These are representative sample records from Science.gov related to your search topic.
For comprehensive and current results, perform a real-time search at Science.gov.
1

Scientists in Sport, the 2012-Inspired GlaxoSmithKline Schools Outreach Programme  

ERIC Educational Resources Information Center

The GlaxoSmithKline Scientists in Sport team have worked with 4science to provide resources and offer activities for use by schools to show the relevance of science in sport. Much of the content looks at anti-doping and the science involved with detecting the misuse of banned substances. Through the development of a website, this work can continue…

Gadd, Mark

2012-01-01

2

Mepolizumab: 240563, anti-IL-5 monoclonal antibody - GlaxoSmithKline, anti-interleukin-5 monoclonal antibody - GlaxoSmithKline, SB 240563.  

PubMed

Mepolizumab is an anti-interleukin-5 monoclonal antibody that is in clinical trials with GlaxoSmithKline (GSK) for the treatment of severe asthma, nasal polyposis and hypereosinophilic syndrome and eosinophilic oesophagitis (the latter two indications are classed as eosinophilia in the phase table). Interleukin-5 stimulates the production, activation and maturation of eosinophils. Since mepolizumab inhibits interleukin-5 and has a long terminal half-life, treatment with mepolizumab causes a sustained reduction in the numbers of circulating eosinophils. Thus, mepolizumab may be a useful therapeutic agent for the treatment of conditions characterized by increased levels of eosinophils. Hypereosinophilic syndrome is a rare idiopathic disease with broad clinical signs and symptoms that is diagnosed based on a persistent blood eosinophil count of >1500 cells, various end-organ damages (including skin, heart, lung, nervous system and digestive system), and with exclusion of known secondary causes of hypereosinophilia. Mepolizumab is in clinical trials for the treatment of hypereosinophilic syndrome, eosinophilc oesophagitis, severe asthma (in patients with airway eosinophilia) and nasal polyposis. GlaxoSmithKline (GSK) has completed enrolment in a phase II study of mepolizumab in 20 patients with symptomatic eosinophilic bronchitis with or without asthma in Canada. The randomized, double-blind, placebo-controlled study is evaluating the effects of intravenous mepolizumab on asthma control, airway eosinophilia and the degree to which concomitant corticosteroid treatment can be reduced (NCT00292877). In previous clinical studies, including trials in the EU and US, mepolizumab has shown a lack of effect on allergen-induced airway responses and inflammation despite a significant reduction in blood and sputum eosinophil levels.A randomized, double-blind, placebo-controlled, multicentre, phase III study of mepolizumab over 9 months in 85 patients with hypereosinophilic syndrome was completed in 2006. All patients have been offered, and continued in, a phase III, open-label, long-term extension study of mepolizumab. Enrolment in this study was completed in September 2006.A phase III, compassionate use trial of mepalizumab (NCT00244686) in patients with hypereosinophilic syndrome was ongoing in October 2007 in the US. Patients who have significant clinical disease but are unresponsive to traditional treatment and those who have demonstrated clinical benefit from previous anti-IL-5 treatment are eligible to take part in the trial. Mepolizumab received orphan drug status for first-line treatment in patients with hypereosinophilic syndrome in the US and the EU in 2004. Mepolizumab is also in phase I/II clinical development for the treatment of eosinophilic oesophagitis. A phase I/II trial (NCT00358449) began in August 2006 in the US, Australia, the UK and Canada, and will enrol approximately 72 paediatric patients with eosinophilic oesophagitis. The randomized, parallel-group clinical trial will evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of intravenous mepolizumab for 12 weeks. In September 2006, GSK completed enrolment in a phase I/II study of mepolizumab for the treatment of eosinophilic oesophagitis in ten adult patients in Switzerland (NCT00274703). The randomized, double-blind, placebo-controlled study will evaluate the pharmacokinetics, pharmacodynamics, safety and tolerability of IV mepolizumab.A phase I/II trial of mepolizumab in four patients with eosinophilic oesophagitis conducted by Cincinnati Children's hospital found the monoclonal antibody was safe and effective. Brigham and Women's Hospital in association with GSK is conducting a phase I/II trial of mepolizumab in patients with Churg-Strauss Syndrome (CSS) in the US. The trial, which started in September 2007, will evaluate the potential of mepolizumab to reduce the need for corticosteroid therapy in patients with CSS (NCT00527566). CSS, otherwise known as allergic granulomatosis, is defined by patients with asthma, eosinophilia and vascul

2008-01-01

3

SmithKline Beecham Biologicals Worldwide Vaccines  

NSDL National Science Digital Library

This new site from SmithKline Beecham, a "virtual gateway into the world of vaccinology," offers a host of resources on vaccination and vaccine preventable diseases. These resources are organized in three principle sections: Disease, Bio News, and Links. The first and largest section contains various reference resources for ten different diseases or disease groups, which are listed in four columns: disease, virus, epidemiology, and prevention. Although a public site, much of this information is aimed at physicians, health professionals, or other informed users. The Bio News section offers a selection of recent and archived scientific published data from peer-reviewed journals, a select list of links for breaking health news, and recent SmithKline Beecham vaccine press releases. A collection of related annotated links, sorted by country, rounds out the site. An additional site for registered medical professionals only is also available, and these users may log on via the public site. Please note that the site authors indicate that "This site is not intended for US audiences."

4

Our Client, GlaxoSmithKline is one of the world's leading research-based pharmaceutical companies. With 90000 employees world-wide, the company is  

E-print Network

are: Thrilled by mobile apps! Love to develop mobile applications for iOS and Android! Like and is looking for motivated professionals to join the team at the position of: Mobile applications developer You to experience new mobile development platforms! The role: Develops mobile applications for various GSK

Kasparian, Azniv

5

Better neutralization of herpes simplex virus type 1 (HSV-1) than HSV-2 by antibody from recipients of GlaxoSmithKline HSV-2 glycoprotein D2 subunit vaccine.  

PubMed

The Herpevac Trial evaluated a herpes simplex virus type 2 (HSV-2) glycoprotein D (gD2) subunit vaccine to prevent genital herpes. Unexpectedly, the vaccine protected against genital HSV-1 infection but not genital HSV-2 infection. We evaluated sera from 30 women seronegative for HSV-1 and HSV-2 who were immunized with gD2 in the Herpevac Trial. Neutralizing antibody titers to HSV-1 were 3.5-fold higher than those to HSV-2 (P < .001). HSV-2 gC2 and gE2 on the virus blocked neutralization by gD2 antibody, while HSV-1 gC1 and gE1 did not block neutralization by gD2 antibody. The higher neutralizing antibody titers to HSV-1 offer an explanation for the Herpevac results, and shielding neutralizing domains provides a potential mechanism. PMID:24652496

Awasthi, Sita; Belshe, Robert B; Friedman, Harvey M

2014-08-15

6

Scanner K-line photometry of Orion stars  

Microsoft Academic Search

Results are presented for two-channel scanner measurements of calcium K-line strengths in 39 Orion sword and belt stars. Values of the calcium k index and its associated standard error are given for each observed star, and the K-line strengths are compared with those of K-line standard stars and Hyades stars. Plots of k index against reddening-corrected color and of k-index

J. E. Hesser; W. McClintock; R. C. Henry

1977-01-01

7

Scanner K-line photometry of Orion stars  

NASA Technical Reports Server (NTRS)

Results are presented for two-channel scanner measurements of calcium K-line strengths in 39 Orion sword and belt stars. Values of the calcium k index and its associated standard error are given for each observed star, and the K-line strengths are compared with those of K-line standard stars and Hyades stars. Plots of k index against reddening-corrected color and of k-index deviation against metal-strength index deviation are provided which show that the Orion sword and belt stars do not differ significantly in their calcium and metal abundances from general field stars.

Hesser, J. E.; Mcclintock, W.; Henry, R. C.

1977-01-01

8

Quantifying the Impact of Prostate Volumes, Number of Biopsy Cores and 5 -Reductase Inhibitor Therapy on the  

E-print Network

and Department of Urology (MS, CGR), University of Texas Southwest Medical Center at Dallas and Dallas Urology at Charlotte (ZX), Charlotte and Urology Clinical Development and Medical Affairs Group, GlaxoSmithKline (RR

Serfling, Robert

9

Emerging Concepts of Pharmaceutical Research Funding  

E-print Network

Fischer German Ethics Council / MEZIS e.V. / BUKO Pharma Hamm 13:45 Jan Raaijmakers GlaxoSmithKline / Utrecht University / Top Institute Pharma Leiden, Netherlands 14:30 Coffee break 14:45 Panel discussion 15

Moeller, Ralf

10

78 FR 55263 - Draft Guidance for Industry on Bioequivalence Recommendations for Fluticasone Propionate...  

Federal Register 2010, 2011, 2012, 2013

...Xinafoate BE Recommendations). In December 2009, GlaxoSmithKline (GSK), manufacturer of the reference listed drug Advair Diskus...Salmeterol Xinafoate BE Recommendations before responding to GSK's citizen petition. This draft guidance is being issued...

2013-09-10

11

76 FR 6456 - Intent To Grant an Exclusive License for a U.S. Government-Owned Invention  

Federal Register 2010, 2011, 2012, 2013

...873, issued July 3, 2001, entitled ``Inactivated Dengue Virus Vaccine,'' for the field of use involving any prophylactic and/or therapeutic purified inactivated vaccine against Dengue virus for human use. The intended licensee is GlaxoSmithKline...

2011-02-04

12

Immunogenicity and safety of a meningococcal serogroup A, C, Y and W glycoconjugate vaccine, ACWY-TT.  

PubMed

A quadrivalent meningococcal serogroup A, C, W and Y conjugate vaccine (ACWY), utilising tetanus toxoid (TT) as its carrier protein (ACWY-TT; Nimenrix™, GlaxoSmithKline Vaccines, Rixensart, Belgium) has been demonstrated to be safe and immunogenic when administered to young children from 12 months of age, older children, adolescents, and adults. Administration of a single dose of ACWY-TT induces protective serum bactericidal antibodies against all four serogroups as well as good antibody persistence. Coadministration studies have demonstrated that ACWY-TT can be administered with diphtheria, tetanus, three-component acellular pertussis, hepatitis B, inactivated polio virus and Haemophilus influenzae type b conjugate vaccine (DTaP3-IPV-HBV/Hib, Infanrix™ hexa; GlaxoSmithKline Vaccines, Rixensart, Belgium); measles, mumps, rubella, varicella vaccine (Priorix-Tetra™; GlaxoSmithKline Vaccines, Rixensart, Belgium); 10-valent pneumococcal conjugate vaccine (Synflorix(®); GlaxoSmithKline Vaccines, Rixensart, Belgium); hepatitis A and B vaccine (Twinrix(®); GlaxoSmithKline Vaccines, Rixensart, Belgium); and seasonal influenza vaccine (Fluarix™; GlaxoSmithKline Vaccines, Rixensart, Belgium). Studies in young infants from 2 months of age have now commenced but immunisation with a single dose of ACWY-TT from 12 months of age is a safe and immunogenic option in the prevention of meningococcal disease. PMID:23712402

Findlow, Helen; Borrow, Ray

2013-05-01

13

The Impact of Juvenile Curfew Laws* Patrick Kline  

E-print Network

crimes committed by juveniles below the statutory curfew age. Curfews do not appear to be effectiveThe Impact of Juvenile Curfew Laws* Patrick Kline UC Berkeley / NBER pkline@econ.berkeley.edu First's youth curfews became a popular strategy for combating juvenile delinquency. A survey by Ruefle

Sadoulet, Elisabeth

14

Eddie Smith Dean E. Smith  

E-print Network

Daniels Hill Ackland McCaskill Paul Green Eddie Smith Alumni Center Carmichael Auditorium Center Student Dean E. Smith Student Hall Kenan Field House Bookstore Affairs Stadium Kenan Hill Williams House Forest

Whitton, Mary C.

15

Robert Smith.  

ERIC Educational Resources Information Center

Interviews Robert Smith, executive director of the International Association of Marriage and Family Counselors (IAMFC), a division of the American Counseling Association. He has been involved with the IAMFC from its beginning and is in a position to provide both a historical perspective and a vision of the division's future. (Author/MKA)

Pietrzak, Dale; L'Amoreaux, Nadene

1998-01-01

16

Stephen Jay Kline on systems, or physics, complex systems, and the gap between.  

SciTech Connect

At the end of his life, Stephen Jay Kline, longtime professor of mechanical engineering at Stanford University, completed a book on how to address complex systems. The title of the book is 'Conceptual Foundations of Multi-Disciplinary Thinking' (1995), but the topic of the book is systems. Kline first establishes certain limits that are characteristic of our conscious minds. Kline then establishes a complexity measure for systems and uses that complexity measure to develop a hierarchy of systems. Kline then argues that our minds, due to their characteristic limitations, are unable to model the complex systems in that hierarchy. Computers are of no help to us here. Our attempts at modeling these complex systems are based on the way we successfully model some simple systems, in particular, 'inert, naturally-occurring' objects and processes, such as what is the focus of physics. But complex systems overwhelm such attempts. As a result, the best we can do in working with these complex systems is to use a heuristic, what Kline calls the 'Guideline for Complex Systems.' Kline documents the problems that have developed due to 'oversimple' system models and from the inappropriate application of a system model from one domain to another. One prominent such problem is the Procrustean attempt to make the disciplines that deal with complex systems be 'physics-like.' Physics deals with simple systems, not complex ones, using Kline's complexity measure. The models that physics has developed are inappropriate for complex systems. Kline documents a number of the wasteful and dangerous fallacies of this type.

Campbell, Philip LaRoche

2011-06-01

17

ERP Modulation during Observation of Abstract Paintings by Franz Kline  

PubMed Central

The aim of this study was to test the involvement of sensorimotor cortical circuits during the beholding of the static consequences of hand gestures devoid of any meaning.In order to verify this hypothesis we performed an EEG experiment presenting to participants images of abstract works of art with marked traces of brushstrokes. The EEG data were analyzed by using Event Related Potentials (ERPs). We aimed to demonstrate a direct involvement of sensorimotor cortical circuits during the beholding of these selected works of abstract art. The stimuli consisted of three different abstract black and white paintings by Franz Kline. Results verified our experimental hypothesis showing the activation of premotor and motor cortical areas during stimuli observation. In addition, abstract works of art observation elicited the activation of reward-related orbitofrontal areas, and cognitive categorization-related prefrontal areas. The cortical sensorimotor activation is a fundamental neurophysiological demonstration of the direct involvement of the cortical motor system in perception of static meaningless images belonging to abstract art. These results support the role of embodied simulation of artist’s gestures in the perception of works of art. PMID:24130693

Sbriscia-Fioretti, Beatrice; Berchio, Cristina; Freedberg, David; Gallese, Vittorio; Umilta, Maria Alessandra

2013-01-01

18

Plasma Diagnostics Using K-Line Emission Profiles of Argon  

E-print Network

K-line profiles emitted from a warm dense plasma environment are used for diagnostics of Ar droplet plasmas created by high energy laser pulses. We observe temperature gradients within the Ar droplet from cold temperatures of the order of some 10 eV up to higher temperatures of about 170 eV. Non-perturbative wave functions are calculated as well as ionization energies, binding energies and relevant emission energies using a chemical {\\it ab initio} code. The plasma screening is considered within a perturbative approach to the Hamiltonian. The plasma effect influences the many-particle system resulting in energy shifts due to electron-ion and electron-electron interaction. With this approach we get a good reproduction of spectral features that are strongly influenced by ionization and excitation processes within the plasma. Comparing with the widely known FLYCHK code, counting for internal degrees of freedom (bound states) and treating pressure ionization within our quantum statistical approach leads to differ...

Chen, Yiling; Reinholz, Heidi; Röpke, Gerd

2014-01-01

19

Making British cortisone: Glaxo and the development of corticosteroids in Britain in the 1950s-1960s.  

PubMed

Following the announcement in 1949 in the USA that cortisone offered rheumatoid arthritis sufferers effective treatment for their crippling disease, the Ministry of Health came under considerable pressure from the medical profession and the public to make cortisone available in Britain. The Ministry, therefore, urged British companies to start manufacturing cortisone. Among the several pharmaceutical firms responding to the Ministry's request, Glaxo's expertise in the field of vitamins gave them a head start. This paper describes the varied and flexible strategy that enabled Glaxo to maintain this head start, and the scientific and technical capabilities which the company subsequently built up, enabling them to dominate the market for corticosteroids in Britain. Among the drugs to emerge out of the Glaxo project to manufacture cortisone, which began in 1950 and later became a wider R&D programme on steroids, was the topical steroid Betnovate, launched in 1963, which remains a best-seller today. However, although it led to successful new products, Glaxo's programme had limitations. The paper identifies a missed opportunity, in the shape of the biosynthetic route to steroid drugs, often considered as a milestone in the development of the new biotechnology. Whether or not this missed opportunity proved costly to the company is uncertain. However, it illustrates the role of technological path-dependence, and the importance of the integration between different scientific disciplines, in this case chemistry and biology, in pharmaceutical innovation. PMID:16337555

Quirke, Viviane

2005-12-01

20

Immunogenicity of Danish-SSI 1331 BCG vaccine in the UK: comparison with Glaxo-Evans 1077 BCG vaccine.  

PubMed

The immunogenicity and reactogenicity, in British schoolchildren, of the newly introduced Danish-SSI 1331 BCG vaccine was compared with that of the previously used Glaxo-Evans 1077 BCG vaccine. Interferon-gamma (IFN-gamma) response to M. tuberculosis purified protein derivative (M.tb PPD) in a 6-day whole blood assay and delayed type hypersensitivity (DTH) to tuberculin PPD were determined before and 1 year after receiving BCG or no vaccination. Scar size was measured 1 year after vaccination. There was no evidence of a difference in immunogenicity (IFN-gamma and DTH conversion rates) but evidence of lower reactogenicity (scar size) with Danish-SSI 1331 compared to Glaxo-Evans 1077 vaccines. PMID:16723176

Gorak-Stolinska, Patricia; Weir, Rosemary E; Floyd, Sian; Lalor, Maeve K; Stenson, Sally; Branson, Keith; Blitz, Rose; Luke, Sarah; Nazareth, Bernadette; Ben-Smith, Anne; Fine, Paul E M; Dockrell, Hazel M

2006-07-17

21

Consortium for Robotics and Unmanned Systems Education and Research Captain Jeff Kline, USN (ret)  

E-print Network

Consortium for Robotics and Unmanned Systems Education and Research Captain Jeff Kline, USN://www.facebook.com/CRUSER.CoI #12;Consortium for Robotics and Unmanned Systems Education and Research · From Technical and community of interest 2 #12;Consortium for Robotics and Unmanned Systems Education and Research

22

Consortium for Robotics and Unmanned Systems Education and Research Captain Jeff Kline, USN (ret)  

E-print Network

Consortium for Robotics and Unmanned Systems Education and Research Captain Jeff Kline, USN (ret) Director, CRUSER h8p://CRUSER.nps.edu #12;Consortium for Robotics and Unmanned;Consortium for Robotics and Unmanned Systems Education and Research Sponsor: SECNAV On Campus

23

Consortium for Robotics and Unmanned Systems Education and Research Captain Jeff Kline, USN (ret)  

E-print Network

Consortium for Robotics and Unmanned Systems Education and Research Captain Jeff Kline, USN (ret) Director, CRUSER http://www.nps.edu/Research/CRUSER #12;Consortium for Robotics and Unmanned Systems · Collaborative environment and community of interest 2 #12;Consortium for Robotics and Unmanned Systems Education

24

organisation a real edge  

E-print Network

a real edge in an increasingly competitive world. And, while there are many flow-on benefits, our-term strategic alliances with industry and end users to achieve positive outcomes. These include: Zoos Victoria, Victoria Police, FE Technologies and GlaxoSmithKline. Funding the way to success #12;Zoos Victoria

Albrecht, David

25

Modeling prostate cancer detection probability using prostate specific antigen, transition and peripheral zone  

E-print Network

@utdallas.edu. Website: www.utdallas.edu/serfling. 2 Department of Urology, University of Texas Southwest Medical Center from GlaxoSmithKline is gratefully acknowledged. 5 Department of Urology, University of Texas Southwest Medical Center at Dallas, 5323 Harry Nines Boulevard, Dallas, TX 75390-9110, USA. 6Department of Urology

Serfling, Robert

26

For personal use. Only reproduce with permission from Elsevier Ltd Perspectives  

E-print Network

on the reputation of a powerful and important industry come when some of the biggest pharma companies are limping-- half of global pharma sales occur in the USA--slowed, thanks largely to fewer blockbuster drug launchesZeneca and GlaxoSmithKline have been extraordinarily volatile. As big pharma feels the squeeze, it seems its chief

Colquhoun, David

27

Research Paper 232 Control of progenitor cell number by mitogen supply and demand  

E-print Network

controls for one well-defined population of neural Neuropharmacology, GlaxoSmithKline, New Frontiers]. This behavior is common to other types of embryonic precursors. Fora clear idea of how these controls, which neurogenesis [4]. Determining the cause of this dynamic cell cycle behavior will be crucial forof replicative

Richardson, William D.

28

Data sharing, year 1 - access to data from industry-sponsored clinical trials.  

PubMed

Since May 2013, researchers have been able to request access to deidentified patient-level data from GlaxoSmithKline-sponsored clinical trials, subject to oversight by an independent review panel. The initiative has been a productive first step in transparency. PMID:25317745

Strom, Brian L; Buyse, Marc; Hughes, John; Knoppers, Bartha M

2014-11-27

29

Cellular/Molecular KCNQ/M Currents in Sensory Neurons: Significance for  

E-print Network

Cellular/Molecular KCNQ/M Currents in Sensory Neurons: Significance for Pain Therapy Gayle MNeurological and Gastrointestinal Diseases Centre of Excellence for Drug Discovery, GlaxoSmithKline, Harlow CM SG1 2NY, United Kingdom Neuronal hyperexcitability is a feature of epilepsy and both inflammatory

Brown, David

30

Counseling pregnant women treated with paroxetine Concern about cardiac malformations  

Microsoft Academic Search

QUESTION I have always reassured my patients that taking selective serotonin reuptake inhibitors (SSRIs) during pregnancy would not increase their risk of having children with major malformations. A recent warning from Health Canada, based on results of a study from GlaxoSmithKline, stated that infants exposed to paroxetine might be at higher risk of congenital malformations, specifi cally cardiovascular defects. Some

Adrienne Einarson; Gideon Koren

31

Viruses as gene delivery vectors: Application to gene function, target validation, and assay development  

Microsoft Academic Search

A Biochemical Pharmacology Discussion Group Conference, was held at the headquarters of the New York Academy of Sciences on December 4, 2001 as part of an ongoing series designed to highlight and review areas important to modern drug development (Figure 1). Briefly introduced by Tom Kost (GlaxoSmithKline) and Michael Lotze (University of Pittsburgh), the focus was on the intersection of

Michael T Lotze; Thomas A Kost

2002-01-01

32

Evolutionary Computing in Data Mining A. Ghosh and L C. Jain (editors), pp211235, 2004 Springer.  

E-print Network

Exploration Sciences, GlaxoSmithKline, Research and Development, Greenford, Middlesex, UK. http://www.cs.ucl.ac­15 years. The discovery of new chemical entities with appropriate biological ac- tivity is a multi. More refined measurements of primary target binding/potency involve testing at a number of chemical

Fernandez, Thomas

33

Evolutionary Computing in Data Mining A. Ghosh and L C. Jain (editors), pp211{235, 2004 Springer.  

E-print Network

Exploration Sciences, GlaxoSmithKline, Research and Development, Greenford, Middlesex, UK. http://www.cs.ucl.ac in the region of 12{15 years. The discovery of new chemical entities with appropriate biological ac- tivity/EC50 and early selectivity assays. More re#12;ned measurements of primary target binding/potency

Fernandez, Thomas

34

hey answer only the questions they want to answer. They ignore evidence  

E-print Network

for adolescents in the United States. But doctors have now been warned off prescribing Paxil to youngsters, after evidence emerged that it increases the risk of suicidal behaviour. It was claimed in a court case brought in the United States that GlaxoSmithKline had sup- pressed data showing this since 1998. Rick Koenig

Cai, Long

35

Ecological Effects in Malaria Vaccine Effectiveness in  

E-print Network

Ecological Effects in Malaria Vaccine Effectiveness in Lilongwe, Malawi Cameron Taylor B component to a GlaxoSmithKline phase III trial vaccine trial so that researchers can better understand distribution and the ecological effects of both malaria transmission intensity and vaccine efficacy

Doyle, Martin

36

Improving Doctor/Caregiver Communication  

MedlinePLUS

... that are partnering with us in support of NFC Month 2005 andThe Caring Every Day Campaign. Caring ... HealthCare AstraZeneca Family Partners:Eisai Inc. Novartis Pfizer NFC Month Partners: Brooks and Eckerd Pharmacy GlaxoSmithKline Johnson & ...

37

Vanderbilt University 200 Smith Court  

E-print Network

John Smith Vanderbilt University 200 Smith Court Smithville, TN 37000 April 12, 20xx Ms. Janice-5000 or john.smithy.smith@vanderbilt.edu, and I thank you for your consideration. Sincerely, (Signature Here) John Smith #12;

Bordenstein, Seth

38

Genetic background of nonmutant Piebald-Virol-Glaxo rats does not influence nephronophthisis phenotypes  

PubMed Central

Background Nephronophthisis (NPHP), which affects multiple organs, is a hereditary cystic kidney disease (CKD), characterized by interstitial fibrosis and numerous fluid-filled cysts in the kidneys. It is caused by mutations in NPHP genes, which encode for ciliary proteins known as nephrocystins. The disorder affects many people across the world and leads to end-stage renal disease. The aim of this study was to determine if the genetic background of the nonmutant female Piebald-Virol-Glaxo (PVG/Seac–/–) rat influences phenotypic inheritance of NPHP from mutant male Lewis polycystic kidney rats. Methods Mating experiments were performed between mutant Lewis polycystic kidney male rats with CKD and nonmutant PVG and Wistar Kyoto female rats without cystic kidney disease to raise second filial and backcross 1 progeny, respectively. Rats that developed cystic kidneys were identified. Systolic blood pressure was determined in each rat at 12 weeks of age using the tail and cuff method. After euthanasia, blood samples were collected and chemistry was determined. Histological examination of the kidneys, pancreas, and liver of rats with and without cystic kidney disease was performed. Results It was established that the genetic background of nonmutant female PVG rats did not influence the phenotypic inheritance of the CKD from mutant male Lewis polycystic kidney rats. The disease arose as a result of a recessive mutation in a single gene (second filial generation, CKD = 13, non-CKD = 39, ?2 = 0.00, P ? 0.97; backcross 1 generation, CKD = 67, non-CKD = 72, ?2 = 0.18, P > 0.05) and inherited as NPHP. The rats with CKD developed larger fluid-filled cystic kidneys, higher systolic blood pressure, and anemia, but there were no extrarenal cysts and disease did not lead to early pup mortality. Conclusion The genetic background of the nonmutant PVG rats does not influence the genetic and phenotypic inheritance of CKD from mutant Lewis polycystic kidney rats. A single recessive mutation incapacitated the gene, which relaxed its functional constraints, and led to formation of multiple cysts in the kidneys of the homozygous mutant rats. PMID:23549608

Yengkopiong, Jada Pasquale; Lako, Joseph Daniel Wani

2013-01-01

39

Joseph Smith the Prophet  

NSDL National Science Digital Library

Just a quick look at the Prophet Joseph Smith\\'s life and all that he accomplished. As you go to the site below think of the following questions: What do you think was the greatest contribution the Prophet Joseph Smith made? What can you do today to show him your appreciation and to keep the work moving forward? Key Events in the Life of Joseph Smith While looking through the church sites ask yourself the following question: Which ...

Carter, Mr. S.

2006-10-23

40

David Smith Academic background  

E-print Network

David Smith Academic background Ph.D. in Mathematics (Algebra), Université de Sherbrooke, Canada project program (I. Assem, F. Bergeron, C. Reutenauer, D. Smith) $132,000 ($44,000 per year for 3 years. Schiffler and D. Smith, Friezes, strings and cluster variables, to appear in Glasgow Mathematcal Journal. 2

41

Joshua Smith Spring 2006  

E-print Network

Stormwater Utilities in Georgia Joshua Smith Spring 2006 #12;The UGA Land Use Clinic provides in Georgia Author: Joshua Smith Editor: Jamie Baker Roskie University of Georgia Land Use Clinic Spring 2006....................................................................................................10 #12;#12;1Stormwater Utilities in Georgia Stormwater Utilities in Georgia Joshua Smith Spring 2006

Rosemond, Amy Daum

42

Variability of Solar UV Irradiance Related to Bright Magnetic Features Observed in Call K-Line: Relationship between Lyman alpha and K-line Report for UARS funding agency  

NASA Technical Reports Server (NTRS)

In this report we comment on the relationship between the Lyman alpha and Calcium K-line emission from the Sun. We firstly examine resolved Lyman alpha images (from TRACE) and resolved K-line images. We find that the Lyman alpha emission is consistent with a linear dependence on the K-line emission. As this is in conflict with the analysis of Johannesson et al.(1995, 1998) we proceed by comparing the disk integrated Lyman alpha flux as a function of ratio between the disk integrated Mg II core and wing fluxes (Johannesson et al (1998) having previously found a linear dependence between this index and the BBSO K-line index). We find that a reasonably good fit can be obtained, however note the discrepancies which lead Johannesson et al to consider the square root relationship. We suggest an alternative interpretation of the discrepancy.

Zirin, Harold; Cameron, Robert

1999-01-01

43

Adam Smith and Isaac Newton  

Microsoft Academic Search

The commonly held view that Adam Smith patterned economics after Issac Newton's method is examined and dismissed. Both Smith and Newton's methods are explored and compared. Smith's method is shown to have differed significantly from Newton's--in spite of Smith's pronouncements to the contrary--for reasons best explained by considering the Scottish tradition. Finally, the significance of Smith's methodology for modern economics

Deborah A. Redman

1993-01-01

44

The Adam Smith Page  

NSDL National Science Digital Library

Edward J. Harpham, Associate Professor of Government and Political Economy at the University of Texas at Dallas, developed this new site to promote the study of the moral, political, and economic ideas of Adam Smith. Anyone with an interest in Smith's ideas will find numerous resources of interest. Perhaps the most useful are Harpham's updated lists of new and forthcoming scholarly articles and books on Smith. Students will also benefit from the comprehensive bibliography of secondary works, brief commentaries on Smith's works, and the collection of related links.

Harpham, Edward J.

1998-01-01

45

JAMES E. SMITH December 2013  

E-print Network

1 JAMES E. SMITH December 2013 ADDRESS Fuqua School of Business. #12;2 PUBLICATIONS David B. Brown and James E. Smith. 2012. "Optimal Sequential Exploration: Bandits, Clairvoyants, and Wildcats." Operations Research 61 (3), 644665. James E. Smith and Canan

Reif, John H.

46

Dean of Libraries Steven Smith  

E-print Network

Dean of Libraries Steven Smith Development Director Erin Horeni-Ogle Associate Dean for Collections Dean Rita Smith Assessment Business Services Community Learning Services & Diversity Programs Hodges Library Council (Advisory) #12;Dean Steven Smith Head, Special Collections Jennifer Beals Special

Wang, Xiaorui "Ray"

47

Smith Tackles Oakland Unified  

ERIC Educational Resources Information Center

As a 20-something, Anthony "Tony" Smith had fulfilled one dream: playing professional football for the Green Bay Packers and the San Francisco 49ers. Next up, he thought, was law school, but a former mentor reminded him that he is a teacher. Smith never became a classroom teacher, but his background in sports--where he learned the power of…

Mellon, Ericka

2011-01-01

48

An additional physical interpretation in the Luneburg-Kline expansion. [for reflected fields  

NASA Technical Reports Server (NTRS)

The Luneburg-Kline (LK) expansion provides an asymptotic representation of the reflected field from a smooth surface in inverse powers of k. The physical interpretation of the first term in the expansion has long been recognized. The physical significance of the second term is suggested here. Through analysis of the expansion for a parabolic, circular, and elliptic cylinders, further geometric information is seen other than the radius of curvature at the specular point. The other geometric information is the distance between the specular point and the incident shadow boundary.

Dominek, Allen K.; Peters, Leon, Jr.; Burnside, Walter D.

1987-01-01

49

Aaron Lee Smith The Dissertation Committee for Aaron Lee Smith  

E-print Network

Copyright by Aaron Lee Smith 2009 #12;The Dissertation Committee for Aaron Lee Smith certifies Compilation by Aaron Lee Smith, B.A., M.S. Dissertation Presented to the Faculty of the Graduate School thank my family for their encouragement. Aaron Lee Smith The University of Texas at Austin December 2009

John, Lizy Kurian

50

C. E. Smith, Page 1 of 2 Cartney E. Smith  

E-print Network

C. E. Smith, Page 1 of 2 Cartney E. Smith cesmith5@illinois.edu Education University of Illinois, C. E. Smith, K. Kim, H. Kong, "Tailoring Polymersome Bilayer Permeability Improves Enhanced. Vega L., M. K. Lee, J. H. Jeong, C. E. Smith, K. Y. Lee, H. J. Chung, D. E. Leckband, H. Kong

Bashir, Rashid

51

This article was downloaded by:[Smith, Bradley] [Smith, Bradley  

E-print Network

This article was downloaded by:[Smith, Bradley] [Smith, Bradley] On: 9 April 2007 Access Details. © Taylor and Francis 2007 #12;DownloadedBy:[Smith,Bradley]At:21:299April2007 Recent Advances in Synthetic Membrane Transporters BETH A. MCNALLY, W. MATTHEW LEEVY and BRADLEY D. SMITH* Department of Chemistry

Smith, Bradley D.

52

Smith et al Supporting Information  

E-print Network

Smith et al 1 Supporting Information for Smith et al. 2006, PLoS Computational Biology 2:e161-hyperpallium apicale; HF-hippocampal formation, and M-mesopallium. #12;Smith et al 2 FigureS2,nolinkswerefoundbetweenelectrodesindifferentbirds,andnolinkswerefoundintothesoundstimulusvariable. CombinedAnalysisofAllBirds'ElectrodesPlusSound #12;Smith et al 3 Analysis of Data from Subsections

Jarvis, Erich D.

53

The Relevance of Adam Smith  

NSDL National Science Digital Library

The Federal Reserve Bank of Richmond explores the relevance of eighteenth-century economist Adam Smith in today's world. Quoting heavily from Smith's famous work The Wealth of Nations, this article summarizes many of Smith's main themes and ideas, and attempts to prove that Smith's "ideas have become so thoroughly absorbed into our intellectual heritage that they are no longer identifiable as having originated with Adam Smith."

54

Adam Smith and dependency.  

PubMed

The focus of this paper is the works and life of Adam Smith, who is widely recognized as the father and founder of contemporary economics. Latent content analysis is applied to his seminal text in economics, An Inquiry into the Nature and Causes of the Wealth of Nations (1776). The results reveal that Smith considers dependence on others a problem and sees the solution to this problem in impersonalized interdependence. In addition, his views on social dependency and personal dependency, reflected in his Lectures on Jurisprudence (1963) and The Theory of Moral Sentiments (1759), are analyzed. This analysis suggests a central tension between dependence and independence in Smith's writings. The personal dependency patterns he exhibited in his life, which also suggest a tension between dependence and independence, are identified through a reading of his biographies. Based on insights from psychoanalytic literature, this paper proposes that developing the ideas in the Wealth of Nations was part of Smith's creative solution to this tension. In particular, his solution to one individual's dependence on another was through a system of impersonalized interdependence. In other words, Smith defended against his personal dependence through his economic theorizing. PMID:22712591

Ozler, Sule

2012-06-01

55

Catalytically Driven Colloidal Patterning and Transport Timothy R. Kline,, Jodi Iwata, Paul E. Lammert,, Thomas E. Mallouk,*,,,  

E-print Network

Catalytically Driven Colloidal Patterning and Transport Timothy R. Kline,, Jodi Iwata, Paul E. Introduction The electrophoretic movement of individual colloidal particles due to an applied electric field direct current (DC) electrophoretic deposition of particles into ordered arrays.8,9 Reports also exist

56

Solar Cycle Variability and Surface Differential Rotation from Ca II K-Line Time Series Data  

E-print Network

Analysis of over 36 years of time series data from the NSO/AFRL/Sac Peak K-line monitoring program elucidates five components of the variation of the seven measured chromospheric parameters: (a) the solar cycle (period ~ 11 years), (b) quasi-periodic variations (periods ~100 days), (c) a broad band stochastic process (wide range of periods), (d) rotational modulation, and (e) random observational errors, independent of (a)-(d). Correlation and power spectrum analyses elucidate periodic and aperiodic variation of these parameters. Time-frequency analysis illuminates periodic and quasi periodic signals, details of frequency modulation due to differential rotation, and in particular elucidates the rather complex harmonic structure (a) and (b) at time scales in the range ~0.1 - 10 years. These results using only full-disk data suggest that similar analyses will be useful at detecting and characterizing differential rotation in stars from stellar light-curves such as thosebeing produced by NASA's Kepler observator...

Scargle, Jeffrey; Worden, Pete

2013-01-01

57

Director HR Andrew J Smith  

E-print Network

Director HR Andrew J Smith Associate Director HR Shared Services Miya Chiba Associate Director Payroll Officer John Smith Systems & Project Analyst Blair Jordan HR Reporting Analyst Yana Zhang Manager

Liley, David

58

Ashley Wilder Smith's biography  

Cancer.gov

Ashley Wilder Smith, PhD, MPH is a Behavioral Scientist and Program Director in the Outcomes Research Branch of the Applied Research Program. Her program of research focuses on developing, advancing and promoting investigations related to improving current understanding of patient reported outcomes and quality care for cancer patients, survivors and families. In particular, Dr.

59

Copyright 2005 Veronica Susanne Smith  

E-print Network

Copyright 2005 Veronica Susanne Smith #12;Evaluating Spatial Normalization Methods for the Human Brain Veronica Susanne Smith A thesis submitted in partial fulfillment of the requirements for the Human Brain Veronica Susanne Smith Chair of the Supervisory Committee: Professor Linda S. Shapiro

Washington at Seattle, University of

60

Kevin Smith Sutherland House 234  

E-print Network

Kevin Smith Sutherland House 234 PMB 3342 Nashville, TN 37235 January 27, 2010 Mr. Scott at Kevin.m.smith@vanderbilt.edu or by phone at (543)3843909. Thank you for your consideration. Sincerely, Kevin Smith The cover letter needs to be in business letter format...this includes

Bordenstein, Seth

61

Victoria Anne Smith Curriculum Vitae  

E-print Network

Victoria Anne Smith Curriculum Vitae School of Biology anne.smith@st-andrews.ac.uk University of St-I £83,318 (of £4.5M) Oct 2006 ­ Sep 2010 #12;V. Anne Smith, Curriculum Vitae, Page 2 Past Research

Smith, V Anne

62

Presented by Jeremy C. Smith  

E-print Network

Presented by Biosystems Jeremy C. Smith Center for Molecular Biophysics Biosciences Division #12;2 Managed by UT-Battelle for the U.S. Department of Energy Smith_Biosystems_SC10 Simulation model and cellulose Length-scale1 nm 1 m * L. Petridis and J. C. Smith (2009), "A molecular mechanics force field

63

Deborah K. Smith Senior Scientist  

E-print Network

Deborah K. Smith Senior Scientist Woods Hole Oceanographic Institution Publications: Jordan, T. H., H. W. Menard, and D.K. Smith, Density and size distribution of seamounts in the eastern Pacific inferred from wide-beam sounding data, J. Geophys. Res., 88, 10508-10518, 1983. Kim, I. I., D. K. Smith, H

Smith, Deborah K.

64

World Vaccine Congress Lyon - Terrapinn's 11th Annual Congress.  

PubMed

The 11th Annual World Vaccine Congress, held in Lyon, included topics covering new therapeutic developments in the field of vaccines. This conference report highlights selected presentations on the role of big pharma in vaccine development, the future direction of vaccine R&D, influenza preparedness in Europe, and vaccines for Staphylococcus aureus, CMV and cancer. Investigational drugs discussed include an H5N1 influenza vaccine program from Baxter International Inc/DynPort Vaccine Co LLC, FP-01 (Immune Targeting Systems Ltd), FluGEM (Mucosis BV), a nonstructural protein-1-altered live-attenuated influenza vaccine candidate from Vivaldi Biosciences Inc, PentaStaph (GlaxoSmithKline plc) and StaphVAX (Nabi Biopharmaceuticals), VCL-CB01 (Vical Inc) and astuprotimut-r (GlaxoSmithKline). PMID:19943212

Sovran, Liza

2009-12-01

65

Smith–Magenis syndrome  

Microsoft Academic Search

Smith–Magenis syndrome (SMS) is a complex neurobehavioral disorder caused by haploinsufficiency of the retinoic acid-induced 1 (RAI1) gene on chromosome 17p11.2. Diagnostic strategies include molecular identification of a 17p11.2 microdeletion encompassing RAI1 or a mutation in RAI1. G-banding and fluorescent in situ hybridization (FISH) are the classical methods used to detect the SMS deletions, while multiplex ligation-dependent probe amplification (MLPA)

Sarah H Elsea; Santhosh Girirajan

2008-01-01

66

Sophia Smith Collection  

NSDL National Science Digital Library

As part of the Five College Archives Digital Access Project (mentioned in the September 25, 1998 Scout Report), Smith College has digitized some of its archival holdings relating to women's history. The Website of the Sophia Smith Collection presents still more of the Smith College holdingsof "manuscripts, photographs, periodicals and other primary sources in women's history." The site includes brief descriptions of over 300 manuscript collections, lesson plans for using primary source materials, links to additional women's history resources, and selected digital images. A permanent exhibition, Agents of Social Change, showcases some materials online. The exhibit contains pictures and digitized documents on eight 20th-century women and organizations working for women's rights. Visitors will find items such as a brochure about the National Congress of Neighborhood Women (NCNW), a grassroots feminist organization; a 1980 photo of an NCNW march on New York City Hall; Gloria Steinem photographed at the Ms. office in 1983; and fan mail to Steinem after a TV appearance.

1997-01-01

67

NIC23  

PubMed Central

The 23rd National Immunization Conference for Health Care Workers was held on December 7th, 2012 at the Manchester Conference Centre. There were over 220 delegates for this event sponsored by educational grants from Crucell, Glaxo Smith Kline, Pfizer Vaccines and Sanofi Pasteur. A number of speakers took the opportunity kindly afforded by Human Vaccines and Immunotherapeutics to write up their conference presentation as a paper for this special supplement. PMID:23857271

Baxter, David; Guppy, Martin J.

2013-01-01

68

An Invitation to Open Innovation in Malaria Drug Discovery: 47 Quality Starting Points from the TCAMS  

PubMed Central

In 2010, GlaxoSmithKline published the structures of 13533 chemical starting points for antimalarial lead identification. By using an agglomerative structural clustering technique followed by computational filters such as antimalarial activity, physicochemical properties, and dissimilarity to known antimalarial structures, we have identified 47 starting points for lead optimization. Their structures are provided. We invite potential collaborators to work with us to discover new clinical candidates. PMID:24900261

2011-01-01

69

Novel PPAR? Agonists GI 262570, GW 7845, GW 1929, and Pioglitazone Decrease Calcium Channel Function and Myogenic Tone in Rat Mesenteric Arteries  

Microsoft Academic Search

Novel non-thiazolidinedione, tyrosine-derived peroxisome proliferator-activated receptor ? agonists, GI 262570, GW 7845, GW 1929, developed by GlaxoSmithKline (GSK) along with pioglitazone and nisoldipine, were studied on currents through L-type voltage-dependent calcium channels (VDCC) in freshly isolated smooth muscle cells from mesenteric arteries, and on the diameter of pressurized mesenteric arteries in vitro. Using Ba2+ (10 mmol\\/l) as the charge carrier

Thomas J. Heppner; Adrian D. Bonev; Delrae M. Eckman; Maria F. Gomez; Georgi V. Petkov; Mark T. Nelson

2005-01-01

70

Insect Cell-Based Recombinant Protein Production  

Microsoft Academic Search

\\u000a Insect cells in conjunction with the baculovirus expression vector (BEV) system represent a fast and efficient system for\\u000a the generation of recombinant tool proteins (mg- to g-range). This is quite evident from scores of application reports which\\u000a have been published since 1970. Moreover, the European approval of the vaccine Cervarix (for cervical cancer) from Glaxo SmithKline\\u000a in autumn 2007 and

W. Weber; M. Fussenegger

71

Drug advertisements: A prescription for misleading and deceptive conduct?  

Microsoft Academic Search

The Federal Court recently considered the application of a s 52 of the Trade Practices Act 1974 (Cth) (the Act) to the sophisticated marketing practices of pharmaceutical companies extolling the virtues of complex products to a specialised audience. In AstraZeneca Pty Ltd v GlaxoSmithKline Australia Pty Ltd [2005] FCA 1645, the court was required to consider whether suggesting to doctors

Damien Millen

2006-01-01

72

Ezogabine (retigabine).  

PubMed

Ezogabine (Potiga; Valeant Pharmaceuticals/GlaxoSmithKline), a potassium channel opener, was approved in June 2011 by the U.S. Food and Drug Administration (F.D.A.) for the adjunctive treatment of partial-onset seizures in adult patients. The same drug was granted marketing authorization for this indication in the European Union in March 2011, where it is known as retigabine (Trobalt). PMID:21959281

Stafstrom, Carl E; Grippon, Seden; Kirkpatrick, Peter

2011-10-01

73

Safety, reactogenicity, and immunogenicity of live attenuated varicella vaccine in children between 1 and 9 years of age with atopic dermatitis  

Microsoft Academic Search

Infection with varicella-zoster virus (VZV) is known to facilitate secondary bacterial infection, which is cause for particular concern in children with atopic dermatitis. This 2-year study assessed the safety, reactogenicity, and immunogenicity of a live attenuated Oka strain varicella vaccine (Varilrix, GlaxoSmithKline Biologicals) in 160 children aged 1–9 years with atopic dermatitis randomized to vaccination at the start of either the

Hans Wolfgang Kreth; Peter Hans Hoeger

2006-01-01

74

Applying Counting Techniques Shelly Smith  

E-print Network

Applying Counting Techniques To Sudoku Shelly Smith 7 4 5 4 8 3 4 1 9 4 8 2 7 3 4 1 1 5 1 5 1 1 1 1 3 8 8 79 5 3 June 15, 2009 Shelly Smith Applying Counting TechniquesTo Sudoku #12;How many ways...? How many ways can we put the integers 1 through 5 in the spaces below if order matters? Shelly Smith

Tefera, Akalu

75

Getting to know Joseph Smith  

NSDL National Science Digital Library

In these simple modules you will commit to memory 6 important dates in the life of Joseph Smith. Attempt to remember the date before clicking on the link directly under the picture. Write the dates in your journal and present the journal to Bro. Davidson for credit Joseph Smith was born in Sharon, Windsor county, Vermont in _____? Cute baby boy Birth date The first vision occurred in _____? first vision First vision date Moroni then visits the prophet in ____? Moroni Moroni visitations Joseph marries Emma ____? Emma Smith Marriage The church is officially reorganized in ____? Church restored Restoration Joseph and Hyrum martyred in ____? Martyrdom of Joseph Smith Martyrdom ...

Davidson, Bro.

2010-06-09

76

SOLAR CYCLE VARIABILITY AND SURFACE DIFFERENTIAL ROTATION FROM Ca II K-LINE TIME SERIES DATA  

SciTech Connect

Analysis of over 36 yr of time series data from the NSO/AFRL/Sac Peak K-line monitoring program elucidates 5 components of the variation of the 7 measured chromospheric parameters: (a) the solar cycle (period {approx} 11 yr), (b) quasi-periodic variations (periods {approx} 100 days), (c) a broadband stochastic process (wide range of periods), (d) rotational modulation, and (e) random observational errors, independent of (a)-(d). Correlation and power spectrum analyses elucidate periodic and aperiodic variation of these parameters. Time-frequency analysis illuminates periodic and quasi-periodic signals, details of frequency modulation due to differential rotation, and in particular elucidates the rather complex harmonic structure (a) and (b) at timescales in the range {approx}0.1-10 yr. These results using only full-disk data suggest that similar analyses will be useful for detecting and characterizing differential rotation in stars from stellar light curves such as those being produced by NASA's Kepler observatory. Component (c) consists of variations over a range of timescales, in the manner of a 1/f random process with a power-law slope index that varies in a systematic way. A time-dependent Wilson-Bappu effect appears to be present in the solar cycle variations (a), but not in the more rapid variations of the stochastic process (c). Component (d) characterizes differential rotation of the active regions. Component (e) is of course not characteristic of solar variability, but the fact that the observational errors are quite small greatly facilitates the analysis of the other components. The data analyzed in this paper can be found at the National Solar Observatory Web site http://nsosp.nso.edu/cak{sub m}on/, or by file transfer protocol at ftp://ftp.nso.edu/idl/cak.parameters.

Scargle, Jeffrey D.; Worden, Simon P. [NASA Ames Research Center, Moffett Field, CA, 94035 (United States); Keil, Stephen L. [National Solar Observatory, P.O. Box 57, Sunspot, NM 88349 (United States)

2013-07-01

77

Genetics Home Reference: Smith-Magenis syndrome  

MedlinePLUS

... gov Research studies OMIM Genetic disorder catalog Conditions > Smith-Magenis syndrome On this page: Description Genetic changes ... names Glossary definitions Reviewed December 2013 What is Smith-Magenis syndrome? Smith-Magenis syndrome is a developmental ...

78

Robustness of multivariable smith predictors  

Microsoft Academic Search

Stability and stability robustness of multivariable Smith predictors are analysed by viewing Smith predictors as instances of Internal Model Con- trol. This allows a much simpler development than appears in previous analyses, and the way that delays enter the plant transfer function matrix is unrestricted. It is shown that robustness to additive plant perturbations can be predicted during design, on

J. M. Maciejowski

1994-01-01

79

Circuit reconstruction tools today Stephen J Smith  

E-print Network

Circuit reconstruction tools today Stephen J Smith To understand how a brain processes information, Stanford University School of Medicine, Stanford, CA 94305, United States Corresponding author: Smith

Born, Richard

80

Evaluating baseball bat performance L. V. Smith  

E-print Network

Evaluating baseball bat performance L. V. Smith School of Mechanical and Materials Engineering address: L. V. Smith, School of Mechanical and Materials Engineering, Washington State University, Pullman

Smith, Lloyd V.

81

Sophia Smith Collection: Women's History Archives at Smith College  

NSDL National Science Digital Library

The Sophia Smith Collection at Smith College was made possible under the guidance of its first director, Margaret Storrs Grierson. In 1946, it was named in honor of the founder of Smith College and it has grown to include over 650 different thematic collections. On this page, visitors can browse through their online image collections, oral histories, and exhibits. The oral histories are quite a treat, as they include 50 in-depth interviews which document the persistence and diversity of organizing for women in the United States. Additionally, this area contains interviews on population and reproductive health and conversations with student activists at Smith College. The Online Exhibits area includes nine thematic collections. One of the most interesting among them is the Girl Zines collection, which features independent magazines that address "third wave" feminism and sexuality. Finally, visitors can use the Finding Images section to look over 300 items that include political buttons, handicrafts, and cartoons.

2012-07-13

82

Adrienne Smith Long, Doctoral Fellow  

Cancer.gov

Adrienne Smith graduated summa cum laude from McCormick School of Engineering at Northwestern University in 2008 with a Bachelors of Science in Biomedical Engineering and matriculated into the Feinberg School of Medicine at Northwestern in 2008.

83

Maynard Smith, optimization, and evolution  

Microsoft Academic Search

Maynard Smith’s defenses of adaptationism and of the value of optimization theory in evolutionary biology are both criticized.\\u000a His defense does not adequately respond to the criticism of adaptationism by Gould and Lewontin. It is also argued here that\\u000a natural selection cannot be interpreted as an optimization process if the objective function to be optimized is either (i)\\u000a interpretable as

Sahotra Sarkar

2005-01-01

84

Cowboy Photographer: Erwin E. Smith  

NSDL National Science Digital Library

While many are familiar with the romantic notion of the American cowboy as crafted by Frederic Remington and Charles M. Russell, few share intimate knowledge of a lesser known artist, Erwin E. Smith. This online exhibit, created by the Amon Carter Museum in Texas, seeks to rectify that situation through this extensive archive of photographs by Smith that capture the world of the cowboy around the turn of the 20th century. Smith grew up in Texas collecting prints of paintings by artists like George Catlin and Frederic Remington. He later ended up studying art with Lorado Taft at the Art Institute of Chicago, and then at the School of the Boston Museum of Fine Arts. Smith later moved back West, and between 1905 and 1912, he took thousands of photographs on ranches throughout Texas, New Mexico, and Arizona. The photographs available online here are divided into several main sections for convenient browsing, including Cowhand clothing, Rodeo, and Ranches. Along with a biography of Smith, the site also includes a glossary of terms used by cowboys and ranchers, as well as several teaching resources for educators.

85

Turbulent Fluctuations in G-band and K-line Intensities Observed with the Rapid Oscillations in the Solar Atmosphere (ROSA) Instrument  

NASA Astrophysics Data System (ADS)

Using the Rapid Oscillation in the Solar Atmosphere (ROSA) instrument at the Dunn Solar Telescope we have found that the spectra of fluctuations of the G-band (cadence 1.05 s) and Ca II K-line (cadence 4.2 s) intensities show correlated fluctuations above white noise out to frequencies beyond 300 mHz and up to 70 mHz, respectively. The noise-corrected G-band spectrum presents a scaling range (Ultra High Frequency “UHF”) for f = 25-100 mHz, with an exponent consistent with the presence of turbulent motions. The UHF power, is concentrated at the locations of magnetic bright points in the intergranular lanes, it is highly intermittent in time and characterized by a positive kurtosis ?. Combining values of G-band and K-line intensities, the UHF power, and ?, reveals two distinct “states” of the internetwork solar atmosphere. State 1, with ? ? 6, which includes almost all the data, is characterized by low intensities and low UHF power. State 2, with ? ? 3, including a very small fraction of the data, is characterized by high intensities and high UHF power. Superposed epoch analysis shows that for State 1, the K-line intensity presents 3.5 min chromospheric oscillations with maxima occurring 21 s after G-band intensity maxima implying a 150-210 km effective height difference. For State 2, the G-band and K-line intensity maxima are simultaneous, suggesting that in the highly magnetized environment sites of G-band and K-line emission may be spatially close together. Analysis of observations obtained with Hinode/SOT confirm a scaling range in the G-band spectrum up to 53 mHz also consistent with turbulent motions as well as the identification of two distinct states in terms of the H-line intensity and G-band power as functions of G-band intensity.

Cadavid, A. C.; Lawrence, J. K.; Christian, D. J.; Jess, D. B.; Mathioudakis, M.

2012-12-01

86

Smith Purcell radiation from femtosecond electron bunches  

E-print Network

We present theoretical and experimental results from a Smith-Purcell radiation experiment using the electron beam from a 17 GHz high gradient accelerator. Smith- Purcell radiation occurs when a charged particle travels ...

Korbly, Stephen E

2005-01-01

87

Introducing Reference Semantics via Refinement Graeme Smith  

E-print Network

Introducing Reference Semantics via Refinement Graeme Smith Software Verification Research Centre, University of Queensland, Australia smith@svrc.uq.edu.au Abstract. Two types of semantics have been given

Smith, Graeme

88

Stepwise Development from Ideal Specifications Graeme Smith  

E-print Network

Stepwise Development from Ideal Specifications Graeme Smith Software Verification Research Centre University of Queensland, Australia smith@svrc.uq.edu.au Abstract The stepwise development of a program using

Smith, Graeme

89

Towards robot audition Leslie S. Smith  

E-print Network

Towards robot audition Leslie S. Smith Department of Computing Science and Mathematics, University in illumination, and auditory systems can detect changes in room reverberation. #12;2 Leslie S. Smith Another key

Smith, Leslie S.

90

Am I spikes over time? Leslie Smith  

E-print Network

Am I spikes over time? Leslie Smith Computing Science and Mathematics University of Stirling Stirling FK9 4LA, UK Email: l.s.smith@cs.stir.ac.uk URL: http://www.cs.stir.ac.uk/~lss Acknowledgements: EU

Smith, Leslie S.

91

The RB Language Jonathan M. Smith  

E-print Network

­­ ­­ The RB Language Jonathan M. Smith Distributed Systems Laboratory Department of Computer of an attempt to generate more practical examples of the scheme described by Smith and Maguire for ``competitive

92

Adversaries and Information Leaks Geoffrey Smith  

E-print Network

Adversaries and Information Leaks (Tutorial) Geoffrey Smith School of Computing and Information-Verlag Berlin Heidelberg 2008 #12;384 G. Smith ­ The program c has direct access to the sensitive information

Smith, Geoffrey

93

Fundamental Ideas of Mathematics Instructor: Sam Smith  

E-print Network

Math 225 Fundamental Ideas of Mathematics Syllabus Fall 2013 Instructor: Sam Smith Office: Barbelin 228, 610-660-1559, smith@sju.edu Office Hours: Tue, Thur 12:00-2:00 or by appointment. Text: Chartrand

Smith, Sam

94

Maynard Smith, optimization, and evolution  

Microsoft Academic Search

Maynard Smith's defenses of adaptationism and of the value of optimization theory in evolutionary biology are both criticized. His defense does not adequately respond to the criticism of adaptationism by Gould and Lewontin. It is also argued here that natural selection cannot be interpreted as an optimization process if the objective function to be optimized is either (i) inter- pretable

SAHOTRA SARKAR

2005-01-01

95

Smith Mammal Body Mass Data  

NSDL National Science Digital Library

Data compiled on body mass information for 5731 mammalian species. Felisa A. Smith, S. Kathleen Lyons, S. K. Morgan Ernest, Kate E. Jones, Dawn M. Kaufman, Tamar Dayan, Pablo A. Marquet, James H. Brown, and John P. Haskell. 2003. Body mass of late Quaternary mammals. Ecology 84:3403

Ethel Stanley (Beloit College;Biology)

2009-01-10

96

Arthur Smith, Local Baptist Pastor.  

ERIC Educational Resources Information Center

Written and published by the students at Gary High School this volume has three articles dealing with East Texas life. The first "Arthur Smith" (David Hancock and others) is an account of growing up in Marian County, Texas is described by the local Baptist minister. The pastor begins with the year of his birth and gives detailed information about…

Heaton, Moss, Ed.

1985-01-01

97

August 2012 Linda B. Smith  

E-print Network

August 2012 Linda B. Smith Department of Psychological and Brain Sciences & The Program University, 1982 James McKeen Cattell Sabbatical Award, 1984 (declined) Research Career Development Award Institutes of Health, Scientific Review Advisory Committee, 1997 Society for Research In Child Development

Indiana University

98

January 2010 Linda B. Smith  

E-print Network

January 2010 Linda B. Smith Department of Psychological and Brain Sciences & The Program University, 1982 James McKeen Cattell Sabbatical Award, 1984 (declined) Research Career Development Award for Research In Child Development, Ethics Committee, 1997-1999 National Institutes of Health, Study Section

Indiana University

99

The Coverage of Operational Scott F. Smith  

E-print Network

The Coverage of Operational Semantics Scott F. Smith Department of Computer Science The Johns (Talcott 1989), types and objects (Gordon and Rees 1996), and distributed objects (Agha, Mason, Smith text can 1 #12;2 Smith distinguish the two. This program text can be viewed as a particular "test

Smith, Scott F.

100

Arras User's Manual John B. Smith  

E-print Network

Arras User's Manual TR85-036 1985 John B. Smith The University of North Carolina at Chapel Hill'S MANUAL John B. Smith Department or Computer Science University or North Carolina Chapel Hill, North Carolina 27514 Copyright© 1984 by John B. Smith #12;Starling ARRAS Note for those not using TUCC: The ARRAS

North Carolina at Chapel Hill, University of

101

Derek J. Smith Department of Computer Science  

E-print Network

Derek J. Smith Candidate Department of Computer Science Department This dissertation is approved, Modeling, and Application to Vaccine Design by Derek J. Smith B.Sc., Computer Science, University Mexico Albuquerque, New Mexico December 1997 #12;#12;c 1997, Derek J. Smith v #12;#12;For Dorothy, Mabel

Forrest, Stephanie

102

Math in Microbiology Hal L. Smith  

E-print Network

Math in Microbiology Hal L. Smith PSA 631 halsmith@asu.edu School of Mathematics and Statistics Arizona State University H.L.Smith (A.S.U.) Math in Microbiology Microbiology, January 2009 1 / 22 #12 for Nutrient 4 Bacteriophage and Bacteria in Chemostat 5 Food Chain H.L.Smith (A.S.U.) Math in Microbiology

Smith, Hal

103

A new modified Smith predictor design  

Microsoft Academic Search

By combining several existing modified Smith predictor structures, presented in a literature review, a generalised form of the Smith predictor is proposed. From this structure, excellent servo and regulator responses can be obtained by specifying three controller dynamic elements. Two new modified Smith predictor structures are presented with their associated tuning rules. The results of the simulations indicate that the

Pauline Sourdille; Aidan O'Dwyer

2003-01-01

104

BOUNDS FOR SPECTRAL CLUSTERS HART F. SMITH  

E-print Network

Lq BOUNDS FOR SPECTRAL CLUSTERS HART F. SMITH Abstract. In these notes, we review recent results] establish the same estimates under the assumption that the metric is C1,1. It is known by examples of Smith to the wave equation. The author was supported in part by NSF grant DMS-0140499. 1 #12;2 HART F. SMITH

Smith, Hart F.

105

Econophysical visualization of Adam Smith’s invisible hand  

NASA Astrophysics Data System (ADS)

Consider a complex system whose macrostate is statistically observable, but yet whose operating mechanism is an unknown black-box. In this paper we address the problem of inferring, from the system’s macrostate statistics, the system’s intrinsic force yielding the observed statistics. The inference is established via two diametrically opposite approaches which result in the very same intrinsic force: a top-down approach based on the notion of entropy, and a bottom-up approach based on the notion of Langevin dynamics. The general results established are applied to the problem of visualizing the intrinsic socioeconomic force-Adam Smith’s invisible hand-shaping the distribution of wealth in human societies. Our analysis yields quantitative econophysical representations of figurative socioeconomic forces, quantitative definitions of “poor” and “rich”, and a quantitative characterization of the “poor-get-poorer” and the “rich-get-richer” phenomena.

Cohen, Morrel H.; Eliazar, Iddo I.

2013-02-01

106

Fukushima to receive Smith Medal  

NASA Astrophysics Data System (ADS)

The 1990 Waldo E. Smith Medal for extraordinary service to geophysics will be given to Naoshi Fukushima, who earned an international reputation for his pioneering work in geomagnetic disturbance and ionospheric electric currents. Now retired from the University of Tokyo, Japan, Fukushima is being cited for his public service to international geophysics, and, in particular, his contributions to the International Association of Geomagnetism and Aeronomy, of which he was Secretary General from September 1975 to August 1983.The Smith Medal will be presented as part of the AGU Fall Meeting Honors Night festivities, Wednesday, December 5, in San Francisco, Calif. Three James B. Macelwane Medals, the John Adam Fleming Medal, and the Maurice Ewing Medal will also be presented (see Eos, February 20, 1990, p. 294).

107

Street & Smith's Preservation Access Project  

NSDL National Science Digital Library

For thousands of Americans throughout the 19th and early 20th centuries, dime novels and pulp magazines were their first experiences with the emerging world of mass-produced material culture. One such purveyor was the Street & Smith publishing house, which began in 1855 and published a wide variety of popular literature (such as homemaking magazines, comics, and dime novels) for over 100 years. These products didn't often have a great deal of originality, as the company viewed fiction as a commodity, and editors dictated plots and characters to writers, a list that included Horatio Alger, Upton Sinclair, and Jack London. This Web site, an online exhibit presented by the Syracuse University Library, pays homage to this publishing house with a number of scanned digitized images of the Street & Smith dime novels, a cover art gallery, and a collection of images immortalizing that most famous comic strip character, the Yellow Kid.

108

William Smith (1769-1839)  

NSDL National Science Digital Library

This brief history of William Smith, who initiated the Principle of Faunal Succession, covers his early education, his employment as an assistant surveyor to Edward White, and his time as construction supervisor of the Somerset Canal in southwestern England. The text explains his production of a geological map of England and final recognition in 1831, when he received the Wollaston Medal, the highest honor awarded each year for outstanding achievement in geology by the Geological Society of London.

109

Near-coincident K-line and K-edge energies as ionization diagnostics for some high atomic number plasmas  

SciTech Connect

For some high atomic number atoms, the energy of the K-edge is tens of eVs higher than the K-line energy of another atom, so that a few eV increase in the line's energy results in a decreasing transmission of the x-ray through a filter of the matching material. The transmission of cold iridium's Asymptotically-Equal-To 63.287 keV K{alpha}{sub 2} line through a lutetium filter is 7% lower when emitted by ionized iridium, consistent with an energy increase of {Delta}{epsilon} Asymptotically-Equal-To 10{+-}1 eV associated with the ionization. Likewise, the transmission of the K{beta}{sub 1} line of ytterbium through a near-coincident K-edge filter changes depending on plasma parameters that should affect the ionization. Systematic exploration of filter-line pairs like these could become a unique tool for diagnostics of suitable high energy density plasmas.

Pereira, N. R. [Ecopulse, Inc., P.O. Box 528, Springfield, Virginia 22150 (United States); Weber, B. V.; Phipps, D. G.; Schumer, J. W. [Naval Research Laboratory, Washington, DC 20375 (United States); Seely, J. F. [Artep, Inc., 2922 Excelsior Springs Court, Ellicott City, Maryland 21042 (United States); Carroll, J. J. [Army Research Laboratory, Adelphi, Maryland 20873 (United States); Vanhoy, J. R. [United States Naval Academy, Annapolis, Maryland 21402 (United States); Slabkowska, K.; Polasik, M. [Faculty of Chemistry, Nicolaus Copernicus University, Gagarina 7, 87-100 Torun (Poland)

2012-10-15

110

Iterative learning control design for Smith predictor  

Microsoft Academic Search

The Smith predictor has been used to improve the closed-loop performance for systems with time delays. This paper proposes a frequency-domain method to design an iterative learning control to further improve the performance of Smith predictor controller. For a time-invariant plant with multiplicative perturbations and a Smith predictor controller, we derive a sufficient and necessary condition (which has the same

Qiuping Hu; Jian-Xin Xu; Tong Heng Lee

2001-01-01

111

Genetics Home Reference: Smith-Lemli-Opitz syndrome  

MedlinePLUS

... gov Research studies OMIM Genetic disorder catalog Conditions > Smith-Lemli-Opitz syndrome On this page: Description Genetic ... names Glossary definitions Reviewed July 2007 What is Smith-Lemli-Opitz syndrome? Smith-Lemli-Opitz syndrome is ...

112

ON MONOIDS WITH A SINGLE DEFINING RELATOR G. C. Smith  

E-print Network

. Smith Abstract. This paper concerns single-relator monoid presentations, and di* *scusses Eileen and Roy Smith on the occasion of their Golden Wedding Anniversary;2 G. C. SMITH Results The first result shows that Johnson

Smith, Geoff

113

The Treatment of Smith's Invisible Hand  

ERIC Educational Resources Information Center

Adam Smith used the metaphor of an invisible hand to represent the instincts of human nature that direct behavior. Moderated by self-control and guided by proper institutional incentives, actions grounded in instincts can be shown to generate a beneficial social order even if not intended. Smith's concept, however, has been diluted and distorted…

Wight, Jonathan B.

2007-01-01

114

Bringing Sally Smith's Vision to Manayunk  

ERIC Educational Resources Information Center

In this article, the author narrates her application of what she learned from her internship at Sally Smith's Lab School of Washington to her new school and shares the favorable impact it had brought on her teaching career. The author shares her first exposure to the powerful effects of Smith's "Live It, Learn It" methodology as she encountered a…

Ford, Jackie

2010-01-01

115

Smith Predictor Design for Robust Performance  

Microsoft Academic Search

A method is outlined for designing Smith predictor controllers that provide robust performance despite real parameter uncertainties in the process model. Insight into the design process is gained by viewing the Smith predictor from the perspective of Internal Model Control. Performance requirements are written in terms of a frequency-domain weight restricting the magnitude of the closed-loop sensitivity function. A general

Daniel L. Laughlin; Manfred Morari

1987-01-01

116

Becoming and unbecoming: Stevie Smith as performer  

Microsoft Academic Search

This article examines British poet Stevie Smith's adoption of a childlike persona in her 1960's performances in the context of Victorian and modernist discourses of childhood. I argue that Smith made use of these discourses’ notion of childhood as a period of freedom in order to critique traditional notions of femininity, beginning in her poetry of the 1930's, continuing in

Laura Severin

1998-01-01

117

Environmental assessment: Deaf Smith County site, Texas  

SciTech Connect

In February 1983, the US Department of Energy (DOE) identified a location in Deaf Smith County, Texas, as one of nine potentially acceptable sites for a mined geologic repository for spent nuclear fuel and high-level radioactive waste. To determine their suitability, the Deaf Smith County site and the eight other potentially sites have been evaluated in accordance with the DOE's General Guidelines for the Recommendation of Sites for the Nuclear Waste Repositories. The Deaf Smith County site is in the Permian Basin, which is one of five distinct geohydrologic settings considered for the first repository. On the basis of the evaluations reported in this EA, the DOE has found that the Deaf Smith County site is not disqualified under the guidelines. On the basis of these findings, the DOE is nominating the Deaf Smith County site as one of the five sites suitable for characterization. 591 refs., 147 figs., 173 tabs.

Not Available

1986-05-01

118

A Survey of Process Migration Mechanisms Jonathan M. Smith  

E-print Network

A Survey of Process Migration Mechanisms Jonathan M. Smith Computer Science Department Columbia Migration Mechanisms Jonathan M. Smith Computer Science Department Columbia University New York, NY 10027

Smith, Jonathan M.

119

The genetics of a pharma merger.  

PubMed

The 1990s and early years of this century have seen a series of large-scale mergers and acquisitions in the Pharmaceutical and Biotech arena. These activities each required integration at multiple levels. One of the most important activities is the integration of the R&D pipelines of the participants. We outline the combined portfolio and bioinformatic strategy that was used, and detail the lessons learned for the longer term, from the GlaxoWellcome-SmithKline-Beecham merger in 2000. To date, this has been the largest merger of two equally sized Pharma R&D organisations. PMID:19121408

Sanseau, Philippe; Chabot-Fletcher, Marie; Browne, Michael J

2009-04-01

120

Environmental assessment, Deaf Smith County site, Texas  

SciTech Connect

The Nuclear Waste Policy Act of 1982 (42 USC sections 10101-10226) requires the environmental assessment of a proposed site to include a statement of the basis for nominating a site as suitable for characterization. Volume 2 provides a detailed statement evaluating the site suitability of the Deaf Smith County Site under DOE siting guidelines, as well as a comparison of the Deaf Smith County Site to the other sites under consideration. The evaluation of the Deaf Smith County Site is based on the impacts associated with the reference repository design, but the evaluation will not change if based on the Mission Plan repository concept. The second part of this document compares the Deaf Smith County Site to Davis Canyon, Hanford, Richton Dome and Yucca Mountain. This comparison is required under DOE guidelines and is not intended to directly support subsequent recommendation of three sites for characterization as candidate sites. 259 refs., 29 figs., 66 refs. (MHB)

Not Available

1986-05-01

121

Public Attitudes toward Homosexuality Tom W. Smith  

E-print Network

1 Public Attitudes toward Homosexuality Tom W. Smith NORC/University of Chicago September, 2011 Public opinion on homosexual behavior is sharply divided to the opposite judgment that homosexual behavior was "not wrong at all." Just 11% were

Stephens, Matthew

122

RANDALL KNOWLES SMITH High Energy Astrophysics Division  

E-print Network

RANDALL KNOWLES SMITH High Energy Astrophysics Division Smithsonian Astrophysical Observatory, MS 2) Current Position: 2008 ­ Astrophysicist, Smithsonian Astrophysical Observatory Professional Responsibilities: Secretary, High Energy Astrophysics Division of the American Astronomical Society Chair, COSPAR

123

Environmental assessment: Deaf Smith County site, Texas  

SciTech Connect

In February 1983, the US Department of Energy (DOE) identified a location in Deaf Smith County, Texas, as one of the nine potentially acceptable sites for mined geologic repository for spent nuclear fuel and high-level radioactive waste. To determine their suitability, the Deaf Smith County site and eight other potentially acceptable sites have been evaluated in accordance with the DOE's General Guidelines for the Recommendation of Sites for the Nuclear Waste Repositories. The Deaf Smith County site is in the Permian Basin, which is one of five distinct geohydrologic settings considered for the first repository. On the basis of the evaluations reported in this EA, the DOE has found that the Deaf Smith County site is not disqualified under the guidelines.

Not Available

1986-05-01

124

Reciprocity theorem for Smith-Purcell radiation  

Microsoft Academic Search

Smith-Purcell radiation is produced when a charged particle moves close and parallel to a diffraction grating. Calculation of Smith-Purcell spectra is therefore linked to a special grating problem, involving incident evanescent waves describing the field of the moving electron. For large period gratings, radiation in the far-infrared and millimetric range is produced, in a spectral range where metallic gratings can

O. Haeberlé

1997-01-01

125

J. E. Smith C. M. Smith C. L. Hunter An experimental analysis of the effects of herbivory and nutrient  

E-print Network

REPORT J. E. Smith á C. M. Smith á C. L. Hunter An experimental analysis of the effects become increasingly common (Smith et al. 1981; Hughes et al. 1987; Lapointe 1997; McClanahan et al. 1999 lead to substantial changes in ben- thic community structure (Smith et al. 1981; Littler and Littler

Smith, Jennifer E.

126

The Devil in Mr. Smith: A Conversation with Jonathan Z. Smith  

ERIC Educational Resources Information Center

This interview was recorded in November 2012 in Jonathan Z. Smith's Hyde Park graystone. Professor Smith offers insights into how he thinks about his classroom teaching and his students' learning through descriptions of various assignments and classroom activities he has developed over more than forty years of teaching. The discussion…

Smith, Jonathan Z.; Pearson, Thomas; Gallagher, Eugene V.; Jensen, Tim; Fujiwara, Satoko

2014-01-01

127

Principles of Secure Information Flow Analysis Geoffrey Smith  

E-print Network

Principles of Secure Information Flow Analysis Geoffrey Smith School of Computing and Information to explain the #12;2 Geoffrey Smith principles underlying secure information flow analysis and to discuss

Smith, Geoffrey

128

Rapid location of mount points JONATHAN M. SMITH  

E-print Network

­­ ­­ Rapid location of mount points JONATHAN M. SMITH Computer Science Department, Columbia ``core'' is ``/u2/smith/core''. The current directory is a directory­valued variable. It is an implied

129

Specifying mode requirements of embedded systems Graeme Smith  

E-print Network

Specifying mode requirements of embedded systems Graeme Smith Software Verification Research Centre University of Queensland, Australia Email: smith@svrc.uq.edu.au Abstract This paper presents a formal

Smith, Graeme

130

The Task of the Referee Alan Jay Smith  

E-print Network

The Task of the Referee * Alan Jay Smith Computer Science Division EECS Department University professional. Typically, referees learn to ¡ ¡ ¡ ¡ ¡ ¡ ¡ ¡ ¡ ¡ ¡ ¡ ¡ ¡ ¡ ¡ ¡ * Prof. Smith's research

Torr, Philip H. S.

131

Dual Models of Permutation Problems Barbara M. Smith  

E-print Network

Dual Models of Permutation Problems Barbara M. Smith School of Computing & Mathematics University of Huddersfield Huddersfield HD1 3DH, U.K. b.m.smith@hud.ac.uk Abstract. A constraint satisfaction problem

Smith, Barbara M.

132

H.O. SMITH BOTANIC GARDENS Welcome through Childhood's Gate,  

E-print Network

H.O. SMITH BOTANIC GARDENS Welcome through Childhood's Gate, the children's garden in the H.O Smith materials and tools are to remain in the garden for others to enjoy. Be aware of the needs of others

Boyer, Elizabeth W.

133

Music: Was Bessie Smith a feminist?  

Microsoft Academic Search

Angela Y. Davis, Blues Legacies and Black Feminism: Gertrude “Ma” Rainey, Bessie Smith, and Billie Holiday (Pantheon Books, 1998)I Can't Be Satisfied: Early American Women Blues Singers—Town & Country. Vol. 1, Country; Vol. 2, Town (Yazoo, 1997)

David Suisman

1999-01-01

134

Groups and their Representations Karen E. Smith  

E-print Network

Groups and their Representations Karen E. Smith #12;#12;1. Preface There are many people at the undergraduate or even beginning graduate level. Why not? It is concrete, full of beautifully elegant theorems. These notes represent the first half of that course; the second half dealt with Lie Groups. The audience

Smith, Karen E.

135

Wallace G. Smith Wallace W. Morse  

E-print Network

in a multinational field program that represented the starting point of the Northeast Fisheries Science Center that began in th.e mid 1960s. During theWallace G. Smith Wallace W. Morse Sandy Hook laboratory. Northeast Fisheries Science Center

136

OBITUARY: Hylton Smith (1927-2001)  

Microsoft Academic Search

Hylton Smith, recently the Scientific Secretary of the International Commission on Radiological Protection (ICRP), died at home on 10 June 2001, after several years of struggle against cancer. Hylton came to radiological protection via biochemistry, pharmacology, and radiobiology, perhaps an unusual route, but one that made him a valuable colleague in his final profession. He graduated at Newcastle in 1951

John Dunster

2001-01-01

137

Immunological Memory is Associative Derek J. Smith  

E-print Network

Immunological Memory is Associative Derek J. Smith Department of Computer Science University of New Laboratory Los Alamos, NM 87545, USA asp@t10.lanl.gov Abstract This paper argues that immunological memory population in the immune system). Keywords: Immunological Memory, Associative Memory, Cross-Reactive Memory

Somayaji, Anil

138

Jason Owen-Smith Associate Professor  

E-print Network

Cell Research Goes Global." Stem Cell Reviews and Reports Doi: 10.1007/s12015-012-9391-6. 2011 Scott Trajectories in Pluripotent Stem Cell Research." Cell. 145(6): 820-826. 2011 Owen-Smith, Jason. "The, University Re- search Commercialization, Regional Economic Development, Science Policy, Stem Cells, Collabo

Edwards, Paul N.

139

Margaret E. Smith Department of Plant  

E-print Network

Margaret E. Smith Professor Department of Plant Breeding & Genetics Cornell University G42 Emerson this agreement, please feel free to contact me. As in the past, our aim will be to help you evaluate your hybrids or other traits for which we are able to collect high quality data. Hybrids will be planted in tests

Pawlowski, Wojtek

140

Scientific Name: Hymenoptera: Megachilidae Megachile sculpturalis Smith  

E-print Network

Scientific Name: Hymenoptera: Megachilidae Megachile sculpturalis Smith Size: about 0.75 inch (1 individual brood cells in an existing tube or cavity using wood particles and mud. The female provisions each is based on discouraging carpenter bees from nesting in wood by painting the surface of the wood. Existing

Liskiewicz, Maciej

141

What's Driving Oil Prices? James L. Smith  

E-print Network

1 What's Driving Oil Prices? James L. Smith Cary M. Maguire Chair in Oil & Gas Management Critical Issues in Energy Federal Reserve Bank of Dallas November 2, 2006 The Price of OPEC Oil ($/bbl) $0 $20 $40 $60 $80 1970 1975 1980 1985 1990 1995 2000 2005 Real Price ($2005) #12;2 Hubbert's Curve (Peak Oil

O'Donnell, Tom

142

Catherine L. Smith ALL RIGHTS RESERVED  

E-print Network

; thank you for your love, which has carried the day on many occasions. My sons Joseph, William2010 Catherine L. Smith ALL RIGHTS RESERVED #12;ADAPTIVE SEARCH BEHAVIOR: A RESPONSE TO QUERY an interactive search system returns a results list that fails to meet its user's information need, the user

143

THE BREEDING BIOLOGY OF SMITH'S LONGSPUR  

Microsoft Academic Search

INCE 1930, when the railroad connecting the Canadian prairies with the port of Churchill, Manitoba, on Hudson Bay, was completed, the Churchill area has been the scene of many ornithological investigations. Despite this, many of the region's most interesting birds have remained virtually unstudied. One of these is Smith's Longspur (Calcarius pictus) . Our present knowledge of this species on

JOSEPH R. JEIIL. JR

144

Multivariable Smith Predictors Design for Nonsquare Plants  

Microsoft Academic Search

The goal of this brief is to provide a solution to the optimal design problem of decoupled multivariable Smith Predictor for general linear stable plants with multiple time delays. The design procedure is divided into three steps. In the first step, a nonsquare plant is factored into the \\

Weidong Zhang; Chen Lin

2006-01-01

145

Is the Cerebellum a Smith Predictor?  

Microsoft Academic Search

The motor system may use internal predictive models of the motor apparatus to achieve better control than would be possible by negative feedback. Several theories have proposed that the cerebellum may form these predictive representations. In this article, we review these theories and try to unify them by reference to an engineering control model known as a Smith Predictor. We

R. C. Miall; D. J. Weir; D. M. Wolpert; J. F. Stein

1993-01-01

146

Neuromorphic Systems: past, present and future Leslie S. Smith  

E-print Network

Neuromorphic Systems: past, present and future Leslie S. Smith Abstract Neuromorphic systems://en.wikipedia.org/wiki/Neuromorphic) the term was coined by Carver Mead (see below), in the late 1980's, but the ideas Leslie S. Smith #12;2 Leslie S. Smith have roots that go back well before this. The idea of an equivalent circuit

Smith, Leslie S.

147

EIGENVALUES AND THE SMITH NORMAL FORM Joseph J. Rushanan  

E-print Network

EIGENVALUES AND THE SMITH NORMAL FORM Joseph J. Rushanan The MITRE Corporation, M/S E025, Bedford, MA 01730 Abstract. Results are shown that compare the Smith Normal Form (SNF) over the integers and its Smith Normal Form (SNF) over the integers. Our goals are more general than those results

Rushanan, Joe J.

148

Computation of Hermite and Smith Normal Forms of Matrices  

E-print Network

Computation of Hermite and Smith Normal Forms of Matrices by Arne Storjohann A thesis presented the problem of computing Hermite and Smith normal forms of ma­ trices over principal ideal domains. The main probabilistic algorithm to compute the Smith normal form of a polynomial matrix for those cases where pre

Storjohann, Arne

149

SMITH FARM FROM CEMETERY HILL, LOOKING SOUTHWEST. (This image shows ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

SMITH FARM FROM CEMETERY HILL, LOOKING SOUTHWEST. (This image shows the Smith Farm in the center of Ebey?s Prairie. Ebey?s Landing and the Puget Sound can be seen on the right. Farmers from the Sherman-Bishop Dairy are visible at the bottom left, cutting hay.) - Smith Farm, 399 Ebey Road, Coupeville, Island County, WA

150

SMITH AND BARGHNONCONSCIOUS EFFECTS OF POWER NONCONSCIOUS EFFECTS OF POWER  

E-print Network

SMITH AND BARGHNONCONSCIOUS EFFECTS OF POWER NONCONSCIOUS EFFECTS OF POWER ON BASIC APPROACH AND AVOIDANCE TENDENCIES Pamela K. Smith Radboud University Nijmegen John A. Bargh Yale University According-24 Address for correspondence: Pamela K. Smith, Department of Social Psychology, Behavioural Science

Bargh, John A.

151

Extended Response to Weir and Smith Sven E. Wilson  

E-print Network

Extended Response to Weir and Smith Sven E. Wilson Brigham Young University Benjamin L. Howell University Phone: (801) 422-9018 Email: sven@byu.edu #12;2 Abstract Evidence provided by Weir and Smith and a variety of regression models (including that of Weir and Smith). In particular, our pooled regression

Martinez, Tony R.

152

Smith & Telang/Competing with Free RESEARCH ARTICLE  

E-print Network

Smith & Telang/Competing with Free RESEARCH ARTICLE COMPETING WITH FREE: THE IMPACT OF MOVIE BROADCASTS ON DVD SALES AND INTERNET PIRACY 1 By: Michael D. Smith H. John Heinz III School of Public Policy. 321-338/June 2009 321 #12;Smith & Telang/Competing with Free Introduction "We can't compete with free

Sadeh, Norman M.

153

Using Gazetteers in Discriminative Information Extraction Andrew Smith  

E-print Network

Using Gazetteers in Discriminative Information Extraction Andrew Smith Division of Informatics University of Edinburgh United Kingdom a.p.smith-2@sms.ed.ac.uk Miles Osborne Division of Informatics model, then decoding using a logarithmic opinion pool (Smith et al., 2005), we may achieve much higher

Osborne, Miles

154

Generating and Interpreting Referring Expressions in Dustin Arthur Smith  

E-print Network

Generating and Interpreting Referring Expressions in Context by Dustin Arthur Smith B.S., Wake Referring Expressions in Context by Dustin Arthur Smith Submitted to the Program of Media Arts and Sciences, MIT Media Lab #12;Generating and Interpreting Referring Expressions in Context by Dustin Arthur Smith

155

Computation of Hermite and Smith Normal Forms of Matrices  

E-print Network

Computation of Hermite and Smith Normal Forms of Matrices; Abstract We study the problem of computing Hermite and Smith normal forms of ma- trices over. One first result is a fast Las Vegas probabilistic algorithm to compute the * *Smith normal form

Storjohann, Arne

156

Dorothy Blakey Smith Compiled by April Haddad (1980)  

E-print Network

Dorothy Blakey Smith fonds Compiled by April Haddad (1980) Last revised October 2012 University (UBC Library catalogue) #12;Fonds Description Dorothy Blakey Smith fonds. ­ 1919-1978. 72 cm of textual records. 78 photographs. Biographical Sketch Born in Leeds, England, Dorothy Blakey Smith immigrated

Handy, Todd C.

157

Numerical algorithms for the computation of the Smith normal  

E-print Network

Numerical algorithms for the computation of the Smith normal form of integral matrices C of the Smith normal form of integral matrices are described. More specifically, the com­ pound matrix method of the algorithms. AMS Subject Classification: Primary 65F30, Secondary 15A21, 15A36. Key words and phrases: Smith

Seberry, Jennifer

158

Tanya M. Smith Department of Human Evolutionary Biology  

E-print Network

1 Tanya M. Smith Department of Human Evolutionary Biology Harvard University 11 Divinity Avenue Research Grant, 1995. Peer-Reviewed Publications 56. Le Cabec, A., Smith, T.M., Tang, N. Tafforeau, P. (in, E., Kunimatsu, Y., Hirasaki, E., Shimizu, D., Smith, T.M. (in review). Ecological signals in molar

Smith, Tanya M.

159

L.C. SMITH COLLEGE OF ENGINEERING AND COMPUTER SCIENCE  

E-print Network

L.C. SMITH COLLEGE OF ENGINEERING AND COMPUTER SCIENCE DEPARTMENT OF CIVIL AND ENVIRONMENTAL departments within the L.C. Smith College of Engineering and Computer Science (LCS). The department has a long and Environmental Engineering have access to a wide variety of computer facilities. The L.C. Smith College

Mohan, Chilukuri K.

160

Michael Smith Compiled by Christopher Hives (2001, 2005)  

E-print Network

Michael Smith fonds Compiled by Christopher Hives (2001, 2005) University of British Columbia File List Catalogue entry (UBC Library catalogue) #12;Fonds Description Michael Smith fonds. ­ 1957 University of British Columbia faculty member and Nobel prize winner Michael Smith (1932-2000) was born

Handy, Todd C.

161

Evolutionary Ecology Research, 2001, 3: 595602 2001 Felisa A. Smith  

E-print Network

Evolutionary Ecology Research, 2001, 3: 595­602 © 2001 Felisa A. Smith Fitness trade-offs select for semelparous reproduction in an extreme environment Felisa A. Smith* and Eric L. Charnov Department of Biology@unm.edu Consult the copyright statement on the inside front cover for non-commercial copying policies. #12;Smith

Smith, Felisa A.

162

RESEARCH ARTICLE Matthew W. Bettridge Barton L. Smith  

E-print Network

RESEARCH ARTICLE Matthew W. Bettridge Ã? Barton L. Smith Robert E. Spall Aerodynamic jet steering of the suction flow is entrained. Vectoring with multiple suction and blowing slots was reported by Smith et al was investigated experimentally by Smith and Glezer (2002) and numerically by Guo et al. (2002, 2003). Synthetic

Smith, Barton L.

163

Mathematics of Games and Politics Instructor: Sam Smith, Mathematics  

E-print Network

Math 132 Mathematics of Games and Politics Syllabus Fall 2010 Instructor: Sam Smith, Mathematics Office Barbelin 212, 610-660-1559, smith@sju.edu Office Hours: Mon 11:30-1:00, Tue 1:00-4:00 or by appointment. Text: Sam Smith, The Mathematics of Games and Politics, available for purchase at the University

Smith, Sam

164

WaveCurrent Interactions in Finite Depth JEROME A. SMITH  

E-print Network

Wave­Current Interactions in Finite Depth JEROME A. SMITH Scripps Institution of Oceanography, La (Longuet-Higgins 1969; Hasselmann 1971; Garrett and Smith 1976; and many others). In particular, Hassel) changes in wave momentum that absorb some of the radiation stress gradients. Garrett and Smith (1976

Smith, Jerome A.

165

Tanya M. Smith Department of Human Evolutionary Biology  

E-print Network

1 Tanya M. Smith Department of Human Evolutionary Biology Harvard University 11 Divinity Avenue Foundation Research Grant, 1995. Peer-Reviewed Publications 55. Le Cabec, A., Smith, T.M., Tafforeau, P. (in., Reid, D.J., Larsen, C.S., Hutchinson, D., Smith, T.M. (in review) Chronology of linear enamel

Smith, Tanya M.

166

Tanya M. Smith Department of Human Evolutionary Biology  

E-print Network

1 Tanya M. Smith Department of Human Evolutionary Biology Harvard University 11 Divinity Avenue. * SUNY Geneseo Foundation Research Grant, 1995. #12;2 Peer-Reviewed Publications 52. Smith, T.M. (in., Stinespring Harris, A., Reid, D.J., Larsen, C.S., Hutchinson, D., Smith, T.M. (in review) Chronology of linear

Smith, Tanya M.

167

Wunderlich, Kaufman, and Smith LINK TRAVEL TIME PREDICTION FOR  

E-print Network

Wunderlich, Kaufman, and Smith 1 LINK TRAVEL TIME PREDICTION FOR DECENTRALIZED ROUTE GUIDANCE@att.com Robert L. Smith University of Michigan Department of Industrial and Operations Engineering Ann Arbor, MI-dating process is utilized to insure the discovery of a stable #12;Wunderlich, Kaufman, and Smith 2 routing after

Smith, Robert L.

168

Tanya M. Smith Department of Human Evolutionary Biology  

E-print Network

1 Tanya M. Smith Department of Human Evolutionary Biology Peabody Museum 47 11 Divinity Avenue, D.J., Larsen, C.S., Hutchinson, D., Smith, T.M. (in review) Chronology of linear enamel hypoplasia.) The Krapina Teeth. Croatian Natural History Museum, Zagreb. #12;2 49. Smith, T.M., Alemseged, Z. (in press

Smith, Tanya M.

169

Deborah K. Smith Department of Geology and Geophysics, MS 22  

E-print Network

Deborah K. Smith Department of Geology and Geophysics, MS 22 Woods Hole Oceanographic Institution: Jordan, T. H., H. W. Menard, and D.K. Smith, Density and size distribution of seamounts in the eastern. Smith, H. W. Menard, J. A. Orcutt and T. H. Jordan, Seismic reflection site survey: correlation

Smith, Deborah K.

170

Rodney K. Smith Award The Rodney K. Smith Award is the highest service award given by the Dean of The University of  

E-print Network

Rodney K. Smith Award The Rodney K. Smith Award is the highest service award given by the Dean of time in one year. Dean Kevin H. Smith explains, "Professor Rodney Smith was a colleague of mine.e., assisting with a visa application or preventing human trafficking). I believe Professor Smith would find

Dasgupta, Dipankar

171

The Smith-Lemli-Opitz syndrome  

PubMed Central

The Smith-Lemli-Opitz syndrome (SLOS) is one of the archetypical multiple congenital malformation syndromes. The recent discovery of the biochemical cause of SLOS and the subsequent redefinition of SLOS as an inborn error of cholesterol metabolism have led to important new treatment possibilities for affected patients. Moreover, the recent recognition of the important role of cholesterol in vertebrate embryogenesis, especially with regard to the hedgehog embryonic signalling pathway and its effects on the expression of homeobox genes, has provided an explanation for the abnormal morphogenesis in the syndrome. The well known role of cholesterol in the formation of steroid hormones has also provided a possible explanation for the abnormal behavioural characteristics of SLOS.???Keywords: Smith-Lemli-Opitz syndrome; cholesterol metabolism; 7-dehydrocholesterol reductase; clinical history; management PMID:10807690

Kelley, R.; Hennekam, R.

2000-01-01

172

Smith Newton Vehicle Performance Evaluation (Brochure)  

SciTech Connect

The Fleet Test and Evaluation Team at the U.S. Department of Energy's National Renewable Energy Laboratory is evaluating and documenting the performance of electric and plug-in hybrid electric drive systems in medium-duty trucks across the nation. Through this project, Smith Electric Vehicles will build and deploy 500 all-electric medium-duty trucks. The trucks will be deployed in diverse climates across the country.

Not Available

2012-08-01

173

On the delay sensitivity of Smith Predictors  

Microsoft Academic Search

It is well known that the stability of the Smith Predictor control scheme is sensitive with respect to delay uncertainties. We analysed the effect of delay mismatches on the closed-loop stability and derived various stability\\/instability characterizations. Thereby, it was assumed that the desired closed-loop transfer function was proper but not necessarily strictly proper. This may induce a sensitivity of stability

W. Michiels; S.-I. Niculescu

2003-01-01

174

Nonlinear neural controller with neural Smith predictor  

Microsoft Academic Search

This paper proposes a new nonlinear neural controller with a neural Smith predictor for time-delay compensation of nonlinear\\u000a processes. Similar to the conventional linear PID controller, the nonlinear neural network based controller uses the system\\u000a error, the integral of the system error, and the derivative of the system error as its inputs but the mapping from the inputs\\u000a to the

Yonghong Tan; Achiel Van Cauwenberghe

1994-01-01

175

The Smith Cloud: Galactic or Extragalactic?  

NASA Astrophysics Data System (ADS)

The Milky Way is surrounded by a population of gaseous high-velocity clouds (HVCs), which play an important role in bringing fresh fuel for star formation into the disk. The Smith Cloud is an HVC in an advanced state of accretion, only ~30 Myr away from impacting the Galactic plane. It is unique among HVCs in having a known distance (12.4 kpc) and a well-constrained 3D velocity (300 km/s), but we do not yet know its metallicity, which would distinguish between Galactic (metal-enriched) and extragalactic (metal-poor) origins. Here we propose a program to measure the Smith Cloud's metallicity using HST/COS spectra of three AGN lying behind the Cloud and its wake. Combining the UV metal-line (O I and S II) column densities with existing H I column densities will lead to precise abundance measurements for the Smith Cloud, directly constraining its origin. In addition, the relative strength of depleted (Fe II, Si II) to undepleted (S II) UV absorption lines will be used to infer its dust content. Finally, we will search for variation in the ionization level and kinematics between the three sight lines, which would indicate a disruptive encounter with the hot Galactic corona.

Fox, Andrew

2014-10-01

176

Risking Connection Across Difference: Reply to Sokal and Smith1  

E-print Network

's Beyond the Hoax: Science, Philosophy, and Culture (2008), and Barbara Herrnstein Smith's Scandalous: ``Thus, Bacon stands accused of analogizing systematic experimentation to the rape (Harding) and torture

Sokal, Alan

177

Constructions of identity in Zadie Smith's "On beauty".  

E-print Network

??Zadie Smith ist eine der bekanntesten britischen Nachwuchsautorinnen und erreichte mit ihrem im Jahr 2000 erschienenen Erstlingswerk White Teeth internationale Bekanntheit. Mittlerweile hat die junge… (more)

Krickl, Heidemarie

2009-01-01

178

A review of "Andrew Marvell: The Chameleon" by Nigel Smith  

E-print Network

of that Donne, however, readers will need to turn elsewhere. Nigel Smith. Andrew Marvell: #31;e Chameleon. Yale University Press, 2010. xiv + 400 pp. $45.00. Review by #25; #30;#5; #8;#25;#31;#8;#25;#27;#18;#8;#20;, #25;#29;#26;#19;#18;#27; #24;#20; #30...;#8;#30;. ?Chime? is a word much in evidence in Marvell studies these days (rhyme words chime with each other, as do authors, subject matters, intertexts, contexts), and Nigel Smith?s new biography chimes in with genial intelligence and erudition. Smith...

Garganigo, Alex

2012-01-01

179

Breeding productivity of Smith Island black ducks  

USGS Publications Warehouse

We investigated the breeding performance of American black ducks (Anas rubripes) on Smith Island, Chesapeake Bay, to improve our understanding of island black duck breeding ecology and to make management recommendations to enhance productivity. During 1995-96, we implanted 56 female black ducks with 20-g radio transmitters and tracked 35 of the individuals through the breeding season to locate nests, determine nest fate, and identify brood habitat. We also increased preseason banding efforts and compared capture characteristics over 12 years with those from the Deal Island Wildlife Management Area, a banding site on the mainland of Tangier Sound. A low rate of nesting (37%), lack of renesting, and poor hatching success (31%) indicated that island salt marsh habitats present a harsh environment for breeding black ducks. Black ducks located 11 of 13 nests (85%) in black needlerush (Juncus roemerianus) marsh where they were vulnerable to flooding from extreme tides and to egg predators. No nests were found on forested tree hammocks, a feature that distinguishes Smith Island from nearby South Marsh and Bloodsworth Islands. Nest predators included red foxes (Vulpes vulpes), herring gulls (Larus argentams), fish crows (Corvus ossifragus), and, potentially, Norway rats (Rattus norvegicus). Unlike mainland red foxes, foxes radio tracked on Smith Island were found to be capable swimmers and effective low marsh predators. We found shoreline meadows of widgeon grass (Ruppia maritima) to be important foraging sites for black ducks and suspected that the virtual absence of fresh water in this high salinity environment (1217+ ppt) to incur some cost in terms of growth and survival of ducklings. Preseason bandings revealed a high proportion of banded adults and a strong positive correlation in age ratios with the Deal Island banding site. This latter finding strongly suggests a negative universal effect of storm tides on nest success for Tangier Sound black ducks. Management to reduce nest predators, especially gulls and foxes, likely will have the greatest immediate benefit for island breeding black ducks.

Haramis, G.M.; Jorde, D.G.; Olsen, G.H.; Stotts, D.B.; Harrison, M.K.

2002-01-01

180

Rodney K. Smith Award The Rodney K. Smith Award is the highest service award given by the Dean of the University of  

E-print Network

Rodney K. Smith Award The Rodney K. Smith Award is the highest service award given by the Dean. Humphreys School of Law, Rodney K. Smith's interest in, and respect for, public service was not limited trafficking). Interim Dean William P. Kratzke explains, "I knew Professor Rodney Smith when he was a faculty

Memphis, University of

181

Oscar F. Smith Middle School: One Extra Degree  

ERIC Educational Resources Information Center

This article features Oscar F. Smith Middle School, a challenging school in Chesapeake, Virginia. When Principal Linda Scott exclaims, "Oscar F. Smith Middle School is "hot"!" to visitors, she is not referring to the inside temperature of the bustling school of grades 6-8 located in the historic South Norfolk borough of Chesapeake. She is…

Principal Leadership, 2012

2012-01-01

182

(Mis)Representing Underachievement: A Rejoinder to Gorard and Smith  

ERIC Educational Resources Information Center

This article provides a brief rejoinder to Gorard and Smith's reply to an article I published in a previous issue of British Journal of Sociology of Education. In that original article I provided a critical review of their quantitative research on gender and education in the United Kingdom. In their reply to this article, Gorard and Smith seem to…

Connolly, Paul

2008-01-01

183

Author! Author! The Gallant Children's Author: Dick King-Smith  

ERIC Educational Resources Information Center

This column presents a brief biography of Dick King-Smith. Born on March 27, 1922 and raised in Gloucestershire, England, he grew up with animals of all kinds. King-Smith was a farmer for twenty years and then became a school teacher. He was also a soldier during wartime, a traveling salesman, shoe factory worker, and television presenter. He…

Brodie, Carolyn S.

2005-01-01

184

Father Knows Best: Using Adam Smith to Teach Transactions Costs  

ERIC Educational Resources Information Center

Adam Smith's moral philosophy can be used to introduce economics students to the important idea of transactions costs. The author provides a brief background in this article to Smith's moral philosophy and connects it to the costs of transacting in a way that fits easily into the standard principles of microeconomics classroom. By doing…

Dupont, Brandon

2014-01-01

185

Smith-Lemli-Opitz Syndrome: A Case with Annular Pancreas  

PubMed Central

Smith-Lemli-Opitz syndrome is an autosomal recessive disease of cholesterol metabolism. It is a multiple malformation syndrome with typical dysmorphic features such as bitemporal narrowing, ptosis, epicanthus, microcephaly, micrognathia, and cardiovascular, skeletal, urogenital, and gastrointestinal anomalies. This report presents a typical case of Smith-Lemli-Opitz syndrome with annular pancreas which is an unreported gastrointestinal abnormality. PMID:25165593

Demirdoven, Mehmet; Yazgan, Hamza; Korkmaz, Mevlit; Gebesce, Arzu; Tonbul, Alparslan

2014-01-01

186

Performance-Driven Development Michael J. A. Smith  

E-print Network

the average developer to think about performance, and you might as well ask them in Chinese. ExceptPerformance-Driven Development Michael J. A. Smith M.J.A.Smith@sms.ed.ac.uk Introduction Ask for in a few specialised areas, there is a general culture of "write first, optimise later." This is worrying

Narasayya, Vivek

187

CURRICULUM VITAE -RYAN H SMITH Atlantic Oceanographic and Meteorological Laboratory  

E-print Network

CURRICULUM VITAE - RYAN H SMITH Atlantic Oceanographic and Meteorological Laboratory National Oceanic and Atmospheric Administration 4301 Rickenbacker Causeway Miami, FL 33149 PERSONAL: Name: Ryan) 361-4328 Fax: (305) 361-4392 Email: ryan.smith@noaa.gov INTERESTS: Regional circulation of south

188

Modified Smith predictor design for periodic disturbance rejection  

Microsoft Academic Search

In this paper, a modified Smith predictor control scheme is proposed for periodic disturbance rejection in both stable and unstable processes with time delay. Without affecting the superior setpoint response of Smith predictor control, the regulation performance under periodic disturbance can be enhanced significantly by the proposed design. Meanwhile, the asymptotical rejection for non-periodic disturbance will also be improved. Internal

Han-Qin Zhou; Qing-Guo Wang; Liu Min

2007-01-01

189

Neural network-based teleoperation using Smith predictors  

Microsoft Academic Search

The introduction of communication channel tune delay and environment dynamic uncertainties create a significant challenge in the design of stable transparent bilateral teleoperation controllers. An early control methodology for time delayed systems, which is applicable to teleoperation systems is the use of Smith predictors. Recently a few Smith predictor based teleoperation control architectures have been proposed for 2-channel teleoperation systems

Andrew C. Smith; Keyvan Hashtrudi-Zaad

2005-01-01

190

Smith predictor control and internal model control - a tutorial  

Microsoft Academic Search

This paper is to provide a guide to the time-delay compensation scheme known as Smith predictor control which uses feedback loop for controlling any system. The Smith predictor control was devised to remove the delay effect from the closed-loop design, and is equivalent to IMC in the sense that the delayed behavior of the plant is cancelled by the plant

N. Abe; K. Yamanaka

2003-01-01

191

experiment actually sees," Smith says. "When we were  

E-print Network

in science depend on atoms and molecules moving," Smith says. "We want to create movies of molecules supercomputer simulations and experimental results closer together by identifying common "fingerprints." ORNL's motions at low resolution," says Smith, who directs ORNL's Center for Molecular Biophysics and holds

Pennycook, Steve

192

Review of the Solar Array Telescopes David A. Smith  

E-print Network

Review of the Solar Array Telescopes David A. Smith Centre d'Etudes Nucl´eaires de Bordeaux, described as an `Arizona mesa' in the text. 68 #12;Review of the Solar Array Telescopes David A. Smith 2 Wavefront Sampling with Solar Mirror Arrays 2.1 The ABC's Figure 1 illustrates the principle of a solar

Paris-Sud XI, Université de

193

Footedness in world soccer: an analysis of France '98 DAVID P. CAREY,* GEOFF SMITH, DANIEL T. SMITH, JOHN W. SHEPHERD,  

E-print Network

is apparent given the nature of the sport. Soccer players must be able to kick a ball with either foot' (PoracFootedness in world soccer: an analysis of France '98 DAVID P. CAREY,* GEOFF SMITH, DANIEL T. SMITH of foot preference and performance, as well as demonstrating the usefulness of soccer for studies

Aberdeen, University of

194

Sophia Smith Collection: Voices of Feminism  

NSDL National Science Digital Library

Based at Smith College, the Voices of Feminism Oral History Project "documents the persistence and diversity of organizing for women in the United States in the latter half of the 20th century." The women interviewed here include labor, peace, and anti-racism activists, along with anti-poverty organizers and lesbian rights advocates. The project was funded by the Ford Foundation from 2002 to 2008, and visitors will find that they can also read transcripts of the interviews as well. The "Narrators" page features biographical profiles of each interviewee, along with links to the transcript of each interview. As a bonus feature, there are video excerpts for six of the women interviewed as part of the project.

195

Trinucleotide repeat expansion and DRPLA (Smith`s disease): Molecular characterization of atrophin-1  

SciTech Connect

Smith`s disease (also known as dentatorubral pallidoluysian atrophy or DRPLA) is a rare, progressive, fatal neuropsychiatric disorder similar to Huntington`s disease (HD). Smith`s disease is characterized by ataxia, choreoathetosis, myoclonic epilepsy, dementia, and genetic anticipation. Neuropathological findings include prominent cell loss in the dentate nucleus of the cerebellum, the globus pallidus, the red nucleus, and the subthalamic nucleus. An expansion of a CAG trinucleotide repeat encoding polyglutamine in a gene originally identified in our laboratory as part of a program to clone candidate genes for disorders with anticipation has recently been found to cause this disorder. We have identified two families that demonstrate the pathological and genetic features (expanded CAG repeat and anticipation) of this disease. Northern analysis indicates that the gene, which we have termed atrophin-1, is widely expressed as a 5 kb mRNA in normal human brain and peripheral tissues. Brain expression is highest in the cerebellum. The developmental expression of the rat homologues of IT-15 (the gene in which a CAG expansion causes HD) and atrophin-1 were compared. Atrophin-1 was most highly expressed in early rat embryo brain (E16), whereas the greatest expression of IT-15 was in the adult rat brain. Cloning and sequencing of the open reading frame from inserts contained in brain cDNA libraries is in progress. In addition to the CAG repeat, the ORF contains an unusual region of alternating acidic and basic amino acids. Further characterization of atrophin-1, and comparison of it to other genes in which trinucleotide repeat expansion leads to neuropsychiatric disorders, should lead to a better understanding of the pathophysiology by which CAG repeat expansion causes human disease.

Margolis, R.L.; Li, S.H.; Li, X.J.; Ross, C.A. [Johns Hopkins Univ., Balitmore, MD (United States)

1994-09-01

196

Theory and Design of Smith-Purcell Semiconductor Terahertz Sources  

E-print Network

of the Smith-Purcell effect is called stimulated SPR, and it the physical radiation mechanism used in certain types of free-electron lasers. In fact, the first high-power Smith-Purcell device – called the orotron – first introduced by Rusin in 1965 was later... shown to be the first free-electron laser. [56] The Smith-Purcell semiconductor THz source described in this work can conceptually be considered as a ‘solid-state orotron’, although the detailed operation of the devices differ radically since the orotron...

Smith, Don DeeWayne

2013-12-06

197

THE ROSENZWEIG-MACARTHUR PREDATOR-PREY HAL L. SMITH*  

E-print Network

THE ROSENZWEIG-MACARTHUR PREDATOR-PREY MODEL HAL L. SMITH* SCHOOL OF MATHEMATICAL AND STATISTICAL. It is the per predator kill rate. 1 #12;2 H.L. Smith 0 0.5 1 1.5 2 2.5 3 3.5 0 0.2 0.4 0.6 0.8 1 1.2 1.4 1.6 1 that solutions are bounded in the future and therefore are defined for all t 0. #12;4 H.L. Smith Notice that 2

Smith, Hal

198

A Design Method for Smith Predictors for Minimum-Phase Time-Delay Plants  

Microsoft Academic Search

In this paper, we examine a design method for a modified Smith predictor for minimum-phase time- delay plants. The modified Smith predictor is well known as an eective time-delay compensator for a plant with large time delays, and several papers on the modified Smith predictor have been published. However, the parameterization of all stabilizing mod- ified Smith predictors has not

Kou Yamada; Nobuaki Matsushima

2005-01-01

199

35. VIEW OF HOWLAND HILL ROAD, JEDEDIAH SMITH STATE PARK. ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

35. VIEW OF HOWLAND HILL ROAD, JEDEDIAH SMITH STATE PARK. CRESCENT CITY, DEL NORTE COUNTY, CALIFORNIA. LOOKING E. - Redwood National & State Parks Roads, California coast from Crescent City to Trinidad, Crescent City, Del Norte County, CA

200

VIEW OF HOWLAND HILL ROAD, JEDEDIAH SMITH STATE PARK. CRESCENT ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

VIEW OF HOWLAND HILL ROAD, JEDEDIAH SMITH STATE PARK. CRESCENT CITY, DEL NORTE COUNTY, CALIFORNIA. LOOKING W. - Redwood National & State Parks Roads, California coast from Crescent City to Trinidad, Crescent City, Del Norte County, CA

201

VIEW OF HOWLAND HILL ROAD, JEDEDIAH SMITH STATE PARK. CRESCENT ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

VIEW OF HOWLAND HILL ROAD, JEDEDIAH SMITH STATE PARK. CRESCENT CITY, DEL NORTE COUNTY, CALIFORNIA. LOOKING E. - Redwood National & State Parks Roads, California coast from Crescent City to Trinidad, Crescent City, Del Norte County, CA

202

VIEW OF HOWLAND HILL ROAD, JEDEDIAH SMITH STATE PARK. CRESCENT ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

VIEW OF HOWLAND HILL ROAD, JEDEDIAH SMITH STATE PARK. CRESCENT CITY, DEL NORTH COUNTY, CALIFORNIA. LOOKING ESE. - Redwood National & State Parks Roads, California coast from Crescent City to Trinidad, Crescent City, Del Norte County, CA

203

MORTALITY ESTIMATES FROM SIZE DISTRIBUTIONS: A CRITIQUE OF SMITH'S MODEL  

EPA Science Inventory

Smith (1972) described a method of computing mortality rates from growth and size-frequency data for a population which meets several assumptions. (Copyright (c) 1977 by The American Society of Limnology and Oceanography, Inc.)...

204

AND REPORT ON AN INVESTIGATION OF BY HUGH M. SMITH,  

E-print Network

of tho lake fisheries ; the New York legislature has provided for a nev code of fishery laws with a view, compiled by Hugh M. Smith and Mermin- 80, pp.Marie Snell, with introduction onddesaription of fishing

205

37. BRIDGE 115, SMITH RIVER MIDDLE FORK OREGON STATE HIGHWAY ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

37. BRIDGE 1-15, SMITH RIVER MIDDLE FORK OREGON STATE HIGHWAY 199. JOSEPHINE COUNTY, OREGON. LOOKING SSW. - Redwood National & State Parks Roads, California coast from Crescent City to Trinidad, Crescent City, Del Norte County, CA

206

Smith–Ricardo Specialization in the Presence of Tiring Effects  

Microsoft Academic Search

\\u000a One of the best selling ideas economics ever had was the Smith–Ricardo paradigm of specialization, division of labor, and\\u000a comparative advantage. Adam Smith (1776) wrote almost lyrically about the advantages of specialized pin-making. Through dividing\\u000a the process in many tiny operations, combined with education to very specialized moments, such as polishing the nails, or\\u000a wrapping them in paper, based on

Tonu Puu

207

Smith Predictor Type Control Architectures for Time Delayed Teleoperation  

Microsoft Academic Search

An early control methodology for time delayed plants is the Smith predictor, in which the plant model is utilized to predict the non-delayed output of the plant and move the delay out of the control loop. Recent Smith predictor based teleoperation control architectures have used linear or fixed-parameter dynamic approximations of the slave\\/environment at the master for environment contact prediction.

Andrew C. Smith; Keyvan Hashtrudi-zaad

2006-01-01

208

A new class of Smith predictors for network congestion control  

Microsoft Academic Search

A new class of time-variant Smith predictors for buffer set point control over communication networks is proposed. The new Smith predictor uses two different types of time-variant network delay models, i.e. the forward delay (modeling delay effects on the data stream) and the return delay (modeling delay effects on the buffer occupancy information.) The proposed control scheme tracks the desired

Peter Bauer; Mihail Sichitiu; Russ Ernst; Kamal Premaratne

2001-01-01

209

Edwin Smith Papyrus Case 8: a reappraisal.  

PubMed

There are 3 translations of the Edwin Smith Papyrus: Breasted's (1930), Allen's (2005), and Sanchez and Meltzer's (2012). Case 8 is similarly presented in all 3 translations, although with increasing detail in the later works. The patient in Case 8 had a comminuted skull fracture under intact skin. There were palpable pulsations at the fracture site. There was deviation of the eye on the side of the injury and an ipsilateral spastic hemiparesis in an ambulant patient with bleeding from the nose and ear. Explanations of the paralysis have included a contrecoup lesion and compression of the contralateral cerebral peduncle against the tentorial incisura. Brainstem compression due to herniation is accompanied by loss of consciousness. Extensive contrecoup lesions consistent with the extent of the described paresis would also be associated with probable coma. The paralysis was spastic, but spasticity takes weeks to develop after trauma. Yet this patient's trauma was fresh, as there was still bleeding from the nose and the ear. It is suggested the paresis antedated the trauma, which was not its cause. The reasons for this suggestion are presented in this paper. PMID:24484229

Ganz, Jeremy C

2014-05-01

210

Kiki Smith: Prints, Books & Things at MoMA  

NSDL National Science Digital Library

Using a similar interface to that of Artists of Brücke (German Expressionist prints, reviewed in the December 5, 2003 and Nov.2, 2001 Scout Reports), the Museum of Modern Art (MoMA) presents this major retrospective of the work of Kiki Smith, born in 1954 in Nuremberg, Germany. Smith is the daughter of American sculptor Tony Smith, and her first experience with art was helping her father make cardboard models for his geometric sculptures. She is thought of as a sculptor and builder of installations, but since the 1980s, has created an extensive body of printed works, 135 of which are gathered in this web exhibition. Like the Expressionist show, the Smith show features a virtual light table of images that can be arranged dynamically by Themes -- early screen prints, anatomy, self-portraits, nature, feminine contexts -- or Mediums. In recent years, Smith has worked on etchings pulled from plates of monumental size, roughly 4 feet by 6 feet, such as a series based on Lewis Carroll, including Pool of Tears 2 (2000) and Come Away from Her (2003). The site also includes a chronology of Smith's life and a 35-page essay by Wendy Weitman, MoMA's Curator of Prints and illustrated Books.

211

Smith's rent gap theory and local real estate dynamics: A multi-agent model  

Microsoft Academic Search

The aim of this paper is to investigate local housing market dynamics by applying an urban spatial model of gentrification based on Smith’s rent gap theory [Smith, N. (1979). Toward a theory of gentrification: a back to the city movement by capital, not people. APA Journal, 538–548]. Smith’s supply side approach explains the emergence of gentrifying neighbourhoods on the basis

Lidia Diappi; Paola Bolchi

2008-01-01

212

Getting physical in drug discovery II: the impact of chromatographic hydrophobicity measurements and aromaticity.  

PubMed

Here, we review the performance of chromatographic hydrophobicity measurements in a data set of 100,000 GlaxoSmithKline compounds, demonstrating the advantages of the method over octanol-water partitioning and highlighting new insights for drug discovery. The value of chromatographic measurements, versus other hydrophobicity estimates, was supported by improved relationships with solubility, permeation, cytochrome P450s, intrinsic clearance, hERG binding and promiscuity. We also observed marked differentiation of the relative influence of intrinsic and effective hydrophobicity. The summing of hydrophobicity values plus aromatic ring count [logD(pH7.4) (or logP)+#Ar], indicated a wide relevance for simplistic 'property forecast indices' in developability assays, clearly enhanced by chromatographic values; therefore establishing new foundations for enriching property-based drug design. PMID:21704184

Young, Robert J; Green, Darren V S; Luscombe, Christopher N; Hill, Alan P

2011-09-01

213

OOMMPPAA: A Tool To Aid Directed Synthesis by the Combined Analysis of Activity and Structural Data.  

PubMed

There is an ever increasing resource in terms of both structural information and activity data for many protein targets. In this paper we describe OOMMPPAA, a novel computational tool designed to inform compound design by combining such data. OOMMPPAA uses 3D matched molecular pairs to generate 3D ligand conformations. It then identifies pharmacophoric transformations between pairs of compounds and associates them with their relevant activity changes. OOMMPPAA presents this data in an interactive application providing the user with a visual summary of important interaction regions in the context of the binding site. We present validation of the tool using openly available data for CDK2 and a GlaxoSmithKline data set for a SAM-dependent methyl-transferase. We demonstrate OOMMPPAA's application in optimizing both potency and cell permeability and use OOMMPPAA to highlight nuanced and cross-series SAR. OOMMPPAA is freely available to download at http://oommppaa.sgc.ox.ac.uk/OOMMPPAA/ . PMID:25244105

Bradley, Anthony R; Wall, Ian D; Green, Darren V S; Deane, Charlotte M; Marsden, Brian D

2014-10-27

214

HTS and hit finding in academia – from chemical genomics to drug discovery  

PubMed Central

The liaison between academia and the pharmaceutical industry was originally served primarily through the scientific literature and limited, specific industry–academia partnerships. Some of these partnerships have resulted in drugs on the market, such as Vorinostat (Memorial Sloan-Kettering Cancer Centre and Merck) and Tenofovir (University of Leuven; Institute of Organic Chemistry and Biochemistry, Czech Republic; and GlaxoSmithKline), but the timescales from concept to clinic have, in most cases, taken many decades. We now find ourselves in a world in which the edges between these sectors are more blurred and the establishment and acceptance of high-throughput screening alongside the wider concept of ‘hit discovery’ in academia provides one of the key platforms required to enable this sector to contribute directly to addressing unmet medical need. PMID:19793546

Frearson, Julie A.; Collie, Iain T.

2009-01-01

215

Benchmarks for detecting 'breakthroughs' in clinical trials: empirical assessment of the probability of large treatment effects using kernel density estimation  

PubMed Central

Objective To understand how often ‘breakthroughs,’ that is, treatments that significantly improve health outcomes, can be developed. Design We applied weighted adaptive kernel density estimation to construct the probability density function for observed treatment effects from five publicly funded cohorts and one privately funded group. Data Sources 820 trials involving 1064 comparisons and enrolling 331?004 patients were conducted by five publicly funded cooperative groups. 40 cancer trials involving 50 comparisons and enrolling a total of 19?889 patients were conducted by GlaxoSmithKline. Results We calculated that the probability of detecting treatment with large effects is 10% (5–25%), and that the probability of detecting treatment with very large treatment effects is 2% (0.3–10%). Researchers themselves judged that they discovered a new, breakthrough intervention in 16% of trials. Conclusions We propose these figures as the benchmarks against which future development of ‘breakthrough’ treatments should be measured. PMID:25335959

Miladinovic, Branko; Kumar, Ambuj; Mhaskar, Rahul; Djulbegovic, Benjamin

2014-01-01

216

Development of a commercial Automated Laser Gas Interface (ALGI) for AMS  

NASA Astrophysics Data System (ADS)

National Electrostatics Corporation (NEC), Massachusetts Institute of Technology (MIT), and GlaxoSmithKline (GSK) collectively have been developing an interface to introduce CO2 produced by the laser combustion of liquid chromatograph eluate deposited on a CuO substrate directly into the ion source of an AMS system, thereby bypassing the customary graphitization process. The Automated Laser Gas Interface (ALGI) converts dried liquid samples to CO2 gas quickly and efficiently, allowing 96 samples to be measured in as little as 16 h. 14C:12C ratios stabilize typically within 2 min of analysis time per sample. Presented is the recent progress of NEC’s ALGI, a stand-alone accessory to an NEC gas-enabled multi-cathode source of negative ions by Cs sputtering (MC-SNICS) ion source.

Daniel, R.; Mores, M.; Kitchen, R.; Sundquist, M.; Hauser, T.; Stodola, M.; Tannenbaum, S.; Skipper, P.; Liberman, R.; Young, G.; Corless, S.; Tucker, M.

2013-01-01

217

Use of MenACWY-CRM in adolescents in the United States.  

PubMed

Adolescents constitute a high-risk group for invasive meningococcal disease. MenACWY-CRM (Menveo, Novartis Vaccines, Cambridge, MA) is a quadrivalent meningococcal conjugate vaccine indicated to prevent invasive meningococcal disease caused by Neisseria meningitidis serogroups A, C, W-135, and Y. It has been approved for use in persons age 2-55 years. The tolerability and immunogenicity of MenACWY-CRM in adolescents have been ascertained in phase 2 and 3 trials against MPSV4 (Menomune, sanofi pasteur, Swiftwater, PA), an unconjugated quadrivalent meningococcal vaccine, and MenACWY-D (Menactra, sanofi pasteur), another conjugated quadrivalent meningococcal vaccine. Clinical trials also have demonstrated that MenACWY-CRM is well tolerated and immunogenic when administered to adolescents concomitantly with the combined tetanus, diphtheria, and acellular pertussis vaccine (Boostrix, GlaxoSmithKline Biologicals, Rixensart, Belgium) and the quadrivalent human papillomavirus vaccine (Gardasil, Merck & Co., Inc., Whitehouse Station, NJ). PMID:23299001

Black, Steven; Block, Stan L

2013-03-01

218

Strategies for continuous evaluation of the benefit-risk profile of HPV-16/18-AS04-adjuvanted vaccine.  

PubMed

The HPV types 16/18-AS04-adjuvanted cervical cancer vaccine, Cervarix(®) (HPV-16/18-vaccine, GlaxoSmithKline, Belgium) was first approved in 2007 and is licensed in 134 countries for the prevention of persistent infection, premalignant cervical lesions and cervical cancer caused by oncogenic HPV. Benefit-risk status requires continual re-evaluation as vaccine uptake increases, as the epidemiology of the disease evolves and as new information becomes available. This paper provides an example of benefit-risk considerations and risk-management planning. Evaluation of the benefit-risk of HPV-16/18-vaccine post-licensure includes studies with a range of designs in many countries and in collaboration with national public agencies and regulatory authorities. The strategy to assess benefit versus risk will continue to evolve and adapt to the changing HPV-16/18-vaccine market. PMID:25219284

Angelo, Maria-Genalin; Taylor, Sylvia; Struyf, Frank; Tavares Da Silva, Fernanda; Arellano, Felix; David, Marie-Pierre; Dubin, Gary; Rosillon, Dominique; Baril, Laurence

2014-11-01

219

3-Hydroxy-6,7-dihydropyrimido[2,1-c][1,4]oxazin-4(9H)-ones as new HIV-1 integrase inhibitors WO2011046873 A1.  

PubMed

Since the discovery of raltegravir, the first FDA-approved integrase inhibitor, Merck and other pharmaceutical companies have continued their research programs in order to introduce novel molecules as second generation integrase inhibitors. Elvitegravir (Japan Tobacco/Gilead) and dolutegravir (Shionogi/GlaxoSmithKline) are in advanced stages of clinical development. Bristol-Myers Squibb has developed molecules leading to BMS-707035, which was stopped at the Phase II clinical trial stage. Herein is presented the last patent from this company where, in particular, new 3-hydroxy-6,7-dihydropyrimido[2,1-c][1,4]oxazin-4(9H)-ones are synthesized and their biological properties given. PMID:21974685

Cotelle, Philippe

2011-11-01

220

MAGNETIZED GAS IN THE SMITH HIGH VELOCITY CLOUD  

SciTech Connect

We report the first detection of magnetic fields associated with the Smith High Velocity Cloud. We use a catalog of Faraday rotation measures toward extragalactic radio sources behind the Smith Cloud, new H I observations from the Robert C. Byrd Green Bank Telescope, and a spectroscopic map of H? from the Wisconsin H-Alpha Mapper Northern Sky Survey. There are enhancements in rotation measure (RM) of ?100 rad m{sup –2} which are generally well correlated with decelerated H? emission. We estimate a lower limit on the line-of-sight component of the field of ?8 ?G along a decelerated filament; this is a lower limit due to our assumptions about the geometry. No RM excess is evident in sightlines dominated by H I or H? at the velocity of the Smith Cloud. The smooth H? morphology of the emission at the Smith Cloud velocity suggests photoionization by the Galactic ionizing radiation field as the dominant ionization mechanism, while the filamentary morphology and high (?1 Rayleigh) H? intensity of the lower-velocity magnetized ionized gas suggests an ionization process associated with shocks due to interaction with the Galactic interstellar medium. The presence of the magnetic field may contribute to the survival of high velocity clouds like the Smith Cloud as they move from the Galactic halo to the disk. We expect these data to provide a test for magnetohydrodynamic simulations of infalling gas.

Hill, Alex S.; McClure-Griffiths, Naomi M. [CSIRO Astronomy and Space Science, Marsfield, NSW (Australia); Mao, S. A. [Department of Astronomy, University of Wisconsin-Madison, Madison, WI (United States); Benjamin, Robert A. [Department of Physics, University of Wisconsin-Whitewater, Whitewater, WI (United States); Lockman, Felix J., E-mail: alex.hill@csiro.au, E-mail: naomi.mcclure-griffiths@csiro.au, E-mail: mao@astro.wisc.edu, E-mail: benjamir@uww.edu, E-mail: jlockman@nrao.edu [National Radio Astronomy Observatory, Green Bank, WV (United States)

2013-11-01

221

SR-71 Pilot Rogers E. Smith  

NASA Technical Reports Server (NTRS)

Research pilot Rogers E. Smith is shown here in front of the SR-71 Blackbird he flew for NASA. Rogers was one of the two original NASA research pilots assigned to the SR-71 high speed research program at NASA's Ames-Dryden Flight Research Facility (later, Dryden Flight Research Center, Edwards, California. Smith has been a NASA research pilot at Dryden since 1982. Data from the SR-71 program will be used to aid designers of future supersonic aircraft and propulsion systems. The SR-71 is capable of flying more than 2200 mph (Mach 3+) and at altitudes of over 80,000 feet. Two SR-71 aircraft have been used by NASA as testbeds for high-speed and high-altitude aeronautical research. The aircraft, an SR-71A and an SR-71B pilot trainer aircraft, have been based here at NASA's Dryden Flight Research Center, Edwards, California. They were transferred to NASA after the U.S. Air Force program was cancelled. As research platforms, the aircraft can cruise at Mach 3 for more than one hour. For thermal experiments, this can produce heat soak temperatures of over 600 degrees Fahrenheit (F). This operating environment makes these aircraft excellent platforms to carry out research and experiments in a variety of areas -- aerodynamics, propulsion, structures, thermal protection materials, high-speed and high-temperature instrumentation, atmospheric studies, and sonic boom characterization. The SR-71 was used in a program to study ways of reducing sonic booms or over pressures that are heard on the ground, much like sharp thunderclaps, when an aircraft exceeds the speed of sound. Data from this Sonic Boom Mitigation Study could eventually lead to aircraft designs that would reduce the 'peak' overpressures of sonic booms and minimize the startling affect they produce on the ground. One of the first major experiments to be flown in the NASA SR-71 program was a laser air data collection system. It used laser light instead of air pressure to produce airspeed and attitude reference data, such as angle of attack and sideslip, which are normally obtained with small tubes and vanes extending into the airstream. One of Dryden's SR-71s was used for the Linear Aerospike Rocket Engine, or LASRE Experiment. Another earlier project consisted of a series of flights using the SR-71 as a science camera platform for NASA's Jet Propulsion Laboratory in Pasadena, California. An upward-looking ultraviolet video camera placed in the SR-71's nosebay studied a variety of celestial objects in wavelengths that are blocked to ground-based astronomers. Earlier in its history, Dryden had a decade of past experience at sustained speeds above Mach 3. Two YF-12A aircraft and an SR-71 designated as a YF-12C were flown at the center between December 1969 and November 1979 in a joint NASA/USAF program to learn more about the capabilities and limitations of high-speed, high-altitude flight. The YF-12As were prototypes of a planned interceptor aircraft based on a design that later evolved into the SR-71 reconnaissance aircraft. Dave Lux was the NASA SR-71 project manger for much of the decade of the 1990s, followed by Steve Schmidt. Developed for the USAF as reconnaissance aircraft more than 30 years ago, SR-71s are still the world's fastest and highest-flying production aircraft. The aircraft can fly at speeds of more than 2,200 miles per hour (Mach 3+, or more than three times the speed of sound) and at altitudes of over 85,000 feet. The Lockheed Skunk Works (now Lockheed Martin) built the original SR-71 aircraft. Each aircraft is 107.4 feet long, has a wingspan of 55.6 feet, and is 18.5 feet high (from the ground to the top of the rudders, when parked). Gross takeoff weight is about 140,000 pounds, including a possible fuel weight of 80,280 pounds. The airframes are built almost entirely of titanium and titanium alloys to withstand heat generated by sustained Mach 3 flight. Aerodynamic control surfaces consist of all-moving vertical tail surfaces, ailerons on the outer wings, and elevators on the trailing edges between the engine exhaust nozzles. The two SR-71s at Dryden ha

1992-01-01

222

Smith Predictor Based Control in Teleoperated Image-guided Beating-heart Surgery  

E-print Network

Smith Predictor Based Control in Teleoperated Image-guided Beating-heart Surgery Meaghan Bowthorpe. This research proposes the use of a Smith predictor to compensate for this time delay. The results suggest

223

Dynamic molecular recognition on the surface of vesicle membranes{ Hua Jiang and Bradley D. Smith*  

E-print Network

Dynamic molecular recognition on the surface of vesicle membranes{ Hua Jiang and Bradley D. Smith-mail: smith.115@nd.edu; Fax: 1 574 631 6652; Tel: 1 574 631 8632 { Electronic supplementary information (ESI

Smith, Bradley D.

224

Practical propensity score matching: a reply to Smith and Todd  

Microsoft Academic Search

This paper discusses propensity score matching in the context of Smith and Todd's (Does matching overcome Lalonde's critique of nonexperimental estimators, J. Econom., in press) reanalysis of Dehejia and Wahba (J. Am. Statist. Assoc. 97 (1999) 1053; National Bereau of Economics Research working Paper No. 6829, Rev. Econom. Statist., 2002, forthcoming). Propensity score methods require that a separate propensity score

Rajeev Dehejiaa

225

Variable efficacy of repeated annual influenza vaccination Derek J. Smith,  

E-print Network

Variable efficacy of repeated annual influenza vaccination Derek J. Smith, ¢¡ Stephanie Forrest-665-3493. Running head: Annual influenza vaccination. Classification: Medical Science Keywords: influenza studies. These results have implications for the selection of influenza vaccine strains, and also

Forrest, Stephanie

226

Looking east at canal and R. Paul Smith Power Station. ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Looking east at canal and R. Paul Smith Power Station. The dark trestle at right center carried the spur track to coal unloading facilities located in the space now occupied by the coal pile. - Potomac Edison Company, Chesapeake & Ohio Canal Bridge, Spanning C & O Canal South of U.S. 11, Williamsport, Washington County, MD

227

Smith-Magenis Syndrome: Genetic Basis and Clinical Implications  

ERIC Educational Resources Information Center

Smith-Magenis syndrome (SMS) is a neurobehavioral disorder associated with deletions and mutations of the "RAI1" gene on chromosome 17p11.2. Clinical features of the syndrome include intellectual disability, sleep disturbance, craniofacial differences, and a distinctive profile of stereotypic and self-injurious behaviors. Although the functional…

Finucane, Brenda; Haas-Givler, Barbara

2009-01-01

228

Large Eddy Simulation of a Turbulent Buoyant Helium Philip Smith  

E-print Network

Large Eddy Simulation of a Turbulent Buoyant Helium Plume Philip Smith University of Utah 155 and environmental importance, including fires, subsea and atmospheric exhaust phenomena, gas releases and geothermal and validating simulation tools for numerical techniques such as Large Eddy Simulation (LES) for predictive use

Utah, University of

229

INNER FUNCTIONS IN THE HYPERBOLIC LITTLE BLOCH CLASS Wayne Smith  

E-print Network

for z D. Similarly, f B0, the little Bloch space, if (1 - |z|2 )|f (z)| 0 uniformly as |z| 1INNER FUNCTIONS IN THE HYPERBOLIC LITTLE BLOCH CLASS Wayne Smith Abstract. An analytic function mapping the unit disk into itself is said to belong to the hyperbolic little Bloch class if the ratio (1

Smith, Wayne

230

Alternative Voting Systems in Stock Car Racing Daniel Eric Smith  

E-print Network

Alternative Voting Systems in Stock Car Racing Daniel Eric Smith Mathematics Jacksonville State@jsu.edu Abstract The National Association for Stock Car Auto Racing (NASCAR) is cur- rently the No. 1 spectator of the final placement of each driver in each race. We then construct a set of metrics to determine

Garrett, Aaron

231

Pharmacological Cognitive Enhancers: Comment on Smith and Farah (2011)  

Microsoft Academic Search

Smith and Farah (2011) provided a thought-provoking and perhaps deliberately provocative literature review of the use of stimulants to improve cognitive functioning in humans. They addressed the apparently increasing willingness of individuals mostly in the United States to use stimulants for this purpose and then summarized published literature that explores whether stimulants actually improve specific aspects of neurocognitive function. Although

Glen R. Elliott; Mark D. Elliott

2011-01-01

232

Smith, Hume and the Moral Imagination: Sympathy and Social Justice  

Microsoft Academic Search

In this article, the author argues that there is still much to learn from the moral theories developed by two eminent philosophers, John Smith and David Hume, that can contribute to enhancing the sensibilities of students in classroom discussions about a range of moral and social justice issues. He argues that when school students are afforded the opportunity to imagine

Emery J. Hyslop-Margison

2006-01-01

233

Smith Normal Form a possible basis for an  

E-print Network

. . . . . . . . . . . . . . . . . . . . . . . . . 8 2.5.1 Encoding of RS-codes in DFT domain . . . . . . . . . . . 9 2.6 MIMO systems, Diagonolization Normal Form of Integer Matrices . . . . . . . . . . . . 19 3.3.1 Smith Normal Form of a bigger to decompose a matrix into two unimodular matrices and a diagonal matrix. However, such type of diagonolization

Henkel, Werner

234

TROPHIC DYNAMICS OF STRIPED BASS IN SMITH MOUNTAIN LAKE, VIRGINIA  

EPA Science Inventory

We examined the adequacy of the forage base to meet demand of striped bass in Smith Mountain Lake, Virginia. In regards to prey supply, mean alewife biomass from 1993-1998 was 37 kg/ha and mean gizzard shad biomass from 1990-1997 was 112 kg/ha. Mean annual alewife surplus produ...

235

Karen Smith: Language Arts Educator of the Year  

ERIC Educational Resources Information Center

This article honors Karen Smith, who has been given NCTE's Outstanding Educator in the English Language Arts award for 2009. Through the voices of many colleagues and former students, the article celebrates Karen as a teacher, learner, mentor, collaborator, scholar, storyteller, and visionary thinker and doer.

Hudelson, Sarah

2009-01-01

236

University of Northern British Columbia Dr. Angle Smith  

E-print Network

form of social media. If you are found using laptops or phones for these purposes, you will be asked: angele.smith@unbc.ca Office: #3057 Admin Office Hours: Wednesday 2:30-4:00pm If you need to talk with me planes and highways. � Use and analyze visual media to consider the issues of mobility

Northern British Columbia, University of

237

Functional Food Product Development Jim Smith and Edward Charter  

E-print Network

Functional Food Product Development Edited by Jim Smith and Edward Charter Prince Edward Island Food Technology Centre Charlottetown, Canada A John Wiley & Sons, Ltd., Publication #12;#12;Functional Food Product Development #12;A John Wiley & Sons, Ltd., Publication Functional Food Science

Haddadi, Hamed

238

Obituary: Harding Eugene (Gene) Smith, Jr., 1947-2007  

Microsoft Academic Search

Harding Eugene Smith Junior, or Gene, as he was known to family, friends, and colleagues, passed away after an automobile accident in Encinitas, California, on 16 August 2007. He was 60 years old. Gene had recently retired from UCSD after thirty years of service. A memorial service was held at Quail Botanical Gardens in Encinitas, California, on 23 August 2007.

Carol Lonsdale; Tom Soifer

2009-01-01

239

Philosophy versus Student Need? A Reply to Smith and Hilton.  

ERIC Educational Resources Information Center

This response to Smith and Hilton (1994) suggests that those authors reject philosophical bases for decision making regarding program design for students with mental retardation while actually proposing their own philosophical base for such decision making. The importance of philosophy in guiding decisions and practice over the last several…

Rainforth, Beverly

1994-01-01

240

L.C. Smith College of Engineering and Computer Science  

E-print Network

L.C. Smith College of Engineering and Computer Science DEPARTMENT OF CIVIL AND ENVIRONMENTAL ENGINEERING Graduate Program Profiles for: Master of Science in Civil Engineering Master of Science in Environmental Engineering Master of Science in Environmental Engineering Science Master of Science

Mohan, Chilukuri K.

241

AARON SMITH Department of Agricultural and Resource Economics  

E-print Network

, forthcoming, 2014. "The Environmental Effects of Crop Price Increases: Nitrogen Losses from the U.S. Corn Belt, and Scott Warren), Journal of Sports Economics, 13(6): 603-618, 2012. "Immigration and the US Farm LabourAARON SMITH Department of Agricultural and Resource Economics One Shields Ave, University

California at Davis, University of

242

Reach Survival Estimates, 2008 Bill Muir, Steve Smith, Doug Marsh,  

E-print Network

Reach Survival Estimates, 2008 Bill Muir, Steve Smith, Doug Marsh, John Williams, and Jim FaulknerDalles JohnDay Hells Canyon Oxbow Brownlee Priest Rapids Wanapum Rock Island Rocky Reach Wells Chief Joseph. . Date at McNary Number released McNary to John Day Dam John Day to Bonneville Dam McNary to Bonneville

243

A glossary for stem-cell biology Austin Smith1  

E-print Network

A glossary for stem-cell biology Austin Smith1 Stem-cell biology is in a phase of dynamic expansion exposed to public and political scrutiny. A common language in the stem-cell community is an important tool for coherent exposition to these diverse audiences, not least because certain terms in the stem-cell

Cai, Long

244

A Domain Wall Theory for Ferroelectric Hysteresis Ralph C. Smith  

E-print Network

A Domain Wall Theory for Ferroelectric Hysteresis Ralph C. Smith Center for Research in Scienti c and control design, we consider a theory for ferroelectric hysteresis which is based on domain wall dynamics been recognized that domain and domain wall mechanisms within ferroelectric materi- als result

245

A Domain Wall Theory for Ferroelectric Hysteresis Ralph C. Smith  

E-print Network

A Domain Wall Theory for Ferroelectric Hysteresis Ralph C. Smith Center for Research in Scientific and control design, we consider a theory for ferroelectric hysteresis which is based on domain wall dynamics been recognized that domain and domain wall mechanisms within ferroelectric materi­ als result

246

Titan's atomic and molecular nitrogen tori H. T. Smith,1  

E-print Network

Titan's atomic and molecular nitrogen tori H. T. Smith,1 R. E. Johnson,1 and V. I. Shematovich2] Shematovich et al. recently showed plasma induced sputtering in Titan's atmosphere is a source of neutral a toroidal nitrogen cloud roughly centered at Titan's orbital radius but gravitationally bound to Saturn

Johnson, Robert E.

247

The Historic Context for Visual Literacy: Walter Smith and Others.  

ERIC Educational Resources Information Center

This paper relates visual literacy to the historical development of art education in the United States, emphasizing the work of Walter Smith, an art educator, during the later nineteenth century. The visual mode of learning, especially drawing, in public schools has been justified as a means to furthering industrialization and as an end in itself,…

Plummer, Gordon S.

248

Michelle Smith: An Irish Language Hero for Celtic Tiger Ireland?  

Microsoft Academic Search

Michelle Smith remains one of the most controversial Irish athletes of the twentieth century. Her victories at the swimming events of the 1996 Atlanta Games made her a hero in the eyes of the Irish nation. By exploring her life and swimming career, this article examines how a national hero was created and the reasons why she was so readily

Brian Ó Conchubhair

2005-01-01

249

The Pharmacodynamics of Antibiotic Treatment Mudassar Imran and Hal Smith  

E-print Network

The Pharmacodynamics of Antibiotic Treatment Mudassar Imran and Hal Smith Department of Mathematics of the effects of periodic, discrete dosing or constant dosing of antibiotics on a bacterial population whose and an infection-state are locally stable when antibiotic dosing is marginal. In this case, treatment success may

Smith, Hal

250

Prof. Michael Melliar-Smith COMPUTER ENGINEERING GROUP  

E-print Network

SYSTEMS Department of Electrical & Computer Engineering ·Human-Computer Interactions: Move from text input of a multimedia human interface ·Computer-Computer Interactions: Move from traditional transaction protocolsProf. Michael Melliar-Smith COMPUTER ENGINEERING GROUP Department of Electrical & Computer

Akhmedov, Azer

251

Wholemovement of the circle Bradford Hansen-Smith  

E-print Network

171 Wholemovement of the circle Bradford Hansen-Smith 4606 N. Elston #3, Chicago IL 60630, USA brad that demonstrates the concept of Wholeness. When compressed to a single plane, the sphere is reformed to a circle into the Wholeness of this energy creation. The circle is a compressed, reformed sphere. Everything we #12;172 know

Spagnolo, Filippo

252

ATM Rate-Based Congestion Control Using a Smith Predictor  

Microsoft Academic Search

This paper presents a feedback control algorithm for ATM congestion control in which ABR source rates are throttled according to VC queue levels at intermediate nodes along the path. The goal is to “fill in” the residual bandwidth, without exceeding a specified queue threshold. In order to obtain this, we propose a simple and classical proportional controller, plus a Smith

Saverio Mascolo; Dirceu Cavendish; Mario Gerla

1997-01-01

253

MIMO Smith predictor: Global and structured robust performance analysis  

Microsoft Academic Search

The purpose of this work is to extend the analysis of the Smith predictor structure to multiple input multiple output (MIMO) systems with uncertain multiple delays. This is applied to the set of models that can be factorized into a rational MIMO model in series with left\\/right diagonal (multiple) delay matrices. Necessary and sufficient conditions on the plant’s model to

Ricardo S. Sánchez-Peña; Yolanda Bolea; Vicenç Puig

2009-01-01

254

Redesign of Smith predictor systems for performance enhancement  

Microsoft Academic Search

In this paper, a new design for Smith Predictor systems is presented. It employs a deliberately mismatched model to enhance performance over a perfectly matched system while using a simple primary controller. The design methodology is formulated in the frequency domain as an optimization problem and it turns out that an approximate solution can be obtained using the linear least

Qing-Guo Wang; Qiang Bi; Yong Zhang

2000-01-01

255

Automatic tuning of the modified Smith predictor controllers  

Microsoft Academic Search

A simple relay feedback automatic tuning method is proposed for the modified Smith predictor, to provide a controller for stable, unstable and integrating processes with long dead time. A single asymmetrical relay feedback test is used to obtain a reduced order process model in terms of a second order dynamics plus dead time model. Very simple but straightforward tuning formulae

S. Majhi; Derek P. Atherton

2000-01-01

256

A new modified Smith predictor: the concept, design and tuning  

Microsoft Academic Search

The paper presents a new modified Smith predictor (MSP) for processes with a long time delay. The MSP appears as an extension of the double controller-scheme (DCS) proposed by Tian and Gao. The important feature of the MSP is that the trade-off between disturbance rejection and robustness to variations in process parameters can be adjusted by means of a single

Darko Vre?ko; Damir Vran?i?; ?ani Juri?i?; Stanko Strm?nik

2001-01-01

257

Automatic Smith-predictor tuning using optimal parameter mismatch  

Microsoft Academic Search

The Smith-predictor is famous for its delay-free characteristic and suitable for regulating systems with an excessively long time delay. However, it is sensitive to plant parameter variations based on some frequency domain studies. In this paper, detailed analyzes of the system performance through parametric and temporal mismatch are investigated and accompanied with closed form solutions. Based on the derived solutions,

Jih-Jenn Huang; Daniel B. DeBra

2002-01-01

258

Analytical design and analysis of mismatched Smith predictor  

Microsoft Academic Search

In this paper, an analytical design method is developed for the mismatched Smith predictor on the basis of the internal model control (IMC) method. Design formulas are given and design procedure is significantly simplified. One important merit of the proposed method is that the response of the closed loop system can be easily adjusted. The relation between the controller parameter

Weidong Zhang; Xiaoming Xu

2001-01-01

259

Smith Mountain--Leesville project: a case history  

Microsoft Academic Search

The Smith Mountain Pump Storage Project consists of two reservoirs in tandem on the Roanoke and Blackwater Rivers approximately 64 km southeast of Roanoke, Virginia. The reservoirs have provided sites for evaluating the impact of pump storage operation on primary productivity, fisheries, and water quality. Due to the location of the dam and the dendritic nature of the basin, the

GEORGE M. SIMMONS; G. M. Jr

1976-01-01

260

2010 MSU Horticulture Gardens Glass Art by Craig Mitchell Smith Photos by Art and Marlene Cameron  

E-print Network

2010 MSU Horticulture Gardens ­ Glass Art by Craig Mitchell Smith Photos by Art and Marlene Cameron #12;2010 MSU Horticulture Gardens ­ Glass Art by Craig Mitchell Smith Photos by Art and Marlene Cameron #12;2010 MSU Horticulture Gardens ­ Glass Art by Craig Mitchell Smith Photos by Art and Marlene

261

Inequality and the Dayton Tax-Budget Plan Jay Coggins and Dane Smith  

E-print Network

Dalio's income: 5.294 miles Jay Coggins and Dane Smith Inequality and the Dayton Tax-Budget Plan #12 and Dane Smith Inequality and the Dayton Tax-Budget Plan #12;% growth in income, bottom quintile, 1979 Coggins and Dane Smith Inequality and the Dayton Tax-Budget Plan #12;% growth in income, bottom 99%, 1979

Weiblen, George D

262

The Library of Maynard-Smith: My Search for Meaning in the Protein  

E-print Network

The Library of Maynard-Smith: My Search for Meaning in the Protein Universe Borges's infinite, and unsearchable, library is reflected in the Maynard-Smith collection of all possible protein sequences Frances H searching for meaning in one of the virtual rooms of the Library of Mendel, the Maynard-Smith Collection

Arnold, Frances H.

263

A unified Smith predictor based on the spectral decomposition of the plant  

Microsoft Academic Search

We point out a numerical problem in the well-known modified Smith predictor and propose a unified Smith predictor (USP) which overcomes this problem. The proposed USP combines the classical Smith predictor with the modified one, after a spectral decomposition of the plant. We then derive an equivalent representation of the original delay system, together with the USP. Based on this

Qing-Chang Zhong; George Weiss

2004-01-01

264

Networked control systems based on generalized predictive control and modified Smith predictor  

Microsoft Academic Search

The distributed control networks encounter nondeterministic delays in data communication between sensors, actuators and controllers, including direct-feedback control and higher level supervisor control. Aiming to uncertain network delays, time-variant or nonlinear controlled plant and imprecise Smith predictor models, a novel approach is proposed that modified Smith predictor combined with generalized predictive control (GPC). Because modified Smith predictor does not include

Du Feng; Qian Qingquan

2008-01-01

265

Modified Smith predictor control for multivariable systems with delays and unmeasurable step disturbances  

Microsoft Academic Search

The paper presents a new disturbance rejection version of the Smith predictor control system (Smith 1959) and of the multivariable one (Donoghue 1977). The method uses a dynamical compensator and can decay the output error to disturbances as fast as desired without any change of the input-output transfer characteristics of the Smith predictor control system. The design procedure of the

KEIJI WATANABE; YASUNORI ISHIYAMA; MASAMI ITO

1983-01-01

266

PLEASE SCROLL DOWN FOR ARTICLE This article was downloaded by: [Smith, Lloyd V.  

E-print Network

PLEASE SCROLL DOWN FOR ARTICLE This article was downloaded by: [Smith, Lloyd V.] On: 21 February and challenges in numerically modelling solid sports balls with application to softballs Lloyd V. Smith, Washington, USA First Published:January2009 To cite this Article Smith, Lloyd V. and Duris, Joseph G.(2009

Smith, Lloyd V.

267

SPECTRAL CLUSTER ESTIMATES FOR C1,1 HART F. SMITH  

E-print Network

SPECTRAL CLUSTER ESTIMATES FOR C1,1 METRICS HART F. SMITH Abstract. In this paper, we establish Lp this limited regularity assumption. It is known by examples of Smith-Sogge [11] that such estimates fail for C1.) In Smith-Sogge [11], for each

Smith, Hart F.

268

Vorticity and Divergence of Surface Velocities Near Shore JEROME A. SMITH  

E-print Network

Vorticity and Divergence of Surface Velocities Near Shore JEROME A. SMITH Scripps Institution, and nearshore mixing-scale motions are generally undersampled (but see, e.g., Smith and Largier 1995; Johnson m 300 m on a side (Smith 2002a,b). Thus, these data focus more toward the small end of the range

Smith, Jerome A.

269

PLEASE SCROLL DOWN FOR ARTICLE This article was downloaded by: [Smith, Bradley  

E-print Network

PLEASE SCROLL DOWN FOR ARTICLE This article was downloaded by: [Smith, Bradley] On: 19 March 2009 of stopper size on squaraine rotaxane stability Na Fu a ; Jeremiah J. Gassensmith a ; Bradley D. Smith: 01 January 2009 To cite this Article Fu, Na, Gassensmith, Jeremiah J. and Smith, Bradley D.(2009

Smith, Bradley D.

270

77 FR 64411 - Safety Zone; Cooper T. Smith Fireworks Event; Mobile River; Mobile, AL  

Federal Register 2010, 2011, 2012, 2013

...USCG-2012-0869] RIN 1625-AA00 Safety Zone; Cooper T. Smith Fireworks Event; Mobile River...vessels on navigable waters during the Cooper T. Smith Fireworks Event. Entry into, transiting...fireworks display. B. Basis and Purpose Cooper T. Smith Corp. has hired Pyro Tecnico...

2012-10-22

271

X-29 Research Pilot Rogers Smith  

NASA Technical Reports Server (NTRS)

Rogers Smith, a NASA research pilot, is seen here at the cockpit of the X-29 forward-swept-wing technology demonstrator at NASA's Ames-Dryden Flight Research Facility (later the Dryden Flight Research Center), Edwards, California, in 1988. The X-29 explored the use of advanced composites in aircraft construction; variable camber wing surfaces; the unique forward-swept-wing and its thin supercritical airfoil; strake flaps; and a computerized fly-by-wire flight control system that overcame the aircraft's instability. Grumman Aircraft Corporation built two X-29s. They were flight tested at Dryden from 1984 to 1992 in a joint NASA, DARPA (Defense Advanced Research Projects Agency) and U.S. Air Force program. Two X-29 aircraft, featuring one of the most unusual designs in aviation history, flew at the Ames-Dryden Flight Research Facility (now the Dryden Flight Research Center, Edwards, California) from 1984 to 1992. The fighter-sized X-29 technology demonstrators explored several concepts and technologies including: the use of advanced composites in aircraft construction; variable-camber wing surfaces; a unique forward- swept wing and its thin supercritical airfoil; strakes; close-coupled canards; and a computerized fly-by-wire flight control system used to maintain control of the otherwise unstable aircraft. Research results showed that the configuration of forward-swept wings, coupled with movable canards, gave pilots excellent control response at angles of attack of up to 45 degrees. During its flight history, the X-29 aircraft flew 422 research missions and a total of 436 missions. Sixty of the research flights were part of the X-29 follow-on 'vortex control' phase. The forward-swept wing of the X-29 resulted in reverse airflow, toward the fuselage rather than away from it, as occurs on the usual aft-swept wing. Consequently, on the forward-swept wing, the ailerons remained unstalled at high angles of attack. This provided better airflow over the ailerons and prevented stalling (loss of lift) at high angles of attack. Introduction of composite materials in the 1970s opened a new field of aircraft construction. It also made possible the construction of the X-29's thin supercritical wing. State-of-the-art composites allowed aeroelastic tailoring which, in turn, allowed the wing some bending but limited twisting and eliminated structural divergence within the flight envelope (i.e. deformation of the wing or the wing breaking off in flight). Additionally, composite materials allowed the wing to be sufficiently rigid for safe flight without adding an unacceptable weight penalty. The X-29 project consisted of two phases plus the follow-on vortex-control phase. Phase 1 demonstrated that the forward sweep of the X-29 wings kept the wing tips unstalled at the moderate angles of attack flown in that phase (a maximum of 21 degrees). Phase I also demonstrated that the aeroelastic tailored wing prevented structural divergence of the wing within the flight envelope, and that the control laws and control-surface effectiveness were adequate to provide artificial stability for an otherwise unstable aircraft. Phase 1 further demonstrated that the X-29 configuration could fly safely and reliably, even in tight turns. During Phase 2 of the project, the X-29, flying at an angle of attack of up to 67 degrees, demonstrated much better control and maneuvering qualities than computational methods and simulation models had predicted . During 120 research flights in this phase, NASA, Air Force, and Grumman project pilots reported the X-29 aircraft had excellent control response to an angle of attack of 45 degrees and still had limited controllability at a 67-degree angle of attack. This controllability at high angles of attack can be attributed to the aircraft's unique forward-swept wing- canard design. The NASA/Air Force-designed high-gain flight control laws also contributed to the good flying qualities. During the Air Force-initiated vortex-control phase, the X-29 successfully demonstrated vortex flow control (VFC). This VFC was more effective t

1988-01-01

272

Defenses and morality: adam smith, sigmund freud, and contemporary psychoanalysis.  

PubMed

In this paper we follow the development and transmission of moral learning from Adam Smith's impartial spectator to Sigmund Freud's superego and then to contemporary psychoanalysis. We argue that defenses are an integral component in the acquisition of any moral system. Elaborating on this argument, we assert that there is a progression from defensive systems that are "closed" to defensive systems that are "open," as defined in a recent work by Novick and Novick. The former system is "static, avoids reality, and is characterized by power dynamics, sadomasochism, and omnipotent defense." The latter, on the other hand, is a system that allows for "joy, creativity, spontaneity, love and it is attuned to reality." Furthermore, while Smith and Freud's systems are more one-person systems of defense, contemporary psychoanalysis has moved to more of a two-person system. PMID:25247288

Gabrinetti, Paul A; Ozler, Sule

2014-10-01

273

Fenimore Art Museum: The Smith and Telfer Photographic Collection  

NSDL National Science Digital Library

The Fenimore Art Museum in New York has a wide-ranging collection that includes significant pieces of American Indian art, folk art, and thousands of photographs and negatives. Working together with other institutions, including the New York State Historical Association, they have digitized over 300 images from the Smith and Telfer Photographic Collection. The firm of Smith and Telfer documented the town of Cooperstown, NY for well over a century, and they took photos of circus animals, civic monuments, and prominent individuals. Visitors can browse through the images at their leisure, and they can also search the entire collection by keyword. A couple of images of note include the shot of a man holding a dog in his lap while sitting on a tractor ("Ainslie Cornfield") and the photo entitled "Balloon Ascension".

274

Constitutive relations associated with the Mott-Smith distribution function  

USGS Publications Warehouse

It is shown that the distribution function assumed by Mott-Smith determines a unique relation between heat flux, stress, and fluid velocity given by q = (3/2)??u, i.e., it provides a constitutive relation for heat flux, and it also determines a simple expression for this ratio of third-order central moments Q = . These expressions allow the equation of transfer for c x2 to be cast in a form that yields a nonlinear constitutive relation for stress. The results obtained from the Mott-Smith ansatz are compared with the theory of Baganoff and Nathenson and results from a numerical solution of the Boltzmann equation for shock-wave structure obtained by Hicks and Yen.

Nathenson, M.; Baganoff, D.

1973-01-01

275

The rhetoric of economic inquiry in Smith, Whately, and Mill  

E-print Network

character advocated so eloquently by McCloskey to the Homeric and Christian virtues. I also compare the present bourgeois society based on the work of Adam Smith with another liberal view of society as advocated by Jean-Jacques Rousseau. The comparisons... reveal that the present constitution of bourgeois society and its social world is unlike a Christian society, and that a view of citizenship akin to Rousseau?s would help us to constitute persons holistically, rather than as separate selves...

Gore, David Charles

2005-08-29

276

Paternity and paternal care in the polygynandrous Smith's longspur  

Microsoft Academic Search

In species where females copulate with more than one male during a single breeding attempt, males risk investing in offspring\\u000a that are not their own. In the polygynandrous Smith's longspur (Calcarius pictus), females copulate sequentially with one to three males for each clutch of eggs and most of these males later assist in feeding\\u000a the young. Using multilocus DNA profiling,

James V. Briskie; Robert Montgomerie; Tarmo Põldmaa; Peter T. Boag

1998-01-01

277

Visual servoing with modified Smith predictor for micromanipulation tasks  

Microsoft Academic Search

A control scheme with a modified Smith predicator (MSP) for the position-based dynamic look-and-move visual servoing for the control of micromanipulation is proposed. Due to the time consuming image acquisition, transfer, and processing, the visual servoing has an inherent time delay, which seriously damage the system performance. Previously, the most common method is to decrease the primary gains to increase

Hui Xie; Lining Sun; Weibin Rong; Xiufeng Yuan

2005-01-01

278

Improving performance using cascade control and a Smith predictor  

Microsoft Academic Search

Many investigations have been done on tuning proportional-integral-derivative (PID) controllers in single-input single-output (SISO) systems. However, only a few investigations have been carried out on tuning PID controllers in cascade control systems. In this paper, a new approach, namely the use of a Smith predictor in the outer loop of a cascade control system, is investigated. The method can be

Ibrahim Kaya

2001-01-01

279

Obtaining controller parameters for a new Smith predictor using autotuning  

Microsoft Academic Search

The paper extends recent work on a modified Smith predictor strategy, which leads to significant improvements in its regulatory capacities for reference inputs and disturbances. High-order or long dead time stable, integrating and unstable plants are modelled as lower-order plant models with a longer time delay. The controllers are designed so that the delay-free component of the output is tuned

Somanath Majhi; Derek P. Atherton

2000-01-01

280

Test of Cairns-Smith's 'crystals-as-genes' hypothesis.  

PubMed

One aspect of the multifaceted proposal by A. G. Cairns-Smith, that imperfect crystals have the capacity to act as primitive genes by transferring the disposition of their imperfections from one crystal to another, is investigated. Rather than examining clay minerals, the most likely crystalline genes in the theories of Cairns-Smith, an experiment was designed in a model crystalline system unrelated to the composition of the prebiotic earth but suited to a well-defined test. Plates of potassium hydrogen phthalate riddled with dislocations were studied in order to ascertain whether, according to Cairns-Smith, parallel screw dislocations could serve as an information store with cores akin to punches in an old computer card. Evidence of screw dislocations was obtained from their associated growth hillocks through differential interference contrast microscopy, atomic force microscopy, and luminescence labeling of hillocks in conjunction with confocal laser scanning microscopy. The dispositions of growth active hillocks were quantified by fractal analysis. 'Mother' crystals were cleaved and inheritance was evaluated by the corresponding patterns of luminescence developed in their 'daughters' after continued growth in the presence of fluorophores. Luminescence microscopy proves to be a versatile tool for studying the dynamics of growth active hillocks. In the aggregate, this work speaks to the need for molecular mechanisms of dislocation nucleation. PMID:17955812

Bullard, Theresa; Freudenthal, John; Avagyan, Serine; Kahr, Bart

2007-01-01

281

An extension of the Smith Predictor method to multivariable linear systems containing time delays  

Microsoft Academic Search

The classical Smith Predictor method for single variable systems is extended to a class of linear multivariable systems. Derivations of the multivariable Smith Predictor are presented for both continuous-time and discrete-time systems which contain time delays in the control variables and\\/or output variables. As in the classical method, use of the multivariable Smith Predictor eliminates the time delays from the

G. ALEVISAKIS; D. E. SEBORG

1973-01-01

282

Modified Smith Predictor and Controller for Time-Delay Process with Uncertainty  

Microsoft Academic Search

Smith predictor is very sensitive to uncertain system with variable time-delay. Using dual-locus diagram method, we first analyse the essence of Smith predictor's sensitivity and present a proposition to illustrate the system stability criteria with relation to system gain and time-delay variation. Then a new modified Smith predictor is proposed to compensate the variable time-delay system with uncertain model for

Shihua Wang; Bugong Xu; Qingyang Wang; Yun-Hui Liu

2006-01-01

283

Gilbert M. Smith, master boatbuilder of Long Island, New York  

E-print Network

GILBERT M. SMITH, MASTER BOATBUILDER OF LONG ISLAND, NEW YORK A Thesis by DARIA ELIZABETH MERWIN Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree of MASTER OF ARTS... May 2000 Major Subject: Anthropology OF LONG ISLAND, NEW YORK A Thesis by DARIA ELIZABETH MERWIN Submitted to the Office of Graduate Studies of Texas A8UVI University in partial fulfillment of the requirements for the degree of MASTER OF ARTS...

Merwin, Daria Elizabeth

2012-06-07

284

Medicine in old Fort Smith: struggles with mud and quacks.  

PubMed

Dr. J. G. Eberle's efforts to pave the streets of Fort Smith are illustrative of the challenges facing Arkansas in the nineteenth century. Development of sewers, drains, and a safe water supply helped control epidemics of malaria, yellow fever, cholera, and other forms of dysentery. During this time the medical profession struggled to establish professional standards before the great reforms of medical education took hold in the twentieth century. The military hospital of the Civil War was a precursor of the role hospitals would play in bringing higher standards of care to their communities. PMID:24494351

Prewitt, Taylor

2013-12-01

285

A Search For Star Formation in the Smith Cloud  

E-print Network

Motivated by the idea that a subset of HVCs trace dark matter substructure in the Local Group, we search for signs of star formation in the Smith Cloud, a nearby ~2x10^6 Msun HVC currently falling into the Milky Way. Using GALEX NUV and WISE/2MASS NIR photometry, we apply a series of color and apparent magnitude cuts to isolate candidate O and B stars that are plausibly associated with the Smith Cloud. We find an excess of stars along the line of sight to the cloud, but not at a statistically significant level relative to a control region. The number of stars found in projection on the cloud after removing an estimate of the contamination by the Milky Way implies an average star formation rate surface density of 10^(-4.8 +/- 0.3) Msun yr^(-1) kpc^(-2), assuming the cloud has been forming stars at a constant rate since its first passage through the Milky Way ~70 Myr ago. This value is consistent with the star formation rate expected based on the average gas density of the cloud. We also discuss how the newly d...

Stark, David V; Kannappan, Sheila J

2014-01-01

286

The futility of utility: how market dynamics marginalize Adam Smith  

NASA Astrophysics Data System (ADS)

Economic theorizing is based on the postulated, nonempiric notion of utility. Economists assume that prices, dynamics, and market equilibria are supposed to be derived from utility. The results are supposed to represent mathematically the stabilizing action of Adam Smith's invisible hand. In deterministic excess demand dynamics I show the following. A utility function generally does not exist mathematically due to nonintegrable dynamics when production/investment are accounted for, resolving Mirowski's thesis. Price as a function of demand does not exist mathematically either. All equilibria are unstable. I then explain how deterministic chaos can be distinguished from random noise at short times. In the generalization to liquid markets and finance theory described by stochastic excess demand dynamics, I also show the following. Market price distributions cannot be rescaled to describe price movements as ‘equilibrium’ fluctuations about a systematic drift in price. Utility maximization does not describe equilibrium. Maximization of the Gibbs entropy of the observed price distribution of an asset would describe equilibrium, if equilibrium could be achieved, but equilibrium does not describe real, liquid markets (stocks, bonds, foreign exchange). There are three inconsistent definitions of equilibrium used in economics and finance, only one of which is correct. Prices in unregulated free markets are unstable against both noise and rising or falling expectations: Adam Smith's stabilizing invisible hand does not exist, either in mathematical models of liquid market data, or in real market data.

McCauley, Joseph L.

2000-10-01

287

‘A Glance from God’: Zadie Smith's On Beauty and Zora Neale Hurston1  

Microsoft Academic Search

Zadie Smith's most recent novel, On Beauty (2005), declares its connection to E. M. Forster's Howards End (1910) with its first line, while the novel's title comes from Elaine Scarry's On Beauty and Being Just (1999). At least as important for understanding Smith's central vision are the novel's allusions to Zora Neale Hurston's Their Eyes Were Watching God (1937) and

Susan Alice Fischer

2007-01-01

288

VIEW OF H.M. CAMP SMITH RECREATIONAL AREA, WITH MANANA HOUSING ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

VIEW OF H.M. CAMP SMITH RECREATIONAL AREA, WITH MANANA HOUSING AREA IN THE FAR LEFT DISTANCE. VIEW FACING EAST - Camp H.M. Smith and Navy Public Works Center Manana Title VII (Capehart) Housing, Intersection of Acacia Road and Brich Circle, Pearl City, Honolulu County, HI

289

The Behavioural Phenotype of Smith-Magenis Syndrome: Evidence for a Gene-Environment Interaction  

ERIC Educational Resources Information Center

Background: Behaviour problems and a preference for adult contact are reported to be prominent in the phenotype of Smith-Magenis syndrome. In this study we examined the relationship between social interactions and self-injurious and aggressive/disruptive behaviour in Smith-Magenis syndrome to explore potential operant reinforcement of problem…

Taylor, L.; Oliver, C.

2008-01-01

290

Speech/Language Pathologists Reflect on Sally Smith and the Lab School of Washington  

ERIC Educational Resources Information Center

Sally L. Smith had a clear vision of how she thought speech and language services should be integrated into her school, The Lab School of Washington. It was Smith's idea that language therapists should work individually with students to help them make gains in their particular areas of need, as well as to work collaboratively with the teachers,…

Learning Disabilities: A Multidisciplinary Journal, 2010

2010-01-01

291

Dyadic Power Theory, Touch, and Counseling Psychology: A Response to Smith, Vogel, Madon, and Edwards (2011)  

ERIC Educational Resources Information Center

Smith, Vogel, Madon, and Edwards' (2011) recent article tested dyadic power theory (DPT) by examining the use of touch as a compliance-gaining tactic in the conflicts of married couples. In this response, we raise a methodological issue about the touch behaviors examined by Smith et al. and also pose a theoretical critique that their test of DPT…

Dunbar, Norah E.; Abra, Gordon

2012-01-01

292

Unconscious Odour Conditioning 25 Years Later: Revisiting and Extending "Kirk-Smith, Van Toller and Dodd"  

ERIC Educational Resources Information Center

The pioneering work by Kirk-Smith, Van Toller, and Dodd [Kirk-Smith, M. D., Van Toller, C., & Dodd, G. H. (1983). "Unconscious odour conditioning in human subjects." "Biological Psychology," 17, 221-231], established that an unnoticed odorant paired with an emotionally meaningful task can influence mood and attitudes when the odorant alone is…

Zucco, Gesualdo M.; Paolini, Michela; Schaal, Benoist

2009-01-01

293

An Alternative View of the Instructional Design Process: A Response to Smith and Boling  

ERIC Educational Resources Information Center

A recent literature review by Smith and Boling (2009) critically examines the received view of instructional design in educational technology. Smith and Boling conclude that the foundational literature characterizes design in a way that leads to a constrained understanding of design, especially by novices. They suggest that as a field we move…

Gibbons, Andrew S.; Yanchar, Stephen C.

2010-01-01

294

Two Rival Conceptions of Vocational Education: Adam Smith and Friedrich List.  

ERIC Educational Resources Information Center

Examines and discusses two views of political economy: (1) the classical model of Adam Smith; and (2) the social capitalist model associated with Friedrich List. Explores two varieties of vocational education and training that emerge from a comparison of Smith's and List's ideas. (CMK)

Winch, Christopher

1998-01-01

295

Networks, Buffer Allocation Problem typeset May 18, 2004 Smith & Cruz The Buffer Allocation Problem for  

E-print Network

Networks, Buffer Allocation Problem typeset May 18, 2004 Smith & Cruz The Buffer Allocation Problem for General Finite Buffer Queueing Networks J. MacGregor Smith F. R. B. Cruz e-mail: jmsmith@ecs.umass.edu e-mail: fcruz@ufmg.br May 18, 2004 Abstract -- The Buffer Allocation Problem (BAP) is a difficult stochastic

Cruz, Frederico

296

PREDATION BY THE GRAPSID CRAB, ARMASES ANGUSTUM (SMITH, 1870), ON TADPOLES OF THE GREEN POISON FROG,  

E-print Network

PREDATION BY THE GRAPSID CRAB, ARMASES ANGUSTUM (SMITH, 1870), ON TADPOLES OF THE GREEN POISON FROG crab, Armases angustum (Smith, 1870), was found in one of the treeholes of a buttress tree that was used heavily by Dendrobates auratus Girard, 1855 for breeding. The crab ate tadpoles in captivity

Bermingham, Eldredge

297

THE HAPPY MARRIAGE: THE INFLUENCE OF CHARLOTTE SMITH ON JANE AUSTEN  

Microsoft Academic Search

All of Jane Austen's fiction shows the repeated influence of Charlotte Smith's nine novels. In the Juvenilia Jane Austen openly exploited Charlotte Smith's Emmeline and Ethelinde more closely than she was ever to use any other novels, referring to them as the prototype of popular current literature. Although Frank W. Bradbrook has noted a few verbal echoes of Emmeline and

WILLIAM H. MAGEE

1975-01-01

298

Sagenodus (Proceratodus) carlinvillensis (Romer and Smith 1934), (Osteichthyes: Dipnoi), short ridge anomaly and classification of dipnoans  

Microsoft Academic Search

A genus and species of dipnoan, originally described as Proceratodus carlinvillensis by Romer and Smith (1934), from Pennsylvanian deposits in Illinois, is assigned to the genus Sagenodus. It is identical in characters reliable at the generic level to the type species of Sagenodus, and differs significantly from species of the related genera Ctenodus and Tranodis. Romer and Smith's specimen is

A. Kemp

1996-01-01

299

THE CLASS 0 OUTFLOW HAMMERED OUT? MICHAEL D. SMITH, ROLAND V  

E-print Network

THE CLASS 0 OUTFLOW HAMMERED OUT? MICHAEL D. SMITH, ROLAND V ¨ OLKER , GERHARD SUTTNER AND HAROLD W developed and applied by Suttner et al. (1997) and Smith et al. (1997a). Its successes and failures dissociation and reformation. We found that three­dimensional models are necessary although one­ and two­ #12

Völker, Roland

300

PERTURBATIONS OF THE COUPLED JEFFERY-STOKES STEPHEN MONTGOMERY-SMITH  

E-print Network

PERTURBATIONS OF THE COUPLED JEFFERY-STOKES EQUATIONS STEPHEN MONTGOMERY-SMITH Abstract. This paper with the assumption that Jeffery's equation (Jeffery, 1923), or some variation of it, is a good predictor is assumed to arise from the fibers colliding with each 1 #12;2 STEPHEN MONTGOMERY-SMITH Low viscosity Low

Montgomery-Smith, Stephen

301

Set point weighted modified Smith predictor for integrating and double integrating processes with time delay  

Microsoft Academic Search

A simple method of designing the controllers for a modified form of Smith predictor is proposed for integrating and double integrating processes with time delay. The modified Smith predictor has two controllers, namely, a set point tracking controller and a load disturbance rejection controller for obtaining good set point tracking and load disturbance rejection, respectively. The set point tracking controller

A. Seshagiri Rao; V. S. R. Rao; M. Chidambaram

2007-01-01

302

Smith predictor based-sliding mode controller for integrating processes with elevated deadtime  

Microsoft Academic Search

An approach to control integrating processes with elevated deadtime using a Smith predictor sliding mode controller is presented. A PID sliding surface and an integrating first-order plus deadtime model have been used to synthesize the controller. Since the performance of existing controllers with a Smith predictor decrease in the presence of modeling errors, this paper presents a simple approach to

Oscar Camacho; Francisco De la Cruz

2004-01-01

303

A simple adaptive Smith-predictor for controlling time-delay systems: A tutorial  

Microsoft Academic Search

This heuristic paper presents several simple techniques for analyzing the stability of time-delay systems. It explains the Smith predictor control scheme for time-delay systems and shows how errors in modeling the plant parameters can cause instability. Then an adaptive controller is added to the Smith predictor system; this pedagogical example offers a complete derivation of a simple adaptive control system.

A. Terry Bahill

1983-01-01

304

Robust PID tuning for Smith predictor in the presence of model uncertainty  

Microsoft Academic Search

This paper presents robust PID tuning for the Smith predictor in the presence of model uncertainty. The concept of the equivalent gain plus time delay (EGPTD) is introduced to incorporate robust stability in PID tuning of the Smith predictor. In particular, an application is developed for the robust tuning of the first order plus time delay (FOPTD) system and the

Dongkwon Lee; Moonyong Lee; Suwhan Sung; Inbeum Lee

1999-01-01

305

Active Queue Management Controller using Smith Predictor for Time Delay Networks  

Microsoft Academic Search

This paper presents an investigation into a robust controller for active queue management (AQM) using Smith predictor (SP). A new SP random early detector (RED) controller is proposed and compared with traditional RED based controller. It is worth noting that the RED controller is augmented by a Smith predictor structure for plants with medium and high time delays. The proposed

Rafe Khalaf Alasem; M. Alamgir Hossain; Irfan-ullah Awan

2007-01-01

306

Quantitative Performance Design of a Modified Smith Predictor for Unstable Processes with Time Delay  

Microsoft Academic Search

The existence of both right-half-plane poles and time delay makes it difficult to obtain a higher control quality. Recently, a modified Smith predictor for unstable processes with time delay was presented and good performance was obtained. In this paper, the modified Smith predictor is discussed. A modified structure is presented. The new one not only is simple for analysis and

Weidong Zhang; Danying Gu; Wei Wang; Xiaoming Xu

2004-01-01

307

Fuzzy RBF neural network control for networked control systems based on modified Smith predictor  

Microsoft Academic Search

Network delay highly degrades the control performance of networked control systems (NCS). Aiming to random and uncertain network delay, time-variant or nonlinear controlled plant and imprecise Smith predictor models, a novel approach is proposed that modified Smith predictor combined with fuzzy radial basis function neural network (FRBFNN). This approach can identify the controlled plant on-line, timely adjusts the weights of

Du Feng; Qian Qingquan

2008-01-01

308

MICRO SYNTHETIC APERTURE RADAR USING FM/CW Ryan L. Smith  

E-print Network

MICRO SYNTHETIC APERTURE RADAR USING FM/CW TECHNOLOGY by Ryan L. Smith A thesis submitted;ABSTRACT MICRO SYNTHETIC APERTURE RADAR USING FM/CW TECHNOLOGY Ryan L. Smith Department of Electrical of gener- ating high quality images using frequency modulated, continuous wave (FM/CW) technology and it

Long, David G.

309

Stephen F. Smith, Mark S. Fox and Peng Si Ow Constructing and Maintaining Detailed  

E-print Network

Stephen F. Smith, Mark S. Fox and Peng Si Ow Constructing and Maintaining Detailed Production PlansThe Robotics Institute, Carnegie- Mellon University, Pittsburgh, Pennsylvania 15213 Mark S. Fox is the director (Fox, Allen, and Strohm 1982; Fox 1983; Fox and Smith 1984a, 1984b). ISIS-2 was demon- strated

Fox, Mark S.

310

78 FR 6173 - Diana Del Grosso, Ray Smith, Joseph Hatch, Cheryl Hatch, Kathleen Kelley, Andrew Wilklund, and...  

Federal Register 2010, 2011, 2012, 2013

...35652] Diana Del Grosso, Ray Smith, Joseph Hatch, Cheryl Hatch, Kathleen Kelley...2012, by Diana Del Grosso, Ray Smith, Joseph Hatch, Cheryl Hatch, Kathleen Kelley...23, 2013. By the Board, Rachel D. Campbell, Director, Office of Proceedings....

2013-01-29

311

* Camera connections in Comm. Ctr and all digital equipment *Officers Currently in the FTO Program : Cody Smith  

E-print Network

: Cody Smith UPD Staff as of 9.5.13 Associate Director University Police Major Levelle 63 Assistant Graves 22 Officer Currie 68 Officer Smith 15 Officer Olivo Officer Mills Divisional Campuses Assistant

Mohaghegh, Shahab

312

THE USE OF RADIAL VELOCITY DERIVATIVE TO DIAGNOSE ROTATION AND DIVERGENCE Travis M. Smith1,2, *  

E-print Network

P5.6 THE USE OF RADIAL VELOCITY DERIVATIVE TO DIAGNOSE ROTATION AND DIVERGENCE Travis M. Smith1 was implemented in NSSL's Damaging Downburst Prediction and Detection Algorithm (Smith et al. 2004) for detecting

Smith, Travis

313

Circadian rhythm abnormalities of melatonin in Smith-Magenis syndrome  

PubMed Central

BACKGROUND—Smith-Magenis syndrome (SMS) is a multiple congenital anomalies/mental retardation syndrome associated with a hemizygous deletion of chromosome 17, band p11.2. Characteristic features include neurobehavioural abnormalities such as aggressive and self-injurious behaviour and significant sleep disturbances. The majority of patients have a common deletion characterised at the molecular level. Physical mapping studies indicate that all patients with the common deletion are haploinsufficient for subunit 3 of the COP9 signalosome (COPS3), which is conserved from plants to humans, and in the plant Arabidopis thaliana regulates gene transcription in response to light. Haploinsufficiency of this gene is hypothesised to be potentially involved in the sleep disturbances seen in these patients. Melatonin is a hormone secreted by the pineal gland. SMS patients are reported to have fewer sleep disturbances when given a night time dose of this sleep inducing hormone.?METHODS—Urinary excretion of 6-sulphatoxymelatonin (aMT6s), the major hepatic metabolite of melatonin, in 19 SMS patients were measured in conjunction with 24 hour sleep studies in 28 SMS patients. Five of the 28 patients did not have the common SMS deletion. To investigate a potential correlation of COPS3 haploinsufficiency and disturbed melatonin excretion, we performed fluorescence in situ hybridisation (FISH) using two BACs containing coding exons of COPS3.?RESULTS—All SMS patients show significant sleep disturbances when assessed by objective criteria. Abnormalities in the circadian rhythm of aMT6s were observed in all but one SMS patient. Interestingly this patient did not have the common deletion. All patients studied, including the one patient with a normal melatonin rhythm, were haploinsufficient for COPS3.?CONCLUSIONS—Our data indicate a disturbed circadian rhythm in melatonin and document the disturbed sleep pattern in Smith-Magenis syndrome. Our findings suggest that the abnormalities in the circadian rhythm of melatonin and altered sleep patterns could be secondary to aberrations in the production, secretion, distribution, or metabolism of melatonin; however, a direct role for COPS3 could not be established.???Keywords: melatonin; circadian rhythms; Smith-Magenis syndrome; COPS3 PMID:10851253

Potocki, L.; Glaze, D.; Tan, D.; Park, S.; Kashork, C.; Shaffer, L.; Reiter, R.; Lupski, J.

2000-01-01

314

The Adventures of Captain John Smith, Pocahontas and a Sundial: Cosmology, Mathematics, and Power at the Time of Jamestown  

Microsoft Academic Search

While exploring the Chickahominy River in Virginia by canoe in December 1607, Captain John Smith was ambushed by 200 Powhatan Indians and chased into the swamp. Wounded by arrows and mired in the cold mud, Smith surrendered and was led to their chieftain, Opechancanough. Smith played for time. He pulled out his pocket sundial and proceeded to deliver a lecture

Sara J. Schechner

2007-01-01

315

Journal of Motor Behavior, 1993, Vol 25, No.3, 203-216 Is the Cerebellum a Smith Predictor?  

E-print Network

Journal of Motor Behavior, 1993, Vol 25, No.3, 203-216 Is the Cerebellum a Smith Predictor? R that the cerebellum may hold at least two separate Smith Predictors. One, in the lateral cerebellum, would predict cerebellum, would predict the consequences in motor coordinates. Generalization of the Smith Predictor theory

Miall, Chris

316

Influence of harvest, climate and wolf predation on Yellowstone elk, John A. Vucetich, Douglas W. Smith and Daniel R. Stahler  

E-print Network

, Douglas W. Smith and Daniel R. Stahler Vucetich, J. A., Smith, D. W. and Stahler, D. R. 2005. Influence, harvest rate, annual snowfall, and annual precipitation as predictor variables. The best performing models (javuceti@mtu.edu). Á/ D. W. Smith and D. R. Stahler, National Park Service, Yellowstone Center

317

Discovery and early development of squaraine rotaxanes Jeremiah J. Gassensmith, Jeffrey M. Baumes and Bradley D. Smith*  

E-print Network

and Bradley D. Smith* Received (in Cambridge, UK) 5th June 2009, Accepted 17th July 2009 First published macrocycle.7 A few months later a new postdoctoral associate, Dr Easwaran Arunkumar, started in the Smith, 46556, USA. E-mail: smith.115@nd.edu; Fax: +1 5746316652; Tel: +1 5746318632 Jeremiah J. Gassensmith

Smith, Bradley D.

318

Sophia Smith Collection: Population and Reproductive Health Oral History Project  

NSDL National Science Digital Library

Funded by the William and Flora Hewlett Foundation, the Population and Reproductive Health Oral History Project includes accounts of individuals throughout the world who have made valued contributions to the field. The materials here are part of the Women's History Archives at Smith College and the series includes the voices and perspectives of advocates, communication specialists, lawyers, managers, physicians, researchers, and social workers from the period 1965 to 2005. First-time visitors should read the Project History essay and then take a closer look at the several dozen interviews offered here. Those profiled here include the "mother of Asian demography," Mercedes Concepcion, and Lee Minto, the president of Planned Parenthood of Seattle-King County from 1967 to 1993. Other people interviewed here include Daniel E. Pellegrom, Nafis Sadik, and Sara Seims. It's a wonderful archive for persons interested in public health, women's studies, and a range of other crucial areas of academic study.

2013-05-16

319

Special Smith-Purcell radiation from an open resonator array  

NASA Astrophysics Data System (ADS)

An interesting new physical phenomenon is uncovered—an open resonator array excited by an electron beam and able to generate a special kind of Smith-Purcell radiation (SPR). Although the frequency and direction satisfy the SPR relation, this is a single frequency radiation in a specific direction that is essentially different from ordinary SPR. The spectral density of this special radiation is also much higher than that of ordinary SPR. By means of theoretical analysis and digital simulations, the radiation mechanism together with its requirements are explored. This radiation may have great influence in modern physics and optics as it offers new ways to carry out coherent radiation generation and beam diagnostics.

Liu, Weihao; Xu, Zhengyuan

2014-07-01

320

The analysis of convolutional codes via the extended Smith algorithm  

NASA Technical Reports Server (NTRS)

Convolutional codes have been the central part of most error-control systems in deep-space communication for many years. Almost all such applications, however, have used the restricted class of (n,1), also known as 'rate 1/n,' convolutional codes. The more general class of (n,k) convolutional codes contains many potentially useful codes, but their algebraic theory is difficult and has proved to be a stumbling block in the evolution of convolutional coding systems. In this article, the situation is improved by describing a set of practical algorithms for computing certain basic things about a convolutional code (among them the degree, the Forney indices, a minimal generator matrix, and a parity-check matrix), which are usually needed before a system using the code can be built. The approach is based on the classic Forney theory for convolutional codes, together with the extended Smith algorithm for polynomial matrices, which is introduced in this article.

Mceliece, R. J.; Onyszchuk, I.

1993-01-01

321

Periventricular nodular heterotopia in Smith-Magenis syndrome.  

PubMed

Smith-Magenis syndrome (SMS) is caused by an interstitial microdeletion of chromosome 17p11.2. A few patients with the typical SMS phenotype have RAI1 gene mutations. The syndrome is characterized by minor craniofacial anomalies, short stature, sleep disturbances, behavioural and neurocognitive abnormalities, as well as variable multisystemic manifestations. Periventricular nodular heterotopia (PNH) is a genetically heterogeneous neuronal migration disorder characterized by subependymal heterotopic nodules, and is variably associated with other brain malformations, epileptic seizures and intellectual disability. Here we report on two patients harboring deletions of the 17p11.2 region in whom the SMS typical phenotype was associated with bilateral PNH. Our observations expand the spectrum of chromosomal rearrangements associated with PNH and indicate that abnormal neuronal migration may contribute to the neurocognitive phenotype of SMS. © 2014 Wiley Periodicals, Inc. PMID:25257626

Capra, Valeria; Biancheri, Roberta; Morana, Giovanni; Striano, Pasquale; Novara, Francesca; Ferrero, Giovanni Battista; Boeri, Luca; Celle, Maria Elena; Mancardi, Maria Margherita; Zuffardi, Orsetta; Parrini, Elena; Guerrini, Renzo

2014-12-01

322

Smith college secondary math and science outreach program  

SciTech Connect

The Smith College Secondary Math and Science Outreach Program works collaboratively with front-line educators to encourage young women students of all abilities, especially underrepresented and underserved minorities, to continue studying math and science throughout high school. The program includes three main components: (1) Twenty-five to thirty teams of math/science teachers and guidance counselors participate in a year-long program which begins with a three-day Current Students/Future Scientists and Engineering Workshop. This event includes a keynote address, presentations and workshops by successful women in science and engineering, and hands-on laboratory sessions. Each participant receives a stipend and free room and board. Returning to their schools, the teacher-counselor teams implement ongoing plans designed to counteract gender bias in the sciences and to alert female students to the broad range of math, science, and engineering career choices open to them. A follow-up session in the spring allows the teams to present and discuss their year-long activities. (2) TRI-ON, a day of science for 120 ninth- and tenth- grade girls from schools with a large underserved and underrepresented population, is held in early spring. Girls discover the excitement of laboratory investigation and interact with female college science and math majors. (3) Teaching Internships, initiated in 1991, involve ten to fifteen Smith College math and science majors in teaching in public schools. The teaching interns experience the rewards and challenges of classroom teaching, and they also serve as role models for younger students.

Powell, J.A.; Clark, C. [Smith College, Northhampton, MA (United States)

1994-12-31

323

The eleventh reported case of Mulvihill-Smith syndrome in the literature  

PubMed Central

Background The Mulvihill-Smith Syndrome was first recognized in 1975. After the recognition of the Mulvihill-Smith Syndrome, ten cases have been described. Case presentation This article describes the eleventh case of this syndrome in a male patient, 24 years-old with short stature and microcephaly with mild cognitive impairment, deafness and allergic conjunctivitis. The patient was hospitalized several times for repeated infections, and the presence of multiple melanocytic nevi on his skin was noticed. Conclusions Based on the entire set of signs and symptoms presented in our study, it was diagnosed the patient with Mulvihill-Smith Syndrome. PMID:24397283

2014-01-01

324

Fort Smith, mother post of the southwest quartermaster supply and archeological patterning  

E-print Network

r oughly north to south among which was Fort Smith &Fig. 2) . Sut with territorial expansion, and the discovery of gold in California& western trai ls pierced this "Permanent Frontier" causing it to vanish by 1850 &Ferris 1971&3-8) . Maintenance... of Fort Smith began to think of their city as "the principle place of rendezvous every spr ing" for western bound people &Fort Smith Herald, Aug 23& 1848) . In 1849& Captain Randolph B. Marcy with the assistance of Lieutenant John Buford from Fort...

Bento, Sylvia Deborah

2012-06-07

325

Camp H.M. Smith and Navy Public Works Center Manana Title ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Camp H.M. Smith and Navy Public Works Center Manana Title VII (Capehart) Housing, Three-Bedroom Single-Family Type 9, Birch Circle, Elm Drive, Elm Circle, and Date Drive, Pearl City, Honolulu County, HI

326

Fire-scar formation and compartmentalization in Kevin T. Smith and Elaine Kennedy Sutherland  

E-print Network

Fire-scar formation and compartmentalization in oak Kevin T. Smith and Elaine Kennedy Sutherland in April 1995 and 1997 scarred Quercus prinus L. and Q. velutina Lam. Low-intensity fires scorched bark

327

ABUSE: PKI for Real-World Email Trust Chris Masone, Sean Smith  

E-print Network

ABUSE: PKI for Real-World Email Trust Chris Masone, Sean Smith Dartmouth College, Hanover NH 03755; primarily, crisis management in the North American power grid. We have examined tran- scripts of telephone

Smith, Sean W.

328

THE MISSING LUMINOUS BLUE VARIABLES AND THE BISTABILITY Nathan Smith 1  

E-print Network

THE MISSING LUMINOUS BLUE VARIABLES AND THE BISTABILITY JUMP Nathan Smith 1 Center for Astrophysics and Space Astronomy, University of Colorado, 389 UCB, Boulder, CO 80309; nathans@casa.colorado.edu Jorick S

Vink, Jorick

329

77 FR 58181 - Power Resources, Inc., Smith Ranch Highland Uranium Project; License Renewal Request, Opportunity...  

Federal Register 2010, 2011, 2012, 2013

...NRC-2012-0214] Power Resources, Inc., Smith Ranch Highland...Regulatory Commission, Washington, DC 20555-0001...February 1, 2012, Power Resources Inc. (PRI) submitted...Regulatory Commission, Washington, DC...

2012-09-19

330

The Bark Bilinear Transform Julius O. Smith, III Jonathan S. Abel  

E-print Network

The Bark Bilinear Transform Julius O. Smith, III Jonathan S. Abel CCRMA Abel Innovations Stanford and therefore better resolved by a low­order predictor. However, higher order LPC fits could actually be made

Smith III, Julius Orion

331

George E. KidderSmith, April 1945, Photograph #1338. VIEW OF BUILDING ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

George E. Kidder-Smith, April 1945, Photograph #133-8. VIEW OF BUILDING 23, FRONT SIDE FROM ACROSS COURTYARD, FACING WEST - Roosevelt Base, Auditorium-Gymnasium, West Virginia Street between Richardson & Reeves Avenues, Long Beach, Los Angeles County, CA

332

George E. KidderSmith, photographer, April 1945, Photograph #1101. VIEW OF ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

George E. Kidder-Smith, photographer, April 1945, Photograph #110-1. VIEW OF BUILDING 23, SOUTH SIDE WITH ARCADE, FACING NORTHWEST - Roosevelt Base, Auditorium-Gymnasium, West Virginia Street between Richardson & Reeves Avenues, Long Beach, Los Angeles County, CA

333

Adam Smith's rhetorical sympathy: a return of moral sentiments to public policy  

E-print Network

Since Adam Smith's highly successful Wealth of Nations, most scholarship built on his work has been economic in scope and has ignored the greater implications of his contribution to policy-making. This thesis examines the role moral sentiment...

Gore, David Charles

2012-06-07

334

An optimal control approach to pilot/vehicle analysis and Neal-Smith criteria  

NASA Technical Reports Server (NTRS)

The approach of Neal and Smith was merged with the advances in pilot modeling by means of optimal control techniques. While confirming the findings of Neal and Smith, a methodology that explicitly includes the pilot's objective in attitude tracking was developed. More importantly, the method yields the required system bandwidth along with a better pilot model directly applicable to closed-loop analysis of systems in any order.

Bacon, B. J.; Schmidt, D. K.

1984-01-01

335

Francis H. Smith: architect of antebellum southern military schools and educational reform  

E-print Network

. This chapter will demonstrate how Smith’s treatment of such issues such as cadet finances, hazing, student rebellions, in loco parentis, cadet punishment, parental influence, and faculty 9 relations set a unique standard for other college presidents... for support in the legislature. Conversely, state politicians used their appointment of cadets from their district in order to gain political capital and patronage amongst their constituents. Cadets, particularly those receiving free tuition, represented...

Wineman, Bradford Alexander

2006-10-30

336

IMC based automatic tuning method for PID controllers in a Smith predictor configuration  

Microsoft Academic Search

In this paper, a new approach is presented based on relay autotuning of a plant to find parameters for its control using a Smith predictor. A Smith predictor configuration is represented as its equivalent internal model controller (IMC) which provides the parameters of the proportional-integral (PI) or proportional-integral-derivative (PID) controller to be defined in terms of the desired closed-loop time

Ibrahim Kaya

2004-01-01

337

Peroxisomal cholesterol biosynthesis and Smith-Lemli-Opitz syndrome  

SciTech Connect

Smith-Lemli-Opitz syndrome (SLOS), caused by 7-dehydrocholesterol-reductase (DHCR7) deficiency, shows variable severity independent of DHCR7 genotype. To test whether peroxisomes are involved in alternative cholesterol synthesis, we used [1-{sup 14}C]C24:0 for peroxisomal {beta}-oxidation to generate [1-{sup 14}C]acetyl-CoA as cholesterol precursor inside peroxisomes. The HMG-CoA reductase inhibitor lovastatin suppressed cholesterol synthesis from [2-{sup 14}C]acetate and [1-{sup 14}C]C8:0 but not from [1-{sup 14}C]C24:0, implicating a peroxisomal, lovastatin-resistant HMG-CoA reductase. In SLOS fibroblasts lacking DHCR7 activity, no cholesterol was formed from [1-{sup 14}C]C24:0-derived [1-{sup 14}C]acetyl-CoA, indicating that the alternative peroxisomal pathway also requires this enzyme. Our results implicate peroxisomes in cholesterol biosynthesis but provide no link to phenotypic variation in SLOS.

Weinhofer, Isabelle [Center for Brain Research, Medical University of Vienna, Vienna (Austria); Kunze, Markus [Center for Brain Research, Medical University of Vienna, Vienna (Austria); Stangl, Herbert [Department of Medical Chemistry, Medical University of Vienna, Vienna (Austria); Porter, Forbes D. [National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD (United States); Berger, Johannes [Center for Brain Research, Medical University of Vienna, Vienna (Austria)]. E-mail: johannes.berger@meduniwien.ac.at

2006-06-23

338

The Futility of Utility: how market dynamics marginalize Adam Smith  

E-print Network

Econometrics is based on the nonempiric notion of utility. Prices, dynamics, and market equilibria are supposed to be derived from utility. Utility is usually treated by economists as a price potential, other times utility rates are treated as Lagrangians. Assumptions of integrability of Lagrangians and dynamics are implicitly and uncritically made. In particular, economists assume that price is the gradient of utility in equilibrium, but I show that price as the gradient of utility is an integrability condition for the Hamiltonian dynamics of an optimization problem in econometric control theory. One consequence is that, in a nonintegrable dynamical system, price cannot be expressed as a function of demand or supply variables. Another consequence is that utility maximization does not describe equiulibrium. I point out that the maximization of Gibbs entropy would describe equilibrium, if equilibrium could be achieved, but equilibrium does not describe real markets. To emphasize the inconsistency of the economists' notion of 'equilibrium', I discuss both deterministic and stochastic dynamics of excess demand and observe that Adam Smith's stabilizing hand is not to be found either in deterministic or stochastic dynamical models of markets, nor in the observed motions of asset prices. Evidence for stability of prices of assets in free markets simply has not been found.

Joseph L. McCauley

1999-11-18

339

A Review of "The Key of Green: Pasion and Perception in Renaissance Culture" by Bruce R. Smith  

E-print Network

tions portray, imply, and refer to the use of curtains, arrases, tapestries, painted cloths, traverses, hangings. Looking for sights corresponding to sounds he listened for in ?Within the Wooden O,? Smith expands insights gleaned from these early... involvement account for more colorful, conflicted, ambigu- ous, human perceptions. Smith?s predominant evidence comes from textiles and texts, two kinds of weavings. Textiles appear mainly in galleries and closets displaying marvels or encouraging contempla...

Clark, Ira

2009-01-01

340

Searching for Dark Matter Annihilation in the Smith High-Velocity Cloud  

E-print Network

Recent observations suggest that some high-velocity clouds may be confined by massive dark matter halos. In particular, the proximity and proposed dark matter content of the Smith Cloud make it a tempting target for the indirect detection of dark matter annihilation. We argue that the Smith Cloud may be a better target than some Milky Way dwarf spheroidal satellite galaxies and use gamma-ray observations from the Fermi Large Area Telescope to search for a dark matter annihilation signal. No significant gamma-ray excess is found coincident with the Smith Cloud, and we set strong limits on the dark matter annihilation cross section assuming a spatially-extended dark matter profile consistent with dynamical modeling of the Smith Cloud. Notably, these limits exclude the canonical thermal relic cross section ($\\sim 3\\times10^{-26}{\\rm cm}^{3}{\\rm s}^{-1}$) for dark matter masses $\\lesssim 30$ GeV annihilating via the $b \\bar b$ or $\\tau^{+}\\tau^{-}$ channels for certain assumptions of the dark matter density profile; however, uncertainties in the dark matter content of the Smith Cloud may significantly weaken these constraints.

Alex Drlica-Wagner; German A. Gomez-Vargas; John W. Hewitt; Tim Linden; Luigi Tibaldo

2014-05-05

341

Smith-Lemli-Opitz syndrome: Objective assessment of facial phenotype.  

PubMed

Smith-Lemli-Opitz syndrome (SLOS), is an autosomal recessive condition caused by cholesterol synthesis deficiency which results in a wide phenotypic spectrum which includes multiple malformations, distinctive facial appearance, and intellectual disability. This anthropometric and observational study was carried out to define the key facial characteristics of individuals with SLOS and to evaluate evolution of the facial phenotype with age. Clinical photographs were obtained on 51 subjects with SLOS and standardized facial anthropometry was performed on 42; the ages ranged from 6 months to 20 years. For each individual, 22 standardized cranial and facial measurements were obtained and compared to published age- and sex-matched controls. Craniofacial pattern profiles were compared between sexes, various age groups, plasma cholesterol concentration at the time of diagnosis, and physical severity score. Mean-Z, a measurement of overall facial size, and craniofacial variability index (CVI), a summary anthropometric measure of craniofacial deviation from the norm, were calculated and compared according to methods published previously. A characteristic craniofacial pattern profile was universally present: narrow forehead, brachycephaly, short palpebral fissures, short nasal ridge, anteverted nares, flat face, normal jaw width, and retrognathia. The facial measurements of subjects with SLOS had higher deviations from the norm with mean CVI of 2.11; SD = 0.47 (controls: Mean = 0.76, SD = 0.19; <0.0001) than age- and sex-matched controls. Their faces were also smaller than controls: 70% of subjects had mean-Z values 2 SD below the mean for controls; average Z-score was -1.64; SD = 0.85 (controls: mean = 0, SD = 0.64; <0.0001). There were no significant differences in the craniofacial pattern profile between the sexes or clinical severity as measured by either plasma cholesterol level at the time of diagnosis or the physical severity score. Patients with a lower weight at the time of assessment and patients with higher physical severity score had higher CVI measures (P < 0.001 and P < 0.002, respectively), suggesting that the degree of deviation from craniofacial norms is a function of the overall physical severity. PMID:22438180

Nowaczyk, Ma?gorzata J M; Tan, Mattea; Hamid, Jemila S; Allanson, Judith E

2012-05-01

342

VizieR Online Data Catalog: Optical and UV colors of Coma galaxies (Smith+, 2012)  

NASA Astrophysics Data System (ADS)

Our approach is to measure UV/optical colours for galaxies drawn from a catalogue of galaxies with measured spectroscopic ages and metallicities. Full details of the spectroscopy are given in related papers (Smith et al. 2012MNRAS.419.3167S; Smith et al., in preparation). Broadly the parent sample comprises spectra for 242 bright Coma cluster members from SDSS (analysed in Price et al. 2010, Cat. J/MNRAS/411/2558) and 169 fainter members observed using long integrations with Hectospec at the 6.5-m MMT. The MMT sample is an extended version of that reported by Smith et al. (2009, cat. J/MNRAS/392/1265). Velocity dispersions were compiled from a variety of literature sources, supplemented with new observations from VLT/FLAMES, and combined using observations from multiple data sources to determine relative systematic offsets. (2 data files).

Smith, R. J.; Lucey, J. R.; Carter, D.

2013-03-01

343

Geology, paleoclimatology and the evolution of the kidney: some explorations into the legacy of Homer Smith.  

PubMed

The aim of this review is to perform an overview of the relation between kidney development in different species and new developments in plate tectonics and paleoclimatology, which likely had a remarkable effect on evolution. The review follows the ideas of Homer Smith, but adds new data on the subjects which were unknown in Homer Smith's time. The structure and function of the kidney are a result of hundreds of millions of years of evolution, in which adaptations had to be made in response to environmental demands while maintaining the kidney's integrated function. The ideas of Homer Smith have greatly contributed to our understanding of this process, and continue to be of relevance both for researchers as well as physicians working in the field of kidney disease. PMID:22572704

Kooman, Jeroen P

2012-01-01

344

Doppler Simulation and the LeslieDoppler Simulation and the Leslie Julius Smith,Julius Smith, Stefania SerafinStefania Serafin Jonathan Abel, DavidJonathan Abel, David BernersBerners  

E-print Network

1 Doppler Simulation and the LeslieDoppler Simulation and the Leslie Julius Smith,Julius Smith,,dpbernerdpberner@@uaudiouaudio.com.com Universal AudioUniversal Audio Santa Cruz, CASanta Cruz, CA OverviewOverview The LeslieThe Leslie Doppler and Leslie effectDoppler and Leslie effect Leslie measurementsLeslie measurements Leslie effect simulationLeslie

Smith III, Julius Orion

345

Improve growth rate of Smith-Purcell free-electron laser by Bragg reflector  

SciTech Connect

Grating with Bragg reflectors for the Smith-Purcell free-electron laser is proposed to improve the reflection coefficient, resulting in enhancing the interaction of the surface wave with the electron beam and, consequently, relax the requirements to the electron beam. With the help of particle-in-cell simulations, it has been shown that the usage of Bragg reflectors may improve the growth rate, shorten the time for the device to reach saturation, and lower the start current for the operation of a Smith-Purcell free-electron laser.

Li, D.; Imasaki, K. [Institute for Laser Technology, Suita, Osaka 565-0871 (Japan); Yang, Z. [Institute of High Energy Electronics, University of Electronic Science and Technology of China, Chengdu 610054 (China); Tsunawaki, Y. [Department of Electronics, Information and Communication Engineering, Osaka Sangyo University, Osaka 574-8530 (Japan); Asakawa, M. R. [Department of Pure and Applied Physics, Faculty of Engineering Science, Kansai University, Osaka 64-8680 (Japan); Hangyo, M. [Institute of Laser Engineering, Osaka University, Suita, Osaka 565-0871 (Japan); Miyamoto, S. [Laboratory of Advanced Science and Technology for Industry, University of Hyogo, Ako, Hyogo 678-1205 (Japan)

2011-05-23

346

Growth retarding effects of paclobutrazol and RSW 0411 on Granny Smith and Fuji apple trees  

Microsoft Academic Search

The growth retardants paclobutrazol (?-[(4-chlorophenyl)methyl]-?-(1,1-dimethylethyl)-1H-1,2,4-triazole-1-ethanol) and RSW\\u000a 0411 (?-(cyclohexyl methylene)-?-(1,1-dimethylethyl)-1H-1,2,4-triazole-1-ethanol) were tested on two-year-old trees of Granny\\u000a Smith and Fuji apple. RSW 0411 at 100 mg\\/L did not cause any growth reduction in Granny Smith, while 500 and 1000 mg\\/L significantly\\u000a reduced growth below that of the control between 27 and 40 days after application. Paclobutrazol at 100 mg\\/L had

D. E. Irving; J. C. Pallesen

1989-01-01

347

A revised method for estimating oxide basicity per the smith scale, with example application to glass durability  

Microsoft Academic Search

Previous researchers have developed correlations between oxide electronegativity and oxide basicity. The present paper revises those correlations using a newer method of calculating electronegativity of the oxygen anion. Basicity is expressed using the Smith ? parameter scale. A linear relation was found between the oxide electronegativity and the Smith ? parameter, with an R2 of 0.92. An example application of

Jacob G. Reynolds

2011-01-01

348

AR Ins. Lic. #245544 CA Ins. Lic. #0633005 d/b/a in CA Seabury & Smith Insurance Program Management  

E-print Network

Management 68186A (8/13) ©Seabury & Smith, Inc. 2013 · 877-249-7868 Healthcare reform is in fullAR Ins. Lic. #245544 · CA Ins. Lic. #0633005 d/b/a in CA Seabury & Smith Insurance Program situation. learn more Stay tuned for more healthcare reform communication. In the meantime, please call

Miami, University of

349

Revisiting "No Easy Answers": Application of Sally Smith's Methods in the Lab School of Washington High School Program  

ERIC Educational Resources Information Center

The first edition of "No Easy Answers" (Smith, 1995) was published in 1979, thirty years ago. That seminal work is as relevant today as it was when the book first appeared. This article provides a description of how Sally Smith's Academic Club Method is implemented in the High School program of The Lab School of Washington.

Reynolds, Meredith

2010-01-01

350

200 Jahre Darwin und 250 Jahre Theory of Moral Sentiments von Adam Smith: Zur Aktualität eines vergessenen Werkes  

Microsoft Academic Search

The author emphasizes that 2009 must be remembered not only for the 200 birthday of Charles Darwin, but as well as the 250-year anniversary of Adam Smith’s “Theory of Moral Sentiments”. Proceeding from the fact that Darwin as well as Robert Malthus refer to a classical economist, it is investigated whether the analogies between Evolution Theory and Economy are justified.

Gerold Bluemle

2009-01-01

351

77 FR 442 - Changes To Implement Miscellaneous Post Patent Provisions of the Leahy-Smith America Invents Act  

Federal Register 2010, 2011, 2012, 2013

...0651-AC66 Changes To Implement Miscellaneous Post Patent Provisions of the Leahy-Smith...reexamination, inter partes review, and post grant review. The Leahy-Smith America...reexamination based on an inter partes review or post grant review proceeding. The Office...

2012-01-05

352

Squaraine-Derived Rotaxanes: Sterically Protected Fluorescent Near-IR Dyes Easwaran Arunkumar, Christopher C. Forbes, Bruce C. Noll, and Bradley D. Smith*  

E-print Network

, Christopher C. Forbes, Bruce C. Noll, and Bradley D. Smith* Department of Chemistry and Biochemistry, UniVersity of Notre Dame, Notre Dame, Indiana 46556 Received December 17, 2004; E-mail: smith.115@nd.edu Fluorescent

Smith, Bradley D.

353

WATTS THEOREM FOR SCHEMES: PRELIMINARY VERSION A. NYMAN AND S. P. SMITH  

E-print Network

WATTS THEOREM FOR SCHEMES: PRELIMINARY VERSION A. NYMAN AND S. P. SMITH Abstract. We describe obstructions vanish and we recover Watts Theorem. We use our description of these obstructions to prove. Introduction 2 2. Watts Theorem 4 3. Basechange, the Projection Formula, and Compatibilities 8 4. Totally

Bardsley, John

354

Prospects for CFD on Petaflops Systems David E. Keyes, Dinesh K. Kaushik, and Barry F. Smith  

E-print Network

1 Prospects for CFD on Petaflops Systems David E. Keyes, Dinesh K. Kaushik, and Barry F. Smith the many possible bottlenecks to CFD on petaflops systems. After a general outline of the problems contribution by the same authors to appear in CFD Review 1997, M. Hafez, ed., Wiley, 1997. Keyes is Associate

355

Prospects for CFD on Petaflops Systems David E. Keyes, Dinesh K. Kaushik, and Barry F. Smith  

E-print Network

1 Prospects for CFD on Petaflops Systems David E. Keyes, Dinesh K. Kaushik, and Barry F. Smith the many possible bottlenecks to CFD on petaflops systems. After a general outline of the problems by the same authors to appear in CFD Review 1997, M. Hafez, ed., Wiley, 1997. Keyes is Associate Professor

356

The Perceived Significance of Suicide in Male vs. Female Breadwinners Steven M. Smith 1  

E-print Network

, read a vignette about a family who experiences a suicide, followed by a reevaluation of the PANAS a strong foundation for the family) than the female suicide (i.e. accepting the breadwinner role and beingThe Perceived Significance of Suicide in Male vs. Female Breadwinners Steven M. Smith 1 1

Zhou, Yaoqi

357

Re-imagining America: Jeff Smith, Herman Melville, and national dreamscapes  

Microsoft Academic Search

A recurring gag in Jeff Smith's acclaimed graphic novel series Bone (1991–2004) is that Moby-Dick (1851) is a snoozer. But, as we argue, Herman Melville's masterpiece puts other characters to sleep not because it is dull but because its most ardent advocate – protagonist Fone Bone himself – is a New Critic bent on divorcing the novel from the context

Jennifer A. Hughes; Philip Nel

2012-01-01

358

‘Blueprint for a revolution’? The politics of the Adam Smith institute  

Microsoft Academic Search

Elite centred, its target audience decision?makers in Whitehall and Westminister, the Adam Smith Institute is as much a political actor as it is a genuine think tank. It has no wish to study the world in a detached scholarly fashion but offers instead normative policy recommendations based upon strict partisan world view. An organised advocate for the free market the

Richard Heffernan

1996-01-01

359

Analysis of the Sensory Profile in Children with Smith-Magenis Syndrome  

ERIC Educational Resources Information Center

This study systematically assessed sensory processing in 34 children, aged 3-14 years, with Smith-Magenis syndrome (SMS) using the Sensory Profile Caregiver Questionnaire. Scores for the SMS cohort were significantly different from scores of the national sample of children with and without disabilities in all Sensory Profile categories and…

Hildenbrand, Hanna L.; Smith, Ann C. M.

2012-01-01

360

Cryptographic Support in a Gigabit Network Jonathan M. Smith (jms@aurora.cis.upenn.edu)  

E-print Network

Cryptographic Support in a Gigabit Network Jonathan M. Smith (jms@aurora.cis.upenn.edu) C. Brendan S. Traw (traw@aurora.cis.upenn.edu) David J. Farber (farber@cis.upenn.edu) Distributed Systems boards were built to understand architectural issues in providing crypto- graphic support for the AURORA

Smith, Jonathan M.

361

Collection Development Statement for the Reference Collection of the Ethel K. Smith Library, Wingate University.  

ERIC Educational Resources Information Center

This document is a statement of guidelines for the collection of reference materials at the Ethel K. Smith Library in Wingate University (North Carolina). The library's mission statement is given at the outset. Then parameters are established for the reference collection's scope and size, including subject-area and media priorities. The statement…

Wetherbee, James M.

362

Conservation rates: the best `new' source of urban water during William James Smith Jr.1  

E-print Network

Conservation rates: the best `new' source of urban water during drought William James Smith Jr.Ã?1-side management; drought; environmental justice; sustainable development; water conservation; water rates; urban In the United States, water conservation-oriented rates (WCOR) are an increasingly vital tool for promoting

Delaware, University of

363

Doppler Simulation and the Leslie Julius O. Smith III Stefania Serafin Jonathan Abel Dave Berners  

E-print Network

Doppler Simulation and the Leslie Julius O. Smith III Stefania Serafin Jonathan Abel Dave Berners simulator is used to simulate a rotating horn to achieve the Leslie effect. Measurements of a horn from a real Leslie are used to calibrate angle-dependent digital filters which simulate the changing, angle

Smith III, Julius Orion

364

On The Ten Point Wood-Desargues' Configuration Christopher J Bradley and Geoff C Smith  

E-print Network

1 Article 6 On The Ten Point Wood-Desargues' Configuration Christopher J Bradley and Geoff C Smith Abstract The ten pairs of directly similar triangles in perspective in the Wood-Desargues' configuration are similar to the five cyclic quadrangles of the initial Wood-Desargues' configuration and that these five

Smith, Geoff

365

Feb. 26, 2009 Susan Lampert Smith (608) 262-7335 ssmith5@uwhealth.org  

E-print Network

1 Feb. 26, 2009 Susan Lampert Smith (608) 262-7335 ssmith5@uwhealth.org Meditation in the Prisons: Can it make lasting change? MADISON -- Can meditation transform the hearts and minds of violent intensive meditation retreat offered at a U.S. prison. Panelists include Jenny Phillips, cultural

Wisconsin at Madison, University of

366

UTILIZING GOOGLE EARTH AS A GIS PLATFORM FOR WEATHER APPLICATIONS Travis M. Smith1,2  

E-print Network

UTILIZING GOOGLE EARTH AS A GIS PLATFORM FOR WEATHER APPLICATIONS Travis M. Smith1,2 and Valliappa Lakshmanan1,2 1 U. of Oklahoma/CIMMS; 2 NOAA/NSSL 1. Introduction Google Earth (formerly known as Keyhole; http://earth.google.com) is a free-for- personal-use application that streams high- resolution static

Smith, Travis

367

fMRI measurements of color in macaque and human Smith-Kettlewell Eye Research Center,  

E-print Network

fMRI measurements of color in macaque and human Smith-Kettlewell Eye Research Center, San Francisco observations. Firstly, the relative amplitudes of responses to color and luminance stimuli in macaque area V1: color vision, functional imaging, visual cortex, color appearance/constancy Citation: Wade, A., Augath

Wandell, Brian A.

368

Tuning RED for Web Traffic * Mikkel Christiansen, ** Kevin Jeffay, David Ott, F. Donelson Smith  

E-print Network

139 Tuning RED for Web Traffic * Mikkel Christiansen, ** Kevin Jeffay, David Ott, F. Donelson Smith http://www.cs.unc.edu/Research/dirt Abstract We study the effects of RED on the performance of Web --- response time for HTTP request­response pairs. We empirically evaluate RED across a range of parameter

Jeffay, Kevin

369

The sodium tail of the Moon M. Matta a,b,*, S. Smith a,1  

E-print Network

The sodium tail of the Moon M. Matta a,b,*, S. Smith a,1 , J. Baumgardner a,1 , J. Wilson a,1 , C 2009 Available online xxxx Keywords: Moon Meteors Solar wind Solar radiation Image processing a b s t r a c t During the few days centered about new Moon, the lunar surface is optically hidden from Earth

Mendillo, Michael

370

Publications Princz, P., S. Smith, K. Hatfield and J. Olah. "Improvement of the Biological  

E-print Network

and H. Herbert (eds.), NATO Science for Peace Program Publication. 2003. Smith, S. "Mapping of the Soil-Scale Wetland Composition Using High Resolution Imagery and Texture Features, International Journal of Applied, B. "A Tool for Rapid Post-Hurricane Urban Tree Debris Estimates Using High Resolution Aerial Imagery

Hill, Jeffrey E.

371

Operation regimes of Cerenkov-Smith-Purcell free electron lasers and T.W. amplifiers  

Microsoft Academic Search

We present a unified linear analysis which describes free electron lasers based on Cerenkov and Smith-Purcell effects and T.W. amplifiers. In the single electron interaction regime the analysis reproduces the exponential and non exponential (interferential) gain expressions. It is shown that the first expression is dominant and that considerable increase in the gain can be attained by using electron beams

Avraham Gover; Zohar Livni

1978-01-01

372

THE ROLE OF XBT SAMPLING IN THE OCEAN THERMAL NETWORK Neville R. SMITH 1  

E-print Network

the focus is on XBT sampling the paper restricts its scope to the upper ocean, mostly above 1000 mTHE ROLE OF XBT SAMPLING IN THE OCEAN THERMAL NETWORK Neville R. SMITH 1 , D.E. HARRISON 2 , Rick Research, Castray Esplanade, Hobart Tas. 3001, AUSTRALIA 9 NOAA/AOML, 4301 Rickenbacker Causeway, Miami, FL

373

Celebrating the Past, Ensuring the Future--A Profile of President Glenn Smith  

ERIC Educational Resources Information Center

"I had no idea how to convince someone to hire me," recalls APPA President, Glen Smith. His first interview was with Bryn Mawr College, a small, prestigious private college with Quaker roots, located 12 miles west of Philadelphia. That was in 1997, after 24 years in the Naval Civil Engineer Corps, and he still remembers a certain…

Blumenthal, Anita

2013-01-01

374

Sally Smith's Arts-Based and Integrated Curricular Approach to Educating Students with Learning Disabilities  

ERIC Educational Resources Information Center

Founded in 1967, The Lab School of Washington (LSW) has been educating students with learning disabilities using an arts-based curriculum for over 50 years. Sally Smith originally started the school out of frustration with the inability of traditional educational environments to reach her intelligent, but learning disabled, young son and others…

Durham, Jennifer

2010-01-01

375

LIFE HISTORY MONITORING OF SALMONIDS IN THE WEST FORK SMITH RIVER, UMPQUA BASIN, OREGON  

EPA Science Inventory

As a life-cycle monitoring basin for the Oregon Salmon Plan, the Oregon Department of Fish and Wildlife has estimated adult returns, distribution and smolt outmigration of coho, chinook and winter steelhead in the West Fork Smith River since 1998. In 2001/2002, the Environmenta...

376

ESTIMATION OF SURPLUS BIOMASS OF CLUPEIDS IN SMITH MOUNTAIN LAKE, VIRGINIA  

EPA Science Inventory

Mean annual estimates of surplus biomass of alewife Alosa pseudoharengus and gizzard shad Dorosoma cepedianum in Smith Mountain Lake, Virginia, were calculated using data on the biomass, growth, and mortality of each clupeid species. Surplus biomass, defined as production over a...

377

Sally L. Smith: A Genius at Seeing the Potential in People  

ERIC Educational Resources Information Center

What this author admired most about Sally Smith was the fact that she was a visionary about people and what they could accomplish. She saw more potential in a person--young or old--than anybody or even they themselves, frankly, had ever even considered possible. She was a genius at seeing the potential in people, expecting them to find it in…

Edgerton, Mary Allen

2010-01-01

378

Another Look at the Glass and Smith Study on Class Size  

ERIC Educational Resources Information Center

One of the most influential studies affecting educational policy is Glass and Smith's 1978 study, "Meta-Analysis of Research on the Relationship of Class-Size and Achievement." Since its publication, educational policymakers have referenced it frequently as the justification for reducing class size. While teachers and the public had long believed…

Phelps, James L.

2011-01-01

379

EFFECTS OF SOME TRACE ELEMENTS ON THE BLOOD OF KUWAIT MULLETS 'LIZA MACROLEPS' (SMITH)  

EPA Science Inventory

Haemopathological changes attributed to heavy metal poisoning observed in blood smears of Liza macrolepis (Smith) taken after exposures of 96 h to graded doses (mg/l) of copper (0.11-1.80), lead (1.15-18.36), and mercury (0.04-0.59), in a flow-through marine bioassay system. In g...

380

Synthesis of a Parallel Smith-Waterman Sequence Alignment Kernel into FPGA Hardware  

E-print Network

the issue of making FPGA- based co-processors accessible to systems biologists who do not have an extensive to exploit FPGA-based co-processors to compute operations like DNA sequence matching without a requirementSynthesis of a Parallel Smith-Waterman Sequence Alignment Kernel into FPGA Hardware David Greaves

Greaves, David J.

381

Airlift Mission Monitoring and Dynamic Rescheduling David E. Wilkins, Stephen F. Smith, Laurence A. Kramer,  

E-print Network

. Kramer, Thomas J. Lee and Timothy W. Rauenbusch Wilkins, Lee, Rauenbusch: Smith, Kramer: Artificial, weather, airport operations, aircraft status) and recognition of those situations that require correc regularly forces changes. Aircraft break down, airports become unavailable due to weather, missions become

Wilkins, David E.

382

77 FR 12324 - Captain John Smith Chesapeake National Historic Trail Advisory Council  

Federal Register 2010, 2011, 2012, 2013

...Virginia, Maryland, Delaware, and in the District of Columbia,'' tracing the 1607-1609 voyages of Captain John Smith to chart the land and waterways of the Chesapeake Bay. This meeting is open to the public. Preregistration is required for both...

2012-02-29

383

76 FR 26767 - Captain John Smith Chesapeake National Historic Trail Advisory Council  

Federal Register 2010, 2011, 2012, 2013

...Virginia, Maryland, Delaware, and in the District of Columbia,'' tracing the 1607-1609 voyages of Captain John Smith to chart the land and waterways of the Chesapeake Bay. This meeting is open to the public. Preregistration is required for both...

2011-05-09

384

76 FR 52691 - Captain John Smith Chesapeake National Historic Trail Advisory Council  

Federal Register 2010, 2011, 2012, 2013

...Virginia, Maryland, Delaware, and in the District of Columbia,'' tracing the 1607-1609 voyages of Captain John Smith to chart the land and waterways of the Chesapeake Bay. This meeting is open to the public. Preregistration is required for both...

2011-08-23

385

77 FR 64352 - Notice of Meeting for Captain John Smith Chesapeake National Historic Trail Advisory Council  

Federal Register 2010, 2011, 2012, 2013

...Virginia, Maryland, Delaware, and in the District of Columbia,'' tracing the 1607-1609 voyages of Captain John Smith to chart the land and waterways of the Chesapeake Bay. This meeting is open to the public. Preregistration is required for both...

2012-10-19

386

77 FR 2317 - Captain John Smith Chesapeake National Historic Trail Advisory Council  

Federal Register 2010, 2011, 2012, 2013

...Virginia, Maryland, Delaware, and in the District of Columbia,'' tracing the 1607-1609 voyages of Captain John Smith to chart the land and waterways of the Chesapeake Bay. This meeting is available to the public through a toll-free call-in...

2012-01-17

387

Multi-objective Buffer Allocation Cruz, van Woensel & Smith Buffer and throughput trade-offs in  

E-print Network

Multi-objective Buffer Allocation Cruz, van Woensel & Smith Buffer and throughput trade-offs in M. For example, one conflicting pair of objectives includes first minimizing the overall number of buffers and then maximizing throughput. In this paper, we present an original methodology to solve a buffer alloca- tion

Cruz, Frederico

388

BUFFER SIZINGATA HOST IN AN ATM NETWORK DONALD E. SMITH and H. JONATHAN CHAO  

E-print Network

BUFFER SIZINGATA HOST IN AN ATM NETWORK DONALD E. SMITH and H. JONATHAN CHAO Bellcore 331 Newman Springs Rd., Red Bank, NJ 07701-7030,USA ABSTRACT. This paper develops a queueing model of a buffer that collects cells for reassembly into packets for a protocol layer above the ATM layer. Whenever the buffer

Chao, Jonathan

389

Multi-server buffer allocation Smith, Cruz, & van Woensel Topological Network Design of General,  

E-print Network

Multi-server buffer allocation Smith, Cruz, & van Woensel Topological Network Design of General the performance of these queueing net- works and an iterative search methodology to find the op- timal buffer allocation within the network. The coefficient of variation is shown to be a significant factor in the buffer

Cruz, Frederico

390

Book review Forestry and Climate Change, P.H. Freer-Smith, M.S.J.  

E-print Network

Book review Forestry and Climate Change, P.H. Freer-Smith, M.S.J. Broadmeadow, J.M. Lynch, CAB International, Wallingford, UK(2007), 253 pp., £70, ISBN-978 1 84593 294 7 (hardback) Who would have thought of acrimonious disputes and of hot debates in international negotiations? And yet, 11 years after the agreement

Mencuccini, Maurizio

391

Nematodes and Regulatory T Cells Katherine A Smith and Rick M Maizels  

E-print Network

Nematodes and Regulatory T Cells Katherine A Smith and Rick M Maizels Institute of Immunology and Infection Research University of Edinburgh, Edinburgh, EH9 3JT, UK For "Parasitic Nematodes, Second Edition.maizels@ed.ac.uk #12;Smitn & Maizels, Nematodes and T Regulatory Cells Page 2 Introduction The survival of nematode

Maizels, Rick

392

A Case Study of Early Development in Smith-Magenis Syndrome  

ERIC Educational Resources Information Center

The aim of this article is to provide an in-depth description of early development in a young child with Smith-Magenis syndrome (SMS). SMS is a multisystem, neurodevelopmental genetic disorder associated with mental retardation that predisposes individuals to a distinct pattern of maladaptive behaviors and other neuropsychological impairments.…

Fidler, Deborah J.; Philofsky, Amy D.; Hepburn, Susan L.

2006-01-01

393

Smith, Higgin, and Raines Supplementary Data Site-specific folate conjugation to a cytotoxic protein  

E-print Network

DNA Synthesis S4 References and Notes S5 1 H NMR Spectrum of Folate Analogue 1 #12;Smith, Higgin and 6-TAMRA is a 3# 6-carboxytetramethylrhodamine group), was from Integrated DNA Technologies to a thick dark viscous liquid that was dripped into benzene (150 mL). The precipitate was filtered, washed

Raines, Ronald T.

394

SPECTRA OF COHERENT SMITH-PURCELL RADIATION OBSERVED FROM SHORT ELECTRON BUNCHES  

E-print Network

, University of Oxford, Keble road, OX1 3RH, UK R. J.D.A. Smith, Tech-X UK Ltd., Daresbury Innovation Centre that are capable of measuring a single femtosecond electron bunch are required. At the current stage such beam field region the wavelength of the emitted radiation detected is a function of the angle between

Paris-Sud XI, Université de

395

THE STRONG TEST IDEAL Nobuo Hara y and Karen E. Smith \\Lambda  

E-print Network

THE STRONG TEST IDEAL Nobuo Hara y and Karen E. Smith \\Lambda Let R be a Noetherian commutative ring containing a field. The test ideal, introduced by Hochster and Huneke in [HH1], has emerged as an important object associated to R. The test ideal can be defined as the largest ideal J of R such that JI

Smith, Karen E.

396

Latent Theoretical Convergence upon a Pluralist Conception of Economic Action: Adam Smith and Max Weber  

Microsoft Academic Search

This paper engages in exploring certain latent theoretical convergences between the works of Adam Smith and Max Weber. The fact that these two have been major protagonists in the establishment and development of political economy and sociology respectively gives a rationale to such an endeavor. Another rationale is provided by the paucity of attempts at exploring the theoretical relations between

Milan Z. Zafirovski

2000-01-01

397

A Fast Las Vegas Algorithm for Computing the Smith Normal Form of a Polynomial Matrix  

E-print Network

equations over the domain of entries [4], integer programming [9], determining the canon- ical decomposition for rational functions, plays an important role in linear systems theory [10]. The Smith normal form is well[x]nÃ?n if there exists a unimodular matrix U such that UA = H with H upper triangular, each diagonal entry monic

Labahn, George

398

A Fast Las Vegas Algorithm for Computing the Smith Normal Form of a Polynomial Matrix  

E-print Network

equations over the domain of entries 4], integer programming 9], determining the canon- ical decomposition form, the Smith-MacMillan form for rational functions, plays an important role in linear systems theory A 2 F x]n n if there exists a unimodular matrix U such that UA = H with H upper triangular, each

Waterloo, University of

399

Pigeons' categorization may be exclusively nonanalytic J. David Smith & F. Gregory Ashby & Mark E. Berg &  

E-print Network

Pigeons' categorization may be exclusively nonanalytic J. David Smith & F. Gregory Ashby & Mark E, the researchers applied this theoretical distinction to pigeons' category learning. Pigeons learned to categorize information-integration tasks, pigeons learned the two tasks equally quickly to the same accuracy level

Cook, Robert

400

CUDA compatible GPU cards as efficient hardware accelerators for Smith-Waterman sequence alignment  

Microsoft Academic Search

BACKGROUND: Searching for similarities in protein and DNA databases has become a routine procedure in Molecular Biology. The Smith-Waterman algorithm has been available for more than 25 years. It is based on a dynamic programming approach that explores all the possible alignments between two sequences; as a result it returns the optimal local alignment. Unfortunately, the computational cost is very

Svetlin A Manavski; Giorgio Valle

2008-01-01

401

Coulomb stress accumulation along the San Andreas Fault system Bridget Smith and David Sandwell  

E-print Network

Coulomb stress accumulation along the San Andreas Fault system Bridget Smith and David Sandwell. [1] Stress accumulation rates along the primary segments of the San Andreas Fault system are computed is then applied to the San Andreas Fault system using published slip rates along 18 major fault strands

Smith-Konter, Bridget

402

Heterogeneous wireless networked control systems based on modify Smith predictor and CMAC-PID control  

Microsoft Academic Search

The cerebellar model articulation controller (CMAC) neural network is a practical tool for improving existing nonlinear control systems, and it can effectively reduce tracking error of control system. In order to effectively restrain the impact of network delays for wireless networked control systems (WNCS), a novel approach is proposed that modified Smith predictor combined with CMAC-PID control for the heterogeneous

Du Feng; Qian Qingquan

2008-01-01

403

Laterally driven interfaces in the three-dimensional Ising lattice gas Thomas H. R. Smith,1  

E-print Network

Laterally driven interfaces in the three-dimensional Ising lattice gas Thomas H. R. Smith,1 Oleg We study the steady state of a phase-separated driven Ising lattice gas in three dimensions using as compared to equilibrium. Pair correlations are more suppressed in the vorticity direction y than

Ott, Albrecht

404

Mountain Precipitation and Hydrology in the Middle East Ronald. B. Smith*, Jason Evans*, Robert Oglesby**  

E-print Network

Mountain Precipitation and Hydrology in the Middle East Ronald. B. Smith*, Jason Evans*, Robert Arabia and Central Asia. In both Europe and southwest Asia, elevated terrains have higher precipitation responsible for the surrounding dry climates. An important aspect of orographic precipitation is the rain

Evans, Jason

405

Has "Wisconsin v. Yoder" Been Reversed? Analysis of "Employment Division v. Smith."  

ERIC Educational Resources Information Center

Compares the Supreme Court ruling in "Employment Division, Department of Human Resources of Oregon v. Smith," involving the denial of unemployment compensation to two employees discharged because they ingested peyote, to "Wisconsin v. Yoder," mandating exemption to Amish parents of the state's uniformly applied compulsory attendance statute. (MLF)

Mawdsley, Ralph D.

1990-01-01

406

Mineralogy and geochemistry of Mariano Lake uranium deposit, Smith Lake district  

Microsoft Academic Search

The Mariano Lake uranium deposit is located on the west side of the Smith Lake district in the Grants mineral belt. Mineralization is restricted to a basal arkosic sandstone of the Brushy Basin Member of the Morrison Formation (Upper Jrassic). This sandstone is equivalent to the Poison Canyon sandstone of the Ambrosia Lake district and contains a series of paleochannels

R. S. Della Valle; D. G. Brookins

1980-01-01

407

Matthew B. Weinger, MD Norman Ty Smith Chair in Patient Safety & Medical Simulation  

E-print Network

of Anesthesiology, Biomedical Informatics & Medical Education Director, Center for Research and InnovationMatthew B. Weinger, MD Norman Ty Smith Chair in Patient Safety & Medical Simulation Professor in Systems Safety Vanderbilt University Medical Center * and years of designing HIT too! Developing

408

Katana: A Hot Patching Framework for ELF Executables Ashwin Ramaswamy, Sergey Bratus, Sean W. Smith  

E-print Network

Katana: A Hot Patching Framework for ELF Executables Ashwin Ramaswamy, Sergey Bratus, Sean W. Smith object file. Our tool, Katana, automatically creates these patch objects as a by-product of the standard source build process. Katana also allows an end-user to apply the Patch Objects to a running process

Smith, Sean W.

409

A Domain Wall Model for Ferroelectric Hysteresis Ralph C. Smith 1 and Craig L. Hom 2  

E-print Network

A Domain Wall Model for Ferroelectric Hysteresis Ralph C. Smith 1 and Craig L. Hom 2 1 Center on the quantification of energy required to bend and translate domain walls and is developed in two steps. In the first the consideration of domain wall motion and the quantification of energy losses due to inherent inclusions

410

Barbara Prudhomme White, Ph.D., OTR/L Paige Smith, OTS  

E-print Network

Barbara Prudhomme White, Ph.D., OTR/L Paige Smith, OTS Department of Occupational Therapy College like to thank: The parents and children for their help in this research. The graduate students in OT885/index.html Conclusions Results Perceptions of stress and health were negatively correlated: Spearman's rho = - .311, p

New Hampshire, University of

411

Describing the Performance of Cricket Bats and Balls Harsimranjeet Singh and Lloyd Smith  

E-print Network

Describing the Performance of Cricket Bats and Balls Harsimranjeet Singh and Lloyd Smith School-2920 USA Nomenclature: BBS Batted-ball speed DS Dynamic stiffness mb Cricket ball mass Fp Peak impact force vi Inbound ball speed ea Collision efficiency vb Cricket bat speed vp Cricket ball speed MOI Moment

Smith, Lloyd V.

412

Effect of obliteration on crater-count chronologies for Martian surfaces Matthew R. Smith,1  

E-print Network

as evidence for young and geologically significant surface activity. Citation: Smith, M. R., A. R. Gillespie in the Mariner/Viking days of Mars exploration but commonly overlooked in recent studies. We present inferred from crater-frequency distributions. Our work affirms that small-crater size distributions can

Montgomery, David R.

413

Effect of meliaceous seed extracts on growth and survival of Spodoptera frugiperda (J.E. Smith)  

Microsoft Academic Search

Hexane and ethanol extracts of seeds from 10 plant species (including neem—Azadirachta indica A. Juss.) of the family Meliaceae were incorporated into artificial diet at various doses and fed to fall armyworm [Spodoptera frugiperda (J. E. Smith) (Lepidoptera: Noctuidae)] larvae in nochoice tests. All produced significant mortality, reduced larval growth rate, increased time to pupation, or all three, at some

K. L. Mikolajczak; B. W. Zilkowski; R. J. Bartelt

1989-01-01

414

Analyzing (Social Media) Networks with NodeXL Marc A. Smith1  

E-print Network

Analyzing (Social Media) Networks with NodeXL Marc A. Smith1 , Ben Shneiderman2 , Natasa Milic with a social media data sample drawn from an enterprise intranet social network. A sequence of Node relevant differences in the patterns of interconnection among employee participants in the social media

Golbeck, Jennifer

415

Loop-wire medium for investigating plasmons at microwave frequencies D. R. Smith,a)  

E-print Network

wavelengths, including the infrared and microwave regimes.3­5 At these longer wavelengths, metals canLoop-wire medium for investigating plasmons at microwave frequencies D. R. Smith,a) D. C. Vier present numerical simulations and microwave measurements on a loop-wire structure that acts

Nemat-Nasser, Sia

416

corresponding author, aguswa@email.smith.edu Meteorology of Monteverde, Costa Rica  

E-print Network

corresponding author, aguswa@email.smith.edu Meteorology of Monteverde, Costa Rica 2006 Technical at the Monteverde Institute (MVI) in Monteverde, Costa Rica records precipitation, temperature, relative humidity Report 3 Guswa and Rhodes, 2007 1 Introduction 1.1 Climate Monteverde, Costa Rica (84°48' W Long., 10

Guswa, Andrew J.

417

corresponding author, aguswa@email.smith.edu Meteorology of Monteverde, Costa Rica  

E-print Network

corresponding author, aguswa@email.smith.edu Meteorology of Monteverde, Costa Rica 2005 Technical at the Monteverde Institute (MVI) in Monteverde, Costa Rica measures precipitation, temperature, wind speed and Rhodes, 2006 1 Introduction 1.1 Climate Monteverde, Costa Rica (84°48' W Long., 10°18' N Lat., see Figure

Guswa, Andrew J.

418

corresponding author, aguswa@email.smith.edu Meteorology of Monteverde, Costa Rica  

E-print Network

corresponding author, aguswa@email.smith.edu Meteorology of Monteverde, Costa Rica 2007 Technical at the Monteverde Institute (MVI) in Monteverde, Costa Rica records precipitation, temperature, relative humidity 1 Introduction 1.1 Climate Monteverde, Costa Rica (84°48' W Long., 10°18' N Lat., see Figure 1) lies

Guswa, Andrew J.

419

Kandler Smith, NREL EDV Battery Robust Design -1 Design of Electric Drive Vehicle  

E-print Network

and energy performance requirements at the end-of-life · HEVs: only 10% to 25% of energy is used · Toyota EDV Battery Robust Design - 5 Performance Life Cost Safety Requirements Multi-Scale Physics in Li for Long Life and Low Cost Robustness to Geographic and Consumer-Usage Variation Kandler Smith* Tony Markel

420

A Study of In-Dorm Student Energy Use at Smith College  

Microsoft Academic Search

Abstract Energy use features prominently in the search for solutions to economic and environmental problems as a major contributor to both climate change and cost of living. Smith College, in Northampton, Massachusetts, has embraced this search. The school committed,itself to neutralizing its greenhouse gas emissions in 2007. Furthermore the school’s recent budget plan includes a goal of funding conservation projects

Britni Steingard; Northampton MA

421

Development and Behaviour in Marshall-Smith Syndrome: An Exploratory Study of Cognition, Phenotype and Autism  

ERIC Educational Resources Information Center

Background: Marshall-Smith syndrome (MSS) is an infrequently described entity characterised by failure to thrive, developmental delay, abnormal bone maturation and a characteristic face. In studying the physical features of a group of patients, we noticed unusual behavioural traits. This urged us to study cognition, behavioural phenotype and…

van Balkom, I. D. C.; Shaw, A.; Vuijk, P. J.; Franssens, M.; Hoek, H. W.; Hennekam, R. C. M.

2011-01-01

422

Monitoring Delayed Systems Using the Smith Predictor Jan Maximilian Montenbruck and Sean Brennan  

E-print Network

. In this paper, a control will be provided that couples a delayed system that has a nonlinear state space of synchronization theory to systems with time delay, a sophisticated method of linear matrix inequalities has beenMonitoring Delayed Systems Using the Smith Predictor Jan Maximilian Montenbruck and Sean Brennan

Brennan, Sean

423

Joint work with Sean Hallgren and Adam Smith Computer Science and Engineering  

E-print Network

Fang Song Joint work with Sean Hallgren and Adam Smith Computer Science and Engineering Penn State: e.g. rewinding · General question: how to reason about quantum adversaries? #12;· Some tasks pairs only differs by "simple" changes: · E.g., changing the plaintext of an encryption · Formalize

Smith, Adam D.

424

Smith Predictor Based Robot Control for Ultrasound-guided Teleoperated Beating-heart Surgery  

E-print Network

, and the mean integrated square error. Index Terms--Beating-heart surgery, Robotic assistance, Ul- trasound1 Smith Predictor Based Robot Control for Ultrasound-guided Teleoperated Beating-heart Surgery, Member, IEEE, Abstract--Performing surgery on fast-moving heart structures while the heart is freely

425

Smith-Purcell radiation from electrons moving parallel to a gratingat oblique incidence to the rulings  

Microsoft Academic Search

Smith-Purcell radiation is produced when a charged particle moves parallel and close to a diffraction grating. We extend previous descriptions of the phenomenon by considering a particle moving parallel to the grating surface at an arbitrary angle with respect to the grating rulings. The problem of calculating the emitted radiation intensity is shown to be linked to a special grating

O. Haeberlé; P. Rullhusen; J.-M. Salomé; N. Maene

1997-01-01

426

Superradiant terahertz Smith-Purcell radiation from surface plasmon excited by counterstreaming electron beams  

Microsoft Academic Search

The authors show that evanescent tunneling transmission of effective surface plasmon polaritons between two counterstreaming electron beams noticeably increases Smith-Purcell radiation (SPR) intensity by about two orders of magnitude as well as lower its transition threshold from a spontaneous emission to a stimulated one. An emission mechanism of the superradiant SPR is theoretically analyzed by the dielectric conversion of the

Young-Min Shin; Jin-Kyu So; Kyu-Ha Jang; Jong-Hyo Won; Anurag Srivastava; Gun-Sik Park

2007-01-01

427

PRINT ONLY: PLANETARY CARTOGRAPHY Smith M. J. Petford N. Xiao L.  

E-print Network

.smith@kingston.ac.uk). 2 Research Center for Space Science and Technology, China University of Geosciences, Wuhan, Hubei, 430074, China. Introduction: Geographic information systems (GIS), and more specifically remote sensing from which further topo- graphic analyses can proceed and will use satellite based photogrammetry

Rathbun, Julie A.

428

Barriers and Promises in STEM Reform Melissa H. Dancy, Johnson C. Smith University  

E-print Network

Barriers and Promises in STEM Reform Melissa H. Dancy, Johnson C. Smith University Charles Henderson, Western Michigan University Introduction There have been many calls for the reform that these reform efforts are having only a marginal impact. For example, as the rationale for its 2003 report

Henderson, Charles

429

A robust Smith predictor modified by internal models for integrating process with dead time  

Microsoft Academic Search

The internal model principle and control together (IMPACT) structure of the Smith predictor is proposed. The structure constructively achieves both the robust stability and absorption of external disturbances. In the structure design, the absorption principle is applied to enable the rejection of arbitrary class of deterministic disturbances and\\/or to suppress the effects of low frequency stochastic external signals on the

M. R. Stojic; F. S. Matijevic; L. S. Draganovic

2001-01-01

430

A unified Smith predictor approach for power system damping control design using remote signals  

Microsoft Academic Search

This brief illustrates a control design procedure for handling time delays encountered in transmitting the remote signals in power systems. A unified Smith predictor (USP) approach is used to formulate the control design problem in the standard mixed sensitivity framework. The solution to the problem is sought numerically using linear matrix inequalities (LMIs) with additional pole-placement constraints. The predictor based

Rajat Majumder; Balarko Chaudhuri; Bikash C. Pal; Qing-Chang Zhong

2005-01-01

431

Two Degree-of-Freedom Smith Predictor for Processes with Time Delay  

Microsoft Academic Search

In this paper, the conventional Smith predictor is modified, which leads to significant improvements in its regulatory capacities for reference inputs and disturbances. The proposed modification utilizes the existing prediction of the conventional time delay compensator and decouples the setpoint response from the disturbance response. The setpoint response and the disturbance response of the closed-loop system are adjusted by two

WEIDONG ZHANG; YOUXIAN SUN; XIAOMING XU

1998-01-01

432

Stress in Families of Young Children with Down Syndrome, Williams Syndrome, and Smith-Magenis Syndrome.  

ERIC Educational Resources Information Center

Compared stress levels in families of children with Down syndrome (DS), Williams syndrome (WS), or Smith-Magenis syndrome (SMS). Found that DS families experienced less Pessimism than others and less Parent and Family Problems than SMS families. Strongest predictors of Parent and Family Problems were maladaptive behavior in SMS, younger age in DS,…

Fidler, Deborah J.; Hodapp, Robert M.; Dykens, Elizabeth M.

2000-01-01

433

A new Smith predictor and controller for unstable and integrating processes with time delay  

Microsoft Academic Search

A new Smith predictor for control of an unstable process with time delay and a process with an integrator and long dead-time is proposed. The controller decouples the setpoint response from the load response. The design approach is based on standard forms of the closed loop system response and on the Nyquist stability analysis. Simulation results show high performance for

S. Majhi; Derek P. Atherton

1998-01-01

434

ATM Rate Based Congestion Control Using a Smith Predictor: An EPRCA Implementation  

Microsoft Academic Search

This paper presents a feedback control algorithmfor ATM congestion control in which source rates areadjusted according to VC queue lengths at intermediatenodes along the path. The goal is to "fill in"the residual bandwidth, without exceeding a specifiedqueue threshold. In order to obtain this, we proposea simple and classical proportional controller, plus aSmith Predictor to overcome instabilities due to largepropagation delays,

Saverio Mascolo; Dirceu Cavendish; Mario Gerla

1996-01-01

435

A new Smith predictor for controlling a process with an integrator and long dead-time  

Microsoft Academic Search

A new Smith predictor for control of a process with an integrator and long dead-time is proposed in this note. The controller decouples the setpoint response from the load response. This simplifies both design and tuning. Simulation results obtained by controlling a typical process show that the new controller has superior performance compared to previous algorithms

K. J. Astrom; C. C. Hang; B. C. Lim

1994-01-01

436

Design the Remote Control System with the Time-Delay Estimator and the Adaptive Smith Predictor  

Microsoft Academic Search

In real applications, a remote control system is generally an integration of different networks consisting of a commercial network for message transmission and an industrial network to control the remote hardware through a communication gateway. Since the induced time-delay in network control system (NCS) may cause system instability, this paper proposes a remote NCS structure by implementing the adaptive Smith

Chien-Liang Lai; Pau-Lo Hsu

2010-01-01

437

Modified Smith predictor scheme for periodic disturbance reduction in linear delay systems  

Microsoft Academic Search

This paper presents a disturbance reduction scheme for linear systems with time delays. The linear systems in the study are assumed to be nominally stable, minimum phase, and relative degree one systems. The proposed scheme is a combination of Astrom’s modified Smith predictor with a disturbance reduction controller and a grey predictor. Unlike conventional disturbance rejection methods, the scheme proposed

Yi-De Chen; Pi-Cheng Tung; Chyun-Chau Fuh

2007-01-01

438

A cascade interpretation of the Smith predictor and the arising enhanced scheme  

Microsoft Academic Search

In this paper we propose a novel interpretation of the well known Smith predictor scheme for dead-time plants. By a suitable change of coordinates, it is revealed that the system possesses a useful cascaded structure wherein extra stabilizing signals can be successfully injected to make the approach applicable to non Hurwitz plants. We emphasize here the potential of this type

L. Zaccarian; D. Nesic

2006-01-01

439

Obtaining controller parameters for a new PI-PD Smith predictor using autotuning  

Microsoft Academic Search

The paper extends a recent work on a modified PI-PD Smith predictor, which leads to significant improvements in the control of processes with large time constants or an integrator or unstable plant transfer functions plus long dead-time for reference inputs and disturbance rejections. Processes with high orders or long time delays are modelled with lower order plant transfer functions with

Ibrahim Kaya

2003-01-01

440

Behavior of Smith predictor in teleoperation systems with modeling and delay time errors  

Microsoft Academic Search

In this paper, behavior of teleoperation systems with modeling error and error of delay time in Smith predictor is discussed. In teleoperation systems usually there is a large distance between master system and slave system. In this case, there is always an error in modeling of system. The condition for stability of teleoperation systems with modeling error is derived by

S. Ganjefar; H. Momeni; F. Janabi Sharifi; M. T. Hamidi Beheshti

2003-01-01

441

Adaptive and Maladaptive Behavior in Children with Smith-Magenis Syndrome  

ERIC Educational Resources Information Center

Children with Smith-Magenis Syndrome (SMS) exhibit deficits in adaptive behavior but systematic studies using objective measures are lacking. This descriptive study assessed adaptive functioning in 19 children with SMS using the Vineland Adaptive Behavior Scales (VABS). Maladaptive behavior was examined through parent questionnaires and the…

Martin, Staci C.; Wolters, Pamela L.; Smith, Ann C. M.

2006-01-01

442

History of Extension Work in Virginia Prior to Smith-Lever.  

ERIC Educational Resources Information Center

Before the Smith-Lever Act of 1914, agricultural schools begun in 11 Virginia congressional districts in 1908 performed a great deal of extension work, such as agricultural demonstrations, youth activities, and home economics programs. This helped pave the way for formal extension programs established by the legislation. (SK)

Hillison, John; Sutphin, Cathy M.

1999-01-01

443

Good Question! Statistical Ranking for Question Generation Michael Heilman Noah A. Smith  

E-print Network

Good Question! Statistical Ranking for Question Generation Michael Heilman Noah A. Smith Language,nasmith}@cs.cmu.edu Abstract We address the challenge of automatically generating questions from reading materials, we focus on question generation (QG) for the creation of educational materials for read- ing practice

Eskenazi, Maxine

444

Variation in hominoid molar enamel thickness Tanya M. Smith a,*, Anthony J. Olejniczak a  

E-print Network

Evolution 48 (2005) 575e592 #12;taxonomic discrimination using enamel thickness, tooth type and sectionVariation in hominoid molar enamel thickness Tanya M. Smith a,*, Anthony J. Olejniczak a , Lawrence.K. Received 25 August 2004; accepted 16 February 2005 Abstract Enamel thickness has figured prominently

Smith, Tanya M.

445

A terrestrial gamma ray flash observed from an aircraft D. M. Smith,1,2  

E-print Network

that a TGF of normal intensity would, at this distance, have produced a gamma ray signal in ADELE be possible for TGFs detected at closer range. Citation: Smith, D. M., et al. (2011), A terrestrial gamma ray- bilities of orbiting gamma ray detectors even from a distance of over 600 km away [Grefenstette et al

Cummer, Steven A.

446

Viewing Online Searching Within a Learning Paradigm Bernard J. Jansen, Brian Smith, Danielle L. Booth  

E-print Network

and Retrieval ­ Search process. General Terms Experimentation, Human Factors Keywords Information searchingViewing Online Searching Within a Learning Paradigm Bernard J. Jansen, Brian Smith, Danielle L investigate whether one can model online searching as a learning paradigm. We examined the searching

Jansen, James

447

Understanding Web Search via a Learning Paradigm Bernard J. Jansen, Brian Smith, Danielle L. Booth  

E-print Network

. General Terms Experimentation, Human Factors Keywords Information searching, Bloom's Taxonomy 1Understanding Web Search via a Learning Paradigm Bernard J. Jansen, Brian Smith, Danielle L. Booth view Web searching as a learning process, we examined the searching characteristics of 41 participants

Jansen, James

448

Discovery and antitumor activities of constituents from Cyrtomium fortumei (J.) Smith rhizomes  

PubMed Central

Background Cyrtomium fortumei (J.) Smith is an important Chinese herbal medicine because of its biological functions. However, systematic and comprehensive studies on the phytochemicals from Cyrtomium fortumei (J.) Smith and their bioactivity are limited. Results Using the bioassay-guided technique, the ethyl acetate and n-BuOH extracts of the rhizomes of Cyrtomium fortumei (J.) Smith were shown to exhibit good antitumor activities, consequently leading to the isolation of 23 compounds. All compounds were isolated from the plant for the first time. The inhibitory activities of these compounds were investigated on tumor cells MGC-803, PC3, and A375 in vitro by MTT (thiazolyl blue tetrazolium bromide) assay, and the results showed that pimpinellin (3) had potent cytotoxic activities against the three cell lines, with the IC50 values of 14.4?±?0.3??M, 20.4?±?0.5??M, and 29.2?±?0.6??M, respectively. The mechanism of the antitumor action indicated that pimpinellin inhibited the growth of MGC-803 cells via the induction of tumor cell apoptosis, with apoptosis ratio of 27.44% after 72?h of treatment at 20??M. Conclusions This study suggests that most of the compounds from the roots of Cyrtomium fortumei (J.) Smith could inhibit the growth of human carcinoma cells. Moreover, pimpinellin inhibited the growth of tumor cells via the induction of tumor cell apoptosis. PMID:23379693

2013-01-01

449

Problem Behaviors Associated with Deletion Prader-Willi, Smith-Magenis, and Cri Du Chat Syndromes.  

ERIC Educational Resources Information Center

Problem behaviors of 38 individuals with Cri-du-Chat syndrome, 55 individuals with Prader Willi syndrome, and 21 individuals with Smith-Magenis syndrome were investigated. All three disorders were Associated with greater ratings of problem behaviors (besides eating abnormalities and sleep abnormalities) than comparison groups. (Author/CR)

Clarke, David J.; Boer, Harm

1998-01-01

450

Sluggish and Brisk Ganglion Cells Detect Contrast With Similar Sensitivity Ying Xu, Narender K. Dhingra, Robert G. Smith, and Peter Sterling  

E-print Network

. Dhingra, Robert G. Smith, and Peter Sterling Department of Neuroscience, University of Pennsylvania, Narender K. Dhingra, Robert G. Smith, and Peter Sterling. Sluggish and brisk ganglion cells detect contrast the receptive field center when contrast is as low as 0.5% (Dhingra and Smith 2004; Dhingra et al. 2003

Smith, Robert G.

451

K. SHAFER SMITH AND ROSS TULLOCH Center for Atmosphere Ocean Science, Courant Institute of Mathematical Sciences, New York University, New York, New York  

E-print Network

Reply K. SHAFER SMITH AND ROSS TULLOCH Center for Atmosphere Ocean Science, Courant Institute). Tulloch and Smith (2006, 2009) argued that sur- face quasigeostrophic effects are consistent with many, Tulloch and Smith (2006) considered a ``toy'' model consisting of SQG flow overlying a finite-depth region

Smith, K. Shafer

452

The Adventures of Captain John Smith, Pocahontas and a Sundial: Cosmology, Mathematics, and Power at the Time of Jamestown  

NASA Astrophysics Data System (ADS)

While exploring the Chickahominy River in Virginia by canoe in December 1607, Captain John Smith was ambushed by 200 Powhatan Indians and chased into the swamp. Wounded by arrows and mired in the cold mud, Smith surrendered and was led to their chieftain, Opechancanough. Smith played for time. He pulled out his pocket sundial and proceeded to deliver a lecture on astronomy. The Indians marveled at the dancing needle of the magnetic compass, which they could plainly see but not touch because of the glass cover. They apparently thought less of his discourse in a foreign language on the sun, moon, and planets, as within the hour, Smith's captors had him tied to a tree and were ready to shoot him. But then, Opechancanough held the sundial aloft and spared Smith's life. For the next month, Smith was paraded around various Indian villages before being condemned to have his head bashed in. Pocahontas, however, threw herself across Smith's body in order to save his life. This legendary episode reveals more than Smith's ingenuity. His compass sundial, shaped and marked like a celestial globe, was a microcosm of his universe. It embodied the belief that the smallest things mirrored the large, that number was the key to God's creation, and that by means of mathematical instruments, men could dominate that world (or at least extricate themselves from tight spots!). This paper will examine the astronomical ideas and instruments on which these beliefs were based, and show how ultimately, Smith's sundial also represented the clash of two cosmologies-that of the Indians and European settlers.

Schechner, Sara J.

2007-12-01

453

Observation of copious emission at the fundamental frequency by a Smith-Purcell free-electron laser with sidewalls  

SciTech Connect

An experiment at microwave frequencies confirms the recent prediction that a Smith-Purcell [S. J. Smith and E. M. Purcell, Phys. Rev. 92, 1069 (1953)] free-electron laser equipped with sidewalls can emit radiation at the frequency of the surface wave. The power output is considerably greater than for the previously observed emission at the second harmonic, in agreement with three-dimensional simulations. The dependence of frequency on beam energy and emission angle is in good agreement with three-dimensional theory and simulations. Provided that a reduction in scale can be achieved, a path is open to coherent Smith-Purcell radiation at terahertz frequency.

Gardelle, J.; Modin, P. [CEA, CESTA, F-33114 Le Barp (France); Donohue, J. T. [Centre d'Etudes Nucleaires de Bordeaux-Gradignan, Universite Bordeaux 1, CNRS/IN2P3, BP 120, 33175 Gradignan (France)

2012-03-26

454

Update: Cutaneous leishmaniasis in U.S. military personnel--Southwest/Central Asia, 2002-2004.  

PubMed

Cutaneous leishmaniasis (CL) is a sand fly-borne parasitic infection. Preliminary data about cases of CL in military personnel deployed to three countries (Afghanistan, Iraq, and Kuwait) in Southwest/Central Asia have been published previously. During August 2002-February 2004, Department of Defense (DoD) staff identified 522 parasitologically confirmed cases of CL in military personnel. Leishmania major was the etiologic agent for all 176 cases for which species data, obtained by isoenzyme electrophoresis of cultured parasites, are available. This update focuses on the 361 cases (69% of 522) in patients whose demographic data were collected systematically under treatment protocols for therapy with the pentavalent antimonial compound sodium stibogluconate (Pentostam(R); GlaxoSmithKline, United Kingdom) at Walter Reed Army Medical Center, District of Columbia. U.S. health-care providers should consider CL in persons with persistent skin lesions who were deployed to Southwest/Central Asia or who were in other areas where leishmaniasis is endemic. PMID:15057192

2004-04-01

455

Clinical data on Fluarix: an inactivated split seasonal influenza vaccine.  

PubMed

Influenza viruses cause annual winter epidemics in temperate regions, with significant morbidity, mortality and economical impact. Fluarix is a split, trivalent, inactivated vaccine, manufactured from highly purified, egg-grown influenza viruses by GlaxoSmithKline. In 2005, Fluarix underwent accelerated approval for use in adults by the US FDA following a US-based, randomized, placebo-controlled trial that established its safety and immunogenicity in adults. The vaccine has been licensed in Europe since 1992 for all age groups. Multiple registration trials in all age groups in Europe have demonstrated that the vaccine was safe and well tolerated and of immunogenicity standards that met the requirements of the European Committee for Medicinal Products for Human Use. There are no published clinical trials evaluating the effectiveness or efficacy of Fluarix against influenza and its complications. Currently, Fluarix plays an important role in the diversification of the supply chain of influenza vaccine to the community. However, vaccines with improved immunogenicity in at-risk populations, such as the elderly, and with less reliance on growth in eggs, as well as the inherent demanding timelines, are needed to enhance the control of influenza. PMID:18665769

El Sahly, Hana M; Keitel, Wendy A

2008-08-01

456

Impact of rotavirus vaccination in Australian children below 5 years of age  

PubMed Central

This study was conducted to assess the impact of administration of two-dose rotavirus (RV) vaccine (RIX4414; GlaxoSmithKline Vaccines) among children aged less than 5 y in three states/territories of Australia. Aggregated and de-identified data on rotavirus gastroenteritis (RVGE) and all-cause gastroenteritis (AGE) from July 1998–June 2009 were obtained from the Australian Institute of Health and Welfare database. The baseline incidence (July 1998–June 2006) of RVGE hospitalizations before RV vaccine introduction in New South Wales (NSW), the Australian Capital Territory (ACT) and the Northern Territory (NT) were 33.75, 42.93 and 288.67 per 10?000 child-years, respectively among children aged 0–11 mo. Following RV vaccine introduction in NSW, the ACT and the NT, incidence of RVGE hospitalizations reduced to 13.06, 17.35 and 47.52 per 10?000 child-years, respectively, during July 2007–June 2008 and 3.87, 8.40 and 122.79 per 10,000 child-years, respectively, during July 2008–June 2009 among children aged 0–11 mo. Reductions in RVGE and AGE were also observed in all children below 5 y of age in NSW and the ACT. Overall reduction in hospitalizations due to RVGE and AGE was observed following RV vaccine introduction into the NIP in Australia. PMID:23733041

Pendleton, Annmarie; Galic, Maja; Clarke, Christopher; Ng, Su Peing; Ledesma, Emilio; Ramakrishnan, Gunasekaran; Liu, Yanfang

2013-01-01

457

Rational design of HIV vaccine and microbicides: report of the EUROPRISE annual conference  

PubMed Central

EUROPRISE is a Network of Excellence sponsored from 2007 to 2011 by the European Commission within the 6th Framework Program. The Network encompasses a wide portfolio of activities ranging from an integrated research program in the field of HIV vaccines and microbicides to training, dissemination and advocacy. The research program covers the whole pipeline of vaccine and microbicide development from discovery to early clinical trials. The Network is composed of 58 partners representing more than 65 institutions from 13 European countries; it also includes three major pharmaceutical companies (GlaxoSmithKline, Novartis and Sanofi-Pasteur) involved in HIV microbicide and vaccine research. The Network displays a dedicated and informative web page: http://www.europrise.org. Finally, a distinguishing trait of EUROPRISE is its PhD School of students from across Europe, a unique example in the world of science aimed at spreading excellence through training. EUROPRISE held its second annual conference in Budapest in November, 2009. The conference had 143 participants and their presentations covered aspects of vaccine and microbicide research, development and discovery. Since training is a major task of the Network, the students of the EUROPRISE PhD program summarized certain presentations and their view of the conference in this paper. PMID:20659333

2010-01-01

458

Evaluation of systemic and mucosal anti-HPV16 and anti-HPV18 antibody responses from vaccinated women.  

PubMed

Ideal methods to monitor HPV neutralizing antibodies induced by vaccination have not been established yet. Here, we evaluated systemic and cervical antibody levels induced by HPV16/18 AS04-adjuvanted vaccine (GlaxoSmithKline Biologicals) using a secreted alkaline phosphatase neutralization assay (SEAP-NA) and enzyme-linked immunosorbent assay (ELISA). Serum and cervical secretions from 50 vaccinated women were used to assess (1) overall assay reproducibility; (2) inter-assay and inter-specimen correlation; (3) correlations between month 1 and month 12 titers. Strong correlations between SEAP-NA and ELISA were observed (serum anti-HPV16/18, rho=0.91/0.85; cervix anti-HPV16/18, rho=0.84/0.89). Systemic and cervical antibody measures also correlated well (rho range: 0.64-0.75); except at mid-cycle (rho range: 0.28-0.65). Correlations between antibody levels at 1 and 12 months following the start of vaccination were poor (rho range: 0.16-0.38). In conclusion, HPV16/18 VLP-based ELISA is a reliable and valid method to monitor anti-HPV16/18 neutralizing potential for the first year following vaccination; however, additional studies will be required to better define the effects of the time on cycle and patterns of antibody response over time following vaccination. PMID:18541349

Kemp, Troy J; García-Piñeres, Alfonso; Falk, Roni T; Poncelet, Sylviane; Dessy, Francis; Giannini, Sandra L; Rodriguez, Ana Cecilia; Porras, Carolina; Herrero, Rolando; Hildesheim, Allan; Pinto, Ligia A

2008-07-01

459

Prophylactic human papillomavirus vaccines  

PubMed Central

Human papillomavirus (HPV) infection causes virtually all cases of cervical cancer, the second most common cause of death from cancer among women worldwide. This Review examines prophylactic HPV subunit vaccines based on the ability of the viral L1 capsid protein to form virus-like particles (VLPs) that induce high levels of neutralizing antibodies. Following preclinical research by laboratories in the nonprofit sector, Merck and GlaxoSmithKline are developing commercial versions of the vaccine. Both vaccines target HPV16 and HPV18, which account for approximately 70% of cervical cancer. The Merck vaccine also targets HPV6 and HPV11, which account for approximately 90% of external genital warts. The vaccines have an excellent safety profile, are highly immunogenic, and have conferred complete type-specific protection against persistent infection and associated lesions in fully vaccinated women. Unresolved issues include the most critical groups to vaccinate and when the vaccine’s cost may be low enough for widespread implementation in the developing world, where 80% of cervical cancer occurs. PMID:16670757

Lowy, Douglas R.; Schiller, John T.

2006-01-01

460

Keystone Symposium on Antibodies as Drugs  

PubMed Central

The symposium on Antibodies as Drugs, organized by Keystone Symposia and chaired by J. Marks, (University of California Los Angeles, USA), E.S. Ward (University of Texas Southwestern Medical Center, USA) and L. Weiner (Georgetown University Medical Center, USA), was held in Whistler, British Columbia. This Canadian Rockies village, which will host the 2010 Olympic Games, served as an enchanting backdrop to the meeting. The more than 350 speakers and attendees included scientists from major pharmaceutical firms, e.g., Abbott, MedImmune/Astra Zeneca, Bristol-Myers Squibb, Merck & Co., Pfizer, Sanofi-Aventis, Schering, GlaxoSmithKline, Eli Lilly, Hoffmann LaRoche, Novartis, Wyeth, and biotechnology companies, e.g., Ablynx, Medarex, Morphosys, GenMab, Amgen, Genentech, ImmunoGen, Agensys, Domantis, Biogen Idec, Centocor, LFB, Micromet, PDL Biopharma, Borean Pharma, Dyax Corp., Symphogen and Syntonix. Academic research groups at Imperial College London, University of Oxford, ETH Zürich, Scripps, Institute Cochin, Karolinska Institute, Utrecht University, Harvard Medical School, Massachusetts Institute of Technology, Baylor College, Paul Ehrlich Institute, University of California San Francisco, University of California San Diego, University of Nantes, University of Tours and Ludwig Institute were also represented, as were regulatory authorities, including the US Food and Drug Administration, National Institutes of Health and the Public Health Agency of Canada). The meeting was very interactive and included thoughtful exchanges during the different sessions and networking events. PMID:20068403

Larbouret, Christel; Robert, Bruno

2009-01-01

461

Identification and Characterization of Hundreds of Potent and Selective Inhibitors of Trypanosoma brucei Growth from a Kinase-Targeted Library Screening Campaign  

PubMed Central

In the interest of identification of new kinase-targeting chemotypes for target and pathway analysis and drug discovery in Trypanosomal brucei, a high-throughput screen of 42,444 focused inhibitors from the GlaxoSmithKline screening collection was performed against parasite cell cultures and counter-screened against human hepatocarcinoma (HepG2) cells. In this way, we have identified 797 sub-micromolar inhibitors of T. brucei growth that are at least 100-fold selective over HepG2 cells. Importantly, 242 of these hit compounds acted rapidly in inhibiting cellular growth, 137 showed rapid cidality. A variety of in silico and in vitro physicochemical and drug metabolism properties were assessed, and human kinase selectivity data were obtained, and, based on these data, we prioritized three compounds for pharmacokinetic assessment and demonstrated parasitological cure of a murine bloodstream infection of T. brucei rhodesiense with one of these compounds (NEU-1053). This work represents a successful implementation of a unique industrial-academic collaboration model aimed at identification of high quality inhibitors that will provide the parasitology community with chemical matter that can be utilized to develop kinase-targeting tool compounds. Furthermore these results are expected to provide rich starting points for discovery of kinase-targeting tool compounds for T. brucei, and new HAT therapeutics discovery programs. PMID:25340575

Diaz, Rosario; Luengo-Arratta, Sandra A.; Seixas, Joao D.; Amata, Emanuele; Devine, William; Cordon-Obras, Carlos; Rojas-Barros, Domingo I.; Jimenez, Elena; Ortega, Fatima; Crouch, Sabrinia; Colmenarejo, Gonzalo; Fiandor, Jose Maria; Martin, Jose Julio; Berlanga, Manuela; Gonzalez, Silvia; Manzano, Pilar; Navarro, Miguel; Pollastri, Michael P.

2014-01-01

462

The Cost-Effectiveness of Rotavirus Vaccination in Malawi  

PubMed Central

Background. Rotarix (GlaxoSmithKline), a newly licensed rotavirus vaccine requiring 2 doses, may have the potential to save hundreds of thousands of lives in Africa. Nations such as Malawi, where Rotarix is currently under phase III investigation, may nevertheless face difficult economic choices in considering vaccine adoption. Methods. The cost-effectiveness of implementing a Rotarix vaccine program in Malawi was estimated using published estimates of rotavirus burden, vaccine efficacy, and health care utilization and costs. Results. With 49.5% vaccine efficacy, a Rotarix program could avert 2582 deaths annually. With GAVI Alliance cofinancing, adoption of Rotarix would be associated with a cost of $5.07 per disability-adjusted life-year averted. With market pricing, Rotarix would be associated with a base case cost of $74.73 per disability-adjusted life-year averted. Key variables influencing results were vaccine efficacy, under-2 rotavirus mortality, and program cost of administering each dose. Conclusions. Adopting Rotarix would likely be highly cost-effective for Malawi, particularly with GAVI support. This finding holds true across uncertainty ranges for key variables, including efficacy, for which data are becoming available. PMID:20684689

Berry, Stephen A.; Johns, Benjamin; Shih, Chuck; Berry, Andrea A.; Walker, Damian G.

2010-01-01

463

Bioequivalence study of 8?mg ondansetron film-coated tablets in healthy Caucasian volunteers.  

PubMed

The aim of the study was to investigate the bioequivalence of a generic product of 8?mg film-coated tablets (test) to the branded product (reference) at the same strength in order to apply for regulatory approval. The secondary objective of the study was to compare the tolerability of both products. A double blinded, randomized, cross-over, 2-period, comparative study was conducted in healthy Caucasian volunteers under fasting conditions. A single oral dose administration of the test or reference product was followed by a 7-day wash-out period. The ondansetron concentration was determined using a validated high performance liquid chromatography with a UV detection method. The 90% confidence interval of the point estimate (test over reference products) for C(max) and AUC(0-t) fell within the 80.00-125.00% acceptance range. The results of the study indicate that the film-coated tablets of Ondatron 8?mg manufactured by Tarchomi?skie Zak?ady Farmaceutyczne Polfa S.A. (test product) are bioequivalent to those of Zofran manufactured by GlaxoSmithKline Export Ltd (reference product). Both products were well tolerated. PMID:24132707

Rudzki, P J; Kaza, M; Le?, A; Gilant, E; Ksyci?ska, H; Serafin-Byczak, K; Tro?, M; Raszek, J; Pi?tkowska-Chabuda, E; Skowro?ska-Smolak, M; Tarasiuk, A; Wilkowska, E; ?azowski, T

2014-04-01

464

Assessment of acceptability and ease of use of atovaquone/proguanil medication in subjects undergoing malaria prophylaxis  

PubMed Central

Objective: International travelers from non-endemic areas are at high risk of contracting malaria due to their lack of immunity. Prevention is therefore of outmost importance and is achieved through effective and safe chemoprophylaxis, which reduces the risk of fatal disease. Among the various antimalarial drugs available, the synergistic combination of atovaquone and proguanil (A/P) (Malarone®; Glaxo-SmithKline) has proven a valuable option in terms of effective protection against chloroquine and multi-drug resistant falciparum malaria, safety, tolerability, and ease of use, thus favoring compliance. The purpose of the present study was to assess acceptability and ease of use of A/P chemoprophylaxis in a population of employees of the oil industry bound to malarious areas. Particular attention was paid to treatment adherence. Methods: A survey was conducted on a sample of 700 employees on A/P chemoprophylaxis. Demographic data and specific information on A/P treatment were collected by means of a 16-item questionnaire administered immediately before departure. All questionnaires returned were then entered into a database and statistically analyzed. Results: Both habitual and first-time travelers showed good adherence to A/P chemoprophylactic regimen. In general, only few adverse side-effects were reported, none of which were serious. Travelers with previous experience of other antimalarials stated A/P prophylaxis had proven advantageous due to fewer adverse reactions, better condition of administration, and better sense of protection compared with other available treatments. PMID:19209290

Nicosia, V; Colombo, Giorgio; Consentino, M; Di Matteo, S; Mika, F; De Sanctis, S; Ratti, S; Vinci, Marta

2008-01-01

465

Licensure of a Haemophilus influenzae type b (Hib) vaccine (Hiberix) and updated recommendations for use of Hib vaccine.  

PubMed

On August 19, 2009, the Food and Drug Administration (FDA) licensed Hiberix (GlaxoSmithKline Biologicals, Rixensart, Belgium), a Haemophilus influenzae type b (Hib) conjugate vaccine composed of H. influenzae type b capsular polysaccharide (polyribosyl-ribitol-phosphate [PRP]) conjugated to inactivated tetanus toxoid (PRP-T). Hiberix is licensed for use as the booster (final) dose of the Hib vaccine series for children aged 15 months through 4 years (before the 5th birthday) who have received previously the primary series of Hib vaccination (consisting of 2 or 3 doses, depending on the formulation). The Advisory Committee on Immunization Practices (ACIP) recommends Hib booster vaccination for children at ages 12 through 15 months; however, because of the recent shortage of Hib vaccines, many children have deferred the booster dose and therefore require catch-up vaccination. This report summarizes the indications for Hiberix use and provides guidance on Hib booster dose administration based on increasing vaccine supplies. Vaccination recommendations in this report update the previous advisory on Hib booster administration (June 26, 2009), which advised that children with deferred booster doses receive it at the next regularly scheduled visit. Vaccination providers are now recommended to begin recall of children in need of the booster dose when feasible and monovalent Hib vaccine supply in the office is adequate. PMID:19763078

2009-09-18

466

Species- and dose-specific pancreatic responses and progression in single- and repeat-dose studies with GI181771X: a novel cholecystokinin 1 receptor agonist in mice, rats, and monkeys.  

PubMed

Compound-induced pancreatic injury is a serious liability in preclinical toxicity studies. However, its relevance to humans should be cautiously evaluated because of interspecies variations. To highlight such variations, we evaluated the species- and dose-specific pancreatic responses and progression caused by GI181771X, a novel cholecystokinin 1 receptor agonist investigated by GlaxoSmithKline for the treatment of obesity. Acute (up to 2,000 mg/kg GI181771X, as single dose) and repeat-dose studies in mice and/or rats (0.25-250 mg/kg/day for 7 days to 26 weeks) showed wide-ranging morphological changes in the pancreas that were dose and duration dependent, including necrotizing pancreatitis, acinar cell hypertrophy/atrophy, zymogen degranulation, focal acinar cell hyperplasia, and interstitial inflammation. In contrast to rodents, pancreatic changes were not observed in cynomolgus monkeys given GI181771X (1-500 mg/kg/day with higher systemic exposure than rats) for up to 52 weeks. Similarly, no GI181771X treatment-associated abnormalities in pancreatic structure were noted in a 24-week clinical trial with obese patients (body mass index >30 or >27 kg/m(2)) as assessed by abdominal ultrasound or by magnetic resonance imaging. Mechanisms for interspecies variations in the pancreatic response to CCK among rodents, monkeys, and humans and their relevance to human risk are discussed. PMID:24178573

Myer, James R; Romach, Elizabeth H; Elangbam, Chandikumar S

2014-01-01

467

Discovery of next generation inhibitors of HIV protease.  

PubMed

Due to factors such as resistance and long-term side effects as well as dosing regimen-related adherence issues, HIV therapy is a constantly moving target. HIV-1 protease inhibitors had an immediate and dramatic impact on the outcome of HIV/AIDS when launched in late 1995, and the search for new and improved next generation molecules has been under way in many laboratories. At GlaxoSmithKline (GSK) and Vertex Pharmaceuticals, this effort focused on two key issues, patient compliance and viral resistance. Using a water-solubilizing prodrug approach, the pill-burden in delivering our protease inhibitor, amprenavir, was dramatically decreased. By eliminating the large amounts of excipients necessary for the original soft-gel formulation, fosamprenavir (Lexiva/Telzir) delivers the clinically efficacious dose of amprenavir with two compact tablets per dose, compared to eight gel capsules. Our efforts to overcome viral resistance to 1(st) generation protease inhibitors by further elaborating the SAR of the amprenavir and related scaffolds, led to successive and dramatic improvements in wild-type antiviral potencies, and ultimately to the discovery of "ultra-potent" molecules with very favorable overall resistance profiles. The selection of GW640385 (brecanvir--USAN approved only) as a clinical candidate and its progression into current phase 2 dose ranging studies represents the culmination of our effort toward next generation protease inhibitors. PMID:16375744

Spaltenstein, Andrew; Kazmierski, Wieslaw M; Miller, John F; Samano, Vicente

2005-01-01

468

New World Cutaneous Leishmaniasis Treated with Intralesional Injection of Pentavalent Antimony  

PubMed Central

Cutaneous leishmaniasis is a skin infection caused by the Leishmania species, an intracellular protozoan parasite that is transmitted by various species of female sandflies. According to the geographic distribution and vectors, leishmaniasis is classified as Old World or New World cutaneous leishmaniasis. In Korea, 24 cases of Old World cutaneous leishmaniasis have been reported, but New World cutaneous leishmaniasis has not been reported as yet. A 37-year-old man presented with a 3-month history of a painful and erythematous nodule with two satellite papules on the left postauricular area and a papule on the left arm after traveling to the Amazon region in Brazil. After we performed skin biopsies of the lesions, diagnosis of cutaneous leishmaniasis was made by the histopathological findings. After intralesional injection of sodium stibogluconate (Pentostam®, GlaxoSmithKline) twice a week for 4 weeks, the lesions improved with scarring. Herein, we discuss this case of New World cutaneous leishmaniasis that was successfully treated with intralesional injection of sodium stibogluconate (Pentostam®) in Korea. PMID:23467266

Shin, Ji Yeon; Lee, Young Bok; Cho, Baik Kee

2013-01-01

469

Comparison of ELISpot and FluoroSpot in the Analysis of Swine Flu-Specific IgG and IgA Secretion by in Vivo Activated Human B Cells  

PubMed Central

We have evaluated a novel B-cell FluoroSpot assay for the analysis of antibody responses in healthy individuals vaccinated intramuscularly with Influenza A (H1N1) antigen (Pandemrix®, GlaxoSmithKline). Using the FluoroSpot assay and an ELISpot assay run in parallel for comparison, we measured the frequency of cells secreting antigen-specific as well as total IgG or IgA antibodies seven days post vaccination. The assays were based on high affinity monoclonal antibodies for capture and detection of human IgG and IgA. Whereas conventional ELISpot analyzes IgG- and IgA-secreting B cells separately, fluorescent detection enabled simultaneous enumeration of B cells secreting IgG or IgA in the same well. The FluoroSpot protocol was also simpler as the assay could be performed without the need for an amplifying detection step. While having all the advantages of a conventional ELISpot assay, including high sensitivity, robustness and ease of performance, the FluoroSpot assay adds further value in reducing costs, time and material. PMID:24710411

Kesa, Gun; Larsson, Per H.; Ahlborg, Niklas; Axelsson, Bernt

2012-01-01

470

Use of MenACWY-CRM vaccine in children aged 2 through 23 months at increased risk for meningococcal disease: recommendations of the Advisory Committee on Immunization Practices, 2013.  

PubMed

During its October 2013 meeting, the Advisory Committee on Immunization Practices (ACIP) recommended use of a third meningococcal conjugate vaccine, MenACWY-CRM (Menveo, Novartis), as an additional option for vaccinating infants aged 2 through 23 months at increased risk for meningococcal disease. MenACWY-CRM is the first quadrivalent meningococcal conjugate vaccine licensed for use in children aged 2 through 8 months. MenACWY-D (Menactra, Sanofi Pasteur) is recommended for use in children aged 9 through 23 months who are at increased risk for meningococcal disease, and Hib-MenCY-TT (MenHibrix, GlaxoSmithKline) is recommended for use in children aged 6 weeks through 18 months at increased risk. This report summarizes information on MenACWY-CRM administration in infants and provides recommendations for vaccine use in infants aged 2 through 23 months who are at increased risk for meningococcal disease. Because the burden of meningococcal disease in infants is low in the United States and the majority of cases that do occur are caused by serogroup B, which is not included in any vaccine licensed in the United States, only those infants who are at increased risk for meningococcal disease are recommended to receive a meningococcal vaccine. PMID:24941332

MacNeil, Jessica R; Rubin, Lorry; McNamara, Lucy; Briere, Elizabeth C; Clark, Thomas A; Cohn, Amanda C

2014-06-20

471

Induction of Bordetella pertussis-specific immune memory by DTPa vaccines.  

PubMed

Several vaccines are available against pertussis, differing by the number of Bordetella pertussis antigens that they contain as well as their formulation. The GlaxoSmithKline Biologicals (GSK Bio) tricomponent DTPa vaccine (DTPa3, Infanrix™), and the Sanofi-Pasteur (SP) five-component formulation (DTPa5, Pediacel™) were shown to have comparable short-term efficacy in clinical trials. However, potential differences in long-term protection were recently suggested, which might reflect the elicitation of different specific immune memory by the two vaccines. Therefore, the purpose of the present study was to investigate in mice the immune responses against B. pertussis, and particularly the establishment of specific B cell memory after immunization with DTPa3 and DTPa5 vaccines. Whereas intranasal challenge experiments showed similar protection with both vaccines, DTPa3 induced higher antibody levels to FHA and PRN than DTPa5. Further, the frequency of memory B cells was investigated by B cell ELISPOT. Higher frequencies of PT- and PRN-specific memory B cells were evidenced after vaccination with DTPa3, compared with DTPa5. Although the origin of such difference is unclear, the use of two different adjuvants (aluminum phosphate versus hydroxide) is proposed as a possible explanation. In conclusion, this study proposes that the induction of higher levels of B. pertussis antigen-specific memory B cells with DTPa3 participate to the suggested longer persistence of protection observed with this vaccine, as compared with DTPa5. PMID:21382483

Morel, Sandra; Denoël, Philippe; Godfroid, Fabrice; Cortvrindt, Caroline; Vanderheyde, Nathalie; Poolman, Jan

2011-04-18

472

Molecular analysis of varicella vaccines and varicella-zoster virus from vaccine-related skin lesions.  

PubMed

To prevent complications that might follow an infection with varicella-zoster virus (VZV), the live attenuated Oka strain (V-Oka) is administered to children in many developed countries. Three vaccine brands (Varivax from Sanofi Pasteur MSD; Varilrix and Priorix-Tetra, both from Glaxo-Smith-Kline) are licensed in Germany and have been associated with both different degrees of vaccine effectiveness and adverse effects. To identify genetic variants in the vaccines that might contribute to rash-associated syndromes, single nucleotide polymorphism (SNP) profiles of variants from the three vaccines and rash-associated vaccine-type VZV from German vaccinees were quantitatively compared by PCR-based pyrosequencing (PSQ). The Varivax vaccine contained an estimated 3-fold higher diversity of VZV variants, with 20% more wild-type (wt) SNPs than Varilrix and Priorix-Tetra. These minor VZV variants in the vaccines were identified by analyzing cloned full-length open reading frame (ORF) orf62 sequences by chain termination sequencing and PSQ. Some of these sequences amplified from vaccine VZV were very similar or identical to those of the rash-associated vaccine-type VZV from vaccinees and were almost exclusively detected in Varivax. Therefore, minorities of rash-associated VZV variants are present in varicella vaccine formulations, and it can be concluded that the analysis of a core set of four SNPs is required as a minimum for a firm diagnostic differentiation of vaccine-type VZV from wt VZV. PMID:21562115

Thiele, Sonja; Borschewski, Aljona; Küchler, Judit; Bieberbach, Marc; Voigt, Sebastian; Ehlers, Bernhard

2011-07-01

473

Estimated research and development costs of rotavirus vaccines.  

PubMed

Diseases like rotavirus afflict both upper- and lower-income countries, but most serious illnesses and deaths occur among the latter. It is a vital public health issue that vaccines for these types of global diseases can recover research and development (R&D) costs from high-priced markets quickly so that manufacturers can offer affordable prices to lower-income nations. Cost recovery depends on how high R&D costs are, and this study attempts to replace high, unverified estimates with lower, more verifiable estimates for two new vaccines, RotaTeq (Merck) and Rotarix (GlaxoSmithKline or GSK), based on detailed searches of public information and follow-up interviews with senior informants. We also offer a new perspective on "cost of capital" as a claim for recovery from public bodies. Our estimates suggest that companies can recover all fixed costs quickly from affluent markets and thus can offer these vaccines to lower-income countries at prices they can afford. Better vaccines are a shared project between companies and public health agencies; greater transparency and consistency in reporting of R&D costs is needed so that fair prices can be established. PMID:19665605

Light, Donald W; Andrus, Jon Kim; Warburton, Rebecca N

2009-11-01

474

A practical derivatization LC/MS approach for determination of trace level alkyl sulfonates and dialkyl sulfates genotoxic impurities in drug substances.  

PubMed

Derivatization LC/MS methodology has been developed for the determination of a group of commonly encountered alkyl esters of sulfonates or sulfates in drug substances at low ppm levels. This general method uses trimethylamine as the derivatizing reagent for ethyl/propyl/isopropyl esters and triethylamine for methyl esters. The resulting quaternary ammonium derivatization products are highly polar (ionic) and can be retained by a hydrophilic interaction liquid chromatography (HILIC) column and readily separated from the main interfering active pharmaceutical ingredient (API) peak that is usually present at very high concentration. The method gives excellent sensitivity for all the alkyl esters at typical target analyte level of 1-2 ppm when the API samples were prepared at 5mg/mL. The recoveries at 1-2 ppm were generally above 85% for all the alkyl esters in the various APIs tested. The injection precisions of the lowest concentration standards were excellent with R.S.D.=0.4-4%. A linear range for concentrations from 0.2 to 20 ppm has been established with R(2)>or=0.99. This general method has been tested in a number of API matrices and used successfully for determination of alkyl sulfonates or dialkyl sulfates in support of API batch releases at GlaxoSmithKline. PMID:18687555

An, Jianguo; Sun, Mingjiang; Bai, Lin; Chen, Ted; Liu, David Q; Kord, Alireza

2008-11-01

475

Analysis of augmented aircraft flying qualities through application of the Neal-Smith criterion  

NASA Technical Reports Server (NTRS)

The Neal-Smith criterion is examined for possible applications in the evaluation of augmented fighter aircraft flying qualities. Longitudinal and lateral flying qualities are addressed. Based on the application of several longitudinal flying qualities data bases, revisions are proposed to the original criterion. Examples are given which show the revised criterion to be a good discriminator of pitch flying qualities. Initial results of lateral flying qualities evaluation through application of the Neal-Smith criterion are poor. Lateral aircraft configurations whose flying qualities are degraded by roll ratcheting effects map into the Level 1 region of the criterion. A third dimension of the criterion for flying qualities specification is evident. Additional criteria are proposed to incorporate this dimension into the criterion structure for flying qualities analysis.

Bailey, R. E.; Smith, R. E.

1981-01-01

476

Smith Institute: New and Emerging Themes in Industrial and Applied Mathematics (NETIAM)  

NSDL National Science Digital Library

New and Emerging Themes in Industrial and Applied Mathematics (NETIAM) is a project of the Smith Institute and supported by the European Commission's programme in New and Emerging Science and Technology (NEST). Starting in March 2004 and lasting for 15 months, the project brings together researchers from the Smith Institute, Fraunhofer-ITWM in Germany, the Technical University of Eindhoven in The Netherlands, the University of Firenze in Italy and Ventspils University College in Latvia. Using mathematical frameworks, they will identify ground-breaking research directions in four themes: modelling the business environment; modelling criminality in the social environment; visualization and simulation of materials; and complexity at the molecular level. Thematic Workshops "will exploit the brainstorming capabilities of the participants in a facilitated think-tank environment" and a final plenary workshop will report the results of their work. The website provides additional information on the project and invites researchers to join in the Thematic Workshops.

2006-01-06

477

[Smith-Lemli-Opitz syndrome and hypothyroidism: the first Venezuelan case].  

PubMed

The Smith-Lemli-Opitz syndrome (SLOS) is an autosomal recessive metabolic disorder due to an abnormal cholesterol synthesis. It was first described by Smith, Lemli and Opitz in 1964. Many cases of SLOS have been described since then, leading to the recognition as a relatively common malformation syndrome. Affected individuals have dysmorphism, microcephaly, multiple congenital malformations, mental retardation, aggressiveness and hyperactivity. The severity of physical defects correlates with the severity of the cholesterol deficiency, which is caused by an abnormally low activity of 7-dehydrocholesterol reductase, the enzyme responsible for conversion of 7-dehydrocholesterol to cholesterol. The occurrence of hypothyroidism in association with SLOS is very unusual. We describe the first Venezuelan case in which both anomalies are associated. PMID:25272525

Lima-Martínez, Marcos M; Zerpa, José; Gil, Victor

2014-09-01

478

computational infrastructure for nuclear astrophysics Michael Smith, Physics Division, Oak Ridge Na:onal Lab coordinator@nucastrodata.org  

E-print Network

computational infrastructure for nuclear astrophysics Michael Smith, Physics Division, Oak Ridge Na:onal Lab coordinator@nucastrodata.org #12;computational infrastructure for nuclear astrophysics system overview ·work with nuclear information, reaction rates, & simulations ·operates "in

479

Evolving an Agent-Based Model to Probe Behavioral Rules in Flocks of Cowbirds V. Anne Smith1  

E-print Network

.smith@st-andrews.ac.uk Abstract Flocks of brown-headed cowbirds, Molothrus ater, self- organize social environments, which have of brown-headed cowbirds, Molothrus ater. The brown-headed cowbird is an obligate brood parasite: females

Smith, V Anne

480

76 FR 55413 - Proposed Safe Harbor Agreement for California Red-legged Frog, California Tiger Salamander, Smith...  

Federal Register 2010, 2011, 2012, 2013

...Harbor Agreement for California Red-legged Frog, California Tiger Salamander, Smith's...federally threatened California red-legged frog (Rana draytonii) and California tiger...conservation of the California red-legged frog, California tiger salamander,...

2011-09-07

481

PROPEL: An Approach Supporting Property Elucidation Rachel L. Smith, George S. Avrunin, Lori A. Clarke, and Leon J. Osterweil  

E-print Network

1 PROPEL: An Approach Supporting Property Elucidation Rachel L. Smith, George S. Avrunin, Lori A, details that need to be considered. PROPEL aims to make the job of writing and understanding properties

Massachusetts at Amherst, University of

482

78 FR 66748 - Smith Miller and Patch Inc. et al.; Proposal to Withdraw Approval of 14 New Drug Applications...  

Federal Register 2010, 2011, 2012, 2013

...NDA 004979.................. Multi-Vitamin Smith Miller and Tablets. Patch Inc., P.O. Box 367...Methischol (inositol/ USV Pharmaceutical vitamin B12/ Corp., 500 Virginia racemethionine/ Dr., Fort...

2013-11-06

483

Cholinesterase activities as potential biomarkers : characterization in two freshwater1 snails, Potamopyrgus antipodarum (Mollusca, Hydrobiidae, Smith 1889) and Valvata2  

E-print Network

, Potamopyrgus antipodarum (Mollusca, Hydrobiidae, Smith 1889) and Valvata2 piscinalis (Mollusca, Valvatidae, M gastropod mollusks, Potamopyrgus antipodarum and27 Valvata piscinalis, in order to ascertain their value pesticide contamination.40 41 Keywords42 Cholinesterase activity; substrates; Potamopyrgus antipodarum

Paris-Sud XI, Université de

484

Diagenetic history and evolution of porosity of the Cotton Valley Limestone, Southeastern Smith County, Texas  

E-print Network

wells studied are from the upper 200 ft (61 m) of the Cotton Valley Limestone in southeastern Smith County, Texas (Figure 8). The lithologies of these rocks range from grainy, non-skeletal lime- stones to less grainy, non-skeletal and skeletal... limestones to muddy limestones with shaly intervals. These lithic types can be divided further on the basis of composition, texture, and sedimentary struc- tures (Figures 9-17). Composition Cotton Valley constituent grains consist mainly of non-skeletal...

Covington, Thomas Edward

2012-06-07

485

An efficient and high performance linear recursive variable expansion implementation of the Smith-Waterman algorithm.  

PubMed

In this paper, we present an efficient and high performance linear recursive variable expansion (RVE) implementation of the Smith-Waterman (S-W) algorithm and compare it with a traditional linear systolic array implementation. The results demonstrate that the linear RVE implementation performs up to 2.33 times better than the traditional linear systolic array implementation, at the cost of utilizing 2 times more resources. PMID:19963596

Hasan, Laiq; Al-Ars, Zaid

2009-01-01

486

Additional dates of Sir Andrew Smith's Illustrations of the Zoology of South Africa.  

PubMed

We update the collation of the dates of publication of Smith's Illustrations of the Zoology of South Africa provided by Waterhouse (1880) and Barnard (1950, 1952). In the case of nine parts, we are able to provide more accurate dates of publication (including day-dates for seven of these parts). For workers of invertebrate taxonomy, we provide an accurate date of publication for W. S. Macleay's volume on Annulosa.  PMID:24870491

Low, Martyn E Y; Evenhuis, Neal L

2014-01-01

487

Moderator: Dr JR AllingtonSmith # Title Examiner Moderator Time Date Location  

E-print Network

A 50b SUSY signals at the LHC Krauss Richardson AllingtonSmith 11:00 02May PH251 Supervisors, 11.00 a.m. A.M Clarke Terry Halliday Wednesday, 1st May, 10.00 a.m. S.D Cunningham Hampshire Initials # Day Time Allen J M 50a Dr Krauss Prof Richardson Prof Clark Wed 11:00 Barrett T D 73 Prof Hughes

Wirosoetisno, Djoko

488

Modelling the biological variance of the yellow aspect of Granny smith apple colour  

Microsoft Academic Search

BACKGROUND: The yellow aspect of colour is usually not considered for produce with a green-to-red or a green-to-yellow transition upon ripening. The magnitude of change is simply too small and, additionally, masked by a large variation. The colour of Granny Smith apples, harvested from three orchards at two stages of maturity, was measured individually using the CIE L*a*b* system during

L. M. M. Tijskens; Rob E Schouten; Pawel J Konopacki; Janez Hribar; M. Simcic

2010-01-01

489

Math 320 (Smith): Practice Exam 1 1. (16 points -10 min.) For  

E-print Network

Math 320 (Smith): Practice Exam 1 1. (16 points - 10 min.) For dy dt = (ey+2 - 1)(ey - 1)(y - 2), y, t . 2. (21 points - 15-20 min.) Solve (15 points) y - y3 x exp(x2 ) = 0 (2) for y(0) = -2. Give the range of validity of the solution (6 points). 3. (24 points - 15-20 min) Write the following systems

Sheridan, Jennifer

490

Energy conservation study on Smith Frozen Foods processing plant, Weston, Oregon  

SciTech Connect

A comprehensive energy study was performed at Smith Frozen Foods in Weston, Oregon, in the fall of 1984. The plant processes corn, peas, lima beans and carrots. The products are inspected, prepared and graded before being sent through freeze tunnels. The frozen products are dumped into tote bins which are transported into cold storage warehouses. Energy conservation measures were calculated using a modified return on investment analysis called a return on capital (ROC) analysis and current rate schedules.

Not Available

1985-01-02

491

Estimation of Smith-Purcell radiation in laser-plasmas interaction  

Microsoft Academic Search

We present an estimation of Smith-Purcell Radiation by electrons generated in laser-plasmas interaction, passing near a metallic grating surface. The radiation wavelengths change with different grating periods and emission angles. The output photon numbers are also estimated. This effect could be developed into a new kind of tuneable table-top radiation source and also a diagnostics for the electron transport in

Z. Jin; Z. L. Chen; R. Kodama

2008-01-01

492

Robustness of the Smith predictor with respect to uncertainty in the time-delay parameter  

Microsoft Academic Search

The robust stability of the Smith predictor scheme for time-delay compensation is analyzed with respect to uncertainty in the time-delay parameter. Appropriate definitions are introduced for the phase margin and complementary phase margin of nonminimum-phase systems, and are used to characterize the domains of stability for the closed loop using a Nyquist approach. Rigorous arguments are used to show that

E. J. Adam; H. A. Latchman; O. D. Crisalle

2000-01-01

493

A modified Smith predictor for controlling a process with an integrator and long dead-time  

Microsoft Academic Search

A modification of the Smith predictor for controlling higher-order processes with integral action and long dead-time is proposed. The controller has a quite simple structure which is obtained based on the model consisting of an ideal integrator and dead-time and which includes only three tuning parameters: the dead-time, velocity gain of the model, and the desired time constant of the

M. R. Matausek; Aleksandar D. Micic

1996-01-01

494

A modified Smith predictor and controller for unstable processes with time delay  

Microsoft Academic Search

An integrated design procedure is developed for a modified Smith predictor and associated controller for linear time-delay systems having transfer functions of the form k1, A exp (—sT)\\/B, where A and B are monic polynomials in s of degree n — l and n, respectively. A is Hurwitz and B has a single right-half-plane root at s = ?. For

ANNRAOI M. DE PAOR

1985-01-01

495

Robust control of time-delay systems using the Smith predictor  

Microsoft Academic Search

In this paper we study the robust performance of time-delay systems using the structured singular value (?). By employing the properties of the Smith predictor, we are able to convert it to a delay-free problem. This not only simplifies the analysis and design but also avoids the problem of the rational time-delay approximation, which is usually needed. A SISO design

ZI-QIN WANG; SIGURD SKOGESTAD

1993-01-01

496

A review of "The Cambridge Companion to Newton." by I. Bernard Cohen & George E. Smith, eds.  

E-print Network

REVIEWS 135 were subject, the ways rulers influenced medicine, and how royal practitioners shaped and reacted to changing political fortunes. I. Bernard Cohen & George E. Smith, eds. The Cambridge Compan- ion to Newton. Cambridge: Cambridge... University Press, 2002. xiv + 514pp. ?15.95 paper/? 45.00 hard. Review BY ALESSANDRO GIOSTRA, ACCADEMIA GEORGICA, TREIA. ?The goal of this volume is to provide an introduction to Newton?s work, enabling readers to gain more rapid access...

Alessandro Giostra

2003-01-01

497

Acceleration of the Smith-Waterman algorithm using single and multiple graphics processors  

NASA Astrophysics Data System (ADS)

Finding regions of similarity between two very long data streams is a computationally intensive problem referred to as sequence alignment. Alignment algorithms must allow for imperfect sequence matching with different starting locations and some gaps and errors between the two data sequences. Perhaps the most well known application of sequence matching is the testing of DNA or protein sequences against genome databases. The Smith-Waterman algorithm is a method for precisely characterizing how well two sequences can be aligned and for determining the optimal alignment of those two sequences. Like many applications in computational science, the Smith-Waterman algorithm is constrained by the memory access speed and can be accelerated significantly by using graphics processors (GPUs) as the compute engine. In this work we show that effective use of the GPU requires a novel reformulation of the Smith-Waterman algorithm. The performance of this new version of the algorithm is demonstrated using the SSCA#1 (Bioinformatics) benchmark running on one GPU and on up to four GPUs executing in parallel. The results indicate that for large problems a single GPU is up to 45 times faster than a CPU for this application, and the parallel implementation shows linear speed up on up to 4 GPUs.

Khajeh-Saeed, Ali; Poole, Stephen; Blair Perot, J.

2010-06-01

498

Smith-Lemli-Opitz syndrome is caused by mutations in the 7-dehydrocholesterol reductase gene.  

PubMed Central

Smith-Lemli-Opitz syndrome is a frequently occurring autosomal recessive developmental disorder characterized by facial dysmorphisms, mental retardation, and multiple congenital anomalies. Biochemically, the disorder is caused by deficient activity of 7-dehydrocholesterol reductase, which catalyzes the final step in the cholesterol-biosynthesis pathway-that is, the reduction of the Delta7 double bond of 7-dehydrocholesterol to produce cholesterol. We identified a partial transcript coding for human 7-dehydrocholesterol reductase by searching the database of expressed sequence tags with the amino acid sequence for the Arabidopsis thaliana sterol Delta7-reductase and isolated the remaining 5' sequence by the "rapid amplification of cDNA ends" method, or 5'-RACE. The cDNA has an open reading frame of 1,425 bp coding for a polypeptide of 475 amino acids with a calculated molecular weight of 54.5 kD. Heterologous expression of the cDNA in the yeast Saccharomyces cerevisiae confirmed that it codes for 7-dehydrocholesterol reductase. Chromosomal mapping experiments localized the gene to chromosome 11q13. Sequence analysis of fibroblast 7-dehydrocholesterol reductase cDNA from three patients with Smith-Lemli-Opitz syndrome revealed distinct mutations, including a 134-bp insertion and three different point mutations, each of which was heterozygous in cDNA from the respective parents. Our data demonstrate that Smith-Lemli-Opitz syndrome is caused by mutations in the gene coding for 7-dehydrocholesterol reductase. PMID:9683613

Waterham, H R; Wijburg, F A; Hennekam, R C; Vreken, P; Poll-The, B T; Dorland, L; Duran, M; Jira, P E; Smeitink, J A; Wevers, R A; Wanders, R J

1998-01-01

499

Stress and coping in families of children with Smith-Magenis syndrome.  

PubMed

To describe stress and coping in families of children with Smith-Magenis syndrome, the present authors interviewed and received questionnaires from families of 36 children with this disorder. For measures of total stress, and of parent and family problems, the best predictors were the family's number of friends and the child's degree of impairment on the Vineland socialization domain; the single best predictor of parental pessimism was the child's degree of maladaptive behaviour. Although the stress levels of the families of children with Smith-Magenis syndrome are comparable to the levels shown by the families of children with Prader-Willi and 5p- syndromes, these levels are much higher than the stress levels reported by families of children with mixed or non-specific developmental disabilities. Stress levels may be similar across aetiologies involving high levels of maladaptive behaviour, but the correlates of family stress--particularly the moderating role of family friends--seem specific to Smith-Magenis syndrome. PMID:9828063

Hodapp, R M; Fidler, D J; Smith, A C

1998-10-01

500

The Smith Cloud and its dark matter halo: survival of a Galactic disc passage  

NASA Astrophysics Data System (ADS)

Under conservative assumptions about the Galaxy, the derived velocity of the Smith Cloud indicates that it will have undergone at least one passage of the Galactic disc. Using hydrodynamic simulations, we examine the present-day structure of the Smith Cloud and find that a dark matter supported cloud is able to reproduce the observed present-day neutral hydrogen mass, column density distribution and morphology. In this case, the dark matter halo becomes elongated owing to the tidal interaction with the Galactic disc. Clouds in models neglecting dark matter confinement are destroyed upon disc passage, unless the initial cloud mass is well in excess of what is observed today. We then determine integrated flux upper limits to the gamma-ray emission around such a hypothesized dark matter core in the Smith Cloud. No statistically significant core or extended gamma-ray emission are detected down to a 95 per cent confidence level upper limit of 1.4 × 10-10 ph cm-2 s-1 in the 1-300 GeV energy range. For the derived distance of 12.4 kpc, the Fermi upper limits set the first tentative constraints on the dark matter cross-sections annihilating into ?+?- and bbar{b} for a high-velocity cloud.

Nichols, Matthew; Mirabal, Nestor; Agertz, Oscar; Lockman, Felix J.; Bland-Hawthorn, Joss

2014-08-01