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1

Giant cavernous hemangioma coexistent with diffuse hepatic hemangiomatosis presenting as portal vein thrombosis and hepatic lobar atrophy  

PubMed Central

A combination of giant hepatic hemangioma and diffuse hemangiomatosis is extremely rare in adults. Even when they are large, hemangiomas are soft and rarely compress adjacent structures. A 78-year-old man presented with abdominal pain and distension. Ultrasonography, computed tomography, and magnetic resonance imaging demonstrated a large expansile mass replacing the medial segment and caudate lobe with diffusely scattered nodules in the entire liver. The large hilar mass contained a central nonenhancing area and had a mass effect, leading to left portal vein occlusion. The image findings also revealed two unprecedented findings: left lateral segmental atrophy of the liver and recent portomesenteric vein thrombosis. The hepatic lesions were confirmed with hemangiomas by ultrasonography-guided biopsy. We diagnosed intrahepatic portal vein obstruction caused by a mass effect of giant hepatic hemangioma coexistent with diffuse hemangiomatosis, resulting in hepatic segmental atrophy and extrahepatic portal vein thrombosis. PMID:24936497

2014-01-01

2

Giant hepatic hemangioma and cross-fused ectopic kidney in a spaceflight participant.  

PubMed

Commercial spaceflight participants are typically older than traditional astronauts and often have medical conditions that make medical certification for flight difficult. This case report considers a 43-yr-old spaceflight participant who planned a short-duration Soyuz flight to the International Space Station (ISS). While he participated in many hazardous activities such as parachuting, hang gliding, scuba diving, Antarctic and jungle exploration, and deep sea submersible operations, he knew that several of his medical conditions precluded serving as a career astronaut. At the time of his initial spaceflight prescreen examination, he was known to have previous bilateral photorefractive keratectomy (PRK) for myopia and a cross-fused left ectopic kidney that would be disqualifying for a career astronaut. During the evaluation for the left single cross-fused ectopic kidney, a giant hepatic hemangioma was also discovered. In order to medically qualify for flight, the giant hepatic hemangioma was surgically removed. This case summary investigat*es the implications of a single cross-fused left ectopic kidney and the decision process and treatment implications for spaceflight medical certification in an individual with an asymptomatic giant hepatic hemangioma. PMID:20131656

Jennings, Richard T; Garriott, Owen K; Bogomolov, Valery V; Pochuev, Vladimir I; Morgun, Valery V; Garriott, Richard A

2010-02-01

3

[Interferon treatment of giant hemangioma].  

PubMed

As many as 10% to 20% of patients with disseminated hemangiomas involving vital organs fail to respond to conventional treatment with steroids, radiotherapy, laser or cyclophosphamide. For the last years, interferon-alpha-2 has been successfully used to treat complicated giant hemangiomas, because of its ability to inhibit endothelial cell proliferation. We report the case of a 3-months-old infant presenting with a giant cervicofacial hemangioma with extension to the chest wall and larynx, causing episodes of severe respiratory distress. CT scan and MRI revealed a second vascular lesion measuring 24 x 16 mm in the liver. Initial treatment with corticosteroids (prednisolone at a dose of 1-3 mg/kg/daily) and endoscopic laser barely improved the symptoms and the patient presented more episodes of shortness of breath requiring admission to the ICU. Interferon therapy was started at a dose of 3 million units/m2/every other day and was continued for 9 months. At the completion of the therapy, there was complete regression of the hemangioma. Four months later, the patient is asymptomatic. No side-effects were presented for hyperthermia when the treatment was started resolved with antithermics. Blood tests were always within the normal range. PMID:10570861

Castañón, M; Mayol, J; Muñoz, M E; Carrasco, R; Morales, L

1999-04-01

4

Right hepatectomy for giant cavernous hemangioma with diffuse hemangiomatosis around Glisson's capsule.  

PubMed

Diffuse liver hemangiomatosis with giant cavernous hemangioma in adult is extremely rare. A 35 year-old woman presented to hospital with main complaint of epigastric pain and abdominal fullness. An enhanced computed tomography scan revealed a massive liver tumor in right lobe about 150 mm in size. There was contrast enhancement at the periphery of the mass consistent with a cavernous hemangioma. She underwent right hepatectomy. Histologically, it was diagnosed as a cavernous hemangioma. And also, hemangiomatous lesions were scattered around the Glisson's capsule on the back ground liver. These hemangiomatous lesions were not recognized preoperatively. Even if we couldn't diagnose hemangiomatosis around the main giant hemangioma preoperatively, we need to take enough surgical margins because the giant hemangioma has the potential to have small hemangiomatous lesions around the tumor. We reported right hepatectomy for giant cavernous hemangioma with diffuse hepatic hemangiomatosis without an extrahepatic lesion in an adult. PMID:25009410

Ohkura, Yu; Hashimoto, Masaji; Lee, Seigi; Sasaki, Kazunari; Matsuda, Masamichi; Watanabe, Goro

2014-07-01

5

Right hepatectomy for giant cavernous hemangioma with diffuse hemangiomatosis around Glisson's capsule  

PubMed Central

Diffuse liver hemangiomatosis with giant cavernous hemangioma in adult is extremely rare. A 35 year-old woman presented to hospital with main complaint of epigastric pain and abdominal fullness. An enhanced computed tomography scan revealed a massive liver tumor in right lobe about 150 mm in size. There was contrast enhancement at the periphery of the mass consistent with a cavernous hemangioma. She underwent right hepatectomy. Histologically, it was diagnosed as a cavernous hemangioma. And also, hemangiomatous lesions were scattered around the Glisson’s capsule on the back ground liver. These hemangiomatous lesions were not recognized preoperatively. Even if we couldn’t diagnose hemangiomatosis around the main giant hemangioma preoperatively, we need to take enough surgical margins because the giant hemangioma has the potential to have small hemangiomatous lesions around the tumor. We reported right hepatectomy for giant cavernous hemangioma with diffuse hepatic hemangiomatosis without an extrahepatic lesion in an adult. PMID:25009410

Ohkura, Yu; Hashimoto, Masaji; Lee, Seigi; Sasaki, Kazunari; Matsuda, Masamichi; Watanabe, Goro

2014-01-01

6

[Surgical treatment of hepatic hemangioma].  

PubMed

Experience of treatment of 86 patients with hemangioma of the liver was summarized. New in the main tactics of treatment, envisaging the preoperative selective or superselective roentgen endovascular occlusion of the hepatic artery branches, ultrasonic surgical aspirator "SUS-101" ("Aloka" firm) application and the wound surface treatment with hot air stream (500 degrees C temperature), was offered. The mentioned method application permitted to prevent severe complications beginning, promoted the hepatic mass restoration even after vast resection of the organ in 3-4 months, functional indexes normalization and restoration of the patients' capacity to work. PMID:7658657

Vishnevski?, V A

1994-01-01

7

Recurrent giant hemangiomas of liver: Report of two rare cases with literature review.  

PubMed

Most hepatic hemangiomas (HHs) are small, asymptomatic and do not require clinical intervention. Surgical resection is only indicated for symptomatic hemangiomas. We report here cases of recurrent HHs in 2 women of 37 and 40 years old, who initially presented with abdominal pain and mass. Radiological examination of each tumor revealed a solitary tumor of 14 and 20 cm in diameter, respectively. Surgical liver segmental resections were performed in both, and the diagnosis of cavernous hemangioma was confirmed. Both patients had recurrent tumor on subsequent radiological examination 4-5 years after the initial surgery. In the first patient, a 15 cm recurrent hemangioma was resected, but multiple hemangiomas were again detected 8 years later occupying the other hepatic lobe, which was not amendable for resection. In the second patient, a 16 cm hemangioma was seen on radiogram, and because the lesion was not symptomatic, conservative observation was offered. Recurrence after liver resection of giant hemangioma is extremely rare. The pathogenesis of tumor progression and recurrence is unknown, as is the management of these patients with recurrent hemangioma, particularly when it is extensive and unresectable. PMID:23494295

Zhu, Hongfa; Obeidat, Khaled; Ouyang, Jie; Roayaie, Sasan; Schwartz, Myron E; Thung, Swan N

2012-11-27

8

Recurrent giant hemangiomas of liver: Report of two rare cases with literature review  

PubMed Central

Most hepatic hemangiomas (HHs) are small, asymptomatic and do not require clinical intervention. Surgical resection is only indicated for symptomatic hemangiomas. We report here cases of recurrent HHs in 2 women of 37 and 40 years old, who initially presented with abdominal pain and mass. Radiological examination of each tumor revealed a solitary tumor of 14 and 20 cm in diameter, respectively. Surgical liver segmental resections were performed in both, and the diagnosis of cavernous hemangioma was confirmed. Both patients had recurrent tumor on subsequent radiological examination 4-5 years after the initial surgery. In the first patient, a 15 cm recurrent hemangioma was resected, but multiple hemangiomas were again detected 8 years later occupying the other hepatic lobe, which was not amendable for resection. In the second patient, a 16 cm hemangioma was seen on radiogram, and because the lesion was not symptomatic, conservative observation was offered. Recurrence after liver resection of giant hemangioma is extremely rare. The pathogenesis of tumor progression and recurrence is unknown, as is the management of these patients with recurrent hemangioma, particularly when it is extensive and unresectable. PMID:23494295

Zhu, Hongfa; Obeidat, Khaled; Ouyang, Jie; Roayaie, Sasan; Schwartz, Myron E; Thung, Swan N

2012-01-01

9

Role of Perfusion CT Differentiating Hemangiomas from Malignant Hepatic Lesions  

PubMed Central

Objective: The purpose of the study was to determine the role of computed tomography (CT) perfusion in differentiating hemangiomas from malignant hepatic lesions. Materials and Methods: This study was approved by the institutional review board. All the patients provided informed consent. CT perfusion was performed with 64 multidetector CT (MDCT) scanner on 45 patients including 27 cases of metastasis, 9 cases of hepatocellular carcinoma (HCC), and 9 cases of hemangiomas. A 14 cm span of the liver was covered during the perfusion study. Data was analyzed to calculate blood flow (BF), blood volume (BV), permeability surface area product (PS), mean transit time (MTT), hepatic arterial fraction (HAF), and induced residue fraction time of onset (IRFTO). CT perfusion parameters at the periphery of lesions and background liver parenchyma were compared. Results: Significant changes were observed in the perfusion parameters at the periphery of different lesions. Of all the perfusion parameters BF, HAF, and IRFTO showed most significant changes. In our study we found: BF of more than 400 ml/100 g/min at the periphery of the hemangiomas showed sensitivity of 88.9%, specificity of 83.3%, positive predictive value (PPV) of 57.1%, and negative predictive value (NPV) of 96.7% in differentiating hemangiomas from hepatic malignancy; HAF of more than 60% at the periphery of hemangiomas showed sensitivity of 77.8%, specificity of 86.1%, PPV of 58.3% and NPV of 93.9% in differentiating hemangiomas from hepatic malignancy; IRFTO of more than 3 s at the periphery of hemangiomas showed sensitivity of 77.8%, specificity of 86.1%, PPV of 58.3%, and NPV of 93.9% in differentiating hemangiomas from hepatic malignancy. Conclusion: Perfusion CT is a helpful tool in differentiating hemangiomas from hepatic malignancy by its ability to determine changes in perfusion parameters of the lesions. PMID:24744967

Singh, Jagjeet; Sharma, Sanjiv; Aggarwal, Neeti; Sood, R G; Sood, Shikha; Sidhu, Ravinder

2014-01-01

10

Concurrent hepatic adenomatoid tumor and hepatic hemangioma: a case report  

PubMed Central

A 45-year-old male with alleged asymptomatic hepatic hemangioma of 4 years duration had right upper-quadrant pain and was referred to a tertiary hospital. Computed tomography and magnetic resonance imaging scans revealed a hypervascular mass of about 7 cm containing intratumoral multilobulated cysts. A preoperative liver biopsy was performed, but this failed to provide a definitive diagnosis. The patient underwent a partial hepatectomy of segments IV and VIII. The histologic findings revealed multifocal proliferation of flattened or cuboidal epithelioid cells and a highly vascular edematous stroma. Immunohistochemistry findings demonstrated that the epithelioid tumor cells were positive for cytokeratin (AE1/AE3), vimentin, calretinin, and cytokeratin 5/6, and were focally positive for CD10, and negative for WT1 and CD34, all of which support their mesothelial origin. Immunohistochemistry for a mesothelial marker should be performed for determining the presence of an adenomatoid tumor when benign epithelioid cells are seen. PMID:22893875

Kim, Ji-Beom; Shim, Ju-Hyun; Song, Gi-Won; Kim, Gwang Un; Jin, Young-Joo; Park, Ho-Seop

2012-01-01

11

Varied appearances of hepatic cavernous hemangiomas with sonography, computed tomography, magnetic resonance imaging and scintigraphy  

SciTech Connect

The incidental detection of an hepatic cavernous hemangioma may create a problem in differential diagnosis. The authors here review the characteristics of hemangiomas as recorded by various types of imaging.

Bree, R.L.; Schwab, R.E.; Glazer, G.M.; Fink-Bennett, D.

1987-11-01

12

Use of fluid-attenuated inversion recovery (FLAIR) pulse sequences for differential diagnosis of hepatic hemangiomas and hepatic cysts.  

PubMed

Fluid-attenuated inversion recovery (FLAIR) imaging of hepatic hemangiomas (10 patients, 16 lesions) and hepatic cysts (8 patients, 10 lesions) was performed. All hemangiomas were hypointense on T1-weighted images and hyperintense on T2-weighted images. With Gd-DTPA (0.1 mmol/kg), all hemangiomas were enhanced but not all cysts. It was necessary to perform contrast enhanced imaging to differentiate hepatic hemangiomas from hepatic cysts. However, on FLAIR imaging, hepatic hemangiomas were strongly hyperintense and 9 of the 10 hepatic cysts were isointense. One of the hepatic cysts was slightly hyperintense. FLAIR images were useful in differential diagnosis of hepatic hemangiomas and hepatic cysts without using Gd-DTPA. PMID:9359925

Ohkawa, M; Katoh, T; Nakano, S; Fujiwara, N; Mori, Y; Hino, I; Tanabe, M

1997-10-01

13

Scintigraphic diagnosis of hepatic hemangioma: its role in the management of hepatic mass lesions  

SciTech Connect

Hepatic cavernous hemangiomas are benign tumors of the liver that are often an incidental finding. They are usually asymptomatic but may cause symptoms when traumatized, may bleed spontaneously, or may produce pain by virtue of their large size and mass effect. A retrospective analysis of the clinical presentation, liver function tests, and diagnostic imaging procedures in 20 patients with hepatic hemangiomas is presented and the literature is reviewed. The 20 patients had 27 mass lesions as seen on liver scintigraphy, computed tomography, or sonography. Technetium-99m-labeled red blood cell flow studies and blood pool scintigrams showed delayed filling of the mass lesions, diagnostic of hemangiomas. This finding was not encountered in any other type of lesion. A new diagnostic algorithm is proposed in which flood-flow and blood-pool scintigraphy play a more prominent role in the diagnostic workup.

Moinuddin, M.; Allison, J.R.; Montgomery, J.H.; Rockett, J.F.; McMurray, J.M.

1985-08-01

14

Hemangiomas  

MedlinePLUS

... reduce the superficial component along with the steroid injection. Larger hemangiomas require oral steroids . A fairly large dose is needed but infants seem to handle this very well. Many children who are put on steroids will ...

15

Kupffer-phase findings of hepatic hemangiomas in contrast-enhanced ultrasound with sonazoid.  

PubMed

The aim of this study was to assess quantitatively the Kupffer-phase enhancement patterns of hepatic hemangiomas in contrast-enhanced ultrasound (CEUS) with Sonazoid. A total of 46 patients with 46 hepatic hemangiomas (17.1 ± 6.2 mm in diameter, 34 typical type and 12 high-flow type) underwent CEUS in the Kupffer phase. The lesion-to-liver contrast ratio in the Kupffer phase was quantitatively assessed for both types of hemangioma. Most of the hepatic hemangiomas, whether or not they were the high-flow type, were iso- to hypo-echoic relative to the surrounding liver parenchyma. The contrast ratio was -5.33 ± 6.70 dB for the high-flow hemangiomas and -4.54 ± 6.28 dB for the typical hemangiomas. There was no significant difference in contrast ratio between the two types of lesions (p = 0.73). All of the hemangiomas, whether of typical or high-flow type, are iso- to hypo-echoic relative to the surrounding liver parenchyma on Kupffer-phase imaging. PMID:24556559

Sugimoto, Katsutoshi; Moriyasu, Fuminori; Saito, Kazuhiro; Yoshiara, Hiroki; Imai, Yasuharu

2014-06-01

16

Giant mesenteric hemangioma of cavernous and venous mixed type: a rare case report  

PubMed Central

Background Although vascular tumours are one of the most common soft tissue neoplasms, those occurring in the gastrointestinal system are rare and cases involving mesentery are even further rare. Herein, we reported a rare case of giant hemangioma in mesentery of the small bowel. Case presentation A 5-year-old girl was admitted to the emergency room with abdominal pain and vomit for two days. Ultrasonography and computed tomography showed a giant solid-cystic abdominal mass, preferring diagnosis of teratoma. A large neoplasm in the mesentery of the small bowel was found in the surgical exploration, which was then resected with the partial bowel. A brown honeycomb mass in size 16 cm×8 cm×5 cm was observed to adhere to the small bowel, and diagnosed as hemangioma of cavernous and venous mixed type in final pathology. Conclusion The mesenteric hemangioma is extremely rare and the variable imaging tests are non-specific, thus the diagnosis is rarely made before surgery and usually established by histopathological investigation after surgery. So the mesenteric hemangioma is supposed to be differentiated in abdominal mass, either in adults or children. Complete surgical resection is the optimal treatment. PMID:24168418

2013-01-01

17

What is changing in indications and treatment of hepatic hemangiomas. A review.  

PubMed

Hepatic cavernous hemangioma accounts for 73% of all benign liver tumors with a frequency of 0.4-7.3% at autopsy and is the second most common tumor seen in the liver after metastases. Patients affected by hemangioma usually have their tumor diagnosed by ultrasound abdominal examination for a not well defined pain, but pain persist after treatment of the hemangioma. The causes of pain can be various gastrointestinal pathologies including cholelithiasis and peptic ulcer disease.The malignant trasformation is practically inexistent. Different imaging modalities are used to diagnosis liver hemangioma including ultrasonography, computed tomography (CT), magnetic resonance (MR) imaging, and less frequently scintigraphy, positronemission tomography combined with CT (PET/CT) and angiography. Imaging-guided biopsy of hemangioma is usually not resorted to except in extremely atypical cases. The right indications for surgery remain rupture, intratumoral bleeding, Kasabach-Merritt syndrome and organ or vessels compression (gastric outlet obstruction, Budd-Chiari syndrome, etc.) represents the valid indication for surgery and at the same time they are all complications of the tumor itself. The size of the tumor do not represent a valid indication for treatment. Liver hemangiomas, when indication exist, have to be treated firstly by surgery (hepatic resection or enucleation, open, laproscopic or robotic), but in the recent years other therapies like liver transplantation, radiofrequency ablation, radiotherapy, trans-arterial embolization, and chemotherapy have been applied. PMID:24927603

Toro, Adriana; Mahfouz, Ahmed-Emad; Ardiri, Annalisa; Malaguarnera, Michele; Malaguarnera, Giulia; Loria, Francesco; Bertino, Gaetano; Di Carlo, Isidoro

2014-01-01

18

Leberhaemangiome im Ultraschall und Computertomogramm. (Hepatic hemangiomas as diagnosed by ultrasonography and computed tomography).  

National Technical Information Service (NTIS)

A total of 62 cases where the clinical diagnosis of hepatic hemangioma had been established during the period between 1981 and 1983 on the basis of computed tomography and sonography were subjected to retrospective analysis with the aim of evaluating the ...

M. Sachse

1987-01-01

19

Hepatic cavernous hemangioma: diagnosis with /sup 99m/Tc-labeled red cells and single-photon emission CT  

SciTech Connect

During the performance of high-resolution real-time abdominal sonography, small echogenic hepatic masses are frequently discovered. A second imaging test to confirm the suspected diagnosis of hemangioma is often required. Planar labeled red-cell imaging will often not detect hemangiomas smaller than 3 cm. We studied 14 patients with labeled red-cell scintigraphy and single-photon emission CT (SPECT). Six hemangiomas were diagnosed by SPECT that would have been missed by planar imaging alone. All six were smaller than 2.5 cm. With the addition of SPECT, labeled red-cell scintigraphy has specificity and sensitivity that make it at least as reliable as dynamic CT for the noninvasive diagnosis of hepatic cavernous hemangioma.

Brodsky, R.I.; Friedman, A.C.; Maurer, A.H.; Radecki, P.D.; Caroline, D.F.

1987-01-01

20

Morphologic, Phenotypic and Functional Characteristics of Endothelial Cells Derived from Human Hepatic Cavernous Hemangioma  

Microsoft Academic Search

Backgrounds\\/Aims: The pathogenesis of cavernous hemangiomas is largely unknown, and it is speculated that abnormal vasculogenesis and angiogenesis may be involved. In this study, the characteristics of cavernous hemangioma endothelial cells (CHECs) derived from the human liver were analyzed in terms of morphology, phenotype and function and compared with human liver sinusoidal endothelial cells (LSECs). Methods and Results: By transmission

Wen-jian Zhang; Li-ya Ye; Lian-qiu Wu; Yu-ling Xin; Feng Gu; Ji-xiao Niu; Zhi-hua Yang; Guang-jin Zhu; Georges E. Grau; Jin-ning Lou

2006-01-01

21

Postinfantile Giant Cell Hepatitis: An Etiological and Prognostic Perspective  

PubMed Central

Giant cell hepatitis is common manifestation in pediatric liver diseases, but quite uncommon in adults, only about 100 cases reported in the English literature in the last two decades. Data for the present review were identified by a structured PubMed/MEDLINE search from 1963 to December 2012, using keywords postinfantile giant cell hepatitis (PIGCH), adult giant cell hepatitis, and syncytial giant cell hepatitis in adults and liver. We report a case of postinfantile giant cell hepatitis along with the review related to the etiology and respective outcome, as the literature in the last 20 years suggests. This condition is probably due to idiosyncratic or cytopathic response of individual to various hepatocytic stimuli. It is purely a histomorphological diagnosis and does not establish the etiology. Autoimmune liver diseases are most common etiology, in around 40% of cases, but various viruses, drugs, posttransplant condition, and other causes also have been reported. Prognosis depends upon the etiology. In this paper, we emphasized various causative factors of PIGCH and their respective outcome in patients affected by them. We also highlighted the possible pathogenesis and histopathological spectrum of this entity on the basis of description given in various studies and our limited experience of few cases. PMID:23555054

Bihari, Chhagan; Rastogi, Archana; Sarin, Shiv Kumar

2013-01-01

22

Intramuscular Hemangiomas  

PubMed Central

Context: Intramuscular hemangiomas are common in the general population and often present at medical and surgical clinics. Unfortunately, unfamiliarity with these lesions has led to a high percentage of misdiagnoses, inappropriate workup, and unnecessary referrals. Evidence Acquisition: A literature search was performed using Medline, Embase, PubMed, and Cochrane. The relevant articles and referenced sources were reviewed for additional articles that discussed the epidemiology, pathophysiology, investigation, and management of intramuscular hemangiomas. Clinical experience from experts in orthopaedics, musculoskeletal pathology, and musculoskeletal radiology was compared. The selected case studies are shared cases of the authors. Results and Conclusion: The pathophysiology of these lesions is not completely understood, but much can be implied from their underlying vascular nature. Isolated lesions are benign tumors that never metastasize but tend to enlarge and then involute over time. Magnetic resonance imaging is the imaging modality of choice. If a systemic disorder or malignancy is not suspected or has been ruled out, conservative management is the treatment of choice for most intramuscular hemangiomas. PMID:24427416

Wierzbicki, Joseph M.; Henderson, Jeffrey H.; Scarborough, Mark T.; Bush, Charles H.; Reith, John D.; Clugston, James R.

2013-01-01

23

Glomeruloid hemangioma.  

PubMed

A 64-year-old Japanese woman suffering from idiopathic thrombocytopenic purpura was treated with prednisolone. During the course of steroid withdrawal she developed parotid gland enlargement and cervical lymph node swelling with multiple dome-shaped red papules on her trunk and upper limbs. On admission the patient was found to have numbness of her lower limbs (polyneuropathy), lymph node swelling (organomegaly), high glucose level (endocrinopathy), Bence-Jones protein-kappa in the urine (M protein) and skin with hyperpigmentation, hypertrichosis and multiple glomeruloid hemangiomas (skin abnormalities), indicating polyneuropathy-organomegaly-endocrinopathy-M-protein-skin abnormality (POEMS) syndrome. The patient was also found to have peripheral edema, ascites, and pleural effusion. The glomeruloid hemangiomas had intravascular capillary growth, which was composed of conglomerates of capillaries resulting in structures resembling renal glomeruli. Cells within the capillary loops were lined by endothelial cells with scant cytoplasm (CD31(+)/CD34(+)/CD68(-)/CD105(+)/UEA-1(+)) while the outer surfaces of the loops were covered by either swollen endothelial cells containing PAS- and immunoglobulin-positive eosinophilic hyaline globules (CD31(+)/CD34(-)/CD68(-/+)/CD105(-)/UEA-1(-)) or cells without globules. These two phenotypically different endothelial cells were separated by alpha-smooth muscle actin-positive pericytes. Pericytes and endothelial cells covering the outer surface of the loops were bordered by basement membrane. Biopsy of parotid gland and lymph node indicated Sjögren's syndrome and Castleman's disease of a hyaline-vascular type, respectively. Resumed prednisolone therapy has been successful, and the patient was left with minimal residual symptoms. Glomeruloid hemangioma is a specific marker of POEMS syndrome and is related to Castleman's disease. Idiopathic thrombocytopenic purpura and Sjögren's syndrome may also be related. PMID:18477219

Yuri, Takashi; Yamazaki, Fumikazu; Takasu, Kosho; Shikata, Nobuaki; Tsubura, Airo

2008-06-01

24

Verrucous hemangioma.  

PubMed

A 13-year-old female presented complaining of swelling of the skin and purplish red papules and nodules on her left leg. These lesions had been present from early childhood and had slowly enlarged, increased in number, and become more verrucous. At the age of 8 years, one of the nodules had been excised by laser, but recurrence was noted within a few months. There was occasional pain and bleeding from the lesion. Physical examination revealed a group of several well-circumscribed, hyperkeratotic, blue-red, vascular plaques arranged linearly along the inside aspect of her left lower extremity, ranging in size from 0.5 to 4.0 cm in diameter (Fig. 1). Smaller, discrete satellite nodules with a similar appearance were noted in the vicinity. Histopathologic examination showed hyperproliferation and hyperkeratosis of the epidermis. The superficial dermis showed multiple, thin-walled, dilated blood-filled spaces (Fig. 2). Similar spaces were present in the lower dermis and subcutaneous tissue. A diagnosis of verrucous hemangioma was made. PMID:15485532

Wang, Gang; Li, Chunying; Gao, Tianwen

2004-10-01

25

Unusual Severe Complication Following Transarterial Chemoembolization for Metastatic Malignant Melanoma: Giant Intrahepatic Cyst and Fatal Hepatic Failure  

SciTech Connect

We describe a 45-year-old male patient with malignant melanoma who underwent hepatic arterial chemoembolization due to liver metastases. Four months after the procedure, the patient developed a giant cystic cavity in the liver. Cytologic examination of the cystic fluid retention revealed necrotic tumor material. The fluid was drained by percutaneous catheter, but the patient developed hepatic failure. This case represents another rare complication of transarterial chemoembolization and shows that transarterial chemoembolization may have rare fatal complications.

Ataergin, Selmin, E-mail: sataergin@superonline.co [GATA (Gulhane) Faculty of Medicine Gn. Dr. Tevfik Saglam caddesi, Department of Medical Oncology and Bone Marrow Transplantation Unit (Turkey); Tasar, Mustafa [GATA (Gulhane) Faculty of Medicine, Department of Radiology (Turkey); Solchaga, Luis [Case Western Reserve University, Department of Blood and Marrow Transplant, Ireland Cancer Center, University Hospitals Case Medical Center (United States); Ozet, Ahmet; Arpaci, Fikret [GATA (Gulhane) Faculty of Medicine Gn. Dr. Tevfik Saglam caddesi, Department of Medical Oncology and Bone Marrow Transplantation Unit (Turkey)

2009-03-15

26

Giant hepatic hydatid cyst with sub-fascial extension treated by open minimally invasive surgery: a case report  

PubMed Central

Introduction Hepatic hydatid disease can be successfully treated by a variety of modalities. Case Presentation We report a case of a 60 year old male with giant hepatic hydatid disease who presented with a huge cystic mass in the upper abdomen. Diagnosis was confirmed by serology, ultrasonography and CT scan. The patient was treated successfully by open minimally invasive surgery with minimum breaching of the peritoneal cavity using a laparoscopic trocar to evacuate the cyst. Conclusion The use of a laparoscopic trocar through a small abdominal incision in selected patients with hepatic hydatid disease with subfascial extension can be a safe, minimally-invasive option of treatment PMID:18226227

Duttaroy, Dipesh D; Kacheriwala, Samir; Duttaroy, Bithika; Jagtap, Jitendra; Patel, Gunjan; Modi, Nikhil

2008-01-01

27

Birthmarks and Hemangiomas  

MedlinePLUS

... pediatrician may need to conduct further tests. Port Wine Stains Port wine stains are flat malformations of small blood vessels, ... although they may occur anywhere. Unlike hemangiomas, port wine stains don’t go away, although they sometimes ...

28

Laser treatment of bladder hemangioma.  

PubMed

Bladder hemangiomas may occur singly or in association with systemic arteriovenous malformations. A total of 13 patients with bladder hemangiomas underwent treatment at this university. All patients had recurrent bleeding and neodymium:YAG laser energy was delivered endoscopically to the hemangioma. No treatment-related bleeding occurred in any patient, and all had a significant decrease in the frequency and intensity of bleeding episodes. Followup cystoscopic examinations have shown either complete eradication of the hemangioma or a marked decrease in size. Neodymium:YAG laser irradiation provides results superior to alternative therapy and is the preferred treatment for most patients with bladder hemangioma. PMID:2299718

Smith, J A

1990-02-01

29

Anti-CD20 Treatment of Giant Cell Hepatitis With Autoimmune Hemolytic Anemia.  

PubMed

Giant cell hepatitis with autoimmune hemolytic anemia (GCH-AHA) is a rare autoimmune disease of infancy characterized by severe liver disease associated with Coombs-positive hemolytic anemia. We recently showed that GCH-AHA is probably caused by a humoral immune mechanism. Such data support the use of rituximab, an anti-CD-20 monoclonal antibody specifically targeting B lymphocytes, as a treatment for GCH-AHA. We describe here the detailed clinical evolution of 4 children with GCH-AHA who showed a complete response to rituximab. All patients shared a severe course of the disease with poor control on standard and aggressive immunosuppression. Rituximab was well tolerated, and no side effects or infections were registered. Several doses were needed to induce remission, and 5 to 11 additional maintenance injections were necessary in the 2 more severe cases. Weaning from corticosteroids was achieved in all subjects. A steroid-sparing effect was noted in the 3 children who started rituximab early in the course of the disease. Overall, we show here that there is a strong rationale for treating GCH-AHA with rituximab. Early treatment could reduce the use of corticosteroids. Nevertheless, short-term steroids should be initially associated with rituximab to account for autoantibodies' half-life. Repeated injections are needed to treat and prevent relapses, but the best frequency and duration of treatment remain to be defined. PMID:25201797

Paganelli, Massimiliano; Patey, Natacha; Bass, Lee M; Alvarez, Fernando

2014-10-01

30

Neonatal diaphragmatic hemangioma  

Microsoft Academic Search

The first neonatal case of a hemangioma of the diaphragm in a neonate is reported. After 25 months the patient is well with no signs of recurrence. Diaphragmatic tumors should be considered in the differential diagnosis of neonatal thoracic masses. J Pediatr Surg 36:E21. Copyright © 2001 by W.B. Saunders Company.

S Cacciaguerra; G Vasta; A. G Di Benedetto; V Bagnara; S Guarnera; G Bartoloni; L Patanè

2001-01-01

31

Cardiac Hemangioma: A Case Report  

PubMed Central

Hemangioma of the heart, presenting as a primary cardiac tumor is extremely rare; it accounts for approximately 2% of all primary resected heart tumors. In our patient, the tumor was located in the orifice of the right lower pulmonary vein. Few cases of cardiac hemangiomas have been reported to arise from the left atrial (LA) wall. Left atrial hemangiomas, especially those attached to the LA wall, may be erroneously diagnosed as myxomas. Cardiac hemangioma is a rare disease; furthermore, a tumor arising from the LA wall and misconceived as a myxoma is extremely rare. We removed a mass misdiagnosed as a myxoma; it was pathologically confirmed to be a cardiac capillary hemangioma. Therefore, we report a rare case of a cardiac hemangioma misconceived as a myxoma; the tumor was removed successfully. PMID:24782967

Hong, Sung-Yong; Park, Kyung-Taek; Lee, Yang-Haeng; Cho, Kwang-Hyun; Seo, Jeong-Sook

2014-01-01

32

Cavernous Hemangioma of the Tongue  

PubMed Central

Hemangioma is a benign tumor of dilated blood vessels. It is most commonly seen in the head and neck region and rarely in the oral cavity. Hemangiomas in the oral cavity are always of clinical importance and require appropriate treatment. We report here a case of a 34-year-old female patient with a swelling on the lateral surface of tongue which did not respond to the sclerosing agent and was finally confirmed as cavernous hemangioma on histological evaluation. PMID:24073342

Kripal, Krishna; Rajan, Senthil; Ropak, Beena; Jayanti, Ipsita

2013-01-01

33

Targetoid hemosiderotic hemangioma - Case report*  

PubMed Central

Targetoid Hemosiderotic Hemangioma, also known as Hobnail Hemangioma, is a lesion of vascular origin, probably lymphatic. The most common clinical feature is a solitary violaceous papule surrounded by a pale, thin area and a peripheral ecchymotic ring, simulating a target. Histopathologically, there is a biphasic pattern, with dilated vessels in the superficial dermis and pseudoangiosarcomatous pattern in the deep dermis, and endothelial cells with hobnail morphology. A simple excision is curative. We report a rare case of Targetoid Hemosiderotic Hemangioma. PMID:25387500

Kakizaki, Priscila; Valente, Neusa Yuriko Sakai; Paiva, Daniele Loureiro Mangueira; Dantas, Fernando Luiz Teixeira; Goncalves, Sheila Viana Castelo Branco

2014-01-01

34

Treatment process for capillary hemangioma  

PubMed Central

Background Hemangiomas, usually, present at the first few months of life and are the most common benign tumor in children. There are various therapeutic methods for hemangioma. Capillary hemangioma is a type of hemangiomas. The steps of treatment of a child with capillary hemangioma in Taleghani Hospital of Gorgan, Iran, are reported. Case report In this report, it is described an 18-month-old child with capillary hemangioma on the right side of face. She was presented to the hematologic clinic of Taleghani Hospital of Gorgan. Three drugs, including prednisolon, propranolol and interferon alpha-2b (IFN-?-2b), were used for treating this patient. At the end of treatment, good results were obtained. After that, laser therapy was performed for fading the lesions. Conclusion Prescription of drug was our first choice for treating capillary hemangioma and it had a positive result without any complications. We used propranolol and IFN-?-2b for treating capillary hemangioma because of their better effect on this patient.

Mirbehbahani, NB; Rashidbaghan, A

2014-01-01

35

Hepatitis  

MedlinePLUS

... an important digestive liquid called bile . What Is Hepatitis? Hepatitis is an inflammation (say: in-fluh- may - ... the most common types of viral hepatitis. Continue Hepatitis A For kids, hep A is the most ...

36

Hepatitis  

MedlinePLUS

... Health Issues > Conditions > Abdominal > Hepatitis Health Issues Listen Hepatitis Article Body Hepatitis means “inflammation of the liver.” ... it has been associated with drinking contaminated water. Hepatitis Viruses Type Transmission Prognosis A Fecal-oral (stool ...

37

Infantile hemangiomas: A review  

PubMed Central

Infantile hemangiomas (IH) are the most common eyelid and orbital tumors of childhood. Although they are considered benign lesions that have a generally self-limited course, in the periocular region, they have the potential to cause amblyopia, strabismus, and severe disfigurement. The decision for treatment can be a source of anxiety for patients, parents, and physicians alike. There are numerous treatment modalities, including emerging therapies that may make treatment safer and more effective than ever before. This review discusses our current understanding of this disease, its management, and future therapies. PMID:23961007

Callahan, Alison B.; Yoon, Michael K.

2012-01-01

38

Imaging characteristics of two subtypes of congenital hemangiomas: rapidly involuting congenital hemangiomas and non-involuting congenital hemangiomas  

Microsoft Academic Search

Background: Common infantile hemangiomas (COMMON) occur in approximately 10% of infants by the age of 1 year, with a female predominance. Some hemangiomas can be fully developed at birth and are thus called congenital hemangiomas (CH). Within this population, two courses have been identified: rapidly involuting CH (RICH) and non-involuting CH (NICH). Little has been reported on the clinical prognosis and

Guillaume Gorincour; Victor Kokta; Francoise Rypens; Laurent Garel; Julie Powell; Josée Dubois

2005-01-01

39

Intramuscular hemangioma with phleboliths of the tongue  

PubMed Central

Intramuscular hemangioma (IMH) is relatively rare benign tumor of vascular origin. Phleboliths are calcified thrombi found in the presence of hemangioma. The main treatment of the hemangioma is a surgical extirpation based on location, accessibility, and cosmetic considerations. We herein report a rare case of IMH with phleboliths of the tongue with clinical, imaging, and histopathological findings.

Kamatani, Takaaki; Saito, Tomoyuki; Hamada, Yoshiki; Kondo, Seiji; Shirota, Tatsuo; Shintani, Satoru

2014-01-01

40

Symptomatic vertebral hemangiomas during pregnancy.  

PubMed

Symptomatic vertebral hemangiomas during pregnancy are rare, as only 27 cases have been reported in the literature since 1948. However, symptomatic vertebral hemangiomas can be responsible for spinal cord compression, in which case they constitute a medical emergency, which raises management difficulties in the context of pregnancy. Pregnancy is a known factor responsible for deterioration of these vascular tumors. In this paper, the authors report 2 clinical cases of symptomatic vertebral hemangiomas during pregnancy, including 1 case of spontaneous fracture that has never been previously reported in the literature. The authors then present a brief review of the literature to discuss emergency management of this condition. The first case was a 28-year-old woman at 35 weeks of gestation, who presented with paraparesis. Spinal cord MRI demonstrated a vertebral hemangioma invading the body and posterior arch of T-3 with posterior epidural extension. Laminectomy and vertebroplasty were performed after cesarean section, allowing neurological recovery. The second case involved a 35-year-old woman who presented with spontaneous fracture of T-7 at 36 weeks of gestation, revealing a vertebral hemangioma with no neurological deficit, but it was responsible for pain and local instability. Treatment consisted of postpartum posterior interbody fusion. With a clinical and radiological follow-up of 2 years, no complications and no modification of the hemangiomas were observed. A review of the literature reveals discordant management of these rare cases, which is why the treatment course must be decided by a multidisciplinary team as a function of fetal gestational age and maternal neurological features. PMID:24605997

Moles, Alexis; Hamel, Olivier; Perret, Christophe; Bord, Eric; Robert, Roger; Buffenoir, Kevin

2014-05-01

41

Single-Access Transumbilical Laparoscopic Unroofing of a Giant Hepatic Cyst Using Reusable Instruments  

PubMed Central

Introduction: Single-access laparoscopy has garnered growing interest in recent years in an attempt to improve cosmesis, reduce postoperative pain, and minimize abdominal wall trauma. Case Description: A female patient suffering from a symptomatic giant biliary cyst of the liver segments 4-7-8 was admitted for transumbilical single-access laparoscopic cyst unroofing. The procedure was performed using a standard 11-mm reusable trocar for a 10-mm, 30°- angled, rigid scope and curved reusable instruments inserted transumbilically without trocars. Operative time was 90 minutes, and the final incision length was 14 mm. The use of minimal pain medication permitted discharge on the third postoperative day, and after 25 months, the patient remains asymptomatic with a no visible umbilical scar. Conclusions: Giant biliary cysts can be removed by single-access laparoscopy. Because of this technique, surgeons work in ergonomic positions, and the cost of the procedure remains similar to that of the multitrocar technique. The incision length and the use of pain medication are kept minimal as well. PMID:23477183

Barabino, Matteo; Carnevali, Pietro; Surdeanu, Ion; Himpens, Jacques; Cadiere, Guy-Bernard; Donckier, Vincent

2012-01-01

42

Hepatitis  

Microsoft Academic Search

Blood-borne viral infections have implications for anaesthesia and intensive care because of their potential for transmission and as disease entities. An increasing number of hepatotropic viruses have been identified and may be acquired from faecal contamination (hepatitis A and E) or parenterally via body fluids (hepatitis B, C, D and G). These hepatotropic viruses preferentially cause hepatitis and exhibit this

Rick Keays

2004-01-01

43

Hemangioma of the temporalis muscle.  

PubMed

A rare case of an intramuscular hemangioma of the temporalis muscle is reported. The clinical examination, carotid arteriogram, computed tomographic scan, and aspiration cytology suggested the vascular nature of the tumor, but an exact diagnosis could only be made after histopathologic examination. Temporary occlusion of the ipsilateral external carotid artery and subperiosteal dissection permitted complete, wide excision without much bleeding. PMID:1985531

Sharma, B S; Chari, P S; Joshi, K; Rajvanshi, A

1991-01-01

44

Case report: consumptive hypothyroidism consequent to multiple infantile hepatic haemangiomas.  

PubMed

A 10-month-old infant with multiple infantile hepatic hemangiomas and developmental delay is reported. He was found to be profoundly hypothyroid. Evaluation and management issues are discussed. This case emphasizes the importance of screening for hypothyroidism in patients with hemangiomas and the potential therapeutic benefit of prednisolone therapy in this condition. PMID:18332720

Cho, Yoon Hi; Taplin, Craig; Mansour, Albert; Howman-Giles, Robert; Hardwick, Robert; Lord, David; Howard, Neville J

2008-04-01

45

Colonic varices due to intestinal cavernous hemangiomas  

Microsoft Academic Search

Summary Colonic varices are an unusual cause of rectal bleeding. Occurring most often in the setting of portal hypertension, colonic varices have also been linked to congenital vascular lesions. One such vascular lesion, the cavernous hemangioma, is rarely found in the bowel. We report a patient with cavernous hemangiomas involving skin, lower extremities, and gastrointestinal tract, who presented with chronic

David A. Lieberman; William W. Krippaehne; Clifford S. Melnyk

1983-01-01

46

Red Giant Red Giant White Giant  

E-print Network

Red Giant Red Giant White Giant Red Giant White Giant White Giant Blue Giant Blue Giant Blue GiantPower Points: 9 The hottest, brightest, and most massive stars. The three stars in Orion's belt, Alnitak, Alnilam and Mintaka, are blue giant stars. Mass: 10 - 70 SM StarPower Points: 10 The hottest, brightest

Bechtold, Jill

47

Anastomosing hemangioma of the kidney: a case report of a rare subtype of hemangioma mimicking angiosarcoma and review of the literature  

PubMed Central

Anastomosing hemangioma is a recently described, unusual variant of capillary hemangioma which seems to be unique for the genitourinary system, with a particular proclivity for the kidney. Histologically, it is characterized by a unique sinusoidal architecture reminiscent of splenic parenchyma that can lead to concern for angiosarcoma. We herein report a further case of anastomosing hemangioma originating in the right kidney of a 48-year-old Chinese man. The patient had a past medical history significant for hepatocellular carcinoma; this tumor was incidentally identified as an asymptomatic right renal mass during the periodical surveillance of the hepatic cancer. The resected tumor measured 2.5cm in maximum diameter and microscopically demonstrated an overall lobulated growth pattern with alternating cellular areas composed of anastomosing sinusoidal capillary-sized vessels lined by hobnail endothelial cells, and edematous, hyaline paucicellular areas. Cytologically the tumor cells were generally bland and exhibited positivity for CD31, CD34 immunohistochemically. The patient had been in a good status without evidence of tumor recurrence 12 months after the surgery. This rare variant renal hemangioma is in need of more recognition and should not be over-diagnosed as a malignance, particularly angiosarcoma. PMID:23573324

Zhao, Ming; Li, Changshui; Zheng, Jiangjiang; Sun, Ke

2013-01-01

48

Cavernous hemangiomas in patients with chronic liver disease: MR imaging findings.  

PubMed

The purpose of our study was to assess the difference in magnetic resonance imaging (MRI) features of cavernous hemangiomas in patients with chronic liver disease compared them with hemangiomas in normal livers. We retrospectively searched our records of MRI of the liver between October 1998 and June 2002, and identified 76 hemangiomas in 49 patients (18 men and 31 women; age range 29-81 years [mean, 57 years]). Hemangiomas were classified into 3 groups: patients with cirrhosis [group 1, 8 lesions in 8 patients], patients with chronic hepatitis [group 2, 6 lesions in 5 patients], and patients without underlying liver disease [group 3, 62 lesions in 36 patients]. Four radiologists, blinded to clinical information, retrospectively reviewed in consensus the MRI findings of hemangiomas for number, size, signal intensities on T1- and T2-weighted images, and enhancement patterns on early- and late-phase postcontrast images. The mean lesion numbers and sizes were 1.0 and 16.2 +/- 9.6 mm, 1.2 and 15.3 +/- 7.1 mm, and 1.7 and 26.1 +/- 24.7 mm in groups 1-3, respectively. There was a correlation (p < 0.05, coefficient: 0.35) between lesion number and severity of liver disease. Although there was no significant difference in lesion size among the 3 groups, all of 11 lesions larger than 4 cm in diameter belonged to group 3. Almost all lesions appeared moderately hypointense on T1-weighted images and moderately hyperintense on T2-weighted images. Twenty-seven lesions showed immediate homogeneous enhancement (pattern 1), and 49 showed peripheral nodular enhancement with centripetal enhancement progression (pattern 2). There was no difference in frequency of enhancement patterns among the 3 groups. Hemangiomas were more often solitary in livers with chronic liver disease, large lesions were exclusively seen in livers without chronic liver disease, and there was a trend for small lesions in patients with chronic liver disease. PMID:14972389

Mastropasqua, Maria; Kanematsu, Masayuki; Leonardou, Polytimi; Braga, Larissa; Woosley, John T; Semelka, Richard C

2004-01-01

49

Extra-Axial Cavernous Hemangioma  

PubMed Central

Two patients with extra-axial cavernous hemangioma who presented with headache and oculovisual disturbances were investigated with computed tomography and magnetic resonance imaging. The lesions masqueraded as basal meningioma, but this diagnosis was not supported by magnetic resonance spectroscopy in one patient. Cerebral angiography with embolization was indicated in one patient, but embolization was not justified in the other. Both patients underwent a pterional craniotomy. The lesions were extradural and highly vascular, necessitating excessive transfusion in one patient in whom gross total resection was achieved, and precluding satisfactory removal in the other. There was no mortality. Transient ophthalmoplegia, the only complication in one patient, was due to surgical manipulation of the cavernous sinus; it resolved progressively over 3 months. Extra-axial skull base cavernous hemangiomas are distinct entities with clinical and radiological characteristics that differ from those of intraparenchymal cavernous malformations. They can mimic meningiomas or pituitary tumors. In some cases, magnetic resonance spectroscopy may narrow the differential diagnoses. Surgical resection remains the treatment of choice, facilitated by preoperative embolization to reduce intraoperative bleeding and by the application of the principles of skull base surgery. Fractionated radiotherapy is an alternative in partial or difficult resections and in high-risk and elderly patients. ImagesFigure 1Figure 2Figure 3Figure 4 PMID:17167631

Kanaan, Imad; Jallu, Ashraf; Alwatban, Jehad; Patay, Zoltan; Hessler, Richard

2001-01-01

50

Hemangiomas, angiosarcomas, and vascular malformations represent the signaling abnormalities of pathogenic angiogenesis.  

PubMed

Angiogenesis is a major factor in the development of benign, inflammatory, and malignant processes of the skin. Endothelial cells are the effector cells of angiogenesis, and understanding their response to growth factors and inhibitors is critical to understanding the pathogenesis and treatment of skin disease. Hemangiomas, benign tumors of endothelial cells, represent the most common tumor of childhood. In our previous studies, we have found that tumor vasculature in human solid tumors expresses similarities in signaling to that of hemangiomas, making the knowledge of signaling in hemangiomas widely applicable. These similarities include expression of reactive oxygen, NFkB and akt in tumor vasculature. Furthermore, we have studied malignant vascular tumors, including hemangioendothelioma and angiosarcoma and have shown distinct signaling abnormalities in these tumors. The incidence of these tumors is expected to rise due to environmental insults, such as radiation and lumpectomy for breast cancer, dietary and industrial carcinogens (hepatic angiosarcoma), and chronic ultraviolet exposure and potential Agent Orange exposure. I hypothesize that hemangiomas, angiosarcomas, and vascular malformations represent the extremes of signaling abnormalities seen in pathogenic angiogenesis. PMID:19925405

Arbiser, J L; Bonner, M Y; Berrios, R L

2009-11-01

51

Extragingival pyogenic granuloma histologically mimicking capillary hemangioma  

PubMed Central

Pyogenic granuloma is a tumor-like proliferation to a non-specific infection. The tumor-like growth is considered to be non-neoplastic in nature and presents in various clinical and histological forms in the oral cavity. Hemangiomas are benign vascular anomalies characterized by benign proliferation of blood vessels. The aim of this article is to drive attention toward the uncommon location of capillary hemangioma on the palate. In spite of their benign nature, intraoral capillary hemangiomas are always clinically important to be diagnosed well in time and suitably managed. The lesion in the present case although clinically diagnosed as pyogenic granuloma gave a histological picture of capillary hemangioma when surgically excised.

Dahiya, Ritu; Kathuria, Abhinav

2014-01-01

52

Angiographic manifestations of intracerebral cavernous hemangioma  

Microsoft Academic Search

A case of intraventricular cavernous hemangioma is reported, with a review of the literature, especially that dealing with angiography of intracerebral lesions. Dense venous poolings and a localized area of venous stain were observed in this case.

Y. Numaguchi; M. Fukui; E. Miyake; T. Kishikawa; J. Ikeda; K. Matsuura; M. Tomonaga; K. Kitamura

1977-01-01

53

Epitheloid Hemangioma: A Report of Two Cases  

PubMed Central

We report two cases of epitheloid hemangioma presented with multiple nodular lesions over head and neck region. One of them gave history of bleeding on minor trauma. Pyogenic granuloma was considered as a differential diagnosis from the morphological appearance and history of bleeding. Nodular leprosy, sarcoidosis, and secondary syphilis were also considered. Histopathological examination of both was typical of epitheloid hemangioma, an entity commonly overlooked clinically due to its rarity.

Devi, Basanti; Jena, Swapna; Kar, Debjit; Patro, Sibasish; Behera, Binodini

2014-01-01

54

Multiple sclerosing hemangiomas of the lung.  

PubMed

Multifocal sclerosing hemangioma of the lung is a rare entity. While solitary pulmonary lesions by themselves are uncommon and few reports have been described, multifocal bilateral lesions are rare and limited instances have been cited in indexed medical literature. We herewith describe a case of multiple sclerosing hemangiomas of the lung, in a patient who also had a vascular malformation over the calf. PMID:15585708

Soumil, Vyas J; Navin, Bhambhani; Sangeeta, Desai; Na, Jambhekar; Sharma, Sanjay; Deshpande, Ramakant

2004-12-01

55

Mediastinal hemangioma: Masquerading as pleural effusion  

PubMed Central

We present a rare case of mediastinal hemangioma in a 4-year-old child. The child presented with cough and fever and the chest radiograph revealed right pleural effusion. On further work-up with chest computed tomography mediastinal cystic mass occupying the right hemithorax was identified. The cystic mass was resected completely through a right thoracotomy. Histopathological examination established the final diagnosis of mediastinal capillary hemangioma. PMID:24347874

Deepak, J.; Babu, M. Narendra; Gowrishankar, B. C.; Ramesh, S.

2013-01-01

56

Epitheloid hemangioma: a report of two cases.  

PubMed

We report two cases of epitheloid hemangioma presented with multiple nodular lesions over head and neck region. One of them gave history of bleeding on minor trauma. Pyogenic granuloma was considered as a differential diagnosis from the morphological appearance and history of bleeding. Nodular leprosy, sarcoidosis, and secondary syphilis were also considered. Histopathological examination of both was typical of epitheloid hemangioma, an entity commonly overlooked clinically due to its rarity. PMID:25284864

Devi, Basanti; Jena, Swapna; Kar, Debjit; Patro, Sibasish; Behera, Binodini

2014-09-01

57

Intramuscular cavernous hemangioma of the temporalis muscle.  

PubMed

Hemangiomas are frequent benign hereditary vascular tumors. Intramuscular hemangiomas, a distinctive type of hemangioma occurring within the skeletal muscle, account for less than 1% of all hemangiomas. They occur more often in the trunk and extremity muscles, whereas the involvement of the temporal muscle is extremely rare. A 34-year-old man with a mass in his left temporal fossa was admitted. Computed tomographic scan showed no erosion of the bone, and magnetic resonance imaging revealed an ovoid mass within the temporal muscle. The lesion was surgically excised, and histopathologic examination confirmed the diagnosis of cavernous hemangioma. The patient was not able to lift his left eyebrow right after the surgery. Two months after the surgery, the patient recovered from paralysis, and there was no recurrence of tumor 12 months after the surgery. We report the 27th cavernous hemangioma case of the temporalis muscle. Care must be taken to avoid possible stretch injury to facial nerve branches while resecting these tumors. PMID:24905945

Eryilmaz, Mehmet Akif; Varsak, Yasin Kür?ad; Gül, Zuhal; U?ur, Ay?enur

2014-07-01

58

Computed tomography and sonography of cavernous hemangioma of the liver  

SciTech Connect

Accuracy and limitations of computed tomography (CT) and sonography in the detection and diagnosis of cavernous hemangioma of the liver were analyzed in 39 cases. In 35 of 38 lesions examined by CT before and after bolus contrast enhancement, findings were dense contrast enhancement spreading in all directions on subsequent scans and/or density (other than capsule or septa) higher than normal hepatic parenchyma after 2 min. Lesions smaller than 1 cm were not detected. Misregistration in sequential scane prevented diagnosis of three of nine lesions smaller than 2 cm. Sonography revealed various patterns of mass, but in the smaller lesions, an extremely hyperechoic pattern was dominant. The contributions of CT and sonography depend on the size of the lesions.

Itai, Y.; Ohtomo, K.; Araki, T.; Furui, S.; Iio, M.; Atomi, Y.

1983-08-01

59

Hemangioma  

MedlinePLUS

Donate Donate One Time Monthly Event Tribute For brain tumor information and support Call: 800-886-ABTA (2282) or Email: ABTAcares@abta.org Donate Now Menu Brain Tumor Information Brain Anatomy Brain Tumor Symptoms Diagnosis Types ...

60

Pediatric Nasal Lobular Capillary Hemangioma  

PubMed Central

Background. LCH is a benign vascular growth of the skin and mucous membranes commonly affecting the head and neck. Since it was first described in the nineteenth century, this entity has been variously known as “human botryomycosis” and “pyogenic granuloma.” The shifting nomenclature reflects an evolving understanding of the underlying pathogenesis. We review the histopathology of and current epidemiological data pertaining to LCH which suggests that the development of these lesions may involve a hyperactive inflammatory response influenced by endocrine factors. We report two new cases of pediatric lobular capillary hemangioma (LCH) of the nasal cavity and review current theories regarding the etiology, diagnosis, and treatment of nasal LCH. Methods. Retrospective case series. Case Series. Two adolescent females presented with symptoms of recurrent epistaxis, nasal obstruction, and epiphora. Both patients underwent computed tomography imaging and biopsy of their intranasal mass. The tumors were excised using image-guided transnasal endoscopic technique. Seven other cases of nasal LCH have been reported to date in the pediatric population. Conclusion. Nasal LCH is a rare cause of an intranasal mass and is associated with unilateral epistaxis, nasal obstruction, and epiphora. We advocate for image-guided endoscopic excision of LCH in the adolescent population. PMID:22919398

Virbalas, Jordan M.; Bent, John P.; Parikh, Sanjay R.

2012-01-01

61

Retroperitoneal hemangioma demonstrated on blood pool scan.  

PubMed

Retroperitoneal hemangioma is a rare but clinically significant condition that can be challenging to diagnose and characterize on anatomical imaging alone. We present a case of an 80-year-old woman with diabetes and hypertension, who was found to have an abdominal mass diagnosed first on CT abdomen and pelvis in March 2011 and demonstrated to be stable on subsequent MRI study performed 16 months later in July 2012. The mass was later confirmed to be a hemangioma on a 99mTc-red cell study. PMID:24598345

Shah, Muhammad; Freeman, Leonard M; Chitkara, Munish; Chun, Kwang J

2014-04-01

62

Cavernous hemangioma involving the lacrimal outflow system.  

PubMed

A 22-year-old woman, 26 weeks pregnant, presented with a right nasolacrimal duct obstruction, nasal congestion with intermittent epistaxis, right globe displacement, and choroidal folds in the right eye. Noncontrast head CT revealed a mass involving the right nasolacrimal duct, nasal cavity, ethmoid sinuses, and orbit. Transnasal endoscopic resection was performed. Histopathology revealed a cavernous hemangioma involving the nasolacrimal duct and nasal cavity. Cavernous hemangiomas may occur rarely in the nasal cavity, paranasal sinuses, and/or the nasolacrimal duct. PMID:18030126

Kitzmann, Anna S; Moore, Eric J; Salomão, Diva R; Woog, John J

2007-01-01

63

Giant Pyogenic Granuloma in a Patient with Chronic Lymphocytic Leukemia  

PubMed Central

Pyogenic granuloma, also known as lobular capillary hemangioma, is a common benign vascular proliferative lesion that can present at any age on the skin or mucous membranes. Most lesions do not exceed 2 cm, but there are a handful of giant cutaneous pyogenic granulomas that have been reported, often in individuals with underlying immune dysfunction. Here, we report the first giant pyogenic granuloma in a patient with a hematological malignancy, chronic lymphocytic leukemia.

Plovanich, Molly; Tsibris, Hillary C.; Lian, Christine G.; Mostaghimi, Arash

2014-01-01

64

A Rapidly Enlarging Cutaneous Hemangioma in Pregnancy  

PubMed Central

This is a case of a rapidly enlarging cutaneous pedunculated tumor on a patient’s thumb during her pregnancy. This was excised and identified as a hemangioma. A literature search identified a possible hormonal factor in causing an accelerated growth of this tumor.

Ma'ayeh, Marwan; Purandare, Nikhil; Harrison, Michelle; Geary, Michael P.

2014-01-01

65

Gastrointestinal hemangioma in childhood: a rare cause of gastrointestinal bleeding.  

PubMed

Gastrointestinal (GI) hemangiomas are relatively rare benign vascular tumors. The choice of an appropriate diagnostic method depends on patient age, anatomic location, and presenting symptoms. However, GI hemangiomas are not a common suspected cause of GI bleeding in children because of their rarity. Based on medical history, laboratory results, and imaging study findings, the patient could be treated with either medication or surgery. Herein, we report 3 cases of GI hemangioma found in the small bowel, rectum, and GI tract (multiple hemangiomas). Better knowledge and understanding of GI hemangioma could help reduce the delayed diagnosis rate and prevent inappropriate management. Although rare, GI hemangiomas should be considered in the differential diagnosis of GI bleeding. PMID:25045368

Han, Eon Chul; Kim, Soo-Hong; Kim, Hyun-Young; Jung, Sung-Eun; Park, Kwi-Won

2014-05-01

66

Gastrointestinal hemangioma in childhood: a rare cause of gastrointestinal bleeding  

PubMed Central

Gastrointestinal (GI) hemangiomas are relatively rare benign vascular tumors. The choice of an appropriate diagnostic method depends on patient age, anatomic location, and presenting symptoms. However, GI hemangiomas are not a common suspected cause of GI bleeding in children because of their rarity. Based on medical history, laboratory results, and imaging study findings, the patient could be treated with either medication or surgery. Herein, we report 3 cases of GI hemangioma found in the small bowel, rectum, and GI tract (multiple hemangiomas). Better knowledge and understanding of GI hemangioma could help reduce the delayed diagnosis rate and prevent inappropriate management. Although rare, GI hemangiomas should be considered in the differential diagnosis of GI bleeding. PMID:25045368

Han, Eon Chul; Kim, Soo-Hong; Jung, Sung-Eun; Park, Kwi-Won

2014-01-01

67

Spinal Epidural Arteriovenous Hemangioma Mimicking Lumbar Disc Herniation  

PubMed Central

A spinal epidural hemangioma is rare. In this case, a 51 year-old female patient had low back pain and right thigh numbness. She was initially misdiagnosed as having a ruptured disc with possible sequestration of granulation tissue formation due to the limited number of spinal epidural hemangiomas and little-known radiological findings. Because there are no effective diagnostic tools to verify the hemangioma, more effort should be put into preoperative imaging tests to avoid misdiagnosis and poor decisions). PMID:23133733

Kim, Kyung Hyun; Song, Sang Woo; Lee, Soo Eon

2012-01-01

68

A Case of a Ruptured Sclerosing Liver Hemangioma  

PubMed Central

Hemangiomas are the most common benign tumors found in the liver, typically asymptomatic, solitary, and incidentally discovered. Although vascular in nature, they rarely bleed. We report a case of a 52-year-old woman with a previously stable hemangioma who presented to our hospital with signs and symptoms indicative of spontaneous rupture. We review the literature, focusing on diagnosis and management of liver hemangiomas. PMID:21994877

Papafragkakis, Haris; Moehlen, Martin; Garcia-Buitrago, Monica T.; Madrazo, Beatrice; Island, Eddie; Martin, Paul

2011-01-01

69

Capillary Hemangioma in Maxillary Anterior Region: A Case Report  

PubMed Central

ABSTRACT Hemangiomas are relatively common benign proliferative lesion of vascular tissue origin. They are often present at birth and may become more apparent throughout life. They are seen on facial skin, tongue, lips, buccal mucosa and palate as well as muscles. Hemangiomas occur more common in females than males. This case report presents a case of capillary hemangioma in maxillary anterior region in a 10-year-old boy. How to cite this article: Satish V, Bhat M, Maganur PC, Shah P, Biradar V. Capillary Hemangioma in Maxillary Anterior Region: A Case Report. Int J Clin Pediatr Dent 2014;7(2):144-147. PMID:25356016

Bhat, Manohar; Maganur, Prabhadevi C; Shah, Parth; Biradar, Vijay

2014-01-01

70

Intraosseous hemangioma arising in the clavicle.  

PubMed

Intraosseous hemangioma (IH) is commonly seen in the vertebral column and skull: however, IH occurring in the appendicular skeleton, including the clavicle, is uncommon. We herein report the case of a 69-year-old female presenting with IH of the left clavicle. The findings of preoperative imaging studies, including radiographs, computed tomography (CT), magnetic resonance imaging, fluorine-18-fludeoxyglucose ((18)F-FDG) positron emission tomography (PET)/CT and ultrasonography, are described. In particular, (18)F-FDG PET/CT showed an ill-defined osteolytic lesion with abnormally high FDG uptake. Surgical en bloc resection with preoperative embolization was carried out and a histopathological examination confirmed the presence of an intraosseous cavernous hemangioma in the clavicle. PMID:23990112

Matsumoto, Yoshihiro; Takahashi, Yusuke; Haraguchi, Akihisa; Okamoto, Tatsuro; Harimaya, Katsumi; Matsunobu, Tomoya; Endo, Makoto; Oda, Yoshinao; Iwamoto, Yukihide

2014-01-01

71

Cavernous hemangioma in the pineal region.  

PubMed

A cavernous hemangioma in the pineal region of a 22-year-old man is reported. Because the patient had diabetes insipidus and a contrast-medium-enhanced mass in his pineal region on computed tomography, a germinoma was suspected. A ventricular shunt was made and the tumor was irradiated, but without a response. After irradiation the tumor was entirely removed, and postoperatively the diabetes insipidus improved. PMID:6879419

Fukui, M; Matsuoka, S; Hasuo, K; Numaguchi, Y; Kitamura, K

1983-09-01

72

Arteriovenous hemangioma of the foot—A case report  

Microsoft Academic Search

We report a case of a 40-year-old woman who presented with a heel mass on her left foot. She underwent removal of the mass, which was found to be an arteriovenous hemangioma (AVH). Arteriovenous hemangioma is a rare tumours, especially in the foot which is extremely rare. This tumour should be considered in the differential diagnosis of a mass presenting

Venkat Perumal; Caycedo J. Francisco

2010-01-01

73

Intraventricular Cavernous Hemangiomas Located at the Foramen of Monro  

PubMed Central

Intraventricular cavernous hemangiomas are uncommon. Among them, those occurred at the foramen of Monro in the third ventricle may be of particular interest because of its rarity, development of hydrocephalus, being differentiated from other brain lesions. We present a rare case of intraventricular cavernous hemangioma at foramen of Monro which was resected through microsurgery and also review the relevant literatures. PMID:23091674

Choi, Chan-Young; Lee, Chae-Heuck

2012-01-01

74

Treatment of hemangiomas of infants with high doses of prednisone  

Microsoft Academic Search

OBJECTIVE: We reviewed our experience with the use of oral corticosteroid therapy in treating hemangiomas of infants to determine the optimal effective dose. STUDY DESIGN: During a 24-year period, 60 infants with hemangiomas were treated with an initial dose of either 3 or 5 mg\\/kg per day of orally administered prednisone for a period ranging from 6 to 12 weeks.

Naum Sadan; Baruch Wolach

1996-01-01

75

Co-development of pyogenic granuloma and capillary hemangioma on the alveolar ridge associated with a dental implant: a case report  

PubMed Central

Introduction The development of various benign oral mucosal lesions associated with dental implants, such as pyogenic granuloma or peripheral giant cell granuloma, has been rarely reported. However, the occurrence of vascular diseases, such as hemangioma, related to dental implants has not been explored in the literature. In this study, we report a case of co-development of pyogenic granuloma and capillary hemangioma on the alveolar ridge associated with a dental implant in a patient undergoing antithrombotic therapy. To the best of our knowledge, this is first case of hemangioma formation associated with a dental implant. Case presentation A 68-year-old Korean man was referred for intermittent bleeding and a dome-shaped overgrowing mass on his upper alveolar ridge. He underwent dental implantation 5 years ago, and was started on warfarin for cerebral infarction a year ago. He had experienced gum bleeding and gingival mass formation 6 months after warfarinization; then, his implant fixture was removed. However, his gingival mass has been gradually increasing. The gingival mass was surgically excised, and revealed the coexistence of pyogenic granuloma and capillary hemangioma in histological analysis of the specimen. The lesion has showed no recurrence for more than a year. Conclusions Regarding immunostaining features, the endothelial cell markers, CD34 and CD31, and the mesenchymal cell marker, vimentin, were strongly detected, but cell proliferation marker, Ki-67, was negatively expressed in the endothelial cells of the hemangioma portion. However, in the pyogenic granuloma portion, CD34 was almost negatively detected, whereas vimentin and Ki-67 were highly detected in the fibroblast-like tumor cells. According to these heterogeneous characteristics of the lesion, the patient was diagnosed with coexistence of pyogenic granuloma and capillary hemangioma associated with the dental implant on the attached gingiva. We recommend that patients with dental implants who have chronic peri-implantitis under antithrombotic therapy should be closely followed to ensure early detection of oral mucosal abnormalities. PMID:24934284

2014-01-01

76

Ulcerated infantile hemangioma treated with imiquimod.  

PubMed

A 5-month-old boy was observed in our department presenting with an ulcerated infantile hemangioma on the right buttock. This lesion appeared during the first week of life and had been growing progressively, showing ulceration for 3 weeks. We started treatment with corticosteroids, first with the association of betametasone and fusidic acid topically, and then systemically. After 6 weeks of oral treatment as there was no significant improvement, corticosteroid therapy was slowly tapered and local application of imiquimod 5 percent cream, on alternate days, was started. After 12 weeks of therapy with imiquimod there was complete resolution of the ulceration. There were no side effects. PMID:21971278

Mascarenhas, Rosa; Guiote, V; Agro, J; Henrique, M

2011-01-01

77

Sclerotherapy for the Treatment of Infantile Hemangiomas  

PubMed Central

Sclerotherapy is a simple, technically easy and effective mode of treatment for infantile hemangiomas (IH). It acts by blocking the growth of actively proliferating lesions, by targeting their vascularity accelerating their regression. Polidocanol is a commonly used sclerosant. We report two interesting cases of IH treated solely with polidocanol sclerotherapy and discuss the unique place this modality has in the armamentarium against IH. Sclerotherapy was found to be especially useful for large, exuberant and pedunculated lesions, producing rapid regression and preventing the disfiguring sequelae which are likely if large or pedunculated lesions are left to involute on their own. PMID:23112519

Grover, Chander; Khurana, Ananta; Bhattacharya, Sambit N

2012-01-01

78

Pathology Case Study: Hemangioma and Severe Thrombocytopenia  

NSDL National Science Digital Library

This is a transfusion pathology case study presented by the University of Pittsburgh Department of Pathology in which a 3-week-old female has hemangioma and severe thrombocytopenia. Visitors are given laboratory values and images, and are granted the opportunity to diagnose the patient. This is an excellent resource for students in the health sciences to familiarize themselves with using laboratory results to diagnose. It is also a helpful site for educators to use to introduce or test student learning in transfusion pathology medicine.

Bontempo, Franklin; Dorvault, Christine

2007-10-09

79

Epithelioid hemangioma of the orbit or angiolymphoid hyperplasia with eosinophilia.  

PubMed

A patient was referred to the department for an incidentally discovered right orbital mass on MRI. After surgical excision, histopathologic examination led to the diagnosis of epithelioid hemangioma, a tumor rarely located in the orbit, whose main histopathologic feature is an exuberant proliferation of small vascular channels lined by enlarged endothelial cells. The clinical characteristics and histopathology of epithelioid hemangioma allow differentiation with Kimura disease, angiosarcoma, intravascular papillary endothelial hyperplasia, and other vascular tumors that share the common feature of an abnormal proliferation of endothelial cells. Although epithelioid hemangioma is extremely rare, it should be considered in the differential diagnosis of orbital tumors. PMID:24026000

Sánchez-Orgaz, Margarita; Insausti-García, Alfredo; Gregorio, Laura Yébenes; Duralde, Alvaro Arbizu; Romero-Martín, Ricardo

2014-01-01

80

[Cavernous hemangioma of the spermatic cord: a case report].  

PubMed

Cavernous hemangioma of the spermatic cord is a very rare disorder. A 26-year-old man was admitted to our hospital with chief complaints of right intrascrotal mass and hematospermia on October 19, 1990. Physical examination revealed a hard, non-transilluminated mass in the right spermatic cord. The mass was resected via the groin. Pathological examination showed cavernous hemangioma. The patient's postoperative course was uneventful. This is only the fourth case of cavernous hemangioma of the spermatic cord to be reported in the literature in Japan. PMID:1609673

Harada, M; Tokuda, N; Tsubaki, H; Kase, T; Tajima, M; Sawamura, Y; Matsushima, M; Naoe, S

1992-05-01

81

Gastric cavernous hemangioma: A rare case with upper gastrointestinal bleeding  

PubMed Central

Upper gastrointestinal bleeding caused by a gastric hemangioma is a relatively rare occurrence. We report the case of a 65-year-old woman who suffered a sudden onset of hematemesis. Endoscopy revealed a 4×3 cm mass located in the gastric fundus. Abdominal contrast-enhanced CT revealed the shadow of enhancing linear blood vessels located in the gastric fundus. Based on her clinical appearance and the laboratory results, the patient was diagnosed with gastric hemangioma. In the laparotomy, a proximal gastrectomy was performed. The final diagnosis of cavernous hemangioma arising from the gastric fundus was confirmed by postoperative pathological examination. PMID:22848269

ZONG, LIANG; CHEN, PING; SHI, GUO HAO; WANG, LEI

2011-01-01

82

Beta blocker treatment of infantile conjunctival hemangiomas--observations from 2 cases.  

PubMed

Infantile conjunctival hemangiomas are rare lesions in comparison to cutaneous and orbital capillary hemangiomas. They generally present several weeks following birth as a red stromal mass. Recent reports of cutaneous and orbital infantile hemangiomas involuting in response to oral or topical beta blocker treatment suggest that infantile conjunctival hemangiomas could respond similarly. We report 2 cases of presumed infantile hemangiomas of the conjunctiva. One, associated with cutaneous hemangiomas, did not respond to oral propranolol; the other was isolated and resolved with topical timolol. PMID:24568991

Chang, Ta C; Estes, Robert

2014-02-01

83

Hemangioma of the Interatrial Septum: CT and MRI Features  

SciTech Connect

Hemangioma of the heart is a rare primary benign tumor mainly appearing as enhancing, homogenous, well-circumscribed mass. We report a case of a 61-year-old asymptomatic woman, whose echocardiography showed a cardiac mass, which was described as the atypical myxoma of the right atrium. For further imaging, contrast-enhanced computed tomography and cardiac magnetic resonance imaging were undertaken, which showed a tumor located in the interatrial septum with imaging characteristics of hemangioma. In the literature, cardiac hemangioma is usually described as an intensely enhancing mass. In our opinion, early peripheral puddling of contrast material with filling in on delayed images is a typical pattern of its enhancement. This characteristic, in addition to high signal intensity on T2-weighted images, allows differentiation of a hemangioma from other benign and malignant tumors.

Hrabak-Paar, Maja, E-mail: majahrabak@gmail.com [University Hospital Center Zagreb, University of Zagreb School of Medicine, Department of Diagnostic and Interventional Radiology (Croatia); Huebner, Marisa [University Hospital Mainz (Germany); Stern-Padovan, Ranka; Lusic, Mario [University Hospital Center Zagreb, University of Zagreb School of Medicine, Department of Diagnostic and Interventional Radiology (Croatia)

2011-02-15

84

Pedunculated cavernous hemangioma originating in the olfactory cleft.  

PubMed

Sinonasal cavernous hemangioma is a rare condition that usually affects the lateral wall of the nasal cavity. We report the case of a 77-year-old man who presented with severe epistaxis, nasal congestion, and olfactory dysfunction. Endoscopic examination of the nasal cavity revealed the presence of a red-blue tumor that had almost completely filled the nasopharynx. Preoperatively, it was difficult to distinguish this lesion from a juvenile nasopharyngeal angiofibroma. During endoscopic surgery, the tumor was found to originate in the left olfactory cleft, and it had a long peduncle that contained blood vessels. Postoperative histopathologic examination indicated that the mass was a cavernous hemangioma. To the best of our knowledge, this is the first case of an olfactory cleft cavernous hemangioma and the first case of olfactory cleft disease associated with a cavernous hemangioma to be reported in the English-language literature. PMID:25255356

Su, Kaiming; Zhang, Weitian; Shi, Haibo; Yin, Shankai

2014-09-01

85

Is systemic infliximab therapy effective for retinal cavernous hemangioma?  

PubMed

A 10-month-old infant with the diagnosis of retinal cavernous hemangioma involving the macula presented with an outward deviation of the right eye that has been noticed by her parents. Examination revealed a clearing vitreous hemorrhage, and grape-like clusters filled with blood in the posterior pole. After 4 cycles of intravenous infliximab over the period of 3 months, no evident change was noted on the size of the cavernous hemangioma.  PMID:25228188

Alsulaiman, Sulaiman M; Abouammoh, Marwan A; Al-Dahmash, Saad A; Abu El-Asrar, Ahmed M

2014-09-01

86

A rare cause of recurrent gastrointestinal bleeding: mesenteric hemangioma  

Microsoft Academic Search

Lower gastrointestinal hemorrhage accounts for approximately 20% of gastrointestinal hemorrhage. The most common causes of lower gastrointestinal hemorrhage in adults are diverticular disease, inflammatory bowel disease, benign anorectal diseases, intestinal neoplasias, coagulopathies and arterio-venous malformations. Hemangiomas of gastrointestinal tract are rare. Mesenteric hemangiomas are also extremely rare. We present a 25-year-old female who was admitted to the emergency room with

Mircelal Kazimi; Murat Ulas; Cem Ibis; Mutlu Unver; Nazan Ozsan; Funda Yilmaz; Galip Ersoz; Murat Zeytunlu; Murat Kilic; Ahmet Coker

2009-01-01

87

Surgical techniques for the removal of forehead hemangioma.  

PubMed

Hemangiomas of the bone are rare tumors, accounting for 0.5-1% of all benign skeletal tumors. Most of these tumors are found in the vertebral bodies and they are rarely seen in the cranial bones, where their frequency is 0.2% of all bone neoplasms. The authors, after reviewing the literature, describe their experience with a case of frontal bone hemangioma. PMID:16877918

Clauser, Luigi; Mandrioli, Stefano; Polito, Jessica; Galiè, Manlio

2006-07-01

88

Management of Infantile Hemangiomas: Current Trends  

PubMed Central

Infantile hemangiomas (IH) are common vascular tumours. IH have a characteristic natural course. They proliferate rapidly during the early infantile period followed by a period of gradual regression over several years. Most of the uncomplicated IH undergo spontaneous involution, with a small proportion of cases requiring intervention. These are children with IH in life-threatening locations, local complications like haemorrhage, ulceration and necrosis and functional or cosmetic disfigurements. Systemic corticosteroids have been the first line of treatment for many years. Recently, non-selective beta-blockers, such as oral propranalol and topical timolol, have emerged as promising and safer therapies. Other treatment options include interferon ? and vincristine which are reserved for life-threatening haemangiomas that are unresponsive to conventional therapy. This review mainly focuses on the current trends and evidence-based approach in the management of IH. PMID:25136206

Sethuraman, Gomathy; Yenamandra, Vamsi K; Gupta, Vishal

2014-01-01

89

Hobnail hemangioma: a pseudomalignant vascular lesion with a reappraisal of targetoid hemosiderotic hemangioma.  

PubMed

The clinicopathologic features of 15 cutanous hemangiomas having a distinctive and frequently pseudomalignant morphologic appearance are presented. There were 5 male and 9 female patients, whose ages at diagnosis ranged from 11 to 58 years (median 30.5). An angiomatous/pigmented, nontargetoid, flat, or exophytic lesion of variable duration was the main presenting sign. The tumor sizes ranged from 0.4 cm to 2 cm (median 1 cm). The locations included the lower limb, particularly the thigh (8); the trunk, including the shoulder area (4); the head (1); the gingiva (1); and the tongue (1). One patient had two lesions; none had a concomitant vascular anomaly or was suspected to have HIV infection. Treatment consisted of excisional biopsy in all cases. Follow-up information on 10 patients (range 4-66 months; median 13 months) showed no recurrence. On microscopic examination, the lesion showed a biphasic pattern characterized by the presence of well-formed, dilated, vascular channels in superficial dermis and a collagen-dissecting, pseudoangiosarcomatous pattern as the lesion infiltrated deeper into the dermis. The lining endothelium consistently showed distinctive hobnail cytomorphology; although there were endoluminal stromal papillae, there was no endothelial multilayering or tufting. Cytologic atypia was minimal or absent, and there were no mitoses. In 3 cases, the morphologic features were reminiscent of retiform hemangioendothelioma. Immunohistochemistry performed in 8 cases showed variable reactivity of endothelial cells with CD31, CD34, Factor VIII-related antigen, and Ulex europaeus agglutinin-1 in all cases; smooth muscle actin-positive pericytes were observed focally around some of the abnormal vascular spaces. The above-described hemangiomatous lesions share many features with so-called targetoid hemosiderotic hemangioma (a clinically descriptive term), but show a variable, often minimal, amount of hemosiderin deposition. The histologically descriptive term hobnail hemangioma is proposed to designate these lesions. Hobnail hemangioma should be distinguished from well-differentiated angiosarcoma, patch-stage Kaposi's sarcoma, and retiform hemangioendothelioma, with which it may be confused. PMID:9888709

Guillou, L; Calonje, E; Speight, P; Rosai, J; Fletcher, C D

1999-01-01

90

Intraosseous Cavernous Hemangioma: A Rare Presentation in Maxilla  

PubMed Central

Objective: Hemangiomas are benign vascular lesions mostly arising from soft tissues. However, intraosseous hemangioma is a rare entity, comprising only 1% of benign bone tumors. We describe here the presentation, diagnosis, and treatment of a 42-year-old woman with a painless hard swelling—diagnosed to be intraosseous hemangioma via orbital magnetic resonance imaging—localized on the left infraorbital margin. Methods: After en bloc excision of the mass with safety margins through a subciliary incision, the defect was reconstructed via Medpor, which was fixed to the drilled bones with polypropylene sutures. Results: Histopathological diagnosis of the specimen revealed intraosseous cavernous hemangioma. There seems to be no recurrence or any cosmetic deformity 3 months postoperatively. Conclusion: Total surgical excision is the preferred method of treatment for intraosseous hemangiomas with reconstruction. In this patient, we used Medpor for reconstruction of orbital floor, the infraorbital orbital rim and anterior wall of maxillary sinus. We think that Medpor is a good option since a natural smooth malar contour and adequate orbital rim can be achieved and there is no any other scar. PMID:25328568

Is?lgan, Servet Elcin; Cerkez, Cem; Otrakc?, Volkan; Serel, Savas

2014-01-01

91

A rare cavernous hemangioma of the adrenal gland?  

PubMed Central

INTRODUCTION Cavernous hemangiomas of the adrenal gland are rare. We report a case of a cavernous hemangioma of the adrenal gland presenting as an adrenal incidentaloma suspicious for adrenal cortical carcinoma (ACC). PRESENTATION OF CASE A 78 year old woman was admitted after a fall. Abdominal computed tomography revealed a large right adrenal lesion with features suspicious for adrenal cortical carcinoma (5.4 cm × 3.3 cm, unilateral, tumor calcifications, average Hounsfield units 55). The tumor was removed intact by a laparoscopic approach and pathology revealed a cavernous hemangioma of the adrenal gland. DISCUSSION Adrenal incidentalomas are found in up to 10% of patients undergoing abdominal imaging. Differential diagnosis includes both benign and malignant lesions. Guidelines for removal of adrenal incidentalomas recommend surgery based on functional status, size, and presence of concerning features on diagnostic imaging. Cavernous hemangiomas are rare, benign vascular malformations which can be challenging to distinguish pre-operatively from malignant lesions such as ACC. CONCLUSION Cavernous hemangiomas of the adrenal gland are exceedingly rare. These benign tumors have imaging features which may be suggestive of adrenal cortical carcinoma. The treatment of choice is surgical excision due the difficulty of excluding malignancy. PMID:24441435

Edwards, Janet P.; Stuart, Heather C.; Urbanski, Stefan J.; Pasieka, Janice L.

2013-01-01

92

Submandibular hemangioma with multiple phleboliths mimicking sialolithiasis: the first pediatric case.  

PubMed

Hemangiomas are the most common masses of the major salivary glands in parotid glands in childhood particularly. They occur more frequently in the parotid gland and rarely the submandibular gland. Changes in blood flow dynamics within hemangiomas may induce thrombus formation and phleboliths. Cavernous hemangioma may lead to thrombophlebitis in major salivary glands in adults. To our knowledge, cavernous hemangioma of submandibular glands containing phleboliths in childhood has not been described so far in the literature. In this article, we report the first pediatric case of a cavernous hemangioma containing multiple phleboliths in the submandibular gland mimicking submandibular sialolithiasis in a seven-year-old boy. PMID:25010807

Aynal?, Giray; Unal, Fatih; Yar?kta?, Murat; Yasan, Hasan; Ciri?, Metin; Y?lmaz, Omer

2014-01-01

93

Gamma Knife Radiosurgery for Choroidal Hemangioma  

SciTech Connect

Purpose: Patients with choroidal hemangioma (CH), a benign ocular hamartoma, frequently presents with visual disturbance as a result of exudative retinal detachment (RD), which originates in subretinal fluid accumulation. We report our experience using the Leksell Gamma Knife in the management of symptomatic CH. Methods and Materials: Seven patients with symptomatic CH (circumscribed form in 3 patients and diffuse form in 4) were treated with the Leksell Gamma Knife at our institution during a 7-year period. All patients presented with exudative RD involving the macula that resulted in severe visual deterioration. The prescription dose to the target margin was 10 Gy in all cases. The mean tumor volume receiving the prescription dose was 536 mm{sup 3} (range, 151-1,057). The clinical data were analyzed in a retrospective fashion after a mean follow-up of 34.4 months (range, 9-76). Results: The resolution of exudative RD was achieved within 6 months, and the visual acuity of the affected eye had improved at the latest follow-up examination (p = .018) in all patients. No recurrence of exudative RD occurred. Thinning of the CHs was observed in most patients; however, symptomatic radiation toxicity had not developed in any of the patients. Conclusion: Symptomatic CHs can be safely and effectively managed with Gamma Knife radiosurgery using a marginal dose of 10 Gy.

Kim, Yun Taek; Kang, Se Woong [Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of); Lee, Jung-Il, E-mail: jilee@skku.edu [Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of)

2011-12-01

94

Hypothesis: the metastatic niche theory can elucidate infantile hemangioma development.  

PubMed

Recent advances in the understanding of the metastatic phenomenon in cancer have led to the description of a metastatic niche. This concept describes a site prepared for the tumor cells in areas frequently associated with metastasis for the individual tumor studied. This niche is a "soil" that allows for the tumor cell or "seed" to lodge and grow. Certain aspects of the biology of infantile hemangioma cells suggest a relationship to the placenta as a possible site of origin for the hemangioma precursor cells. In this article, a relationship between the placenta, with or without a chorangioma and the hemangioma sites of localization, is hypothesized. The placenta is suggested as the site of humoral factors that prepare a niche similar to the function of malignant tumor cells. If the hypothesis proves to be valid, clues for possible treatment are outlined. PMID:20482680

Mihm, Martin C; Nelson, J Stuart

2010-04-01

95

[Endobronchial capillary hemangioma: a very rare cause of massive hemoptysis].  

PubMed

Tracheal capillary hemangioma is a very rare benign tumor of trachea which may present as massive hemoptysis. Minor to massive hemoptysis can be observed in these patients. Due to its small size and tracheal localization, diagnosis cannot be easily performed by using radiological investigations. Fifty-years-old male patient who was diagnosed as tracheal capillary hemangioma with bronchoscopic biopsy was presented in this case report. According to our knowledge, this is the eighth case report in the world literature. Tracheal capillary hemangioma must be kept in mind in patients with massive hemoptysis with normal radiologic features and bronchoscopic procedures (excision, argon, laser etc.) should be the first choice of therapy when diagnosed. PMID:22554374

Özy?lmaz, Ezgi; Yunsel, Dilek; Hanta, ?smail; Kuleci, Sedat; Kocaba?, Ali

2012-01-01

96

A Case of Calvarial Hemangioma in Cranioplasty Site  

PubMed Central

It is not uncommon for hemangiomas to occur in the calvarium, accounting for about 10% of the benign skull tumors. A 46-year-old man was presented with a palpable scalp mass on the left parietal region. Past medical history indicated that he had undergone cranioplasty 25 years prior due to a depressed skull fracture suffered from a traffic accident. Magnetic resonance imaging revealed mixed signal intensity mass on T1 -and T2-weighted images pushing a linear signal void lesion outward in the left parietal region. After total surgical removal along with cranioplasty, he was discharged without neurological deficits. Histological examination of the surgical specimen revealed a cavernous hemangioma. A skull hemangioma occurring at the site of a cranioplasty has not yet been reported. Therefore, authors report this case in combination with a pertinent literature review. PMID:20041060

Kang, Dong Wan

2009-01-01

97

An aggressive vertebral hemangioma in pregnancy: a case report  

PubMed Central

Introduction Pregnancy-related compressive myelopathy secondary to vertebral hemangioma is a rare occurrence and its treatment antepartum is rare. Case presentation A 19-year-old North African woman in her 38th week of pregnancy presented with paraplegia that progressed within 2 days after a rapidly progressive weakness of her lower limbs. Magnetic resonance imaging studies showed compression of her spinal cord in front of the fourth thoracic vertebra for suspected tuberculous spondylitis. A Caesarean section was done followed by corpectomy with a bone graft because we intraoperatively discovered a vertebral hemangioma. Pathology showed an aggressive hemangioma. Conclusion At any term of pregnancy, extensive neurological involvement which is rapidly progressive due to compression should be considered for immediate decompression. PMID:24943121

2014-01-01

98

Disfiguring facial hemangioma compromising labial functionality: a case report.  

PubMed

Hemangiomas are proliferative lesions characterized by increased endothelial cell turnover. Lip hemangiomas can distort lip anatomy and are at increased risk of ulceration and/or bleeding, which lead to impaired function and disfigurement. Surgery can provide active treatment but it can be problematic because vermilion tissue is unique and not found elsewhere on the body. Since there is no similar tissue that can easily be used for reconstructing missing vermilion, its preservation is essential for a satisfactory cosmetic result. We present the case of a 74 year old woman suffering from a large hemangioma of the mid-face and particulary with an angiomatous ulcerated lesion at the level of the lower lip. We describe clinical management and surgical treatment of this pathology. PMID:23648694

Rinaldi, Simona; Rossi, Antonio; Conversi, Andrea; Toscani, Marco; Tarallo, Mauro; Fino, Pasquale; Scuderi, Nicolò

2013-04-01

99

Isolated Cavernous Hemangioma: A Rare Benign Lesion of the Stomach  

PubMed Central

Gastric cavernous hemangioma is a relatively rare benign gastric disease. Here we report the case of a 25-year-old male patient who had been admitted complaining of epigastric pain and hematemesis. Preoperative imaging indicated that the mass lesion palpated in the epigastric region was a probable mesenchymal tumor of gastric origin. Due to the hypervascular nature and submucosal localization of the mass, we did not obtain definitive preoperative diagnosis by endoscopic biopsy. The histologic diagnosis of cavernous hemangioma was confirmed by post-resection histopathologial evaluation of the mass. PMID:23024741

Basbug, Murat; Yavuz, Ridvan; Dablan, Mahmut; Baysal, Birol; Gencoglu, Metehan; Yagmur, Yusuf

2012-01-01

100

Treatment of hemangiomas with 595 nm pulsed dye laser dermobeam.  

PubMed

The third generation dye lasers are pulsed dye lasers with a wavelength of 595 nm. Hemangiomas are the most common benign tumor in infancy, and ulceration is their most frequent complication. We used a 595 nm, Dermobeam 2000 laser (from Deka MELA Calenzano, Italy), using a dynamic skin cooling system (Spray) as the cooling method. The diameter of the spots was 7 mm, the energy density (fluence J/cm2) from 4 to 8 J/cm2. The emission modality (repetition rate) was repeated at 0.5 Hz. We initially chose a long pulse duration of 30 msec, but in the majority of cases it was 0.5 msec. The SmartSpray Cooling system parameters were : freezing, flood, duration, and advance. The spray length was from 60%. The delay (advance or anticipation) was 10 msec. The anesthetic effect limited the need for additional topical, local or general anesthetic. In a prospective study, we treated 16 patients with 22 cutaneous hemangiomas from July 2000 to February 2002 (over a 19 month period), with a mean follow up of 22.44 months (10 to 42 months). Our purpose was to review the therapeutic response of ulcerated hemangioma to the third generation pulsed dye laser. The female/male sex ratio was approximately 3 :1 (12 girls, and 4 boys). Patients were aged from 1 to 15 months, for a mean of 4.9 months. We tried to evaluate the therapeutic response of ulcerated hemangiomas to 595 nm wavelength pulsed dye laser. We observed no adverse effects; however 2 failures due to pain were recorded from ulcerated hemangiomas as the severity of the subcutaneous component of the mixed hemangiomas remained unchanged. These 2 cases showed proliferation of the subcutaneous component, and required general corticosteroids. We examined the children about 10 to 15 days after the first treatment, and evaluated the residual pain. The treatment could be continued while the pain level is low (1 session in most cases), and until the ulceration heals (after 4 sessions). Laser therapy was always effective on severe bleeding, but recurrences were frequent and it was necessary to treat hemangiomas until the end of the cicatrisation. Laser therapy is indicated for hemangiomas only in rare instances : due to the refractory ulceration failing to heal after 2 weeks of specialized dressing, aesthetic risk due to localization (such as philtrum, columella, or nasal margin). It is also possible to treat residual telangiectasia. No uniformly effective treatment modality was found. PMID:12695128

Michel, Jean-Loïc

2003-01-01

101

Stereotactic radiosurgery for cavernous sinus hemangiomas.  

PubMed

We performed this retrospective study to analyze the outcome of patients with cavernous sinus hemangioma (CSH) after stereotactic radiosurgery (SRS). We analyzed 19 patients with CSHs who were treated with SRS between 1998 and 2011. The median age of the patients was 50 years (range, 35-73 years), and 16 (84.2%) of the patients were female. SRS was performed as a primary treatment for 18 patients and to treat a residual lesion after surgical resection in one patient. Nine (47.4%) patients had cranial neuropathies in 14 cranial nerves before SRS, whereas five (26.3%) patients were initially asymptomatic. The mean volume of the CSHs was 6.1 ± 7.2 cm(3) (range, 0.3-32.3 cm(3)), and the median marginal dose at the 50% isodose line was 14.5 Gy (range, 11.5-16.0 Gy). The mean follow-up period was 37 months (range, 12-85 months). At the last follow-up, the lesion volume had decreased in all patients. The average tumor volume had decreased to 26% (range, 0-70%) of the initial volume at the last follow-up MRI. The first follow-up MRI, performed 6.1 ± 1.0 months after the SRS, showed that the tumor volume had decreased to 41% (range, 0-88%) of the initial volume. All 14 of the cranial neuropathies observed before SRS had improved, with complete remission in 12 (85.7%) cranial nerves and partial remission in two (14.3%). There were no radiation-induced neuropathies or complications during the follow-up period. SRS appears to be an effective and safe treatment modality for the management of CSHs. PMID:24584749

Song, Sang Woo; Kim, Dong Gyu; Chung, Hyun-Tai; Paek, Sun Ha; Han, Jung Ho; Kim, Yong Hwy; Kim, Jin Wook; Kim, Young-Hoon; Jung, Hee-Won

2014-05-01

102

Conservative treatment of infantile subglottic hemangioma with corticosteroids.  

PubMed

Infantile subglottic hemangioma is a rare, potentially fatal cause of airway obstruction. Diagnosis is made by history, neck roentgenograms, and direct laryngoscopy. A regimen of high-dose intravenous steroids in combination with oxygen and a mist tent is the preferred mode of therapy in cases where tracheostomy is not required. PMID:7059313

Kveton, J F; Pillsbury, H C

1982-02-01

103

Evaluation of intralesional propranolol for periocular capillary hemangioma  

PubMed Central

Background: The purpose of this study was to evaluate the use of intralesional propranolol injection in the management of periocular capillary hemangioma. Methods: A prospective study was performed in 22 consecutive patients with periocular hemangioma. Twelve patients underwent intralesional propranolol injection and ten patients underwent intralesional triamcinolone injection. The size of the lesion was measured serially every week during the first month, every 2 weeks for the second month, and then monthly for another 2 months. The refractive error and degree of ptosis if present were measured before injection and at the end of the study. Results: There was reduction in the size of hemangioma, astigmatic error, and degree of ptosis in both groups. The difference in outcome between both groups was not statistically significant. Rebound growth occurred in 25% of the propranolol group and 30% of the steroid group but responded to reinjection. No adverse effects were reported during or after intralesional propranolol injection. Conclusion: Intralesional propranolol injection is an alternative and effective method for treatment of infantile periocular hemangioma. PMID:21887095

Awadein, Ahmed; Fakhry, Mohamed A

2011-01-01

104

Propranolol in the treatment of upper airway hemangiomas.  

PubMed

Airway hemangiomas (AHs), which are common in infant airways, often cause significant upper airway obstruction. The various therapies used for AH have limitations and complications. Propranolol may have a potential role in its treatment, since it leads to regression or stabilization of cutaneous infantile hemangiomas. To date, only 4 previous case reports (7 patients) in which propranolol was used for AH have been published. Based on encouraging preliminary data on propranolol use for AH treatment, our goal was to further investigate propranolol as an effective initial treatment of upper AHs that cause significant obstruction symptoms. In this retrospective case series, we reviewed the medical records of 5 consecutive pediatric patients with AH (glottic and subglottic) treated with propranolol at a tertiary care children's hospital. All 5 patients were 2 months of age at the time of hemangioma diagnosis and had stridor and physical signs of severe upper airway obstruction. Hemangioma was diagnosed by flexible laryngoscopy or flexible bronchoscopy. All patients received propranolol 2 mg/kg/day and showed significant relief of obstruction symptoms within 24 hours of treatment initiation. All patients tolerated propranolol without significant cardiovascular complications. Outcomes from this case series, in conjunction with available case reports in the literature, suggest that propranolol is a safe initial treatment for symptomatic upper AH. PMID:23599104

Anderson de Moreno, Lauren C; Matt, Bruce H; Montgomery, Gregory; Kim, Young-Jee

2013-01-01

105

Conservative management of cavernous sinus cavernous hemangioma in pregnancy.  

PubMed

Cavernous sinus cavernous hemangiomas in pregnancy are extremely rare lesions. The precise management of these lesions remains unknown. The authors present a case of a cavernous hemangioma in pregnancy, centered within the cavernous sinus that underwent postpartum involution without surgical intervention. A 34-year-old pregnant patient (gravida 1, para 0) presented to an otolaryngologist with persistent headache and left-sided facial pain and numbness in the V1 distribution. While being treated for sinusitis, her symptoms progressed to include a left-sided oculomotor palsy and abducens palsy. Magnetic resonance imaging without contrast revealed an expansile mass within the left cavernous sinus consistent with a cavernous hemangioma. The patient was evaluated by a neurosurgeon who recommended close follow-up and postpartum imaging without surgical intervention. Although the lesion enlarged during pregnancy, the patient was able to undergo an uncomplicated cesarean section at 37 weeks. All facial and ocular symptoms resolved by 9 months postpartum, and MRI showed a decrease in lesion size and reduced mass effect. The authors conclude that nonsurgical management may be a viable approach in patients who have an onset or exacerbation of symptoms associated with cavernous sinus cavernous hemangiomas during pregnancy because postpartum involution may negate the need for surgical intervention. PMID:24724853

Haber, Jessica S; Kesavabhotla, Kartik; Ottenhausen, Malte; Bodhinayake, Imithri; Dinkin, Marc J; Segal, Alan Z; Lee, Young M; Boockvar, John A

2014-06-01

106

A rare neoplasm of the testis: capillary hemangioma.  

PubMed

Intratesticular vascular neoplasms are extremely rare tumors and mostly seen in children or young adults. We reported a case of capillary hemangioma of the testis to attract attention to testicular hemangioma and also to prevent invasive surgery of the testis. The patient was an 18-year-old boy with a testicular mass. Scrotal sonography revealed a varicocele in the left testis and a simple cyst in the left epididymis. There was a solid hypoechoic neoplastic area 75 mm in diameter in the right testis. The laboratory findings including tumor markers and serum levels of alpha-fetoprotein and beta-human chorionic gonadotrophin were normal. The patient underwent right orchiectomy and the pathology diagnosis was capillary hemangioma. Testicular neoplasms derived from connective tissue, blood vessels and musculature are uncommon and intratesticular tumors of vascular origin are extremely rare. There are only 21 cases reported in the literature. The pathologists and the surgeon have to be aware of this entity as the prognosis of the neoplasm determines the method of surgery. Capillary hemangioma of the testis can be similar to malignant testicular tumors on clinical presentation, as well as on ultrasonography and magnetic resonance imaging. Although it is impossible to differentiate a hemangioma from a seminoma before the operation, intraoperative frozen study may be helpful in the differential diagnosis. Frozen section must be performed if the neoplasm has significant vascular proliferation identified by Doppler sonography. Because of the benign nature of this lesion, conservative surgical treatment by means of tumor enucleation with preservation of the testis is possible if intraoperative frozen section examination can be performed. PMID:21469432

Mungan, Sevdegül; Turgutalp, Havvanur; Ersöz, Safak; Keskin, Ferda; Kutlu, Omer

2011-01-01

107

Giant Museum  

NSDL National Science Digital Library

In this activity children predict the size of a giant scale model of a rectangular object such as comb. They then make a model and check their predictions. Students should be familiar with measuring before beginning this activity.

2010-01-01

108

Comparison of fundamental sonography, tissue-harmonic sonography, fundamental compound sonography, and tissue-harmonic compound sonography for focal hepatic lesions  

Microsoft Academic Search

Image qualities of fundamental, tissue-harmonic, fundamental compound, and tissue-harmonic compound sonography for evaluating\\u000a focal hepatic lesions were compared. Two radiologists, blinded to the type of techniques and to the final diagnosis, independently\\u000a evaluated 384 images of 96 hepatic lesions: hemangiomas (n=35), hepatic cystic lesions (n=28), cirrhosis-related nodules (n=22), focal nodular hyperplasia (n=1), and metastases (n=10). All images were graded in

Se Hyung Kim; Jeong Min Lee; Kwang Gi Kim; Jong Hyo Kim; Joon Koo Han; Jae Young Lee; Byung Ihn Choi

2006-01-01

109

Giant Squid  

NSDL National Science Digital Library

How do you get two dead Giant Squid the size of a school bus from a fishing boat in Spain to a museum in Washington, DC, USA? Call in the Navy! Find out how Operation Calamari unfolded and how the museum managed to put their new Giant Squid on display. Also included is a Learn More section that provides background information on the scientists recorded in the podcast, lessons, images, and cool facts.

2009-01-01

110

Rapamycin suppresses self-renewal and vasculogenic potential of stem cells isolated from infantile hemangioma.  

PubMed

Infantile hemangioma (IH) is a common childhood vascular tumor. Although benign, some hemangiomas cause deformation and destruction of features or endanger life. The current treatments, corticosteroid or propranolol, are administered for several months and can have adverse effects on the infant. We designed a high-throughput screen to identify the Food and Drug Administration-approved drugs that could be used to treat this tumor. Rapamycin, an mTOR (mammalian target of Rapamycin) inhibitor, was identified, based on its ability to inhibit proliferation of a hemangioma-derived stem cell population, human vasculogenic cells, which we had previously discovered. In vitro and in vivo studies show that Rapamycin reduces the self-renewal capacity of the hemangioma stem cells, diminishes differentiation potential, and inhibits the vasculogenic activity of these cells in vivo. Longitudinal in vivo imaging of blood flow through vessels formed with hemangioma stem cells shows that Rapamycin also leads to regression of hemangioma blood vessels, consistent with its known anti-angiogenic activity. Finally, we demonstrate that Rapamycin-induced loss of stemness can work in concert with corticosteroid, the current standard therapy for problematic hemangioma, to block hemangioma formation in vivo. Our studies reveal that Rapamycin targets the self-renewal and vascular differentiation potential in patient-derived hemangioma stem cells, and suggests a novel therapeutic strategy to prevent formation of this disfiguring and endangering childhood tumor. PMID:21938011

Greenberger, Shoshana; Yuan, Siming; Walsh, Logan A; Boscolo, Elisa; Kang, Kyu-Tae; Matthews, Benjamin; Mulliken, John B; Bischoff, Joyce

2011-12-01

111

A Case of Capillary Hemangioma of Lingular Segmental Bronchus in Adult  

PubMed Central

Capillary hemangioma of the tracheobronchial tree is an extremely rare benign tumor in adults, especially those located in the bronchus. Characteristics and treatment of capillary hemangiomas of adult tracheobronchial trees have not been well known. We present a 61-year-old man with hemoptysis, which was caused by a small tiny nodule in the left lingular segmental bronchus. The nodule was removed by a forcep biopsy, via flexible bronchoscopy, and it was revealed to be capillary hemangioma. A small isolated endobronchial capillary hemangioma can be treated with excisional forcep biopsy, but a risk of massive bleeding should not be overlooked. PMID:23946758

Cho, Nam Jun; Baek, Ae Rin; Kim, Junghyun; Park, Jong-Sook; Jang, An-Soo; Park, Jai Soung; Koh, Eun Suk

2013-01-01

112

Endoscopic nonembolized resection of an extensive sinonasal cavernous hemangioma: A case report and literature review  

PubMed Central

Sinonasal hemangiomas, although rare, must be considered in the evaluation of intranasal masses with profuse epistaxis. Although the availability of literature discussing cavernous hemangiomas in this location is limited, there have been no case reports of exclusively soft tissue sinonasal cavernous hemangiomas extending to the anterior skull base (ASB) that were resected purely endoscopically. Here, we describe the successful endoscopic resection of an extensive right sinonasal cavernous hemangioma extending to but not invading the ASB. Although highly vascular, in select cases, these tumors can be successfully resected endoscopically without embolization by experienced endoscopic sinus and skull base surgeons. PMID:24498525

Kovalerchik, Olga; Husain, Qasim; Mirani, Neena M.; Liu, James K.

2013-01-01

113

Application of 128 slice 4D CT whole liver perfusion imaging in hepatic tumor.  

PubMed

To investigate the clinical significance of 128 slice whole liver four dimensional computed tomography (4D CT) in diagnosis and differential diagnosis of hepatic disease, by characterizing and comparing perfusion maps in two common hepatic tumors: hepatocellular carcinoma (HCC) and liver hemangioma. 45 patients with HCC and 40 patients with liver hemangioma were subjected to 128 slice 4D CT of the whole liver perfusion scan, perfusion images were obtained, and data were processed by the perfusion software. Four perfusion parameters generated automatically were used to characterize and compare the perfusion of tumor tissue and surrounding hepatic parenchyma: blood flow perfusion (BF), arterial liver perfusion (ALP), portal venous perfusion (PVP), and hepatic perfusion index (HPI). Volumetric CT perfusion data then reconstructed to yield 4D CT angiography. Morphological observation was made regarding to the blood supply of tumor, intrahepatic vasculature. (1) In both HCC and hepatic hemangioma, BF, ALP, HPI were higher (P < 0.01), whereas PVP were lower (P < 0.01) in tumor tissue than the surrounding hepatic parenchyma (within 1 cm of lesion). Compared with liver hemangioma tumor tissue, BF, ALP, PVP were lower in HCC tumor tissue (P < 0.05; 0.01; 0.01), but HPI is higher (P < 0.05). For the perfusion of the surrounding parenchyma, BF and ALP were higher (P < 0.001), PVP was lower (P < 0.001) in HCC, while HPI was unchanged. (2) Among 45 cases with HCC, cancer feeding artery was found in 28 cases. In 20 cases feeding artery was shown as thickening, rigid, or distorted. Tumor thrombus in portal vein was found in 14 cases. For total of 40 cases with liver hemangioma, in 23 cases blood vessels are shifted due to compression from tumor mass, the rest 17 cases show normal vasculature. With application of 128 slice 4D CT, whole liver perfusion scan can reliably reflect the hemodynamic characteristics of HCC and hepatic hemangioma, proving to be a valuable adjunct to conventional imaging techniques of liver for early detection, differential diagnosis, and determining surgical resection range as well as estimating prognosis for hepatic tumors. PMID:24691926

Guo, Meiling; Yu, Yongmei

2014-09-01

114

Cavernous hemangioma of the tongue: A rare case report  

PubMed Central

Hemangiomas are developmental vascular abnormalities and more than 50% of these lesions occur in the head and neck region, with the lips, tongue, buccal mucosa, and palate most commonly involved. They are considered as hamartomas rather than true neoplasms. Here we report a case of hemangioma of the body of the tongue, discussing the diagnostic aspects and treatment modalities of such lesion and emphasizing the role of the color Doppler ultrasonography, especially in the diagnosis and treatment. Factors such as patient's age, size and site of lesion and the proximity of lesion to vital structure are paramount in the determination of the therapeutic approach and surgical excision. Even though radiotherapy, cryotherapy, laser therapy, medical treatment, injection of sclerosing substances and the selective embolization of the lingual artery seem to have some efficacy, the author conclude that surgery is the therapy of choice in the isolated vascular lesions of the body of the tongue. PMID:24808705

Kamala, K. A.; Ashok, L.; Sujatha, G. P.

2014-01-01

115

Painful erections secondary to rare epithelioid hemangioma of the penis  

PubMed Central

Epithelioid hemangioma is a rare benign vascular tumour that atypically involves the penis and usually presents as a painful nodule. A 35-year-old man presented with a 5-month history of painful erections without a clinically apparent lesion or deformity. Magnetic resonance imaging (MRI) with pharmacologically induced erection demonstrated a 1.3-cm nodular lesion deep to the skin at the base of his penis. Following local excision of the lesion, which was diagnosed as an epithelioid hemangioma, the patient was symptom free. This case demonstrates a rare etiology of painful erections with a unique presentation. To the authors’ knowledge, it is also the first report of MRI with intracavernosal injection of trimix to assess for a specific cause of painful erections. PMID:25295139

Barber, Evan; Domes, Trustin

2014-01-01

116

Cavernous hemangioma of the tongue: A rare case report.  

PubMed

Hemangiomas are developmental vascular abnormalities and more than 50% of these lesions occur in the head and neck region, with the lips, tongue, buccal mucosa, and palate most commonly involved. They are considered as hamartomas rather than true neoplasms. Here we report a case of hemangioma of the body of the tongue, discussing the diagnostic aspects and treatment modalities of such lesion and emphasizing the role of the color Doppler ultrasonography, especially in the diagnosis and treatment. Factors such as patient's age, size and site of lesion and the proximity of lesion to vital structure are paramount in the determination of the therapeutic approach and surgical excision. Even though radiotherapy, cryotherapy, laser therapy, medical treatment, injection of sclerosing substances and the selective embolization of the lingual artery seem to have some efficacy, the author conclude that surgery is the therapy of choice in the isolated vascular lesions of the body of the tongue. PMID:24808705

Kamala, K A; Ashok, L; Sujatha, G P

2014-01-01

117

Breast hemangioma with difficulty in preoperative diagnosis: a case report.  

PubMed

We report a rare case of breast hemangioma found in a 70-year-old Japanese female. Before seeking medical attention, the patient noticed a hard mass in her right breast but denied associated symptoms. A mammography revealed a well-circumscribed, highly dense, lobular nodule located in the middle inter portion of the right breast. To verify this finding, we used ultrasonography which revealed an irregular, iso-echoic nodule measuring 10 mm in the same portion. Based on these findings, we suspected a malignancy and performed a core needle biopsy. Unexpectedly, a histological examination of the biopsy displayed normal vasculature, adipose, and mammary tissues. In order to make an accurate diagnosis, the mass was surgically excised under general anesthesia and sent to pathology. Pathological findings of the mass were positive for breast hemangioma, and the patient has had no recurrence of the disease for the past 24 months. PMID:25312096

Funamizu, Naotake; Tabei, Isao; Sekine, Chikako; Fuke, Azusa; Yabe, Mitsuo; Takeyama, Hiroshi; Okamoto, Tomoyoshi

2014-01-01

118

Percutaneous Technique for Sclerotherapy of Vertebral Hemangioma Compressing Spinal Cord  

SciTech Connect

Purpose: In this study we report a percutaneous technique to achieve sclerosis of vertebral hemangioma and decompression of the spinal cord and nerve roots. Methods: Under CT guidance the affected vertebral body is punctured by a biopsy needle and sclerosant is injected directly into the tumor. In the case of large paravertebral extension, additional injection is given in the paravertebral soft tissue component to induce shrinkage of the whole tumor mass and release of the compressed spinal cord. Results: Using this technique we treated five patients in whom vertebral hemangioma gave rise to neurologic symptoms.In three patients, sclerotherapy was the only treatment given. In the other two patients, sclerotherapy was preceded by transcatheter embolization. Neither decompressive surgery, radiation therapy nor stabilization was required with this technique. Conclusion: Our experience with CT-guided intraosseous sclerotherapy has proved highly satisfactory.

Gabal, Abdelwahab M. [Al-Azhar University Medical Center, Sayed GalalHospital, Port Saeed Str. 540, Cairo 11563 (Egypt)

2002-12-15

119

Cavernous hemangioma of the frontal bone: a case report  

PubMed Central

Introduction Cavernous hemangiomas are rare benign bone tumors and those at the level of the cranial bones are even rarer. Case presentation A 50-year-old woman of Italian ethnicity presented with a frontal mass. A computed tomography scan showed an osteolytic lesion and a magnetic resonance imaging scan revealed a hypointense lesion on the T1-weighted image and a hyperintense lesion on the T2-weighted image. We performed a tailored craniectomy and cranioplasty. Histological examination revealed a cavernous hemangioma. Conclusions These benign tumors do not have classic radiographic features and so can be misinterpreted as lesions like multiple myeloma or osteosarcoma. Consequently, the diagnosis is most often made during surgical resection. PMID:24717076

2014-01-01

120

Cavernous hemangioma-like Kaposi sarcoma: a unique histopathologic variant.  

PubMed

Kaposi sarcoma (KS) is an angiolymphatic neoplasm with multifactorial etiology. Clinically, KS has been divided into 4 distinct types and 3 well-defined histologic stages. Rare reports in the literature have characterized additional unique histopathologic variants. The authors report a case of KS, confirmed with human herpesvirus type 8 and D2-40 staining, which resembled a cavernous hemangioma on histopathology. PMID:24803066

Sutton, Angela M; Tarbox, Michelle; Burkemper, Nicole M

2014-05-01

121

Unstable Giants  

Microsoft Academic Search

We find giant graviton solutions in Frolov's three parameter generalization\\u000aof the Lunin-Maldacena background. The background we study has\\u000a$\\\\tilde{\\\\gamma}_1=0$ and $\\\\tilde{\\\\gamma}_2=\\\\tilde{\\\\gamma}_3=\\\\tilde{\\\\gamma}$.\\u000aThis class of backgrounds provide a non-superymmetric example of the gauge\\u000atheory\\/gravity correspondence that can be tested quantitatively, as recently\\u000ashown by Frolov, Roiban and Tseytlin. The giant graviton solutions we find have\\u000aa greater energy than the

Robert de Mello Koch; Norman Ives; Jelena Smolic; Milena Smolic

2005-01-01

122

Giant Pandas  

NSDL National Science Digital Library

The Smithsonian Institution National Zoological Park presents this extensive curriculum guide focused on the giant panda, one of the zoo's most famous denizens. Three sets of multidisciplinary lesson plans -- for grades K-4, 5-8, and 9-12 -- "contain all necessary background information and explore giant panda biology, habitat, zoo science, and conservation efforts." For example, the curriculum guide for grades 9-12 includes lesson plans addressing animal behavior and interdependence, the biomes of China, land-use planning, creative writing, and more. Students may also take advantage of the zoo's many other panda-related resources available online.

123

Intravenous lobular capillary hemangioma occurring in the cephalic vein of a 39-year-old adult.  

PubMed

Intravenous lobular capillary hemangiomas are extremely uncommon and mostly occur in the veins of the neck and upper extremities. Here, we report the clinical and sonographic features of an intravenous lobular capillary hemangioma localized in the right cephalic vein, and we discuss its pathologic findings and differential diagnoses. PMID:24151094

Ahn, Sung Eun; Park, Ji Seon; Ryu, Kyung Nam; Jin, Wook; Park, So Young

2014-01-01

124

Resolution of brachial plexus palsy due to hemangioma after intravenous corticosteroid therapy.  

PubMed

The authors report a 7-day-old girl born with a hemangioma involving the right side of the scalp and neck who developed ipsilateral brachial plexus palsy at 5 days of age. Imaging studies confirmed the presence of a cavernous hemangioma in the vicinity of the brachial plexus. She was treated with intravenous corticosteroids and her palsy resolved in 5 days. Only 1 prior case of hemangioma producing brachial plexus palsy has been reported; this patient was not treated with corticosteroids and had a partial recovery. The authors believe that the quick recovery after initiating systemic steroids was due to relief of nerve compression (neuropraxia) resulting from shrinkage of the cavernous hemangioma. The purpose of this article is to describe an uncommon cause of neonatal brachial plexus palsy and to report the effectiveness of early intravenous corticosteroid treatment in a patient with brachial plexus palsy due to a cavernous hemangioma. PMID:18660479

Naqvi, Ali H; Alfonso, Daniel T; Flores, Patricia; Grossman, John A I; Restrepo, Ricardo; Alfonso, Israel

2008-08-01

125

A practical guide to treatment of infantile hemangiomas of the head and neck  

PubMed Central

Infantile hemangiomas are the most common benign vascular tumors in infancy and childhood. As hemangioma could regress spontaneously, it generally does not require treatment unless proliferation interferes with normal function or gives rise to risk of serious disfigurement and complications unlikely to resolve without treatment. Various methods for treating infant hemangiomas have been documented, including wait and see policy, laser therapy, drug therapy, sclerotherapy, radiotherapy, surgery and so on, but none of these therapies can be used for all hemangiomas. To obtain the best treatment outcomes, the treatment protocol should be individualized and comprehensive as well as sequential. Based on published literature and clinical experiences, we established a treatment guideline in order to provide criteria for the management of head and neck hemangiomas. This protocol will be renewed and updated to include and reflect any cutting-edge medical knowledge, and provide the newest treatment modalities which will benefit our patients. PMID:24260591

Zheng, Jia Wei; Zhang, Ling; Zhou, Qin; Mai, Hua Ming; Wang, Yan An; Fan, Xin Dong; Qin, Zhong Ping; Wang, Xv Kai; Zhao, Yi Fang

2013-01-01

126

Large capillary hemangioma of the temporal bone with a dural tail sign: A case report  

PubMed Central

The present study reports a rare case of large capillary hemangioma of the temporal bone with a dural tail sign. A 57-year-old female presented with pulsatile tinnitus and episodic vertigo associated with a ten-year history of an intermittent faint headache. Magnetic resonance imaging revealed a mass in the right petrous bone, which was hypointense on T1-weighted images and heterogeneously hyperintense on T2-weighted images, and showed a dural tail sign following gadolinium administration. Pre-operatively, this tumor was believed to be a meningioma. During surgery, the vascular tumor was removed by a modified pterional approach. A histopathological examination indicated that the tumor was a capillary hemangioma. Although intraosseous capillary hemangiomas are rare, they most frequently affect the temporal bone. Hemangiomas of the temporal bone may mimic other more common basal tumors. The diagnosis is most often made during surgical resection. The dural tail sign is not specific for meningioma, as it also occurs in other intracranial or extracranial tumors. The treatment of intratemporal hemangiomas is complete surgical excision, with radiotherapy used for unresectable lesions. To the best of our knowledge, the present study is the fourth case of intraosseous intracranial capillary hemangioma, but the largest intratemporal hemangioma to be reported in the literature to date. PMID:24959241

YANG, GUANG; LI, CHENGUANG; CHEN, XIN; LIU, YAOHUA; HAN, DAYONG; GAO, XIN; KAWAMOTO, KEIJI; ZHAO, SHIGUANG

2014-01-01

127

Pure spinal epidural cavernous hemangioma with intralesional hemorrhage: a rare cause of thoracic myelopathy.  

PubMed

Although cavernous hemangiomas occur frequently in the intracranial structures, they are rare in the spine. Most of spinal hemangiomas are vertebral origin and "pure" epidural hemangiomas not originating from the vertebral bone are very rare. Our spinal hemangioma case is extremely rare because of its "pure" epidural involvement and intralesional hemorrhage. A 64-year-old man presented with progressive paraparesis from two months ago. His motor weakness was rated as grade 4/5 in bilateral lower extremities. He also complained of decreased sensation below the T4 sensory dermatome, which continuously progressed to the higher dermatome level. Magnetic resonance imaging demonstrated thoracic spinal tumor at T3-T4 level. The tumor was located epidural space compressing thoracic spinal cord ventrally. The tumor was not involved with the thoracic vertebral bone. We performed T3-5 laminectomy and removed the tumor completely. The tumor was not infiltrating into intradural space or vertebral bone. The histopathologic study confirmed the epidural tumor as cavernous hemangioma. Postoperatively, his weakness improved gradually. Four months later, his paraparesis recovered completely. Here, we present a case of pure spinal epidural cavernous hemangioma, which has intralesional hemorrhage. We believe cavernous hemangioma should be included in the differential diagnosis of the spinal epidural tumors. PMID:25110490

Jang, Donghwan; Kim, Choonghyo; Lee, Seung Jin; Ryu, Young-Joon; Kim, Jiha

2014-06-01

128

[Viral hepatitis].  

PubMed

Viral hepatitis is associated with significant morbidity and mortality worldwide. Hepatitis A and E viruses are enterally transmitted and lead to usually self-limited acute hepatitis. Hepatitis B, C and D viruses are transmitted by parenteral routes and can lead to chronic hepatitis with progression to liver cirrhosis and hepatocellular carcinoma. Here, we briefly review current understanding and new developments in the virology and epidemiology, diagnosis, natural history, therapy and prevention of viral hepatitis. PMID:21452137

Moradpour, Darius; Blum, Hubert E

2011-04-01

129

A hemangioma of the sigmoid colon mesentery presenting as a retroperitonealtumor: a case report and review  

PubMed Central

Hemangiomas of the gastrointestinal tract and mesentery are uncommon benign vascular lesions. While spontaneous bleeding is the hallmark of the gastrointestinal tumor variant, clinical signs of mesenteric hemangiomas are mostly unspecific. Despite the increasing imaging quality of computerized tomography (CT), in most cases the final diagnosis is established through surgery and histopathologic analysis of a macrobiopsy. We present a case report of a 20-year-old female patient who was admitted with progressive abdominal distension and suffered from persistent abdominal pain for 3 months. A large retroperitoneal tumor mass was detected on the CT scan. Due to radiographic signs of an intraabdominal liposarcoma, an explorative laparotomy was performed revealing a large hemangioma originating from the mesosigmoid. Although rare, gastrointestinal hemangiomas should be kept in mind by oncological visceral surgeons as one differential diagnosis of large intraabdominal tumorous masses, especially in young adults. PMID:24684941

2014-01-01

130

Laparoscopic partial resection for hemangioma in the third portion of the duodenum.  

PubMed

Benign duodenal tumors are rare and less common than malignant tumors. Furthermore, vascular lesions of the duodenum, including hemangiomas, are rare causes of gastrointestinal bleeding. This report describes a case with bleeding hemangiomas in the third portion of the duodenum and jejunum and their successful treatment using a laparoscopic approach. There is no report of totally laparoscopic resection for tumor in the third portion of duodenum. After performing a laparoscopic Kocher maneuver, the location of the duodenal hemangioma was confirmed by endoscopic and laparoscopic observation. The lesion was excised using ultrasonic coagulating shears and the defect in the duodenal wall was sutured laparoscopically. The hemangioma of the jejunum was treated extracorporeally through a 3.0 cm umbilical incision. The operating time was 241 min and blood loss was negligible. The postoperative course was uneventful. For benign duodenal tumors in the third portion, if endoscopic resection is not adapted, this less invasive technique may be a standard treatment. PMID:25232270

Kanaji, Shingo; Nakamura, Tetsu; Nishi, Masayasu; Yamamoto, Masashi; Kanemitu, Kiyonori; Yamashiita, Kimihiro; Imanishi, Tatsuya; Sumi, Yasuo; Suzuki, Satoshi; Tanaka, Kenichi; Kakeji, Yoshihiro

2014-09-14

131

A Handheld Wireless Device for Diffuse Optical Spectroscopic Assessment of Infantile Hemangiomas  

E-print Network

:1 in case of PHACES syndrome. Other identified risk factors are: race (Caucasian), prematurity, and low to years [4,5,6,7]. At the age of 5 years, 50 percent of the hemangiomas have involuted, and at the age

Hielscher, Andreas

132

Potent Inhibition of Hemangioma Formation in Rats by the Acyclic Nucleoside Phosphonate Analogue Cidofovir1  

Microsoft Academic Search

The acyclic nucleoside phosphonate analogue cidofovir elicited a marked protection against hemangioma growth in newborn rats that had been infected i.p. with a high titer of murine polyomavirus. Untreated, infected rats developed cutaneous, ¡.in., and cerebral hemangiomas asso ciated with severe hemorrhage and anemia leading to death within 3 weeks postinfection (p.i.). s.c. treatment with cidofovir at 25 mg\\/kg, once

Sandra Liekens; Gracida Andrei; Michel Vandeputte; Erik De Clercq; Johan Neyts

133

Sclerosing cavernous hemangioma of the cavernous sinus mimicking congenital fibrosis of the extraocular muscles.  

PubMed

A girl with a clinical presentation suggestive of unilateral congenital fibrosis of the extraocular muscles type 3 at 2 years of age years later developed progressive ophthalmoplegia and an afferent pupillary defect. Reimaging revealed a lesion diagnosed as a sclerosing cavernous sinus hemangioma with focal calcification. Cavernous sinus hemangioma is a rare, benign vascular malformation whose growth causes cranial nerve compression. Although frequently missed on routine neuroimaging, characteristic radiologic findings distinguish it from lesions such as meningioma. PMID:24751811

Gesite-de Leon, Bhambi; Demer, Joseph L

2014-06-01

134

Giant Food, Inc  

Microsoft Academic Search

Giant Food, an innovator in grocery retailing, is leading the industry in the introduction of optical-scanning computer-assisted checkout systems. To gain cost savings from the system, Giant is attempting to eliminate item pricing. Consumer groups and the Maryland State Legislature are opposing Giant's efforts to implement the change. However, consumers and Giant employees appear to be responding positively to the

Ralph Biggadike; Andrea Levin; Eleanor May

135

Preliminary Report On Combined Surgical- And Laser-Treatment Of Large Hemangiomas And Tattoos  

NASA Astrophysics Data System (ADS)

As most hemangiomas and tattoos require many sessions to be cured completely by argon-laser or conventional therapy I developed a new combined surgical and laser-therapy method for large hemangiomas and tattoos. This is a three step method. First: The skin lesion is treated by argon-laser with the point by point method, developed by ourself. Second: Under local or general anaesthesia a) the hemangioma is partially excised and undermined letting only the skin which is already treated by argon-laser-beams. Than the hemangioma is exstirpated in toto, the wound closed by running intradermal sutures and a pressure bandage applied, b) the tattoo is abraded as deep as possible, draped by lyofoam. Then a pressure bandage is applied. Third: The hemangioma as well as the tattoo are treated by argon-laser-beams after the operation. This method is safe and effective, gives good results, minimal scars in the case of hemangiomas and tattoos. In this paper the method is described and some cases are illustrated by pre- and postoperational photographs.

Ginsbach, G.

1981-05-01

136

Hemangioma of the prostate - an unusual cause of lower urinary tract symptoms: Case report  

PubMed Central

Background Hemangioma of the prostate gland is extremely rare and only a few cases have been reported. There have been several cases of hemangioma of posterior urethra, urinary bladder and periprostatic plexus in the literature, all presenting with hematuria or hematospermia. Diagnosis of prostatic hemangioma is difficult due to its rarity and unspecific symptoms such as hematuria, hematospermia or lower urinary tract symptoms. It cannot be detected by conventional examinations such as cystoscopy or standard rectal ultrasonography. Case presentation We present a case of prostatic hemangioma in an 84-year old male presenting with lower urinary tract symptoms. Bleeding has not been a feature in our case and diagnosis was not made until after operation. The patient was treated as a case of bladder neck outflow obstruction with transurethral resection of prostate gland and simultaneous bladder neck incisions. A period of self-catheterization was instituted due to postoperative urinary retention as the result of detrusor insufficiency. Conclusion Hemangioma of prostate gland is extremely rare and symptomatic prostatic hemangioma should be treated either by transurethral resection of prostate or laser evaporation. PMID:21486499

2011-01-01

137

Coexistence of cavernous hemangioma and other vascular malformations of the orbit. A report of three cases.  

PubMed

Coexistence of orbital cavernous hemangioma and other vascular malformations is unusual and few cases have been reported. We describe the clinical and radiological features of three cases of orbital cavernous hemangiomas associated with other vascular malformations, selected reviewing a series of 181 cases of cavernous hemangiomas. All patients were males (age ranging from 43 to 67 years) without vascular systemic disorders and/or a clinical syndrome. They experienced slow progressive exophthalmos. One of them developed acute pulsatile proptosis (case 2), while another experienced slow progressive diplopia (case 3). In one case vascular lesions were bilateral (case 3) and in two patients two different lesions coexisted in the same orbit (cases 1 and 2). All patients underwent surgical excision, which was partial in two cases. Two patients had cavernous hemangiomas in association with a venous malformation (a varix in case 1 and a lymphangioma in case 2), while in the other ones (case 3) cavernous hemangioma was associated with a low-flow arteriovenous malformation. No patient denied visual impairment postoperatively. Few cases of orbital cavernous hemangiomas coexisting with other vascular malformations have been reported in the literature. This entity seems to be an association of different variants of orbital vascular malformations, presenting with a wide spectrum of clinical forms and probably with the same pathogenesis. PMID:24750713

Strianese, Diego; Napoli, Manuela; Russo, Carmela; D'Errico, Arianna; Scotti, Nadia; Puoti, Gianfranco; Bonavolontà, Giulio; Tranfa, Fausto; Briganti, Francesco

2014-04-01

138

Giant pilomatricoma.  

PubMed

A 52-year-old man was examined for an ulcerated, rapidly growing reddish nodule. It was 5.5 cm high with an 11 x 6-cm base and located on the left clavicle. The lesion had been present for approximately 7 years, and the patient complained occasional burning and pain. Clinical differential diagnoses included cutaneous lymphoma, sarcoma, squamous cell carcinoma, and cutaneous metastasis. Histopathologic examination revealed a well-circumscribed tumor involving the whole dermis and the subcutis and composed of partially confluent aggregates of matrical cells admixed with eosinophilic cornified material containing shadow cells. In addition, multinucleated giant cells, areas of calcification and metaplastic ossification, edema, and hemorrhage were also observed. On the basis of histopathologic features, the diagnosis of pilomatricoma was made. Our report highlights an unusual clinical appearance of pilomatricoma that made us consider a variety of primary or secondary cutaneous neoplasms in its differential diagnosis. PMID:17519628

Lozzi, Gian Piero; Soyer, H Peter; Fruehauf, Julia; Massone, Cesare; Kerl, Helmut; Peris, Ketty

2007-06-01

139

Poland syndrome (anomaly) with congenital hemangioma: a new association.  

PubMed

Unilateral defect of pectoral muscle and ipsilateral syndactyly constitute Poland syndrome. Absence or hypoplasia of the breast and nipple, axillary hair loss and dermatoglyphic abnormalities have also been reported in this syndrome. The primary defect could be in the development of the proximal subclavian artery with early deficit of blood flow to the distal limb and the pectoral region, resulting in partial loss of tissue in those regions. However, the association of congenital hemangioma with Poland sequence has not been observed so far. Such an association is being reported here in a 1-year-old infant, second-born of nonconsanguineous parents, who also had polydactyly instead of the documented syndactyly. PMID:16766839

Riyaz, Najeeba; Riyaz, A

2006-01-01

140

An Unusual Presentation of Giant Cell Arteritis  

PubMed Central

Giant cell arteritis (GCA) is a chronic vasculitis that typically presents with headache, fever and polymyalgia although atypical presentations are known. We present a case of GCA with nonproductive cough and pyrexia of unknown origin emphasizing this atypical nature of presentation. We report a rare association of GCA with granulomatous hepatitis. We also support the use of PET scanning in diagnosing and monitoring this condition. PMID:22811725

Prabhavalkar, Siddhesh; Bogusz, Pawel; Merard, Reena; Gormley, Mark

2012-01-01

141

Hepatitis C  

MedlinePLUS Videos and Cool Tools

... been successful in keeping the virus in check. Women who have hepatitis C should check with their ... who share needles or razors • babies born to women who have hepatitis C Prevention Since treatment for ...

142

Autoimmune Hepatitis  

MedlinePLUS

... with type 1 autoimmune hepatitis commonly have other autoimmune disorders, such as celiac disease, an autoimmune disease in ... 2 can also have any of the above autoimmune disorders. [ Top ] What are the symptoms of autoimmune hepatitis? ...

143

Hepatitis A  

MedlinePLUS

... an inflammation of the liver. One type, hepatitis A, is caused by the hepatitis A virus (HAV). The disease spreads through contact with ... washed in untreated water Putting into your mouth a finger or object that came into contact with ...

144

Hepatitis C  

MedlinePLUS

... Philadelphia, Pa: Elsevier Saunders; 2010:chap 79. Rosen HR. Clinical practice. Chronic hepatitis C infection. N Engl J Med . 2011;364(25):2429-38. Moyer VA; U.S. Preventive Services Task Force. Screening for hepatitis C virus infection ...

145

Major hepatic resection. A 25-year experience.  

PubMed

Major hepatic resections were performed on 138 patients for a variety of conditions. There was one intraoperative death. Including this patient, there were 15 deaths within 30 days of the operation (operative mortality 10.9%). Important postoperative complications were intra-abdominal sepsis (17%), biliary leak (11%), hepatic failure (8%), and hemorrhage (6%). The results of 30 resections for the benign lesions, liver cell adenoma, focal nodular hyperplasia, hemangioma, and cystadenoma showed no operative mortality and low morbidity. Of 26 patients with hepatocellular carcinoma, seven died within a month of operation. The cumulative survival of the 26 at five years was 38%, and of the 19 who survived the procedure, 51%. Poor survival followed resections for cholangiocarcinoma and "mixed tumors." The five-year cumulative survival of 22 patients who had colorectal metastases excised was 31%. Apart from a patient with carcinoid, prolonged survival was rare after resection of other secondaries and after en bloc resections for tumors directly invading the liver. Hepatic resection was of value in the management of some patients with hepatic trauma, Caroli's disease, liver cysts, and intrahepatic stones. PMID:6299217

Thompson, H H; Tompkins, R K; Longmire, W P

1983-04-01

146

Severe progressive scoliosis due to huge subcutaneous cavernous hemangioma: A case report  

PubMed Central

Cavernous hemangioma consists mainly of congenital vascular malformations present before birth and gradually increasing in size with skeletal growth. A small number of patients with cavernous hemangioma develop scoliosis, and surgical treatment for the scoliosis in such cases has not been reported to date. Here we report a 12-year-old male patient with severe progressive scoliosis due to a huge subcutaneous cavernous hemangioma, who underwent posterior correction and fusion surgery. Upon referral to our department, radiographs revealed a scoliosis of 85° at T6-L1 and a kyphosis of 58° at T4-T10. CT and MR images revealed a huge hemangioma extending from the subcutaneous region to the paraspinal muscles and the retroperitoneal space and invading the spinal canal. Posterior correction and fusion surgery using pedicle screws between T2 and L3 were performed. Massive hemorrhage from the hemangioma occurred during the surgery, with intraoperative blood loss reaching 2800 ml. The scoliosis was corrected to 59°, and the kyphosis to 45° after surgery. Seven hours after surgery, the patient suffered from hypovolemic shock and disseminated intravascular coagulation due to postoperative hemorrhage from the hemangioma. The patient developed sensory and conduction aphasia caused by cerebral hypoxia during the shock on the day of the surgery. At present, two years after the surgery, although the patient has completely recovered from the aphasia. This case illustrates that, in correction surgery for scoliosis due to huge subcutaneous cavernous hemangioma, intraoperative and postoperative intensive care for hemodynamics should be performed, since massive hemorrhage can occur during the postoperative period as well as the intraoperative period. PMID:21414205

2011-01-01

147

Hepatitis C  

MedlinePLUS

... an inflammation of the liver. One type, hepatitis C, is caused by the hepatitis C virus (HCV). It usually spreads through contact with ... childbirth. Most people who are infected with hepatitis C don't have any symptoms for years. If ...

148

Giant Cell Arteritis  

MedlinePLUS

Giant cell arteritis is a disorder that causes inflammation of arteries of the scalp, neck, and arms. It narrows ... arteries, which keeps blood from flowing well. Giant cell arteritis often occurs with another disorder called polymyalgia ...

149

Giant Cell Arteritis  

MedlinePLUS

... polymyalgia rheumatica (also called PMR). What is giant cell arteritis? GCA is a type of vasculitis or ... right away to their doctors. What causes giant cell arteritis? As with PMR, the cause of GCA ...

150

Giant congenital nevus  

MedlinePLUS

... hairy nevus; Giant pigmented nevus; Bathing trunk nevus; Congenital melanocytic nevus - large ... cells (lipomas) Neurofibromatosis Other nevi Spina bifida Smaller ... cause problems most of the time. Larger or giant nevi are rare.

151

Low Concentration of Rapamycin Inhibits Hemangioma Endothelial Cell Proliferation, Migration, and Vascular Tumor Formation in Mice  

PubMed Central

Background Vascular endothelial cell excessive proliferation is the main biological behavior of hemangioma. Rapamycin regulates the growth of endothelial cells by inhibiting mammalian target of rapamycin (mTOR). Thus hemangioma accompanied by excessive mTOR activation should be sensitive to rapamycin. We aimed to illustrate the effect of low-concentration rapamycin on hemangioma and provide a safe and effective drug therapy. Methods Mouse hemangioendothelioma endothelial cells and Nu/Nu mice were used. Rapamycin was applied in a concentration from 1 nM to 20 nM. WST-1 cell proliferation and transwell migration assays were used to analyze vascular tumor proliferation and migration in vitro. Xenograft mouse models were used to test vascular tumor growth in vivo. Results Low-concentration rapamycin (1 nM) inhibited hemangioendothelioma endothelial cell proliferation and migration in vitro and vascular tumor growth in vivo. The mechanism was decreased activation of the protein kinase B/mTOR/S6 ribosomal protein (S6) signaling pathway. Conclusions Rapamycin used in vitro was analogous to low serum concentration rapamycin (7–16 nM) and also significantly inhibited the growth of hemangioma. These results demonstrate a low-toxic drug therapy for hemangioma and encourage continued development of rapamycin and its analogs for use in vascular tumor therapy.

Zheng, Ningning; Ding, Xudong; Jahan, Rabita

2014-01-01

152

Capillary hemangioma as a rare benign tumor of the oral cavity: a case report  

PubMed Central

Introduction Hemangioma is a relatively common benign proliferation of blood vessels that primarily develops during childhood. Two main forms of hemangioma recognized: capillary and cavernous. The capillary form presents as a flat area consisting of numerous small capillaries. Cavernous hemangioma appears as an elevated lesion of a deep red color, and consists of large dilated sinuses filled with blood. The purpose of the study was to report the case of a capillary hemangioma in a patient and to describe the successful treatment of this case. Case presentation The patient was a 19-year-old female who presented herself to the Atatürk University, Faculty of Dentistry, Department of Periodontology, with the complaint of bleeding and slowly enlarging mass on the upper right molar region. The lesion was diagnosed as capillary hemangioma after clinical examination and biopsy. Treatment consisted of scaling, root planning and surgical excision. Four months after surgery healing was occurred and two years later area of the lesion appeared completely normal as clinically. Conclusions The surface is highly keratinized and no further growth was evidenced during the two year of follow-up. Early detection and biopsy is necessary to determine the clinical behavior of the tumor and potential dentoalveolar complications. PMID:20181211

2009-01-01

153

Glomeruloid hemangioma in POEMS syndrome: a report on two cases and a review of the literature.  

PubMed

Glomeruloid hemangioma is characterized by coiled capillary vessels contained within enlarged vascular spaces displaying an architecture that resembles renal glomeruli. The condition is strongly associated with POEMS syndrome (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy and Skin changes). The present paper reports on two cases of glomeruloid hemangiomas associated with POEMS syndrome, and includes a review of the literature. Case one refers to a 63-year old female patient admitted to hospital with ascites, hepatosplenomegaly, walking difficulties and cutaneous hemangiomas. Histopathology revealed a diagnosis of glomeruloid hemangioma and served to guide the clinical work-up, which revealed sensorimotor polyneuropathy, a plasmacytoma in the L4 vertebra with tumor cells positive for kappa chain, and diabetes mellitus. These findings permitted a diagnosis of POEMS syndrome to be reached. The second case consisted of a 39-year old woman admitted to hospital with edema, ascites, pleural effusion, glomeruloid hemangiomas and lymphadenopathy (Castleman's disease). Additional findings included monoclonal IgG-lambda paraproteinemia, blastic lesions in the right iliac bone and L4 vertebra, and demyelinating sensorimotor neuropathy affecting all four limbs. The final diagnosis in this case was POEMS syndrome associated with Castleman's disease. PMID:22281906

Jeunon, Thiago; Sampaio, Ana Luisa Bittencourt; Caminha, Ricardo C; Reis, Carlos Umberto da Cunha; Dib, Cassio

2011-01-01

154

Spectral domain optical coherence tomography guided photodynamic therapy for choroidal hemangioma: a case report  

PubMed Central

Introduction Circumscribed choroidal hemangiomas are vascular tumors associated with secondary changes in the overlying retinal pigment epithelium and neuro-sensory retina. Spectral-domain optical coherence tomography, a recent advancement in fundus imaging techniques provides high resolution images of the retina. We describe spectral domain Optical coherence tomography findings in a case of circumscribed choroidal hemangioma which was successfully treated with photodynamic therapy. Case presentation A 41-year-old white male presented with decreased vision in his right eye. Fundus evaluation showed findings consistent with circumscribed choroidal hemangioma. Spectral-domain optical coherence tomography revealed a large serous retinal detachment overlying the tumor with an intact photoreceptor layer. The patient underwent photodynamic therapy and a repeat tomography scan confirmed the resolution of serous detachment with return of normal foveal contour. Conclusion Spectral domain optical coherence tomography is an emerging modality in imaging of the retina and reveals ultrastructural changes occurring in various retina pathologies. In this case report we illustrate the use of spectral domain optical coherence tomography for the first time to document retinal changes overlying a choroidal hemangioma and its role as a non-invasive tool in planning the treatment and prognosticating the final visual outcome following treatment for circumscribed subfoveal choroidal hemangiomas. PMID:20184695

2009-01-01

155

Theory of Giant Planets  

Microsoft Academic Search

Giant planet research has moved from the study of a handful of solar system objects to that of a class of bodies with dozens of known members. Since the original 1995 discovery of the first extrasolar giant planets (EGPs), the total number of known examples has increased to ~80 (circa November 2001). Current theoretical studies of giant planets emphasize predicted

W. B. Hubbard; A. Burrows; J. I. Lunine

2002-01-01

156

Giant impacts on giant planets  

NASA Astrophysics Data System (ADS)

The 2009 impact and recent superbolides on Jupiter caught the world by surprise and cast doubt on impactor flux estimates for the outer solar system. Enhanced amateur planetary imaging techniques yield both high spatial resolution (enabling the 2009 impact debris field detection) and rapid frame rates (enabling the 2010/2012 impact flash detections and lightcurve measurements).We propose a ToO program to image future impacts on Jupiter and Saturn. To remove the possibility of impact cloud non-detections, the program will be triggered only if an existing impact debris field is seen, an object on a collision course with Jupiter or Saturn is discovered, or an impact light curve is measured with an estimated total energy large enough to generate an impact cloud in a giant planet atmosphere (10^20 J).HST provides the only way to image these events in the ultraviolet, providing information on aerosol altitudes and on smaller particles that are less visible to ground-based infrared observations. High-resolution imaging with proper timing (not achievable from the ground) is required to measure precisely both the velocity fields of impact sites and the optical spectrum of impact debris. HST observations of past impacts on Jupiter have also served both as cornerstones of science investigations at other wavelengths and as vehicles for effective public outreach.Large outer solar system impacts are governed by the same physics as in the terrestrial events that dominate the impact threat to humans. Studying the behavior of impactors of various sizes and compositions, as they enter the atmosphere at varying angles and speeds, will better quantify terrestrial impact hazards.

de Pater, Imke

2014-10-01

157

Giant impacts on giant planets  

NASA Astrophysics Data System (ADS)

The 2009 impact on Jupiter caught the world by surprise and cast doubt on impactor flux estimates for the outer solar system. Enhanced amateur planetary imaging techniques yield both high spatial resolution {enabling the 2009 impact debris field detection} and rapid frame rates {enabling the 2010 impact flash detections and lightcurve measurements}.We propose a Target of Opportunity program to image future impacts on Jupiter and Saturn. To remove the possibility of impact cloud non-detections, the program will be triggered only if an existing impact debris field is seen, an object on a collision course with Jupiter or Saturn is discovered, or an impact light curve is measured with an estimated total energy large enough to generate an impact cloud in a giant planet atmosphere.HST provides the only way to image these events in the ultraviolet, providing information on aerosol altitudes and on smaller particles that are less visible to ground-based infrared observations. High-resolution imaging with proper timing {not achievable from the ground} is required to measure precisely both the velocity fields of impact sites and the optical spectrum of impact debris. HST observations of past impacts on Jupiter have also served both as cornerstones of science investigations at other wavelengths and as vehicles for effective public outreach.Large outer solar system impacts are governed by the same physics as in the terrestrial events that dominate the impact threat to humans. Studying the behavior of impactors of various sizes and compositions, as they enter the atmosphere at varying angles and speeds, will better quantify terrestrial impact hazards.

de Pater, Imke

2012-10-01

158

Giant impacts on giant planets  

NASA Astrophysics Data System (ADS)

The 2009 impact and recent superbolides on Jupiter caught the world by surprise and cast doubt on impactor flux estimates for the outer solar system. Enhanced amateur planetary imaging techniques yield both high spatial resolution {enabling the 2009 impact debris field detection} and rapid frame rates {enabling the 2010/2012 impact flash detections and lightcurve measurements}.We propose a ToO program to image future impacts on Jupiter and Saturn. To remove the possibility of impact cloud non-detections, the program will be triggered only if an existing impact debris field is seen, an object on a collision course with Jupiter or Saturn is discovered, or an impact light curve is measured with an estimated total energy large enough to generate an impact cloud in a giant planet atmosphere {10^20 J}.HST provides the only way to image these events in the ultraviolet, providing information on aerosol altitudes and on smaller particles that are less visible to ground-based infrared observations. High-resolution imaging with proper timing {not achievable from the ground} is required to measure precisely both the velocity fields of impact sites and the optical spectrum of impact debris. HST observations of past impacts on Jupiter have also served both as cornerstones of science investigations at other wavelengths and as vehicles for effective public outreach.Large outer solar system impacts are governed by the same physics as in the terrestrial events that dominate the impact threat to humans. Studying the behavior of impactors of various sizes and compositions, as they enter the atmosphere at varying angles and speeds, will better quantify terrestrial impact hazards.

de Pater, Imke

2013-10-01

159

Percutaneous vertebroplasty in symptomatic hemangioma versus osteoporotic compression fracture  

PubMed Central

Background: Percutaneous vertebroplasty (PVP) is more commonly used for osteoporotic compression fractures (OCFs) and osteolytic vertebral body tumors. This study aimed to study the differences between OCFs and vertebral hemangiomas (VHs) treated with PVP. Materials and Methods: Between September 2007 and January 2010, we prospectively treated 28 consecutive patients of OCFs (43 recently symptomatic OCFs) and 24 cases of VHs (26 VHs). We used visual analogue scale (VAS) pain and Oswestry Disability Index (ODI) to evaluate the patients. The followup period in group 1 and 2 were 25.1 months (range 12 - 31 months) and 21.3 months (range 14 - 28 months), respectively. Comparison of means was carried out with the Chi Square Tests, t-test, and N Par-Test for multiple comparisons, whenever appropriate. The level of statistical significance was set at P < 0.05. Results: Following PVP the VAS score decreased to 4.57 and 4.17 in group 1 and 2, respectively. The ODI scores were 32.5% and 30%, respectively. This decrease in ODI scores lasted throughout the followup period. Conclusions: Although the preoperative scores were significantly different between group 1 and 2, there was no significant difference between two groups following the PVP. PMID:23798752

Omidi-Kashani, Farzad; Hasankhani, Ebrahim G; Akhlaghi, Saeed; Golhasani-Keshtan, Farideh; Toosi, Katayoun Z

2013-01-01

160

Late rebound of infantile hemangioma after cessation of oral propranolol.  

PubMed

Propranolol has become the first line of treatment for infantile hemangiomas (IHs), with a high response rate, but rebound growth after cessation of propranolol has been reported, primarily in the first year of life. We sought to determine the frequency and associated factors leading to late regrowth after successful treatment at an age when the proliferative phase has usually ceased. We retrospectively reviewed the clinical charts, serial photographs, and radiologic images of children with rebound IH occurring after the age of 15 months after a successful course of oral propranolol averaging 2.6 mg/kg/day (range 2-3 mg/kg/day). Thirteen (10 female, 3 male) of 212 patients (6%) treated with oral propranolol since 2008 were evaluated. The mean age at the start of treatment was 5.3 months (range 1.8-13 months), and an average of 10.3 months (range 4.5-16 months) of treatment was given. It took an average of 5.3 months (range 1-13.8 months) for a significant rebound to appear. Late rebound after successful propranolol indicates a prolonged proliferation phase of IH even after 15 months of age. This is compared with previous reports of rebound, which occurred primarily in infants younger than 1 year old. Late proliferation can occur in localized, small, mixed, and deep IH, even after several months of a positive response to propranolol. A second course of propranolol readily controlled the recurrence. PMID:24016283

Shehata, Nancy; Powell, Julie; Dubois, Josée; Hatami, Afshin; Rousseau, Elizabeth; Ondrejchak, Sandra; McCuaig, Catherine

2013-01-01

161

Cavernous sinus hemangioma: a fourteen year single institution experience.  

PubMed

Cavernous sinus hemangioma (CSH) is a rare extra-axial vascular neoplasm that accounts for 2% to 3% of all cavernous sinus tumors. Their location, propensity for profuse bleeding during surgery, and relationship to complex neurovascular structures are factors which present difficulty in excising these lesions. The authors describe their experience of 22 patients with CSH over 14 years at a tertiary care center. Patients were managed with microsurgical resection using a purely extradural transcavernous approach (13 patients) and with Gamma Knife radiosurgery (GKRS; Elekta AB, Stockholm, Sweden) (nine patients). Retrospective data analysis found headache and visual impairment were the most common presenting complaints, followed by facial hypesthesia and diplopia. All but one patient had complete tumor excision in the surgical series. Transient ophthalmoparesis (complete resolution in 6-8 weeks) was the most common surgical complication. In the GKRS group, marked tumor shrinkage (>50% tumor volume reduction) was achieved in two patients, slight shrinkage in five and no change in two patients, with symptom improvement in the majority of patients. To our knowledge, we describe one of the largest series of CSH managed at a single center. Although microsurgical resection using an extradural transcavernous approach is considered the treatment of choice in CSH and allows complete excision with minimal mortality and long-term morbidity, GKRS is an additional tool for treating residual symptomatic lesions or in patients with associated comorbidities making surgical resection unsuitable. PMID:24524951

Bansal, Sumit; Suri, Ashish; Singh, Manmohan; Kale, Shashank Sharad; Agarwal, Deepak; Sharma, Manish Singh; Mahapatra, Ashok Kumar; Sharma, Bhawani Shankar

2014-06-01

162

Unusual Presentation of an Intraosseous Hemangioma of the Maxilla and Displaced Canine  

PubMed Central

ABSTRACT Intraosseous hemangiomas are benign vascular malformations which are extremely rare in the maxilla, but have been reported in the mandible, zygoma and orbital region. A 12 years old female presented to the oral and maxillofacial department with an ectopically positioned upper left canine in her zygomatic bone and buccal alveolar expansion between the upper left lateral incisor and upper left first premolar. This case shows the unusual presentation of an intraosseous hemangioma associated with an ectopically migrated upper left canine tooth. It is possible that this lesion caused migration of the tooth. The clinician should be aware of the possibility of this lesion for bony expansile lesions and the importance of radiographic examination in patients who present with delayed eruption of canine teeth. How to cite this article: Kalsi H, Scannell J. Unusual Presentation of an Intraosseous Hemangioma of the Maxilla and Displaced Canine. Int J Clin Pediatr Dent 2013;6(2):124-126. PMID:25206206

Scannell, Jolie

2013-01-01

163

Hemangioma of penile urethra--treatment with simple transurethral excision: a case report  

PubMed Central

Urethral hemangiomas are rare benign vascular tumors with varying size and usually present as urethral bleeding and/ or hematuria. Treatment depends on the size and site of the lesion. We present a 27 year old male with a two year history of intermittent episodes of urethral bleeding. Cystourethroscopy showed a solitary hemangioma in the penile urethra. The patient was treated with simple transurethral excision with the biopsy forceps. The catheter was removed 48 hours later. He remains symptom free four months later. Simple excision of small hemangiomas may be an effective treatment especially for young patients in order to avoid the side effects of diathermy and when facilities such is laser are not available. PMID:19829771

Kavouras, Diamantis; Vasilakis, Panagiotis; Katsanis, Spiridon

2009-01-01

164

Endoscopic bimanual approach to an intraconal cavernous hemangioma of the orbital apex with vascularized flap reconstruction.  

PubMed

The aim of this study was to describe a transnasal endoscopic bimanual technique for the removal of an intraconal orbital apex cavernous hemangioma. Report of a surgical technique. A 39-year-old woman with unilateral visual loss and proptosis was found to have an intraconal orbital apex mass consistent radiographically with cavernous hemangioma. Because of its posteromedial location within the orbit, a transnasal 4-handed endoscopic technique was used with pedicled nasoseptal flap reconstruction. The tumor was excised, and the patient had no complications. The transnasal endoscopic approach to orbital apex cavernous hemangioma excision is a viable surgical approach for these difficult to access lesions. The medial orbital wall may be simultaneously reconstructed to prevent diplopia and enophthalmos. PMID:24833438

Healy, David Y; Lee, N Grace; Freitag, Suzanne K; Bleier, Benjamin S

2014-01-01

165

Rare Benign Entities of the Breast - Myoid Hamartoma and Capillary Hemangioma  

PubMed Central

Hamartomas can occur in different areas of the breast, but they are rarely found in the breast. Myoid hamartomas with smooth muscle cells of the type described here are particularly unusual. The pathogenesis of this benign entity with its tendency to growth and recurrence is not clear. Excision is the therapy of choice. Capillary hemangiomas are rare vascular malformations of the breast which, in contrast to cavernous hemangiomas, usually remain clinically occult. It is important to differentiate these benign findings from malignant angiosarcoma. The possible heterogeneities between myoid hamartoma and capillary hemangioma using current breast imaging methods for the differential diagnosis (high-resolution ultrasound, duplex sonography, shear wave elastography, digital mammography, minimally invasive intervention) are discussed together with an overview of the literature.

Schafer, F. K.; Biernath-Wuepping, J.; Eckmann-Scholz, C.; Order, B. M.; Mathiak, M.; Hilpert, F.; Strauss, A.; Jonat, W.; Schafer, P. J.

2012-01-01

166

131I Uptake in Intraosseous Hemangioma of the Skull: Mimicking a Bone Metastasis in Thyroid Cancer.  

PubMed

We report a case of unusual I uptake in the skull in a patient who received total thyroidectomy and cervical lymph node dissection for papillary thyroid carcinoma. This uptake mimicked a bone metastasis on posttherapeutic I whole-body scan. The lesion was further evaluated by I SPECT/CT and MRI, and it was identified as intraosseous hemangioma. For the prevention of unnecessary repeat ablation therapies and physicians' confusion, the nuclear medicine physicians have to consider the I accumulation in the skull intraosseous hemangioma as a possible cause of false-positive uptake. PMID:24978336

Lee, Minkyung; Lee, Yu Kyung; Jeon, Tae Joo; Park, Cheong Soo; Ryu, Young Hoon

2014-11-01

167

An unusual cause of dyspnea in a pregnant woman: supraglottic hemangioma.  

PubMed

Dyspnea is a common complaint among pregnant women; upper airway obstruction is a rare cause of it. We report a case of supraglottic hemangioma in a 20-year-old pregnant woman who presented with increasing dyspnea and hoarseness at 40 weeks of gestation. She gave birth to a healthy 3,100-g girl by caesarean delivery under epidural anesthesia. She was able to breathe easily during the postpartum period. This case represents a rare instance of dyspnea caused by a supraglottic hemangioma in a pregnant woman. PMID:25181668

Kurdoglu, Zehra; Kurdoglu, Mertihan; Cankaya, Hakan

2014-08-01

168

Meningitis and pneumococcal pyomyositis in a child with intramuscular hemangiomas: an autopsy case report  

PubMed Central

Pyomyositis is the bacterial infection of skeletal muscle, usually accompanied by abscesses. The main etiologic agent is Staphylococcus aureus. There are rare cases attributed to Streptococcus pneumoniae. This paper presents an autopsy of a four year old child with multiple congenital intramuscular hemangiomas that developed pneumococcal pyomyositis associated with meningitis. The authors propose the hypothesis that patients with hemangiomas, mainly the intramuscular type, may also represent a risk group for pyomyositis. The possibility of respiratory/meningeal co-infection, might also be considered even if the clinical picture is restricted to the muscular system. PMID:25120847

Oliveira, Cristiano Claudino; Marques, Mariangela Esther Alencar

2014-01-01

169

[Prenatal diagnosis of hepatic hemangioendothelioma and peripartual management].  

PubMed

Infantile hepatic hemangioendothelioma is a benign hepatic tumor that can be associated with life-threatening perinatal complications. A 38-year-old gravida 3 para 2 was referred to our hospital with preterm labor at 33.6 gestational weeks. Fetal abdominal circumference was estimated sonographically above the 97 th percentile. Because of pathologic CTG, the fetus was delivered by caesarean section (APGAR-scores 0/0/7, pH: 7.15). After cardiopulmonary reanimation and intensive care of the fetus, the prenatally suspected hemangioma of the liver was confirmed by computer tomography. The day after, liver segments V, VI, and VII were resected because of lung compression. During the operation, reanimation was necessary two more times. Two days later, ductus arteriosus Botalli was occluded. After stabilization, the neonate was treated with prednisone because of tumor residues. If a large hyperechogenic mass in the fetal liver is seen prenatally, diagnosis of fetal hemangioma should be considered. In order to prevent serious cardiovascular complications, continual clinical surveillance is indicated. PMID:12649784

Ritter, S; Jörn, H; Ahaus, M; Rath, W

2003-01-01

170

Identification of Serum Regression Signs in Infantile Hemangioma  

PubMed Central

Vessel proliferation underlies a number of serious pathological conditions. Infantile Hemangioma (IH) is a low-aggressive vascular tumor, interesting as an in vivo model of spontaneous tumor regression. Identifying mechanisms underlying IH spontaneous regression may then help to elucidate vessel-growth control, strongly deregulated in other serious conditions such as sarcoma, melanoma, diabetic retinopathy. The present study was aimed at identifying early regression indicators within hematological parameters. Thirty-four blood samples were collected from IH diagnosed babies (20-months median age), spontaneously regressing with age. Nineteen serum standard blood-tests were carried out using diagnostic reagents; in addition, serum-expression of 27 cytokine/chemokines was measured. Samples were divided in three age-groups, namely ?12, 13 to 24 and >24 months-age, respectively. Red-cells count, Hemoglobin, Hematocrit, Neutrophils, Lymphocytes, MCP-1 and MIP-1beta were significantly different in the three age-groups, according to one-way ANOVA analysis. The same parameters showed a significant Pearson-correlation with age, supporting the direct link of age with IH-regression. ROC analysis showed that red-cells count, Hemoglobin, Hematocrit, MCP-1 and MIP-1beta levels significantly discriminate IH in the proliferating-phase from IH in the regressing-phase. Such data indicate for the first time that standard hematological tests and cytokine serum-expression values may effectively discriminate proliferating- from regressing-IH, unrevealing early regression signs, and demonstrate that standard blood-tests may have novel unsuspected diagnostic/prognostic relevance in altered vessel-growth conditions. PMID:24599340

Rossi, Stefania; Giampietri, Claudia; Facchiano, Francesco; Facchiano, Antonio

2014-01-01

171

Infantile Perianal Pyramidal Protrusion with Coexisting Perineal and Perianal Hemangiomas: A Fortuitous Association or Incomplete PELVIS Syndrome?  

PubMed Central

Two cases of infantile perianal pyramidal protrusions (IPPP), one pyramidal in shape and one leaf shaped, are being described by us. Both were notable for coexisting hemangiomas in the close vicinity. To the best of our knowledge we are reporting these two variants of IPPP with the associated neighboring hemangiomas for the first time in Indian dermatologic literature. We suggest that this presentation may be a part of one of the syndromes that comprise anorectal malformations with hemangiomas like PELVIS syndrome and others mentioned in the table. PMID:24470664

Verma, Shyam B; Wollina, Uwe

2014-01-01

172

Familial Segregation of Hemangiomas and Vascular Malformations as an Autosomal Dominant Trait  

Microsoft Academic Search

Background: The pathogenesis of infantile hemangio- mas is not yet understood. Growth factors and hor- monal and mechanical influences have been thought to affect the focal abnormal growth of endothelial cells in these lesions. However, these influences may represent secondary responses to an underlying primary molecu- lar event leading to the development of hemangiomas. Observations: We report the rare familial

Francine Blei; Jeffrey Walter; Seth J. Orlow; Douglas A. Marchuk

1998-01-01

173

Choroidal thickness changes with photodynamic therapy for a diffuse choroidal hemangioma in Sturge–Weber syndrome.  

PubMed

The aim of this study was to evaluate the choroidal thickness (CT) changes associated with visual function following photodynamic therapy (PDT) for a diffuse choroidal hemangioma in Sturge–Weber syndrome. We report a case of Sturge–Weber syndrome and symptomatic serous retinal detachment (SRD) with diffuse choroidal hemangioma treated with PDT. Visual acuity (VA), macular sensitivity measured by means of MP1 microperimeter (Nidek Technologies, Padova, Italy), retinal and CT, measured by means of enhanced depth optical coherence tomography (EDI–OCT, Spectralis, Heidelberg Engineering, Heidelberg, Germany) were analyzed at baseline, 3 and 12 months follow-up.After the PDT VA and macular sensitivity improved.The OCT examination showed the resolution of SRD. The choroid was measured after PDT using EDI–OCT. At baseline, the subfoveal CT showed a progressive thickness reduction from 251 to 83 lm during follow-up. To our knowledge, this is the first report of CT changes after PDT for a diffuse choroidal hemangioma in Sturge–Weber syndrome in a longterm follow-up. The CT measurement represents a potential parameter to better follow choroidal hemangiomas and their response to treatment. However,the long-term choroidal changes should be carefully taken into account. PMID:24658736

Cacciamani, Andrea; Scarinci, Fabio; Parravano, Mariacristina; Giorno, Paola; Varano, Monica

2014-10-01

174

Acquired capillary hemangioma of the eyelid in a 49-year-old woman from Turkey  

PubMed Central

A 49-year-old woman developed a dark brown nodular mass in the lower eyelid. The lesion had grown fast for 2 months and then had remained stable in size. Excisional biopsy was performed. Histopathological examination of an excisional biopsy specimen pointed to proliferative vessels lined by increased endothelial cells without nuclear atypism. The nodular mass evaluated as a capillary hemangioma. PMID:25370407

K?vanç, Sertaç Argun; Olcaysu, Osman Okan; Gelincik, Ibrahim

2014-01-01

175

Minimal invasive method to treat hemangiomas of the oral cavity with a CO2 laser  

NASA Astrophysics Data System (ADS)

During the last six years we have developed a new CO2 laser technique for the treatment of symptomatic oral cavity hemangioma. Our new technique, named 'laser encircling technique', has especially succeeded during hemangioma buccal maxillary surgeries. The treatment consisted in the application of a line of points of CO2 laser circling the lesion. Depending on the position and size of the lesion, we used from 0.4 to 4.0 Joules/mm2 laser energy density per pulse, causing reduction in the size of the lesion throughout the sclerosis of nutritional vessels which led to reduction in size, volume and color of the hemangiomas with no significant bleeding or inflammatory reaction. In this work forty male and female patients, twelve to fifty years old, presenting medium to small size hemangiomas situated in different sites of the oral cavity such as the tongue, mouth vestibule, pharynx, tonsil area and lips were treated by the procedure described above. The number of laser applications was defined by the peculiarities of each case, varying form 3 to 6 sessions at 4 week intervals, always under local or topic anesthesia. The patients complained about minimal posit operative discomfort and had good cicatrix evolution. The good results achieved by this technique lead to the conclusion that CO2 laser for these types of hemangioma is an efficient and very secure method of treatment. An important aspect of our technique is the fact that using relatively low laser power we do not perform real surgery but a less aggressive alternative of treatment.

Nicola, Ester M. D.; Nicola, Jorge H.; Gusmao, Reinaldo J.; Coutinho, Adriana A.; Cassitas, Nilceu P.

1997-05-01

176

Theory of Giant Planets  

NASA Astrophysics Data System (ADS)

Giant planet research has moved from the study of a handful of solar system objects to that of a class of bodies with dozens of known members. Since the original 1995 discovery of the first extrasolar giant planets (EGPs), the total number of known examples has increased to ~80 (circa November 2001). Current theoretical studies of giant planets emphasize predicted observable properties, such as luminosity, effective temperature, radius, external gravity field, atmospheric composition, and emergent spectra as a function of mass and age. This review focuses on the general theory of hydrogen-rich giant planets; smaller giant planets with the mass and composition of Uranus and Neptune are not covered. We discuss the status of the theory of the nonideal thermodynamics of hydrogen and hydrogen-helium mixtures under the conditions found in giant-planet interiors, and the experimental constraints on it. We provide an overview of observations of extrasolar giant planets and our own giant planets by which the theory can be validated.

Hubbard, W. B.; Burrows, A.; Lunine, J. I.

177

Autoimmune hepatitis  

MedlinePLUS

Autoimmune hepatitis is inflammation of the liver that occurs when immune cells mistake the liver's normal cells for ... lupus erythematosus Thyroiditis Type 1 diabetes Ulcerative colitis ... sometimes occurs in relatives of people with autoimmune ...

178

Autoimmune Hepatitis  

Microsoft Academic Search

Autoimmune hepatitis (AIH) is an inflammatory liver disease with a strong female preponderance, characterized by elevated\\u000a levels of transaminases and immunoglobulin G (IgG), seropositivity for organ and non-organ-specific autoantibodies, and a\\u000a histological picture of interface hepatitis. The major pathogenic mechanism is believed to be immune reaction against host\\u000a liver antigens. AIH responds well to immuno-suppressive treatment. The diagnosis should be

Diego Vergani; Giorgina Mieli-Vergani

179

Hepatitis virus panel  

MedlinePLUS

The hepatitis virus panel is a series of blood tests used to detect current or past infection by hepatitis A , hepatitis ... samples for more than one kind of hepatitis virus at the same time. Antibody and antigen tests ...

180

Unstable giant gravitons  

SciTech Connect

We find giant graviton solutions in Frolov's three parameter generalization of the Lunin-Maldacena background. The background we study has {gamma}-tilde{sub 1}=0 and {gamma}-tilde{sub 2}={gamma}-tilde{sub 3}={gamma}-tilde. This class of backgrounds provides a nonsupersymmetric example of the gauge theory/gravity correspondence that can be tested quantitatively, as recently shown by Frolov, Roiban, and Tseytlin. The giant graviton solutions we find have a greater energy than the point gravitons, making them unstable states. Despite this, we find striking quantitative agreement between the gauge theory and gravity descriptions of open strings attached to the giant.

Mello Koch, Robert de [Department of Physics and Centre for Theoretical Physics, University of the Witwatersrand, Wits, 2050 (South Africa); Stellenbosch Institute for Advanced Studies, Stellenbosch (South Africa); Ives, Norman; Smolic, Jelena; Smolic, Milena [Department of Physics and Centre for Theoretical Physics, University of the Witwatersrand, Wits, 2050 (South Africa)

2006-03-15

181

Giant prostatic calculi  

PubMed Central

Prostatic parenchymal calculi are common, usually incidental, findings on morphological examinations. They are typically asymptomatic and may be present in association with normal glands, benign prostatic hyperplasia, and prostate cancer. However giant prostatic calculi are rare. Less than 20 cases have been reported in the literature. We present the case of a 35-year-old man with two giant prostatic calculi that replaced the entire gland. He underwent an open cystolithotomy, two giant stones were removed from the prostate, and we used a lithotripsy in situ for extraction of stone fragments. PMID:23565316

Najoui, Mohammed; Qarro, Abdelmounaim; Ammani, Abdelghani; Alami, Mohammed

2013-01-01

182

Integrated imaging of hepatic tumors in childhood. Part II. Benign lesions (congenital, reparative, and inflammatory)  

SciTech Connect

The authors have encountered benign liver masses as frequently as malignant lesions in children with hepatomegaly. Lesions studied included abscesses, cavernous hemangioma/hemangioendothelioma, adenoma of glycogen storage disease, choledochal cysts, focal nodular hyperplasia, cystic hepatoblastoma, and hamartoma. An intergrated imaging protocol involving ultrasound, computed tomography, and scintigraphy proved to be more helpful than any one modality in establishing the benign or malignant nature of a hepatic neoplasm and the type of tumor, which is of particular importance when surgical exploration and/or biopsy is contraindicated.

Miller, J.H.; Greenspan, B.S.

1985-01-01

183

Primary Intraosseous Cavernous Hemangioma of the Clivus: Case Report and Review of the Literature  

PubMed Central

Primary intraosseous hemangiomas are benign, vascular malformations that account for approximately 1% of all primary bone neoplasms. These tumors are mostly found in vertebral bodies and are rarely seen in the calvarium, where they represent 0.2% of bony neoplasms. When found in the skull, they tend to present with vague symptoms and do not have the typical radiological findings suggestive of hemangiomas. Because of this, these tumors can be missed in many cases or may be misinterpreted as more ominous lesions like multiple myeloma or osteosarcoma. Involvement of the skull base is exceedingly rare, and presentation with cranial nerve unilateral polyneuropathies has not been reported. We report a patient case with review of recent pertinent literature. PMID:23943715

Gologorsky, Yakov; Shrivastava, Raj K.; Panov, Fedor; Mascitelli, Justin; Signore, Anthony Del; Govindaraj, Satish; Smethurst, Mark; Bronster, David J.

2013-01-01

184

Near-infrared laser treatment of complicated hemangiomas in children: ten-year clinical experience  

NASA Astrophysics Data System (ADS)

Results of application of low invasive laser technology (developed by authors: Proc. SPIE 5863, 107-115 (2005), Russian Federation patent No.2290228 of.27.12.06) to treatment of hemangiomas in children are presented and analyzed in this work. From 2001 the technology was applied to about 1500 children with more than 2000 hemangiomas. Majority of them were complicated ones: belong to cavernous or combined types or (and) were localized on problem places: on face near eyes, nose, and lips, on auricles, on perineum near anus and genitals, in respiratory and gastrointestinal tracts. Diode laser with wavelength 920, 970, and 1060 nm at distant and interstitial irradiation were applied. In case of need there applied endoscopes. Excellent and good results have been achieved in 94% cases; there was a significant improvement in the rest cases.

Abushkin, Ivan A.; Privalov, Valeriy A.; Lappa, Alexander V.

2011-03-01

185

[POEMS syndrome with an isolated lytic lesion and glomeruloid hemangiomas: report of one case].  

PubMed

POEMS syndrome (polyneuropathy, organomegaly, endocrine abnormality, M-protein, plasma cell dyscrasia, and skin lesions) is a rare atypical plasma cell dyscrasia with characteristic para neoplastic manifestations. Glomeruloid hemangioma is a typical skin change pathogenetically related with elevated levels of Vascular Endothelial Growth Factor (VEGF). We report a 69 year-old woman that presented cachexia associated with diabetes, hypothyroidism and severe sensitive motor polyneuropathy. Her skin changes included hyper pigmentation, acrocyanosis and glomeruloid hemangioma. The subsequent study revealed a monoclonal gammopathy lambda type; a unique lytic vertebral lesion and a clonal plasma cell proliferation. Treatment with prednisone 0.5 mg/kg and melphalan 0,25 mg/kg in cycles of 4 days every 4 weeks was started, but the patient was lost from follow up. PMID:19701559

Chandía, Mauricio; Salomone, Claudia; Bertín, Pablo; González, Sergio

2009-05-01

186

Hemangioma of the prostatic urethra: hematospermia and massive postejaculation hematuria with clot retention.  

PubMed

The case of a 53-year-old man with hematospermia and massive postejaculation hematuria that caused urinary retention is described. This is the sixth case in the English and Japanese language literature. Cystourethroscopic examination revealed that a solitary raised tumor was present just distal to the vermontanum, and that bleeding was from its apex. Histologic examination of an excisional biopsy sample showed features compatible with hemangioma. PMID:9354960

Furuya, S; Ogura, H; Tanaka, Y; Tsukamoto, T; Isomura, H

1997-09-01

187

Alveolar soft part sarcoma following radiotherapy for a spinal hemangioma. A case report  

SciTech Connect

A case of alveolar soft part sarcoma arising some 20 years later in a site previously irradiated as a treatment for a spinal cord hemangioma is described. This is the first known case of radiation-associated alveolar soft part sarcoma, and it fulfills the criteria for a tumor to be radiation-induced. The coincidental finding of ''viral-like'' particles within some of the tumor cells was noted.

Wang, S.; Mirra, J.; Bhuta, S.

1984-06-15

188

Management of periorbital hemangioma by intralesional glucocorticoids and systemic propranolol: a single-center retrospective study  

PubMed Central

Periorbital hemangioma may lead to the vision impairment so effective treatment should be adopted in time. In this study, we made a retrospective analysis of intralesional glucocorticoids and systemic propranolol in the management of periorbital hemangioma. From Jan. 2006 to Dec. 2013, twenty-five children with periorbital hemangioma were enrolled into this study. Among them, sixteen children accepted intralesional injection of compound betamethasone preparation. Eight children accepted systemic propranolol. One child accepted both of the two treatments. The follow-up period ranged from 6 months to 60 months. The results showed that in the patients with intralesional compound betamethasone preparation, 13/16 patients’ tumors involuted completely. 3/16 patients’ tumors didn’t involute completely at the end of follow-up. In the patients with systemic propranolol, 8/8 patients’ tumors involuted almost completely. One patient didn’t respond to intralesional glucocorticoids, and so switched to systemic propranolol, which lead to the involution of tumor finally. The adverse effects in the patients with intralesional glucocorticoids included local soft tissue atrophy, local ulcer, and Cushing-like manifestations, which occurred in three patients respectively. In the patients with systemic propranolol, mild diarrhoea occurred in one child. According to our observation, both of intralesional glucocorticoids and systemic propranolol achieved good results in the management of periorbital hemangioma. Systemic propranolol showed superiority in efficacy and safety. We recommend systemic propranolol as the first-line therapy. However, for the children who can’t tolerate systemic propranolol, intralesional glucocorticoids still is a feasible choice. PMID:24955168

Yuan, Si-Ming; Cui, Lei; Guo, Yao; Xue, Chun-Yan; Hong, Zhi-Jian; Jiang, Hui-Qing

2014-01-01

189

The Giant Cell.  

ERIC Educational Resources Information Center

Provides directions for the construction of giant plastic cells, including details for building and installing the organelles. Also contains instructions for preparing the ribosomes, nucleolus, nucleus, and mitochondria. (DDR)

Stockdale, Dennis

1998-01-01

190

Giant distal humeral geode.  

PubMed

We describe the imaging features of a giant geode of the distal humerus in a patient with rheumatoid arthritis, which presented initially as a pathological fracture. The value of magnetic resonance imaging in establishing this diagnosis is emphasized. PMID:10794554

Maher, M M; Kennedy, J; Hynes, D; Murray, J G; O'Connell, D

2000-03-01

191

Seismology of Giant Planets  

E-print Network

Seismology applied to giant planets could drastically change our understanding of their deep interiors, as it has happened with the Earth, the Sun, and many main-sequence and evolved stars. The study of giant planets' composition is important for understanding both the mechanisms enabling their formation and the origins of planetary systems, in particular our own. Unfortunately, its determination is complicated by the fact that their interior is thought not to be homogeneous, so that spectroscopic determinations of atmospheric abundances are probably not representative of the planet as a whole. Instead, the determination of their composition and structure must rely on indirect measurements and interior models. Giant planets are mostly fluid and convective, which makes their seismology much closer to that of solar-like stars than that of terrestrial planets. Hence, helioseismology techniques naturally transfer to giant planets. In addition, two alternative methods can be used: photometry of the solar light ref...

Gaulme, Patrick; Schmider, Francois-Xavier; Guillot, Tristan

2014-01-01

192

Propranolol enhanced adipogenesis instead of induction of apoptosis of hemangiomas stem cells  

PubMed Central

Propranolol has been widely used in treating infantile hemangiomas (IHs). But recurrence of IHs was found in some cases on cessation of propranolol treatment. The other is that Chinese individuals reacted to propranolol differently from American Whites. Whether the difference of sensitivity is due to the ? adrenoceptor (?-AR) expression pattern of hemangioma initiating cells remains unclear. In the present study, we isolated hemangioma-derived stem cells (hemSCs) from proliferative IHs and analyzed the biological characteristics and ?-AR expression pattern of hemSCs by immunostaining, Western blotting and multilineage differentiation assay as well. We also tested the effects of propranolol on hemSCs by evaluating VEGF expression, proliferation and apoptosis related parameters. Our results indicated that CD133+ hemSCs located pre-vascular in proiferative IH tissues. Both ?1 and ?2-AR were expressed, while ?2-AR was dominant on hemSCs. Propranolol at 100-150 ?M inhibited proliferation of hemSCs, not did 50 ?M. Propranolol down-regulated VEGF expression of hemSCs, instead of inducing apoptosis. The adipogenic potential was enhanced by propranolol. Therefore, our current results suggested propranolol could not induce apoptosis of hemSCs, but played a curative role though suppressing VEGF synthesis and enhancement of adipogenesis of hemSCs. Our results might partially provide the insight of mechanism of relapse in some cases on cessation of propranolol treatment. PMID:25120757

Ma, Xiaorong; Zhao, Tinghui; Ouyang, Tianxiang; Xin, Shujia; Ma, Yueting; Chang, Mengling

2014-01-01

193

Central Retinal and Posterior Ciliary Artery Occlusion After Intralesional Injection of Sclerosant to Glabellar Subcutaneous Hemangioma  

SciTech Connect

The aim of this study is to describe vision loss caused by central retinal artery and posterior ciliary artery occlusion as a consequence of sclerotherapy with a polidocanol injection to a glabellar hemangioma. An 18-year-old man underwent direct injection with a 23-gauge needle of 1 mL of a polidocanol-carbon dioxide emulsion into the glabellar subcutaneous hemangioma under ultrasound visualization of the needle tip by radiologists. He developed lid swelling the next day, and 3 days later at referral, the visual acuity in the left eye was no light perception. Funduscopy revealed central retinal artery occlusion and fluorescein angiography disclosed no perfusion at all in the left fundus, indicating concurrent posterior ciliary artery occlusion. The patient also showed mydriasis, blepharoptosis, and total external ophthalmoplegia on the left side. Magnetic resonance imaging demonstrated the swollen medial rectus muscle. In a month, blepharoptosis and ophthalmoplegia resolved but the visual acuity remained no light perception. Sclerosing therapy for facial hemangioma may develop a severe complication such as permanent visual loss.

Matsuo, Toshihiko, E-mail: matsuot@cc.okayama-u.ac.j [Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Department of Ophthalmology (Japan); Fujiwara, Hiroyasu; Gobara, Hideo; Mimura, Hidefumi; Kanazawa, Susumu [Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Department of Radiology (Japan)

2009-03-15

194

Ultrasound-guided interstitial Nd:YAG laser therapy of cavernous hemangiomas  

NASA Astrophysics Data System (ADS)

Preoperative embolization and excision used to be standard therapy amongst a wide range of other more or less successful methods for the treatment of voluminous hemangiomas. Nowadays a combination of argon, tunable dye, copper vapor and Nd:YAG laser therapy achieves better cosmetic and functional results. Due to its limited penetration depth percutaneous laser therapy can only be utilized for superficial vascular malformations. Interstitial laser therapy, as performed with the Nd:YAG laser, allows treatment of voluminous hemangiomas in their full extent. The localization of these vascular lesions is evaluated by high resolution ultrasound with a new anular array scanner which ensures the precise intraoperative placement of the laser light fiber in the target tissue. Modified new light applicators improve the interstitial thermotherapy of hemangiomas. The tip design of the scattering-dome fiber allows diffuse circumferential irradiation with larger defined coagulation volume and minimized carbonization. Continuous intraoperative sonographic monitoring lowers the risk of damaging adjacent intact anatomical structures, helps to reach all tumor areas an to estimate the effect of the applied laser light caused by changes of sonomorphology. The postoperative outcome is evaluated by B-mode sonography and the new technique of ultrasound color angiography.

Hoffmann, Peter; Offergeld, Christian F.; Huettenbrink, Karl-Bernd; Hackert, I.; Scholz, A.

1995-05-01

195

Hepatitis C.  

PubMed

The hepatitis C virus (HCV) genome was isolated during the late 1980s using molecular cloning techniques. It is recognized as the cause of most cases of percutaneously transmitted non-A, non-B hepatitis. Prevalence of antibodies to HCV(anti-HCV) in the general Australian population is 0.3%. However, among regular intravenous drug users the prevalence exceeds 90%. The predominant risk factors for HCV are intravenous drug use, tattoos, exposure to blood products, occupational risk and ethnicity. In contrast to hepatitis B, sexual spread and vertical transmission of HCV from mother to neonate are relatively uncommon. The risk of acquiring HCV from a single HCV-contaminated needlestick accident is about 5%. Most cases of acute HCV infection are asymptomatic, but 50 to 80% progress to chronic disease. The percentage of those with chronic HCV progressing to cirrhosis is not accurately known, but is probably 20%. Treatment strategies for HCV, utilizing recombinant interferons, are proving useful in patients with mild to moderate liver disease, but fare less well in patients with cirrhosis. Currently, there is no vaccine for hepatitis C, so pre-exposure prophylaxis is not possible. Equally, no post-exposure intervention, for example with gamma globulin, has been shown to be beneficial, though there may be a role for early interferon therapy. PMID:9133192

Liddle, C

1996-04-01

196

Juvenile hemangioma: A case report with an emphasis on its clinical phases (evolution and involution), and immunohistochemically distinctive physiologic differences  

PubMed Central

Hemangiomas occupy a grey zone between hamartomatous malformations and true neoplasms. They are frequently designated and regarded as neoplasms because of their usually localized nature and mass effect. Although clearly benign, they can become very large and unsightly, and can even be fatal if they affect vital structures. They almost never become malignant, although a few documented examples of this complication are on record. A high percentage occur in children, manifesting within the first month of life. One half of these cases are in the head and neck area. Hemangiomas have been classified according to their clinical appearance and the caliber of vessel involved, namely, capillary, cavernous and venous. Capillary hemangiomas are made up of small vessels of capillary caliber. One such capillary hemangioma, the juvenile hemangioma (JH), is usually present at birth or appears during the first month and enlarges rapidly during the first few months of life (infancy), only to stop growing when the child is approximately 6 years old. We present one such JH, seen in a 3 year old male child, which appeared when the child was 2 months old. Routine histopathological (H and E) and immunohistochemical analysis (CD 34, CD 31) was done on biopsy received. PMID:22144837

Bhagalia, Sanjay R; Pardhe, Nilesh; Gupta, Manu; Jain, Manish

2011-01-01

197

Nonselective ?-blocker propranolol for orbital and periorbital hemangiomas in infants: a new first-line of treatment?  

PubMed Central

Purpose To determine the effectiveness and possible side effects of using propranolol for the treatment of orbital and periorbital infantile hemangiomas. Methods Infants with periorbital or orbital hemangiomas who had not received either local or systemic corticosteroids were recruited. The changes in tumor size, color, and texture, and any side effects of the drug were recorded. Results Fifteen infants with a mean age of 8.13 ± 4.7 months were treated according to the set protocol. A change in the color and texture of the hemangioma occurred in the first week following treatment. Mean duration of treatment was 7.67 ± 3.96 months. The size of hemangiomas decreased from a mean of 2.4 ± 0.9 cm to a mean of 1.6 ± 1.0 cm 3 months after treatment (P = 0.001). One patient had to stop the drug because of peripheral vascular ischemia. Another case had the dose reduced to control a mild hyperglycemia. Serious side effects were not observed. A single case of tumor regrowth (8.3%) was recorded. Conclusion Treatment of 1–2 mg/kg/day propranolol proved to be effective and associated with minimal side effects. It is likely to replace steroids as the first-line of treatment of hemangiomas in infants. PMID:22140311

El-Essawy, Rania; Galal, Rascha; Abdelbaki, Sameh

2011-01-01

198

Ptotic Gall Bladder with Hepatic Masses: A Case Report  

PubMed Central

Gall bladder (GB) may be found in a variety of abnormal positions. Most of them are due to arrested development of embryonic growth at different stages. A 63-year-old female patient was admitted to our radiology unit for magnetic resonance imaging (MRI) of the liver for the lesions identified in abdominal ultrasonography (US) and computed tomography (CT). MRI showed that there was a lobulated heterogenous mass in the left lobe of the liver and a smaller one in the right lobe of the liver with the same appearance. The inferior pole of the liver was located in the pelvic space, and the GB, which contained sludges and stones, was lying down to the upper pelvic space. Hepatic masses were considered to be hemangiomas, and GB was diagnosed as ptotic GB with luminal sludge and stones. In this case, especially, MR imaging helped the surgeon to plan a proper approach to the GB in abnormal localization. PMID:23476872

Aydin, Hasan; Aydin, Z. Banu; Hekimoglu, Baki; Gormeli, Ayse

2013-01-01

199

Giant congenital melanocytic nevus.  

PubMed

Giant congenital melanocytic nevus is usually defined as a melanocytic lesion present at birth that will reach a diameter ? 20 cm in adulthood. Its incidence is estimated in <1:20,000 newborns. Despite its rarity, this lesion is important because it may associate with severe complications such as malignant melanoma, affect the central nervous system (neurocutaneous melanosis), and have major psychosocial impact on the patient and his family due to its unsightly appearance. Giant congenital melanocytic nevus generally presents as a brown lesion, with flat or mammilated surface, well-demarcated borders and hypertrichosis. Congenital melanocytic nevus is primarily a clinical diagnosis. However, congenital nevi are histologically distinguished from acquired nevi mainly by their larger size, the spread of the nevus cells to the deep layers of the skin and by their more varied architecture and morphology. Although giant congenital melanocytic nevus is recognized as a risk factor for the development of melanoma, the precise magnitude of this risk is still controversial. The estimated lifetime risk of developing melanoma varies from 5 to 10%. On account of these uncertainties and the size of the lesions, the management of giant congenital melanocytic nevus needs individualization. Treatment may include surgical and non-surgical procedures, psychological intervention and/or clinical follow-up, with special attention to changes in color, texture or on the surface of the lesion. The only absolute indication for surgery in giant congenital melanocytic nevus is the development of a malignant neoplasm on the lesion. PMID:24474093

Viana, Ana Carolina Leite; Gontijo, Bernardo; Bittencourt, Flávia Vasques

2013-01-01

200

[Major hepatic resections for angioma].  

PubMed

6 cases of solitary angioma of the liver, treated with major hepatic resections, are presented (2 rt hemihepatectomies - 2 lt hemihepatectomies - 1 lt lateral sect. and 1 segmentectomy of the VIth). Their anatomopathological definition (solitary angioma, multiple angiomas, hemangiomatosis) is discussed in relation to the various therapeutic possibilities. From the diagnostic standpoint, an outstanding part is played by angiography. In addition to demonstrating the presence of hepatic mass, C.A.T. can, according to their experience, also allow diagnosis of quality on the basis of demonstration of vascular lacunae. It is considered that the treatment of choice of for solitary angiomas is surgery, which must be performed by skilled surgeons and consist in hepatic resections conduced by typical route. This is especially true for the giant forms, owing to their particular tendency to growth and spontaneous rupture. For small angiomas it is considered better in principle to remove them, generally by small cuneiform resections, unless they are situated in sites difficult to attack surgically and with high risk. In this case frequent check-up is necessary since, although they are sometimes found to be stationary and even in exceptional cases regressive, personal experience (2 cases) has demonstrated a tendency to expansion. PMID:7249194

Nicoli, N; Serio, G; Pederzoli, P; Mainente, M; Tenchini, P; Marchiori, L; Dagradi, A

1980-12-01

201

Giant resonance decay  

SciTech Connect

Decay studies of giant multipole resonances are discussed, emphasizing the role of Coulomb excitation with intermediate energy heavy ions, which can provide very large cross sections for both isoscalar and isovector resonances. We discuss measurement of the photon decay of one and two phonon giant resonances, reporting results where available. It is pointed out throughout the presentation that the use of E1 photons as a tag'' provides a means to observe weakly excited resonances that cannot be observed in the singles spectra. 30 refs., 16 figs., 1 tab.

Beene, J.R.; Bertrand, F.E.

1990-01-01

202

Drug-induced hepatitis  

MedlinePLUS

Toxic hepatitis ... to get liver damage. Some drugs can cause hepatitis with small doses, even if the liver breakdown ... liver. Many different drugs can cause drug-induced hepatitis. Painkillers and fever reducers that contain acetaminophen are ...

203

Autoimmune hepatitis  

Microsoft Academic Search

Autoimmune hepatitis (AIH) is a rare disease, characterized by female predominance, hypergammaglobulinemia, autoantibodies, association with HLA DR3 and HLA DR4 and a good response to immunosuppression. Different subtypes of AIH may be distinguished, based on differences in the autoantibody patterns. AIH type 1 is characterized by anti-nuclear (ANA) and\\/or anti-smooth muscular (SMA) autoantibodies. AIH type 2 is characterized by liver\\/kidney

Petra Obermayer-Straub; Christian P. Strassburg; Michael P. Manns

2000-01-01

204

Hepatic Encephalopathy  

Microsoft Academic Search

\\u000a Hepatic encephalopathy (HE) reflects a spectrum of neuropsychiatric abnormalities seen in patients with liver dysfunction\\u000a after exclusion of other known brain disease [1]. HE is primarily divided into two components: overt HE (OHE) and minimal\\u000a HE (MHE). OHE is the specific type of HE that can be diagnosed clinically through a constellation of signs and symptoms while\\u000a MHE cannot be

Jasmohan S. Bajaj; Kevin D. Mullen

205

Hepatitis B  

Microsoft Academic Search

\\u000a The discovery of hepatitis B virus (HBV) did not arise from a goal-directed search for this pathogen but from studies in basic\\u000a science that were initially set on a different path. Much of the early research that resulted in the discovery of the virus,\\u000a the invention of diagnostics, and the development of a vaccine was conducted at the Division of

Baruch S. Blumberg

206

Elevated T-box 2 in infantile hemangioma stem cells maintains an adipogenic differentiation-competent state  

PubMed Central

Infantile hemangioma is a benign vascular tumor that affects 4 to 10% of neonates. A unique feature of hemangiomas is the natural lifecycle, whereby the tumor rapidly grows and then spontaneously regresses to a fibrofatty residuum. We have shown that hemangiomas are derived from multipotential stem cells (hemSCs), which differentiate into endothelial cells during the early proliferating phase and into adipocytes during the later involutive phase. T-box 2 (TBX2) is a transcription factor involved in controlling cell-fate decisions, and is highly expressed during the proliferating phase of hemangioma development. We hypothesize that TBX2 expression would be high in hemSCs derived from human hemangiomas and inhibiting TBX2 would result in changes in hemSC differentiation potential. To test our hypothesis, we analyzed hemSCs for TBX2 mRNA and protein expression. We then used RNA interference and TBX2 overexpression to determine the effect of altering TBX2 levels on hemSC growth and differentiation. Our studies show that TBX2 is highly expressed in hemSCs compared with a panel of normal stem/progenitor cells and mature vascular cells. TBX2 knockdown completely abolished adipogenic differentiation of hemSCs without significantly altering growth. Furthermore, overexpression of TBX2 led to enhanced adipogenic differentiation ability possibly through induction of C/EBP?. From these findings, we believe that TBX2 is active in hemSCs and that TBX2 maintains an adipogenic differentiation-competent state of hemSCs. These findings may be important in the development of better treatment options for hemangiomas to accelerate involution. PMID:24516689

Todorovich, Sydney M.; Khan, Zia A.

2013-01-01

207

Elevated T-box 2 in infantile hemangioma stem cells maintains an adipogenic differentiation-competent state.  

PubMed

Infantile hemangioma is a benign vascular tumor that affects 4 to 10% of neonates. A unique feature of hemangiomas is the natural lifecycle, whereby the tumor rapidly grows and then spontaneously regresses to a fibrofatty residuum. We have shown that hemangiomas are derived from mutlipotential stem cells (hemSCs), which differentiate into endothelial cells during the early proliferating phase and into adipocytes during the later involutive phase. T-box 2 (TBX2) is a transcription factor involved in controlling cell-fate decisions, and is highly expressed during the proliferating phase of hemangioma development. We hypothesize that TBX2 expression would be high in hemSCs derived from human hemangiomas and inhibiting TBX2 would result in changes in hemSC differentiation potential. To test our hypothesis, we analyzed hemSCs for TBX2 mRNA and protein expression. We then used RNA interference and TBX2 overexpression to determine the effect of altering TBX2 levels on hemSC growth and differentiation. Our studies show that TBX2 is highly expressed in hemSCs compared with a panel of normal stem/progenitor cells and mature vascular cells. TBX2 knockdown completely abolished adipogenic differentiation of hemSCs without significantly altering growth. Furthermore, overexpression of TBX2 led to enhanced adipogenic differentiation ability possibly through induction of C/EBP?. From these findings, we believe that TBX2 is active in hemSCs and that TBX2 maintains adipogenic differentiation-competent state of hemSCs. These findings may be important in the development of better treatment options for hemangiomas to accelerate involution. PMID:24516689

Todorovich, Sydney M; Khan, Zia A

2013-06-01

208

Diabetes and Hepatitis B Vaccination  

MedlinePLUS

Diabetes and Hepatitis B Vaccination Information for Diabetes Educators What is hepatitis B? Hepatitis B is a contagious liver disease that ... as liver failure or liver cancer. How is hepatitis B spread? The hepatitis B virus is usually ...

209

Emergent medical and surgical management of mediastinal infantile hemangioma with symptomatic spinal cord compression: case report and literature review  

Microsoft Academic Search

Purpose  We report an extremely rare case of a patient with a large, cervical, and upper thoracic cutaneous hemangioma associated with\\u000a a separate, underlying mediastinal hemangioma extending to the epidural space causing significant spinal cord compression.\\u000a \\u000a \\u000a \\u000a \\u000a Case report  A 6-week-old female presented with decreased movement of her right arm and bilateral lower extremity hyperreflexia. Her arm\\u000a weakness progressed to paralysis over the

Daniel H. Fulkerson; Nnenna G. Agim; George Al-Shamy; Denise W. Metry; Shayan A. Izaddoost; Andrew Jea

2010-01-01

210

Initiation and use of propranolol for infantile hemangioma: report of a consensus conference.  

PubMed

Infantile hemangiomas (IHs) are common neoplasms composed of proliferating endothelial-like cells. Despite the relative frequency of IH and the potential severity of complications, there are currently no uniform guidelines for treatment. Although propranolol has rapidly been adopted, there is significant uncertainty and divergence of opinion regarding safety monitoring, dose escalation, and its use in PHACE syndrome (PHACE = posterior fossa, hemangioma, arterial lesions, cardiac abnormalities, eye abnormalities; a cutaneous neurovascular syndrome characterized by large, segmental hemangiomas of the head and neck along with congenital anomalies of the brain, heart, eyes and/or chest wall). A consensus conference was held on December 9, 2011. The multidisciplinary team reviewed existing data on the pharmacologic properties of propranolol and all published reports pertaining to the use of propranolol in pediatric patients. Workgroups were assigned specific topics to propose protocols on the following subjects: contraindications, special populations, pretreatment evaluation, dose escalation, and monitoring. Consensus protocols were recorded during the meeting and refined after the meeting. When appropriate, protocol clarifications and revision were made and agreed upon by the group via teleconference. Because of the absence of high-quality clinical research data, evidence-based recommendations are not possible at present. However, the team agreed on a number of recommendations that arose from a review of existing evidence, including when to treat complicated IH; contraindications and pretreatment evaluation protocols; propranolol use in PHACE syndrome; formulation, target dose, and frequency of propranolol; initiation of propranolol in infants; cardiovascular monitoring; ongoing monitoring; and prevention of hypoglycemia. Where there was considerable controversy, the more conservative approach was selected. We acknowledge that the recommendations are conservative in nature and anticipate that they will be revised as more data are made available. PMID:23266923

Drolet, Beth A; Frommelt, Peter C; Chamlin, Sarah L; Haggstrom, Anita; Bauman, Nancy M; Chiu, Yvonne E; Chun, Robert H; Garzon, Maria C; Holland, Kristen E; Liberman, Leonardo; MacLellan-Tobert, Susan; Mancini, Anthony J; Metry, Denise; Puttgen, Katherine B; Seefeldt, Marcia; Sidbury, Robert; Ward, Kendra M; Blei, Francine; Baselga, Eulalia; Cassidy, Laura; Darrow, David H; Joachim, Shawna; Kwon, Eun-Kyung M; Martin, Kari; Perkins, Jonathan; Siegel, Dawn H; Boucek, Robert J; Frieden, Ilona J

2013-01-01

211

Anastomosing hemangioma of the liver and gastrointestinal tract: an unusual variant histologically mimicking angiosarcoma.  

PubMed

Anastomosing hemangioma, a benign vascular neoplasm histologically simulating angiosarcoma, is newly recognized and has been described primarily in the genitourinary tract. We have encountered this lesion in the liver and gastrointestinal tract, where it can be diagnostically challenging, especially in core biopsy. Herein, we described 6 cases of anastomosing hemangioma of the liver and gastrointestinal tract. They occurred in 4 women and 2 men, ranging in age from 48 to 71 years. The tumors ranged from 0.2 to 6 cm (median, 3.1 cm) and were grossly well demarcated with a gray-brown spongy appearance. Microscopically, they had a loosely lobulated architecture. At higher magnification, lesions consisted of anastomosing sinusoidal capillary-sized vessels with scattered hobnail endothelial cells. Mild cytologic atypia occurred in all cases. Mitoses were absent. Vascular thrombi were seen in 4 cases (66.7%) without necrosis. One tumor (16.7%) featured prominent extramedullary hematopoiesis and 1 (16.7%) hyaline globules. Immunohistochemistry results were available for 3 cases, and the lesions stained with CD34 and/or CD31. Five cases had clinical follow-up information; there were no recurrences or metastases (range, 8 to 96 mo; mean, 41 mo), and 1 patient received no follow-up after a benign diagnosis on her colon polyp. In summary, anastomosing hemangioma of the liver and gastrointestinal tract is a rare distinctive vascular neoplasm displaying overlapping features with well-differentiated angiosarcoma. Despite small numbers and limited follow-up information in our series, evidence to date supports that the lesion is benign. Awareness of this entity is essential to avoid overdiagnosis and unnecessary aggressive treatment. PMID:23887160

Lin, Jingmei; Bigge, Jeremy; Ulbright, Thomas M; Montgomery, Elizabeth

2013-11-01

212

The treatment of hemangiomas: with special reference to the role of steroid therapy.  

PubMed Central

Hemangiomas are the most common of all human birth defects. The author has reviewed a 25-year personal experience with treatment of over 1000 patients with a variety of common and rare developmental vascular anomalies. Attention is given to a more useful clinical classification of these disorders. The classification is intended to be helpful in estimating prognosis of the lesions and as a guide to the choice of therapy. Many treatment modalities are evaluated--some successful and some quite disappointing. Surgical excision, irradiation, CO2 freezing, sclerosing agents, cauterization, steroid therapy and watchful waiting are among the treatment methods evaluated. High dose--short course Prednisone therapy has proved to be a major new addition to the treatment of massive juvenile capillary hemangiomas. Numerous misconceptions have appeared in the medical literature. These are noted and a philosophic basis for present day management is suggested for each type angioma. The roles of growth, resolution, histologic picture and sense of deformity are considered in viewing the surgeon's approach to these difficult and challenging problems. Some evidence and speculations are offered as to the etiology, neurogenic influences and physiological dynamics of the various hemangiomas. Images Figs. 1a and b. Fig. 2a. Fig. 2b. Fig. 2c. Fig. 3a. Figs. 3b and 3c. Fig. 3d. Fig. 3e. Figs. 3f and g. Figs. 3h. Fig. 3i. Fig. 3j. Figs. 4a and b. Fig. 5a. Fig. 5b. Fig. 6. Fig. 7a. Fig. 7b. Fig. 7c. Fig. 8a. Fig. 8a. Fig. 8c. PMID:776106

Edgerton, M T

1976-01-01

213

Giant Planets Tristan Guillot  

E-print Network

. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 2.5 Energy balance and atmospheric temperature profiles . . . . . . . . . . . . . . . . 10 2.6 Atmospheric dynamics: winds and weather . . . . . . . . . . . . . . . . . . . . . . 11 2.7 Moons and rings for planetary formation models 34 6 Future prospects 35 2 hal-00439598,version1-8Dec2009 #12;The Giant Planets

Paris-Sud XI, Université de

214

Giant adrenal myelolipoma  

Microsoft Academic Search

Authors present a case of giant adrenal myelolipoma, where the tumor was hormonally inactive but caused abdominal and flank\\u000a pain. The huge tumor, a 20×18×10 cm mass, was surgically removed. The ipsilateral kidney was preserved.

Dénes L. Répássy; Sándor Csata; G. Sterlik; András Iványi

2001-01-01

215

Finite size giant magnon  

SciTech Connect

The quantization of the giant magnon away from the infinite size limit is discussed. We argue that this quantization inevitably leads to string theory on a Z{sub M} orbifold of S{sup 5}. This is shown explicitly and examined in detail in the near plane-wave limit.

Ramadanovic, Bojan; Semenoff, Gordon W. [Department of Physics and Astronomy, University of British Columbia, Vancouver, British Columbia, V6T 1Z1 (Canada)

2009-06-15

216

Three-dimensional stereophotogrammetry: a novel method in volumetric measurement of infantile hemangioma.  

PubMed

Accurate and objective measurement of volume changes in infantile hemangiomas (IHs) is essential in routine clinical practice and clinical studies, particularly in the changing therapeutic landscape after the discovery of propranolol. Several bedside techniques for volume measurement have been described in the literature, but an objective method of measurement of this variable, dynamic vascular tumor is lacking. Three-dimensional (3D) phototechnology with data analysis is an up-and-coming technique in the objective measurement of facial volume changes. In this pilot study, the usability and clinical relevance of two methods of 3D stereophotogrammetry in the volume measurement of IH were explored. PMID:24106998

Hermans, Denise J J; Maal, Thomas J J; Bergé, Stefaan J; van der Vleuten, Catharina J M

2014-01-01

217

Cardiac Hemangioma of RVOT in a Patient with Atypical Chest Pain  

PubMed Central

A 40-year-old man presented with atypical chest pain and fatigue from 15 days ago a suspicious mass in the right ventricle based on a bed side transthoracic echocardiography. Preoperative diagnosis of a cardiac hemangioma comes to mind in a minority of cases. In our case, a cardiac tumor was diagnosed and the vascular nature of the tumor was suggested by vascular blush on the coronary angiography. In addition, right ventriculotomy was the approach of choice in our case because of its inaccessibility and its particular location. PMID:25110477

Vakili, Hossein; Khaheshi, Isa; Foroughi, Mahnoosh; Ghaderi, Hamid; Esmaeeli, Shooka; Jafari, Mostafa

2014-01-01

218

Huge Cavernous Hemangiomas Enveloping the Optic Nerve Successfully Removed by a Vertical Lid Split Orbitotomy  

PubMed Central

A 63-year-old woman presented with a 15-year history of gradually increasing proptosis of right eye. Ocular examination revealed proptosis of 9?mm with decreased visual acuity in her right eye. CT scan showed a well-circumscribed and enhancing orbital mass filling almost the entire right orbit. The tumor occupied the superolateral, superomedial, and inferomedial intraconal space, enveloping the optic nerve. Complete excision of two large intraconal tumors was performed successfully via a vertical lid split orbitotomy. Histopathologic examination confirmed the diagnosis of cavernous hemangioma. There were no intraoperative or postoperative complications. The patient achieved a satisfactory cosmetic outcome 1 year after surgery. PMID:24868473

Yum, Jung-Hoon; Woo, Kyung In

2014-01-01

219

A Council of Giants  

NASA Astrophysics Data System (ADS)

Distances and near-infrared luminosities of the brightest galaxies in the Local Volume have been re-evaluated in order to gain a fully homogeneous collection of data for elucidating the framework of the Local Sheet and its relevance to Local Group evolution. It is demonstrated that the Local Sheet is both geometrically and dynamically distinct from the Local Supercluster and that the evolution of the Sheet and Local Group were probably interconnected. The Sheet is inclined by 8° with respect to the Local Supercluster, and the dispersion of giant members about the mid-plane is only 230 kpc. A `Council of Giants' with a radius of 3.75 Mpc encompasses the Local Group, demarcating a clear upper limit to the realm of influence of the Local Group. The only two giant elliptical galaxies in the Sheet sit on opposite sides of the Council, raising the possibility that they have somehow shepherded the evolution of the Local Group. The position vector of the Andromeda galaxy with respect to the Milky Way deviates only 11° from the Sheet plane and only 11° from the projected axis of the ellipticals. The Local Group appears to be moving away from a ridge in the potential surface of the Council on a path parallel to the elliptical axis. Spin directions of the giants in the Council are distributed over the sky in a pattern which is very different from that of giants beyond, possibly in reaction to the central mass asymmetry that developed into the Local Group. By matching matter densities of Group and Council giants, the edge of the volume of space most likely to have contributed to the development of the Local Group is shown to be very close to where gravitational forces from the Local Group and the Council balance. The boundary specification reveals that the Local Sheet formed out of a density perturbation of very low amplitude (˜10 per cent), but that normal matter was incorporated into galaxies with relatively high efficiency (˜40 per cent). It appears that the development of the giants of the Local Sheet was guided by a pre-existing flattened framework of matter.

McCall, Marshall L.

2014-05-01

220

Primary malignant hepatic glucagonoma: an autopsy case.  

PubMed

A 73-year-old woman was admitted to our department for treatment of diabetes (plasma glucose 289 mg/dl, HbA(1C) 7.1%, and glycated albumin 34.9%). She displayed the signs and symptoms of glucagonoma syndrome, including necrolytic migratory erythema (NME), low aminoacidemia, and a marked increase of the serum glucagon level (4,940 pg/ ml). Thus, we suspected a glucagonoma causing secondary diabetes. However, we could not detect any mass in the pancreas or the gastrointestinal tract, and only found a liver lesion resembling a hemangioma. Her NME improved markedly after intravenous infusion of amino acids, and her plasma glucose was controlled reasonably well by intensive insulin therapy. However, her general condition deteriorated and she died on day 57 after hospitalization. At autopsy, the only tumor detected was the liver mass. This was a large solid tumor (8 x 6 x 5 cm) with a pattern of white and dark brown stripes located in the left lobe, while two white nodules were also found in the right lobe. Based on the histopathological and immunohistochemical findings, the liver lesion was shown to be a malignant glucagonoma with intrahepatic metastases. Since primary malignant hepatic glucagonoma has not been reported before, we present this extremely rare case of primary malignant glucagonoma of the liver. PMID:19367016

Obi, Naoko; Katabami, Takuyuki; Obi, Ryusei; Odanaka, Mieko; Sasano, Kiminobu; Tanaka, Yasushi

2009-01-01

221

A Suspicious Breast Lesion Detected by Dynamic Contrast-Enhanced MRI and Pathologically Confirmed as Capillary Hemangioma: a Case Report and Literature Review  

PubMed Central

Breast capillary hemangioma is a type of benign vascular tumor which is rarely seen. Little is known about its presentation on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Here, we describe a case of suspicious breast lesion detected by DCE-MRI and pathologically confirmed as capillary hemangioma. Our case indicates that a small mass with a superficial location, clear boundary, and homogeneous enhancement on DCE-MRI indicates the possible diagnosis of hemangioma, whereby even the lesion presents a washout type curve. PMID:24265560

Yang, Lian-He; Ma, Shuang; Li, Qing-Chang; Xu, Hong-Tao; Wang, Xin

2013-01-01

222

Proapoptotic effect and the mechanism of action of pingyangmycin on cavernous hemangiomas  

PubMed Central

This study aimed to investigate the proapoptotic effects and the mechanism of action of pingyangmycin (PY) on cavernous hemangioma. The rat spleen was used as a model of cavernous hemangioma. PY was injected into the spleen and the pathological changes were observed at different time-points. Apoptosis was detected using terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay and transmission electron microscopy (TEM). The expression levels of the apoptosis-related protein, caspase-3, were determined using immunohistochemistry and image analysis. Rats injected with normal saline were the control group. Injection of normal saline did not damage rat spleens. On days 2 and 5 following PY injection, the spleens exhibited slight swelling. On days 8 and 14, atrophic changes were observed and the splenic sinus endothelial cells were damaged. At various time-points following PY injection, the apoptotic cells were observed by TEM. The TUNEL assay showed that apoptosis occurred widely among the splenic sinus endothelial cells and other splenic cells. The apoptotic rate and caspase-3 expression levels increased with prolonged PY exposure. PY induced apoptosis of splenic sinus endothelial cells through the caspase-3 activation pathway, and resulted in endothelial cell necrosis and fibroblast hyperplasia. PMID:24396428

HUANG, YIDENG; LI, PING; XIA, SIWEN; ZHUO, YANG; WU, LONGJUN

2014-01-01

223

[Surgery for benign submucosal tumors of the esophagus (leiomyoma and hemangioma)].  

PubMed

Among the submucosal tumors of the esophagus, leiomyoma is the most frequently found. Esophageal leiomyoma usually originates from the muscle layer of the esophageal wall and grows spirally around the esophageal axis. In the surgical treatment of leiomyoma, we enucleate the tumor through video-assisted thoracic surgery. When we enucleate leiomyoma, we must be very careful to aviod perforation of the esophageal mucosa. Esophageal hemangioma is a relatively rare disease. The location of this disease is mainly within the submucosal layer, without invading the muscle layer proper. After confirming the localization within the mucosa or submucosa with endoscopic ultrasonography, esophageal hemangioma can be resected safely using the endoscopic mucosal resection technique. In the treatment of benign esophageal submucosal tumors, "informed consent" is as essential as in esophageal cancer surgery. We have no absolute criteria concerning the indications for surgery for benign esophageal submucosal tumors. We must give reasons why the operation is necessary and indicated to the patients. Surgical treatment of esophageal submucosal tumors should be as minimally invasive as possible. PMID:14574712

Kajiyama, Yoshiaki; Iwanuma, Yoshimi; Tomita, Natsumi; Amano, Takayuki; Uchida, Yosuke; Kudo, Keizo; Ando, Takao; Tsurumaru, Masahiko

2003-09-01

224

Treatment of 28 patients with sclerosing hemangioma (SH) of the lung  

PubMed Central

Background Sclerosing hemangioma (SH) of the lung is a kind of rare pulmonary tumor. Preoperative diagnosis of this tumor is difficult and it is now generally accepted that SH of the lung is benign lesions and surgical excision alone is curative. Herein, we present our experiences of treating 28 patients with SH. Methods The medical records of 28 patients with SH from 1994 to 2010 at the Department of Thoracic Surgery in Beijing Chest Hospital were retrospectively reviewed. Results There were 3 male and 25 female patients with sclerosing hemangioma and 50% of the patients were asymptomatic. Preoperatively, all the patients had undergone CT of chest and 5 patients had undergone PET scan but 4 patients were misdiagnosed as malignancy. There was no operative mortality or tumor recurrence despite that three different operative methods were undertaken. Conclusions SH has a high incidence in middle-aged women. Most of SH is asymptomatic and the symptoms of SH are not related to the tumor size and distribution. The features of chest CT and PET are not specific. Bilateral or multiple lesions should not exclude the possibility of SH. Complete excision of lesion is a curable treatment method and there is no evidence to verify the need of adjuvant therapy. PMID:22515818

2012-01-01

225

Role of MRI in the diagnosis and evaluation of cavernous hemangioma of the arm.  

PubMed

Sinusoidal hemangioma is a rare type of cavernous hemangioma with different clinico-pathological aspects. They are usually localized in the extremities with interest in the subcutaneous layer. The new imaging techniques play an important role in diagnosis, evaluation and follow-up of these types of tumors. We describe the case of a 21-year-old patient, four times operated for a recurrent soft tissue tumor, located intramuscularly in the distal third of the upper limb. Plain X-ray and computer tomography (CT) showed a nonspecific mass with calcification. The MRI (magnetic resonance imaging) exam demonstrated a lobulated heterogeneous signal tumor mass in the biceps brachial muscles, with high signal intensity on T2 weighted images and intermediate signal on T1 weighted images. MRI accurately assessed the extent of the tumor and evaluated the recurrence. MRI imagings combined with contrast-enhanced sequences were used to classify the lesions in low flow vascular disorders. CT angiography with multiplanar reconstructions (MPR), maximum intensity projections (MIP) and volume-rendered reconstructions (VR) was useful in confirming the venous origin of the tumor. PMID:24653757

Ciurea, M E; Bondari, S; Stoica, L E; Gheonea, I A

2014-03-15

226

The Course of Incidental Intraorbital Cavernous Hemangioma in a Patient with Myasthenia Gravis Treated with Cyclosporine: A Case Report  

PubMed Central

A 69-year-old woman presented with generalized myasthenia gravis and a left orbital cavernous hemangioma (OCH), which elevated the optic nerve and displaced the external eye muscles. Cyclosporine treatment induced a gradual size reduction in the OCH, and consequently contributed to improved external ocular symptoms in combination with immunosuppressant effects. PMID:24761144

Konno, Shingo; Hagiwara, Wataru; Sasaki, Miyuki; Fuse, Akihisa; Imamura, Tomomi; Inoue, Masashi; Kitazono, Hisao; Fujioka, Toshiki

2014-01-01

227

Propranolol inhibits angiogenesis via down-regulating the expression of vascular endothelial growth factor in hemangioma derived stem cell  

PubMed Central

Background: Oral propranolol (PRN) has recently been shown to be highly effective for infantile hemangiomas (IHs), and is currently recommended as the first-line treatment of complicated IHs. However, the therapeutic mechanism(s) still remain unclear. Methods: In this study, we tested hemangioma-derived stem cells for expression of vascular endothelial growth factor (VEGF) in vitro and studied the inhibition of VEGF expression. We used PCR, Elisa, Western blotting and immunohistochemistry in vivo and in vitro trial. Results: The study demonstrated that application of PRN at a “normal” concentration equivalent to plasma concentration did not inhibit proliferation or promote apoptosis of hemangioma derived stem cells (HemSCs) isolated from IH patients. PRN suppressed expression of vascular endothelial growth factor (VEGF) and basic Fibroblast Growth Factor (bFGF) in HemSCs in vitro. Morphological, histological and immunohistological improvement were observed in vivo using murine IH model in which HemSCs pre-treated with PRN were implanted into BALB/c-nu mice. In the pre-treated HemSC grafts, mean micro-vessel density (MVD) significantly decreased and protein levels of VEGF markedly decreased, while bFGF was still detectable. Conclusions: The results suggested PRN inhibited angiogenesis via down-regulating the expression of vascular endothelial growth factor in hemangioma derived stem cell. These findings provide critical insight into the potential mechanisms of PRN action on IH. PMID:24427325

Zhang, Ling; Mai, Hua-Ming; Zheng, Jing; Zheng, Jia-Wei; Wang, Yan-An; Qin, Zhong-Ping; Li, Ke-Lei

2014-01-01

228

Congenital tri-cavernous hemangiomas of the right buccal region, right accessory parotid gland, and masseter muscle region.  

PubMed

We report a rare case of congenital tri-cavernous hemangiomas of the right buccal region, right accessory parotid gland, and masseter muscle region in an adult. The patient, a 25-year-old woman, complained of 3 masses in her right midcheek. Ultrasonographic and computed tomographic findings showed an irregular-shaped mass (multiple calcifications) with a well-defined margin in the masseter muscle region, an ellipse-shaped mass (multiple calcifications) with a well-defined margin in the right buccal region, and a comma-shaped mass (no calcifications) with a well-defined margin separate from the parotid gland in the right accessory parotid gland region. These iconographic findings suggested that the masses were all hemangiomas separately originating from the parotid gland, accessory parotid gland, and masseter muscle. The masses were completely removed through a standard parotid incision without postoperative facial palsy, skin deformity, and difficulty in secreting saliva. Findings from histologic examination of the tumor revealed multiple, thin-walled, and dilated blood vessels, confirming the diagnosis of cavernous hemangiomas. Ultrasonographic and computed tomographic findings were extremely useful in diagnosing the mass/masses as hemangioma before surgery, clarifying relationships between the mass and adjacent structures, and determining the surgical approach to the mass/masses. PMID:24621721

Yang, Tao; Gu, Yongchun; Zhang, Li; Hua, Zequan

2014-03-01

229

The giant hand phenomenon.  

PubMed

The "giant hand" is a form of recognized spatial disorientation. An experienced fighter pilot described the events leading up to ejection from his out-of-control aircraft. Investigation of the mishap found no flight control problems and attributed the accident to the giant hand phenomenon. A survey of tactical aircrews indicated that this form of spatial disorientation is not an unusual occurrence. Past training of aircrew to deal with this problem has been inadequate. Earlier reports of this phenomenon recommended attempting to recover the aircraft by grasping the stick using only the thumb and index finger rather than the entire hand. Further investigation to include simulation of this phenomenon in advanced spatial disorientation trainers should contribute to aviation safety. PMID:2923599

Lyons, T J; Simpson, C G

1989-01-01

230

Voyager: Giant Kelp  

NSDL National Science Digital Library

The Birch Aquarium at Scripps Institution of Oceanography offers this Web site as part of the Aquarium's online educational series, Voyager Science. Geared toward younger kids, this site introduces the kelp forest and related concepts with great photos, informative descriptions, and a few interactive activities. Giant Kelp focuses on the kelp plant itself, including the many (and often surprising) commercial uses of kelp products. Simple at-home experiments and online activities are also included.

Criqui, Nan

231

Superstars and giant gravitons  

Microsoft Academic Search

We examine a family of BPS solutions of ten-dimensional type-IIB supergravity. These solutions asymptotically approach AdS5 × S5 and carry internal `angular' momentum on the five-sphere. While a naked singularity appears at the center of the anti-de Sitter space, we show that it has a natural physical interpretation in terms of a collection of giant gravitons. We calculate the distribution

Robert C. Myers

2001-01-01

232

Giant atoms in space  

Microsoft Academic Search

The possible existence of giant hydrogen atoms in interstellar space is examined. Recent radio-line observations have suggested that these atoms may have linear dimensions that are thousands of times greater than those of ordinary atoms, i.e., their dimensions may reach the macroscopic value of 0.1 mm. Electron and ion recombination reactions in the rarefied interstellar medium produce atoms with high

Roman Leonidovich Sorochenko; Aleksandr Efimovich Salomonovich

1987-01-01

233

Red giants seismology  

NASA Astrophysics Data System (ADS)

The space-borne missions CoRoT and Kepler are indiscreet. With their asteroseismic programs, they tell us what is hidden deep inside the stars. Waves excited just below the stellar surface travel throughout the stellar interior and unveil many secrets: how old is the star, how big, how massive, how fast (or slow) its core is dancing. This paper intends to paparazze the red giants according to the seismic pictures we have from their interiors.

Mosser, B.; Samadi, R.; Belkacem, K.

2013-11-01

234

Giant adrenal myelolipoma.  

PubMed

A fifty-two years old male presenting with a history of abdominal pain of six months duration was found on investigation to have a large non-functioning adrenal mass. Adrenal myelolipoma was diagnosed preoperatively and surgical resection was carried out. Only a small number of cases of giant adrenal myelolipoma (>3500 grams) have been reported. A brief review of literature is done. PMID:25003051

Gautam, S C; Raafat, H; Sriganesh, S; Zaffar, I; Olude, I; Komolafe, F; Qazi, F

2013-01-01

235

Giant adrenal myelolipoma  

PubMed Central

A fifty-two years old male presenting with a history of abdominal pain of six months duration was found on investigation to have a large non-functioning adrenal mass. Adrenal myelolipoma was diagnosed preoperatively and surgical resection was carried out. Only a small number of cases of giant adrenal myelolipoma (>3500 grams) have been reported. A brief review of literature is done. PMID:25003051

Gautam, S.C.; Raafat, H.; Sriganesh, S.; Zaffar, I.; Olude, I.; Komolafe, F.; Qazi, F.

2013-01-01

236

Hot giant loop holography  

SciTech Connect

We argue that there is a phase transition in the expectation value of the Polyakov loop operator in the large N limit of the high temperature deconfined phase of N=4 Yang-Mills theory on a spatial S{sup 3}. It occurs for the large completely symmetric representation of the SU(N) symmetry group. We speculate that this transition is reflected in the D-branes which are the string theory duals of giant loops.

Grignani, Gianluca [Dipartimento di Fisica, Universita di Perugia, INFN Sezione di Perugia, Via A. Pascoli, 06123 Perugia (Italy); Karczmarek, Joanna L.; Semenoff, Gordon W. [Department of Physics and Astronomy, University of British Columbia, Vancouver, British Columbia V6T 1Z1 (Canada)

2010-07-15

237

Supersymmetric Electromagnetic Waves on Giants and Dual-Giants  

E-print Network

We set up the BPS equations for a D3-brane moving in AdS_5 \\times S^5 which preserves two supercharges and with all bosonic fields turned on in the world-volume theory. By solving these, we find generalizations of Mikhailov giants and wobbling dual-giants that include electromagnetic waves propagating on their world-volume. For these giants (dual-giants) we show that the BPS field strength is the real part of the pull-back of a holomorphic 2-form in the ambient space C^3 (C^{1,2}) onto the world-volume.

Sujay K. Ashok; Nemani V. Suryanarayana

2010-04-01

238

Percutaneous balloon mitral valvulotomy and coexisting left atrial hemangioma: case report and long-term follow-up.  

PubMed

Hemangiomas of the heart are extremely rare. The prognosis is quite variable, because this benign tumor may grow, involute, or stop growing; therefore, resection is usually the treatment of choice. In patients with tumors of the left atrium, percutaneous balloon mitral valvulotomy is generally contraindicated. Yet for patients with moderate-to-severe mitral valve stenosis, balloon valvulotomy is an established therapy. Herein, we present the case of a 73-year-old woman who was referred to our department in 1995 with severe mitral valve stenosis. Echocardiography showed a valve orifice area of 0.9 cm2, according to Gorlin's formula, and a mean pressure gradient of 11 mmHg. Surgical therapy was declined by the patient. There were no signs of coronary artery disease. The injection of contrast medium into the left coronary artery showed a hemangioma at the posterior wall of the left atrium. Magnetic resonance imaging and transesophageal echocardiography confirmed the diagnosis. Despite the increased risk posed by the hemangioma, we performed successful percutaneous balloon mitral valvulotomy with an Inoue balloon. We saw the patient in 2001, and again in 2008 when she was 86 years of age. She was in excellent condition, with no signs of relevant dyspnea. Magnetic resonance imaging showed the size of the hemangioma to be stable. By use of echocardiography, we were able to confirm a good long-term result of the balloon valvulotomy. In this patient, a nonsurgical approach was adequate because of the lack of growth of the hemangioma in the left atrium. PMID:20200640

van Buuren, Frank; Langer, Christoph; Faber, Lothar; Butz, Thomas; Schmidt, Henning Karl; Esdorn, Hermann; Bogunovic, Nikola; Mellwig, Klaus Peter; Scholtz, Werner; Horstkotte, Dieter

2010-01-01

239

Hepatic hydrothorax.  

PubMed

Hepatic hydrothorax is defined as a pleural effusion in patients with liver cirrhosis in the absence of cardiopulmonary disease. The estimated prevalence among patients with liver cirrhosis is approximately 5-6%. The pathophysiology involves the passage of ascitic fluid from the peritoneal cavity to the pleural space through diaphragmatic defects. The diagnosis is made from clinical presentation and confirmed by diagnostic thoracentesis with pleural fluid analysis. The initial medical management is sodium restriction and diuretics, but liver transplantation provides the only definitive therapy. For patients who are not transplant candidates and those who await organ availability, other therapeutic modalities that are to be considered include transjugular intrahepatic portosystemic shunt placement, videoassisted thoracoscopic surgery repair, pleurodesis, and vasoconstrictors (eg, octreotide and terlipressin). The primary therapeutic goals are to reduce ascitic fluid production and improve symptoms to bridge the time for liver transplantation. PMID:23085762

Baikati, Kiran; Le, Duong L; Jabbour, Ibrahim I; Singhal, Shashideep; Anand, Sury

2014-01-01

240

Hepatic radiography  

SciTech Connect

The past several years have seen significant advances in diagnostic and interventional radiology. These advances have been particularly rewarding for the study of liver disease. Improved imaging and therapeutic procedures in oncology have generated changes in treatment protocols and in evaluating the results of therapy for hepatic malignancies. The enriched understanding of the anatomic and hemodynamic aspects of the portal system has greatly benefited patients with portal hypertension. Now physicians are confidently more aggressive in the therapeutic approach to the variceal bleeder, and they have modified their approach to the preservation of portal flow following shunt. All of the diagnostic modalities used to evaluate the liver are represented in this book. In its structure and organization this volume goes beyond a historical overview of imaging to present greater insight into the current state of the art, as well as possible future developments. Each chapter is designed to elucidate the advantages and weaknesses of the various diagnostic modalities.

Bernardino, M.E.; Sones, P.J.

1985-01-01

241

Genetics Home Reference: Giant axonal neuropathy  

MedlinePLUS

... literature OMIM Genetic disorder catalog Conditions > Giant axonal neuropathy On this page: Description Genetic changes Inheritance Diagnosis ... definitions Reviewed October 2007 What is giant axonal neuropathy? Giant axonal neuropathy is an inherited condition involving ...

242

Giant European dinosaur found in Spain  

NSDL National Science Digital Library

Fossils of a giant Sauropod, found in Spain, reveal that Europe was home to giant dinosaurs in the Late Jurassic period -- about 150 million years ago. Giant dinosaurs have previously been found mainly in the New World and Africa.

American Association for the Advancement of Science (AAAS;)

2006-12-21

243

A Rare Case of Left Ventricular Intramural Hemangioma Diagnosed Using 1.5-T Cardiac MRI with Histopathological Correlation and Successfully Treated by Surgery  

SciTech Connect

Hemangiomas are vascular tumors composed of blood vessels, frequently localized in the skin and subcutaneous muscles; their localization in the heart is exceptional. The most common localizations are the lateral walls of the left ventricle, the anterior wall, and the septum. Mostly, these tumors grow intracavitarily, rarely intramurally. We describe a singular case of left ventricular intramural hemangioma, detected and diagnosed using newer magnetic resonance imaging (MRI) modalities, confirmed by histopathological results, and treated successfully by surgery.

Marrone, Gianluca, E-mail: gmarrone@ismett.ed [Mediterranean Institute of Transplantation and High Specialization Therapy (ISMETT), Diagnostic and Interventional Radiology (Italy); Sciacca, Sergio, E-mail: ssciacca@ismett.edu; D'Ancona, Giuseppe, E-mail: gdancona@ismett.edu; Pilato, Michele, E-mail: mpilato@ismett.ed [Mediterranean Institute of Transplantation and High Specialization Therapy (ISMETT), Division of Cardiac Surgery (Italy); Luca, Angelo, E-mail: aluca@ismett.ed [Mediterranean Institute of Transplantation and High Specialization Therapy (ISMETT), Diagnostic and Interventional Radiology (Italy); Gridelli, Bruno, E-mail: bgridelli@ismett.ed [Mediterranean Institute of Transplantation and High Specialization Therapy (ISMETT), Division of Surgery (Italy)

2010-02-15

244

Polymyalgia Rheumatica and Giant Cell Arteritis  

MedlinePLUS

Polymyalgia Rheumatica and Giant Cell Arteritis August 2012 Questions and Answers about Polymyalgia Rheumatica and Giant Cell Arteritis This publication contains general information about polymyalgia ...

245

Giant retinal tears.  

PubMed

Of 94 patients (100 eyes) with giant retinal tears, 71.4% of eyes with nontraumatic breaks were myopic and severe retinal pathologic findings were present in 57.3% of fellow eyes. Fifty-five (58%) of 95 treated eyes were successfully reattached; retinal incarceration, attempted in 19 cases, was successful in five. Serious surgical complications were responsible for failure in nine cases (22.5%). The worst prognostic factor were extension of the tear for over two quadrants, myopia of -10 diopters or more, and the presence of aphakia. PMID:1146947

Kanski, J J

1975-05-01

246

Giant spermatic cord liposarcoma.  

PubMed

Abstract We report a case of giant spermatic cord liposarcoma (SCL) in an 81-year-old patient, presenting with a huge scrotal mass that reached up to the knee joint. SCL is a rare tumor, and about 200 cases have been reported in the literature so far. Although 20% of liposarcomas arise in the retroperitoneum, only 0.1% present as incidental inguinal hernias. The occasional presence of myxoid stroma in well-differentiated liposarcomas can lead to confusion with myxoid sarcoma subtypes. Correct diagnosis is critical and reflects remarkable differences in behavior and therapeutic choices. PMID:25058774

Grossi, Ugo; Crucitti, Antonio; Pierconti, Francesco

2014-01-01

247

[Viral hepatitis in travellers].  

PubMed

Considering the geographical asymmetric distribution of viral hepatitis A, B and E, having a much higher prevalence in the less developed world, travellers from developed countries are exposed to a considerable and often underestimated risk of hepatitis infection. In fact a significant percentage of viral hepatitis occurring in developed countries is travel related. This results from globalization and increased mobility from tourism, international work, humanitarian and religious missions or other travel related activities. Several studies published in Europe and North America shown that more than 50% of reported cases of hepatitis A are travel related. On the other hand frequent outbreaks of hepatitis A and E in specific geographic areas raise the risk of infection in these restricted zones and that should be clearly identified. Selected aspects related with the distribution of hepatitis A, B and E are reviewed, particularly the situation in Portugal according to the published studies, as well as relevant clinical manifestations and differential diagnosis of viral hepatitis. Basic prevention rules considering enteric transmitted hepatitis (hepatitis A and hepatitis E) and parenteral transmitted (hepatitis B) are reviewed as well as hepatitis A and B immunoprophylaxis. Common clinical situations and daily practice "pre travel" advice issues are discussed according to WHO/CDC recommendations and the Portuguese National Vaccination Program. Implications from near future availability of a hepatitis E vaccine, a currently in phase 2 trial, are highlighted. Potential indications for travellers to endemic countries like India, Nepal and some regions of China, where up to 30% of sporadic cases of acute viral hepatitis are caused by hepatitis E virus, are considered. Continued epidemiological surveillance for viral hepatitis is essential to recognize and control possible outbreaks, but also to identify new viral hepatitis agents that may emerge as important global health issues. PMID:18331700

Abreu, Cândida

2007-01-01

248

Giant biliary cystadenoma complicated with polycystic liver: A case report  

PubMed Central

Biliary cystadenoma (BCA) is a rare hepatic neoplasm. Although considered a benign cystic tumor of the liver, BCA has a high risk of recurrence with incomplete excision and a potential risk for malignant degeneration. Correct diagnosis and complete tumor excision with negative margins are the mainstay of treatment. Unfortunately, due to the lack of presenting symptoms, and normal laboratory results in most patients, BCA is hard to distinguish from other cystic lesions of the liver such as biliary cystadenocarcinoma, hepatic cyst, hydatid cyst, Caroli disease, undifferentiated sarcoma, intraductal papillary mucinous tumor, and hepatocellular carcinoma. Ultrasound (US), computed tomography (CT) and magnetic resonance imaging (MRI) may be necessary. They demonstrate intrahepatic cystic lesions with features such as mural nodules, varying wall thickness, papillary projections, and internal septations. Nevertheless, surgery is still the only means of accurate diagnosis. Definitive diagnosis requires histological examination following formal resection. We describe a 57-year-old woman initially diagnosed with polycystic liver who was subsequently diagnosed with giant intrahepatic BCA in the left hepatic lobe. This indicates that both US physicians and hepatobiliary specialists should attach importance to hepatic cysts, and CT or MRI should be performed for further examination when a diagnosis of BCA is suspected. PMID:24115833

Yang, Zhen-Zhen; Li, Yong; Liu, Jun; Li, Kuang-Fan; Yan, Ye-Hong; Xiao, Wei-Dong

2013-01-01

249

Giant resonances in Mg-24  

E-print Network

The giant resonance region in Mg-24 was studied with inelastic scattering of 240 MeV alpha particles at small angles including 0 degrees. The giant resonance peak was found to extend up to E-X = 41 MeV. Isoscalar E0, E1, and E2 strength...

Youngblood, David H.; Lui, YW; Clark, HL.

1999-01-01

250

In Search of Giant Squid  

NSDL National Science Digital Library

This site, an online exhibition from the Smithsonian Institution's National Museum of Natural History (NMNH), provides a wealth of background information on Giant Squids. The largest invertebrates on the planet, Giant Squids have aroused human curiosity for centuries. This site offers a plethora of general information about squids and includes a long list of squid links as well.

251

Giant adenoid basal cell carcinoma.  

PubMed

The giant adenoid basal cell carcinoma is an unusual skin tumor that has aggressive biological behavior and has been reported to exhibit geometric growth, deep invasion, and metastasis. A case of giant adenoid basal cell carcinoma is presented, with recommendations for diagnosis and treatment. PMID:8060083

Herring, S M

1994-05-01

252

Radiotherapy of Painful Vertebral Hemangiomas: The Single Center Retrospective Analysis of 137 Cases  

SciTech Connect

Purpose: An evaluation of dose-response relationship and an attempt to define predictive factors. Methods and Materials: A total of 137 cases of painful vertebral hemangioma irradiations (101 patients). Fraction dose (fd) varied from 2 to 15 Gy (123 fractionated and 14 radiosurgical treatments), and total dose (TD) from 8 to 30 Gy (111 cases irradiated with fd of 2 GY to TD of 24 Gy). We evaluated pain relief, changes in analgesic requirements, and reossification. Results: Means of pain relief 1, 6, 12, and 18 months after radiotherapy (defined as a decrease of primary pain level expressed in percent) were 60.5%, 65.4%, 68.3%, and 78.4%, respectively. Proportion of patients with no need for analgesics and patients using tramadol were 39%, 40%, 44%, 57%, and 20%, 17%, 22%, and 11% in these times. The proportion of patients experiencing complete/partial pain relief changed from 36/48% 1 month, to 64/22% 1.5 years after radiotherapy. No impact of radiotherapy on reossification was found. The positive impact of fd and TD increase for analgesics uptake reduction and pain relief was found. An increase of the fd by 1 Gy results in 27% chance of analgesics uptake reduction and 3.8% reduction of pain, whereas 14% analgesics uptake reduction and 2.2% of pain reduction in case of the TD. The predictive factors improving results were found: female gender, older age, better performance states (the chance of the lower analgesic treatment decreases over 2.5 times in comparison to the higher Zubrod degree), bigger Hb concentration, shorter symptoms duration and lower analgesics uptake before radiotherapy. Conclusions: The obtained data support the efficacy of radiotherapy in improving pain secondary to vertebral hemangioma, with the degree of pain amelioration being related to increasing fd and TD. The positive predictive factors were defined: female gender, older age, better performance status, increased Hb concentration, shorter symptoms duration, and lower analgesics uptake before radiotherapy.

Miszczyk, Leszek, E-mail: leszek@io.gliwice.pl [Radiotherapy Department, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice (Poland); Tukiendorf, Andrzej [Cardiff Research Consortium, The MediCentre Eastgate House, Cardiff, South Glamorgan (United Kingdom)

2012-02-01

253

Hepatic abscesses  

PubMed Central

Hepatic abscesses are potentially lethal diseases if early diagnosis and treatment are not instituted. They are prevalent all over the globe and pyogenic abscesses are predominant over amoebic. With better control of intra abdominal and systemic infections by a spectrum of antibiotics, aetiology of pyogenic abscesses are secondary to interventions and diseases in the biliary tree to a large extent today. The common organisms isolated are the Gram negative group. Amoebic abscesses continue to plague some regions of the world where hygiene and sanitation are questionable. Over the years, diagnosis, treatment and prognosis have evolved remarkably. Imaging modalities like ultrasonography and CT scan have become the cornerstone of diagnosis. The absence of ionizing radiation makes MRI an attractive alternative in patients who require multiple follow up scans. Serological testing in amoebic abscesses has become more reliable. Though antibiotics have remained the principal modality of management, percutaneous drainage of abscesses have vastly improved the chances of cure and bring down the morbidity drastically in pyogenic abscesses. Amoebic abscesses respond well to medical treatment with nitroimidazoles, and minimally invasive surgical drainage is an option in cases where open surgery is indicated. PMID:24532886

Rajagopalan, S.; Langer, V.

2012-01-01

254

Hepatitis C (image)  

MedlinePLUS

Hepatitis C is a virus-caused liver inflammation which may cause jaundice, fever and cirrhosis. Persons who are most at risk for contracting and spreading hepatitis C are those who share needles for injecting drugs ...

255

From Gravitons to Giants  

E-print Network

We discuss exact quantization of gravitational fluctuations in the half-BPS sector around AdS$_5 \\times $S$^5$ background, using the dual super Yang-Mills theory. For this purpose we employ the recently developed techniques for exact bosonization of a finite number $N$ of fermions in terms of $N$ bosonic oscillators. An exact computation of the three-point correlation function of gravitons for finite $N$ shows that they become strongly coupled at sufficiently high energies, with an interaction that grows exponentially in $N$. We show that even at such high energies a description of the bulk physics in terms of weakly interacting particles can be constructed. The single particle states providing such a description are created by our bosonic oscillators or equivalently these are the multi-graviton states corresponding to the so-called Schur polynomials. Both represent single giant graviton states in the bulk. Multi-particle states corresponding to multi-giant gravitons are, however, different, since interactions among our bosons vanish identically, while the Schur polynomials are weakly interacting at high enough energies.

Avinash Dhar; Gautam Mandal; Mikael Smedbäck

2005-12-26

256

Giant papillary conjunctivitis.  

PubMed Central

Giant papillary conjunctivitis is a syndrome found frequently as a complication of contact lenses. Many variables can affect the onset and severity of the presenting signs and symptoms. Rigid gas permeable contact lenses appear to result in less severe signs and symptoms, with a longer time before the development of giant papillary conjunctivitis. Nonionic, low-water-content soft contact lenses tend to produce less severe signs and symptoms than ionic, low-water-content soft contact lenses. Enzymatic treatment appears to lessen the severity of signs and symptoms. The association of an allergy appears to play a role in the onset of the severity of the signs and symptoms but does not appear to affect the final ability of the individual to wear contact lenses. Using multiple treatment options, such as changing the polymer to a glyceryl methyl methacrylate or a rigid lens, or utilizing a soft lens on a frequent-replacement basis, can result in a success rate of over 90%. In individuals who still have a return of symptoms, the use of topical mast cell stabilizers or a nonsteroidal anti-inflammatory drug as an adjunctive therapy offers the added possibility of keeping these patients in contact lenses. Images FIGURE 1 FIGURE 2 FIGURE 3 FIGURE 4 FIGURE 5 FIGURE 6 FIGURE 7 FIGURE 11 A FIGURE 11 B FIGURE 11 C FIGURE 11 D PMID:7886881

Donshik, P C

1994-01-01

257

Color Doppler sonography and resistivity index in the differential diagnosis of hepatic neoplasm.  

PubMed

The purpose of this study was to determine the usefulness of color doppler sonography and resistivity index (RI) in differentiating liver tumors. The study was carried out in the Department of Radiology and Imaging, Mymensingh Medical College Hospital, and Institute of Nuclear Medicine and Allied Sciences (INMAS), Mymensingh, Bangladesh, during the period of July 2009 to June 2011. Total 50 consecutive cases were studied. Among them 27 were hepatocellular carcinomas, 19 were metastatic tumors, 03 were hemangiomas and 01 was hepatic adenoma. Doppler sonographic findings were then correlated, case by case, with final diagnosis- either pathologically by USG guided Fine-needle aspiration or by other imaging modalities (e.g., CT scan and RBC liver scan for hepatic hemangioma). The RI value of hepatocellular carcinoma was 0.69±0.096 and in metastatic tumors 0.73±0.079. The results showed no significant difference between the RI of hepatocellular carcinomas and metastatic liver tumors but it was significantly higher than benign lesions (p<0.05). RI of hemangiomas was 0.49±0.64 and in one hepatic adenoma was 0.65. When RI was <0.6 for benign liver tumors and ?0.6 for malignant tumors we calculated a sensitivity of 89.14%, specificity of 66.7%, accuracy of 85.71% positive predictive value of 97.62% and negative predictive value of 28.57% in differentiating benign and malignant tumors. Thirty four of 46(73.9%) malignant lesions had intratumoral flow and 25% of benign lesions also showed intratumoral flow. The difference of intratumoral flow between malignant and benign lesions was significant (p<0.01). Two of 4 benign lesions (50%) had peritumoral vascularity where 6% of the malignant tumors showed peritumoral vascularity. In conclusion, combined studies of the type of intra-and peri-tumoral flow signals in CDFI and the parameter of RI would be more helpful in the differential diagnosis of benign and malignant liver tumors. PMID:24584370

Nahar, N; Khan, N; Chakraborty, R K; Rima, S Z; Ara, R; Islam, S M; Mahmud, S; Alam, M N; Swapan, K; Akhter, M; Saleh, F M; Alam, M M; Alam, M M

2014-01-01

258

Allometry indicates giant eyes of giant squid are not exceptional  

PubMed Central

Background The eyes of giant and colossal squid are among the largest eyes in the history of life. It was recently proposed that sperm whale predation is the main driver of eye size evolution in giant squid, on the basis of an optical model that suggested optimal performance in detecting large luminous visual targets such as whales in the deep sea. However, it is poorly understood how the eye size of giant and colossal squid compares to that of other aquatic organisms when scaling effects are considered. Results We performed a large-scale comparative study that included 87 squid species and 237 species of acanthomorph fish. While squid have larger eyes than most acanthomorphs, a comparison of relative eye size among squid suggests that giant and colossal squid do not have unusually large eyes. After revising constants used in a previous model we found that large eyes perform equally well in detecting point targets and large luminous targets in the deep sea. Conclusions The eyes of giant and colossal squid do not appear exceptionally large when allometric effects are considered. It is probable that the giant eyes of giant squid result from a phylogenetically conserved developmental pattern manifested in very large animals. Whatever the cause of large eyes, they appear to have several advantages for vision in the reduced light of the deep mesopelagic zone. PMID:23418818

2013-01-01

259

Hepatitis E in pregnancy  

Microsoft Academic Search

Objectives: To study the spectrum and the clinical and biochemical course of viral hepatitis E during pregnancy. Methods: In this prospective study, sera of 62 pregnant women having jaundice in the third trimester of pregnancy were analyzed for markers of hepatitis A, B, C and E viruses. The cord blood samples of hepatitis E virus (HEV)-positive pregnant women at the

A. Kumar; M. Beniwal; P. Kar; J. B. Sharma; N. S. Murthy

2004-01-01

260

Diagnosis of sclerosing hemangioma of lung: don't rely on fine-needle aspiration cytology diagnosis alone.  

PubMed

Sclerosing hemangioma is a rare variety of benign pulmonary neoplasm. It usually presents as asymptomatic, solitary, peripheral, circumscribed lesions in middle-aged women. Here, we describe a 46-year-old woman presenting to us for evaluation of right parahilar lung mass. Previous chest radiography done 10 years back showed a lung mass of almost similar size. Computed Tomography (CT)-guided fine-needle aspiration cytology (FNAC) was suggestive of adenocarcinoma of lung. A well-circumscribed, capsulated, ovoid mass measuring 5.6 cm × 4 cm × 3 cm, adjacent to the transverse fissure of the right lung was excised by lateral thoracotomy. Histopathological examination along with immunohistochemistry was suggestive of sclerosing hemangioma of lung. A pathologist must consider the clinicoradiological features before coming to a final diagnosis of lung malignancy from FNAC. Whenever there is any confusion regarding lung mass, thoracotomy must be done for arriving at an exact diagnosis from histopathology. PMID:24518736

Saha, Kaushik; Sit, Niranjan Kr; Jash, Debraj; Maji, Arnab

2013-01-01

261

Intractable hiccup as the presenting symptom of cavernous hemangioma in the medulla oblongata: a case report and literature review.  

PubMed

A case of intractable hiccup developed by cavernous hemangioma in the medulla oblongata is reported. There have been only five previously reported cases of medullary cavernoma that triggered intractable hiccup. The patient was a 28-year-old man who was presented with intractable hiccup for 15 days. It developed suddenly, then aggravated progressively and did not respond to any types of medication. On magnetic resonance images, a well-demarcated and non-enhancing mass with hemorrhagic changes was noted in the left medulla oblongata. Intraoperative findings showed that the lesion was fully embedded within the brain stem and pathology confirmed the diagnosis of cavernous hemangioma. The hiccup resolved completely after the operation. Based on the presumption that the medullary cavernoma may trigger intractable hiccup by displacing or compression the hiccup arc of the dorsolateral medulla, surgical excision can eliminate the symptoms, even in the case totally buried in brainstem. PMID:25237438

Lee, Kyung-Hwa; Moon, Kyung-Sub; Jung, Min-Young; Jung, Shin

2014-06-01

262

Strawberry Hemangioma  

MedlinePLUS

... Notice This Site and third parties who place advertisements on this Site may collect and use information ... Site and other websites in order to provide advertisements about goods and services of interest to you. ...

263

Clinical observation on the treatment of hemangioma by CO2 laser supplemented with He-Ne laser  

NASA Astrophysics Data System (ADS)

Sixty-six cases of hemangioma were treated with CO2 laser alone (22 cases as a control group), or CO2 laser supplemented with He-Ne laser (44 cases of the treated group). Optimum power dosage was first sought on normal volunteers. Arteriolar vasculature and lymphatics were blocked 3 - 5 times with procaine hydrochloride (5:1) to minimize local blood congestion. Results show that the healing rate of the treated group was significantly higher than that of the control group (X3 equals 3.92, P < 0.05). Eleven cases (50%) were complicated with exudation in the control as compared with 3 cases (6.8%) in the treated group (P < 0.01). Of the 18 cases completely cured in the control group, the number of treatments averaged at 11.4 times, while of the 39 cases completely cured in the treated group, the average number of treatments was 5.9 times, which is also statistically significant (P < 0.01). It is considered that CO2 laser supplemented with He-Ne laser is superior than CO2 laser alone for the treatment of hemangioma. Furthermore, it is also proposed that the supplement of copper and Chinese herbal medicines may prevent the incidence of recurrence. Laser was used for the treatment of hemangioma in our country during the 1980s. In foreign literature, there were several reports using Nd:YAG and copper vapor laser for the treatment of agniomasimplex and nevus flammeus. Ar+ laser agglomeration was commonly used for the treatment of angioma conjunctive in our country, but the use of CO2 laser for the treatment of angioma epiderma is not well documented. We wish to report the use of CO2 laser supplemented with He-Ne laser for the treatment of hemangioma in our hospital from April 1988 to December 1989.

Zhao, Zhigui

1993-03-01

264

Giant magnetostrictive composites  

NASA Astrophysics Data System (ADS)

The limitation of magnetostrictive composites has been in their low magnetostrictive response when compared to their monolithic counterparts. In this dissertation research is presented describing the methods and analysis used to create a giant magnetostrictive composite (GMC) producing giant strains at low fields, exhibiting magnetization ``jumping'' and the ?E effect. This composite combines the giant magnetostrictive material, Terfenol-D (Tb0.3Dy0.7Fe2) in particle form, with a nonmetallic binder and is capable of producing strains (at room temperature) exceeding 1000 ppm at a nominal field of 1.5 kOe mechanically unloaded and 1200 ppm at 8 MPa preload (2.5 kOe). Several studies leading to the high response of this composite are presented. A connectivity study shows that a [1-3] connected composite produces 50% more strain than a [0-3] composite. A resin study indicates that the lower the viscosity of the resin, the greater the magnetostrictive response; this is attributed to the removal of voids during degassing. A void study correlates the increase in voids to the decrease in strain response. A model is used to correlate analysis with experimental results within 10% accuracy and shows that an optimal volume fraction exists based on the properties of the binder. Using a Polyscience Spurr low- viscosity (60 cps) binder this volume fraction is nominally 20%; this optimum is attributed to the balance of epoxy contracting on the particle (built-in preload) and the actuation delivered by the magnetostrictive material. In addition to the connectivity, resin, void, and volume-fraction study, particle size and gradation studies are presented. Widely dispersed (<106, <212, <300 ?m), narrowly dispersed (<45, (90-106), (275-300) ?m), and an optimized bimodal (18.7% of (45-90) ?m with 81.3% of (250-300) ?m) particle distributions are studied. Results show that the larger the particle size, the higher the magnetostrictive response; this is attributed to the reduction of demagnetizing effects. Results also show that the wider the distribution, the higher the magnetostrictive response and is attributed to the increase in packing density. Using a bimodal optimized distribution, both large particle response as well as superior packing is achieved resulting in a material that produces the largest magnetostriction reported for low fields.

Duenas, Terrisa Ann

265

Giant magnetofossils and hyperthermal events  

NASA Astrophysics Data System (ADS)

Magnetotactic bacteria biomineralize magnetic minerals with precisely controlled size, morphology, and stoichiometry. These cosmopolitan bacteria are widely observed in aquatic environments. If preserved after burial, the inorganic remains of magnetotactic bacteria act as magnetofossils that record ancient geomagnetic field variations. They also have potential to provide paleoenvironmental information. In contrast to conventional magnetofossils, giant magnetofossils (most likely produced by eukaryotic organisms) have only been reported once before from Paleocene-Eocene Thermal Maximum (PETM; 55.8 Ma) sediments on the New Jersey coastal plain. Here, using transmission electron microscopic observations, we present evidence for abundant giant magnetofossils, including previously reported elongated prisms and spindles, and new giant bullet-shaped magnetite crystals, in the Southern Ocean near Antarctica, not only during the PETM, but also shortly before and after the PETM. Moreover, we have discovered giant bullet-shaped magnetite crystals from the equatorial Indian Ocean during the Mid-Eocene Climatic Optimum (˜40 Ma). Our results indicate a more widespread geographic, environmental, and temporal distribution of giant magnetofossils in the geological record with a link to "hyperthermal" events. Enhanced global weathering during hyperthermals, and expanded suboxic diagenetic environments, probably provided more bioavailable iron that enabled biomineralization of giant magnetofossils. Our micromagnetic modelling indicates the presence of magnetic multi-domain (i.e., not ideal for navigation) and single domain (i.e., ideal for navigation) structures in the giant magnetite particles depending on their size, morphology and spatial arrangement. Different giant magnetite crystal morphologies appear to have had different biological functions, including magnetotaxis and other non-navigational purposes. Our observations suggest that hyperthermals provided ideal conditions for giant magnetofossils, and that these organisms were globally distributed. Much more work is needed to understand the interplay between magnetofossil morphology, climate, nutrient availability, and environmental variability.

Chang, Liao; Roberts, Andrew P.; Williams, Wyn; Fitz Gerald, John D.; Larrasoaña, Juan C.; Jovane, Luigi; Muxworthy, Adrian R.

2012-10-01

266

Preoperative Sclerotherapy Using Sodium Tetradecyl Sulphate (Fibro-Vein(TM)) Can Assist in the Management of Vertebral Hemangiomas  

PubMed Central

Vertebral hemangiomas are benign lesions accounting for 2 to 3% of all spinal tumors. They are usually asymptomatic and found incidentally on imaging. Uncommonly, vertebral hemangiomas with significant epidural extension can result in radiculopathy or spinal cord compression. Decompressive surgery with or without stabilization is often required when neurological deficits are present. However, surgery can be associated with massive hemorrhage as these tumors are hypervascular. Preoperative embolization and sclerotherapy are well-known management strategies used to minimize intraoperative bleeding and improve symptoms. Recently, the use of sclerosants such as ethanol has decreased, due to reported complications such as Brown–Sequard syndrome. We describe the use of sodium tetradecyl sulfate (Fibro-Vein™, STD Pharmaceutical, Hereford, UK) as an effective alternative to ethanol in the preoperative management of vertebral hemangiomas. To our knowledge, this has not been previously reported. In three patients, we demonstrated minimal intraoperative blood loss using a combination of preoperative embolization of arterial feeders and sclerotherapy with sodium tetradecyl sulfate to control and secure venous drainage. No patients developed complications related to the procedure. In addition to minimal blood loss, a clear dissection plane was also noted intraoperatively. PMID:24353964

Damodaran, Omprakash; McAuliffe, Will; Wong, George; McCloskey, Eamonn; Lee, Gabriel

2012-01-01

267

Preoperative sclerotherapy using sodium tetradecyl sulphate (fibro-vein™) can assist in the management of vertebral hemangiomas.  

PubMed

Vertebral hemangiomas are benign lesions accounting for 2 to 3% of all spinal tumors. They are usually asymptomatic and found incidentally on imaging. Uncommonly, vertebral hemangiomas with significant epidural extension can result in radiculopathy or spinal cord compression. Decompressive surgery with or without stabilization is often required when neurological deficits are present. However, surgery can be associated with massive hemorrhage as these tumors are hypervascular. Preoperative embolization and sclerotherapy are well-known management strategies used to minimize intraoperative bleeding and improve symptoms. Recently, the use of sclerosants such as ethanol has decreased, due to reported complications such as Brown-Sequard syndrome. We describe the use of sodium tetradecyl sulfate (Fibro-Vein™, STD Pharmaceutical, Hereford, UK) as an effective alternative to ethanol in the preoperative management of vertebral hemangiomas. To our knowledge, this has not been previously reported. In three patients, we demonstrated minimal intraoperative blood loss using a combination of preoperative embolization of arterial feeders and sclerotherapy with sodium tetradecyl sulfate to control and secure venous drainage. No patients developed complications related to the procedure. In addition to minimal blood loss, a clear dissection plane was also noted intraoperatively. PMID:24353964

Damodaran, Omprakash; McAuliffe, Will; Wong, George; McCloskey, Eamonn; Lee, Gabriel

2012-09-01

268

Simultaneous diagnosis of ipsilateral adenoid cystic carcinoma of the lacrimal gland and orbital cavernous hemangioma: case report.  

PubMed

To describe a patient with coexistence of ipsilateral adenoid cystic carcinoma of the lacrimal gland and orbital cavernous hemangioma. The patient presented a 2-month history of painful swelling of left upper eyelid, which did not resolve on a course of oral steroid. On clinical examination, she had moderate medial and inferior dislocation of the eye globe, edema of the temporal superior eyelid and moderate restriction upgaze. Magnetic resonance imaging identified two left orbital tumors: one was a lesion that arose from the lacrimal gland, and the second was a well-defined, ovoid, intraconal mass. The patient underwent lateral orbitotomy and excision of both lesions. Postoperative histological features demonstrated two different lesions: an adenoid cystic carcinoma of the lacrimal gland and a cavernous hemangioma. The clinical presentation of the present case was strongly suggestive of a lacrimal gland malignancy, although the imaging features did not show typical invasive aspects. This is the first report of coexistence of lacrimal gland adenoid cystic carcinoma and cavernous hemangioma in the ipsilateral orbit. PMID:24786224

Strianese, Diego; Ferrara, Mariantonia; Iuliano, Adriana; Bonavolontà, Giulio

2014-08-01

269

Congenital giant axonal neuropathy.  

PubMed

Giant axonal neuropathy (GAN) is a distal sensorimotor neuropathy, characterized by neurofilamentous axonal swellings, with usual onset at 2 to 3 years of age. We report a case of congenital GAN with hypotonia at birth. At 7 months of age, nerve conduction studies showed almost complete lack of sensory and motor responses in the lower extremities. A sural nerve biopsy specimen disclosed absence of myelinated axons. Autopsy, following death at 15 months of age, revealed axonal swellings in peripheral nerves and distal degeneration of long spinal cord tracts. The neurofilamentous content of the axonal swellings was confirmed by Glees-Marsland staining and immunoperoxidase reaction with antibodies to neurofilaments. Axonal swellings did not stain with periodic acid-Schiff and were not seen in the cerebral cortex or brain stem, distinguishing this process from infantile neuroaxonal dystrophy. This patient illustrates congenital GAN with subsequent rapid progression. PMID:2990373

Kinney, R B; Gottfried, M R; Hodson, A K; Autilio-Gambetti, L; Graham, D G

1985-07-01

270

Giant facial lymphangioma.  

PubMed

Lymphatic malformation (LM) is a benign cystic entity resulting from aberrant lymphatic drainage. Often evident at birth, most LMs have declared themselves by 2 years of age. They can be concerning when they occur near vital structures such as the airway or orbit. The natural history varies considerable from spontaneous gradual regression to long-term growth and debilitation. Depending on the location, structures involved, and clinical course of the LM, therapeutic options include observation, intralesional sclerosis, laser therapy, and surgical excision. The literature provides guidelines for treatment options that must be carefully applied to the facial region. We present a newborn infant who presented to our institution with giant facial lymphangioma who underwent a combination of sclerosis, laser ablation, and surgery with reconstruction. PMID:21772195

Sanger, Claire; Wong, Lindsey; Wood, Jeyhan; David, Lisa R; Argenta, Louis C

2011-07-01

271

[Giant adrenal myelolipoma].  

PubMed

Adrenal myelolipoma is a rare, benign, non-secreting tumour composed of adipose and haematopoietic tissue. The authors report a rare case of giant adrenal myelolipoma in a 53-year-old patient presenting with low back pain and a palpable flank mass on examination. CT scan suggested the diagnosis and surgical resection was indicated in view of the size and symptomatic nature of this mass. Histological examination confirmed the diagnosis. The outcome was favourable without recurrence after a follow-up of one year. The diagnosis of adrenal myelolipoma is based on radiology. Conservative management is generally sufficient for small asymptomatic tumours, but resection is required for large (> 5 cm) and/or symptomatic tumours. PMID:15098761

El Mejjad, Amine; Fekak, Hamid; Dakir, Mohamed; Sarf, Ismail; Manni, Ahmed; Meziane, Fethi

2004-02-01

272

Giant Hedge-Hogs: Spikes on Giant Gravitons  

SciTech Connect

We consider giant gravitons on the maximally supersymmetric plane-wave background of type IIB string theory. Fixing the light-cone gauge, we work out the low energy effective light-cone Hamiltonian of the three-sphere giant graviton. At first order, this is a U(1) gauge theory on R x S{sup 3}. We place sources in this effective gauge theory. Although non-vanishing net electric charge configurations are disallowed by Gauss' law, electric dipoles can be formed. From the string theory point of view these dipoles can be understood as open strings piercing the three-sphere, generalizing the usual BIons to the giant gravitons, BIGGons. Our results can be used to give a two dimensional (worldsheet) description of giant gravitons, similar to Polchinski's description for the usual D-branes, in agreement with the discussions of hep-th/0204196.

Sadri, D

2004-01-28

273

A giant Ordovician anomalocaridid.  

PubMed

Anomalocaridids, giant lightly sclerotized invertebrate predators, occur in a number of exceptionally preserved early and middle Cambrian (542-501?million years ago) biotas and have come to symbolize the unfamiliar morphologies displayed by stem organisms in faunas of the Burgess Shale type. They are characterized by a pair of anterior, segmented appendages, a circlet of plates around the mouth, and an elongate segmented trunk lacking true tergites with a pair of flexible lateral lobes per segment. Disarticulated body parts, such as the anterior appendages and oral circlet, had been assigned to a range of taxonomic groups--but the discovery of complete specimens from the middle Cambrian Burgess Shale showed that these disparate elements all belong to a single kind of animal. Phylogenetic analyses support a position of anomalocaridids in the arthropod stem, as a sister group to the euarthropods. The anomalocaridids were the largest animals in Cambrian communities. The youngest unequivocal examples occur in the middle Cambrian Marjum Formation of Utah but an arthropod retaining some anomalocaridid characteristics is present in the Devonian of Germany. Here we report the post-Cambrian occurrence of anomalocaridids, from the Early Ordovician (488-472?million years ago) Fezouata Biota in southeastern Morocco, including specimens larger than any in Cambrian biotas. These giant animals were an important element of some marine communities for about 30?million years longer than previously realized. The Moroccan specimens confirm the presence of a dorsal array of flexible blades attached to a transverse rachis on the trunk segments; these blades probably functioned as gills. PMID:21614078

Van Roy, Peter; Briggs, Derek E G

2011-05-26

274

Giant hedge-hogs: spikes on giant gravitons  

Microsoft Academic Search

We consider giant gravitons on the maximally supersymmetric plane-wave background of type IIB string theory. Fixing the light-cone gauge, we deduce the low energy effective light-cone Hamiltonian of the three-sphere giant graviton. At first order, this is a U(1) gauge theory on R×S3. We place sources in this effective gauge theory. Although non-vanishing net electric charge configurations are disallowed by

Darius Sadri; M. M. Sheikh-Jabbari

2004-01-01

275

[Hepatitis A in Oslo].  

PubMed

During the last six years we have registered 237 persons with acute hepatitis A in Oslo, 96 of them with non-Scandinavian names. The number with non-Scandinavian names is increasing. Almost all the hepatitis A patients with non-Scandinavian names are children, and two of three had been infected in Pakistan. Adult immigrants from countries where hepatitis A is endemic do not need any prophylaxis against hepatitis A. 29,800 travellers were given human normal immunoglobulin at our department during the last five years and none of them acquired hepatitis A. To prevent import of hepatitis A it is of particular importance to give human normal immunoglobulin or hepatitis A vaccine to all children of immigrants before they visit their parents' country. PMID:7855814

Hasle, G; Espinoza, R

1995-01-20

276

Theories of Giant Planet Formation  

NASA Technical Reports Server (NTRS)

An overview of current theories of planetary formation, with emphasis on giant planets, is presented. The most detailed models are based upon observations of our own Solar System and of young stars and their environments. While these models predict that rocky planets should form around most single stars, the frequency of formation of gas giant planets is more difficult to predict theoretically. Terrestrial planets are believed to grow via pairwise accretion until the spacing of planetary orbits becomes large enough that the configuration is stable for the age of the system. Giant planets begin their growth as do terrestrial planets, but they become massive enough that they are able to accumulate substantial amounts of gas before the protoplanetary disk dissipates. Most models for extrasolar giant planets suggest that they formed as did Jupiter and Saturn (in nearly circular orbits, far enough from the star that ice could), and subsequently migrated to their current positions, although some models suggest in situ formation.

Lissauer, Jack J.; Young, Richard E. (Technical Monitor)

1998-01-01

277

Landscape of the lost giants  

NASA Astrophysics Data System (ADS)

The Pleistocene megafauna extinction erased a group of remarkable animals. Whether humans had a prominent role in the extinction remains controversial, but it is emerging that the disappearance of the giants has markedly affected the environment.

2013-09-01

278

Alcoholic hepatitis.  

PubMed

Alcoholic hepatitis (AH) is an acute inflammatory syndrome causing significant morbidity and mortality. The prognosis is strongly dependent on disease severity, as assessed by clinical scoring systems. Reliable epidemiological data as well as knowledge of the clinical course of AH are essential for planning and resource allocation within the health care system. Likewise, individual evaluation of risk is desirable in the clinical handling of patients with AH as it can guide treatment, improve patient information, and serve as strata in clinical trials. The present PhD thesis is based on three studies using a cohort of nearly 2000 patients diagnosed with AH in Denmark from 1999 to 2008 as a cohort, in a population-based study design. The aims of this thesis were as follows. (1) To describe the incidence and short- and long-term mortality, of AH in Denmark (Study I). (2) To validate and compare the ability of the currently available prognostic scores to predict mortality in AH (Study II). (3) To investigate the short- and long-term causes of death of patients with AH (Study III). During the study decade, the annual incidence rate in the Danish population rose from 37 to 46 per 106 for men and from 24 to 34 per 106 for women. Both short- and long-term mortality rose for men and women, and the increase in short-term mortality was attributable to increasing patient age and prevalence of cirrhosis. Our evaluation of the most commonly used prognostic scores for predicting the mortality of patients with AH showed that all scores performed similarly, with Area under the Receiver Operator Characteristics curves giving values between 0.74 and 0.78 for 28-day mortality assessed on admission. Our study on causes of death showed that in the short-term (< 84 days after diagnosis), patients with AH were likely to die from liver-related events and infections. In the long-term (? 84 days after diagnosis), those who developed cirrhosis mainly died from liver-related causes, and those who did not develop cirrhosis mainly died from causes related to alcohol abuse. In conclusion, the present thesis provides novel warranted epidemiological information about AH that shows increasing incidence and mortality rates. Consequently, it reiterates the fact that AH is a life-threatening disease and suggests that AH is an increasing public health concern. The most widely used prognostic models may be helpful adjuvants in the routine management of patients with AH, provided that clinicians are aware of the models' limitations. The causes of death in AH are primarily due to liver-related complications, suggesting that patients with AH could benefit from continued follow-up by a hepatologist after the acute episode. PMID:25283626

Sandahl, Thomas Damgaard

2014-10-01

279

Kuiper Prize: Giant Planet Atmospheres  

NASA Astrophysics Data System (ADS)

The study of giant planet atmospheres is near and dear to me, for several reasons. First, the giant planets are photogenic; the colored clouds are great tracers, and one can make fantastic movies of the atmosphere in motion. Second, the giant planets challenge us with storms that last for hundreds of years and winds that blow faster the farther you go from the sun. Third, they remind us of Earth with their hurricanes, auroras, and lightning, but they also are the link to the 200 giant planets that have been discovered around other stars. This talk will cover the past, present, and future (one hopes) of giant planet research. I will review the surprises of the Voyager and Galileo eras, and will discuss what we are learning now from the Cassini orbiter. I will review the prospects for answering the outstanding questions like: Where's the water? What is providing the colors of the clouds? How deep do the features extend? Where do the winds get their energy? What is the role of the magnetic field? Finally, I will briefly discuss how extrasolar giant planets compare with objects in our own solar system.

Ingersoll, Andrew P.

2007-10-01

280

Giant magnetoresistance in multilayers  

NASA Astrophysics Data System (ADS)

We studied ballistic conductance in the current perpendicular-to-the-plane geometry (CPP) in various types of multilayer systems. The goal was to see to what extent the band structure matching in these multilayer systems is responsible for the giant magneto-resistance effect (GMR) and how GMR depends on the various parameters of the samples. The band structure was taken into account through a realistic third-nearest-neighbor tight-binding model with s, p and d orbitals. The Landauer formula was used to calculate the conductance of the two spin channels. The method is based on efficiently calculating the Green's function of the leads and the slab using the transfer matrix approach. Using this framework we studied the dependence of GMR on the size of the spacer and magnetic slabs and the number of periods in conventional multilayers. The ballistic conductance and GMR were found to saturate quickly with the number of periods in the multilayer. Next, we investigated the angular dependence of the conductance and giant magnetoresistance in spin-valve structures. The conductance, due to both minority and majority spin channels, was calculated for arbitrary angles between the magnetizations of the magnetic layers. We found that the leading contribution to the conductance is proportional to the cosine of the angle between the magnetizations of the magnetic layers. Next, we present theoretical studies on the size-dependence of the CPP GMR in nanowires. We find that the conductance of the minority channel in the parallel configuration increases very slowly with the nanowire size. At the same time, the conductance of all other channels reaches the value observed in multilayers at very small nanowire size. This limits the GMR ratio to only a fraction of the multilayer value for small nanowires. Finally, we study the dependence of GMR on the size of the nanowire for medium size nanowires. We propose a scheme exploiting the symmetry of the wire to break the problem into several disconnected problems for the different symmetry type wave functions, which can live on the wire.

Velev, Julian Petkov

281

Feature Hepatitis: Hepatitis Symptoms, Diagnosis, Treatment & Prevention  

MedlinePLUS

... booster dose six to 12 months following the initial dose of vaccine. The vaccine is thought to ... patients with chronic hepatitis C recovered after receiving initial treatments from two drugs, peginterferon and ribavirin. Spring ...

282

Feature Hepatitis: Hepatitis Can Strike Anyone  

MedlinePLUS

... please turn Javascript on. From Hollywood's "Walk of Stars" to Main Street, USA, people from all walks ... that includes many well-known names: Legendary television star Larry Hagman was diagnosed with advanced hepatitis C ...

283

Autophagy in Hepatic Fibrosis  

PubMed Central

Hepatic fibrosis is a leading cause of morbidity and mortality worldwide. Hepatic fibrosis is usually associated with chronic liver diseases caused by infection, drugs, metabolic disorders, or autoimmune imbalances. Effective clinical therapies are still lacking. Autophagy is a cellular process that degrades damaged organelles or protein aggregation, which participates in many pathological processes including liver diseases. Autophagy participates in hepatic fibrosis by activating hepatic stellate cells and may participate as well through influencing other fibrogenic cells. Besides that, autophagy can induce some liver diseases to develop while it may play a protective role in hepatocellular abnormal aggregates related liver diseases and reduces fibrosis. With a better understanding of the potential effects of autophagy on hepatic fibrosis, targeting autophagy might be a novel therapeutic strategy for hepatic fibrosis in the near future. PMID:24779010

Zhao, Yingying; Wang, Fei; Tao, Lichan; Yang, Changqing

2014-01-01

284

A unique advantage for giant eyes in giant squid.  

PubMed

Giant and colossal deep-sea squid (Architeuthis and Mesonychoteuthis) have the largest eyes in the animal kingdom [1, 2], but there is no explanation for why they would need eyes that are nearly three times the diameter of those of any other extant animal. Here we develop a theory for visual detection in pelagic habitats, which predicts that such giant eyes are unlikely to evolve for detecting mates or prey at long distance but are instead uniquely suited for detecting very large predators, such as sperm whales. We also provide photographic documentation of an eyeball of about 27 cm with a 9 cm pupil in a giant squid, and we predict that, below 600 m depth, it would allow detection of sperm whales at distances exceeding 120 m. With this long range of vision, giant squid get an early warning of approaching sperm whales. Because the sonar range of sperm whales exceeds 120 m [3-5], we hypothesize that a well-prepared and powerful evasive response to hunting sperm whales may have driven the evolution of huge dimensions in both eyes and bodies of giant and colossal squid. Our theory also provides insights into the vision of Mesozoic ichthyosaurs with unusually large eyes. PMID:22425154

Nilsson, Dan-Eric; Warrant, Eric J; Johnsen, Sönke; Hanlon, Roger; Shashar, Nadav

2012-04-24

285

A review of contemporary options for medical management of hemangiomas, other vascular tumors, and vascular malformations.  

PubMed

Vascular anomalies include vascular tumors and vascular malformations. With growing pharmacologic options and parallels to cancer treatment and biology, the hematologist-oncologist has assumed a more prominent role in clinical care and research relating to these diagnoses. This also is a growing area for targeted therapies and drug repositioning. We performed a review of contemporary options for medical management of these lesions. PubMed was searched for "vascular anomaly", "hemangioma", "vascular malformation", "arteriovenous malformation", "capillary malformation", "cerebral cavernous malformation", "lymphatic malformation", and "venous malformation", each with "drug treatment" as a modifier. Manuscripts were reviewed to verify diagnoses, indications for treatment, dose-schedules, evidence of effectiveness, toxicities, and mechanisms of action. ClinicalTrials.gov also was reviewed for relevant trials. More than 20 agents were identified which have been used to treat vascular anomalies. Rigorous studies are lacking for many of these. The rarity of these tumors has limited development of medical approaches to treatment. Cooperative group trials will be needed to prove the effectiveness of drugs which have shown promise in cases and small series. The observant clinician remains a powerful tool for identifying potential new treatments for vascular tumors and malformations. PMID:23665062

Blatt, Julie; McLean, Thomas W; Castellino, Sharon M; Burkhart, Craig N

2013-09-01

286

ZFP36-FOSB Fusion Defines a Subset of Epithelioid Hemangioma with Atypical Features  

PubMed Central

Epithelioid hemangioma (EH) is a benign neoplasm with distinctive vasoformative features, which occasionally shows increased cellularity, cytologic atypia, and/or loco-regional aggressive growth, resulting in challenging differential diagnosis from malignant vascular neoplasms. Based on two intra-osseous EH index cases with worrisome histologic features, such as the presence of necrosis, RNA sequencing was applied for possible fusion gene discovery and potential subclassification of a novel atypical EH subset. A ZFP36-FOSB fusion was detected in one case, while a WWTR1-FOSB chimeric transcript in the other, both were further validated by FISH and RT-PCR. These abnormalities were then screened by FISH in 44 EH from different locations with 7 additional EH revealing FOSB gene rearrangements, all except one being fused to ZFP36. Interestingly, 4/6 penile EH studied showed FOSB abnormalities. Although certain atypical histologic features were observed in the FOSB-rearranged EH, including solid growth, increased cellularity, mild to moderate nuclear pleomorphism, and necrosis in 3/9 cases, no overt sarcomatous areas were discerned to objectively separate the lesions from the fusion-negative EH. No patient has developed recurrence to date, but the follow-up was relatively limited and short to draw definitive conclusions regarding behavior. Although FOSB-rearranged EH do not show significant morphologic overlap with SERPINE1-FOSB fusion-positive pseudomyogenic hemangioendothelioma, FOSB oncogenic activation is emerging as an important event in these benign and intermediate groups of vascular tumors. PMID:25043949

Antonescu, Cristina R; Chen, Hsiao-Wei; Zhang, Lei; Sung, Yun-Shao; Panicek, David; Agaram, Narasimhan P; Dickson, Brendan C; Krausz, Thomas; Fletcher, Christopher D

2014-01-01

287

Pulmonary sclerosing hemangioma: a unique epithelial neoplasm of the lung (report of 26 cases)  

PubMed Central

Background Pulmonary sclerosing hemangioma (SH) is an uncommon tumor. The aim of this study was to identify the origin of pulmonary SH and summarize its clinicopathologic features. Methods Data of 26 cases of pulmonary SH were collected and reviewed, including their clinical symptoms, chest radiological examinations, treatments, and pathological findings. Results Female patients of pulmonary SH were markedly frequent (n=23, 88.46%). Solitary mass or nodule in the lung fields was the most common manifestation (n=24, 92.31%), especially in the right middle lobe (n=9, 34.62%). There were two kinds of tumor cells: lining cells and round cells. All tumors contained a mixture of papillary, solid, sclerotic, and hemorrhagic patterns. Immunohistochemistry with a variable number of antibodies was performed for some cases. All of the detected specimens revealed strong reaction of lining cells with epithelial markers, such as thyroid transcription factor-1 (TTF-1), epithelial membrane antigen (EMA), cytokeratin (CK), pancytokeratin (PCK), and cytokeratin 7 (CK-7), while round cells were positive with TTF-1 and EMA. Until the end of last contact, none of the patients died or suffered from the recurrence of the disease after surgical treatment. Conclusions Pulmonary SH is a unique neoplasm of the lung with a characteristic solitary mass or nodule. Pulmonary epithelium might be the primary origin of the tumor cells. PMID:23587094

2013-01-01

288

Propranolol inhibits growth of hemangioma-initiating cells but does not induce apoptosis  

PubMed Central

Background Infantile hemangioma (IH) is the most common tumor of infancy. The first-line therapy for IH is propranolol, a non-selective ?-adrenergic receptor antagonist. However, mechanisms for the therapeutic effect of propranolol and regrowth of IH following cessation of treatment in some cases are not clear. We have recently shown that IH arises from multipotent stem cells. Whether IH stem cells are responsive to propranolol and are selectively targeted is unknown, and is the focus of this study. Methods IH stem cells were exposed to propranolol and assayed for cellular and molecular alterations. We used endothelial cells (ECs) as controls and bone marrow-mesenchymal progenitor cells (bm-MPCs) as normal stem/progenitor counterparts to determine selectivity. Results Our results show that propranolol significantly reduced IH stem cell growth but failed to induce caspase-3 activation. Normal bm-MPCs and mature ECs showed maintained or increased caspase-3 activation and significantly reduced cyclin-D1 levels. We further show that IH stem cells may escape apoptosis by inducing anti-apoptotic pathways. Conclusions This study reveals that propranolol does not induce apoptosis in IH stem cells, which is in contrast to ECs. Escape from apoptosis in IH stem cells may involve induction of anti-apoptotic pathways. PMID:24296797

Kum, Jina J.Y.; Khan, Zia A.

2014-01-01

289

Formation of the giant planets  

NASA Technical Reports Server (NTRS)

The observed properties of giant planets, models of their evolution and observations of protoplanetary disks provide constraints on the formation of gas giant planets. The four largest planets in our Solar System contain considerable quantities of hydrogen and helium, which could not have condensed into solid planetesimals within the protoplanetary disk. All three (transiting) extrasolar giant planets with well determined masses and radii also must contain substantial amounts of these light gases. Jupiter and Saturn are mostly hydrogen and helium, but have larger abundances of heavier elements than does the Sun. Neptune and Uranus are primarily composed of heavier elements. HD 149026 b, which is slightly more massive than is Saturn, appears to have comparable quantities of light gases and heavy elements. HD 209458 b and TrES-1 are primarily hydrogen and helium, but may contain supersolar abundances of heavy elements. Spacecraft flybys and observations of satellite orbits provide estimates of the gravitational moments of the giant planets in our Solar System, which in turn provide information on the internal distribution of matter within Jupiter, Saturn, Uranus and Neptune. Atmospheric thermal structure and heat flow measurements constrain the interior temperatures of planets. Internal processes may cause giant planets to become more compositionally differentiated or alternatively more homogeneous; high-pressure laboratory .experiments provide data useful for modeling these processes. The preponderance of evidence supports the core nucleated gas accretion model. According to this model, giant planets begin their growth by the accumulation of small solid bodies, as do terrestrial planets. However, unlike terrestrial planets, the growing giant planet cores become massive enough that they are able to accumulate substantial amounts of gas before the protoplanetary disk dissipates. The primary questions regarding the core nucleated growth model is under what conditions planets with small cores/total heavy element abundances can accrete gaseous envelopes within the lifetimes of gaseous protoplanetary disks.

Lissauer, Jack J.

2006-01-01

290

Hepatitis C: Information on Testing and Diagnosis  

MedlinePLUS

Information on Testing & Diagnosis HEPATITIS C What is Hepatitis C? Hepatitis C is a serious liver disease ... liver failure, and even liver cancer. How is Hepatitis C spread? Hepatitis C is spread when blood ...

291

Hepatitis A vaccine  

MedlinePLUS

Immunization - hepatitis A; Vaccine - HepA; Immunization - HepA ... for Disease Control and Prevention. Advisory Committee on Immunization Practices (ACIP) Recommended Immunization Schedules for Persons Aged ...

292

Hepatitis B vaccine  

MedlinePLUS

Vaccine - HepB; Immunization - hepatitis B; Immunization - HepB ... for Disease Control and Prevention. Advisory Committee on Immunization Practices (ACIP) Recommended Immunization Schedules for Persons Aged ...

293

[Analysis of blood flow in hepatic tumors by color Doppler ultrasonography].  

PubMed

We evaluated the diagnostic significance of blood flow pattern and velocity in hepatic tumors detected by color doppler ultrasonography. Fifty seven patients with hepatocellular carcinoma (HCC) and 12 patients with hepatic hemangioma (HEM) were studied with ultrasonographic apparatus equipped with color doppler system (Toshiba SSA-270A, 3.75MHz sector scanner). Furthermore 12 patients with HCC were studied repeatedly after transcatheter arterial embolization (TAE) and/or percutaneous ethanol injection (PEI). Blood flow was measurable in 2 of 12 patients with HEM (17%). Pulsatile flow with low speed (7 cm/sec) and low amplitude was detected in one patient, and continuous flow with low speed (5 cm/sec) in the other. Blood flow was measurable in 43 of 57 patients with HCC (75%). The detection rate of blood flow in HCC was significantly higher than in HEM. Pulsatile flow was detectable in 42 of 43 patients (98%). Average maximum velocity of pulsatile flow was over 40cm/sec. Analysis of blood flow after treatment provided us useful information on the effect of treatment. In conclusion, analysis of blood flow in hepatic tumors on US with color doppler system may provide useful information on differential diagnosis between HCC and HEM, the assessment of the therapeutic effect of TAE or PEI, whether additional treatment is required or not, and when it should be done if required. PMID:8145366

Oguma, M; Kawano, M; Monma, T

1994-03-01

294

Giants of the Animal Kingdom  

NSDL National Science Digital Library

The following Web sites offer a quick tour of some of the planet's outsized inhabitants, from the relatively large (e.g. giant cave cockroach) to the just plain enormous (e.g. blue whale). The first Web site (1) is an Animal Planet Feature where visitors can meet giants of the past -- such as the giant komodo dragon and the giant sloth, and some of their smaller, modern-day cousins. The site contains lots of cool graphics, including 3-D rotatable images. The next stop is a commercial Web site advertising photography expeditions let by Amos Nachoum, a professional marine and wildlife photographer. All of the expeditions listed in the left-hand column include photo galleries where visitors can view terrific photos of Argentinian orcas, polar bears, blue whales, and more (2). The following Web site (3) is the online companion to "Toothwalkers: Giants of the Arctic Ice," a PBS Nature documentary about the giant saber-toothed Arctic walrus. Visitors will find special Web features, a video clip, and links to more information on the film and its gargantuan stars. The Discovery Channel introduces the elusive giant squid in this multimedia Web feature (4). Viewers will find loads of information on this amazing creature's natural history, literary history, and much more. The site also includes a trip on a virtual submersible, where you can learn more about life 2,000 feet below sea level. The next Web site is privately hosted by Chris "Capy" Head, and provides a great overview of the world's largest rodent, the undeniably adorable capybara (5). Visitors will find basic background information, links, a photo gallery, and more. Steve Bullington presents the giant cave roach in this privately-hosted Web site (6) as part of Bullington's Pet Arthropod Page. The site includes photos and detailed background information for this outsized roach (the world's largest species). The ostrich, which can claim the title of largest living bird (with the largest eggs, as well), gets its own page in this Web feature from PBS's Nature. Readers will find a quick overview of ostrich characteristics and natural history (7). And of course, what discussion of giant animals would be complete without mentioning the blue whale? In this Web site (8), the American Cetacean Society provides an informative fact sheet on "the largest mammal, possibly the largest animal, to ever inhabit the earth.

295

Giant Magellan Telescope: overview  

NASA Astrophysics Data System (ADS)

The Giant Magellan Telescope (GMT) is a 25-meter optical/infrared extremely large telescope that is being built by an international consortium of universities and research institutions. It will be located at the Las Campanas Observatory, Chile. The GMT primary mirror consists of seven 8.4-m borosilicate honeycomb mirror segments made at the Steward Observatory Mirror Lab (SOML). Six identical off-axis segments and one on-axis segment are arranged on a single nearly-paraboloidal parent surface having an overall focal ratio of f/0.7. The fabrication, testing and verification procedures required to produce the closely-matched off-axis mirror segments were developed during the production of the first mirror. Production of the second and third off-axis segments is underway. GMT incorporates a seven-segment Gregorian adaptive secondary to implement three modes of adaptive-optics operation: natural-guide star AO, laser-tomography AO, and ground-layer AO. A wide-field corrector/ADC is available for use in seeing-limited mode over a 20-arcmin diameter field of view. Up to seven instruments can be mounted simultaneously on the telescope in a large Gregorian Instrument Rotator. Conceptual design studies were completed for six AO and seeing-limited instruments, plus a multi-object fiber feed, and a roadmap for phased deployment of the GMT instrument suite is being developed. The partner institutions have made firm commitments for approximately 45% of the funds required to build the telescope. Project Office efforts are currently focused on advancing the telescope and enclosure design in preparation for subsystem- and system-level preliminary design reviews which are scheduled to be completed in the first half of 2013.

Johns, Matt; McCarthy, Patrick; Raybould, Keith; Bouchez, Antonin; Farahani, Arash; Filgueira, Jose; Jacoby, George; Shectman, Steve; Sheehan, Michael

2012-09-01

296

Structure of giant muscle proteins.  

PubMed

Giant muscle proteins (e.g., titin, nebulin, and obscurin) play a seminal role in muscle elasticity, stretch response, and sarcomeric organization. Each giant protein consists of multiple tandem structural domains, usually arranged in a modular fashion spanning 500 kDa to 4 MDa. Although many of the domains are similar in structure, subtle differences create a unique function of each domain. Recent high and low resolution structural and dynamic studies now suggest more nuanced overall protein structures than previously realized. These findings show that atomic structure, interactions between tandem domains, and intrasarcomeric environment all influence the shape, motion, and therefore function of giant proteins. In this article we will review the current understanding of titin, obscurin, and nebulin structure, from the atomic level through the molecular level. PMID:24376425

Meyer, Logan C; Wright, Nathan T

2013-01-01

297

Structure of giant muscle proteins  

PubMed Central

Giant muscle proteins (e.g., titin, nebulin, and obscurin) play a seminal role in muscle elasticity, stretch response, and sarcomeric organization. Each giant protein consists of multiple tandem structural domains, usually arranged in a modular fashion spanning 500 kDa to 4 MDa. Although many of the domains are similar in structure, subtle differences create a unique function of each domain. Recent high and low resolution structural and dynamic studies now suggest more nuanced overall protein structures than previously realized. These findings show that atomic structure, interactions between tandem domains, and intrasarcomeric environment all influence the shape, motion, and therefore function of giant proteins. In this article we will review the current understanding of titin, obscurin, and nebulin structure, from the atomic level through the molecular level. PMID:24376425

Meyer, Logan C.; Wright, Nathan T.

2013-01-01

298

Giant lobelias exemplify convergent evolution  

PubMed Central

Giant lobeliads on tropical mountains in East Africa and Hawaii have highly unusual, giant-rosette growth forms that appear to be convergent on each other and on those of several independently evolved groups of Asteraceae and other families. A recent phylogenetic analysis by Antonelli, based on sequencing the widest selection of lobeliads to date, raises doubts about this paradigmatic example of convergent evolution. Here I address the kinds of evidence needed to test for convergent evolution and argue that the analysis by Antonelli fails on four points. Antonelli's analysis makes several important contributions to our understanding of lobeliad evolution and geographic spread, but his claim regarding convergence appears to be invalid. Giant lobeliads in Hawaii and Africa represent paradigmatic examples of convergent evolution. PMID:20074322

2010-01-01

299

Viral Hepatitis and Pregnancy  

Microsoft Academic Search

An acute hepatitis can have an onset during any trimester; it does not represent a risk for malformation in the baby, nor for the mother (with very rare exceptions). In fact, only hepatitis E virus poses a significantly increased risk to pregnant women. The most common scenario is a pregnancy in a women chronically infected with a hepatotropic virus. As

Annarosa Floreani

2009-01-01

300

Hepatitis B FAQs  

MedlinePLUS

... a few weeks, but some people can be ill for as long as 6 months. Can a person spread Hepatitis B without having symptoms? Yes. Many people with Hepatitis B have no symptoms, but these people can still spread the virus. What are the symptoms of ...

301

Hepatitis A FAQs  

MedlinePLUS

... poor sanitary conditions or poor personal hygiene. The food and drinks most likely to be contaminated are fruits, vegetables, shellfish, ice, and water. In the United States, chlorination of water kills Hepatitis A virus that enters the water supply. Who is at risk for Hepatitis A? Although ...

302

Intestinal obstruction caused by infarcted splenic hemangioma with renal vein thrombosis in a newborn: a case report.  

PubMed

The spleen in newborns, infants, and children is rarely involved in a variety of pathological processes. These processes may involve an isolated splenic disease or may be a part of a systemic illness. Renal vein thrombosis in infants of diabetic mothers has been reported. We report a case of a newborn with intestinal obstruction caused by an infarcted splenic hemangioma and renal vein thrombosis. To the best of our knowledge, this is the youngest case with both above-mentioned diagnoses and causes of intestinal obstruction in the English medical literature. PMID:12403090

Lee, Chien-Hsing

2002-01-01

303

Giant axonal neuropathy: MRS findings.  

PubMed

Giant axonal neuropathy (GAN) is a rare genetic disease of childhood involving the central and peripheral nervous systems. Axonal loss with several giant axons filled with neurofilaments is the main histopathological feature of peripheral nerve biopsies in this disease. Routine neuroimaging studies reveal diffuse hyperintensities in cerebral and cerebellar white matter. In this case report, the authors present the brain magnetic resonance spectroscopic features (normal N-acetylaspartate/creatine and increased choline/creatine and myoinositol/creatine ratios), which might indicate the absence of neuroaxonal loss and the presence of significant demyelination and glial proliferation in white matter, of an 11-year-old boy diagnosed with GAN. PMID:14569833

Alkan, Alpay; Kutlu, Ramazan; Sigirci, Ahmet; Baysal, Tamer; Altinok, Tayfun; Yakinci, Cengiz

2003-10-01

304

Crab Giant Pulses & Other Dispersed Transients  

E-print Network

Crab Giant Pulses & Other Dispersed Transients Steve Ellingson (Virginia Tech) on behalf of the LWA ~ 09:00 local time, weekday meansubtraction #12;· Known: Pulsars ­ Crab Giant Pulses (CGPs) (Popov et low duty cycleEllingson, Liu & Craig (2011), LWA Memo 176. #12;First Glimpses of Crab Giant Pulses

Ellingson, Steven W.

305

Excitation of giant dipole and giant quadrupole states in nuclei  

Microsoft Academic Search

Calculations are presented for the excitation by protons of giant dipole (T = 1) and quadrupole (T = 0) states in nuclei. Two simple models are used for the transition densities and potentials in the dipole excitation. The usual deformed optical potential is applied to the quadrupole transitions. The strengths are determined by exhausting the linear energy-weighted sum rules. The

G. R. Satchler

1972-01-01

306

ZFP36-FOSB fusion defines a subset of epithelioid hemangioma with atypical features.  

PubMed

Epithelioid hemangioma (EH) is a benign neoplasm with distinctive vasoformative features, which occasionally shows increased cellularity, cytologic atypia, and/or loco-regional aggressive growth, resulting in challenging differential diagnosis from malignant vascular neoplasms. Based on two intraosseous EH index cases with worrisome histologic features, such as the presence of necrosis, RNA sequencing was applied for possible fusion gene discovery and potential subclassification of a novel atypical EH subset. A ZFP36-FOSB fusion was detected in one case, while a WWTR1-FOSB chimeric transcript in the other, both were further validated by fluorescence in situ hybridization (FISH) and reverse transcription polymerase chain reaction (RT-PCR). These abnormalities were then screened by FISH in 44 EH from different locations with seven additional EH revealing FOSB gene rearrangements, all except one being fused to ZFP36. Interestingly, 4/6 penile EH studied showed FOSB abnormalities. Although certain atypical histologic features were observed in the FOSB-rearranged EH, including solid growth, increased cellularity, mild to moderate nuclear pleomorphism, and necrosis in 3/9 cases, no overt sarcomatous areas were discerned to objectively separate the lesions from the fusion-negative EH. No patient has developed recurrence to date, but the follow-up was relatively limited and short to draw definitive conclusions regarding behavior. Although FOSB-rearranged EH do not show significant morphologic overlap with SERPINE1-FOSB fusion-positive pseudomyogenic hemangioendothelioma, FOSB oncogenic activation is emerging as an important event in these benign and intermediate groups of vascular tumors. PMID:25043949

Antonescu, Cristina R; Chen, Hsiao-Wei; Zhang, Lei; Sung, Yun-Shao; Panicek, David; Agaram, Narasimhan P; Dickson, Brendan C; Krausz, Thomas; Fletcher, Christopher D

2014-11-01

307

Knockdown of VEGFR2 Inhibits Proliferation and Induces Apoptosis in Hemangioma-Derived Endothelial Cells  

PubMed Central

Angiogenesis is a process of development and growth of new capillary blood vessels from pre-existing vessels. Angiogenic growth factors play important roles in the development and maintenance of some malignancies, of which vascular endothelial growth factor (VEGF)/VEGFR2 interactions are involved in proliferation, migration, and survival of many cancer cells. The aim of this study was to investigate the function of VEGFR2 in human hemangiomas (HAs). Using immunohistochemistry assay, we examined the expression levels of VEGF, VEGFR2, Ki-67, glucose transporter-1 (Glut-1), phosphorylated protein kinase B (p-AKT) and p-ERK in different phases of human HAs. Positive expression of VEGF, VEGFR2, Ki-67, Glut-1, p-AKT and p-ERK was significantly increased in proliferating phase HAs, while decreased in involuting phase HAs (P=0.001; P=0.003). In contrast, cell apoptotic indexes were decreased in proliferating phase HAs, but increased in involuting phase HAs (P<0.01). Furthermore, we used small hairpin RNA (shRNA)-mediated VEGFR2 knockdown in primary HA-derived endothelial cells (HemECs) to understand the role of VEGF/VEGFR2 signaling. Knockdown of VEGFR2 by Lv-shVEGFR2 inhibited cell viability and induced apoptosis in primary HemECs companied with decreased expression of p-AKT, p-ERK, p-p38MAPK and Ki-67 and increased expression of caspase-3 (CAS-3); Overexpression of VEGFR2 promoted cell viability and blocked apoptosis in Lv-VEGFR2-transfected HemECs. Taken together, our findings demonstrate that, increased expression of VEGFR2 is involved in the development of primary HemECs possibly through regulation of the AKT and ERK pathways, suggesting that VEGFR2 may be a potential therapeutic target for HAs. PMID:24704994

Ou, J.M.; Yu, Z.Y.; Qiu, M.K.; Dai, Y.X.; Dong, Q.; Shen, J.; Dong, P.; Wang, X.F.; Liu, Y.B.; Quan, Z.W.; Fei, Z.W.

2014-01-01

308

Pulmonary sclerosing hemangioma presenting with dense spindle stroma cells: a potential diagnostic pitfall  

PubMed Central

Pulmonary sclerosing hemangioma (PSH) is an uncommon pulmonary tumor. Histologically, PSH typically consists of two types of cells, surface cuboidal cells and polygonal cells, four architectural patterns including papillary, sclerotic, solid, and hemorrhagic. Herein, we present a case of PSH in a 59-year-old Chinese female. The tumor was predominantly composed of solid area presenting with diffuse spindle cells rather than polygonal cells. Focally, classical papillary and sclerotic area could be seen. Immunohistochemical staining showed that the spindle cells were positive for TTF-1, EMA, Actin(SM) and Vimentin, and negative for cytokeratin, cytokeratin7, cytokeratin5/6, surfactant apoprotein A, surfactant apoprotein B, CD34, CD99, S-100, HMB45, Desmin, Synaptophysin, CD56, ALK and Calretinin. The immunophenotype of the dense spindle cells in this case was similar to that of the polygonal cells, and thus the spindle cells may be the variants of polygonal cells. Based on morphologic features and the immunohistochemical profile, the tumor was diagnosed as a PSH. The significance of spindle cells change is unclear for us. To our knowledge, this is the first reported case of PSH showing dense spindle cells in solid area. This case represents a potential diagnostic pitfall, as it may be misdiagnosed as a mesenchymal tumor such as inflammatory myofibroblastic tumor, synovial sarcoma, solitary fibrous tumor, leiomyoma, or even mesothelioma, especially if the specimen is limited or from fine- needle aspiration. Virtual slides The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1235401622806126 PMID:23227905

2012-01-01

309

Cavernous hemangioma of the third ventricle: a case report and review of the literature  

PubMed Central

Background Although cavernous hemangiomas (CHs) can be found anywhere in the central nervous system, CHs of the third ventricle have been reported in only 29 patients (including our case). In the current case report, we discuss the clinical characteristics and surgical outcome of CHs of the third ventricle. Case presentation A 64-year-old female was admitted to our emergency room with a sudden decreased level of consciousness. Brain imaging studies demonstrated a multi-lobulated hemorrhagic mass in the third ventricle. The lesion was removed via the transcallosal-interforniceal approach and pathologically diagnosed as CH. Postoperatively, the patient had a transient neurological deficit due to hypothalamic injury and recovered to the normal status at 2 months after the operation. In the review of 29 cases, the mean age of the patients was 40 years with a slight female preponderance (female/male, 17/12). The majority of the patients complained of a mass effect with signs of increased intracranial pressure; only one case was asymptomatic. Gross total resection was achieved in 81% of the cases. Around 80% of the patients were asymptomatic or improved from the initial symptoms. Mortality rate was 6.9% and the most common complication was hydrocephalus. Conclusions As demonstrated in the review of the previous reports, the outcome is favorable after surgical excision for CH of the third ventricle. Hence, surgical excision appears to be the treatment of choice for CH located in the third ventricle, which tends to grow rapidly resulting in a mass effect. PMID:25069472

2014-01-01

310

[Treatment of viral hepatitis].  

PubMed

Chronic forms of viral B,C and D hepatitis and fulminant hepatitis represent a serious healthcare problem. The study deals with the changes in the strategy in treating these diseases. During the chronic active hepatitis caused by the B hepatitis virus, the main aim of treatment is to cease multiplication of viruses, eliminate the clinical symptoms, prevent the development of cirrhosis, or the origin of hepatocellular carcinoma. The authors analyze the possibilities of the application of corticosteroids, viricidal drugs (vidarabin and interferons) and other medicaments (acyclovir, zidovudin, duramin, gancyclovir, chinacrin, and others) besides corticosteroids, interleukin 2 and tymozin from the group of immunomodulators were tested. The testing included the factor stimulating the colonies of granulocytes and myeloblasts and other substances. The therapy of acute protracted B hepatitis by means of interferon still requires controlled studies. Superinfection by D virus in chronic carriers of HBsAG causes chronic hepatitis which quickly leads to the development of cirrhosis. The therapy on basis of alpha interferon decreases the RNA virus D hepatitis serum level and leads to an improvement in the development of chronic hepatitis in half of the patients. Therapy of chronic C hepatitis on basis of corticosteroids is ineffective, and can be dangerous. Acyclovir is proved to be ineffective as well. The open study indicated certain positive results in application of interferon. The fulminant hepatitis can be defined as a development of encephalopathy and a decrease of the prothrombin time to less than 50% in the course of acute hepatitis. The break-point in the therapy of fulminant hepatitis took place in association with the performance of the transplantation of the liver. Impossibility to transplant the liver means that the effect of therapy of fulminant hepatitis is merely of supportive value. Majority of patients die due to neurologic complications, namely unmanageable oedema of the brain. But still, neither the antioedema therapy, e.g. on basis of manitol, as well as by means of corticosteroids, hemodialysis, hemofiltration, plasmapheresis and hemoperfusion, nor the treatment on basis of E1 prostaglandine improved the survival of patients. (Tab. 2, Ref. 82). PMID:8556359

Miguet, J; Hrusovský, S

1995-09-01

311

Giant Lipoma: A Case Report  

PubMed Central

A lipoma is a fatty tissue tumor presenting as a painless slowly growing mass that can affect any part of the body rich in adipose tissue. Lipomas can be present in the thigh, shoulder, trunk, etc, although they are usually small. We are reporting a 65-year-old man with a giant lipoma involving his left buttock and lumbar region. PMID:23610489

Zaroo, Mohammad Inam; Bashir, Sheikh Adil; Mohsin, Mir; Baba, Peerzada Umar Farooq; Farooq, Syed Suraiya Arjumand; Zargar, Haroon Rashid

2011-01-01

312

Gravitational scattering by giant planets  

E-print Network

We seek to characterize giant-planet systems by their gravitational scattering properties. We do this to a given system by integrating it numerically along with a large number of hypothetical small bodies that are initially in eccentric habitable zone (HZ)-crossing orbits. Our analysis produces a single number, the escape rate, which represents the rate at which the small-body flux is perturbed away by the giant planets into orbits that no longer pose a threat to terrestrial planets inside the HZ. Obtaining the escape rate this way is similar to computing the largest Liapunov exponent as the exponential rate of divergence of two nearby orbits. For a terrestrial planet inside the HZ, the escape rate value quantifies the "protective" effect that the studied giant-planet system offers. Therefore, escape rates could provide information on whether certain giant-planet configurations produce a more desirable environment for life than the others. We present some computed escape rates on selected planetary systems, f...

Laakso, Teemu; Kaasalainen, Mikko

2014-01-01

313

Vibration modes of giant gravitons  

Microsoft Academic Search

We examine the spectrum of small vibrations of giant gravitons when the gravitons expand in anti--de Sitter space and when they expand on the sphere. For any given angular harmonic, the modes are found to have frequencies related to the curvature length scale of the background; these frequencies are independent of radius (and hence angular momentum) of the brane itself.

Sumit R. Das; Antal Jevicki; Samir D. Mathur

2001-01-01

314

Giant resonances in O-16  

E-print Network

Giant resonances in O-16 have been studied with inelastic scattering of 240 MeV alpha particles at small angles, Isoscalar E0, E1, and E2 strength corresponding to 48 +/- 10%, 32 +/- 7%, and 53 +/- 10%, of the respective energy-weighted sum rule...

Lui, YW; Clark, HL; Youngblood, David H.

2001-01-01

315

Formation of the Giant Planets  

Microsoft Academic Search

The structure of a gaseous envelope surrounding a protoplanet has been investigated in connection with the formation of the giant planets. Under the assumptions of spherical symmetry and hydrostatic equilibrium, the structure has been calculated for the regions of Jupiter, Saturn, Uranus and Neptune. Energy transfer in the envelope has been taken into account precisely. When the core mass increases

Hiroshi Mizuno

1980-01-01

316

[Prevention of viral hepatitis].  

PubMed

Prevention of viral hepatitis infection involves health measures designed to avert transmission of viral agents and promote the use of gammaglobulin and vaccines. The availability of safe drinking water and improvements in quality of life result in better individual hygiene; these factors have had the greatest impact on hepatitis A prevention. Serum gammaglobulin administration has been replaced by vaccinations for pre-exposure, and to a great extent for post-exposure prophylaxis because of the progressively lower anti-HAV content of gammaglobulin and the short duration of the protective effect. Universal vaccination in childhood is the recommended measure for controlling hepatitis A. Adults belonging to high-risk groups should also undergo vaccination. The incidence of hepatitis B has decreased worldwide because of universal vaccination programs, initiated in preadolescence and childhood. Prevention of hepatitis C requires control of situations in which there is a likelihood of parenteral infection with the virus. Post-transfusion hepatitis has been virtually eradicated, but considerable effort is still needed to prevent nosocomial hepatitis. PMID:17194391

Bruguera, Miguel

2006-12-01

317

Nursery of Giants  

NASA Technical Reports Server (NTRS)

Hidden behind a shroud of dust in the constellation Cygnus is a stellar nursery called DR21, which is giving birth to some of the most massive stars in our galaxy. Visible light images reveal no trace of this interstellar cauldron because of heavy dust obscuration. In fact, visible light is attenuated in DR21 by a factor of more than 10,000,000,000,000,000,000,000,000,000,000,000,000,000 (ten thousand trillion heptillion).

New images from NASA's Spitzer Space Telescope allow us to peek behind the cosmic veil and pinpoint one of the most massive natal stars yet seen in our Milky Way galaxy. The never-before-seen star is 100,000 times as bright as the Sun. Also revealed for the first time is a powerful outflow of hot gas emanating from this star and bursting through a giant molecular cloud.

This image is a large-scale mosaic assembled from individual photographs obtained with the InfraRed Array Camera (IRAC) aboard Spitzer. The image covers an area about two times that of a full moon. The mosaic is a composite of images obtained at mid-infrared wavelengths of 3.6 microns (blue), 4.5 microns (green), 5.8 microns (orange) and 8 microns (red). The brightest infrared cloud near the top center corresponds to DR21, which presumably contains a cluster of newly forming stars at a distance of 10,000 light-years.

Protruding out from DR21 toward the bottom left of the image is a gaseous outflow (green), containing both carbon monoxide and molecular hydrogen. Data from the Spitzer spectrograph, which breaks light into its constituent individual wavelengths, indicate the presence of hot steam formed as the outflow heats the surrounding molecular gas. Outflows are physical signatures of processes that create supersonic beams, or jets, of gas. They are usually accompanied by discs of material around the new star, which likely contain the materials from which future planetary systems are formed. Additional newborn stars, depicted in green, can be seen surrounding the DR21 region.

The red filaments stretching across this image denote the presence of polycyclic aromatic hydrocarbons. These organic molecules, comprised of carbon and hydrogen, are excited by surrounding interstellar radiation and become luminescent at wavelengths near 8.0 microns. The complex pattern of filaments is caused by an intricate combination of radiation pressure, gravity and magnetic fields. The result is a tapestry in which winds, outflows and turbulence move and shape the interstellar medium.

To the lower left of the mosaic is a large bubble of gas and dust, which may represent the remnants of a past generation of stars.

2004-01-01

318

Feature Hepatitis: The Dangers of Hepatitis: What you should know from A to E  

MedlinePLUS

... Navigation Bar Home Current Issue Past Issues Feature Hepatitis The Dangers of Hepatitis: What you should know from A to E ... drugs. In some cases, hepatitis lasts a lifetime. Hepatitis: Acute or Chronic? Acute hepatitis is the initial ...

319

Gene expression analysis reveals marked differences in the transcriptome of infantile hemangioma endothelial cells compared to normal dermal microvascular endothelial cells  

PubMed Central

Background Infantile hemangiomas are benign vascular tumors primarily found on the skin in 10% of the pediatric population. The etiology of this disease is largely unknown and while large scale genomic studies have examined the transcriptomes of infantile hemangioma tumors as a whole, no study to date has compared the global gene expression profiles of pure infantile hemangioma endothelial cells (HEMECs) to that of normal human dermal microvascular endothelial cells (HDMVECs). Methods To shed light on the molecular differences between these normal and aberrant dermal endothelial cell types, we performed whole genome microarray analysis on purified cultures of HEMECs and HDMVECs. We then utilized qPCR and immunohistochemistry to confirm our microarray results. Results Our array analysis identified 125 genes whose expression was upregulated and 104 genes whose expression was downregulated by greater than two fold in HEMECs compared to HDMVECs. Bioinformatics analysis revealed three major classifications of gene functions that were altered in HEMECs including cell adhesion, cell cycle, and arachidonic acid production. Several of these genes have been reported to be critical regulators and/or mutated in cancer, vascular tumors, and vascular malformations. We confirmed the expression of a subset of these differentially expressed genes (ANGPT2, ANTXR1, SMARCE1, RGS5, CTAG2, LTBP2, CLDN11, and KISS1) using qPCR and utilized immunohistochemistry on a panel of paraffin embedded infantile hemangioma tumor tissues to demonstrate that the cancer/testis antigen CTAG2 is highly abundant in vessel-dense proliferating infantile hemangiomas and with significantly reduced levels during tumor involution as vascular density decreases. Conclusion Our data reveal that the transcriptome of HEMECs is reflective of a pro-proliferative cell type with altered adhesive characteristics. Moveover, HEMECs show altered expression of many genes that are important in the progression and prognosis of metastatic cancers. PMID:23531100

2013-01-01

320

Aggressive hepatitis (image)  

MedlinePLUS

Chronic active hepatitis is a liver disease caused by infection, drug ingestion, metabolic or autoimmune disorders. Necrosis (death) of liver cells, inflammation and fibrosis may lead to liver failure. Death within 5 years ...

321

Living with Hepatitis B  

MedlinePLUS

... the virus on to others. 3. Hepatitis B Core Antibody (HBcAb or anti-HBc): This antibody does ... health care provider recommend medications that are not harmful to the liver. This includes both over-the- ...

322

Hepatitis C Test  

MedlinePLUS

... sample drawn from a vein in your arm Test Preparation Needed? None The Test Sample What is being tested? Hepatitis C (HCV) ... a blood sample and throat culture. Is any test preparation needed to ensure the quality of the ...

323

What Is Hepatitis?  

MedlinePLUS

... Français ??????? Español RSS Feed Youtube Twitter Facebook Google + iTunes What is hepatitis? Online Q&A Updated ... are not widely available. Share Email Twitter Facebook Google Delicious LinkedIn More... Print Question and answer archives ...

324

Alcohol and Hepatitis C  

MedlinePLUS

... code here Enter ZIP code here Daily Living: Alcohol for Veterans and the Public Alcohol and Hepatitis: Entire Lesson Overview Alcohol is one ... related to choices you make about your lifestyle . Alcohol and fibrosis Fibrosis is the medical term for ...

325

Travelers' Health: Hepatitis E  

MedlinePLUS

... by hepatitis E virus (HEV), a single-stranded, RNA virus belonging to the Hepeviridae family. TRANSMISSION HEV ... HEV IgM and IgG in serum. Detecting HEV RNA in serum or stools further confirms the serologic ...

326

Travelers' Health: Hepatitis A  

MedlinePLUS

... INFECTIOUS AGENT Hepatitis A virus (HAV) is an RNA virus classified as a picornavirus. TRANSMISSION Through direct ... months after infection. EPIDEMIOLOGY Common throughout the developing world, where infections most frequently are acquired during early ...

327

Guiding the Giant  

NASA Astrophysics Data System (ADS)

New ESO Survey Provides Targets for the VLT Giant astronomical telescopes like the ESO Very Large Telescope (VLT) must be used efficiently. Observing time is expensive and there are long waiting lines of excellent research programmes. Thus the work at the telescope must be very well prepared and optimized as much as possible - mistakes should be avoided and no time lost! Astronomers working with the new 8-m class optical/infrared telescopes must base their observations on detailed lists of suitable target objects if they want to perform cutting-edge science. This is particularly true for research programmes that depend on observations of large samples of comparatively rare, distant objects. This type of work requires that extensive catalogues of such objects must be prepared in advance. One such major catalogue - that will serve as a very useful basis for future VLT observations - has just become available from the new ESO Imaging Survey (EIS). The Need for Sky Surveys Astronomers have since long recognized the need to carry out preparatory observations with other telescopes in order to "guide" large telescopes. To this end, surveys of smaller or larger parts of the sky have been performed by wide-field telescopes, paving the way for subsequent work at the limits of the largest available ground-based telescopes. For instance, a complete photographic survey of the sourthern sky (declination < -17.5°) was carried out in the 1970's with the ESO 1-metre Schmidt Telescope in support of the work at the 3.6-m telescope at the ESO La Silla observatory. However, while until recently most observational programmes could rely on samples of objects found on photographic plates, this is no longer possible. New image surveys must match the fainter limiting magnitudes reached by the new and larger telescopes. Modern digital, multi-colour, deep imaging surveys have thus become an indispensable complement to the 8-m telescopes. The new generation of imaging surveys will, without doubt, be the backbone of future research and are likely to be as long-lived as their earlier counterparts, which have served the astronomical community so well over the past decades. The new surveys are now becoming possible, thanks to the new, extremely light-sensitive CCD-mosaics mounted on wide-field telescopes. The ESO Imaging Survey (EIS) A very successful, major step in this direction has recently been taken at ESO. It concerns an imaging survey with the 3.5-m New Technology Telescope (NTT) at La Silla, aimed at defining targets for the first year of operation of the VLT. In addition to serving the future observers, this survey is also public , i.e., the resulting data are made available to all interested parties. The project is known as the ESO Imaging Survey (EIS). It is supervised by a Working Group with members from the European astronomical community ( [1]) that has been responsible for defining the survey strategy and for monitoring the progress. It has been a major challenge to carry out such a public survey in the very short time available. The work by the EIS Team has involved the survey observations at the NTT, development of a pipeline to process the raw data, advanced data reduction, identification of large samples of astronomically "interesting" targets and, not least, the distribution of images and other survey products before the start of operation of the VLT. To cope with the ambitious one-year timetable, a novel type of collaboration between ESO and the astronomical communities in the ESO Member States was set up. It has allowed to combine efficiently the scientific and technical expertise of the community with ESO in-house know-how and infrastructure. This model has been very successful and may well set the example for future surveys. Science Goals of EIS EIS is in many aspects a novel approach for large-scale, ground-based optical observations, in support of large-telescope science. The speed with which raw EIS data have been converted to deliverable products is quite unprecedented, given the nature and scope of t

1998-08-01

328

Children with hepatitis C  

Microsoft Academic Search

Hepatitis C affects thousands of children throughout the world. Most children acquire the virus through vertical transmission,\\u000a although parenteral routes of acquisition are also common. Hepatitis C progresses slowly, with mild biopsy findings and no\\u000a symptoms in most children and in many adults. However, significant liver inflammation and fibrosis can occur in childhood.\\u000a Trials of antiviral therapy with interferon and

Girish Subba Rao; Jean Pappas Molleston

2005-01-01

329

Hepatitis b vaccination  

Microsoft Academic Search

Hepatitis B virus (HBV)infection is a major cause of chronic hepatitis and cirrhosis,with an estimated 350 million people\\u000a worldwide infected with the virus.Despite continuing advances in antiviral therapy,a cure for chronic HBV infection is considered\\u000a an elusive goal.Thus,primary prevention by immunization with HBV vaccines remains the most effective means to control the\\u000a transmission of HBV infection.

Albert D. Min; Aaron Walfish; Henry C. Bodenheimer

2006-01-01

330

Mechanisms of Hepatic Fibrogenesis  

PubMed Central

Substantial improvements in the treatment of chronic liver disease have accelerated interest in uncovering the mechanisms underlying hepatic fibrosis and its resolution. Activation of resident hepatic stellate cells into proliferative, contractile, and fibrogenic cells in liver injury remains a dominant theme driving the field. However, several new areas of rapid progress in the past 5–10 years also have taken root, including: (1) identification of different fibrogenic populations apart from resident stellate cells, for example, portal fibroblasts, fibrocytes, and bone-marrow– derived cells, as well as cells derived from epithelial mesenchymal transition; (2) emergence of stellate cells as finely regulated determinants of hepatic inflammation and immunity; (3) elucidation of multiple pathways controlling gene expression during stellate cell activation including transcriptional, post-transcriptional, and epigenetic mechanisms; (4) recognition of disease-specific pathways of fibrogenesis; (5) re-emergence of hepatic macrophages as determinants of matrix degradation in fibrosis resolution and the importance of matrix cross-linking and scar maturation in determining reversibility; and (6) hints that hepatic stellate cells may contribute to hepatic stem cell behavior, cancer, and regeneration. Clinical and translational implications of these advances have become clear, and have begun to impact significantly on the management and outlook of patients with chronic liver disease. PMID:18471545

Friedman, Scott L.

2010-01-01

331

All Kids Need Hepatitis B Shots  

MedlinePLUS

... immunize.org action coalition I All kids need hepatitis B shots! A series of shots can prevent ... got infected with hepatitis B virus What is hepatitis B? How do children and teens get hepatitis ...

332

VACCINE INFORMATION STATEMENT Hepatitis B Vaccine  

E-print Network

VACCINE INFORMATION STATEMENT Hepatitis B Vaccine What You Need to Know ManyVaccine; - beingstuckwithausedneedle. 2 Hepatitis B vaccine: Why get vaccinated? Hepatitis hepatitis B vaccine and when? Children and Adolescents · Babiesnormallyget3dosesofhepatitisBvaccine: 1st

Tennessee, University of

333

Giant diamagnetism of gold nanorods  

NASA Astrophysics Data System (ADS)

The presence of giant diamagnetism in Au nanorods, NRs, is shown to be a possible consequence of field induced currents in the surface electrons. The distance, ?, between quantum surface energy levels has been calculated as a function of the NRs radius. Note that those electrons occupying states for which ? > k B T are steadily orbiting with constant orbital moment. The diamagnetic response induced when a field is turned on remains constant during the time the field is acting. As the NRs radius increases, ? decreases and accordingly the electron fraction available to generate constant currents decreases, consequently the surface diamagnetic susceptibility decreases towards its bulk value. The surface electronic motion induced by the axial applied field on electrons confined into a cylindrical surface accounts with extremely good quantitative agreement for the giant diamagnetism recently measured and reported.

Hernando, A.; Ayuela, A.; Crespo, P.; Echenique, P. M.

2014-07-01

334

A Giant Peritoneal Loose Body  

PubMed Central

Peritoneal loose bodies (PLBs) are usually discovered incidentally during laparotomy or autopsy. A few cases of giant PLBs presenting with various symptoms have been reported in the literature. Here, we describe a case of a giant PLB incidentally found in the pelvic cavity of a 50-year-old man. Computed tomography revealed a free ovoid mass in the pelvic cavity that consisted of central dense, heterogeneous calcifications and peripheral soft tissue. The mass was an egg-shaped, hard, glistening concretion measuring 7.5×7.0×6.8 cm and weighing 160 g. This concretion consisted of central necrotic fatty tissue surrounded by concentrically laminated, acellular, fibrous material. Small PLBs usually do not require any specific treatment. However, if PLBs cause alimentary or urinary symptoms due to their large size, surgical removal may be recommended. It is essential for clinicians to be aware of this entity and its characteristic features to establish the correct diagnosis. PMID:24009634

Kim, Hyun-Soo; Sung, Ji-Youn; Park, Won Seo

2013-01-01

335

Obscurin: a multitasking muscle giant  

Microsoft Academic Search

Obscurin (~800 kDa) is the third member of a family of giant proteins expressed in vertebrate striated muscle, along with titin (3–3.7 MDa) and nebulin (~800 kDa). Like its predecessors, it is a multidomain protein composed of tandem adhesion modules and signaling domains. Unlike titin and nebulin, which are integral components of sarcomeres, obscurin is concentrated at the peripheries of Z-disks and M-lines,

Aikaterini Kontrogianni-Konstantopoulos; Robert J. Bloch

2005-01-01

336

[Giant ameloblastoma of the jaw].  

PubMed

Ameloblastomas represent benign, epithelial alveolar tumors, which originate from epithelial enamel cells (ameloblasts). Due to their locally aggressive character, they may develop pathological significance. Radical surgery remains the therapy of choice. As demonstrated by the case of a 71-year-old patient with giant ameloblastoma of the upper jaw, early resection is recommended. The high propensity for recurrence demands long-term post-operative follow-up, since late recidive tumours may also occur. PMID:19727626

Wysluch, A; Hölzle, F; Maurer, P

2009-11-01

337

Thermionic emission from giant fullerenes  

Microsoft Academic Search

Large even-numbered carbon clusters in the size range from 100 to 600 atoms (giant fullerenes) were generated by laser vaporization and directly injected as positive ions via a supersonic beam into the magnetic trap of an ion cyclotron resonance apparatus. Intense laser excitation of the magnetically levitated fullerenes at 4.0 eV was found to result in production of multiply charged

S. Maruyama; M. Y. Lee; R. E. Haufler; Y. Chai; R. E. Smalley

1991-01-01

338

Damping of multiphonon giant resonances  

NASA Astrophysics Data System (ADS)

The phonon damping model (PDM) is applied to derive the equations that describe the damping of three-, and n -phonon giant resonances. As examples of the application of this approach, the results of numerical calculations for the double giant resonance (DGDR) ( n=2) and triple giant dipole resonance (TGDR) ( n=3) in 90 Zr, 120 Sn and 208 Pb are discussed and compared with those obtained by folding independent giant dipole resonances (GDRs) (the folding results). For the DGDR in the double magic nucleus 208 Pb, we found that these results are very close to the folding results. In the open-shell nuclei 90 Zr and 120 Sn, a clear deviation from the folding results is observed in calculations in agreement with the experimental trend. The results for the integrated strength and energy of TGDR are found to be much closer to the folding results in all three nuclei. The TGDR widths in the open shell nuclei are found to be larger than the folding results. We also show that the relationship S1(2)=4 S1(1)S0(1) , which connects the energy-weighted sum (EWS) S1(2) of the DGDR strengths to the EWS S1(1) and the non-energy-weighted sum of strengths (NEWS) S1(1) of GDR, does not hold in any approximation in which the energy of the two-phonon state is deviated from the sum of energies of the two one-phonon states due to anharmonicity. A small deviation of the two-phonon energy is enough to cause a noticeable change in the DGDR strength compared to the independent-phonon picture. A new sum rule relationship is derived within the PDM.

Dinh Dang, Nguyen; Tanabe, Kosai; Arima, Akito

2000-08-01

339

Giant gravitons from holomorphic surfaces  

Microsoft Academic Search

We introduce a class of supersymmetric cycles in spacetimes of the form AdS times a sphere or T1,1 which can be considered as generalizations of the giant gravitons. Branes wrapped on these cycles preserve 1\\/2, 1\\/4 or 1\\/8 of the supersymmetry. On the CFT side these configurations correspond to superpositions of the large number of BPS states.

Andrei Mikhailov

2000-01-01

340

A Giant Juvenile Nasopharyngeal Angiofibroma  

PubMed Central

Juvenile nasopharyngeal angiofibroma (JNA) are locally growing highly vascular tumours. They are treated primarily by surgical excision ranging from open approach to endoscopic approach. We presented a 20-year-old male with a giant nasopharyngeal juvenile angiofibroma obliterating the pterygopalatine fossa bilaterally, invasing the sphenoid bone and extending to the left nasal passage. His complaints were epistaxis and nasal obstruction. After embolization, the patient was treated surgically with endoscopic approach and discharged as cured without any complication. PMID:23714961

Yuce, Salim; Uysal, Ismail Onder; Dogan, Mansur; Polat, Kerem; Salk, Ismail; Muderris, Suphi

2012-01-01

341

Observed Properties of Giant Cells  

NASA Technical Reports Server (NTRS)

The existence of Giant Cells has been suggested by both theory and observation for over 45 years. We have tracked the motions of supergranules in SDO/HMI Doppler velocity data and find larger (Giant Cell) flows that persist for months. The flows in these cells are clockwise around centers of divergence in the north and counter-clockwise in the south. Equatorward flows are correlated with prograde flows - giving the transport of angular momentum toward the equator that is needed to maintain the Sun's rapid equatorial rotation. The cells are most pronounced at mid- and high-latitudes where they exhibit the rotation rates representative of those latitudes. These are clearly large, long-lived, cellular features, with the dynamical characteristics expected from the effects of the Sun's rotation, but the shapes of the cells are not well represented in numerical models. While the Giant Cell flow velocities are small (<10 m/s), their long lifetimes should nonetheless substantially impact the transport of magnetic flux in the Sun's near surface layers.

Hathaway, David H.; Upton, Lisa; Colegrove, Owen

2014-01-01

342

Observed properties of Giant Cells  

NASA Astrophysics Data System (ADS)

The existence of Giant Cells has been suggested by both theory and observation for over 45 years. We have tracked the motions of supergranules in SDO/HMI Doppler velocity data and find larger (Giant Cell) flows that persist for months. The flows in these cells are clockwise around centers of divergence in the north and counter-clockwise in the south. Equatorward flows are correlated with prograde flows - giving the transport of angular momentum toward the equator that is needed to maintain the Sun’s rapid equatorial rotation. The cells are most pronounced at mid- and high-latitudes where they exhibit the rotation rates representative of those latitudes. These are clearly large, long-lived, cellular features, with the dynamical characteristics expected from the effects of the Sun’s rotation, but the shapes of the cells are not well represented in numerical models. While the Giant Cell flow velocities are small (<10 m/s), their long lifetimes should nonetheless substantially impact the transport of magnetic flux in the Sun’s near surface layers.

Hathaway, David H.; Upton, Lisa; Colegrove, Owen

2014-06-01

343

Young Brown Dwarfs & Giant Planets:Young Brown Dwarfs & Giant Planets: Recent Observations and ModelRecent Observations and Model  

E-print Network

Young Brown Dwarfs & Giant Planets:Young Brown Dwarfs & Giant Planets: Recent Observations to the modelsRecent revision to the models #12;Brown Dwarf (BD) and Giant PlanetsBrown Dwarf (BD) and Giant Planets (GP) definitions(GP) definitions Brown Dwarfs and Giant Plants fall into the category of sub

344

Lithospheric footprints of giant orogenic gold systems  

Microsoft Academic Search

Small orogenic gold deposits have the same deposit-scale geological and geochemical features as those that characterise giant orogenic gold systems (>16 Moz Au). Therefore, a broader-scale approach is needed to identify the critical controls on giant deposits and their disproportionate distribution throughout time and space. Ages of giant gold systems cluster around well-defined periods of lithospheric growth at continental margins,

F. P. Bierlein; D. I. Groves; R. J. Goldfarb; A. B. Christie

345

Cabergoline Treatment in Invasive Giant Prolactinoma  

PubMed Central

Patients with invasive giant prolactinoma suffer from a constellation of symptoms including headache, blurred vision, lethargy, and sexual dysfunction. Cabergoline, a potent dopamine agonist, is a known medication prescribed for the treatment of invasive giant prolactinoma. Here, we report a case of invasive giant prolactinoma in a 52-year-old Saudi male with dramatic response to cabergoline treatment clinically, biochemically, and radiologically. PMID:25002819

Alsubaie, Sadeem; Almalki, Mussa H

2014-01-01

346

Giant cystic lymphangioma of the liver  

PubMed Central

Background Giant cystic lymphangiomas of the liver are rare malformations of the lymphatic system usually found in children. Case presentation A 35-year-old man presenting with right upper quadrant abdominal pain for 7 months visited our clinic. Ultrasound, CT, and MRI examination demonstrated a giant cystic mass in the right trisegment of the liver. The patient underwent surgical resection and histological results of the resected specimen confirmed the diagnosis of giant cystic lymphangioma. The right upper quadrant abdominal pain subsided after the surgical resection and the patient recovered well. Conclusion Surgical resection is an effective therapy in treating giant cystic lymphangioma. PMID:21286352

Huang, Liang; Li, Jing; Zhou, Feiguo; Yan, Jianjun; Liu, Caifeng; Zhou, Anli Yue; Tang, Albert

2010-01-01

347

Calpain and lipopolysaccharide mediated hepatitis  

E-print Network

-mediated hepatitis model to investigate the mechanisms of hepatic neutrophil infiltration following LPS administration was developed by repeat intravenous injection of LPS at a dose of 10 mg/kg to rats. Blood was collected for hematologic and biochemical analysis...

Rose, Robert Edward

2009-06-02

348

Acute hepatic failure in children.  

PubMed Central

Many diseases may present as acute hepatic failure in the pediatric age group, including viral hepatitis A and B, adverse drug reactions, both toxic and "hepatitic," and inherited metabolic disorders such as tyrosinemia, alpha 1 antitrypsin deficiency, and Wilson's disease. Management is primarily supportive, with care taken to anticipate the known complications of hepatic failure. Few "curative" therapies are known, although attempts at stimulating hepatic regeneration may be helpful. Images FIG. 1 FIG. 3 FIG. 4 PMID:6433587

Riely, C. A.

1984-01-01

349

Immune Tolerant Hepatitis B  

PubMed Central

Chronic hepatitis B virus infection remains a global health concern, with perinatal transmission still a problem in many countries. Several new therapies for chronic hepatitis B virus infection have recently been introduced that can safely and effectively suppress viral replication with a low risk of resistance; thus, it has become increasingly tempting for many clinicians to treat patients in the immune tolerant stage of infection who have high levels of viremia yet persistently normal levels of transaminases. However, understanding the natural history of hepatitis B virus infection and how it pertains to disease progression, as well as how current therapies alter or do not alter this natural history, is important when deciding whether to treat these patients. This article will review the definition and natural history of immune tolerance, the current world guidelines and recommendations for treatment of immune tolerant patients, and data on the effectiveness of current therapies in this patient population. PMID:22298987

2011-01-01

350

[Pathophysiology of hepatic fibrosis].  

PubMed

Hepatic fibrosis is a common sequel to most forms of chronic liver disease and an essential component in the development of cirrhosis. Basic and clinical scientists have increasingly realized the importance of all elements of the liver in fibrogenesis, as well as of structural-functional relationships between liver cells and matrix components of the liver. Important is the recognition that hepatic stellate cells play a central role based on their ability to undergo activation following liver injury of any cause. The study brings about the newest information on pathophysiology of hepatic fibrosis. On the basis of better knowledge of the pathophysiology of fibrogenesis the development of new therapeutic approaches will become possible. PMID:11852583

Va?ková, M

2002-01-01

351

Oligarchic growth of giant planets  

E-print Network

Runaway growth ends when the largest protoplanets dominate the dynamics of the planetesimal disk; the subsequent self-limiting accretion mode is referred to as ``oligarchic growth.'' Here, we begin by expanding on the existing analytic model of the oligarchic growth regime. From this, we derive global estimates of the planet formation rate throughout a protoplanetary disk. We find that a relatively high-mass protoplanetary disk ($\\sim$ 10$\\times$ minimum-mass) is required to produce giant planet core-sized bodies ($\\sim$ 10 M$_{\\oplus}$) within the lifetime of the nebular gas ($\\la$ 10 million years). However, an implausibly massive disk is needed to produce even an Earth mass at the orbit of Uranus by 10 Myrs. Subsequent accretion without the dissipational effect of gas is even slower and less efficient. In the limit of non-interacting planetesimals, a reasonable-mass disk is unable to produce bodies the size of the Solar System's two outer giant planets at their current locations on {\\it any} timescale; if collisional damping of planetesimal random velocities is sufficiently effective, though, it may be possible for a Uranus/Neptune to form in situ in less than the age of the Solar System. We perform numerical simulations of oligarchic growth with gas, and find that protoplanet growth rates agree reasonably well with the analytic model as long as protoplanet masses are well below their estimated final masses. However, accretion stalls earlier than predicted, so that the largest final protoplanet masses are smaller than those given by the model. Thus the oligarchic growth model, in the form developed here, appears to provide an upper limit for the efficiency of giant planet formation.

Edward W. Thommes; Martin J. Duncan; Harold F. Levison

2003-03-12

352

Alcoholic hepatitis and concomitant hepatitis C virus infection.  

PubMed

Hepatitis C virus (HCV) infection and alcohol abuse are two most important causes of chronic liver disease in the United States. Alcoholic hepatitis is a unique clinical syndrome among patients with chronic and active alcohol abuse with a potential for high short-term mortality. About 20% of patients presenting with alcoholic hepatitis have concomitant HCV infection. Mortality from alcoholic hepatitis is increased in the presence of concomitant hepatitis C due to synergistic interaction between HCV and alcohol in causing hepatocellular damage. Large prospective randomized studies are needed to develop guidelines on the use of corticosteroids among patients with alcoholic hepatitis and concomitant HCV infection. The impact of antiviral therapy on mortality and outcome in the setting of alcoholic hepatitis remains a novel area for future research. PMID:25232227

Shoreibah, Mohamed; Anand, Bhupinderjit S; Singal, Ashwani K

2014-09-14

353

Hepatitis viruses: a pandora's box?  

PubMed

The term hepatitis virus is reserved for those viruses that are predominantly hepatotropic, although several new agents have been assigned to this category in the absence of hepatotropism and clinical disease. The hepatitis viruses can be broadly divided into those transmitted via the fecal-oral route, and those by blood, blood products and body fluids. Hepatitis A (picornaviridae), hepatitis B (hepadnaviridae) and hepatitis C (flaviviridae) represent the major public health problems. The epidemiology of hepatitis A virus (HAV) and hepatitis B virus (HBV) is changing in response to vaccination. In the case of HAV, older age groups are now deemed at risk, particularly of fulminant hepatitis if exposed over the age of 50. Chronic hepatitis B in some regions is now predominantly of the so-called precore mutant type where high levels of HBV replication persist in the presence of anti-hepatitis B virus (HBe) antibodies. The HBV vaccination is among the most cost-effective health care measures. The epidemiological significance of mutations found increasingly in the HBV S gene isolated from vaccinated children is unclear. Evidence that hepatitis G and TT virus are significant causes of hepatitis is lacking. Of interest, however, is the finding that the related GBV-B agent of monkeys may be a model for developing new antiviral agents against HCV. Animal models of hepatitis infections are providing new insights into the pathogenesis of hepatitis in humans. Indeed it is possible that hepatitis E is primarily an agent of pigs and other domesticated livestock. Intriguingly, the new TT virus shares many properties with the circoviruses, significant pathogens of chickens and pigs. The challenge in the next decade will be to assess the significance of these new agents in terms of public health and resources. Value judgements will have to be made in assessing the risks associated with blood containing trace amounts of these adventitious agents. PMID:12534779

Howard, Colin R

2002-12-01

354

Obscurin: a multitasking muscle giant  

Microsoft Academic Search

Obscurin (similar to 800 kDa) is the third member of a family of giant\\u000a proteins expressed in vertebrate striated muscle, along with titin\\u000a (3-3.7 MDa) and nebulin (similar to 800 kDa). Like its predecessors, it\\u000a is a multidomain protein composed of tandem adhesion modules and\\u000a signaling domains. Unlike titin and nebulin, which are integral\\u000a components of sarcomeres, obscurin is concentrated

Aikaterini Kontrogianni-Konstantopoulos; Robert J. Bloch

2005-01-01

355

Giant Sigmoid Diverticula: A Review  

PubMed Central

Two patients with giant sigmoid diverticula are added to 13 cases reported in the literature and the clinical features of this rare complication of diverticulosis are reviewed. These lesions probably arise as pseudodiverticula of the sigmoid colon with herniation of the mucosa through the muscle wall. They become progressively inflated by colonic gas via a ball-valve type mechanism. They are best treated by resection of the diverticulum, in continuity with the involved sigmoid, and primary anastomosis. ImagesFig. 1.Fig. 2.Fig. 3. PMID:4433171

Kempczinski, Richard F.; Ferrucci, Joseph T.

1974-01-01

356

The Giant of Gravel Hill  

E-print Network

Of Northumberland he was the Duke [Hugh Percy 3rd Duke 1785-1847 devt. football] And they were all a lucky group [High Steward 1834, Chancellor 1840] Because he went and bought that glass That product of Parisian craft. After him that ‘scope... , right, wrong and awry It’s not just sums - Astronomy It has a long, long history And if you find the words to fit A poem you can make of it! So that’s the story of Gravel Hill Where you can see that Giant still THE END! Poem by Mark...

Hurn, Mark

2013-12-18

357

Prevalence of Antibodies to Hepatitis C Virus in Chinese Patients with Viral Hepatitis and Hepatic Failure.  

National Technical Information Service (NTIS)

Anti-hepatitis C virus (anti-HCV) assay with ORTHO kits was done in 100 blood donors and recipients and 374 cases of viral hepatitis, including 65 cases of fulminant, subacute and chronic hepatic failure. None of the 100 blood donors and recipients showed...

D. Zhang, Y. Zhou, X. Jia

1992-01-01

358

Do red giants have short mode lifetimes?  

E-print Network

We show evidence that the red giant star ksi Hya has an oscillation mode lifetime, tau, of about 2 days significantly shorter than predicted by theory (tau = 17 days, Houdek & Gough 2002). If this is a general trend of red giants it would limit the prospects of asteroseismology on these stars because of poor coherence of the oscillations.

D. Stello; H. Kjeldsen; T. R. Bedding; D. Buzasi

2005-10-18

359

Integrable open spin chains from giant gravitons  

Microsoft Academic Search

We prove that in the presence of a maximal giant graviton state in Script N = 4 SYM, the states dual to open strings attached to the giant graviton give rise to an PSU(2,2|4) open spin chain model with integrable boundary conditions in the SO(6) sector of the spin chain to one loop order.

David Berenstein; Samuel E. Vázquez

2005-01-01

360

Giant monopole resonance strength in Si-28  

E-print Network

The giant resonance region in Si-28 was studied with inelastic scattering of 240 MeV alpha particles at small angles including 0 degrees. The giant resonance peak extended from E-x=12 MeV to 35 MeV and E0 strength corresponding to 54 +/- 6...

Youngblood, David H.; Clark, HL; Lui, YW.

1998-01-01

361

The Giant Panda is a Bear  

Microsoft Academic Search

EXOTIC habitat, rarity, striking coloration, and an appealing countenance have combined to surround the giant panda (Ailuropda melanoleuca) with an aura of mystery unmatched by most other mammals. Nonetheless, we really know little about the species, a lack perhaps best exemplified by the long-standing controversy about the giant panda's phylogenetic position among the arctoid (canoid plus pinniped) carnivores. There is

Vincent M. Sarich

1973-01-01

362

Statistics of Giant Arcs in Galaxy Clusters  

E-print Network

We study the expected properties and statistics of giant arcs produced by galaxy clusters in a LambdaCDM universe and investigate how the characteristics of CDM clusters determine the properties of the arcs they generate. Due to the triaxiality and substructure of CDM halos, the giant arc cross section for individual clusters varies by more than an order of magnitude as a function of viewing angle. In addition, the shallow density cusps and triaxiality of CDM clusters cause systematic alignments of giant arcs which should be testable with larger samples from forthcoming lensing surveys. We compute the predicted statistics of giant arcs for the LambdaCDM model and compare to results from previous surveys. The predicted arc statistics are in excellent agreement with the numbers of giant arcs observed around low redshift (0.2 0.6 clusters. This excess, if real, appears to be due to the presence of highly massive or concentrated clusters at high redshifts.

Neal Dalal; Gilbert Holder; Joseph Hennawi

2003-10-11

363

Safety of lamivudine treatment for chronic hepatitis B in early pregnancy  

PubMed Central

AIM: To evaluate the safety of lamivudine (LAM) treatment for chronic hepatitis B in early pregnancy. METHODS: A total of 92 pregnant women who received LAM treatment either before pregnancy or in early pregnancy were enrolled in this study. All of the pregnant women volunteered to take lamivudine during pregnancy and were not co-infected with hepatitis C virus, human immunode?ciency virus, cytomegalovirus, or other viruses. All infants received passive-active immunoprophylaxis with 200 IU hepatitis B immunoglobulin and three doses of 10 ?g hepatitis B vaccines (0-1-6 mo) according to the guidelines for the prevention and treatment of chronic hepatitis B. Adverse events were observed throughout the entire pregnancy and perinatal period, and the effectiveness of lamivudine treatment for blocking mother-to-infant transmission of hepatitis B virus (HBV) was evaluated. All adverse events in mothers and infants during pregnancy and the perinatal period and the HBV mother-to-infant transmission blocking rate were compared with the literature. RESULTS: Among the 92 pregnant women, spontaneous abortions occurred in 11 cases, while 3 mothers had a second pregnancy after the initial abortion; 72 mothers delivered 73 live infants, of whom 68 infants were followed up for no less than 6 mo, and 12 mothers were still pregnant. During pregnancy, the main maternal adverse events were vaginitis (12/72, 16.7%), spontaneous abortion (11/95, 11.6%), and gestational diabetes (6/72, 8.3%); only one case had 1-2 degree elevation of the creatine kinase level (195 U/L). During the perinatal period, the main maternal adverse events were premature rupture of the membranes (8/72, 11.1%), preterm delivery (5/72, 6.9%), and meconium staining of the amniotic fluid (4/72, 5.6%). In addition, 2 infants were found to have congenital abnormalities; 1 had a scalp hemangioma that did not change in size until 7 mo, and the other had early cerebral palsy, but with rehabilitation training, the infant’s motor functions became totally normal at 2 years of age. The incidence of adverse events among the mothers or abnormalities in the infants was not higher than that of normal mothers or HBV-infected mothers who did not receive lamivudine treatment. In only 2 cases, mother-to-infant transmission blocking failed; the blocking rate was 97.1% (66/68), which was higher than has been previously reported. CONCLUSION: Lamivudine treatment is safe for chronic HBV-infected pregnant mothers and their fetuses with a gestational age of less than 12 wk or throughout the entire pregnancy. PMID:23236240

Yi, Wei; Liu, Min; Cai, Hao-Dong

2012-01-01

364

Red giant collisions in the galactic centre  

E-print Network

We simulate collisions involving red-giant stars in the centre of our galaxy. Such encounters may explain the observed paucity of highly luminous red giants within the central 0.2pc. The masses of the missing stars are likely to be in the range 2 to 8 solar masses. Recent models of the galactic centre cluster's density and velocity distributions are used to calculate two-body collision rates. In particular we use stellar-evolution models to calculate the number of collisions a star will have during different evolutionary phases. We find that the number of two-body collisions per star is $\\lo 1$ in the central 0.1 to 0.2 pc, depending strongly on the galactocentric radius. Using a 3D numerical hydrodynamics code (SPH) we simulate encounters involving cluster stars of various masses with 2 and 8 solar-mass red giants. The instantaneous mass loss in such collisions is rarely enough to destroy either giant. A fraction of the collisions do, however, lead to the formation of common envelope systems where the impactor and giant's core are enshrouded by the envelope of the giant. Such systems may evolve to expel the envelope, leaving a tight binary; the original giant is destroyed. The fraction of collisions that produce common envelope systems is sensitive to the local velocity dispersion and hence galactocentric radius. Using our collision-rate calculations we compute the time-scales for a giant star to suffer such a collision within the galactic centre. These time-scales are >10^{9-10}years and so are longer than the lifetimes of stars more-massive than 2 solar masses. Thus the observed paucity of luminous giants is unlikely to be due to the formation of common envelope systems as a result of two-body encounters involving giant stars.

V. C. Bailey; M. B. Davies

1999-07-22

365

Photophoresis boosts giant planet formation  

NASA Astrophysics Data System (ADS)

In the core accretion model of giant planet formation, a solid protoplanetary core begins to accrete gas directly from the nebula when its mass reaches ~5 M?. The protoplanet has at most a few million years to reach runaway gas accretion, as young stars lose their gas disks after 10 million years at the latest. Yet gas accretion also brings small dust grains entrained in the gas into the planetary atmosphere. Dust accretion creates an optically thick protoplanetary atmosphere that cannot efficiently radiate away the kinetic energy deposited by incoming planetesimals. A dust-rich atmosphere severely slows down atmospheric cooling, contraction, and inflow of new gas, in contradiction to the observed timescales of planet formation. Here we show that photophoresis is a strong mechanism for pushing dust out of the planetary atmosphere due to the momentum exchange between gas and dust grains. The thermal radiation from the heated inner atmosphere and core is sufficient to levitate dust grains and to push them outward. Photophoresis can significantly accelerate the formation of giant planets.

Teiser, J.; Dodson-Robinson, S. E.

2013-07-01

366

Management of Hepatic Encephalopathy  

PubMed Central

Hepatic encephalopathy (HE), the neuropsychiatric presentation of liver disease, is associated with high morbidity and mortality. Reduction of plasma ammonia remains the central therapeutic strategy, but there is a need for newer novel therapies. We discuss current evidence supporting the use of interventions for both the general management of chronic HE and that necessary for more acute and advanced disease. PMID:21994873

Wright, G.; Chattree, A.; Jalan, R.

2011-01-01

367

Viral hepatitis in Bucharest.  

PubMed

A seroprevalence survey of viral hepatitis was conducted in Bucharest, Romania, between April and July 1990 on a systematic sample of 1355 persons drawn from the general population and groups at higher risk of infection. Sera were tested for hepatitis A, B, and C (HAV, HBV and HCV, resp.) markers using an enzyme-linked immunosorbent assay (ELISA) method. The prevalences of HAV and HBV markers were high in all groups. A total of 47% of the adults from the general population and 39.8% of the children aged 0-16 years had at least one HBV marker. Of the pregnant women 7.8% were positive for hepatitis B surface antigen. Among infants (0-3 years of age) living in orphanages, the prevalence of at least one HBV marker was 54.6%. The findings also confirmed that HCV was circulating in Romania. The results are consistent with national surveillance data and confirm that viral hepatitis is a major public health problem in Romania. Preventive measures will have to include HBV immunization of infants, with an appropriately targeted immunization strategy being determined through further epidemiological studies. PMID:8313496

Paquet, C; Babes, V T; Drucker, J; Sénémaud, B; Dobrescu, A

1993-01-01

368

The hepatitis B virus  

Microsoft Academic Search

DNA recombinant technology has radically changed hepatitis B virus (HBV) virology. The genetic organization, transcription and replication of the virus are basically understood, structures of integrated HBV sequences in hepatocellular carcinoma have been characterized, and new vaccines produced by recombinant DNA technique are being developed.

Pierre Tiollais; Christine Pourcel; Anne Dejean

1985-01-01

369

P. Roingeard -Journal of Viral Hepatitis 2013 ; 20, 77-84. Page 1 Hepatitis C virus diversity and hepatic steatosis  

E-print Network

of chronic liver disease, such as hepatitis B or autoimmune hepatitis. This suggests a probable direct roleP. Roingeard - Journal of Viral Hepatitis 2013 ; 20, 77-84. Page 1 REVIEW Hepatitis C virus diversity and hepatic steatosis P. Roingeard. INSERM U966, Université François Rabelais & CHRU de Tours, 10

Paris-Sud XI, Université de

370

[Therapy of hepatitis C].  

PubMed

The purpose of this review is an update of the therapy of hepatitis C especially with Interferon-alpha. From the large number of publications on this topic the established facts were worked out. Taking these facts as a base guidelines for the therapy in practical use were defined. In addition the aspects of therapeutic strategies of chronic hepatitis C which until now can not definitely be judged are discussed. In the relatively few patients in whom hepatitis C is diagnosed already in the acute phase, Interferon-alpha-treatment (3 x 3 million units 3 times a week) for 3 to 4 months increases the percentage of patients in whom HCV-RNA in the serum is eliminated. In patients with chronic hepatitis C, after decision finding for treatment, a standard scheme is recommended which consists of a monotherapy with recombinant Interferon-alpha. The dosage of Interferon-alpha is in the first 12 to 16 weeks 5 up to 6 million units given 3 times a week. For the further therapy 3 million units 3 times a week seems to be appropriate. The recommended duration of Interferon-alpha-therapy is 12 months. A long-term benefit of about 20% can be achieved in unselected groups of patients when judged on the permanent normalisation of serum transaminases and elimination of HCV-RNA in the serum. Important factors which may influence the probability of a sustained response, like HCV genotype, virus titer in serum, duration of the disease, high hepatic iron content and the presence of cirrhosis, are discussed. Up to now there exist no reliable guidelines in the case of a "no change" situation and for patients with a flare-up of inflammatory activity during or after therapy. Combination therapy of Interferon-alpha with other drugs like analogous of nucleotides (for example ribavarin), non steroidal antirheumatic drugs and ursodesoxycholic acid (UDCA) have still to be evaluated in controlled clinical trials. PMID:9173207

Alscher, D M; Bode, J C

1997-03-15

371

Separating gas-giant and ice-giant planets by halting pebble accretion  

NASA Astrophysics Data System (ADS)

In the solar system giant planets come in two flavours: gas giants (Jupiter and Saturn) with massive gas envelopes, and ice giants (Uranus and Neptune) with much thinner envelopes around their cores. It is poorly understood how these two classes of planets formed. High solid accretion rates, necessary to form the cores of giant planets within the life-time of protoplanetary discs, heat the envelope and prevent rapid gas contraction onto the core, unless accretion is halted. We find that, in fact, accretion of pebbles (~cm sized particles) is self-limiting: when a core becomes massive enough it carves a gap in the pebble disc. This halt in pebble accretion subsequently triggers the rapid collapse of the super-critical gas envelope. Unlike gas giants, ice giants do not reach this threshold mass and can only bind low-mass envelopes that are highly enriched by water vapour from sublimated icy pebbles. This offers an explanation for the compositional difference between gas giants and ice giants in the solar system. Furthermore, unlike planetesimal-driven accretion scenarios, our model allows core formation and envelope attraction within disc life-times, provided that solids in protoplanetary discs are predominantly made up of pebbles. Our results imply that the outer regions of planetary systems, where the mass required to halt pebble accretion is large, are dominated by ice giants and that gas-giant exoplanets in wide orbits are enriched by more than 50 Earth masses of solids.

Lambrechts, M.; Johansen, A.; Morbidelli, A.

2014-12-01

372

THE ORBITAL EVOLUTION OF GAS GIANT PLANETS AROUND GIANT STARS  

SciTech Connect

Recent surveys have revealed a lack of close-in planets around evolved stars more massive than 1.2 M{sub sun}. Such planets are common around solar-mass stars. We have calculated the orbital evolution of planets around stars with a range of initial masses, and have shown how planetary orbits are affected by the evolution of the stars all the way to the tip of the red giant branch. We find that tidal interaction can lead to the engulfment of close-in planets by evolved stars. The engulfment is more efficient for more-massive planets and less-massive stars. These results may explain the observed semimajor axis distribution of planets around evolved stars with masses larger than 1.5 M{sub sun}. Our results also suggest that massive planets may form more efficiently around intermediate-mass stars.

Villaver, Eva [Universidad Autonoma de Madrid, Departamento de fisica Teorica C-XI, 28049 Madrid (Spain); Livio, Mario, E-mail: eva.villaver@uam.e, E-mail: mlivio@stsci.ed [Space Telescope Science Institute, 3700 San Martin Drive, Baltimore, MD 21218 (United States)

2009-11-01

373

Two Giant Planets Orbiting the K Giant Star ? Cet  

NASA Astrophysics Data System (ADS)

We present evidence of a new planetary system around the K giant ? Cet (HIP 5364, HD 6805, HR 334), based on 124 high-precision optical and infrared radial velocity data, taken at Lick Observatory (Hamilton) and at VLT (CRIRES). The best dynamical fit to the data is consistent with two massive planets (m 1sini~2.6M Jup , m 2sini~3.3MJup ) and with periods of P 1~407 days, P 2~740 days. To test the ? Cet system's stability we perform ~ 10,000 dynamical investigations with maximum time spans of 108 years. We find that in case of moderate eccentricities, the planets can be effectively trapped in an anti-aligned stable 2:1 mean motion resonance (MMR), very close to the separatrix. A larger non-resonant stable region exists in low-eccentricity parameter space, although less probable than the 2:1 MMR region.

Trifonov, T.; Reffert, S.; Tan, X.; Lee, M. H.; Quirrenbach, A.

2014-01-01

374

VACCINE INFORMATION STATEMENT Hepatitis A Vaccine  

E-print Network

VACCINE INFORMATION STATEMENT Hepatitis A Vaccine What You Need to Know Many Vaccine Information 1,000 cases). Hepatitis A vaccine can prevent hepatitis A. 2 Who should get hepatitis A vaccine and when? WHO? Some people should be routinely vaccinated with hepatitis A vaccine: · All children between

Leistikow, Bruce N.

375

Clinical management of hepatic encephalopathy.  

PubMed

The number of patients with cirrhosis in the United States continues to rise, and 30-45% of these patients are expected to develop hepatic encephalopathy. A broad spectrum of clinical manifestations is seen with the disorder, including mental or personality changes, asterixis, decreased energy level, impaired cognition, impaired sleep-wake cycle, decreased hand-eye coordination, psychomotor retardation, and incessant talking. Hepatic encephalopathy is a clinical diagnosis, and several scoring systems have been used to determine the severity of hepatic encephalopathy. The West Haven Criteria appear to be the scoring system most frequently used. Minimal hepatic encephalopathy has been reported to affect 60-70% of patients with cirrhosis and is predictive of the development of overt hepatic encephalopathy. An estimated 10-50% of patients who have undergone a transjugular intrahepatic portosystemic shunt for variceal bleeding develop hepatic encephalopathy. A great amount of attention has centered on the role of ammonia in hepatic encephalopathy, but that role is still largely hypothetical. Lactulose has been used for many years to minimize the effects of hepatic encephalopathy; however, noncompliance with lactulose is a common cause of rehospitalization. The pathophysiology of hepatic encephalopathy is extremely complex, and formal treatment guidelines are grossly outdated. The survival rate after 3 years among patients with hepatic encephalopathy is only 25%. PMID:20412035

Schiano, Thomas D

2010-05-01

376

Red giant variables: OGLE--II and MACHO  

E-print Network

We review the recent impact of microlensing projects on our understanding of pulsating red giant stars. Discussed are red giant stars' pulsation properties (period--luminosity relations, period changes, mode switchings), Red Giant Branch pulsations, metallicity effects and the use of red giant variables to explore galactic structure.

L. L. Kiss; P. Lah

2005-09-21

377

[Giant cell in maxillary pseudotumors].  

PubMed

A research on lesions apparently tumorous that appear on jawbones and are not exactly tumors is developed. These lesions are clinically silent, although they produce deformity and, perhaps because of that, an early diagnosis with biopsy or other procedures is needed. The image research can be very characteristic or otherwise, it can be very complex, non specific and not provide everything expected to make the diagnosis. The difference between radiolucent and radiopaque images that produce the querubism-fibrous displasia, prove both extremes in which the diagnosis judgment made by image can or cannot be significant. We have to highlight the presence of giant cells with an osteoclastic nature in most of these pseudo tumorous lesions. PMID:23350337

Lucas Tomás, Miguel; Sanz Serrula, Javier; De Lucas, Mónica; De Lucas, Ignacio

2011-01-01

378

Terrestrial versus giant planet formation  

NASA Technical Reports Server (NTRS)

Given a solar nebular surrounding the early protosun, containing dust grains that have already undergone growth through collisions to about centimeter-size, the question of the formation of the terrestrial and giant planets is considered. In contrast to the usual approach of emphasizing how well a problem is understood, the uncertainties and areas where more work needs to be done will be accentuated. Also, the emphasis will be on the dynamics of planetary formation, because profound problems still exist in this area, and because it seems most logical to concentrate first on the dynamical questions involved with assembling the planets before putting too much effort into the detailed chemical and geological consequences of certain formation mechanisms.

Boss, Alan P.

1988-01-01

379

Giant tunneling magnetoresistance in silicene  

SciTech Connect

We have theoretically studied ballistic electron transport in silicene under the manipulation of a pair of ferromagnetic gate. Transport properties like transmission and conductance have been calculated by the standard transfer matrix method for parallel and antiparallel magnetization configurations. It is demonstrated here that, due to the stray field-induced wave-vector filtering effect, remarkable difference in configuration-dependent transport gives rise to a giant tunneling magnetoresistance. In combination with the peculiar buckled structure of silicene and its electric tunable energy gap, the receiving magnetoresistance can be efficiently modulated by the externally-tunable stray field, electrostatic potential, and staggered sublattice potential, providing some flexible strategies to construct silicene-based nanoelectronic device.

Wang, Yu, E-mail: ywang@semi.ac.cn [Department of Physics, Faculty of Science, Kunming University of Science and Technology, Kunming, 650500 Yunnan (China); Lou, Yiyi [Yiyuan Student Community, Center of Student Community Education and Management, Kunming University of Science and Technology, Kunming, 650500 Yunnan (China)

2013-11-14

380

Peripheral giant cell granuloma: a case report.  

PubMed

The peripheral giant cell granuloma is a reactive lesion of the soft tissue of the oral cavity. Clinical appearance ranges from normal tissue coloration to dark red or purplish. These are elevated lesions generally 5-15 mm in diameter. Etiology is considered to be chronic irritation. To decrease the risk of clinical recurrence, treatment is complete excision to include the underlying periosteum. Histologic features of the peripheral giant cell granuloma include multinucleated giant cells with a stroma that may contain osteoblasts, myofibroblasts, macrophages, and Langerhans cells. A case report is presented. PMID:12004669

Breault, L G; Fowler, E B; Wolfgang, M J; Lewis, D M

2000-01-01

381

Hydrodynamic Simulations of Giant Impacts  

NASA Astrophysics Data System (ADS)

We studied the basic numerical aspects of giant impacts using Smoothed Particles Hydrodynamics (SPH), which has been used in most of the prior studies conducted in this area (e.g., Benz, Canup). Our main goal was to modify the massive parallel, multi-stepping code GASOLINE widely used in cosmological simulations so that it can properly simulate the behavior of condensed materials such as granite or iron using the Tillotson equation of state. GASOLINE has been used to simulate hundreds of millions of particles for ideal gas physics so that using several millions of particles in condensed material simulations seems possible. In order to focus our attention of the numerical aspects of the problem we neglected the internal structure of the protoplanets and modelled them as homogenous (isothermal) granite spheres. For the energy balance we only considered PdV work and shock heating of the material during the impact (neglected cooling of the material). Starting at a low resolution of 2048 particles for the target and the impactor we run several simulations for different impact parameters and impact velocities and successfully reproduced the main features of the pioneering work of Benz from 1986. The impact sends a shock wave through both bodies heating the target and disrupting the remaining impactor. As in prior simulations material is ejected from the collision. How much, and whether it leaves the system or survives in an orbit for a longer time, depends on the initial conditions but also on resolution. Increasing the resolution (to 1.2x10? particles) results in both a much clearer shock wave and deformation of the bodies during the impact and a more compact and detailed "arm" like structure of the ejected material. Currently we are investigating some numerical issues we encountered and are implementing differentiated models, making one step closer to more realistic protoplanets in such giant impact simulations.

Reinhardt, Christian; Stadel, Joachim

2013-07-01

382

The accretion of brown dwarfs and planets by giant stars - II. Solar-mass stars on the red giant branch  

Microsoft Academic Search

This paper extends our previous study of planet\\/brown dwarf accretion by giant stars to solar-mass stars located on the red giant branch. The model assumes that the planet is dissipated at the bottom of the convective envelope of the giant star. The evolution of the giant is then followed in detail. We analyse the effects of different accretion rates and

Lionel Siess; Mario Livio

1999-01-01

383

Studies on the ingestion characteristics of giant freshwater prawn, Chinese prawn and giant tiger prawn  

NASA Astrophysics Data System (ADS)

The ingestion of giant freshwater prawn, Chinese prawn and giant tiger prawn had continuity and the ingestion high peak occurred at night. Light and temperature had significant effects on the daily ingestion rate (DIR) of giant freshwater prawn Macrobrachium rosenbergii. Red light and blue light favorably induced favorable ingestion. In the adaptive range of temperature, the DIR increased with rising temperature and feeding frequency, but decreased with rising body weight.

Zang, Wei-Ling; Wang, Wei-Dong; Dai, Xi-Lin; Jiang, Min; Zhu, Zheng-Guo; Yang, Ming-Hui; Liu, Xian-Zhong; Xu, Gui-Rong; Ding, Fu-Jiang

2000-12-01

384

Hepatic sinusoidal ectasia.  

PubMed

Oral contraceptive-associated sinusoidal ectasia is a rare lesion of unknown pathogenesis. We describe the case of a 31-year-old woman who had used oral contraceptives for 10 years and was found to have abnormal liver function tests on "routine" examination. A single 9 x 5 x 4 cm hypervascular lesion was demonstrated radiographically. The hepatic immuno-diacetic acid and liver-spleen scans were normal. One subcapsular lesion was identified in the resected right hepatic lobe; it was characterized by focal marked dilatation of the sinusoidal spaces associated with rare hepatocyte necrosis and early intrasinusoidal fibrosis. The subcapsular location and the vascular nature of this wedge-shaped lesion suggest it may represent the telangiectatic precursor of a centrally scarred focal nodular hyperplasia. PMID:1644440

Oligny, L L; Lough, J

1992-08-01

385

Origin of hepatitis ? virus  

PubMed Central

This article addresses some of the questions relating to how hepatitis ? virus (HDV), an agent so far unique in the animal world, might have arisen. HDV was discovered in patients infected with hepatitis B virus (HBV). It generally makes HBV infections more damaging to the liver. It is a subviral satellite agent that depends upon HBV envelope proteins for its assembly and ability to infect new cells. In other aspects of replication, HDV is both independent of and very different from HBV. In addition, the small single-stranded circular RNA genome of HDV, and its mechanism of replication, demonstrate an increasing number of similarities to the viroids – a large family of helper-independent subviral agents that cause pathogenesis in plants. PMID:20210550

Taylor, John; Pelchat, Martin

2010-01-01

386

Testing for the Hepatitis C Virus  

MedlinePLUS

... Consumer Summary – Sept. 13, 2013 Testing for the Hepatitis C Virus Formats View PDF (PDF) 999 kB ... for this summary. Understanding the Condition What is hepatitis C? Hepatitis C is a disease caused by ...

387

Surveillance for Viral Hepatitis - United States, 2012  

MedlinePLUS

... PPTX - 832KB] Hepatitis B virus PAGE DESCRIPTION Table 3.1 Reported cases of acute hepatitis B, by state ? ... characteristic and year – United States, 2007-2011 Slide 3.1 Reported number of acute hepatitis B cases — United ...

388

Viral Hepatitis: A through E and Beyond  

MedlinePLUS

... when traveling internationally and practicing good hygiene and sanitation also help prevent hepatitis A. What is the ... when traveling internationally and practicing good hygiene and sanitation. What is the treatment for hepatitis E? Hepatitis ...

389

Chronic hepatitis B  

Microsoft Academic Search

Opinion statement  Interferon alpha, lamivudine, and adefovir are the three drugs currently approved for the treatment of chronic hepatitis B\\u000a virus (HBV). There are pros and cons associated with the use of each drug. Individualization of therapy, based upon factors\\u000a such as patient comorbidities, response to prior therapies, and stage of disease, is recommended. Patients with abnormal liver\\u000a enzymes, indices of

Stephanie D. Straley; Norah A. Terrault

2004-01-01

390

Hepatic Venous Outflow Obstruction  

Microsoft Academic Search

\\u000a The liver is the largest organ in the body and its dual blood supply makes it a unique organ. Although it makes up less than\\u000a 3% of total body weight (about 1,800 g in men and 1,400 g in women), the liver receives one-quarter of the total cardiac output\\u000a via the hepatic artery and portal vein [1]. Classically, the liver

Yusuf Bayraktar

391

Hepatitis C and pregnancy  

PubMed Central

Acute hepatitis C is a rare event in pregnancy. The most common scenario is chronic hepatitis C virus (HCV) infection in pregnancy. During pregnancy in women with chronic HCV infection a significant reduction in mean alanine aminotransferase levels has been reported, with a rebound during the postpartum period. In few cases exacerbation of chronic hepatitis C has been reported in pregnancy. A cofactor that might play a role in the reduction of liver damage is the release of endogenous interferon from the placenta. Observations regarding serum HCV-RNA concentration have been variable. In some women HCV-RNA levels rise toward the end of pregnancy. In general, pregnancy does not have a negative effect on HCV infection. Conversely, chronic hepatitis does not appear to have an adverse effect on the course of pregnancy, or the birth weight of the newborn infant. The role of spontaneous abortion is approximately the same as in the general population. The overall rate of mother-to-child transmission for HCV is 3%-5% if the mother is known to be anti-HCV positive. Co-infection with human immunodeficiency virus (HIV) increases the rate of mother-to-child transmission up to 19.4%. Numerous risk factors for vertical transmission have been studied. In general, high viral load defined as at least 2.5 × 106 viral RNA copies/mL, HIV co-infection, and invasive procedures are the most important factors. Both interferon and ribavirin are contraindicated during pregnancy. Viral clearance prior to pregnancy increases the likelihood that a woman remains non-viremic in pregnancy with a consequent reduced risk of vertical transmission. PMID:24187446

Floreani, Annarosa

2013-01-01

392

Ciliated hepatic foregut cyst  

Microsoft Academic Search

Ciliated hepatic foregut cyst is a rare, benign, most often solitary and unilocular, rarely multilocular cyst made up of a\\u000a ciliated pseudostratified columnar epithelium, a subepitheial connective tissue layer, a smooth muscle layer and an outer\\u000a fibrous capsule. The lesion is usually found incidentally by ultrasonography, during surgical exploration or autopsy. Recent\\u000a publications characterizes of its fine needle aspiration biopsy

Barna Bogner; Géza Hegedûs

2002-01-01

393

[Acute hepatic vascular complications].  

PubMed

Acute hepatic vascular complications are rare. Acute portal vein thrombosis (PVT) and the Budd-Chiari syndrome (BSC) are the leading causes. Coagulopathy and local factors are present in up to 80% of cases. Diagnosis is established by colour-coded Doppler sonography, contrast-enhanced computed tomography or magnetic resonance imaging. Patients with acute PVT present with abdominal pain and disturbed intestinal motility. In the absence of cirrhosis anticoagulation with heparin is established followed by oral anticoagulation. In severe cases, surgical thrombectomy or transjugular thrombolysis with stent shunt may be necessary. Acute or fulminant BCS may require emergency liver transplantation or a transjugular intrahepatic portosystemic stent shunt, if patients present with acute liver failure. Milder cases receive anticoagulation for thrombolysis of occluded hepatic veins. Sinusoidal obstruction syndrome (SOS) is diagnosed after total body irradiation or chemotherapy, the term SOS replacing the former veno-occlusive disease. The treatment of congenital vascular malformations, complications in the setting of OLTX as well as patients with hepatic involvement of hereditary hemorrhagic telangiectasia requires significant expertise in a multidisciplinary approach. PMID:21667100

Ochs, A

2011-07-01

394

Alcoholic hepatitis: current management.  

PubMed

Alcoholic hepatitis is an acute manifestation of alcoholic liver disease with mortality as high as 40-50 % in severe cases. Patients usually have a history of prolonged alcohol abuse with or without a known history of liver disease. Although there is significant range in severity at presentation, patients with severe alcoholic hepatitis typically present with anorexia, fatigue, fever, jaundice, and ascites. The use of either pentoxifylline or corticosteroids in those with severe disease (Maddrey's discriminate function >32) has significant mortality benefit. The addition of N-acetylcysteine to corticosteroids decreases the incidences of hepatorenal syndrome, infection, and short-term mortality, but does not appear to significantly affect 6-month mortality. Nutritional support with high-calorie, high-protein diet is recommended in all patients screening positive for malnutrition. Liver transplantation for a highly selected group of patients with severe alcoholic hepatitis may be an option in the future, but is not currently recommended or available at most transplant institutions. PMID:24798996

Spengler, Erin K J; Dunkelberg, Jeffrey; Schey, Ron

2014-10-01

395

Therapy of chronic viral hepatitis.  

PubMed

Chronic infection with hepatitis B virus (HBV), the delta agent (HDV) or hepatitis C virus (HCV) carries high risks of chronic liver disease which can result in cirrhosis and hepatocellular carcinoma. Many antiviral agents have been tried to inhibit viral replication and thereby limit infectivity and the risks of eventual serious liver disease. Interferon offers a 30-40% chance of viral clearance to the hepatitis B carrier, offers a good chance of clinical response in parenterally acquired chronic non-A non-B hepatitis and may be of benefit for some patients with chronic delta infection. PMID:1716277

Main, J

1991-06-01

396

Hepatitis C in haematological patients.  

PubMed

There is no consensus guideline concerning the management of chronic hepatitis C patients during chemotherapy, and immunosuppression. However, there are some suggestions in literature that hepatitis C viral load increases during chemotherapy and there is a risk of rebound immunity against hepatitis C after discontinuation of immunosuppression with a consequent liver injury. A close monitoring of liver function of these patients is prudent during treatment of haematological malignancy. Antiviral treatment is deferred after the completion of chemotherapy and recovery of patients' immunity to minimize the toxicity of treatment. A combination of pegylated interferon and ribavirin is the standard therapy in hepatitis C infected haematological patients. PMID:21188204

Hwang, Y Y; Liang, R H S

2010-01-01

397

Serological diagnosis of acute viral hepatitis  

Microsoft Academic Search

Fifty cases of symptomatic acute viral hepatitis presenting at the Washington, D.C., Veterans Administration Medical Center between 1976 and 1977 were tested for serological markers of hepatitis virus infection. The etiology of the acute hepatitis appeared to be hepatitis A virus in 20%, hepatitis B virus in 52%, non-A, non-B agents in 22%, delta hepatitis in 4%, and infectious mononucleosis

Jay H. Hoofnagle; Antonio Ponzetto; Lars R. Mathiesen; Jeanne G. Waggoner; Z. Buskell Bales; Leonard B. Seeff

1985-01-01

398

A Giant Among Giants: Probing the Environment of the Giant Radio Galaxy 2146+82  

NASA Astrophysics Data System (ADS)

The dramatic influence of radio galaxies on the ambient thermal gas in clusters has been revealed through Chandra and XMM images of cooling core systems. In addition to the sources modifying the thermal gas, the dense ICM impacts the radio source through confinement of the jets and entrainment of material. In this proposal we target the radio source NVSS 2146+82 which a member of a rare class of galaxies known as giant radio galaxies. This system extends over more than 3 Mpc and appears to be associated with an unusually rich (richness class 0 or 1 cluster) environment for this type of system. The formation mechanism for these systems is unknown, but the proposed observations will provide the first firm details on the environment of a GRG for comparison with other cluster systems.

Clarke, Tracy

2005-10-01

399

Red giant depletion in globular cluster cores  

E-print Network

We investigate the observed depletion of red giants in the cores of post-core-collapse globular clusters. In particular, the evolutionary scenario we consider is a binary consisting of two low-mass stars which undergoes two common envelope phases. The first common envelope phase occurs when the primary is a red giant resulting in a helium white dwarf and main sequence star in a detached binary. The second common envelope phase occurs shortly after the secondary becomes a red giant. During the second common envelope phase the degenerate helium cores merge resulting in a core mass greater than the helium burning limit and the formation of a horizontal branch star. We show that this evolutionary route is enhanced in post-core-collapse clusters by stellar encounters. These encounters increase the population of binary secondaries which would have evolved onto the red giant branch in the recent past.

Martin E. Beer; Melvyn B. Davies

2003-01-23

400

Giant salivary calculi of the submandibular gland  

PubMed Central

Sialolithasis is the most common salivary gland disease. A case of an unusually large sialolith arising in the submandibular gland is presented, along with a review of the management of giant salivary gland calculi. PMID:24960792

Fowell, C; MacBean, A

2012-01-01

401

Giant cell tumor of the talar neck.  

PubMed

We describe a patient with a giant cell tumor in the talar head and neck of the left foot who was diagnosed as having osteochondritis dissecans and treated with arthroscopic drilling in this same location 3 years earlier. Giant cell tumors can be confused with several conditions, including giant cell reparative granulomas, brown tumors, and aneurysmal bone cysts. Giant cell tumors of bone typically occur in the epiphysis of long bones, including the distal femur and proximal tibia. They are uncommonly found in the small bones of the foot or ankle, and talar involvement is rare. Despite this rarity, the radiographic appearance and clinical signs of talar lesions should be considered in the differential diagnosis of nontraumatic conditions in the foot. PMID:17507533

Selek, Hakan; Ozer, Hamza; Turanli, Sacit; Erdem, Ozlem

2007-01-01

402

Radioembolization of hepatic tumors  

PubMed Central

Unresectable primary and metastatic liver tumors are a leading cause of cancer mortality and morbidity. This remains a challenging and key task for every oncologist despite significant advances that have been made with selective targeted systemic agents and in technology advances with radiotherapy delivery. Radioembolization (RE) is a technique of permanently implanting microspheres containing Yttrium-90 (90Y), a beta-emitting isotope with a treatment range of 2 mm, into hepatic tumors. This form of brachytherapy utilizes the unique dual vascular anatomy of the liver to preferentially deliver radioactive particles via the hepatic artery to tumor, sparing normal liver parenchyma. The main treatment inclusion criteria are patients with solid tumors, compensated liver functions, life expectancy of at least three months, and ECOG performance status 0-2. Benefit of RE has been proven in patients that have low-to-moderate extrahepatic disease burden, prior liver radiotherapy, heavy prior chemotherapy and biologic agent exposure, and history of hepatic surgery or ablation. Most of the clinical evidence is reported in metastatic colorectal, and neuroendocrine tumors (NET), and primary hepatocellular cancer. A growing body of data supports the use of RE in hepatic metastatic breast cancer, intrahepatic cholangiocarinoma, and many other metastatic tumor types. Side effects are typically mild constitutional and GI issues limited to the first 7-14 days post treatment, with only 6% grade 3 toxicity reported in large series. Potentially serious or fatal radiation induced liver disease is extremely rare, reported in only 1% or fewer in major series of both metastatic and primary tumors treated with RE. Currently, high priority prospective clinical trials are testing RE combined with chemotherapy in first line therapy for colorectal hepatic metastases, and combined with sorafenib for hepatocellular carcinomas (HCCs). Fortunately, this beneficial and now widely available therapy is being increasingly incorporated into the standard therapy algorithms of multidisciplinary GI cancer teams worldwide. This form of radiotherapy differs significantly from daily external beam radiotherapy in many ways, particularly in dose rate, dosimetric coverage and duration of radiation delivery, side effects, and patient selection factors. A wealth of experience using RE in solid tumors exists and ongoing major prospective clinical trials will soon clarify the role of RE in the management of metastatic colorectal liver metastases. PMID:24982766

2014-01-01

403

Radioembolization of hepatic tumors.  

PubMed

Unresectable primary and metastatic liver tumors are a leading cause of cancer mortality and morbidity. This remains a challenging and key task for every oncologist despite significant advances that have been made with selective targeted systemic agents and in technology advances with radiotherapy delivery. Radioembolization (RE) is a technique of permanently implanting microspheres containing Yttrium-90 ((90)Y), a beta-emitting isotope with a treatment range of 2 mm, into hepatic tumors. This form of brachytherapy utilizes the unique dual vascular anatomy of the liver to preferentially deliver radioactive particles via the hepatic artery to tumor, sparing normal liver parenchyma. The main treatment inclusion criteria are patients with solid tumors, compensated liver functions, life expectancy of at least three months, and ECOG performance status 0-2. Benefit of RE has been proven in patients that have low-to-moderate extrahepatic disease burden, prior liver radiotherapy, heavy prior chemotherapy and biologic agent exposure, and history of hepatic surgery or ablation. Most of the clinical evidence is reported in metastatic colorectal, and neuroendocrine tumors (NET), and primary hepatocellular cancer. A growing body of data supports the use of RE in hepatic metastatic breast cancer, intrahepatic cholangiocarinoma, and many other metastatic tumor types. Side effects are typically mild constitutional and GI issues limited to the first 7-14 days post treatment, with only 6% grade 3 toxicity reported in large series. Potentially serious or fatal radiation induced liver disease is extremely rare, reported in only 1% or fewer in major series of both metastatic and primary tumors treated with RE. Currently, high priority prospective clinical trials are testing RE combined with chemotherapy in first line therapy for colorectal hepatic metastases, and combined with sorafenib for hepatocellular carcinomas (HCCs). Fortunately, this beneficial and now widely available therapy is being increasingly incorporated into the standard therapy algorithms of multidisciplinary GI cancer teams worldwide. This form of radiotherapy differs significantly from daily external beam radiotherapy in many ways, particularly in dose rate, dosimetric coverage and duration of radiation delivery, side effects, and patient selection factors. A wealth of experience using RE in solid tumors exists and ongoing major prospective clinical trials will soon clarify the role of RE in the management of metastatic colorectal liver metastases. PMID:24982766

Kennedy, Andrew

2014-06-01

404

Granuloma with langhans giant cells: An overview  

PubMed Central

Granuloma formation with multinucleated giant cells is seen in numerous diseases. A granuloma is a focus of chronic inflammation consisting of a microscopic aggregation of macrophages surrounded by a collar of lymphocytes and plasma cells. In this article, we present a case of granuloma formation with multiple Langhans giant cells along with an overview of the differential diagnoses, which include mycobacterium diseases, other bacterial infections, fungal infections, protozoal infections, and other granulomatous diseases. PMID:24574664

Kumar, S Nalin; Prasad, T Srinivasa; Narayan, P Anantha; Muruganandhan, J

2013-01-01

405

FLAMES observations of Bulge Clump giants  

NASA Astrophysics Data System (ADS)

We present our first abundance results of 14 bulge clump giants using high resolution spectra obtained with FLAMES/UVES at the ESO/VLT, for which we measured metallicity and ?-elements. This work announces and characterizes our ongoing analysis of 228 clump giants observed with the medium high resolution spectrograph GIRAFFE. These chemical data combined with kinematical data will help to characterize the bulge population, determine the possible correlation between kinematical parameters and metallicity and provide clues to its formation process.

Lecureur, A.; Hill, V.

2005-12-01

406

Formation of Giant Planets and Brown Dwarves  

NASA Technical Reports Server (NTRS)

According to the prevailing core instability model, giant planets begin their growth by the accumulation of small solid bodies, as do terrestrial planets. However, unlike terrestrial planets, the growing giant planet cores become massive enough that they are able to accumulate substantial amounts of gas before the protoplanetary disk dissipates. Models predict that rocky planets should form in orbit about most stars. It is uncertain whether or not gas giant planet formation is common, because most protoplanetary disks may dissipate before solid planetary cores can grow large enough to gravitationally trap substantial quantities of gas. Ongoing theoretical modeling of accretion of giant planet atmospheres, as well as observations of protoplanetary disks, will help decide this issue. Observations of extrasolar planets around main sequence stars can only provide a lower limit on giant planet formation frequency . This is because after giant planets form, gravitational interactions with material within the protoplanetary disk may cause them to migrat inwards and be lost to the central star. The core instability model can only produce planets greater than a few jovian masses within protoplanetary disks that are more viscous than most such disks are believed to be. Thus, few brown dwarves (objects massive enough to undergo substantial deuterium fusion, estimated to occur above approximately 13 jovian masses) are likely to be formed in this manner. Most brown dwarves, as well as an unknown number of free-floating objects of planetary mass, are probably formed as are stars, by the collapse of extended gas/dust clouds into more compact objects.

Lissauer, Jack J.

2003-01-01

407

Giant cell ependymoma: a case report.  

PubMed

Ependymomas account for 3-9% of all neuroepithelial tumors. A peculiar variant of ependymoma known as "giant cell ependymoma" ("GCE") is especially rarely reported, it may pose some difficulties for the diagnosing neuropathologist. Here we present a case of a giant cell ependymoma occuring in a 17-year-old patient with the history of 2-year recurrent headaches and a 1-month history of vision impairment. CT scanning demonstrated a mass in the left occipital lobe, arising from the occipital horn of the lateral ventricle. Histological, immunohistochemical and electron microscopic findings were consistent with high-grade ependymoma. Especially striking was the presence of bizzare pleomorphic giant cells which predominated in the tumor tissue. As a result the diagnosis of GCE was established. This type of neoplasm necessitates, at least in theory, differentiation with anaplastic oligodendroglioma, clear cell ependymoma, pleomorphic xanthoastrocytoma, giant cell glioblastoma, and subependymal giant cell astrocytoma. To date giant cell ependymomas (GCEs) were reported in seven cases in the literature. To the best of our knowledge this is the 8th case in the literature. In spite of apparently "worrisome" histology GCE seems to be a neoplasm with a relatively good prognosis. PMID:18006220

Adamek, Dariusz; Dec, Malgorzata; Sobol, Grazyna; Urbanowicz, Barbara; Jaworski, Marian

2008-02-01

408

Hepatitis B Antigen in Viral Hepatitis in West London  

Microsoft Academic Search

During the first 12 months of a total population survey 249 patients were seen with viral hepatitis. A total of 215 of these were tested for hepatitis B antigen (HB Ag) by radioimmunoassay and 32 (15%) were positive.More than five times as many men (27) as women (5) were HBAg positive and 19 of the men were between the ages

L. J. Farrow; S. G. Lamb; N. F. Coghill; R. L. Lindon; Jill Preece; A. J. Zuckerman; J. S. Stewart

1974-01-01

409

Immunology of hepatitis B virus and hepatitis C virus infection  

Microsoft Academic Search

More than 500 million people worldwide are persistently infected with the hepatitis B virus (HBV) and\\/or hepatitis C virus (HCV) and are at risk of developing chronic liver disease, cirrhosis and hepatocellular carcinoma. Despite many common features in the pathogenesis of HBV- and HCV-related liver disease, these viruses markedly differ in their virological properties and in their immune escape and

Michelina Nascimbeni; Barbara Rehermann

2005-01-01

410

Separating gas-giant and ice-giant planets by halting pebble accretion  

E-print Network

In the Solar System giant planets come in two flavours: 'gas giants' (Jupiter and Saturn) with massive gas envelopes and 'ice giants' (Uranus and Neptune) with much thinner envelopes around their cores. It is poorly understood how these two classes of planets formed. High solid accretion rates, necessary to form the cores of giant planets within the life-time of protoplanetary discs, heat the envelope and prevent rapid gas contraction onto the core, unless accretion is halted. We find that, in fact, accretion of pebbles (~ cm-sized particles) is self-limiting: when a core becomes massive enough it carves a gap in the pebble disc. This halt in pebble accretion subsequently triggers the rapid collapse of the super-critical gas envelope. As opposed to gas giants, ice giants do not reach this threshold mass and can only bind low-mass envelopes that are highly enriched by water vapour from sublimated icy pebbles. This offers an explanation for the compositional difference between gas giants and ice giants in the S...

Lambrechts, Michiel; Morbidelli, Alessandro

2014-01-01

411

Polymorphic tetranucleotide microsatellites for Cope's giant salamander ( Dicamptodon copei ) and Pacific giant salamander ( Dicamptodon tenebrosus )  

Microsoft Academic Search

We present primers and amplification conditions for 15 microsatellite loci developed for the Cope's giant salamander (Dicamptodon copei), 14 of which are tetranucleotide repeats. Cross-species amplification revealed 10 of these loci to also be polymorphic in the Pacific giant salamander (Dicamptodon tenebrosus). Several loci produced nonoverlapping allelic ranges between the two species and may be useful in species identification. These

C. A. STEELE; J. BAUMSTEIGER; A. STORFER

2008-01-01

412

Electrodynamics on extrasolar giant planets  

E-print Network

Strong ionization on close-in extrasolar giant planets suggests that their atmospheres may be affected by ion drag and resistive heating arising from wind-driven electrodynamics. Recent models of ion drag on these planets, however, are based on thermal ionization only and do not include the upper atmosphere above the 1 mbar level. These models are also based on simplified equations of resistive MHD that are not always valid in extrasolar planet atmospheres. We show that photoionization dominates over thermal ionization over much of the dayside atmosphere above the 100 mbar level, creating an upper ionosphere dominated by ionization of H and He and a lower ionosphere dominated by ionization of metals such as Na, K, and Mg. The resulting dayside electron densities on close-in exoplanets are higher than those encountered in any planetary ionosphere of the solar system, and the conductivities are comparable to the chromosphere of the Sun. Based on these results and assumed magnetic fields, we constrain the conduc...

Koskinen, T T; Lavvas, P; Cho, J Y-K

2014-01-01

413

Obscurin: a multitasking muscle giant.  

PubMed

Obscurin (approximately 800 kDa) is the third member of a family of giant proteins expressed in vertebrate striated muscle, along with titin (3-3.7 MDa) and nebulin (approximately 800 kDa). Like its predecessors, it is a multidomain protein composed of tandem adhesion modules and signaling domains. Unlike titin and nebulin, which are integral components of sarcomeres, obscurin is concentrated at the peripheries of Z-disks and M-lines, where it is appropriately positioned to communicate with the surrounding myoplasm. This unique distribution allows obscurin to bind small ankyrin 1, an integral component of the sarcoplasmic reticulum (SR) membrane. Obscurin also associates with the contractile apparatus through its binding to titin, sarcomeric myosin and perhaps other proteins of the contractile apparatus. Overexpression of the COOH-terminus of obscurin in primary myotubes has a dramatic and specific effect on the organization of sarcomeric myosin, indicating a role in the organization and regular assembly of A-bands. Given its ability to associate tightly, selectively and periodically with the periphery of the myofibril, its high affinity for an integral membrane protein of the SR and its close association with thick filaments, we speculate that obscurin is ideally suited to play key roles in modulating the organization and assembly of both the myofibril and the SR. PMID:16625317

Kontrogianni-Konstantopoulos, Aikaterini; Bloch, Robert J

2005-01-01

414

Red Giant Plunging Through Space  

NASA Technical Reports Server (NTRS)

[figure removed for brevity, see original site] Poster Version

This image from NASA's Spitzer Space Telescope (left panel) shows the 'bow shock' of a dying star named R Hydrae, or R Hya, in the constellation Hydra.

Bow shocks are formed where the stellar wind from a star are pushed into a bow shape (illustration, right panel) as the star plunges through the gas and dust between stars. Our own Sun has a bow shock, but prior to this image one had never been observed around this particular class of red giant star.

R Hya moves through space at approximately 50 kilometers per second. As it does so, it discharges dust and gas into space. Because the star is relatively cool, that ejecta quickly assumes a solid state and collides with the interstellar medium. The resulting dusty nebula is invisible to the naked eye but can be detected using an infrared telescope. This bow shock is 16,295 astronomical units from the star to the apex and 6,188 astronomical units thick (an astronomical unit is the distance between the sun and Earth). The mass of the bow shock is about 400 times the mass of the Earth.

The false-color Spitzer image shows infrared emissions at 70 microns. Brighter colors represent greater intensities of infrared light at that wavelength. The location of the star itself is drawn onto the picture in the black 'unobserved' region in the center.

2006-01-01

415

Giant resonances of endohedral atoms  

E-print Network

We demonstrate for the first time that the effect of fullerene shell upon photoionization of the "caged" atom in an endohedral can result in formation of Giant Endohedral Resonances or GER. This is illustrated by the concrete case of Xe@C60 photoionization cross-section that exhibits at 17 eV a powerful resonance with total oscillator strengths of about 25. The prominent modification of the 5p6 electron photoionization cross-section of Xe@C60 takes place due to strong fullerene shell polarization under the action of the incoming electromagnetic wave and oscillation of this cross-section due to the reflection of the photoelectron from Xe by the C60. These two factors transform the smoothly decreasing 5p6 cross-section of Xe into a rather complex curve with a powerful maximum for Xe@C60, with the oscillator strength being equal to 25! The polarization of C60 is expressed via its total photoabsorption cross-section. The reflection of the photoelectron is taken into account in the frame of the so-called bubble po...

Amusia, M Ya; Chernysheva, L V

2007-01-01

416

Giant electrocaloric effect around Tc.  

PubMed

We use molecular dynamics with a first-principles-based shell model potential to study the electrocaloric effect (ECE) in lithium niobate, LiNbO(3), and find a giant electrocaloric effect along a line passing through the ferroelectric transition. With an applied electric field, a line of maximum ECE passes through the zero field ferroelectric transition, continuing along a Widom line at high temperatures with increasing fields, and along the instability that leads to homogeneous ferroelectric switching below T(c) with an applied field antiparallel to the spontaneous polarization. This line is defined as the minimum in the inverse capacitance under an applied electric field. We investigate the effects of pressure, temperature and an applied electric field on the ECE. The behavior we observe in LiNbO(3) should generally apply to ferroelectrics; we therefore suggest that the operating temperature for refrigeration and energy scavenging applications should be above the ferroelectric transition region to obtain a large electrocaloric response. The relationship between T(c), the Widom line, and homogeneous switching should be universal among ferroelectrics, relaxors, multiferroics, and the same behavior should be found under applied magnetic fields in ferromagnets. PMID:23215332

Rose, Maimon C; Cohen, R E

2012-11-01

417

[Hepatitis B and pregnancy].  

PubMed

In pregnant women, hepatitis B virus (HBV) infection presents the risk of mother-to-child (vertical) transmission. The contaminated newborn most often remains a chronic carrier. Mother-to-child transmission can be avoided by serovaccination of the newborn. Screening for HBs antigen is essential in all pregnant women; in France, it is mandatory at the 6-month prenatal examination. All infants born to mothers who are carriers of HBs antigen must receive a serovaccination against this virus, by intramuscular injection of vaccine and of hepatitis B immune globulin (H-BIG, 100 or 200 IU), in two different sites, in the first hours after birth. Vaccination then continues, according to the recommended protocol. Although the combination of vaccination and H-BIG is very effective in preventing chronic carriage in children (efficacy >90 %), some children may nonetheless be contaminated, especially when the viral load is very high during pregnancy. These women with very high viral loads may receive lamivudine treatment at the end of pregnancy to diminish viral load and thus the risk of chronic carriage in the child; however the role of this drug in this situation is not yet clearly defined. The efficacy of the serovaccination must be confirmed in all children by a serologic examination (HBs antigen and anti-HBs antibodies) at some time after the last vaccination. Children carrying the HBs antigen must be seen by a pediatrician who has experience with viral hepatitis. When HBs antigen is found in a woman during pregnancy, a specialist should be consulted and the family should undergo complete serologic testing (HBs antigen, anti-HBc and anti-HBs antibodies). PMID:18662605

Bacq, Y

2008-01-01

418

K & M giants equivalent widths (Aoki+ 1997)  

NASA Astrophysics Data System (ADS)

The analyses of high resolution infrared spectra have been done for CN lines in oxygen-rich cool evolved stars including 2 K giants, 20 M giants and 1 S-type star. Since CN lines analyzed in the present work are weak and resolved well, they are appropriate for quantitative analyses. CN lines of {DELTA}v=-2 and -1 sequences (red system) which are in the K- and the H-window regions, respectively, give the consistent nitrogen abundance for each star. The analyses of NH lines in the L-window region have been done for 5 late M giants for which CN lines have been also analyzed. Although the triplet structure of NH lines cannot be fully resolved, they are preferable because determination of nitrogen abundance is almost independent of other elemental abundances while nitrogen abundance based on CN depends on carbon abundance. The nitrogen abundances derived from NH for late M giants agree well with those from CN for which we adopt 7.75eV as the dissociation energy in the analysis. The results show that the nitrogen abundances in late M giants are larger than those in early M giants while decrease of the carbon abundance was found in late M giants by our previous work (Tsuji, 1991A&A...245..203T). These variations of abundances can not be explained by the first dredge-up model but require additional processing by the CN cycle and mixing after the first dredge-up. However, there is no obvious evidence of other processes such as the 3?-process and subsequent hot bottom burning in our program stars. Such variation of the carbon and nitrogen abundances is not well understood by the present evolutionary models of low-mass and intermediate-mass stars. (3 data files).

Aoki, W.; Tsuji, T.

1997-09-01

419

Osteoclastic giant cell tumor of the pancreas?  

PubMed Central

INTRODUCTION Pancreatic giant cell tumors are rare, with an incidence of less than 1% of all pancreatic tumors. Osteoclastic giant cell tumor (OGCT) of the pancreas is one of the three types of PGCT, which are now classified as undifferentiated carcinoma with osteoclast-like giant cells. PRESENTATION OF CASE The patient is a 57 year old woman who presented with a 3 week history of epigastric pain and a palpable abdominal mass. Imaging studies revealed an 18 cm × 15 cm soft tissue mass with cystic components which involved the pancreas, stomach and spleen. Exploratory laparotomy with distal pancreatectomy, partial gastrectomy and splenectomy was performed. Histology revealed undifferentiated pancreatic carcinoma with osteoclast-like giant cells with production of osteoid and glandular elements. DISCUSSION OGCT of the pancreas resembles benign-appearing giant cell tumors of bone, and contain osteoclastic-like multinucleated cells and mononuclear cells. OGCTs display a less aggressive course with slow metastasis and lymph node spread compared to pancreatic adenocarcinoma. Due to the rarity of the cancer, there is a lack of prospective studies on treatment options. Surgical en-bloc resection is currently considered first line treatment. The role of adjuvant therapy with radiotherapy or chemotherapy has not been established. CONCLUSION Pancreatic giant cell tumors are rare pancreatic neoplasms with unique clinical and pathological characteristics. Osteoclastic giant cell tumors are the most favorable sub-type. Surgical en bloc resection is the first line treatment. Long-term follow-up of patients with these tumors is essential to compile a body of literature to help guide treatment. PMID:24631915

Temesgen, Wudneh M.; Wachtel, Mitchell; Dissanaike, Sharmila

2014-01-01

420

Propranolol in Use for Treatment of Complex Infant Hemangiomas: Literature Review Regarding Current Guidelines for Preassessment and Standards of Care before Initiation of Therapy  

PubMed Central

In 2008, the positive effects of propranolol on infantile hemangiomas (IH) have been discovered serendipitously by Léauté-Labrèze and her coworkers. Since then, propranolol has been in use in allday clinical practice worldwide for treatment of IH. It even caused some kind of paradigm shift in the overall management of these lesions, though propranolol is still not FDA approved, respectively, in “off-label” use for this indication in the majority of institutions. Thus, the aim of this communication is to evaluate the literature for current evidence regarding guidelines for preassessment and standards of care before initiation of therapy. PMID:23766715

Fette, Andreas

2013-01-01

421

Hepatitis B Virus Infection and Hepatocellular Carcinoma: Correlation between IgM Antibody to Hepatitis B Core Antigen, Hepatitis B e Antigen, and Hepatitis B DNA.  

National Technical Information Service (NTIS)

Sera from 102 black patients with primary hepatocellular carcinoma (PHC) and hepatitis B surface antigenemia were tested for immunoglobulin M antibody against hepatitis B core (IgM anti-HBc), hepatitis B e antigen (HBeAg), and hepatitis B viral (HBV) DNA....

E. Song, G. M. Dusheiko, M. C. Kew, M. H. Sjogren

1988-01-01

422

5 Natural history of hepatitis C  

Microsoft Academic Search

SUMMARY Hepatitis B virus (HBV) infection can cause acute, fulminant or chronic hepatitis, liver cirrhosis and hepatocellular carcinoma (HCC). Perinatally or childhood acquired HBV infection usually causes subclinical or anicteric acute hepatitis and is associated with a high risk of chronicity (30 to 90% of cases), whereas adult acquired infection may cause acute symptomatic hepatitis (approximately 30% of patients) and

Leonard B. Seeff

2000-01-01

423

An MHD Model for Magnetar Giant Flares  

NASA Astrophysics Data System (ADS)

Giant flares on soft gamma-ray repeaters that are thought to take place on magnetars release enormous energy in a short time interval. Their power can be explained by catastrophic instabilities occurring in the magnetic field configuration and the subsequent magnetic reconnection. By analogy with the coronal mass ejection events on the Sun, we develop a theoretical model via an analytic approach for magnetar giant flares. In this model, the rotation and/or displacement of the crust causes the field to twist and deform, leading to flux rope formation in the magnetosphere and energy accumulation in the related configuration. When the energy and helicity stored in the configuration reach a threshold, the system loses its equilibrium, the flux rope is ejected outward in a catastrophic way, and magnetic reconnection helps the catastrophe develop to a plausible eruption. By taking SGR 1806-20 as an example, we calculate the free magnetic energy released in such an eruptive process and find that it is more than 1047 erg, which is enough to power a giant flare. The released free magnetic energy is converted into radiative energy, kinetic energy, and gravitational energy of the flux rope. We calculated the light curves of the eruptive processes for the giant flares of SGR 1806-20, SGR 0526-66, and SGR 1900+14, and compared them with the observational data. The calculated light curves are in good agreement with the observed light curves of giant flares.

Meng, Y.; Lin, J.; Zhang, L.; Reeves, K. K.; Zhang, Q. S.; Yuan, F.

2014-04-01

424

Electrodynamics on Extrasolar Giant Planets  

NASA Astrophysics Data System (ADS)

Strong ionization on close-in extrasolar giant planets (EGPs) suggests that their atmospheres may be affected by ion drag and resistive heating arising from wind-driven electrodynamics. Recent models of ion drag on these planets, however, are based on thermal ionization only and do not include the upper atmosphere above the 1 mbar level. These models are also based on simplified equations of resistive magnetohydrodynamics that are not always valid in extrasolar planet atmospheres. We show that photoionization dominates over thermal ionization over much of the dayside atmosphere above the 100 mbar level, creating an upper ionosphere dominated by ionization of H and He and a lower ionosphere dominated by ionization of metals such as Na, K, and Mg. The resulting dayside electron densities on close-in exoplanets are higher than those encountered in any planetary ionosphere of the solar system, and the conductivities are comparable to the chromosphere of the Sun. Based on these results and assumed magnetic fields, we constrain the conductivity regimes on close-in EGPs and use a generalized Ohm's law to study the basic effects of electrodynamics in their atmospheres. We find that ion drag is important above the 10 mbar level where it can also significantly alter the energy balance through resistive heating. Due to frequent collisions of the electrons and ions with the neutral atmosphere, however, ion drag is largely negligible in the lower atmosphere below the 10 mbar level for a reasonable range of planetary magnetic moments. We find that the atmospheric conductivity decreases by several orders of magnitude in the night side of tidally locked planets, leading to a potentially interesting large-scale dichotomy in electrodynamics between the day and night sides. A combined approach that relies on UV observations of the upper atmosphere, phase curve and Doppler measurements of global dynamics, and visual transit observations to probe the alkali metals can potentially be used to constrain electrodynamics in the future.

Koskinen, T. T.; Yelle, R. V.; Lavvas, P.; Y-K. Cho, J.

2014-11-01

425

A Giant Sample of Giant Pulses from the Crab Pulsar  

NASA Astrophysics Data System (ADS)

We observed the Crab pulsar with the 43 m telescope in Green Bank, WV over a timespan of 15 months. In total we obtained 100 hr of data at 1.2 GHz and seven hours at 330 MHz, resulting in a sample of about 95,000 giant pulses (GPs). This is the largest sample, to date, of GPs from the Crab pulsar taken with the same telescope and backend and analyzed as one data set. We calculated power-law fits to amplitude distributions for main pulse (MP) and interpulse (IP) GPs, resulting in indices in the range of 2.1-3.1 for MP GPs at 1.2 GHz and in the range of 2.5-3.0 and 2.4-3.1 for MP and IP GPs at 330 MHz. We also correlated the GPs at 1.2 GHz with GPs from the Robert C. Byrd Green Bank Telescope (GBT), which were obtained simultaneously at a higher frequency (8.9 GHz) over a span of 26 hr. In total, 7933 GPs from the 43 m telescope at 1.2 GHz and 39,900 GPs from the GBT were recorded during these contemporaneous observations. At 1.2 GHz, 236 (3%) MP GPs and 23 (5%) IP GPs were detected at 8.9 GHz, both with zero chance probability. Another 15 (4%) low-frequency IP GPs were detected within one spin period of high-frequency IP GPs, with a chance probability of 9%. This indicates that the emission processes at high and low radio frequencies are related, despite significant pulse profile shape differences. The 43 m GPs were also correlated with Fermi ?-ray photons to see if increased pair production in the magnetosphere is the mechanism responsible for GP emission. A total of 92,022 GPs and 393 ?-ray photons were used in this correlation analysis. No significant correlations were found between GPs and ?-ray photons. This indicates that increased pair production in the magnetosphere is likely not the dominant cause of GPs. Possible methods of GP production may be increased coherence of synchrotron emission or changes in beaming direction.

Mickaliger, M. B.; McLaughlin, M. A.; Lorimer, D. R.; Langston, G. I.; Bilous, A. V.; Kondratiev, V. I.; Lyutikov, M.; Ransom, S. M.; Palliyaguru, N.

2012-11-01

426

Polymyalgia Rheumatica and Giant Cell (Temporal) Arteritis (Beyond the Basics)  

MedlinePLUS

... cell (temporal) arteritis Management and outcome of thoracic aortic aneurysm Patient information: Polymyalgia rheumatica and giant cell arteritis ( ... Patient information Polymyalgia rheumatica Temporal artery biopsy Thoracic aortic ... Patient information: Polymyalgia rheumatica and giant cell ( ...

427

OBSERVATION OF INDIGENOUS POLYCYCLIC AROMATIC HYDROCARBONS IN `GIANT' CARBONACEOUS ANTARCTIC  

E-print Network

. No evidence of contamination whilst in the Antarctic environment could be found. The dramatic variationOBSERVATION OF INDIGENOUS POLYCYCLIC AROMATIC HYDROCARBONS IN `GIANT' CARBONACEOUS ANTARCTIC aromatic hydrocarbons (PAHs) in fragments of fifteen `giant' (200 m) carbonaceous Antarctic micrometeorites

Zare, Richard N.

428

A Giant Unruptured Right Coronary Sinus of Valsalva Aneurysm  

PubMed Central

There have been few case reports on giant sinus of Valsalva aneurysm (SVA). We report a case of a giant unruptured right coronary SVA that was confused with a pericardial cyst by transthoracic echocardiography. PMID:22509442

Huh, Seok-Jae; Lee, Dong-Yeol; Kang, Hyojin; Kim, Bo-Sung; Cho, Yong-Rack; Kim, Moo-Hyun; Kim, Young-Dae; Lee, Sun-Mi

2012-01-01

429

Scanning electron microscopy in nematode-induced giant transfer cells.  

PubMed

A study of giant cells induced by the root-knot nematode, Meloidogyne incognita, in roots of Impatiens balsamina was made by scanning electron microscopy. The cytoplasmic contents of giant cells were removed by a procedure based on KOH digestion, to reveal inner wall structure. Wall ingrowths typical of transfer cells are present in giant cells from six days onwards after induction. They develop on walls adjacent to vascular tissues, and their distribution and development was examined. Pit fields contianing plasmodesmata become elaborated in walls between giant cells, but pit fields are lost between giant cells and cells outside them. The distribution of plasmodesmata in pit fields suggests that de novo formation of plasmodesmata occurs in walls between giant cells. Various aspects of giant cell formation and function are discussed and wall ingrowth development is compared in giant cells and normal transfer cells. PMID:1001022

Jones, M G; Dropkin, V H

1976-01-01

430

They Might Be Giants: Using Kepler Data to Classify the Evolutionary State of Red Giant Stars  

NASA Astrophysics Data System (ADS)

Utilizing Kepler long cadence data from quarters 4 through 11, a blind study was performed of the long period (>1 day) variability of 200 giant stars previously identified as hydrogen shell burning (Red Giant Branch - RGB) giants or helium core burning (Red Clump) giants by the Bedding et al. (2011) asteroseismology study. By focusing on periods between 1 and 30 days, a relationship was found between the amplitude of the strongest period and the red giant evolutionary state. A second blind test using this diagnostic was able to correctly predict the evolutionary state of the red giants -RGB or Red Clump - with 74% accuracy. The goal was to find a diagnostic that would allow for ground based differentiation, but the typical amplitudes were less than 0.5 mmag. Understanding this difference may lead to better understanding of the red giant evolutionary process. This research made use of the NASA Exoplanet Archive and was made possible through the NASA/IPAC Training in Archival Research Project (NITARP), funded by NASA Astrophysics Data Program and Archive Outreach funds.

Miller, Danielle; Bensel, H.; Donelson, F.; Seebode, S.; Ciardi, D. R.; Howell, S. B.; Da, R.; Figueroa, A.; Grgurich, A.; Holliday, C.; Harrison, D.; Keiser, E.; Kung, S.; Merickel, E.; Quinones, Z.; Stegner, L.; Vicente, S.; Wang, E.; Warner, E.; We, I.; Yanai, K.

2014-01-01

431

Oligarchic and giant impact growth of terrestrial planets in the presence of gas giant planet migration  

E-print Network

We present the results of N--body simulations which examine the effect that gas giant planet migration has on the formation of terrestrial planets. The models incorporate a 0.5 Jupiter mass planet undergoing type II migration through an inner protoplanet--planetesimal disk, with gas drag included. Each model is initiated with the inner disk being at successively increased levels of maturity, so that it is undergoing either oligarchic or giant impact style growth as the gas giant migrates. In all cases, a large fraction of the disk mass survives the passage of the giant, either by accreting into massive terrestrial planets shepherded inward of the giant, or by being scattered into external orbits. Shepherding is favored in younger disks where there is strong dynamical friction from planetesimals and gas drag is more influential, whereas scattering dominates in more mature disks where dissipation is weaker. In each scenario, sufficient mass is scattered outward to provide for the eventual accretion of a set of terrestrial planets in external orbits, including within the system's habitable zone. An interesting result is the generation of massive, short period, terrestrial planets from compacted material pushed ahead of the giant. These planets are reminiscent of the short period Neptune mass planets discovered recently, suggesting that such `hot Neptunes' could form locally as a by-product of giant planet migration.

Martyn J. Fogg; Richard P. Nelson

2005-07-07

432

Aplastica Anemia And Viral Hepatitis  

PubMed Central

Acquired aplastic anemia (aAA) is a severe and rare disease, characterized by hematopoietic bone marrow failure and peripheral cytopenia. The pathophysiology is immune mediated in most cases, activated T1 lymphocytes have been identified as effector cells. The disease can be successfully treated with combined immunosuppressive therapy or allogeneic hematopoietic stem cell transplantation. Hepatitis-associated aplastic anemia (HAA) is a syndrome of bone marrow failure following the development of acute seronegative hepatitis. HAA syndrome most often affects young males who presented severe pancytopenia two to three months after an episode of acute hepatitis. The clinical course of hepatitis is more frequently benign but a fulminant severe course is also described. The bone marrow failure can be explosive and severe and it is usually fatal if untreated, no correlations have been observed between severity of hepatitis and AA. In none of the studies a specific virus could be identified and most cases are seronegative for known hepatitis viruses. The clinical characteristics and response to immunotherapy indicate a central role for immune-mediated mechanism in the pathogenesis of HAA. The initial target organ of the immune response is the liver as suggested by the time interval between hepatitis and the onset of bone marrow failure. Liver histology is characterized by T cell infiltrating the parenchyma as reported in acute hepatitis. Recently in HAA it has been demonstrated intrahepatic and blood lymphocytes with T cell repertoire similar to that of confirmed viral acute hepatitis. The expanded T cell clones return to a normal distribution after response to immunosuppressive treatment, suggesting the antigen or T cell clearance. Therapeutic options are the same as acquired aplastic anemia. PMID:21415960

Cudillo, Laura

2009-01-01

433

Lithium and chromospherically active single giants  

NASA Technical Reports Server (NTRS)

Nine chromospherically active single K giants were identified from surveys of chromospherically active stars. The stars have v sin i's ranging from 6 to 46 km/sec. Such large velocities are not explained by scenarios of main sequence to giant star evolution. Fluxes of the ultraviolet emission lines of these stars are substantially less than those of FK Comae. Many of these giants have a moderate or strong lithium line strongly suggesting that these stars recently evolved from rapidly rotating A or early F stars as is suggested by their space motions. Thus, they are not spun down FK Com stars. The characteristics of these stars are such that they may be confused with pre-main sequence stars. The primary difference may be that the post main sequence stars have strong H alpha absorption lines while the pre-main sequence stars appear to have a weak H alpha absorption line or possibly H alpha in emission above the continuum.

Fekel, Francis C.

1988-01-01

434

Half-BPS giants, free fermions and microstates of superstars  

Microsoft Academic Search

We consider 1\\/2-BPS states in AdS\\/CFT. Using the matrix model description of chiral primaries explicit mappings among configurations of fermions, giant gravitons and the dual-giant gravitons are obtained. These maps lead to a `duality' between the giant and the dual-giant configurations which is the reflection of particle-hole duality of the fermion picture. These dualities give rise to some interesting consequences

Nemani V. Suryanarayana

2006-01-01

435

Giant planets around AF and M stars  

NASA Astrophysics Data System (ADS)

We present the results of two three-year surveys of young and nearby stars to search for wide orbit giant planets. On the one hand, we focus on early-type and massive, namely ? Pictoris analogs. On the other hand, we observe late type and very low mass stars, i.e., M dwarfs. We report individual detections of new planetary mass objects. According to our deep detection performances, we derive the observed frequency of giant planets between these two classes of parent stars. We find frequency between 6 to 12% but we are not able to assess a/no correlation with the host-mass.

Rameau, Julien; Chauvin, Gaël; Lagrange, Anne-Marie; Delorme, Philippe; Lannier, Justine

2014-01-01

436

Giant Lipoma of Posterior Cervical Region  

PubMed Central

Lipomas are the slow growing soft tissue tumors of benign nature. They commonly grow on torso and extremities but may also develop in head and neck region. Rarely lipomas can grow to acquire gigantic proportions, turning into an entity termed as giant lipoma. Such lipomas are entitled to immediate attention as they have a relatively high malignant potential. We report a rare case of giant cervical lipoma in an elderly gentleman, followed by a brief discussion on diagnosis and management of the disorder. PMID:25349767

Kumar, Lovekesh; Karande, Snehal K.; Kolhe, Yuvraj

2014-01-01

437

Isoscalar giant resonances in {sup 48}Ca  

SciTech Connect

The giant resonance region from 9.5 MeV < E{sub x} < 40 MeV in {sup 48}Ca has been studied with inelastic scattering of 240-MeV {alpha} particles at small angles, including 0 deg. 95{sub -15}{sup +11}% of E0 energy-weighted sum rule (EWSR), 83{sub -16}{sup +10}% of E2 EWSR, and 137 {+-} 20% of E1 EWSR were located below E{sub x}=40 MeV. A comparison of the experimental data with calculated results for the isoscalar giant monopole resonance, obtained within the mean-field-based random-phase approximation, is also given.

Lui, Y.-W.; Youngblood, D. H.; Shlomo, S.; Chen, X.; Tokimoto, Y.; Krishichayan,; Anders, M.; Button, J. [Cyclotron Institute, Texas A and M University, College Station, Texas 77843 (United States)

2011-04-15

438

Simultaneous Dual Frequency Observations of Giant Pulses  

NASA Astrophysics Data System (ADS)

Simultaneous data of Giant Pulses in the Crab Pulsar were taken at two widely spaced frequencies, using the detection of a giant pulse at 1.4 GHz at the VLA to trigger the observation of that same pulse period at 0.610 GHz at Green Bank. About 70% of these pulses are seen at both 1.4 and 0.6 GHz, implying they have a bandwidth of at least 0.8 GHz at 1 GHz. At both frequencies, the pulses are characterized by a fast rise and an exponential decay, consistent with scattering in the nebular filament zone only at 0.610 GHz.

Sallmen, S.; Backer, D. C.; Hankins, T.; Moffett, D.; Lundgren, S.

439

The interior structure of the giant planets  

NASA Astrophysics Data System (ADS)

An overview of the principal ideas and data pertaining to the construction of models of the interior structure of Jupiter, Saturn, Uranus, and Neptune is presented. Topics discussed include: the concept of Jupiter and Saturn as planets with hydrogenic crusts; the theory of the figure of rotating planets in hydrostatic equilibrium; a gas-liquid dynamic model of the giant planets; analysis of observational data; abundances of elements and groups of cosmochemical substances; equations of state; and the role of Jupiter in the formation of the earth and the giant planets.

Zharkov, V. N.

1991-12-01

440

Neglected Giant Scalp Basal Cell Carcinoma  

PubMed Central

Summary: Rarely, basal cell carcinoma grows to a giant size, invading the underlying deep tissue and complicating the treatment and reconstruction modalities. A giant basal cell carcinoma on the scalp is in some cases treated with a combination of surgery and radiation therapy, resulting in local control, a satisfactory long-term cosmetic and functional result. We present a case with a neglected basal cell scalp carcinoma, treated with wide excision and postoperative radiotherapy, reconstructed with a free latissimus dorsi flap. The cosmetic result is acceptable and there is no sign of recurrence 1 year postoperatively.

El-Charnoubi, Waseem-Asim Ghulam; Gehl, Julie; Krag, Christen

2014-01-01

441

Giant gigahertz optical activity in multiferroic ferroborate  

NASA Astrophysics Data System (ADS)

In contrast to the well-studied multiferroic manganites with a spiral structure, the electric polarization in multiferroic borates is induced within a collinear antiferromagnetic structure and can easily be switched by small static fields. Because of specific symmetry conditions, the static and dynamic properties in borates are directly connected, which leads to giant magnetoelectric and magnetodielectric effects. Here we prove experimentally that the giant magnetodielectric effect in samarium ferroborate, SmFe3(BO3)4, is of intrinsic origin and is caused by an unusually large electromagnon situated in the microwave range. This electromagnon reveals a strong optical activity exceeding 120 degrees of polarization rotation in a millimeter thick sample.

Kuzmenko, A. M.; Shuvaev, A.; Dziom, V.; Pimenov, Anna; Schiebl, M.; Mukhin, A. A.; Ivanov, V. Yu.; Bezmaternykh, L. N.; Pimenov, A.

2014-05-01

442

BPS Electromagnetic Waves on Giant Gravitons  

E-print Network

We find new 1/8-BPS giant graviton solutions in $AdS_5 \\times S^5$, carrying three angular momenta along $S^5$, and investigate their properties. Especially, we show that nonzero worldvolume gauge fields are admitted preserving supersymmetry. These gauge field modes can be viewed as electromagnetic waves along the compact D3 brane, whose Poynting vector contributes to the BPS angular momenta. We also analyze the (nearly-)spherical giant gravitons with worldvolume gauge fields in detail. Expressing the $S^3$ in Hopf fibration ($S^1$ fibred over $S^2$), the wave propagates along the $S^1$ fiber.

Seok Kim; Kimyeong Lee

2005-02-01

443

Towards the solution to the giant graviton puzzle  

Microsoft Academic Search

In this paper we present several ideas toward the solution to the giant graviton puzzle---the apparent multiplicity of supergravity states dual to field theory chiral primary operators. We use the fact that, for certain ranges of the angular momentum, giant gravitons can be mapped into vacua of a dual theory to argue that the sphere and AdS giant gravitons have

Iosif Bena; Douglas J. Smith

2005-01-01

444

MAPPING DIRECTLY IMAGED GIANT EXOPLANETS  

SciTech Connect

With the increasing number of directly imaged giant exoplanets, the current atmosphere models are often not capable of fully explaining the spectra and luminosity of the sources. A particularly challenging component of the atmosphere models is the formation and properties of condensate cloud layers, which fundamentally impact the energetics, opacity, and evolution of the planets. Here we present a suite of techniques that can be used to estimate the level of rotational modulations these planets may show. We propose that the time-resolved observations of such periodic photometric and spectroscopic variations of extrasolar planets due to their rotation can be used as a powerful tool to probe the heterogeneity of their optical surfaces. In this paper, we develop simulations to explore the capabilities of current and next-generation ground- and space-based instruments for this technique. We address and discuss the following questions: (1) what planet properties can be deduced from the light curve and/or spectra, and in particular can we determine rotation periods, spot coverage, spot colors, and spot spectra?; (2) what is the optimal configuration of instrument/wavelength/temporal sampling required for these measurements?; and (3) can principal component analysis be used to invert the light curve and deduce the surface map of the planet? Our simulations describe the expected spectral differences between homogeneous (clear or cloudy) and patchy atmospheres, outline the significance of the dominant absorption features of H{sub 2}O, CH{sub 4}, and CO, and provide a method to distinguish these two types of atmospheres. Assuming surfaces with and without clouds for most currently imaged planets the current models predict the largest variations in the J band. Simulated photometry from current and future instruments is used to estimate the level of detectable photometric variations. We conclude that future instruments will be able to recover not only the rotation periods, cloud cover, cloud colors, and spectra but even cloud evolution. We also show that a longitudinal map of the planet's atmosphere can be deduced from its disk-integrated light curves.

Kostov, Veselin [Department of Physics and Astronomy, Johns Hopkins University, 366 Bloomberg Center, 3400 North Charles Street, Baltimore, MD 21218 (United States)] [Department of Physics and Astronomy, Johns Hopkins University, 366 Bloomberg Center, 3400 North Charles Street, Baltimore, MD 21218 (United States); Apai, Daniel, E-mail: vkostov@pha.jhu.edu [Department of Astronomy, The University of Arizona, 933 North Cherry Avenue, Tucson, AZ 85718 (United States)] [Department of Astronomy, The University of Arizona, 933 North Cherry Avenue, Tucson, AZ 85718 (United States)

2013-01-01

445

Hepatic nervous system development.  

PubMed

During embryonic development, the liver emerges from the foregut as a thickening of the ventral endodermal epithelium. The embryonic liver then develops into a bud of cells that proliferates and differentiates to eventually form the largest gland of the body. Prior to birth, the primary function of the liver is hematopoietic, and the organ receives little innervation during early development. Postnatally, the role of the liver changes and many different nerve types modulate its function. Although the liver shares a common embryonic origin with other foregut derivatives, such as the gallbladder and the pancreas, the development of its innervation exhibits distinct characteristics. In this review, we summarize what is known about the development of the hepatic innervation, draw comparisons with the intrinsic innervation of the gastrointestinal tract and associated organs, and discuss the potential role of molecular signals in guiding the nerves that innervate the liver. PMID:15382016

Delalande, Jean-Marie; Milla, Peter J; Burns, Alan J

2004-09-01

446

Real-time ultrasonography as a monitoring technique for interstitial Nd:YAG laser treatment of voluminous hemangiomas and vascular malformations  

NASA Astrophysics Data System (ADS)

Voluminous vascular anomalies of the head and neck region are still treated with conventional surgery although Neodymium:Yttrium-Aluminum-Garnet (Nd:YAG) laser therapy is an effective treatment method. One hundred thirty give patients with voluminous hemangiomas and vascular malformations were treated with interstitial Nd:YAG laser therapy, partly complemented by a non-contact mode Nd:YAG laser light application. The vascular tumors had a diameter of more than 3 cm in two or all three dimensions. Treatment was carried out under ultrasound and manual control. Nearly 60% of the patients showed a complete clinical regression of the vascular tumor, a third of the patients had a partial regression and were satisfied with the treatment outcome. Four patients were treated unsuccessfully with the laser and three of them subsequently underwent conventional surgery. Only 10 patients showed cosmetic and functional deficits. These results on the interstitial Nd:YAG laser therapy of voluminous hemangiomas and vascular malformations in a large patient group demonstrated the high effectiveness of this novel and innovative therapy modality.

Werner, Jochen A.; Gottschlich, Stefan; Lippert, Burkard M.; Folz, Benedikt J.

1998-01-01

447

Pericholecystic hepatic activity in cholescintigraphy  

SciTech Connect

Gallbladder nonvisualization in cholescintigraphy has been shown to be a reliable finding in acute cholecystitis. In some cholescintigrams, the authors have observed faintly increased pericholecystic hepatic activity in conjunction with gallbladder nonvisualization. To determine the frequency and significance of the pericholecystic hepatic activity finding, they evaluated 334 consecutive adult patients who had cholescintigrams with technetium-99m diisopropylphenylcarboamoyl iminodiacetic acid. Pericholecystic hepatic activity was seen in 21% of the abnormal scans demonstrating gallbladder nonvisualization but in none of the other scans. Thirteen of these patients underwent surgery; 11 (85%) were found to have acute cholecystitis, and two (15%) had chronic cholecystitis. The pericholecystic hepatic activity sign is not specific for gangrenous cholecystitis or gallbladder perforation but does reliably indicate inflammatory gallbladder disease and is associated with a relatively high incidence of cholecystitis complicated by perforation.

Smith, R.; Rosen, J.M.; Gallo, L.N.; Alderson, P.O.

1985-09-01

448

Modeling Hepatitis C Treatment Policy.  

National Technical Information Service (NTIS)

Chronic infection with Hepatitis C virus (HCV) results in cirrhosis, liver cancer and death. As the nation's largest provider of care for HCV, US Veterans Health Administration (VHA) invests extensive resources in the diagnosis and treatment of the diseas...

D. Ross, G. Lambert, M. Chartier, M. A. Kuypers, P. D. Finley, R. J. Glass, T. W. Moore

2013-01-01

449

Hepatic Manifestations in Hematological Disorders  

PubMed Central

Liver involvement is often observed in several hematological disorders, resulting in abnormal liver function tests, abnormalities in liver imaging studies, or clinical symptoms presenting with hepatic manifestations. In hemolytic anemia, jaundice and hepatosplenomegaly are often seen mimicking liver diseases. In hematologic malignancies, malignant cells often infiltrate the liver and may demonstrate abnormal liver function test results accompanied by hepatosplenomegaly or formation of multiple nodules in the liver and/or spleen. These cases may further evolve into fulminant hepatic failure. PMID:23606974

Murakami, Jun

2013-01-01

450

Replication of hepatitis C virus  

Microsoft Academic Search

Exciting progress has recently been made in understanding the replication of hepatitis C virus, a major cause of chronic hepatitis, liver cirrhosis and hepatocellular carcinoma worldwide. The development of complete cell-culture systems should now enable the systematic dissection of the entire viral lifecycle, providing insights into the hitherto difficult-to-study early and late steps. These efforts have already translated into the

François Penin; Charles M. Rice; Darius Moradpour

2007-01-01