Central Retinal and Posterior Ciliary Artery Occlusion After Intralesional Injection of Sclerosant to Glabellar Subcutaneous Hemangioma  

SciTech Connect

The aim of this study is to describe vision loss caused by central retinal artery and posterior ciliary artery occlusion as a consequence of sclerotherapy with a polidocanol injection to a glabellar hemangioma. An 18-year-old man underwent direct injection with a 23-gauge needle of 1 mL of a polidocanol-carbon dioxide emulsion into the glabellar subcutaneous hemangioma under ultrasound visualization of the needle tip by radiologists. He developed lid swelling the next day, and 3 days later at referral, the visual acuity in the left eye was no light perception. Funduscopy revealed central retinal artery occlusion and fluorescein angiography disclosed no perfusion at all in the left fundus, indicating concurrent posterior ciliary artery occlusion. The patient also showed mydriasis, blepharoptosis, and total external ophthalmoplegia on the left side. Magnetic resonance imaging demonstrated the swollen medial rectus muscle. In a month, blepharoptosis and ophthalmoplegia resolved but the visual acuity remained no light perception. Sclerosing therapy for facial hemangioma may develop a severe complication such as permanent visual loss.

Matsuo, Toshihiko, E-mail: matsuot@cc.okayama-u.ac.j [Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Department of Ophthalmology (Japan); Fujiwara, Hiroyasu; Gobara, Hideo; Mimura, Hidefumi; Kanazawa, Susumu [Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Department of Radiology (Japan)

2009-03-15

193

Propranolol enhanced adipogenesis instead of induction of apoptosis of hemangiomas stem cells  

PubMed Central

Propranolol has been widely used in treating infantile hemangiomas (IHs). But recurrence of IHs was found in some cases on cessation of propranolol treatment. The other is that Chinese individuals reacted to propranolol differently from American Whites. Whether the difference of sensitivity is due to the ? adrenoceptor (?-AR) expression pattern of hemangioma initiating cells remains unclear. In the present study, we isolated hemangioma-derived stem cells (hemSCs) from proliferative IHs and analyzed the biological characteristics and ?-AR expression pattern of hemSCs by immunostaining, Western blotting and multilineage differentiation assay as well. We also tested the effects of propranolol on hemSCs by evaluating VEGF expression, proliferation and apoptosis related parameters. Our results indicated that CD133+ hemSCs located pre-vascular in proiferative IH tissues. Both ?1 and ?2-AR were expressed, while ?2-AR was dominant on hemSCs. Propranolol at 100-150 ?M inhibited proliferation of hemSCs, not did 50 ?M. Propranolol down-regulated VEGF expression of hemSCs, instead of inducing apoptosis. The adipogenic potential was enhanced by propranolol. Therefore, our current results suggested propranolol could not induce apoptosis of hemSCs, but played a curative role though suppressing VEGF synthesis and enhancement of adipogenesis of hemSCs. Our results might partially provide the insight of mechanism of relapse in some cases on cessation of propranolol treatment. PMID:25120757

Ma, Xiaorong; Zhao, Tinghui; Ouyang, Tianxiang; Xin, Shujia; Ma, Yueting; Chang, Mengling

2014-01-01

194

Superior Mesenteric Artery Syndrome due to a Vertebral Hemangioma and Postpartum Osteoporosis following Treatment  

PubMed Central

In pregnancy, advanced vertebral hemangiomas may be seen, and these require treatment. The case reported here is of a 35-year-old female in the 32nd week of pregnancy who was admitted to the orthopaedics clinic with a history of backache and difficulty walking. A burst fracture of L1 associated with a vertebral hemangioma was identified with an L3 compression fracture secondary to osteoporosis. The local kyphosis angle between T12 and L2 was 27°. Kyphotic deformity was corrected and postoperatively, the measured T12–L2 local kyphotic angle was 9°. Twelve hours postoperatively, oral nutrition was allowed, but she developed nausea and vomiting and twenty-four hours postoperatively, an electrolyte imbalance developed. Postoperatively, the patient was diagnosed with superior mesenteric artery syndrome. To the best of our knowledge, this is the first reported case of superior mesenteric artery syndrome, which occurred following the correction of a kyphotic deformity that had developed secondary to an advanced hemangioma in pregnancy. PMID:25685576

Elmadag, Mehmet; Güzel, Yunus; Uzer, Gokcer; Tuncay, ?brahim

2015-01-01

195

Successful treatment of oral itraconazole for infantile hemangiomas: A case series.  

PubMed

Infantile hemangiomas can present a therapeutic challenge to clinicians, especially when associated with severe pain and feeding difficulties. The standard therapeutic management includes corticosteroids and propranolol. However, the clinical response is not always satisfactory. We present six cases of infantile hemangiomas successfully treated with oral itraconazole approximately 5 mg/kg per day. In the first month, the red color of the lesions became a little lighter and the growth of the lesions was controlled in all cases. An obvious clinical improvement was noted in all cases during the 3-month period, with 80-100% improvement in each patient at the end of the treatment, which was judged by both their parents and the dermatologists. Compliance with treatment instructions of oral itraconazole in infants was judged to be very good. Side-effects were mild and limited. Although itraconazole can inhibit angiogenesis and tumor growth in vitro and in vivo associated with some cancers, further research is required to understand the pathogenesis of infantile hemangiomas and the mechanism of itraconazole. PMID:25512128

Ran, Yuping; Chen, Shuang; Dai, Yalin; Kang, Daoxian; Lama, Jebina; Ran, Xin; Zhuang, Kaiwen

2015-02-01

196

Effects of propranolol and isoproterenol on infantile hemangioma endothelial cells in vitro  

PubMed Central

The aim of the present study was to investigate the effects of propranolol and isoproterenol on the growth curve of infantile hemangioma endothelial cells (IHECs) in vitro and determine the functions of the ?-adrenergic receptor in the pathogenesis of infantile hemangioma. IHECs were divided into three groups: The control group, the propranolol group (PG) and the isoproterenol group (IG). The PG and IG were administered with high, medium and low concentrations of the corresponding drugs. The cell growth in each group was determined using the MTT assay. A high propranolol concentration resulted in the inhibition of cell growth. By comparison, isoproterenol promoted cell growth. Within a specific time-frame (72–96 h), high drug concentrations (20 ?g/ml) elicited strong effects on the cells. At certain concentrations, propranolol inhibited cell growth once the proliferation stage of IHECs had been affected for a specific length of time, whereas isoproterenol yielded opposite results. The ?-adrenergic receptor elicits an important effect in the pathogenesis of infantile hemangioma. PMID:25009634

ZHU, YALIN; TUERXUN, AERZIGULI; HUI, YAN; ABLIZ, PARIDE

2014-01-01

197

Drug-induced hepatitis  

MedlinePLUS

Toxic hepatitis ... to get liver damage. Some drugs can cause hepatitis with small doses, even if the liver breakdown ... liver. Many different drugs can cause drug-induced hepatitis. Painkillers and fever reducers that contain acetaminophen are ...

198

Use of flashlamp-pumped pulsed dye laser in the treatment of superficial vascular malformations and ulcerated hemangiomas.  

PubMed

A retrospective study of 502 patients treated with tunable flashlamp pulsed dye laser for superficial vascular malformations (433), ulcerated hemangiomas (65) and postinvolutional redness (4) is presented. Patients were treated in the period from June 1997 to March 2006, with follow-up ranging from six months to four years. The age of the patients ranged from three months to 80 years. Correlation between clinical response and patients' age, location of lesion and number of treatments were evaluated in groups of superficial vascular malformations, whereas healing rates of the ulceration were assessed in a series of hemangiomas. The result were judged to be excellent in 51%, good in 39%, fair in 7% and poor in 3% of patients with vascular malformations. Excellent ultimate outcome confirmed the clinical efficacy of the use of the pulsed dye laser in the treatment of dermal vascular malformations, which also appears to have good prospects in the management of hemangioma complication. PMID:21282744

Di Maio, Luigi; Baldi, Alfonso; Dimaio, Valerio; Barzi, Alberto

2011-01-01

199

Successful propranolol treatment of a large size infantile hemangioma of the face causing recurrent bleeding and visual field disruption.  

PubMed

A 29 days old Pakistani female infant was presented to our outpatient department with two weeks history of a rapidly progressing large size facial hemangioma involving most of the right cheek and right eyelids. The infant was unable to open the right eye. There was also a small hemangioma on the right second toe. Additionally, three similar lesions were found on the right side of the palate and adjoining buccogingival surfaces. The parents were particularly concerned about the explosive progression of the lesions, recurrent bleeding episodes from ulcerated areas of the cheek lesion and complete occlusion of the right eye. Following four weeks therapy with propranolol in a dose of 2 mg/kg/day, the hemangiomas rapidly regressed, the bleeding episodes ceased and the infant started opening the eye. PMID:25606481

Saaiq, Muhammad; Ashraf, Bushra; Siddiqui, Saad; Ahmad, Shehzad; Salman Zaib, Muhammad

2015-01-01

200

Successful Propranolol Treatment of a Large Size Infantile Hemangioma of the Face Causing Recurrent Bleeding and Visual Field Disruption  

PubMed Central

A 29 days old Pakistani female infant was presented to our outpatient department with two weeks history of a rapidly progressing large size facial hemangioma involving most of the right cheek and right eyelids. The infant was unable to open the right eye. There was also a small hemangioma on the right second toe. Additionally, three similar lesions were found on the right side of the palate and adjoining buccogingival surfaces. The parents were particularly concerned about the explosive progression of the lesions, recurrent bleeding episodes from ulcerated areas of the cheek lesion and complete occlusion of the right eye. Following four weeks therapy with propranolol in a dose of 2 mg/kg/day, the hemangiomas rapidly regressed, the bleeding episodes ceased and the infant started opening the eye. PMID:25606481

Saaiq, Muhammad; Ashraf, Bushra; Siddiqui, Saad; Ahmad, Shehzad; Salman Zaib, Muhammad

2015-01-01

201

Treatment of lip hemangioma using forced dehydration with induced photocoagulation via diode laser: report of three cases.  

PubMed

Several vascular lesions are related to the lip area. There is no universally accepted protocol for the treatment of hemangiomas and vascular malformations. In the oral cavity, high-power lasers represent an excellent therapeutic option for this type of lesion. Their coagulative properties allow for the performance of procedures without the risk of bleeding, which promotes a better healing pattern and a differentiated postoperative appearance. This study describes three cases of lip hemangioma treated with forced dehydration with induced photocoagulation (FDIP) via diode laser. All the reported cases were followed up until complete healing of the operated area had total remission of lesions, with no complications or adverse effects. The findings of the present study suggest that FDIP is effective and useful in the treatment of hemangiomas in the oral cavity. Laser treatment of these lesions prevents their recurrence and is well tolerated by patients. PMID:25577591

Jasper, Juliana; Camilotti, Renata Stifelman; Pagnoncelli, Rogério Miranda; Poli, Vladimir Dourado; da Silveira Gerzson, Alexandre; Gavin Zakszeski, Ana Maria

2015-03-01

202

Late results after resection of benign hepatic tumors: clinical and radiological findings.  

PubMed

The purpose of our work was to provide data on the recurrence of resected benign hepatic lesions and to evaluate the value of follow-up examinations in this group of patients. From August to October 1993, 75 patients who had been admitted for liver surgery for benign tumors between 1975 and 1993 were controlled by physical examinations, serological tests, US, and, in the case of equivocal US findings, by CT. The histological diagnoses of the operative specimen included hydatidosis in 43 patients, focal nodular hyperplasia (FNH) in 12 patients, liver cell adenoma in 8 patients, cavernous hemangioma in 8 patients, and congenital cyst in 4 patients. Hepatic scars were observed in 36 of the 75 patients. Four cases of intrahepatic recurrence and 1 case of intraperitoneal spread were observed in the 42 patients with recent hydatosis. Long-term postoperative controls (specific serological tests, US) are necessary in the management of patients with hydatid disease. Follow-up examinations are not indicated in asymptomatic patients who have been operated on for FNH, hemangioma, or congenital cysts. PMID:9087351

Krug, B; Zieren, H U; Jung, G; Hemme, A; Heindel, W; Krings, F

1997-01-01

203

Giant magnetoresistance: a primer  

Microsoft Academic Search

An introduction to the phenomenon of giant magnetoresistance is presented. It is pointed out that the giant magnetoresistance effect appears in a number of ultrathin multilayer systems in which thin magnetic films, a few tens of Å thick, are separated by nonmagnetic metal films, also on the order of tens of Å thick. For the effect to appear, the primary

R. L. White

1992-01-01

204

Giant Sequoia Pinecone  

USGS Multimedia Gallery

A pinecone of a giant sequoia rests on the forest floor. A large sequoia tree can have several thousand pinecones at a time. Although giant sequoia trees are among the largest trees in the world, their pinecones are comparatively small, usually only 2 inches or so....

205

Giant Sequoia Pinecone  

USGS Multimedia Gallery

A single giant sequoia pinecone rests in the bark of its parent. A large sequoia tree can have several thousand pinecones at a time. Although giant sequoia trees are among the largest trees in the world, their pinecones are comparatively small, usually only 2 inches or so....

206

A Case of Intranasal Hemangioma and Concurrent Tetracycline-induced Ulcerative Gastritis in Dogs  

PubMed Central

Incidence of drug-induced gastritis and ulceration in human medicine is well established. Besides, unilateral hemangioma, a unique concurrent case of tetracycline induced gastric toxicity in a dog, characterized by gastritis and ulceration is being reported here. Grossly, the appearance of gastric ulcers mimicked the appearance of Italian pizza. Histological examination further supported drug-induced etiology in this case. This is probably the one of the few cases in the annals of veterinary medicine to be documented as drug-induced gastric toxicity in dog. PMID:21042472

Banga, H. S.; Deshmukh, S.; Brar, R. S.; Gadhave, P. D.; Chavhan, S. G.; Sandhu, H. S.

2010-01-01

207

Multiple cutaneous hemangiomas in a patient with combined pituitary hormone deficiency.  

PubMed

Combined pituitary hormone deficiency (CPHD) refers to a rare heterogeneous group of conditions in which there is a deficiency in at least two anterior pituitary hormones. Patients with POU1F1 mutations show a combined pituitary deficiency with low or absent levels of growth hormone, prolactin, and thyroid-stimulating hormone. In this study, a 7-month-old girl with a CPHD is presented. She had facial dysmorphologic features, hypertrichosis, and hypotonia. Additionally, she also presented with multiple cutaneous hemangioma that until now has not been reported in association with this disorder. PMID:24025721

Aykut, Ayca; Ozen, Samim; S?msek, Damla Gok?en; Onay, Huseyin; Cogulu, Ozgur; Darcan, Sukran; Ozkinay, Ferda

2014-01-01

208

Dramatic Shift in the Infantile Hemangioma Treatment Paradigm at a Single Institution  

PubMed Central

Historically, the first line of treatment for infantile hemangioma (IHs) has been oral corticosteroids, but because of recent discoveries recognizing the effectiveness of oral and topical beta-blockers, IH management is dynamically changing. With these new treatment options, some physicians are altering the way they manage IHs despite having little evidence based data on the treatment methods. Highlighting treatment changes at a single large tertiary pediatric referral center, we conclude that despite the numerous studies already published on this topic, more reliable prospective studies are needed to determine the safety, efficacy, and best treatment algorithms for the use of topical and oral beta-blockers for the treatment of IHs. PMID:24117504

Gomulka, Jennifer; Siegel, Dawn H.

2014-01-01

209

Viral hepatitis.  

PubMed

Hepatitis A is still the most frequently reported vaccine preventable disease. A reduction in the incidence will only be achieved by routine childhood vaccination rather than by targeted vaccination of high-risk groups. A larger vaccine program is warranted. Hepatitis B remains a large public health problem. Vaccination targeted to high-risk adults failed to decrease the incidence of hepatitis B virus (HBV) infection. Sexual as well as nosocomial transmission remain serious problems. Vaccine escape variants have also been identified in newborns from infected mothers who had been vaccinated at birth. Clearance of HBV infection results from complex immune mechanisms including TH1 cytokines significantly associated with HLA class II alleles. Escape HBV mutants, especially precore mutants, influence the outcome. The sequences of the promoter and other critical regions were associated with severe activity. Lamivudine is a major advance in therapy of chronic hepatitis B which was recently approved in many countries. Although drug resistant mutants may be selected during therapy, additional nucleoside analogues including adefovir are promising. Optimal combination strategies of different active compounds need to be researched. Three per cent of the world population has been infected with hepatitis C virus (HCV). Epidemiology has shifted from transfusion to non-transfusion settings. Intravenous drug abuse is currently the main risk but nosocomial infection is also of concern. Three independent factors seem associated with fibrosis progression: age, daily alcohol consumption of 50 g or more and male gender. Median duration of progression to cirrhosis is about 30 years. At the cirrhotic stage, about 3-5% of patients per year develop hepatocellular carcinoma. There is little evidence that direct cytopathicity plays a significant role in liver cell injury. HCV also infects extrahepatic cells which seems critical in the pathogenesis of the many extrahepatic manifestations. The recent identification of CD81 protein as one of the HCV receptor candidates may help us to understand how chronic HCV infection may trigger a wide spectrum of clinical manifestations, autoimmune or even lymphoproliferative, through potent continuous B cell activation in the context of various host and/or environmental cofactors. Direct measurement of HCV RNA has clarified HCV replication kinetics and variability. Among patients with chronic hepatitis C, 48 weeks of treatment with interferon/ribavirin therapy produced a response rate of 28% among those with genotype 1 and 66% with other genotypes. Similar differences were found for combination therapy among patients who had relapsed following previous interferon (IFN) therapy. Viral load prior to treatment has been clearly shown to be predictive of response to interferon treatment, with increased viral load associated with decrease rates of response. In patients non-responsive to interferon, a second course of interferon alone has no beneficial effect whereas combination therapy may induce response in 25%. In conclusion, combination therapy should be given in all situations. Viral eradication should not be the only objective of the treatment since histological improvement may be obtained despite persisting viral replication with prolonged maintenance of antiviral therapy. PMID:17035815

Trépo, C; Zoulim, F; Pradat, P

1999-10-01

210

Hepatic encephalopathy.  

PubMed

Hepatic encephalopathy (HE) represents a continuum of transient and reversible neurologic and psychiatric dysfunction. It is a reversible state of impaired cognitive function or altered consciousness in patients with liver disease or portosystemic shunting. Over the last several years, high-quality studies have been conducted on various pharmacologic therapies for HE; as more data emerge, it is hoped that HE will become a more easily treated complication of decompensated liver disease. In the interim, it is important that physicians continue to screen for minimal HE and treat patients early in addition to continuing to provide current treatments of overt HE. PMID:22541700

Khungar, Vandana; Poordad, Fred

2012-05-01

211

Hepatic hydrothorax.  

PubMed

Hepatic hydrothorax (HH) is an uncommon complication in patients with end-stage liver disease. Only 5% to 10% of patients with end-stage liver disease develop HH, which may result in dyspnea, hypoxia, and infection, and portends a poor prognosis. The most likely explanation for development is passage of fluid from the peritoneal space to the pleural space due to small diaphragmatic defects. Initial management consists of diuretics with dietary sodium restriction and thoracentesis, and a transjugular intrahepatic portosystemic shunt may ultimately be required. Afflicted patients can develop morbid and fatal complications, pose management dilemmas, and should warrant evaluation for liver transplantation. PMID:24679505

Norvell, John Paul; Spivey, James R

2014-05-01

212

Down-Regulation of mir-424 Contributes to the Abnormal Angiogenesis via MEK1 and Cyclin E1 in Senile Hemangioma: Its Implications to Therapy  

PubMed Central

Background Senile hemangioma, so-called cherry angioma, is known as the most common vascular anomalies specifically seen in the aged skin. The pathogenesis of its abnormal angiogenesis is still unclear. Methodology/Principal Findings In this study, we found that senile hemangioma consisted of clusters of proliferated small vascular channels in upper dermis, indicating that this tumor is categorized as a vascular tumor. We then investigated the mechanism of endothelial proliferation in senile hemangioma, focusing on microRNA (miRNA). miRNA PCR array analysis revealed the mir-424 level in senile hemangioma was lower than in other vascular anomalies. Protein expression of MEK1 and cyclin E1, the predicted target genes of mir-424, was increased in senile hemangioma compared to normal skin or other anomalies, but their mRNA levels were not. The inhibition of mir-424 in normal human dermal microvascular ECs (HDMECs) using specific inhibitor in vitro resulted in the increase of protein expression of MEK1 or cyclin E1, while mRNA levels were not affected by the inhibitor. Specific inhibitor of mir-424 also induced the cell proliferation of HDMECs significantly, while the cell number was decreased by the transfection of siRNA for MEK1 or cyclin E1. Conclusions/Significance Taken together, decreased mir-424 expression and increased levels of MEK1 or cyclin E1 in senile hemangioma may cause abnormal cell proliferation in the tumor. Senile hemangioma may be the good model for cutaneous angiogenesis. Investigation of senile hemangioma and the regulatory mechanisms of angiogenesis by miRNA in the aged skin may lead to new treatments using miRNA by the transfection into senile hemangioma. PMID:21179471

Nakashima, Taiji; Jinnin, Masatoshi; Etoh, Tomomi; Fukushima, Satoshi; Masuguchi, Shinichi; Maruo, Keishi; Inoue, Yuji; Ishihara, Tsuyoshi; Ihn, Hironobu

2010-01-01

213

Hepatitis B therapy  

Microsoft Academic Search

The goal of hepatitis B treatment is to prevent cirrhosis, liver decompensation and hepatocellular carcinoma. In clinical practice, treatment response is determined by suppression of serum HBV DNA levels, hepatitis B e antigen seroconversion to hepatitis B e antibody, hepatitis B surface antigen loss, normalization of alanine aminotransferase levels and improvement in liver histology. Patients with life-threatening liver disease, and

Hellan Kwon; Anna S. Lok

2011-01-01

214

Thoracic endovascular aortic repair and coil embolization of the pulmonary artery for primary racemose hemangioma of the bronchial artery with a bronchial-pulmonary artery fistula.  

PubMed

A 69-year-old male visited a doctor with dyspnea. A bronchial-pulmonary artery fistula, which is called racemose hemangioma, and dilated pulmonary artery were detected by a computed tomography (CT) scan. The bronchial-pulmonary artery fistula can cause lethal hemoptysis, therefore, we performed thoracic endovascular aortic repair (TEVAR) to seal the bronchial artery and coil embolization of the pulmonary artery. Postoperative CT showed the thrombosed racemose hemangioma of the bronchial artery. TEVAR and coil embolization of the pulmonary artery is considered to be a useful treatment option for a racemose hemangioma. PMID:25245045

Matsubara, Yutaka; Morisaki, Koichi; Matsuda, Daisuke; Aoyagi, Yukihiko; Tanaka, Shinichi; Okadome, Jun; Fukunaga, Ryota; Matsumoto, Takuya; Maehara, Yoshihiko

2014-09-22

215

Hepatic osteodystrophy  

PubMed Central

Summary Metabolic disturbances of bone are frequent in patients with chronic liver disease. The prevalence of osteoporosis among patients with advanced chronic liver disease is reported between 12% and 55%; it is higher in primary biliary cirrhosis. All patients with advanced liver disease should be screened for osteoporosis with a densitometry, especially if the etiology is cholestatic and in the presence of other risk factors. Clinical relevance of hepatic osteodystrophy increases after liver transplantation. After liver transplant, a rapid loss of bone mineral density can be detected in the first 6 months, followed by stabilization and slight improvement of the values. At the time of transplantation, bone density values are very important prognostic factors. Therapy of hepatic osteodystrophy is based primarily on the control of risk factors: cessation of tobacco and alcohol assumption, reduction of caffeine ingestion, exercise, supplementation of calcium and vitamin D, limitation of drugs such as loop diuretics, corticosteroids, cholestyramine. Bisphosphonates have been proposed for the therapy of osteoporosis in patients with liver disease, particularly after liver transplantation. The possible side effects of oral administration of bisphosphonates, such as the occurrence of esophageal ulcerations, are of particular concern in patients with liver cirrhosis and portal hypertension, due to the risk of gastrointestinal hemorrhage from ruptured esophageal varices, although this risk is probably overestimated. PMID:25568651

Gatta, Angelo; Verardo, Alberto; Di Pascoli, Marco; Giannini, Sandro; Bolognesi, Massimo

2014-01-01

216

Alcoholic hepatitis  

PubMed Central

Alcoholic hepatitis (AH) is a clinical syndrome characterized by jaundice and liver failure that generally occurs after decades of harmful alcohol consumption. Less severe forms of acute AH (AAH) frequently respond to alcoholic abstinence; whereas severe AAHs are characterized by a poor prognosis: up to 40-60% of these patients die within six months. Glucocorticoids currently remain the mainstay for treating severe AAH in patients with Maddrey’s Discriminant Function score > 32. Standard contraindications include recent upper gastrointestinal bleeding, renal insufficiency and uncontrolled infections. The evaluation of concomitant viral infections (hepatitis C and B viruses) is mandatory. Liver transplantation (LT), in non-responders patients, is a possible therapeutic option for severe AAH, but it is rarely used because a 6-month abstinence period is required before listing for LT. Unfortunately, most of these patients die before the end of this sober period. In our opinion, in case of severe AAH and in case of patients with a good social support and without severe psychotic or personality disorders, the lack of pre-LT abstinence period alone should not be considered a hindrance to LT. PMID:23904876

Testino, G

2013-01-01

217

Alcoholic hepatitis.  

PubMed

Alcoholic hepatitis (AH) is a clinical syndrome characterized by jaundice and liver failure that generally occurs after decades of harmful alcohol consumption. Less severe forms of acute AH (AAH) frequently respond to alcoholic abstinence; whereas severe AAHs are characterized by a poor prognosis: up to 40-60% of these patients die within six months. Glucocorticoids currently remain the mainstay for treating severe AAH in patients with Maddrey's Discriminant Function score > 32. Standard contraindications include recent upper gastrointestinal bleeding, renal insufficiency and uncontrolled infections. The evaluation of concomitant viral infections (hepatitis C and B viruses) is mandatory. Liver transplantation (LT), in non-responders patients, is a possible therapeutic option for severe AAH, but it is rarely used because a 6-month abstinence period is required before listing for LT. Unfortunately, most of these patients die before the end of this sober period. In our opinion, in case of severe AAH and in case of patients with a good social support and without severe psychotic or personality disorders, the lack of pre-LT abstinence period alone should not be considered a hindrance to LT. PMID:23904876

Testino, G

2013-06-15

218

Unstable giant gravitons  

SciTech Connect

We find giant graviton solutions in Frolov's three parameter generalization of the Lunin-Maldacena background. The background we study has {gamma}-tilde{sub 1}=0 and {gamma}-tilde{sub 2}={gamma}-tilde{sub 3}={gamma}-tilde. This class of backgrounds provides a nonsupersymmetric example of the gauge theory/gravity correspondence that can be tested quantitatively, as recently shown by Frolov, Roiban, and Tseytlin. The giant graviton solutions we find have a greater energy than the point gravitons, making them unstable states. Despite this, we find striking quantitative agreement between the gauge theory and gravity descriptions of open strings attached to the giant.

Mello Koch, Robert de [Department of Physics and Centre for Theoretical Physics, University of the Witwatersrand, Wits, 2050 (South Africa); Stellenbosch Institute for Advanced Studies, Stellenbosch (South Africa); Ives, Norman; Smolic, Jelena; Smolic, Milena [Department of Physics and Centre for Theoretical Physics, University of the Witwatersrand, Wits, 2050 (South Africa)

2006-03-15

219

Imaging Spectrum of Hemangioma and Vascular Malformations of the Head and Neck in Children and Adolescents  

PubMed Central

Vascular lesions of the head and neck region in children constitute an interesting group of lesions that benefit immensely from imaging techniques. Imaging is essential for identification, characterization, and delineation of the extent of lesion and subsequent follow-up. Infantile hemangiomas, which are vascular tumors with a specific evolution pattern, constitute a large majority of these lesions. On the other hand, there are vascular malformations, which are anomalies of the vascular system, consisting of a range of vascular tissues associated with various flow patterns. When diagnosis is clinically evident, imaging should utilize non-radiation techniques and address the issues necessary for management. Timing and interpretation of imaging methods employed in assessing childhood vascular lesion should also take into consideration the natural history so that imaging is performed to address a specific question. This review highlights the typical appearance of a hemangioma and a group of vascular malformations of the head and neck. For descriptive purpose, an attempt has been made to group lesions into specific subsites, with each one having specific clinical significance. Cases included illustrate the spectrum of the disease ranging from classical form in young children to slightly differing manifestations of the disease in adolescents and adults. The illustrations also provide a novel way of presenting image data using volume-rendering techniques of 3D data. Multi-modality team interaction and management strategies of these complex lesions are also emphasized. PMID:25161800

Bhat, Venkatraman; Salins, Paul C; Bhat, Varun

2014-01-01

220

Intradural Extramedullary Capillary Hemangioma in the Upper Thoracic Spine: A Review of the Literature  

PubMed Central

Capillary hemangiomas are benign tumors found in the skin and soft tissues in younger people. They occur in the central nervous system only rarely, and intradural occurrence is extremely rare. We report here a 60-year-old man presenting with thoracic girdle pain and progressive gait disturbance. Magnetic resonance images of the thoracic spine showed a 12 × 8 × 20?mm, well-defined intradural mass at the T2 level, compressing the spinal cord laterally. Relative to the spinal cord, the mass was hypo- to isointense on T1-weighted images and relatively hyperintense on T2-weighted images, with strong enhancement on contrast-enhanced T1-weighted images. The patient underwent T1-2 hemilaminectomy with resection of the intradural extramedullary tumor, which showed characteristics of a capillary hemangioma on histologic examination. The patient's symptoms improved following the surgery and no clinical or radiological evidence of recurrence was noted at the 2-year follow-up. We present this case with a review of the literature, highlighting features for differential diagnosis. PMID:25045565

Sakai, Toshinori; Higashino, Kosaku; Goda, Yuichiro; Tezuka, Fumitake; Sairyo, Koichi

2014-01-01

221

Intradural extramedullary capillary hemangioma in the upper thoracic spine: a review of the literature.  

PubMed

Capillary hemangiomas are benign tumors found in the skin and soft tissues in younger people. They occur in the central nervous system only rarely, and intradural occurrence is extremely rare. We report here a 60-year-old man presenting with thoracic girdle pain and progressive gait disturbance. Magnetic resonance images of the thoracic spine showed a 12 × 8 × 20?mm, well-defined intradural mass at the T2 level, compressing the spinal cord laterally. Relative to the spinal cord, the mass was hypo- to isointense on T1-weighted images and relatively hyperintense on T2-weighted images, with strong enhancement on contrast-enhanced T1-weighted images. The patient underwent T1-2 hemilaminectomy with resection of the intradural extramedullary tumor, which showed characteristics of a capillary hemangioma on histologic examination. The patient's symptoms improved following the surgery and no clinical or radiological evidence of recurrence was noted at the 2-year follow-up. We present this case with a review of the literature, highlighting features for differential diagnosis. PMID:25045565

Takata, Yoichiro; Sakai, Toshinori; Higashino, Kosaku; Goda, Yuichiro; Tezuka, Fumitake; Sairyo, Koichi

2014-01-01

222

Mixed germ cell tumor of mediastinum/lung masquerading as hemangioma in fine needle biopsy.  

PubMed

The histological predominance of one component in a germ cell tumor can lead to a mistaken diagnosis. Here, we describe a mediastinal teratoma with predominant vascular proliferation (>90%) which on fine needle biopsy was diagnosed as a pulmonary hemangioma. Later, resection specimen revealed other components constituting ~4%, changing the diagnosis while illustrating theimportance of careful evaluation. A 37-year-old Caucasian male with shortness of breath, weight loss, and history of recently resolved pneumonia was diagnosed with hemangioma, after a computed tomography guided fine needle biopsy of a -16.3-cm mediastinal pulmonary mass revealed abundant benign vascular elements. Following tumor excision, ~94% of the sample exhibited predominant vascular elementsThe mass also exhibited rare focal areas of malignant epithelium in a reticular arrangement and undifferentiated pleomorphic cells associated with vascular invasion. These atypical epithelial cells were positive for CD30, pan CK, AFP, ?-HCG and CD 117, thusprocuring a diagnosis of mediastinal mixed germ cell tumor. Although mixed germ cell tumors consist of various tissue types, diagnosis can be easily overlooked if one component dominates. Therefore, obtaining adequate representative neoplasm samples, and sectioning the samples thoroughly, searching for coexisting tissue types is critical for accurate diagnosis. PMID:24056656

Nuti, Rathna; Bodhireddy, Surender; Thirumala, Seshadri

2013-01-01

223

Extra-osseous Ewing's sarcoma of sciatic nerve masquerading as an infected hemangioma: A rare case report  

PubMed Central

Extra-osseous Ewing's Sarcoma (EES) arising from the peripheral nerve is rarely reported in children. Here, we report an instance of EES arising from the left sciatic nerve mimicking an infected hemangioma. This case highlights the need for a high index of suspicion and early histological diagnosis to avoid diagnostic delay. PMID:25336807

Dhua, Anjan K; Bharathi, Ravindhra; Kiran, Chokka Mahesh; Lingam, Pappu Paramartha; Joshi, Manoj

2014-01-01

224

Vascular endothelial growth factor expression and pathological changes in the local tissue of facial hemangiomas following injections with pure alcohol  

PubMed Central

The aim of the present study was to investigate the association between the formation of hemangioma and the expression of vascular endothelial growth factor (VEGF) following local injections of pure alcohol in patients exhibiting hemangioma. Ten healthy subjects (control group) and 10 hemangioma patients (treatment group) were included in the study population, with the hemangioma patients receiving one injection of pure alcohol. The VEGF levels were evaluated in the treatment and control group subjects prior to and following the injection using enzyme-linked immunosorbent assay; furthermore, local tissue was excised to perform pathological analysis one week after the injections. The VEGF levels of the healthy group were identified to be significantly lower when compared with those of the treatment group prior to the injections (P<0.01) and one week after the injections (P<0.01), however, were not significantly different when compared with the treatment group one month after the injections (P>0.01). Therefore, serum VEGF concentrations in the peripheral blood may be a clinical indicator of the efficacy of clinical treatment and aid with determination of the prognosis.

FU, ZHAO-JUN; LI, CHUN-MING; WANG, TAI-HE; JIANG, ZHU-LING; FU, ZHAO-CHEN

2015-01-01

225

Prevalence of Hepatitis E Virus Antibodies in Patients with Chronic Hepatitis B and Chronic Hepatitis C  

Microsoft Academic Search

Objectives: To investigate the prevalence of hepatitis E virus (HEV) among patients with chronic hepatitis B and chronic hepatitis C, serum samples were collected between January and December 2004 from patients with chronic hepatitis B and chronic hepatitis C. Methods: There were 190 adult patients with chronic hepatitis B virus (HBV) and 174 with chronic hepatitis C virus (HCV) infection

A. Bayram; F. Eksi; M. Mehli; E. Sözen

2007-01-01

226

Congenital Hepatic Vascular Malformations  

Microsoft Academic Search

\\u000a Congenital hepatic vascular malformations are rare entities that result in abnormal shunting of blood through the liver. Three\\u000a different types of shunting can occur: arteriovenous (hepatic artery to hepatic vein), arterioportal (hepatic artery to portal\\u000a vein) and portovenous (portal vein to hepatic vein). Malformations result from alterations in the formation of blood vessels\\u000a during fetal development and can occur as

Guadalupe Garcia-Tsao

227

A giant panda  

NSDL National Science Digital Library

The giant panda is endangered because of habitat loss and low birth rates in the wild and captivity. In the past, poaching also lowered the numbers of surviving pandas and they became listed as an endangered species.

Aaron Siirila (None;)

2007-03-16

228

Seismology of Giant Planets  

E-print Network

Seismology applied to giant planets could drastically change our understanding of their deep interiors, as it has happened with the Earth, the Sun, and many main-sequence and evolved stars. The study of giant planets' composition is important for understanding both the mechanisms enabling their formation and the origins of planetary systems, in particular our own. Unfortunately, its determination is complicated by the fact that their interior is thought not to be homogeneous, so that spectroscopic determinations of atmospheric abundances are probably not representative of the planet as a whole. Instead, the determination of their composition and structure must rely on indirect measurements and interior models. Giant planets are mostly fluid and convective, which makes their seismology much closer to that of solar-like stars than that of terrestrial planets. Hence, helioseismology techniques naturally transfer to giant planets. In addition, two alternative methods can be used: photometry of the solar light ref...

Gaulme, Patrick; Schmider, Francois-Xavier; Guillot, Tristan

2014-01-01

229

The Giant Cell.  

ERIC Educational Resources Information Center

Provides directions for the construction of giant plastic cells, including details for building and installing the organelles. Also contains instructions for preparing the ribosomes, nucleolus, nucleus, and mitochondria. (DDR)

Stockdale, Dennis

1998-01-01

230

One-Stage Resection of Giant Invasive Thoracic Schwannoma: Case Report and Review of Literature  

PubMed Central

Background Schwannomas comprise approximately 25% of all spinal tumors, being the third most frequent soft-tissue tumor after hemangiomas and lipomas. Grade 5 invasive giant schwannomas erode the vertebral bodies, involve 2 or more levels, and invade the myofascial planes. Because 3 compartments are involved, these tumors represent a surgical challenge and frequently require staged surgeries with a multidisciplinary surgical team. Case Report We report the case of a 62-year-old female who presented with intermittent upper back pain for 3 years. A magnetic resonance imaging scan of the thoracic spine showed a mass invading the vertebral body, pedicle, and lamina of T4 and part of T3 and T5. Needle biopsy confirmed the diagnosis of schwannoma. The patient underwent surgery using a parascapular extracavitary costotransversectomy approach. Conclusion Giant invasive spinal schwannomas are rare in the thoracic spine, and surgical approaches usually have entailed multiple-stage surgeries with the assistance of other surgical specialties. Our 1-stage complete surgical resection of a giant invasive spinal schwannoma used a parascapular costotransversectomy approach that maintained spinal stability and thus avoided the need for instrumentation. PMID:24688347

Valle-Giler, Edison P.; Garces, Juanita; Smith, Roger D.; Sulaiman, Wale A. R.

2014-01-01

231

A Rare Case of Left Ventricular Intramural Hemangioma Diagnosed Using 1.5-T Cardiac MRI with Histopathological Correlation and Successfully Treated by Surgery  

SciTech Connect

Hemangiomas are vascular tumors composed of blood vessels, frequently localized in the skin and subcutaneous muscles; their localization in the heart is exceptional. The most common localizations are the lateral walls of the left ventricle, the anterior wall, and the septum. Mostly, these tumors grow intracavitarily, rarely intramurally. We describe a singular case of left ventricular intramural hemangioma, detected and diagnosed using newer magnetic resonance imaging (MRI) modalities, confirmed by histopathological results, and treated successfully by surgery.

Marrone, Gianluca, E-mail: gmarrone@ismett.ed [Mediterranean Institute of Transplantation and High Specialization Therapy (ISMETT), Diagnostic and Interventional Radiology (Italy); Sciacca, Sergio, E-mail: ssciacca@ismett.edu; D'Ancona, Giuseppe, E-mail: gdancona@ismett.edu; Pilato, Michele, E-mail: mpilato@ismett.ed [Mediterranean Institute of Transplantation and High Specialization Therapy (ISMETT), Division of Cardiac Surgery (Italy); Luca, Angelo, E-mail: aluca@ismett.ed [Mediterranean Institute of Transplantation and High Specialization Therapy (ISMETT), Diagnostic and Interventional Radiology (Italy); Gridelli, Bruno, E-mail: bgridelli@ismett.ed [Mediterranean Institute of Transplantation and High Specialization Therapy (ISMETT), Division of Surgery (Italy)

2010-02-15

232

Liver transplantation for recurrent hepatic adenoma  

PubMed Central

Hepatic adenoma (HA) is a rare indication for liver transplantation (LTx). So far 20 cases of LTx for HA are reported in PubMed. In rare cases HA presents as multiple hepatic adenomas or recurrent adenoma after initial liver resection and in such cases LTx is the only potential cure and prevents the risk of bleeding or cancer transformation into hepatocellular carcinoma. We report the case of a 56 years old lady who underwent a left hepatectomy for giant adenoma in 2005 and resection of segment V-VI for recurrence of liver adenoma in 2007. She developed a second recurrence of HA with 3 new lesions in the right liver in 2008. The patient underwent LTx. After 3 years the patient is alive with no evidence of disease. LTx is indicated in patients with HA in which resection is not technically feasible. PMID:23556048

Vennarecci, Giovanni; Santoro, Roberto; Antonini, Mario; Ceribelli, Cecilia; Laurenzi, Andrea; Moroni, Enrico; Burocchi, Mirco; Lepiane, Pasquale; Ettorre, Giuseppe Maria

2013-01-01

233

Endoscopic neodymium:yttrium aluminium garnet (Nd:YAG) laser irradiation of a bladder hemangioma associated with Klippel-Weber syndrome.  

PubMed

A case of endoscopic neodymium:yttrium aluminium garnet (Nd:YAG) laser coagulation of a bladder hemangioma associated with Klippel-Weber syndrome is presented. The patient presented with extensive nevus and swelling of the left lower limb since birth. She was diagnosed with Klippel-Weber syndrome by angiography at the age of 1 year. Gross hematuria had been observed since she was 1 year old and, in addition, endoscopic examination revealed diffuse bladder hemangiomas. At 8 years of age, gross hematuria became worse and gait disturbance also appeared. She was referred to the Department of Urology at Tohoku University School of Medicine for endoscopic treatment in June 1998. Under general anesthesia, the bladder was inflated with CO2 gas and the hemangiomas were coagulated by Nd:YAG laser photonic irradiation endoscopically. Gross hematuria was markedly improved immediately following this treatment. Klippel-Weber syndrome is a rather uncommon disease which shows various types of vascular anomaly and hypertrophy of the lower extremities. Three to 6% of the patients have associated bladder hemangiomas. Although Nd:YAG laser irradiation provides results superior to alternative therapy and is the preferred treatment for most patients with bladder hemangioma, in this case, hemangiomas are multiple and present the possibility of re-bleeding, therefore long-term and close follow up is important. PMID:10810971

Kato, M; Chiba, Y; Sakai, K; Orikasa, S

2000-04-01

234

Infantile Hemangioma—Mechanism(s) of Drug Action on a Vascular Tumor  

PubMed Central

Infantile hemangioma (IH), a benign vascular tumor, is the most common tumor of infancy, with an incidence of 5%–10% at the end of the first year. The tumor displays a distinctive life cycle consisting of a proliferating phase, occurring in the first months of life, followed by an involuting phase. Thus, IH represents a unique model of postnatal vasculogenesis, angiogenesis, and vessel regression. Traditionally, corticosteroids were the drug of choice when treatment of IH was indicated. In recent years, beta-blockers, most specifically propranolol, have serendipitously been shown to be an effective pharmacological treatment. This article will focus on the mechanism of action of these two drugs, the old and the new treatments, in slowing the growth and accelerating involution of IH. PMID:22229118

Greenberger, Shoshana; Bischoff, Joyce

2011-01-01

235

Simple and Easy Surgical Technique for Infantile Hemangiomas: Intralesional Excision and Primary Closure  

PubMed Central

Objective: Infantile hemangioma (IH) is a benign vascular tumor that gradually shrinks over several years. Involuting or involuted IHs usually retain their shape, however, and result in redundant skin or conspicuous scarring due to ulceration in the proliferating phase. We present a case series of 12 patients who underwent intralesional excision and primary closure for treatment of involuting or involuted IH. Methods: Twelve patients (5 boys, 7 girls) underwent our treatment method for involuting or involuted IH. A blinded assessor evaluated clinical result of each patient. Results: Surgical results were excellent in 4 patients, good in 6, and fair in 2. A small dog ear was prominent in 1 patient; nevertheless, all parents were satisfied with the results. Conclusions: Intralesional excision and primary closure for treatment of involuting or involuted IH is an easy and simple procedure that does not result in dog-ear formation or elongated residual scarring. PMID:25610518

Osaki, Takeo; Ishinagi, Hiroyoshi; Ejiri, Hirotaka; Terashi, Hiroto

2015-01-01

236

Hepatitis Foundation International  

MedlinePLUS

... OF HFI'S NEWSLETTER READ MORE... Hepatitis Patient Registry Network (HepPRN) ENGAGING INDIVIDUALS. FINDING SOLUTIONS. SAVING LIVES. HFI ... pleased to launch its new Hepatitis Patient Registry Network (HepPRN). The patient-centric registry collects self-reported ...

237

Hepatitis B Test  

MedlinePLUS

... IgM; anti-HBe; Hepatitis B e Antibody; HBV DNA Formal name: Hepatitis B Virus Testing Related tests: ... of tests detect or evaluate the genetic material ( DNA ) of the virus. The pattern of test results ...

238

Travelers' Health: Hepatitis B  

MedlinePLUS

... HBsAg, hepatitis B surface antigen; IM, intramuscular; ELU, ELISA units of inactivated HAV; HAV, hepatitis A virus. ... Climates Humanitarian Aid Workers Humanitarian Aid Organizations During Ebola Outbreak Ebola Outbreak: Advice for Humanitarian Aid Workers ...

239

Protect Yourself from Hepatitis  

MedlinePLUS

... a completely different disease. Flu is caused by viruses that attack your lungs and respiratory system; hepatitis ... leave you needing a new liver. Several different viruses—named the hepatitis A, B, C, D and ...

240

Radiotherapy of Painful Vertebral Hemangiomas: The Single Center Retrospective Analysis of 137 Cases  

SciTech Connect

Purpose: An evaluation of dose-response relationship and an attempt to define predictive factors. Methods and Materials: A total of 137 cases of painful vertebral hemangioma irradiations (101 patients). Fraction dose (fd) varied from 2 to 15 Gy (123 fractionated and 14 radiosurgical treatments), and total dose (TD) from 8 to 30 Gy (111 cases irradiated with fd of 2 GY to TD of 24 Gy). We evaluated pain relief, changes in analgesic requirements, and reossification. Results: Means of pain relief 1, 6, 12, and 18 months after radiotherapy (defined as a decrease of primary pain level expressed in percent) were 60.5%, 65.4%, 68.3%, and 78.4%, respectively. Proportion of patients with no need for analgesics and patients using tramadol were 39%, 40%, 44%, 57%, and 20%, 17%, 22%, and 11% in these times. The proportion of patients experiencing complete/partial pain relief changed from 36/48% 1 month, to 64/22% 1.5 years after radiotherapy. No impact of radiotherapy on reossification was found. The positive impact of fd and TD increase for analgesics uptake reduction and pain relief was found. An increase of the fd by 1 Gy results in 27% chance of analgesics uptake reduction and 3.8% reduction of pain, whereas 14% analgesics uptake reduction and 2.2% of pain reduction in case of the TD. The predictive factors improving results were found: female gender, older age, better performance states (the chance of the lower analgesic treatment decreases over 2.5 times in comparison to the higher Zubrod degree), bigger Hb concentration, shorter symptoms duration and lower analgesics uptake before radiotherapy. Conclusions: The obtained data support the efficacy of radiotherapy in improving pain secondary to vertebral hemangioma, with the degree of pain amelioration being related to increasing fd and TD. The positive predictive factors were defined: female gender, older age, better performance status, increased Hb concentration, shorter symptoms duration, and lower analgesics uptake before radiotherapy.

Miszczyk, Leszek, E-mail: leszek@io.gliwice.pl [Radiotherapy Department, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice (Poland); Tukiendorf, Andrzej [Cardiff Research Consortium, The MediCentre Eastgate House, Cardiff, South Glamorgan (United Kingdom)

2012-02-01

241

The role of ?-adrenergic receptor signaling in the proliferation of hemangioma-derived endothelial cells  

PubMed Central

Background Infantile hemangioma (IH) is a benign vascular neoplasm that arises from the abnormal proliferation of endothelial cells and enhanced angiogenesis. Recently, propranolol has been found to be effective in the management of IH, suggesting that ?-adrenergic receptors (?-ARs) may play an important role in the pathogenesis of IH. Results In the present study, we investigated the ?-adrenergic signaling that is associated with hemangioma-derived endothelial cell (HemEC) proliferation. The results showed that both ?1- and ?2-ARs were expressed in HemECs. Stimulation of the ?-ARs by isoprenaline induced cell proliferation and elevation of second messenger cAMP levels. The proliferation-promoting action of isoprenaline was abolished by a ?1-selective antagonist and was more effectively abolished by a ?2-selective antagonist; the mechanism for the action of the antagonists was a G0/G1 phase cell cycle arrest which was associated with decreased cyclin D1, CDK-4, CDK-6 and phospho-Rb expression. Pre-treatment of the cells with VEGFR-2 or ERK inhibitors also prevented the isoprenaline-mediated proliferation of cells. In agreement with the involvement of ?-ARs and VEGFR-2 in the HemEC response, ?-AR antagonists and the VEGFR-2 inhibitor significantly attenuated isoprenaline-induced ERK phosphorylation. Moreover, treating the cells with isoprenaline markedly increased VEGF-A expression and VEGFR-2 activity in a ?2-AR-dependent manner. Conclusions We have demonstrated that the activation of the ?-ARs in the ERK pathway may be important mechanisms in promoting HemEC growth. Furthermore, stimulation of the ?-AR may transactivate VEGFR-2 signaling and further increase HemEC proliferation. PMID:23286511

2013-01-01

242

Erythropoietic and hepatic porphyrias  

Microsoft Academic Search

Porphyrias are divided into erythropoietic and hepatic manifestations. Erythropoietic porphyrias are characterized by cutaneous symptoms and appear in early childhood. Erythropoietic protoporphyria is complicated by cholestatic liver cirrhosis and progressive hepatic failure in 10% of patients. Acute hepatic porphyrias (d-aminolaevulinic acid dehydratase deficiency porphyria, acute intermittent porphyria, hereditary coproporphyria and variegate porphyria) are characterized by variable extrahepatic gastrointestinal, neurological–psychiatric and

U. Gross; G. F. Hoffmann; M. O. Doss

2000-01-01

243

Human hereditary hepatic porphyrias  

Microsoft Academic Search

The human hereditary hepatic porphyrias are diseases due to marked deficiencies of enzymes in the heme biosynthetic pathway. Porphyrias can be classified as either hepatic or erythroid, depending on the major production site of porphyrins or their precursors. The pathogenesis of inherited hepatic porphyrias has now been defined at the molecular level. Some gene carriers are vulnerable to a range

Yves Nordmann; Hervé Puy

2002-01-01

244

Congenital giant megaureter.  

PubMed

We have seen 21 patients with unilateral congenital giant megaureter. Age ranged from 2 months to 8 years. This condition is characterized by giant focal segmental ureteral dilatation producing an elongated and distorted ureter; distally there may be congenital ureteral stenosis or atresia, or a ureter of approximately normal caliber. They usually have a dysplastic and disorganized muscular coat, lined with a columnar epithelial mucosa rather than the usual transitional epithelium. The associated kidney or moiety was hypoplastic, dysplastic, or the site of comparatively mild hydronephrosis associated with atrophic renal parenchyma. Function and volume of the bladder was normal. Twelve of 21 patients had a duplex collecting system on the affected side. One patient had four pelves and proximal ureters opening into a single lower ureter, which was the site of a giant cyst. One of eight simple giant megaureters was suspected of being associated with a solitary kidney. Depending on whether the giant segmental ureteral dilatation was multiple or single, these cases have presented either with marked protruberance of the mid and lower abdomen, which was distended by transverse elongated cysts, or with a round cyst mass in the lower abdomen. Nineteen patients treated by excision of the giant megaureter and the associated kidney or moiety were free of symptoms postoperatively. One 4-month-old infant with multiple congenital abnormalities and urinary tract infections died soon after operation. Another 4-month-old infant with suspected solitary kidney was treated by ureterostomy and was discharged in a critical condition without follow-up. PMID:3559867

Huang, C J

1987-03-01

245

Giant perigenital seborrheic keratosis  

PubMed Central

Seborrheic keratosis (SK) is a very common benign epidermal proliferation that is prevalent in all races. Most commonly occurring on the trunk, face, scalp, and the extremities, they can occur anywhere on the body except the palms and soles. The most common appearance is that of a very superficial verrucous plaque which appears to be stuck on the surface. Giant lesions are very rare, and their location on the genital area is rarer still. We report here a case of multiple giant SK lesions in a 59-year-old man.

Bandyopadhyay, Debabrata; Saha, Abanti; Mishra, Vivek

2015-01-01

246

An innocent giant.  

PubMed

A cutaneous horn (cornu cutaneum) is a protrusion from the skin composed of a cornified material. It may be associated with a benign, premalignant, or malignant lesion at the base, masking numerous dermatoses. In a 24-year-old female, a giant cutaneous horn arising from a seborrheic keratosis located on the leg is presented. This case has been reported to emphasize that a giant cutaneous horn may also occur in young patients, even in photoprotected areas, and are not always associated with malignancy. PMID:25484426

Solanki, Lakhan Singh; Dhingra, Mandeep; Raghubanshi, Gunjan; Thami, Gurvinder Pal

2014-11-01

247

[Epidemiology of viral hepatitis].  

PubMed

Understanding the country-specific epidemiology of disease, which may vary greatly among countries, is crucial for identifying the most appropriate preventive and control measures. An overview of the local epidemiology of viral hepatitis in Croatia is given in this paper. The overall prevalence of hepatitis B in Croatia is low (less than 2% HBsAg carriers in the general population). Hepatitis B incidence and prevalence began to decline significantly following the introduction of universal hepatitis B vaccination in 1999. Information on HBsAg seroprevalence is derived from routine testing of certain subpopulations (pregnant women, blood donors) and seroprevalence studies mostly targeted at high-risk populations. Universal childhood vaccination against hepatitis B remains the main preventive measure. We recommend testing for immunity one to two months after the third dose of hepatitis B vaccine for health-care workers. The incidence and prevalence of hepatitis C have also been declining in the general population. The main preventive measures are ensuring safety of blood products, prevention of drug abuse, and harm reduction programs for intravenous drug users. Hepatitis A incidence has declined dramatically since fifty years ago, when thousands of cases were reported annually. In the last five years, an average of twenty cases have been reported per year. The reduction of hepatitis A is a consequence of improved personal and community hygiene and sanitation. Hepatitis D has not been reported in Croatia. The risk of hepatitis D will get to be even smaller as the proportion of population vaccinated against hepatitis B builds up. Hepatitis E is reported only sporadically in Croatia, mostly in persons occupationally in contact with pigs and in travelers to endemic countries. In conclusion, Croatia is a low prevalence country for hepatitides A, B and C. Hepatitis D has not been reported to occur in Croatia and there are only sporadic cases of hepatitis E. Since hepatitis A is a rare disease occurring sporadically, which is a consequence of improved sanitation and hygiene, hepatitides B and C are the main causes of viral hepatitis in Croatia. The introduction of universal mandatory hepatitis B vaccination of schoolchildren in 1999 resulted in a decrease in the incidence of hepatitis B, which is most pronounced in adolescents and young adults, and further decrease in the incidence and prevalence is expected as the pool of susceptible individuals decreases through vaccination. The incidence of hepatitis C is decreasing as well. In spite of a relatively favorable epidemiological situation, hepatitis B and C are still a significant public health burden with an estimated 25,000 persons chronically infected with HBV and about 40,000 persons chronically infected with HCV in Croatia. PMID:24984326

Kai?, Bernard; Vilibi?-Cavlek, Tatjana; Filipovi?, Sanja Kureci?; Nemeth-Blazi?, Tatjana; Pem-Novosel, Iva; Vucina, Vesna Visekruna; Simunovi?, Aleksandar; Zajec, Martina; Radi?, Ivan; Pavli?, Jasmina; Glamocanin, Marica; Gjenero-Margan, Ira

2013-10-01

248

Intractable hiccup as the presenting symptom of cavernous hemangioma in the medulla oblongata: a case report and literature review.  

PubMed

A case of intractable hiccup developed by cavernous hemangioma in the medulla oblongata is reported. There have been only five previously reported cases of medullary cavernoma that triggered intractable hiccup. The patient was a 28-year-old man who was presented with intractable hiccup for 15 days. It developed suddenly, then aggravated progressively and did not respond to any types of medication. On magnetic resonance images, a well-demarcated and non-enhancing mass with hemorrhagic changes was noted in the left medulla oblongata. Intraoperative findings showed that the lesion was fully embedded within the brain stem and pathology confirmed the diagnosis of cavernous hemangioma. The hiccup resolved completely after the operation. Based on the presumption that the medullary cavernoma may trigger intractable hiccup by displacing or compression the hiccup arc of the dorsolateral medulla, surgical excision can eliminate the symptoms, even in the case totally buried in brainstem. PMID:25237438

Lee, Kyung-Hwa; Moon, Kyung-Sub; Jung, Min-Young; Jung, Shin

2014-06-01

249

Intractable Hiccup as the Presenting Symptom of Cavernous Hemangioma in the Medulla Oblongata: A Case Report and Literature Review  

PubMed Central

A case of intractable hiccup developed by cavernous hemangioma in the medulla oblongata is reported. There have been only five previously reported cases of medullary cavernoma that triggered intractable hiccup. The patient was a 28-year-old man who was presented with intractable hiccup for 15 days. It developed suddenly, then aggravated progressively and did not respond to any types of medication. On magnetic resonance images, a well-demarcated and non-enhancing mass with hemorrhagic changes was noted in the left medulla oblongata. Intraoperative findings showed that the lesion was fully embedded within the brain stem and pathology confirmed the diagnosis of cavernous hemangioma. The hiccup resolved completely after the operation. Based on the presumption that the medullary cavernoma may trigger intractable hiccup by displacing or compression the hiccup arc of the dorsolateral medulla, surgical excision can eliminate the symptoms, even in the case totally buried in brainstem. PMID:25237438

Lee, Kyung-Hwa; Jung, Min-Young; Jung, Shin

2014-01-01

250

Clinical observation on the treatment of hemangioma by CO2 laser supplemented with He-Ne laser  

Microsoft Academic Search

Sixty-six cases of hemangioma were treated with CO2 laser alone (22 cases as a control group), or CO2 laser supplemented with He-Ne laser (44 cases of the treated group). Optimum power dosage was first sought on normal volunteers. Arteriolar vasculature and lymphatics were blocked 3 - 5 times with procaine hydrochloride (5:1) to minimize local blood congestion. Results show that

Zhigui Zhao

1993-01-01

251

Simultaneous diagnosis of ipsilateral adenoid cystic carcinoma of the lacrimal gland and orbital cavernous hemangioma: case report.  

PubMed

To describe a patient with coexistence of ipsilateral adenoid cystic carcinoma of the lacrimal gland and orbital cavernous hemangioma. The patient presented a 2-month history of painful swelling of left upper eyelid, which did not resolve on a course of oral steroid. On clinical examination, she had moderate medial and inferior dislocation of the eye globe, edema of the temporal superior eyelid and moderate restriction upgaze. Magnetic resonance imaging identified two left orbital tumors: one was a lesion that arose from the lacrimal gland, and the second was a well-defined, ovoid, intraconal mass. The patient underwent lateral orbitotomy and excision of both lesions. Postoperative histological features demonstrated two different lesions: an adenoid cystic carcinoma of the lacrimal gland and a cavernous hemangioma. The clinical presentation of the present case was strongly suggestive of a lacrimal gland malignancy, although the imaging features did not show typical invasive aspects. This is the first report of coexistence of lacrimal gland adenoid cystic carcinoma and cavernous hemangioma in the ipsilateral orbit. PMID:24786224

Strianese, Diego; Ferrara, Mariantonia; Iuliano, Adriana; Bonavolontà, Giulio

2014-08-01

252

Finite size giant magnon  

SciTech Connect

The quantization of the giant magnon away from the infinite size limit is discussed. We argue that this quantization inevitably leads to string theory on a Z{sub M} orbifold of S{sup 5}. This is shown explicitly and examined in detail in the near plane-wave limit.

Ramadanovic, Bojan; Semenoff, Gordon W. [Department of Physics and Astronomy, University of British Columbia, Vancouver, British Columbia, V6T 1Z1 (Canada)

2009-06-15

253

Birth control for giants  

Microsoft Academic Search

The standard Erdýos-Renyi model of random graphs begins with n isolated vertices, and at each round a random edge is added. Parametrizing n 2 rounds as one time unit, a phase transition occurs at t = 1 when a giant component (one of size constant time n) first appears. Under the influence of statistical mechanics, the investigation of related phase

Joel H. Spencer; Nicholas C. Wormald

2007-01-01

254

Extracranial vascular malformations (hemangiomas and vascular malformations) in children and adolescents – diagnosis, clinic, and therapy  

PubMed Central

The field of extracranial vascular anomalies is considered as special focus of pediatric otolaryngology and it has shown a rapid development during the last years. The reason for this interest is finally also due to the global acceptance of the classification introduced by the ISSVA (International Society for the Study of Vascular Anomalies). Hemangiomas are the most frequently observed vascular tumors. Today the systemic propranolol therapy is mostly used for therapy of hemangiomas requiring treatment. Increasingly, the topical application of beta blocker is discussed while the benefit in the head and neck seems to be limited. Vascular malformations are classified according to the morphology of the affected part of the vascular system in arterial, venous, arterio-venous, lymphatic, capillary, and combined vascular malformations. Conventional surgery, sclerosing therapy, and laser treatment are invasive options for the treatment of lymphatic malformations. The options for the treatment of venous malformations could be significantly improved during the last years. In this context, the use of Nd:YAG laser, the conservative treatment of the localized disseminated intravascular coagulation with low-molecular weight heparin, the re-discovery of bleomycin as effective sclerosing agent, and the improvement of alcohol-based embolization agents must be mentioned. Today the treatment with dye laser is the preferred therapy for capillary malformations and it is superior to other therapeutic options as for example photodynamic therapy. Arterio-venous malformations as representatives for high-flow lesions are the high-risk lesions. Frequently they are compared to malignant head and neck tumors, in particular when a curative treatment can no longer be assured because of diffuse or multifocal extent and when the disease shows a progressive course. The combined treatment of embolization and surgical resection and if necessary consecutive defect reconstruction have turned out to be appropriate for arterio-venous malformations. Incurable findings are still a major challenge. Despite the introduction of antiangiogenetic drugs in oncology, the medicamentous therapeutic approach could not be established for arterio-venous malformations up to now. PMID:25587362

Eivazi, Behfar; Werner, Jochen A.

2014-01-01

255

[Giant papillary conjunctivitis].  

PubMed

Giant papillary conjunctivitis is an inflammation of the conjunctiva, which is associated with immunological-allergic disorders, but is difficult to integrate as a defined type of illness. The deposits of contact lenses are responsible in predisposed wearers. They induce a special immune answer to their biochemical ingredients. In addition, roughness of the superficial corneal layers and the conjunctiva, even without any contact lenses after filtrating glaucoma surgery, leads to mechanically induced papillary formations. In former days these symptoms of building giant papillae were seen mostly in wearers of soft hydrogel contact lenses. Nowadays manufacturers have developed contact lens systems with a variety of material components, with an increase of protein and lipid deposits. In combination with the observed non-compliance of wearers regarding lens exchange and contact lens hygiene, GPC is an issue which should be taken into consideration again. PMID:24799171

Bischoff, G

2014-05-01

256

Paediatric giant cervicomediastinal thymolipoma.  

PubMed

We report a case of a 11-year-old boy who presented with a massive soft tissue right cervical painless and progressive lesion displacing trachea to the left and extending into the anteriosuperior mediastinum which was diagnosed to be a lipomatous mass on chest CT scan. Subsequent biopsy and total excision proved it to be a giant cervicomediastinal thymolipoma. It was successfully excised with excellent prognosis and long-term results. A giant paediatric cervicomediastinal thymolipoma is a rare, benign, mediastinal mass of thymic origin. It may remain asymptomatic despite massive size and up to 50% in some series are associated with autoimmune disease. CT scan gives fat density and encapsulated benign nature and biopsy usually establishes the diagnosis. Preoperative tissue diagnosis is important as now the availability of thoracoscopic option is best suited to reduce morbidity. Treatment of choice is total excision using open surgical, minimal invasive techniques or robotic surgery and the prognosis is excellent. PMID:24849642

Patel, Ramnik V; Evans, Kathryn; Sau, Indranil; Huddart, Simon

2014-01-01

257

Autophagy in Hepatic Fibrosis  

PubMed Central

Hepatic fibrosis is a leading cause of morbidity and mortality worldwide. Hepatic fibrosis is usually associated with chronic liver diseases caused by infection, drugs, metabolic disorders, or autoimmune imbalances. Effective clinical therapies are still lacking. Autophagy is a cellular process that degrades damaged organelles or protein aggregation, which participates in many pathological processes including liver diseases. Autophagy participates in hepatic fibrosis by activating hepatic stellate cells and may participate as well through influencing other fibrogenic cells. Besides that, autophagy can induce some liver diseases to develop while it may play a protective role in hepatocellular abnormal aggregates related liver diseases and reduces fibrosis. With a better understanding of the potential effects of autophagy on hepatic fibrosis, targeting autophagy might be a novel therapeutic strategy for hepatic fibrosis in the near future. PMID:24779010

Zhao, Yingying; Wang, Fei; Tao, Lichan; Yang, Changqing

2014-01-01

258

Voyager: Giant Kelp  

NSDL National Science Digital Library

The Birch Aquarium at Scripps Institution of Oceanography offers this Web site as part of the Aquarium's online educational series, Voyager Science. Geared toward younger kids, this site introduces the kelp forest and related concepts with great photos, informative descriptions, and a few interactive activities. Giant Kelp focuses on the kelp plant itself, including the many (and often surprising) commercial uses of kelp products. Simple at-home experiments and online activities are also included.

Criqui, Nan

259

Giant adrenal myelolipoma  

PubMed Central

A fifty-two years old male presenting with a history of abdominal pain of six months duration was found on investigation to have a large non-functioning adrenal mass. Adrenal myelolipoma was diagnosed preoperatively and surgical resection was carried out. Only a small number of cases of giant adrenal myelolipoma (>3500 grams) have been reported. A brief review of literature is done. PMID:25003051

Gautam, S.C.; Raafat, H.; Sriganesh, S.; Zaffar, I.; Olude, I.; Komolafe, F.; Qazi, F.

2013-01-01

260

Giant adrenal myelolipoma.  

PubMed

A fifty-two years old male presenting with a history of abdominal pain of six months duration was found on investigation to have a large non-functioning adrenal mass. Adrenal myelolipoma was diagnosed preoperatively and surgical resection was carried out. Only a small number of cases of giant adrenal myelolipoma (>3500 grams) have been reported. A brief review of literature is done. PMID:25003051

Gautam, S C; Raafat, H; Sriganesh, S; Zaffar, I; Olude, I; Komolafe, F; Qazi, F

2013-01-01

261

Hot giant loop holography  

SciTech Connect

We argue that there is a phase transition in the expectation value of the Polyakov loop operator in the large N limit of the high temperature deconfined phase of N=4 Yang-Mills theory on a spatial S{sup 3}. It occurs for the large completely symmetric representation of the SU(N) symmetry group. We speculate that this transition is reflected in the D-branes which are the string theory duals of giant loops.

Grignani, Gianluca [Dipartimento di Fisica, Universita di Perugia, INFN Sezione di Perugia, Via A. Pascoli, 06123 Perugia (Italy); Karczmarek, Joanna L.; Semenoff, Gordon W. [Department of Physics and Astronomy, University of British Columbia, Vancouver, British Columbia V6T 1Z1 (Canada)

2010-07-15

262

Iron and hepatitis C  

Microsoft Academic Search

Serum iron markers are often elevated in hepatitis C virus infection, particularly in African-American persons, although the\\u000a clinical significance of this finding remains unclear. Although hepatic iron is usually only mildly elevated in hepatitis\\u000a C virus, iron overload is associated with more advanced disease, nonresponse to interferon monotherapy, and increased risk\\u000a of hepatocellular carcinoma. Iron status does not predict response

James E. Nelson; Kris V. Kowdley

2004-01-01

263

Hepatic manifestations of celiac disease  

PubMed Central

Different hepatic and biliary tract disorders may occur with celiac disease. Some have been hypothesized to share genetic or immunopathogenetic factors, such as primary biliary cirrhosis, primary sclerosing cholangitis, and autoimmune hepatitis. Other hepatic changes in celiac disease may occur with malnutrition resulting from impaired nutrient absorption, including hepatic steatosis. In addition, celiac disease may be associated with rare hepatic complications, such as hepatic T-cell lymphoma. PMID:21694844

Freeman, Hugh James

2010-01-01

264

Lesion discrimination with breath-hold hepatic diffusion-weighted imaging: A meta-analysis  

PubMed Central

AIM: To investigate the diagnostic capability of breath-hold diffusion-weighted imaging (DWI) for differentiation between malignant and benign hepatic lesions. METHODS: A total of 614 malignant liver lesions (132 hepatocellular carcinomas, 468 metastases and 14 intrahepatic cholangiocarcinomas) and 291 benign liver lesions (102 hemangiomas, 158 cysts, 24 focal nodular hyperplasia, 1 angiomyolipoma and 6 hepatic adenomas) were included from seven studies (eight sets of data). RESULTS: The pooled sensitivity and specificity of breath-hold DWI were 0.93 [95% confidence interval (CI): 0.91-0.95] and 0.87 (95%CI: 0.83-0.91), respectively. The positive likelihood ratio and negative likelihood ratio were 7.28 (95%CI: 4.51-11.76) and 0.09 (95%CI: 0.05-0.17), respectively. The P value for ?2 heterogeneity for all pooled estimates was < 0.05. From the fitted summary receiver operating characteristic curve, the area under the curve and Q* index were 0.96 and 0.91, respectively. Publication bias was not present (t = 0.49, P = 0.64). The meta-regression analysis indicated that evaluated covariates including magnetic resonance imaging modality, echo time, mean age, maximum b factor, and number of b factors were not sources of heterogeneity (all P > 0.05). CONCLUSION: Breath-hold DWI is useful for differentiating between malignant and benign hepatic lesions. The diffusion characteristics of benign lesions that mimic malignant ones have rarely been investigated.

Chen, Zhi-Guang; Xu, Li; Zhang, Si-Wei; Huang, Yan; Pan, Rui-Huan

2015-01-01

265

Glucose transporter 1-positive endothelial cells in infantile hemangioma exhibit features of facultative stem cells.  

PubMed

Endothelial glucose transporter 1 (GLUT1) is a definitive and diagnostic marker for infantile hemangioma (IH), a vascular tumor of infancy. To date, GLUT1-positive endothelial cells in IH have not been quantified nor directly isolated and studied. We isolated GLUT1-positive and GLUT1-negative endothelial cells from IH specimens and characterized their proliferation, differentiation, and response to propranolol, a first-line therapy for IH, and to rapamycin, an mTOR pathway inhibitor used to treat an increasingly wide array of proliferative disorders. Although freshly isolated GLUT1-positive cells, selected using anti-GLUT1 magnetic beads, expressed endothelial markers CD31, VE-Cadherin, and vascular endothelial growth factor receptor 2, they converted to a mesenchymal phenotype after 3 weeks in culture. In contrast, GLUT1-negative endothelial cells exhibited a stable endothelial phenotype in vitro. GLUT1-selected cells were clonogenic when plated as single cells and could be induced to redifferentiate into endothelial cells, or into pericytes/smooth muscle cells or into adipocytes, indicating a stem cell-like phenotype. These data demonstrate that, although they appear and function in the tumor as bona fide endothelial cells, the GLUT1-positive endothelial cells display properties of facultative stem cells. Pretreatment with rapamycin for 4 days significantly slowed proliferation of GLUT1-selected cells, whereas propranolol pretreatment had no effect. These results reveal for the first time the facultative nature of GLUT1-positive endothelial cells in IH. Stem Cells 2015;33:133-145. PMID:25187207

Huang, Lan; Nakayama, Hironao; Klagsbrun, Michael; Mulliken, John B; Bischoff, Joyce

2015-01-01

266

Radiotherapy for Symptomatic Vertebral Hemangiomas: Results of a Multicenter Study and Literature Review  

SciTech Connect

Purpose: The current study analyzes the potential role of radiotherapy (RT) in symptomatic vertebral hemangioma (SVH). Methods and Materials: Seven cooperating German institutions collected clinical information, treatment plans, and outcome data for all patients with SVH referred for local RT. Results: From 1969 to 2008, a total of 84 patients with 96 symptomatic lesions were irradiated for SVH. The primary indication for radiotherapy was pain (97.6%), and 28.6% of patients had additional neurological symptoms. RT was performed at a median total dose of 34 Gy, with a median single dose of 2.0 Gy. After receiving a median follow-up of 68 months, the overall patient response rate was 90.5%. Complete symptom remission occurred in 61.9% of patients, 28.6% of patients had partial pain relief, and 9.5% of patients had no pain relief. In 26.2% of patients, radiological signs of reossification were observed in long-term follow-up but not significantly correlated with pain relief. Most importantly, total doses of >=34 Gy resulted in significantly greater symptomatic relief and control rate than total doses of <34 Gy. Conclusions: This study consists of the largest database of cases reported so far using RT for SVH. RT is easy, safe, and effective for pain relief treatment for SVH. Total doses of at least 34 Gy give the best symptomatic response.

Heyd, Reinhard [Department of Radiotherapy, Offenbach Hospital, Offenbach (Germany); Seegenschmiedt, M. Heinrich [Department of Radiation Oncology, Alfried Krupp Hospital, Essen (Germany); Rades, Dirk [Department of Radiation Oncology, University Hospital Eppendorf, Hamburg (Germany); Winkler, Cornelia [Department of Radiotherapy, Carl Gustav Carus University Hospital, Dresden (Germany); Eich, Hans T. [Department of Radiotherapy, University Hospital, Cologne (Germany); Bruns, Frank [Department of Radiotherapy and Special Oncology, University Hospital, Hannover (Germany); Gosheger, Georg [Department of General and Surgical Orthopedics, University Hospital, Muenster (Germany); Willich, Normann [Department of Radiation Oncology, University Hospital, Muenster (Germany); Micke, Oliver, E-mail: omicke@benign-news.d [Department of Radiation Oncology, University Hospital, Muenster (Germany); Department of Radiotherapy and Radiation Oncology, Franziskus Hospital, Bielefeld (Germany)

2010-05-01

267

Pericytes from Infantile Hemangioma Display Pro-angiogenic Properties and Dysregulated Angiopoietin-1  

PubMed Central

OBJECTIVE Infantile hemangioma (IH) is a rapidly growing vascular tumor affecting newborns. It is composed of immature endothelial cells and pericytes that proliferate into a disorganized mass of blood vessels. We isolated pericytes from IH (Hem-pericytes) to test our hypothesis that Hem-pericytes are unable to stabilize blood vessels. METHODS AND RESULTS We injected pericytes in vivo, in combination with endothelial cells, and found that Hem-pericytes formed more microvessels compared to control retinal pericytes. We thereby analyzed pro-angiogenic properties of the Hem-pericytes. They grew fast in vitro, and were unable to stabilize endothelial cell growth and migration, and expressed high levels of VEGF-A compared to retinal pericytes. Hem-pericytes from proliferating phase IH showed lower contractility in vitro, compared to Hem-pericytes from the involuting phase and retinal pericytes. Consistent with a diminished ability to stabilize endothelium, Angiopoietin 1 (ANGPT1) was reduced in Hem-pericytes compared to retinal pericytes. Normal retinal pericytes in which ANGPT1 was silenced produced conditioned medium that stimulated endothelial cell proliferation and migration. CONCLUSIONS We report the first successful isolation of patient-derived pericytes from IH tissue. Hem-pericytes exhibited pro-angiogenic properties and low levels of ANGPT1, consistent with a diminished ability to stabilize blood vessels in IH. PMID:23288163

Boscolo, Elisa; Mulliken, John B.; Bischoff, Joyce

2013-01-01

268

Laser treatment in the management of infantile hemangiomas and capillary vascular malformations.  

PubMed

Vascular lesions encountered in dermatology can be divided into vascular malformations and vascular tumors, namely infantile hemangiomas (IH). Vascular malformations can further be subdivided by their flow characteristics and vessel type. Slow, or low-flow lesions are either capillary vascular malformations (CVMs), venous malformations, or lymphatic malformations. Fast, or high-flow lesions include an arterial component, and are categorized as arteriovenous malformations. IH and CVMs are among the most common benign vascular lesions seen and treated in dermatology. CVMs are present at birth and grow as the individual does, whereas IH usually appear days to weeks later and may rapidly enlarge for a period of months to a year before gradually involuting. As the technology has evolved, early and often laser treatment with the pulsed dye 595-nm laser has become our standard therapy of choice. More recently, we have started more patients on combination therapy for IH with the topical beta blocker timolol. If left untreated, CVMs darken and thicken, making them increasingly difficult to successfully treat with lasers. IH involute, sometimes resulting in fibrofatty, atrophic plaques. These individuals can undergo ablative fractional resurfacing with a fractional CO2 laser to improve the texture and appearance of these lesions. PMID:23499132

Brauer, Jeremy A; Geronemus, Roy G

2013-03-01

269

ZFP36-FOSB Fusion Defines a Subset of Epithelioid Hemangioma with Atypical Features  

PubMed Central

Epithelioid hemangioma (EH) is a benign neoplasm with distinctive vasoformative features, which occasionally shows increased cellularity, cytologic atypia, and/or loco-regional aggressive growth, resulting in challenging differential diagnosis from malignant vascular neoplasms. Based on two intra-osseous EH index cases with worrisome histologic features, such as the presence of necrosis, RNA sequencing was applied for possible fusion gene discovery and potential subclassification of a novel atypical EH subset. A ZFP36-FOSB fusion was detected in one case, while a WWTR1-FOSB chimeric transcript in the other, both were further validated by FISH and RT-PCR. These abnormalities were then screened by FISH in 44 EH from different locations with 7 additional EH revealing FOSB gene rearrangements, all except one being fused to ZFP36. Interestingly, 4/6 penile EH studied showed FOSB abnormalities. Although certain atypical histologic features were observed in the FOSB-rearranged EH, including solid growth, increased cellularity, mild to moderate nuclear pleomorphism, and necrosis in 3/9 cases, no overt sarcomatous areas were discerned to objectively separate the lesions from the fusion-negative EH. No patient has developed recurrence to date, but the follow-up was relatively limited and short to draw definitive conclusions regarding behavior. Although FOSB-rearranged EH do not show significant morphologic overlap with SERPINE1-FOSB fusion-positive pseudomyogenic hemangioendothelioma, FOSB oncogenic activation is emerging as an important event in these benign and intermediate groups of vascular tumors. PMID:25043949

Antonescu, Cristina R; Chen, Hsiao-Wei; Zhang, Lei; Sung, Yun-Shao; Panicek, David; Agaram, Narasimhan P; Dickson, Brendan C; Krausz, Thomas; Fletcher, Christopher D

2014-01-01

270

Giant European dinosaur found in Spain  

NSDL National Science Digital Library

Fossils of a giant Sauropod, found in Spain, reveal that Europe was home to giant dinosaurs in the Late Jurassic period -- about 150 million years ago. Giant dinosaurs have previously been found mainly in the New World and Africa.

American Association for the Advancement of Science (AAAS; )

2006-12-21

271

Asymptomatic Gastric Perforation by a Toothpick  

Microsoft Academic Search

Background: Many cases of gastric perforation with peritonitis, pylephlebitis, hepatic abscesses, or lethal bleeding, caused by ingested long and sharp objects, are reported in the literature. Methods: During a right hepatectomy for a giant hemangioma, a wooden toothpick was found between the two layers of the hepatogastric ligament. It was not possible to find the passage of the foreign body

Alberto Porcu; Antonio Dessanti; Claudio F. Feo; Giuseppe Dettori

1999-01-01

272

Erythropoietic and hepatic porphyrias.  

PubMed

Porphyrias are divided into erythropoietic and hepatic manifestations. Erythropoietic porphyrias are characterized by cutaneous symptoms and appear in early childhood. Erythropoietic protoporphyria is complicated by cholestatic liver cirrhosis and progressive hepatic failure in 10%, of patients. Acute hepatic porphyrias (delta-aminolaevulinic acid dehydratase deficiency porphyria, acute intermittent porphyria, hereditary coproporphyria and variegate porphyria) are characterized by variable extrahepatic gastrointestinal, neurological-psychiatric and cardiovascular manifestations requiring early diagnosis to avoid life-threatening complications. Acute hepatic porphyrias are pharmacogenetic and molecular regulatory diseases (without porphyrin accumulation) mainly induced by drugs, sex hormones, fasting or alcohol. The disease process depends on the derepression of hepatic delta-aminolaevulinic acid synthase following haem depletion. In contrast to the acute porphyrias, nonacute, chronic hepatic porphyrias such as porphyria cutanea tarda are porphyrin accumulation disorders leading to cutaneous symptoms associated with liver disease, especially caused by alcohol or viral hepatitis. Alcohol, oestrogens, haemodialysis, hepatitis C and AIDS are triggering factors. Porphyria cutanea tarda is the most common porphyria, followed by acute intermittent porphyria and erythropoietic protoporphyria. The molecular genetics of the porphyrias is very heterogenous. Nearly every family has its own mutation. The mutations identified account for the corresponding enzymatic deficiencies, which may remain clinically silent throughout life. Thus, the recognition of the overt disorder with extrahepatic manifestations depends on the demonstration of biochemical abnormalities due to these primary defects and compensatory hepatic overexpression of hepatic delta-aminolaevulinic acid synthase in the acute porphyrias. Consequently, haem precursors are synthesized in excess. The increased metabolites upstream of the enzymatic defect are excreted into urine and faeces. The diagnosis is based on their evaluation. Primary enzymatic or molecular analyses are noncontributary and may be misleading. Acute polysymptomatic exacerbations accompany a high excretory constellation of porphyrin precursors delta-aminolaevulinic acid and porphobilinogen. Homozygous or compound heterozygous variants of acute hepatic porphyrias may already manifest in childhood. PMID:11117426

Gross, U; Hoffmann, G F; Doss, M O

2000-11-01

273

Study on computer-aided diagnosis of hepatic MR imaging and mammography  

SciTech Connect

It is well known that the liver is an organ easily attacked by diseases. The purpose of this study is to develop a computer-aided diagnosis (CAD) scheme for helping radiologists to differentiate hepatic diseases more efficiently. Our software named LIVERANN integrated the magnetic resonance (MR) imaging findings with different pulse sequences to classify the five categories of hepatic diseases by using the artificial neural network (ANN) method. The intensity and homogeneity within the region of interest (ROI) delineated by a radiologist were automatically calculated to obtain numerical data by the program for input signals to the ANN. Outputs were the five pathological categories of hepatic diseases (hepatic cyst, hepatocellular carcinoma, dysplasia in cirrhosis, cavernous hemangioma, and metastasis). The experiment demonstrated a testing accuracy of 93% from 80 patients. In order to differentiate the cirrhosis from normal liver, the volume ratio of left to whole (LTW) was proposed to quantify the degree of cirrhosis by three-dimensional (3D) volume analysis. The liver region was firstly extracted from computed tomography (CT) or MR slices based on edge detection algorithms, and then separated into left lobe and right lobe by the hepatic umbilical fissure. The volume ratio of these two parts showed that the LTW ratio in the liver was significantly improved in the differentiation performance, with (25.6%{+-}4.3%) in cirrhosis versus the normal liver (16.4%{+-}5.4%). In addition, the application of the ANN method for detecting clustered microcalcifications in masses on mammograms was described here as well. A new structural ANN, so-called a shift-invariant artificial neural network (SIANN), was integrated with our triple-ring filter (TRF) method in our CAD system. As the result, the sensitivity of detecting clusters was improved from 90% by our previous TRF method to 95% by using both SIANN and TRF.

Zhang Xuejun [Electronics and Information Systems Engineering Division, Graduate School of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193 (Japan)

2005-04-01

274

Polymyalgia Rheumatica and Giant Cell Arteritis  

MedlinePLUS

Polymyalgia Rheumatica and Giant Cell Arteritis August 2012 Questions and Answers about Polymyalgia Rheumatica and Giant Cell Arteritis This publication contains general information about polymyalgia ...

275

Hepatitis C and Incarceration  

MedlinePLUS

... or other equipment, including cookers, cottons, ties, or water to inject drugs. • Do not share razors, toothbrushes, ... t cleaning kill the Hepatitis C virus? Bleaching, boiling, ... infected with the Hepatitis C virus at some point in time. If this test is positive for ...

276

Enteric hepatitis viruses  

PubMed Central

Hepatitis viruses are infectious agents that can infect liver and cause inflammation. The infection triggers immune response against infected cells that leads to the destruction of hepatic cells. This destruction has two consequences: leaking ALT and AST liver enzymes which increases during the course of disease and accumulation of bilirubin- a red pigmented compound released from dead red cells- which causes the yellow coloration of eyes and skin. These viruses transmit through diverse routes i.e. blood transfusion, sexual contacts and consuming water or food contaminated by feces. Enteric hepatitis viruses use the latter route for transmission; hence their outbreaks are more common in underdeveloped countries. There are currently two distinguished enteric hepatitis viruses, hepatitis A and hepatitis E. These viruses belong to different family of viruses and their epidemiological characteristics are different. These infections can be diagnosed by an ELISA for IgM antibody. A vaccine has been developed in last decade of twentieth century for hepatitis A virus, which is administered mostly in the developed world i.e. U.S and Japan. Treatment for these infections is mostly supportive; however, in the case of fulminant hepatitis the liver transplantation might be necessary. PMID:24834192

Tahaei, Seyed Mohammad Ebrahim; Zali, Mohammad Reza

2012-01-01

277

Hepatic porphyrias in children  

Microsoft Academic Search

Clinically overt hepatic porphyria is uncommon in children. The autosomal dominant acute hepatic porphyrias, acute intermittent porphyria (AIP), variegate porphyria (VP) and hereditary coproporphyria (HCP), are rarely present before puberty. Identification of asymptomatic children who have inherited these disorders is an important aspect of the management of the disease in their families and requires either enzymatic or DNA methods. Homozygous

G. H. Elder

1997-01-01

278

Hepatitis G virus  

PubMed Central

A number of new hepatitis viruses (G, TT, SEN) were discovered late in the past century. We review the data available in the literature and our own findings suggesting that the new hepatitis G virus (HGV), disclosed in the late 1990s, has been rather well studied. Analysis of many studies dealing with HGV mainly suggests the lymphotropicity of this virus. HGV or GBV-C has been ascertained to influence course and prognosis in the HIV-infected patient. Until now, the frequent presence of GBV-C in coinfections, hematological diseases, and biliary pathology gives no grounds to determine it as an “accidental tourist” that is of no significance. The similarity in properties of GBV-C and hepatitis C virus (HCV) offers the possibility of using HGV, and its induced experimental infection, as a model to study hepatitis C and to develop a hepatitis C vaccine. PMID:18720531

Reshetnyak, Vasiliy Ivanovich; Karlovich, Tatiana Igorevna; Ilchenko, Ljudmila Urievna

2008-01-01

279

Cavernous hemangioma of the cavernous sinus misdiagnosed as a meningioma: a case report and MR imaging findings.  

PubMed

Cavernous hemangioma (CH) is a benign vascular malformation. Intracranial CH is generally localized as an intracranial-intraaxial and responsible for 5-13% of all intracranial vascular malformations. Intracranial-extraaxial CHs are rare rather than intracranial-intraaxial CHs. Clinical findings, imaging characteristics, and surgical approach of extraaxial CHs are rather different than intraaxial CHs. Diagnosing cavernous sinus CH preoperatively is very important, but its radiological differential diagnosis is quite difficult. In this study, we present magnetic resonance imaging findings of a 48-year-old male who was considered preoperatively to have meningioma but was diagnosed with cavernous sinus CH during surgery by pathological examination. PMID:23453537

Hasiloglu, Zehra Isik; Asik, Murat; Kizilkilic, Osman; Albayram, Sait; Islak, Civan

2013-01-01

280

Purely Cutaneous Rosai-Dorfman disease (CRDD) co-existed with capillary hemangioma successfully treated with intralesional corticosteroid.  

PubMed

Rosai-Dorfminan disease (RDD), or sinus histiocytosis with massive lymphadenopathy, is a benign idiopathic proliferative disorder of the histiocyte. Purely Cutaneous Rosai-Dorfman disease (CRDD) is a separated clinical entity without lymph node and organ involvement. The histologic features resemble RDD, but with dermal infiltration. This rare condition is benign and mostly self-limited The authors report a 66-year-old Thai male patient, diagnosed as purely CRDD, with co-existing capillary hemangioma. In addition, we show that the treatment intralesional corticosteroid can produce the remission of the plaque and tumoral types of this condition. PMID:24164002

Asawabenjang, Wanlapa; Jerasutus, Suthep; Kattipathanapong, Pinnaree; Janjumratsang, Patcharin; Tangjaturonrusamee, Chinmanat

2013-09-01

281

Giant resonances in Mg-24  

E-print Network

The giant resonance region in Mg-24 was studied with inelastic scattering of 240 MeV alpha particles at small angles including 0 degrees. The giant resonance peak was found to extend up to E-X = 41 MeV. Isoscalar E0, E1, and E2 strength...

Youngblood, David H.; Lui, YW; Clark, HL.

1999-01-01

282

Giant hydronephrosis mimicking echinococcal cyst.  

PubMed

Cases of giant hydronephrosis are rare and usually contain no more than one to two liters of fluid in the collecting system. We report a remarkable case of giant hydronephrosis of > 17.5 Kg mimicking a huge echinococcal cyst. PMID:16453224

El Fortia, M; Bendaoud, M; Badi, H; Abufalgha, F; Elgsier, N; Hajaji, E; Abubaker, G

2005-12-01

283

In Search of Giant Squid  

NSDL National Science Digital Library

This site, an online exhibition from the Smithsonian Institution's National Museum of Natural History (NMNH), provides a wealth of background information on Giant Squids. The largest invertebrates on the planet, Giant Squids have aroused human curiosity for centuries. This site offers a plethora of general information about squids and includes a long list of squid links as well.

284

Rare case of a solitary huge hepatic cystic lymphangioma  

PubMed Central

A hepatic lymphangioma is a rare benign neoplasm and is usually associated with lymphangiomas of other viscera. A hepatic lymphangioma can be solitary, cystic or associated with multiple liver lesions and is characterized by cystic dilatation of lymphatic vessels in the hepatic parenchyma. A solitary lymphangioma is unusual. Here we report a rare case of a solitary huge primary hepatic cystic lymphangioma in a 42-year-old woman. It was discovered on routine physical examination and the patient had no obvious symptoms. Ultrasonography and computed tomography (CT) showed a gianthepatic neoplasm” that occupied the right liver lobe. The lesion was approximately 20.0 cm × 15.0 cm × 10.0 cm in size and contained cystic and solid components. There were multiple septa inside the tumor, with some calcifications in the septa. Surgical resection was performed. Histological examination revealed multiple cystic structures lined with epithelial cells on the inner walls, accompanied by interstitial swelling and necrosis. The patient has now been followed up for nearly two years after surgery, with no recurrence to date. PMID:24303489

Zhang, Ya-Zhou; Ye, Yan-Shuo; Tian, Li; Li, Wei

2013-01-01

285

Gas Giants Form Quickly  

NASA Technical Reports Server (NTRS)

This is an artist's concept of a hypothetical 10-million-year-old star system. The bright blur at the center is a star much like our sun. The other orb in the image is a gas-giant planet like Jupiter. Wisps of white throughout the image represent traces of gas.

Astronomers using NASA's Spitzer Space Telescope have found evidence showing that gas-giant planets either form within the first 10 million years of a sun-like star's life, or not at all. The lifespan for sun-like stars is about 10 billion years.

The scientists came to this conclusion after searching for traces of gas around 15 different sun-like stars, most with ages ranging from 3 million to 30 million years. With the help of Spitzer's Infrared Spectrometer instrument, they were able to search for relatively warm gas in the inner regions of these star systems, an area comparable to the zone between Earth and Jupiter in our own solar system. They also used ground-based radio telescopes to search for cooler gas in the outer regions of these systems, an area comparable to the zone around Saturn and beyond.

2007-01-01

286

Rheology of giant micelles  

E-print Network

Giant micelles are elongated, polymer-like objects created by the self-assembly of amphiphilic molecules (such as detergents) in solution. Giant micelles are typically flexible, and can become highly entangled even at modest concentrations. The resulting viscoelastic solutions show fascinating flow behaviour (rheology) which we address theoretically in this article at two levels. First, we summarise advances in understanding linear viscoelastic spectra and steady-state nonlinear flows, based on microscopic constitutive models that combine the physics of polymer entanglement with the reversible kinetics of self-assembly. Such models were first introduced two decades ago, and since then have been shown to explain robustly several distinctive features of the rheology in the strongly entangled regime, including extreme shear-thinning. We then turn to more complex rheological phenomena, particularly involving spatial heterogeneity, spontaneous oscillation, instability, and chaos. Recent understanding of these complex flows is based largely on grossly simplified models which capture in outline just a few pertinent microscopic features, such as coupling between stresses and other order parameters such as concentration. The role of `structural memory' (the dependence of structural parameters such as the micellar length distribution on the flow history) in explaining these highly nonlinear phenomena is addressed. Structural memory also plays an intriguing role in the little-understood shear-thickening regime, which occurs in a concentration regime close to but below the onset of strong entanglement, and which is marked by a shear-induced transformation from an inviscid to a gelatinous state.

Michael E. Cates; Suzanne M. Fielding

2007-02-02

287

Giant papillary conjunctivitis.  

PubMed Central

Giant papillary conjunctivitis is a syndrome found frequently as a complication of contact lenses. Many variables can affect the onset and severity of the presenting signs and symptoms. Rigid gas permeable contact lenses appear to result in less severe signs and symptoms, with a longer time before the development of giant papillary conjunctivitis. Nonionic, low-water-content soft contact lenses tend to produce less severe signs and symptoms than ionic, low-water-content soft contact lenses. Enzymatic treatment appears to lessen the severity of signs and symptoms. The association of an allergy appears to play a role in the onset of the severity of the signs and symptoms but does not appear to affect the final ability of the individual to wear contact lenses. Using multiple treatment options, such as changing the polymer to a glyceryl methyl methacrylate or a rigid lens, or utilizing a soft lens on a frequent-replacement basis, can result in a success rate of over 90%. In individuals who still have a return of symptoms, the use of topical mast cell stabilizers or a nonsteroidal anti-inflammatory drug as an adjunctive therapy offers the added possibility of keeping these patients in contact lenses. Images FIGURE 1 FIGURE 2 FIGURE 3 FIGURE 4 FIGURE 5 FIGURE 6 FIGURE 7 FIGURE 11 A FIGURE 11 B FIGURE 11 C FIGURE 11 D PMID:7886881

Donshik, P C

1994-01-01

288

Cavernous hemangioma of the third ventricle: a case report and review of the literature  

PubMed Central

Background Although cavernous hemangiomas (CHs) can be found anywhere in the central nervous system, CHs of the third ventricle have been reported in only 29 patients (including our case). In the current case report, we discuss the clinical characteristics and surgical outcome of CHs of the third ventricle. Case presentation A 64-year-old female was admitted to our emergency room with a sudden decreased level of consciousness. Brain imaging studies demonstrated a multi-lobulated hemorrhagic mass in the third ventricle. The lesion was removed via the transcallosal-interforniceal approach and pathologically diagnosed as CH. Postoperatively, the patient had a transient neurological deficit due to hypothalamic injury and recovered to the normal status at 2 months after the operation. In the review of 29 cases, the mean age of the patients was 40 years with a slight female preponderance (female/male, 17/12). The majority of the patients complained of a mass effect with signs of increased intracranial pressure; only one case was asymptomatic. Gross total resection was achieved in 81% of the cases. Around 80% of the patients were asymptomatic or improved from the initial symptoms. Mortality rate was 6.9% and the most common complication was hydrocephalus. Conclusions As demonstrated in the review of the previous reports, the outcome is favorable after surgical excision for CH of the third ventricle. Hence, surgical excision appears to be the treatment of choice for CH located in the third ventricle, which tends to grow rapidly resulting in a mass effect. PMID:25069472

2014-01-01

289

Subglottic hemangioma: a comparison of CO2 laser, Neodym-Yag laser, and tracheostomy.  

PubMed

For airway obstruction caused by subglottic hemangiomas, tracheostomy is still regarded by some as the only established therapy, despite numerous other therapeutic options. Resection with lasers was also reported, but subglottic scar formation may occur, and different laser types may have advantages over others. The charts of 46 consecutive patients over 26 years were reviewed. Until 1986, therapy involved systemic steroids or tracheostomy. Thereafter, a Neodym-Yag and after 1995 a CO2 laser was used. Mean initial stenosis was 61.0% in the first (n=15), 85.8% in the Neodym-Yag (n=14), and 86.7% in the CO2 period (n=17). Tracheostomy rates could be reduced from 76.9% to 46.9% with the Neodym-Yag and to 30.8% with the CO2 laser, and to 22.2% in children not intubated before referral. One tracheostomy obstruction resulted in severe neurological damage; granulomas required resection in 37.5%. Secondary subglottic stenosis was found in 15.4% with the Neodym-Yag, but not with the CO2 laser. With tracheostomy, 12.5% were symptom-free at age 2-3 years, vs. 25.0% in the Neodym-Yag and 41.6% in the CO2 laser period. Speech development was delayed in 75.0% with tracheostomy, and parental anxiety lessened in only 18.8% before the second birthday (68.8% without tracheostomy). Since the end of the retrospective analysis, we treated a further 21 patients (mean stenosis, 83.3%) with the CO2 laser, with only one tracheostomy (4.8%). Compared to steroids and tracheostomy, a significant reduction in morbidity and speech developmental delay, and an improved quality of life, were achieved with CO2 laser resection, and this approach was superior to the Neodym-Yag laser. PMID:15635618

Nicolai, Thomas; Fischer-Truestedt, Cordula; Reiter, Karl; Grantzow, Rainer

2005-03-01

290

Knockdown of VEGFR2 Inhibits Proliferation and Induces Apoptosis in Hemangioma-Derived Endothelial Cells  

PubMed Central

Angiogenesis is a process of development and growth of new capillary blood vessels from pre-existing vessels. Angiogenic growth factors play important roles in the development and maintenance of some malignancies, of which vascular endothelial growth factor (VEGF)/VEGFR2 interactions are involved in proliferation, migration, and survival of many cancer cells. The aim of this study was to investigate the function of VEGFR2 in human hemangiomas (HAs). Using immunohistochemistry assay, we examined the expression levels of VEGF, VEGFR2, Ki-67, glucose transporter-1 (Glut-1), phosphorylated protein kinase B (p-AKT) and p-ERK in different phases of human HAs. Positive expression of VEGF, VEGFR2, Ki-67, Glut-1, p-AKT and p-ERK was significantly increased in proliferating phase HAs, while decreased in involuting phase HAs (P=0.001; P=0.003). In contrast, cell apoptotic indexes were decreased in proliferating phase HAs, but increased in involuting phase HAs (P<0.01). Furthermore, we used small hairpin RNA (shRNA)-mediated VEGFR2 knockdown in primary HA-derived endothelial cells (HemECs) to understand the role of VEGF/VEGFR2 signaling. Knockdown of VEGFR2 by Lv-shVEGFR2 inhibited cell viability and induced apoptosis in primary HemECs companied with decreased expression of p-AKT, p-ERK, p-p38MAPK and Ki-67 and increased expression of caspase-3 (CAS-3); Overexpression of VEGFR2 promoted cell viability and blocked apoptosis in Lv-VEGFR2-transfected HemECs. Taken together, our findings demonstrate that, increased expression of VEGFR2 is involved in the development of primary HemECs possibly through regulation of the AKT and ERK pathways, suggesting that VEGFR2 may be a potential therapeutic target for HAs. PMID:24704994

Ou, J.M.; Yu, Z.Y.; Qiu, M.K.; Dai, Y.X.; Dong, Q.; Shen, J.; Dong, P.; Wang, X.F.; Liu, Y.B.; Quan, Z.W.; Fei, Z.W.

2014-01-01

291

Cancer incidence after radiotherapy for skin hemangioma: a retrospective cohort study in Sweden  

SciTech Connect

The cancer incidence was studied in 18,030 patients (33% males, 67% females) with skin hemangioma who were admitted to Radiumhemmet, Karolinska Hospital, Stockholm, Sweden, 1920-1959. Radium-226 sources were used in 12,821 patients, x-ray therapy was used in 2,515 patients, and no radiotherapy was given to 2,694 patients. Cancer incidence in the cohort was searched by record linkage with the Swedish Cancer Register for the period 1958-1982. The median age was 6 months for the treated patients and 8 months for the patients not receiving radiotherapy. In the group treated with radium-226 or orthovoltage x rays (greater than or equal to 100-kV peak), 224 cancers were observed (relative risk (RR) = 1.18; 95% confidence interval (CI) = 1.03-1.35). In patients given contact x rays, 10 cancers were observed (RR = 0.71; 95% CI = 0.34-1.30). In patients not treated with ionizing radiation, 34 cancers were observed (RR = 0.93; 95% CI = 0.64-1.29). In patients treated with radium-226 or orthovoltage x rays, an RR of 1.65 was observed for breast cancer (95% CI = 1.26-2.13) and an RR of 2.73 was found for soft tissue tumors (95% CI = 1.18-5.38). Patients with brain tumors, thyroid cancers, and bone tumors had received radiotherapy close to the tumor site more often than expected. For patients with breast cancer, no such difference was found. For cancers of the breast and thyroid, the RR was higher in patients given more than one treatment.

Fuerst, C.J.L.; Lundell, M.; Holm, L.E.; Silfverswaerd, C.

1988-11-02

292

Allometry indicates giant eyes of giant squid are not exceptional  

PubMed Central

Background The eyes of giant and colossal squid are among the largest eyes in the history of life. It was recently proposed that sperm whale predation is the main driver of eye size evolution in giant squid, on the basis of an optical model that suggested optimal performance in detecting large luminous visual targets such as whales in the deep sea. However, it is poorly understood how the eye size of giant and colossal squid compares to that of other aquatic organisms when scaling effects are considered. Results We performed a large-scale comparative study that included 87 squid species and 237 species of acanthomorph fish. While squid have larger eyes than most acanthomorphs, a comparison of relative eye size among squid suggests that giant and colossal squid do not have unusually large eyes. After revising constants used in a previous model we found that large eyes perform equally well in detecting point targets and large luminous targets in the deep sea. Conclusions The eyes of giant and colossal squid do not appear exceptionally large when allometric effects are considered. It is probable that the giant eyes of giant squid result from a phylogenetically conserved developmental pattern manifested in very large animals. Whatever the cause of large eyes, they appear to have several advantages for vision in the reduced light of the deep mesopelagic zone. PMID:23418818

2013-01-01

293

Topical propranolol cream in treatment of superficial infantile hemangiomas: a literature review and 4 years of clinical experience.  

PubMed

The clinical efficacy and safety profile of propranolol 1% cream in treatment of superficial infantile hemangiomas (IHs) were determined in a preliminary randomized group of eight infants. Five boys and three girls, 3 to 12 months old, with an IHs superficial capillary type on the forehead, posterior side of the neck, forearm, abdomen, or posterior side of the trunk were examined at our outpatient clinic between 2011 and 2014. Topical propranolol was applied twice daily for 10 months with clinical evaluation and photographic documentation performed every 1 to 2 months. Size, texture, and color changes were monitored. Therapeutic efficacy was evaluated using the Archauer system: Grade I (bad) reduction in size < 25%, Grade II (medium) reduction between 26% and 50%, Grade III (good) reduction between 51% and 75%, and Grade IV (excellent) reduction > 75%. The majority of hemangiomas treated, 62.5%, achieved Grade IV. A Grade III outcome was noticed in one patient with an IH (12.5%) and Grade II in 25% of patients with IHs on the abdomen. The treatment was well tolerated without side effects, which indicates that topical application of 1% propranolol is a safe, effective, and cheap therapeutic option for treating superficial IHs. PMID:25527040

Kova?evi?, Maja; Lukinovi? Škudar, Vesna; Mari?i?, Goran; Krnjevi?-Pezi?, Gordana; Stanimirovi?, Andrija

2014-01-01

294

Giant mediastinal mass: thymolipoma.  

PubMed

A 26-year-old man presented with shortness of breath on exertion that was gradually getting worse. His history revealed a mass in the left hemithorax that had been growing on follow-ups. Physical examination only showed that the respiratory sounds were fainter on the left. Thoracic computerized tomography was performed to elucidate the left hemithorax lesion seen on chest x-ray and a giant mass of lipid density extending from the anterior mediastinum to the diaphragm and filling almost the entire left hemithorax was observed. Total excision of the 25 × 21 × 8 cm mass weighing 1580 g was performed with a left thoracotomy. The histopathology investigation of the mass was reported as thymolipoma. The case was presented because it is a rare mediastinal mass. PMID:21606717

Alar, Timuçin; Ozçelik, Cemal; Kilnç, Nihal

2011-05-01

295

Giant Hedge-Hogs: Spikes on Giant Gravitons  

SciTech Connect

We consider giant gravitons on the maximally supersymmetric plane-wave background of type IIB string theory. Fixing the light-cone gauge, we work out the low energy effective light-cone Hamiltonian of the three-sphere giant graviton. At first order, this is a U(1) gauge theory on R x S{sup 3}. We place sources in this effective gauge theory. Although non-vanishing net electric charge configurations are disallowed by Gauss' law, electric dipoles can be formed. From the string theory point of view these dipoles can be understood as open strings piercing the three-sphere, generalizing the usual BIons to the giant gravitons, BIGGons. Our results can be used to give a two dimensional (worldsheet) description of giant gravitons, similar to Polchinski's description for the usual D-branes, in agreement with the discussions of hep-th/0204196.

Sadri, D

2004-01-28

296

Hepatitis A FAQs  

MedlinePLUS

... the feces, or stool, of an infected person. Statistics How common is Hepatitis A in the United ... South America, Mexico, and certain parts of Asia, Africa, and Eastern Europe. CDC’s Travelers’ Health site provides ...

297

Human hereditary hepatic porphyrias.  

PubMed

The human hereditary hepatic porphyrias are diseases due to marked deficiencies of enzymes in the heme biosynthetic pathway. Porphyrias can be classified as either hepatic or erythroid, depending on the major production site of porphyrins or their precursors. The pathogenesis of inherited hepatic porphyrias has now been defined at the molecular level. Some gene carriers are vulnerable to a range of exogenous and endogenous factors, which may trigger neuropsychiatric and/or cutaneous symptoms. Early diagnosis is of prime importance since it makes way for counselling. In this article we present an overview of recent advances on hepatic porphyrias: 5-aminolevulinic acid dehydratase deficiency porphyria, acute intermittent porphyria (AIP), porphyria cutanea tarda (PCT), hereditary coproporphyria (HC), and variegate porphyria (VP). PMID:12367763

Nordmann, Yves; Puy, Hervé

2002-11-01

298

[Hepatic encephalopathy: recent developments].  

PubMed

Hepatic encephalopathy is a neurological syndrome occurring in patients with liver failure or in those with a large porto-systemic shunt. In cirrhotic patients, the current classification comprises covert and overt encephalopathy. Diagnosis of covert encephalopathy requires sensitive tests. Lactulose and rifaximin are the two leading therapeutic options. Rifaximin is efficacious for maintaining remission from hepatic encephalopathy. Liver transplantation should be discussed in cirrhotic patients with encephalopathy. PMID:25277000

Deltenre, Pierre; Moradpour, Darius

2014-09-01

299

Benefits of Hepatitis A  

E-print Network

of Family Physicians, “Most children younger than 6 years do not show symptoms of hepatitis A. If illness does occur, the symptoms can last up to 2 months, but children do not usually have jaundice. We do know that infected children spread the hepatits A virus to the adults around them, and this can be serious. When adults are infected with hepatitis A, their symptoms can be much worse, sometimes requiring hospitalization.” The Hepatitis A Vaccine — A Safe and Effective Way to Protect Your Child According to Dr. Murphy, “Vaccinating all children is the most effective way to prevent them from spreading the infection to their family and others, and protects children as they grow older, when the illness can be more severe.” For the best protection, children and adults need two doses of the hepatitis A vaccine spaced 6 months apart. The first vaccine dose is recommended at age 12 months. The hepatitis A vaccine is very effective — nearly all of children and adults who receive both doses of the vaccine will be protected from hepatitis A. “Rates of hepatitis A in the United States have decreased by 80 % since we started vaccinating for this disease. This is a real testament to how effective this vaccine is, ” says Dr. Campos-Outcalt. The hepatitis A vaccine has an excellent safety record. This vaccine has never been known to cause any serious side effects. About 1 out of 6 children feels soreness after receiving the shot. About 1 out of 10 children may have a mild fever or poor appetite. If these problems occur, they usually last a day or two. However, vaccines like any medicine, could very rarely cause a severe allergic reaction.

Bonanni P; Boccalini S; Bechini A. Vaccination Against

300

All Kids Need Hepatitis B Shots  

MedlinePLUS

... immunize.org action coalition I All kids need hepatitis B shots! A series of shots can prevent ... got infected with hepatitis B virus What is hepatitis B? How do children and teens get hepatitis ...

301

Delta hepatitis in Malaysia.  

PubMed

Sera from one hundred and fifty nine Malaysian individuals were screened for the prevalence of delta markers. These included 15 HBsAg positive homosexuals, 16 acute hepatitis B cases, 9 chronic hepatitis B patients, 13 healthy HBsAg carriers and 106 intravenous (i.v.) drug abusers, of whom 27 were positive for HBsAg only and the rest were anti-HBc IgG positive but HBsAg negative. The prevalence of delta markers in the homosexuals was found to be 6.7%, in the HBsAg positive drug abusers 17.8%, in acute hepatitis B cases 12.5%. No evidence of delta infection was detected in healthy HBsAg carriers, chronic hepatitis B cases and HBsAg negative i.v. drug abusers. With reference to i.v. drug abusers, the prevalence of delta markers was higher in Malays (23%) than in Chinese (7%) although the latter had a higher HBsAg carrier rate. Although the HBsAg carrier rate in the homosexuals was high, their delta prevalence rate was low as compared to drug abusers. In Malaysia, as in other non-endemic regions, hepatitis delta virus transmission appeared to occur mainly via the parenteral and sexual routes. This is the first time in Malaysia that a reservoir of delta infection has been demonstrated in certain groups of the population at high risk for hepatitis B. PMID:3787309

Sinniah, M; Dimitrakakis, M; Tan, D S

1986-06-01

302

A case of multiple macronodular hepatic tuberculosis difficult to differentiate from hepatocellular carcinoma with intrahepatic metastasis: CT-guided fine needle aspiration biopsy confirmed the diagnosis  

PubMed Central

Multiple macronodular hepatic tuberculosis is difficult to be differentiated from hepatocellular carcinoma with intrahepatic metastasis in clinical practice, especially when hepatitis B with or without liver cirrhosis coexists with it. Herein, we report a 30-year-old man with a 10-year history of hepatitis B and a family medical history of hepatocellular carcinoma related with hepatitis B that was finally diagnosed as multiple macronodular hepatic tuberculosis. Abdominal B-mode ultrasonography (US) and plain computed tomography (CT) revealed multiple unequal-sized nodules in the liver. CT-guided fine needle aspiration biopsy (FNAB) of the liver demonstrated a caseating granuloma with lymphocytes, multinucleate giant cells and epithelioid cells compatible with the diagnosis of tuberculosis and no hepatoma cells were detected. Thus, the diagnosis of hepatic tuberculosis was confirmed and hepatocellular carcinoma with intrahepatic metastasis was excluded. PMID:25550879

Zhang, Lei; Yang, Nai-Bin; Ni, Shun-Lan; Zhang, Sai-Nan; Shen, Chen-Bo; Lu, Ming-Qin

2014-01-01

303

Giant magnetoresistance in narrow stripes  

Microsoft Academic Search

A simple model for giant magnetoresistance in thin-film magnetic sandwiches was developed. Giant magnetoresistance (GMR) and anisotropic magnetoresistance (AMR) were measured using 1.5-?m to 10-?m-wide×70-?m-long test structures etched from magnetic sandwiches with two magnetic films and a thin nonmagnetic conducting interlayer. Magnetic fields were applied to the sandwiches by passing current through the stripes and by applying external fields. The

J. M. Daughton; P. A. Bade; M. L. Jenson; M. M. M. Rahmati

1992-01-01

304

The Giant Magnetocaloric Effect  

NASA Astrophysics Data System (ADS)

Since the discovery of the magnetocaloric effect in pure iron by E.Warburg in 1881, it has been measured experimentally on many magnetic metals and compounds. The majority of the materials studied order magnetically undergoing a second order phase transformation. The magnetocaloric effect, typically peaking near the Curie or the Néel temperature, generally ranges from 0.5 to 2 K (in terms of adiabatic temperature change) or at 1 to 4 J/kg K (in terms of isothermal magnetic entropy change) per 1 T magnetic field change. The giant magnetocaloric effect recently discovered in Gd_5(Si_xGe_1-x)4 alloys, where x <= 0.5, is associated with a first order magnetic phase transition and it reaches values of 3 to 4 K and 6 to 10 J/kg K per 1 T field change, respectively. The refrigerant capacity, which is the measure of how much heat can be transferred from a cold to a hot reservoir in one ideal thermodynamic cycle, is larger than that of the best second order phase transition materials by 25 to 100%. When the Gd_5(Si_xGe_1-x)4 alloys are compared with other known materials, which show first order magnetic phase transition, such as Dy, Ho, Er, HoCo_2, NdMn_2Si_2, Fe_0.49Rh_0.51, and (Hf_0.83Ta_0.17)Fe_2+x, only Fe_0.49Rh_0.51 has comparable magnetocaloric properties. However, the first order magnetic phase transition in Fe_0.49Rh_0.51 is irreversible, and the magnetocaloric effect disappears after one magnetizing/demagnetizing cycle. A study of the crystal structure, thermodynamics, and magnetism of the Gd_5(Si_xGe_1-x)4 alloys, where 0 <= x <= 1 allowed us to obtain a qualitative understanding of the basic relations between the composition, the crystal structure, and the change in thermodynamics and magnetocaloric properties, which occur in the Gd_5(Si_xGe_1-x)4 system, and which brings about the giant magnetocaloric effect when x <= 0.5.

Pecharsky, Vitalij K.

1998-03-01

305

Calpain and lipopolysaccharide mediated hepatitis  

E-print Network

-mediated hepatitis model to investigate the mechanisms of hepatic neutrophil infiltration following LPS administration was developed by repeat intravenous injection of LPS at a dose of 10 mg/kg to rats. Blood was collected for hematologic and biochemical analysis...

Rose, Robert Edward

2009-06-02

306

Hepatitis B: Information for Parents  

MedlinePLUS

... is a contagious liver disease caused by the hepatitis B virus. When a person is first infected with the ... 6 months after someone is infected with the hepatitis B virus. This infection can range from a very mild ...

307

Rotation of Giant Stars  

E-print Network

The internal rotation of post-main sequence stars is investigated, in response to the convective pumping of angular momentum toward the stellar core, combined with a tight magnetic coupling between core and envelope. The spin evolution is calculated using model stars of initial mass 1, 1.5 and $5\\,M_\\odot$, taking into account mass loss on the giant branches and the partitioning of angular momentum between the outer and inner envelope. We also include the deposition of orbital angular momentum from a sub-stellar companion, as influenced by tidal drag as well as the excitation of orbital eccentricity by a fluctuating gravitational quadrupole moment. A range of angular velocity profiles $\\Omega(r)$ is considered in the deep convective envelope, ranging from solid rotation to constant specific angular momentum. We focus on the backreaction of the Coriolis force on the inward pumping of angular momentum, and the threshold for dynamo action in the inner envelope. Quantitative agreement with measurements of core ro...

Kissin, Yevgeni

2015-01-01

308

Hepatic cysticercosis: a rare entity.  

PubMed

Hepatic cysticercosis is a very rare entity; only four cases have been reported to date. High-resolution ultrasonography of the abdomen is the initial and most reliable modality for evaluation of hepatic cysticercosis. Medical therapy is the mainstay of treatment. We report a case of hepatic cysticercosis in a 28-year-old male who presented with right upper quadrant pain, fever, and jaundice. The article also describes the imaging patterns of hepatic cysticercosis based on different stages of evolution. PMID:24806312

Chaudhary, Vikas; Bano, Shahina; Kumar, Praveen; Narula, Mahender Kaur; Anand, Rama

2014-12-01

309

Acute hepatic failure in children.  

PubMed Central

Many diseases may present as acute hepatic failure in the pediatric age group, including viral hepatitis A and B, adverse drug reactions, both toxic and "hepatitic," and inherited metabolic disorders such as tyrosinemia, alpha 1 antitrypsin deficiency, and Wilson's disease. Management is primarily supportive, with care taken to anticipate the known complications of hepatic failure. Few "curative" therapies are known, although attempts at stimulating hepatic regeneration may be helpful. Images FIG. 1 FIG. 3 FIG. 4 PMID:6433587

Riely, C. A.

1984-01-01

310

Formation of the giant planets  

NASA Technical Reports Server (NTRS)

The observed properties of giant planets, models of their evolution and observations of protoplanetary disks provide constraints on the formation of gas giant planets. The four largest planets in our Solar System contain considerable quantities of hydrogen and helium, which could not have condensed into solid planetesimals within the protoplanetary disk. All three (transiting) extrasolar giant planets with well determined masses and radii also must contain substantial amounts of these light gases. Jupiter and Saturn are mostly hydrogen and helium, but have larger abundances of heavier elements than does the Sun. Neptune and Uranus are primarily composed of heavier elements. HD 149026 b, which is slightly more massive than is Saturn, appears to have comparable quantities of light gases and heavy elements. HD 209458 b and TrES-1 are primarily hydrogen and helium, but may contain supersolar abundances of heavy elements. Spacecraft flybys and observations of satellite orbits provide estimates of the gravitational moments of the giant planets in our Solar System, which in turn provide information on the internal distribution of matter within Jupiter, Saturn, Uranus and Neptune. Atmospheric thermal structure and heat flow measurements constrain the interior temperatures of planets. Internal processes may cause giant planets to become more compositionally differentiated or alternatively more homogeneous; high-pressure laboratory .experiments provide data useful for modeling these processes. The preponderance of evidence supports the core nucleated gas accretion model. According to this model, giant planets begin their growth by the accumulation of small solid bodies, as do terrestrial planets. However, unlike terrestrial planets, the growing giant planet cores become massive enough that they are able to accumulate substantial amounts of gas before the protoplanetary disk dissipates. The primary questions regarding the core nucleated growth model is under what conditions planets with small cores/total heavy element abundances can accrete gaseous envelopes within the lifetimes of gaseous protoplanetary disks.

Lissauer, Jack J.

2006-01-01

311

[Hepatitis E as zoonosis].  

PubMed

The hepatitis E virus (HEV) the causative agent of hepatitis E, is a non-enveloped RNA virus. HEV is transmitted through oral consumption of contaminated food and water According to the currently knowledge now be considered as zoonosis. The main reservoir of HEV are pigs, boars and deer. For the first time HEV was isolated from animals (pigs) in 1997 in the U.S. Genetic analysis of strains isolated from pigs showed high similarity to strains HEV isolated from humans. This was the first evidence showing that HEV is a zoonosis. Further studies have shown that occupational groups e.g. veterinarians, swine breeders with close contact to pigs have an increased risk for HEV infections. The additional evidence supported the zoonotic potential of HEV were reports of acute hepatitis E after the consumption of undercooked meat from deer and wild boar. Infection of HEV in the domestic pig and wild boar population in Europe is widespread. PMID:21735829

Baumann-Popczyk, Anna

2011-01-01

312

Giants of the Animal Kingdom  

NSDL National Science Digital Library

The following Web sites offer a quick tour of some of the planet's outsized inhabitants, from the relatively large (e.g. giant cave cockroach) to the just plain enormous (e.g. blue whale). The first Web site (1) is an Animal Planet Feature where visitors can meet giants of the past -- such as the giant komodo dragon and the giant sloth, and some of their smaller, modern-day cousins. The site contains lots of cool graphics, including 3-D rotatable images. The next stop is a commercial Web site advertising photography expeditions let by Amos Nachoum, a professional marine and wildlife photographer. All of the expeditions listed in the left-hand column include photo galleries where visitors can view terrific photos of Argentinian orcas, polar bears, blue whales, and more (2). The following Web site (3) is the online companion to "Toothwalkers: Giants of the Arctic Ice," a PBS Nature documentary about the giant saber-toothed Arctic walrus. Visitors will find special Web features, a video clip, and links to more information on the film and its gargantuan stars. The Discovery Channel introduces the elusive giant squid in this multimedia Web feature (4). Viewers will find loads of information on this amazing creature's natural history, literary history, and much more. The site also includes a trip on a virtual submersible, where you can learn more about life 2,000 feet below sea level. The next Web site is privately hosted by Chris "Capy" Head, and provides a great overview of the world's largest rodent, the undeniably adorable capybara (5). Visitors will find basic background information, links, a photo gallery, and more. Steve Bullington presents the giant cave roach in this privately-hosted Web site (6) as part of Bullington's Pet Arthropod Page. The site includes photos and detailed background information for this outsized roach (the world's largest species). The ostrich, which can claim the title of largest living bird (with the largest eggs, as well), gets its own page in this Web feature from PBS's Nature. Readers will find a quick overview of ostrich characteristics and natural history (7). And of course, what discussion of giant animals would be complete without mentioning the blue whale? In this Web site (8), the American Cetacean Society provides an informative fact sheet on "the largest mammal, possibly the largest animal, to ever inhabit the earth.

313

Giant polarization in high polymers  

NASA Astrophysics Data System (ADS)

In the course of studying the properties of highly conjugated polymers we found that long range orbital delocalization conferred unexpected properties. The presence of giant electronic orbitals made these materials electroactive yet very stable. A new mode of electronic polarizability resulted, a giant nomadic polarization, making these organic polymers among the most polarizable materials ever encountered. In addition, yet other attributes could be found, such as remanent magnetization, or metallic conductivity, or unusual pressure sensitivity. The giant orbital concept opens up new vistas of materials properties. We note that one can tailor giant orbital polymers to produce pure and highly stable super-dielectrics with high dielectric constants, from 6 to 100,000. Such materials will be useful in the electric power control, as in large motor starting capacitors and in power factor correction. They will doubtless also be useful in low visibility coatings, in obscuration, in EMP shielding, in microcircuitry, in transducers, and in parametric circuits. It remains to be proven if this new molecular mode, nomadic polarization, proves superior in energy storage and loss to that of the conventional “dipole orientation” mode. Preliminary results indicate an advantage for the new giant orbital materials.

Pohl, Herbert A.

1986-07-01

314

Alcoholic hepatitis and concomitant hepatitis C virus infection  

PubMed Central

Hepatitis C virus (HCV) infection and alcohol abuse are two most important causes of chronic liver disease in the United States. Alcoholic hepatitis is a unique clinical syndrome among patients with chronic and active alcohol abuse with a potential for high short-term mortality. About 20% of patients presenting with alcoholic hepatitis have concomitant HCV infection. Mortality from alcoholic hepatitis is increased in the presence of concomitant hepatitis C due to synergistic interaction between HCV and alcohol in causing hepatocellular damage. Large prospective randomized studies are needed to develop guidelines on the use of corticosteroids among patients with alcoholic hepatitis and concomitant HCV infection. The impact of antiviral therapy on mortality and outcome in the setting of alcoholic hepatitis remains a novel area for future research. PMID:25232227

Shoreibah, Mohamed; Anand, Bhupinderjit S; Singal, Ashwani K

2014-01-01

315

Giant sacral schwannomas.  

PubMed

Sacral schwannomas are very rare tumors. There are merely around 50 cases reported in the literature most of which are case presentations. In this study we present a 13-case series, which is one of the most extensive series in the literature. Thirteen giant sacral schwannoma cases operated at Ege University, Faculty of Medicine, Neurosurgery Department between 1995 and 2010 are investigated retrospectively. All patients were assessed with direct radiography, computerized tomography (CT) and magnetic resonance imaging (MRI). The patients were operated, after the diagnosis through biopsy patients with Sridhar Type V classification are included in the study. Five patients were male, eight were female and the average age was 37.1 (ranging between 14 and 55). All the patients were suffering from back and leg pain at the time of consultation. Four patients had sphincter problems and three had weakness in the leg. After the biopsy and histological analysis, intralesionary resections were performed. Five patients went through both anterior and posterior interventions, six patients had only posterior and two had just anterior intervention. One patient had iliac vein injury during the anterior surgery. This patient was reoperated for embolectomy and vein graft because of thrombosis. Average follow-up period was 8.1 years (1-15 years). All patients were assessed with MR annually. A small residual tumor was detected in two patients, however they were not reoperated. Although sacral schwannomas are rare tumors, the diagnosis is not so difficult with CT and MRI. In this study, we suggest biopsy for predetermination of the nature of the tumor as it affects the treatment choice and the method of operation. Surgically, a simple intralesionary excision is an appropriate choice. PMID:22806341

Ça?l?, Sedat; I??k, Hasan Serdar; Y?ld?r?m, Umut; Ak?ntürk, Nevhis; Zileli, Mehmet

2012-10-01

316

Giant Magellan Telescope: overview  

NASA Astrophysics Data System (ADS)

The Giant Magellan Telescope (GMT) is a 25-meter optical/infrared extremely large telescope that is being built by an international consortium of universities and research institutions. It will be located at the Las Campanas Observatory, Chile. The GMT primary mirror consists of seven 8.4-m borosilicate honeycomb mirror segments made at the Steward Observatory Mirror Lab (SOML). Six identical off-axis segments and one on-axis segment are arranged on a single nearly-paraboloidal parent surface having an overall focal ratio of f/0.7. The fabrication, testing and verification procedures required to produce the closely-matched off-axis mirror segments were developed during the production of the first mirror. Production of the second and third off-axis segments is underway. GMT incorporates a seven-segment Gregorian adaptive secondary to implement three modes of adaptive-optics operation: natural-guide star AO, laser-tomography AO, and ground-layer AO. A wide-field corrector/ADC is available for use in seeing-limited mode over a 20-arcmin diameter field of view. Up to seven instruments can be mounted simultaneously on the telescope in a large Gregorian Instrument Rotator. Conceptual design studies were completed for six AO and seeing-limited instruments, plus a multi-object fiber feed, and a roadmap for phased deployment of the GMT instrument suite is being developed. The partner institutions have made firm commitments for approximately 45% of the funds required to build the telescope. Project Office efforts are currently focused on advancing the telescope and enclosure design in preparation for subsystem- and system-level preliminary design reviews which are scheduled to be completed in the first half of 2013.

Johns, Matt; McCarthy, Patrick; Raybould, Keith; Bouchez, Antonin; Farahani, Arash; Filgueira, Jose; Jacoby, George; Shectman, Steve; Sheehan, Michael

2012-09-01

317

CMB lensing and giant rings  

NASA Astrophysics Data System (ADS)

We study the CMB lensing signature of a pre-inationary particle (PIP), assuming it is responsible for the giant rings anomaly that was found recently in the WMAP data. Simulating Planck-like data we find that generically the CMB lensing signal to noise ratio associated with such a PIP is quite small and it would be difficult to cross correlate the temperature giant rings with the CMB lensing signal. However, if the pre-inationary particle is also responsible for the bulk flow measured from the local large scale structure, which happens to point roughly at the same direction as the giant rings, then the CMB lensing signal to noise ratio is fairly significant.

Rathaus, Ben; Itzhaki, Nissan

2012-05-01

318

Giant myoma and erythrocytosis syndrome.  

PubMed

The objective of this study is to discuss the myomatous erythrocytosis syndrome in a patient with a giant subserous uterine myoma. She presented with plethora and an abdominal mass. After venesection of 4 units of blood, the preoperative haematocrit value of 53.3% and haemoglobin value of 17.5 g/dL had decreased to 48.6% and 16.8 g/dL levels, respectively. After the operative extraction of the giant subserous myoma with attached uterus weighing 14.2 kg, the haematocrit and the haemoglobin values had regressed to 40.3% and 14.3 g/dL levels, respectively. The findings indicated that the giant subserous myoma was the cause of the myomatous erythrocytosis syndrome in this patient. PMID:10554963

Ozsaran, A A; Itil, I M; Terek, C; Kazandi, M; Dikmen, Y

1999-08-01

319

Giant lobelias exemplify convergent evolution  

PubMed Central

Giant lobeliads on tropical mountains in East Africa and Hawaii have highly unusual, giant-rosette growth forms that appear to be convergent on each other and on those of several independently evolved groups of Asteraceae and other families. A recent phylogenetic analysis by Antonelli, based on sequencing the widest selection of lobeliads to date, raises doubts about this paradigmatic example of convergent evolution. Here I address the kinds of evidence needed to test for convergent evolution and argue that the analysis by Antonelli fails on four points. Antonelli's analysis makes several important contributions to our understanding of lobeliad evolution and geographic spread, but his claim regarding convergence appears to be invalid. Giant lobeliads in Hawaii and Africa represent paradigmatic examples of convergent evolution. PMID:20074322

2010-01-01

320

Annular elastolytic giant cell granuloma.  

PubMed

A 49-year-old woman had large annular lesions with raised erythematous borders and atrophic, hypopigmented central regions on her neck, trunk, and proximal upper extremities. Examination of a biopsy specimen demonstrated a granulomatous infiltrate in the upper dermis that surrounded areas lacking elastic fibers; elastic fibers were present within the multinucleated giant cells. The clinical presentation and pathologic findings were consistent with a diagnosis of annular elastolytic giant cell granuloma (AEGCG). The clinical description and pathologic differential diagnosis of AEGCG are reviewed. PMID:9798106

Tock, C L; Cohen, P R

1998-10-01

321

Giant lumbosacral schwannoma in a child  

PubMed Central

Small spinal intradural extramedullary schwannoma are a common occurrence in the middle aged. However, giant schwannoma in pediatric age group is rare. We report one such case of giant extradural lumbosacral schwannoma in an 8-year-old child. Clinical features, histopathology and management of giant schwannoma is discussed and the present literature reviewed. PMID:23248693

Kataria, Rashim; Kurmi, Dhruba Jyoti; Mehta, Jayanti; Sinha, Virendra Deo

2012-01-01

322

Giant right atrial thrombi treated with thrombolysis  

PubMed Central

The present report describes giant atrial thrombi that were treated with thrombolysis in a community hospital. Two patients with giant atrial thrombi whose treatment involved complications are presented. Both patients developed cardiogenic shock and were treated unsuccessfully with thrombolysis. Because thrombolysis of giant thrombi may be ineffective, patients in this situation may require surgery. PMID:18401474

Ruiz-Bailén, Manuel; López-Caler, Carmen; Castillo-Rivera, Ana; Rucabado-Aguilar, Luis; Cuadra, José Ángel Ramos; Toral, Juan Lara; Cabezas, Cristobal Lozano; Guerrero, Juan Carlos Fernández

2008-01-01

323

P. Roingeard -Journal of Viral Hepatitis 2013 ; 20, 77-84. Page 1 Hepatitis C virus diversity and hepatic steatosis  

E-print Network

P. Roingeard - Journal of Viral Hepatitis 2013 ; 20, 77-84. Page 1 REVIEW Hepatitis C virus diversity and hepatic steatosis P. Roingeard. INSERM U966, Université François Rabelais & CHRU de Tours, 10, published in "Journal of Viral Hepatitis 2013;20(2):77-84" #12;P. Roingeard - Journal of Viral Hepatitis

Paris-Sud XI, Université de

324

NK cells in chronic hepatitis C and hepatitis B Fine Characterization of Intra-hepatic NK cells Expressing  

E-print Network

1 NK cells in chronic hepatitis C and hepatitis B Fine Characterization of Intra-hepatic NK cells Expressing Natural Killer Receptors in Chronic Hepatitis B and C Paula Bonorino1,2* , Muhammad Ramzan 1. The proportions of intra-hepatic NK cells expressing either NKG2A, and/or CD158a,h, CD158b,j differed

Boyer, Edmond

325

4 Acute hepatitis C  

Microsoft Academic Search

Acute hepatitis C is usually a sub-clinical disease, thus it is not included in the differential diagnosis of patients with acute disease. Making the diagnosis is also diffi cult because the virus antibodies appear at later stages and many even be negative even if the patient has symptoms; at this point the diagnosis of the disease could be made with

Jay H. Hoofnagle; JUAN CARLOS RESTREPO; John Jaime; Juan Carlos; Restrepo Gutiérrez; Gutiérrez Calle

2000-01-01

326

Hepatitis C virus  

Microsoft Academic Search

Summary HepCV is the major cause of NANB PT hepatitis and is also implicated as the cause in a large proportion of sporadic cases of NANBH. Chronic infection with HepCV has also been linked to the development of hepatocellular carcinoma. Chimpanzees and marmosets are the only animals found to be experimentally infectable and the virus has not been propagated in

P. G. W. Plagemann

1991-01-01

327

Management of Hepatic Encephalopathy  

PubMed Central

Hepatic encephalopathy (HE), the neuropsychiatric presentation of liver disease, is associated with high morbidity and mortality. Reduction of plasma ammonia remains the central therapeutic strategy, but there is a need for newer novel therapies. We discuss current evidence supporting the use of interventions for both the general management of chronic HE and that necessary for more acute and advanced disease. PMID:21994873

Wright, G.; Chattree, A.; Jalan, R.

2011-01-01

328

Infected solitary hepatic cyst.  

PubMed

An unusual case involving an infected hepatic cyst in which the correct diagnosis was made without operation is reported. A 93-year-old woman presented with acute onset of right upper quadrant abdominal pain, mild left lower quadrant abdominal pain, diarrhea, and fever. On admission, computed tomography revealed a 15 cm solitary hepatic cyst in the anterior-superior segment of the liver with a thickened wall that enhanced with contrast media. Ultrasonography demonstrated a 15 cm anechoic lesion with a hypoechoic area in the dependent portion of the cyst and a thickened wall. The serum concentration of C-reactive protein was 24.3 mg/dL, and the white blood cell count was 13,800/microL. A diagnosis of infected hepatic cyst was suspected, and percutaneous transhepatic drainage of the cyst was performed. Milky yellow fluid was obtained and the patient's right upper quadrant abdominal pain resolved after drainage. Klebsiella pneumoniae was cultured from the drainage fluid. The patient was discharged 20 days after drainage. Infection has not recurred and the hepatic cyst has not enlarged after 18 months. PMID:14685292

Yoshida, Hiroshi; Tajiri, Takashi; Mamada, Yasuhiro; Taniai, Nobuhiko; Kawano, Youichi; Mizuguchi, Yoshiaki; Shimizu, Tetsuya; Takahashi, Tsubasa; Uchida, Eiji; Watanabe, Manabu; Uchida, Eiichi

2003-12-01

329

Viral hepatitis B  

Microsoft Academic Search

More than 170 million people worldwide are chronically infected with the hepatitis C virus (HCV), which is responsible for more than 100 000 cases of liver cancer per year, with similar numbers of digestive haemorrhage and ascites episodes. Major breakthroughs have been made in diagnosis and treatment, and advances in molecular biology mean that the replicative state of the virus

Ching Lung Lai; Vlad Ratziu; Man-Fung Yuen; Thierry Poynard

2003-01-01

330

Hepatitis B Foundation  

MedlinePLUS

... important for anybody who is into rolex replica yoga or Pilates. Tracking down the best yoga mat rolex replica bag can occasionally be arduous ... with Hepatitis B Adults and HBV Pregnant Women Children and HBV Journal Articles Personal Stories Treatment Options ...

331

The hepatitis B virus  

Microsoft Academic Search

DNA recombinant technology has radically changed hepatitis B virus (HBV) virology. The genetic organization, transcription and replication of the virus are basically understood, structures of integrated HBV sequences in hepatocellular carcinoma have been characterized, and new vaccines produced by recombinant DNA technique are being developed.

Pierre Tiollais; Christine Pourcel; Anne Dejean

1985-01-01

332

[First case of hepatitis B virus genotype H infection in Turkey].  

PubMed

Clinical studies reported from Turkey indicate that hepatitis B virus (HBV) genotype D is more prevalent than other genotypes. Epidemiological and clinical information on genotype H infection is currently limited. Genotype H infection is most likely due to its regional (Central and South America) prevalence throughout the world. The aim of this report is to present the first HBV genotype H infection in a chronic hepatitis B patient in Turkey. Laboratory findings of a 42 years old male patient admitted to our hospital revealed HBsAg (+), anti-HBs (-), HBeAg (-), anti-HBe (+), anti-HBc IgM (-), anti-HBc IgG (+), anti-HAV IgG (+), HBV-DNA: 5.689.776 IU/ml and high liver enzymes (ALT: 223 U/L, AST: 121 U/L). History of the patient indicated no risk factor (intravenous drug use, blood transfusion, suspicious sexual contact) related to HBV transmission. Since liver ultrasonography showed multiple hemangiomas, biopsy was performed and histologic activity index was found as 6/18 and fibrosis as 2/6, according to modified Knodell score system. HBV DNA isolated from the serum sample of the patient was amplified by polymerase chain reaction and polymerase gene segment of HBV was directly sequenced. UPGMA method was used for phylogenetic analysis, and the genotype of the virus was identified accordingly. The nucleotide sequence was compared to those from the international DNA data bank (GenBank). The genotyping of the patient revealed that the isolated HBV was genotype H. Treatment with tenofovir disoproxil fumarate was initiated and the patient responded to the treatment. This finding suggested that other HBV genotypes, except the predominant genotype D may also be in circulation in Turkey. In conclusion, detection of epidemiologic and molecular characteristics of HBV genotype H which is related to chronic hepatitis, seems to be necessary in order to better understand its circulation and progression around the world. PMID:23971934

Ural, Onur; Sayan, Murat; Akhan, S?la; Sümer, Sua; Sim?ek, Funda

2013-07-01

333

Role of endoscopic CO2 laser surgery in the treatment of congenital infantile subglottic hemangioma. Experience in the Department of Otolaryngology, "Sick Children Hospital", Toronto, Canada.  

PubMed

Subglottic hemangioma is a rare, histologically benign congenital neoplasm. The natural history is characterized by progressive obstruction of the airways during the proliferative stage, followed by gradual regression of the obstructive symptomatology in the involutional phase. After an asymptomatic neonatal period, the infant presents a characteristic biphasic stridor as the lesion progressively obstructs the subglottic space. In 80-90% of cases, these symptoms appear in the first six months of life. The involutional process generally begins at 12 months of age and continues until the subglottic hemangioma regresses completely. Due to high incidence of mortality in untreated cases, therapy should be undertaken immediately. Aim of therapy is to restore normal respiration, attempting to preserve the child's voice and alter the quality of life both of the infant and the family as little as possible. A retrospective study was carried out on all cases of infantile subglottic hemangioma treated in the Department of Otolaryngology, "Sick Children Hospital", Toronto, between 1980 and 2000. The therapeutic strategy adopted until breathing returned to normal comprised repeated endoscopic CO2 laser treatment of the lesion and perioperative administration of oral cortisone (1 mg/kg/day dexamethazone, subdivided in 3 doses) for 24-48 hours. CO2 laser was used each time the patient presented progressive worsening of obstructive respiratory symptoms. The interval between two laser treatments was > or = 6 weeks. Repeated endoscopic laser treatment, combined with other therapeutic modalities, enabled tracheotomy to be avoided in all but 4 (7.2%) cases. PMID:14677310

Re, M; Forte, V; Berardi, C; Mallardi, V

2003-06-01

334

Benefits of skin biopsy of senile hemangioma in intravascular large B-cell lymphoma: A case report and review of the literature.  

PubMed

Intravascular large B-cell lymphoma (IVLBCL) is a rare subtype of B-cell lymphoma characterized by selective growth of clonal B-cells in the lumen of the small vessels of various organs including the liver, spleen, lungs, skin, brain, and kidney. An 86-year-old male presented with weight loss, fever and night sweats (known as B symptoms). Blood examination revealed pancytopenia, high lactate dehydrogenase and high soluble interleukin-2 receptor, suggesting hematopoietic malignancy. However, there were no abnormal hematopoietic cells in the peripheral blood. No lymph node swelling was identified on examination by whole-body computed tomography scan. Therefore, IVLBCL was suspected, and random skin biopsies and a skin biopsy from a senile hemangioma were carried out. A small number of large atypical lymphoid cells resided in the small blood vessels in the deep dermis and subcutaneous tissue of the random skin biopsies, and numerous atypical lymphoid cells were identified in the small vessels of the senile hemangioma. These results suggest the usefulness of skin biopsy from senile hemangiomas in the diagnosis of IVLBCL. PMID:24932279

Adachi, Yasushi; Kosami, Koki; Mizuta, Noritoshi; Ito, Mitsuhiro; Matsuoka, Yuki; Kanata, Mami; Akiyama, Hajime; Murao, Tomoko; Li, Ming; Ieki, Ryuji; Ikehara, Susumu

2014-06-01

335

Durchbruch bei der Therapie der Hepatitis C  

E-print Network

Durchbruch bei der Therapie der Hepatitis C: Segen für die Patienten ­ Albtraum für die Behandler -Virushepatitis Oktober 2012 #12;H. Wedemeyer -Virushepatitis Oktober 2012 Hepatitisviren Hepatitis A Feinstone 1973 RNA Hepatitis B Blumberg 1965 DNA Hepatitis C Houghton 1988 RNA Hepatitis D Rizzetto 1977 RNA

Manstein, Dietmar J.

336

VACCINE INFORMATION STATEMENT Hepatitis B Vaccine  

E-print Network

VACCINE INFORMATION STATEMENT Hepatitis B Vaccine What You Need to Know Many Vaccine Information://www.immunize.org/vis What is hepatitis B? Hepatitis B is a serious infection that affects the liver. It is caused by the hepatitis B virus. · In 2009, about 38,000 people became infected with hepatitis B. · Each year about 2

Leistikow, Bruce N.

337

VACCINE INFORMATION STATEMENT Hepatitis B Vaccine  

E-print Network

VACCINE INFORMATION STATEMENT Hepatitis B Vaccine What You Need to Know Many.Visitehttp://www.immunize.org/vis 1 What is hepatitis B? Hepatitis B is a serious infection that affects the liver. It is caused by the hepatitis B virus. · In2009,about38,000peoplebecameinfectedwith hepatitis B. · Eachyearabout2,000to4

Tennessee, University of

338

Giant resonances in O-16  

E-print Network

Giant resonances in O-16 have been studied with inelastic scattering of 240 MeV alpha particles at small angles, Isoscalar E0, E1, and E2 strength corresponding to 48 +/- 10%, 32 +/- 7%, and 53 +/- 10%, of the respective energy-weighted sum rule...

Lui, YW; Clark, HL; Youngblood, David H.

2001-01-01

339

Giant Serpentine Aneurysms: Multidisciplinary Management  

PubMed Central

Summary Sixty-five cases of intracranial giant serpentine aneurysms (GS?s), including 61 cases reported in the literature and four additional cases presented in this study were reviewed. The clinical presentation, possible causes, natural history, and especially management of GSAs are discussed with emphasis on the need for aggressive intervention and multidisciplinary management. PMID:20667180

Anshun, W.; Feng, L.; Daming, W.

2000-01-01

340

Giant magnetoresistance in electrodeposited films  

Microsoft Academic Search

Electrodeposition is one of the simpler and cheaper processes available for the fabrication of thin metal films. Recent developments have made it possible to electrodeposit a wide range of nanostructured materials, including many that exhibit giant magnetoresistance (GMR). We review progress in the growth and characterization of such films, starting with electrodeposited ferromagnetic metal\\/non-magnetic metal superlattices in which the individual

W. Schwarzacher; D. S. Lashmore

1996-01-01

341

Giant Lipoma: A Case Report  

PubMed Central

A lipoma is a fatty tissue tumor presenting as a painless slowly growing mass that can affect any part of the body rich in adipose tissue. Lipomas can be present in the thigh, shoulder, trunk, etc, although they are usually small. We are reporting a 65-year-old man with a giant lipoma involving his left buttock and lumbar region. PMID:23610489

Zaroo, Mohammad Inam; Bashir, Sheikh Adil; Mohsin, Mir; Baba, Peerzada Umar Farooq; Farooq, Syed Suraiya Arjumand; Zargar, Haroon Rashid

2011-01-01

342

Hepatitis G virus infection in fulminant hepatic failure  

Microsoft Academic Search

Background—RNA sequences of the recently identified hepatitis GB virus C (HGBV-C), also named hepatitis G virus (HGV), have been detected in patients with idiopathic fulminant hepatic failure (FHF) but the role of this agent in the disease remains controversial.Aims—To investigate the presence and implications of HGV infection in a large series of Spanish patients with FHF.Patients—Sixty eight patients with FHF,

J C Sáiz; M Sans; A Mas; E Olmedo; X Forns; F X López-Labrador; J C Restrepo; J Costa; J M Salmerón; M Guilera; S Ampurdanés; J M Sánchez-Tapias; M T Jiménez de Anta; J Rodés

1997-01-01

343

Genetics Home Reference: Congenital hepatic fibrosis  

MedlinePLUS

... Research studies PubMed Recent literature Conditions > Congenital hepatic fibrosis On this page: Description Genetic changes Inheritance Diagnosis ... definitions Reviewed January 2012 What is congenital hepatic fibrosis? Congenital hepatic fibrosis is a disease of the ...

344

Hepatitis A and the Vaccine during Pregnancy  

MedlinePLUS

... or visit us online at: www.OTISpregnancy.org . Hepatitis A and the Vaccine during Pregnancy In every ... and advice from your healthcare professional. What is Hepatitis A? Hepatitis A is a short-term viral ...

345

Special report: Autoimmune hepatitis  

Microsoft Academic Search

Opinion statement  \\u000a \\u000a \\u000a \\u000a \\u000a – \\u000a \\u000a Autoimmune hepatitis can be treated effectively with either prednisone alone or a lower dose of prednisone in combination\\u000a with azathioprine.\\u000a \\u000a \\u000a \\u000a \\u000a – \\u000a \\u000a All types of autoimmune hepatitis should be treated similarly.\\u000a \\u000a \\u000a \\u000a \\u000a – \\u000a \\u000a The combination schedule of prednisone and azathioprine is preferred since it is associated with fewer side effects than a\\u000a higher dose of prednisone alone.\\u000a \\u000a \\u000a \\u000a \\u000a – \\u000a \\u000a Lifestyle

Albert J. Czaja

1999-01-01

346

[Acute hepatic vascular complications].  

PubMed

Acute hepatic vascular complications are rare. Acute portal vein thrombosis (PVT) and the Budd-Chiari syndrome (BSC) are the leading causes. Coagulopathy and local factors are present in up to 80% of cases. Diagnosis is established by colour-coded Doppler sonography, contrast-enhanced computed tomography or magnetic resonance imaging. Patients with acute PVT present with abdominal pain and disturbed intestinal motility. In the absence of cirrhosis anticoagulation with heparin is established followed by oral anticoagulation. In severe cases, surgical thrombectomy or transjugular thrombolysis with stent shunt may be necessary. Acute or fulminant BCS may require emergency liver transplantation or a transjugular intrahepatic portosystemic stent shunt, if patients present with acute liver failure. Milder cases receive anticoagulation for thrombolysis of occluded hepatic veins. Sinusoidal obstruction syndrome (SOS) is diagnosed after total body irradiation or chemotherapy, the term SOS replacing the former veno-occlusive disease. The treatment of congenital vascular malformations, complications in the setting of OLTX as well as patients with hepatic involvement of hereditary hemorrhagic telangiectasia requires significant expertise in a multidisciplinary approach. PMID:21667100

Ochs, A

2011-07-01

347

Hepatitis E Virus Infection  

PubMed Central

SUMMARY Hepatitis E virus (HEV) infection is a worldwide disease. An improved understanding of the natural history of HEV infection has been achieved within the last decade. Several reservoirs and transmission modes have been identified. Hepatitis E is an underdiagnosed disease, in part due to the use of serological assays with low sensitivity. However, diagnostic tools, including nucleic acid-based tests, have been improved. The epidemiology and clinical features of hepatitis E differ between developing and developed countries. HEV infection is usually an acute self-limiting disease, but in developed countries it causes chronic infection with rapidly progressive cirrhosis in organ transplant recipients, patients with hematological malignancy requiring chemotherapy, and individuals with HIV. HEV also causes extrahepatic manifestations, including a number of neurological syndromes and renal injury. Acute infection usually requires no treatment, but chronic infection should be treated by reducing immunosuppression in transplant patients and/or the use of antiviral therapy. In this comprehensive review, we summarize the current knowledge about the virus itself, as well as the epidemiology, diagnostics, natural history, and management of HEV infection in developing and developed countries. PMID:24396139

Dalton, Harry R.; Abravanel, Florence; Izopet, Jacques

2014-01-01

348

Alcoholic hepatitis: current management.  

PubMed

Alcoholic hepatitis is an acute manifestation of alcoholic liver disease with mortality as high as 40-50% in severe cases. Patients usually have a history of prolonged alcohol abuse with or without a known history of liver disease. Although there is significant range in severity at presentation, patients with severe alcoholic hepatitis typically present with anorexia, fatigue, fever, jaundice, and ascites. The use of either pentoxifylline or corticosteroids in those with severe disease (Maddrey's discriminate function >32) has significant mortality benefit. The addition of N-acetylcysteine to corticosteroids decreases the incidences of hepatorenal syndrome, infection, and short-term mortality, but does not appear to significantly affect 6-month mortality. Nutritional support with high-calorie, high-protein diet is recommended in all patients screening positive for malnutrition. Liver transplantation for a highly selected group of patients with severe alcoholic hepatitis may be an option in the future, but is not currently recommended or available at most transplant institutions. PMID:24798996

Spengler, Erin K J; Dunkelberg, Jeffrey; Schey, Ron

2014-10-01

349

Guiding the Giant  

NASA Astrophysics Data System (ADS)

New ESO Survey Provides Targets for the VLT Giant astronomical telescopes like the ESO Very Large Telescope (VLT) must be used efficiently. Observing time is expensive and there are long waiting lines of excellent research programmes. Thus the work at the telescope must be very well prepared and optimized as much as possible - mistakes should be avoided and no time lost! Astronomers working with the new 8-m class optical/infrared telescopes must base their observations on detailed lists of suitable target objects if they want to perform cutting-edge science. This is particularly true for research programmes that depend on observations of large samples of comparatively rare, distant objects. This type of work requires that extensive catalogues of such objects must be prepared in advance. One such major catalogue - that will serve as a very useful basis for future VLT observations - has just become available from the new ESO Imaging Survey (EIS). The Need for Sky Surveys Astronomers have since long recognized the need to carry out preparatory observations with other telescopes in order to "guide" large telescopes. To this end, surveys of smaller or larger parts of the sky have been performed by wide-field telescopes, paving the way for subsequent work at the limits of the largest available ground-based telescopes. For instance, a complete photographic survey of the sourthern sky (declination < -17.5°) was carried out in the 1970's with the ESO 1-metre Schmidt Telescope in support of the work at the 3.6-m telescope at the ESO La Silla observatory. However, while until recently most observational programmes could rely on samples of objects found on photographic plates, this is no longer possible. New image surveys must match the fainter limiting magnitudes reached by the new and larger telescopes. Modern digital, multi-colour, deep imaging surveys have thus become an indispensable complement to the 8-m telescopes. The new generation of imaging surveys will, without doubt, be the backbone of future research and are likely to be as long-lived as their earlier counterparts, which have served the astronomical community so well over the past decades. The new surveys are now becoming possible, thanks to the new, extremely light-sensitive CCD-mosaics mounted on wide-field telescopes. The ESO Imaging Survey (EIS) A very successful, major step in this direction has recently been taken at ESO. It concerns an imaging survey with the 3.5-m New Technology Telescope (NTT) at La Silla, aimed at defining targets for the first year of operation of the VLT. In addition to serving the future observers, this survey is also public , i.e., the resulting data are made available to all interested parties. The project is known as the ESO Imaging Survey (EIS). It is supervised by a Working Group with members from the European astronomical community ( [1]) that has been responsible for defining the survey strategy and for monitoring the progress. It has been a major challenge to carry out such a public survey in the very short time available. The work by the EIS Team has involved the survey observations at the NTT, development of a pipeline to process the raw data, advanced data reduction, identification of large samples of astronomically "interesting" targets and, not least, the distribution of images and other survey products before the start of operation of the VLT. To cope with the ambitious one-year timetable, a novel type of collaboration between ESO and the astronomical communities in the ESO Member States was set up. It has allowed to combine efficiently the scientific and technical expertise of the community with ESO in-house know-how and infrastructure. This model has been very successful and may well set the example for future surveys. Science Goals of EIS EIS is in many aspects a novel approach for large-scale, ground-based optical observations, in support of large-telescope science. The speed with which raw EIS data have been converted to deliverable products is quite unprecedented, given the nature and scope of t

1998-08-01

350

Sexual transmission of viral hepatitis.  

PubMed

Identification and vaccination of adults at risk for hepatitis B virus acquisition through sexual contact is a key strategy to reduce new hepatitis B virus infections among at-risk adults. Hepatitis C has emerged as a sexually transmitted infection among men with male sex partners (MSM). Several biological and behavioral factors have been linked to hepatitis C virus transmission among MSM, including human immunodeficiency virus coinfection; participation in sexual practices that result in mucosal damage or result in exposure to blood; presence of sexually transmitted diseases (STIs), particularly ulcerative STIs; multiple/casual sex partners; and unprotected anal intercourse. PMID:24275272

Gorgos, Linda

2013-12-01

351

Radioembolization of hepatic tumors  

PubMed Central

Unresectable primary and metastatic liver tumors are a leading cause of cancer mortality and morbidity. This remains a challenging and key task for every oncologist despite significant advances that have been made with selective targeted systemic agents and in technology advances with radiotherapy delivery. Radioembolization (RE) is a technique of permanently implanting microspheres containing Yttrium-90 (90Y), a beta-emitting isotope with a treatment range of 2 mm, into hepatic tumors. This form of brachytherapy utilizes the unique dual vascular anatomy of the liver to preferentially deliver radioactive particles via the hepatic artery to tumor, sparing normal liver parenchyma. The main treatment inclusion criteria are patients with solid tumors, compensated liver functions, life expectancy of at least three months, and ECOG performance status 0-2. Benefit of RE has been proven in patients that have low-to-moderate extrahepatic disease burden, prior liver radiotherapy, heavy prior chemotherapy and biologic agent exposure, and history of hepatic surgery or ablation. Most of the clinical evidence is reported in metastatic colorectal, and neuroendocrine tumors (NET), and primary hepatocellular cancer. A growing body of data supports the use of RE in hepatic metastatic breast cancer, intrahepatic cholangiocarinoma, and many other metastatic tumor types. Side effects are typically mild constitutional and GI issues limited to the first 7-14 days post treatment, with only 6% grade 3 toxicity reported in large series. Potentially serious or fatal radiation induced liver disease is extremely rare, reported in only 1% or fewer in major series of both metastatic and primary tumors treated with RE. Currently, high priority prospective clinical trials are testing RE combined with chemotherapy in first line therapy for colorectal hepatic metastases, and combined with sorafenib for hepatocellular carcinomas (HCCs). Fortunately, this beneficial and now widely available therapy is being increasingly incorporated into the standard therapy algorithms of multidisciplinary GI cancer teams worldwide. This form of radiotherapy differs significantly from daily external beam radiotherapy in many ways, particularly in dose rate, dosimetric coverage and duration of radiation delivery, side effects, and patient selection factors. A wealth of experience using RE in solid tumors exists and ongoing major prospective clinical trials will soon clarify the role of RE in the management of metastatic colorectal liver metastases. PMID:24982766

2014-01-01

352

Radioembolization of hepatic tumors.  

PubMed

Unresectable primary and metastatic liver tumors are a leading cause of cancer mortality and morbidity. This remains a challenging and key task for every oncologist despite significant advances that have been made with selective targeted systemic agents and in technology advances with radiotherapy delivery. Radioembolization (RE) is a technique of permanently implanting microspheres containing Yttrium-90 ((90)Y), a beta-emitting isotope with a treatment range of 2 mm, into hepatic tumors. This form of brachytherapy utilizes the unique dual vascular anatomy of the liver to preferentially deliver radioactive particles via the hepatic artery to tumor, sparing normal liver parenchyma. The main treatment inclusion criteria are patients with solid tumors, compensated liver functions, life expectancy of at least three months, and ECOG performance status 0-2. Benefit of RE has been proven in patients that have low-to-moderate extrahepatic disease burden, prior liver radiotherapy, heavy prior chemotherapy and biologic agent exposure, and history of hepatic surgery or ablation. Most of the clinical evidence is reported in metastatic colorectal, and neuroendocrine tumors (NET), and primary hepatocellular cancer. A growing body of data supports the use of RE in hepatic metastatic breast cancer, intrahepatic cholangiocarinoma, and many other metastatic tumor types. Side effects are typically mild constitutional and GI issues limited to the first 7-14 days post treatment, with only 6% grade 3 toxicity reported in large series. Potentially serious or fatal radiation induced liver disease is extremely rare, reported in only 1% or fewer in major series of both metastatic and primary tumors treated with RE. Currently, high priority prospective clinical trials are testing RE combined with chemotherapy in first line therapy for colorectal hepatic metastases, and combined with sorafenib for hepatocellular carcinomas (HCCs). Fortunately, this beneficial and now widely available therapy is being increasingly incorporated into the standard therapy algorithms of multidisciplinary GI cancer teams worldwide. This form of radiotherapy differs significantly from daily external beam radiotherapy in many ways, particularly in dose rate, dosimetric coverage and duration of radiation delivery, side effects, and patient selection factors. A wealth of experience using RE in solid tumors exists and ongoing major prospective clinical trials will soon clarify the role of RE in the management of metastatic colorectal liver metastases. PMID:24982766

Kennedy, Andrew

2014-06-01

353

Immunology of hepatitis B virus and hepatitis C virus infection  

Microsoft Academic Search

More than 500 million people worldwide are persistently infected with the hepatitis B virus (HBV) and\\/or hepatitis C virus (HCV) and are at risk of developing chronic liver disease, cirrhosis and hepatocellular carcinoma. Despite many common features in the pathogenesis of HBV- and HCV-related liver disease, these viruses markedly differ in their virological properties and in their immune escape and

Michelina Nascimbeni; Barbara Rehermann

2005-01-01

354

Giant landslides from the inside  

NASA Astrophysics Data System (ADS)

Despite the growing literature on catastrophic long-runout landslides, few studies have systematically examined sedimentary and petrographic characteristics of the interior of large landslide deposits, which yield valuable insights into dynamics during motion and final emplacement. We summarize petrographic evidence of dynamic rock fragmentation, internal sliding surfaces, and basal frictional melt that together allow constraining the dynamics and emplacement mechanisms of nine giant (> 1 km3) landslides in the Alps, the Himalayas, and the Tien Shan. We find that the fractal particle size distribution in some of these rock-avalanche deposits is similar to that found for fault-zone rocks, deforming glacial tills, and volcanic debris avalanches, suggesting a strong link through a formational mechanism consistent with confined comminution models. We propose a model in which giant landslide sedimentology evolves during runout, from initially intact, discontinuity-defined rock slides with shear focused at the base, to the final stratified fragmented sand and gravel deposits. Mature deposits show shear distributed throughout the mass with near equal probability of fragmentation across all clast sizes with additional zones of concentrated shear related to weak lithologies. We argue that exposures of micro-breccias and frictionite (=hyalomylonite) in the debris and at the basal shear planes are indispensable as a tool for identifying giant landslides and distinguishing them from superficially similar Quaternary glacial deposits. Recognizing these tell-tale petrographic indicators is crucial, in particular where the scarcity of geomorphic evidence typically used for detecting large landslides (e.g. displaced ridge lines, cirque-shaped detachment scars, hummocky terrain, flow lobes, and impounded sediments) may lead to grave underestimates of both the recurrence and residence time of giant slope failures.

Weidinger, J. T.; Dunning, S.; Korup, O.

2009-04-01

355

Annular elastolytic giant cell granuloma.  

PubMed

Annular elastolytic giant cell granuloma (AEGCG) is a clinical and histological entity, which has been described previously in various different terms. Knowledge of AEGCG is of importance, since its misdiagnosis may lead to improper therapy; e.g. longterm tuberculostatic or corticosteroid treatment. In the present paper two patients with typical AEGCG are described and the clinical and histological differential diagnosis is discussed in detail. PMID:6630664

Schwarz, T; Lindlbauer, R; Gschnait, F

1983-10-01

356

Giant cell tumor of bone.  

PubMed

Giant cell tumor (GCT) of bone is one type of giant cell-rich lesion of bone. This benign mesenchymal tumor has characteristic multinuclear giant cells. Mononuclear stromal cells are the physiologically active and diagnostic cell type. Most GCTs are located in the epiphyseal regions of long bones. The axial skeleton-primarily the sacrum-is a secondary site of involvement. Most patients present with pain, swelling, joint effusion, and disability in the third and fourth decades of life. Imaging studies are important for tumor staging and radiographic grading. Typically, these clinically active but slow-growing tumors are confined to bone, with relatively well-defined radiographic borders. Monostotic disease is most common. Metastatic spread to the lungs is rare. Extended intralesional curettage with or without adjuvant therapy is the primary treatment choice. Local recurrence is seen in ? 20% of cases, and a second local intralesional procedure is typically sufficient in cases that are detected early. Medical therapies include diphosphonates and denosumab. Denosumab has been approved for use in osteoporosis as well as breast and prostate cancer metastatic to bone. Medical therapy and radiotherapy can alter the management of GCT of bone, especially in multifocal disease, local recurrences, and bulky central/axial disease. PMID:23378375

Raskin, Kevin A; Schwab, Joseph H; Mankin, Henry J; Springfield, Dempsey S; Hornicek, Francis J

2013-02-01

357

Observed Properties of Giant Cells  

NASA Technical Reports Server (NTRS)

The existence of Giant Cells has been suggested by both theory and observation for over 45 years. We have tracked the motions of supergranules in SDO/HMI Doppler velocity data and find larger (Giant Cell) flows that persist for months. The flows in these cells are clockwise around centers of divergence in the north and counter-clockwise in the south. Equatorward flows are correlated with prograde flows - giving the transport of angular momentum toward the equator that is needed to maintain the Sun's rapid equatorial rotation. The cells are most pronounced at mid- and high-latitudes where they exhibit the rotation rates representative of those latitudes. These are clearly large, long-lived, cellular features, with the dynamical characteristics expected from the effects of the Sun's rotation, but the shapes of the cells are not well represented in numerical models. While the Giant Cell flow velocities are small (<10 m/s), their long lifetimes should nonetheless substantially impact the transport of magnetic flux in the Sun's near surface layers.

Hathaway, David H.; Upton, Lisa; Colegrove, Owen

2014-01-01

358

Risk Factors for Giant Retinal Tears  

PubMed Central

Purpose To evaluate the risk factors associated with giant retinal tears. Methods This retrospective study was performed on medical records of 150 patients who had undergone retinal detachment surgery. Age, sex, history of trauma, lens status (phakic, pseudophakic, or aphakic), and high myopia were evaluated in association with giant retinal tears. Results Of 150 patients with retinal detachments, 99 subjects (66%) were older than 30 years while 51 (34%) were 30 years of age or younger. Overall, 26 (17.3%) patients had giant retinal tears. Controlling for all variables, only age had a significant correlation with giant retinal tears. Each year of advancing age was associated with a 6% decrease in the incidence of giant retinal tears. Conclusion Young age is a significant risk factor for development of giant retinal tears. PMID:22737369

Mehdizadeh, Morteza; Afarid, Mehrdad; Haqiqi, Mohammad Shabanpour

2010-01-01

359

Hepatitis C and Ozone Therapy  

Microsoft Academic Search

Hepatitis C (HCV) is a global disease with a worldwide expanding incidence and prevalence base. Of massive public health importance, hepatitis C presents supremely challenging problems in view of its adaptability and its pathogenic capacity. The unique strategies that HCV utilizes to parasitize its hosts make it a formidable enemy and therapeutic interventions need considerable sophistication to counter its progress.

Gerard V. Sunnen

360

[Hepatitis in dogs; a review].  

PubMed

As with most liver diseases, the symptoms of hepatitis in dogs are nearly always aspecific: the dogs eat less, are apathetic, sometimes have polyuria/polydipsia, and sometimes have diarrhoea. Hepatoencephalopathy and ascites only occur with these symptoms in very advanced stages of chronic hepatitis. Only a part of the dogs have jaundice. Because of these aspecific symptoms, the diagnosis hepatitis is often not taken into consideration, even though the presence of a liver disease can be easily detected by measuring plasma concentrations of alkaline phosphatase and bile acids, one or both of which are elevated. The diagnosis is confirmed by histological examination of a liver biopsy sample. The most common forms of hepatitis are non-specific reactive hepatitis, acute hepatitis, and chronic hepatitis. Non-specific reactive hepatitis is a reaction against endotoxin as a result of sepsis or an increased gastrointestinal absorption. Treatment is directed to the primary process. Leptospirosis also causes non-specific reactive hepatitis, but then renal insufficiency is the most prominent feature. The diagnosis is made not on the basis of a liver biopsy but on the basis of increased IgM titres against Leptospira. Immediate treatment with antibiotics and infusions at the first signs (jaundice and uraemia) can save the animal's life. Acute hepatitis can develop as a result of infection, toxins, or liver hypoxia. There is no specific treatment, but adequate recovery often occurs with supportive treatment. Corticosteroids are contraindicated. Chronic hepatitis, which can lead to cirrhosis, is the most common form of hepatitis. It is an autoimmune inflammatory reaction that is usually caused by a virus infection but sometimes by poisoning (intoxication). Long treatment with prednisolone or azathioprine is usually successful, but early recognition of the disease increases the likelihood of success. Nowadays, chronic hepatitis due to hepatic copper accumulation in Beddlington terriers can be detected by DNA tests. Such tests make it possible to distinguish between carriers and non-carriers. Affected animals can be kept symptom-free by life-long treatment with zinc gluconate or penicillamine. PMID:9584348

Rothuizen, J; van den Ingh, T S

1998-04-15

361

Spontaneous thrombosis in giant intracranial aneurysms.  

PubMed Central

Twelve patients in a series of 22 with giant intracranial aneurysms demonstrated neuroradiological features of partial or total spontaneous intra-aneurysmal thrombosis. The presence of this intra-aneurysmal clot significantly altered the computed tomographic appearance of the giant aneurysm. Massive intra-aneurysmal thrombosis did not protect against subarachnoid haemorrhage and the likelihood of rupture of a clot containing giant aneurysm was not significantly different from that of a non-thrombosed giant aneurysm. Although parent artery occlusion from a thrombosed giant aneurysm, and massive aneurysmal thrombosis leading to the formation of giant serpentine aneurysm were documented, these are rare epiphenomena. The risk of embolisation from a partially thrombosed giant aneurysm, which was documented in one case, would appear to be greater than that from a non-thrombosed giant aneurysm. The findings in this series, and a review of literature, suggest that the presence of intra-aneurysmal clot in giant intracranial aneurysms has little prognostic significance and does not alter the management or outcome after treatment. Images PMID:7175528

Whittle, I R; Dorsch, N W; Besser, M

1982-01-01

362

Speciation and phylogeography of giant petrels Macronectes.  

PubMed

We examine global phylogeography of the two forms of giant petrel Macronectes spp. Although previously considered to be a single taxon, and despite debate over the status of some populations and the existence of minimal genetic data (one mitochondrial cytochrome b sequence per form), the current consensus based on morphology is that there are two species, Northern Giant Petrel M. halli and Southern Giant Petrel M. giganteus. This study examined genetic variation at cytochrome b as well as six microsatellite loci in giant petrels from 22 islands, representing most island groups at which the two species breed. Both markers support separate species status, although sequence divergence in cytochrome b was only 0.42% (corrected). Divergence was estimated to have occurred approximately 0.2mya, but with some colonies apparently separated for longer (up to 0.5 my). Three clades were found within giant petrels, which separated approximately 0.7mya, with the Southern Giant Petrel paraphyletic to a monophyletic Northern Giant Petrel. There was evidence of past fragmentation during the Pleistocene, with subsequent secondary contact within Southern Giant Petrels. The analysis also suggested a period of past population expansion that corresponded roughly to the timing of speciation and the separation of an ancestral giant petrel population from the fulmar Fulmarus clade. PMID:19755164

Techow, N M S M; O'Ryan, C; Phillips, R A; Gales, R; Marin, M; Patterson-Fraser, D; Quintana, F; Ritz, M S; Thompson, D R; Wanless, R M; Weimerskirch, H; Ryan, P G

2010-02-01

363

Occult hepatitis B among Iranian hepatitis C patients  

PubMed Central

BACKGROUND: Occult hepatitis B is defined as presence of HBV DNA in tissue or serum without hepatitis B surface antigen. The aim of this study is to determine frequency of occult hepatitis B among hepatitis C patients in Tehran and compare the route of transmission and liver enzymes between positive and negative HBV DNA patients. METHODS: In a cross sectional study, serum of 103 hepatitis C cases (79.6% men and 20.4% women) were analyzed for s, x and core genes via a nested polymerase chain reaction technique. RESULTS: HBV DNA was detectable in serum of 20 patients (19.4%). No significant difference in age, sex and route of transmission were seen in HBV DNA positive and negative patients. In HBV DNA positive and negative groups, mean of AST was 73, 47 (p < 0.05) and mean of ALT was 76 and 36 respectively (p < 0.05). CONCLUSION: Occult hepatitis B was observed in a considerable number of hepatitis C patients in Tehran. It was associated with elevation in liver enzyme but was not related to route of transmission. PMID:21772856

Shavakhi, Ahmad; Norinayer, Babak; Esteghamat, Fateme Sadat; Seghatoleslami, Mohamad; Khodadustan, Mahsa; Somi, Mohamad Hosein; Masoodi, Mohsen; Zali, Mohamad Reza

2009-01-01

364

[Cholecystolithiasis as a cause of local hepatitis].  

PubMed

In an acute inflammation of gallbladder inflammatory process spreads on surrounding tissues, including hepatic tissue, what causes the regional hepatitis occurrence. In some patients, suffering calculous cholecystitis on background of transition of inflammatory process from gallbladder to hepatic tissue likewise a regional hepatitis, hyperbilirubinemia, the skin yellowness are revealed, what simulates choledocholithiasis and obturation jaundice. PMID:25417284

Dolimov, K S; Il'khamov, F A; Abdumazhidov, A Sh; Tukhtamuradov, Z Z; Dolimov, T K; Pivnitski?, I O

2014-08-01

365

Giant lipoma of the breast.  

PubMed

Lipomas are benign mesenchymal tumors that develop in areas of abundant adipose tissue. Due to the fatty composition of the breast, difficulties in diagnosis, treatment, and reconstruction are often encountered. We report a case of a 55-year-old female with a giant tumor of the right breast that comprised most of its mass, causing breast asymmetry. A thorough preoperative evaluation, followed by an uneventful difficult surgical resection and reconstruction, resulted in diagnosis of a benign lipoma. The case prompted this report because of its challenging size, location, diagnosis, and reconstructive solution. PMID:23730601

Ramírez-Montaño, Luis; Vargas-Tellez, Erik; Dajer-Fadel, Walid L; Espinosa Maceda, Silvia

2013-05-01

366

Annular elastolytic giant cell granuloma.  

PubMed

We treated a 13-year-old girl who had annular erythematous lesions with central atrophic areas, which had been present on her trunk and limbs for 4 months. Histological examination revealed patchy dermal lymphohistocytic infiltration with multinucleated giant cells which were phagocytosing elastic fibers, causing them to disappear. The active border of the lesions regressed after intradermal injection of corticosteroids. The classification of the disease and its differential diagnosis from the usual granuloma annulare, inflammatory anetoderma, O'Brien's actinic granuloma, and Convit's disease are discussed. PMID:3232752

Boneschi, V; Brambilla, L; Fossati, S; Parini, F; Alessi, E

1988-06-01

367

Giant odontogenic fibroma of maxilla  

PubMed Central

Odontogenic fibroma is a benign ectomesenchymal tumor classified as central and peripheral on the basis of its location and as an epithelium rich or epithelium poor based on its histological features. Radiological findings consist of radiolucent areas with well-defined bony margins. The lesion is detected early because of its location and usually treated with surgical excision and curettage. We present a case of giant odontogenic fibroma of right maxilla presenting as gross facial deformity and posing a dual challenge of excising the tumor mass and reconstructing the ensuing defect.

Baser, Brajendra; Kinger, Arvind; Mitra, Geeti V.; Roy, Manya Thakur

2014-01-01

368

Do red giants have short mode lifetimes?  

E-print Network

We show evidence that the red giant star ksi Hya has an oscillation mode lifetime, tau, of about 2 days significantly shorter than predicted by theory (tau = 17 days, Houdek & Gough 2002). If this is a general trend of red giants it would limit the prospects of asteroseismology on these stars because of poor coherence of the oscillations.

D. Stello; H. Kjeldsen; T. R. Bedding; D. Buzasi

2005-10-18

369

Giant monopole resonance strength in Si-28  

E-print Network

The giant resonance region in Si-28 was studied with inelastic scattering of 240 MeV alpha particles at small angles including 0 degrees. The giant resonance peak extended from E-x=12 MeV to 35 MeV and E0 strength corresponding to 54 +/- 6...

Youngblood, David H.; Clark, HL; Lui, YW.

1998-01-01

370

Genetics Home Reference: Giant axonal neuropathy  

MedlinePLUS

... What if I still have specific questions about giant axonal neuropathy? Ask the Genetic and Rare Diseases Information Center . Where can I find general ... Health Professionals What glossary definitions help with understanding giant axonal ... (11 links) The resources on this site should not be used as a substitute for ...

371

Giant cell tumor of the capitate.  

PubMed

Giant cell tumors are primary bone tumors most often observed in the metaepiphyses of long bones; location in the hand, especially the carpal bones, is rare. We report a patient with recurrent giant cell tumor of the capitate and discuss treatment and prognosis in this rare site. PMID:21373912

Angelini, Andrea; Mavrogenis, Andreas F; Ruggieri, Pietro

2011-04-01

372

Giant osteochondroma of the talar neck.  

PubMed

Giant osteochondroma is an uncommon entity and it is rare in the foot and ankle region. It is extremely rare to originate from the talus. In this case report we present a case of giant osteochondroma arising from the talar neck measuring 100 mm × 90 mm × 30 mm. It is unique because of the size, site and the age at presentation. PMID:23415762

Al Mutani, Mohammed; Mahmood, Aatif; Chandrasekar, C R

2013-03-01

373

Giant-Magnetoresistance 7.1 Introduction  

E-print Network

Chapter 7 Angular Giant-Magnetoresistance 7.1 Introduction In the previous chapter we considered F for magnetoresistance Defs. (1.3) and (1.4) we utilize: Definition 3 The angular magnetoresistance of GMR systems is defined as either I() g(0) g() - 1, (7.1) #12;114 CHAPTER 7. ANGULAR GIANT-MAGNETORESISTANCE c Mixed

374

Giant magnetoresistance in spin-valve multilayers  

Microsoft Academic Search

A comprehensive review of giant magnetoresistance in spin-valve sandwiches and multilayers is presented, highlighting the experimental and theoretical results which are of particular interest for the development of applications of these systems, especially in magnetic recording technology. The main points discussed include the physical origin of the giant magnetoresistance, the influence of the thicknesses of the magnetic and nonmagnetic layers,

B. Dieny

1994-01-01

375

Young Solar System's Fifth Giant Planet?  

Microsoft Academic Search

Studies of solar system formation suggest that the solar system's giant planets formed and migrated in the protoplanetary disk to reach the resonant orbits with all planets inside ~15 AU from the Sun. After the gas disk's dispersal, Uranus and Neptune were likely scattered by the gas giants, and approached their current orbits while dispersing the transplanetary disk of planetesimals,

David Nesvorný

2011-01-01

376

Contrast-enhanced ultrasonography in nodular splenomegaly associated with type B Niemann–Pick disease: an atypical hemangioma enhancement pattern  

PubMed Central

Introduction Niemann–Pick disease (NPD) types A and B are lipid storage disorders. NPD type A is a fatal disorder of infancy. Type B is a non-neuronopathic form observed in children and adults. It is associated with enlargement of the liver, spleen, or both, and nodular splenomegaly may be detected with ultrasound. Methods A 21-year-old female was admitted to the Emergency Room with fever, pharyngitis, and left upper quadrant abdominal pain. Labwork revealed anemia, thrombocytopenia, increased levels of AST, ALT, GGT, AF, LDH, triglycerides, and total cholesterol and low levels of HDL-cholesterol. PCR blood assays for CMV and EBV were both negative. Chest X-ray was unremarkable. Transabdominal B-mode ultrasound (US) revealed splenomegaly (long axis: >22 cm), an irregular subcapsular hypoechoic lesion in the superior pole that was consistent with splenic infarction, and multiple round highly echogenic nodes measuring 1–5 cm in diameter. Contrast-enhanced ultrasonography (CEUS) was performed using SonoVue® (Bracco). Results The presence of a splenic infarction was confirmed. The nodular lesions showed arterial-phase enhancement with late parenchymal phase wash-out. 18F-FDG-PET revealed splenic nodular uptake. Primary splenic lymphoma was suspected, and the patient underwent open splenectomy. The diagnosis was type B NPD with splenic hemangiomas. Discussion CEUS confirmed the diagnosis and extent of splenic infarction, but the nodular atypical enhancement pattern together with nodular 18F-FDG-PET uptake was misleading, suggesting as it did lymphoproliferative involvement of the spleen. PMID:23396497

Benedetti, E.; Proietti, A.; Miccoli, P.; Basolo, F.; Ciancia, E.; Erba, P.A.; Galimberti, S.; Orsitto, E.; Petrini, M.

2009-01-01

377

Utility of R2* Obtained from T2*-Weighted Imaging in Differentiating Hepatocellular Carcinomas from Cavernous Hemangiomas of the Liver  

PubMed Central

Purpose To evaluate the feasibility of applying R2* values to differentiate hepatocellular carcinomas (HCC) from cavernous hemangiomas of the liver (CHL). Materials and Methods This retrospective study was approved by the participating Institutional Review Board and written informed consent for all subjects were obtained. Seventy-three patients with 79 pathologically identified HCCs and 65 patients with 91 clinically or pathologically identified CHLs were enrolled in this study. All subjects underwent a breath-hold multi-echo T2* weighted MR imaging on a 1.5T clinical MR scanner. R2* values from HCC and CHL groups were compared using the Mann-Whitney non-parametric U test. A cut-off value of R2* was evaluated with receiver operator characteristic (ROC) analysis. Results The mean R2* value was 23.32±12.23 Hz (95% confidence interval [CI]: 20.58 Hz, 26.06 Hz) for the HCC group, and 3.66±2.37 Hz (95% CI: 3.17 Hz, 4.15 Hz) for the CHL group. The mean R2* value for HCC was significantly higher than that of CHL (p<0.001). A threshold of 9.48 Hz for the minimum R2* value in the diagnosis of HCC resulted in a sensitivity of 96.20% (76 out of 79 patients), and a specificity of 97.80% (89 out of 91 patients). The positive predictive value (PPV), negative predictive value (NPV) and diagnostic accuracy for HCC were 97.44% (76 out of 78 patients), 96.74% (89 out of 92 patients) and 97.06% (165 out of 170 patients), respectively. The AUC for differentiation between these two groups was 0.994 (95% CI: 0.980, 1.000). Conclusions R2* is a significant MRI biomarker to differentiate HCC from CHL with satisfying sensitivity and specificity. PMID:24632579

Sun, Meiyu; Wang, Sheng; Song, Qingwei; Wang, Zhiyuan; Wang, Heqing; Ning, Dianxiu; Xu, Bin; Wei, Qiang; Liu, Ailian

2014-01-01

378

Giant Coronary Artery Aneurysms: Review and Update  

PubMed Central

Giant coronary artery aneurysms are rare, with a reported prevalence of 0.02% to 0.2%. Causative factors include atherosclerosis, Takayasu arteritis, congenital disorders, Kawasaki disease, and percutaneous coronary intervention. Most giant coronary artery aneurysms are asymptomatic, but some patients present with angina pectoris, sudden death, fistula formation, pericardial tamponade, compression of surrounding structures, or congestive heart failure. Clinical sequelae include thrombus formation, embolization, fistula formation, and rupture. Surgical correction is generally accepted as the preferred treatment for giant coronary artery aneurysms. We present an illustrative case of a giant 70 × 40-mm coronary artery aneurysm in a 56-year-old man who declined surgery and died one month later. In addition, we provide a review of the medical literature on giant coronary artery aneurysms.

Crawley, Patricia D.; Huntsinger, D. Russell; Afiniwala, Swara; Wortham, Dale C.

2014-01-01

379

Hepatitis B vaccination.  

PubMed

Hepatitis B virus is a worldwide leading cause of acute and chronic liver disease including cirrhosis and hepatocellular carcinoma. Effective vaccines have been available since the early '80s and vaccination has proved highly successful in reducing the disease burden, the development of the carrier state and the HB-related morbidity and mortality in the countries where vaccination has been implemented.   Neutralizing (protective) antibodies (anti-HBs) induced by vaccination are targeted largely towards the amino acid hydrophilic region, referred to as the common a determinant which is present on the outer protein coat or surface antigen (HBsAg), spanning amino acids 124-149. This provides protection against all HBV genotypes (from A to H) and is responsible for the broad immunity afforded by hepatitis B vaccination. Thus, alterations of residues within this region of the surface antigen may determine conformational changes that can allow replication of the mutated HBV in vaccinated people. An important mutation in the surface antigen region was identified in Italy some 25 years ago in infants born to HBsAg carrier mothers who developed breakthrough infections despite having received HBIG and vaccine at birth. This virus had a point mutation from guanosine to adenosine at nucleotide position 587, resulting in aa substitution from glycine (G) to arginine (R) at position 145 in the a determinant. Since the G145R substitution alters the projecting loop (aa 139-147) of the a determinant, the neutralizing antibodies induced by vaccination are no longer able to recognize the mutated epitope. Beside G145R, other S-gene mutations potentially able to evade neutralizing anti-HBs and infect vaccinated people have been described worldwide. In addition, the emergence of Pol mutants associated with resistance to treatment with nucleos(t)ide analogues can select viruses with crucial changes in the overlapping S-gene, potentially able to alter the S protein immunoreactivity. Thus such mutants have the potential to infect both naïve and immunized people, negatively affecting the efficacy of both the antiviral treatment and the vaccination programs. Despite concern, at present the overall impact of vaccine escapes mutants seems to be low and they do not pose a public health threat or a need to modify the established hepatitis B vaccination programs. The development of novel NAs with a high barrier to resistance is warranted. PMID:25483515

Romanò, Luisa; Paladini, Sara; Galli, Cristina; Raimondo, Giovanni; Pollicino, Teresa; Zanetti, Alessandro R

2014-08-01

380

The hepatic-arterial/portal-venous scintiangiogram in alcoholic hepatitis  

SciTech Connect

This study was designed to identify abnormalities in the hepatic-arterial/portal-venous scintiangiogram (SA) in alcoholic hepatitis (AH). SA's were performed in 35 patients with acute alcoholic hepatitis (AAH), 8; acute alcoholic hepatitis superimposed on cirrhosis (A/C), 14; and cirrhosis (C), 13. Posterior flows were done with a bolus of 10 mCi Tc-99m sulfur colloid with computer time-activity curves over the liver and left kidney. Curves were analyzed for per cent of hepatic arterial (HA) and portal venous contribution using the slope ratio method. Hepatic arterialization was estimated from the angle of the HA component of the curve. Reversal of the relative contribution of the hepatic and portal components of total flow were seen in all groups. Although quite severe in AH, the degree of reversal could not be used to differentiate among the groups. The average HA angle in AAH was 48.3 +- 8.1, in A/C 41.5 +- 10.6, and in C 30.4 +- 12.1. In reviewing the data of only those in the acute clinical phase of AH and not the recovery phase (1 AAH, 3 A/C) and those without other causes of alteration in hepatic arterialization (1 hepatoma, 1 portalcaval shunt, 6 renal failure), the average HA angle in AAH was 50.1 +- 6.6, 45.4 +- 8.2 in A/C, and 23.2 +- 4.2 in C. In 6 with renal failure (2 C, 2AAH, 2 A/C) the HA angle ws 52.7 +- 5.7. In all cases cirrhosis could be differentiated from both A/C (P=.05) and AAH (P<.01) using the HA angle. In absence of renal failure, portal shunt, or hepatoma, P was <.01 in both comparisons.

Stewart, C.; Sakimura, I.; Siegel, M.E.; Harley, H.; Lee, K.

1984-01-01

381

Liver transplantation for neonatal hepatitis as compared to the other two leading indications for liver transplantation in children.  

PubMed

Neonatal hepatitis is a syndrome of unknown etiology occurring in children with viral liver disease, as well as children with unidentified disorders of bile salt synthesis and other poorly understood metabolic diseases. It is characterized by jaundice, giant cell hepatitis and rare liver failure necessitating liver transplantation. In the present investigation, the outcome of liver transplantation performed in 16 children with neonatal hepatitis at the investigators' institution was determined from 1 January 1989 to 31 December 1991. The results were compared to those obtained in 288 children transplanted for biliary atresia and 66 children transplanted for recognized metabolic liver disease. The children transplanted for neonatal hepatitis (4.1 +/- 1.3 years) and metabolic liver disease (5.8 +/- 0.6 years) were older than those transplanted for biliary atresia (3.3 +/- 0.2 years) (p < 0.01), but did not differ in terms of sex, ABO type, UNOS status or year in which the transplant procedure was performed. Interestingly, first allograft survival was equal in the children with neonatal hepatitis (74%) and those with metabolic liver disease (74%), but was greater than that for children transplanted for biliary atresia (68%) (p < 0.01). Despite this significant difference in first graft survival, no differences in 5-year survival were seen for the three groups (81% for neonatal hepatitis, 68% for biliary atresia and 79% for metabolic liver disease).(ABSTRACT TRUNCATED AT 250 WORDS) PMID:7699224

Adrian-Casavilla, F; Reyes, J; Tzakis, A; Wright, H I; Gavaler, J S; Lendoire, J; Gordon, R; Starzl, T E; Van Thiel, D H

1994-12-01

382

Biochemical laboratory tests in viral hepatitis and other hepatic diseases  

PubMed Central

The differential diagnosis between viral hepatitis and other liver diseases (particularly obstructive jaundice) is often difficult on purely clinical grounds. Damage to the liver causes changes in the pattern of the serum enzymes and this has led to the development in recent years of a number of enzyme tests. The authors have amassed evidence to show that the most useful of these is determination of the levels of serum glutamic oxalacetic and serum glutamic pyruvic transaminase (SGOT and SGPT), coupled with calculation of the SGOT/SGPT ratio. It is characteristic of viral hepatitis that both levels are greatly increased, but the SGOT/SGPT ratio, normally greater than one, falls considerably below his figure. In a few cases of obstructive jaundice, the serum transaminase picture may initially resemble that in viral hepatitis, but the differential diagnosis can be established by repeating the determinations at intervals. Other enzyme tests, such as determination of alkaline phosphatase and leucylaminopeptidase, may be used to confirm the biliary obstruction. Flocculation tests and electrophoretic determination of the plasma protein picture, while of limited value in the diagnosis of acute viral hepatitis, are useful in conjunction with the serum transaminase test for assessing the activity of the disease and any tendency to progress towards “active” chronic hepatitis or post-hepatic cirrhosis. PMID:14292063

De Ritis, Fernando; Giusti, Giuseppe; Piccinino, Felice; Cacciatore, Luigi

1965-01-01

383

[Prevention of hepatic encephalopathy].  

PubMed

Hepatic encephalopathy (HE) is a frequent complication of cirrhosis which, in addition to producing a great social impact, deteriorates the quality of life of patients and is considered a sign of advanced liver disease and therefore a clinical indication for liver transplant evaluation. Patients who have had episodes of HE have a high risk of recurrence. Thus, after the HE episode resolves, it is recommended: control and prevention of precipitating factors (gastrointestinal bleeding, spontaneous bacterial peritonitis, use of diuretics with caution, avoid nervous system depressant medications), continued administration of non-absorbable disaccharides such as lactulose or lactitol, few or non-absorbable antibiotics such as rifaximin and assess the need for a liver transplant as the presence of a HE episode carries a poor prognosis in cirrhosis. PMID:24480288

Morillas, Rosa M; Sala, Marga; Planas, Ramon

2014-06-01

384

Diabetes and Hepatitis B Vaccination  

MedlinePLUS

... for hepatitis B if they share blood glucose meters, fingerstick devices or other diabetes-care equipment such ... to have occurred from: • Use of blood glucose meter for more than one resident without cleaning and ...

385

Hepatitis viruses and liver transplantation.  

PubMed

Acute and chronic liver diseases related to hepatitis viruses are the main indications for liver transplantation. The risk of viral reinfection after transplantation is the main limiting factor in these indications. The risk of viral B reinfection is: 80% in the absence of prophylaxis; is related to the presence of active viral B replication prior to transplantation; is higher in patients with chronic liver disease, rather than with fulminant hepatitis; and is higher in patients with hepatitis B virus (HBV)-related liver disease alone rather than in those with HBV-hepatitis delta virus (HDV) infection. Post-transplant long-term passive antibody to hepatitis B (anti-HB) immunoprophylaxis reduces the risk of HBV recurrence to 30% in patients with HBV cirrhosis, and to less than 10% in those with fulminant hepatitis B. Patients with HBV-HDV liver disease receiving passive anti-HB immunoprophylaxis are at low risk of HBV recurrence (10-15%), but at high risk of HDV recurrence (80%). However, HDV reinfection of the graft has no clinicopathological consequence in the absence of concomitant HBV reinfection. The five year survival of patients transplanted for HBV cirrhosis and for HDV cirrhosis at the Hepatobiliary Center, Hôpital Paul Brousse is 72% and 85%, respectively. Hepatitis B virus reinfection of the graft is characterized by a high level of viral replication, and a chronic outcome. Antiviral treatments such as ganciclovir, adenine arabinoside monophosphate, famcyclovir, and lamivudine have a place after transplantation and may stop HBV replication, ganciclovir, famcyclovir and lamivudine should be continued for several months and in some cases indefinitely. Hepatitis C virus reinfection is almost constant, assessed by the persistence of hepatitis C virus (HCV)-RNA in the serum in 90% of cases. Acute lobular hepatitis appeared in 75% of patients at a median of 4 months post transplantation with a range of between 23 days and 4 years. In our series, the 5 year actuarial rate of HCV acute hepatitis on the graft, chronic hepatitis, and cirrhosis, is 75, 60, and 8%, respectively. Hepatitis C virus RNA level is dramatically increased after transplantation and seems to correlate with the occurrence of acute hepatitis on the graft. A positive relation between genotype 1b and prevalence and severity of HCV hepatitis on the graft have been suggested in European series. There is no demonstrated way to prevent HCV reinfection. The use of interferon for the treatment of HCV hepatitis on the graft was disappointing due to a poor antiviral effect and the occurrence of chronic rejection episodes in some patients. Promising results of the combination of interferon and ribavirine have been reported and need confirmation. The 5 year survival of patients transplanted for viral C cirrhosis at the Hepatobiliary Center, Hôpital Paul Brousse is 78%. In conclusion, patients with HBV cirrhosis and without HBV replication are candidates for liver transplantation. Long-term passive anti-HB prophylaxis is the best way to prevent HBV recurrence. Patients with HBV replication should be included in protocols using combinations of antiviral treatments and passive anti-HB immunoprophylaxis. Viral C reinfection is frequent, but medium-term survival is good. However, long-term graft and patient survival remains unknown and methods to prevent and treat HCV reinfection on the graft are needed. PMID:9407355

Samuel, D; Feray, C; Bismuth, H

1997-10-01

386

Reproduction of hemangioma by infection with subgroup J avian leukosis virus: the vertical transmission is more hazardous than the horizontal way  

PubMed Central

Background Clinical cases of hemangioma associated with subgroup J avian leukosis virus (ALV-J) have been reported in commercial chicken layer flocks since 2006. We attempted to reproduce hemangioma through experimental infection with ALV-J to evaluate viral pathogenicity in layer birds and their progenies. Results Body weight and indexes for immune organs of chickens infected with ALV-J strain SCDY1 were lower than those in controls. Proliferation of lymphocytes was observed in many tissues, and viral integration was detected in the genome of lymphocytes at 14 days post-infection, along with virus shedding. ALV-J was also efficiently transmitted from eggs to progenies. Embryo hatchability and progeny mortality were lower than those for controls. The efficiencies of virus shedding and virus integration in the lymphocytes of progenies were higher than those in parents. Conclusions ALV-J is able to inhibit the growth of infected chickens, and causes damage to immune organs. Vertical transmission of ALV-J appears to be more deleterious than horizontal transmission. PMID:23537218

2013-01-01

387

Separating gas-giant and ice-giant planets by halting pebble accretion  

NASA Astrophysics Data System (ADS)

In the solar system giant planets come in two flavours: gas giants (Jupiter and Saturn) with massive gas envelopes, and ice giants (Uranus and Neptune) with much thinner envelopes around their cores. It is poorly understood how these two classes of planets formed. High solid accretion rates, necessary to form the cores of giant planets within the life-time of protoplanetary discs, heat the envelope and prevent rapid gas contraction onto the core, unless accretion is halted. We find that, in fact, accretion of pebbles (~cm sized particles) is self-limiting: when a core becomes massive enough it carves a gap in the pebble disc. This halt in pebble accretion subsequently triggers the rapid collapse of the super-critical gas envelope. Unlike gas giants, ice giants do not reach this threshold mass and can only bind low-mass envelopes that are highly enriched by water vapour from sublimated icy pebbles. This offers an explanation for the compositional difference between gas giants and ice giants in the solar system. Furthermore, unlike planetesimal-driven accretion scenarios, our model allows core formation and envelope attraction within disc life-times, provided that solids in protoplanetary discs are predominantly made up of pebbles. Our results imply that the outer regions of planetary systems, where the mass required to halt pebble accretion is large, are dominated by ice giants and that gas-giant exoplanets in wide orbits are enriched by more than 50 Earth masses of solids.

Lambrechts, M.; Johansen, A.; Morbidelli, A.

2014-12-01

388

Giant ancient retroperitoneal schwannoma to retroperitoneal giant ancient schwannoma.  

PubMed

Ancient schwannoma is a rare variant of benign peripheral nerve sheath tumor, often morphologically mimicking malignancy. Retroperitoneum is an uncommon location. We describe one case of giant retroperitoneal ancient schwannoma. Literature concerning this variant is also reviewed. A 65 year old male presented with altered bowel habits. Imaging findings revealed a large heterogeneous mass in the retroperitoneum. The patient was treated with complete excision. Grossly, the tumor was predominantly solid with focal cystic degeneration. Histological examination showed an encapsulated spindle cell tumor with nuclear palisading, very focal nuclear atypia and widespread foam cell infiltration - findings consistent with ancient schwannoma. A diagnosis of ancient schwannoma can be considered for a solid-cystic encapsulated mass in the retroperitoneum. Malignant transformation is very rare. Local recurrence is uncommon following complete excision. The authors have nothing to disclose. PMID:25481325

Khandakar, Binny; Dey, Soumit; Chandra Paul, Prabir; Medda, Sriparna; Bhattacharya, Aparna; Datta, Saikat

2014-12-01

389

Panoramix: The Red Giant Heartbeat Star  

NASA Astrophysics Data System (ADS)

The study of stellar pulsations has improved dramatically over the recent years, in particular for the field of red giants. Through the study of solar-like oscillations, not only can we determine the evolutionary state, mass and radius of a red giant, but also determine the rotation rate and tilt of the rotation axis. In parallel, the study of binary stars forms the foundation of our knowledge of fundamental stellar parameters and has enabled us to populate the mass-radius diagram for a wide range of stellar masses and evolutionary states, including red giants. Heartbeat stars are eccentric ellipsoidals that undergo strong interactions at periastron. The signature of these interactions is a feature in the light curve similar to that of a cardiogram. Panoramix is a heartbeat star with a red giant component and that enables us to apply and compare the methods of these two astronomical fields. By modelling this feature using the Kepler photometric data and Hermes radial velocity data for the red giant, we have determined the fundamental and orbital parameters of the components of Panoramix. Due to the orientation of the orbit and velocity of the red giant, a notable attribute of the light curve is Doppler boosting, which we have included in our model. By incorporating the asteroseismic mass of the red giant into our binary analysis, we have determined the radius of the red giant and the mass of the secondary component. From the combination of these two methods we have also been able to determine the spin-orbital alignment of the red giant component.

Hambleton, Kelly; Beck, P.; Bloemen, S.; Vos, J.; Prsa, A.; Kurtz, D.; Aerts, C.

2013-07-01

390

[Unusual presentation of giant thymolipoma].  

PubMed

Thymolipoma is a rare thymic tumor; His frequency is estimated at 2 at 9% of all thymic tumors. His diagnosis usually easy, can be difficult with an unusual radio clinic pattern, but actually get benefice from progress in radiologic investigations especially MRI. We reported a case of a 36-year old woman, admitted for a left pleuro-pneumopathy investigation. Evolution, after antibiotic treatment and pleural effusion draining, was well. However, patient developed systolic aortic murmur and a chest-X-ray cardiomegaly supposing cardiologic dysfunction. But the normality of cardiac sonography, the ascension of diaphragma and non-specific thoracic sonographic pattern, guided to thoracic MRI. This exploration demonstrated a giant thymolipoma, which was confirmed by the histologic examination of a resected mass. PMID:12708194

Fenniche, Soraya; Maalej, Sonia; Hassene, Hela; Hantous, Saoussen; Belhabib, Dalenda; Bakkari, Sonia; el Mezni, Faouzi; Horchani, Habiba; Megdiche Mohamed, Lamine

2003-01-01

391

Giant mediastinal thymolipoma simulating cardiomegaly.  

PubMed

Thymolipomas are rare anterior mediastinal tumors composed of mature adipose tissue and benign thymic tissue and they may rarely simulate cardiomegaly on chest radiograph. We report an adult male who presented with progressive dyspnea of 2 months' duration. Clinical examination was unremarkable. Chest radiograph showed enlarged cardiac silhouette. Computed tomography of chest revealed a giant anterior mediastinal noncontrast enhancing mass partially wrapping around the heart. A needle biopsy obtained lymphomatous material that was diagnosed as thymolipoma. The tumor was successfully removed en bloc through a median sternotomy. Histopathological examination confirmed thymolipoma. We emphasize the importance of considering mediastinal tumors as a differential diagnosis in patients with progressive dyspnea without any obvious cause and chest radiograph showing enlarged cardiac silhouette. PMID:19782275

Mohan Rao, Prasanna Simha; Moorthy, Nagaraja; Shankarappa, Ravindranath Khandenahalli; Bhat, Prabhavathi; Nanjappa, Manjunath Cholenahalli

2009-10-01

392

The Giant Metrewave Radio Telescope  

NASA Astrophysics Data System (ADS)

The Giant Metrewave Radio Telescope (GMRT) of the National Centre of Radio Astrophysics (NCRA) of the Tata Institute of Fundamental Research (TIFR) at Khodad, India, has been operational in the band 0.2 to 2 metres for the last two and a half years. The system characteristics and performance and recent results from the group will be presented. Details of use over the last six months by scientists from other observatories under the GMRT Time Allocation Committee (GTAC) and future plans will be also be reviewed in this paper. Areas which have been studied include observations made in the GMRT band of neutral hydrogen, nearby galaxies, supernova remnants, the Galactic Centre, pulsars, the Sun and others.

Nityananda, R.

2003-05-01

393

Peripheral giant cell granuloma: a case report.  

PubMed

The peripheral giant cell granuloma is a reactive lesion of the soft tissue of the oral cavity. Clinical appearance ranges from normal tissue coloration to dark red or purplish. These are elevated lesions generally 5-15 mm in diameter. Etiology is considered to be chronic irritation. To decrease the risk of clinical recurrence, treatment is complete excision to include the underlying periosteum. Histologic features of the peripheral giant cell granuloma include multinucleated giant cells with a stroma that may contain osteoblasts, myofibroblasts, macrophages, and Langerhans cells. A case report is presented. PMID:12004669

Breault, L G; Fowler, E B; Wolfgang, M J; Lewis, D M

2000-01-01

394

Helium signature in red giant oscillation spectra  

NASA Astrophysics Data System (ADS)

The space telescopes CoRoT and Kepler have provided seismic data of unprecedent quality on red giants. The oscillation spectrum of these stars have shown a regular pattern called the universal oscillation pattern. These very precise data allow us to study the deviation from this regular pattern. In this work, we measure the modulation component of the radial mode frequency spacing in more than one hundred red giants and attribute the modulation to glitches due to the region of second ionisation of helium. We find a correlation between the location of this zone and the evolutionary status of the red giants. These results brings new constraints on the star interiors.

Vrard, M.; Mosser, B.; Barban, C.

2014-12-01

395

Idiopathic Giant Cell Myocarditis: A Case Report  

PubMed Central

Giant-cell myocarditis is a disease of relatively young, predominantly healthy adults. The patients usually die of heart failure and ventricular arrhythmia unless a cardiac transplantation is performed. We are reporting here an autopsy case of idiopathic giant cell myocarditis with no symptoms in a 27-year old -worker who died suddenly. The purpose of this report was to emphasize that idiopathic giant cell myocarditis was a rare disease and that it could exist in the absence of any symptomatic heart disease. PMID:23205365

Kumari M.K., Kalpana; Mysorekar, Vijaya V.; S., Praveen

2012-01-01

396

Giant Choledochal Calculosis: Surgical Treatment  

PubMed Central

Context: Gallstone disease is one of the most common surgical pathologies. Choledocholithiasis may occur in some of these cases and require surgical intervention. Although there are relatively non-invasive procedures such as endoscopic retrograde cholangiopancreatography (ERCP), this technique is usually unsuccessful in patients with stones larger than 10 mm. In our case, we aimed to report a giant choledochal stone (15 cm × 4.5 cm), which is rare in surgical practice and our treatment with open surgery. Case Report: The patient was a 59-year-old woman. Magnetic resonance cholangiopancreatography (MRCP) had showed a hydropic gallbladder with an excessively dilated CBD and a 110 mm × 41 mm stone. In the operation, an excessively dilated CBD was seen and after choledochotomy and a very large calculus that filled CBD completely. Choledochotomy incision was carried forward and a T-tube choledochostomy with choledochoduodenostomy (CD) was performed. The patient was discharged without any complications on postoperative 8th day. Conclusion: Benign gallstone disease is a multifactorial process, with risk factors such as obesity, hemolytic diseases, diabetes mellitus, and pregnancy. Risk factors for choledocholithiasis are similar to those for gallstone disease. MRCP is a non-invasive technique in detecting choledocholithiasis. The gold standard intervention for CBD stones is ERCP. Stones in CBD may reach very considerable dimensions without causing serious symptoms. The most common symptom is jaundice. During preoperative radiological examination, giant stones may be interfered with malignancies. Surgeons should obey conventional algorithms in diagnosis and open surgery must be kept in mind in earlier stages without being too insistent on endoscopic interventions. PMID:25489567

Bektas, Hasan; Duzkoylu, Yigit; Cakar, Ekrem; Buyukas?k, Kenan; Colak, Sukru

2014-01-01

397

Regulation of hepatic growth.  

PubMed

The liver is a conditional renewal system, which in the adult organism undergoes minimal cell production and/or cell renewal. However, a reduction in liver cell mass, because of either actual cell loss or cell atrophy, evokes a rapid regenerative response tailored to replace the lost tissue. Synthesis of DNA begins as early as 15 h after a two-thirds hepatectomy, and the fact that all the remaining hepatocytes enter DNA synthesis within the next 48 h does indicate they are all potentially proliferative, and it is unlikely that a distinct stem cell compartment exists. The temporal sequelae of events can be best explained by the semisynchronous passage of cells from G0 into the proliferative cycle (see Fig. 2) where they undergo one or more rounds of cell division before decycling back into the proliferatively quiescent G0 state. The age of the animal and its nutritional and hormonal status are all important modifiers of the response, but none of them is critical to the regenerative process. Experiments involving the administration of sera or the transfer of blood between animals strongly favor the existence of humoral regulatory factors; the liver is apparently capable of producing both inhibitory and stimulatory molecules that act by negative and positive feedback mechanisms, respectively, to control tissue homeostasis, whereas other organs, notably the pancreas, are important sources of facilitatory molecules. A chemical mechanism of self inhibition is a very intellectually appealing hypothesis, but at present there is no consistent message as to the identity of the inhibitory molecule, although most studies suggest the target site for its action is the G1-S transition. Unless the whole field is one of multilateral analysis of an artifact, then endogenous growth inhibitors do exist, but the problem now is one of biochemical isolation and characterization. The field compares rather badly with the many success stories in recent years in which new hormones and peptides have been speedily isolated and purified. A reduction in liver size appears to be associated with a decrease in the concentration of an hepatic growth inhibitor and the production and/or unmasking of a stimulatory factor(s) that is also of hepatic origin. Once again, there is little information about the biochemical nature of the principle and much less on its mode of action. We all assume that such stimulators, and for that matter inhibitors as well, act on "restriction points" or "mitosis operons" and so on.(ABSTRACT TRUNCATED AT 400 WORDS) PMID:2426724

Alison, M R

1986-07-01

398

Occult hepatitis B virus infection  

PubMed Central

Occult hepatitis B virus (HBV) infection (OBI) refers to the presence of HBV DNA in the absence of detectable hepatitis B surface antigen. Since OBI was first described in the late 1970s, there has been increasing interest in this topic. The prevalence of OBI varies according to the different endemicity of HBV infection, cohort characteristics, and sensitivity and specificity of the methods used for detection. Although the exact mechanism of OBI has not been proved, intra-hepatic persistence of viral covalently closed circular DNA under the host’s strong immune suppression of HBV replication and gene expression seems to be a cause. OBI has important clinical significance in several conditions. First, OBI can be transmitted through transfusion, organ transplantation including orthotopic liver transplantation, or hemodialysis. Donor screening before blood transfusion, prophylaxis for high-risk organ transplantation recipients, and dialysis-specific infection-control programs should be considered to reduce the risk of transmission. Second, OBI may reactivate and cause acute hepatitis in immunocompromised patients or those receiving chemotherapy. Close HBV DNA monitoring and timely antiviral treatment can prevent HBV reactivation and consequent clinical deterioration. Third, OBI may contribute to the progression of hepatic fibrosis in patients with chronic liver disease including hepatitis C. Finally, OBI seems to be a risk factor for hepatocellular carcinoma by its direct proto-oncogenic effect and by indirectly causing persistent hepatic inflammation and fibrosis. However, this needs further investigation. We review published reports in the literature to gain an overview of the status of OBI and emphasize the clinical importance of OBI. PMID:25544873

Kwak, Min-Sun; Kim, Yoon Jun

2014-01-01

399

How Hepatitis D Virus Can Hinder the Control of Hepatitis B Virus  

E-print Network

How Hepatitis D Virus Can Hinder the Control of Hepatitis B Virus Maria Xiridou1 *, Barbara Borkent) virus is a defective virus that relies on hepatitis B virus (HBV) for transmission; infection of the bond between the two viruses, control measures for HBV may have also affected the spread of hepatitis D

Hulshof, Joost

400

Acute hepatitis associated with autochthonous hepatitis E virus infection--San Antonio, Texas, 2009.  

PubMed

Locally acquired hepatitis E infection is increasingly being observed in industrialized countries. We report 2 cases of autochthonous acute hepatitis E in the United States. Hepatitis E virus genotype 3a related to US-2 and swine hepatitis E virus strains was isolated from one of the patients, indicating potential food-borne or zoonotic transmission. PMID:21896699

Tohme, Rania A; Drobeniuc, Jan; Sanchez, Roger; Heseltine, Gary; Alsip, Bryan; Kamili, Saleem; Hu, Dale J; Guerra, Fernando; Teshale, Eyasu H

2011-10-01

401

Sexual transmission of hepatitis C virus and its relation with hepatitis B virus and HIV  

Microsoft Academic Search

OBJECTIVE--To determine the extent of transmission of hepatitis C virus in sexual partners of intravenous drug misusers and to examine the relation between the prevalences of HIV, hepatitis B virus, and hepatitis C virus infections in homosexual men and intravenous drug misusers and their sexual partners. DESIGN--Serum samples collected between 1984 and 1988 were tested for hepatitis B virus markers

J Tor; J M Llibre; M Carbonell; R Muga; A Ribera; V Soriano; B Clotet; M Sabriá; M Foz

1990-01-01

402

A Virus Similar to Human Hepatitis B Virus Associated with Hepatitis and Hepatoma in Woodchucks  

Microsoft Academic Search

Particles with properties similar to those associated with human hepatitis B were found in serum from woodchucks with chronic hepatitis and hepatocellular carcinoma. It is suggested that woodchuck hepatitis virus is a second member of a novel class of viruses represented by the human hepatitis B virus.

Jesse Summers; Jo Marie Smolec; Robert Snyder

1978-01-01

403

HIGH PREVALENCE OF HEPATITIS B VIRUS AND HEPATITIS D VIRUS IN THE WESTERN BRAZILIAN AMAZON  

Microsoft Academic Search

Severe cases of hepatitis caused by hepatitis B virus (HBV) or hepatitis D virus (HDV) are often seen in the Brazilian Amazon, but there is a paucity of epidemiologic studies on viral hepatitis in this area. Thus, a cross- sectional study to investigate the prevalence of markers for HBV and HDV was performed. Serum samples were collected after participants completed

SEBASTIAO VIANA; RAYMUNDO PARANA; REGINA CELIA MOREIRA; ADRIANA PARISE COMPRI; VANISE MACEDO

2005-01-01

404

HEPATITIS B VACCINE DECLARATION FORM Please submit this completed Hepatitis B Vaccine Form to  

E-print Network

HEPATITIS B VACCINE DECLARATION FORM Please submit this completed Hepatitis B Vaccine Form select and complete one of the applicable sections below: I. "I WOULD LIKE TO RECEIVE THE HEPATITIS B THE HEPATITIS B VACCINE" "I understand that due to my occupational exposure to blood or other potentially

405

Hepatitis C treatment & management.  

PubMed

Combination therapy with pegylated interferon alfa (PEG-IFN alfa) and the nucleoside analogue ribavirin is the current standard of care in patients infected with hepatitis C virus (HCV). Patients with HCV genotype 1 have a much less favorable response to therapy and are treated for 12 months, compared with patients infected with genotypes 2 and 3, in whom a 6-month course of therapy is sufficient. If viremia is present after 6 months, additional therapy has a negligible benefit, and treatment should be stopped in all patients regardless of the viral genotype. With HIV coinfection, all patients with a response to therapy at the end of 6 months should receive an additional 6 months of combination therapy regardless of the genotype. Patients with acute HCV infection should be treated for 6 months. The addition of protease inhibitors to the combination of PEG-IFN alfa and ribavirin is becoming the new standard of care for the treatment of chronic HCV infection. Regimens that include a protease inhibitor significantly improve sustained virologic response rates in patients with genotype 1 HCV infection. PMID:24653754

Andronescu, D; Diaconu, S; Tiuca, N; Purcarea, R M; Andronescu, C I

2014-03-15

406

Hepatitis C Treatment & Management  

PubMed Central

Abstract Combination therapy with pegylated interferon alfa (PEG-IFN alfa) and the nucleoside analogue ribavirin is the current standard of care in patients infected with hepatitis C virus (HCV). Patients with HCV genotype 1 have a much less favorable response to therapy and are treated for 12 months, compared with patients infected with genotypes 2 and 3, in whom a 6-month course of therapy is sufficient. If viremia is present after 6 months, additional therapy has a negligible benefit, and treatment should be stopped in all patients regardless of the viral genotype. With HIV coinfection, all patients with a response to therapy at the end of 6 months should receive an additional 6 months of combination therapy regardless of the genotype. Patients with acute HCV infection should be treated for 6 months. The addition of protease inhibitors to the combination of PEG-IFN alfa and ribavirin is becoming the new standard of care for the treatment of chronic HCV infection. Regimens that include a protease inhibitor significantly improve sustained virologic response rates in patients with genotype 1 HCV infection. PMID:24653754

Andronescu, D; Diaconu, S; Tiuca, N; Purcarea, RM; Andronescu, CI

2014-01-01

407

Giant cell tumor of the talar neck.  

PubMed

We describe a patient with a giant cell tumor in the talar head and neck of the left foot who was diagnosed as having osteochondritis dissecans and treated with arthroscopic drilling in this same location 3 years earlier. Giant cell tumors can be confused with several conditions, including giant cell reparative granulomas, brown tumors, and aneurysmal bone cysts. Giant cell tumors of bone typically occur in the epiphysis of long bones, including the distal femur and proximal tibia. They are uncommonly found in the small bones of the foot or ankle, and talar involvement is rare. Despite this rarity, the radiographic appearance and clinical signs of talar lesions should be considered in the differential diagnosis of nontraumatic conditions in the foot. PMID:17507533

Selek, Hakan; Ozer, Hamza; Turanli, Sacit; Erdem, Ozlem

2007-01-01

408

Tests of the Giant Impact Hypothesis  

NASA Technical Reports Server (NTRS)

The giant impact hypothesis has gained popularity as a means of explaining a volatile-depleted Moon that still has a chemical affinity to the Earth. As Taylor's Axiom decrees, the best models of lunar origin are testable, but this is difficult with the giant impact model. The energy associated with the impact would be sufficient to totally melt and partially vaporize the Earth. And this means that there should he no geological vestige of Barber times. Accordingly, it is important to devise tests that may be used to evaluate the giant impact hypothesis. Three such tests are discussed here. None of these is supportive of the giant impact model, but neither do they disprove it.

Jones, J. H.

1998-01-01

409

Thermoresistance and Giant Magnetoresistance of Magnetorheological Elastomers  

E-print Network

Thermoresistance and Giant Magnetoresistance of Magnetorheological Elastomers N Kchit, P Lancon-mail: bossis@unice.fr Abstract. A new magnetorheological elastomer composite (MRE) was developed to the study of thermoresistance and magnetoresisrance of so called magnetorheological elastomer MRE which

Paris-Sud XI, Université de

410

Mass loss in red giants and supergiants  

NASA Technical Reports Server (NTRS)

The circumstellar envelopes surrounding late-type giants and supergiants were studied using high resolution, photoelectric scans of strong optical resonance lines. A method for extracting the circumstellar from the stellar components of the lines allowed a quantitative determination of the physical conditions in the envelopes and the rates of mass loss at various positions in the red giant region of the HR diagram. The observed strengthening of the circumstellar spectrum with increasing luminosity and later spectral type is probably caused by an increase in the mass of the envelopes. The mass loss rate for individual stars is proportional to the visual luminosity; high rates for the supergiants suggest that mass loss is important in their evolution. The bulk of the mass return to the interstellar medium in the red giant region comes from the normal giants, at a rate comparable to that of planetary nebulae.

Sanner, F.

1975-01-01

411

Lithium Abundance in M3 Red Giant  

NASA Astrophysics Data System (ADS)

We present the abundance of lithium in the red giant star vZ 1050 (SK 291) in the globular cluster M3. A previous survey of giants in the cluster showed that like IV-101, vZ 1050 displays a prominent Li I 6707 Å feature. vZ 1050 lies on the blue side of the red giant branch about 1.3 magnitudes above the level of the horizontal branch, and may be an asymptotic giant branch star. A high resolution spectrum of M3 vZ1050 was obtained with the ARC 3.5m telescope and the ARC Echelle Spectrograph (ARCES). Atmospheric parameters were determined using Fe I and Fe II lines from the spectrum using the MOOG spectral analysis program, and the lithium abundance was determined using spectrum synthesis.

Givens, Rashad; Pilachowski, Catherine A.

2015-01-01

412

Ages of Red Giants from Asteroseismology  

NASA Astrophysics Data System (ADS)

Red giant stars are a fascinating laboratory to test stellar evolution, and with tools from asteroseismology we can gain a unique perspective into their deep interiors. Given the fast variation of oscillation-mode frequencies as function of evolutionary state along the red giant phase, we are able to determine an age. Stars in eclipsing binary systems also present us with the ability to precisely determine stellar properties, such as mass and radius. We present an initial analysis of the oscillations for several binary systems, all of which include a red giant and an F-type companion. We compare the modes that we observe in the red giant star to those expected from a stellar model. The models are created using the MESA stellar evolution code. Parameters for the stellar model come from binary light curve modeling and analysis of high resolution spectra of the systems.

McKeever, Jean; Gaulme, Patrick; Rawls, Meredith L.; Jackiewicz, Jason

2015-01-01

413

Genetics Home Reference: Giant congenital melanocytic nevus  

MedlinePLUS

... Patients and Families Resources for Health Professionals What glossary definitions help with understanding giant congenital melanocytic nevus? ... many other terms in the Genetics Home Reference Glossary . See also Understanding Medical Terminology . References (7 links) ...

414

Granuloma with langhans giant cells: An overview  

PubMed Central

Granuloma formation with multinucleated giant cells is seen in numerous diseases. A granuloma is a focus of chronic inflammation consisting of a microscopic aggregation of macrophages surrounded by a collar of lymphocytes and plasma cells. In this article, we present a case of granuloma formation with multiple Langhans giant cells along with an overview of the differential diagnoses, which include mycobacterium diseases, other bacterial infections, fungal infections, protozoal infections, and other granulomatous diseases. PMID:24574664

Kumar, S Nalin; Prasad, T Srinivasa; Narayan, P Anantha; Muruganandhan, J

2013-01-01

415

Giant rhinophyma: Excision with coblation assisted surgery  

PubMed Central

An 83-year-old man presented with an unusually severe case of rhinophyma. Giant rhinopyhma is very rare in literature. The giant lesion was widely excised using sharp surgical incision and coblation assisted surgery. Using direct coblation to the nasal dorsum may cause edema in the surrounding tissue. There was minimal edema in surrounding tissue using this technique. A full thickness-skin graft was applied after excision. Cosmetic and functional postoperative results were satisfactory.

Sahin, Caner; Turker, Mesut; Celasun, Bulent

2014-01-01

416

Oral manifestations of giant cell arteritis  

Microsoft Academic Search

Summary  Giant cell arteritis is a systemic disease of unknown origin characterized by vasculitis of mediumsized and larger vessels,\\u000a found mainly in elderly women. It presents with a variety of symptoms, including temporal pain and tenderness, headache, and\\u000a neuro-ophthalmic features. This report describes a case of giant cell arteritis in a 78-year-old woman with a large ulceration\\u000a on the right side

J. E. van der Wal; I. van der Waal

1997-01-01

417

Large-Spin Expansions of Giant Magnons  

E-print Network

This is a talk given at the Workshop on Quantum Fields and Strings of the 2014 Corfu Summer Institute. We discuss how giant magnons emerge in the context of AdS5/CFT4 correspondence as the gravity duals of N = 4 super Yang-Mills magnon excitations. Then we present a new analytic expression for the dispersion relation of classical finite-size giant magnons with Lambert's W-function.

Linardopoulos, Georgios

2015-01-01

418

Giant multi-loculated apocrine hidrocystomas.  

PubMed

Giant, multi-loculated hidrocystomas represent a rare variant of the common, benign hidrocystoma. Hidrocystomas are generally 1-3 mm and rarely exceed 10 mm. We describe a case of giant multi-loculated hidrocystomas 1-2 cm in size that were located near both upper and lower eyelids. Multiple modalities have been used to treat hidrocystomas, including excision, pulsed-dye laser, electrodesiccation, curettage, tricholoracetic acid, botulinum toxin, and anticholinergics. PMID:21163167

Vashi, Neelam; Mandal, Rajni

2010-01-01

419

Giant cell interstitial pneumonia associated with nitrofurantoin.  

PubMed

A case of giant cell interstitial pneumonia (GIF) that occurred in association with exposure to nitrofurantoin is presented. While the diagnosis of GIP is confirmed by histopathology, this diagnosis can be supported by the findings of bizarre multinucleated giant cells (MGC), elevated T lymphocytes, and a low T lymphocyte helper/suppressor ratio in the bronchoalveolar lavage fluid (BALF). Recognition of GIP as a rare manifestation of nitrofurantoin toxicity is important because prompt therapy may be associated with a favorable outcome. PMID:16902839

Hargett, Charles William; Sporn, Thomas A; Roggli, Victor L; Hollingsworth, John W

2006-01-01

420

Giant Cell Interstitial Pneumonia Associated with Nitrofurantoin  

Microsoft Academic Search

A case of giant cell interstitial pneumonia (GIF) that occurred in association with exposure to nitrofurantoin is presented.\\u000a While the diagnosis of GIP is confirmed by histopathology, this diagnosis can be supported by the findings of bizarre multinucleated\\u000a giant cells (MGC), elevated T lymphocytes, and a low T lymphocyte helper\\/suppressor ratio in the bronchoalveolar lavage fluid\\u000a (BALF). Recognition of GIP

Charles William Hargett; Thomas A. Sporn; Victor L. Roggli; John W. Hollingsworth

2006-01-01

421

Ontogeny of rat hepatic adrenoceptors  

SciTech Connect

Hepatic alpha-1, alpha-2 and beta-2 adrenoceptors were characterized during development of the rat through Scatchard analysis of (3H)prazosin, (3H)rauwolscine and (125I)pindolol binding to liver membrane preparations. Major changes in adrenoceptor numbers occur shortly before birth at weaning. The fetal rat liver is characterized by a large number of alpha-2 adrenoceptors, which falls 10-fold by birth. The number of hepatic beta-2 adrenoceptors decreases gradually during development, and is lower at all times than the number of alpha-1 and alpha-2 adrenoceptors. The developmental profile of the hepatic alpha-1 adrenoceptor is biphasic: there is a 2 to 3-fold fall in alpha-1 adrenoceptor number at birth and a 3- to 5-fold rise at weaning. While absolute numbers of alpha-1 and beta-2 adrenoceptors do not correlate precisely with reported actions of epinephrine and norepinephrine on hepatic metabolism during ontogeny, the increasing ratio of alpha-1/beta-2 hepatic adrenoceptors may contribute to the conversion from predominantly beta effects of catecholamines reported in fetal and suckling rat liver to the predominantly alpha-1 effects that are well documented in the adult male rat.

McMillian, M.K.; Schanberg, S.M.; Kuhn, C.M.

1983-10-01

422

Parvovirus B19 Associated Hepatitis  

PubMed Central

Parvovirus B19 infection can present with myriads of clinical diseases and syndromes; liver manifestations and hepatitis are examples of them. Parvovirus B19 hepatitis associated aplastic anemia and its coinfection with other hepatotropic viruses are relatively underrecognized, and there is sufficient evidence in the literature suggesting that B19 infections can cause a spectrum of liver diseases from elevation of transaminases to acute hepatitis to fulminant liver failure and even chronic hepatitis. It can also cause fatal macrophage activation syndrome and fibrosing cholestatic hepatitis. Parvovirus B19 is an erythrovirus that can only be replicate in pronormoblasts and hepatocytes, and other cells which have globosides and glycosphingolipids in their membrane can also be affected by direct virus injury due to nonstructural protein 1 persistence and indirectly by immune mediated injury. The virus infection is suspected in bone marrow aspiration in cases with sudden drop of hemoglobin and onset of transient aplastic anemia in immunosuppressed or immunocompetent patients and is confirmed either by IgM and IgG positive serology, PCR analysis, and in situ hybridization in biopsy specimens or by application of both. There is no specific treatment for parvovirus B19 related liver diseases, but triple therapy regimen may be effective consisting of immunoglobulin, dehydrohydrocortisone, and cyclosporine. PMID:24232179

Bihari, Chhagan; Rastogi, Archana; Saxena, Priyanka; Rangegowda, Devraj; Chowdhury, Ashok; Gupta, Nalini; Sarin, Shiv Kumar

2013-01-01

423

Hepatitis B surface antigen in late hepatitis B infection.  

PubMed

Hepatitis B surface antigen (HBsAg) levels are used to evaluate and monitor clinical phases of chronic hepatitis B infection but their clinical significance is unclear in the late complications, cirrhosis of the liver and hepatocellular carcinoma. This study aimed to evaluate HBsAg levels across the whole natural history of hepatitis B virus infection, including late complications. This retrospective, cross-sectional study enrolled 838 treatment-naive patients diagnosed with chronic hepatitis B infection at First Affiliated Hospital of Fujian Medical University between 2009 and 2012. Patients were classified into six groups: immunotolerance, immunoclearance, low replicative, negative hepatitis e (HBeAg) phases, liver cirrhosis, and hepatocellular carcinoma. Main outcome measures were serum HBsAg, HBeAg, HBV DNA, total bilirubin, albumin, alanine and aspartate aminotransferase, and quantitative correlation of HBsAg with HBV DNA. HBsAg levels declined significantly between clinical phases of infection (all P?hepatitis B infection phases, decreasing progressively from chronic infection to cirrhosis and hepatocellular carcinoma. Significant correlations are found between serum HBsAg and HBV DNA. J. Med. Virol. 87:380-387, 2015. © 2014 Wiley Periodicals, Inc. PMID:25604455

Zeng, Da-Wu; Zhu, Yue-Yong; Huang, Qian; Zhang, Jie-Min; Wu, Yin-Lian; Dong, Jing; Jiang, Jia-Ji; Liu, Yu-Rui

2015-03-01

424

Formation of Giant Planets and Brown Dwarves  

NASA Technical Reports Server (NTRS)

According to the prevailing core instability model, giant planets begin their growth by the accumulation of small solid bodies, as do terrestrial planets. However, unlike terrestrial planets, the growing giant planet cores become massive enough that they are able to accumulate substantial amounts of gas before the protoplanetary disk dissipates. Models predict that rocky planets should form in orbit about most stars. It is uncertain whether or not gas giant planet formation is common, because most protoplanetary disks may dissipate before solid planetary cores can grow large enough to gravitationally trap substantial quantities of gas. Ongoing theoretical modeling of accretion of giant planet atmospheres, as well as observations of protoplanetary disks, will help decide this issue. Observations of extrasolar planets around main sequence stars can only provide a lower limit on giant planet formation frequency . This is because after giant planets form, gravitational interactions with material within the protoplanetary disk may cause them to migrat inwards and be lost to the central star. The core instability model can only produce planets greater than a few jovian masses within protoplanetary disks that are more viscous than most such disks are believed to be. Thus, few brown dwarves (objects massive enough to undergo substantial deuterium fusion, estimated to occur above approximately 13 jovian masses) are likely to be formed in this manner. Most brown dwarves, as well as an unknown number of free-floating objects of planetary mass, are probably formed as are stars, by the collapse of extended gas/dust clouds into more compact objects.

Lissauer, Jack J.

2003-01-01

425

Testing planet formation theories with Giant stars  

E-print Network

Planet searches around evolved giant stars are bringing new insights to planet formation theories by virtue of the broader stellar mass range of the host stars compared to the solar-type stars that have been the subject of most current planet searches programs. These searches among giant stars are producing extremely interesting results. Contrary to main sequence stars planet-hosting giants do not show a tendency of being more metal rich. Even if limited, the statistics also suggest a higher frequency of giant planets (at least 10 %) that are more massive compared to solar-type main sequence stars. The interpretation of these results is not straightforward. We propose that the lack of a metallicity-planet connection among giant stars is due to pollution of the star while on the main sequence, followed by dilution during the giant phase. We also suggest that the higher mass and frequency of the planets are due to the higher stellar mass. Even if these results do not favor a specific formation scenario, they suggest that planetary formation might be more complex than what has been proposed so far, perhaps with two mechanisms at work and one or the other dominating according to the stellar mass. We finally stress as the detailed study of the host stars and of the parent sample is essential to derive firm conclusions.

Luca Pasquini; M. P. Doellinger; A. Hatzes; J. Setiawan; L. Girardi; L. da Silva; J. R. de Medeiros

2008-01-22

426

Hepatitis GB virus-C\\/hepatitis G virus infection in liver disease  

Microsoft Academic Search

Hepatitis GB virus-C (HGBV-C)\\/hepatitis G virus (HGV) infection was investigated in 106 children with liver disease (54 boys and 52 girls, mean age 7.3 years); 12 with chronic hepatitis C virus infection, 29 with positive hepatitis B surface antigen, nine with idiopathic fulminant hepatic failure, seven with graft dysfunction after liver transplantation associated with autoimmune features, 20 with cryptogenic liver

Ikuo Nagata; Nikos Tzampouras; Shilpa Chokshi; Nikolai V Naoumov; Paul Cheeseman; Heather M Smith; Alastair J Baker; Roger Williams; Giorgina Mieli-Vergani

1997-01-01

427

Hepatic toxicity resulting from cancer treatment  

Microsoft Academic Search

Radiation-induced liver disease (RILD), often called radiation hepatitis, is a syndrome characterized by the development of anicteric ascites approximately 2 weeks to 4 months after hepatic irradiation. There has been a renewed interest in hepatic irradiation because of two significant advances in cancer treatment: three dimensional radiation therapy treatment planning and bone marrow transplantation using total body irradiation. RILD resulting

Theodore S. Lawrence; John M. Robertson; Mitchell S. Anscher; Randy L. Jirtle; William D. Ensminger; Luis F. Fajardo

1995-01-01

428

77 FR 45895 - World Hepatitis Day, 2012  

Federal Register 2010, 2011, 2012, 2013, 2014

...Proclamation 8845 of July 27, 2012 World Hepatitis Day, 2012 By the President of the United...in twelve people is living with viral hepatitis--a disease that threatens the health...of their infection status. On World Hepatitis Day, we call attention to this...

2012-08-02

429

76 FR 46181 - World Hepatitis Day, 2011  

Federal Register 2010, 2011, 2012, 2013, 2014

...Proclamation 8696--World Hepatitis Day, 2011 Presidential Documents Federal...Proclamation 8696 of July 27, 2011 World Hepatitis Day, 2011 By the President of the United...millions of Americans are living with viral hepatitis. As many as three-fourths of...

2011-08-01

430

Hepatitis C, stigma and cure  

PubMed Central

The infection with hepatitis C virus (HCV) is one of the most important global chronic viral infections worldwide. It is estimated to affect around 3% of the world population, about 170-200 million people. Great part of the infections are asymptomatic, the patient can be a chronic carrier for decades without knowing it. The most severe consequences of the chronic infection are liver cirrhosis and hepatocellular carcinoma, which appears in 20%-40% of the patients, leading to hepatic failure and death. The HCV was discovered 25 years ago in 1989, is a RNA virus and classified by the World Health Organization as an oncogenic one. Hepatocellular carcinoma is one of the most important cancers, the fifth worldwide in terms of mortality. It has been increasing in the Ocidental world, mainly due to chronic hepatitis C. Hepatitis C is not only a liver disease and a cause of cirrhosis, but also a mental, psychological, familiar, and social disease. The stigma that the infected person sometimes carries is tremendous having multiple consequences. The main cause is lack of adequate information, even in the health professionals setting. But, besides the “drama” of being infected, health professionals, family, society and the infected patients, must be aware of the chance of real cure and total and definitive elimination of the virus. The treatment for hepatitis C has begun in the last 80´s with a percentage of cure of 6%. Step by step the efficacy of the therapy for hepatitis C is rapidly increasing and nowadays with the very new medications, the so called Direct Antiviral Agents-DAAs of new generation, is around 80%-90%. PMID:24187444

Marinho, Rui Tato; Barreira, David Pires

2013-01-01

431

Hepatitis C and liver transplantation  

NASA Astrophysics Data System (ADS)

Liver transplantation is a life-saving therapy to correct liver failure, portal hypertension and hepatocellular carcinoma arising from hepatitis C infection. But despite the successful use of living donors and improvements in immunosuppression and antiviral therapy, organ demand continues to outstrip supply and recurrent hepatitis C with accelerated progression to cirrhosis of the graft is a frequent cause of graft loss and the need for retransplantation. Appropriate selection of candidates and timing of transplantation, coupled with better pre- and post-transplant antiviral therapy, are needed to improve outcomes.

Brown, Robert S.

2005-08-01

432

Chronic hepatitis B in hepatocarcinogenesis  

PubMed Central

Hepatocellular carcinoma (HCC) is the fifth most common cancer in the world, and has a wide geographical variation. Eighty per cent of HCC is attributed to hepatitis B virus (HBV). The predominant carcinogenic mechanism of HBV associated HCC is through the process of liver cirrhosis, but direct oncogenic effects of HBV may also contribute. Prevention of HBV infections as well as effective treatment of chronic hepatitis B is still needed for the global control of HBV associated HCC. Continued investigation of the mechanisms of hepatocarcinogenesis will refine our current understanding of the molecular and cellular basis for neoplastic transformation in the liver. PMID:16891440

Park, N H; Song, I H; Chung, Y?H

2006-01-01

433

Giant Electrocaloric Effect Around Tc  

NASA Astrophysics Data System (ADS)

We use molecular dynamics with a first-principles-based shell model potential to study the electrocaloric effect (ECE) in lithium niobate, LiNbO3, and find a giant electrocaloric effect along a line passing through the ferroelectric transition. With an applied electric field, a line of maximum ECE passes through the zero field ferroelectric transition, continuing along a Widom line at high temperatures with increasing fields, and along the instability that leads to homogeneous ferroelectric switching below Tc with an applied field antiparallel to the spontaneous polarization. This line is defined as the minimum in the inverse capacitance under an applied electric field. We investigate the effects of pressure, temperature and an applied electric field on the ECE. The behavior we observe in LiNbO3 should generally apply to ferroelectrics; we therefore suggest that the operating temperature for refrigeration and energy scavenging applications should be above the ferroelectric transition region to obtain a large electrocaloric response. The relationship between Tc, the Widom line, and homogeneous switching should be universal among ferroelectrics, relaxors, multiferroics, and the same behavior should be found under applied magnetic fields in ferromagnets.

Rose, Maimon C.; Cohen, R. E.

2012-11-01

434

A giant thunderstorm on Saturn.  

PubMed

Lightning discharges in Saturn's atmosphere emit radio waves with intensities about 10,000 times stronger than those of their terrestrial counterparts. These radio waves are the characteristic features of lightning from thunderstorms on Saturn, which last for days to months. Convective storms about 2,000 kilometres in size have been observed in recent years at planetocentric latitude 35° south (corresponding to a planetographic latitude of 41° south). Here we report observations of a giant thunderstorm at planetocentric latitude 35° north that reached a latitudinal extension of 10,000 kilometres-comparable in size to a 'Great White Spot'-about three weeks after it started in early December 2010. The visible plume consists of high-altitude clouds that overshoot the outermost ammonia cloud layer owing to strong vertical convection, as is typical for thunderstorms. The flash rates of this storm are about an order of magnitude higher than previous ones, and peak rates larger than ten per second were recorded. This main storm developed an elongated eastward tail with additional but weaker storm cells that wrapped around the whole planet by February 2011. Unlike storms on Earth, the total power of this storm is comparable to Saturn's total emitted power. The appearance of such storms in the northern hemisphere could be related to the change of seasons, given that Saturn experienced vernal equinox in August 2009. PMID:21734705

Fischer, G; Kurth, W S; Gurnett, D A; Zarka, P; Dyudina, U A; Ingersoll, A P; Ewald, S P; Porco, C C; Wesley, A; Go, C; Delcroix, M

2011-07-01

435

Giant Intradiploic Angiolipoma of the skull. Report of the first case with MR and histopathological characteristics reported in the literature and a review  

PubMed Central

Background: Intraosseous Angiolipoma of the skull bone (IOAL) is a very rare bony lesion of the calvarium. This lesion occurs most commonly in the soft, subcutaneous tissue of the trunk. Only a single case of angiolipoma of the skull has been previously reported. The authors report the first case of giant IOAL of the calvarium evaluated by 3D CTS, MRI and full histopathological staining in a young lady treated surgically and with 23 months of follow up. Case Description: A 41-year-old female was admitted because of a prominent bulging on her right parietal region. Three dimensional CT and CT angiographic reconstruction of the cranium elucidated the geographical pattern of the lesion. MRI revealed a huge intraosseous right frontotemporoparietooccipital expansile lesion, nonhomogeneous but mostly hyperintense, in T1W images. In T2W images, the lesion was nonhomogeneously hyperintense and trabeculated with no perilesional edema. In the FLAIR-images, the lesion was trabeculated and nonhomogeneously hypointense. The lesion was excised totally followed by skull reconstruction and no recurrence after 23 months. Conclusion: We hypothesize that the possible pathogenesis of IOAL may be a kind of mutation or dedifferentiation of either a primary intradiploic hemangioma or lipoma changing its growth pattern with possibly more aggressive behavior. PMID:24818057

Amirjamshidi, Abbas; Ghasemi, Babak; Abbasioun, Kazem

2014-01-01

436

Occult Hepatitis C Virus Infection in Patients With Autoimmune Hepatitis  

PubMed Central

Background: Occult hepatitis C virus infection (OCI) is recognized by finding hepatitis C virus (HCV) RNA in hepatocytes without detectable anti-HCV antibodies and viral RNA in plasma. Autoimmune hepatitis (AIH) is a chronic and generally progressive disease without exactly-identified etiology. Objectives: This study aimed to determine the prevalence of OCI among patients with AIH and to evaluate the tests used to rule out HCV infection in diagnosing AIH. Patients and Methods: Between July 2012 to February 2013, 35 Iranian patients with AIH who attended Tehran Hepatitis Center were investigated. For identifying OCI, detection of HCV RNA in both ultracentrifuged serum samples and peripheral blood mononuclear cells (PBMCs) was used. Data analysis was performed using SPSS. Results: Six males and 29 females with mean disease duration of 77.1 ± 39.5 month and mean age of 43.62 ± 12.67 years were investigated. All cases were negative for anti-HCV antibody and we could not find any HCV RNA in ultracentrifuged serum samples and PBMCs. Conclusions: With our laboratory diagnostic method, it seems that there are no cases of OCI in patients with AIH. However, we recommend further studies with more samples and more precise laboratory method. PMID:25337141

Rezaee Zavareh, Mohammad Saeid; Alavian, Seyed Moayed; Karimisari, Hamidreza; Shafiei, Mostafa; Saiedi Hosseini, Seyed Yasser

2014-01-01

437

Fractional carbon dioxide laser-assisted drug delivery of topical timolol solution for the treatment of deep infantile hemangioma: a pilot study.  

PubMed

Infantile hemangiomas (IHs) are benign vascular tumors of infancy. Topical timolol has recently been reported to be an effective treatment for superficial IHs, although it failed to have an effect on deep IHs. This prospective study was aimed at evaluating the feasibility of ablative fractional laser-assisted drug delivery for enhancing topical timolol permeation into deep IHs. Nine patients ages 1 to 6 months with deep IHs were enrolled. A fractional carbon dioxide (CO2 ) laser system was applied to the skin surface of deep IHs using the DeepFx mode (25-30 mJ/pulse, 5% density, single pulse) at 1-week intervals. Topical timolol maleate 0.5% ophthalmic solution was applied under occlusion for 30 minutes four to five times per day for an average treatment duration of 14.2 weeks. Clinical improvement was evaluated according to a global score and the Hemangioma Activity Score (HAS). Four patients (44.4%) demonstrated excellent regression, four (44.4%) showed good response, and one (11.1%) experienced moderate regression. The HAS declined from 4.1 ± 0.7 at baseline to 1.7 ± 0.7 at 1 week (p < 0.001) and 1.4 ± 0.7 at 3 months (p = 0.03) after the last treatment procedure. Plasma timolol concentration was not detected in any of the patients after the first administration of topical timolol. No systemic complication or skin side effects were observed in any of the patients. Ablative fractional laser-assisted transdermal delivery of topical timolol is a safe and effective method for the treatment of deep IHs. PMID:24602019

Ma, Gang; Wu, Pinru; Lin, Xiaoxi; Chen, Hui; Hu, Xiaojie; Jin, Yunbo; Qiu, Yajing

2014-01-01

438

Giant cell tumor arising from anterior arc of the rib.  

PubMed

A primary giant cell tumor of the rib is very rare. The most common site of a giant cell tumor arising from the rib is the posterior arc. A giant cell tumor arising from the anterior arc of the rib is extremely rare. The treatment of a giant cell tumor of the rib is not well defined. Generally, a complete surgical resection is performed in a patient with a primary giant cell tumor of the rib. We report a case of a giant cell tumor arising from the anterior arc of the rib that was treated with a wide excision and chest wall reconstruction. PMID:24175276

Heo, Woon; Kang, Do Kyun; Min, Ho-Ki; Jun, Hee Jae; Hwang, Youn-Ho

2013-10-01

439

Episodic lithium production by extra-mixing in red giants  

E-print Network

The recent discovery of low-mass red giants with enhanced atmospherical Li abundance in galactic low-metallicity stellar clusters adds to the mysterious phenomenon of the Li-rich giants. We propose a combined scenario for the Li-enrichment: engulfing a giant planet (or brown dwarf) by a red giant (external source) activates inside the giant the "7Be-mechanism" producing Li internally. This episodical Li-production can happen at any time on the red giant branch and is naturally followed by Li-depletion as is observed. Limitations of our scenario are discussed as well.

P. A. Denissenkov; A. Weiss

2000-05-17

440

Rapid Rotators among APOGEE Red Giants  

NASA Astrophysics Data System (ADS)

The Apache Point Galactic Evolution Experiment (APOGEE) is a part of the SDSS-III survey. APOGEE is a high-resolution (R 22,500) multi-fiber near-infrared (1.5-1.7 mu) spectroscopic survey of 100,000 candidate stars selected from all populations of the Milky Way. The majority of the APOGEE targets are expected to be red giants. Past studies have shown that a small fraction (1-2%) of red giant stars shows rather high projected rotational velocities (vsini > 10 km/s), whereas most of the red giants rotates slowly (vsini 2 km/s). The unusual rapid rotation for this type of giants may indicate that they experience either a rare and poorly understood stage of evolution, or swallow low-massive companions (such as brown dwarfs or planets). Due to the combination of high resolution and high signal-to-noise ratio (SNR), the APOGEE provides us with a unique possibility to study the stellar rotation for a large sample of cool stars, and particularly to uncover the largest sample of rapidly rotating red giants to date. Even conservative estimates of the fraction of rapidly rotating giants imply that we can increase the number of known rapid rotators by almost an order of magnitude. For the first half of a year of science operations, which started in September 2011, APOGEE has produced spectra of more than 20,000 unique science targets. These single-visit spectra have lower than final SNR, and they will be improved after two more visits to the same target during the next two years of observations to reach the program SNR. In this paper we present the first sample of rapidly rotating red giants selected from reduced APOGEE spectra presently available. We test different approaches to the estimation of the spectral line broadening and rotational velocity.

Bizyaev, Dmitry; Carlberg, J. K.; Nidever, D. L.; Majewski, S. R.; Shetrone, M. D.; Smith, V. V.; Patterson, R. J.; Cunha, K.; Holtzman, J. A.; O'Connell, R. W.; Pan, K.

2012-05-01

441

Hepatitis B Genotypes in Iran  

PubMed Central

Hepatitis B virus (HBV) infection is a public health problem as a cause of liver diseases including hepatocellular carcinoma and cirrhosis. It is estimated that 350 million people live with chronic infection and about one million people die every year from complication of this chronic disease in the world. So far, ten HBV genotypes (A-J) has been identified which show a geographical distribution. Throughout the world, carrier variability rate for hepatitis B infection is estimated to be 0.1% to 20%, with regions classified as having low endemicity (<2%), intermediate endemicity (2-7%) and high endemicity (>8%). The prevalence of hepatitis B infection is estimated at 2 to 7 percent In Iran. After HBV vaccination program the prevalence of hepatitis B infection has been reported less than 2%, so Iran can be considered one of the countries with low HBV infection endemicity. In Iran several studies were shown that the only genotype of HBV(100%)was found genotype D as the prominent type in some provinces, but some studies reported genotype B(5%)as well as genotype D(95%).The distribution of HBV genotypes may guide us in determining disease burden, prognosis and antiviral responses. So, it is important to know the epidemiologically of HBV genotyping as well. PMID:24944540

Haghshenas, Mohammad Reza; Arabi, Mohsen; Mousavi, Tahoora

2014-01-01

442

Optimal management of alcoholic hepatitis.  

PubMed

Alcoholic hepatitis, a clinical syndrome among people with chronic and active alcohol abuse presents with with jaundice and liver failure with or without hepatic encephalopathy. In patients with severe episode, this condition has a potential for 40-50% mortality within a month of presentation. Corticosteroids and pentoxifylline, only available current treatment options provide only about 50% survival benefit. Response to corticosteroids can only be assessed at 1 week of initiation of these drugs using Lille score or documentation of improvement in bilirubin levels. Requirement of minimum 6 months abstinence for liver transplantation cannot be met for alcoholic hepatitis patients who fail to respond to steroids. Emerging data on the benefit of liver transplantation for select patients with first episode of severe AH with non-response to steroids are encouraging. There remains an unmet need for studies assessing newer therapeutic targets and drugs and for optimizing the currently available treatment options. In this regard, decision to promote clinical and translational research by the National Institute of Alcohol Abuse and Alcoholism will be helpful in improving survival of patients with alcoholic hepatitis. PMID:24632766

Raff, E; Singal, A K

2014-03-01

443

An MHD Model for Magnetar Giant Flares  

NASA Astrophysics Data System (ADS)

Giant flares on soft gamma-ray repeaters that are thought to take place on magnetars release enormous energy in a short time interval. Their power can be explained by catastrophic instabilities occurring in the magnetic field configuration and the subsequent magnetic reconnection. By analogy with the coronal mass ejection events on the Sun, we develop a theoretical model via an analytic approach for magnetar giant flares. In this model, the rotation and/or displacement of the crust causes the field to twist and deform, leading to flux rope formation in the magnetosphere and energy accumulation in the related configuration. When the energy and helicity stored in the configuration reach a threshold, the system loses its equilibrium, the flux rope is ejected outward in a catastrophic way, and magnetic reconnection helps the catastrophe develop to a plausible eruption. By taking SGR 1806-20 as an example, we calculate the free magnetic energy released in such an eruptive process and find that it is more than 1047 erg, which is enough to power a giant flare. The released free magnetic energy is converted into radiative energy, kinetic energy, and gravitational energy of the flux rope. We calculated the light curves of the eruptive processes for the giant flares of SGR 1806-20, SGR 0526-66, and SGR 1900+14, and compared them with the observational data. The calculated light curves are in good agreement with the observed light curves of giant flares.

Meng, Y.; Lin, J.; Zhang, L.; Reeves, K. K.; Zhang, Q. S.; Yuan, F.

2014-04-01

444

Giant components in directed multiplex networks  

NASA Astrophysics Data System (ADS)

We describe the complex global structure of giant components in directed multiplex networks that generalizes the well-known bow-tie structure, generic for ordinary directed networks. By definition, a directed multiplex network contains vertices of one type and directed edges of m different types. In directed multiplex networks, we distinguish a set of different giant components based on the existence of directed paths of different types between their vertices such that for each type of edges, the paths run entirely through only edges of that type. If, in particular, m =2 , we define a strongly viable component as a set of vertices in which for each type of edges each two vertices are interconnected by at least two directed paths in both directions, running through the edges of only this type. We show that in this case, a directed multiplex network contains in total nine different giant components including the strongly viable component. In general, the total number of giant components is 3m. For uncorrelated directed multiplex networks, we obtain exactly the size and the emergence point of the strongly viable component and estimate the sizes of other giant components.

Azimi-Tafreshi, N.; Dorogovtsev, S. N.; Mendes, J. F. F.

2014-11-01

445

Natural history of hepatitis C.  

PubMed

There has long been evidence that hepatitis C can lead to persistent infection in a high proportion of infected individuals, and can progress to chronic liver disease, cirrhosis and hepatocellular carcinoma (HCC). The transition from acute to chronic hepatitis C is usually sub-clinical. Accurate studies of the time course for clearance of acute hepatitis C are difficult to carry out because of the silent onset of the acute disease. The likelihood of spontaneous HCV resolution is associated with several genetic factors, including IL28B inheritance and the DQB1*0301 allele of the major histocompatibility complex class II. Most data suggest that resolution in the acute phase without progression to chronic disease is not accompanied by significant disease, but minor histological lesions have been observed in anti-HCV positive, HCV RNA negative individuals. The risk of reinfection remains a possibility after clearance of acute hepatitis C. High rates of sexually-transmitted infection are being reported in HIV positive men who have sex with men (MSM). Chronic infection with HCV is the leading cause of end-stage liver disease, hepatocellular carcinoma (HCC) and liver related death in the Western world. The natural history of the chronic disease remains incompletely defined. It is generally a slowly progressive disease characterized by persistent hepatic inflammation, leading to the development of cirrhosis in approximately 10-20% of patients over 20-30 years of HCV infection. However, the published data indicate varying progression rates to cirrhosis. Overall, once cirrhosis has developed there is a 1-5% annual risk of HCC and a 3-6% annual risk of hepatic decompensation. Following an episode of decompensation the risk of death in the following year is between 15% and 20%. The high number of chronically infected individuals, the burden of disease, and the absence of a vaccine indicates that treatment will form part of the disease control but the impact, effectiveness and outcomes of treatment in various groups remain uncertain. Several studies and meta-analysis have concluded that eradication of HCV with antiviral therapy reduces the risk of HCC in patients with chronic hepatitis C, independent of fibrosis stage, but the risk is not eliminated. PMID:25443346

Westbrook, Rachel H; Dusheiko, Geoffrey

2014-11-01

446

Electrodynamics on Extrasolar Giant Planets  

NASA Astrophysics Data System (ADS)

Strong ionization on close-in extrasolar giant planets (EGPs) suggests that their atmospheres may be affected by ion drag and resistive heating arising from wind-driven electrodynamics. Recent models of ion drag on these planets, however, are based on thermal ionization only and do not include the upper atmosphere above the 1 mbar level. These models are also based on simplified equations of resistive magnetohydrodynamics that are not always valid in extrasolar planet atmospheres. We show that photoionization dominates over thermal ionization over much of the dayside atmosphere above the 100 mbar level, creating an upper ionosphere dominated by ionization of H and He and a lower ionosphere dominated by ionization of metals such as Na, K, and Mg. The resulting dayside electron densities on close-in exoplanets are higher than those encountered in any planetary ionosphere of the solar system, and the conductivities are comparable to the chromosphere of the Sun. Based on these results and assumed magnetic fields, we constrain the conductivity regimes on close-in EGPs and use a generalized Ohm's law to study the basic effects of electrodynamics in their atmospheres. We find that ion drag is important above the 10 mbar level where it can also significantly alter the energy balance through resistive heating. Due to frequent collisions of the electrons and ions with the neutral atmosphere, however, ion drag is largely negligible in the lower atmosphere below the 10 mbar level for a reasonable range of planetary magnetic moments. We find that the atmospheric conductivity decreases by several orders of magnitude in the night side of tidally locked planets, leading to a potentially interesting large-scale dichotomy in electrodynamics between the day and night sides. A combined approach that relies on UV observations of the upper atmosphere, phase curve and Doppler measurements of global dynamics, and visual transit observations to probe the alkali metals can potentially be used to constrain electrodynamics in the future.

Koskinen, T. T.; Yelle, R. V.; Lavvas, P.; Y-K. Cho, J.

2014-11-01

447

Eltrombopag in chronic hepatitis C  

PubMed Central

Chronic hepatitis C is a public health problem worldwide. Unfortunately, not all patients may benefit from antiviral therapy due to thrombocytopenia. Its causes are represented by portal hypertension and platelet sequestration in the spleen, decreased serum levels or activity of thrombopoietin, the bone marrow suppression induced by hepatitis C virus and a possible adverse effect of interferon. Thrombopoietin receptor analogs may contribute to increase platelet counts in these patients. Eltrombopag binds to another region of the thrombopoietin receptor compared to endogenous thrombopoietin and stimulates the proliferation and maturation of megakaryocytes and the platelet production in a dose-dependent manner. Eltrombopag has proven its effectiveness for the treatment of patients with primary immune thrombocytopenia. Its indication for other hemopathies or situations (like thrombocytopenia secondary to chemo- or radiotherapy, acute leukemia, myelodysplastic syndroms, acquired and hereditary bone marrow failure, and platelet donors) is under study. Eltrombopag may be particularly useful in patients with advanced chronic hepatitis or liver cirrhosis who require antiviral treatment. We present a minireview on the results of treatment with eltrombopag in patients chronically infected with hepatitis C virus, highlighting the benefits and mentioning possible adverse effects. In some studies eltrombopag increased the number of virological responses after clasical antiviral treatment of patients with chronic hepatitis C and reduced the transfusional requirements of those who had to be subjected to invasive surgery. Eltrombopag is a solution for many of these patients, which allows them receiving antiviral therapy and sometimes getting a sustained virological response, but they must be well monitored to prevent possible thromboembolic or bone marrow complications or liver failure occurrence. PMID:25253952

Mih?il?, Romeo-Gabriel; Cip?ian, Remus-C?lin

2014-01-01

448

Hepatitis A: Old and New  

PubMed Central

The hepatitis A virus (HAV), a picornavirus, is a common cause of hepatitis worldwide. Spread of infection is generally person to person or by oral intake after fecal contamination of skin or mucous membranes; less commonly, there is fecal contamination of food or water. Hepatitis A is endemic in developing countries, and most residents are exposed in childhood. In contrast, the adult population in developed countries demonstrates falling rates of exposure with improvements in hygiene and sanitation. The export of food that cannot be sterilized, from countries of high endemicity to areas with low rates of infection, is a potentially important source of infection. After ingestion and uptake from the gastrointestinal tract, the virus replicates in the liver and is excreted into the bile. Cellular immune responses to the virus lead to destruction of infected hepatocytes with consequent development of symptoms and signs of disease. Humoral immune responses are the basis for diagnostic serologic assays. Acute HAV infection is clinically indistinguishable from other causes of acute viral hepatitis. In young children the disease is often asymptomatic, whereas in older children and adults there may be a range of clinical manifestations from mild, anicteric infection to fulminant hepatic failure. Clinical variants include prolonged, relapsing, and cholestatic forms. Management of the acute illness is supportive, and complete recovery without sequelae is the usual outcome. Research efforts during World War II led to the development of passive immunoprophylaxis. Pooled immune serum globulin is efficacious in the prevention and attenuation of disease in exposed individuals. More recently, active immunoprophylaxis by vaccination has been accomplished. Future eradication of this disease can now be contemplated. PMID:11148002

Cuthbert, Jennifer A.

2001-01-01

449

A GIANT SAMPLE OF GIANT PULSES FROM THE CRAB PULSAR  

SciTech Connect

We observed the Crab pulsar with the 43 m telescope in Green Bank, WV over a timespan of 15 months. In total we obtained 100 hr of data at 1.2 GHz and seven hours at 330 MHz, resulting in a sample of about 95,000 giant pulses (GPs). This is the largest sample, to date, of GPs from the Crab pulsar taken with the same telescope and backend and analyzed as one data set. We calculated power-law fits to amplitude distributions for main pulse (MP) and interpulse (IP) GPs, resulting in indices in the range of 2.1-3.1 for MP GPs at 1.2 GHz and in the range of 2.5-3.0 and 2.4-3.1 for MP and IP GPs at 330 MHz. We also correlated the GPs at 1.2 GHz with GPs from the Robert C. Byrd Green Bank Telescope (GBT), which were obtained simultaneously at a higher frequency (8.9 GHz) over a span of 26 hr. In total, 7933 GPs from the 43 m telescope at 1.2 GHz and 39,900 GPs from the GBT were recorded during these contemporaneous observations. At 1.2 GHz, 236 (3%) MP GPs and 23 (5%) IP GPs were detected at 8.9 GHz, both with zero chance probability. Another 15 (4%) low-frequency IP GPs were detected within one spin period of high-frequency IP GPs, with a chance probability of 9%. This indicates that the emission processes at high and low radio frequencies are related, despite significant pulse profile shape differences. The 43 m GPs were also correlated with Fermi {gamma}-ray photons to see if increased pair production in the magnetosphere is the mechanism responsible for GP emission. A total of 92,022 GPs and 393 {gamma}-ray photons were used in this correlation analysis. No significant correlations were found between GPs and {gamma}-ray photons. This indicates that increased pair production in the magnetosphere is likely not the dominant cause of GPs. Possible methods of GP production may be increased coherence of synchrotron emission or changes in beaming direction.

Mickaliger, M. B.; McLaughlin, M. A.; Lorimer, D. R.; Palliyaguru, N. [Department of Physics, West Virginia University, Morgantown, WV 26506 (United States); Langston, G. I. [National Radio Astronomy Observatory, Green Bank, WV 24944 (United States); Bilous, A. V. [Department of Astronomy, University of Virginia, P.O. Box 400325, Charlottesville, VA 22904 (United States); Kondratiev, V. I. [Netherlands Institute for Radio Astronomy (ASTRON), Postbus 2, 7990 AA Dwingeloo (Netherlands); Lyutikov, M. [Department of Physics, Purdue University, 525 Northwestern Avenue, West Lafayette, IN 47907-2036 (United States); Ransom, S. M. [National Radio Astronomy Observatory, Charlottesville, VA 22903 (United States)

2012-11-20

450

Giant Congenital Melanocytic Nevi: A Case Report  

PubMed Central

Congenital melanocytic naevi which are formed by the overgrowth of melanocytes, are present at birth, which are called as bathing trunk, coat-sleeve or stocking naevi, which are commonly found over the back and the thigh areas . The giant congenital naevi of sizes which are greater than 20 cm are pigmented and are often hairy. The risk of malignant melanoma for the giant naevi is approximately 6% and 50% of the melanomas that develop by the age of two years, and 80% of those that develop by the age of seven years. So, an early removal is recommended The objective of this paper is to present a unique case of giant naevi along with a review of the literature. PMID:23450701

Das, Sudhanshu Ku.; M., Amarendra; Subudhi, Monalisa

2013-01-01

451

Giant Gravitons and a Correspondence Principle  

E-print Network

We propose a correspondence between the physics of certain small charge black holes in AdS_k x S^l and large charge black holes in AdS_l x S^k. The curvature singularities of these solutions arise, following Myers and Tafjord, from a condensate of giant gravitons. When the number of condensed giants N_g is much greater than the number of background branes N, we propose that the system has an equivalent description in terms of N giant gravitons condensed in a background created by N_g branes. Our primary evidence is an exact correspondence between gravitational entropy formulae of small and large charge solutions in different dimensions.

Balasubramanian, V; Balasubramanian, Vijay; Naqvi, Asad

2002-01-01

452

Giant plasmene nanosheets, nanoribbons, and origami.  

PubMed

We introduce Plasmene- in analogy to graphene-as free-standing, one-particle-thick, superlattice sheets of nanoparticles ("meta-atoms") from the "plasmonic periodic table", which has implications in many important research disciplines. Here, we report on a general bottom-up self-assembly approach to fabricate giant plasmene nanosheets (i.e., plasmene with nanoscale thickness but with macroscopic lateral dimensions) as thin as ?40 nm and as wide as ?3 mm, corresponding to an aspect ratio of ?75?000. In conjunction with top-down lithography, such robust giant nanosheets could be milled into one-dimensional nanoribbons and folded into three-dimensional origami. Both experimental and theoretical studies reveal that our giant plasmene nanosheets are analogues of graphene from the plasmonic nanoparticle family, simultaneously possessing unique structural features and plasmon propagation functionalities. PMID:25265019

Si, Kae Jye; Sikdar, Debabrata; Chen, Yi; Eftekhari, Fatima; Xu, Zaiquan; Tang, Yue; Xiong, Wei; Guo, Pengzhen; Zhang, Shuang; Lu, Yuerui; Bao, Qiaoliang; Zhu, Weiren; Premaratne, Malin; Cheng, Wenlong

2014-11-25

453

Contribution of hepatitis E virus in acute sporadic hepatitis in north western India  

PubMed Central

Background & objectives: Hepatitis E virus (HEV) causes acute viral hepatitis. Majority of the documented studies on hepatitis E have been focused on the incidence of this disease in northern and south central India. Limited data are available on HEV infection among acute sporadic hepatitis cases in north western India. The present study was undertaken to investigate the contribution of hepatitis E virus infection in sporadic hepatitis cases in Rajasthan and neighbouring States. Methods: Seven hundred and thirty six patients suspected to have viral hepatitis were screened for the hepatotropic viral markers, hepatitis A, B, C and E by using commercial enzyme immunoassay kits with a high sensitivity and specificity. The acute nature of HEV infection was also confirmed by the detection of HEV RNA by nested RT-PCR. Results: Hepatitis E was found to be the major cause of acute sporadic viral hepatitis (49.7%) in this region of India. Mixed infections of HEV-HAV (1.2%), HEV-HBV (6.1%), and HEV-HCV (1.7%) were also detected. No viral marker was detected in 32 per cent cases. Interpretation & conclusion: HEV was found as the major aetiological agent of acute sporadic viral hepatitis in Rajasthan (north western India). It is important to screen primarily for all the common enterically and parenterally transmitted hepatotropic viral markers in acute sporadic viral hepatitis. There is a need to do additional serological and molecular tests to identify the aetiological agent in the cases of acute hepatitis. PMID:23041743

Chandra, Nidhi Subhash; Sharma, Asha; Rai, Ramesh Roop; Malhotra, Bharti

2012-01-01

454

Hepatitis C and bile duct loss.  

PubMed Central

AIM: To assess whether bile duct loss is associated with the bile duct damage induced by chronic hepatitis C. METHODS: Sections were examined from 171 liver biopsy specimens from patients with chronic hepatitis C, 98 biopsy specimens from patients with chronic hepatitis B, 25 postmortem specimens from patients with no evidence of liver disease, and 23 patients who underwent protocol liver biopsy at the time of cholecystectomy. RESULTS: The bile duct:portal tract ratio for the hepatitis C group was 0.89, for the hepatitis B group was 0.93 and for the two control groups was 0.96 and 0.90, respectively. The ratio was lower in the hepatitis C group than in the other three. In no case of chronic hepatitis C was the ratio less than 0.60. In the hepatitis C group greater bile duct loss was seen in cirrhotic patients. CONCLUSIONS: Hepatitis C is associated with bile duct loss and this was related to the stage of the disease. However, in the cases studied this did not reach what is generally considered to be significant (that is, greater than 50% of portal tracts lacking bile ducts). This does not preclude a contributory effect of hepatitis C to bile duct loss in the presence of other risk factors, especially in liver transplant recipients. PMID:8943752

Goldin, R D; Patel, N K; Thomas, H C

1996-01-01

455

Hepatic focal nodular hyperplasia in children: Imaging features on multi-slice computed tomography  

PubMed Central

AIM: To retrospectively analyze the imaging features of hepatic focal nodular hyperplasia (FNH) in children on dynamic contrast-enhanced multi-slice computed tomography (MSCT) and computed tomography angiography (CTA) images. METHODS: From September 1999 to April 2012, a total of 218 cases of hepatic FNH were confirmed by either surgical resection or biopsy in the Sun Yat-sen Memorial Hospital of Sun Yat-sen University and the Cancer center of Sun Yat-sen University, including 12 cases (5.5%) of FNH in children (age ? 18 years old). All the 12 pediatric patients underwent MSCT. We retrospectively analyzed the imaging features of FNH lesions, including the number, location, size, margin, density of FNH demonstrated on pre-contrast and contrast-enhanced computed tomography (CT) scanning, central scar, fibrous septa, pseudocapsule, the morphology of the feeding arteries and the presence of draining vessels (portal vein or hepatic vein). RESULTS: All the 12 pediatric cases of FNH had solitary lesion. The maximum diameter of the lesions was 4.0-12.9 cm, with an average diameter of 5.5 ± 2.5 cm. The majority of the FNH lesions (10/12, 83.3%) had well-defined margins. Central scar (10/12, 83.3%) and fibrous septa (11/12, 91.7%) were commonly found in children with FNH. Central scar was either isodense (n = 7) or hypodense (n = 3) on pre-contrast CT images and showed progressive enhancement in 8 cases in the equilibrium phase. Fibrous septa were linear hypodense areas in the arterial phase and isodense in the portal and equilibrium phases. Pseudocapsule was very rare (1/12, 8.3%) in pediatric FNH. With the exception of central scars and fibrous septa within the lesions, all 12 cases of pediatric FNH were homogenously enhanced on the contrast-enhanced CT images, significantly hyperdense in the arterial phase (12/12, 100.0%), and isodense in the portal venous phase (7/12, 58.3%) and equilibrium phase (11/12, 91.7%). Central feeding arteries inside the tumors were observed on CTA images for all 12 cases of FNH, whereas no neovascularization of malignant tumors was noted. In 9 cases (75.0%), there was a spoke-wheel shaped centrifugal blood supply inside the tumors. The draining hepatic vein was detected in 8 cases of pediatric FNH. However, the draining vessels in the other 4 cases could not be detected. No associated hepatic adenoma or hemangioma was observed in the livers of the 12 pediatric cases. CONCLUSION: The characteristic imaging appearances of MSCT and CTA may reflect the pathological and hemodynamic features of pediatric FNH. Dynamic multi-phase MSCT and CTA imaging is an effective method for diagnosing FNH in children. PMID:23323007

Liu, Qing-Yu; Zhang, Wei-Dong; Lai, Dong-Ming; Ou-yang, Ying; Gao, Ming; Lin, Xiao-Feng

2012-01-01

456

Giant gigahertz optical activity in multiferroic ferroborate  

NASA Astrophysics Data System (ADS)

In contrast to the well-studied multiferroic manganites with a spiral structure, the electric polarization in multiferroic borates is induced within a collinear antiferromagnetic structure and can easily be switched by small static fields. Because of specific symmetry conditions, the static and dynamic properties in borates are directly connected, which leads to giant magnetoelectric and magnetodielectric effects. Here we prove experimentally that the giant magnetodielectric effect in samarium ferroborate, SmFe3(BO3)4, is of intrinsic origin and is caused by an unusually large electromagnon situated in the microwave range. This electromagnon reveals a strong optical activity exceeding 120 degrees of polarization rotation in a millimeter thick sample.

Kuzmenko, A. M.; Shuvaev, A.; Dziom, V.; Pimenov, Anna; Schiebl, M.; Mukhin, A. A.; Ivanov, V. Yu.; Bezmaternykh, L. N.; Pimenov, A.

2014-05-01

457

Giant-cell tumor of the patella.  

PubMed

We report a 38-year old man with a giant-cell tumor in a rare site, the patella. Primary patellar neoplasms are highly unusual. According to a survey by the Bone and Soft Tissue Tumor Committee of the Japanese Orthopaedic Association, of more than 2,126 giant-cell tumors of bone reported since 1972, only 22 were primary patellar neoplasms. We present a case of this rare entity along with its clinical and radiographic features. The first clinical symptom was anterior knee pain. Though anterior knee pain has numerous and varied causes, it is necessary to consider patellar bone tumors in the differential diagnosis. PMID:22358142

Yoshida, Yukihiro; Kojima, Toshio; Taniguchi, Masashi; Osaka, Shunzo; Tokuhashi, Yasuaki

2012-01-01

458

Tidal Dissipation in Stars and Giant Planets  

NASA Astrophysics Data System (ADS)

Astrophysical fluid bodies that orbit close to one another induce tidal distortions and flows that are subject to dissipative processes. The spin and orbital motions undergo a coupled evolution over astronomical timescales, which is relevant for many types of binary star, short-period extrasolar planetary systems, and the satellites of the giant planets in the Solar System. I review the principal mechanisms that have been discussed for tidal dissipation in stars and giant planets in both linear and nonlinear regimes. I also compare the expectations based on theoretical models with recent observational findings.

Ogilvie, Gordon I.

2014-08-01

459

Tidal dissipation in stars and giant planets  

E-print Network

Astrophysical fluid bodies that orbit close to one another induce tidal distortions and flows that are subject to dissipative processes. The spin and orbital motions undergo a coupled evolution over astronomical timescales, which is relevant for many types of binary star, short-period extrasolar planetary systems and the satellites of the giant planets in the solar system. I review the principal mechanisms that have been discussed for tidal dissipation in stars and giant planets in both linear and nonlinear regimes. I also compare the expectations based on theoretical models with recent observational findings.

Ogilvie, Gordon I

2014-01-01

460