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1

Scientists in Sport, the 2012-Inspired GlaxoSmithKline Schools Outreach Programme  

ERIC Educational Resources Information Center

The GlaxoSmithKline Scientists in Sport team have worked with 4science to provide resources and offer activities for use by schools to show the relevance of science in sport. Much of the content looks at anti-doping and the science involved with detecting the misuse of banned substances. Through the development of a website, this work can continue…

Gadd, Mark

2012-01-01

2

Epristeride SmithKline Beecham.  

PubMed

Epristeride is a transition-state, noncompetitive steroid 5-alpha-reductase inhibitor under development by SmithKline Beecham for the treatment of benign prostatic hyperplasia and acne. Phase III trials for prostatic hypertrophy with an oral formulation, have been initiated in the UK, the US and Japan [188478], [219166]. In healthy male volunteers, epristeride caused a reduction in serum dihydrotestosterone levels but serum testos-terone levels remained stable. In animal studies, it showed a similar potency to finasteride for the inhibition of 5-alpha-reductase [164200]. Epristeride is licensed to Ono which has exclusive rights in Japan, South Korea and Taiwan. Recordati has co-marketing rights for epristeride [162547], [162519]. Analysts at Yamaichi estimate that epristeride will be launched in Japan between 1999 and 2000 and peak annual sales have been predicted to be over ten billion Yen [216018]. PMID:18465521

Hedge, S S

1998-05-01

3

SmithKline Beecham Biologicals Worldwide Vaccines  

NSDL National Science Digital Library

This new site from SmithKline Beecham, a "virtual gateway into the world of vaccinology," offers a host of resources on vaccination and vaccine preventable diseases. These resources are organized in three principle sections: Disease, Bio News, and Links. The first and largest section contains various reference resources for ten different diseases or disease groups, which are listed in four columns: disease, virus, epidemiology, and prevention. Although a public site, much of this information is aimed at physicians, health professionals, or other informed users. The Bio News section offers a selection of recent and archived scientific published data from peer-reviewed journals, a select list of links for breaking health news, and recent SmithKline Beecham vaccine press releases. A collection of related annotated links, sorted by country, rounds out the site. An additional site for registered medical professionals only is also available, and these users may log on via the public site. Please note that the site authors indicate that "This site is not intended for US audiences."

4

How SmithKline Beecham makes better resource-allocation decisions.  

PubMed

Major resource-allocation decisions are never easy. For a pharmaceuticals company like SmithKline Beecham, the problem is this: How do you make good decisions in a high-risk, technically complex business when the information you need to make those decisions comes largely from the project champions who are competing against one another for resources? In 1993, the company experimented with ways of depoliticizing the process and improving the quality of decision making. In most resource-allocation processes, project advocates develop a single plan of action and present it as the only viable approach. In SB's new process, the company found an effective way to get around the all-or-nothing thinking that only reinforces the project-champion culture. Project teams were required--and helped--to create meaningful alternatives to current development plans. What would they do with more money? With less? With none at all? In another important departure from common practice, SB separated the discussion of project alternatives from their financial evaluations. In doing so, SB was able to avoid the premature evaluations that kill both creativity and the opportunity to improve decision making. The new process at SB has allowed the organization to spend less time arguing about how to value its R&D projects and more time figuring out how to make them more valuable. In the end, the company learned that by tackling the soft issues around resource allocation--such as information quality, credibility, and trust--it had also addressed the hard ones: how much to invest and where to invest it. PMID:10177866

Sharpe, P; Keelin, T

1998-01-01

5

Our Client, GlaxoSmithKline is one of the world's leading research-based pharmaceutical companies. With 90000 employees world-wide, the company is  

E-print Network

are: Thrilled by mobile apps! Love to develop mobile applications for iOS and Android! Like and is looking for motivated professionals to join the team at the position of: Mobile applications developer You to experience new mobile development platforms! The role: Develops mobile applications for various GSK

Kasparian, Azniv

6

Five-year safety and immunogenicity of GlaxoSmithKline’s candidate malaria vaccine RTS,S/AS02 following administration to semi-immune adult men living in a malaria-endemic region of The Gambia  

PubMed Central

RTS,S is a pre-erythrocytic malaria vaccine candidate antigen based on the circumsporozoite surface protein of Plasmodium falciparum fused to HBsAg, incorporating a novel Adjuvant System (AS02). The first field efficacy of RTS,S/AS02 against infection was demonstrated in a trial initiated in The Gambia in 1998. This paper presents the five-year safety and immunogenicity follow up of the 306 men who were enrolled in the original trial. In the primary study men aged 18 to 45 years were randomized to receive either RTS,S/AS02 or rabies vaccine at 0, 1, 5 months followed by a booster dose at month 19. The subjects were observed for long term safety and immunogenicity continuously until month 58. Of the 153 subjects in each group at enrollment, 80 (52%) subjects in the RTS,S/AS02 group and 83 (54%) subjects in the rabies group returned for the final long-term follow-up visit at month 58. The main reason for non-attendance at month 58 was migration (76% of all drop-outs). Nine subjects in the RTS,S/AS02 group and seven in the rabies group experienced serious adverse events (SAEs) over the 58 month surveillance period, of which seven had a fatal outcome (five RTS,S/AS02 and two rabies group). None of the SAEs with fatal outcome were attributed to the study vaccine. Anti-CS antibody persistence compared to control was observed for five years, although titres had waned from post-booster levels; similar responses in anti-HBs antibody persistence were observed in initially HBsAg seronegative subjects. This study provides the first indication of the long-term safety and persistence of anti-CS and anti-HBs antibodies of the RTS,S vaccine candidate in combination with the novel AS02 Adjuvant System. PMID:19276646

Bojang, Kalifa; Milligan, Paul; Pinder, Margaret; Doherty, Tom; Leach, Amanda; Ofori-Anyinam, Opokua; Lievens, Marc; Kester, Kent; Schaecher, Kurt; Ballou, W. Ripley; Cohen, Joe

2013-01-01

7

GR-205171 (Glaxo Wellcome plc).  

PubMed

Glaxo Wellcome is developing the NK1 antagonist GR-205171 for the potential treatment of chemotherapy- and radiotherapy-induced emesis, post-operative nausea and emesis, and migraine. Phase II trials have commenced for both these indications. GR-205171 has a similar affinity for the NK1 receptor as CP-99994 [176071,193105]. Glaxo anticipates NDA and MAA filings in 2000 [244813]. A trial of GR-205171 in combination with ondansetron demonstrated the combination to be highly effective in the prevention of acute cisplatin-induced emesis. Complete responses were seen in all patients receiving high-dose GR-205171 plus ondansetron. The combination provided complete control of nausea in 16 h in 10 out of 12 patients [289484]. The compound has an ED90 value of 0.03 mg/kg against radiation-induced emesis in the ferret [207316]. GR-205171 is also active against adjuvant-induced inflammatory pain in the rat and may be of potential use in the treatment of chronic inflammatory pain. PMID:18465582

Griffiths, N M

1998-08-01

8

IMPORTANT PRESCRIBING INFORMATION Dear Healthcare Professional: GlaxoSmithKline (GSK) would like to advise you that it is changing the Pregnancy subsection of the PRECAUTIONS section in the labels for PAXIL ® (paroxetine HCl) and PAXIL CR ® (paroxetine HCl) Controlled-Release Tablets  

Microsoft Academic Search

SUMMARY • Paroxetine currently carries a Category C pregnancy precaution, indicating that there are no adequate and well-controlled studies in humans to determine the effect of paroxetine on the fetus. Labeling states that the drug should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. The label also currently includes information related to

Three Franklin Plaza

9

5:30--8:00 p.m. Celebratory Dinner  

E-print Network

to the generous financial support of Biogen Idec EMD Millipore GlaxoSmithKline Novartis Institutes for Bio and MAXWELLDWORKIN 2ND FLOOR LOBBY 29 & 33 OXFORD STREET CAMBRIDGE, MA 4:03--4:08 pm Jennifer Chen ( C

Sliz, Piotr

10

ConceptionetralisationGraphiqueJ.MFatouwww.fatou-art.com 30 June to 4 July  

E-print Network

methodological developments will be presented, following principal axes: Chemo- and bio-informatics Data mining University, Netherlands VTT Electronics, Finland McMaster University, Canada GlaxoSmithKline, UK Umeå

Ferreira, Márcia M. C.

11

76 FR 6456 - Intent To Grant an Exclusive License for a U.S. Government-Owned Invention  

Federal Register 2010, 2011, 2012, 2013

...873, issued July 3, 2001, entitled ``Inactivated Dengue Virus Vaccine,'' for the field of use involving any prophylactic and/or therapeutic purified inactivated vaccine against Dengue virus for human use. The intended licensee is GlaxoSmithKline...

2011-02-04

12

77 FR 9944 - Determination That REQUIP XL (Ropinerole Hydrochloride) Extended-Release Tablets, 3 Milligrams...  

Federal Register 2010, 2011, 2012, 2013

...GlaxoSmithKline, and initially approved on June 13, 2008. REQUIP XL is indicated for the treatment of treatment of signs and symptoms of idiopathic Parkinson's disease. REQUIP XL (ropinerole hydrochloride) extended-release tablets, 3...

2012-02-21

13

77 FR 32125 - Oncologic Drugs Advisory Committee; Notice of Meeting  

Federal Register 2010, 2011, 2012, 2013

...through Building 1. Contact Person: Caleb Briggs, Center for Drug Evaluation and Research...SmithKline Beecham (Cork) Ltd, Ireland d/b/a GlaxoSmithKline. The proposed...to a disability, please contact Caleb Briggs at least 7 days in advance of the...

2012-05-31

14

Eddie Smith Dean E. Smith  

E-print Network

Daniels Hill Ackland McCaskill Paul Green Eddie Smith Alumni Center Carmichael Auditorium Center Student Dean E. Smith Student Hall Kenan Field House Bookstore Affairs Stadium Kenan Hill Williams House Forest

Whitton, Mary C.

15

Virginia M. Kline Collection: Ecological Communities of Wisconsin  

NSDL National Science Digital Library

Dr. Virginia M. Kline was a plant ecologist who worked at the University of Wisconsin Arboretum for many years. She was an enthusiastic educator, and she also helped to develop the field of restoration ecology. For eleven years, she also team-taught the course "Vegetation of Wisconsin" with Professor Grant Cottam. As part of this work she created a series of slides designed to reflect the natural history of Wisconsin, past and present. Visitors to this digital collection can view these slides and also listen to a series of audiotapes from the course. All told, there are 1200 items in this collection, and visitors can view sets of images in galleries or perform more detailed searches across all of the items. Some of the photographs are quite beautiful and taken as a whole this collection offers a good overview of the plant life in southern Wisconsin.

16

Eddie Smith Dean E. Smith  

E-print Network

Excellence Center for Loudermilk Graham Memorial Daniels Hill Ackland McCaskill Paul Green Eddie Smith Alumni Center Carmichael Arena Center Student Dean E. Smith Student Hall Kenan Field HouseStadium Kenan Hill Williams House Forest TheatrePlaymakers Old Planetarium Morehead Henry Dramatic Center for Art Theatre

Doyle, Martin

17

Plasma Diagnostics Using K-Line Emission Profiles of Argon  

E-print Network

K-line profiles emitted from a warm dense plasma environment are used for diagnostics of Ar droplet plasmas created by high energy laser pulses. We observe temperature gradients within the Ar droplet from cold temperatures of the order of some 10 eV up to higher temperatures of about 170 eV. Non-perturbative wave functions are calculated as well as ionization energies, binding energies and relevant emission energies using a chemical {\\it ab initio} code. The plasma screening is considered within a perturbative approach to the Hamiltonian. The plasma effect influences the many-particle system resulting in energy shifts due to electron-ion and electron-electron interaction. With this approach we get a good reproduction of spectral features that are strongly influenced by ionization and excitation processes within the plasma. Comparing with the widely known FLYCHK code, counting for internal degrees of freedom (bound states) and treating pressure ionization within our quantum statistical approach leads to differ...

Chen, Yiling; Reinholz, Heidi; Röpke, Gerd

2014-01-01

18

COPD: Journal of Chronic Obstructive Pulmonary Disease, 8:1320, 2011 ISSN: 1541-2555 print / 1541-2563 online  

E-print Network

COPD: Journal of Chronic Obstructive Pulmonary Disease, 8:13­20, 2011 ISSN: 1541-2555 print / 1541 an honorarium for a talk on COPD genetics in 2006, and grant support and consulting fees from GlaxoSmithKline for two studies of COPD genetics. Dr. Silverman also received honoraria from Bayer in 2005, and from Astra

19

Expanding GSK’s Solvent Selection Guide—application of life cycle assessment to enhance solvent selections  

Microsoft Academic Search

Solvents play an important role in the pharmaceutical, chemical and allied industries, with millions of tons used and disposed of each year. GlaxoSmithKline (GSK) previously reported on the development of a Solvent Selection Guide (SSG) that provides scientists with concise environment, health and safety (EHS) data and guidance for solvents. The Guide facilitates the inclusion of EHS considerations in early

Concepción Jiménez-González; Alan D. Curzons; David J. C. Constable; Virginia L. Cunningham

2004-01-01

20

Clinical trials and drug promotion: Selective reporting of study 329  

Microsoft Academic Search

Selective reporting is prevalent in the medical literature, particularly in industry-sponsored research. In this paper, we expose selective reporting that is not evident without access to internal company documents. The published report of study 329 of paroxetine in adolescents sponsored by GlaxoSmithKline claims that \\

Jon N. Jureidini; Leemon B. McHenry; Peter R. Mansfield

21

Disconnected Youth in the Research Triangle Region: An Ominous Problem Hidden in Plain Sight  

ERIC Educational Resources Information Center

In September 2006, the North Carolina GlaxoSmithKline Foundation commissioned MDC, Inc. of Chapel Hill to analyze the problem of "disconnected youth" in the Research Triangle region, determine the current state of the region's responses to the challenge, and recommend steps to deepen and accelerate action on the issue. The research process was…

Dodson, David; Guillory, Ferrel; Lipsitz, Joan; Raper, Noah; Rausch, Christina

2008-01-01

22

BioMed Central Page 1 of 17  

E-print Network

and 3Gene Expression and Protein Biochemistry, GlaxoSmithKline, Medicines Research Center, Gunnels Wood in the interneurons of the granule cell layer though only 2 is clearly detected in granule cells. The hippocampus to be localized particularly to the pyramidal and granule cell bodies. When co-expressed in Xenopus oocytes

Dolphin, Annette C.

23

GROUPED'ANALYSEETDETHORIECONOMIQUELYONSTTIENNE CoordinationandCooperation  

E-print Network

circumstances, the same competitors invest sequentially. In the case of the dengue vaccine, Sano... Pasteur in the vaccines sector, GlaxoSmithKline and Sano...Pasteur MSD, a joint company of Sano... Aventis and Merck, brought their competing human papilloma virus vaccines to market at roughly the same time. In some other

Paris-Sud XI, Université de

24

Cellular/Molecular KCNQ/M Currents in Sensory Neurons: Significance for  

E-print Network

Cellular/Molecular KCNQ/M Currents in Sensory Neurons: Significance for Pain Therapy Gayle M19 5AW, United Kingdom, and 3Systems Research, GlaxoSmithKline, Medicines Research Centre, Stevenage and neuropathic pain. M currents [IK(M)] play a key role in regulating neuronal excitability, and mutations

Brown, David

25

For personal use. Only reproduce with permission from Elsevier Ltd Perspectives  

E-print Network

on the reputation of a powerful and important industry come when some of the biggest pharma companies are limping-- half of global pharma sales occur in the USA--slowed, thanks largely to fewer blockbuster drug launchesZeneca and GlaxoSmithKline have been extraordinarily volatile. As big pharma feels the squeeze, it seems its chief

Colquhoun, David

26

PowerPoint Presentation  

Cancer.gov

• Journal of the National Cancer Institute, ePub January 7, 2013; print: February, 2013 (issue 3) Disclosure • I am an inventor of NIH vaccine technology that has been licensed to Merck and GlaxoSmithKline, the two companies that manufacture the

27

Identifying the Right Disease Targets to Develop Better Drugs, Faster | NIH MedlinePlus the Magazine  

MedlinePLUS

... NIH Industry AbbVie Biogen Idec GlaxoSmithKline Lilly Non-Profit Organizations Alzheimer's Association Foundation for the NIH Geoffrey ... Industry Johnson & Johnson Lilly Merck Pfizer Sanofi Non-Profit Organizations American Diabetes Association Foundation for the NIH ...

28

Mathematical Robert Smith?  

E-print Network

Mathematical Modelling of Zombies Robert Smith? University of Ottawa Press #12;Robert Smith by Robert Smith? Includes bibliographical references. Issued in print and electronic formats. ISBN 978. I. Smith?, Robert J. (Robert Joseph), 1972­, editor GR581.M38 2014 398.2101'51 C2014-906565-5 C2014

Maini, Philip K.

29

Vanderbilt University 200 Smith Court  

E-print Network

John Smith Vanderbilt University 200 Smith Court Smithville, TN 37000 April 12, 20xx Ms. Janice-5000 or john.smithy.smith@vanderbilt.edu, and I thank you for your consideration. Sincerely, (Signature Here) John Smith #12;

Bordenstein, Seth

30

Joseph Smith the Prophet  

NSDL National Science Digital Library

Just a quick look at the Prophet Joseph Smith\\'s life and all that he accomplished. As you go to the site below think of the following questions: What do you think was the greatest contribution the Prophet Joseph Smith made? What can you do today to show him your appreciation and to keep the work moving forward? Key Events in the Life of Joseph Smith While looking through the church sites ask yourself the following question: Which ...

Mr. Shane Carter

2006-10-23

31

Joshua Smith Spring 2006  

E-print Network

Stormwater Utilities in Georgia Joshua Smith Spring 2006 #12;The UGA Land Use Clinic provides in Georgia Author: Joshua Smith Editor: Jamie Baker Roskie University of Georgia Land Use Clinic Spring 2006....................................................................................................10 #12;#12;1Stormwater Utilities in Georgia Stormwater Utilities in Georgia Joshua Smith Spring 2006

Rosemond, Amy Daum

32

David Smith Academic background  

E-print Network

David Smith Academic background Ph.D. in Mathematics (Algebra), Université de Sherbrooke, Canada project program (I. Assem, F. Bergeron, C. Reutenauer, D. Smith) $132,000 ($44,000 per year for 3 years. Schiffler and D. Smith, Friezes, strings and cluster variables, to appear in Glasgow Mathematcal Journal. 2

33

Can the Validation Process in Forensic DNA Typing Be Standardized? Butler, Tomsey, and Kline International Symposium on Human Identification (October 6, 2004) Page 1 of 20  

E-print Network

Can the Validation Process in Forensic DNA Typing Be Standardized? Butler, Tomsey, and Kline 15th in Forensic DNA Typing Be Standardized? John M. Butler1 , Christine S. Tomsey2 , Margaret C. Kline1 1 National State Police DNA Laboratory, Greensburg, PA 15601 Abstract Validation of procedures used in forensic DNA

34

Catalytically Driven Colloidal Patterning and Transport Timothy R. Kline,, Jodi Iwata, Paul E. Lammert,, Thomas E. Mallouk,*,,,  

E-print Network

Catalytically Driven Colloidal Patterning and Transport Timothy R. Kline,, Jodi Iwata, Paul E to the heterogeneous electrochemical reduction and oxidation of hydrogen peroxide (H2O2) on silver (Ag) and gold (Au. Introduction The electrophoretic movement of individual colloidal particles due to an applied electric field

35

Improved psoriasis with weight loss: The role of behavior factors.  

PubMed

The Center for Dermatology Research is supported by an unrestricted educational grant from Galderma Laboratories, L.P. Dr. Feldman is a consultant and speaker for Galderma, Stiefel/GlaxoSmithKline, Abbott Labs, Warner Chilcott, Janssen, Amgen, Photomedex, Genentech, BiogenIdec, and Bristol Myers Squibb. Dr. Feldman has received grants from Galderma, Astellas, Abbott Labs, Warner Chilcott, Janssen, Amgen, Photomedex, Genentech, BiogenIdec, Coria/Valeant, Pharmaderm, Ortho Pharmaceuticals, Aventis Pharmaceuticals, Roche Dermatology, 3M, Bristol Myers Squibb, Stiefel/GlaxoSmithKline, Novartis, Medicis, Leo, HanAll Pharmaceuticals, Celgene, Basilea, and Anacor and has received stock options from Photomedex. Dr. Feldman is the founder and holds stock in Causa Research. Dr. Sandoval, Ms. Pierce, and Mr. Davis have no conflicts to report. This article is protected by copyright. All rights reserved. PMID:25125221

Sandoval, L F; Pierce, A; Davis, S A; Feldman, S R

2014-08-13

36

Solar Cycle Fine Structure and Surface Rotation from Ca II K-Line Time Series Data  

NASA Technical Reports Server (NTRS)

Analysis of three and a half decades of data from the NSO/AFRL/Sac Peak K-line monitoring program yields evidence for four components to the variation: (a) the solar cycle, with considerable fine structure and a quasi-periodicity of 122.4 days; (b) a stochastic process, faster than (a) and largely independent of it, (c) a quasi-periodic signal due to rotational modulation, and of course (d) observational errors (shown to be quite small). Correlation and power spectrum analyses elucidate periodic and aperiodic variation of these chromospheric parameters. Time-frequency analysis is especially useful for extracting information about differential rotation, and in particular elucidates the connection between its behavior and fine structure of the solar cycle on approximately one-year time scales. These results further suggest that similar analyses will be useful at detecting and characterizing differential rotation in stars from stellar light-curves such as those being produced at NASA's Kepler observatory.

Scargle, Jeff; Keil, Steve; Worden, Pete

2011-01-01

37

The Adam Smith Page  

NSDL National Science Digital Library

Edward J. Harpham, Associate Professor of Government and Political Economy at the University of Texas at Dallas, developed this new site to promote the study of the moral, political, and economic ideas of Adam Smith. Anyone with an interest in Smith's ideas will find numerous resources of interest. Perhaps the most useful are Harpham's updated lists of new and forthcoming scholarly articles and books on Smith. Students will also benefit from the comprehensive bibliography of secondary works, brief commentaries on Smith's works, and the collection of related links.

Harpham, Edward J.

1998-01-01

38

An Invitation to Open Innovation in Malaria Drug Discovery: 47 Quality Starting Points from the TCAMS.  

PubMed

In 2010, GlaxoSmithKline published the structures of 13533 chemical starting points for antimalarial lead identification. By using an agglomerative structural clustering technique followed by computational filters such as antimalarial activity, physicochemical properties, and dissimilarity to known antimalarial structures, we have identified 47 starting points for lead optimization. Their structures are provided. We invite potential collaborators to work with us to discover new clinical candidates. PMID:24900261

Calderón, Félix; Barros, David; Bueno, José María; Coterón, José Miguel; Fernández, Esther; Gamo, Francisco Javier; Lavandera, José Luís; León, María Luisa; Macdonald, Simon J F; Mallo, Araceli; Manzano, Pilar; Porras, Esther; Fiandor, José María; Castro, Julia

2011-10-13

39

Drugs for bad bugs: confronting the challenges of antibacterial discovery  

Microsoft Academic Search

The sequencing of the first complete bacterial genome in 1995 heralded a new era of hope for antibacterial drug discoverers, who now had the tools to search entire genomes for new antibacterial targets. Several companies, including GlaxoSmithKline, moved back into the antibacterials area and embraced a genomics-derived, target-based approach to screen for new classes of drugs with novel modes of

David J. Payne; Michael N. Gwynn; David J. Holmes; David L. Pompliano

2006-01-01

40

JAMES E. SMITH December 2013  

E-print Network

1 JAMES E. SMITH December 2013 ADDRESS Fuqua School of Business. #12;2 PUBLICATIONS David B. Brown and James E. Smith. 2012. "Optimal Sequential Exploration: Bandits, Clairvoyants, and Wildcats." Operations Research 61 (3), 644665. James E. Smith and Canan

Reif, John H.

41

Dean of Libraries Steven Smith  

E-print Network

Dean of Libraries Steven Smith Development Director Erin Horeni-Ogle Associate Dean for Collections Dean Rita Smith Assessment Business Services Community Learning Services & Diversity Programs Hodges Library Council (Advisory) #12;Dean Steven Smith Head, Special Collections Jennifer Beals Special

Wang, Xiaorui "Ray"

42

Smith Tackles Oakland Unified  

ERIC Educational Resources Information Center

As a 20-something, Anthony "Tony" Smith had fulfilled one dream: playing professional football for the Green Bay Packers and the San Francisco 49ers. Next up, he thought, was law school, but a former mentor reminded him that he is a teacher. Smith never became a classroom teacher, but his background in sports--where he learned the power of…

Mellon, Ericka

2011-01-01

43

An Atlas of K-Line Spectra for Cool Magnetic CP Stars: The Wing-Nib Anomaly (WNA)  

NASA Astrophysics Data System (ADS)

We present a short atlas illustrating the unusual Ca II K-line profiles in upper main-sequence stars with anomalous abundances. Slopes of the profiles for 10 cool, magnetic chemically peculiar (CP) stars change abruptly at the very core, forming a deep ``nib.'' The nibs show the same or nearly the same radial velocity as the other atomic lines. The near wings are generally more shallow than in normal stars. In three magnetic CP stars, the K lines are too weak to show this shape, although the nibs themselves are arguably present. The Ca II H lines also show deep nibs, but the profiles are complicated by the nearby, strong H? absorption. The K-line structure is nearly unchanged with phase in ? CrB and ? Cir. Calculations, including NLTE, show that other possibilities in addition to chemical stratification may yield niblike cores.

Cowley, C. R.; Hubrig, S.; Kamp, I.

2006-04-01

44

Chromospheric CA II K-line variations in the sun as a star over a solar cycle  

NASA Astrophysics Data System (ADS)

The disk-averaged Ca II K profiles obtained at the Kodaikanal solar tower telescope for the period 1969-1984 are used to study the chromospheric variations in the sun as a star. The 1A index shows increases of 18 and 28 percent during the 20th and 21st cycles, respectively. The corresponding enhancements in the central intensity in the K line are 24 and 40 percent, respectively. The other K-line parameters, such as the intensity of K2 emission, K-line widths, and the V/R asymmetry, all show systematic variations over the solar cycle. Although the plage seems to be responsible for almost all the variations noticed, the participation of the bright points and the network may have to be taken into consideration to account fully for all the solar cycle-related changes.

Sivaraman, K. R.; Singh, Jagdev; Bagare, S. P.; Gupta, S. S.

1987-02-01

45

Aaron Lee Smith The Dissertation Committee for Aaron Lee Smith  

E-print Network

Copyright by Aaron Lee Smith 2009 #12;The Dissertation Committee for Aaron Lee Smith certifies Compilation by Aaron Lee Smith, B.A., M.S. Dissertation Presented to the Faculty of the Graduate School thank my family for their encouragement. Aaron Lee Smith The University of Texas at Austin December 2009

John, Lizy Kurian

46

C. E. Smith, Page 1 of 2 Cartney E. Smith  

E-print Network

C. E. Smith, Page 1 of 2 Cartney E. Smith cesmith5@illinois.edu Education University of Illinois, C. E. Smith, K. Kim, H. Kong, "Tailoring Polymersome Bilayer Permeability Improves Enhanced. Vega L., M. K. Lee, J. H. Jeong, C. E. Smith, K. Y. Lee, H. J. Chung, D. E. Leckband, H. Kong

Bashir, Rashid

47

Smith et al Supporting Information  

E-print Network

Smith et al 1 Supporting Information for Smith et al. 2006, PLoS Computational Biology 2:e161-hyperpallium apicale; HF-hippocampal formation, and M-mesopallium. #12;Smith et al 2 FigureS2,nolinkswerefoundbetweenelectrodesindifferentbirds,andnolinkswerefoundintothesoundstimulusvariable. CombinedAnalysisofAllBirds'ElectrodesPlusSound #12;Smith et al 3 Analysis of Data from Subsections

Jarvis, Erich D.

48

The Relevance of Adam Smith  

NSDL National Science Digital Library

The Federal Reserve Bank of Richmond explores the relevance of eighteenth-century economist Adam Smith in today's world. Quoting heavily from Smith's famous work The Wealth of Nations, this article summarizes many of Smith's main themes and ideas, and attempts to prove that Smith's "ideas have become so thoroughly absorbed into our intellectual heritage that they are no longer identifiable as having originated with Adam Smith."

49

Solar Cycle Variability and Surface Differential Rotation from Ca II K-line Time Series Data  

NASA Astrophysics Data System (ADS)

Analysis of over 36 yr of time series data from the NSO/AFRL/Sac Peak K-line monitoring program elucidates 5 components of the variation of the 7 measured chromospheric parameters: (a) the solar cycle (period ~ 11 yr), (b) quasi-periodic variations (periods ~ 100 days), (c) a broadband stochastic process (wide range of periods), (d) rotational modulation, and (e) random observational errors, independent of (a)-(d). Correlation and power spectrum analyses elucidate periodic and aperiodic variation of these parameters. Time-frequency analysis illuminates periodic and quasi-periodic signals, details of frequency modulation due to differential rotation, and in particular elucidates the rather complex harmonic structure (a) and (b) at timescales in the range ~0.1-10 yr. These results using only full-disk data suggest that similar analyses will be useful for detecting and characterizing differential rotation in stars from stellar light curves such as those being produced by NASA's Kepler observatory. Component (c) consists of variations over a range of timescales, in the manner of a 1/f random process with a power-law slope index that varies in a systematic way. A time-dependent Wilson-Bappu effect appears to be present in the solar cycle variations (a), but not in the more rapid variations of the stochastic process (c). Component (d) characterizes differential rotation of the active regions. Component (e) is of course not characteristic of solar variability, but the fact that the observational errors are quite small greatly facilitates the analysis of the other components. The data analyzed in this paper can be found at the National Solar Observatory Web site http://nsosp.nso.edu/cak_mon/, or by file transfer protocol at ftp://ftp.nso.edu/idl/cak.parameters.

Scargle, Jeffrey D.; Keil, Stephen L.; Worden, Simon P.

2013-07-01

50

SOLAR CYCLE VARIABILITY AND SURFACE DIFFERENTIAL ROTATION FROM Ca II K-LINE TIME SERIES DATA  

SciTech Connect

Analysis of over 36 yr of time series data from the NSO/AFRL/Sac Peak K-line monitoring program elucidates 5 components of the variation of the 7 measured chromospheric parameters: (a) the solar cycle (period {approx} 11 yr), (b) quasi-periodic variations (periods {approx} 100 days), (c) a broadband stochastic process (wide range of periods), (d) rotational modulation, and (e) random observational errors, independent of (a)-(d). Correlation and power spectrum analyses elucidate periodic and aperiodic variation of these parameters. Time-frequency analysis illuminates periodic and quasi-periodic signals, details of frequency modulation due to differential rotation, and in particular elucidates the rather complex harmonic structure (a) and (b) at timescales in the range {approx}0.1-10 yr. These results using only full-disk data suggest that similar analyses will be useful for detecting and characterizing differential rotation in stars from stellar light curves such as those being produced by NASA's Kepler observatory. Component (c) consists of variations over a range of timescales, in the manner of a 1/f random process with a power-law slope index that varies in a systematic way. A time-dependent Wilson-Bappu effect appears to be present in the solar cycle variations (a), but not in the more rapid variations of the stochastic process (c). Component (d) characterizes differential rotation of the active regions. Component (e) is of course not characteristic of solar variability, but the fact that the observational errors are quite small greatly facilitates the analysis of the other components. The data analyzed in this paper can be found at the National Solar Observatory Web site http://nsosp.nso.edu/cak{sub m}on/, or by file transfer protocol at ftp://ftp.nso.edu/idl/cak.parameters.

Scargle, Jeffrey D.; Worden, Simon P. [NASA Ames Research Center, Moffett Field, CA, 94035 (United States); Keil, Stephen L. [National Solar Observatory, P.O. Box 57, Sunspot, NM 88349 (United States)

2013-07-01

51

Adam Smith and dependency.  

PubMed

The focus of this paper is the works and life of Adam Smith, who is widely recognized as the father and founder of contemporary economics. Latent content analysis is applied to his seminal text in economics, An Inquiry into the Nature and Causes of the Wealth of Nations (1776). The results reveal that Smith considers dependence on others a problem and sees the solution to this problem in impersonalized interdependence. In addition, his views on social dependency and personal dependency, reflected in his Lectures on Jurisprudence (1963) and The Theory of Moral Sentiments (1759), are analyzed. This analysis suggests a central tension between dependence and independence in Smith's writings. The personal dependency patterns he exhibited in his life, which also suggest a tension between dependence and independence, are identified through a reading of his biographies. Based on insights from psychoanalytic literature, this paper proposes that developing the ideas in the Wealth of Nations was part of Smith's creative solution to this tension. In particular, his solution to one individual's dependence on another was through a system of impersonalized interdependence. In other words, Smith defended against his personal dependence through his economic theorizing. PMID:22712591

Ozler, Sule

2012-06-01

52

Director HR Andrew J Smith  

E-print Network

Director HR Andrew J Smith Associate Director HR Shared Services Miya Chiba Associate Director Payroll Officer John Smith Systems & Project Analyst Blair Jordan HR Reporting Analyst Yana Zhang Manager

Liley, David

53

Deborah K. Smith Senior Scientist  

E-print Network

Deborah K. Smith Senior Scientist Woods Hole Oceanographic Institution Publications: Jordan, T. H., H. W. Menard, and D.K. Smith, Density and size distribution of seamounts in the eastern Pacific inferred from wide-beam sounding data, J. Geophys. Res., 88, 10508-10518, 1983. Kim, I. I., D. K. Smith, H

Smith, Deborah K.

54

Victoria Anne Smith Curriculum Vitae  

E-print Network

Victoria Anne Smith Curriculum Vitae School of Biology anne.smith@st-andrews.ac.uk University of St-I £83,318 (of £4.5M) Oct 2006 ­ Sep 2010 #12;V. Anne Smith, Curriculum Vitae, Page 2 Past Research

Smith, V Anne

55

Copyright 2005 Veronica Susanne Smith  

E-print Network

Copyright 2005 Veronica Susanne Smith #12;Evaluating Spatial Normalization Methods for the Human Brain Veronica Susanne Smith A thesis submitted in partial fulfillment of the requirements for the Human Brain Veronica Susanne Smith Chair of the Supervisory Committee: Professor Linda S. Shapiro

Washington at Seattle, University of

56

Curriculum Vitae Douglas E. Smith  

E-print Network

6/2014 Curriculum Vitae Douglas E. Smith ADDRESS Department of Physics, University of California Foundation Fellowship, 2003 · Beckman Young Investigator Award, 2003 #12;Doug Smith CV 7/2014 2 · Searle.E. Smith Physical Review Letters 112, 248101 (2014) - Highlighted by a perspective in Science: Yann R

Smith, Douglas E.

57

Kevin Smith Sutherland House 234  

E-print Network

Kevin Smith Sutherland House 234 PMB 3342 Nashville, TN 37235 January 27, 2010 Mr. Scott at Kevin.m.smith@vanderbilt.edu or by phone at (543)3843909. Thank you for your consideration. Sincerely, Kevin Smith The cover letter needs to be in business letter format...this includes

Bordenstein, Seth

58

Presented by Jeremy C. Smith  

E-print Network

Presented by Biosystems Jeremy C. Smith Center for Molecular Biophysics Biosciences Division #12;2 Managed by UT-Battelle for the U.S. Department of Energy Smith_Biosystems_SC10 Simulation model and cellulose Length-scale1 nm 1 m * L. Petridis and J. C. Smith (2009), "A molecular mechanics force field

59

CURRICULUM VITAE ROSEMARY JOSEPHINE SMITH  

E-print Network

CURRICULUM VITAE ROSEMARY JOSEPHINE SMITH Department of Biological Sciences Idaho State University- Rosemary J. Smith Page 2 2 Graduate Courses: (the following six courses repeat after three years) Seminars Litzinger, M.N.S. 2003 #12;CV- Rosemary J. Smith Page 3 3 Mark Lung, D.A. 2002 Melissa Merrick, M.S. 2002

Smith, Rosemary J.

60

Ashley Wilder Smith's biography  

Cancer.gov

Ashley Wilder Smith, PhD, MPH is a Behavioral Scientist and Program Director in the Outcomes Research Branch of the Applied Research Program. Her program of research focuses on developing, advancing and promoting investigations related to improving current understanding of patient reported outcomes and quality care for cancer patients, survivors and families. In particular, Dr.

61

Uridine modulates neuronal activity and inhibits spike-wave discharges of absence epileptic Long Evans and Wistar Albino Glaxo/Rijswijk rats.  

PubMed

Pharmacological and functional data suggest the existence of uridine (Urd) receptors in the central nervous system (CNS). In the present study, simultaneous extracellular single unit recording and microiontophoretic injection of the pyrimidine nucleoside Urd was used to provide evidence for the presence of Urd-sensitive neurons in the thalamus and the cerebral cortex of Long Evans rats. Twenty-two neurons in the thalamus (24% of recorded neurons) and 17 neurons in the cortex (55%) responded to the direct iontophoresis of Urd. The majority of Urd-sensitive neurons in the thalamus and cortex (82% and 59%, respectively) increased their firing rate in response to Urd. In contrary, adenosine (Ado) and uridine 5'-triphosphate (UTP) decreased the firing rate of all responding neurons in the thalamus, and the majority of responding neurons in the cortex (83% and 87%, respectively). Functional relevance of Urd-sensitive neurons was investigated in spontaneously epileptic freely moving Long Evans and Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats. Intraperitoneal (i.p.) injection of 500mg/kg Urd decreased epileptic activity (210-270min after injection) in both rat strains. Intraperitoneal administration of 1000mg/kg Urd decreased the number of spike-wave discharges (SWDs) between 150-270min and 90-270min in Long Evans and WAG/Rij rats, respectively. The effect of Urd was long-lasting in both rat strains as the higher dose significantly decreased the number of SWDs even 24h after Urd injection. The present results suggest that Urd-sensitive neurons in the thalamus and the cerebral cortex may play a role in the antiepileptic action of Urd possibly via modulation of thalamocortical neuronal circuits. PMID:23707857

Kovács, Zsolt; Slézia, Andrea; Bali, Zsolt Kristóf; Kovács, Péter; Dobolyi, Arpád; Szikra, Tamás; Hernádi, István; Juhász, Gábor

2013-08-01

62

Portrait of Waldo Smith  

NASA Astrophysics Data System (ADS)

In 1944, Waldo Smith was looking for a place where he could make a difference. He had taught in universities in the United States and Turkey, and he had worked as an engineer in the field of hydrology in the United States. Somehow, a chance meeting with John Adam Fleming, AGU's long-time General Secretary, led to Waldo's becoming the first executive officer employed by the Union. That, in turn, brought him the opportunity to make a difference.

Spilhaus, Fred

2009-01-01

63

Sophia Smith Collection  

NSDL National Science Digital Library

As part of the Five College Archives Digital Access Project (mentioned in the September 25, 1998 Scout Report), Smith College has digitized some of its archival holdings relating to women's history. The Website of the Sophia Smith Collection presents still more of the Smith College holdingsof "manuscripts, photographs, periodicals and other primary sources in women's history." The site includes brief descriptions of over 300 manuscript collections, lesson plans for using primary source materials, links to additional women's history resources, and selected digital images. A permanent exhibition, Agents of Social Change, showcases some materials online. The exhibit contains pictures and digitized documents on eight 20th-century women and organizations working for women's rights. Visitors will find items such as a brochure about the National Congress of Neighborhood Women (NCNW), a grassroots feminist organization; a 1980 photo of an NCNW march on New York City Hall; Gloria Steinem photographed at the Ms. office in 1983; and fan mail to Steinem after a TV appearance.

64

Getting to know Joseph Smith  

NSDL National Science Digital Library

In these simple modules you will commit to memory 6 important dates in the life of Joseph Smith. Attempt to remember the date before clicking on the link directly under the picture. Write the dates in your journal and present the journal to Bro. Davidson for credit Joseph Smith was born in Sharon, Windsor county, Vermont in _____? Cute baby boy Birth date The first vision occurred in _____? first vision First vision date Moroni then visits the prophet in ____? Moroni Moroni visitations Joseph marries Emma ____? Emma Smith Marriage The church is officially reorganized in ____? Church restored Restoration Joseph and Hyrum martyred in ____? Martyrdom of Joseph Smith Martyrdom ...

Bro. Davidson

2010-06-09

65

Page 1 of 7 DEBORAH K. SMITH  

E-print Network

Smith - CV Page 1 of 7 DEBORAH K. SMITH Senior Scientist TEL.: (508) 289-2472 Department of Geology, and the Environment: Our Changing Oceans #12;Smith - CV Page 2 of 7 2011 NOAA OER Atlantic Basin Workshop, URI Coastal

Smith, Deborah K.

66

Genetics Home Reference: Smith-Magenis syndrome  

MedlinePLUS

... PubMed Recent literature OMIM Genetic disorder catalog Conditions > Smith-Magenis syndrome On this page: Description Genetic changes ... names Glossary definitions Reviewed December 2013 What is Smith-Magenis syndrome? Smith-Magenis syndrome is a developmental ...

67

Smith Theory Revisited William G. Dwyer  

E-print Network

Smith Theory Revisited William G. Dwyer Clarence W. Wilkerson* 1 Introduction In the late 1930's, P. A. Smith began the investigation. This thread has continued now for almost fifty years. Smith was successful in calculating the cohomology

Wilkerson, Clarence

68

Expanded Plain TEX Steven Smith  

E-print Network

Expanded Plain TEX Sept 2004 2.8.4 Karl Berry Steven Smith #12;This manual documents the Eplain Berry. Steven Smith wrote the documentation for the commutative diagram macros. (He also wrote the macros.) Some additions/corrections by Adam Lewenberg. Permission is granted to make and distribute

Mintmire, John W.

69

Evaluating baseball bat performance L. V. Smith  

E-print Network

Evaluating baseball bat performance L. V. Smith School of Mechanical and Materials Engineering address: L. V. Smith, School of Mechanical and Materials Engineering, Washington State University, Pullman

Smith, Lloyd V.

70

Circuit reconstruction tools today Stephen J Smith  

E-print Network

Circuit reconstruction tools today Stephen J Smith To understand how a brain processes information, Stanford University School of Medicine, Stanford, CA 94305, United States Corresponding author: Smith

Born, Richard

71

Sophia Smith Collection: Women's History Archives at Smith College  

NSDL National Science Digital Library

The Sophia Smith Collection at Smith College was made possible under the guidance of its first director, Margaret Storrs Grierson. In 1946, it was named in honor of the founder of Smith College and it has grown to include over 650 different thematic collections. On this page, visitors can browse through their online image collections, oral histories, and exhibits. The oral histories are quite a treat, as they include 50 in-depth interviews which document the persistence and diversity of organizing for women in the United States. Additionally, this area contains interviews on population and reproductive health and conversations with student activists at Smith College. The Online Exhibits area includes nine thematic collections. One of the most interesting among them is the Girl Zines collection, which features independent magazines that address "third wave" feminism and sexuality. Finally, visitors can use the Finding Images section to look over 300 items that include political buttons, handicrafts, and cartoons.

2012-07-13

72

Adrienne Smith Long, Doctoral Fellow  

Cancer.gov

Adrienne Smith graduated summa cum laude from McCormick School of Engineering at Northwestern University in 2008 with a Bachelors of Science in Biomedical Engineering and matriculated into the Feinberg School of Medicine at Northwestern in 2008.

73

Near-coincident K-line and K-edge energies as ionization diagnostics for some high atomic number plasmas  

SciTech Connect

For some high atomic number atoms, the energy of the K-edge is tens of eVs higher than the K-line energy of another atom, so that a few eV increase in the line's energy results in a decreasing transmission of the x-ray through a filter of the matching material. The transmission of cold iridium's Asymptotically-Equal-To 63.287 keV K{alpha}{sub 2} line through a lutetium filter is 7% lower when emitted by ionized iridium, consistent with an energy increase of {Delta}{epsilon} Asymptotically-Equal-To 10{+-}1 eV associated with the ionization. Likewise, the transmission of the K{beta}{sub 1} line of ytterbium through a near-coincident K-edge filter changes depending on plasma parameters that should affect the ionization. Systematic exploration of filter-line pairs like these could become a unique tool for diagnostics of suitable high energy density plasmas.

Pereira, N. R. [Ecopulse, Inc., P.O. Box 528, Springfield, Virginia 22150 (United States); Weber, B. V.; Phipps, D. G.; Schumer, J. W. [Naval Research Laboratory, Washington, DC 20375 (United States); Seely, J. F. [Artep, Inc., 2922 Excelsior Springs Court, Ellicott City, Maryland 21042 (United States); Carroll, J. J. [Army Research Laboratory, Adelphi, Maryland 20873 (United States); Vanhoy, J. R. [United States Naval Academy, Annapolis, Maryland 21402 (United States); Slabkowska, K.; Polasik, M. [Faculty of Chemistry, Nicolaus Copernicus University, Gagarina 7, 87-100 Torun (Poland)

2012-10-15

74

Iodine-131 Tositumomab: (131)I-anti-B1 antibody, (131)I-tositumomab, anti-CD20 murine monoclonal antibody-I-131, B1, Bexxar, (131)I-anti-B1 antibody, iodine-131 tositumomab, iodine-131 anti-B1 antibody, tositumomab.  

PubMed

Iodine-131 tositumomab [B1, Bexxar , iodine-131 anti-B1 antibody] is a murine antibody conjugated to iodine 131 that recognises and binds to the B1 (CD20) antigen which is found specifically on B lymphocytes. Iodine-131 tositumomab has a dual mechanism of action. It is capable of initiating a host immune response to those B cells to which it is attached, and it also triggers apoptosis in a significant proportion of the cells to which it binds. The product was first discovered by Coulter Corporation, Miami, in collaboration with the Dana-Farber Cancer Institute and the University of Michigan. The spin-off company Coulter Pharmaceutical, upon its formation, obtained worldwide rights to iodine-131 tositumomab. (Coulter Corporation was acquired subsequently by Beckman Instruments in October 1997. The union of the two companies produced Beckman Coulter.) In December 2000, Coulter Pharmaceutical was acquired by, and merged into, Corixa Corporation.Iodine-131 tositumomab is available for licencing in Japan. Corixa Corporation and GlaxoSmithKline signed an agreement to jointly develop and commercialise iodine-131 tositumomab. The total agreement has a potential value of up to $US132 million, plus shared profits and royalties. The two companies will jointly market the antibody in the US following regulatory approval. Corixa Corporation has announced it expects iodine-131 tositumomab to be approved in the US for non-Hodgkin's lymphoma (NHL). Under the terms of the original agreement, GlaxoSmithKline will receive exclusive marketing rights outside the US, excluding Japan. However, an amended agreement between the two companies will allow Corixa Corporation to also market the product outside the US. In February 2003, the European Commission granted iodine-131 tositumomab orphan-drug designation. Corixa Corporation and GlaxoSmithKline also intend to jointly investigate the use of the product in other indications. GlaxoSmithKline may also receive access to second generation anti-CD20 compounds under its agreement with Corixa Corporation. In May 2003, Corixa Corporation entered into an agreement that will see GlaxoSmithKline market Bexxar in Canada. Under the terms of the agreement, Corixa Corporation will manufacture and supply the product to GlaxoSmithKline, who will register, market and sell it in Canada. In October 2001, Amersham PLC, a supplier of medical equipment, announced that its Amersham Health unit had signed a marketing agreement with Corixa Corporation. The agreement allows Amersham Health to market iodine-131 tositumomab in Europe. Corixa Corporation formed agreements with Boehringer Ingelheim Pharma KG and Lonza Biologics to produce the B1 antibody and radiolabelling of the antibody has been contracted out to MDS Nordion.Iodine-131 tositumomab has received orphan drug and fast track designation for the treatment of NHL. Corixa Corporation submitted a Biologics Licence Application (BLA) to the US FDA in 1999, seeking permission to market Bexxar in the US for the treatment of relapsed or refractory, low grade or transformed low grade B-cell NHL. Following a priority review, the US FDA requested that Corixa Corporation reformat certain sections and perform additional analyses of existing data in its BLA. Corixa Corporation and GlaxoSmithKline resubmitted their BLA to the US FDA in September 2000. The BLA was subsequently accepted by the US FDA in November 2000. However, in March 2001, the US FDA requested additional information in its complete review letter to Corixa Corporation and marketing partner GlaxoSmithKline. The two companies submitted data pertaining to the chemistry, manufacturing and controls section of the BLA, and to the majority of the questions regarding the clinical section of the BLA in August 2001. Corixa Corporation and GlaxoSmithKline submitted the remainder of the response to the US FDA in September 2001, following an independent review of clinical trial data. In March 2002, Corixa Corporation received another complete review letter from the US FDA, which stated that additional clinical trials would h

2003-01-01

75

Disease Caused by Rotavirus Infection  

PubMed Central

Although rotavirus vaccines are available, rotaviruses remain the major cause of childhood diarrheal disease worldwide. The Rotarix (GlaxoSmithKline Biologicals Rixensart, Belgium) and RotaTeq (Merck and Co., Inc. Whitehouse Station, New Jersey, USA) vaccines are effective for reducing the morbidity and mortality of rotavirus infection. This article aims to assess the epidemiology of rotaviral gastroenteritis and the efficacy and effectiveness of licensed rotavirus vaccines. This review concludes by presenting challenges in the field that require further exploration by and perspectives from basic and translational research in the future. PMID:25553142

Lin, Che-Liang; Chen, Shou-Chien; Liu, Shyun-Yeu; Chen, Kow-Tong

2014-01-01

76

International team finds a bioactive protein from ancient medicinal plant may help combat melanoma and other cancers  

Cancer.gov

An international team led by scientists from the University of Medicine and Dentistry of New Jersey-School of Osteopathic Medicine, has found that a protein from the seeds of a plant used for centuries in traditional medicines may be able to halt the spread of melanoma, a lethal form of skin cancer. The study included collaborators from Nagoya University, the University of Michigan and GlaxoSmithKline. The University of Medicine and Dentistry of New Jersey is an academic affiliate of the Cancer Institute of New Jersey.

77

Plasmepsin inhibitory activity and structure-guided optimization of a potent hydroxyethylamine-based antimalarial hit.  

PubMed

Antimalarial hit 1 SR (TCMDC-134674) identified in a GlaxoSmithKline cell based screening campaign was evaluated for inhibitory activity against the digestive vacuole plasmepsins (Plm I, II, and IV). It was found to be a potent Plm IV inhibitor with no selectivity over Cathepsin D. A cocrystal structure of 1 SR bound to Plm II was solved, providing structural insight for the design of more potent and selective analogues. Structure-guided optimization led to the identification of structurally simplified analogues 17 and 18 as low nanomolar inhibitors of both, plasmepsin Plm IV activity and P. falciparum growth in erythrocytes. PMID:24900843

Jaudzems, Kristaps; Tars, Kaspars; Maurops, Gundars; Ivdra, Natalija; Otikovs, Martins; Leitans, Janis; Kanepe-Lapsa, Iveta; Domraceva, Ilona; Mutule, Ilze; Trapencieris, Peteris; Blackman, Michael J; Jirgensons, Aigars

2014-04-10

78

Cowboy Photographer: Erwin E. Smith  

NSDL National Science Digital Library

While many are familiar with the romantic notion of the American cowboy as crafted by Frederic Remington and Charles M. Russell, few share intimate knowledge of a lesser known artist, Erwin E. Smith. This online exhibit, created by the Amon Carter Museum in Texas, seeks to rectify that situation through this extensive archive of photographs by Smith that capture the world of the cowboy around the turn of the 20th century. Smith grew up in Texas collecting prints of paintings by artists like George Catlin and Frederic Remington. He later ended up studying art with Lorado Taft at the Art Institute of Chicago, and then at the School of the Boston Museum of Fine Arts. Smith later moved back West, and between 1905 and 1912, he took thousands of photographs on ranches throughout Texas, New Mexico, and Arizona. The photographs available online here are divided into several main sections for convenient browsing, including Cowhand clothing, Rodeo, and Ranches. Along with a biography of Smith, the site also includes a glossary of terms used by cowboys and ranchers, as well as several teaching resources for educators.

79

Fundamental Ideas of Mathematics Instructor: Sam Smith  

E-print Network

Math 225 Fundamental Ideas of Mathematics Syllabus Fall 2013 Instructor: Sam Smith Office: Barbelin 228, 610-660-1559, smith@sju.edu Office Hours: Tue, Thur 12:00-2:00 or by appointment. Text: Chartrand

Smith, Sam

80

STEVEN E. SMITH University of Arizona  

E-print Network

30 Gramas STEVEN E. SMITH University of Arizona Tucson, Arizona MARSHALL R. HAFERKAMP USDA herbivores on rangelands (Peden et al., 1974; Smith et al., 1996; Hart and Ashby, 1998; Sims and Risser, 2000

Smith, Steven E.

81

Towards robot audition Leslie S. Smith  

E-print Network

Towards robot audition Leslie S. Smith Department of Computing Science and Mathematics, University in illumination, and auditory systems can detect changes in room reverberation. #12;2 Leslie S. Smith Another key

Smith, Leslie S.

82

The RB Language Jonathan M. Smith  

E-print Network

­­ ­­ The RB Language Jonathan M. Smith Distributed Systems Laboratory Department of Computer of an attempt to generate more practical examples of the scheme described by Smith and Maguire for ``competitive

83

Am I spikes over time? Leslie Smith  

E-print Network

Am I spikes over time? Leslie Smith Computing Science and Mathematics University of Stirling Stirling FK9 4LA, UK Email: l.s.smith@cs.stir.ac.uk URL: http://www.cs.stir.ac.uk/~lss Acknowledgements: EU

Smith, Leslie S.

84

Introducing Reference Semantics via Refinement Graeme Smith  

E-print Network

Introducing Reference Semantics via Refinement Graeme Smith Software Verification Research Centre, University of Queensland, Australia smith@svrc.uq.edu.au Abstract. Two types of semantics have been given

Smith, Graeme

85

Stepwise Development from Ideal Specifications Graeme Smith  

E-print Network

Stepwise Development from Ideal Specifications Graeme Smith Software Verification Research Centre University of Queensland, Australia smith@svrc.uq.edu.au Abstract The stepwise development of a program using

Smith, Graeme

86

Adversaries and Information Leaks Geoffrey Smith  

E-print Network

Adversaries and Information Leaks (Tutorial) Geoffrey Smith School of Computing and Information-Verlag Berlin Heidelberg 2008 #12;384 G. Smith ­ The program c has direct access to the sensitive information

Smith, Geoffrey

87

Jason C Smith Department of Physical Oceanography  

E-print Network

, Lord, Smith, Ryder, Galbraith, Fairall, Stalin, Andueza, Tomlinson, 2004 "Stratus Ocean Reference, Serpetzoglou, Tomlinson, Tisandie, Bustos, 2005. "Stratus Ocean Reference Station (20S, 85W), Mooring Recovery, Lord, Smith, Bouchard, Fairall, Pezoa, Bariteau, Lundquist, Ghate, Castro, Cisternas, 2006. "Stratus

Yu, Lisan

88

Smith Purcell radiation from femtosecond electron bunches  

E-print Network

We present theoretical and experimental results from a Smith-Purcell radiation experiment using the electron beam from a 17 GHz high gradient accelerator. Smith- Purcell radiation occurs when a charged particle travels ...

Korbly, Stephen E

2005-01-01

89

RANDALL KNOWLES SMITH High Energy Astrophysics Division  

E-print Network

., Foster, Adam, Smith, Randall K., Kat- suda, Satoru, Yoshii, Rie, 2012, Astrophysical Journal, 749, 137 9RANDALL KNOWLES SMITH High Energy Astrophysics Division Smithsonian Astrophysical Observatory, MS 2 / Edited Proceedings Handbook of X-ray Astronomy, K. A. Arnaud, R. K. Smith, & A. Siemiginowska 2011

90

BOUNDS FOR SPECTRAL CLUSTERS HART F. SMITH  

E-print Network

Lq BOUNDS FOR SPECTRAL CLUSTERS HART F. SMITH Abstract. In these notes, we review recent results] establish the same estimates under the assumption that the metric is C1,1. It is known by examples of Smith to the wave equation. The author was supported in part by NSF grant DMS-0140499. 1 #12;2 HART F. SMITH

Smith, Hart F.

91

Math in Microbiology Hal L. Smith  

E-print Network

Math in Microbiology Hal L. Smith PSA 631 halsmith@asu.edu School of Mathematics and Statistics Arizona State University H.L.Smith (A.S.U.) Math in Microbiology Microbiology, January 2009 1 / 22 #12 for Nutrient 4 Bacteriophage and Bacteria in Chemostat 5 Food Chain H.L.Smith (A.S.U.) Math in Microbiology

Smith, Hal

92

Arras User's Manual John B. Smith  

E-print Network

Arras User's Manual TR85-036 1985 John B. Smith The University of North Carolina at Chapel Hill'S MANUAL John B. Smith Department or Computer Science University or North Carolina Chapel Hill, North Carolina 27514 Copyright© 1984 by John B. Smith #12;Starling ARRAS Note for those not using TUCC: The ARRAS

North Carolina at Chapel Hill, University of

93

Derek J. Smith Department of Computer Science  

E-print Network

Derek J. Smith Candidate Department of Computer Science Department This dissertation is approved, Modeling, and Application to Vaccine Design by Derek J. Smith B.Sc., Computer Science, University Mexico Albuquerque, New Mexico December 1997 #12;#12;c 1997, Derek J. Smith v #12;#12;For Dorothy, Mabel

Forrest, Stephanie

94

The Coverage of Operational Scott F. Smith  

E-print Network

The Coverage of Operational Semantics Scott F. Smith Department of Computer Science The Johns (Talcott 1989), types and objects (Gordon and Rees 1996), and distributed objects (Agha, Mason, Smith text can 1 #12;2 Smith distinguish the two. This program text can be viewed as a particular "test

Smith, Scott F.

95

Smith Theory Revisited William G. Dwyer  

E-print Network

Smith Theory Revisited William G. Dwyer Clarence W. Wilkerson \\Lambda 1 Introduction In the late 1930's, P. A. Smith began the investigation of the cohomological properties of a group G of prime order fifty years. Smith was successful in calculating the cohomology of the the fixed point sets

Wilkerson, Clarence

96

Smith Theory Revisited William G. Dwyer  

E-print Network

Smith Theory Revisited William G. Dwyer Clarence W. Wilkerson 1 Introduction In the late 1930's, P. A. Smith began the investigation of the cohomological properties of a group G of prime order p. Smith was successful in calculating the cohomology of the the fixed point sets for involutions

Wilkerson, Clarence

97

Arthur Smith, Local Baptist Pastor.  

ERIC Educational Resources Information Center

Written and published by the students at Gary High School this volume has three articles dealing with East Texas life. The first "Arthur Smith" (David Hancock and others) is an account of growing up in Marian County, Texas is described by the local Baptist minister. The pastor begins with the year of his birth and gives detailed information about…

Heaton, Moss, Ed.

1985-01-01

98

Susan Krebs-Smith's biography  

Cancer.gov

Susan Krebs-Smith, PhD, is the Chief of the Risk Factor Monitoring and Methods Branch of the Applied Research Program. In that capacity, she oversees a program of research on the surveillance of risk factors related to cancer, methodological issues to improve the assessment of those factors, and issues related to guidance and food policy.

99

Smith Mammal Body Mass Data  

NSDL National Science Digital Library

Data compiled on body mass information for 5731 mammalian species. Felisa A. Smith, S. Kathleen Lyons, S. K. Morgan Ernest, Kate E. Jones, Dawn M. Kaufman, Tamar Dayan, Pablo A. Marquet, James H. Brown, and John P. Haskell. 2003. Body mass of late Quaternary mammals. Ecology 84:3403

Ethel Stanley (Beloit College; Biology)

2009-01-10

100

The same face of the two Smiths: Adam Smith and Vernon Smith  

Microsoft Academic Search

Going from personal to impersonal exchange seems to be a relevant feature that allows humans to develop complex societies and grow prosperous. Adam Smith's idea of moral imagination, embodied in the impartial spectator and achieved through sympathy, may integrate and complement today's evolutionary biology and experimental economic explanations, providing the missing key as to how we generate and internalize those

Maria Pia Paganelli

2011-01-01

101

Econophysical visualization of Adam Smith’s invisible hand  

NASA Astrophysics Data System (ADS)

Consider a complex system whose macrostate is statistically observable, but yet whose operating mechanism is an unknown black-box. In this paper we address the problem of inferring, from the system’s macrostate statistics, the system’s intrinsic force yielding the observed statistics. The inference is established via two diametrically opposite approaches which result in the very same intrinsic force: a top-down approach based on the notion of entropy, and a bottom-up approach based on the notion of Langevin dynamics. The general results established are applied to the problem of visualizing the intrinsic socioeconomic force-Adam Smith’s invisible hand-shaping the distribution of wealth in human societies. Our analysis yields quantitative econophysical representations of figurative socioeconomic forces, quantitative definitions of “poor” and “rich”, and a quantitative characterization of the “poor-get-poorer” and the “rich-get-richer” phenomena.

Cohen, Morrel H.; Eliazar, Iddo I.

2013-02-01

102

Fukushima to receive Smith Medal  

NASA Astrophysics Data System (ADS)

The 1990 Waldo E. Smith Medal for extraordinary service to geophysics will be given to Naoshi Fukushima, who earned an international reputation for his pioneering work in geomagnetic disturbance and ionospheric electric currents. Now retired from the University of Tokyo, Japan, Fukushima is being cited for his public service to international geophysics, and, in particular, his contributions to the International Association of Geomagnetism and Aeronomy, of which he was Secretary General from September 1975 to August 1983.The Smith Medal will be presented as part of the AGU Fall Meeting Honors Night festivities, Wednesday, December 5, in San Francisco, Calif. Three James B. Macelwane Medals, the John Adam Fleming Medal, and the Maurice Ewing Medal will also be presented (see Eos, February 20, 1990, p. 294).

103

Street & Smith's Preservation Access Project  

NSDL National Science Digital Library

For thousands of Americans throughout the 19th and early 20th centuries, dime novels and pulp magazines were their first experiences with the emerging world of mass-produced material culture. One such purveyor was the Street & Smith publishing house, which began in 1855 and published a wide variety of popular literature (such as homemaking magazines, comics, and dime novels) for over 100 years. These products didn't often have a great deal of originality, as the company viewed fiction as a commodity, and editors dictated plots and characters to writers, a list that included Horatio Alger, Upton Sinclair, and Jack London. This Web site, an online exhibit presented by the Syracuse University Library, pays homage to this publishing house with a number of scanned digitized images of the Street & Smith dime novels, a cover art gallery, and a collection of images immortalizing that most famous comic strip character, the Yellow Kid.

104

William Smith (1769-1839)  

NSDL National Science Digital Library

This brief history of William Smith, who initiated the Principle of Faunal Succession, covers his early education, his employment as an assistant surveyor to Edward White, and his time as construction supervisor of the Somerset Canal in southwestern England. The text explains his production of a geological map of England and final recognition in 1831, when he received the Wollaston Medal, the highest honor awarded each year for outstanding achievement in geology by the Geological Society of London.

105

Pricing strategies for combination pediatric vaccines and their impact on revenue: Pediarix or Pentacel?  

PubMed

This paper analyzes pricing strategies for pediatric combination vaccines and their impact on the United States pediatric vaccine market. Three pharmaceutical companies compete pairwise with each other over the sale of vaccines containing two or three antigens per injection. Specific emphasis is placed on examining the competition between two pentavalent vaccines: GlaxoSmithKline's Pediarix (DTaP-HepB-IPV) and Sanofi Pasteur's Pentacel (DTaP-IPV/Hib). The main contribution of the paper is to provide a methodology for analyzing pricing strategies of directly competing, partially overlapping, and mutually exclusive combination vaccines in the United States pediatric vaccine market, with the goal of maximizing each pharmaceutical company's expected revenue. The resulting analysis shows that Pentacel is not competitively priced when compared to Pediarix, its strongest competitor, for federal contract prices ending 31 March 2010. Accordingly, Sanofi Pasteur should expect to generate low revenue upon market entry, while Pediarix remains well priced, with GlaxoSmithKline able to generate a high level of revenue at the expense of Sanofi Pasteur. The proposed pricing approach suggests an appropriate price for Pentacel whereby a substantial increase in expected revenue can be realized. PMID:20402282

Robbins, Matthew J; Jacobson, Sheldon H; Sewell, Edward C

2010-03-01

106

Effects of different chlorhexidine pretreatments on adhesion of metal brackets in vitro  

PubMed Central

Objective To investigate the effect of chlorhexidine applications in various forms and concentrations on adhesion and failure modes of metal brackets in vitro. Material and methods Ninety bovine enamel specimens were allocated to six groups (n=15). Metal brackets were bonded on all specimens after chlorhexidine pre-treatments forming the following groups: (1) untreated specimens (control); (2) 40% varnish (EC40, Biodent BV, Netherlands), remnants removed with brushing mimicking patient cleaning; (3) 40% varnish (EC40), remnants removed with brushing mimicking professional cleaning; (4) 1% varnish (Cervitec Plus, Ivoclar vivadent, Schaan, Liechtenstein), remnants not removed; (5) brushed with% 1 gel (Corsodyl, GlaxoSmithKline, Münchenbuchsee, Germany), remnants not removed; (6) immersed in 0.07% mouthrinse (Corsodyl, GlaxoSmithKline, Münchenbuchsee, Germany), remnant not rinsed. Debonding of brackets was performed using a universal testing machine. Data were analysed using one-way ANOVA and post-hoc Scheffé test. Results Group 4 performed significantly inferior than all the other groups and the control. Group 4 presented the highest number of adhesive failures at the enamel-resin interface whereas in other groups no failures at adhesive-resin interface was observed. Conclusion Presence of chlorhexidine varnish prior to bracket bonding adversely affects adhesion. Concentration of chlorhexidine pre-treatment has no influence on shear bond strength. PMID:23273111

2012-01-01

107

Richard Smith, Director smith@sfu.ca Adam Holbrook, Associate Director  

E-print Network

CONTACT Richard Smith, Director smith@sfu.ca Adam Holbrook, Associate Director jholbroo Clayman Andrew Feenberg Andy Hira Adam Holbrook Martin Laba Brian Lewis Elicia Maine Stelvia Matos Ian McCarthy Roman Onufrijchuk Richard Smith David Zandvliet RESEARCHERS & ASSOCIATES Nancy Duxbury Gordon Gow

108

ON MONOIDS WITH A SINGLE DEFINING RELATOR G. C. Smith  

E-print Network

. Smith Abstract. This paper concerns single-relator monoid presentations, and di* *scusses Eileen and Roy Smith on the occasion of their Golden Wedding Anniversary;2 G. C. SMITH Results The first result shows that Johnson

Smith, Geoff

109

PROPAGATION OF SINGULARITIES FOR ROUGH METRICS HART F. SMITH  

E-print Network

PROPAGATION OF SINGULARITIES FOR ROUGH METRICS HART F. SMITH Abstract. We use a wave packet the Simons Foundation (# 266371 to Hart Smith). 1 #12;2 HART F. SMITH H¨ormander's theorem [9] on propagation

Smith, Hart F.

110

Genetics Home Reference: Smith-Lemli-Opitz syndrome  

MedlinePLUS

... PubMed Recent literature OMIM Genetic disorder catalog Conditions > Smith-Lemli-Opitz syndrome On this page: Description Genetic ... names Glossary definitions Reviewed July 2007 What is Smith-Lemli-Opitz syndrome? Smith-Lemli-Opitz syndrome is ...

111

Guide to the Logan Pearsall Smith Collection.  

ERIC Educational Resources Information Center

A guide to the Logan Pearsall Smith Collection at Trinity University Elizabeth Coates Maddux Library in San Antonio, Texas provides a descriptive overview of the collected works of this renowned epigrammatist, critic, essayist, biographer, and authority on the English language. The guide includes a brief biography of Smith (1865-1946), detailed…

Pettit, Katherine Denshaw

112

Adam Smith and the Rhetoric of Style.  

ERIC Educational Resources Information Center

Historians of rhetoric have generally accepted the view that Adam Smith rejected the principles of classical rhetoric. However, while there can be no doubt that Smith greatly truncated the five classical arts of rhetoric (invention, arrangement, style, memory, and delivery) by reducing his concerns largely to style and arrangement, he did not…

Moran, Michael G.

113

Nelson G. Hairston Frederick E. Smith  

E-print Network

Nelson G. Hairston Frederick E. Smith Lawrence B. Slobodkin Department of Zoology, The University of Michigan Founded the Department of Ecology & Evolution at Stony Brook University (NY) Frederick SmithFrederick. Large Carnivores and the Conservation of Biodiversity. Washington, DC: Island Press, 2005. Print

Jodice, Patrick

114

Bringing Sally Smith's Vision to Manayunk  

ERIC Educational Resources Information Center

In this article, the author narrates her application of what she learned from her internship at Sally Smith's Lab School of Washington to her new school and shares the favorable impact it had brought on her teaching career. The author shares her first exposure to the powerful effects of Smith's "Live It, Learn It" methodology as she encountered a…

Ford, Jackie

2010-01-01

115

The Treatment of Smith's Invisible Hand  

ERIC Educational Resources Information Center

Adam Smith used the metaphor of an invisible hand to represent the instincts of human nature that direct behavior. Moderated by self-control and guided by proper institutional incentives, actions grounded in instincts can be shown to generate a beneficial social order even if not intended. Smith's concept, however, has been diluted and distorted…

Wight, Jonathan B.

2007-01-01

116

Forensic Entomology & Taphonomy Smith Hall Room 125  

E-print Network

ENTM 295T Forensic Entomology & Taphonomy Smith Hall Room 125 Monday 8:30 ­ 11:20 a.m. Fall and on the postmortem fate of human remains. Ralph Williams, Ph.D. D-ABFE Professor of Entomology Entomology, Smith B9

Ginzel, Matthew

117

Smith Predictor Design for Robust Performance  

Microsoft Academic Search

A method is outlined for designing Smith predictor controllers that provide robust performance despite real parameter uncertainties in the process model. Insight into the design process is gained by viewing the Smith predictor from the perspective of Internal Model Control. Performance requirements are written in terms of a frequency-domain weight restricting the magnitude of the closed-loop sensitivity function. A general

Daniel L. Laughlin; Manfred Morari

1987-01-01

118

A Survey of Process Migration Mechanisms Jonathan M. Smith  

E-print Network

A Survey of Process Migration Mechanisms Jonathan M. Smith Computer Science Department Columbia Migration Mechanisms Jonathan M. Smith Computer Science Department Columbia University New York, NY 10027

Smith, Jonathan M.

119

Environmental assessment: Deaf Smith County site, Texas  

SciTech Connect

In February 1983, the US Department of Energy (DOE) identified a location in Deaf Smith County, Texas, as one of nine potentially acceptable sites for a mined geologic repository for spent nuclear fuel and high-level radioactive waste. To determine their suitability, the Deaf Smith County site and the eight other potentially sites have been evaluated in accordance with the DOE's General Guidelines for the Recommendation of Sites for the Nuclear Waste Repositories. The Deaf Smith County site is in the Permian Basin, which is one of five distinct geohydrologic settings considered for the first repository. On the basis of the evaluations reported in this EA, the DOE has found that the Deaf Smith County site is not disqualified under the guidelines. On the basis of these findings, the DOE is nominating the Deaf Smith County site as one of the five sites suitable for characterization. 591 refs., 147 figs., 173 tabs.

Not Available

1986-05-01

120

Environmental assessment: Deaf Smith County site, Texas  

SciTech Connect

In February 1983, the US Department of Energy (DOE) identified a location in Deaf Smith County, Texas, as one of the nine potentially acceptable sites for mined geologic repository for spent nuclear fuel and high-level radioactive waste. To determine their suitability, the Deaf Smith County site and eight other potentially acceptable sites have been evaluated in accordance with the DOE's General Guidelines for the Recommendation of Sites for the Nuclear Waste Repositories. The Deaf Smith County site is in the Permian Basin, which is one of five distinct geohydrologic settings considered for the first repository. On the basis of the evaluations reported in this EA, the DOE has found that the Deaf Smith County site is not disqualified under the guidelines.

Not Available

1986-05-01

121

Environmental assessment, Deaf Smith County site, Texas  

SciTech Connect

The Nuclear Waste Policy Act of 1982 (42 USC sections 10101-10226) requires the environmental assessment of a proposed site to include a statement of the basis for nominating a site as suitable for characterization. Volume 2 provides a detailed statement evaluating the site suitability of the Deaf Smith County Site under DOE siting guidelines, as well as a comparison of the Deaf Smith County Site to the other sites under consideration. The evaluation of the Deaf Smith County Site is based on the impacts associated with the reference repository design, but the evaluation will not change if based on the Mission Plan repository concept. The second part of this document compares the Deaf Smith County Site to Davis Canyon, Hanford, Richton Dome and Yucca Mountain. This comparison is required under DOE guidelines and is not intended to directly support subsequent recommendation of three sites for characterization as candidate sites. 259 refs., 29 figs., 66 refs. (MHB)

Not Available

1986-05-01

122

J. E. Smith C. M. Smith C. L. Hunter An experimental analysis of the effects of herbivory and nutrient  

E-print Network

REPORT J. E. Smith á C. M. Smith á C. L. Hunter An experimental analysis of the effects become increasingly common (Smith et al. 1981; Hughes et al. 1987; Lapointe 1997; McClanahan et al. 1999 lead to substantial changes in ben- thic community structure (Smith et al. 1981; Littler and Littler

Smith, Jennifer E.

123

The Devil in Mr. Smith: A Conversation with Jonathan Z. Smith  

ERIC Educational Resources Information Center

This interview was recorded in November 2012 in Jonathan Z. Smith's Hyde Park graystone. Professor Smith offers insights into how he thinks about his classroom teaching and his students' learning through descriptions of various assignments and classroom activities he has developed over more than forty years of teaching. The discussion…

Smith, Jonathan Z.; Pearson, Thomas; Gallagher, Eugene V.; Jensen, Tim; Fujiwara, Satoko

2014-01-01

124

STS-110 Crew Interviews: Steve Smith  

NASA Technical Reports Server (NTRS)

STS-110 Mission Specialist Steve Smith is seen during this preflight interview, where he gives a quick overview of the mission before answering questions about his inspiration to become an astronaut and his career path. Smith outlines his role in the mission in general, and specifically during the docking and extravehicular activities (EVAs). He describes the payload (S0 Truss and Mobile Transporter) and the dry run installation of the S0 truss that will take place the day before the EVA for the actual installation. Smith discusses the planned EVAs in detail and outlines what supplies will be left for the resident crew of the International Space Station (ISS). He ends with his thoughts on the most valuable aspect of the ISS.

2002-01-01

125

STS-103 Crew Interviews: Steven Smith  

NASA Technical Reports Server (NTRS)

Live footage of a preflight interview with Mission Specialist Steven L. Smith is seen. The interview addresses many different questions including why Brown became an astronaut, the events that led to his interest, any role models that he had, and his inspiration. Other interesting information that this one-on-one interview discusses is an explanation of the why this required mission to service the Hubble Space Telescope must take place at such an early date, replacement of the gyroscopes, transistors, and computers. Also discussed is Smith's responsibility during any of the planned space walks scheduled for this mission.

1999-01-01

126

Specifying mode requirements of embedded systems Graeme Smith  

E-print Network

Specifying mode requirements of embedded systems Graeme Smith Software Verification Research Centre University of Queensland, Australia Email: smith@svrc.uq.edu.au Abstract This paper presents a formal

Smith, Graeme

127

Rapid location of mount points JONATHAN M. SMITH  

E-print Network

­­ ­­ Rapid location of mount points JONATHAN M. SMITH Computer Science Department, Columbia ``core'' is ``/u2/smith/core''. The current directory is a directory­valued variable. It is an implied

128

The Task of the Referee Alan Jay Smith  

E-print Network

The Task of the Referee * Alan Jay Smith Computer Science Division EECS Department University professional. Typically, referees learn to ¡ ¡ ¡ ¡ ¡ ¡ ¡ ¡ ¡ ¡ ¡ ¡ ¡ ¡ ¡ ¡ ¡ * Prof. Smith's research

Torr, Philip H. S.

129

Dual Models of Permutation Problems Barbara M. Smith  

E-print Network

Dual Models of Permutation Problems Barbara M. Smith School of Computing & Mathematics University of Huddersfield Huddersfield HD1 3DH, U.K. b.m.smith@hud.ac.uk Abstract. A constraint satisfaction problem

Smith, Barbara M.

130

Principles of Secure Information Flow Analysis Geoffrey Smith  

E-print Network

Principles of Secure Information Flow Analysis Geoffrey Smith School of Computing and Information to explain the #12;2 Geoffrey Smith principles underlying secure information flow analysis and to discuss

Smith, Geoffrey

131

Organizzato da: Christopher Smith, British School at Rome  

E-print Network

Organizzato da: Christopher Smith, British School at Rome Attilio Mastrocinque, Università di LIPPOLIS, Attilio MASTROCINQUE, Christopher SMITH - Presentazione 10.00 ­ 10.30 Elio LO CASCIO - I fora e

Guidoni, Leonardo

132

!! ARI No. 32 (2009) Odontoponera denticulata (F. Smith) (Formicidae: Ponerinae),  

E-print Network

!! ARI No. 32 (2009) " #!" Odontoponera denticulata (F. Smith) (Formicidae: Ponerinae), a distinct-shi, 890-0065 Japan !" #$% &'()*+,-./0123456.6789: Odontoponera denticulata (F. Smith) );? 123456.6@ Odontoponera )ASmith)VWX YOZ

Villemant, Claire

133

Adam Smith, Behavioral Economist Nava Ashraf, Colin F. Camerer and  

E-print Network

Adam Smith, Behavioral Economist Nava Ashraf, Colin F. Camerer and George Loewenstein I n The Wealth of Nations, published in 1776, Adam Smith famously argued that economic behavior was motivated over whether Adam Smith's view of human motivation as expressed in The Theory of Moral Sentiments

Greer, Julia R.

134

Working Papers m 2011:04 Rediscovering Adam Smith  

E-print Network

Working Papers m 2011:04 Rediscovering Adam Smith HowThe Theory of Moral Sentiments canexplainemergingevidencein experimentaleconomics Douglas E. Stevens #12;AdamSmithResearchFoundation Working Papers Series.AuthorsareadvisedtokeepinmindthegeneralistaudienceoftheWorkingPapersseries andavoidtechnicallanguageandextensivefootnotesasmuchaspossible. m TheAdamSmithResearchFoundation(ASRF)isbasedwithintheCollegeofSocialSciencesat the

Guo, Zaoyang

135

RESEARCH ARTICLE Matthew W. Bettridge Barton L. Smith  

E-print Network

RESEARCH ARTICLE Matthew W. Bettridge Ã? Barton L. Smith Robert E. Spall Aerodynamic jet steering of the suction flow is entrained. Vectoring with multiple suction and blowing slots was reported by Smith et al was investigated experimentally by Smith and Glezer (2002) and numerically by Guo et al. (2002, 2003). Synthetic

Smith, Barton L.

136

Tanya M. Smith Department of Human Evolutionary Biology  

E-print Network

1 Tanya M. Smith Department of Human Evolutionary Biology Harvard University 11 Divinity Avenue. * SUNY Geneseo Foundation Research Grant, 1995. #12;2 Peer-Reviewed Publications 52. Smith, T.M. (in., Stinespring Harris, A., Reid, D.J., Larsen, C.S., Hutchinson, D., Smith, T.M. (in review) Chronology of linear

Smith, Tanya M.

137

WaveCurrent Interactions in Finite Depth JEROME A. SMITH  

E-print Network

Wave­Current Interactions in Finite Depth JEROME A. SMITH Scripps Institution of Oceanography, La (Longuet-Higgins 1969; Hasselmann 1971; Garrett and Smith 1976; and many others). In particular, Hassel) changes in wave momentum that absorb some of the radiation stress gradients. Garrett and Smith (1976

Smith, Jerome A.

138

Wunderlich, Kaufman, and Smith LINK TRAVEL TIME PREDICTION FOR  

E-print Network

Wunderlich, Kaufman, and Smith 1 LINK TRAVEL TIME PREDICTION FOR DECENTRALIZED ROUTE GUIDANCE@att.com Robert L. Smith University of Michigan Department of Industrial and Operations Engineering Ann Arbor, MI-dating process is utilized to insure the discovery of a stable #12;Wunderlich, Kaufman, and Smith 2 routing after

Smith, Robert L.

139

Tanya M. Smith Department of Human Evolutionary Biology  

E-print Network

1 Tanya M. Smith Department of Human Evolutionary Biology Peabody Museum 47 11 Divinity Avenue, D.J., Larsen, C.S., Hutchinson, D., Smith, T.M. (in review) Chronology of linear enamel hypoplasia.) The Krapina Teeth. Croatian Natural History Museum, Zagreb. #12;2 49. Smith, T.M., Alemseged, Z. (in press

Smith, Tanya M.

140

Tanya M. Smith Department of Human Evolutionary Biology  

E-print Network

1 Tanya M. Smith Department of Human Evolutionary Biology Harvard University 11 Divinity Avenue Foundation Research Grant, 1995. Peer-Reviewed Publications 55. Le Cabec, A., Smith, T.M., Tafforeau, P. (in., Reid, D.J., Larsen, C.S., Hutchinson, D., Smith, T.M. (in review) Chronology of linear enamel

Smith, Tanya M.

141

Deborah K. Smith Department of Geology and Geophysics, MS 22  

E-print Network

Deborah K. Smith Department of Geology and Geophysics, MS 22 Woods Hole Oceanographic Institution: Jordan, T. H., H. W. Menard, and D.K. Smith, Density and size distribution of seamounts in the eastern. Smith, H. W. Menard, J. A. Orcutt and T. H. Jordan, Seismic reflection site survey: correlation

Smith, Deborah K.

142

Mathematics of Games and Politics Instructor: Sam Smith, Mathematics  

E-print Network

Math 132 Mathematics of Games and Politics Syllabus Fall 2010 Instructor: Sam Smith, Mathematics Office Barbelin 212, 610-660-1559, smith@sju.edu Office Hours: Mon 11:30-1:00, Tue 1:00-4:00 or by appointment. Text: Sam Smith, The Mathematics of Games and Politics, available for purchase at the University

Smith, Sam

143

Evolutionary Ecology Research, 2001, 3: 595602 2001 Felisa A. Smith  

E-print Network

Evolutionary Ecology Research, 2001, 3: 595­602 © 2001 Felisa A. Smith Fitness trade-offs select for semelparous reproduction in an extreme environment Felisa A. Smith* and Eric L. Charnov Department of Biology@unm.edu Consult the copyright statement on the inside front cover for non-commercial copying policies. #12;Smith

Smith, Felisa A.

144

Extended Response to Weir and Smith Sven E. Wilson  

E-print Network

Extended Response to Weir and Smith Sven E. Wilson Brigham Young University Benjamin L. Howell University Phone: (801) 422-9018 Email: sven@byu.edu #12;2 Abstract Evidence provided by Weir and Smith and a variety of regression models (including that of Weir and Smith). In particular, our pooled regression

Martinez, Tony R.

145

Using Gazetteers in Discriminative Information Extraction Andrew Smith  

E-print Network

Using Gazetteers in Discriminative Information Extraction Andrew Smith Division of Informatics University of Edinburgh United Kingdom a.p.smith-2@sms.ed.ac.uk Miles Osborne Division of Informatics model, then decoding using a logarithmic opinion pool (Smith et al., 2005), we may achieve much higher

Osborne, Miles

146

Generating and Interpreting Referring Expressions in Dustin Arthur Smith  

E-print Network

Generating and Interpreting Referring Expressions in Context by Dustin Arthur Smith B.S., Wake Referring Expressions in Context by Dustin Arthur Smith Submitted to the Program of Media Arts and Sciences, MIT Media Lab #12;Generating and Interpreting Referring Expressions in Context by Dustin Arthur Smith

147

EIGENVALUES AND THE SMITH NORMAL FORM Joseph J. Rushanan  

E-print Network

EIGENVALUES AND THE SMITH NORMAL FORM Joseph J. Rushanan The MITRE Corporation, M/S E025, Bedford, MA 01730 Abstract. Results are shown that compare the Smith Normal Form (SNF) over the integers and its Smith Normal Form (SNF) over the integers. Our goals are more general than those results

Rushanan, Joe J.

148

Computation of Hermite and Smith Normal Forms of Matrices  

E-print Network

Computation of Hermite and Smith Normal Forms of Matrices by Arne Storjohann A thesis presented the problem of computing Hermite and Smith normal forms of ma­ trices over principal ideal domains. The main probabilistic algorithm to compute the Smith normal form of a polynomial matrix for those cases where pre

Storjohann, Arne

149

Smith & Telang/Competing with Free RESEARCH ARTICLE  

E-print Network

Smith & Telang/Competing with Free RESEARCH ARTICLE COMPETING WITH FREE: THE IMPACT OF MOVIE BROADCASTS ON DVD SALES AND INTERNET PIRACY 1 By: Michael D. Smith H. John Heinz III School of Public Policy. 321-338/June 2009 321 #12;Smith & Telang/Competing with Free Introduction "We can't compete with free

Sadeh, Norman M.

150

Computation of Hermite and Smith Normal Forms of Matrices  

E-print Network

Computation of Hermite and Smith Normal Forms of Matrices; Abstract We study the problem of computing Hermite and Smith normal forms of ma- trices over. One first result is a fast Las Vegas probabilistic algorithm to compute the * *Smith normal form

Storjohann, Arne

151

Numerical algorithms for the computation of the Smith normal  

E-print Network

Numerical algorithms for the computation of the Smith normal form of integral matrices C of the Smith normal form of integral matrices are described. More specifically, the com­ pound matrix method of the algorithms. AMS Subject Classification: Primary 65F30, Secondary 15A21, 15A36. Key words and phrases: Smith

Seberry, Jennifer

152

SMITH FARM FROM CEMETERY HILL, LOOKING SOUTHWEST. (This image shows ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

SMITH FARM FROM CEMETERY HILL, LOOKING SOUTHWEST. (This image shows the Smith Farm in the center of Ebey?s Prairie. Ebey?s Landing and the Puget Sound can be seen on the right. Farmers from the Sherman-Bishop Dairy are visible at the bottom left, cutting hay.) - Smith Farm, 399 Ebey Road, Coupeville, Island County, WA

153

J. E. SMITH1, 2 , L. KORSTEN1  

E-print Network

230 J. E. SMITH1, 2 , L. KORSTEN1 AND T. A. S. AVELING2 " Department of Microbiology and Plant of a new anthracnose disease of cowpea (Vigna unguiculata (L.) Walp.) in South Africa (Smith & Aveling. Sunken, necrotic lesions and small black acervuli are visible on the stems (Smith & Aveling, 1997). Three

154

Tanya M. Smith Department of Human Evolutionary Biology  

E-print Network

1 Tanya M. Smith Department of Human Evolutionary Biology Harvard University 11 Divinity Avenue-Reviewed Publications 53. Carter, K.C., Worthington, S., Smith, T.M. (in review) Molar proportions and third molar agenesis in primates. Evolution 52. Smith, T.M. (in press) Teeth and human life history evolution. An. Rev

Gunawardena, Jeremy

155

Michael Smith Compiled by Christopher Hives (2001, 2005)  

E-print Network

Michael Smith fonds Compiled by Christopher Hives (2001, 2005) University of British Columbia File List Catalogue entry (UBC Library catalogue) #12;Fonds Description Michael Smith fonds. ­ 1957 University of British Columbia faculty member and Nobel prize winner Michael Smith (1932-2000) was born

Handy, Todd C.

156

Friday March 8th, 2013 Michael Smith Building  

E-print Network

Friday March 8th, 2013 9am to 3pm Michael Smith Building (main floor) 2185 East Mall UBC Register Online! bioteach.ubc.ca The Michael Smith Laboratories are pleased to announce a one day Scientific Smith Labs. We can accommodate up to 100 students and registration is free of charge. To enroll, please

Handy, Todd C.

157

an interview with Richard Alba Extraordinary Lives: Patti Smith  

E-print Network

When racial boundaries fade an interview with Richard Alba Extraordinary Lives: Patti Smith What on the workforce, the family, and American society. EXTRAORDINARY LIVES: PATTI SMITH 12 This was the first featured the maximally talented Patti Smith--singer, songwriter, artist and poet--who spoke thoughtfully

Dennehy, John

158

Petition of Nancy Smith for Clemency OHIO PAROLE BOARD  

E-print Network

Petition of Nancy Smith for Clemency OHIO PAROLE BOARD APPLICATION AND MEMORANDUM IN SUPPORT, Justin Sommers, Davis Polk & Wardwell LLP CC: Dennis Will, Lorain County Prosecutor Re: Nancy Smith Date respectfully to urge the grant of a pardon, or alternatively a commutation of sentence, to Nancy Smith, a woman

Papautsky, Ian

159

Marjorie V. Smith Compiled by Margot St. Louis (1979)  

E-print Network

Marjorie V. Smith fonds Compiled by Margot St. Louis (1979) Revised by Erwin Wodarczak (2004 Catalogue entry (UBC Library catalogue) #12; Fonds Description Marjorie V. Smith fonds. ­ 19581973 Marjorie V. Smith was the program director for the Aging and Human Relations Division at UBC's Centre

Handy, Todd C.

160

Embodied Attention and Word Learning by Toddlers Linda B. Smith  

E-print Network

1 Embodied Attention and Word Learning by Toddlers Chen Yu Linda B. Smith Department, & Tenenbaum, 2009; Quine, 1964; Smith & Yu, 2008; Snedeker & Gleitman, 2004; Waxman & Booth, 2001 mechanisms that evaluate data across many word-scene experiences (Frank et al., 2009; Smith & Yu, 2008; Yu

Yu, Chen

161

Dorothy Blakey Smith Compiled by April Haddad (1980)  

E-print Network

Dorothy Blakey Smith fonds Compiled by April Haddad (1980) Last revised October 2012 University (UBC Library catalogue) #12;Fonds Description Dorothy Blakey Smith fonds. ­ 1919-1978. 72 cm of textual records. 78 photographs. Biographical Sketch Born in Leeds, England, Dorothy Blakey Smith immigrated

Handy, Todd C.

162

Wednesday, December 10 4:00 Rebecca Rideout (Bruce Smith)  

E-print Network

Wednesday, December 10 4:00 Rebecca Rideout (Bruce Smith) What's for Dinner? The effect of mite (Bruce Smith) The influence of light polarization on photopositive response of zooplankton 4:30 Drew Bradshaw (Andy Smith) SUMMER RESEARCH PROJECT Effects of oxidation in glue protein 4:45 ­ 5:15 Caitlin

163

Adam Smith, Stoicism and religion in the 18th century  

Microsoft Academic Search

This article explores the influence of Stoicism and religion on Adam Smith. While other commentators have argued either that the main influence on Smith was Stoicism or that it was religion, the two influences have not been explicitly linked. In this article I attempt to make such a link, arguing that Smith can be seen as belonging to the strand

P. H. Clarke

2000-01-01

164

Smith Normal Form a possible basis for an  

E-print Network

Smith Normal Form ­ a possible basis for an SVD ­ like code construction? (Semester Project I) Name.7 The Smith Normal Form . . . . . . . . . . . . . . . . . . . . . . . 12 3 Detailed treatment of the possibilities to use Smith's Normal Form for coding 14 3.1 Introduction

Henkel, Werner

165

THE BREEDING BIOLOGY OF SMITH'S LONGSPUR  

Microsoft Academic Search

INCE 1930, when the railroad connecting the Canadian prairies with the port of Churchill, Manitoba, on Hudson Bay, was completed, the Churchill area has been the scene of many ornithological investigations. Despite this, many of the region's most interesting birds have remained virtually unstudied. One of these is Smith's Longspur (Calcarius pictus) . Our present knowledge of this species on

JOSEPH R. JEIIL. JR

166

Another Perspective: An Interview with David Smith  

ERIC Educational Resources Information Center

To provide another perspective on evaluation within nonformal settings, "New Directions for Evaluation" recently interviewed David Smith, the coordinator of the Professional Learning to Close the Achievement Gap program for the Kansas City, Kansas, Public Schools, who has extensive background in education and educational research. He formerly held…

Bowman, Ruth A.; Johnson, Kelli

2005-01-01

167

Immunological Memory is Associative Derek J. Smith  

E-print Network

Immunological Memory is Associative Derek J. Smith Department of Computer Science University of New Laboratory Los Alamos, NM 87545, USA asp@t10.lanl.gov Abstract This paper argues that immunological memory population in the immune system). Keywords: Immunological Memory, Associative Memory, Cross-Reactive Memory

Somayaji, Anil

168

Adam Smith, Religion, and Tuition Tax Credits.  

ERIC Educational Resources Information Center

Examines tuition tax credit programs in framework of Adam Smith's ideas on the economic impact of established churches. Finds that tuition tax credits would amount to state expenditures to relieve the financial burden of parochial school parents and would allow churches to invest commercially to maintain their charitable functions. (JW)

Alexander, Kern

1983-01-01

169

Dialogues with Marilyn Cochran-Smith  

ERIC Educational Resources Information Center

For more than 30 years, Dr. Marilyn Cochran-Smith has developed and directed research and contributed to publications about education and "practitioner research," especially about teachers' research and learning in inquiry communities. Her primary topics are inquiry communities, teacher research, teacher education for social…

Fiorentini, Dario; Crecci, Vanessa Moreira

2015-01-01

170

Jason Owen-Smith Associate Professor  

E-print Network

Cell Research Goes Global." Stem Cell Reviews and Reports Doi: 10.1007/s12015-012-9391-6. 2011 Scott Trajectories in Pluripotent Stem Cell Research." Cell. 145(6): 820-826. 2011 Owen-Smith, Jason. "The, University Re- search Commercialization, Regional Economic Development, Science Policy, Stem Cells, Collabo

Edwards, Paul N.

171

The Old, Old, Very Old Charlie Smith.  

ERIC Educational Resources Information Center

Widespread claims of extraordinary longevity continue to receive widespread publicity even in first-rate publications. The story of Charlie Smith is reasonably typical of such cultural apocrypha. Development of chemical methods of determining biologic longevity promises to end what often has been heralded as evidence of national distinction.…

Freeman, Joseph T.

1982-01-01

172

Julian Smith: scientific surgeon, photographer, inventor.  

PubMed

Julian Augustus Romaine Smith was one of the surgeons who, in the company of Thomas Dunhill, Hugh Devine, Douglas Shields and David Murray Morton, established Saint Vincent's Hospital, Melbourne, as arguably the premier surgical hospital in Victoria, if not Australia. Smith abandoned a most promising scientific career to study medicine, completing his medical course in Melbourne where he graduated top of his year in 1898/1899. He gained his MD in 1901 and set up practice in Morwell, a Victorian country town, where he initiated his surgical career. In 1905 Smith returned to Melbourne and worked as assistant to Mr F. D. Bird, a prominent surgeon. He travelled overseas in 1906, visiting leading medical centres in England where Almroth Wright's work on vaccination made a deep impression on him. On his return to Australia in 1908 he joined the surgical staff at Saint Vincent's Hospital as surgeon to outpatients, finally retiring as surgeon to inpatients in 1928. Smith was made a Foundation Fellow of the Australasian College of Surgeons in 1927. Smith was regarded by his peers as a brilliant innovative surgeon with a special interest in urology. He became an expert cystoscopist. After he retired, he continued his long-standing interest in portrait photography for which he was considered a master. During World War II he designed and built an elegant roller pump for use in direct blood transfusion. He died in 1947, survived by his wife, a daughter and three sons, one of whom became President of the Royal Australasian College of Surgeons. PMID:11906425

Vellar, Ivo D

2002-01-01

173

Rodney K. Smith Award The Rodney K. Smith Award is the highest service award given by the Dean of The University of  

E-print Network

Rodney K. Smith Award The Rodney K. Smith Award is the highest service award given by the Dean of time in one year. Dean Kevin H. Smith explains, "Professor Rodney Smith was a colleague of mine.e., assisting with a visa application or preventing human trafficking). I believe Professor Smith would find

Dasgupta, Dipankar

174

The Smith-Lemli-Opitz syndrome  

PubMed Central

The Smith-Lemli-Opitz syndrome (SLOS) is one of the archetypical multiple congenital malformation syndromes. The recent discovery of the biochemical cause of SLOS and the subsequent redefinition of SLOS as an inborn error of cholesterol metabolism have led to important new treatment possibilities for affected patients. Moreover, the recent recognition of the important role of cholesterol in vertebrate embryogenesis, especially with regard to the hedgehog embryonic signalling pathway and its effects on the expression of homeobox genes, has provided an explanation for the abnormal morphogenesis in the syndrome. The well known role of cholesterol in the formation of steroid hormones has also provided a possible explanation for the abnormal behavioural characteristics of SLOS.???Keywords: Smith-Lemli-Opitz syndrome; cholesterol metabolism; 7-dehydrocholesterol reductase; clinical history; management PMID:10807690

Kelley, R.; Hennekam, R.

2000-01-01

175

Roger E. Smith: 1986 Horton Award Recipient  

NASA Astrophysics Data System (ADS)

The recipient of the 1986 Robert T. Horton Award is Roger E. Smith. Roger received his bachelor's degree in civil engineering from Texas Technical University at Lubbock, Tex., in 1963, and his master's degree in civil engineering from Stanford University at Stanford, Calif., in 1964. Roger then spent 2 years in the Peace Corps Service in Pakistan. In 1967, he enrolled as a graduate student at Colorado State University.

Johnson, A. Ivan; Smith, Roger E.

176

The Smith Cloud: Galactic or Extragalactic?  

NASA Astrophysics Data System (ADS)

The Milky Way is surrounded by a population of gaseous high-velocity clouds (HVCs), which play an important role in bringing fresh fuel for star formation into the disk. The Smith Cloud is an HVC in an advanced state of accretion, only ~30 Myr away from impacting the Galactic plane. It is unique among HVCs in having a known distance (12.4 kpc) and a well-constrained 3D velocity (300 km/s), but we do not yet know its metallicity, which would distinguish between Galactic (metal-enriched) and extragalactic (metal-poor) origins. Here we propose a program to measure the Smith Cloud's metallicity using HST/COS spectra of three AGN lying behind the Cloud and its wake. Combining the UV metal-line (O I and S II) column densities with existing H I column densities will lead to precise abundance measurements for the Smith Cloud, directly constraining its origin. In addition, the relative strength of depleted (Fe II, Si II) to undepleted (S II) UV absorption lines will be used to infer its dust content. Finally, we will search for variation in the ionization level and kinematics between the three sight lines, which would indicate a disruptive encounter with the hot Galactic corona.

Fox, Andrew

2014-10-01

177

Patent pools and clearinghouses in the life sciences.  

PubMed

The biopharmaceutical industry is slowly absorbing the idea of collaborative patent licensing models. Recently, two patent pools for developing countries have been launched: the Pool for Open Innovation against Neglected Tropical Diseases initiated by GlaxoSmithKline (GSK), which is referred to as the BIO Ventures for Global Health (BVGH) pool, and the Medicines Patent Pool (MPP) initiated by UNITAID. Various organizations have recommended using pools or clearinghouses beyond the humanitarian dimension where many patents are owned by many different actors. As a first attempt, MPEG LA, which administers patent pools in various technology fields, is now setting up a clearinghouse for patents related to molecular diagnostics. These examples as well as the results from an empirical study provide useful insights for the design and administration of future pools and clearinghouses in the life sciences. PMID:21733589

van Zimmeren, Esther; Vanneste, Sven; Matthijs, Gert; Vanhaverbeke, Wim; Van Overwalle, Geertrui

2011-11-01

178

A Divergent SAR Study Allows Optimization of a Potent 5-HT2c Inhibitor to a Promising Antimalarial Scaffold  

PubMed Central

From the 13?533 chemical structures published by GlaxoSmithKline in 2010, we identified 47 quality starting points for lead optimization. One of the most promising hits was the TCMDC-139046, a molecule presenting an indoline core, which is well-known for its anxiolytic properties by interacting with serotonin antagonist receptors 5-HT2. The inhibition of this target will complicate the clinical development of these compounds as antimalarials. Herein, we present the antimalarial profile of this series and our efforts to avoid interaction with this receptor, while maintaining a good antiparasitic potency. By using a double-divergent structure–activity relationship analysis, we have obtained a novel lead compound harboring an indoline core. PMID:24900481

2012-01-01

179

A Divergent SAR Study Allows Optimization of a Potent 5-HT2c Inhibitor to a Promising Antimalarial Scaffold.  

PubMed

From the 13?533 chemical structures published by GlaxoSmithKline in 2010, we identified 47 quality starting points for lead optimization. One of the most promising hits was the TCMDC-139046, a molecule presenting an indoline core, which is well-known for its anxiolytic properties by interacting with serotonin antagonist receptors 5-HT2. The inhibition of this target will complicate the clinical development of these compounds as antimalarials. Herein, we present the antimalarial profile of this series and our efforts to avoid interaction with this receptor, while maintaining a good antiparasitic potency. By using a double-divergent structure-activity relationship analysis, we have obtained a novel lead compound harboring an indoline core. PMID:24900481

Calderón, Félix; Vidal-Mas, Jaume; Burrows, Jeremy; de la Rosa, Juan Carlos; Jiménez-Díaz, María Belén; Mulet, Teresa; Prats, Sara; Solana, Jorge; Witty, Michael; Gamo, Francisco Javier; Fernández, Esther

2012-05-10

180

Strategies for continuous evaluation of the benefit-risk profile of HPV-16/18-AS04-adjuvanted vaccine.  

PubMed

The HPV types 16/18-AS04-adjuvanted cervical cancer vaccine, Cervarix(®) (HPV-16/18-vaccine, GlaxoSmithKline, Belgium) was first approved in 2007 and is licensed in 134 countries for the prevention of persistent infection, premalignant cervical lesions and cervical cancer caused by oncogenic HPV. Benefit-risk status requires continual re-evaluation as vaccine uptake increases, as the epidemiology of the disease evolves and as new information becomes available. This paper provides an example of benefit-risk considerations and risk-management planning. Evaluation of the benefit-risk of HPV-16/18-vaccine post-licensure includes studies with a range of designs in many countries and in collaboration with national public agencies and regulatory authorities. The strategy to assess benefit versus risk will continue to evolve and adapt to the changing HPV-16/18-vaccine market. PMID:25219284

Angelo, Maria-Genalin; Taylor, Sylvia; Struyf, Frank; Tavares Da Silva, Fernanda; Arellano, Felix; David, Marie-Pierre; Dubin, Gary; Rosillon, Dominique; Baril, Laurence

2014-11-01

181

Pooled analysis of safety data from pediatric Phase II RTS,S/AS malaria candidate vaccine trials.  

PubMed

Prior to progression to Clinical Development Phase III, GlaxoSmithKline Biologicals performed a pooled analysis of phase two safety data following administration of 8860 doses of RTS,S/AS to 2981 children under 5 years old. RTS,S/AS was associated with increased rates of non-serious URTI, rash and diaper dermatitis graded mild or moderate. There was no significant increased rate of overall or single SAEs. Two episodes of simple febrile seizure were estimated to be related to vaccination. Significant decreased relative risks of death, any SAE, any SAE excluding malaria and pneumonia were observed. The results suggest a favourable risk-benefit balance which is to be confirmed in the ongoing Phase III trials. PMID:22108035

Vekemans, Johan; Guerra, Yolanda; Lievens, Marc; Benns, Sarah; Lapierre, Didier; Leach, Amanda; Verstraeten, Thomas

2011-12-01

182

Pharmaceutical industry, academia and patient advocacy organizations: What is the recipe for synergic (win-win-win) collaborations?  

PubMed

Biological complexity and the need for highly differentiated medicines means that drug discovery and development have become increasingly challenging and expensive. Thus, new paradigms for research and drug development need to be created that bring together a wide array of expertise. One potential solution is collaboration between bio-pharma and academic research centres. Two examples are discussed, one with a large pharma company (GlaxoSmithKline) and the other a small biotech (Genoa Pharmaceuticals). Patient advocacy organization can also have role in assisting in the creation of these partnerships by informing patients of ongoing research and clinical trials, and supporting the development of networks that can provide major benefit for both basic research and drug development. A major 'hurdle' for the creation of these relationships is the issue of intellectual property. Examples are provided of how this issue can be resolved. PMID:25580960

Rose, Daniel M; Marshall, Richard; Surber, Mark W

2015-02-01

183

Obtaining real-world evidence: the Salford Lung Study  

PubMed Central

We need to assess clinical treatments in real-life settings outside of randomised controlled trials (RCTs). Pragmatic RCT (pRCT) data can supplement RCTs by providing effectiveness information to support healthcare decisions. Electronic health records can facilitate concurrent safety monitoring and data collection without direct patient contact for large randomised study populations in pRCTs. The Salford Lung Study is the world's first phase III pRCT in asthma and chronic obstructive pulmonary disease (COPD), which aims to randomise over 7000 patients. This paper describes the hurdles overcome and the enormous effort and resource required to establish this comparative effectiveness study of a prelicence intervention. GlaxoSmithKline protocol HZC115151 Asthma study clinicaltrials.gov registration NCT01706198 COPD study clinicaltrials.gov registration NCT01551758 PMID:24603195

New, John P; Bakerly, Nawar Diar; Leather, David; Woodcock, Ashley

2014-01-01

184

Theodate Smith and Amy Tanner: child savers of Clark University.  

PubMed

This study is an examination of the contributions of Theodate Smith and Amy Tanner to the Children's Institute of Clark University. The institute, established in 1909 by Clark's president, G. Stanley Hall, failed to thrive as a liaison between child study and child welfare concerns for a number of reasons, including Hall's eventual disenchantment with the child welfare movement, financial difficulties, and the loss by the institute of Smith and Tanner. Both Smith and Tanner, unlike Hall, were sympathetic to child welfare concerns. Thus, Smith's death in 1914 and Tanner's departure from Clark in 1918 severed the links between the institute and child welfare interests. PMID:1797978

Diehl, L A

1991-09-01

185

Trois bicentenaires : Hume, Condillac, Smith. Adam Smith entre le marginalisme et le marxisme  

Microsoft Academic Search

It is not easy to understand why, and how, orthodox economists who do not believe either in the labor-theory or in the cost-theory of value, continue to favor Adam Smith's Wealth of Nations, but forget such economists as Condillac, whose value theory is nearer to theirs and whose bicentenary we also commemorate.

Gérard R. Pelletier

1977-01-01

186

Smith Newton Vehicle Performance Evaluation - Cumulative (Brochure)  

SciTech Connect

The Fleet Test and Evaluation Team at the U.S. Department of Energy's National Renewable Energy Laboratory is evaluating and documenting the performance of electric and plug-in hybrid electric drive systems in medium-duty trucks across the nation. U.S. companies participating in this evaluation project received funding from the American Recovery and Reinvestment Act to cover part of the cost of purchasing these vehicles. Through this project, Smith Electric Vehicles is building and deploying 500 all-electric medium-duty trucks that will be deployed by a variety of companies in diverse climates across the country.

Not Available

2014-08-01

187

Rodney K. Smith Award The Rodney K. Smith Award is the highest service award given by the Dean of the University of  

E-print Network

Rodney K. Smith Award The Rodney K. Smith Award is the highest service award given by the Dean. Humphreys School of Law, Rodney K. Smith's interest in, and respect for, public service was not limited trafficking). Interim Dean William P. Kratzke explains, "I knew Professor Rodney Smith when he was a faculty

Memphis, University of

188

78 FR 23845 - Drawbridge Operation Regulations; Narrow Bay, Smith Point, NY  

Federal Register 2010, 2011, 2012, 2013

...The deviation is necessary to facilitate the Smith Point Triathlon. This deviation allows the bridge to remain closed for two...facilitate public safety during a public event, the Smith Point Triathlon. Under this temporary deviation the Smith Point...

2013-04-23

189

THE LEAHY-SMITH AMERICA INVENTS ACT INTRODUCTION  

E-print Network

TOPIC: THE LEAHY-SMITH AMERICA INVENTS ACT INTRODUCTION: In 2004, a committee of the National. [1] After seven years of debate among the major stakeholders, the Leahy-Smith America Invents Act reforms. This NACUANOTE summarizes the main changes under the AIA and offers some initial commentary

190

Evolutionary Ecology Research, 2001, 3: 331344 2001 Adam R. Smith  

E-print Network

Evolutionary Ecology Research, 2001, 3: 331­344 © 2001 Adam R. Smith Correlated evolution of colony defence and social structure: A comparative analysis in eusocial wasps (Hymenoptera: Vespidae) Adam R. Smith,1 * Sean O'Donnell1 and Robert L. Jeanne2 1 Animal Behavior Area, Department of Psychology

O'Donnell, Sean

191

experiment actually sees," Smith says. "When we were  

E-print Network

experiment actually sees," Smith says. "When we were finished, we got much more ­ a method that could also tell us which other experiments should be done to see all the other motions present in science depend on atoms and molecules moving," Smith says. "We want to create movies of molecules

Pennycook, Steve

192

(Mis)Representing Underachievement: A Rejoinder to Gorard and Smith  

ERIC Educational Resources Information Center

This article provides a brief rejoinder to Gorard and Smith's reply to an article I published in a previous issue of British Journal of Sociology of Education. In that original article I provided a critical review of their quantitative research on gender and education in the United Kingdom. In their reply to this article, Gorard and Smith seem to…

Connolly, Paul

2008-01-01

193

Oscar F. Smith Middle School: One Extra Degree  

ERIC Educational Resources Information Center

This article features Oscar F. Smith Middle School, a challenging school in Chesapeake, Virginia. When Principal Linda Scott exclaims, "Oscar F. Smith Middle School is "hot"!" to visitors, she is not referring to the inside temperature of the bustling school of grades 6-8 located in the historic South Norfolk borough of Chesapeake. She is…

Principal Leadership, 2012

2012-01-01

194

Father Knows Best: Using Adam Smith to Teach Transactions Costs  

ERIC Educational Resources Information Center

Adam Smith's moral philosophy can be used to introduce economics students to the important idea of transactions costs. The author provides a brief background in this article to Smith's moral philosophy and connects it to the costs of transacting in a way that fits easily into the standard principles of microeconomics classroom. By doing…

Dupont, Brandon

2014-01-01

195

Author! Author! The Gallant Children's Author: Dick King-Smith  

ERIC Educational Resources Information Center

This column presents a brief biography of Dick King-Smith. Born on March 27, 1922 and raised in Gloucestershire, England, he grew up with animals of all kinds. King-Smith was a farmer for twenty years and then became a school teacher. He was also a soldier during wartime, a traveling salesman, shoe factory worker, and television presenter. He…

Brodie, Carolyn S.

2005-01-01

196

Mark Smith KTH School of ICT IS2500: RFID Systems  

E-print Network

Mark Smith KTH School of ICT IS2500: RFID Systems RFID stands for Radio Frequency Identification and verification RFID is pervasive. It is growing as a business and information tool. You may be carrying many RFID devices with you right now. #12;Mark Smith KTH School of ICT RFID is a big business It is very significant

Maguire Jr., Gerald Q.

197

1. VIEW OF THE SMITH NO. 3 SITE AREA TO ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. VIEW OF THE SMITH NO. 3 SITE AREA TO THE NORTHWEST. THE MINE OFFICE BUILDING IS IN THE FOREGROUND AND THE TIPPLE AND PROCESSING PLANT ARE IN THE BACKGROUND. - Smith Mine, Bear Creek 1.5 miles West of Town of Bear Creek, Red Lodge, Carbon County, MT

198

Adam Smith on the Nature and Causes of Poverty  

Microsoft Academic Search

Adam Smith's views on poverty have received less attention than one would expect, but they are worth examining. In the Moral Sentiments Smith takes a skeptical, ironic view of the striving for material goods and wealth. Poverty is treated not as a condition of economic deprivation but as a cause of social isolation and psychic unease. In the Lectures on

Geoffrey Gilbert

1997-01-01

199

Environmental assessment overview, Deaf Smith County site, Texas  

SciTech Connect

In February 1983, the US Department of Energy (DOE) identified a location in Deaf Smith County, Texas, as one of nine potentially acceptable sites for mined geologic repository for spent nuclear fuel and high-level radioactive waste. To determine their suitability, the Deaf Smith County site and eight other potentially acceptable sites have been evaluated in accordance with the DOE's General Guidelines for the Recommendation of Sites for the Nuclear Waste Repositories. The Deaf Smith County site is in the Permian Basin, which is one of five distinct geohydrologic settings considered for the first repository. On the basis of the evaluations reported in this EA, the DOE has found that the Deaf Smith County site is not disqualified under the guidelines. On the basis of these findings, the DOE is nominating the Deaf Smith County site as one of five sites suitable for characterization. 3 figs.

Not Available

1986-05-01

200

SELECTED PUBLICATIONS -Doug Smith Smith, D., 2010, Antigorite Peridotite, Metaserpentinite, and other Inclusions within Diatremes on the  

E-print Network

Plateau, Southwestern United States. Journal of Petrology, v 46, 1901-1924. Smith D., Connelly J. N. (Joe) Boyd. Eds. Fei, Y., Bertka, C. M., and Mysen, B. O., Geochemical Society Special Publication no. 6, 171-188. Smith, D. and Riter, J. C. A., 1997, Genesis and evolution of low-Al orthopyroxene

Yang, Zong-Liang

201

Trinucleotide repeat expansion and DRPLA (Smith`s disease): Molecular characterization of atrophin-1  

SciTech Connect

Smith`s disease (also known as dentatorubral pallidoluysian atrophy or DRPLA) is a rare, progressive, fatal neuropsychiatric disorder similar to Huntington`s disease (HD). Smith`s disease is characterized by ataxia, choreoathetosis, myoclonic epilepsy, dementia, and genetic anticipation. Neuropathological findings include prominent cell loss in the dentate nucleus of the cerebellum, the globus pallidus, the red nucleus, and the subthalamic nucleus. An expansion of a CAG trinucleotide repeat encoding polyglutamine in a gene originally identified in our laboratory as part of a program to clone candidate genes for disorders with anticipation has recently been found to cause this disorder. We have identified two families that demonstrate the pathological and genetic features (expanded CAG repeat and anticipation) of this disease. Northern analysis indicates that the gene, which we have termed atrophin-1, is widely expressed as a 5 kb mRNA in normal human brain and peripheral tissues. Brain expression is highest in the cerebellum. The developmental expression of the rat homologues of IT-15 (the gene in which a CAG expansion causes HD) and atrophin-1 were compared. Atrophin-1 was most highly expressed in early rat embryo brain (E16), whereas the greatest expression of IT-15 was in the adult rat brain. Cloning and sequencing of the open reading frame from inserts contained in brain cDNA libraries is in progress. In addition to the CAG repeat, the ORF contains an unusual region of alternating acidic and basic amino acids. Further characterization of atrophin-1, and comparison of it to other genes in which trinucleotide repeat expansion leads to neuropsychiatric disorders, should lead to a better understanding of the pathophysiology by which CAG repeat expansion causes human disease.

Margolis, R.L.; Li, S.H.; Li, X.J.; Ross, C.A. [Johns Hopkins Univ., Balitmore, MD (United States)

1994-09-01

202

Antifungal saponins from Paris polyphylla Smith.  

PubMed

Three steroidal saponins, including one new and two known compounds, were isolated from the rhizomes of Paris polyphylla Smith. One- and two-dimensional NMR, LC-MS, and interpretation of hydrolytic cleavage experiments led to the identification of the structure of the new saponin as ( 25R)-spirost-5-ene-3 beta,17 alpha-diol (pennogenin) 3- O-{ O- alpha- L-rhamnopyranosyl-(1-->2)- O-[ O- beta-xylopyranosyl-(1-->5)- alpha- L-arabinofuranosyl-(1-->4)]- beta- D-glucopyranoside}. The isolated saponins were evaluated for their antifungal activity against Cladosporium cladosporioides and Candida species and showed comparable activity to chemicals used in some commercial products. PMID:18729041

Deng, Dawei; Lauren, Denis R; Cooney, Janine M; Jensen, Dwayne J; Wurms, Kirstin V; Upritchard, Jenine E; Cannon, Richard D; Wang, Ming Zhong; Li, Ming Zhang

2008-09-01

203

Sophia Smith Collection: Voices of Feminism  

NSDL National Science Digital Library

Based at Smith College, the Voices of Feminism Oral History Project "documents the persistence and diversity of organizing for women in the United States in the latter half of the 20th century." The women interviewed here include labor, peace, and anti-racism activists, along with anti-poverty organizers and lesbian rights advocates. The project was funded by the Ford Foundation from 2002 to 2008, and visitors will find that they can also read transcripts of the interviews as well. The "Narrators" page features biographical profiles of each interviewee, along with links to the transcript of each interview. As a bonus feature, there are video excerpts for six of the women interviewed as part of the project.

204

THE ROSENZWEIG-MACARTHUR PREDATOR-PREY HAL L. SMITH*  

E-print Network

THE ROSENZWEIG-MACARTHUR PREDATOR-PREY MODEL HAL L. SMITH* SCHOOL OF MATHEMATICAL AND STATISTICAL. It is the per predator kill rate. 1 #12;2 H.L. Smith 0 0.5 1 1.5 2 2.5 3 3.5 0 0.2 0.4 0.6 0.8 1 1.2 1.4 1.6 1 that solutions are bounded in the future and therefore are defined for all t 0. #12;4 H.L. Smith Notice that 2

Smith, Hal

205

STS-82 Mission Specialist Steven L. Smith Suit Up  

NASA Technical Reports Server (NTRS)

STS-82 Mission Specialist Steven L. Smith gives a ''';thumbs up'''; while donning his launch and entry suit in the Operations and Checkout Building. A suit technician stands ready to assist with final adjustments. This is Smith''';s second space flight. He and the six other crew members will depart shortly for Launch Pad 39A, where the Space Shuttle Discovery awaits liftoff on a 10-day mission to service the orbiting Hubble Space Telescope (HST). This will be the second HST servicing mission. Four back-to-back spacewalks are planned.

1997-01-01

206

The Compositional Evolution of the Murid Genome Nick G.C. Smith,1  

E-print Network

The Compositional Evolution of the Murid Genome Nick G.C. Smith,1 Adam Eyre-Walker2 1 Department-Walker 1999; Smith and Eyre- Walker 2001). Given that the GC content of protein- coding genes is highly polymorphism data fromCorrespondence to: Nick Smith; email: nick.smith@ebc.uu.se J Mol Evol (2002) 55

Eyre-Walker, Adam

207

Laurie Brban and Andr Lapidus Adam Smith on Lotteries 01.12.2013 13:42  

E-print Network

Laurie Bréban and André Lapidus ­ Adam Smith on Lotteries 01.12.2013 13:42 1 ADAM SMITH The few pages that Adam Smith devoted to lotteries, mainly in the Wealth of Nations (1776) did not receive transformed into risk-aversion. Keywords: Adam Smith, decision, risk, lotteries, stochastic dominance, rank

Paris-Sud XI, Université de

208

16. SMITH POINT BRIDGE ON OLD HIGHWAY 101. SOUTH OF ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

16. SMITH POINT BRIDGE ON OLD HIGHWAY 101. SOUTH OF GARBERVILLE, HUMBOLDT COUNTY, CALIFORNIA. LOOKING NNE. - Redwood National & State Parks Roads, California coast from Crescent City to Trinidad, Crescent City, Del Norte County, CA

209

VIEW OF HOWLAND HILL ROAD, JEDEDIAH SMITH STATE PARK. CRESCENT ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

VIEW OF HOWLAND HILL ROAD, JEDEDIAH SMITH STATE PARK. CRESCENT CITY, DEL NORTE COUNTY, CALIFORNIA. LOOKING E. - Redwood National & State Parks Roads, California coast from Crescent City to Trinidad, Crescent City, Del Norte County, CA

210

MORTALITY ESTIMATES FROM SIZE DISTRIBUTIONS: A CRITIQUE OF SMITH'S MODEL  

EPA Science Inventory

Smith (1972) described a method of computing mortality rates from growth and size-frequency data for a population which meets several assumptions. (Copyright (c) 1977 by The American Society of Limnology and Oceanography, Inc.)...

211

STS-82 M.S. Steven Smith in White Room  

NASA Technical Reports Server (NTRS)

STS-82 Mission Specialist Steven L. Smith prepares to enter the Space Shuttle Discovery at Launch Pad 39A, with the assistance of white room closeout crew members Dave Law, in front; Carlous Gillis, at left; and James Davis.

1997-01-01

212

20. Photocopy of photograph (From Frances Rand Smith Collection, California ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

20. Photocopy of photograph (From Frances Rand Smith Collection, California Historical Society) Photographer unknown, Date unknown VIEW OF CHURCH FROM REAR - Mission San Miguel Arcangel, Highway 101, San Miguel, San Luis Obispo County, CA

213

16. Photocopy of photograph (from Frances Rand Smith Collection, California ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

16. Photocopy of photograph (from Frances Rand Smith Collection, California Historical Society, 1900) Photographer unknown, Date unknown FRONT VIEW OF MISSION, c. 1900 - Mission San Miguel Arcangel, Highway 101, San Miguel, San Luis Obispo County, CA

214

Longitudinal profile monitors using Coherent Smith-Purcell radiation  

NASA Astrophysics Data System (ADS)

Coherent Smith-Purcell radiation has the potential of providing information on the longitudinal profile of an electron bunch. The E-203 experiment at the FACET User Facility measures bunch profiles from the SLAC linac in the hundreds of femtoseconds range and the SPESO collaboration at Synchrotron SOLEIL is planning to make an accurate 2D map of the Coherent Smith-Purcell Radiation emission.

Andrews, H. L.; Bakkali Taheri, F.; Barros, J.; Bartolini, R.; Cassinari, L.; Clarke, C.; Le Corre, S.; Delerue, N.; Doucas, G.; Fuster-Martinez, N.; Konoplev, I.; Labat, M.; Perry, C.; Reichold, A.; Stevenson, S.; Vieille Grosjean, M.

2014-03-01

215

STS-82 Mission Specialist Steven L. Smith during TCDT  

NASA Technical Reports Server (NTRS)

STS-82 Mission Specialist Steven L. Smith adjusts the glove of his launch and entry space suit during a practice countdown at KSC. Smith and the other six STS-82 crew members are at KSC to participate in the Terminal Countdown Demonstration Test (TCDT), a dress rehearsal for launch. STS-82 will be the second Hubble Space Telescope servicing mission. Liftoff is targeted for February 11.

1997-01-01

216

School in photodermatology: Smith-Lemli-Opitz syndrome.  

PubMed

The Smith-Lemli-Opitz syndrome has only recently been added to the small number of congenital disorders characterized by photosensitivity. The clinical features of this disorder are distinct from other photosensitivity syndromes. Details on the patho-mechanism of photosensitivity in the Smith-Lemli-Opitz syndrome have yet to be fully determined. However, preliminary evidence points to the deranged cholesterol metabolism that characterizes the syndrome as causal in this UVA-mediated photosensitivity disorder. PMID:16869869

Anstey, Alex

2006-08-01

217

Kiki Smith: Prints, Books & Things at MoMA  

NSDL National Science Digital Library

Using a similar interface to that of Artists of Brücke (German Expressionist prints, reviewed in the December 5, 2003 and Nov.2, 2001 Scout Reports), the Museum of Modern Art (MoMA) presents this major retrospective of the work of Kiki Smith, born in 1954 in Nuremberg, Germany. Smith is the daughter of American sculptor Tony Smith, and her first experience with art was helping her father make cardboard models for his geometric sculptures. She is thought of as a sculptor and builder of installations, but since the 1980s, has created an extensive body of printed works, 135 of which are gathered in this web exhibition. Like the Expressionist show, the Smith show features a virtual light table of images that can be arranged dynamically by Themes -- early screen prints, anatomy, self-portraits, nature, feminine contexts -- or Mediums. In recent years, Smith has worked on etchings pulled from plates of monumental size, roughly 4 feet by 6 feet, such as a series based on Lewis Carroll, including Pool of Tears 2 (2000) and Come Away from Her (2003). The site also includes a chronology of Smith's life and a 35-page essay by Wendy Weitman, MoMA's Curator of Prints and illustrated Books.

218

Edwin Smith Papyrus Case 8: a reappraisal.  

PubMed

There are 3 translations of the Edwin Smith Papyrus: Breasted's (1930), Allen's (2005), and Sanchez and Meltzer's (2012). Case 8 is similarly presented in all 3 translations, although with increasing detail in the later works. The patient in Case 8 had a comminuted skull fracture under intact skin. There were palpable pulsations at the fracture site. There was deviation of the eye on the side of the injury and an ipsilateral spastic hemiparesis in an ambulant patient with bleeding from the nose and ear. Explanations of the paralysis have included a contrecoup lesion and compression of the contralateral cerebral peduncle against the tentorial incisura. Brainstem compression due to herniation is accompanied by loss of consciousness. Extensive contrecoup lesions consistent with the extent of the described paresis would also be associated with probable coma. The paralysis was spastic, but spasticity takes weeks to develop after trauma. Yet this patient's trauma was fresh, as there was still bleeding from the nose and the ear. It is suggested the paresis antedated the trauma, which was not its cause. The reasons for this suggestion are presented in this paper. PMID:24484229

Ganz, Jeremy C

2014-05-01

219

MAGNETIZED GAS IN THE SMITH HIGH VELOCITY CLOUD  

SciTech Connect

We report the first detection of magnetic fields associated with the Smith High Velocity Cloud. We use a catalog of Faraday rotation measures toward extragalactic radio sources behind the Smith Cloud, new H I observations from the Robert C. Byrd Green Bank Telescope, and a spectroscopic map of H? from the Wisconsin H-Alpha Mapper Northern Sky Survey. There are enhancements in rotation measure (RM) of ?100 rad m{sup –2} which are generally well correlated with decelerated H? emission. We estimate a lower limit on the line-of-sight component of the field of ?8 ?G along a decelerated filament; this is a lower limit due to our assumptions about the geometry. No RM excess is evident in sightlines dominated by H I or H? at the velocity of the Smith Cloud. The smooth H? morphology of the emission at the Smith Cloud velocity suggests photoionization by the Galactic ionizing radiation field as the dominant ionization mechanism, while the filamentary morphology and high (?1 Rayleigh) H? intensity of the lower-velocity magnetized ionized gas suggests an ionization process associated with shocks due to interaction with the Galactic interstellar medium. The presence of the magnetic field may contribute to the survival of high velocity clouds like the Smith Cloud as they move from the Galactic halo to the disk. We expect these data to provide a test for magnetohydrodynamic simulations of infalling gas.

Hill, Alex S.; McClure-Griffiths, Naomi M. [CSIRO Astronomy and Space Science, Marsfield, NSW (Australia); Mao, S. A. [Department of Astronomy, University of Wisconsin-Madison, Madison, WI (United States); Benjamin, Robert A. [Department of Physics, University of Wisconsin-Whitewater, Whitewater, WI (United States); Lockman, Felix J., E-mail: alex.hill@csiro.au, E-mail: naomi.mcclure-griffiths@csiro.au, E-mail: mao@astro.wisc.edu, E-mail: benjamir@uww.edu, E-mail: jlockman@nrao.edu [National Radio Astronomy Observatory, Green Bank, WV (United States)

2013-11-01

220

Derivation of Asset Price Equations Through Statistical Inference Gunduz Caginalp, Vladimira Ilieva, David Porter and Vernon Smith  

E-print Network

that have also cast doubt on the validity of EMH (Smith, Suchanek and Williams [1988], Porter and Smith, David Porter and Vernon Smith We develop a methodology to extract a quantitative model for behavioral

Ã?aginalp, Gunduz

221

Additional corrections to the Gross-Llewellyn Smith sum rule  

SciTech Connect

We investigate some QCD corrections that contribute to the Gross-Llewellyn Smith sum rule but have not been included in previous analyses of it. We first review the techniques by which the xF{sub 3} structure function is extracted from combinations of neutrino and antineutrino cross sections. Next we investigate corrections to the Gross-Llewellyn Smith sum rule, with particular attention to contributions arising from strange quark distributions and from charge symmetry violating parton distributions. We find that additional corrections from strange quarks and parton charge symmetry violation are likely to have a small but potentially significant role in decreasing the current discrepancy between the experimental and theoretical estimates of the Gross-Llewellyn Smith sum rule.

Londergan, J. T.; Thomas, A. W. [Department of Physics and Center for Exploration of Energy and Matter, Indiana University, Bloomington, Indiana 47405 (United States); CSSM, School of Chemistry and Physics, University of Adelaide, Adelaide SA 5005 (Australia)

2010-12-01

222

SR-71 Pilot Rogers E. Smith  

NASA Technical Reports Server (NTRS)

Research pilot Rogers E. Smith is shown here in front of the SR-71 Blackbird he flew for NASA. Rogers was one of the two original NASA research pilots assigned to the SR-71 high speed research program at NASA's Ames-Dryden Flight Research Facility (later, Dryden Flight Research Center, Edwards, California. Smith has been a NASA research pilot at Dryden since 1982. Data from the SR-71 program will be used to aid designers of future supersonic aircraft and propulsion systems. The SR-71 is capable of flying more than 2200 mph (Mach 3+) and at altitudes of over 80,000 feet. Two SR-71 aircraft have been used by NASA as testbeds for high-speed and high-altitude aeronautical research. The aircraft, an SR-71A and an SR-71B pilot trainer aircraft, have been based here at NASA's Dryden Flight Research Center, Edwards, California. They were transferred to NASA after the U.S. Air Force program was cancelled. As research platforms, the aircraft can cruise at Mach 3 for more than one hour. For thermal experiments, this can produce heat soak temperatures of over 600 degrees Fahrenheit (F). This operating environment makes these aircraft excellent platforms to carry out research and experiments in a variety of areas -- aerodynamics, propulsion, structures, thermal protection materials, high-speed and high-temperature instrumentation, atmospheric studies, and sonic boom characterization. The SR-71 was used in a program to study ways of reducing sonic booms or over pressures that are heard on the ground, much like sharp thunderclaps, when an aircraft exceeds the speed of sound. Data from this Sonic Boom Mitigation Study could eventually lead to aircraft designs that would reduce the 'peak' overpressures of sonic booms and minimize the startling affect they produce on the ground. One of the first major experiments to be flown in the NASA SR-71 program was a laser air data collection system. It used laser light instead of air pressure to produce airspeed and attitude reference data, such as angle of attack and sideslip, which are normally obtained with small tubes and vanes extending into the airstream. One of Dryden's SR-71s was used for the Linear Aerospike Rocket Engine, or LASRE Experiment. Another earlier project consisted of a series of flights using the SR-71 as a science camera platform for NASA's Jet Propulsion Laboratory in Pasadena, California. An upward-looking ultraviolet video camera placed in the SR-71's nosebay studied a variety of celestial objects in wavelengths that are blocked to ground-based astronomers. Earlier in its history, Dryden had a decade of past experience at sustained speeds above Mach 3. Two YF-12A aircraft and an SR-71 designated as a YF-12C were flown at the center between December 1969 and November 1979 in a joint NASA/USAF program to learn more about the capabilities and limitations of high-speed, high-altitude flight. The YF-12As were prototypes of a planned interceptor aircraft based on a design that later evolved into the SR-71 reconnaissance aircraft. Dave Lux was the NASA SR-71 project manger for much of the decade of the 1990s, followed by Steve Schmidt. Developed for the USAF as reconnaissance aircraft more than 30 years ago, SR-71s are still the world's fastest and highest-flying production aircraft. The aircraft can fly at speeds of more than 2,200 miles per hour (Mach 3+, or more than three times the speed of sound) and at altitudes of over 85,000 feet. The Lockheed Skunk Works (now Lockheed Martin) built the original SR-71 aircraft. Each aircraft is 107.4 feet long, has a wingspan of 55.6 feet, and is 18.5 feet high (from the ground to the top of the rudders, when parked). Gross takeoff weight is about 140,000 pounds, including a possible fuel weight of 80,280 pounds. The airframes are built almost entirely of titanium and titanium alloys to withstand heat generated by sustained Mach 3 flight. Aerodynamic control surfaces consist of all-moving vertical tail surfaces, ailerons on the outer wings, and elevators on the trailing edges between the engine exhaust nozzles. The two SR-71s at Dryden ha

1992-01-01

223

CRCHD - CRCHD Research - Principal Investigator: Mary A. Smith, Ph.D., M.S.  

Cancer.gov

Dr. Smith’s research projects focus on bioinformatics analysis of nuclear hormone receptors, with specific emphasis on the peroxisome proliferator-activated receptor and retinoid X receptor proteins, regulation, mechanisms of action and implications for obesity and related diseases.

224

Adaptationism and the adaptive landscape Jon F. Wilkins Peter Godfrey-Smith  

E-print Network

Adaptationism and the adaptive landscape Jon F. Wilkins Ã? Peter Godfrey-Smith Received: 28 October previous forms, which may have J. F. Wilkins Santa Fe Institute, Santa Fe, NM 87501, USA P. Godfrey-Smith

Wilkins, Jon F.

225

The Robert H. Smith Faculty of Agriculture, Food & Environment The Division for External Studies  

E-print Network

The Robert H. Smith Faculty of Agriculture, Food & Environment The Division for External Studies to the age of 35, for a one or two year master's degree at the Robert H. Smith Faculty of Agriculture, Food

Anat, Maril,

226

75 FR 37462 - Official Trail Marker for the Captain John Smith Chesapeake National Historic Trail  

Federal Register 2010, 2011, 2012, 2013

...Service Official Trail Marker for the Captain John Smith Chesapeake National Historic Trail...official trail marker insignias of the Captain John Smith Chesapeake National Historic Trail...The primary author of this document is John Maounis, Superintendent, Captain...

2010-06-29

227

77 FR 58181 - Power Resources, Inc., Smith Ranch Highland Uranium Project; License Renewal Request, Opportunity...  

Federal Register 2010, 2011, 2012, 2013

...Resources, Inc., Smith Ranch Highland Uranium Project; License Renewal Request, Opportunity...referenced. The Smith Ranch Highland Uranium Project license renewal request is available...Mandeville, Senior Project Manager, Uranium Recovery Licensing Branch, Division...

2012-09-19

228

Local Reasoning about Mashups Philippa Gardner, Gareth Smith, and Adam Wright  

E-print Network

Local Reasoning about Mashups Philippa Gardner, Gareth Smith, and Adam Wright Imperial College homepage Lorem ipsum dolor sit amet, Updates Testing.. Adam Wright Proving... Gareth Smith updates... Adam Wright Proving... Gareth Smith Twitter twitter.example.com Web Browser Fig. 1. Twitter mashup

Gardner, Philippa

229

Adam Smith School of Business Management Ltd GUIDE TO INFORMATION AVAILABLE THROUGH OUR PUBLICATION SCHEME  

E-print Network

Adam Smith School of Business Management Ltd GUIDE TO INFORMATION AVAILABLE THROUGH OUR PUBLICATION and what it might cost. Adam Smith School of Business Management Ltd is wholly publicly owned Where Adam Smith School of Business Management Ltd holds the copyright in its published information

Glasgow, University of

230

PLEASE SCROLL DOWN FOR ARTICLE This article was downloaded by: [Smith, Lloyd V.  

E-print Network

PLEASE SCROLL DOWN FOR ARTICLE This article was downloaded by: [Smith, Lloyd V.] On: 21 February and challenges in numerically modelling solid sports balls with application to softballs Lloyd V. Smith, Washington, USA First Published:January2009 To cite this Article Smith, Lloyd V. and Duris, Joseph G.(2009

Smith, Lloyd V.

231

A Cabinet of Mathematical Curiosities at Teachers College: David Eugene Smith's Collection  

ERIC Educational Resources Information Center

This dissertation is a history of David Eugene Smith's collection of historical books, manuscripts, portraits, and instruments related to mathematics. The study analyzes surviving documents, images, objects, college announcements and catalogs, and secondary sources related to Smith's collection. David Eugene Smith (1860-1944) travelled…

Murray, Diane R.

2012-01-01

232

Edinburgh Research Explorer The Smith Commission and competition policymore power for  

E-print Network

Edinburgh Research Explorer The Smith Commission and competition policy­more power for Scottish Ministers? Citation for published version: Andreangeli, A, The Smith Commission and competition policy immediately and investigate your claim. Download date: 11. Dec. 2014 #12;The Smith Commission and competition

Millar, Andrew J.

233

The Hebrew University of Jerusalem The Robert H. Smith Faculty of Agriculture, Food & Environment  

E-print Network

The Hebrew University of Jerusalem The Robert H. Smith Faculty of Agriculture, Food & Environment H. Smith Faculty of Agriculture, Food & Environment, Herzl Street, POB 12, Rehovot, Israel 7610001 Studies of the Hebrew University's Robert H. Smith Faculty of Agriculture, Food & Environment

Anat, Maril,

234

The strategy concept and John Maynard Smith's influence on theoretical biology  

E-print Network

The strategy concept and John Maynard Smith's influence on theoretical biology MANFRED D, as it was introduced into biology by John Maynard Smith, is a prime illustration of the four dimensions of theoretical dispute that John Maynard Smith was one of the towering figures in theoretical biology during the second

235

APOBEC3G: a Double Agent in Defense Harold C. Smith  

E-print Network

APOBEC3G: a Double Agent in Defense Harold C. Smith Department of Biochemistry and Biophysics to A3G having a requirement for a ssDNA Corresponding Author contacts: Harold C. Smith, Department and Dentistry, Rochester, NY 14642 USA, harold.smith@rochester.edu Voice: (585) 275-4267, FAX: (585) 275

Levin, Judith G.

236

76 FR 26767 - Captain John Smith Chesapeake National Historic Trail Advisory Council  

Federal Register 2010, 2011, 2012, 2013

...INTERIOR National Park Service Captain John Smith Chesapeake National Historic Trail...that the Advisory Committee on the Captain John Smith Chesapeake National Historic Trail...tracing the 1607-1609 voyages of Captain John Smith to chart the land and waterways...

2011-05-09

237

76 FR 52691 - Captain John Smith Chesapeake National Historic Trail Advisory Council  

Federal Register 2010, 2011, 2012, 2013

...INTERIOR National Park Service Captain John Smith Chesapeake National Historic Trail...that the Advisory Committee on the Captain John Smith Chesapeake National Historic Trail...tracing the 1607-1609 voyages of Captain John Smith to chart the land and waterways...

2011-08-23

238

Inequality and the Dayton Tax-Budget Plan Jay Coggins and Dane Smith  

E-print Network

and Dane Smith Inequality and the Dayton Tax-Budget Plan #12;% growth in income, bottom quintile, 1979 Coggins and Dane Smith Inequality and the Dayton Tax-Budget Plan #12;% growth in income, bottom 99%, 1979Inequality and the Dayton Tax-Budget Plan Jay Coggins and Dane Smith Department of Applied

Weiblen, George D

239

2010 MSU Horticulture Gardens Glass Art by Craig Mitchell Smith Photos by Art and Marlene Cameron  

E-print Network

2010 MSU Horticulture Gardens ­ Glass Art by Craig Mitchell Smith Photos by Art and Marlene Cameron #12;2010 MSU Horticulture Gardens ­ Glass Art by Craig Mitchell Smith Photos by Art and Marlene Cameron #12;2010 MSU Horticulture Gardens ­ Glass Art by Craig Mitchell Smith Photos by Art and Marlene

240

Smith theory and the functor T William G. Dwyer and Clarence W. Wilkerson  

E-print Network

Smith theory and the functor T William G. Dwyer and Clarence W spaces [DMW1] [DMW2]. In this paper we will use techniques of Smith theory [DW] to calculate the functor which we will not discuss here our calculation produces a direct analogue of Smith theory (1

Wilkerson, Clarence

241

Smith theory and the functor T William G. Dwyer and Clarence W. Wilkerson  

E-print Network

Smith theory and the functor T William G. Dwyer and Clarence W. Wilkerson University of Notre Dame]. In this paper we will use techniques of Smith theory [DW] to calculate the functor T explicitly in certain key here our calculation produces a direct analogue of Smith theory (1.2) for actions of elementary abelian

Wilkerson, Clarence

242

Functional Food Product Development Jim Smith and Edward Charter  

E-print Network

Functional Food Product Development Edited by Jim Smith and Edward Charter Prince Edward Island Food Technology Centre Charlottetown, Canada A John Wiley & Sons, Ltd., Publication #12;#12;Functional Food Product Development #12;A John Wiley & Sons, Ltd., Publication Functional Food Science

Haddadi, Hamed

243

Improved amino acid flexibility parameters DAVID K. SMITH,1  

E-print Network

. KEITH DUNKER,3 AND GUANG ZHU4 1 Biochemistry Department, The University of Hong Kong, Pok Fu Lam, Hong, USA 4 Biochemistry Department, Hong Kong University of Science and Technology, Clear Water Bay (Karplus and Schulz 1985; Vihinen et al. Reprint requests to: David K. Smith, Biochemistry Department

Obradovic, Zoran

244

Right Size, Right Way: Smith College's Successful Voluntary Separation Plan.  

ERIC Educational Resources Information Center

The program of voluntary separation at Smith College (Massachusetts), implemented as an alternative to forced staff layoffs, is described. The plan included generous separation benefits and counseling services. Related issues are discussed, including tax considerations, eligibility, cost estimation, the plan's timeline, information dissemination,…

Lovell, Jonathan B.; Keefe, Janice A.

1992-01-01

245

Science fictions: Comment on Godfrey-Smith Arthur Fine  

E-print Network

. That is not the attitude of Peter Godfrey-Smith, who sees fictions as important in a certain scientific style that he. Vaihinger was inclined to see fictions of one sort or another in almost all scientific theorizing refers to as ``model-based science'', but not ubiquitous in scientific practice more generally

Fine, Arthur

246

AARON SMITH Department of Agricultural and Resource Economics  

E-print Network

), Energy Journal, forthcoming, 2014. CV: Aaron Smith, 8/28/2014, Page 1 of 6 #12;Publications (continued-98, Center for Teaching Development, UCSD. Lecturer, 1994-95, Jul/Aug 1996, Jul/Aug 2000, University 1994. Publications "Futures Market Failure?" (with Scott Irwin and Philip Garcia), American Journal

California at Davis, University of

247

Smith-Magenis Syndrome: Genetic Basis and Clinical Implications  

ERIC Educational Resources Information Center

Smith-Magenis syndrome (SMS) is a neurobehavioral disorder associated with deletions and mutations of the "RAI1" gene on chromosome 17p11.2. Clinical features of the syndrome include intellectual disability, sleep disturbance, craniofacial differences, and a distinctive profile of stereotypic and self-injurious behaviors. Although the functional…

Finucane, Brenda; Haas-Givler, Barbara

2009-01-01

248

TIGHT CLOSURE IN GRADED RINGS Karen E. Smith \\Lambda  

E-print Network

TIGHT CLOSURE IN GRADED RINGS Karen E. Smith \\Lambda Abstract. This paper facilitates the computation of tight closure by giving giv­ ing upper and lower bounds on the degrees of elements that need to be checked for inclusion in the tight closure of certain homogeneous ideals in a graded ring. Dif­ ferential

Smith, Karen E.

249

A taxonomy of granular partitions Thomas Bittner and Barry Smith  

E-print Network

A taxonomy of granular partitions Thomas Bittner and Barry Smith Qualitative Reasoning Group categorizations of the geospatial domain. 1 Introduction Imagine that you are (a) a geologist classifying soil in these cells are your soil samples. In case (b) the cells are labeled with the names of vegetation classes

Forbus, Kenneth D.

250

Pharmacological Cognitive Enhancers: Comment on Smith and Farah (2011)  

ERIC Educational Resources Information Center

Smith and Farah (2011) provided a thought-provoking and perhaps deliberately provocative literature review of the use of stimulants to improve cognitive functioning in humans. They addressed the apparently increasing willingness of individuals mostly in the United States to use stimulants for this purpose and then summarized published literature…

Elliott, Glen R.; Elliott, Mark D.

2011-01-01

251

Northern Blots (based on protocol from Mitch Smith Lab)  

E-print Network

Auble Lab Northern Blots (based on protocol from Mitch Smith Lab) Use gel apparatus designated in microwave and cool a little Add 10 ml 10X MOPS and 17 ml 37% Formaldehyde Pour. 10X MOPS 0.2 M MOPS 23.1 g per 5 ml of Hybridization Solution) Use roller bottle in hybridization oven. Hybridization Solution

Auble, David

252

Wholemovement of the circle Bradford Hansen-Smith  

E-print Network

171 Wholemovement of the circle Bradford Hansen-Smith 4606 N. Elston #3, Chicago IL 60630, USA brad that demonstrates the concept of Wholeness. When compressed to a single plane, the sphere is reformed to a circle into the Wholeness of this energy creation. The circle is a compressed, reformed sphere. Everything we #12;172 know

Spagnolo, Filippo

253

Adam Smith and the Teaching of English Literature.  

ERIC Educational Resources Information Center

Adam Smith used selections from English literature in his classroom during the eighteenth century because he believed that vernacular literature could provide a ready context for the teaching of ideological, social, and moral lessons. He believed that higher education should prepare students for the real business of the real world. (RM)

Court, Franklin E.

1985-01-01

254

Adam Smith and the Moral Economy of the Classroom System.  

ERIC Educational Resources Information Center

Traces the development of mass schooling to its origins in 19th-century Glasgow. Its importance as an intellectual and economic center enabled Glasgow to invent a solution to the problem of urban schooling, while the association of scholars like Adam Smith with Glasgow University made Scottish educational theories acceptable around the world. (DB)

Hamilton, D.

1980-01-01

255

TROPHIC DYNAMICS OF STRIPED BASS IN SMITH MOUNTAIN LAKE, VIRGINIA  

EPA Science Inventory

We examined the adequacy of the forage base to meet demand of striped bass in Smith Mountain Lake, Virginia. In regards to prey supply, mean alewife biomass from 1993-1998 was 37 kg/ha and mean gizzard shad biomass from 1990-1997 was 112 kg/ha. Mean annual alewife surplus produ...

256

Karen Smith: Language Arts Educator of the Year  

ERIC Educational Resources Information Center

This article honors Karen Smith, who has been given NCTE's Outstanding Educator in the English Language Arts award for 2009. Through the voices of many colleagues and former students, the article celebrates Karen as a teacher, learner, mentor, collaborator, scholar, storyteller, and visionary thinker and doer.

Hudelson, Sarah

2009-01-01

257

Variable efficacy of repeated annual influenza vaccination Derek J. Smith,  

E-print Network

Variable efficacy of repeated annual influenza vaccination Derek J. Smith, ¢¡ Stephanie Forrest-665-3493. Running head: Annual influenza vaccination. Classification: Medical Science Keywords: influenza, vaccination, original antigenic sin, vaccine efficacy, repeated vaccination. 1 #12;ABSTRACT Conclusions have

Forrest, Stephanie

258

Building a Strong and Resilient Family1 Suzanna Smith2  

E-print Network

FCS2057 Building a Strong and Resilient Family1 Suzanna Smith2 1. This document is FCS2057, one. By reducing unnecessary pressures, you can increase time for your family. #12;Building a Strong and Resilient and psychological health, but this is an important word to families too. Research shows that individual wellness

Jawitz, James W.

259

Harry Smith — recipient of the 2008 Molecular Ecology Prize  

Technology Transfer Automated Retrieval System (TEKTRAN)

Harry Smith is a scholar, mentor, internationally renowned researcher, eloquent speaker and author, pioneering journal editor and highly valued colleague who has contributed greatly in multiple ways to plant science and the community. He richly deserves the honour of the Molecular Ecology Prize....

260

Obituary: Harding Eugene (Gene) Smith, Jr., 1947-2007  

Microsoft Academic Search

Harding Eugene Smith Junior, or Gene, as he was known to family, friends, and colleagues, passed away after an automobile accident in Encinitas, California, on 16 August 2007. He was 60 years old. Gene had recently retired from UCSD after thirty years of service. A memorial service was held at Quail Botanical Gardens in Encinitas, California, on 23 August 2007.

Carol Lonsdale; Tom Soifer

2009-01-01

261

Undergraduate Representation Theory: Exercise Set 6 Professor Karen Smith  

E-print Network

Undergraduate Representation Theory: Exercise Set 6 Professor Karen Smith Reading: Fulton to this representation. Describe an explicit decomposition into irreducible subrepresentations. 2. Now consider the "same). (The technical term for this repre- sentation is the tensor product of the original real representation

Smith, Karen E.

262

Undergraduate Representation Theory: Exercise Set 5 Professor Karen Smith  

E-print Network

Undergraduate Representation Theory: Exercise Set 5 Professor Karen Smith Reading: Review of linear algebra if needed (construction of tensor products, etc.) Problem 1: The permutation representation of S3 representations. Problem 2: Which of the following representations are irreducible? 1. The tautological

Smith, Karen E.

263

CURRICULUM VITAE -RYAN H SMITH Atlantic Oceanographic and Meteorological Laboratory  

E-print Network

, during the Deepwater Horizon oil spill. Cont. Shelf Res., 77, 118-131. Muhling, Barbara A., R. H. Smith and satellite measurements to examine the extent and variability of the DWH oil spill. Deepwater Horizon Oil Spill Principal Investigator Workshop: Final Report. 2012. National Science and Technology Council

264

from "The Celebes" (Sulawesi), Apis nigrocincta Fabr. Smith, 1861. However,  

E-print Network

from "The Celebes" (Sulawesi), Apis nigrocincta Fabr. Smith, 1861. However, most reports about-nest- ing honey bees inhabit Sulawesi and the sur- rounding islands of Indonesia. Maa (1953) recognized Sulawesi, Indonesia were quantitatively analyzed by gas chromatography- mass spectrometry for several

Paris-Sud XI, Université de

265

Smith and Valley-Gray to Lead NASP  

ERIC Educational Resources Information Center

The 2011 elections are complete and Amy Smith has been elected to lead NASP in 2012. Amy has a long history of serving her state and national professional organizations, most recently as NASP program manager for advocacy and before that as the Pennsylvania delegate and Northeast Region delegate representative. She served the Association of School…

Deupree, Charles

2011-01-01

266

Looking east at canal and R. Paul Smith Power Station. ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Looking east at canal and R. Paul Smith Power Station. The dark trestle at right center carried the spur track to coal unloading facilities located in the space now occupied by the coal pile. - Potomac Edison Company, Chesapeake & Ohio Canal Bridge, Spanning C & O Canal South of U.S. 11, Williamsport, Washington County, MD

267

James M. Coughlan Smith-Kettlewell Eye Research Institute  

E-print Network

of the Problem 3-D lines in Manhattan scene project to lines on uv image plane. cr ar fu rr rr = cr br fv rr rrJames M. Coughlan Smith-Kettlewell Eye Research Institute Manhattan World: Orientation and Outlier Detection by Bayesian Inference #12;Application of the statistics of edges: Manhattan World Many scenes

Coughlan, James M.

268

A NEW SET OF THERMAL CONDUCTIVITY MEASUREMENTS Michael Smith1  

E-print Network

A NEW SET OF THERMAL CONDUCTIVITY MEASUREMENTS Michael Smith1 ,Bruce Jamieson1 2 1 Dept. of Civil, AB, Canada ABSTRACT: A new set of thermal conductivity measurements collected over the course of one for empirical relationships between thermal conductivity and layer density. Further subsetting by moist or dry

Jamieson, Bruce

269

A Domain Wall Theory for Ferroelectric Hysteresis Ralph C. Smith  

E-print Network

A Domain Wall Theory for Ferroelectric Hysteresis Ralph C. Smith Center for Research in Scientific.hom@lmco.com Abstract This paper addresses the modeling of hysteresis in ferroelectric materials through consideration comparison with experimental data from a PMN­PT­BT actuator operating at a temperature within

270

A Domain Wall Theory for Ferroelectric Hysteresis Ralph C. Smith  

E-print Network

A Domain Wall Theory for Ferroelectric Hysteresis Ralph C. Smith Center for Research in Scienti c.hom@lmco.com Abstract This paper addresses the modeling of hysteresis in ferroelectric materials through consideration comparison with experimental data from a PMN-PT-BT actuator operating at a temperature within

271

Channel erosion due to subsurface flow Braunen Smith,1  

E-print Network

Channel erosion due to subsurface flow Braunen Smith,1 Arshad Kudrolli,1 Alexander E. Lobkovsky,2 through the porous medium and creates channels on the slope above a critical pressure which depends on the slope of the bed. We obtain the depth of channels as a function of time using the intersection

Kudrolli, Arshad

272

FUZZY SPATIAL DATA MINING George Brannon Smith Susan M. Bridges  

E-print Network

FUZZY SPATIAL DATA MINING George Brannon Smith Susan M. Bridges Department of Computer Science Box@cs.mssstate.edu Abstract A fuzzy spatial data mining technique has been developed to extract relationships describing been tested with hand-generated, synthetic, and sonar imagery. Keywords: data mining, spatial relations

Bridges, Susan M.

273

A search for star formation in the Smith Cloud  

NASA Astrophysics Data System (ADS)

Motivated by the idea that a subset of high-velocity clouds (HVCs) trace dark matter substructure in the Local Group, we search for signs of star formation in the Smith Cloud, a nearby ˜2 × 106 M? HVC currently falling into the Milky Way. Using GALEX NUV and WISE/2MASS NIR photometry, we apply a series of colour and apparent magnitude cuts to isolate candidate O and B stars that are plausibly associated with the Smith Cloud. We find an excess of stars along the line of sight to the cloud, but not at a statistically significant level relative to a control region. The number of stars found in projection on the cloud after removing an estimate of the contamination by the Milky Way implies an average star formation rate surface density of 10-4.8±0.3 M? yr-1 kpc-2, assuming the cloud has been forming stars at a constant rate since its first passage through the Milky Way ˜70 Myr ago. This value is consistent with the star formation rate expected based on the average gas density of the cloud. We also discuss how the newly discovered star-forming galaxy Leo P has very similar properties to the Smith Cloud, but its young stellar population would not have been detected at a statistically significant level using our method. Thus, we cannot yet rule out the idea that the Smith Cloud is really a dwarf galaxy.

Stark, David V.; Baker, Ashley D.; Kannappan, Sheila J.

2015-01-01

274

SAMPLE COVER LETTER for BIOTECH INTERNSHIP Aaron Smith  

E-print Network

SAMPLE COVER LETTER for BIOTECH INTERNSHIP Aaron Smith 12 Echo Street Cambridge, MA 55555 September 14, 20xx Ms. Caroline Burnett Boston Biotech Company Somewhere, MA 55555 Dear Ms. Burnett job listings at the Brandeis University Career Center. Boston Biotech is a leader in the advancement

Fraden, Seth

275

PYTHAGOREAN -FIELDS Thomas C. Craven and Tara L. Smith  

E-print Network

PYTHAGOREAN -FIELDS Thomas C. Craven and Tara L. Smith Abstract. We generalize the usual notion of pythagorean field (every sum of squares is a square) to the setting of division rings D with involution. We group homomorphism of the Witt group of anisotropic hermitian forms W(D, ) into C(YD, Z) [Cr3, Theorem 2

Craven, Thomas C.

276

The Garrett Lee Smith Memorial Suicide Prevention Program  

ERIC Educational Resources Information Center

In response to calls for greater efforts to reduce youth suicide, the Garrett Lee Smith (GLS) Memorial Act has provided funding for 68 state, territory, and tribal community grants, and 74 college campus grants for suicide prevention efforts. Suicide prevention activities supported by GLS grantees have included education, training programs…

Goldston, David B.; Walrath, Christine M.; McKeon, Richard; Puddy, Richard W.; Lubell, Keri M.; Potter, Lloyd B.; Rodi, Michael S.

2010-01-01

277

Nonlinear Commuted Synthesis of Bowed Strings Julius O. Smith III  

E-print Network

Nonlinear Commuted Synthesis of Bowed Strings Julius O. Smith III CCRMA, Music Department, Stanford the effects of multiple bow hairs. The pulsed noise may also include qualitatively the impulse responses Friction 3 4 Friction Impulse Detection 4 5 Pulsed Noise 5 6 Simulation Results 6 7 Conclusions 6 8

Smith III, Julius Orion

278

A glossary for stem-cell biology Austin Smith1  

E-print Network

. The definitive assay for haematopoietic, epidermal and spermatogonial stem cells. Transplantation assay mayA glossary for stem-cell biology Austin Smith1 Stem-cell biology is in a phase of dynamic expansion exposed to public and political scrutiny. A common language in the stem-cell community is an important

Cai, Long

279

Greta Smith Aeby Hawaii Institute of Marine Biology  

E-print Network

Greta Smith Aeby Hawaii Institute of Marine Biology PO Box 1346 Kaneohe, HI 96744 Work, TM, Forsman, Williams, GJ, Franklin, EC, Kenyon, J, Cox, EF, Coles, S and TM Work. 2011. Patterns of coral disease across the Hawaiian archipelago: relating disease to environment. PLoS ONE 6(5):e20370. Williams, G

Wang, Yuqing

280

10/24/11, Page 1 VITA -Doug Smith  

E-print Network

-mantle separation: Re-Os isotopic study of mafic xenoliths from central Arizona. Geology, v. 25, 651-654. #1210/24/11, Page 1 VITA - Doug Smith Education: B.S., Geology, 1962, California Institute of Technology A.M., Geology, 1963, Harvard University Ph.D., Geology, 1969, California Institute of Technology

Yang, Zong-Liang

281

X-29 Research Pilot Rogers Smith  

NASA Technical Reports Server (NTRS)

Rogers Smith, a NASA research pilot, is seen here at the cockpit of the X-29 forward-swept-wing technology demonstrator at NASA's Ames-Dryden Flight Research Facility (later the Dryden Flight Research Center), Edwards, California, in 1988. The X-29 explored the use of advanced composites in aircraft construction; variable camber wing surfaces; the unique forward-swept-wing and its thin supercritical airfoil; strake flaps; and a computerized fly-by-wire flight control system that overcame the aircraft's instability. Grumman Aircraft Corporation built two X-29s. They were flight tested at Dryden from 1984 to 1992 in a joint NASA, DARPA (Defense Advanced Research Projects Agency) and U.S. Air Force program. Two X-29 aircraft, featuring one of the most unusual designs in aviation history, flew at the Ames-Dryden Flight Research Facility (now the Dryden Flight Research Center, Edwards, California) from 1984 to 1992. The fighter-sized X-29 technology demonstrators explored several concepts and technologies including: the use of advanced composites in aircraft construction; variable-camber wing surfaces; a unique forward- swept wing and its thin supercritical airfoil; strakes; close-coupled canards; and a computerized fly-by-wire flight control system used to maintain control of the otherwise unstable aircraft. Research results showed that the configuration of forward-swept wings, coupled with movable canards, gave pilots excellent control response at angles of attack of up to 45 degrees. During its flight history, the X-29 aircraft flew 422 research missions and a total of 436 missions. Sixty of the research flights were part of the X-29 follow-on 'vortex control' phase. The forward-swept wing of the X-29 resulted in reverse airflow, toward the fuselage rather than away from it, as occurs on the usual aft-swept wing. Consequently, on the forward-swept wing, the ailerons remained unstalled at high angles of attack. This provided better airflow over the ailerons and prevented stalling (loss of lift) at high angles of attack. Introduction of composite materials in the 1970s opened a new field of aircraft construction. It also made possible the construction of the X-29's thin supercritical wing. State-of-the-art composites allowed aeroelastic tailoring which, in turn, allowed the wing some bending but limited twisting and eliminated structural divergence within the flight envelope (i.e. deformation of the wing or the wing breaking off in flight). Additionally, composite materials allowed the wing to be sufficiently rigid for safe flight without adding an unacceptable weight penalty. The X-29 project consisted of two phases plus the follow-on vortex-control phase. Phase 1 demonstrated that the forward sweep of the X-29 wings kept the wing tips unstalled at the moderate angles of attack flown in that phase (a maximum of 21 degrees). Phase I also demonstrated that the aeroelastic tailored wing prevented structural divergence of the wing within the flight envelope, and that the control laws and control-surface effectiveness were adequate to provide artificial stability for an otherwise unstable aircraft. Phase 1 further demonstrated that the X-29 configuration could fly safely and reliably, even in tight turns. During Phase 2 of the project, the X-29, flying at an angle of attack of up to 67 degrees, demonstrated much better control and maneuvering qualities than computational methods and simulation models had predicted . During 120 research flights in this phase, NASA, Air Force, and Grumman project pilots reported the X-29 aircraft had excellent control response to an angle of attack of 45 degrees and still had limited controllability at a 67-degree angle of attack. This controllability at high angles of attack can be attributed to the aircraft's unique forward-swept wing- canard design. The NASA/Air Force-designed high-gain flight control laws also contributed to the good flying qualities. During the Air Force-initiated vortex-control phase, the X-29 successfully demonstrated vortex flow control (VFC). This VFC was more effective t

1988-01-01

282

Fenimore Art Museum: The Smith and Telfer Photographic Collection  

NSDL National Science Digital Library

The Fenimore Art Museum in New York has a wide-ranging collection that includes significant pieces of American Indian art, folk art, and thousands of photographs and negatives. Working together with other institutions, including the New York State Historical Association, they have digitized over 300 images from the Smith and Telfer Photographic Collection. The firm of Smith and Telfer documented the town of Cooperstown, NY for well over a century, and they took photos of circus animals, civic monuments, and prominent individuals. Visitors can browse through the images at their leisure, and they can also search the entire collection by keyword. A couple of images of note include the shot of a man holding a dog in his lap while sitting on a tractor ("Ainslie Cornfield") and the photo entitled "Balloon Ascension".

283

Defenses and morality: Adam Smith, Sigmund Freud, and contemporary psychoanalysis.  

PubMed

In this paper we follow the development and transmission of moral learning from Adam Smith's impartial spectator to Sigmund Freud's superego and then to contemporary psychoanalysis. We argue that defenses are an integral component in the acquisition of any moral system. Elaborating on this argument, we assert that there is a progression from defensive systems that are "closed" to defensive systems that are "open," as defined in a recent work by Novick and Novick. The former system is "static, avoids reality, and is characterized by power dynamics, sadomasochism, and omnipotent defense." The latter, on the other hand, is a system that allows for "joy, creativity, spontaneity, love and it is attuned to reality." Furthermore, while Smith and Freud's systems are more one-person systems of defense, contemporary psychoanalysis has moved to more of a two-person system. PMID:25247288

Gabrinetti, Paul A; Özler, Sule

2014-10-01

284

Constitutive relations associated with the Mott-Smith distribution function  

USGS Publications Warehouse

It is shown that the distribution function assumed by Mott-Smith determines a unique relation between heat flux, stress, and fluid velocity given by q = (3/2)??u, i.e., it provides a constitutive relation for heat flux, and it also determines a simple expression for this ratio of third-order central moments Q = . These expressions allow the equation of transfer for c x2 to be cast in a form that yields a nonlinear constitutive relation for stress. The results obtained from the Mott-Smith ansatz are compared with the theory of Baganoff and Nathenson and results from a numerical solution of the Boltzmann equation for shock-wave structure obtained by Hicks and Yen.

Nathenson, M.; Baganoff, D.

1973-01-01

285

Smith–Lemli–Opitz syndrome: pathogenesis, diagnosis and management  

Microsoft Academic Search

Smith–Lemli–Opitz syndrome (SLOS) is a malformation syndrome due to a deficiency of 7-dehydrocholesterol reductase (DHCR7). DHCR7 primarily catalyzes the reduction of 7-dehydrocholesterol (7DHC) to cholesterol. In SLOS, this results in decreased cholesterol and increased 7DHC levels, both during embryonic development and after birth. The malformations found in SLOS may result from decreased cholesterol, increased 7DHC or a combination of these

Forbes D Porter

2008-01-01

286

Smith-Magneis syndrome: behavioural phenotype mimics ADHD.  

PubMed

A mentally retarded 7-year-old male child presented with inattention and hyperactivity which was initially diagnosed as attention deficit hyperactivity disorder (ADHD). However, a careful evaluation of symptomatology along with clues provided by specific features of facial dysmorphism in this case along with genetic testing clinched the diagnosis of Smith-Magneis syndrome the behavioural phenotype of which closely resembles ADHD. PMID:24395876

Gnanavel, Sundar

2014-01-01

287

Building Energy Audit Report for Camp Smith, HI  

SciTech Connect

A detailed energy assessment was performed by a team of engineers from Pacific Northwest National Laboratory (PNNL) under contract to the Department of Energy/Federal Energy Management program (FEMP). The effort used the Facility Energy Decision System (FEDS) model to determine how energy is consumed at Camp Smith, identify the most cost-effective energy retrofit measures, and calculate the potential energy and cost savings. This report documents the results of that assessment.

Chvala, William D.; De La Rosa, Marcus I.; Brown, Daryl R.; Dixon, Douglas R.

2010-09-30

288

Paternity and paternal care in the polygynandrous Smith's longspur  

Microsoft Academic Search

In species where females copulate with more than one male during a single breeding attempt, males risk investing in offspring\\u000a that are not their own. In the polygynandrous Smith's longspur (Calcarius pictus), females copulate sequentially with one to three males for each clutch of eggs and most of these males later assist in feeding\\u000a the young. Using multilocus DNA profiling,

James V. Briskie; Robert Montgomerie; Tarmo Põldmaa; Peter T. Boag

1998-01-01

289

Definition of the critical interval for Smith-Magenis syndrome  

Microsoft Academic Search

Smith-Magenis syndrome (SMS) comprises a complex physical and behavioral phenotype that is associated with an interstitial deletion of chromosome 17p11.2. The deletions observed in patients can range from <2 to >9 megabases of DNA and may include more than 100 genes. In order to determine the critical deletion interval responsible for the syndrome phenotype, we have examined several patients with

S. H. Elsea; S. M. Purandare; R. A. Adell; R. C. Juyal; J. G. Davis; B. Finucane; R. E. Magenis; P. I. Patel

1997-01-01

290

Wayne Smith Leadership Award Application The Wayne Smith Leadership Award was established "To be used at the discretion of the Director of the School  

E-print Network

Wayne Smith Leadership Award Application The Wayne Smith Leadership Award was established "To be used at the discretion of the Director of the School to support leadership of professional projects of student organizations in the School and/or to support student leaders who participate in formal leadership

Watson, Craig A.

291

Case report: Adult phenotype of Mulvihill-Smith syndrome.  

PubMed

Mulvihill-Smith syndrome (MSS) is characterized by premature aging, multiple pigmented nevi, decreased facial subcutaneous fat, microcephaly, short stature, mental retardation and recurrent infections, however the adult phenotype of MSS has yet to be delineated. We report a 28-year-old woman with Mulvihill-Smith syndrome, who had a solid pseudopapillary cystic tumor of her pancreas at age 17 years. Her distinctive sleep pattern includes severe insomnia with disappearance of sleep spindles and K-complexes, persisting muscle tone, and loss of slow wave sleep. The clinical and neurophysiological studies are compatible with agrypnia excitata, a sleep disorder attributable to a dysfunction of the thalamo-limbic system. Brain magnetic resonance imaging and single photon emission computed tomography revealed structural and functional deficits in the dorsomedial region of the thalamus and indicated that an alteration in the thalamo-limbic system may underlie the sleep disturbances in MSS. Furthermore, the rapid and severe decline in acquired cognitive function showed the distinct cognitive impairments resembling dementia, including intellectual deficits, memory disorder and executive dysfunction. We posit that an early onset tumor, sleep disorder and cognitive decline are adult manifestations of Mulvihill-Smith syndrome. PMID:19213035

Yagihashi, Tatsuhiko; Kato, Motoichiro; Izumi, Kosuke; Kosaki, Rika; Yago, Kaori; Tsubota, Kazuo; Sato, Yuji; Okubo, Minoru; Watanabe, Goro; Takahashi, Takao; Kosaki, Kenjiro

2009-03-01

292

Corruption des travailleurs et ducation dans les socits commerciales selon Adam Smith1  

E-print Network

1 Corruption des travailleurs et éducation dans les sociétés commerciales selon Adam Smith1 Benoît Walraevens2 Résumé : Cet article vise à démontrer la richesse et l'originalité de l'analyse par Smith des effets déshumanisants de la division du travail. Nous soulignons tout d'abord comment Smith se

Boyer, Edmond

293

Rotavirus vaccines: targeting the developing world.  

PubMed

For the past 2 decades, rotavirus infection, the most common cause of severe diarrhea in children, has been a priority target for vaccine development. This decision to develop rotavirus vaccines is predicated on the great burden associated with fatal rotavirus disease (i.e., 440,000 deaths/year), the firm scientific basis for developing live oral vaccines, the belief that increased investment in development at this time could speed the introduction of vaccines in developing countries, and the appreciation that implementation of a vaccine program should result in a measurable decrease in the number of hospitalizations and deaths associated with rotavirus disease within 2-3 years. RotaShield (Wyeth-Ayerst), the first rotavirus vaccine licensed in the United States, was withdrawn after 9 months because of a rare association of the vaccine with the development of intussusception. In the developing world, this vaccine could still have had a measurable effect, because the benefits of preventing deaths due to rotavirus disease would have been substantially greater than the rare risk of intussusception. Two live oral vaccines being prepared by GlaxoSmithKline and Merck have completed large-scale clinical trials. The GlaxoSmithKline vaccine has been licensed in Mexico and the Dominican Republic, and the Merck vaccine could be licensed in the United States within 1 year; several other candidate vaccines are in earlier stages of testing. However, many challenges remain before any of these vaccines can be incorporated into childhood immunization programs in the developing world. First, vaccine efficacy, which has already been demonstrated in children in industrialized and middle-income countries, needs to be proven in poor developing countries in Africa and Asia. The safety of vaccines with regard to the associated risk of intussusception must be demonstrated as well. Novel financing strategies will be needed to ensure that new vaccines are affordable and available in the developing world. Decision makers and parents in developing countries need to know about this disease that has little name recognition and is rarely diagnosed. Finally, for the global effort toward the prevention of rotavirus disease to be successful, special efforts will be required in India, China, and Indonesia, because one-third of all deaths due to rotavirus disease occur in these countries, and because these countries depend almost entirely on vaccines manufactured domestically. PMID:16088799

Glass, Roger I; Bresee, Joseph S; Turcios, Reina; Fischer, Thea K; Parashar, Umesh D; Steele, A Duncan

2005-09-01

294

Increasing class one fruit in 'Granny Smith' and 'Cripps' Pink' apple.  

E-print Network

??Thesis (MscAgric (Horticulture)) – University of Stellenbosch, 2009. ENGLISH ABSTRACT: Experiments were conducted to increase the percentage class one ‘Granny Smith’ and ‘Cripps’ Pink’ apples. ‘Granny… (more)

Fouche, Jacques Roux

2009-01-01

295

STS-110 M.S. Smith suits up for TCDT  

NASA Technical Reports Server (NTRS)

KENNEDY SPACE CENTER, FLA. -- STS-110 Mission Specialist Steven Smith relaxes during suit fit, which is part of Terminal Countdown Demonstration Test activities. The TCDT is held at KSC prior to each Space Shuttle flight to provide flight crews an opportunity to participate in simulated launch countdown activities. Scheduled for launch April 4, the 11-day mission will feature Shuttle Atlantis docking with the International Space Station (ISS) and delivering the S0 truss, the centerpiece-segment of the primary truss structure that will eventually extend over 300 feet.

2002-01-01

296

Smith Newton Vehicle Performance Evaluation - 1st Quarter 2014 (Brochure)  

SciTech Connect

The Fleet Test and Evaluation Team at the U.S. Department of Energy's National Renewable Energy Laboratory is evaluating and documenting the performance of electric and plug-in hybrid electric drive systems in medium-duty trucks across the nation. U.S. companies participating in this evaluation project received funding from the American Recovery and Reinvestment Act to cover part of the cost of purchasing these vehicles. Through this project, Smith Electric Vehicles is building and deploying 500 all-electric medium-duty trucks that will be deployed by a variety of companies in diverse climates across the country.

Not Available

2014-04-01

297

Smith Newton Vehicle Performance Evaluation - Gen2 - 2013 (Brochure)  

SciTech Connect

The Fleet Test and Evaluation Team at the U.S. Department of Energy's National Renewable Energy Laboratory is evaluating and documenting the performance of electric and plug-in hybrid electric drive systems in medium-duty trucks across the nation. U.S. companies participating in this evaluation project received funding from the American Recovery and Reinvestment Act to cover part of the cost of purchasing these vehicles. Through this project, Smith Electric Vehicles is building and deploying 500 all-electric medium-duty trucks that will be deployed by a variety of companies in diverse climates across the country.

Not Available

2014-04-01

298

Smith Newton Vehicle Performance Evaluation - Gen 2 - Cumulative (Brochure)  

SciTech Connect

The Fleet Test and Evaluation Team at the U.S. Department of Energy's National Renewable Energy Laboratory is evaluating and documenting the performance of electric and plug-in hybrid electric drive systems in medium-duty trucks across the nation. U.S. companies participating in this evaluation project received funding from the American Recovery and Reinvestment Act to cover part of the cost of purchasing these vehicles. Through this project, Smith Electric Vehicles is building and deploying 500 all-electric medium-duty trucks that will be deployed by a variety of companies in diverse climates across the country.

Not Available

2014-08-01

299

Adam Smith and the Making of the Modern World  

E-print Network

be potentially interested in one or two of the authors treated, but not all of them at once. So I have decided to re-issue each part as a downloadable electronic book, and add others parts of my exploration of the riddle of modernity in due course... , then, it seemed that there was something approaching a valid experiment for the verification of an hypothesis, and confirming it up to the hilt.8 Smith was living just before the great textile and steam power boom of the later eighteenth...

Macfarlane, Alan

2013-01-01

300

The futility of utility: how market dynamics marginalize Adam Smith  

NASA Astrophysics Data System (ADS)

Economic theorizing is based on the postulated, nonempiric notion of utility. Economists assume that prices, dynamics, and market equilibria are supposed to be derived from utility. The results are supposed to represent mathematically the stabilizing action of Adam Smith's invisible hand. In deterministic excess demand dynamics I show the following. A utility function generally does not exist mathematically due to nonintegrable dynamics when production/investment are accounted for, resolving Mirowski's thesis. Price as a function of demand does not exist mathematically either. All equilibria are unstable. I then explain how deterministic chaos can be distinguished from random noise at short times. In the generalization to liquid markets and finance theory described by stochastic excess demand dynamics, I also show the following. Market price distributions cannot be rescaled to describe price movements as ‘equilibrium’ fluctuations about a systematic drift in price. Utility maximization does not describe equilibrium. Maximization of the Gibbs entropy of the observed price distribution of an asset would describe equilibrium, if equilibrium could be achieved, but equilibrium does not describe real, liquid markets (stocks, bonds, foreign exchange). There are three inconsistent definitions of equilibrium used in economics and finance, only one of which is correct. Prices in unregulated free markets are unstable against both noise and rising or falling expectations: Adam Smith's stabilizing invisible hand does not exist, either in mathematical models of liquid market data, or in real market data.

McCauley, Joseph L.

2000-10-01

301

Novel resonators for Smith-Purcell free-electron lasers  

NASA Astrophysics Data System (ADS)

A Smith-Purcell Free Electron Laser test-facility has been developed. The structure is used to conduct detailed explorations that novel resonator designs will have on tunability, start current and other performance criteria. Emphasis is on sources which operate at millimeter wavelengths and utilize moderate energy electron beams. The Smith-Purcell radiation is produced by passing a 3-15 kV, submillimeter diameter electron beam over a metal grating with a rectangular profile. Radiation is produced at 35-40 GHz, 75 GHz and 95-100 GHz using different gratings. Three resonator configurations have been investigated. Two are planar orotron designs with different quality factors. Starting currents as low as 1 to 10 mA have been observed in the 35-40 GHz range. A third configuration is a bare grating without an external feedback elements. Performance was equal or superior to the original planar orotron designs. Radiation from this structure is observed by looking for bound modes launched in the backward direction. Starting currents of 15 mA are observed and the wavelength is continuously tunable. This design is simpler and more robust and allows a better understanding of the operation of the device.

Platt, Christopher L.

1997-09-01

302

STS-103 Mission Specialist Smith suits up before launch  

NASA Technical Reports Server (NTRS)

After donning his launch and entry suit, sts-103 Mission Specialist Steven L. Smith shows a positive attitude over the second launch attempt for Space Shuttle Discovery. The previous launch attempt on Dec. 17 was scrubbed about 8:52 p.m. due to numerous violations of weather launch commit criteria at KSC. Smith and other crew members Commander Curtis L. Brown Jr., Pilot Scott J. Kelly and Mission Specialists C. Michael Foale (Ph.D.), John M. Grunsfeld (Ph.D.), Claude Nicollier of Switzerland and Jean-Francois Clervoy of France are scheduled to lift off at 7:50 p.m. EST Dec. 19 on mission STS-103, servicing the Hubble Space Telescope. Objectives for the nearly eight-day mission include replacing gyroscopes and an old computer, installing another solid state recorder, and replacing damaged insulation in the telescope. Discovery is expected to land at KSC Monday, Dec. 27, at about 5:24 p.m. EST.

1999-01-01

303

RESULTS & CONCLUSION The analysis (above) shows that there are multiple reaches of Trout Brook and Smith  

E-print Network

RESULTS & CONCLUSION The analysis (above) shows that there are multiple reaches of Trout Brook, the centerlines of Trout Brook and Smith Brook were traced, along with some tributaries, from their respective Trout Brook and Smith Brook in eastern Cortland County. Essentially this was a proof-of-concept project

Barclay, David J.

304

Two Rival Conceptions of Vocational Education: Adam Smith and Friedrich List.  

ERIC Educational Resources Information Center

Examines and discusses two views of political economy: (1) the classical model of Adam Smith; and (2) the social capitalist model associated with Friedrich List. Explores two varieties of vocational education and training that emerge from a comparison of Smith's and List's ideas. (CMK)

Winch, Christopher

1998-01-01

305

How To Survive in Postindustrial Environments: Adam Smith's Advice for Today's Colleges and Universities.  

ERIC Educational Resources Information Center

Adam Smith's discussion of the payment modes of teachers and resulting consequences for the quality of teaching and process of curricular innovation are reviewed through the conceptual lens of modern agency theory. Smith's analysis of higher education in his day (eighteenth century) sheds light on faculty incentive and assessment problems that…

Ortmann, Andreas

1997-01-01

306

Rhetorical Studies: A Reassessment of Adam Smith's Lectures on Rhetoric and Belles Lettres.  

ERIC Educational Resources Information Center

Offers a dissenting interpretation of Adam Smith's Lectures on Rhetoric and Belles Lettres and a more conservative perspective on Smith's significance to the history of rhetorical theory. Views the lectures as an historical commentary on literature and rhetoric from the perspective of an eighteenth-century lecturer. (JD)

Purcell, William M.

1986-01-01

307

CYCLIC MAPS IN RATIONAL HOMOTOPY THEORY GREGORY LUPTON AND SAMUEL BRUCE SMITH  

E-print Network

CYCLIC MAPS IN RATIONAL HOMOTOPY THEORY GREGORY LUPTON AND SAMUEL BRUCE SMITH Abstract. The notion, minimal models. 1 #12;2 GREGORY LUPTON AND SAMUEL BRUCE SMITH Theorem 1.1 ([Got69, Th.4.1,Th.5.1]). Let X

Smith, Sam

308

A Disciplinary Immigrant. Alexander Smith at the University of Chicago, 1894-1911  

ERIC Educational Resources Information Center

The publication in 1906 of Alexander Smith's "Introduction to general inorganic chemistry" inaugurated a decisive change in chemical pedagogy in the US, the effects of which are still evident. The nature and extent of Smith's innovations are described through a comparison of his text to its source material and contemporaries. His authoritative…

Cotter, Donald

2008-01-01

309

BY E..GUS COTHRAN, MICHAEL H. SMITH, JERRY O. WOLFF AND JOHN B. GENTRY  

E-print Network

BY E..GUS COTHRAN, MICHAEL H. SMITH, JERRY O. WOLFF AND JOHN B. GENTRY #12;SRO-NERP-21 MAMMALS OF THE SA VANNAH RIVER SITE E. GUS COTHRAN MICHAEL H. SMITH JERRY O. WOLFF AND JOHN B. GENTRY SAVANNAH Rnffi- Star-nosed Mole 58 Scalopus aquaticus howelli Jackson - Eastern Mole 59 Lasionycteris noctivagans (Le

Georgia, University of

310

Unconscious Odour Conditioning 25 Years Later: Revisiting and Extending "Kirk-Smith, Van Toller and Dodd"  

ERIC Educational Resources Information Center

The pioneering work by Kirk-Smith, Van Toller, and Dodd [Kirk-Smith, M. D., Van Toller, C., & Dodd, G. H. (1983). "Unconscious odour conditioning in human subjects." "Biological Psychology," 17, 221-231], established that an unnoticed odorant paired with an emotionally meaningful task can influence mood and attitudes when the odorant alone is…

Zucco, Gesualdo M.; Paolini, Michela; Schaal, Benoist

2009-01-01

311

An Alternative View of the Instructional Design Process: A Response to Smith and Boling  

ERIC Educational Resources Information Center

A recent literature review by Smith and Boling (2009) critically examines the received view of instructional design in educational technology. Smith and Boling conclude that the foundational literature characterizes design in a way that leads to a constrained understanding of design, especially by novices. They suggest that as a field we move…

Gibbons, Andrew S.; Yanchar, Stephen C.

2010-01-01

312

Speech/Language Pathologists Reflect on Sally Smith and the Lab School of Washington  

ERIC Educational Resources Information Center

Sally L. Smith had a clear vision of how she thought speech and language services should be integrated into her school, The Lab School of Washington. It was Smith's idea that language therapists should work individually with students to help them make gains in their particular areas of need, as well as to work collaboratively with the teachers,…

Learning Disabilities: A Multidisciplinary Journal, 2010

2010-01-01

313

The Behavioural Phenotype of Smith-Magenis Syndrome: Evidence for a Gene-Environment Interaction  

ERIC Educational Resources Information Center

Background: Behaviour problems and a preference for adult contact are reported to be prominent in the phenotype of Smith-Magenis syndrome. In this study we examined the relationship between social interactions and self-injurious and aggressive/disruptive behaviour in Smith-Magenis syndrome to explore potential operant reinforcement of problem…

Taylor, L.; Oliver, C.

2008-01-01

314

Dyadic Power Theory, Touch, and Counseling Psychology: A Response to Smith, Vogel, Madon, and Edwards (2011)  

ERIC Educational Resources Information Center

Smith, Vogel, Madon, and Edwards' (2011) recent article tested dyadic power theory (DPT) by examining the use of touch as a compliance-gaining tactic in the conflicts of married couples. In this response, we raise a methodological issue about the touch behaviors examined by Smith et al. and also pose a theoretical critique that their test of DPT…

Dunbar, Norah E.; Abra, Gordon

2012-01-01

315

MR. smith's descriptions OP HTMENOPTEROUS INSECTS. 57 Descriptions of New Species of Hymenopterous Insects collected  

E-print Network

MR. smith's descriptions OP HTMENOPTEROUS INSECTS. 57 Descriptions of New Species of Hymenopterous Insects collected by Mr. A. R. "Wallace at Celebes. By Frederick Smith, Esq., Assistant in the Zoological Department of the British Museum. Communicated by "W. W. Saunders, Esq., E.R.S., V.P.L.S. [Read November 3

Villemant, Claire

316

Rhetorical image?making: A case study of the Thomas Paine?William Smith propaganda debates  

Microsoft Academic Search

Critics have long puzzled over the unexampled popular success of Thomas Paine's Common Sense and the corresponding failure of its most important reply, William Smith's Cato letters. In an attempt to account for this disparity, the author 1) explores how the interplay among goals, personal circumstances, means of argument, and style influenced the persuasive strategies of William Smith and Thomas

Thomas Clark

1975-01-01

317

CATEGORY/BUYER LISTING BUYERS: Darlene Smith, Richard Wagner Page 1  

E-print Network

AUTOMOBILE RENTAL JOHN MALONEY (614) 292-1405 AUTOS AUTOMOTIVE PARTS & SUPP: ANTIFREEZE, OIL, TIRES, SPARK RELATIONS, MARKETING, ADVERTISING AGENCY DARLENE SMITH (614) 688-8729 ADVER ADVERTISING: MEDIA, NEWSPAPER, RADIO, TV & DISPLAY/CLASSIFIED ADS DARLENE SMITH (614) 688-8729 AGRIC AGRIC IMPLEMENTS, PART/SUPP, FARM

Jones, Michelle

318

CATEGORY/BUYER LISTING BUYERS: Darlene Smith, Richard Wagner Page 1  

E-print Network

/TRUCK JOHN MALONEY (614) 292-1405 AUTOR AUTOMOBILE RENTAL JOHN MALONEY (614) 292-1405 AUTOS AUTOMOTIVE PARTS-3678 ADVAG ADVERTISING SVC.: PUBLIC RELATIONS, MARKETING, ADVERTISING AGENCY DARLENE SMITH (614) 688-8729 AGRIC AGRIC IMPLEMENTS, PART/SUPP, FARM EQUIPMENT, SUPPLIES & MAINTENANCE DARLENE SMITH (614) 688

Jones, Michelle

319

VIEW OF H.M. CAMP SMITH RECREATIONAL AREA, WITH MANANA HOUSING ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

VIEW OF H.M. CAMP SMITH RECREATIONAL AREA, WITH MANANA HOUSING AREA IN THE FAR LEFT DISTANCE. VIEW FACING EAST - Camp H.M. Smith and Navy Public Works Center Manana Title VII (Capehart) Housing, Intersection of Acacia Road and Brich Circle, Pearl City, Honolulu County, HI

320

Optimal server allocation typeset May 6, 2009 Smith, Cruz, & van Woensel Optimal Server Allocation in General,  

E-print Network

Optimal server allocation typeset May 6, 2009 Smith, Cruz, & van Woensel Optimal Server Allocation in General, Finite, Multi-Server Queueing Networks J. MacGregor Smith F. R. B. Cruz T. van Woensel jmsmith, mul- tiple servers, arbitrary acyclic, series-parallel topologies, and general service time

Cruz, Frederico

321

Terje Skjrpe Vibeke Videm, Anja Bye, Godfrey L. Smith, Sonia M. Najjar, yvind Ellingsen and  

E-print Network

Terje Skjærpe Vibeke Videm, Anja Bye, Godfrey L. Smith, Sonia M. Najjar, �yvind Ellingsen and Per, MSc; Godfrey L. Smith, PhD; Sonia M. Najjar, PhD; �yvind Ellingsen, MD, PhD; Terje Skjærpe, MD, Ph

Toledo, University of

322

James Anderson's Political Economy--His Influence on Smith and Malthus  

Microsoft Academic Search

James Anderson's powerful critique of Adam Smith's position on the corn export bounty was published in 1777. It focuse d on Smith's proposition that the bounty could not lead to increased corn production because it could not increase corn's real price. Smit h's response to the critique is traced in later editions of Wealth of Nations. While Anderson's critique of

Renee Prendergast

1987-01-01

323

2. VIEW OF THE SMITH NO.3 SITE ARE TO THE ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. VIEW OF THE SMITH NO.3 SITE ARE TO THE NORTHEAST. THE BLACKSMITH/MINE CAR REPAIR SHOP IS LEFT CENTER. THE PROCESSING PLANT AND TIPPLE ARE RIGHT CENTER. - Smith Mine, Bear Creek 1.5 miles West of Town of Bear Creek, Red Lodge, Carbon County, MT

324

NRES 725: Plant Physiological Ecology HO #43 From Hewitt & Smith (1975) Plant  

E-print Network

.008 #12;NRES 725: Plant Physiological Ecology HO #44 Fall 2008 From Hewitt & Smith (1975) Plant MineralNRES 725: Plant Physiological Ecology HO #43 Fall 2008 From Hewitt & Smith (1975) Plant Mineral Nutrition From Larcher (1995) Element name Symbol Plant content Plant requirements Soil content Nitrogen N

Nowak, Robert S.

325

From the Barrio to the Bucolic: The Student Transfer Experience from Hsis to Smith College  

ERIC Educational Resources Information Center

The study reported in this article examined two Hispanic-serving institutions, Miami-Dade Community College and Santa Monica College, and the innovative transfer agreements they have with Smith College, a highly selective private women's college. Factors that influence the successful transfer of women students to Smith from these HSIs are…

Wolf-Wendel, Lisa; Twombly, Susan; Morphew, Christopher; Sopcich, Joseph

2004-01-01

326

DR. BRIDGET R. SMITH-KONTER Department of Geological Sciences, University of Texas at El Paso  

E-print Network

-Konter Curriculum Vitae 1999 Undergraduate Research Asst., NASA Ames, NASA Academy · Statistical modeling-Bopp Morphology of HCN and CN in Comet Hale-Bopp SELECTED AWARDS AND HONORS *Awards prior to 2006 were awarded to B. Smith; all awards since 2007 have been awarded to B. Konter or B. Smith-Konter University

Smith-Konter, Bridget

327

DR. BRIDGET R. SMITH-KONTER Department of Geological Sciences, University of Texas at El Paso  

E-print Network

Asst., NASA Ames, NASA Academy · Statistical modeling of biological/chemical constraints-Bopp SELECTED AWARDS AND HONORS *Awards prior to 2006 were awarded to B. Smith; all awards since 2007 have been awarded to B. Konter or B. Smith-Konter University of Texas System Regents' Outstanding Teaching Award

Smith-Konter, Bridget

328

78 FR 6173 - Diana Del Grosso, Ray Smith, Joseph Hatch, Cheryl Hatch, Kathleen Kelley, Andrew Wilklund, and...  

Federal Register 2010, 2011, 2012, 2013

...Transportation Board [Docket No. FD 35652] Diana Del Grosso, Ray Smith, Joseph Hatch, Cheryl Hatch, Kathleen Kelley, Andrew...to a petition filed on August 1, 2012, by Diana Del Grosso, Ray Smith, Joseph Hatch, Cheryl Hatch, Kathleen Kelley,...

2013-01-29

329

THE USE OF RADIAL VELOCITY DERIVATIVE TO DIAGNOSE ROTATION AND DIVERGENCE Travis M. Smith1,2, *  

E-print Network

P5.6 THE USE OF RADIAL VELOCITY DERIVATIVE TO DIAGNOSE ROTATION AND DIVERGENCE Travis M. Smith1 was implemented in NSSL's Damaging Downburst Prediction and Detection Algorithm (Smith et al. 2004) for detecting

Smith, Travis

330

* Camera connections in Comm. Ctr and all digital equipment *Officers Currently in the FTO Program : Cody Smith  

E-print Network

: Cody Smith UPD Staff as of 9.5.13 Associate Director University Police Major Levelle 63 Assistant Graves 22 Officer Currie 68 Officer Smith 15 Officer Olivo Officer Mills Divisional Campuses Assistant

Mohaghegh, Shahab

331

Irish Astr. J., 27(1), XXXX, (2000) M. D. SMITH EVOLUTIONARY SCHEMES FOR PROTOSTARS, PROTO BROWN DWARFS  

E-print Network

Irish Astr. J., 27(1), XXXX, (2000) M. D. SMITH EVOLUTIONARY SCHEMES FOR PROTOSTARS, PROTO BROWN DWARFS AND THEIR ENVIRONMENTS M. D. SMITH Armagh Observatory, College Hill, Armagh, N. Ireland, BT61 9DG

332

Obituary: Harding Eugene (Gene) Smith, Jr., 1947-2007  

NASA Astrophysics Data System (ADS)

Harding Eugene Smith Junior, or Gene, as he was known to family, friends, and colleagues, passed away after an automobile accident in Encinitas, California, on 16 August 2007. He was 60 years old. Gene had recently retired from UCSD after thirty years of service. A memorial service was held at Quail Botanical Gardens in Encinitas, California, on 23 August 2007. A web page is dedicated to his memory at http://harding.smith.muchloved.com, where contributions of memories are invited. Gene was born in San Jose, California in 1947, to Harding Eugene Smith Senior, and Bernice Smith (nee Smith). Harding Smith Senior was an air-force navigator; therefore Gene spent his childhood moving from one air-force base to another. Although an only child, Gene was very close to his cousin Meg, whom he lived nearby to in Gilroy for a time, and the two were like brother and sister. The elder Harding Smith was lost in action over Cambodia in the mid-sixties. Gene was a dedicated student, a boy scout, and a Presidential Scholar. He majored in Physics at Caltech, where he also took a lively interest in the football team and the Glee Club, and was elected a House Officer. To his close friends, he was known at Caltech as Smitty, and the closest of them was Rob Drew, who gave a glimpse into that period of Gene's life at the memorial: "Gene arrived early at campus his first year, in response to an invitation to join the football team. Gene's size and features reminded the head coach of a long-forgotten player named 'Johnson.' After a few days of confusion, Gene simply replaced the name on his helmet. 'Johnson!' coach would yell, 'get in there!' If Johnson was going to get to play, Gene was going to be the best Johnson available!" Gene spent the summer of 1966 working at Kitt Peak, where his lifetime love of observing with ground-based telescopes began, though he learned some things the hard way, such as the fact that trying to squeeze 40,000 numbers onto a computer that stored only 32,000 resulted in blown fuses. In a final letter of that summer back to Drew he wrote: "My summer is now complete. I have achieved the highest pinnacle in my quest for fulfillment. Striking a blow for humanity I just blew the whole Kitt Peak CDC3200 computer system. Those fuses were nothing compared to this!" Gene's graduate work, on the metal abundances in HII regions of nearby galaxies, was done at Berkeley, where Hyron Spinrad was his thesis advisor. He loved observing and spent numerous fun nights at Lick, Kitt Peak, Cerro Tololo, Keck, and many other observatories. He joined Margaret Burbidge at UCSD for a postdoctoral fellowship, and joined the teaching faculty there in 1978. Gene spent his entire professional career at UCSD. His research ranged from the study of quasar absorptions lines to the astrophysics of Ultra-luminous Infrared Galaxies. He was a key participant in UC-wide astronomy support, including being the chair of the science-advisory committee for the Ten Meter Telescope project, which later "morphed" into the Keck Observatory. His contributions to enabling that project were both essential and unheralded. Gene was a dedicated and enthusiastic teacher. One of his favorite undergraduate classes gave him the opportunity to dress up in Renaissance garb and pretend to be Galileo, while the experiment most loved by his students was when they got to attempt to drop an egg on his head from several stories high. Gene was also an outstanding advisor and mentor, and both his first post-doc, Rick Puetter, and his last graduate student, Brian Siana, were able to attend his memorial service and provide some special memories of their experiences with him. Rick recalled a memorable trip to Cerro Tololo when they packed up two infrared spectrometers for the trip, and everything conceivable went wrong, from inspections at the airport to spectrometer parts broken on the plane and instrument failures at the observatory, to finally being completely clouded out. Brian recounted: "I spent countless cloudy nights listening to Gene's stories

Lonsdale, Carol; Soifer, Tom

2009-01-01

333

Allelic Variation in Malawi Cichlid Opsins: A Tale of Two Genera Adam R. Smith Karen L. Carleton  

E-print Network

Allelic Variation in Malawi Cichlid Opsins: A Tale of Two Genera Adam R. Smith · Karen L. Carleton speciation (Kornfield and Smith 2000; Danley and Kocher 2001; Gen- ner and Turner 2005). Lakes Malawi00239-010-9355-x) contains supplementary material, which is available to authorized users. A. R. Smith

Carleton, Karen L.

334

ASRF Visiting Senior Research Fellow Scheme The Adam Smith Research Foundation, based in the College of Social Sciences at the  

E-print Network

1 ASRF Visiting Senior Research Fellow Scheme The Adam Smith Research Foundation, based in the College of Social Sciences at the University of Glasgow, brings the Enlightenment legacy of Adam Smith these aims the Adam Smith Research Foundation invites applications for VISITING SENIOR RESEARCH FELLOWS

Guo, Zaoyang

335

Sophia Smith Collection: Population and Reproductive Health Oral History Project  

NSDL National Science Digital Library

Funded by the William and Flora Hewlett Foundation, the Population and Reproductive Health Oral History Project includes accounts of individuals throughout the world who have made valued contributions to the field. The materials here are part of the Women's History Archives at Smith College and the series includes the voices and perspectives of advocates, communication specialists, lawyers, managers, physicians, researchers, and social workers from the period 1965 to 2005. First-time visitors should read the Project History essay and then take a closer look at the several dozen interviews offered here. Those profiled here include the "mother of Asian demography," Mercedes Concepcion, and Lee Minto, the president of Planned Parenthood of Seattle-King County from 1967 to 1993. Other people interviewed here include Daniel E. Pellegrom, Nafis Sadik, and Sara Seims. It's a wonderful archive for persons interested in public health, women's studies, and a range of other crucial areas of academic study.

2013-05-16

336

Periventricular nodular heterotopia in Smith-Magenis syndrome.  

PubMed

Smith-Magenis syndrome (SMS) is caused by an interstitial microdeletion of chromosome 17p11.2. A few patients with the typical SMS phenotype have RAI1 gene mutations. The syndrome is characterized by minor craniofacial anomalies, short stature, sleep disturbances, behavioural and neurocognitive abnormalities, as well as variable multisystemic manifestations. Periventricular nodular heterotopia (PNH) is a genetically heterogeneous neuronal migration disorder characterized by subependymal heterotopic nodules, and is variably associated with other brain malformations, epileptic seizures and intellectual disability. Here we report on two patients harboring deletions of the 17p11.2 region in whom the SMS typical phenotype was associated with bilateral PNH. Our observations expand the spectrum of chromosomal rearrangements associated with PNH and indicate that abnormal neuronal migration may contribute to the neurocognitive phenotype of SMS. © 2014 Wiley Periodicals, Inc. PMID:25257626

Capra, Valeria; Biancheri, Roberta; Morana, Giovanni; Striano, Pasquale; Novara, Francesca; Ferrero, Giovanni Battista; Boeri, Luca; Celle, Maria Elena; Mancardi, Maria Margherita; Zuffardi, Orsetta; Parrini, Elena; Guerrini, Renzo

2014-12-01

337

Special Smith-Purcell radiation from an open resonator array  

NASA Astrophysics Data System (ADS)

An interesting new physical phenomenon is uncovered—an open resonator array excited by an electron beam and able to generate a special kind of Smith-Purcell radiation (SPR). Although the frequency and direction satisfy the SPR relation, this is a single frequency radiation in a specific direction that is essentially different from ordinary SPR. The spectral density of this special radiation is also much higher than that of ordinary SPR. By means of theoretical analysis and digital simulations, the radiation mechanism together with its requirements are explored. This radiation may have great influence in modern physics and optics as it offers new ways to carry out coherent radiation generation and beam diagnostics.

Liu, Weihao; Xu, Zhengyuan

2014-07-01

338

Mission Specialist Smith is suited and ready for launch  

NASA Technical Reports Server (NTRS)

In the Operations and Checkout Building, STS-103 Mission Specialist Steven L. Smith signals he is suited up and ready for launch. Other crew members are Commander Curtis L. Brown Jr., Pilot Scott J. Kelly and Mission Specialists C. Michel Foale (Ph.D.), John M. Grunsfeld (Ph.D.), Jean-Frangois Clervoy of France and Claude Nicollier of Switzerland. Clervoy and Nicollier are with the European Space Agency. The STS-103 mission, to service the Hubble Space Telescope, is scheduled for launch Dec. 17 at 8:47 p.m. EST from Launch Pad 39B. Mission objectives include replacing gyroscopes and an old computer, installing another solid state recorder, and replacing damaged insulation in the telescope. After the 8-day, 21-hour mission, Discovery is expected to land at KSC Sunday, Dec. 26, at about 6:30 p.m. EST.

1999-01-01

339

The analysis of convolutional codes via the extended Smith algorithm  

NASA Technical Reports Server (NTRS)

Convolutional codes have been the central part of most error-control systems in deep-space communication for many years. Almost all such applications, however, have used the restricted class of (n,1), also known as 'rate 1/n,' convolutional codes. The more general class of (n,k) convolutional codes contains many potentially useful codes, but their algebraic theory is difficult and has proved to be a stumbling block in the evolution of convolutional coding systems. In this article, the situation is improved by describing a set of practical algorithms for computing certain basic things about a convolutional code (among them the degree, the Forney indices, a minimal generator matrix, and a parity-check matrix), which are usually needed before a system using the code can be built. The approach is based on the classic Forney theory for convolutional codes, together with the extended Smith algorithm for polynomial matrices, which is introduced in this article.

Mceliece, R. J.; Onyszchuk, I.

1993-01-01

340

Analysis of Smith-Purcell free-electron lasers.  

PubMed

We present an analysis of the beam dynamics in a Smith-Purcell free-electron laser (FEL). In this system, an electron beam interacts resonantly with a copropagating surface electromagnetic mode near the grating surface. The surface mode arises as a singularity in the frequency dependence of the reflection matrix. Since the surface mode is confined very close to the grating surface, the interaction is significant only if the electrons are moving very close to the grating surface. The group velocity of the surface mode resonantly interacting with a low-energy electron beam is in the direction opposite to the electron beam. The Smith-Purcell FEL is therefore a backward wave oscillator in which, if the beam current exceeds a certain threshold known as start current, the optical intensity grows to saturation even if no mirrors are employed for feedback. We derive the coupled Maxwell-Lorentz equations for describing the interaction between the surface mode and the electron beam, starting from the slowly varying approximation and the singularity in the reflection matrix. In the linear regime, we derive an analytic expression for the start current and calculate the growth rate of optical power in time. The analysis is extended to the nonlinear regime by performing a one-dimensional time-dependent numerical simulation. Results of our numerical calculation compare well with the analytic calculation in the linear regime and show saturation behavior in the nonlinear regime. We find that a significant amount of power grows in the surface mode due to this interaction. Several ways to outcouple this power to freely propagating modes are discussed. PMID:16605464

Kumar, Vinit; Kim, Kwang-Je

2006-02-01

341

Smith college secondary math and science outreach program  

SciTech Connect

The Smith College Secondary Math and Science Outreach Program works collaboratively with front-line educators to encourage young women students of all abilities, especially underrepresented and underserved minorities, to continue studying math and science throughout high school. The program includes three main components: (1) Twenty-five to thirty teams of math/science teachers and guidance counselors participate in a year-long program which begins with a three-day Current Students/Future Scientists and Engineering Workshop. This event includes a keynote address, presentations and workshops by successful women in science and engineering, and hands-on laboratory sessions. Each participant receives a stipend and free room and board. Returning to their schools, the teacher-counselor teams implement ongoing plans designed to counteract gender bias in the sciences and to alert female students to the broad range of math, science, and engineering career choices open to them. A follow-up session in the spring allows the teams to present and discuss their year-long activities. (2) TRI-ON, a day of science for 120 ninth- and tenth- grade girls from schools with a large underserved and underrepresented population, is held in early spring. Girls discover the excitement of laboratory investigation and interact with female college science and math majors. (3) Teaching Internships, initiated in 1991, involve ten to fifteen Smith College math and science majors in teaching in public schools. The teaching interns experience the rewards and challenges of classroom teaching, and they also serve as role models for younger students.

Powell, J.A.; Clark, C. [Smith College, Northhampton, MA (United States)

1994-12-31

342

A local construction of the Smith normal form of a matrix polynomial  

SciTech Connect

We present an algorithm for computing a Smith form with multipliers of a regular matrix polynomial over a field. This algorithm differs from previous ones in that it computes a local Smith form for each irreducible factor in the determinant separately and then combines them into a global Smith form, whereas other algorithms apply a sequence of unimodular operations to the original matrix row by row (or column by column). The performance of the algorithm in exact arithmetic is reported for several test cases.

Wilkening, Jon; Yu, Jia

2008-09-01

343

Comments on the "Proof of the atmospheric greenhouse effect" by Arthur B. Smith  

E-print Network

In this paper it is shown that Smith (2008) used inappropriate and inconsistent formulations in averaging various quantities over the entire surface of the Earth considered as a sphere. Using two instances of averaging procedures as customarily applied in studies on turbulence, it is shown that Smith's formulations are highly awkward. Furthermore, Smith's discussion of the infrared absorption in the atmosphere is scrutinized and evaluated. It is shown that his attempt to refute the criticism of Gerlich and Tscheuschner (2007, 2009) on the so-called greenhouse effect is rather fruitless.

Kramm, Gerhard; Zelger, Michael

2009-01-01

344

Interview: European collaboration in relative effectiveness assessment: the use of patient registries and development of common guidelines.  

PubMed

Wim Goettsch is currently the Project Leader of Work Package 5 of the European Network of Health Technology Assessment (EUnetHTA) Joint Action 2 (2012-2015). EUnetHTA is a network of the health technology assessment organizations in Europe responsible for advising or deciding on the national reimbursement of pharmaceuticals and other health technologies. In this work package, rapid joint assessments of the relative effectiveness of pharmaceuticals are piloted between more than 25 health technology assessment organizations around Europe. These pilots are based on the methodology that was developed in a similar work package in EUnetHTA JA1 (2010-2012), of which Dr Goettsch was also the Project Leader. Until the beginning of 2013, Dr Goettsch was the Deputy Secretary of the Medicinal Products Reimbursement Committee at Dutch Healthcare Insurance Board (CVZ). The Dutch Medicinal Products Reimbursement Committee advises the Dutch Minister of Health on whether new drugs need to be included in the basic insurance package. Before joining CVZ, he worked as a research manager for the PHARMO Institute (Utrecht, The Netherlands) and was responsible for the coordination of numerous pharmacoepidemiological and outcomes studies for international offices of pharmaceutical companies, such as AstraZeneca, Novartis, Pfizer and GlaxoSmithKline. Dr Goettsch has approximately 50 publications in peer-reviewed international journals. PMID:24236677

Goettsch, Wim

2013-07-01

345

Mining Natural-Products Screening Data for Target-Class Chemical Motifs.  

PubMed

In this article, we describe two complementary data-mining approaches used to characterize the GlaxoSmithKline (GSK) natural-products set (NPS) based on information from the high-throughput screening (HTS) databases. Both methods rely on the aggregation and analysis of a large set of single-shot screening data for a number of biological assays, with the goal to reveal natural-product chemical motifs. One of them is an established method based on the data-driven clustering of compounds using a wide range of descriptors,(1) whereas the other method partitions and hierarchically clusters the data to identify chemical cores.(2,3) Both methods successfully find structural scaffolds that significantly hit different groups of discrete drug targets, compared with their relative frequency of demonstrating inhibitory activity in a large number of screens. We describe how these methods can be applied to unveil hidden information in large single-shot HTS data sets. Applied prospectively, this type of information could contribute to the design of new chemical templates for drug-target classes and guide synthetic efforts for lead optimization of tractable hits that are based on natural-product chemical motifs. Relevant findings for 7TM receptors (7TMRs), ion channels, class-7 transferases (protein kinases), hydrolases, and oxidoreductases will be discussed. PMID:24518065

Coma, Isabel; Bandyopadhyay, Deepak; Diez, Emilio; Ruiz, Emilio Alvarez; de Los Frailes, Maria Teresa; Colmenarejo, Gonzalo

2014-02-11

346

Identification and Characterization of Hundreds of Potent and Selective Inhibitors of Trypanosoma brucei Growth from a Kinase-Targeted Library Screening Campaign  

PubMed Central

In the interest of identification of new kinase-targeting chemotypes for target and pathway analysis and drug discovery in Trypanosomal brucei, a high-throughput screen of 42,444 focused inhibitors from the GlaxoSmithKline screening collection was performed against parasite cell cultures and counter-screened against human hepatocarcinoma (HepG2) cells. In this way, we have identified 797 sub-micromolar inhibitors of T. brucei growth that are at least 100-fold selective over HepG2 cells. Importantly, 242 of these hit compounds acted rapidly in inhibiting cellular growth, 137 showed rapid cidality. A variety of in silico and in vitro physicochemical and drug metabolism properties were assessed, and human kinase selectivity data were obtained, and, based on these data, we prioritized three compounds for pharmacokinetic assessment and demonstrated parasitological cure of a murine bloodstream infection of T. brucei rhodesiense with one of these compounds (NEU-1053). This work represents a successful implementation of a unique industrial-academic collaboration model aimed at identification of high quality inhibitors that will provide the parasitology community with chemical matter that can be utilized to develop kinase-targeting tool compounds. Furthermore these results are expected to provide rich starting points for discovery of kinase-targeting tool compounds for T. brucei, and new HAT therapeutics discovery programs. PMID:25340575

Diaz, Rosario; Luengo-Arratta, Sandra A.; Seixas, João D.; Amata, Emanuele; Devine, William; Cordon-Obras, Carlos; Rojas-Barros, Domingo I.; Jimenez, Elena; Ortega, Fatima; Crouch, Sabrinia; Colmenarejo, Gonzalo; Fiandor, Jose Maria; Martin, Jose Julio; Berlanga, Manuela; Gonzalez, Silvia; Manzano, Pilar; Navarro, Miguel; Pollastri, Michael P.

2014-01-01

347

Prediction of Pneumococcal Conjugate Vaccine Effectiveness against Invasive Pneumococcal Disease Using Opsonophagocytic Activity and Antibody Concentrations Determined by Enzyme-Linked Immunosorbent Assay with 22F Adsorption ?  

PubMed Central

We compared the abilities of two serological readouts, antipolysaccharide IgG antibody concentrations and opsonophagocytic activity (OPA) titers, to predict the clinical effectiveness of the 7-valent pneumococcal conjugate vaccine (7vCRM) against invasive pneumococcal disease (IPD). We also assessed the accuracy of the previously established thresholds for GlaxoSmithKline's enzyme-linked immunosorbent assay with 22F adsorption (22F-ELISA) (?0.2 ?g/ml) and OPA assay (titer, ?8) in predicting effectiveness. We showed that following a 3-dose 7vCRM primary vaccination, the serological response rates as determined using thresholds of ?0.2 ?g/ml IgG and an OPA titer of ?8 corresponded well with overall effectiveness against IPD. In addition, the OPA assay seemed to better predict serotype-specific effectiveness than enzyme-linked immunoassay. Finally, when applied to post-dose-2 immune responses, both thresholds also corresponded well with the overall IPD effectiveness following a 2-dose 7vCRM primary vaccination. These results support the importance of the OPA assay in evaluating immune responses to pneumococcal conjugate vaccines. PMID:21994351

Schuerman, L.; Wysocki, J.; Tejedor, J. C.; Knuf, M.; Kim, K.-H.; Poolman, J.

2011-01-01

348

Keystone Symposium on Antibodies as Drugs  

PubMed Central

The symposium on Antibodies as Drugs, organized by Keystone Symposia and chaired by J. Marks, (University of California Los Angeles, USA), E.S. Ward (University of Texas Southwestern Medical Center, USA) and L. Weiner (Georgetown University Medical Center, USA), was held in Whistler, British Columbia. This Canadian Rockies village, which will host the 2010 Olympic Games, served as an enchanting backdrop to the meeting. The more than 350 speakers and attendees included scientists from major pharmaceutical firms, e.g., Abbott, MedImmune/Astra Zeneca, Bristol-Myers Squibb, Merck & Co., Pfizer, Sanofi-Aventis, Schering, GlaxoSmithKline, Eli Lilly, Hoffmann LaRoche, Novartis, Wyeth, and biotechnology companies, e.g., Ablynx, Medarex, Morphosys, GenMab, Amgen, Genentech, ImmunoGen, Agensys, Domantis, Biogen Idec, Centocor, LFB, Micromet, PDL Biopharma, Borean Pharma, Dyax Corp., Symphogen and Syntonix. Academic research groups at Imperial College London, University of Oxford, ETH Zürich, Scripps, Institute Cochin, Karolinska Institute, Utrecht University, Harvard Medical School, Massachusetts Institute of Technology, Baylor College, Paul Ehrlich Institute, University of California San Francisco, University of California San Diego, University of Nantes, University of Tours and Ludwig Institute were also represented, as were regulatory authorities, including the US Food and Drug Administration, National Institutes of Health and the Public Health Agency of Canada). The meeting was very interactive and included thoughtful exchanges during the different sessions and networking events. PMID:20068403

Larbouret, Christel; Robert, Bruno

2009-01-01

349

Preclinical efficacy of MEK inhibition in Nras-mutant AML  

PubMed Central

Oncogenic NRAS mutations are highly prevalent in acute myeloid leukemia (AML). Genetic analysis supports the hypothesis that NRAS mutations cooperate with antecedent molecular lesions in leukemogenesis, but have limited independent prognostic significance. Using short hairpin RNA–mediated knockdown in human cell lines and primary mouse leukemias, we show that AML cells with NRAS/Nras mutations are dependent on continued oncogene expression in vitro and in vivo. Using the Mx1-Cre transgene to inactivate a conditional mutant Nras allele, we analyzed hematopoiesis and hematopoietic stem and progenitor cells (HSPCs) under normal and stressed conditions and found that HSPCs lacking Nras expression are functionally equivalent to normal HSPCs in the adult mouse. Treating recipient mice transplanted with primary NrasG12D AMLs with 2 potent allosteric mitogen-activated protein kinase kinase (MEK) inhibitors (PD0325901 or trametinib/GlaxoSmithKline 1120212) significantly prolonged survival and reduced proliferation but did not induce apoptosis, promote differentiation, or drive clonal evolution. The phosphatidylinositol 3-kinase inhibitor GDC-0941 was ineffective as a single agent and did not augment the activity of PD0325901. All mice ultimately succumbed to progressive leukemia. Together, these data validate oncogenic N-Ras signaling as a therapeutic target in AML and support testing combination regimens that include MEK inhibitors. PMID:25361812

Burgess, Michael R.; Hwang, Eugene; Firestone, Ari J.; Huang, Tannie; Xu, Jin; Zuber, Johannes; Bohin, Natacha; Wen, Tiffany; Kogan, Scott C.; Haigis, Kevin M.; Sampath, Deepak; Lowe, Scott; Shannon, Kevin

2014-01-01

350

Once-weekly albiglutide in the management of type 2 diabetes: patient considerations  

PubMed Central

This review describes the pharmacologic, pharmacokinetic, and pharmacodynamic properties of albiglutide, as well as its clinical efficacy and safety. Albiglutide is a novel, once-weekly, injectable glucagon-like peptide-1 receptor agonist for the treatment of type 2 diabetes. The European Commission recently granted marketing authorization for the drug in the European Union and on April 15, 2014, the US Food and Drug Administration approved albiglutide (Tanzeum™ [GlaxoSmithKline LLC, Wilmington, DE, USA]) to improve glycemic control in adults with type 2 diabetes. Albiglutide has been studied in Phase I, II, and III clinical trials. In the Phase III clinical trials, known as the Harmony series, weekly dosing of albiglutide demonstrated reductions in fasting plasma glucose, postprandial plasma glucose, and glycated hemoglobin, and was associated with weight loss. In all phases of the clinical trials, albiglutide administered once weekly showed a safety and tolerability profile similar to that of placebo, with mild gastrointestinal-related complaints and injection site erythema being the most commonly encountered adverse effects. Compared with pioglitazone and liraglutide, albiglutide has been shown to be clinically less effective. However, it offers the benefit of weight loss that pioglitazone does not, with fewer gastrointestinal side effects than liraglutide. As guidelines continue to advocate for patient-centered treatment strategies, once-weekly albiglutide will be an important addition to the growing armamentarium of treatment options for adults with type 2 diabetes needing target glycemic control. PMID:24926194

Woodward, Heather N; Anderson, Sarah L

2014-01-01

351

[The malaria vaccine candidate RTS,S/AS is in phase III clinical trials].  

PubMed

This review paper describes the development of the RTS,S/AS vaccine, from concept to phase III testing. The rationale for selection of the circumsporozoite protein (CSP) as the target antigen and the preclinical development history of the vaccine are described. The RTS,S/AS candidate vaccine has been evaluated in multiple phase I/II studies and was shown to have a favorable safety profile and to be well tolerated in both adults and children. Consistent and significant efficacy has been observed in the target population of infants and children against Plasmodium falciparum infection and disease in different transmission settings, in different age groups, with or without Expanded Program of Immunization (EPI) vaccine co-administration. The RTS,S/AS01(E) malaria vaccine candidate has recently entered phase III testing. Reaching this important milestone is the culmination of more than 20 years of research and development by GlaxoSmithKline, their partners and collaborators. If the phase III results confirm the observations made during phase II testing, the RTS,S/AS01(E) vaccine, when broadly implemented and judiciously integrated with other malaria-prevention measures, would have a major public-health impact in sub-Saharan Africa. PMID:21073995

Cohen, J; Benns, S; Vekemans, J; Leach, A

2010-11-01

352

A small molecule FAK kinase inhibitor, GSK2256098, inhibits growth and survival of pancreatic ductal adenocarcinoma cells.  

PubMed

Focal adhesion kinase (FAK) hyperactivation is common in pancreatic ductal adenocarcinoma (PDAC). A small molecule, GSK2256098 (GlaxoSmithKline), has been developed to inhibit FAK activity through targeting the phosphorylation site of FAK, tyrosine (Y) 397. We sought to determine whether GSK2256098 inhibition of FAK Y397 phosphorylation attenuates PDAC-associated cell proliferation, motility and survival. Cultured PDAC cells were used as cellular models of GSK2256098-impaired abnormal growth. Western blot analysis, cell viability analysis, clonogenic survival, soft-agar and wound healing assays were performed. The responses of 6 PDAC cell lines in regards to FAK Y397 phosphorylation or activity to GSK2256098 treatments (0.1-10 ?M) ranged from low (less than 20% inhibition) to high (more than 90% inhibition). The least and most sensitive cell lines (PANC-1 and L3.6P1) were selected for further analysis. GSK2256098 inhibition of FAK Y397 phosphorylation correlated with decreased levels of phosphorylated Akt and ERK in L3.6P1 cells. GSK2256098 decreased cell viability, anchorage-independent growth, and motility in a dose dependent manner. Current studies demonstrate that small molecule kinase inhibitors targeting FAK Y397 phosphorylation can inhibit PDAC cell growth. Assessments of FAK Y397 phosphorylation in biopsies may be used as a biomarker to select the subgroup of responsive patients and/or monitor the effects of GSK2256098 on FAK-modulated tumor growth during treatment. PMID:25486573

Zhang, Jianliang; He, Di-Hua; Zajac-Kaye, Maria; Hochwald, Steven N

2014-01-01

353

Assessment of acceptability and ease of use of atovaquone/proguanil medication in subjects undergoing malaria prophylaxis  

PubMed Central

Objective: International travelers from non-endemic areas are at high risk of contracting malaria due to their lack of immunity. Prevention is therefore of outmost importance and is achieved through effective and safe chemoprophylaxis, which reduces the risk of fatal disease. Among the various antimalarial drugs available, the synergistic combination of atovaquone and proguanil (A/P) (Malarone®; Glaxo-SmithKline) has proven a valuable option in terms of effective protection against chloroquine and multi-drug resistant falciparum malaria, safety, tolerability, and ease of use, thus favoring compliance. The purpose of the present study was to assess acceptability and ease of use of A/P chemoprophylaxis in a population of employees of the oil industry bound to malarious areas. Particular attention was paid to treatment adherence. Methods: A survey was conducted on a sample of 700 employees on A/P chemoprophylaxis. Demographic data and specific information on A/P treatment were collected by means of a 16-item questionnaire administered immediately before departure. All questionnaires returned were then entered into a database and statistically analyzed. Results: Both habitual and first-time travelers showed good adherence to A/P chemoprophylactic regimen. In general, only few adverse side-effects were reported, none of which were serious. Travelers with previous experience of other antimalarials stated A/P prophylaxis had proven advantageous due to fewer adverse reactions, better condition of administration, and better sense of protection compared with other available treatments. PMID:19209290

Nicosia, V; Colombo, Giorgio; Consentino, M; Di Matteo, S; Mika, F; De Sanctis, S; Ratti, S; Vinci, Marta

2008-01-01

354

Gabapentin enacarbil, a gabapentin prodrug for the treatment of the neurological symptoms associated with disorders such as restless legs syndrome.  

PubMed

Restless Legs Syndrome (RLS) is a sleep-related movement disorder characterized by an urge to move the legs accompanied by unpleasant symptoms. Dopaminergic agents currently represent the first-line therapy for RLS. However, some patients are unable to continue with this pharmacological approach in the long term because of augmentation or other adverse events. Limited studies with the anticonvulsant/analgesic agent gabapentin have demonstrated that this drug might be useful in the treatment of primary and uremic RLS. Unfortunately, gabapentin has an unfavorable pharmacokinetic profile characterized by a dose-dependent bioavailability. Gabapentin enacarbil, a prodrug of gabapentin, is currently being developed by XenoPort Inc/Astellas Pharma Inc/GlaxoSmithKline plc in order to overcome this limitation. In vitro and in vivo studies have demonstrated that gabapentin enacarbil provides a dose-proportional exposure to gabapentin when orally administered. Gabapentin enacarbil has proved to be beneficial in treating RLS symptoms in several phase II and III clinical trials. In addition, these trials have demonstrated that gabapentin enacarbil is safe and well tolerated, causing transient and mild or moderate adverse events. Gabapentin enacarbil is an interesting compound, which is potentially useful in treating RLS patients who report severe adverse events under dopaminergic agents. The author concludes that additional studies are required in order to better assess the efficacy and safety of gabapentin enacarbil on RLS. PMID:19127491

Merlino, Giovanni; Serafini, Anna; Young, Jeong Jin; Robiony, Francesca; Gigli, Gian Luigi; Valente, Mariarosaria

2009-01-01

355

Mechanisms of Acquired Resistance to Tyrosine Kinase Inhibitors in Clear - Cell Renal Cell Carcinoma (ccRCC).  

PubMed

Clear - cell renal cell carcinoma (ccRCC) is a histological subtype of renal cell carcinoma - the most prevalent adult kidney cancer. Causes of ccRCC are not completely understood and therefore number of available therapies is limited. As a consequence of tumor chemo- and radioresistance as well as restrictions in offered targeted therapies, overall response rate is still unsatisfactory. Moreover, a significant group of patients (circa 1/4) does not respond to the targeted first-line treatment, while in other cases, after an initial period of stable improvement, disease progression occurs. Owing to this, more data on resistance mechanisms are needed, especially those concerning widely used, relatively lately approved and more successful than previous therapies - tyrosine kinase inhibitors (TKIs). Up to date, five TKIs have been licensed for ccRCC treatment: sunitinib (SUTENT(®), Pfizer Inc.), sorafenib (Nexavar(®), Bayer HealthCare/Onyx Pharmaceuticals), pazopanib (Votrient(®), GlaxoSmithKline), axitinib (Inlyta(®), Pfitzer Inc.) and tivozanib (AV-951(®), AVEO Pharmaceuticals). Researchers have specified different subsets of tyrosine kinase inhibitors potential resistance mechanisms in clear-cell renal cell carcinoma. In most papers published until now, drug resistance is divided into intrinsic and acquired, and typically multi-drug resistance (MDR) protein is described. Herein, the authors focus on molecular analysis concerning acquired, non-genetic resistance to TKIs, with insight into specific biological processes. PMID:25152704

Bielecka, Zofia F; Czarnecka, Anna M; Solarek, Wojciech; Kornakiewicz, Anna; Szczylik, Cezary

2014-12-01

356

New antiepileptic medication linked to blue discoloration of the skin and eyes.  

PubMed

Ezogabine is an antiepileptic medication approved in June 2011 by the US Food and Drug Administration (FDA) as an adjunctive treatment for partial seizures. Minimal drug interactions and a novel mechanism of action made ezogabine an appealing new treatment option. However, adverse effects reported during clinical trials and following drug approval have been alarming. A Risk Evaluation Mitigation Strategy (REMS) program has been established for urinary retention. A safety alert was published in April 2013 warning ezogabine may cause retinal pigment abnormalities and/or blue-gray discoloration, most notably on or near the lips, nail beds, sclera and conjunctiva with long-term use. In October 2013, the FDA announced a formal label change to ezogabine to include a black boxed warning emphasizing the previously reported warnings of eye and skin discoloration and permanent vision changes. Given the unknown nature of the pathophysiology, consequences and potential for reversibility of these effects, GlaxoSmithKline and the FDA have published recommendations for patients currently receiving ezogabine. Further data from published case reports and long-term safety trials in the future may lend additional insight into these concerning effects. PMID:25642319

Clark, Sarah; Antell, Alexandra; Kaufman, Kimberly

2015-02-01

357

[Narcolepsy with cataplexy: an autoimmune disease?].  

PubMed

Narcolepsy type 1 (also named narcolepsy-cataplexy or hypocretin deficiency syndrome) is a rare sleep disorder characterized by excessive daytime sleepiness and cataplexy, plus frequently hypnagogic hallucinations, sleep paralysis and nocturnal sleep disturbances. Narcolepsy type 1 is an immune system-associated disease linked with the destruction of 70.000-90.000 hypocretin neurons notably involved in wakefulness. Among narcoleptic patients, 98% are positive for HLA-DQB1*06:02, a HLA class II allele, against 20-25% in general population. Individuals carrying HLA-DQB1*06:02 have an extraordinary risk to develop narcolepsy (odd ratio: 251). Other genes involved in CD4+ T cells and immune system activation as T-cell receptor ? are also associated with narcolepsy. The development of the disease is linked with environmental factors such as influenza and streptococcal infections. Narcolepsy type 1 incidence also increased in Europe following the use of Pandemrix, a 2009 H1N1 AS03-adjuvanted vaccine manufactured by GlaxoSmithKline. Interestingly, such increase was not observed with Arepanrix, another vaccine developed by GSK very similar to Pandemrix. PMID:25537044

Jacob, Louis; Dauvilliers, Yves

2014-12-01

358

Target Prediction for an Open Access Set of Compounds Active against Mycobacterium tuberculosis  

PubMed Central

Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), infects an estimated two billion people worldwide and is the leading cause of mortality due to infectious disease. The development of new anti-TB therapeutics is required, because of the emergence of multi-drug resistance strains as well as co-infection with other pathogens, especially HIV. Recently, the pharmaceutical company GlaxoSmithKline published the results of a high-throughput screen (HTS) of their two million compound library for anti-mycobacterial phenotypes. The screen revealed 776 compounds with significant activity against the M. tuberculosis H37Rv strain, including a subset of 177 prioritized compounds with high potency and low in vitro cytotoxicity. The next major challenge is the identification of the target proteins. Here, we use a computational approach that integrates historical bioassay data, chemical properties and structural comparisons of selected compounds to propose their potential targets in M. tuberculosis. We predicted 139 target - compound links, providing a necessary basis for further studies to characterize the mode of action of these compounds. The results from our analysis, including the predicted structural models, are available to the wider scientific community in the open source mode, to encourage further development of novel TB therapeutics. PMID:24098102

Martínez-Jiménez, Francisco; Papadatos, George; Yang, Lun; Wallace, Iain M.; Kumar, Vinod; Pieper, Ursula; Sali, Andrej; Brown, James R.; Overington, John P.; Marti-Renom, Marc A.

2013-01-01

359

New antiepileptic medication linked to blue discoloration of the skin and eyes  

PubMed Central

Ezogabine is an antiepileptic medication approved in June 2011 by the US Food and Drug Administration (FDA) as an adjunctive treatment for partial seizures. Minimal drug interactions and a novel mechanism of action made ezogabine an appealing new treatment option. However, adverse effects reported during clinical trials and following drug approval have been alarming. A Risk Evaluation Mitigation Strategy (REMS) program has been established for urinary retention. A safety alert was published in April 2013 warning ezogabine may cause retinal pigment abnormalities and/or blue-gray discoloration, most notably on or near the lips, nail beds, sclera and conjunctiva with long-term use. In October 2013, the FDA announced a formal label change to ezogabine to include a black boxed warning emphasizing the previously reported warnings of eye and skin discoloration and permanent vision changes. Given the unknown nature of the pathophysiology, consequences and potential for reversibility of these effects, GlaxoSmithKline and the FDA have published recommendations for patients currently receiving ezogabine. Further data from published case reports and long-term safety trials in the future may lend additional insight into these concerning effects. PMID:25642319

Antell, Alexandra; Kaufman, Kimberly

2015-01-01

360

James E. Smith J.B. Fuqua Professor of Business Administration  

E-print Network

University. He teaches courses in probability and statistics and decision modeling. Professor Smith supported by grants from the National Science Foundation, Chevron, and the Eli Lilly Foundation. In 2008

Reif, John H.

361

Adam Smith's rhetorical sympathy: a return of moral sentiments to public policy  

E-print Network

Since Adam Smith's highly successful Wealth of Nations, most scholarship built on his work has been economic in scope and has ignored the greater implications of his contribution to policy-making. This thesis examines the role moral sentiment...

Gore, David Charles

2012-06-07

362

University of California: In Memoriam, 1959 Page 1 of 2 Harry Scott Smith, Biological Control: Riverside  

E-print Network

of Expert. His first assignment was a study of the parasites of the boll weevil in the southern states Professor Smith was sent to Europe to obtain natural enemies of the destructive alfalfa weevil. Headquarters

Hoddle, Mark S.

363

Camp H.M. Smith and Navy Public Works Center Manana Title ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Camp H.M. Smith and Navy Public Works Center Manana Title VII (Capehart) Housing, U-Shaped Three-Bedroom Duplex Type 4, Acacia Road, Birch Circle, Cedar Drive and Elm Drive, Pearl City, Honolulu County, HI

364

78 FR 16286 - Neal Smith National Wildlife Refuge, Jasper County, IA; Final Comprehensive Conservation Plan and...  

Federal Register 2010, 2011, 2012, 2013

...Significant Impact for Environmental Assessment AGENCY: Fish and Wildlife...finding of no significant impact (FONSI) for the Environmental Assessment (EA) for Neal Smith...by any of the following methods: Email:...

2013-03-14

365

Paul Edward Smith Department of Biochemistry, 36 Willard Hall, Kansas State University  

E-print Network

Paul Edward Smith Department of Biochemistry, 36 Willard Hall, Kansas State University Manhattan, 1985 Research Experience Assistant Professor, 1996 to present, Department of Biochemistry, Kansas State University, Manhattan, Kansas. Research Assistant Professor, 1993 to 1996, Department of Chemistry

Smith, Paul E.

366

Evolutionary consequences of dispersal ability in cactus-feeding insects Christopher Irwin Smith1,2,  

E-print Network

Evolutionary consequences of dispersal ability in cactus-feeding insects Christopher Irwin Smith1 and macroevolutionary patterns; this prediction is borne out by comparisons of species diversity in cactus

Farrell, Brian D.

367

Measuring short electron bunch lengths using coherent Smith-Purcell radiation  

DOEpatents

A method is provided for directly determining the length of sub-picosecond electron bunches. A metallic grating is formed with a groove spacing greater than a length expected for the electron bunches. The electron bunches are passed over the metallic grating to generate coherent and incoherent Smith-Purcell radiation. The angular distribution of the coherent Smith-Purcell radiation is then mapped to directly deduce the length of the electron bunches. 8 figs.

Nguyen, D.C.

1999-03-30

368

IMC based automatic tuning method for PID controllers in a Smith predictor configuration  

Microsoft Academic Search

In this paper, a new approach is presented based on relay autotuning of a plant to find parameters for its control using a Smith predictor. A Smith predictor configuration is represented as its equivalent internal model controller (IMC) which provides the parameters of the proportional-integral (PI) or proportional-integral-derivative (PID) controller to be defined in terms of the desired closed-loop time

Ibrahim Kaya

2004-01-01

369

160-fold acceleration of the Smith-Waterman algorithm using a field programmable gate array (FPGA)  

Microsoft Academic Search

BACKGROUND: To infer homology and subsequently gene function, the Smith-Waterman (SW) algorithm is used to find the optimal local alignment between two sequences. When searching sequence databases that may contain hundreds of millions of sequences, this algorithm becomes computationally expensive. RESULTS: In this paper, we focused on accelerating the Smith-Waterman algorithm by using FPGA-based hardware that implemented a module for

Isaac T. S. Li; Warren Shum; Kevin Truong

2007-01-01

370

An optimal control approach to pilot/vehicle analysis and Neal-Smith criteria  

NASA Technical Reports Server (NTRS)

The approach of Neal and Smith was merged with the advances in pilot modeling by means of optimal control techniques. While confirming the findings of Neal and Smith, a methodology that explicitly includes the pilot's objective in attitude tracking was developed. More importantly, the method yields the required system bandwidth along with a better pilot model directly applicable to closed-loop analysis of systems in any order.

Bacon, B. J.; Schmidt, D. K.

1984-01-01

371

Francis H. Smith: architect of antebellum southern military schools and educational reform  

E-print Network

with many excellent ideas. Two VMI alumni also deserve special thanks: Colonel Alexander Henderson Morrison (’39) and Colonel William Mayo Smith (’38), both great-grandsons of Francis H. Smith who offered me many useful family sources to tell the story...………………………………………………………………………………… 441 ix LIST OF TABLES TABLE Page 1 Enrollment by Class at the Virginia Military Institute (Classes 1842 – 1862)…………………………………………………… 168 2 VMI Cadets and Prestigious Relatives, 1842-1862...

Wineman, Bradford Alexander

2006-10-30

372

The Futility of Utility: how market dynamics marginalize Adam Smith  

E-print Network

Econometrics is based on the nonempiric notion of utility. Prices, dynamics, and market equilibria are supposed to be derived from utility. Utility is usually treated by economists as a price potential, other times utility rates are treated as Lagrangians. Assumptions of integrability of Lagrangians and dynamics are implicitly and uncritically made. In particular, economists assume that price is the gradient of utility in equilibrium, but I show that price as the gradient of utility is an integrability condition for the Hamiltonian dynamics of an optimization problem in econometric control theory. One consequence is that, in a nonintegrable dynamical system, price cannot be expressed as a function of demand or supply variables. Another consequence is that utility maximization does not describe equiulibrium. I point out that the maximization of Gibbs entropy would describe equilibrium, if equilibrium could be achieved, but equilibrium does not describe real markets. To emphasize the inconsistency of the economists' notion of 'equilibrium', I discuss both deterministic and stochastic dynamics of excess demand and observe that Adam Smith's stabilizing hand is not to be found either in deterministic or stochastic dynamical models of markets, nor in the observed motions of asset prices. Evidence for stability of prices of assets in free markets simply has not been found.

Joseph L. McCauley

1999-11-18

373

STS-103 M.S. Steven Smith during TCDT activities  

NASA Technical Reports Server (NTRS)

STS-103 Mission Specialist Steven L. Smith gets ready to practice driving a small armored personnel carrier that is part of emergency egress training during Terminal Countdown Demonstration Test (TCDT) activities. The tracked vehicle could be used by the crew in the event of an emergency at the pad during which the crew must make a quick exit from the area. The TCDT also provides simulated countdown exercises and opportunities to inspect the mission payloads in the orbiter's payload bay. STS-103 is a 'call-up' mission due to the need to replace and repair portions of the Hubble Space Telescope. Although Hubble is operating normally and conducting its scientific observations, only three of its six gyroscopes are working properly. Four EVA's are planned to make the necessary repairs and replacements on the telescope. The other STS-103 crew members are Commander Curtis L. Brown Jr., Pilot Scott J. Kelly, and Mission Specialists John M. Grunsfeld (Ph.D.), C. Michael Foale (Ph.D.), (Ph.D.), and Claude Nicollier of Switzerland and Jean-Frangois Clervoy of France, who are with the European Space Agency. The mission is targeted for launch Dec. 6 at 2:37 a.m. EST.

1999-01-01

374

Peroxisomal cholesterol biosynthesis and Smith-Lemli-Opitz syndrome  

SciTech Connect

Smith-Lemli-Opitz syndrome (SLOS), caused by 7-dehydrocholesterol-reductase (DHCR7) deficiency, shows variable severity independent of DHCR7 genotype. To test whether peroxisomes are involved in alternative cholesterol synthesis, we used [1-{sup 14}C]C24:0 for peroxisomal {beta}-oxidation to generate [1-{sup 14}C]acetyl-CoA as cholesterol precursor inside peroxisomes. The HMG-CoA reductase inhibitor lovastatin suppressed cholesterol synthesis from [2-{sup 14}C]acetate and [1-{sup 14}C]C8:0 but not from [1-{sup 14}C]C24:0, implicating a peroxisomal, lovastatin-resistant HMG-CoA reductase. In SLOS fibroblasts lacking DHCR7 activity, no cholesterol was formed from [1-{sup 14}C]C24:0-derived [1-{sup 14}C]acetyl-CoA, indicating that the alternative peroxisomal pathway also requires this enzyme. Our results implicate peroxisomes in cholesterol biosynthesis but provide no link to phenotypic variation in SLOS.

Weinhofer, Isabelle [Center for Brain Research, Medical University of Vienna, Vienna (Austria); Kunze, Markus [Center for Brain Research, Medical University of Vienna, Vienna (Austria); Stangl, Herbert [Department of Medical Chemistry, Medical University of Vienna, Vienna (Austria); Porter, Forbes D. [National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD (United States); Berger, Johannes [Center for Brain Research, Medical University of Vienna, Vienna (Austria)]. E-mail: johannes.berger@meduniwien.ac.at

2006-06-23

375

Draft environmental assessment: Deaf Smith County site, Texas. Nuclear Waste Policy Act (Section 112). [Contains Glossary  

SciTech Connect

In February 1983, the US Department of Energy identified a location in Deaf Smith County, Texas, as one of nine potentially acceptable sites for a mined geologic repository for spent nuclear fuel and high-level radioactive waste. The potentially acceptable site was subsequently narrowed to an area of 9 square miles. To determine their suitability, the Deaf Smith site and the eight other potentially acceptable sites have been evaluated in accordance with the DOE's General Guidelines for the Recommendation of Sites for Nuclear Waste Repositories. These evaluations are reported in this draft environmental assessment, which is being issued for public review and comment. The DOE findings and determinations that are based on these evaluations are preliminary and subject to public review and comment. A final EA will be prepared after considering the comments received. On the basis of the evaluations reported in this draft EA, the DOE has found that the Deaf Smith site is not disqualified under the guidelines. The site is in the Permian Basin, which is one of five distinct geohydrologic settings considered for the first repository. This setting contains one other potentially acceptable site - the Swisher site. Although the Swisher site appears to be suitable for site characterization, DOE has concluded that the Deaf Smith site is the preferred site. The DOE finds that the site is suitable for site characterization because the evidence does not support a conclusion that the site will not be able to meet each of the qualifying conditions specified in the guidelines. On the basis of these findings, the DOE is proposing to nominate the Deaf Smith site as one of five sites suitable for characterization. Having compared the Deaf Smith site with the other four sites proposed for nomination, the DOE has determined that the Deaf Smith site is one of the three preferred sites for recommendation to the President as candidates for characterization.

Not Available

1984-12-01

376

PUBLICATIONS --BOOKS Rhodes, O. E., R. K. Chesser, and M. H. Smith (eds). 1996. Population Processes in Ecological Space  

E-print Network

on kidney weight in white-tailed deer. Growth 44:46-53. Smith, M. H. and R. K. Chesser. 1981. Rationale-hemoglobin in white-tailed deer. Journal of Wildlife Management. 46:983-990. Smith, M. W., C. F. Aquadro, M. H. Smith rate in white-tailed deer. Evolution 37:282-291. Nei, M. and R. K. Chesser. 1983. Estimation

Chesser, Ronald Keith

377

A comparison of muscle activation between a Smith machine and free weight bench press.  

PubMed

The bench press exercise exists in multiple forms including the machine and free weight bench press. It is not clear though how each mode differs in its effect on muscle activation. The purpose of this study was to compare muscle activation of the anterior deltoid, medial deltoid, and pectoralis major during a Smith machine and free weight bench press at lower (70% 1 repetition maximum [1RM]) and higher (90% 1RM) intensities. Normalized electromyography amplitude values were used during the concentric phase of the bench press to compare muscle activity between a free weight and Smith machine bench press. Participants were classified as either experienced or inexperienced bench pressers. Two testing sessions were used, each of which entailed either all free weight or all Smith machine testing. In each testing session, each participant's 1RM was established followed by 2 repetitions at 70% of 1RM and 2 repetitions at 90% of 1RM. Results indicated greater activation of the medial deltoid on the free weight bench press than on the Smith machine bench press. Also, there was greater muscle activation at the 90% 1RM load than at the 70% 1RM load. The results of this study suggest that strength coaches should consider choosing the free weight bench press over the Smith machine bench press because of its potential for greater upper-body muscular development. PMID:20093960

Schick, Evan E; Coburn, Jared W; Brown, Lee E; Judelson, Daniel A; Khamoui, Andy V; Tran, Tai T; Uribe, Brandon P

2010-03-01

378

Geology, paleoclimatology and the evolution of the kidney: some explorations into the legacy of Homer Smith.  

PubMed

The aim of this review is to perform an overview of the relation between kidney development in different species and new developments in plate tectonics and paleoclimatology, which likely had a remarkable effect on evolution. The review follows the ideas of Homer Smith, but adds new data on the subjects which were unknown in Homer Smith's time. The structure and function of the kidney are a result of hundreds of millions of years of evolution, in which adaptations had to be made in response to environmental demands while maintaining the kidney's integrated function. The ideas of Homer Smith have greatly contributed to our understanding of this process, and continue to be of relevance both for researchers as well as physicians working in the field of kidney disease. PMID:22572704

Kooman, Jeroen P

2012-01-01

379

"Adam Smith and Social Justice: the Ethical Basis of the Weath of Nations"  

E-print Network

"Adam Smith and Social Justice: the Ethical Basis of the Wealth of Nations'' JACOB OSSÄR The University of Kansas /. Introduction Many in the West seem to regard the collapse of the so-called communist regimes in the Eastern Europe..., No. 2 126 AUSLEGUNG In this paper, I will examine the works of Adam Smith, one of the most influential exponents of modern capitalist economic theory.3 I will argue that his theory does rest and must rest on a number of claims that have far...

Ossar, Jacob

1991-06-01

380

Smith-Doxey Classification, Fiber Testing and Problems of the Cotton Trade.  

E-print Network

or we mailed a questionnaire in June 1955 and were asked the following questions: 1. To what extent are Texas cotton merchants buying cotton on the basis of Smith-Dox classification and what are their chief criticisms of this classing service? 2... shippers, f.0.b. merchants, spot brokers and mill buyers. Of the 65 firms, 53 indicated they purchase some cotton on Smith-Doxey classification and about 38 percent of their total purchases were made on the basis of "green cards" in 1951. Thirty...

Hunt, Robert L.

1956-01-01

381

The Irreducibly Social Self in Classical Economy: Adam Smith and Thomas Chalmers meet G.H. Mead1  

Microsoft Academic Search

The idea of a 'natural harmony' in human affairs runs like a leitmotif through Adam Smith's work. Naturally enough, modern economics has read into this allusion its own preoccupations with the coordination of the strategic decisions of essentially egoistic actors. We will want to argue here, however, that for Smith and his disciple, Thomas Chalmers, successful human interaction is founded

David Wilson; William Dixon

382

Revisiting "No Easy Answers": Application of Sally Smith's Methods in the Lab School of Washington High School Program  

ERIC Educational Resources Information Center

The first edition of "No Easy Answers" (Smith, 1995) was published in 1979, thirty years ago. That seminal work is as relevant today as it was when the book first appeared. This article provides a description of how Sally Smith's Academic Club Method is implemented in the High School program of The Lab School of Washington.

Reynolds, Meredith

2010-01-01

383

Business Ethics and the Origins of Contemporary Capitalism: Economics and Ethics in the Work of Adam Smith and Herbert Spencer  

Microsoft Academic Search

Both Adam Smith and Herbert spencer, albeit in quite different ways, have been enormously influential in what we today take to be philosophies of modern capitalism. Surprisingly it is Spencer, not Smith, who is the individualist, perhaps an egoist, and supports a \\

Patricia H. Werhane

2000-01-01

384

Corrections and Changes for the Paperback Edition of Barton H. Barbour, "Jedediah Smith: No Ordinary Mountain Man."  

E-print Network

asserted that Smith "was the first to travel purposefully the Oregon Trail" westward from the Kansas River River near Grand Island, in present-day Nebraska. Heading up the North Platte, Smith crossed to the Green River, where he wintered. The following spring he collected more of Ashley's trappers and made his

Barrash, Warren

385

Rachel Hogan, Dr John Pye, Dr Clifford Ho, Edward Smith Solar Thermal Group, Research School of Engineering, ANU  

E-print Network

Rachel Hogan¹, Dr John Pye¹, Dr Clifford Ho², Edward Smith² ¹Solar Thermal Group, Research School in software Beheti & Scott, 1980 CSIRO heliostats Gemasolar #12;stg.anu.edu.au 4Hogan, John Pye, Ho and Smith Centroids of focal spot on target Baheti & Scott, 1980 Khalsa, Ho and Andraka, 2011 Sandia beam

386

K. SHAFER SMITH AND ROSS TULLOCH Center for Atmosphere Ocean Science, Courant Institute of Mathematical Sciences, New York University, New York, New York  

E-print Network

Reply K. SHAFER SMITH AND ROSS TULLOCH Center for Atmosphere Ocean Science, Courant Institute). Tulloch and Smith (2006, 2009) argued that sur- face quasigeostrophic effects are consistent with many, Tulloch and Smith (2006) considered a ``toy'' model consisting of SQG flow overlying a finite-depth region

Smith, K. Shafer

387

Hidden species complexes within distinctive taxa: the case of Epanthidium bicoloratum (Smith) (Hymenoptera: Megachilidae)  

Technology Transfer Automated Retrieval System (TEKTRAN)

Epanthidium bicoloratum (Smith) differs from all other Neotropical Anthidiini in the distinctive tegula, which is narrowed posteriorly forming a slender wedge. Examination of material standing under this name revealed that it represents a species complex that includes three new cryptic species, E. ...

388

The Perceived Significance of Suicide in Male vs. Female Breadwinners Steven M. Smith 1  

E-print Network

The Perceived Significance of Suicide in Male vs. Female Breadwinners Steven M. Smith 1 1 significance of male and female suicide as viewed by a third party member/member of the public. Specifically it investigates if differences exist in perceived significance of a male or female suicide when the suicide

Zhou, Yaoqi

389

Brendan Powell Smith pulls back his curly shoulder-length hair and scans  

E-print Network

of the book tells the story of the American Revolution; half is dedicated to the French Revolution. Smith (CAS of the American Revolution and the Inspiring Fight for Liberty and Equality That Shook the World, to be published to form the base of the guillotine, which he'll use to illustrate the execution of Louis XVI. The French

Spence, Harlan Ernest

390

Back to the Future on Gender and Anti-School Boys: A Response to Jeffrey Smith  

ERIC Educational Resources Information Center

This article examines recent claims by Jeffrey Smith that: (1) "hegemonic masculinity" is an expression of working class counter-school culture; (2) some teachers are "cultural accomplices" in constructing "hegemonic masculinities" of anti-school working class boys, thereby contributing to their underachievement; and (3) these "cultural…

Abraham, John

2008-01-01

391

Ideology and Reform in Teacher Education in England: Some Reflections on Cochran-Smith and Fries.  

ERIC Educational Resources Information Center

Presents an international perspective on Cochran-Smith and Fries' recent analysis of the ways that two competing ideologies (deregulation and professionalization) are being employed in the United States to support teacher education reform, noting important differences between the United States and England in how these ideologies have been advanced…

Furlong, John

2002-01-01

392

Interfaces in Driven Ising Models: Shear Enhances Confinement Thomas H. R. Smith,1  

E-print Network

Interfaces in Driven Ising Models: Shear Enhances Confinement Thomas H. R. Smith,1 Oleg Vasilyev,2 Douglas B. Abraham,2,3 Anna Maciolek,2,3,4 and Matthias Schmidt1 1 H.H. Wills Physics Laboratory, University of Bristol, Tyndall Avenue, Bristol BS8 1TL, United Kingdom 2 Max-Planck-Institut fu¨r

Schmidt, Matthias

393

Gamma Rays from Lightning David M. Smith, Brian Grefenstette, Jacob Stanley,  

E-print Network

Gamma Rays from Lightning David M. Smith, Brian Grefenstette, Jacob Stanley, SCIPP, U. C. Santa associated with thunderstorms & individual lightning flashes: Red sprites, sprite halos, blue jets: Elves (propagation of lightning to the ground) Any free electron gains enough energy between collisions to ionize

California at Santa Cruz, University of

394

Journal of Theoretical Biology 239 (2006) 172182 The Maynard Smith model of sympatric speciation  

E-print Network

Journal of Theoretical Biology 239 (2006) 172­182 The Maynard Smith model of sympatric speciation October 2005 Abstract The paper entitled ``Sympatric speciation,'' which was published by John Maynard for sympatric speciation. A part of that paper was devoted to a specific two-locus, two-allele model

Gavrilets, Sergey

395

Tribal Tourism in Fiji: An Application and Extension of Smith's 4Hs of Indigenous Tourism  

Microsoft Academic Search

Indigenous tourism has seen significant growth in recent years. This type of cultural tourism is often seen as a way to promote and reinforce native culture and provide pro-poor benefits to the local community. This research extends the predominantly supply-side view of indigenous tourism put forward by Smith [1996. Indigenous tourism: The four Hs. In R. Butler & T. Hinch

Stephen Pratt; Dawn Gibson; Apisalome Movono

2012-01-01

396

Optical spectroscopy of tungsten carbide ,,WC... Shane M. Sickafoose, Adam W. Smith, and Michael D. Morse  

E-print Network

Optical spectroscopy of tungsten carbide ,,WC... Shane M. Sickafoose, Adam W. Smith, and Michael D transition-metal carbide, WC. A low-resolution scan revealed a five-member vibrational progression beginning to the isovalent molecule MoC and other transition-metal carbides. © 2002 American Institute of Physics. DOI: 10

Morse, Michael D.

397

OBLIQUE VIEW FROM THE SOUTH Camp H.M. Smith and ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

OBLIQUE VIEW FROM THE SOUTH - Camp H.M. Smith and Navy Public Works Center Manana Title VII (Capehart) Housing, Three-Bedroom Single-Family Type 7, Birch Circle, Elm Drive, Elm Circle, and Date Drive, Pearl City, Honolulu County, HI

398

OBLIQUE VIEW FROM THE SOUTH CORNER Camp H.M. Smith ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

OBLIQUE VIEW FROM THE SOUTH CORNER - Camp H.M. Smith and Navy Public Works Center Manana Title VII (Capehart) Housing, U-Shaped Two-Bedroom Single-Family Type 6, Birch Circle, Elm Drive, Elm Circle, and Date Drive, Pearl City, Honolulu County, HI

399

BEDROOM 3. VIEW FACING EAST Camp H.M. Smith and ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

BEDROOM 3. VIEW FACING EAST - Camp H.M. Smith and Navy Public Works Center Manana Title VII (Capehart) Housing, Three-Bedroom Single-Family Type 7, Birch Circle, Elm Drive, Elm Circle, and Date Drive, Pearl City, Honolulu County, HI

400

BEDROOM 2. VIEW FACING EAST Camp H.M. Smith and ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

BEDROOM 2. VIEW FACING EAST - Camp H.M. Smith and Navy Public Works Center Manana Title VII (Capehart) Housing, U-Shaped Two-Bedroom Single-Family Type 6, Birch Circle, Elm Drive, Elm Circle, and Date Drive, Pearl City, Honolulu County, HI

401

UTILITY ROOM. VIEW FACING WEST Camp H.M. Smith and ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

UTILITY ROOM. VIEW FACING WEST - Camp H.M. Smith and Navy Public Works Center Manana Title VII (Capehart) Housing, Three-Bedroom Single-Family Type 7, Birch Circle, Elm Drive, Elm Circle, and Date Drive, Pearl City, Honolulu County, HI

402

BEDROOM 2. VIEW FACING EAST Camp H.M. Smith and ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

BEDROOM 2. VIEW FACING EAST - Camp H.M. Smith and Navy Public Works Center Manana Title VII (Capehart) Housing, Three-Bedroom Single-Family Type 7, Birch Circle, Elm Drive, Elm Circle, and Date Drive, Pearl City, Honolulu County, HI

403

BATH. VIEW FACING NORTH Camp H.M. Smith and Navy ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

BATH. VIEW FACING NORTH - Camp H.M. Smith and Navy Public Works Center Manana Title VII (Capehart) Housing, U-Shaped Two-Bedroom Single-Family Type 6, Birch Circle, Elm Drive, Elm Circle, and Date Drive, Pearl City, Honolulu County, HI

404

Folding the circle in half is a text book of information. Bradford Hansen-Smith  

E-print Network

231 Folding the circle in half is a text book of information. Bradford Hansen-Smith Wholemovement, Chicago IL, USA brad@wholemovement.com Abstract This paper addresses folding the circle in half. The simplicity of process in understanding fundamentals of mathematics by folding circles and observing what

Spagnolo, Filippo

405

Problem Behaviors Associated with Deletion Prader-Willi, Smith-Magenis, and Cri Du Chat Syndromes.  

ERIC Educational Resources Information Center

Problem behaviors of 38 individuals with Cri-du-Chat syndrome, 55 individuals with Prader Willi syndrome, and 21 individuals with Smith-Magenis syndrome were investigated. All three disorders were Associated with greater ratings of problem behaviors (besides eating abnormalities and sleep abnormalities) than comparison groups. (Author/CR)

Clarke, David J.; Boer, Harm

1998-01-01

406

Analyzing the Expressive Range of a Level Generator Gillian Smith Jim Whitehead  

E-print Network

Analyzing the Expressive Range of a Level Generator Gillian Smith Jim Whitehead Expressive}@soe.ucsc.edu ABSTRACT This paper explores a method for analyzing the expressive range of a procedural level generator, and applies this method to Launchpad, a level generator for 2D platformers. Instead of focusing on the number

Whitehead, James

407

Alteration of 'Granny Smith' Apple Peel Metabolic Profiles by Postharvest UV/Visable Irradiation  

Technology Transfer Automated Retrieval System (TEKTRAN)

Light exposure stimulates an array of responses in apple peel including photosynthesis and pigment metabolism. While the specifics of many metabolic processes stimulated by light are known, impacts of light on primary metabolism in apple peel are relatively uncharacterized. ‘Granny Smith’ apples, ...

408

Modified Smith predictor scheme for periodic disturbances reduction in the continuous casting process  

Microsoft Academic Search

In the continuous casting process, various control strategies are used to reduce the mold level fluctuations which cause surface defects in the final product. This paper proposes a control structure able to improve the reduction of the bulging effect on the mold level. It is based on the Astroumlm's modified Smith predictor scheme which presents the advantage that the setpoint

K. Jabri; D. Dumur; E. Godoy; A. Mouchette; B. Bele

2009-01-01

409

L-system description of subdivision curves Przemyslaw Prusinkiewicz, Faramarz Samavati, Colin Smith, and Radoslaw Karwowski  

E-print Network

Chaikin, cubic B-spline, and Dyn-Levin-Gregory (4-point) subdivision schemes as examples. L Chaikin, cubic B-spline, and Dyn-Levin-Gregory (4-point) subdivision schemes as examples. L directly leads to their computer implementation. Reference P. Prusinkiewicz, F. Samavati, C. Smith, R

Prusinkiewicz, Przemyslaw

410

An Architecture for Cross-Cloud System Management R. Dodda, C. Smith, A. van Moorsel.  

E-print Network

and adaptability promised by the cloud computing paradigm, whilst enabling the benefits of cross-cloud resource the flexibility and adaptability promised by the cloud computing paradigm, whilst enabling the benefits of cross-cloudCOMPUTING SCIENCE An Architecture for Cross-Cloud System Management R. Dodda, C. Smith, A. van

Newcastle upon Tyne, University of

411

The logic of economic discourse: beyond Adam Smith and Karl Marx  

Microsoft Academic Search

Economic discourse has two interesting properties. It tends to be all-encompassing and it tends to shape the reality which it sets out to describe. Systems of economic theory can become very powerful and those based on ideas from Adam Smith and Karl Marx are good examples. Each of these has produced serious problems which are difficult to cope with because

Leslie Armour

1997-01-01

412

Beyond Adam Smith and Karl Marx: visions and versions of future society  

Microsoft Academic Search

Marx and Smith share the accusation of musing about future society, but of being much too vague about the form. At the same time, there is no glaring dearth of those who hailed the collapse of the Soviet economy as proof positive of the failure of Marxism, of Marx’s system. This boils down to the question of whether or not

Thomas O. Nitsch

1999-01-01

413

Improved Routing Wasps for Distributed Factory Control Vincent A. Cicirello and Stephen F. Smith  

E-print Network

Improved Routing Wasps for Distributed Factory Control Vincent A. Cicirello and Stephen F. Smith approach to coordinating factory routing and scheduling based on a computational model of wasp behavior. The natural multi-agent sys- tem of the wasp colony is highly effective in self- organizing the allocation

Cicirello, Vincent A.

414

VIRUS DYNAMICS: A GLOBAL ANALYSIS PATRICK DE LEENHEER AND HAL L. SMITH  

E-print Network

VIRUS DYNAMICS: A GLOBAL ANALYSIS PATRICK DE LEENHEER AND HAL L. SMITH SIAM J. APPL. MATH. c 2003 and Nelson [SIAM Rev., 41 (1999), pp. 3­44] and Nowak and May [Virus Dynamics, Oxford University Press, New of their dynamics. If the basic reproduction number R0 virus is cleared and the disease dies out; if R0 > 1

De Leenheer, Patrick

415

Barriers and Promises in STEM Reform Melissa H. Dancy, Johnson C. Smith University  

E-print Network

Barriers and Promises in STEM Reform Melissa H. Dancy, Johnson C. Smith University Charles Henderson, Western Michigan University Introduction There have been many calls for the reform that these reform efforts are having only a marginal impact. For example, as the rationale for its 2003 report

Henderson, Charles

416

Latent Theoretical Convergence upon a Pluralist Conception of Economic Action: Adam Smith and Max Weber  

Microsoft Academic Search

This paper engages in exploring certain latent theoretical convergences between the works of Adam Smith and Max Weber. The fact that these two have been major protagonists in the establishment and development of political economy and sociology respectively gives a rationale to such an endeavor. Another rationale is provided by the paucity of attempts at exploring the theoretical relations between

Milan Z. Zafirovski

2000-01-01

417

Back to Beginnings: Credentialism, Productivity, and Adam Smith's Division of Labour.  

ERIC Educational Resources Information Center

The foundation of factional pressures for upgrading educational credentials in the labor market is examined through a review of human capital and screening theories. The writings of Adam Smith are referenced to show that the claims of the beneficial effects of educational upgrading have been questioned for 200 years. (Author/MLW)

Davis, Denis J.

1981-01-01

418

Adam Smith, Adam Ferguson and Karl Marx on the Division of Labour  

Microsoft Academic Search

Adam Smith (1723—90) and Adam Ferguson (1723—1816) shared a keen interest in the social, economic and individual effects of specialization. Though this mutual interest led to a protracted priority dispute between them, nevertheless their approaches differed significantly. Ferguson was generally more negative in his attitude and was also less interested in the economic effects of specialization, focusing instead on its

Lisa Hill

2007-01-01

419

Comparing Adam Smith's Wealth of Nations to James Madison's Federalist #10.  

ERIC Educational Resources Information Center

Presents a lesson which calls upon students to compare Adam Smith's WEALTH OF NATIONS to James Madison's FEDERALIST #10 to see how the ancient concept of individual rights and liberties was used to describe both economic and governmental systems. Presents questions to provide the basis for comparison. (GEA)

Mundell, Jean

1987-01-01

420

Free-electron maser based on the Smith-Purcell effect  

NASA Astrophysics Data System (ADS)

This paper reports the experimental results of the Smith-Purcell free-electron maser (orotron) developed at University of Electronic Science and Technology of China (UESTC). The output powers from this FEM are 200 and 1200 mw, respectively, at 3 and 4 mm wavelengths.

Chen, Jiayu; Zhang, Yongchuan; Duan, Yuxiang; Yang, Ziqiang; Li, Dazhi; Liang, Zheng

1998-02-01

421

A Test of Amino Acid Reversibility Nick G.C. Smith, Adam Eyre-Walker  

E-print Network

A Test of Amino Acid Reversibility Nick G.C. Smith, Adam Eyre-Walker Centre for the Study no evidence to reject the assumption of reversibility in protein evolution. Key words: Amino acid evolution the evolution of proteins, it is generally assumed that the number of substitutions from amino acid X to amino

Eyre-Walker, Adam

422

Celebrating the Past, Ensuring the Future--A Profile of President Glenn Smith  

ERIC Educational Resources Information Center

"I had no idea how to convince someone to hire me," recalls APPA President, Glen Smith. His first interview was with Bryn Mawr College, a small, prestigious private college with Quaker roots, located 12 miles west of Philadelphia. That was in 1997, after 24 years in the Naval Civil Engineer Corps, and he still remembers a certain…

Blumenthal, Anita

2013-01-01

423

ESTIMATION OF SURPLUS BIOMASS OF CLUPEIDS IN SMITH MOUNTAIN LAKE, VIRGINIA  

EPA Science Inventory

Mean annual estimates of surplus biomass of alewife Alosa pseudoharengus and gizzard shad Dorosoma cepedianum in Smith Mountain Lake, Virginia, were calculated using data on the biomass, growth, and mortality of each clupeid species. Surplus biomass, defined as production over a...

424

Sally L. Smith: A Genius at Seeing the Potential in People  

ERIC Educational Resources Information Center

What this author admired most about Sally Smith was the fact that she was a visionary about people and what they could accomplish. She saw more potential in a person--young or old--than anybody or even they themselves, frankly, had ever even considered possible. She was a genius at seeing the potential in people, expecting them to find it in…

Edgerton, Mary Allen

2010-01-01

425

LIFE HISTORY MONITORING OF SALMONIDS IN THE WEST FORK SMITH RIVER, UMPQUA BASIN, OREGON  

EPA Science Inventory

As a life-cycle monitoring basin for the Oregon Salmon Plan, the Oregon Department of Fish and Wildlife has estimated adult returns, distribution and smolt outmigration of coho, chinook and winter steelhead in the West Fork Smith River since 1998. In 2001/2002, the Environmenta...

426

Sally Smith's Arts-Based and Integrated Curricular Approach to Educating Students with Learning Disabilities  

ERIC Educational Resources Information Center

Founded in 1967, The Lab School of Washington (LSW) has been educating students with learning disabilities using an arts-based curriculum for over 50 years. Sally Smith originally started the school out of frustration with the inability of traditional educational environments to reach her intelligent, but learning disabled, young son and others…

Durham, Jennifer

2010-01-01

427

EFFECTS OF SOME TRACE ELEMENTS ON THE BLOOD OF KUWAIT MULLETS 'LIZA MACROLEPS' (SMITH)  

EPA Science Inventory

Haemopathological changes attributed to heavy metal poisoning observed in blood smears of Liza macrolepis (Smith) taken after exposures of 96 h to graded doses (mg/l) of copper (0.11-1.80), lead (1.15-18.36), and mercury (0.04-0.59), in a flow-through marine bioassay system. In g...

428

Another Look at the Glass and Smith Study on Class Size  

ERIC Educational Resources Information Center

One of the most influential studies affecting educational policy is Glass and Smith's 1978 study, "Meta-Analysis of Research on the Relationship of Class-Size and Achievement." Since its publication, educational policymakers have referenced it frequently as the justification for reducing class size. While teachers and the public had long believed…

Phelps, James L.

2011-01-01

429

On The Ten Point Wood-Desargues' Configuration Christopher J Bradley and Geoff C Smith  

E-print Network

1 Article 6 On The Ten Point Wood-Desargues' Configuration Christopher J Bradley and Geoff C Smith Abstract The ten pairs of directly similar triangles in perspective in the Wood-Desargues' configuration are similar to the five cyclic quadrangles of the initial Wood-Desargues' configuration and that these five

Smith, Geoff

430

A Multithreaded Java Grande Benchmark Suite L. A. Smith and J. M. Bull  

E-print Network

parallel benchmarks has been developed from the serial Java Grande benchmark suite, using Java nativeA Multithreaded Java Grande Benchmark Suite L. A. Smith and J. M. Bull EPCC, The King's Buildings execution environments that can be tested using the Java Grande benchmark suite [5], [6], [7]. The large

Bull, Mark

431

Manufacturing Feature Identification for Intelligent Design Alice E. Smith, Ph.D., P.E.  

E-print Network

Manufacturing Feature Identification for Intelligent Design Alice E. Smith, Ph.D., P.E. Department.g. knowledge based systems or human designers) to manipulate and combine. The objective in using intelligent of Engineering Management University of Missouri - Rolla Rolla, MO 65401 A Chapter in Intelligent Systems

Smith, Alice E.

432

The Construction of Social Reality: An Exchange Barry Smith and John Searle  

E-print Network

Journal of Economics and Sociology I. Barry Smith: The Ontology of Social Reality A Two-Levelled Ontology In The Construction of Social Reality, John Searle argues for a two-level ontology along the following lines. Facts. This question is not at issue here. Searle tells us what social objects are by giving us an account of the way

López-Sánchez, Maite

433

Report of Progress at the Troupe Sub-Station, Smith County Texas.  

E-print Network

TEXAS AGRICULTUR 146-409-lorn [PERIMENT STATIONS BULLETIN NO. 121 FEBRUARY 1, 1909 REPORT OF PROGRESS AT THE TROUPE SUB-STATION, SMITH COUNTY, TEXAS W. H. HOTCHKISS, SUPERINTENDENT IN CHARGE POSTOFFICE COLLEGE STATION, BRAZOS COUNTY..., TEXAS TEXAS AGRICULTURAL EXPERIMENT STATIONS. 'FICERS. tiu v hnNING BOARD. ............................... H. I<. LEGETT, President. .Abilene. .......................... T. D. ROWELL, Vice-President. .Jefferson...

Hotchkiss, W.S.

1909-01-01

434

A Sound Polymorphic Type System for a Dialect of C Geoffrey Smith  

E-print Network

A Sound Polymorphic Type System for a Dialect of C Geoffrey Smith School of Computer Science into a dialect of C, which we call Polymorphic C. It has the same pointer operations as C, including the address of Computer Programming, vol. 32, nos. 2­3, 1998. This material is based upon work supported by the National

Smith, Geoffrey

435

Testing Four- and Five-Year-Olds: Response to Salzer and to Shepard and Smith.  

ERIC Educational Resources Information Center

Supports articles in this "Educational Leadership" issue by Robert Salzer and by Lorrie A. Shepard and Mary Lee Smith concerning overtesting for developmental maturity and school readiness. Underlines differences between screening and readiness tests and sets out criteria for selection and usage--to determine appropriate services for young…

Meisels, Samuel J.

1986-01-01

436

Early Screening Is Essential for Educational Accountability: Response to Salzer and to Shepard and Smith.  

ERIC Educational Resources Information Center

Responds to two articles in this "Educational Leadership" issue by Richard Salzer and by Lorrie A. Shepard and Mary Lee Smith that criticize overtesting and preoccupation with developmental differences in kindergarten-age children. Defends physical, sensory, and developmental assessment to help identify children's areas of strength and weakness.…

Judy, Judy

1986-01-01

437

Properties of 2,2,2-trifluoroethanol and water mixtures Rajappa Chitra and Paul E. Smith  

E-print Network

Properties of 2,2,2-trifluoroethanol and water mixtures Rajappa Chitra and Paul E. Smith Department atomic level understanding of the properties of TFE/water mixtures. The trends in most properties of pure TFE are presented in Table I,7­26 together with the corresponding properties of water and ethanol

Smith, Paul E.

438

MASTER BATH. VIEW FACING EAST Camp H.M. Smith and ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

MASTER BATH. VIEW FACING EAST - Camp H.M. Smith and Navy Public Works Center Manana Title VII (Capehart) Housing, U-Shaped Three-Bedroom Duplex Type 2, Acacia Road, Birch Circle, and Cedar Drive, Pearl City, Honolulu County, HI

439

Map of Douglass parking deck and Mabel Smith Douglass Library, Douglass Campus, Rutgers  

E-print Network

RT 18 Nichol Avenue Ryders Lane Commercial Avenue Map of Douglass parking deck and Mabel Smith turns into Nichol Ave as it intersects George Street) Douglass Library: http the "Commercial Avenue" exit to the left. At the light, make a left onto Commercial Avenue. At the second light

Delgado, Mauricio

440

Reusable Features for VoIP Service Realization Thomas M. Smith  

E-print Network

.00. standards such as the IP Multimedia Subsystem (IMS) [19] and the SIP Servlet 1.1 specification [11Reusable Features for VoIP Service Realization Thomas M. Smith AT&T Labs Research 180 Park Avenue Telecommunications, VoIP, features, application composi- tion, design patterns, software reuse 1. INTRODUCTION A wide

Fisher, Kathleen

441

Mercury concentration in fish from Smith Mountain Lake. [Monroe saxatilis; Mirropterus salmoides; Ictalurus punctatus  

Microsoft Academic Search

Mercury levels were determined in fish taken from Smith Mountain Lake, a 20,000 acre pump-storage reservoir in southwestern Virginia. Striped bass (Monroe saxatilis), largemouth bass (Mirropterus salmoides), and channel catfish (Ictalurus punctatus) were collected during 1987 and 1988 by personnel from Ferrum College and the Virginia Commission of Game and Inland Fisheries. A total of 51 fish were analyzed for

A. P. Corkum; D. M. Johnson

2009-01-01

442

GIS TOPICS 6395 Instructor: Scot E. Smith, Professor, Geomatics Program, School of Forest Resources and  

E-print Network

GIS TOPICS 6395 Instructor: Scot E. Smith, Professor, Geomatics Program, School of Forest Resources: Reading Assignments GOALS AND OBJECTIVES: This course presents practical applications of GIS as it is used of modern GIS software an appreciation of the ways in which GIS technology can be used in areas

Watson, Craig A.

443

Prevalence, Phenomenology, Aetiology and Predictors of Challenging Behaviour in Smith-Magenis Syndrome  

ERIC Educational Resources Information Center

Background: The prevalence, phenomenology aetiology and correlates of four forms of challenging behaviour in 32 children and adults with Smith-Magenis syndrome (SMS) were investigated. Methods: Cognitive assessments, questionnaires and semi-structured interviews were used to gather data on intellectual disability, verbal and physical aggression,…

Sloneem, J.; Oliver, C.; Udwin, O.; Woodcock, K. A.

2011-01-01

444

Discovery and antitumor activities of constituents from Cyrtomium fortumei (J.) Smith rhizomes  

PubMed Central

Background Cyrtomium fortumei (J.) Smith is an important Chinese herbal medicine because of its biological functions. However, systematic and comprehensive studies on the phytochemicals from Cyrtomium fortumei (J.) Smith and their bioactivity are limited. Results Using the bioassay-guided technique, the ethyl acetate and n-BuOH extracts of the rhizomes of Cyrtomium fortumei (J.) Smith were shown to exhibit good antitumor activities, consequently leading to the isolation of 23 compounds. All compounds were isolated from the plant for the first time. The inhibitory activities of these compounds were investigated on tumor cells MGC-803, PC3, and A375 in vitro by MTT (thiazolyl blue tetrazolium bromide) assay, and the results showed that pimpinellin (3) had potent cytotoxic activities against the three cell lines, with the IC50 values of 14.4?±?0.3??M, 20.4?±?0.5??M, and 29.2?±?0.6??M, respectively. The mechanism of the antitumor action indicated that pimpinellin inhibited the growth of MGC-803 cells via the induction of tumor cell apoptosis, with apoptosis ratio of 27.44% after 72?h of treatment at 20??M. Conclusions This study suggests that most of the compounds from the roots of Cyrtomium fortumei (J.) Smith could inhibit the growth of human carcinoma cells. Moreover, pimpinellin inhibited the growth of tumor cells via the induction of tumor cell apoptosis. PMID:23379693

2013-01-01

445

Synthesis of a Parallel Smith-Waterman Sequence Alignment Kernel into FPGA Hardware  

E-print Network

the issue of making FPGA- based co-processors accessible to systems biologists who do not have an extensive to exploit FPGA-based co-processors to compute operations like DNA sequence matching without a requirementSynthesis of a Parallel Smith-Waterman Sequence Alignment Kernel into FPGA Hardware David Greaves

Greaves, David J.

446

Bounded Linear Types in a Resource Semiring Dan R. Ghica and Alex Smith  

E-print Network

Bounded Linear Types in a Resource Semiring Dan R. Ghica and Alex Smith University of Birmingham on a general notion of resource which can be modeled in a semiring. For this type system we provide both a general type-inference procedure, parameter- ized by the decision procedure of the semiring equational

Ghica, Dan

447

corresponding author, aguswa@email.smith.edu Meteorology of Monteverde, Costa Rica  

E-print Network

corresponding author, aguswa@email.smith.edu Meteorology of Monteverde, Costa Rica 2007 Technical at the Monteverde Institute (MVI) in Monteverde, Costa Rica records precipitation, temperature, relative humidity 1 Introduction 1.1 Climate Monteverde, Costa Rica (84°48' W Long., 10°18' N Lat., see Figure 1) lies

Guswa, Andrew J.

448

corresponding author, aguswa@email.smith.edu Meteorology of Monteverde, Costa Rica  

E-print Network

corresponding author, aguswa@email.smith.edu Meteorology of Monteverde, Costa Rica 2006 Technical at the Monteverde Institute (MVI) in Monteverde, Costa Rica records precipitation, temperature, relative humidity Report 3 Guswa and Rhodes, 2007 1 Introduction 1.1 Climate Monteverde, Costa Rica (84°48' W Long., 10

Guswa, Andrew J.

449

corresponding author, aguswa@email.smith.edu Meteorology of Monteverde, Costa Rica  

E-print Network

corresponding author, aguswa@email.smith.edu Meteorology of Monteverde, Costa Rica 2005 Technical at the Monteverde Institute (MVI) in Monteverde, Costa Rica measures precipitation, temperature, wind speed and Rhodes, 2006 1 Introduction 1.1 Climate Monteverde, Costa Rica (84°48' W Long., 10°18' N Lat., see Figure

Guswa, Andrew J.

450

Development and Behaviour in Marshall-Smith Syndrome: An Exploratory Study of Cognition, Phenotype and Autism  

ERIC Educational Resources Information Center

Background: Marshall-Smith syndrome (MSS) is an infrequently described entity characterised by failure to thrive, developmental delay, abnormal bone maturation and a characteristic face. In studying the physical features of a group of patients, we noticed unusual behavioural traits. This urged us to study cognition, behavioural phenotype and…

van Balkom, I. D. C.; Shaw, A.; Vuijk, P. J.; Franssens, M.; Hoek, H. W.; Hennekam, R. C. M.

2011-01-01

451

INFRARED LIGHT CURVES OF MIRA VARIABLE STARS FROM COBE DIRBE DATA Beverly J. Smith  

E-print Network

INFRARED LIGHT CURVES OF MIRA VARIABLE STARS FROM COBE DIRBE DATA Beverly J. Smith Department of Physics and Astronomy, East Tennessee State University, Box 70652, Johnson City, TN 37614; smithbj@pari.edu and Donald Luttermoser Department of Physics and Astronomy, East Tennessee State University, Box 70652

Luttermoser, Donald G.

452

Teaching Excellence: A Reaction to the Smith Commission Report and Its Effects.  

ERIC Educational Resources Information Center

A response is presented to the "Report of the Commission of Inquiry on Canadian University Education" (Smith Commission Report) and to the reactions it has elicited. Proposed methods of reform are seen as similar to those already implemented, and suggests that changes in the university infrastructure to support good teaching and research equally…

Samad, D. R.; And Others

1995-01-01

453

Discovery of nitrogen in Saturn's inner magnetosphere H. T. Smith,1  

E-print Network

Discovery of nitrogen in Saturn's inner magnetosphere H. T. Smith,1 M. Shappirio,2 E. C. Sittler,2 detected N+ in Saturn's magnetosphere in the range L $ 3.5 to $9.5 Saturn Radii (Rs) using data collected by the Cassini Plasma Spectrometer during Saturn Orbit Insertion and the following orbit (Rev A). The presence

Johnson, Robert E.

454

Kandler Smith, NREL EDV Battery Robust Design -1 Design of Electric Drive Vehicle  

E-print Network

#12;Kandler Smith, NREL EDV Battery Robust Design - 4 Li+ V Typical Structure of Li-ion Batteries V EDV Battery Robust Design - 5 Performance Life Cost Safety Requirements Multi-Scale Physics in Li-ion Outline Aging mechanisms in Li-ion batteries Aging models based on accelerated testing Robust design

455

A Domain Wall Model for Ferroelectric Hysteresis Ralph C. Smith 1 and Craig L. Hom 2  

E-print Network

from a PMN­PT­BT actuator operating at a temperature within the ferroelectric regime. Keywords: Domain of these materials in high performance actuator design. The nature of hysteresis models for ferroelectric materialsA Domain Wall Model for Ferroelectric Hysteresis Ralph C. Smith 1 and Craig L. Hom 2 1 Center

456

A Domain Wall Model for Ferroelectric Hysteresis Ralph C. Smith1 and Craig L. Hom2  

E-print Network

from a PMN-PT-BT actuator operating at a temperature within the ferroelectric regime. Keywords: Domain of these materials in high performance actuator design. The nature of hysteresis models for ferroelectric materialsA Domain Wall Model for Ferroelectric Hysteresis Ralph C. Smith1 and Craig L. Hom2 1Center

457

Mountain Precipitation and Hydrology in the Middle East Ronald. B. Smith*, Jason Evans*, Robert Oglesby**  

E-print Network

Mountain Precipitation and Hydrology in the Middle East Ronald. B. Smith*, Jason Evans*, Robert Arabia and Central Asia. In both Europe and southwest Asia, elevated terrains have higher precipitation responsible for the surrounding dry climates. An important aspect of orographic precipitation is the rain

Evans, Jason

458

Cryptographic Support in a Gigabit Network Jonathan M. Smith (jms@aurora.cis.upenn.edu)  

E-print Network

Cryptographic Support in a Gigabit Network Jonathan M. Smith (jms@aurora.cis.upenn.edu) C. Brendan S. Traw (traw@aurora.cis.upenn.edu) David J. Farber (farber@cis.upenn.edu) Distributed Systems boards were built to understand architectural issues in providing crypto- graphic support for the AURORA

Smith, Jonathan M.

459

Analysis of the Sensory Profile in Children with Smith-Magenis Syndrome  

ERIC Educational Resources Information Center

This study systematically assessed sensory processing in 34 children, aged 3-14 years, with Smith-Magenis syndrome (SMS) using the Sensory Profile Caregiver Questionnaire. Scores for the SMS cohort were significantly different from scores of the national sample of children with and without disabilities in all Sensory Profile categories and…

Hildenbrand, Hanna L.; Smith, Ann C. M.

2012-01-01

460

Habitat Use by Juvenile Salmonids in the Smith River Estuary, California  

Microsoft Academic Search

Estuaries are highly productive areas that serve as important nursery habitat for many species of fish. Estuaries provide juvenile salmonids Oncorhynchus spp. with foraging habitats, refuge from predators, and areas in which smoltification and orientation for return migrations can occur. Our primary goal was to describe how juvenile salmonids use the Smith River estuary in northern California, a system that

Rebecca M. Quiñones; Timothy J. Mulligan

2005-01-01

461

A Case Study of Early Development in Smith-Magenis Syndrome  

ERIC Educational Resources Information Center

The aim of this article is to provide an in-depth description of early development in a young child with Smith-Magenis syndrome (SMS). SMS is a multisystem, neurodevelopmental genetic disorder associated with mental retardation that predisposes individuals to a distinct pattern of maladaptive behaviors and other neuropsychological impairments.…

Fidler, Deborah J.; Philofsky, Amy D.; Hepburn, Susan L.

2006-01-01

462

A Parallel Java Grande Benchmark Suite L. A. Smith and J. M. Bull  

E-print Network

A Parallel Java Grande Benchmark Suite L. A. Smith and J. M. Bull EPCC, The King's Buildings Republic. email: xobdrzal@fi.muni.cz Abstract Increasing interest is being shown in the use of Java for large scale or Grande applications. This new use of Java places specific demands on the Java execution

Bull, Mark

463

"Comments on Coulter and Smith": Narrative Researchers as Witnesses of Injustice and Agents of Social Change?  

ERIC Educational Resources Information Center

In commenting on Coulter and Smith (2009), the author explores issues related to the place of the political in education research and in literature, but especially in forms of narrative research that possess both scientific and literary dimensions. More specifically, the author examines four sets of issues related to the researching and writing of…

Barone, Tom

2009-01-01

464

Biomarkers of Leukemia Risk: Benzene Martyn T. Smith and Luoping Zhang  

E-print Network

Biomarkers of Leukemia Risk: Benzene as a Model Martyn T. Smith and Luoping Zhang Division relatively rare, leukemias place a considerable financial burden on society and cause psychologic trauma to many families. Leukemia is the most common cancer in children. The causes of leukemia in adults

California at Berkeley, University of

465

A Macrobotanical Analysis of Native American Maize Agriculture at the Smith's Point Site  

Microsoft Academic Search

The Smith's Point site was a seasonally inhabited Native American encampment in Yarmouth, Massachusetts occupied from the Middle Woodland through the early Colonial periods. Excavations at the site in the early 1990s yielded the remains of a multi-component site including both an agricultural field and an adjacent living area. The macrobotanical remains from the agricultural and living area features were

Kelly A. Ferguson

2010-01-01

466

The sodium tail of the Moon M. Matta a,b,*, S. Smith a,1  

E-print Network

The sodium tail of the Moon M. Matta a,b,*, S. Smith a,1 , J. Baumgardner a,1 , J. Wilson a,1 , C 2009 Available online xxxx Keywords: Moon Meteors Solar wind Solar radiation Image processing a b s t r a c t During the few days centered about new Moon, the lunar surface is optically hidden from Earth

Mendillo, Michael

467

How Smith Cleared the Way for More Transfer Students from a Community College.  

ERIC Educational Resources Information Center

Smith College (Massachusetts) has established formal articulation agreements with Santa Monica College (California) and Miami-Dade Community College (Florida) to grant credit to community college students transferring to the private college. Vassar College (New York) is another private liberal arts college seeking more community college transfer…

Geraghty, Mary

1997-01-01

468

Coqa: Concurrent Objects with Quantized Yu David Liu Xiaoqi Lu Scott F. Smith  

E-print Network

, greatly reducing the number of interleavings to con- sider. Rather than building atomicity locally, iCoqa: Concurrent Objects with Quantized Atomicity Yu David Liu Xiaoqi Lu Scott F. Smith Department program writ- ten in our language has the desirable behaviors of atomicity, mutual exclusion, and race

Smith, Scott F.

469

Travel Time Models MacGregor Smith & Cruz State Dependent Travel Time Models, Properties,  

E-print Network

Travel Time Models MacGregor Smith & Cruz State Dependent Travel Time Models, Properties, & Kerner networks is an accurate estimate of travel time on arterial links, highway, and freeways way to esti- mate travel times for this complex task. Realistically, however, travel time is a random

Cruz, Frederico

470

Describing the Performance of Cricket Bats and Balls Harsimranjeet Singh and Lloyd Smith  

E-print Network

Describing the Performance of Cricket Bats and Balls Harsimranjeet Singh and Lloyd Smith School-2920 USA Nomenclature: BBS Batted-ball speed DS Dynamic stiffness mb Cricket ball mass Fp Peak impact force vi Inbound ball speed ea Collision efficiency vb Cricket bat speed vp Cricket ball speed MOI Moment

Smith, Lloyd V.

471

Matthew B. Weinger, MD Norman Ty Smith Chair in Patient Safety & Medical Simulation  

E-print Network

Matthew B. Weinger, MD Norman Ty Smith Chair in Patient Safety & Medical Simulation Professor in Systems Safety Vanderbilt University Medical Center * and years of designing HIT too! Developing complex human-system interactions. - Greater ability & desire to customize. - Safety implications more

472

Brian Smith oral history interview by William Mansfield, October 5, 2006  

Microsoft Academic Search

Brian Smith, a county planner for Pinellas County Florida since 1970 and director of the Pinellas County Metropolitan Planning Organization, discusses his county planning experiences. He addresses issues of county and state politics, environmental land, sustainable planning, concurrency in planning, taxation, citizen participation, the interests of developers, and the process of county planning. He also discusses the Pinellas Trail, its

Brian Smith; Bill Mansfield

2006-01-01

473

Stress in Families of Young Children with Down Syndrome, Williams Syndrome, and Smith-Magenis Syndrome.  

ERIC Educational Resources Information Center

Compared stress levels in families of children with Down syndrome (DS), Williams syndrome (WS), or Smith-Magenis syndrome (SMS). Found that DS families experienced less Pessimism than others and less Parent and Family Problems than SMS families. Strongest predictors of Parent and Family Problems were maladaptive behavior in SMS, younger age in DS,…

Fidler, Deborah J.; Hodapp, Robert M.; Dykens, Elizabeth M.

2000-01-01

474

Simulation of Beach Hydraulics for Smith Island, Prince William Sound, Alaska  

Microsoft Academic Search

We investigated beach hydraulics in a gravel beach on Smith Island, Prince William Sound, Alaska that was previously polluted with the Exxon Valdez oil spill in 1989. The beach contains Heavy Oil Residue (HOR) in the lower intertidal zone. The slope of the beach decreases in the seaward direction. Measurements of water pressure and salinity were analyzed and simulated using

B. Khan; M. C. Boufadel; A. M. Bobo

2009-01-01

475

Handbook of Information and Operational Guidelines for William Smith High School.  

ERIC Educational Resources Information Center

The handbook describes the policies and philosophy of William Smith High School (Colorado), an alternative high school for students who have dropped out or had difficulty in conventional high school. Section 1 outlines the conceptual foundations of the program with information on such aspects as administration, philosophy, point system, family…

Rissler, Rolla

476

Interaction Partnering Criteria for COTS Components M. Kelkar M. Smith R. Gamble  

E-print Network

Interaction Partnering Criteria for COTS Components M. Kelkar M. Smith R. Gamble Department Commercial-off-the-Shelf (COTS) software provides a choice of products to streamline enterprise applications. COTS software integration can introduce security vulnerabilities due to mismatches between security

Gamble, R. F.

477

J. LAWRENCE SMITH AND HIS METEORITE COLLECTIONS Lee Anne Willson1  

E-print Network

and Astronomy, Iowa State University Abstract: The National Academy of Sciences awards a J. Lawrence Smith medal Academy of Science. From 1883 until 1945 just two medals were awarded; since 1985 it has been awarded, and meteorite collector. He was a member of the US National Academy of Sciences, and was President

Willson, Stephen J.

478

Smith-chart diagnostics for multi-GHz time-domain-reflectometry dielectric spectroscopy  

NASA Astrophysics Data System (ADS)

A time-domain-reflectometry Smith-chart display is demonstrated to be a valuable diagnostic tool in a variety of situations in time-domain-reflectometry dielectric spectroscopy. A relative reflection coefficient is formed by dividing the Laplace transform of the reflected sample transient by the Laplace transform of the empty-sensor transient and displaying in the complex plane, with the approximate sensor admittance read from susceptance and conductance circles. The Smith chart provides, as a diagnostic tool, an initial estimate of the dielectric behavior in the multi-GHz range and a means of identifying artifacts in acquisition and Laplace transform, in a way which does not require multiple steps of calibration and is only one step removed from the direct transient. Results are presented for a simple 3.5-mm flat sensor immersed in various liquid media, showing variations in the Smith chart for typical variations in sample permittivity, loss, and conductivity. Results are matched to vector network analyzer (VNA) measurement over an identical frequency range, as well as to finite-element field simulation. Results are also presented for a 3.5-mm sensor with various terminating pin lengths, typically employed at low frequencies and low permittivity media to increase sensor capacitance. For an unshielded pin, the Smith chart detects reflections from sample boundaries and measures the effectiveness of shielding used to eliminate these reflections. For a shielded pin, it characterizes the effect of pin length on the susceptance variation and the onset of pin resonance at high frequencies and high-permittivity values. The effect of artifacts appearing in the Smith chart on the actual calibration is shown by tracking them through the calibration process to the final result. Results are also presented for a 9-mm flat termination used for concrete hydration monitoring, showing effects of transmission-line discontinuities within a terminating plug and the onset of waveguide-like modes in a surrounding shield, with results compared to VNA measurement.

Hager, N. E.; Domszy, R. C.; Tofighi, M. R.

2012-02-01

479

The Adventures of Captain John Smith, Pocahontas and a Sundial: Cosmology, Mathematics, and Power at the Time of Jamestown  

NASA Astrophysics Data System (ADS)

While exploring the Chickahominy River in Virginia by canoe in December 1607, Captain John Smith was ambushed by 200 Powhatan Indians and chased into the swamp. Wounded by arrows and mired in the cold mud, Smith surrendered and was led to their chieftain, Opechancanough. Smith played for time. He pulled out his pocket sundial and proceeded to deliver a lecture on astronomy. The Indians marveled at the dancing needle of the magnetic compass, which they could plainly see but not touch because of the glass cover. They apparently thought less of his discourse in a foreign language on the sun, moon, and planets, as within the hour, Smith's captors had him tied to a tree and were ready to shoot him. But then, Opechancanough held the sundial aloft and spared Smith's life. For the next month, Smith was paraded around various Indian villages before being condemned to have his head bashed in. Pocahontas, however, threw herself across Smith's body in order to save his life. This legendary episode reveals more than Smith's ingenuity. His compass sundial, shaped and marked like a celestial globe, was a microcosm of his universe. It embodied the belief that the smallest things mirrored the large, that number was the key to God's creation, and that by means of mathematical instruments, men could dominate that world (or at least extricate themselves from tight spots!). This paper will examine the astronomical ideas and instruments on which these beliefs were based, and show how ultimately, Smith's sundial also represented the clash of two cosmologies-that of the Indians and European settlers.

Schechner, Sara J.

2007-12-01

480

A Review of "The Key of Green: Pasion and Perception in Renaissance Culture" by Bruce R. Smith  

E-print Network

and intellectual history. It establishes a critical agenda for studies in the history of the book for generations to come. Bruce R. Smith. The Key of Green: Passion and Perception in Renaissance Culture. Chicago: University of Chicago Press, 2009. v + 326 pp... key to a map it helps us interpret what we find there? (3). It extends to another sensory impression, Bruce R. Smith?s The Acoustic World of Early Modern Eng- land. The book, however, has ambitions beyond this thesis: hearing and especially seeing...

Clark, Ira

2009-01-01

481

Observation of copious emission at the fundamental frequency by a Smith-Purcell free-electron laser with sidewalls  

SciTech Connect

An experiment at microwave frequencies confirms the recent prediction that a Smith-Purcell [S. J. Smith and E. M. Purcell, Phys. Rev. 92, 1069 (1953)] free-electron laser equipped with sidewalls can emit radiation at the frequency of the surface wave. The power output is considerably greater than for the previously observed emission at the second harmonic, in agreement with three-dimensional simulations. The dependence of frequency on beam energy and emission angle is in good agreement with three-dimensional theory and simulations. Provided that a reduction in scale can be achieved, a path is open to coherent Smith-Purcell radiation at terahertz frequency.

Gardelle, J.; Modin, P. [CEA, CESTA, F-33114 Le Barp (France); Donohue, J. T. [Centre d'Etudes Nucleaires de Bordeaux-Gradignan, Universite Bordeaux 1, CNRS/IN2P3, BP 120, 33175 Gradignan (France)

2012-03-26

482

Evolving an Agent-Based Model to Probe Behavioral Rules in Flocks of Cowbirds V. Anne Smith1  

E-print Network

.smith@st-andrews.ac.uk Abstract Flocks of brown-headed cowbirds, Molothrus ater, self- organize social environments, which have of brown-headed cowbirds, Molothrus ater. The brown-headed cowbird is an obligate brood parasite: females

Smith, V Anne

483

78 FR 66748 - Smith Miller and Patch Inc. et al.; Proposal to Withdraw Approval of 14 New Drug Applications...  

Federal Register 2010, 2011, 2012, 2013

...NDA 004979.................. Multi-Vitamin Smith Miller and Tablets. Patch Inc., P.O. Box 367...Methischol (inositol/ USV Pharmaceutical vitamin B12/ Corp., 500 Virginia racemethionine/ Dr., Fort...

2013-11-06

484

PROPEL: An Approach Supporting Property Elucidation Rachel L. Smith, George S. Avrunin, Lori A. Clarke, and Leon J. Osterweil  

E-print Network

1 PROPEL: An Approach Supporting Property Elucidation Rachel L. Smith, George S. Avrunin, Lori A, details that need to be considered. PROPEL aims to make the job of writing and understanding properties

Massachusetts at Amherst, University of

485

76 FR 59115 - Notice of Availability of Patent Fee Changes Under the Leahy-Smith America Invents Act  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF COMMERCE Patent and Trademark Office [Docket No. PTO-P-2011-0049] Notice of Availability of Patent Fee Changes Under the Leahy- Smith America Invents Act AGENCY: United States Patent and Trademark Office, Commerce....

2011-09-23

486

Recurrent Selection for 2n Pollen Formation in Red Clover1 W. A. Parrott and R. R. Smith2  

E-print Network

DISCOVERY of 2n gametes (gametes with the Tchromosome number of the sporophyte) in red clover, Trifolium pratense L.,, and the ability to pro- duce polyploids in this species (Parrott and Smith, 1984; Parrott et

Parrott, Wayne

487

75 FR 11919 - Smith and Nephew, Inc., Wound Management-Largo Division, Including On-Site Leased Workers From...  

Federal Register 2010, 2011, 2012, 2013

...activities related to the production of advanced wound care products such as adhesive dressings, non-adhesive dressings, skin prep, skin...Florida location of Smith and Nephew, Inc., Wound Management-Largo Division. The...

2010-03-12

488

TOCTOU, Traps, and Trusted Computing Sergey Bratus, Nihal D'Cunha, Evan Sparks, and Sean W. Smith  

E-print Network

and conclusions do not necessarily represent those of the sponsors. P. Lipp, A.-R. Sadeghi, and K.-M. Koch (EdsTOCTOU, Traps, and Trusted Computing Sergey Bratus, Nihal D'Cunha, Evan Sparks, and Sean W. Smith

Smith, Sean W.

489

76 FR 55413 - Proposed Safe Harbor Agreement for California Red-legged Frog, California Tiger Salamander, Smith...  

Federal Register 2010, 2011, 2012, 2013

...Harbor Agreement for California Red-legged Frog, California Tiger Salamander, Smith's...federally threatened California red-legged frog (Rana draytonii) and California tiger...conservation of the California red-legged frog, California tiger salamander,...

2011-09-07

490

Displacement amplitude scaling of a two-dimensional synthetic jet Spencer R. Fugal, Barton L. Smith, and Robert E. Spall  

E-print Network

Displacement amplitude scaling of a two-dimensional synthetic jet Spencer R. Fugal, Barton L. Smith, and Robert E. Spall Department of Mechanical and Aerospace Engineering, Utah State University, Logan, Utah

Smith, Barton L.

491

computational infrastructure for nuclear astrophysics Michael Smith, Physics Division, Oak Ridge Na:onal Lab coordinator@nucastrodata.org  

E-print Network

computational infrastructure for nuclear astrophysics Michael Smith, Physics Division, Oak Ridge Na:onal Lab coordinator@nucastrodata.org #12;computational infrastructure for nuclear astrophysics system overview ·work with nuclear information, reaction rates, & simulations ·operates "in

492

Smith Institute: New and Emerging Themes in Industrial and Applied Mathematics (NETIAM)  

NSDL National Science Digital Library

New and Emerging Themes in Industrial and Applied Mathematics (NETIAM) is a project of the Smith Institute and supported by the European Commission's programme in New and Emerging Science and Technology (NEST). Starting in March 2004 and lasting for 15 months, the project brings together researchers from the Smith Institute, Fraunhofer-ITWM in Germany, the Technical University of Eindhoven in The Netherlands, the University of Firenze in Italy and Ventspils University College in Latvia. Using mathematical frameworks, they will identify ground-breaking research directions in four themes: modelling the business environment; modelling criminality in the social environment; visualization and simulation of materials; and complexity at the molecular level. Thematic Workshops "will exploit the brainstorming capabilities of the participants in a facilitated think-tank environment" and a final plenary workshop will report the results of their work. The website provides additional information on the project and invites researchers to join in the Thematic Workshops.

493

160-fold acceleration of the Smith-Waterman algorithm using a field programmable gate array (FPGA)  

PubMed Central

Background To infer homology and subsequently gene function, the Smith-Waterman (SW) algorithm is used to find the optimal local alignment between two sequences. When searching sequence databases that may contain hundreds of millions of sequences, this algorithm becomes computationally expensive. Results In this paper, we focused on accelerating the Smith-Waterman algorithm by using FPGA-based hardware that implemented a module for computing the score of a single cell of the SW matrix. Then using a grid of this module, the entire SW matrix was computed at the speed of field propagation through the FPGA circuit. These modifications dramatically accelerated the algorithm's computation time by up to 160 folds compared to a pure software implementation running on the same FPGA with an Altera Nios II softprocessor. Conclusion This design of FPGA accelerated hardware offers a new promising direction to seeking computation improvement of genomic database searching. PMID:17555593

Li, Isaac TS; Shum, Warren; Truong, Kevin

2007-01-01

494

Collision of the Smith Cloud and its dark matter halo with the magnetized Galactic disk  

NASA Astrophysics Data System (ADS)

The Smith Cloud is a massive High Velocity Cloud (HVC) that may have passed through the Milky Way disk in the recent past. Previous studies using hydrodynamic simulations suggest that a dark matter halo may have provided the confinement neccessary for the Smith Cloud to survive passage through the Galactic corona and disk. However, the models of the Galaxy that were used in these studies did not include a magnetic field, while magnetic fields are known to have confining properties. Other studies have shown that the Galactic magnetic field can inhibit mass exchange between the corona and the disk due to magnetic field compression. We extend upon these studies via FLASH magnetohydrodynamic simulations to consider the effects of a Galactic magnetic field on an infalling, dark matter confined HVC.

Galyardt, Jason; Shelton, Robin L.

2015-01-01

495

DNA evidence in rape cases and the Debbie Smith Act: forensic practice and criminal justice implications.  

PubMed

The Debbie Smith or "Justice for All" Act was passed on November 1, 2004. The act addresses the problem of collecting and analyzing DNA evidence from backlogged rape kits sitting in crime laboratories around the country. Presently, no empirical data exist by which to assess the soundness of the legislation. However, the act clearly affects discrete operations within the forensic and criminal justice systems. This article explores the relative merits of the Debbie Smith law, highlighting changes in Sexual Assault Nurse Examiner (SANE) programs, law enforcement, court administration, correctional treatment, and juvenile justice practices. Concerns linked to the likely impact of the "Justice for All" Act raise significant questions about its overall programmatic utility and treatment efficacy. PMID:16943376

Telsavaara, Terhi V T; Arrigo, Bruce A

2006-10-01

496

Dirt Cheap Web-Scale Parallel Text from the Common Crawl Jason R. Smith1,2  

E-print Network

Dirt Cheap Web-Scale Parallel Text from the Common Crawl Jason R. Smith1,2 jsmith@cs.jhu.edu Magdalena Plamada4 plamada@cl.uzh.ch Adam Lopez1,2 alopez@cs.jhu.edu 1 Department of Computer Science, Johns) or Wikipedia (Smith et al., 2010)-- it is common to find document pairs that are di- rect translations of one

Callison-Burch, Chris

497

Endogenous cytokinin distribution patterns at budburst in Granny Smith and Braeburn apple shoots in relation to bud growth  

Microsoft Academic Search

The possible relationship of branching habit to cytokinin content of apple shoots (Malus×domestica Borkh.) was investigated. One-year old apple shoots are acrotonic (distal branching), more strongly so in Granny Smith than in Braeburn. In the first trial, long, 1-year old Granny Smith and Braeburn apple shoots were sprayed on 29 August 1995 to break rest with dinitro-o-cresol (DNOC) oil (5%).

Nigel C. Cook; Dirk U. Bellstedt; Gerard Jacobs

2001-01-01

498

Differential resistance of switchgrass Panicum virgatum L. lines to fall armyworms Spodoptera frugiperda (J. E. Smith)  

Microsoft Academic Search

Six cultivars of switchgrass Panicum virgatum L., a plant native to North America that has potential as a bioenergy source, were evaluated for resistance to feeding by\\u000a the fall armyworm Spodoptera frugiperda (J. E. Smith). Although no mortality was noted, seedlings of the cultivar ‘Trailblazer’ and older plants of the cultivar\\u000a ‘Blackwell’ were among the most resistant to feeding by

Patrick F. Dowd; Eric T. Johnson

2009-01-01

499

BLAZETM: An Implementation of the Smith-Waterman Sequence Comparison Algorithm on a Massively Parallel Computer  

Microsoft Academic Search

We have implemented the Smith and Waterman dynamic programming algorithm on the massively parallel MP1104 computer from MasPar and compared its ability to detect remote protein sequence homologies with that of other commonly used database search algorithms. Dynamic programming algorithms are normally too computer intensive to permit full databases search, however on the MP1104 a search of the Swiss-Prot database

Douglas L. Brutlag; Jean-pierre Dautricourt; Ron Diaz; Jeff Fier; Bruce Moxon; Richard Stamm

1993-01-01

500

Enhanced Superradiant Smith–Purcell Radiation in a Three-Mirror Quasi-Optical Cavity  

Microsoft Academic Search

Smith-Purcell (SP) radiation has been widely used for the generation of radiation from microwave to optical frequencies, and it has recently become an attractive candidate for a Terahertz (THz) radiation source. Superradiant SP radiation has sharp angular and spectral distributions due to the bunching of the electron beams, and a three-mirror quasi-optical cavity (TMQOC) which has selectivity at both angles

Yong Yin; Huashen Chen

2009-01-01