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Sample records for glaxo smith kline

  1. Scientists in Sport, the 2012-Inspired GlaxoSmithKline Schools Outreach Programme

    ERIC Educational Resources Information Center

    Gadd, Mark

    2012-01-01

    The GlaxoSmithKline Scientists in Sport team have worked with 4science to provide resources and offer activities for use by schools to show the relevance of science in sport. Much of the content looks at anti-doping and the science involved with detecting the misuse of banned substances. Through the development of a website, this work can continue…

  2. 78 FR 63226 - GlaxoSmithKline LLC; Withdrawal of Approval of the Indication for Treatment of Patients With...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-23

    ... patients who have not received prior rituximab (the rituximab-na ve indication) under the Agency's..., FDA requested that Glaxo voluntarily withdraw the rituximab-na ve indication for BEXXAR (tositumomab... approval of the rituximab-na ve indication does not otherwise affect the approved indication for...

  3. 78 FR 63226 - GlaxoSmithKline LLC; Withdrawal of Approval of the Indication for Treatment of Patients With...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-23

    ...rituximab, for BEXXAR (tositumomab and iodine I 131 tositumomab) Injection held by...indication for BEXXAR (tositumomab and iodine I 131 tositumomab) Injection because...indication for BEXXAR (tositumomab and iodine I 131 tositumomab) Injection from...

  4. Feasibility Study of GlaxoSmithKline Biologicals' GSK2202083A Vaccine in Healthy Infants at 3, 5 and 11 Months of Age.

    ClinicalTrials.gov

    2012-11-16

    Haemophilus Influenzae Type b; Poliomyelitis; Hepatitis B; Serogroup C Meningococcal Diseases; Diphtheria; Pertussis; Diphtheria-Tetanus-aPertussis-Hepatitis B-Poliomyelitis-Haemophilus Influenzae Type b-Neisseria Meningitidis Vaccines; Tetanus

  5. The SmithKline Beecham 'quality of life' scale: a validation and reliability study in patients with affective disorder.

    PubMed

    Stoker, M J; Dunbar, G C; Beaumont, G

    1992-12-01

    The rationale for the development of Repertory-Grid based quality of life assessment (QOL) is described. The emergent scale, the SmithKline Beecham Quality of Life Scale (SBQOL) utilizes 23 predetermined constructs and three fixed elements: self now, ideal self and sick self. Inclusion of the latter two elements provides a personal frame of reference for the individual and recognizes the highly idiosyncratic and subjective nature of the experience which constitutes quality of life. A study of the validity and reliability of the SBQOL was conducted in 129 patients presenting to their GP with either major depression or generalized anxiety disorder, as defined by DSM III R. Patients were treated at the discretion of their GP and followed over a period of 12 weeks with assessments of treatment efficacy being performed at 6 weeks and 12 weeks in parallel with administration of the SBQOL. The results from co-administration of standard efficacy measures such as the Hamilton Depression Rating Scale (HAMD) and Hamilton Anxiety Scale (HAMA) with the SBQOL, provided good evidence of construct validity. Evidence in support of the concurrent validity of the SBQOL was provided by co-administration of the Sickness Impact Profile and General Health Questionnaire (external criteria) with the SBQOL scale. Test-retest reliability and internal consistency were high. No obvious advantage was conferred by the use of principal components analysis from the Flexigrid software package in contrast to a simple arithmetical procedure for computing interelement distances. It is concluded that the SBQOL provides a valid, reliable and practicable approach to the assessment of quality of life in patients with affective disorder. PMID:1299471

  6. Zanamivir (Glaxo Wellcome).

    PubMed

    Oxford, J S

    2000-04-01

    Zanamivir, a neuraminidase inhibitor under license from Biota, has been developed and launched by Glaxo Wellcome for the treatment of influenza virus infection [277127]. While registered as drugs, neuraminidase inhibitors are technically vaccines as they are believed to work by provoking an immune response, thus preventing the spread of infection from one cell to another within the respiratory tract [314356]. It is administered, using an inhaler, directly to where the virus replicates, minimizing the potential for side effects. Zanamivir has been launched, under the name Relenza, for the treatment of influenza in Australia [325148], New Zealand [335591] and the UK [341871]. It is registered in Mexico and Armenia [346474], and approved in Japan [351580]. In October 1999, it was launched in the US [352392] and Glaxo confirmed in January 2000, that zanamivir has been launched all over Europe, with the exception of Greece and Spain, where launch is imminent [352513]. In October 1999, the British Pharma Group (BPG) wrote to the UK Prime Minister to seek a discussion on the implications for the British-based pharmaceutical industry of the recommendation from NICE's Raised Appraisal Committee that Relenza should be banned from the NHS [342597]. An FDA submission was made in October 1998 [302732,304779]; the FDA advisory committee met on February 24 1999 to discuss the application [313583]. The Antivirals Drugs Advisory Committee voted against recommending zanamivir for FDA approval [316196]. Members suggested that additional studies using a different endpoint or targeting specific high-risk populations would be more likely to garner support [317454]. Following a discussion with Glaxo Wellcome in April 1999, the FDA indicated that it would continue to review the NDA for zanamivir [320565]. In July 1999, the company received final FDA approval for the drug for the treatment of both influenza A and B [334127], and aimed to initiate a phase IV trial program for the detection of consumer problems with the product, following launch of the product in time for the 1999-2000 flu season [352392,335048]. In September 1998, Glaxo applied to the Canadian Health Protection Branch (HPB) for approval to market zanamivir for the treatment and prevention of influenza. A separate application for Fast Track approval was also made with the HPB [299375,299472]. In November 1999, zanamivir received approval in Canada [346474]. Glaxo expects to make MAA and NDA filings for the use of zanamivir as a prophylactic in 1999 [333494]. In July 1998, Merrill Lynch predicted that as zanamivir offered only modest benefits gained from a narrow treatment window, potential would be limited and forecast annual sales of US dollar 30 million [302048]. In January 1999, Paribas predicted sales of pounds 75 million in 1999, rising to pounds 280 million in 2003 [317650]. In April 1999, ABN Amro predicted sales of pounds 23 million in 1999, rising to pounds 326 million in 2003 [328676]. In August 1999, Lehman Brothers estimated that sales of zanamivir will reach US dollar 400 million by 2003, and that it is an obvious candidate for an OTC switch, although this is not likely until 5 years after launch [336356]. PMID:16100701

  7. Pharma giants swap research programs.

    PubMed

    2014-07-01

    Pharmaceutical giants Novartis and GlaxoSmithKline (GSK) agreed in late April to swap some assets, with Novartis handing off its vaccine business to GSK and getting most of the British company's cancer portfolio in return. PMID:25002632

  8. 75 FR 32189 - Joint Meeting of the Endocrinologic and Metabolic Drugs Advisory Committee and the Drug Safety...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-07

    ...maleate) Tablets, GlaxoSmithKline, a drug approved for blood glucose control in adults with type 2 diabetes mellitus. Data specific to rosiglitazone...meta-analyses performed on each of these two drugs. FDA intends to make background...

  9. Keith L. Kline Climate Change Science Institute,

    E-print Network

    Post, Wilfred M.

    , Sustainability Criteria for Bioenergy and Member of the American Society for Testing and Materials (ASTM Society of America), Environmental Modeling and Software, Environmental Impact Assessment Review, Biofuels-American Development Bank, and others (2014). Publications (20 recent examples) 1. Kang, S., Singh N, Kline KL, Nichols

  10. 76 FR 1181 - Oncologic Drugs Advisory Committee; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-07

    ...irinotecan alone is ineffective or less effective; (2) supplemental BLA (sBLA) 125011/24, trade name BEXXAR (tositumomab and Iodine I 131 tositumomab), application submitted by SmithKline Beecham Corp. doing business as (d/b/a) GlaxoSmithKline,...

  11. 77 FR 32125 - Oncologic Drugs Advisory Committee; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-31

    ...application (sNDA) 022059/014 with the trade name Tykerb (lapatinib) tablets, application submitted by SmithKline Beecham (Cork) Ltd, Ireland d/b/a GlaxoSmithKline. The proposed indication (use) for this product is in combination with...

  12. Prairies and Savannas of Wisconsin Lecture Series by Virginia Kline

    E-print Network

    Emshwiller, Eve

    Prairies and Savannas of Wisconsin Lecture Series by Virginia Kline · Prairies and Savannas, Reading the Landscape: Wisconsin's Prairies and Savannas. Audio was taped during the course taught-7. A few images are from the Atlas of Wisconsin Prairie and Savanna Flora by Theodore Cochrane and Hugh

  13. Smith Residence 

    E-print Network

    Raiford Stripling Associates, Inc.; Stripling, Raiford L.

    1955-01-01

    concept (1897), many ecologists have followed the former perspective (e.g., Watt & Jones 1948; Gedalof, & Smith 2001; Cripps & Eddington 2005), though some scholars have focused their research efforts on the latter (e.g., Lauer & Klaus 1975; Churkina... & Svirezhev 1995; Hattenschwiler & Smith 1999; Oksanen & Minchin 2002) (Kark & van Rensburg 2006). In some extreme instances, several ecologists that 6 published their work in the preeminent journal Ecology (e.g., Driscoll 1964; Allan et al. 1973...

  14. M.C. Kline BERM 10 Providing SRMs for the Rapidly Evolving Forensic DNA & Human

    E-print Network

    (along with allele sharing from autosomal STRs) Butler, J.M. (2005) Forensic DNA Typing, 2nd Edition, BoxM.C. Kline ­ BERM 10 Providing SRMs for the Rapidly Evolving Forensic DNA & Human Identity Testing Evolving Forensic DNA & Human Identity Testing Communities Margaret Kline, David Duewer, and John Butler

  15. M.C. Kline PITTCON 2006 Forensic DNA Standard Reference Materials

    E-print Network

    . Butler, J.M. (2005) Forensic DNA Typing, 2nd Edition, Box 10.1, pp. 250-251 Quality Is EssentialM.C. Kline ­ PITTCON 2006 Forensic DNA Standard Reference Materials March 12, 2006 http://www.cstl.nist.gov/biotech/strbase/NISTpub.htm 1 Forensic DNA Standard Reference Materials Margaret C. Kline and John Butler National Institute

  16. M.C. Kline Biological Evidence Preservation TWG DNA Science Update

    E-print Network

    M.C. Kline ­ Biological Evidence Preservation TWG DNA Science Update August 17, 2010 http://www.cstl.nist.gov/biotech/strbase/NISTpub.htm 1 DNA Science Update Margaret C. Kline NIST Applied Genetics Group Biochemical Science Division NIST and Technology. Certain commercial equipment, instruments and materials are identified in order to specify

  17. k-line iterative methods: a conjugate-gradient approach

    SciTech Connect

    Kratzer, D.; Parter, S.V.; Steuerwalt, M.

    1981-03-29

    The generalized conjugate gradient scheme based on the k-line block Jacobi splitting A = M-N was studied for solving model two-dimensional parabolic and elliptic difference equations AU = F tilde. A represents the matrix ch/sup ..cap alpha../-h/sup 2/..delta../sub h/. Eigenvalues of M/sup -1/N cluster, and the cluster radii decrease as ch/sup ..cap alpha../ or k increases. Computations with k = 4, 8, 16, 32, and ch/sup ..cap alpha../ = 0, h, 2 are discussed.

  18. Recognizing Your Support Special thanks to alumni, staff, faculty and friends who support the School of Dental Medicine. Their

    E-print Network

    Krovi, Venkat

    the School of Dental Medicine. Their generosity helps sustain the tradition of philanthropy and excellence Judith M. Collord Delta Dental Community Care Foundation Allen L. Finkelstein GlaxoSmithKline Charles P Dental Group, PC $2,500 - $4,999 American Academy of Fixed Prosthodontics Richard F. Andolina Sr., DDS

  19. FUNDED BY NATIONAL SECURITY AGENCY SATURDAY, APRIL 18, 2015

    E-print Network

    Suri, Manil

    FUNDED BY NATIONAL SECURITY AGENCY SATURDAY, APRIL 18, 2015 INFORMATION TECHNOLOGY/ENGINEERING (ITE Guha, Texas A & M University Rupa Mitra, Community College of Baltimore County Anna Sun, Food Bureau Lei Nie, Food and Drug Administration Gitanjali Paul, GlaxoSmithKline (GSK) Yaser Samadi

  20. Principles of pharmacological modelling relevant to applications of imaging endpoints

    E-print Network

    Johansen, Adam

    Principles of pharmacological modelling relevant to applications of imaging endpoints Chao Chen and Stefano Zamuner Clinical Pharmacology Modelling and Simulation GlaxoSmithKline London, UK FP7 Neurophysics WORKSHOP: Pharmacological fMRI. University of Warwick, UK. 23-24 Jan 2012 #12;outline · Modelling

  1. Applications of Evolutionary Computing, Gunther R. Raidl et. al. editors, Essex, UK 1416 April 2003, LNCS 2611, pp8798, Springer-Verlag

    E-print Network

    Fernandez, Thomas

    from Glaxo SmithKline (GSK)'s cheminformatics database. The receiver operating characteristics (ROC to the point of critical depen- dence upon computerised systems, databases and newer disciplines related-Throughput Screening (HTS), and increasingly Ultra-HTS, are resource- intensive. Models developed from diverse sets

  2. Disconnected Youth in the Research Triangle Region: An Ominous Problem Hidden in Plain Sight

    ERIC Educational Resources Information Center

    Dodson, David; Guillory, Ferrel; Lipsitz, Joan; Raper, Noah; Rausch, Christina

    2008-01-01

    In September 2006, the North Carolina GlaxoSmithKline Foundation commissioned MDC, Inc. of Chapel Hill to analyze the problem of "disconnected youth" in the Research Triangle region, determine the current state of the region's responses to the challenge, and recommend steps to deepen and accelerate action on the issue. The research process was…

  3. 76 FR 12022 - Foreign-Trade Zone 147-Berks County, PA; Site Renumbering Notice; Correction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-04

    ... Federal Register notice (76 FR 1134, 1/7/11) describing the renumbering of sites within Foreign-Trade Zone... 20 (14.5 acres)--GlaxoSmithKline, 105 Willow Springs Lane, York; Site 21 (4.4 acres)--Southern...

  4. 75 FR 17929 - Vaccines and Related Biological Products Advisory Committee; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-08

    ... SERVICES Food and Drug Administration Vaccines and Related Biological Products Advisory Committee; Notice... be open to the public. Name of Committee: Vaccines and Related Biological Products Advisory Committee... circovirus type 1 (PCV 1) in Rotarix, a U.S. licensed vaccine manufactured by GlaxoSmithKline and...

  5. 77 FR 63839 - Vaccines and Related Biological Products Advisory Committee; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-17

    ... HUMAN SERVICES Food and Drug Administration Vaccines and Related Biological Products Advisory Committee... be open to the public. Name of Committee: Vaccines and Related Biological Products Advisory Committee... immunogenicity of an Influenza A (H5N1) Virus Monovalent Vaccine manufactured by GlaxoSmithKline. On November...

  6. 75 FR 17929 - Vaccines and Related Biological Products Advisory Committee; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-08

    ...the morning, the committee will review and discuss available data regarding the unexpected finding of DNA originating from porcine circovirus type 1 (PCV 1) in Rotarix, a U.S. licensed vaccine manufactured by GlaxoSmithKline and indicated for the...

  7. Application for The Jonathan K. Perryman Memorial Scholarship for the Physical Sciences

    E-print Network

    Neufeld, Howard S.

    Application for The Jonathan K. Perryman Memorial Scholarship for the Physical Sciences The Glaxo Smith Kline Women in Science Scholarship Program The Peggy Harmon Shore Pre-Health Care Professional Scholarship Applicants for the above scholarships must submit the following application and an unofficial

  8. Surface Localization Determinants of Borrelia burgdorferi Lipoproteins

    E-print Network

    Kumru, Ozan

    2011-02-25

    : Introduction………………………………………………………................. 1 Lyme disease………………………………………………………………………............ 3 Lyme disease vaccination…………………………………………………………............. 6 Tick Borne relapsing fever…………………………………………………………………. 9 Antigenic Variation and Tissue... in this study. ………………………...…….. 118 6.3. Localization of Lpp in B. burgdorferi…………………………………………........... 119 ix Abbreviations LD: Lyme disease TBRF: Tick borne relapsing fever GSK: GlaxoSmithKline BSK: Barbour-Stoenner-Kelly LB: Lysogeny broth...

  9. PowerPoint Presentation

    Cancer.gov

    • Journal of the National Cancer Institute, ePub January 7, 2013; print: February, 2013 (issue 3) Disclosure • I am an inventor of NIH vaccine technology that has been licensed to Merck and GlaxoSmithKline, the two companies that manufacture the

  10. A Unifying Framework for Measuring Weighted Rich Clubs

    E-print Network

    Alstott, Jeff; Panzarasa, Pietro; Rubinov, Mikail; Bullmore, Edward T.; Vértes, Petra E.

    2014-12-01

    -Oxford-Cambridge Scholarship Program. P.P. is employed byQueenMaryUniversity of London. M.R. is supported by the NARSAD Young Investigator and Isaac Newton Trust grants. E.T.B. is employed half-time by the University of Cambridge, UK, and half-time by GlaxoSmithKline (GSK). P...

  11. Stephen Jay Kline on systems, or physics, complex systems, and the gap between.

    SciTech Connect

    Campbell, Philip LaRoche

    2011-06-01

    At the end of his life, Stephen Jay Kline, longtime professor of mechanical engineering at Stanford University, completed a book on how to address complex systems. The title of the book is 'Conceptual Foundations of Multi-Disciplinary Thinking' (1995), but the topic of the book is systems. Kline first establishes certain limits that are characteristic of our conscious minds. Kline then establishes a complexity measure for systems and uses that complexity measure to develop a hierarchy of systems. Kline then argues that our minds, due to their characteristic limitations, are unable to model the complex systems in that hierarchy. Computers are of no help to us here. Our attempts at modeling these complex systems are based on the way we successfully model some simple systems, in particular, 'inert, naturally-occurring' objects and processes, such as what is the focus of physics. But complex systems overwhelm such attempts. As a result, the best we can do in working with these complex systems is to use a heuristic, what Kline calls the 'Guideline for Complex Systems.' Kline documents the problems that have developed due to 'oversimple' system models and from the inappropriate application of a system model from one domain to another. One prominent such problem is the Procrustean attempt to make the disciplines that deal with complex systems be 'physics-like.' Physics deals with simple systems, not complex ones, using Kline's complexity measure. The models that physics has developed are inappropriate for complex systems. Kline documents a number of the wasteful and dangerous fallacies of this type.

  12. Mathematical Robert Smith?

    E-print Network

    Maini, Philip K.

    Mathematical Modelling of Zombies Robert Smith? University of Ottawa Press #12;Robert Smith? Mathematical Modelling of Zombies University of Ottawa Press|2014 #12;The University of Ottawa Press. Library and Archives Canada Cataloguing in Publication Mathematical modelling of zombies / edited

  13. Absence epileptic activity changing effects of non-adenosine nucleoside inosine, guanosine and uridine in Wistar Albino Glaxo Rijswijk rats.

    PubMed

    Kovács, Z; Kékesi, K A; Dobolyi, Á; Lakatos, R; Juhász, G

    2015-08-01

    Adenosine (Ado) and non-adenosine (non-Ado) nucleosides such as inosine (Ino), guanosine (Guo) and uridine (Urd) may have regionally different roles in the regulation of physiological and pathophysiological processes in the central nervous system (CNS) such as epilepsy. It was demonstrated previously that Ino and Guo decreased quinolinic acid (QA)-induced seizures and Urd reduced penicillin-, bicuculline- and pentylenetetrazole (PTZ)-induced seizures. It has also been demonstrated that Ino and Urd may exert their effects through GABAergic system by altering the function of GABA(A) type of gamma-aminobutyric acid receptors (GABAA receptors) whereas Guo decreases glutamate-induced excitability through glutamatergic system, which systems (GABAergic and glutamatergic) are involved in pathomechanisms of absence epilepsy. Thus, we hypothesized that Ino and Guo, similarly to the previously described effect of Urd, might also decrease absence epileptic activity. We investigated in the present study whether intraperitoneal (i.p.) application of Ino (500 and 1000mg/kg), Guo (20 and 50mg/kg), Urd (500 and 1000mg/kg), GABA(A) receptor agonist muscimol (1 and 3mg/kg), GABA(A) receptor antagonist bicuculline (2 and 4mg/kg), non-selective Ado receptor antagonist theophylline (5 and 10mg/kg) and non-competitive N-methyl-d-aspartate (NMDA) receptor antagonist (+)-5-methyl-10,11-dihydro-5H-dibenzo (a,d) cyclohepten-5,10-imine maleate (MK-801, 0.0625 and 0.1250mg/kg) alone and in combination have modulatory effects on absence epileptic activity in Wistar Albino Glaxo Rijswijk (WAG/Rij) rats. We found that Guo decreased the number of spike-wave discharges (SWDs) whereas Ino increased it dose-dependently. We strengthened that Urd can decrease absence epileptic activity. Our results suggest that Guo, Urd and their analogs could be potentially effective drugs for treatment of human absence epilepsy. PMID:26037802

  14. Communicating About Bioenergy Sustainability Virginia H. Dale Keith L. Kline Donna Perla

    E-print Network

    Pennycook, Steve

    Communicating About Bioenergy Sustainability Virginia H. Dale · Keith L. Kline · Donna Perla · Al on ``Sustainability of Bioenergy Systems: Cradle to Grave'' because scientific communication is essential the effects of bioenergy can be assessed and compared to other energy alternatives to foster sustainability

  15. Kline Progress Toward SRM 2372 NIJ DNA Grantees meeting (Crystal City, VA)

    E-print Network

    Kline ­ Progress Toward SRM 2372 NIJ DNA Grantees meeting (Crystal City, VA) June 26, 2006 http.05 ng/µL labs recovered 73% more DNA from a Teflon tube than from a polypropylene tube. · The "new" q DNA Grantees meeting (Crystal City, VA) June 26, 2006 http

  16. M.C. Kline SRM 2372 Characterization and Use MAAFS Meeting (Washington, DC)

    E-print Network

    M.C. Kline ­ SRM 2372 Characterization and Use MAAFS Meeting (Washington, DC) May 25, 2007 http. Decker, Janette W. Redman, and John M. Butler 2007 MAAFS Meeting May 23, 2007, Washington, DC National Meeting (Washington, DC) May 25, 2007 http://www.cstl.nist.gov/biotech/strbase/NISTpub.htm 2 National

  17. Variability of Solar UV Irradiance Related to Bright Magnetic Features Observed in Call K-Line: Relationship between Lyman alpha and K-line Report for UARS funding agency

    NASA Technical Reports Server (NTRS)

    Zirin, Harold; Cameron, Robert

    1999-01-01

    In this report we comment on the relationship between the Lyman alpha and Calcium K-line emission from the Sun. We firstly examine resolved Lyman alpha images (from TRACE) and resolved K-line images. We find that the Lyman alpha emission is consistent with a linear dependence on the K-line emission. As this is in conflict with the analysis of Johannesson et al.(1995, 1998) we proceed by comparing the disk integrated Lyman alpha flux as a function of ratio between the disk integrated Mg II core and wing fluxes (Johannesson et al (1998) having previously found a linear dependence between this index and the BBSO K-line index). We find that a reasonably good fit can be obtained, however note the discrepancies which lead Johannesson et al to consider the square root relationship. We suggest an alternative interpretation of the discrepancy.

  18. Smith Tackles Oakland Unified

    ERIC Educational Resources Information Center

    Mellon, Ericka

    2011-01-01

    As a 20-something, Anthony "Tony" Smith had fulfilled one dream: playing professional football for the Green Bay Packers and the San Francisco 49ers. Next up, he thought, was law school, but a former mentor reminded him that he is a teacher. Smith never became a classroom teacher, but his background in sports--where he learned the power of…

  19. http://www.cstl.nist.gov/biotech/strbase/NISTpub.htm September 28, 2003 Margaret Kline 1

    E-print Network

    Cataloging and Characterization · SRM 2395 Y-Chromosome Standard · mtDNA Typing Work · miniSTR Work · Future://www.cstl.nist.gov/biotech/strbase/NISTpub.htm September 28, 2003 Margaret Kline 2 New Y-Chromosome NIST SRM Come see Poster #32 on NIST SRM 2395 and Other Y-Chromosome Work Human Y-Chromosome DNA Profiling Standard ·5 male samples + 1 female sample (neg

  20. Carrington Maps of Ca II K-line Emission for the Years 1915-1985

    NASA Astrophysics Data System (ADS)

    Sheeley, N. R., Jr.; Cooper, T. J.; Anderson, J. R. L.

    2011-03-01

    We have used Mount Wilson Observatory calcium K-line images, digitized and flat fielded by the solar group at UCLA, to construct Carrington maps of Ca II 3934 Å intensity for the years 1915-1985. These maps have a spatial resolution comparable to the resolution of Carrington maps of the magnetic field observed at Kitt Peak and a spectral resolution comparable to the width of the K232 emission. Consequently, they provide a way of tracking the spatial distribution of magnetic flux from the present back to the year 1915. In this paper, we compare some of the recent K-line maps with corresponding maps of magnetic field, and show examples of K-line maps during earlier sunspot cycles when high-quality magnetograms were not available. Then, we use butterfly diagrams and super-synoptic displays to summarize the long-term evolution of the patterns of calcium intensity. Although each cycle has characteristics that are similar to the others, cycle 19 is remarkable for its broad latitudinal distribution of active regions, for its giant poleward surges of flux, and for the emergence of a north-south asymmetry that lasted 10 years.

  1. Earl "Bama" Smith 

    E-print Network

    Unknown

    2011-08-17

    , these include the cost of advertising for replacement, the replacement and training the new hires and the lag in productivity because of replacement (Cascio, 2007; Flamholtz, 1999; Smith & Watkins, 1978). Despite hiring well educated and trained workers...

  2. Can the Validation Process in Forensic DNA Typing Be Standardized? Butler, Tomsey, and Kline International Symposium on Human Identification (October 6, 2004) Page 1 of 20

    E-print Network

    Can the Validation Process in Forensic DNA Typing Be Standardized? Butler, Tomsey, and Kline 15th in Forensic DNA Typing Be Standardized? John M. Butler1 , Christine S. Tomsey2 , Margaret C. Kline1 1 National of the forensic DNA typing community. The survey summaries found that a wide range of responses exist throughout

  3. An Atlas of K-line Spectra for Cool Magnetic CP Stars: The Wing-Nib Anomaly (WNA)

    E-print Network

    C. R. Cowley; S. Hubrig; I. Kamp

    2005-12-11

    We present a short atlas illustrating the unusual Ca {\\sc ii} K-line profiles in upper main sequence stars with anomalous abundances. Slopes of the profiles for 10 cool, magnetic chemically peculiar (CP) stars change abruptly at the very core, forming a deep "nib." The nibs show the same or nearly the same radial velocity as the other atomic lines. The near wings are generally more shallow than in normal stars. In three magnetic CP stars, the K-lines are too weak to show this shape, though the nibs themselves are arguably present. The Ca {\\sc ii} H-lines also show deep nibs, but the profiles are complicated by the nearby, strong H$\\epsilon$ absorption. The K-line structure is nearly unchanged with phase in $\\beta$ CrB and $\\alpha$ Cir. Calculations, including NLTE, show that other possibilities in addition to chemical stratification may yield nib-like cores.

  4. Smith Normal Form and Combinatorics

    E-print Network

    normal form (SNF) of A. Smith Normal Form and Combinatorics ­ p. 2 #12;Smith normal form A: n × n matrix, . . . d1d2 · · · dn), where di R. We then call B a Smith normal form (SNF) of A. NOTE. (1) Can extend to m × n. (2) unit · det(A) = det(B) = dn 1 dn-1 2 · · · dn. Thus SNF is a refinement of det. Smith

  5. Modulatory effects of inosine, guanosine and uridine on lipopolysaccharide-evoked increase in spike-wave discharge activity in Wistar Albino Glaxo/Rijswijk rats.

    PubMed

    Kovács, Zsolt; Kékesi, Katalin A; Juhász, Gábor; Dobolyi, Arpád

    2015-09-01

    We showed previously that the number of spike-wave discharges (SWDs) was increased after intraperitoneal (i.p.) injection of lipopolysaccharide (LPS), inosine (Ino) and muscimol alone whereas i.p. guanosine (Guo), uridine (Urd), bicuculline, theophylline and (+)-5-methyl-10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5,10-imine maleate (MK-801) alone decreased the SWD number in Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats. These drugs may exert their effects on absence epileptic activity mainly via proinflammatory cytokines-evoked increase in cortical excitability (such as LPS), GABAergic system (LPS, Ino, Urd, muscimol and bicuculline), glutamatergic system (LPS, Guo and MK-801) and adenosinergic system (LPS, Ino, Guo, Urd and theophylline). Both GABAergic system and glutamatergic system are involved in the pathomechanism of absence epilepsy, the LPS-evoked increase in absence epileptic activity and the pro- or antiepileptic effects of non-adenosine (non-Ado) nucleosides Ino, Guo and Urd. Moreover, Ino, Guo and Urd have modulatory effects on inflammatory processes. Thus, we investigated whether Ino, Guo and Urd have also modulatory influence on LPS-evoked increase in SWD number using two different concentrations of each nucleoside in WAG/Rij rats. We demonstrated that Ino dose-dependently aggravated whereas Guo and Urd attenuated the LPS-evoked increase in SWD number. Our results suggest that different nucleosides have diverse effects on LPS-induced changes in absence epileptic activity. PMID:26365718

  6. Smith Normal Form and Combinatorics

    E-print Network

    ) such that PAQ := B = diag(d1, d1d2, . . . d1d2 · · · dn), where di R. We then call B a Smith normal form (SNF · · · dn), where di R. We then call B a Smith normal form (SNF) of A. NOTE. (1) Can extend to m × n. (2) unit · det(A) = det(B) = dn 1 dn-1 2 · · · dn. Thus SNF is a refinement of det. Smith Normal Form

  7. Presented by Jeremy C. Smith

    E-print Network

    ;2 Managed by UT-Battelle for the U.S. Department of Energy Smith_Biosystems_SC10 Simulation model and Computation, DOI: 10.1021/ct900292r #12;3 Managed by UT-Battelle for the U.S. Department of Energy Smith by UT-Battelle for the U.S. Department of Energy Smith_Biosystems_SC10 Shape of surface invariant under

  8. Solar Cycle Fine Structure and Surface Rotation from Ca II K-Line Time Series Data

    NASA Technical Reports Server (NTRS)

    Scargle, Jeff; Keil, Steve; Worden, Pete

    2011-01-01

    Analysis of three and a half decades of data from the NSO/AFRL/Sac Peak K-line monitoring program yields evidence for four components to the variation: (a) the solar cycle, with considerable fine structure and a quasi-periodicity of 122.4 days; (b) a stochastic process, faster than (a) and largely independent of it, (c) a quasi-periodic signal due to rotational modulation, and of course (d) observational errors (shown to be quite small). Correlation and power spectrum analyses elucidate periodic and aperiodic variation of these chromospheric parameters. Time-frequency analysis is especially useful for extracting information about differential rotation, and in particular elucidates the connection between its behavior and fine structure of the solar cycle on approximately one-year time scales. These results further suggest that similar analyses will be useful at detecting and characterizing differential rotation in stars from stellar light-curves such as those being produced at NASA's Kepler observatory.

  9. Solar Cycle Variability and Surface Differential Rotation from Ca II K-Line Time Series Data

    E-print Network

    Scargle, Jeffrey; Worden, Pete

    2013-01-01

    Analysis of over 36 years of time series data from the NSO/AFRL/Sac Peak K-line monitoring program elucidates five components of the variation of the seven measured chromospheric parameters: (a) the solar cycle (period ~ 11 years), (b) quasi-periodic variations (periods ~100 days), (c) a broad band stochastic process (wide range of periods), (d) rotational modulation, and (e) random observational errors, independent of (a)-(d). Correlation and power spectrum analyses elucidate periodic and aperiodic variation of these parameters. Time-frequency analysis illuminates periodic and quasi periodic signals, details of frequency modulation due to differential rotation, and in particular elucidates the rather complex harmonic structure (a) and (b) at time scales in the range ~0.1 - 10 years. These results using only full-disk data suggest that similar analyses will be useful at detecting and characterizing differential rotation in stars from stellar light-curves such as thosebeing produced by NASA's Kepler observator...

  10. 78 FR 54903 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

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  1. 78 FR 39757 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

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  18. Genetics Home Reference: Smith-Magenis syndrome

    MedlinePLUS

    ... PubMed Recent literature OMIM Genetic disorder catalog Conditions > Smith-Magenis syndrome On this page: Description Genetic changes ... names Glossary definitions Reviewed December 2013 What is Smith-Magenis syndrome? Smith-Magenis syndrome is a developmental ...

  19. Study of K-line radiation of thick titanium produced in collisions of keV electrons.

    PubMed

    Yadav, Namita; Bhatt, Pragya; Singh, Raj; Llovet, X; Shanker, R

    2011-10-01

    The characteristic K-line yields Y(E?) of a pure thick titanium (Z=22) element target are measured for 8-18 keV electron impact and compared with the simulation calculations using PENELOPE code. A fair agreement between experiment and simulation results is found within the existing experimental uncertainty of measurements. The ratio F of indirectly produced characteristic Ti K X-ray yield to its total (directly+indirectly) yield is determined by employing an approximate analytical formulation of Hanson and Cowan (Hanson, H.P., Cowan, D.J., 1961. Phys. Rev. 124, 22-26). It is found that F changes strongly with impact energy E? for normal angle of incidence in contrast to a mild change predicted by the simulation calculations. Furthermore, experimental and simulation results for peak to effective continuum ratio R of Ti K-line are compared and discussed for the energy range of impact of the present investigation. PMID:21723738

  20. Smith normal form Incidence of Subspaces

    E-print Network

    Arnold, Elizabeth A.

    Smith normal form Incidence of Subspaces Incidence maps and SNF bases The Smith Normal Form SNF of Skew Lines in PG(3, q) #12;Smith normal form Incidence of Subspaces Incidence maps and SNF bases Outline 1 Smith normal form 2 Incidence of Subspaces 3 Incidence maps and SNF bases Brouwer, Ducey

  1. SOLAR CYCLE VARIABILITY AND SURFACE DIFFERENTIAL ROTATION FROM Ca II K-LINE TIME SERIES DATA

    SciTech Connect

    Scargle, Jeffrey D.; Worden, Simon P.; Keil, Stephen L.

    2013-07-01

    Analysis of over 36 yr of time series data from the NSO/AFRL/Sac Peak K-line monitoring program elucidates 5 components of the variation of the 7 measured chromospheric parameters: (a) the solar cycle (period {approx} 11 yr), (b) quasi-periodic variations (periods {approx} 100 days), (c) a broadband stochastic process (wide range of periods), (d) rotational modulation, and (e) random observational errors, independent of (a)-(d). Correlation and power spectrum analyses elucidate periodic and aperiodic variation of these parameters. Time-frequency analysis illuminates periodic and quasi-periodic signals, details of frequency modulation due to differential rotation, and in particular elucidates the rather complex harmonic structure (a) and (b) at timescales in the range {approx}0.1-10 yr. These results using only full-disk data suggest that similar analyses will be useful for detecting and characterizing differential rotation in stars from stellar light curves such as those being produced by NASA's Kepler observatory. Component (c) consists of variations over a range of timescales, in the manner of a 1/f random process with a power-law slope index that varies in a systematic way. A time-dependent Wilson-Bappu effect appears to be present in the solar cycle variations (a), but not in the more rapid variations of the stochastic process (c). Component (d) characterizes differential rotation of the active regions. Component (e) is of course not characteristic of solar variability, but the fact that the observational errors are quite small greatly facilitates the analysis of the other components. The data analyzed in this paper can be found at the National Solar Observatory Web site http://nsosp.nso.edu/cak{sub m}on/, or by file transfer protocol at ftp://ftp.nso.edu/idl/cak.parameters.

  2. Smith Purcell radiation from femtosecond electron bunches

    E-print Network

    Korbly, Stephen E

    2005-01-01

    We present theoretical and experimental results from a Smith-Purcell radiation experiment using the electron beam from a 17 GHz high gradient accelerator. Smith- Purcell radiation occurs when a charged particle travels ...

  3. The genetics of a pharma merger.

    PubMed

    Sanseau, Philippe; Chabot-Fletcher, Marie; Browne, Michael J

    2009-04-01

    The 1990s and early years of this century have seen a series of large-scale mergers and acquisitions in the Pharmaceutical and Biotech arena. These activities each required integration at multiple levels. One of the most important activities is the integration of the R&D pipelines of the participants. We outline the combined portfolio and bioinformatic strategy that was used, and detail the lessons learned for the longer term, from the GlaxoWellcome-SmithKline-Beecham merger in 2000. To date, this has been the largest merger of two equally sized Pharma R&D organisations. PMID:19121408

  4. Plasmepsin Inhibitory Activity and Structure-Guided Optimization of a Potent Hydroxyethylamine-Based Antimalarial Hit

    PubMed Central

    2014-01-01

    Antimalarial hit 1SR (TCMDC-134674) identified in a GlaxoSmithKline cell based screening campaign was evaluated for inhibitory activity against the digestive vacuole plasmepsins (Plm I, II, and IV). It was found to be a potent Plm IV inhibitor with no selectivity over Cathepsin D. A cocrystal structure of 1SR bound to Plm II was solved, providing structural insight for the design of more potent and selective analogues. Structure-guided optimization led to the identification of structurally simplified analogues 17 and 18 as low nanomolar inhibitors of both, plasmepsin Plm IV activity and P. falciparum growth in erythrocytes. PMID:24900843

  5. Susan Krebs-Smith's biography

    Cancer.gov

    Susan Krebs-Smith, PhD, is the Chief of the Risk Factor Monitoring and Methods Branch of the Applied Research Program. In that capacity, she oversees a program of research on the surveillance of risk factors related to cancer, methodological issues to improve the assessment of those factors, and issues related to guidance and food policy.

  6. Curriculum Vitae Douglas E. Smith

    E-print Network

    Smith, Douglas E.

    function · Physics of knot formation TECHNIQUES · Force measuring optical tweezers, manipulation of single6/2014 Curriculum Vitae Douglas E. Smith ADDRESS Department of Physics, University of California, San Diego Natural Science Building, Mail Code 0379, 9500 Gilman Drive, La Jolla, CA 92093 Email: des@physics

  7. Rediscovering Major N. Clark Smith.

    ERIC Educational Resources Information Center

    Buckner, Reginald T.

    1985-01-01

    Historians of American music education have yet to recognize a Black music educator as important and worthy of observation. This article discusses a candidate--Major Nathaniel Clark Smith, a little-known Black music educator, composer of more than a hundred works, businessman, humanitarian, and teacher of numerous big-name jazz musicians. (RM)

  8. Arthur Smith, Local Baptist Pastor.

    ERIC Educational Resources Information Center

    Heaton, Moss, Ed.

    1985-01-01

    Written and published by the students at Gary High School this volume has three articles dealing with East Texas life. The first "Arthur Smith" (David Hancock and others) is an account of growing up in Marian County, Texas is described by the local Baptist minister. The pastor begins with the year of his birth and gives detailed information about…

  9. Evaluation of Additional Y-STR Loci to Resolve Common Haplotypes Amy E. Decker, Margaret C. Kline, and John M. Butler

    E-print Network

    of the Y chromosome using two multiplex PCR assays. Forensic Sci. Int. 139: 107-121. 5) Butler, J.M., Decker, A.E., Kline, M.C., Vallone, P.M. (2005) Chromosomal duplications along the Y-chromosome) Forensic value of fourteen novel STRs on the human Y chromosome. Forensic Sci. Int. 130: 97-111 7) Kayser

  10. M.C. Kline Standards Development for Forensic DNA Testing September 28, 2004 http://www.cstl.nist.gov/biotech/strbase/NISTpub.htm 1

    E-print Network

    identified DNA identification efforts are on-going with over 1,500 victims now identified Applications (Fluorescent markers used today) · DNA Sequencing (Late 1990's) ­ Mitochondrial DNA Restriction Enzyme CutM.C. Kline ­ Standards Development for Forensic DNA Testing September 28, 2004 http

  11. Genetics Home Reference: Smith-Lemli-Opitz syndrome

    MedlinePLUS

    ... PubMed Recent literature OMIM Genetic disorder catalog Conditions > Smith-Lemli-Opitz syndrome On this page: Description Genetic ... names Glossary definitions Reviewed July 2007 What is Smith-Lemli-Opitz syndrome? Smith-Lemli-Opitz syndrome is ...

  12. Smith-Purcell radiation amplifier

    NASA Astrophysics Data System (ADS)

    Oganesyan, Koryun B.

    2015-11-01

    In the framework of the earlier derived dispersion equation, we study induced Smith-Purcell (SP) radiation of relativistic electron beam in the absence of a resonator. We offer a new method for calculation of coefficients for partial amplitudes in the case of rectangular grating. Using this method, as an important example of applications of our earlier derived results (Klochkov D N, Artemyev A I, Oganesyan K B, Rostovtsev Y V and Hu C K 2010 J. Mod. Opt. 57 2060-8), we calculate the growth rate of the SPFEL with a rectangular grating. The growth rate dependences on harmonic number, observation angle and relativistic factor are presented.

  13. Bringing Sally Smith's Vision to Manayunk

    ERIC Educational Resources Information Center

    Ford, Jackie

    2010-01-01

    In this article, the author narrates her application of what she learned from her internship at Sally Smith's Lab School of Washington to her new school and shares the favorable impact it had brought on her teaching career. The author shares her first exposure to the powerful effects of Smith's "Live It, Learn It" methodology as she encountered a…

  14. The Treatment of Smith's Invisible Hand

    ERIC Educational Resources Information Center

    Wight, Jonathan B.

    2007-01-01

    Adam Smith used the metaphor of an invisible hand to represent the instincts of human nature that direct behavior. Moderated by self-control and guided by proper institutional incentives, actions grounded in instincts can be shown to generate a beneficial social order even if not intended. Smith's concept, however, has been diluted and distorted…

  15. A unique tribute to Theobald Smith, 1915.

    PubMed

    Chernin, E

    1987-01-01

    From 1895 to 1915 Theobald Smith served as Professor of Comparative Pathology in the Harvard Medical School in Boston and concurrently as Director of the Massachusetts State Antitoxin and Vaccine Laboratory. On the verge of his departure for a new post at the Rockefeller Institute in Princeton, New Jersey, Smith's colleagues sponsored an elaborate dinner in his honor. Marshall Fabyan, who was the moving spirit behind the affair, also designed an eight-inch by ten-inch souvenir card on which twenty-six sketches depicted Smith's signal researches. This previously unpublished card is reproduced in the present paper, and a digest of the work represented by each sketch is provided. Collectively these summaries are evidence of the remarkable range of Smith's accomplishments, and they serve as a remainder of why Smith is universally regarded as the premier American microbiologist of his day. PMID:3299641

  16. Environmental assessment: Deaf Smith County site, Texas

    SciTech Connect

    Not Available

    1986-05-01

    In February 1983, the US Department of Energy (DOE) identified a location in Deaf Smith County, Texas, as one of nine potentially acceptable sites for a mined geologic repository for spent nuclear fuel and high-level radioactive waste. To determine their suitability, the Deaf Smith County site and the eight other potentially sites have been evaluated in accordance with the DOE's General Guidelines for the Recommendation of Sites for the Nuclear Waste Repositories. The Deaf Smith County site is in the Permian Basin, which is one of five distinct geohydrologic settings considered for the first repository. On the basis of the evaluations reported in this EA, the DOE has found that the Deaf Smith County site is not disqualified under the guidelines. On the basis of these findings, the DOE is nominating the Deaf Smith County site as one of the five sites suitable for characterization. 591 refs., 147 figs., 173 tabs.

  17. Near-coincident K-line and K-edge energies as ionization diagnostics for some high atomic number plasmas

    SciTech Connect

    Pereira, N. R.; Weber, B. V.; Phipps, D. G.; Schumer, J. W.; Seely, J. F.; Carroll, J. J.; Vanhoy, J. R.; Slabkowska, K.; Polasik, M.

    2012-10-15

    For some high atomic number atoms, the energy of the K-edge is tens of eVs higher than the K-line energy of another atom, so that a few eV increase in the line's energy results in a decreasing transmission of the x-ray through a filter of the matching material. The transmission of cold iridium's Asymptotically-Equal-To 63.287 keV K{alpha}{sub 2} line through a lutetium filter is 7% lower when emitted by ionized iridium, consistent with an energy increase of {Delta}{epsilon} Asymptotically-Equal-To 10{+-}1 eV associated with the ionization. Likewise, the transmission of the K{beta}{sub 1} line of ytterbium through a near-coincident K-edge filter changes depending on plasma parameters that should affect the ionization. Systematic exploration of filter-line pairs like these could become a unique tool for diagnostics of suitable high energy density plasmas.

  18. Environmental assessment, Deaf Smith County site, Texas

    SciTech Connect

    Not Available

    1986-05-01

    The Nuclear Waste Policy Act of 1982 (42 USC sections 10101-10226) requires the environmental assessment of a proposed site to include a statement of the basis for nominating a site as suitable for characterization. Volume 2 provides a detailed statement evaluating the site suitability of the Deaf Smith County Site under DOE siting guidelines, as well as a comparison of the Deaf Smith County Site to the other sites under consideration. The evaluation of the Deaf Smith County Site is based on the impacts associated with the reference repository design, but the evaluation will not change if based on the Mission Plan repository concept. The second part of this document compares the Deaf Smith County Site to Davis Canyon, Hanford, Richton Dome and Yucca Mountain. This comparison is required under DOE guidelines and is not intended to directly support subsequent recommendation of three sites for characterization as candidate sites. 259 refs., 29 figs., 66 refs. (MHB)

  19. Environmental assessment: Deaf Smith County site, Texas

    SciTech Connect

    Not Available

    1986-05-01

    In February 1983, the US Department of Energy (DOE) identified a location in Deaf Smith County, Texas, as one of the nine potentially acceptable sites for mined geologic repository for spent nuclear fuel and high-level radioactive waste. To determine their suitability, the Deaf Smith County site and eight other potentially acceptable sites have been evaluated in accordance with the DOE's General Guidelines for the Recommendation of Sites for the Nuclear Waste Repositories. The Deaf Smith County site is in the Permian Basin, which is one of five distinct geohydrologic settings considered for the first repository. On the basis of the evaluations reported in this EA, the DOE has found that the Deaf Smith County site is not disqualified under the guidelines.

  20. Smith-Lemli-Opitz Syndrome

    PubMed Central

    DeBarber, Andrea E.; Eroglu, Yasemen; Merkens, Louise S.; Pappu, Anuradha S.; Steiner, Robert D.

    2012-01-01

    Smith-Lemli-Opitz syndrome (SLOS) is a multiple congenital malformation/intellectual disability syndrome, with clinical characteristics encompassing a wide spectrum and great variability. Elucidation of the biochemical and molecular genetic basis for the autosomal recessively inherited SLOS, specifically, understanding SLOS as a cholesterol deficiency syndrome caused by mutations in DHCR7, opened up enormous possibilities for therapeutic intervention. When cholesterol was discovered to be the activator of sonic hedgehog, cholesterol deficiency with inactivation of this developmental patterning gene was thought to be the cause of SLOS malformations, yet this explanation is overly simplistic. Still, despite these important research breakthroughs, there is no proven treatment for SLOS. Better animal models are needed to allow potential treatment testing and the study of disease pathophysiology, which is incompletely understood. Creation of human cellular models will surely be useful, especially models of brain cells. In vivo human studies are essential as well. There have only been limited natural history studies of SLOS to date. Biomarker development will be critical in facilitating clinical trials in this rare condition, since clinical phenotype may change over many years. Additional research in these and other areas is critical if we are to make headway towards ameloriating the effects of this devastating condition. PMID:21777499

  1. The Devil in Mr. Smith: A Conversation with Jonathan Z. Smith

    ERIC Educational Resources Information Center

    Smith, Jonathan Z.; Pearson, Thomas; Gallagher, Eugene V.; Jensen, Tim; Fujiwara, Satoko

    2014-01-01

    This interview was recorded in November 2012 in Jonathan Z. Smith's Hyde Park graystone. Professor Smith offers insights into how he thinks about his classroom teaching and his students' learning through descriptions of various assignments and classroom activities he has developed over more than forty years of teaching. The discussion…

  2. SMITH FARM FROM CEMETERY HILL, LOOKING SOUTHWEST. (This image shows ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    SMITH FARM FROM CEMETERY HILL, LOOKING SOUTHWEST. (This image shows the Smith Farm in the center of Ebey?s Prairie. Ebey?s Landing and the Puget Sound can be seen on the right. Farmers from the Sherman-Bishop Dairy are visible at the bottom left, cutting hay.) - Smith Farm, 399 Ebey Road, Coupeville, Island County, WA

  3. Another Perspective: An Interview with David Smith

    ERIC Educational Resources Information Center

    Bowman, Ruth A.; Johnson, Kelli

    2005-01-01

    To provide another perspective on evaluation within nonformal settings, "New Directions for Evaluation" recently interviewed David Smith, the coordinator of the Professional Learning to Close the Achievement Gap program for the Kansas City, Kansas, Public Schools, who has extensive background in education and educational research. He formerly held…

  4. Dialogues with Marilyn Cochran-Smith

    ERIC Educational Resources Information Center

    Fiorentini, Dario; Crecci, Vanessa Moreira

    2015-01-01

    For more than 30 years, Dr. Marilyn Cochran-Smith has developed and directed research and contributed to publications about education and "practitioner research," especially about teachers' research and learning in inquiry communities. Her primary topics are inquiry communities, teacher research, teacher education for social…

  5. Immunological Memory is Associative Derek J. Smith

    E-print Network

    Somayaji, Anil

    Immunological Memory is Associative Derek J. Smith Department of Computer Science University of New Laboratory Los Alamos, NM 87545, USA asp@t10.lanl.gov Abstract This paper argues that immunological memory population in the immune system). Keywords: Immunological Memory, Associative Memory, Cross-Reactive Memory

  6. Circuit reconstruction tools today Stephen J Smith

    E-print Network

    Born, Richard

    Circuit reconstruction tools today Stephen J Smith To understand how a brain processes information, we must understand the structure of its neural circuits--especially circuit interconnection topologies and the cell and synapse molecular architectures that determine circuit-signaling dynamics. Our

  7. Geography 1: UCLA, Prof. Smith Name:__________________ Section:_________________

    E-print Network

    greater than absolute zero (0°K = -273°C = - 495°F). Radiant energy moves in electromagnetic wavesGeography 1: UCLA, Prof. Smith Name:__________________ Section:_________________ Exercise 2: ENERGY BUDGET AND TEMPERATURE Part I. Energy Budget Radiation is energy emitted by all bodies with a temperature

  8. Disappearing Arctic Lakes L. C. Smith,1

    E-print Network

    Disappearing Arctic Lakes L. C. Smith,1 * Y. Sheng,2 G. M. MacDonald,1 L. D. Hinzman3 Arctic warming has accelerated since the 1980s, driving an array of complex physical and ecological changes (2), which plays an integral role in nearly every aspect of the Arctic system. We compared satellite

  9. History of Mathematics Instructor: Sam Smith

    E-print Network

    Smith, Sam

    MED 4015 History of Mathematics Syllabus Fall 2009 Instructor: Sam Smith Office: Barbelin 212. Text: Victor Katz, A History of Mathematics: An Introduction, Harper Collins Course Description: This course will be a seminar on the history of mathematics. We will proceed chronologically from the first

  10. S.W. Smith. "Hardware Security Modules."

    E-print Network

    Smith, Sean W.

    S.W. Smith. "Hardware Security Modules." in B. Rosenberg (editor). Handbook of Financial Cryptography and Security. Chapman and Hall/CRC. 2010. 257--278. DRAFT. #12;Chapter 1 Hardware Security Modules with specialized Hardware Security Modules (HSM) is a common practice in financial cryptography, which probably con

  11. Examination of Additional Y-STR Loci for Increased Resolution of Common Haplotypes Amy E. Decker, Peter M. Vallone, Margaret C. Kline, Janette W. Redman, and John M. Butler

    E-print Network

    ) Butler, J.M., Decker, A.E., Kline, M.C., Vallone, P.M. (2005) Chromosomal duplications along the Y-chromosome regions of the Y chromosome using two multiplex PCR assays. Forensic Sci. Int. 139: 107-121. 4) Redd, A.J., et al. (2002) Forensic value of fourteen novel STRs on the human Y chromosome. Forensic Sci. Int. 130

  12. Effects of Storage Temperature on the Recovery of DNA from Aged-Bloodstains Margaret C. Kline, Janette W. Redman, David L. Duewer, Barbara J. Porter* and John M. Butler

    E-print Network

    Effects of Storage Temperature on the Recovery of DNA from Aged-Bloodstains Margaret C. Kline the optimum conditions to successfully recover DNA information. Artificial aging of samples may not be equivalent to natural aging. Therefore, it is desirable to evaluate proposed sample and storage conditions

  13. The Smith-Lemli-Opitz syndrome

    PubMed Central

    Kelley, R.; Hennekam, R.

    2000-01-01

    The Smith-Lemli-Opitz syndrome (SLOS) is one of the archetypical multiple congenital malformation syndromes. The recent discovery of the biochemical cause of SLOS and the subsequent redefinition of SLOS as an inborn error of cholesterol metabolism have led to important new treatment possibilities for affected patients. Moreover, the recent recognition of the important role of cholesterol in vertebrate embryogenesis, especially with regard to the hedgehog embryonic signalling pathway and its effects on the expression of homeobox genes, has provided an explanation for the abnormal morphogenesis in the syndrome. The well known role of cholesterol in the formation of steroid hormones has also provided a possible explanation for the abnormal behavioural characteristics of SLOS.???Keywords: Smith-Lemli-Opitz syndrome; cholesterol metabolism; 7-dehydrocholesterol reductase; clinical history; management PMID:10807690

  14. Malus domestica cv. Granny Smith (Cultivated) 

    E-print Network

    James R. Manhart

    2011-08-10

    from that of Golden Delicious in being less tart yet acceptable and eye ap peal is good. Granny Smith is a standard variety with round green fruit. Flavor appears to be outstand ing. Observational Varieties This list includes varieties....1294 Extension Service? The Texas A&M University System? Daniel C. Pfannstiei. Director? College Station, Texas texas apples B1294 CONTENTS Soi I. . . . . . . . . . . . . . . . . . . . . . . .. 3 Orchard Establ ishment. . . . .. 3 Varieties...

  15. Smith Newton Vehicle Performance Evaluation (Brochure)

    SciTech Connect

    Not Available

    2012-08-01

    The Fleet Test and Evaluation Team at the U.S. Department of Energy's National Renewable Energy Laboratory is evaluating and documenting the performance of electric and plug-in hybrid electric drive systems in medium-duty trucks across the nation. Through this project, Smith Electric Vehicles will build and deploy 500 all-electric medium-duty trucks. The trucks will be deployed in diverse climates across the country.

  16. Brian Sutton-Smith (1924-2015).

    PubMed

    Meckley, Alice M

    2015-12-01

    Brian Sutton-Smith, renowned scholar of play across multiple disciplines, including psychology, died on March 7, 2015, from complications of Alzheimer's disease. He was 90 years old. For over half a century, Brian Sutton-Smith has been the foremost scholar of play, authoring over 50 books and 350 articles. Sutton-Smith's legacy includes not only his numerous influential works but also his profound impact on scholars of play. He advocated an interdisciplinary approach as essential to play research. His noteworthy scholarship established a focus on play as a serious subject of investigation, a focus on real children and their activities over child developmental norms, and a focus on the adaptive variability of play over play's variables. As a psychology professor at Teachers College, Columbia University (1967-1977), Brian entered the most prolific period of his life. Brian's professorship and role as head of the Graduate Program in Human Development at the University of Pennsylvania (1977-1994) confirmed his interdisciplinary approach as he taught and mentored graduate students in psychology, education, and folklore. (PsycINFO Database Record PMID:26653322

  17. Chili Cookoff: Unique Ingredients Prove Successful in Ross Smith’s Big Pot of Chili | Poster

    Cancer.gov

    By Ashley DeVine, Staff Writer If the past is any indication, judges at the Protective Services Chili Cookoff give high marks for chili recipes containing unique or uncommon ingredients. Previous winning recipes have included ingredients such as black beans, pumpkin, pineapple, pork loin, and even bourbon. Judges at the 12th annual event, held Jan. 5, continued this tradition by voting for Ross Smith’s Big Pot of Chili, which featured three types of meat, four different sauces, baker’s chocolate, and parmesan rind.  

  18. Breeding productivity of Smith Island black ducks

    USGS Publications Warehouse

    Haramis, G.M.; Jorde, D.G.; Olsen, G.H.; Stotts, D.B.; Harrison, M.K.

    2002-01-01

    We investigated the breeding performance of American black ducks (Anas rubripes) on Smith Island, Chesapeake Bay, to improve our understanding of island black duck breeding ecology and to make management recommendations to enhance productivity. During 1995-96, we implanted 56 female black ducks with 20-g radio transmitters and tracked 35 of the individuals through the breeding season to locate nests, determine nest fate, and identify brood habitat. We also increased preseason banding efforts and compared capture characteristics over 12 years with those from the Deal Island Wildlife Management Area, a banding site on the mainland of Tangier Sound. A low rate of nesting (37%), lack of renesting, and poor hatching success (31%) indicated that island salt marsh habitats present a harsh environment for breeding black ducks. Black ducks located 11 of 13 nests (85%) in black needlerush (Juncus roemerianus) marsh where they were vulnerable to flooding from extreme tides and to egg predators. No nests were found on forested tree hammocks, a feature that distinguishes Smith Island from nearby South Marsh and Bloodsworth Islands. Nest predators included red foxes (Vulpes vulpes), herring gulls (Larus argentams), fish crows (Corvus ossifragus), and, potentially, Norway rats (Rattus norvegicus). Unlike mainland red foxes, foxes radio tracked on Smith Island were found to be capable swimmers and effective low marsh predators. We found shoreline meadows of widgeon grass (Ruppia maritima) to be important foraging sites for black ducks and suspected that the virtual absence of fresh water in this high salinity environment (1217+ ppt) to incur some cost in terms of growth and survival of ducklings. Preseason bandings revealed a high proportion of banded adults and a strong positive correlation in age ratios with the Deal Island banding site. This latter finding strongly suggests a negative universal effect of storm tides on nest success for Tangier Sound black ducks. Management to reduce nest predators, especially gulls and foxes, likely will have the greatest immediate benefit for island breeding black ducks.

  19. Publications for Evelyn Smith Smith, E. (2015). Caloric restriction reduces binge eating: a

    E-print Network

    Müller, Dietmar

    2015-01-01

    : a systematic review (forthcoming). International Journal of Eating Disorders, In Press. Smith, E., Hay, P Remediation Therapy (CRT) for Eating and Weight Disorders, (pp. 176-191). Hove, East Sussex: Routledge of psychological constructs including disordered eating, mood, emotional regulation, habitual cluster behaviours

  20. The Robert H. Smith Faculty of Agriculture, Food & Environment International School of Agricultural Sciences

    E-print Network

    Nathan, Ran

    The Robert H. Smith Faculty of Agriculture, Food & Environment International School of Agricultural Sciences Application Guidelines International MSc Programs July 2015 #12;The Robert H. Smith Faculty...............................................................................................................6 International School Postal Address: The Robert H. Smith Faculty of Agriculture, Food

  1. 78 FR 32250 - CDM Smith and Dynamac Corp; Transfer of Data

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-29

    ...be transferred to CDM Smith and its subcontractor, Dynamac Corp, in accordance with...308(i)(2). CDM Smith and its subcontractor, Dynamac Corp, have been awarded...information will enable CDM Smith and its subcontractor, Dynamac Corp, to fulfill the...

  2. 78 FR 23845 - Drawbridge Operation Regulations; Narrow Bay, Smith Point, NY

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-23

    ...a public event, the Smith Point Triathlon. Under this temporary deviation the Smith Point Bridge, mile 6.1, across Narrow Bay between Smith Point and Fire Island, will remain...schedule immediately at the end of the designated time...

  3. Smith Newton Vehicle Performance Evaluation - Cumulative (Brochure)

    SciTech Connect

    Not Available

    2014-08-01

    The Fleet Test and Evaluation Team at the U.S. Department of Energy's National Renewable Energy Laboratory is evaluating and documenting the performance of electric and plug-in hybrid electric drive systems in medium-duty trucks across the nation. U.S. companies participating in this evaluation project received funding from the American Recovery and Reinvestment Act to cover part of the cost of purchasing these vehicles. Through this project, Smith Electric Vehicles is building and deploying 500 all-electric medium-duty trucks that will be deployed by a variety of companies in diverse climates across the country.

  4. Mepolizumab: First Global Approval.

    PubMed

    Keating, Gillian M

    2015-12-01

    Mepolizumab (Nucala(®)) is a fully humanized monoclonal antibody against interleukin-5 (IL-5) that is being developed by GlaxoSmithKline. Subcutaneous mepolizumab is approved in the USA for the add-on maintenance treatment of patients aged ?12 years with severe asthma and an eosinophilic phenotype, and is awaiting approval in the EU. Mepolizumab blocks IL-5 and reduces blood and sputum eosinophil counts in patients with asthma. In the phase III MENSA trial in patients with recurrent asthma exacerbations and evidence of eosinophilic inflammation despite high-dose inhaled glucocorticoid therapy, mepolizumab significantly reduced the annualized exacerbation rate. In the phase III SIRIUS trial, mepolizumab had an oral glucocorticoid-sparing effect in patients with severe eosinophilic asthma requiring systemic glucocorticoid maintenance therapy. This article summarizes the milestones in the development of mepolizumab leading to this first approval for severe asthma with an eosinophilic phenotype. PMID:26603873

  5. AACR-NCI-EORTC--21st International Symposium. Molecular targets and cancer therapeutics--Part 2.

    PubMed

    Walker, Karen; Padhiar, Meenal

    2010-01-01

    The 21st international symposium of the American Association for Cancer Research (AACR), the NCI and the European Organization for Research and Treatment of Cancer (EORTC), held in Boston, included topics covering the development of therapeutics and molecular targets in the field of cancer research. This conference report highlights selected presentations on the development of novel drugs for cancer. Investigational drugs discussed include RO-506876 (F Hoffmann-La Roche Ltd), GDC-0980 (Genentech Inc), EMD-1214063 and EMD-1204831 (Merck Serono SA), AR-mTOR01 and AR-mTOR-26 (Array BioPharma Inc), GSK-2126458 (GlaxoSmithKline plc), EXEL-1415 and EXEL-2008 (Exelixis Inc), FP-1039 (FivePrime Therapeutics Inc), and AV-412 (AVEO Pharmaceuticals Inc). PMID:20024839

  6. Antibody engineering and therapeutics conference

    PubMed Central

    Larrick, James W; Parren, Paul WHI; Huston, James S; Plückthun, Andreas; Bradbury, Andrew; Tomlinson, Ian M; Chester, Kerry A; Burton, Dennis R; Adams, Gregory P; Weiner, Louis M; Scott, Jamie K; Alfenito, Mark R; Veldman, Trudi; Reichert, Janice M

    2014-01-01

    The 25th anniversary of the Antibody Engineering & Therapeutics Conference, the Annual Meeting of The Antibody Society, will be held in Huntington Beach, CA, December 7–11, 2014. Organized by IBC Life Sciences, the event will celebrate past successes, educate participants on current activities and offer a vision of future progress in the field. Keynote addresses will be given by academic and industry experts Douglas Lauffenburger (Massachusetts Institute of Technology), Ira Pastan (National Cancer Institute), James Wells (University of California, San Francisco), Ian Tomlinson (GlaxoSmithKline) and Anthony Rees (Rees Consulting AB and Emeritus Professor, University of Bath). These speakers will provide updates of their work, placed in the context of the substantial growth of the industry over the past 25 years. PMID:25517297

  7. Use of MenACWY-CRM in adolescents in the United States.

    PubMed

    Black, Steven; Block, Stan L

    2013-03-01

    Adolescents constitute a high-risk group for invasive meningococcal disease. MenACWY-CRM (Menveo, Novartis Vaccines, Cambridge, MA) is a quadrivalent meningococcal conjugate vaccine indicated to prevent invasive meningococcal disease caused by Neisseria meningitidis serogroups A, C, W-135, and Y. It has been approved for use in persons age 2-55 years. The tolerability and immunogenicity of MenACWY-CRM in adolescents have been ascertained in phase 2 and 3 trials against MPSV4 (Menomune, sanofi pasteur, Swiftwater, PA), an unconjugated quadrivalent meningococcal vaccine, and MenACWY-D (Menactra, sanofi pasteur), another conjugated quadrivalent meningococcal vaccine. Clinical trials also have demonstrated that MenACWY-CRM is well tolerated and immunogenic when administered to adolescents concomitantly with the combined tetanus, diphtheria, and acellular pertussis vaccine (Boostrix, GlaxoSmithKline Biologicals, Rixensart, Belgium) and the quadrivalent human papillomavirus vaccine (Gardasil, Merck & Co., Inc., Whitehouse Station, NJ). PMID:23299001

  8. Vaccines for the prevention of human papillomavirus infections.

    PubMed

    Speck, L M; Tyring, S K

    2006-01-01

    Human papillomavirus (HPV) infection is the known cause of almost all cases of cervical cancer. An understanding of the HPV genome has allowed the development of two prophylactic vaccines capable of protecting against both persistent HPV infection and cervical intraepithelial neoplasia (CIN) with 100% efficacy in fully vaccinated women. The vaccines, manufactured by Merck (Gardasil, which was approved by the US FDA in June, 2006) and GlaxoSmithKline (Cervarix, which will be submitted for US FDA approval by the end of 2006), both target HPV types 16 and 18, which together account for 70% of cervical cancer. Merck vaccine also targets HPV 6 and 11, covering =90% of genital warts. These vaccines are highly immunogenic and have an excellent safety profile. HPV vaccines promise to offer an exciting contribution to healthcare and cancer prevention. However, many questions remain concerning who to vaccinate, the duration of protection, cost, public acceptance, and the potential for worldwide distribution. PMID:16912836

  9. Vaccines against human papilloma virus and cervical cancer: an overview.

    PubMed

    Sharma, Savita

    2008-07-01

    The paradigm of preventing human papilloma virus (HPV) infection through currently approved vaccines, namely, Gardasil, manufactured by Merck and Co., Inc. (Whitehouse Station, NJ) and Cervarix, manufactured by GlaxoSmithKline (GSK, Philadelphia) holds tremendous promise for the developing countries in decreasing the burden of HPV infection and its sequelae, such as cervical cancer, genital warts and anogenital cancers. Effective screening programs that have reduced the burden of this killer disease in the developed countries are still lacking in India, despite the high incidence of cervical cancer and the implementation of the National Cancer Control Programme since 1975. The recent breakthrough in the global war against cervical cancer will provide new insight for meeting the future challenge of the prevention of cervical cancer in India. PMID:19876472

  10. [Development of an HPV vaccine--remaining issues and perspective].

    PubMed

    Kondo, Kazunari

    2009-01-01

    Cervical cancer, the second most frequent gynecological malignancy in the world, is caused by infection with one of the 15 types of high-risk HPVs. Vaccines protecting women from infection with high-risk HPVs can reduce prevalence of cervical cancer. At present, two prophylactic vaccines (GlaxoSmithKline "Cervarix" and Merck "Gardasil") have been approved by several countries. These vaccines can almost completely protect HPV16 and 18 infections which account for approximately 50% and 20% of cervical cancer, respectively. However, cervical cancer screening should continue in all vaccinated women due to exposure of the other oncogenic HPV types. There are also unanswered remaining questions about overall vaccine effectiveness, duration of protection, and adverse effect. PMID:19177753

  11. Human papillomavirus vaccine update.

    PubMed

    Ames, Alisa; Gravitt, Patti

    2007-03-01

    With the approval of Gardasil (Merck and Co., Inc., Whitehouse Station, NJ) in June of 2006 and the pending approval of Cervarix (GlaxoSmithKline, London, UK), two prophylactic human papillomavirus (HPV) vaccines will be available for clinical use. Randomized controlled trials have shown that both vaccines are safe and highly effective in preventing persistent infection and lesions caused by HPV 16 and 18--the types responsible for 70% of cervical cancers worldwide. Determining an effective vaccination strategy is now the most pressing issue facing clinicians, parents, public health officials, and policy makers. We discuss the appropriate age of vaccination, vaccine acceptance, implementation strategies in low resource settings, and the future of screening. PMID:17324353

  12. Human papillomavirus vaccine trials and tribulations: Vaccine efficacy.

    PubMed

    Handler, Nancy S; Handler, Marc Z; Majewski, Slawomir; Schwartz, Robert A

    2015-11-01

    As of December 2014, there were 3 approved vaccines for human papillomavirus (HPV): bivalent Cervarix (GlaxoSmithKline, New York, NY), quadrivalent Gardasil (Merck and Co, Kenilworth, NJ), and 9-valent Gardasil-9 (Merck and Co). The average cost per dose is $120, with a recommended 3-dose course. The quadrivalent vaccine is the most widely administered worldwide. As with the bivalent and 9-valent vaccines, the vaccine is considered safe, although concerns have been raised. In addition to immunization against the targeted HPV types, there is evidence that there is cross protection against other types of HPV. This continuing medical education review evaluates the differences in vaccines that are currently on the market; part II focuses on the cost-effectiveness of vaccination, the HPV vaccination programs currently instituted around the globe, efficacy, and safety. PMID:26475535

  13. FDA licensure of bivalent human papillomavirus vaccine (HPV2, Cervarix) for use in females and updated HPV vaccination recommendations from the Advisory Committee on Immunization Practices (ACIP).

    PubMed

    2010-05-28

    On October 16, 2009, the Food and Drug Administration (FDA) licensed bivalent human papillomavirus vaccine (HPV2; Cervarix, GlaxoSmithKline) for use in females aged 10 through 25 years. Cervarix is the second human papillomavirus (HPV) vaccine licensed for use in females in the United States. Quadrivalent HPV vaccine (HPV4; Gardasil, Merck & Co, Inc.) was licensed in 2006 for use in females aged 9 through 26 years, and the Advisory Committee on Immunization Practices (ACIP) recommended routine HPV4 vaccination of females aged 11 or 12 years, and catch-up vaccination for females aged 13 through 26 years. This report provides updated recommendations for routine and catch-up vaccination of females with either HPV2 or HPV4. PMID:20508593

  14. Hemozoin and antimalarial drug discovery.

    PubMed

    Fong, Kim Y; Wright, David W

    2013-08-01

    Recent initiatives to develop more effective and affordable drugs, controlling mosquitoes and development of a preventative vaccine have been launched with the goal of completely eradicating malaria. To this end, Novartis (Surrey, UK) and GlaxoSmithKline (Middlesex, UK) screened their chemical libraries of approximately two million small molecules for antimalarial properties, which resulted in a set of over 20,000 'highly druggable' initial hits. Efforts in academia are centered on specific pathway targets. One such high-throughput screening effort has been focused on hemozoin formation, a unique heme detoxification pathway found in the malaria parasite. This review discusses the current approaches and limitations of high-throughput screening discovery of hemozoin inhibitors. In the future, new methods must be developed to validate the mechanism of action of these hit compounds within the parasite. PMID:23919553

  15. Father Knows Best: Using Adam Smith to Teach Transactions Costs

    ERIC Educational Resources Information Center

    Dupont, Brandon

    2014-01-01

    Adam Smith's moral philosophy can be used to introduce economics students to the important idea of transactions costs. The author provides a brief background in this article to Smith's moral philosophy and connects it to the costs of transacting in a way that fits easily into the standard principles of microeconomics classroom. By doing…

  16. Oscar F. Smith Middle School: One Extra Degree

    ERIC Educational Resources Information Center

    Principal Leadership, 2012

    2012-01-01

    This article features Oscar F. Smith Middle School, a challenging school in Chesapeake, Virginia. When Principal Linda Scott exclaims, "Oscar F. Smith Middle School is "hot"!" to visitors, she is not referring to the inside temperature of the bustling school of grades 6-8 located in the historic South Norfolk borough of Chesapeake. She is…

  17. 1. VIEW OF THE SMITH NO. 3 SITE AREA TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. VIEW OF THE SMITH NO. 3 SITE AREA TO THE NORTHWEST. THE MINE OFFICE BUILDING IS IN THE FOREGROUND AND THE TIPPLE AND PROCESSING PLANT ARE IN THE BACKGROUND. - Smith Mine, Bear Creek 1.5 miles West of Town of Bear Creek, Red Lodge, Carbon County, MT

  18. inside-out: speculating on the interior Cathy Smith

    E-print Network

    Boyd, Colin

    to critique my personal experience of design practice in interior sites. I have drawn from writings aboutinside-out: speculating on the interior Cathy Smith Queensland University of Technology IDEA Journal 2004 Copyright 2004 Cathy D. Smith Abstract: In this paper, I have speculated on the interior

  19. College of Agricultural Sciences Calvin & Merle Smith Wheat Research

    E-print Network

    Grünwald, Niklaus J.

    College of Agricultural Sciences Calvin & Merle Smith Wheat Research Endowment Fund Application PURPOSE The Calvin & Merle Smith Wheat Research Endowment Fund supports a student's work on an OSU wheat of Agricultural Sciences and related fields who are working on OSU wheat research projects. Funds may be used

  20. The Clarice Smith Performing Arts Center 2015-2016 Season

    E-print Network

    Hill, Wendell T.

    The Clarice Smith Performing Arts Center 2015-2016 Season Updated on June 2, 2015. All information is subject to change. Visit https://theclarice.umd.edu/seasons/2015-2016 for updated information and to join Clarice Smith Performing Arts Center 2015-2016 Season Updated on June 2, 2015. All information is subject

  1. (Mis)Representing Underachievement: A Rejoinder to Gorard and Smith

    ERIC Educational Resources Information Center

    Connolly, Paul

    2008-01-01

    This article provides a brief rejoinder to Gorard and Smith's reply to an article I published in a previous issue of British Journal of Sociology of Education. In that original article I provided a critical review of their quantitative research on gender and education in the United Kingdom. In their reply to this article, Gorard and Smith seem to…

  2. Gilbert M. Smith, master boatbuilder of Long Island, New York 

    E-print Network

    Merwin, Daria Elizabeth

    2000-01-01

    to several variants of small work and pleasure craft. This thesis is an examination of Long Island boatbuilding via a study of the career of the most prolific and best known local boatbuilder, Gilbert Monroe Smith (1843-1940). It is estimated that Gil Smith...

  3. Author! Author! The Gallant Children's Author: Dick King-Smith

    ERIC Educational Resources Information Center

    Brodie, Carolyn S.

    2005-01-01

    This column presents a brief biography of Dick King-Smith. Born on March 27, 1922 and raised in Gloucestershire, England, he grew up with animals of all kinds. King-Smith was a farmer for twenty years and then became a school teacher. He was also a soldier during wartime, a traveling salesman, shoe factory worker, and television presenter. He…

  4. H.O. SMITH BOTANIC GARDENS Welcome through Childhood's Gate,

    E-print Network

    H.O. SMITH BOTANIC GARDENS Welcome through Childhood's Gate, the children's garden in the H.O Smith Botanic Gardens. This is your garden--a place of transformation, discovery, and learning. Experience generation. In addition to the Arboretum rules, in the children's garden we ask that visitors please

  5. EIGENVALUES AND THE SMITH NORMAL FORM Joseph J. Rushanan

    E-print Network

    Rushanan, Joe J.

    , MA 01730 Abstract. Results are shown that compare the Smith Normal Form (SNF) over the integers on the size of the largest element of the SNF when the matrix is diagonalizable with nonzero integer and its Smith Normal Form (SNF) over the integers. Our goals are more general than those results

  6. SOUTHERN UTAH UNIVERSITY SHARWAN SMITH STUDENT CENTER POLICY

    E-print Network

    Freden, Eric

    1 SOUTHERN UTAH UNIVERSITY SHARWAN SMITH STUDENT CENTER POLICY SECTION: Building Use POLICY #: 100-State Holiday), Labor Day, Fall Break, Thanksgiving Day, and Christmas Day. During semester breaks the SSSC in the University Catalog. . #12;2 SOUTHERN UTAH UNIVERSITY SHARWAN SMITH STUDENT CENTER POLICY SECTION: Building

  7. Serological response following re-vaccination with Salmonella typhi Vi-capsular polysaccharide vaccines in healthy adult travellers.

    PubMed

    Roggelin, Louise; Vinnemeier, Christof D; Fischer-Herr, Johanna; Johnson-Weaver, Brandi T; Rolling, Thierry; Burchard, Gerd D; Staats, Herman F; Cramer, Jakob P

    2015-08-01

    An injectable Vi-capsular polysaccharide vaccine against typhoid fever is available but vaccine-induced immunity tends to wane over time. The phenomenon of immunotolerance or hyporesponsiveness has earlier been described for polysaccharide vaccines such as pneumococcal capsular polysaccharide vaccine and some publications also suggest a possible immunotolerance after revaccination with Vi-capsular polysaccharide vaccines. In this study, post-immunisation antibody concentrations in adult travellers first vaccinated with a Salmonella typhi Vi-capsular polysaccharide vaccine (primary vaccination group) were compared with those having received one or more vaccinations previously (multiple vaccinations group). Vaccines administered were Typherix(®) (GlaxoSmithKline), Typhim Vi(®) (Sanofi Pasteur MSD) or Hepatyrix(®) (GlaxoSmithKline). Blood samples were obtained prior to vaccination (day 0) and on day 28 (-1/+14) after vaccination. Serum Vi-Antigen IgG concentrations were measured by ELISA. Of the 85 subjects included in the per protocol data set, 45 (53%) belonged to the multiple vaccinations group. In both groups, geometric mean antibody concentrations (GMCs) were significantly higher after vaccination than before vaccination. Pre-vaccination GMCs were lower in the primary vaccination group than in the multiple vaccinations group (3.40 ?g/ml versus 6.13 ?g/ml, P=0.005), while there was no significant difference in the post vaccination GMCs between groups (11.34 ?g/ml versus 14.58 ?g/ml, P=0.4). In the multiple vaccinations group, vaccination was performed 18 to 57 months after the last vaccination (median 38 months) and there was a negative correlation between time since last vaccination and antibody concentration on day 0. In conclusion, we were not able to demonstrate a relevant immunotolerance after multiple versus primary vaccination with S. typhi Vi-capsular polysaccharide vaccines. PMID:26144902

  8. Processing Semblances Induced through Inter-Postsynaptic Functional LINKs, Presumed Biological Parallels of K-Lines Proposed for Building Artificial Intelligence

    PubMed Central

    Vadakkan, Kunjumon I.

    2011-01-01

    The internal sensation of memory, which is available only to the owner of an individual nervous system, is difficult to analyze for its basic elements of operation. We hypothesize that associative learning induces the formation of functional LINK between the postsynapses. During memory retrieval, the activation of either postsynapse re-activates the functional LINK evoking a semblance of sensory activity arriving at its opposite postsynapse, nature of which defines the basic unit of internal sensation – namely, the semblion. In neuronal networks that undergo continuous oscillatory activity at certain levels of their organization re-activation of functional LINKs is expected to induce semblions, enabling the system to continuously learn, self-organize, and demonstrate instantiation, features that can be utilized for developing artificial intelligence (AI). This paper also explains suitability of the inter-postsynaptic functional LINKs to meet the expectations of Minsky’s K-lines, basic elements of a memory theory generated to develop AI and methods to replicate semblances outside the nervous system. PMID:21845180

  9. Trinucleotide repeat expansion and DRPLA (Smith`s disease): Molecular characterization of atrophin-1

    SciTech Connect

    Margolis, R.L.; Li, S.H.; Li, X.J.; Ross, C.A.

    1994-09-01

    Smith`s disease (also known as dentatorubral pallidoluysian atrophy or DRPLA) is a rare, progressive, fatal neuropsychiatric disorder similar to Huntington`s disease (HD). Smith`s disease is characterized by ataxia, choreoathetosis, myoclonic epilepsy, dementia, and genetic anticipation. Neuropathological findings include prominent cell loss in the dentate nucleus of the cerebellum, the globus pallidus, the red nucleus, and the subthalamic nucleus. An expansion of a CAG trinucleotide repeat encoding polyglutamine in a gene originally identified in our laboratory as part of a program to clone candidate genes for disorders with anticipation has recently been found to cause this disorder. We have identified two families that demonstrate the pathological and genetic features (expanded CAG repeat and anticipation) of this disease. Northern analysis indicates that the gene, which we have termed atrophin-1, is widely expressed as a 5 kb mRNA in normal human brain and peripheral tissues. Brain expression is highest in the cerebellum. The developmental expression of the rat homologues of IT-15 (the gene in which a CAG expansion causes HD) and atrophin-1 were compared. Atrophin-1 was most highly expressed in early rat embryo brain (E16), whereas the greatest expression of IT-15 was in the adult rat brain. Cloning and sequencing of the open reading frame from inserts contained in brain cDNA libraries is in progress. In addition to the CAG repeat, the ORF contains an unusual region of alternating acidic and basic amino acids. Further characterization of atrophin-1, and comparison of it to other genes in which trinucleotide repeat expansion leads to neuropsychiatric disorders, should lead to a better understanding of the pathophysiology by which CAG repeat expansion causes human disease.

  10. Antifungal saponins from Paris polyphylla Smith.

    PubMed

    Deng, Dawei; Lauren, Denis R; Cooney, Janine M; Jensen, Dwayne J; Wurms, Kirstin V; Upritchard, Jenine E; Cannon, Richard D; Wang, Ming Zhong; Li, Ming Zhang

    2008-09-01

    Three steroidal saponins, including one new and two known compounds, were isolated from the rhizomes of Paris polyphylla Smith. One- and two-dimensional NMR, LC-MS, and interpretation of hydrolytic cleavage experiments led to the identification of the structure of the new saponin as ( 25R)-spirost-5-ene-3 beta,17 alpha-diol (pennogenin) 3- O-{ O- alpha- L-rhamnopyranosyl-(1-->2)- O-[ O- beta-xylopyranosyl-(1-->5)- alpha- L-arabinofuranosyl-(1-->4)]- beta- D-glucopyranoside}. The isolated saponins were evaluated for their antifungal activity against Cladosporium cladosporioides and Candida species and showed comparable activity to chemicals used in some commercial products. PMID:18729041

  11. A review of "Andrew Marvell: The Chameleon" by Nigel Smith 

    E-print Network

    Garganigo, Alex

    2012-01-01

    chime with each other, as do authors, subject matters, intertexts, contexts), and Nigel Smith?s new biography chimes in with genial intelligence and erudition. Smith capitalizes on the 2003 edition of Marvell?s prose from Yale (soon to be completed... in the close reading of passages and their intertexts that some varieties of historicism have dismissed as outmoded New Criticism and in?uence study. Marvell may have spoken and spied for others, but he also may have acted as a double agent, especially...

  12. Theobald Smith and animal parasitology: highlights on an anniversary.

    PubMed

    Katz, F F

    1994-12-01

    In marking the 100th anniversary of the landmark publication in 1893 by Theobald Smith and Frederick L. Kilborne on cattle babesiosis and arthropod transmission, this article takes note of other contributions of Theobald Smith to the knowledge of a variety of parasitic organisms. Notable are his studies on the protozoan agent of avian enterohepatitis. The results of Smith's work in comparative pathology, to which he devoted his professional life, have had broad applications with economic and health benefits for domestic animals and humans. PMID:11639530

  13. 76 FR 4648 - PowerSmith Cogeneration Project, LP; Notice of Filing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-26

    ... Energy Regulatory Commission PowerSmith Cogeneration Project, LP; Notice of Filing January 19, 2011. Take notice that on January 13, 2011, PowerSmith Cogeneration Project, LP (PowerSmith), pursuant to section... Regulations for the topping-cycle cogeneration facility owned and operated by PowerSmith located in...

  14. Variable efficacy of repeated annual influenza vaccination Derek J. Smith,

    E-print Network

    New Mexico, University of

    Variable efficacy of repeated annual influenza vaccination Derek J. Smith, ¢¡ Stephanie Forrest-665-3493. Running head: Annual influenza vaccination. Classification: Medical Science Keywords: influenza, vaccination, original antigenic sin, vaccine efficacy, repeated vaccination. 1 #12;ABSTRACT Conclusions have

  15. Intellectual biography of David Smith Cairns (1862-1946) 

    E-print Network

    Finlayson, Marlene Elizabeth

    2015-06-27

    This thesis explores the formative influences, development and impact of the theology of David Smith Cairns, Scottish minister, academic and writer, during the high point of British imperial expansion, and at a time of ...

  16. Chromospheric Variability: Analysis of 36 years of Time Series from the National Solar Observatory/Sacramento Peak Ca II K-line Monitoring Program

    NASA Technical Reports Server (NTRS)

    Scargle, Jeffrey D.; Keil, Stephen L.; Worden, Simon P.

    2014-01-01

    Analysis of more than 36 years of time series of seven parameters measured in the NSO/AFRL/Sac Peak K-line monitoring program elucidates five elucidates five components of the variation: (1) the solar cycle (period approx. 11 years), (2) quasi-periodic variations (periods approx 100 days), (3) a broad band stochastic process (wide range of periods), (4) rotational modulation, and (5) random observational errors. Correlation and power spectrum analyses elucidate periodic and aperiodic variation of the chromospheric parameters. Time-frequency analysis illuminates periodic and quasi periodic signals, details of frequency modulation due to differential rotation, and in particular elucidates the rather complex harmonic structure (1) and (2) at time scales in the range approx 0.1 - 10 years. These results using only full-disk data further suggest that similar analyses will be useful at detecting and characterizing differential rotation in stars from stellar light-curves such as those being produced by NASA's Kepler observatory. Component (3) consists of variations over a range of timescales, in the manner of a 1/f random noise process. A timedependent Wilson-Bappu effect appears to be present in the solar cycle variations (1), but not in the stochastic process (3). Component (4) characterizes differential rotation of the active regions, and (5) is of course not characteristic of solar variability, but the fact that the observational errors are quite small greatly facilitates the analysis of the other components. The recent data suggest that the current cycle is starting late and may be relatively weak. The data analyzed in this paper can be found at the National Solar Observatory web site http://nsosp.nso.edu/cak_mon/, or by file transfer protocol at ftp://ftp.nso.edu/idl/cak.parameters.

  17. Longitudinal profile monitors using Coherent Smith-Purcell radiation

    NASA Astrophysics Data System (ADS)

    Andrews, H. L.; Bakkali Taheri, F.; Barros, J.; Bartolini, R.; Cassinari, L.; Clarke, C.; Le Corre, S.; Delerue, N.; Doucas, G.; Fuster-Martinez, N.; Konoplev, I.; Labat, M.; Perry, C.; Reichold, A.; Stevenson, S.; Vieille Grosjean, M.

    2014-03-01

    Coherent Smith-Purcell radiation has the potential of providing information on the longitudinal profile of an electron bunch. The E-203 experiment at the FACET User Facility measures bunch profiles from the SLAC linac in the hundreds of femtoseconds range and the SPESO collaboration at Synchrotron SOLEIL is planning to make an accurate 2D map of the Coherent Smith-Purcell Radiation emission.

  18. Dermatologic features of Smith-Magenis syndrome.

    PubMed

    Guérin-Moreau, Morgane; Colin, Estelle; Nguyen, Sylvie; Andrieux, Joris; de Leersnyder, Hélène; Bonneau, Dominique; Martin, Ludovic

    2015-01-01

    Smith-Magenis syndrome (SMS) is characterized by distinctive facial and skeletal features, developmental delay, cognitive impairment, and behavioral abnormalities, including self-injurious behaviors. We aimed to investigate whether cutaneous features are common in SMS. We performed a complete skin examination in 20 young SMS patients. Skin features secondary to self-injurious behavior, such as bites, abrasions, dystrophic scars, limited spots of hyperkeratosis, anomalies of the nails, and whitlows, were found in the majority of patients. Acral pachydermia and fissured plantar keratoderma were common. Xerosis was constant and associated with extensive keratosis pilaris in the majority of patients. Dermatofibromas were frequent in older patients. The hair was dense and shiny, with an unusual hairline. Eyelash trichomegaly and heavy brows were common, as well as folliculitis on the back. The skin features of SMS have rarely been reported in the literature. Some of these are the consequence of neurobehavioral features, but some cutaneous features and abnormalities of appendages have not been reported in other related syndromes. Skin manifestations of SMS are varied, sometimes induced by self-injurious behavior and sometimes more specific. It remains to be determined whether the combination of the two kinds of signs could contribute to early diagnosis of the syndrome. PMID:25684097

  19. Congenital Scoliosis in Smith–Magenis Syndrome

    PubMed Central

    Li, Zheng; Shen, Jianxiong; Liang, Jinqian; Sheng, Lin

    2015-01-01

    Abstract The Smith–Magenis syndrome (SMS) is a complex and rare congenital condition that is characterized by minor craniofacial anomalies, short stature, sleep disturbances, behavioral, and neurocognitive abnormalities, as well as variable multisystemic manifestations. Little is reported about spinal deformity associated with this syndrome. This study is to present a case of scoliosis occurring in the setting of SMS and explore the possible mechanisms between the 2 diseases. The patient is a 13-year-old Chinese female with congenital scoliosis and Tetralogy of Fallot, mental retardation, obstructive sleep apnea, hypertrophy of tonsil, conductive hearing loss, and agenesis of the epiglottis. An interphase fluorescent in situ hybridization at chromosome 17p11.2 revealed a heterozygous deletion, confirming a molecular diagnosis of SMS. She underwent a posterior correction at thoracic 1-lumbar 1 (T1-L1) levels, using the Moss-SI spinal system. At 6-month follow-up, the patient was clinically pain free and well balanced. Plain radiographs showed solid spine fusion with no loss of correction. Congenital cardiac disease, immunodeficiency, and severe behavioral problems can affect the surgical outcome following spine fusion and need to be taken into consideration for the surgeon and anesthesiologist. Scoliosis is not uncommon among patients with SMS, and there is a potential association between congenital scoliosis and SMS. The potential mechanisms in the pathogenesis of congenital scoliosis of SMS included retinoic acid-induced 1 (RAI1) microdeletion and RAI1 gene point mutation. PMID:25929900

  20. Smith-Lemli-Opitz syndrome among Arabs.

    PubMed

    Al-Owain, M; Imtiaz, F; Shuaib, T; Edrees, A; Al-Amoudi, M; Sakati, N; Al-Hassnan, Z; Bamashmous, H; Rahbeeni, Z; Al-Ameer, S; Faqeih, E; Meyer, B; Al-Hashem, A; Garout, W; Al-Odaib, A; Rashed, M; Al-Aama, J Y

    2012-08-01

    Smith-Lemli-Opitz syndrome (SLOS) is an autosomal recessive disorder of variable presentation caused by the deficiency of the 3?- hydroxycholesterol ?(7) - reductase. Over the past 10 years, our biochemical laboratory has screened 191 plasma samples for possible SLOS, measuring the plasma cholesterol and 7-dehydrocholesterol using gas chromatography-mass spectrometry (GC-MS). The SLOS was confirmed in only five Arab patients with growth retardation, global developmental delay, dysmorphic features, and 2-3 toe syndactyly, among other findings. All cases represented moderate to severe form of SLOS. One patient had a unique cardiovascular malformation (cor triatriatum with significant obstruction of the right pulmonary veins). Two previously reported N287K (861 C>A) and R352Q (1055 G>A) and a novel R352L (1055 G>T) mutations were identified in the DHCR7 gene in these patients. The paper sheds light on this rare disease among Arabs and reviews all reported SLOS cases in the Arab population. PMID:21696385

  1. MAGNETIZED GAS IN THE SMITH HIGH VELOCITY CLOUD

    SciTech Connect

    Hill, Alex S.; McClure-Griffiths, Naomi M.; Mao, S. A.; Benjamin, Robert A.; Lockman, Felix J. E-mail: naomi.mcclure-griffiths@csiro.au E-mail: benjamir@uww.edu

    2013-11-01

    We report the first detection of magnetic fields associated with the Smith High Velocity Cloud. We use a catalog of Faraday rotation measures toward extragalactic radio sources behind the Smith Cloud, new H I observations from the Robert C. Byrd Green Bank Telescope, and a spectroscopic map of H? from the Wisconsin H-Alpha Mapper Northern Sky Survey. There are enhancements in rotation measure (RM) of ?100 rad m{sup –2} which are generally well correlated with decelerated H? emission. We estimate a lower limit on the line-of-sight component of the field of ?8 ?G along a decelerated filament; this is a lower limit due to our assumptions about the geometry. No RM excess is evident in sightlines dominated by H I or H? at the velocity of the Smith Cloud. The smooth H? morphology of the emission at the Smith Cloud velocity suggests photoionization by the Galactic ionizing radiation field as the dominant ionization mechanism, while the filamentary morphology and high (?1 Rayleigh) H? intensity of the lower-velocity magnetized ionized gas suggests an ionization process associated with shocks due to interaction with the Galactic interstellar medium. The presence of the magnetic field may contribute to the survival of high velocity clouds like the Smith Cloud as they move from the Galactic halo to the disk. We expect these data to provide a test for magnetohydrodynamic simulations of infalling gas.

  2. Angular radiation pattern of Smith-Purcell radiation

    SciTech Connect

    Gover, A.; Dvorkis, P.; Elisha, U.

    1984-10-01

    The power radiation pattern of Smith-Purcell radiation is measured at various latitudes and azimuth angles relative to the electron beam. The experimental data are used to evaluate the various models and the physical mechanisms previously suggested to describe Smith-Purcell radiation. Good agreement is observed between the experimental data and the theoretical curves derive from Van den Berg's analysis (J. Opt. Soc. Am. 63, 1588 (1973)). The radiation mechanism proposed by Salisbury (J. Opt. Soc. Am. 60, 1279 (1970)) was analyzed an shown to be too small to account for the measured radiation. The experimantal and Van den Berg's theory predict stronger emission at azimuthal angles off the plane perpendicular to the gratings. This observation leads to conclusions regarding the design of optical cavities for Smith-Purcell free-electron lasers and orotron millimeter-wavelength-radiation tube devices.

  3. Revision of the genus Heteranassa Smith, 1899 (Lepidoptera, Erebidae, Omopterini)

    PubMed Central

    Homziak, Nicholas; Hopkins, Heidi; Miller, Kelly B.

    2015-01-01

    Abstract Heteranassa Smith (Erebidae, Omopterini), native to the southwestern United States and Mexico, includes two recognized species, namely Heteranassa mima (Harvey) and Heteranassa fraterna Smith. These are separated mainly by subtle differences in wing color and pattern, leading to speculation about the validity of the described species. This study examines variation in external and internal morphology across the geographic range of the genus, aiming to clarify species limits, describe morphology, and provide a comprehensive assessment of variation within the genus. Results indicate that Heteranassa fraterna syn. n., is a junior synonym of Heteranassa mima. PMID:26692786

  4. Electron Bunch Length Diagnostic With Coherent Smith-Purcell Radiation

    SciTech Connect

    Nguyen, D.C.

    1997-05-12

    The authors have designed a new technique for measuring subpicosecond electron bunch lengths using coherent Smith-Purcell radiation. This new diagnostic technique involves passing the electron beam in close proximity of a grating with a period comparable to the electron bunch length. The emitted Smith-Purcell radiation will have a coherent component whose angular position and distribution are directly related to the electron bunch length and longitudinal profile, respectively. This new diagnostic technique is inherently simple, inexpensive and non-intercepting. The authors show that the new technique is also scaleable to femtosecond regime.

  5. Description of floodplains and wetlands, Deaf Smith County site, Texas

    SciTech Connect

    Not Available

    1986-11-01

    Floodplains and wetlands are important features of the Texas Panhandle landscape, and are found on the Deaf Smith County site and in its vicinity. Use or disturbance of floodplains and wetlands in relation to the Civilian Radioactive Waste Management Program is subject to environmental review requirements implementing two Executive Orders. This report provides general information on playa wetlands in the Texas Panhandle, and describes and maps floodplains and wetlands on the Deaf Smith site and in its vicinity. The report is based on the published literature, with information from limited field reconnaissance included.

  6. 75 FR 37462 - Official Trail Marker for the Captain John Smith Chesapeake National Historic Trail

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-29

    ...Service Official Trail Marker for the Captain John Smith Chesapeake National Historic Trail...official trail marker insignias of the Captain John Smith Chesapeake National Historic Trail...The primary author of this document is John Maounis, Superintendent, Captain...

  7. Lee Smith's Fair and Tender Ladies: the female espistolary novel and the construction of knowledge 

    E-print Network

    Grubbs, Amy Marie

    1994-01-01

    This thesis focuses on how Lee Smith, a North Carolina writer, uses the traditional female epistolary form in a revolutionary way in her 1988 novel Fair and Tender Ladies. Smith's use of the form is revolutionary because, ...

  8. Beyond Sweetgrass: The Life and Art of Jaune Quick-to-See Smith

    E-print Network

    Murphy, Joni Lisa

    2008-10-27

    This dissertation is a brief monographic study of noted American Indian artist-Jaune Quick-to-See Smith. No such study of Smith has been completed to date. This particular study is different because it consists of a Native ...

  9. 77 FR 13593 - PowerSmith Cogeneration Project, LP; Notice of Request for Waiver

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-07

    ...EL12-37-000; QF86-36-006] PowerSmith Cogeneration Project, LP; Notice of Request for...18 CFR 292.205(c), PowerSmith Cogeneration Project, LP (PowerSmith) filed a...Regulations for the topping- cycle cogeneration facility owned and operated by...

  10. 76 FR 4648 - PowerSmith Cogeneration Project, LP; Notice of Filing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-26

    ...EL11-15-000; QF86-36-005] PowerSmith Cogeneration Project, LP; Notice of Filing January...that on January 13, 2011, PowerSmith Cogeneration Project, LP (PowerSmith), pursuant...Regulations for the topping-cycle cogeneration facility owned and operated by...

  11. A Cabinet of Mathematical Curiosities at Teachers College: David Eugene Smith's Collection

    ERIC Educational Resources Information Center

    Murray, Diane R.

    2012-01-01

    This dissertation is a history of David Eugene Smith's collection of historical books, manuscripts, portraits, and instruments related to mathematics. The study analyzes surviving documents, images, objects, college announcements and catalogs, and secondary sources related to Smith's collection. David Eugene Smith (1860-1944) travelled…

  12. 76 FR 60733 - Drawbridge Operation Regulations; Narrow Bay, Smith Point, NY

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-30

    ...SUPPLEMENTARY INFORMATION: The Smith Point Bridge, across Narrow Bay, mile 6.1, between Smith Point and Fire Island, New York...temporary deviation the Smith Point Bridge may open only one of...schedule immediately at the end of the designated time...

  13. 77 FR 2317 - Captain John Smith Chesapeake National Historic Trail Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-17

    ...INTERIOR National Park Service Captain John Smith Chesapeake National Historic Trail...that the Advisory Committee on the Captain John Smith Chesapeake National Historic Trail...tracing the 1607-1609 voyages of Captain John Smith to chart the land and waterways...

  14. 77 FR 12324 - Captain John Smith Chesapeake National Historic Trail Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-29

    ...INTERIOR National Park Service Captain John Smith Chesapeake National Historic Trail...that the Advisory Committee on the Captain John Smith Chesapeake National Historic Trail...tracing the 1607-1609 voyages of Captain John Smith to chart the land and waterways...

  15. 77 FR 64352 - Notice of Meeting for Captain John Smith Chesapeake National Historic Trail Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-19

    ...4251 SZM] Notice of Meeting for Captain John Smith Chesapeake National Historic Trail...that the Advisory Committee on the Captain John Smith Chesapeake National Historic Trail...tracing the 1607-1609 voyages of Captain John Smith to chart the land and waterways...

  16. 76 FR 52691 - Captain John Smith Chesapeake National Historic Trail Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-23

    ...INTERIOR National Park Service Captain John Smith Chesapeake National Historic Trail...that the Advisory Committee on the Captain John Smith Chesapeake National Historic Trail...tracing the 1607-1609 voyages of Captain John Smith to chart the land and waterways...

  17. 76 FR 26767 - Captain John Smith Chesapeake National Historic Trail Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-09

    ...INTERIOR National Park Service Captain John Smith Chesapeake National Historic Trail...that the Advisory Committee on the Captain John Smith Chesapeake National Historic Trail...tracing the 1607-1609 voyages of Captain John Smith to chart the land and waterways...

  18. 2010 MSU Horticulture Gardens Glass Art by Craig Mitchell Smith Photos by Art and Marlene Cameron

    E-print Network

    Isaacs, Rufus

    2010 MSU Horticulture Gardens ­ Glass Art by Craig Mitchell Smith Photos by Art and Marlene Cameron #12;2010 MSU Horticulture Gardens ­ Glass Art by Craig Mitchell Smith Photos by Art and Marlene Cameron #12;2010 MSU Horticulture Gardens ­ Glass Art by Craig Mitchell Smith Photos by Art and Marlene

  19. 77 FR 13593 - PowerSmith Cogeneration Project, LP; Notice of Request for Waiver

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-07

    ... Energy Regulatory Commission PowerSmith Cogeneration Project, LP; Notice of Request for Waiver Take... Act of 1978 (PURPA), as amended, 18 CFR 292.205(c), PowerSmith Cogeneration Project, LP (PowerSmith...-205(a)(1) of the Commission's Regulations for the topping- cycle cogeneration facility owned...

  20. 77 FR 2317 - Captain John Smith Chesapeake National Historic Trail Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-17

    ... National Park Service Captain John Smith Chesapeake National Historic Trail Advisory Council AGENCY... Captain John Smith Chesapeake National Historic Trail will hold a meeting via conference call. Designated... voyages of Captain John Smith to chart the land and waterways of the Chesapeake Bay. This meeting...

  1. 77 FR 64352 - Notice of Meeting for Captain John Smith Chesapeake National Historic Trail Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-19

    ... National Park Service Notice of Meeting for Captain John Smith Chesapeake National Historic Trail Advisory... Advisory Committee on the Captain John Smith Chesapeake National Historic Trail will hold a meeting...-1609 voyages of Captain John Smith to chart the land and waterways of the Chesapeake Bay. This...

  2. Trace Processors Eric Rotenberg*, Quinn Jacobson, Yiannakis Sazeides, Jim Smith

    E-print Network

    Moshovos, Andreas

    .O. Box 1331 Piscataway, NJ 08855-1331, USA Telephone: + Intl. 908-562-3966 #12;Trace Processors Eric the value of successively doubling the number of distributed ele- ments. (ii) A trace processor with dataTrace Processors Eric Rotenberg*, Quinn Jacobson, Yiannakis Sazeides, Jim Smith Computer Sciences

  3. L.C. Smith College of Engineering and Computer Science

    E-print Network

    Mohan, Chilukuri K.

    L.C. Smith College of Engineering and Computer Science DEPARTMENT OF CIVIL AND ENVIRONMENTAL ENGINEERING Graduate Program Profiles for: Master of Science in Civil Engineering Master of Science in Environmental Engineering Master of Science in Environmental Engineering Science Master of Science

  4. Bark and ERB Bilinear Transforms Julius O. Smith III

    E-print Network

    Smith III, Julius Orion

    Bark and ERB Bilinear Transforms Julius O. Smith III Center for Computer Research in Music map to achieve a frequency warping nearly identical to that of the Bark frequency scale is described example is included which illustrates improvements due to carrying out the design over a Bark scale

  5. Smith and Valley-Gray to Lead NASP

    ERIC Educational Resources Information Center

    Deupree, Charles

    2011-01-01

    The 2011 elections are complete and Amy Smith has been elected to lead NASP in 2012. Amy has a long history of serving her state and national professional organizations, most recently as NASP program manager for advocacy and before that as the Pennsylvania delegate and Northeast Region delegate representative. She served the Association of School…

  6. SELF ADAPTATION IN EVOLUTIONARY ALGORITHMS JAMES EDWARD SMITH

    E-print Network

    Smith, James E.

    SELF ADAPTATION IN EVOLUTIONARY ALGORITHMS JAMES EDWARD SMITH A thesis submitted in partial towards the study of adaptation in Evolutionary Algorithms, and towards the design of robust search SELF ADAPTATION IN EVOLUTIONARY ALGORITHMS 1 Abstract 2 Self-Adaptation in Evolutionary Algorithms 7

  7. Harry Smith — recipient of the 2008 Molecular Ecology Prize

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Harry Smith is a scholar, mentor, internationally renowned researcher, eloquent speaker and author, pioneering journal editor and highly valued colleague who has contributed greatly in multiple ways to plant science and the community. He richly deserves the honour of the Molecular Ecology Prize....

  8. PEACHES and Peers Massimiliano Pala and Sean W. Smith

    E-print Network

    Smith, Sean W.

    PEACHES and Peers Massimiliano Pala and Sean W. Smith Computer Science Department, Dartmouth network. In particular we present the PEACH protocol and a PEACH Enabled System (PEACHES) which of this work is PEACH, a scalable system for PKI resources lookup. 2 Background In order to provide

  9. SMITH AND BARGHNONCONSCIOUS EFFECTS OF POWER NONCONSCIOUS EFFECTS OF POWER

    E-print Network

    Bargh, John A.

    SMITH AND BARGHNONCONSCIOUS EFFECTS OF POWER NONCONSCIOUS EFFECTS OF POWER ON BASIC APPROACH to the approach/inhibition theory of power (Keltner, Gruenfeld, & Anderson, 2003), having power should be associated with the approach system, and lacking power with the avoidance system. However

  10. PHYSICS (Div. III) Chair: Professor DAVID TUCKER-SMITH

    E-print Network

    Aalberts, Daniel P.

    PHYSICS (Div. III) Chair: Professor DAVID TUCKER-SMITH Professors: AALBERTS, S. BOLTON*, K. JONES a laser work? What is a black hole? What are the fundamental building blocks of the universe? Physics majors and Astrophysics majors study these and related questions to understand the physical world around

  11. A Dialog Control Algorithm and Its Performance Ronnie W. Smith*

    E-print Network

    contains a model of the device to be repaired, debugging and repair proce- dures, voice recognitionA Dialog Control Algorithm and Its Performance Ronnie W. Smith* Dept. of Computer Science Duke awb@cs.duke.edu Abstract A pragmatic architecture for voice dialog ma- chines aimed at the equipment

  12. New Maps for Old? A Reply to Smith.

    ERIC Educational Resources Information Center

    Pickles, John

    1986-01-01

    Pickles replies that Smith's critique masks the concrete experience of everyday understanding. The issue of education is not about the transmission of information, but one about how we produce and reproduce our social world. Education must permit rational discourse and decision making within the context of a moral community. (CJH)

  13. 035 Smith Hall Project Number 035-96-002

    E-print Network

    035 Smith Hall Project Number 035-96-002 Surveyor KWB/DCK Sample Date 1/12/2000 Flr Location Samp/DCK Sample Date 1/12/2000 Flr Location Samp# Description Code N.D. Pos Quan Unit Fri Cond Rate Amos Chrys

  14. Creating Models of Truss Structures with Optimization Jeffrey Smith

    E-print Network

    engineering, to quickly create novel and physically realistic truss structures such as bridges and towers, us category of man-made structures, including bridges (Figure 1), water towers, cranes, roof support trussesCreating Models of Truss Structures with Optimization Jeffrey Smith Carnegie Mellon University

  15. Closing down the Conversation? A Reply to Smith and Hodkinson

    ERIC Educational Resources Information Center

    Hammersley, Martyn

    2009-01-01

    In their response, "Challenging Neorealism" (pp. 30-39) to the author's article, Smith and Hodkinson begin by characterising their discussions over the years as failing to lead to any change in view; though, toward the end, they suggest that they have learned something from the process, as indeed the author has. Although the productiveness of any…

  16. Smith-Magenis Syndrome: Genetic Basis and Clinical Implications

    ERIC Educational Resources Information Center

    Finucane, Brenda; Haas-Givler, Barbara

    2009-01-01

    Smith-Magenis syndrome (SMS) is a neurobehavioral disorder associated with deletions and mutations of the "RAI1" gene on chromosome 17p11.2. Clinical features of the syndrome include intellectual disability, sleep disturbance, craniofacial differences, and a distinctive profile of stereotypic and self-injurious behaviors. Although the functional…

  17. The Garrett Lee Smith Memorial Suicide Prevention Program

    ERIC Educational Resources Information Center

    Goldston, David B.; Walrath, Christine M.; McKeon, Richard; Puddy, Richard W.; Lubell, Keri M.; Potter, Lloyd B.; Rodi, Michael S.

    2010-01-01

    In response to calls for greater efforts to reduce youth suicide, the Garrett Lee Smith (GLS) Memorial Act has provided funding for 68 state, territory, and tribal community grants, and 74 college campus grants for suicide prevention efforts. Suicide prevention activities supported by GLS grantees have included education, training programs…

  18. TROPHIC DYNAMICS OF STRIPED BASS IN SMITH MOUNTAIN LAKE, VIRGINIA

    EPA Science Inventory

    We examined the adequacy of the forage base to meet demand of striped bass in Smith Mountain Lake, Virginia. In regards to prey supply, mean alewife biomass from 1993-1998 was 37 kg/ha and mean gizzard shad biomass from 1990-1997 was 112 kg/ha. Mean annual alewife surplus produ...

  19. Modeling Building Thermal Response to HVAC Zoning Virginia Smith

    E-print Network

    McAuliffe, Jon

    Modeling Building Thermal Response to HVAC Zoning Virginia Smith Department of Computer Science to enable room-level zoning where each room is conditioned individually based on its occupancy vision is to minimize this energy wastage through room-level zoning, where each room is conditioned

  20. L.C. SMITH COLLEGE OF ENGINEERING AND COMPUTER SCIENCE

    E-print Network

    Mohan, Chilukuri K.

    , an environmental chemistry and a microbiology laboratory, a geosynthetics laboratory, a geofoam research laboratoryL.C. SMITH COLLEGE OF ENGINEERING AND COMPUTER SCIENCE DEPARTMENT OF CIVIL AND ENVIRONMENTAL IN ENVIRONMENTAL ENGINEERING MASTER OF SCIENCE IN ENVIRONMENTAL ENGINEERING SCIENCE MASTER OF SCIENCE

  1. Titan's atomic and molecular nitrogen tori H. T. Smith,1

    E-print Network

    Johnson, Robert E.

    Titan's atomic and molecular nitrogen tori H. T. Smith,1 R. E. Johnson,1 and V. I. Shematovich2] Shematovich et al. recently showed plasma induced sputtering in Titan's atmosphere is a source of neutral a toroidal nitrogen cloud roughly centered at Titan's orbital radius but gravitationally bound to Saturn

  2. J. E. SMITH1, 2 , L. KORSTEN1

    E-print Network

    dematium is the cause of a new fungal stem disease on cowpea in South Africa. The pre-penetration and infection process of this fungus on cowpea stems was studied by light microscopy and SEM. Conidia began of a new anthracnose disease of cowpea (Vigna unguiculata (L.) Walp.) in South Africa (Smith & Aveling

  3. Pharmacological Cognitive Enhancers: Comment on Smith and Farah (2011)

    ERIC Educational Resources Information Center

    Elliott, Glen R.; Elliott, Mark D.

    2011-01-01

    Smith and Farah (2011) provided a thought-provoking and perhaps deliberately provocative literature review of the use of stimulants to improve cognitive functioning in humans. They addressed the apparently increasing willingness of individuals mostly in the United States to use stimulants for this purpose and then summarized published literature…

  4. James M. Coughlan Smith-Kettlewell Eye Research Institute

    E-print Network

    Coughlan, James M.

    of the Problem 3-D lines in Manhattan scene project to lines on uv image plane. cr ar fu rr rr = cr br fv rr rrJames M. Coughlan Smith-Kettlewell Eye Research Institute Manhattan World: Orientation and Outlier Detection by Bayesian Inference #12;Application of the statistics of edges: Manhattan World Many scenes

  5. Factors Affecting Sea Lamprey Egg Survival STEPHEN J. SMITH

    E-print Network

    Marsden, Ellen

    Factors Affecting Sea Lamprey Egg Survival STEPHEN J. SMITH 1 AND J. ELLEN MARSDEN* Rubenstein; for example, the majority (85%) of sea lamprey eggs are washed out of the nest, and the survival rate of these eggs is unknown. We examined the role of predation and substrate on egg survival in the laboratory

  6. Karen Smith: Language Arts Educator of the Year

    ERIC Educational Resources Information Center

    Hudelson, Sarah

    2009-01-01

    This article honors Karen Smith, who has been given NCTE's Outstanding Educator in the English Language Arts award for 2009. Through the voices of many colleagues and former students, the article celebrates Karen as a teacher, learner, mentor, collaborator, scholar, storyteller, and visionary thinker and doer.

  7. Lower bounds for Smith's rule in stochastic machine scheduling

    E-print Network

    Al Hanbali, Ahmad

    , The Netherlands, carolinetjes@gmail.com 2 TU Dortmund, Robotics Research Institute, 44227 Dortmund, Germany, uwe, The Netherlands, m.uetz@utwente.nl Abstract We consider the problem to minimize the weighted sum of completion] showed that schedul- ing the jobs according to the WSPT rule ­also known as Smith's rule­ has

  8. Smith Assists in Superstorm Sandy Relief Efforts | Poster

    Cancer.gov

    By Cathy McClintock, Guest Writer It should have been routine by now for a 30-year volunteer firefighter/ emergency medical technician from Thurmont, Md., but it wasn’t. That first night, as Ross Smith, IT security, looked across the Hudson River from Jersey City, N.J., he saw an unusually dark New York skyline.

  9. SAMPLE COVER LETTER for BIOTECH INTERNSHIP Aaron Smith

    E-print Network

    Hickey, Timothy J.

    SAMPLE COVER LETTER for BIOTECH INTERNSHIP Aaron Smith 12 Echo Street Cambridge, MA 55555 September in biology gave me a strong background in biology, along with additional skills gained through coursework in biotechnology, which will allow me to apply those skills to a position in the biotechnology arena. Last summer I

  10. Reach Survival Estimates, 2008 Bill Muir, Steve Smith, Doug Marsh,

    E-print Network

    Reach Survival Estimates, 2008 Bill Muir, Steve Smith, Doug Marsh, John Williams, and Jim FaulknerDalles JohnDay Hells Canyon Oxbow Brownlee Priest Rapids Wanapum Rock Island Rocky Reach Wells Chief Joseph. . Date at McNary Number released McNary to John Day Dam John Day to Bonneville Dam McNary to Bonneville

  11. Family-Owned Business Valuation Clint Bentz Boldt, Carlisle + Smith

    E-print Network

    Family-Owned Business Valuation Clint Bentz ­ Boldt, Carlisle + Smith Tuesday, February 10, 2015 Kroc Community Center, Salem OR Background Business valuation is a topic of great importance for family for family business valuation. We will also cover some common questions such as what are the fundamental

  12. Modular Internet Programming with Cells Ran Rinat and Scott Smith

    E-print Network

    Smith, Scott F.

    of a cell. Here is a brief definition. Cells are deployable containers of objects and code. They exposeModular Internet Programming with Cells Ran Rinat and Scott Smith Department of Computer Science The Johns Hopkins University Baltimore, Maryland, USA {rinat, scott}@cs.jhu.edu http://www.cs.jhu.edu/~scott/cells

  13. Reconstructing the Evolution of the Human Mind Eric Alden Smith

    E-print Network

    Smith, Eric Alden

    Reconstructing the Evolution of the Human Mind Eric Alden Smith U of Washington [Copy-edited 10 that the primary object of explanation is human behavior in its adaptive context. The study of "mind/04; Revised 11/05] To appear in The Evolution of Mind, ed. S. Gangestad and J. Simpson. NY: Guilford

  14. Evolutionary Ecology Research, 2001, 3: 331344 2001 Adam R. Smith

    E-print Network

    O'Donnell, Sean

    that group behavioural defence against ants is a key adaptive feature associated with the evolution of swarm-founding. The hypothesis that the evolution of nest envelopes obviated chemical defence against ants was not as wellEvolutionary Ecology Research, 2001, 3: 331­344 © 2001 Adam R. Smith Correlated evolution of colony

  15. THE SEAWEED INDUSTRIES OF JAPAN. By HUGH M. SMITH,

    E-print Network

    THE SEAWEED INDUSTRIES OF JAPAN. By HUGH M. SMITH, Deputy U. S. Fish Commissioner, 133 #12;Blank OF .. SLE NDER" KAN T EN. K A NT EN, OR S EAWE ED ISINGL ASS. #12;THE SEAWEED INDUSTRIES OF JAPAN. By. HUGH M. SMI'rH, Deputy U. S. Fish Commissioner, Seaweeds ar~ mong the most valuable of the aquatic

  16. Heating the Outer Heliosphere by Pickup Charles W. Smith

    E-print Network

    Richardson, John

    Heating the Outer Heliosphere by Pickup Protons Charles W. Smith£ , Philip A. Isenberg£ , William H the ability of a turbulent cascade within the solar wind to heat the thermal protons. Several sources of energy are required to accom- plish the observed heating. Wind shear and shocks originating

  17. Looking east at canal and R. Paul Smith Power Station. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Looking east at canal and R. Paul Smith Power Station. The dark trestle at right center carried the spur track to coal unloading facilities located in the space now occupied by the coal pile. - Potomac Edison Company, Chesapeake & Ohio Canal Bridge, Spanning C & O Canal South of U.S. 11, Williamsport, Washington County, MD

  18. A NEW SET OF THERMAL CONDUCTIVITY MEASUREMENTS Michael Smith1

    E-print Network

    Jamieson, Bruce

    A NEW SET OF THERMAL CONDUCTIVITY MEASUREMENTS Michael Smith1 ,Bruce Jamieson1 2 1 Dept. of Civil, AB, Canada ABSTRACT: A new set of thermal conductivity measurements collected over the course of one for empirical relationships between thermal conductivity and layer density. Further subsetting by moist or dry

  19. James Webb Space Telescope (JWST) Eric P. Smith

    E-print Network

    Rathbun, Julie A.

    1! James Webb Space Telescope (JWST) Eric P. Smith Program Status and Replan October 2011 #12 on line:" http://www.jwst.nasa.gov/resources/ JamesWebbSpaceTelescope;2! Telescope Comparisons! Spitzer Space Telescope Hubble Space Telescope Average US woman (1.6m tall) James

  20. A Domain Wall Theory for Ferroelectric Hysteresis Ralph C. Smith

    E-print Network

    A Domain Wall Theory for Ferroelectric Hysteresis Ralph C. Smith Center for Research in Scientific.hom@lmco.com Abstract This paper addresses the modeling of hysteresis in ferroelectric materials through consideration for the anhysteretic polarization that occurs in the absence of domain wall pinning. In the second step, hysteresis

  1. A Domain Wall Theory for Ferroelectric Hysteresis Ralph C. Smith

    E-print Network

    A Domain Wall Theory for Ferroelectric Hysteresis Ralph C. Smith Center for Research in Scienti c.hom@lmco.com Abstract This paper addresses the modeling of hysteresis in ferroelectric materials through consideration for the anhysteretic polarization that occurs in the absence of domain wall pinning. In the second step, hysteresis

  2. Benzene Exposure and Risk of Non-Hodgkin Lymphoma Martyn T. Smith, Rachael M. Jones, and Allan H. Smith

    E-print Network

    California at Berkeley, University of

    Benzene Exposure and Risk of Non-Hodgkin Lymphoma Martyn T. Smith, Rachael M. Jones, and Allan H of California, Berkeley, California Abstract Exposure to benzene, an important industrial chemical and component studies that identified probable occupational exposures to benzene and NHL morbidity or mortality. We

  3. SMITH: a LIMS for handling next-generation sequencing workflows

    PubMed Central

    2014-01-01

    Background Life-science laboratories make increasing use of Next Generation Sequencing (NGS) for studying bio-macromolecules and their interactions. Array-based methods for measuring gene expression or protein-DNA interactions are being replaced by RNA-Seq and ChIP-Seq. Sequencing is generally performed by specialized facilities that have to keep track of sequencing requests, trace samples, ensure quality and make data available according to predefined privileges. An integrated tool helps to troubleshoot problems, to maintain a high quality standard, to reduce time and costs. Commercial and non-commercial tools called LIMS (Laboratory Information Management Systems) are available for this purpose. However, they often come at prohibitive cost and/or lack the flexibility and scalability needed to adjust seamlessly to the frequently changing protocols employed. In order to manage the flow of sequencing data produced at the Genomic Unit of the Italian Institute of Technology (IIT), we developed SMITH (Sequencing Machine Information Tracking and Handling). Methods SMITH is a web application with a MySQL server at the backend. Wet-lab scientists of the Centre for Genomic Science and database experts from the Politecnico of Milan in the context of a Genomic Data Model Project developed SMITH. The data base schema stores all the information of an NGS experiment, including the descriptions of all protocols and algorithms used in the process. Notably, an attribute-value table allows associating an unconstrained textual description to each sample and all the data produced afterwards. This method permits the creation of metadata that can be used to search the database for specific files as well as for statistical analyses. Results SMITH runs automatically and limits direct human interaction mainly to administrative tasks. SMITH data-delivery procedures were standardized making it easier for biologists and analysts to navigate the data. Automation also helps saving time. The workflows are available through an API provided by the workflow management system. The parameters and input data are passed to the workflow engine that performs de-multiplexing, quality control, alignments, etc. Conclusions SMITH standardizes, automates, and speeds up sequencing workflows. Annotation of data with key-value pairs facilitates meta-analysis. PMID:25471934

  4. Defenses and morality: Adam Smith, Sigmund Freud, and contemporary psychoanalysis.

    PubMed

    Gabrinetti, Paul A; Özler, Sule

    2014-10-01

    In this paper we follow the development and transmission of moral learning from Adam Smith's impartial spectator to Sigmund Freud's superego and then to contemporary psychoanalysis. We argue that defenses are an integral component in the acquisition of any moral system. Elaborating on this argument, we assert that there is a progression from defensive systems that are "closed" to defensive systems that are "open," as defined in a recent work by Novick and Novick. The former system is "static, avoids reality, and is characterized by power dynamics, sadomasochism, and omnipotent defense." The latter, on the other hand, is a system that allows for "joy, creativity, spontaneity, love and it is attuned to reality." Furthermore, while Smith and Freud's systems are more one-person systems of defense, contemporary psychoanalysis has moved to more of a two-person system. PMID:25247288

  5. Constitutive relations associated with the Mott-Smith distribution function

    USGS Publications Warehouse

    Nathenson, M.; Baganoff, D.

    1973-01-01

    It is shown that the distribution function assumed by Mott-Smith determines a unique relation between heat flux, stress, and fluid velocity given by q = (3/2)??u, i.e., it provides a constitutive relation for heat flux, and it also determines a simple expression for this ratio of third-order central moments Q = . These expressions allow the equation of transfer for c x2 to be cast in a form that yields a nonlinear constitutive relation for stress. The results obtained from the Mott-Smith ansatz are compared with the theory of Baganoff and Nathenson and results from a numerical solution of the Boltzmann equation for shock-wave structure obtained by Hicks and Yen.

  6. Building Energy Audit Report for Camp Smith, HI

    SciTech Connect

    Chvala, William D.; De La Rosa, Marcus I.; Brown, Daryl R.; Dixon, Douglas R.

    2010-09-30

    A detailed energy assessment was performed by a team of engineers from Pacific Northwest National Laboratory (PNNL) under contract to the Department of Energy/Federal Energy Management program (FEMP). The effort used the Facility Energy Decision System (FEDS) model to determine how energy is consumed at Camp Smith, identify the most cost-effective energy retrofit measures, and calculate the potential energy and cost savings. This report documents the results of that assessment.

  7. Smith Newton Vehicle Performance Evaluation - 3rd Quarter 2012 (Brochure)

    SciTech Connect

    Not Available

    2013-03-01

    The Fleet Test and Evaluation Team at the U.S. Department of Energy's National Renewable Energy Laboratory is evaluating and documenting the performance of electric and plug-in hybrid electric drive systems in medium-duty trucks across the nation. Through this project, Smith Electric Vehicles will build and deploy 500 all-electric medium-duty trucks. The trucks will be deployed in diverse climates across the country.

  8. Smith-Magneis syndrome: behavioural phenotype mimics ADHD

    PubMed Central

    Gnanavel, Sundar

    2014-01-01

    A mentally retarded 7-year-old male child presented with inattention and hyperactivity which was initially diagnosed as attention deficit hyperactivity disorder (ADHD). However, a careful evaluation of symptomatology along with clues provided by specific features of facial dysmorphism in this case along with genetic testing clinched the diagnosis of Smith-Magneis syndrome the behavioural phenotype of which closely resembles ADHD. PMID:24395876

  9. Why Morris, Lazo, and Smith (2004) was published in The Behavior Analyst

    E-print Network

    Morris, Edward K.; Smith, Nathaniel G.; Lazo, Junelyn F.

    2005-01-01

    -179 No.2 (Fall) Why Morris, Lazo, and Smith (2004) Was Published in The Behavior Analyst Edward K. Morris, Nathaniel G. Smith, and Junelyn F. Lazo University of Kansas The Fall 2004 issue of The Behavior Analyst published an article, "Whether, When..., and Why Skinner Published on Biological Participation in Behavior" (Morris, Lazo, & Smith, 2004). We are its authors. Before and after it was pub lished, several colleagues asked why we submitted it to the journal and why it was published there...

  10. Boundaries and interfaces in materials: The David A. Smith symposium

    SciTech Connect

    Pond, R.C. . Dept. of Materials Science and Engineering); Clark, W.A.T. . Dept. of Materials Science and Engineering); King, A.H. . Dept. of Materials Science and Engineering); Williams, D.B. (Lehigh Univ., Bethlehem, PA (United States

    1998-01-01

    Just over a year ago David Smith died. Then the loss of a distinguished scientist and dedicated teacher was mourned. Now it is time to celebrate his accomplishments both as a scientist and teacher and this book serves as a reminder of his many contributions to the field of boundaries and interfaces. Researchers from ten countries contributed their work to the symposium, many of whom were former students of David from his years in Oxford. This emphasizes David's tremendous effect on the career of many established scientists through his role as both a teacher and an advisor. Separate abstracts were prepared for 38 papers in this book.

  11. Accretion Onto the Milky Way: The Smith Cloud

    E-print Network

    Lockman, Felix J

    2015-01-01

    Active gas accretion onto the Milky Way is observed in an object called the Smith Cloud, which contains several million solar masses of neutral and warm ionized gas and is currently losing material to the Milky Way, adding angular momentum to the disk. It is several kpc in size and its tip lies two kpc below the Galactic plane. It appears to have no stellar counterpart, but could contain a stellar population like that of the dwarf galaxy Leo P. There are suggestions that its existence and survival require that it be embedded in a dark matter halo of a few 10^8 solar masses.

  12. Smith Newton Vehicle Performance Evaluation - Gen 2 - Cumulative (Brochure)

    SciTech Connect

    Not Available

    2014-08-01

    The Fleet Test and Evaluation Team at the U.S. Department of Energy's National Renewable Energy Laboratory is evaluating and documenting the performance of electric and plug-in hybrid electric drive systems in medium-duty trucks across the nation. U.S. companies participating in this evaluation project received funding from the American Recovery and Reinvestment Act to cover part of the cost of purchasing these vehicles. Through this project, Smith Electric Vehicles is building and deploying 500 all-electric medium-duty trucks that will be deployed by a variety of companies in diverse climates across the country.

  13. Smith Newton Vehicle Performance Evaluation - Gen2 - 2013 (Brochure)

    SciTech Connect

    Not Available

    2014-04-01

    The Fleet Test and Evaluation Team at the U.S. Department of Energy's National Renewable Energy Laboratory is evaluating and documenting the performance of electric and plug-in hybrid electric drive systems in medium-duty trucks across the nation. U.S. companies participating in this evaluation project received funding from the American Recovery and Reinvestment Act to cover part of the cost of purchasing these vehicles. Through this project, Smith Electric Vehicles is building and deploying 500 all-electric medium-duty trucks that will be deployed by a variety of companies in diverse climates across the country.

  14. Smith Newton Vehicle Performance Evaluation - 1st Quarter 2014 (Brochure)

    SciTech Connect

    Not Available

    2014-04-01

    The Fleet Test and Evaluation Team at the U.S. Department of Energy's National Renewable Energy Laboratory is evaluating and documenting the performance of electric and plug-in hybrid electric drive systems in medium-duty trucks across the nation. U.S. companies participating in this evaluation project received funding from the American Recovery and Reinvestment Act to cover part of the cost of purchasing these vehicles. Through this project, Smith Electric Vehicles is building and deploying 500 all-electric medium-duty trucks that will be deployed by a variety of companies in diverse climates across the country.

  15. No information or horizon paradoxes for Th. Smiths

    NASA Astrophysics Data System (ADS)

    Maes, Christian

    2015-10-01

    The Statistical mechanician in the street (our Th. Smiths) must be surprised upon hearing popular versions of some of today's most discussed paradoxes in astronomy and cosmology. In fact, rather standard reminders of the meaning of thermal probabilities in statistical mechanics appear to answer the horizon problem (one of the major motivations for inflation theory) and the information paradox (related to black hole physics), at least as they are usually presented. Still the paradoxes point to interesting gaps in our statistical understanding of (quantum) gravitational effects.

  16. 75 FR 9441 - Lucas-Smith Automotive, Inc.: Potosi, MO; Notice of Negative Determination Regarding Application...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-02

    ...TA-W-71,388] Lucas-Smith Automotive, Inc.: Potosi, MO; Notice of Negative...and former workers of Lucas- Smith Automotive, Inc., Potosi, Missouri (subject...automobiles to individual owners at an automotive dealership. The workers of the...

  17. An Alternative View of the Instructional Design Process: A Response to Smith and Boling

    ERIC Educational Resources Information Center

    Gibbons, Andrew S.; Yanchar, Stephen C.

    2010-01-01

    A recent literature review by Smith and Boling (2009) critically examines the received view of instructional design in educational technology. Smith and Boling conclude that the foundational literature characterizes design in a way that leads to a constrained understanding of design, especially by novices. They suggest that as a field we move…

  18. The Behavioural Phenotype of Smith-Magenis Syndrome: Evidence for a Gene-Environment Interaction

    ERIC Educational Resources Information Center

    Taylor, L.; Oliver, C.

    2008-01-01

    Background: Behaviour problems and a preference for adult contact are reported to be prominent in the phenotype of Smith-Magenis syndrome. In this study we examined the relationship between social interactions and self-injurious and aggressive/disruptive behaviour in Smith-Magenis syndrome to explore potential operant reinforcement of problem…

  19. Unconscious Odour Conditioning 25 Years Later: Revisiting and Extending "Kirk-Smith, Van Toller and Dodd"

    ERIC Educational Resources Information Center

    Zucco, Gesualdo M.; Paolini, Michela; Schaal, Benoist

    2009-01-01

    The pioneering work by Kirk-Smith, Van Toller, and Dodd [Kirk-Smith, M. D., Van Toller, C., & Dodd, G. H. (1983). "Unconscious odour conditioning in human subjects." "Biological Psychology," 17, 221-231], established that an unnoticed odorant paired with an emotionally meaningful task can influence mood and attitudes when the odorant alone is…

  20. Dyadic Power Theory, Touch, and Counseling Psychology: A Response to Smith, Vogel, Madon, and Edwards (2011)

    ERIC Educational Resources Information Center

    Dunbar, Norah E.; Abra, Gordon

    2012-01-01

    Smith, Vogel, Madon, and Edwards' (2011) recent article tested dyadic power theory (DPT) by examining the use of touch as a compliance-gaining tactic in the conflicts of married couples. In this response, we raise a methodological issue about the touch behaviors examined by Smith et al. and also pose a theoretical critique that their test of DPT…

  1. Principal Investigator/Program Director (Last, First, Middle): Smith, Jane B. Career Goals and Objectives

    E-print Network

    Yang, Sichun

    completed my clinical training in internal medicine and nephrology and continue to maintain my skillsPrincipal Investigator/Program Director (Last, First, Middle): Smith, Jane B. Career Goals Format Page #12;Principal Investigator/Program Director (Last, First, Middle): Smith, Jane This component

  2. A Disciplinary Immigrant. Alexander Smith at the University of Chicago, 1894-1911

    ERIC Educational Resources Information Center

    Cotter, Donald

    2008-01-01

    The publication in 1906 of Alexander Smith's "Introduction to general inorganic chemistry" inaugurated a decisive change in chemical pedagogy in the US, the effects of which are still evident. The nature and extent of Smith's innovations are described through a comparison of his text to its source material and contemporaries. His authoritative…

  3. Generation in the LOLITA system" An engineering approach. Mark H. Smith, Roberto Garigliano, Richard G. Morgan

    E-print Network

    Generation in the LOLITA system" An engineering approach. Mark H. Smith, Roberto Garigliano.h.smith@durham.ac.uk 1 Introduction This short paper Willoutline NLG work in the LOLITA (Large-scale Object of LOLITA itself. Section 3 will then provide an overview of the generation process and outline two specific

  4. Speech/Language Pathologists Reflect on Sally Smith and the Lab School of Washington

    ERIC Educational Resources Information Center

    Learning Disabilities: A Multidisciplinary Journal, 2010

    2010-01-01

    Sally L. Smith had a clear vision of how she thought speech and language services should be integrated into her school, The Lab School of Washington. It was Smith's idea that language therapists should work individually with students to help them make gains in their particular areas of need, as well as to work collaboratively with the teachers,…

  5. 2. VIEW OF THE SMITH NO.3 SITE ARE TO THE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. VIEW OF THE SMITH NO.3 SITE ARE TO THE NORTHEAST. THE BLACKSMITH/MINE CAR REPAIR SHOP IS LEFT CENTER. THE PROCESSING PLANT AND TIPPLE ARE RIGHT CENTER. - Smith Mine, Bear Creek 1.5 miles West of Town of Bear Creek, Red Lodge, Carbon County, MT

  6. Smith et al. Patterns of diversification in Yucca Electronic Supplementary Material Electronic Supplementary Materials

    E-print Network

    Althoff, David M.

    Smith et al. Patterns of diversification in Yucca Electronic Supplementary Material Electronic as ordered, multi-state characters. #12;Smith et al. Patterns of diversification in Yucca Electronic of the organisms. Within Yuccas, it has been suggested that occasional introgression of chloroplast genomes between

  7. VIEW OF H.M. CAMP SMITH RECREATIONAL AREA, WITH MANANA HOUSING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF H.M. CAMP SMITH RECREATIONAL AREA, WITH MANANA HOUSING AREA IN THE FAR LEFT DISTANCE. VIEW FACING EAST - Camp H.M. Smith and Navy Public Works Center Manana Title VII (Capehart) Housing, Intersection of Acacia Road and Brich Circle, Pearl City, Honolulu County, HI

  8. 78 FR 15747 - Charlissa C. Smith (Denial of Senior Reactor Operator License)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-12

    ... COMMISSION Charlissa C. Smith (Denial of Senior Reactor Operator License) Notice of Atomic Safety and Licensing Board Reconstitution Pursuant to 10 CFR 2.313(c) and 2.321(b), the Atomic Safety and Licensing Board (Board) in the above-captioned Charlissa C. Smith case is hereby reconstituted...

  9. From Nash and Brown to Maynard Smith: Equilibria, Dynamics, and ESS

    E-print Network

    Hofbauer, Josef

    From Nash and Brown to Maynard Smith: Equilibria, Dynamics, and ESS Josef Hofbauer Institut f (equivalent to Brown's #12;ctitious play), the smoothed best response dynamics, and the Brown{von Neumann{88, and is dedicated to John Maynard Smith at the occasion of his 80th birthday. It follows a lecture delivered

  10. Rhetorical Studies: A Reassessment of Adam Smith's Lectures on Rhetoric and Belles Lettres.

    ERIC Educational Resources Information Center

    Purcell, William M.

    1986-01-01

    Offers a dissenting interpretation of Adam Smith's Lectures on Rhetoric and Belles Lettres and a more conservative perspective on Smith's significance to the history of rhetorical theory. Views the lectures as an historical commentary on literature and rhetoric from the perspective of an eighteenth-century lecturer. (JD)

  11. The Robert H. Smith Faculty of Agriculture, Food & Environment The Division for External Studies

    E-print Network

    Nathan, Ran

    The Robert H. Smith Faculty of Agriculture, Food & Environment The Division for External Studies Ronnie Katzir, International M.Sc. Programs Website: http://departments.agri to the age of 35, for a one or two year master's degree at the Robert H. Smith Faculty of Agriculture, Food

  12. 77 FR 12324 - Captain John Smith Chesapeake National Historic Trail Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-29

    ... National Park Service Captain John Smith Chesapeake National Historic Trail Advisory Council AGENCY... Captain John Smith Chesapeake National Historic Trail will hold a meeting. Designated through an amendment..., Maryland, Delaware, and in the District of Columbia,'' tracing the 1607-1609 voyages of Captain John...

  13. 76 FR 26767 - Captain John Smith Chesapeake National Historic Trail Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-09

    ... National Park Service Captain John Smith Chesapeake National Historic Trail Advisory Council AGENCY... Captain John Smith Chesapeake National Historic Trail will hold a meeting. Designated through an amendment..., Maryland, Delaware, and in the District of Columbia,'' tracing the 1607-1609 voyages of Captain John...

  14. 76 FR 52691 - Captain John Smith Chesapeake National Historic Trail Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-23

    ... National Park Service Captain John Smith Chesapeake National Historic Trail Advisory Council AGENCY... Captain John Smith Chesapeake National Historic Trail will hold a meeting. Designated through an amendment..., Maryland, Delaware, and in the District of Columbia,'' tracing the 1607-1609 voyages of Captain John...

  15. 77 FR 23658 - Six Rivers National Forest, Gasquet Ranger District, California, The Smith River National...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-20

    ... Smith River National Recreation Area Restoration and Motorized Travel Management Project AGENCY: Forest.... This project responds to the Travel Management Rule, Subpart B (36 CFR 212.52), which requires the...-pacificsouthwest-six-rivers@fs.fed.us . Please insure that ``Smith River NRA Restoration and Motorized...

  16. 78 FR 6173 - Diana Del Grosso, Ray Smith, Joseph Hatch, Cheryl Hatch, Kathleen Kelley, Andrew Wilklund, and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-29

    ...Transportation Board [Docket No. FD 35652] Diana Del Grosso, Ray Smith, Joseph Hatch, Cheryl Hatch, Kathleen Kelley, Andrew...to a petition filed on August 1, 2012, by Diana Del Grosso, Ray Smith, Joseph Hatch, Cheryl Hatch, Kathleen Kelley,...

  17. The Relation of Recruitment Rate to Activity Rhythms in the Harvester Ant, Pogonomyrmex barbatus (F. Smith) (Hymenoptera: Formicidae)

    E-print Network

    Gordon, Deborah

    . Smith) (Hymenoptera: Formicidae) Author(s): Deborah M. Gordon Reviewed work(s): Source: Journal Rhythms in the Harvester Ant, Pogonomyrmex barbatus (F. Smith) (Hymenoptera: Formicidae) Deborah M. Gordon

  18. Irish Astr. J., 27(1), XXXX, (2000) M. D. SMITH EVOLUTIONARY SCHEMES FOR PROTOSTARS, PROTO BROWN DWARFS

    E-print Network

    2000-01-01

    Irish Astr. J., 27(1), XXXX, (2000) M. D. SMITH EVOLUTIONARY SCHEMES FOR PROTOSTARS, PROTO BROWN DWARFS AND THEIR ENVIRONMENTS M. D. SMITH Armagh Observatory, College Hill, Armagh, N. Ireland, BT61 9DG

  19. A Banded Smith-Waterman FPGA Accelerator for Mercury Brandon Harris, Arpith C. Jacob, Joseph M. Lancaster,

    E-print Network

    Chamberlain, Roger

    A Banded Smith-Waterman FPGA Accelerator for Mercury BLASTP Brandon Harris, Arpith C. Jacob, Joseph. Lancaster, Jeremy Buhler, and Roger D. Chamberlain, "A Banded Smith-Waterman FPGA Accelerator for Mercury SMITH-WATERMAN FPGA ACCELERATOR FOR MERCURY BLASTP Brandon Harris* , Arpith C. Jacob*, Joseph M

  20. 75 FR 68401 - Duncan Smith and Gerald Altizer-Continuance in Control Exemption-Eighteen Thirty Group, LLC and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-05

    ...Docket No. FD 35436] Duncan Smith and Gerald Altizer--Continuance...Georges Creek Railway, LLC Duncan Smith and Gerald Altizer (collectively...Class III rail carriers. Mr. Smith owns 80% of Eighteen Thirty...in Georges Creek is owned by Patrick...

  1. 77 FR 30047 - Notice of Opportunity for Public Comment on Surplus Property Release at Michael J Smith Field...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-21

    ...Comment on Surplus Property Release at Michael J Smith Field, Beaufort, NC AGENCY: Federal...airport property, located at the Michael J Smith Field, be used for aeronautical purposes...acres of airport property at the Michael J Smith Field. The property consists of...

  2. Enzymatic Ligation Reactions of DNA "Words" on Surfaces for DNA Anthony G. Frutos, Lloyd M. Smith, and Robert M. Corn*

    E-print Network

    M. Smith, and Robert M. Corn* Contribution from the Department of Chemistry, Uni, L. M.; Corn, R. M. Nucleic Acids Res. 1997, 25, 4748-4757. (4) Smith, L. M.; Corn, R. M.; Condon, A, Q.; Frutos, A. G.; Thiel, A. J.; Corn, R. M.; Smith, L. M. J. Comput. Biol. 1998, 5, 269-278. (6

  3. Obituary: Harding Eugene (Gene) Smith, Jr., 1947-2007

    NASA Astrophysics Data System (ADS)

    Lonsdale, Carol; Soifer, Tom

    2009-01-01

    Harding Eugene Smith Junior, or Gene, as he was known to family, friends, and colleagues, passed away after an automobile accident in Encinitas, California, on 16 August 2007. He was 60 years old. Gene had recently retired from UCSD after thirty years of service. A memorial service was held at Quail Botanical Gardens in Encinitas, California, on 23 August 2007. A web page is dedicated to his memory at http://harding.smith.muchloved.com, where contributions of memories are invited. Gene was born in San Jose, California in 1947, to Harding Eugene Smith Senior, and Bernice Smith (nee Smith). Harding Smith Senior was an air-force navigator; therefore Gene spent his childhood moving from one air-force base to another. Although an only child, Gene was very close to his cousin Meg, whom he lived nearby to in Gilroy for a time, and the two were like brother and sister. The elder Harding Smith was lost in action over Cambodia in the mid-sixties. Gene was a dedicated student, a boy scout, and a Presidential Scholar. He majored in Physics at Caltech, where he also took a lively interest in the football team and the Glee Club, and was elected a House Officer. To his close friends, he was known at Caltech as Smitty, and the closest of them was Rob Drew, who gave a glimpse into that period of Gene's life at the memorial: "Gene arrived early at campus his first year, in response to an invitation to join the football team. Gene's size and features reminded the head coach of a long-forgotten player named 'Johnson.' After a few days of confusion, Gene simply replaced the name on his helmet. 'Johnson!' coach would yell, 'get in there!' If Johnson was going to get to play, Gene was going to be the best Johnson available!" Gene spent the summer of 1966 working at Kitt Peak, where his lifetime love of observing with ground-based telescopes began, though he learned some things the hard way, such as the fact that trying to squeeze 40,000 numbers onto a computer that stored only 32,000 resulted in blown fuses. In a final letter of that summer back to Drew he wrote: "My summer is now complete. I have achieved the highest pinnacle in my quest for fulfillment. Striking a blow for humanity I just blew the whole Kitt Peak CDC3200 computer system. Those fuses were nothing compared to this!" Gene's graduate work, on the metal abundances in HII regions of nearby galaxies, was done at Berkeley, where Hyron Spinrad was his thesis advisor. He loved observing and spent numerous fun nights at Lick, Kitt Peak, Cerro Tololo, Keck, and many other observatories. He joined Margaret Burbidge at UCSD for a postdoctoral fellowship, and joined the teaching faculty there in 1978. Gene spent his entire professional career at UCSD. His research ranged from the study of quasar absorptions lines to the astrophysics of Ultra-luminous Infrared Galaxies. He was a key participant in UC-wide astronomy support, including being the chair of the science-advisory committee for the Ten Meter Telescope project, which later "morphed" into the Keck Observatory. His contributions to enabling that project were both essential and unheralded. Gene was a dedicated and enthusiastic teacher. One of his favorite undergraduate classes gave him the opportunity to dress up in Renaissance garb and pretend to be Galileo, while the experiment most loved by his students was when they got to attempt to drop an egg on his head from several stories high. Gene was also an outstanding advisor and mentor, and both his first post-doc, Rick Puetter, and his last graduate student, Brian Siana, were able to attend his memorial service and provide some special memories of their experiences with him. Rick recalled a memorable trip to Cerro Tololo when they packed up two infrared spectrometers for the trip, and everything conceivable went wrong, from inspections at the airport to spectrometer parts broken on the plane and instrument failures at the observatory, to finally being completely clouded out. Brian recounted: "I spent countless cloudy nights listening to Gene's stories

  4. Growth charts for individuals with Smith-Lemli-Opitz syndrome.

    PubMed

    Lee, Ryan W Y; McGready, John; Conley, Sandra K; Yanjanin, Nicole M; Nowaczyk, Ma?gorzata J M; Porter, Forbes D

    2012-11-01

    Smith-Lemli-Opitz syndrome (SLOS) is a rare multiple congenital anomaly neurodevelopmental syndrome of impaired cholesterol synthesis. Growth restriction and developmental delay are very common clinical manifestations of SLOS. The degree, etiology, and consequences of growth restriction in SLOS remain an area of limited knowledge to the scientific community. There have been no studies describing the growth parameters and providing reference growth charts for individuals with SLOS. Our longitudinal data from 78 patients between the ages of 0.1 and 16 years with SLOS show a growth restriction of about two standard deviations below the Centers for Disease Control (CDC) norms for age. This study represents comprehensive anthropometric data from the largest cohort available, and proposes growth charts for widespread use in the management and study of individuals with SLOS. PMID:22615010

  5. Smith/Birnstiel mapping of genome rearrangements in Pseudomonas aeruginosa.

    PubMed

    Heuer, T; Bürger, C; Tümmler, B

    1998-04-01

    A novel application of the Smith/Birnstiel technique is presented for the analysis of intraspecies genomic diversity in small genomes. Rare-cutter total/N frequent-cutter partial restriction digestions are separated in N separate lanes by pulsed-field gel electrophoresis, blotted and hybridized with rare-cutter fragment ends as probes. The evaluation of the autoradiogram results in high-resolution restriction maps of 10-200 kbp regions. The technique was applied to the analysis of genome rearrangements in Pseudomonas aeruginosa strains. Comparison of the region encoding the tryptophan biosynthesis genes in the PAO and the IATS serotype 5 strains revealed that shared sequence characterized by almost identical restriction fingerprints was interrupted in the serotype 5 strain by small islands displaying strain-specific restriction site signatures. A multistep rearrangement in a hypervariable chromosome region downstream of the phn locus was detected in serial airway isolates from a patient with cystic fibrosis. PMID:9588793

  6. Smith college secondary math and science outreach program

    SciTech Connect

    Powell, J.A.; Clark, C.

    1994-12-31

    The Smith College Secondary Math and Science Outreach Program works collaboratively with front-line educators to encourage young women students of all abilities, especially underrepresented and underserved minorities, to continue studying math and science throughout high school. The program includes three main components: (1) Twenty-five to thirty teams of math/science teachers and guidance counselors participate in a year-long program which begins with a three-day Current Students/Future Scientists and Engineering Workshop. This event includes a keynote address, presentations and workshops by successful women in science and engineering, and hands-on laboratory sessions. Each participant receives a stipend and free room and board. Returning to their schools, the teacher-counselor teams implement ongoing plans designed to counteract gender bias in the sciences and to alert female students to the broad range of math, science, and engineering career choices open to them. A follow-up session in the spring allows the teams to present and discuss their year-long activities. (2) TRI-ON, a day of science for 120 ninth- and tenth- grade girls from schools with a large underserved and underrepresented population, is held in early spring. Girls discover the excitement of laboratory investigation and interact with female college science and math majors. (3) Teaching Internships, initiated in 1991, involve ten to fifteen Smith College math and science majors in teaching in public schools. The teaching interns experience the rewards and challenges of classroom teaching, and they also serve as role models for younger students.

  7. Comments on the "Proof of the atmospheric greenhouse effect" by Arthur B. Smith

    E-print Network

    Kramm, Gerhard; Zelger, Michael

    2009-01-01

    In this paper it is shown that Smith (2008) used inappropriate and inconsistent formulations in averaging various quantities over the entire surface of the Earth considered as a sphere. Using two instances of averaging procedures as customarily applied in studies on turbulence, it is shown that Smith's formulations are highly awkward. Furthermore, Smith's discussion of the infrared absorption in the atmosphere is scrutinized and evaluated. It is shown that his attempt to refute the criticism of Gerlich and Tscheuschner (2007, 2009) on the so-called greenhouse effect is rather fruitless.

  8. A local construction of the Smith normal form of a matrix polynomial

    SciTech Connect

    Wilkening, Jon; Yu, Jia

    2008-09-01

    We present an algorithm for computing a Smith form with multipliers of a regular matrix polynomial over a field. This algorithm differs from previous ones in that it computes a local Smith form for each irreducible factor in the determinant separately and then combines them into a global Smith form, whereas other algorithms apply a sequence of unimodular operations to the original matrix row by row (or column by column). The performance of the algorithm in exact arithmetic is reported for several test cases.

  9. Birth of the Canadian Digestive Health Foundation.

    PubMed

    Beck, Ivan T

    2004-01-01

    The Canadian Digestive Disease Foundation, renamed the Canadian Digestive Health Foundation--Fondation canadienne pour la promotion de la santé digestive--in December 2001, is the culmination of ongoing efforts by the Canadian Association of Gastroenterology to establish an independent charitable organization. In February 2001, it was officially endorsed as the Foundation for the Canadian Association of Gastroenterology. The initial efforts to establish this Foundation, led by Dr Richard McKenna in 1963, were unsuccessful. In 1991, Glaxo Canada (now GlaxoSmithKline) became a founding donor, and with the four founding physicians--Drs Ivan T Beck, Richard H Hunt, Suzanne E Lemire and Alan BR Thomson--the expenses to establish the Foundation were met. A charitable number was obtained in 1995 (0997427-11). The second founding donor was Janssen Canada (now Janssen-Ortho), and public education support came from Astra Canada (now AstraZeneca Canada). The Foundation initially relied on corporate donors, but now approaches physicians, patients and the general public. The objectives of the Foundation are to advance the science of gastroenterology and to provide knowledge of digestive diseases and nutrition to the general public, to enhance the quality of life of persons who are afflicted with these disorders. The major achievements of the Foundation are the provision of one-year operating grants to new investigators, which have allowed them to accumulate early data and subsequently obtain support from other major granting organizations. It also provides Fellowships and studentship support grants, in conjunction with the Canadian Institutes of Health Research and the pharmaceutical industry. The education committee found that there was little research support in this field, considering the large economic burden of digestive disease and the amount of outstanding work done by Canadian researchers. A bilingual Web site, a web-based specialist's discussion program and bilingual pamphlets facilitate public awareness and allow patients to voice concerns. PMID:14760429

  10. Sliding Mode Control Design for Hysteretic Ferroelectric Jerry A. McMahan and Ralph C. Smith

    E-print Network

    . Smith Department of Mathematics Center for Research in Scientific Computation North Carolina State. Using a recently developed modification to the homogenized energy model for ferroelectric materials, we is to apply inverse compensation methods to approximately cancel the hysteretic nonlinearities, resulting

  11. Camp H.M. Smith and Navy Public Works Center Manana Title ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Camp H.M. Smith and Navy Public Works Center Manana Title VII (Capehart) Housing, Three-Bedroom Single-Family Type 9, Birch Circle, Elm Drive, Elm Circle, and Date Drive, Pearl City, Honolulu County, HI

  12. George E. KidderSmith, photographer, April 1945, Photograph #1101. VIEW OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    George E. Kidder-Smith, photographer, April 1945, Photograph #110-1. VIEW OF BUILDING 23, SOUTH SIDE WITH ARCADE, FACING NORTHWEST - Roosevelt Base, Auditorium-Gymnasium, West Virginia Street between Richardson & Reeves Avenues, Long Beach, Los Angeles County, CA

  13. George E. KidderSmith, April 1945, Photograph #1338. VIEW OF BUILDING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    George E. Kidder-Smith, April 1945, Photograph #133-8. VIEW OF BUILDING 23, FRONT SIDE FROM ACROSS COURTYARD, FACING WEST - Roosevelt Base, Auditorium-Gymnasium, West Virginia Street between Richardson & Reeves Avenues, Long Beach, Los Angeles County, CA

  14. The Library of Maynard-Smith: My Search for Meaning in the Protein

    E-print Network

    Arnold, Frances H.

    glorious creatures Mendel's library contains! But the vast majority of possible genomes does not encode in a hope- less search for these magnificent, but extremely rare books? Maynard-Smith's library is different

  15. Francis H. Smith: architect of antebellum southern military schools and educational reform 

    E-print Network

    Wineman, Bradford Alexander

    2006-10-30

    This study examines the historical significance of the Virginia Military Institute�s (VMI) first superintendent, Francis Henney Smith, and his influence not only at his home institution but also on his broader social, educational, and political...

  16. The where's and when's of kinase F. Donelson Smith, Lorene K. Langeberg and John D. Scott

    E-print Network

    Scott, John D.

    The where's and when's of kinase anchoring F. Donelson Smith, Lorene K. Langeberg and John D. Scott-workers [3], the identification of Src tyrosine kinase by Brugge and Ericsson et al. [4], the seminal work

  17. 77 FR 64411 - Safety Zone; Cooper T. Smith Fireworks Event; Mobile River; Mobile, AL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-22

    ...1625-AA00 Safety Zone; Cooper T. Smith Fireworks Event; Mobile River; Mobile, AL AGENCY: Coast Guard, DHS. [[Page 64412...establishing a temporary safety zone for a portion of the Mobile River, Mobile, AL in the vicinity of Cooper...

  18. Adam Smith's rhetorical sympathy: a return of moral sentiments to public policy 

    E-print Network

    Gore, David Charles

    2001-01-01

    Since Adam Smith's highly successful Wealth of Nations, most scholarship built on his work has been economic in scope and has ignored the greater implications of his contribution to policy-making. This thesis examines the role moral sentiment...

  19. Tianxing Cai, Visiting Assistant Professor Dan F. Smith Department of Chemical Engineering

    E-print Network

    Guo, John Zhanhu

    Tianxing Cai, Visiting Assistant Professor Dan F. Smith Department of Chemical Engineering Lamar, Texas Chemical Engineering Ph.D., 2014 B. Professional Experience 2015 ­ Present Visiting Assistant., "Coupling Multiple Water-reuse Network Designs for Agile Manufacturing", Computers & Chemical Engineering

  20. Camp H.M. Smith and Navy Public Works Center Manana Title ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Camp H.M. Smith and Navy Public Works Center Manana Title VII (Capehart) Housing, Three-Bedroom Single-Family Types 8 and 11, Birch Circle, Elm Drive, Elm Circle, and Date Drive, Pearl City, Honolulu County, HI

  1. Camp H.M. Smith and Navy Public Works Center Manana Title ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Camp H.M. Smith and Navy Public Works Center Manana Title VII (Capehart) Housing, U-Shaped Two-Bedroom Single-Family Type 6, Birch Circle, Elm Drive, Elm Circle, and Date Drive, Pearl City, Honolulu County, HI

  2. Camp H.M. Smith and Navy Public Works Center Manana Title ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Camp H.M. Smith and Navy Public Works Center Manana Title VII (Capehart) Housing, Three-Bedroom Single-Family Type 7, Birch Circle, Elm Drive, Elm Circle, and Date Drive, Pearl City, Honolulu County, HI

  3. Camp H.M. Smith and Navy Public Works Center Manana Title ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Camp H.M. Smith and Navy Public Works Center Manana Title VII (Capehart) Housing, Four-Bedroom, Single-Family Type 10, Birch Circle, Elm Drive, Elm Circle, and Date Drive, Pearl City, Honolulu County, HI

  4. Camp H.M. Smith and Navy Public Works Center Manana Title ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Camp H.M. Smith and Navy Public Works Center Manana Title VII (Capehart) Housing, U-Shaped Three-Bedroom Duplex Type 4, Acacia Road, Birch Circle, Cedar Drive and Elm Drive, Pearl City, Honolulu County, HI

  5. University of California: In Memoriam, 1959 Page 1 of 2 Harry Scott Smith, Biological Control: Riverside

    E-print Network

    Hoddle, Mark S.

    Smith died suddenly at his home in Riverside on Thanksgiving Day. He went the way he had expressed of Expert. His first assignment was a study of the parasites of the boll weevil in the southern states

  6. Measuring short electron bunch lengths using coherent Smith-Purcell radiation

    DOEpatents

    Nguyen, D.C.

    1999-03-30

    A method is provided for directly determining the length of sub-picosecond electron bunches. A metallic grating is formed with a groove spacing greater than a length expected for the electron bunches. The electron bunches are passed over the metallic grating to generate coherent and incoherent Smith-Purcell radiation. The angular distribution of the coherent Smith-Purcell radiation is then mapped to directly deduce the length of the electron bunches. 8 figs.

  7. Measuring short electron bunch lengths using coherent smith-purcell radiation

    DOEpatents

    Nguyen, Dinh C. (Los Alamos, NM)

    1999-01-01

    A method is provided for directly determining the length of sub-picosecond electron bunches. A metallic grating is formed with a groove spacing greater than a length expected for the electron bunches. The electron bunches are passed over the metallic grating to generate coherent and incoherent Smith-Purcell radiation. The angular distribution of the coherent Smith-Purcell radiation is then mapped to directly deduce the length of the electron bunches.

  8. Peroxisomal cholesterol biosynthesis and Smith-Lemli-Opitz syndrome

    SciTech Connect

    Weinhofer, Isabelle; Kunze, Markus; Stangl, Herbert; Porter, Forbes D.; Berger, Johannes . E-mail: johannes.berger@meduniwien.ac.at

    2006-06-23

    Smith-Lemli-Opitz syndrome (SLOS), caused by 7-dehydrocholesterol-reductase (DHCR7) deficiency, shows variable severity independent of DHCR7 genotype. To test whether peroxisomes are involved in alternative cholesterol synthesis, we used [1-{sup 14}C]C24:0 for peroxisomal {beta}-oxidation to generate [1-{sup 14}C]acetyl-CoA as cholesterol precursor inside peroxisomes. The HMG-CoA reductase inhibitor lovastatin suppressed cholesterol synthesis from [2-{sup 14}C]acetate and [1-{sup 14}C]C8:0 but not from [1-{sup 14}C]C24:0, implicating a peroxisomal, lovastatin-resistant HMG-CoA reductase. In SLOS fibroblasts lacking DHCR7 activity, no cholesterol was formed from [1-{sup 14}C]C24:0-derived [1-{sup 14}C]acetyl-CoA, indicating that the alternative peroxisomal pathway also requires this enzyme. Our results implicate peroxisomes in cholesterol biosynthesis but provide no link to phenotypic variation in SLOS.

  9. Smith River Rancheria's Development of an Energy Organization Investigation

    SciTech Connect

    W.G Buehler & Associates

    2007-08-27

    Smith River Rancheria (SRR), for some time, has had a strong commitment to attaining energy selfsufficiency, to reduce overall energy costs and concurrently initiate economic development within the community. Early on it was recognized that the development of an energy organization was important and for this reason was made part of the SRR's strategic review not only for economic development but also the reduction of energy costs. Towards this end, SRR retained Werner G. Buehler of W.G. Buehler & Associates to investigate the many phases or steps required to establish such an energy organization and determine, if in fact, it could benefit the Tribe. The basic phases are delineated as: (1) Identify potential sources of wholesale power and transmission paths; (2) Evaluating the various forms of energy organizations; (3) Determining the benefits (and disadvantages) of each form of organization; (4) Gathering costs to organize and operate the selected form or energy organization; (5) Performing an economic analysis of forming and operating an energy organization; and (6) Develop an implementation plan.

  10. Epidemiologic classics of Carter, Maxcy, Trudeau, and Smith.

    PubMed

    Woodward, T E

    1992-02-01

    Four great epidemiologists whose work so concisely linked clinical observations, epidemiologic clues, and logical preventive measures are discussed. Henry Rose Carter set the stage for the Walter Reed successes in Cuba by showing that 9-16 days must elapse after contact before yellow fever develops. This provided the link for the Reed group to allow the "virus" to incubate in the mosquito before becoming infectious. Kenneth Maxcy clarified the controversy between endemic typhus fever and Brill's disease in the southeastern United States. His clinical, epidemiologic, and laboratory findings led him to propose that the causative organism (Rickettsia typhi) was in rodents and the probable vector, fleas. When confirmed, effective control measures were applied. Two other American investigators, Edward L. Trudeau and Theobald Smith, helped prove Robert Koch wrong on three counts: (1) Tuberculin is not an effective therapeutic agent for tuberculosis; (2) there are two distinct types of tubercle bacillus, human and bovine; and (3) the bovine form of Mycobacterium tuberculosis is remarkably pathogenic for humans. The significance of these findings is unlimited. PMID:1730891

  11. Mechanisms of Acquired Resistance to Tyrosine Kinase Inhibitors in Clear - Cell Renal Cell Carcinoma (ccRCC)

    PubMed Central

    Bielecka, Zofia F; Czarnecka, Anna M; Solarek, Wojciech; Kornakiewicz, Anna; Szczylik, Cezary

    2013-01-01

    Clear - cell renal cell carcinoma (ccRCC) is a histological subtype of renal cell carcinoma - the most prevalent adult kidney cancer. Causes of ccRCC are not completely understood and therefore number of available therapies is limited. As a consequence of tumor chemo- and radioresistance as well as restrictions in offered targeted therapies, overall response rate is still unsatisfactory. Moreover, a significant group of patients (circa 1/4) does not respond to the targeted first-line treatment, while in other cases, after an initial period of stable improvement, disease progression occurs. Owing to this, more data on resistance mechanisms are needed, especially those concerning widely used, relatively lately approved and more successful than previous therapies - tyrosine kinase inhibitors (TKIs). Up to date, five TKIs have been licensed for ccRCC treatment: sunitinib (SUTENT®, Pfizer Inc.), sorafenib (Nexavar®, Bayer HealthCare/Onyx Pharmaceuticals), pazopanib (Votrient®, GlaxoSmithKline), axitinib (Inlyta®, Pfitzer Inc.) and tivozanib (AV-951®, AVEO Pharmaceuticals). Researchers have specified different subsets of tyrosine kinase inhibitors potential resistance mechanisms in clear-cell renal cell carcinoma. In most papers published until now, drug resistance is divided into intrinsic and acquired, and typically multi-drug resistance (MDR) protein is described. Herein, the authors focus on molecular analysis concerning acquired, non-genetic resistance to TKIs, with insight into specific biological processes. PMID:25152704

  12. Young people's comparative recognition and recall of an Australian Government Sexual Health Campaign.

    PubMed

    Lim, Megan S C; Gold, Judy; Bowring, Anna L; Pedrana, Alisa E; Hellard, Margaret E

    2015-05-01

    In 2009, the Australian Government's National Sexually Transmitted Infection Prevention Program launched a multi-million dollar sexual health campaign targeting young people. We assessed campaign recognition among a community sample of young people. Individuals aged 16-29 years self-completed a questionnaire at a music festival. Participants were asked whether they recognised the campaign image and attempted to match the correct campaign message. Recognition of two concurrent campaigns, GlaxoSmithKline's The Facts genital herpes campaign (targeting young women) and the Drama Downunder campaign (targeting gay men) were assessed simultaneously. Among 471 participants, just 29% recognised the National Sexually Transmitted Infection Prevention Program campaign. This compared to 52% recognising The Facts and 27% recognising Drama Downunder. Of 134 who recognised the National Sexually Transmitted Infection Prevention Program campaign, 27% correctly recalled the campaign messages compared to 61% of those recognising the Facts campaign, and 25% of those recognising the Drama Downunder campaign. There was no difference in National Sexually Transmitted Infection Prevention Program campaign recognition by gender or age. Campaign recognition and message recall of the National Sexually Transmitted Infection Prevention Program campaign was comparatively low. Future mass media sexual health campaigns targeting young people can aim for higher recognition and recall rates than that achieved by the National Sexually Transmitted Infection Prevention Program campaign. Alternative distribution channels and message styles should be considered to increase these rates. PMID:25006041

  13. Thousands of chemical starting points for antimalarial lead identification.

    PubMed

    Gamo, Francisco-Javier; Sanz, Laura M; Vidal, Jaume; de Cozar, Cristina; Alvarez, Emilio; Lavandera, Jose-Luis; Vanderwall, Dana E; Green, Darren V S; Kumar, Vinod; Hasan, Samiul; Brown, James R; Peishoff, Catherine E; Cardon, Lon R; Garcia-Bustos, Jose F

    2010-05-20

    Malaria is a devastating infection caused by protozoa of the genus Plasmodium. Drug resistance is widespread, no new chemical class of antimalarials has been introduced into clinical practice since 1996 and there is a recent rise of parasite strains with reduced sensitivity to the newest drugs. We screened nearly 2 million compounds in GlaxoSmithKline's chemical library for inhibitors of P. falciparum, of which 13,533 were confirmed to inhibit parasite growth by at least 80% at 2 microM concentration. More than 8,000 also showed potent activity against the multidrug resistant strain Dd2. Most (82%) compounds originate from internal company projects and are new to the malaria community. Analyses using historic assay data suggest several novel mechanisms of antimalarial action, such as inhibition of protein kinases and host-pathogen interaction related targets. Chemical structures and associated data are hereby made public to encourage additional drug lead identification efforts and further research into this disease. PMID:20485427

  14. Pharma TARP: a troubled asset relief program for novel, abandoned projects in the pharmaceutical industry.

    PubMed

    Bartfai, Tamas; Lees, Graham Vaughan

    2011-01-01

    Within days of each other, Pfizer, Merck, and GlaxoSmithKline announced that they will focus on a few therapeutic areas only and abandon others entirely. Pfizer alone will close well over a hundred drug development projects that have reached two-thirds of the way to launch. The programs are deemed to be too risky and not lucrative enough for Big Pharma in the current climate. Society has a real need for the drugs that are no longer going to be developed for, among others, drug-resistant epilepsy, neuropathic and cancer pain, type-2 diabetes, obesity, and schizophrenia. The authors propose a radical response by the U.S. government and the National Institutes of Health to rescue these abandoned projects, and to continue selected programs for drug approval by the U.S. Food and Drug Administration and the European Medicines Agency. The investment required is small compared to the Troubled Asset Relief Program bank bail out, but the return on investment in financial terms and in satisfying societal needs makes this proposal attractive. PMID:21336460

  15. Performance of rotavirus vaccines in developed and developing countries

    PubMed Central

    Jiang, Victoria; Jiang, Baoming; Tate, Jacqueline; Parashar, Umesh D

    2010-01-01

    The World Health Organization estimates that rotavirus diarrhea results in approximately half a million deaths and approximately 2.4 million hospitalizations in developing countries each year. Two live oral rotavirus vaccines, RotaTeq® (RV 5; Merck) and Rotarix® (RV 1; GlaxoSmithKline) with good efficacy against severe rotavirus disease and a reassuring safety profile could substantially impact the burden of rotavirus disease. In April 2009, WHO provided a recommendation for global introduction of these vaccines in national immunization programs of developing countries worldwide. In this article, we review published data on previous candidate rotavirus vaccines and vaccines in current use, with emphasis on their performance in developed versus developing countries. In developed countries, both first and second generation rotavirus vaccines have demonstrated high efficacy against severe rotavirus disease (pooled efficacy = 73% and 85%, respectively). In developing countries, small early trials for the first generation vaccines failed to provide protection against rotavirus disease (pooled efficacy = 20%), however, trials of the second generation vaccines yielded substantial improvements in efficacy in developing countries (pooled efficacy of 51%), leading to a global recommendation for rotavirus vaccine introduction by WHO. Future efforts for these vaccines should focus on optimizing the efficacy and delivery of these vaccines in challenging target populations of Asia and Africa with the greatest burden of severe rotavirus disease. PMID:20622508

  16. A malaria vaccine for travelers and military personnel: Requirements and top candidates.

    PubMed

    Teneza-Mora, Nimfa; Lumsden, Joanne; Villasante, Eileen

    2015-12-22

    Malaria remains an important health threat to non-immune travelers with the explosive growth of global travel. Populations at high risk of acquiring malaria infections include once semi-immune travelers who visit friends and relatives, military forces, business travelers and international tourists with destinations to sub-Saharan Africa, where malaria transmission intensity is high. Most malaria cases have been associated with poor compliance with existing preventive measures, including chemoprophylaxis. High risk groups would benefit immensely from an efficacious vaccine to protect them against malaria infection and together make up a sizable market for such a vaccine. The attributes of an ideal malaria vaccine for non-immune travelers and military personnel include a protective efficacy of 80% or greater, durability for at least 6 months, an acceptable safety profile and compatibility with existing preventive measures. It is very likely that a malaria vaccine designed to effectively prevent infection and clinical disease in the non-immune traveler and military personnel will also protect semi-immune residents of malaria-endemic areas and contribute to malaria elimination by reducing or blocking malaria transmission. The RTS,S vaccine (GlaxoSmithKline) and the PfSPZ Vaccine (Sanaria Inc) are the leading products that would make excellent vaccine candidates for these vulnerable populations. PMID:26458800

  17. Ropinirole for the treatment of restless legs syndrome

    PubMed Central

    Kushida, Clete A

    2006-01-01

    Dopaminergic agents, anticonvulsants, benzodiazepines, opiates, and iron supplementation comprise the classes of medications commonly used to treat restless legs syndrome (RLS), which is a disorder that is estimated to affect about 1 in 10 individuals worldwide and impacts an affected patient’s sleep, mood, daytime function, and quality of life. RLS is characterized by an urge to move the legs that is worse at bedtime and at rest; the symptoms are temporarily relieved by leg movement. It is frequently accompanied by periodic limb movements during sleep (PLMS), which may independently disrupt sleep and may cause daytime drowsiness. Dopaminergic agents are considered to be first-line therapy in the management of RLS as well as PLMS. Ropinirole (Requip®, GlaxoSmithKline) is a dopamine agonist that was the first medication approved by the US Food and Drug Administration (FDA) for the treatment of moderate-to-severe primary RLS. Based on several large-scale clinical trials and open-label clinical series, this medication has been demonstrated to be effective and safe in treating the motor symptoms of RLS and improving sleep quality. PMID:19412490

  18. OOMMPPAA: A Tool To Aid Directed Synthesis by the Combined Analysis of Activity and Structural Data

    PubMed Central

    2014-01-01

    There is an ever increasing resource in terms of both structural information and activity data for many protein targets. In this paper we describe OOMMPPAA, a novel computational tool designed to inform compound design by combining such data. OOMMPPAA uses 3D matched molecular pairs to generate 3D ligand conformations. It then identifies pharmacophoric transformations between pairs of compounds and associates them with their relevant activity changes. OOMMPPAA presents this data in an interactive application providing the user with a visual summary of important interaction regions in the context of the binding site. We present validation of the tool using openly available data for CDK2 and a GlaxoSmithKline data set for a SAM-dependent methyl-transferase. We demonstrate OOMMPPAA’s application in optimizing both potency and cell permeability and use OOMMPPAA to highlight nuanced and cross-series SAR. OOMMPPAA is freely available to download at http://oommppaa.sgc.ox.ac.uk/OOMMPPAA/. PMID:25244105

  19. A randomized controlled trial of CBT therapy for adults with ADHD with and without medication

    PubMed Central

    2012-01-01

    Background Previous studies of psychological treatment in adults with ADHD have not controlled for medication status and include either medicated participants or mixed samples of medicated and unmedicated participants. The objective of this study is to examine whether use of medication improves outcome of therapy. Method This was a secondary analysis comparing 23 participants randomized to CBT and Dextroamphetamine vs. 25 participants randomized to CBT and placebo. Both patients and investigators were blind to treatment assignment. Two co-primary outcomes were used: ADHD symptoms on the ADHD-RS-Inv completed by the investigator and improvement in functioning as reported by the patient on the Sheehan Disability Scale. Results Both groups showed robust improvement in both symptoms and functioning, but the use of medication did not significantly improve outcome over and above use of CBT and placebo. Conclusion This study replicates previous work demonstrating that CBT is an effective treatment for ADHD in adults. Within the limits of this pilot, secondary analysis we were not able to demonstrate that medication significantly augments the outcome of CBT therapy for adults with ADHD. The study was funded by GlaxoSmithKline, Clinical Trials Registry #GSK707. PMID:22480189

  20. Use of MenACWY-CRM vaccine in children aged 2 through 23 months at increased risk for meningococcal disease: recommendations of the Advisory Committee on Immunization Practices, 2013.

    PubMed

    MacNeil, Jessica R; Rubin, Lorry; McNamara, Lucy; Briere, Elizabeth C; Clark, Thomas A; Cohn, Amanda C

    2014-06-20

    During its October 2013 meeting, the Advisory Committee on Immunization Practices (ACIP) recommended use of a third meningococcal conjugate vaccine, MenACWY-CRM (Menveo, Novartis), as an additional option for vaccinating infants aged 2 through 23 months at increased risk for meningococcal disease. MenACWY-CRM is the first quadrivalent meningococcal conjugate vaccine licensed for use in children aged 2 through 8 months. MenACWY-D (Menactra, Sanofi Pasteur) is recommended for use in children aged 9 through 23 months who are at increased risk for meningococcal disease, and Hib-MenCY-TT (MenHibrix, GlaxoSmithKline) is recommended for use in children aged 6 weeks through 18 months at increased risk. This report summarizes information on MenACWY-CRM administration in infants and provides recommendations for vaccine use in infants aged 2 through 23 months who are at increased risk for meningococcal disease. Because the burden of meningococcal disease in infants is low in the United States and the majority of cases that do occur are caused by serogroup B, which is not included in any vaccine licensed in the United States, only those infants who are at increased risk for meningococcal disease are recommended to receive a meningococcal vaccine. PMID:24941332

  1. Essential health care package for children--the 'Fit for School' program in the Philippines.

    PubMed

    Monse, Bella; Naliponguit, Ella; Belizario, Vincente; Benzian, Habib; van Helderman, Wim Palenstein

    2010-04-01

    High prevalence of poverty diseases such as diarrhoea, respiratory tract infection, parasitic infections and dental caries among children in the developing world calls for a return to primary health care principles with a focus on prevention. The 'Fit for School' program in the Philippines is based on international recommendations and offers a feasible, low-cost and realistic strategy using the principles of health promotion outlined in the Ottawa Charter. The cornerstone of the programme is the use of school structures for the implementation of preventive health strategies. 'Fit for School' consists of simple, evidence-based interventions like hand washing with soap, tooth brushing with fluoride toothpaste and other high impact interventions such as bi-annual de-worming as a routine school activity for all children visiting public elementary schools. The programme has been successfully rolled-out in the Philippines covering 630,000 children in 22 provinces and it is planned to reach 6 million children in the next three years. The programme is a partnership project between the Philippine Department of Education and the Local Government Units with support for capacity development activities from the German Development Cooperation and GlaxoSmithKline. PMID:20476713

  2. An analysis of the attrition of drug candidates from four major pharmaceutical companies.

    PubMed

    Waring, Michael J; Arrowsmith, John; Leach, Andrew R; Leeson, Paul D; Mandrell, Sam; Owen, Robert M; Pairaudeau, Garry; Pennie, William D; Pickett, Stephen D; Wang, Jibo; Wallace, Owen; Weir, Alex

    2015-07-01

    The pharmaceutical industry remains under huge pressure to address the high attrition rates in drug development. Attempts to reduce the number of efficacy- and safety-related failures by analysing possible links to the physicochemical properties of small-molecule drug candidates have been inconclusive because of the limited size of data sets from individual companies. Here, we describe the compilation and analysis of combined data on the attrition of drug candidates from AstraZeneca, Eli Lilly and Company, GlaxoSmithKline and Pfizer. The analysis reaffirms that control of physicochemical properties during compound optimization is beneficial in identifying compounds of candidate drug quality and indicates for the first time a link between the physicochemical properties of compounds and clinical failure due to safety issues. The results also suggest that further control of physicochemical properties is unlikely to have a significant effect on attrition rates and that additional work is required to address safety-related failures. Further cross-company collaborations will be crucial to future progress in this area. PMID:26091267

  3. Resource based view of the firm: measures of reputation among health service-sector businesses.

    PubMed

    Smith, Alan D

    2008-01-01

    Application of the strategic leverage of Resource Based View of the Firm (RBV) directly advocates that a company's competitive advantage is derived from its ability to assemble and exploit an appropriate combination of resources (both tangible and intangible assets). The three companies that were selected were Pittsburgh-based companies that were within relatively easy access, representing healthcare service-related industries, and can be reviewed for the principles of the RBV. The particular firms represented a variety of establishments and included Baptist Homes (a long-term care facility), University of Pittsburgh Medical Center (UPMC)(a provider of hospital and other health services), and GlaxoSmithKline, Consumer Healthcare, North America (GSK-CHNA)(a global provider of healthcare products and services). Through the case studies, it was found that not all intangible assets are strategic, and by extension, not all measures of reputation are strategic either. For an intangible asset to be considered strategic, in this case reputation, it must be valuable, rare, imperfectly imitable, and non-substitutable. PMID:19064477

  4. Fluticasone furoate/vilanterol combination for the treatment of COPD and asthma.

    PubMed

    Rogliani, P; Matera, M G; Cazzola, M

    2015-08-01

    The critical role of the combination therapy of an inhaled corticosteroid (ICS) and a long-acting ?-adrenoceptor agonist (LABA) in the treatment of patients suffering from asthma and also severe chronic obstructive pulmonary disease (COPD) patients with frequent exacerbations explains why there is a strong interest within the pharmaceutical industry in developing a once-daily ICS/LABA fixed-dose combination (FDC), in an attempt to simplify the treatment and, consequently, increase adherence to the prescribed therapy, and also to overcome the loss of patent protection. GlaxoSmithKline and Theravance have developed an inhaled FDC of the ICS fluticasone furoate (FF) and the LABA vilanterol (VI) as a once-daily treatment for asthma and COPD. FF/VI, by simplifying the dosing schedule, allows, for the first time, a shift from twice-daily to once-daily treatment, with an acceptable safety and tolerability profile that is consistent with the ICS/LABA class. The decision to prescribe FF/VI rather than another ICS/LABA FDC is likely to be based on the patient's preference for the inhaler device, their ability to use the device correctly and the convenience of once-daily dosing frequency as well as comparative costs with other combination products. However, further studies are required to specifically assess these possibilities. PMID:26380385

  5. Human papillomavirus and vaccination in cervical cancer.

    PubMed

    Wang, Kung-Liahng

    2007-12-01

    Cervical cancer is not only the most frequently reported cancer among women, but also the most common female genital tract neoplasm in Taiwan. Early detection is effective, because the development, maintenance and progression of precursor lesions (cervical intraepithelial neoplasia [CIN]) evolve slowly into invasive cancer, typically over a period of more than 10 years. It is now recognized that human papillomavirus (HPV) infection is a necessary cause for over 99% of cervical cancer cases. Advances in the understanding of the causative role of HPV in the etiology of high-grade cervical lesions (CIN 2/3) and cervical cancer have led to the development, evaluation and recommendation of HPV-based technologies for cervical cancer prevention and control. The prevention of HPV infection before the onset of CIN is now possible with recently available prophylactic HPV vaccines, e.g. the quadrivalent Gardasil (Merck & Co., NJ, USA) and bivalent Cervarix (GlaxoSmithKline, London, UK). This review article provides an up-to-date summary of recent studies and available information concerning HPV and vaccination in cervical cancer. PMID:18182340

  6. Measuring serum antibody to human papillomavirus following infection or vaccination.

    PubMed

    Frazer, Ian H

    2010-06-01

    The family of human papillomaviruses (HPVs) includes more than 130 genotypes, many of which infect the genital tract, and these can be classified as low risk or high risk for induction of genital neoplasia. Two prophylactic vaccines are currently available for the prevention of genital HPV infection: a quadrivalent (Gardasil); Merck & Co. Inc) and a bivalent (Cervarix; GlaxoSmithKline) vaccine. Protection against HPV infection and associated disease is observed for at least 6.4 years following immunization with the bivalent vaccine and for at least 8.5 years with the HPV 16L1 virus-like particle of the quadrivalent vaccine. HPV vaccines induce robust immune memory, as evidenced by recall of responses after revaccination, suggesting that immunization will afford long-lasting protection. An immunological marker for ongoing protection from infection would provide information to help establish best-practice deployment of these vaccines. However, while HPV-specific antibody is likely the major mechanism of protection against HPV infection following immunization, available serological assays provide only a partial characterization of immune status, and no measured immune response has been shown to define immediate or future protection against HPV infection or associated disease. Future research efforts should therefore be directed towards correlating measures of virus-specific immune memory with continued protection against infection with the HPV types in the available vaccines, and towards determining the duration of cross-protection afforded by these vaccines against HPV types other than those incorporated in the vaccines. PMID:20494221

  7. Virus-like particles in vaccine development.

    PubMed

    Roldão, António; Mellado, Maria Candida M; Castilho, Leda R; Carrondo, Manuel J T; Alves, Paula M

    2010-10-01

    Virus-like particles (VLPs) are multiprotein structures that mimic the organization and conformation of authentic native viruses but lack the viral genome, potentially yielding safer and cheaper vaccine candidates. A handful of prophylactic VLP-based vaccines is currently commercialized worldwide: GlaxoSmithKline's Engerix (hepatitis B virus) and Cervarix (human papillomavirus), and Merck and Co., Inc.'s Recombivax HB (hepatitis B virus) and Gardasil (human papillomavirus) are some examples. Other VLP-based vaccine candidates are in clinical trials or undergoing preclinical evaluation, such as, influenza virus, parvovirus, Norwalk and various chimeric VLPs. Many others are still restricted to small-scale fundamental research, despite their success in preclinical tests. This article focuses on the essential role of VLP technology in new-generation vaccines against prevalent and emergent diseases. The implications of large-scale VLP production are discussed in the context of process control, monitorization and optimization. The main up- and down-stream technical challenges are identified and discussed accordingly. Successful VLP-based vaccine blockbusters are briefly presented concomitantly with the latest results from clinical trials and the recent developments in chimeric VLP-based technology for either therapeutic or prophylactic vaccination. PMID:20923267

  8. Syncope after vaccination--United States, January 2005-July 2007.

    PubMed

    2008-05-01

    Syncope (vasovagal reaction), or fainting, can be triggered by various stimuli, including medical procedures. Syncope has been documented to occur after vaccination, most commonly among adolescents, and can result in hospitalization for a medical evaluation or because of injury. During 2005 and 2006, the Advisory Committee on Immunization Practices (ACIP) recommended use of three newly licensed vaccines for adolescents: the quadrivalent human papillomavirus recombinant vaccine (HPV) (Gardasil(R), Merck & Co., Inc., Whitehouse Station, New Jersey) in a 3-dose series, the quadrivalent meningococcal conjugate vaccine (MCV4) (Menactra, Sanofi Pasteur, Inc., Swiftwater, Pennsylvania) in a single dose, and the tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine (Tdap) (Adacel, Sanofi Pasteur; Boostrix, GlaxoSmithKline Biologicals, Research Triangle Park, North Carolina) in a single dose. To describe trends in occurrence of postvaccination syncope, CDC and the Food and Drug Administration (FDA) analyzed data from the Vaccine Adverse Event Reporting System (VAERS) for January 1, 2005-July 31, 2007, and compared the results with VAERS reports received during January 1, 2002-December 31, 2004. The findings indicated that, since 2005, reports to VAERS regarding postvaccination syncope have increased, primarily among females aged 11-18 years, and rarely, subsequent serious injuries have occurred. To prevent syncope-related injuries, vaccine providers should follow the ACIP recommendation to strongly consider observing patients for 15 minutes after vaccination. PMID:18451756

  9. [HPV vaccination: principles, results and future perspectives].

    PubMed

    Rouzier, R; Uzan, C; Collinet, P

    2007-02-01

    Human papillomavirus (HPV) are responsible of an important morbidity and mortality. HPV is a significant source of morbidity and mortality. HPV is the most common sexually transmitted infection: adolescents are at high-risk for HPV acquisition. Biologic and epidemiologic studies have demonstrated that HPV infection is a necessary but non-sufficient cause of cervical cancer and genital warts. The vast majority of cervical cancers contain high-risk HPV type and approximately 70% contain HPV types 16 or 18. HPV types 6 or 11 are responsible for approximately 90% of genital warts. Thus, a vaccine that could prevent. Prophylactic vaccines based on the use of virus-like particles (VLPs) obtained by auto-assembly of L1 are under clinical trials. Two vaccines are currently evaluated: Cervarix (GlaxoSmithKline Biologics), a bivalent vaccine against HPV 16 and 18, and Gardasil (Merck & Co) a quadrivalent vaccine against HPV 16, 18, 6, and 11. Phase I, II and III studies have demonstrated that both vaccines are well tolerated and provide an excellent immunogenicity. With approximately 5-year follow-up, both vaccines have been effective in preventing persistent infection with targeted HPV types and in preventing cervical intraepithelial lesions. The optimal target for vaccination is probably 12-year-old girls. PMID:17293248

  10. Straight talk with...Joseph Schwartz.

    PubMed

    Ratner, Mark

    2012-06-01

    On 17 May, Human Genome Sciences (HGS) formally rejected a $2.6 billion unsolicited takeover offer by GlaxoSmithKline. The Maryland-based biotech firm had long partnered with the UK drug giant to develop drugs including Benlysta (belimumab), HGS's first drug on the market and the first new medicine approved to fight lupus in 50 years. But, at $13 a share, GSK's bid was deemed "inadequate" by the HGS board. Recent history in the biotech sector shows how high the stakes are in such negotiations. Since last November, six biopharma buyouts have exceeded $1 billion each, with Gilead Sciences' purchase last year of the hepatitis C specialist Pharmasset topping the charts at a whopping $11.2 billion, the highest ever paid for a clinical-stage biotech and an 89% premium to its share price at the time. More recently, in April AstraZeneca paid $1.3 billion for Ardea Biosciences, a company with cancer and gout drugs in the pipeline but nothing on the market.One person watching the upward clime of such deals is biopharma analyst Joseph Schwartz, a managing director at Leerink Swann in Boston. Mark Ratner sought out Schwartz, who was named the top stock picker for pharmaceuticals in the last year's FT/StarMine Analyst Awards, for his views on what's behind the recent buyout spending. PMID:22673987

  11. Assessing the impacts of the first year of rotavirus vaccination in the United Kingdom.

    PubMed

    Marlow, Robin; Muir, Peter; Vipond, Barry; Lyttle, Mark; Trotter, Caroline; Finn, Adam

    2015-12-01

    The United Kingdom (UK) added rotavirus (RV) vaccine (Rotarix GlaxoSmithKline) to the national vaccine schedule in July 2013. During the 2012-2014 rotavirus seasons, children presenting to the Bristol Royal Hospital for Children Emergency Department with gastroenteritis symptoms had stool virology analysis (real-time PCR) and clinical outcome recorded. Nosocomial cases were identified as patients with non-gastroenteritis diagnosis testing positive for rotavirus > 48h after admission. In comparison to average pre-vaccine seasons, in the first year after vaccine introduction there were 48% fewer attendances diagnosed with gastroenteritis, 53% reduction in gastroenteritis admissions and a total saving of 330 bed-days occupancy. There was an overall reduction in number of rotavirus-positive stool samples with 94% reduction in children aged under one year and a 65% reduction in those too old to have been vaccinated. In the first year after the introduction of universal vaccination against rotavirus we observed a profound reduction in gastroenteritis presentations and admissions with a substantial possible herd effect seen in older children. Extrapolating these findings to the UK population we estimate secondary healthcare savings in the first year of ca £7.5 (€10.5) million. Ongoing surveillance will be required to determine the long-term impact of the RV immunisation programme. PMID:26675375

  12. New Compound Sets Identified from High Throughput Phenotypic Screening Against Three Kinetoplastid Parasites: An Open Resource

    PubMed Central

    Peña, Imanol; Pilar Manzano, M.; Cantizani, Juan; Kessler, Albane; Alonso-Padilla, Julio; Bardera, Ana I.; Alvarez, Emilio; Colmenarejo, Gonzalo; Cotillo, Ignacio; Roquero, Irene; de Dios-Anton, Francisco; Barroso, Vanessa; Rodriguez, Ana; Gray, David W.; Navarro, Miguel; Kumar, Vinod; Sherstnev, Alexander; Drewry, David H.; Brown, James R.; Fiandor, Jose M.; Julio Martin, J.

    2015-01-01

    Using whole-cell phenotypic assays, the GlaxoSmithKline high-throughput screening (HTS) diversity set of 1.8 million compounds was screened against the three kinetoplastids most relevant to human disease, i.e. Leishmania donovani, Trypanosoma cruzi and Trypanosoma brucei. Secondary confirmatory and orthogonal intracellular anti-parasiticidal assays were conducted, and the potential for non-specific cytotoxicity determined. Hit compounds were chemically clustered and triaged for desirable physicochemical properties. The hypothetical biological target space covered by these diversity sets was investigated through bioinformatics methodologies. Consequently, three anti-kinetoplastid chemical boxes of ~200 compounds each were assembled. Functional analyses of these compounds suggest a wide array of potential modes of action against kinetoplastid kinases, proteases and cytochromes as well as potential host–pathogen targets. This is the first published parallel high throughput screening of a pharma compound collection against kinetoplastids. The compound sets are provided as an open resource for future lead discovery programs, and to address important research questions. PMID:25740547

  13. [Narcolepsy with cataplexy: an autoimmune disease?].

    PubMed

    Jacob, Louis; Dauvilliers, Yves

    2014-12-01

    Narcolepsy type 1 (also named narcolepsy-cataplexy or hypocretin deficiency syndrome) is a rare sleep disorder characterized by excessive daytime sleepiness and cataplexy, plus frequently hypnagogic hallucinations, sleep paralysis and nocturnal sleep disturbances. Narcolepsy type 1 is an immune system-associated disease linked with the destruction of 70.000-90.000 hypocretin neurons notably involved in wakefulness. Among narcoleptic patients, 98% are positive for HLA-DQB1*06:02, a HLA class II allele, against 20-25% in general population. Individuals carrying HLA-DQB1*06:02 have an extraordinary risk to develop narcolepsy (odd ratio: 251). Other genes involved in CD4+ T cells and immune system activation as T-cell receptor ? are also associated with narcolepsy. The development of the disease is linked with environmental factors such as influenza and streptococcal infections. Narcolepsy type 1 incidence also increased in Europe following the use of Pandemrix, a 2009 H1N1 AS03-adjuvanted vaccine manufactured by GlaxoSmithKline. Interestingly, such increase was not observed with Arepanrix, another vaccine developed by GSK very similar to Pandemrix. PMID:25537044

  14. Searching for Dark Matter Annihilation in the Smith High-Velocity Cloud

    NASA Technical Reports Server (NTRS)

    Drlica-Wagner, Alex; Gomez-Vargas, German A.; Hewitt, John W.; Linden, Tim; Tibaldo, Luigi

    2014-01-01

    Recent observations suggest that some high-velocity clouds may be confined by massive dark matter halos. In particular, the proximity and proposed dark matter content of the Smith Cloud make it a tempting target for the indirect detection of dark matter annihilation. We argue that the Smith Cloud may be a better target than some Milky Way dwarf spheroidal satellite galaxies and use gamma-ray observations from the Fermi Large Area Telescope to search for a dark matter annihilation signal. No significant gamma-ray excess is found coincident with the Smith Cloud, and we set strong limits on the dark matter annihilation cross section assuming a spatially extended dark matter profile consistent with dynamical modeling of the Smith Cloud. Notably, these limits exclude the canonical thermal relic cross section (approximately 3 x 10 (sup -26) cubic centimeters per second) for dark matter masses less than or approximately 30 gigaelectronvolts annihilating via the B/B- bar oscillation or tau/antitau channels for certain assumptions of the dark matter density profile; however, uncertainties in the dark matter content of the Smith Cloud may significantly weaken these constraints.

  15. Searching for dark matter annihilation in the Smith high-velocity cloud

    SciTech Connect

    Drlica-Wagner, Alex; Gómez-Vargas, Germán A.; Hewitt, John W.; Linden, Tim; Tibaldo, Luigi

    2014-07-20

    Recent observations suggest that some high-velocity clouds may be confined by massive dark matter halos. In particular, the proximity and proposed dark matter content of the Smith Cloud make it a tempting target for the indirect detection of dark matter annihilation. We argue that the Smith Cloud may be a better target than some Milky Way dwarf spheroidal satellite galaxies and use ?-ray observations from the Fermi Large Area Telescope to search for a dark matter annihilation signal. No significant ?-ray excess is found coincident with the Smith Cloud, and we set strong limits on the dark matter annihilation cross section assuming a spatially extended dark matter profile consistent with dynamical modeling of the Smith Cloud. Notably, these limits exclude the canonical thermal relic cross section (? 3 × 10{sup –26} cm{sup 3} s{sup –1}) for dark matter masses ? 30 GeV annihilating via the b b-bar or ?{sup +}?{sup –} channels for certain assumptions of the dark matter density profile; however, uncertainties in the dark matter content of the Smith Cloud may significantly weaken these constraints.

  16. Functional Analysis of the Mouse Scn8a Sodium Channel Marianne R. Smith,1 Raymond D. Smith,1 Nicholas W. Plummer,2 Miriam H. Meisler,2 and Alan L. Goldin1

    E-print Network

    Goldin, Alan L.

    Functional Analysis of the Mouse Scn8a Sodium Channel Marianne R. Smith,1 Raymond D. Smith,1Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109-0618 The mouse Scn8a sodiumDNA clone encoding the mouse Scn8a sodium channel and expressed it in Xenopus oocytes

  17. AMERICAN JOURNAL OF SCIENCE KLINE GEOLOGY LABORATORY

    E-print Network

    Royer, Dana

    a distinct atmospheric O2 peak during the late Paleozoic (>30%) followed by low values near the Triassic-Jurassic), resolution of an atmospheric O2 spike during the Carboniferous and Permian that is coincident with a period

  18. K-Lines: A Theory of Memory

    E-print Network

    Minsky, Marvin

    1979-06-01

    Most theories of memory suggest that when we learn or memorize something, some "representation" of that something is constructed, stored and later retrieved. This raises questions like: How is information represented? ...

  19. Improving the Mapping of Smith-Waterman Sequence Database Searches onto CUDA-Enabled GPUs

    PubMed Central

    Huang, Liang-Tsung; Wu, Chao-Chin; Lai, Lien-Fu; Li, Yun-Ju

    2015-01-01

    Sequence alignment lies at heart of the bioinformatics. The Smith-Waterman algorithm is one of the key sequence search algorithms and has gained popularity due to improved implementations and rapidly increasing compute power. Recently, the Smith-Waterman algorithm has been successfully mapped onto the emerging general-purpose graphics processing units (GPUs). In this paper, we focused on how to improve the mapping, especially for short query sequences, by better usage of shared memory. We performed and evaluated the proposed method on two different platforms (Tesla C1060 and Tesla K20) and compared it with two classic methods in CUDASW++. Further, the performance on different numbers of threads and blocks has been analyzed. The results showed that the proposed method significantly improves Smith-Waterman algorithm on CUDA-enabled GPUs in proper allocation of block and thread numbers. PMID:26339591

  20. Geology, paleoclimatology and the evolution of the kidney: some explorations into the legacy of Homer Smith.

    PubMed

    Kooman, Jeroen P

    2012-01-01

    The aim of this review is to perform an overview of the relation between kidney development in different species and new developments in plate tectonics and paleoclimatology, which likely had a remarkable effect on evolution. The review follows the ideas of Homer Smith, but adds new data on the subjects which were unknown in Homer Smith's time. The structure and function of the kidney are a result of hundreds of millions of years of evolution, in which adaptations had to be made in response to environmental demands while maintaining the kidney's integrated function. The ideas of Homer Smith have greatly contributed to our understanding of this process, and continue to be of relevance both for researchers as well as physicians working in the field of kidney disease. PMID:22572704

  1. Groundwater and surface-water interaction within the upper Smith River Watershed, Montana 2006-2010

    USGS Publications Warehouse

    Caldwell, Rodney R.; Eddy-Miller, Cheryl A.

    2013-01-01

    The 125-mile long Smith River, a tributary of the Missouri River, is highly valued as an agricultural resource and for its many recreational uses. During a drought starting in about 1999, streamflow was insufficient to meet all of the irrigation demands, much less maintain streamflow needed for boating and viable fish habitat. In 2006, the U.S. Geological Survey, in cooperation with the Meagher County Conservation District, initiated a multi-year hydrologic investigation of the Smith River watershed. This investigation was designed to increase understanding of the water resources of the upper Smith River watershed and develop a detailed description of groundwater and surface-water interactions. A combination of methods, including miscellaneous and continuous groundwater-level, stream-stage, water-temperature, and streamflow monitoring was used to assess the hydrologic system and the spatial and temporal variability of groundwater and surface-water interactions. Collectively, data are in agreement and show: (1) the hydraulic connectedness of groundwater and surface water, (2) the presence of both losing and gaining stream reaches, (3) dynamic changes in direction and magnitude of water flow between the stream and groundwater with time, (4) the effects of local flood irrigation on groundwater levels and gradients in the watershed, and (5) evidence and timing of irrigation return flows to area streams. Groundwater flow within the alluvium and older (Tertiary) basin-fill sediments generally followed land-surface topography from the uplands to the axis of alluvial valleys of the Smith River and its tributaries. Groundwater levels were typically highest in the monitoring wells located within and adjacent to streams in late spring or early summer, likely affected by recharge from snowmelt and local precipitation, leakage from losing streams and canals, and recharge from local flood irrigation. The effects of flood irrigation resulted in increased hydraulic gradients (increased groundwater levels relative to stream stage) or even reversed gradient direction at several monitoring sites coincident with the onset of nearby flood irrigation. Groundwater-level declines in mid-summer were due to groundwater withdrawals and reduced recharge from decreased precipitation, increased evapotranspiration, and reduced leakage in some area streams during periods of low flow. Groundwater levels typically rebounded in late summer, a result of decreased evapotranspiration, decreased groundwater use for irrigation, increased flow in losing streams, and the onset of late-season flood irrigation at some sites. The effect of groundwater and surface-water interactions is most apparent along the North and South Forks of the Smith River where the magnitude of streamflow losses and gains can be greater than the magnitude of flow within the stream. Net gains consistently occurred over the lower 15 miles of the South Fork Smith River. A monitoring site near the mouth of the South Fork Smith River gained (flow from the groundwater to the stream) during all seasons, with head gradients towards the stream. Two upstream sites on the South Fork Smith River exhibited variable conditions that ranged from gaining during the spring, losing (flowing from the stream to the groundwater) during most of the summer as groundwater levels declined, and then approached or returned to gaining conditions in late summer. Parts of the South Fork Smith River became dry during periods of losing conditions, thus classifying this tributary as intermittent. The North Fork Smith River is highly managed at times through reservoir releases. The North Fork Smith River was perennial throughout the study period although irrigation diversions removed a large percentage of streamflow at times and losing conditions persisted along a lower reach. The lowermost reach of the North Fork Smith River near its mouth transitioned from a losing reach to a gaining reach throughout the study period. Groundwater and surface-water interactions occur downstream from the confluence of the North and South F

  2. Revisiting "No Easy Answers": Application of Sally Smith's Methods in the Lab School of Washington High School Program

    ERIC Educational Resources Information Center

    Reynolds, Meredith

    2010-01-01

    The first edition of "No Easy Answers" (Smith, 1995) was published in 1979, thirty years ago. That seminal work is as relevant today as it was when the book first appeared. This article provides a description of how Sally Smith's Academic Club Method is implemented in the High School program of The Lab School of Washington.

  3. 77 FR 48775 - Changes To Implement the Inventor's Oath or Declaration Provisions of the Leahy-Smith America...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-14

    ... Implement the Inventor's Oath or Declaration Provisions of the Leahy-Smith America Invents Act, 77 FR 982... Inventor's Oath or Declaration Provisions of the Leahy-Smith America Invents Act, 77 FR at 983. The public... FR at 1000. The public submitted a number of comments suggesting that the Office should not...

  4. 78 FR 16182 - Changes To Implement the First Inventor To File Provisions of the Leahy-Smith America Invents Act...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-14

    ...Changes To Implement the First Inventor To File Provisions of the Leahy-Smith America...the changes in the first inventor to file provisions of the Leahy-Smith America Invents Act (AIA) (First Inventor to File Final Rule). Due to a technical...

  5. 78 FR 11023 - Changes To Implement the First Inventor To File Provisions of the Leahy-Smith America Invents Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-14

    ...Examination Guidelines for Implementing the First Inventor To File Provisions of the Leahy-Smith...RIN 0651-AC77 Changes To Implement the First Inventor To File Provisions of the Leahy-Smith...convert the U.S. patent system from a ``first to invent'' system to a ``first...

  6. 78 FR 11059 - Examination Guidelines for Implementing the First Inventor To File Provisions of the Leahy-Smith...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-14

    ...Examination Guidelines for Implementing the First Inventor To File Provisions of the Leahy-Smith...publishing examination guidelines concerning the first inventor to file provisions of the Leahy-Smith...convert the U.S. patent system from a ``first to invent'' system to a ``first...

  7. 37 CFR 1.109 - Effective filing date of a claimed invention under the Leahy-Smith America Invents Act.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... claimed invention under the Leahy-Smith America Invents Act. 1.109 Section 1.109 Patents, Trademarks, and... a claimed invention under the Leahy-Smith America Invents Act. (a) The effective filing date for a claimed invention in a patent or application for patent, other than in a reissue application or...

  8. 37 CFR 1.109 - Effective filing date of a claimed invention under the Leahy-Smith America Invents Act.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... claimed invention under the Leahy-Smith America Invents Act. 1.109 Section 1.109 Patents, Trademarks, and... a claimed invention under the Leahy-Smith America Invents Act. (a) The effective filing date for a claimed invention in a patent or application for patent, other than in a reissue application or...

  9. 78 FR 11023 - Changes To Implement the First Inventor To File Provisions of the Leahy-Smith America Invents Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-14

    ... AIA in a separate rulemaking. See Changes To Implement Derivation Proceedings, 77 FR 56068 (Sept. 11... Changes To Implement the First Inventor To File Provisions of the Leahy-Smith America Invents Act, 77 FR... First Inventor To File Provisions of the Leahy-Smith America Invents Act, 77 FR 43759 (July 26,...

  10. 78 FR 11059 - Examination Guidelines for Implementing the First Inventor To File Provisions of the Leahy-Smith...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-14

    ... of the Leahy-Smith America Invents Act, 77 FR 43742 (July 26, 2012) (notice of proposed rulemaking... America Invents Act, 77 FR 43759 (July 26, 2012) (notice of proposed examination guidelines). The Office... First Inventor To File Provisions of the Leahy-Smith America Invents Act, 77 FR 49427 (Aug. 16,...

  11. Sir James Edward Smith (1759-1828) MD FRS, botanist, co-founder of the Linnean Society of London.

    PubMed

    Hawgood, Barbara J

    2009-05-01

    James Edward Smith's interest in botany led him to enter medicine at Edinburgh in 1781. Smith was continuing his medical studies in London when Sir Joseph Banks (1743-1820) suggested to him that he should purchase the collection of the famous Swedish naturalist Carl Linnaeus that had just been offered to Banks. Smith bought the Linnean Collection and Library in 1784. In 1786 he was awarded the degree of Doctor of Medicine from Leiden. In 1788 Smith, with two associates, founded the Linnean Society of London and became President for life. Smith turned from medicine to natural history as a lecturer and writer. During his lifetime he produced numerous botanical works of high value, including The English Flora (1824-28), and he did much to popularize botany. PMID:19401517

  12. William Smith's Biblical Notebook (1729): A Manuscript Recovered Among New College's early printed books there is a curious double volume, undistinguished in

    E-print Network

    Flynn, E. Victor

    1729-01-01

    William Smith's Biblical Notebook (1729): A Manuscript Recovered Among New College's early printed. It is a student notebook, signed by one William Smith and dated by him to 1729. A later owner has found a portrait of this Smith and pasted it into the front of the notebook.2 Assuming the portrait is correctly matched

  13. The strategy concept and John Maynard Smith's influence on theoretical biology

    E-print Network

    The strategy concept and John Maynard Smith's influence on theoretical biology MANFRED D Complexity and Dynamics, Center for Biology and Society, Arizona State University, Tempe, AZ, 85287-4501, USA; 2 Institute for Theoretical Biology, Humboldt Universita¨t zu Berlin, Invalidenstraße 43, 10115

  14. Discovery and antitumor activities of constituents from Cyrtomium fortumei (J.) Smith rhizomes

    PubMed Central

    2013-01-01

    Background Cyrtomium fortumei (J.) Smith is an important Chinese herbal medicine because of its biological functions. However, systematic and comprehensive studies on the phytochemicals from Cyrtomium fortumei (J.) Smith and their bioactivity are limited. Results Using the bioassay-guided technique, the ethyl acetate and n-BuOH extracts of the rhizomes of Cyrtomium fortumei (J.) Smith were shown to exhibit good antitumor activities, consequently leading to the isolation of 23 compounds. All compounds were isolated from the plant for the first time. The inhibitory activities of these compounds were investigated on tumor cells MGC-803, PC3, and A375 in vitro by MTT (thiazolyl blue tetrazolium bromide) assay, and the results showed that pimpinellin (3) had potent cytotoxic activities against the three cell lines, with the IC50 values of 14.4?±?0.3??M, 20.4?±?0.5??M, and 29.2?±?0.6??M, respectively. The mechanism of the antitumor action indicated that pimpinellin inhibited the growth of MGC-803 cells via the induction of tumor cell apoptosis, with apoptosis ratio of 27.44% after 72?h of treatment at 20??M. Conclusions This study suggests that most of the compounds from the roots of Cyrtomium fortumei (J.) Smith could inhibit the growth of human carcinoma cells. Moreover, pimpinellin inhibited the growth of tumor cells via the induction of tumor cell apoptosis. PMID:23379693

  15. Smith (1972) first reported Epinephe-lus striatus (Nassau grouper) spawn-

    E-print Network

    1972-01-01

    642 Smith (1972) first reported Epinephe- lus striatus (Nassau grouper) spawn- ing aggregations Stocking Island (approximately 120 km NW of Long-distance movement of a Nassau grouper (Epinephelus by their external tags. Results The recaptured Nassau grouper was tracked by ultrasound at its presumed "home reef

  16. Back to the Future on Gender and Anti-School Boys: A Response to Jeffrey Smith

    ERIC Educational Resources Information Center

    Abraham, John

    2008-01-01

    This article examines recent claims by Jeffrey Smith that: (1) "hegemonic masculinity" is an expression of working class counter-school culture; (2) some teachers are "cultural accomplices" in constructing "hegemonic masculinities" of anti-school working class boys, thereby contributing to their underachievement; and (3) these "cultural…

  17. The Great Albatross Philippine Expedition and Its Fishes DAVID G. SMITH and JEFFREY T. WILLIAMS

    E-print Network

    The Great Albatross Philippine Expedition and Its Fishes DAVID G. SMITH and JEFFREY T. WILLIAMS assignment of the Albatross's 39-year The expedition returned great quantities of career. It came about by the Depression. The and Roy Chapman Andrews. The expedi- material from the Philippine Expedition tion consisted

  18. The Bark Bilinear Transform Julius O. Smith, III Jonathan S. Abel

    E-print Network

    Smith III, Julius Orion

    The Bark Bilinear Transform Julius O. Smith, III Jonathan S. Abel CCRMA Abel Innovations Stanford@ccrma.stanford.edu Abstract Use of a bilinear conformal map to achieve a frequency warping nearly identical to the Bark scale of the im­ portant spectral transformations for audio is warping to the Bark frequency scale. Based

  19. Scott Hitchner and Jesse Smith, RAREC farm staff, carry cabbage from the field

    E-print Network

    Vetriani, Costantino

    Scott Hitchner and Jesse Smith, RAREC farm staff, carry cabbage from the field June Sudal, RAREC farm staff, harvests cabbage Michelle Casella with harvested cabbage Report to the New Jersey State Board of Agriculture December 2009 Spotlight on Cabbage Gleaning at RAREC On November 17, Farmers

  20. Using Interaction to Compute Better Probability Estimates in Plan Graphs Daniel Bryce David E. Smith

    E-print Network

    Kambhampati, Subbarao

    Research Center Tempe Arizona 85287­5406 Moffet Field, CA 94035­1000 dan.bryce@asu.edu de2smith to compute estimates of the probability that propositions can be achieved and actions can be performed through each possible action to the action effects, and hence to the propositions at the next layer

  1. A Musical Instrument Based on a Bioacoustic Model of a Cicada Tamara Smyth, Julius O. Smith

    E-print Network

    Smyth, Tamara

    A Musical Instrument Based on a Bioacoustic Model of a Cicada Tamara Smyth, Julius O. Smith Center an acoustic musical instrument? By creating a physical model of the cicada's sound mech­ anism on other such bioacoustic models. 2 The Sound Mechanism of the Cicada The cicada produces it

  2. A Musical Instrument Based on a Bioacoustic Model of a Cicada Tamara Smyth, Julius O. Smith

    E-print Network

    Smyth, Tamara

    A Musical Instrument Based on a Bioacoustic Model of a Cicada Tamara Smyth, Julius O. Smith Center an acoustic musical instrument? By creating a physical model of the cicada's sound mech- anism on other such bioacoustic models. 2 The Sound Mechanism of the Cicada The cicada produces it

  3. SAM: A Flexible and Secure Auction Architecture Using Trusted Hardware Adrian Perrig y Sean Smith z

    E-print Network

    Perrig, Adrian

    , such as bids, bidding strategies --- and possibly fraud patterns and investigation data. #15; Auctions involveSAM: A Flexible and Secure Auction Architecture Using Trusted Hardware Adrian Perrig y Sean Smith z security concerns. In particular, most auction systems force buyers and sellers to trust the auctioneer

  4. Ideology and Reform in Teacher Education in England: Some Reflections on Cochran-Smith and Fries.

    ERIC Educational Resources Information Center

    Furlong, John

    2002-01-01

    Presents an international perspective on Cochran-Smith and Fries' recent analysis of the ways that two competing ideologies (deregulation and professionalization) are being employed in the United States to support teacher education reform, noting important differences between the United States and England in how these ideologies have been advanced…

  5. Sally L. Smith: A Genius at Seeing the Potential in People

    ERIC Educational Resources Information Center

    Edgerton, Mary Allen

    2010-01-01

    What this author admired most about Sally Smith was the fact that she was a visionary about people and what they could accomplish. She saw more potential in a person--young or old--than anybody or even they themselves, frankly, had ever even considered possible. She was a genius at seeing the potential in people, expecting them to find it in…

  6. Adam Smith and the Educative Critique: A Response to My Commentators

    ERIC Educational Resources Information Center

    Weinstein, Jack Russell

    2015-01-01

    This paper is both a response to the four reviewers in a special symposium on my book Adam Smith's Pluralism and a substantive discussion of philosophy of education. In it, I introduce what I call "the educative critique," a mode of analysis similar to Marxist, feminist, or postcolonial critiques, but focusing on the educative role of a…

  7. Another Look at the Glass and Smith Study on Class Size

    ERIC Educational Resources Information Center

    Phelps, James L.

    2011-01-01

    One of the most influential studies affecting educational policy is Glass and Smith's 1978 study, "Meta-Analysis of Research on the Relationship of Class-Size and Achievement." Since its publication, educational policymakers have referenced it frequently as the justification for reducing class size. While teachers and the public had long believed…

  8. Celebrating the Past, Ensuring the Future--A Profile of President Glenn Smith

    ERIC Educational Resources Information Center

    Blumenthal, Anita

    2013-01-01

    "I had no idea how to convince someone to hire me," recalls APPA President, Glen Smith. His first interview was with Bryn Mawr College, a small, prestigious private college with Quaker roots, located 12 miles west of Philadelphia. That was in 1997, after 24 years in the Naval Civil Engineer Corps, and he still remembers a certain…

  9. 78 FR 59368 - Notice of Joint Meeting for Captain John Smith Chesapeake National Historic Trail Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-26

    ... Advisory Council and Star-Spangled Banner National Historic Trail Advisory Council AGENCY: National Park... John Smith Chesapeake National Historic Trail and the Star-Spangled Banner National Historic Trail will.... The Star-Spangled Banner National Historic Trail consists of ``water and overland routes...

  10. What’s in a Surname? Physique, Aptitude, and Sports Type Comparisons between Tailors and Smiths

    PubMed Central

    Voracek, Martin; Rieder, Stephan; Stieger, Stefan; Swami, Viren

    2015-01-01

    Combined heredity of surnames and physique, coupled with past marriage patterns and trade-specific physical aptitude and selection factors, may have led to differential assortment of bodily characteristics among present-day men with specific trade-reflecting surnames (Tailor vs. Smith). Two studies reported here were partially consistent with this genetic-social hypothesis, first proposed by Bäumler (1980). Study 1 (N = 224) indicated significantly higher self-rated physical aptitude for prototypically strength-related activities (professions, sports, hobbies) in a random sample of Smiths. The counterpart effect (higher aptitude for dexterity-related activities among Tailors) was directionally correct, but not significant, and Tailor-Smith differences in basic physique variables were nil. Study 2 examined two large total-population-of-interest datasets (Austria/Germany combined, and UK: N = 7001 and 20532) of men’s national high-score lists for track-and-field events requiring different physiques. In both datasets, proportions of Smiths significantly increased from light-stature over medium-stature to heavy-stature sports categories. The predicted counterpart effect (decreasing prevalences of Tailors along these categories) was not supported. Related prior findings, the viability of possible alternative interpretations of the evidence (differential positive selection for trades and occupations, differential endogamy and assortative mating patterns, implicit egotism effects), and directions for further inquiry are discussed in conclusion. PMID:26161803

  11. THE SCALING OF FLUVIAL LANDSCAPES Bjrn Birnir # Terence R. Smith + \\Lambda George E. Merchant +

    E-print Network

    California at Santa Barbara, University of

    THE SCALING OF FLUVIAL LANDSCAPES Björn Birnir # Terence R. Smith + \\Lambda George E. Merchant at Santa Barbara, California 93106, USA ABSTRACT The analysis of a family of physically­based landscape of river basins. The par­ tial differential equation determine the scaling invariances of the landscape

  12. Dr. Dan Smith, PhD Geography Department, University of Victoria

    E-print Network

    Smith, Dan

    is eroding at this location, an estimation of a rate of erosion and the potential implications of the bank, debris obstructions and possibly by poor rip-rap construction. Only a rough rate of erosion couldDr. Dan Smith, PhD Geography Department, University of Victoria RIVER BANK EROSION, BEAVER RIVER

  13. A Case Study of Early Development in Smith-Magenis Syndrome

    ERIC Educational Resources Information Center

    Fidler, Deborah J.; Philofsky, Amy D.; Hepburn, Susan L.

    2006-01-01

    The aim of this article is to provide an in-depth description of early development in a young child with Smith-Magenis syndrome (SMS). SMS is a multisystem, neurodevelopmental genetic disorder associated with mental retardation that predisposes individuals to a distinct pattern of maladaptive behaviors and other neuropsychological impairments.…

  14. Stress in Families of Young Children with Down Syndrome, Williams Syndrome, and Smith-Magenis Syndrome.

    ERIC Educational Resources Information Center

    Fidler, Deborah J.; Hodapp, Robert M.; Dykens, Elizabeth M.

    2000-01-01

    Compared stress levels in families of children with Down syndrome (DS), Williams syndrome (WS), or Smith-Magenis syndrome (SMS). Found that DS families experienced less Pessimism than others and less Parent and Family Problems than SMS families. Strongest predictors of Parent and Family Problems were maladaptive behavior in SMS, younger age in DS,…

  15. AUGMENTING COMPUTER MUSIC WITH JUST-IN-TIME COMPILATION Wesley Smith, Graham Wakefield

    E-print Network

    California at Santa Barbara, University of

    AUGMENTING COMPUTER MUSIC WITH JUST-IN-TIME COMPILATION Wesley Smith, Graham Wakefield University the potential of just-in-time compilation for computer music software to evade compromises of flexibil- ity) compilation to relax tensions of run-time flexibility and effi- ciency. JIT compilation allows the compilation

  16. Cryptographic Support in a Gigabit Network Jonathan M. Smith (jms@aurora.cis.upenn.edu)

    E-print Network

    Smith, Jonathan M.

    Cryptographic Support in a Gigabit Network Jonathan M. Smith (jms@aurora.cis.upenn.edu) C. Brendan S. Traw (traw@aurora.cis.upenn.edu) David J. Farber (farber@cis.upenn.edu) Distributed Systems boards were built to understand architectural issues in providing crypto- graphic support for the AURORA

  17. Building social jus.ce through library and informa.on science Lauren Smith

    E-print Network

    Strathclyde, University of

    issues of social jus.ce. Findings: Current systems of management and policy for building social jus.ce through representa.ve democra.c systems. In order to effecBuilding social jus.ce through library and informa.on science Lauren Smith lauren

  18. Smart Cards in Hostile Environments Howard Gobioff Sean Smith J. D. Tygar

    E-print Network

    Tygar, Doug

    Smart Cards in Hostile Environments Howard Gobioff Sean Smith J. D. Tygar September 14, 1995 CMU hears the claim that smart cards are the solution to a number of security problems, including those arising in point-of-sale systems. This paper argues that many proposed smart card systems still lack

  19. Smart Cards in Hostile Environments Howard Gobio Sean Smith J. D. Tygar Bennet Yee

    E-print Network

    Tygar, Doug

    Smart Cards in Hostile Environments Howard Gobio Sean Smith J. D. Tygar Bennet Yee Carnegie Mellon@cs.ucsd.edu Abstract One often hears the claim that smart cards are the solution to a number of security problems necessary for the secure smart card point-of-sale transactions. Many proposed systems failto provide

  20. Smart Cards in Hostile Environments Howard Gobioff Sean Smith J. D. Tygar Bennet Yee

    E-print Network

    Yee, Bennet

    Smart Cards in Hostile Environments Howard Gobioff Sean Smith J. D. Tygar Bennet Yee Carnegie@cs.ucsd.edu Abstract One often hears the claim that smart cards are the solution to a number of security problems necessary for the secure smart card point­of­sale transactions. Many proposed systems fail to provide

  1. UWAgents: A Mobile Agent System Optimized for Grid Computing Munehiro Fukuda Duncan Smith

    E-print Network

    Fukuda, Munehiro

    from the following advan- tages of mobile agents: their navigational autonomy as- sists the search to their user applica- tions [11]. The latter implements job scheduling as a form of agent negotiation [2UWAgents: A Mobile Agent System Optimized for Grid Computing Munehiro Fukuda Duncan Smith Computing

  2. Rotating modulation collimator imagers D.M. Smith a,*, G.J. Hurford b

    E-print Network

    California at Berkeley, University of

    Rotating modulation collimator imagers D.M. Smith a,*, G.J. Hurford b , S.E. Boggs c a Department, USA Abstract Rotating modulation collimators (RMCs) are one member of a family of techniques for X and instrumentation 1. Introduction Rotating modulation collimators have been used for many years for X-ray imaging

  3. LIFE HISTORY MONITORING OF SALMONIDS IN THE WEST FORK SMITH RIVER, UMPQUA BASIN, OREGON

    EPA Science Inventory

    As a life-cycle monitoring basin for the Oregon Salmon Plan, the Oregon Department of Fish and Wildlife has estimated adult returns, distribution and smolt outmigration of coho, chinook and winter steelhead in the West Fork Smith River since 1998. In 2001/2002, the Environmenta...

  4. 2. Photocopied October 1976, from b.f smithIllistrations of the Croton ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Photocopied October 1976, from b.f smithIllistrations of the Croton Aqueduct, New York, Wiley and Putnam, 1843. TITLE PAGE. SHOWS N.Y.C. FOUNTAIN MADE POSSIBLE BY THE AQUEDUCT. - Old Croton Aqueduct, New York, New York County, NY

  5. Linda B. Smith Department of Psychological and Brain Sciences & The Program in Cognitive Science

    E-print Network

    Indiana University

    of Experimental Child Psychologv. 20, 352-362. #12;Jusczyk, P., Rosner, B., Cutting, J., Foard, C., & Smith, L for Research In Child Development, Ethics Committee, 1997-1999 National Institutes of Health, Study Section: Learning. Memory and Cognition, 1981-84 Child Development. 1984-1995, 1997-2000 Contemporary Psychology

  6. A Dialog Control Algorithm and Its Performance Ronnie W. Smith \\Lambda

    E-print Network

    Smith, Ronnie W.

    contains a model of the device to be repaired, debugging and repair proce­ dures, voice recognitionA Dialog Control Algorithm and Its Performance Ronnie W. Smith \\Lambda Dept. of Computer Science, NC 27706 awb@cs.duke.edu Abstract A pragmatic architecture for voice dialog ma­ chines aimed

  7. Diversity and biogeography of testate amoebae Humphrey Graham Smith Anatoly Bobrov Enrique Lara

    E-print Network

    Diversity and biogeography of testate amoebae Humphrey Graham Smith Æ Anatoly Bobrov Æ Enrique Lara Abstract Testate amoebae are amoeboid protists inhabiting a test (shell). They occur globally in soils Fossil testates Á Testate amoebae Published in Biodiversity and Conservation 17, issue 2, 329-343, 2008

  8. Travel Time Models MacGregor Smith & Cruz State Dependent Travel Time Models, Properties,

    E-print Network

    Cruz, Frederico

    Travel Time Models MacGregor Smith & Cruz State Dependent Travel Time Models, Properties, & Kerner networks is an accurate estimate of travel time on arterial links, highway, and freeways way to esti- mate travel times for this complex task. Realistically, however, travel time is a random

  9. Sally Smith's Arts-Based and Integrated Curricular Approach to Educating Students with Learning Disabilities

    ERIC Educational Resources Information Center

    Durham, Jennifer

    2010-01-01

    Founded in 1967, The Lab School of Washington (LSW) has been educating students with learning disabilities using an arts-based curriculum for over 50 years. Sally Smith originally started the school out of frustration with the inability of traditional educational environments to reach her intelligent, but learning disabled, young son and others…

  10. Discovery of nitrogen in Saturn's inner magnetosphere H. T. Smith,1

    E-print Network

    Johnson, Robert E.

    Discovery of nitrogen in Saturn's inner magnetosphere H. T. Smith,1 M. Shappirio,2 E. C. Sittler,2 detected N+ in Saturn's magnetosphere in the range L $ 3.5 to $9.5 Saturn Radii (Rs) using data collected by the Cassini Plasma Spectrometer during Saturn Orbit Insertion and the following orbit (Rev A). The presence

  11. "Comments on Coulter and Smith": Relational Ontological Commitments in Narrative Research

    ERIC Educational Resources Information Center

    Clandinin, D. Jean; Murphy, M. Shaun

    2009-01-01

    In this comment article on Coulter and Smith (2009), the authors raise concerns that focusing exclusively on issues of representation may lead readers to misunderstandings about narrative research. The authors argue that narrative ways of thinking about the phenomena under study are interwoven with narrative research methodologies. Drawing on…

  12. The Compositional Evolution of the Murid Genome Nick G.C. Smith,1

    E-print Network

    Eyre-Walker, Adam

    The Compositional Evolution of the Murid Genome Nick G.C. Smith,1 Adam Eyre-Walker2 1 Department, Sweden 2 Centre for the Study of Evolution & School of Biological Sciences, University of Sussex, Sussex variation in isochore base composition than do most other mammals, a difference which has been referred

  13. Sound Signal Statistics Leslie S Smith, Department of Computing Science and Maths, University of Stirling,

    E-print Network

    Smith, Leslie S.

    Sound Signal Statistics Leslie S Smith, Department of Computing Science and Maths, University of Stirling, Stirling, Scotland. lss@cs.stir.ac.uk Introduction: How might one analyse sound? Follow is auditory processing like it is? ·Because of sound statistics, ecological requirements, what is biologically

  14. Supporting Information McConnell Smith et al. 10.1073/pnas.0810588106

    E-print Network

    Monnat, Ray

    M and a temperature optimum of 35 °C. The Y2 construct was identified in an in vivo screen for enzyme variantsSupporting Information McConnell Smith et al. 10.1073/pnas.0810588106 Fig. S1. Variant enzyme substitutions (see arrows above) increase DNA binding affinity and improve catalytic activity at physiological

  15. Tissue-specific regulatory elements in mammalian Andrew D Smith1,3

    E-print Network

    Smith, Andrew D.

    REPORT Tissue-specific regulatory elements in mammalian promoters Andrew D Smith1,3 , Pavel Sumazin@cshl.edu Received 14.6.06; accepted 10.11.06 Transcription factor-binding sites and the cis-regulatory modules-specific motifs and modules, and cis-regulatory elements. Predicted regulatory interactions are supported

  16. 77 FR 58181 - Power Resources, Inc., Smith Ranch Highland Uranium Project; License Renewal Request, Opportunity...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-19

    ... NRC E-Filing rule (72 FR 49139, August 28, 2007). The E-Filing process requires participants to submit... 2.311.\\3\\ \\3\\ Requesters should note that the filing requirements of the NRC's E-Filing Rule (72 FR... Power Resources, Inc., Smith Ranch Highland Uranium Project; License Renewal Request, Opportunity...

  17. LATTICE POLYMER AUTOMATA Steen RASMUSSEN a;b and Joshua R. SMITH b;c

    E-print Network

    LATTICE POLYMER AUTOMATA Steen RASMUSSEN a;b and Joshua R. SMITH b;c a TSA­DO/SA MS M997 and CNLS, the Lattice Polymer Automaton [LPA]. In the LPA all interactions, including electromagnetic forces, the molecular excluded volume forces, the longer range intermolecular forces, and the polymer

  18. 78 FR 44972 - George R. Smith, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-25

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Drug Enforcement Administration George R. Smith, M.D.; Decision and Order On February 5, 2013, Administrative Law Judge (ALJ) Gail A. Randall issued the attached Recommended Decision. Therein, the ALJ recommended that I deny Respondent's...

  19. Code Cache Management Schemes for Dynamic Optimizers Kim Hazelwood Michael D. Smith

    E-print Network

    Hazelwood, Kim

    Code Cache Management Schemes for Dynamic Optimizers Kim Hazelwood Michael D. Smith Division optimizer is a software-based system that performs code modifications at runtime, and several such systems of code. Since the dynamic optimizers produce variable-length code traces that are modified copies

  20. NOTES ON THE FLORIDA SPONGE FISHERY IN 1899. By HUGH M. SMITH.

    E-print Network

    NOTES ON THE FLORIDA SPONGE FISHERY IN 1899. By HUGH M. SMITH. The sponge fishery of Florida, Florida, a leading buyer and packer of Florida sponges. Key West and Tarpon Springs are now the only ports at which the cargoes of sponges are discharged and sold. At the former place in 1899 there were eight

  1. Katana: A Hot Patching Framework for ELF Executables Ashwin Ramaswamy, Sergey Bratus, Sean W. Smith

    E-print Network

    Smith, Sean W.

    Katana: A Hot Patching Framework for ELF Executables Ashwin Ramaswamy, Sergey Bratus, Sean W. Smith, and reliability, offline patching remains the predominant form of updating or protecting commodity software. Unfortunately, the mechanics of hot patching (the process of upgrading a program while it executes) remain

  2. Alteration of 'Granny Smith' Apple Peel Metabolic Profiles by Postharvest UV/Visable Irradiation

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Light exposure stimulates an array of responses in apple peel including photosynthesis and pigment metabolism. While the specifics of many metabolic processes stimulated by light are known, impacts of light on primary metabolism in apple peel are relatively uncharacterized. ‘Granny Smith’ apples, ...

  3. Hidden species complexes within distinctive taxa: the case of Epanthidium bicoloratum (Smith) (Hymenoptera: Megachilidae)

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Epanthidium bicoloratum (Smith) differs from all other Neotropical Anthidiini in the distinctive tegula, which is narrowed posteriorly forming a slender wedge. Examination of material standing under this name revealed that it represents a species complex that includes three new cryptic species, E. ...

  4. Production of 2n Pollen in Red Clover W. A. Parrott and R. R. Smith2

    E-print Network

    Parrott, Wayne

    Production of 2n Pollen in Red Clover W. A. Parrott and R. R. Smith2 ABSTRACT Thesuccessof.Diploidplantsthat produce2neggs are knownto occurin red clover, andplants that produce2npollen havebeenreported in red clover polyploidization programs. Additionalindexwords:Parallelspindles,Trifoliumpratense L

  5. Spatial Patterns and Size Distributions of Cities Wen-Tai Hsu Tomoya Mori Tony E. Smith

    E-print Network

    Smith, Tony E.

    the same statistical properties, each subset must exhibit essentially the same power law. Moreover Institute of Economy, Trade and Industry (RIETI) of Japan. Email: mori@kier.kyoto-u.ac.jp. Smith: Department regions and its mechanism: theory and evidence, undertaken at the Research Institute of Economy, Trade

  6. The Dependence of Bat Performance on Ball Properties Lloyd Smith and Joseph Duris

    E-print Network

    Smith, Lloyd V.

    The Dependence of Bat Performance on Ball Properties Lloyd Smith and Joseph Duris School of Physics University of Illinois, Urbana-Champaign, IL Nomenclature BBS Batted ball speed ea Apparent COR vp Ball pitch speed MOI Mass moment of inertia vi Inbound ball speed vb Bat speed at impact point COR

  7. Persistence of Infectious HIV on Follicular Dendritic Cells1 Beverly A. Smith,* Suzanne Gartner,

    E-print Network

    Burton, Greg F.

    Persistence of Infectious HIV on Follicular Dendritic Cells1 Beverly A. Smith,* Suzanne Gartner (FDCs) trap Ags and retain them in their native state for many months. Shortly after infection, HIV virus replication would replenish the HIV reservoir and thus falsely prolong recovery of infectious

  8. Mountain Precipitation and Hydrology in the Middle East Ronald. B. Smith*, Jason Evans*, Robert Oglesby**

    E-print Network

    Evans, Jason

    Mountain Precipitation and Hydrology in the Middle East Ronald. B. Smith*, Jason Evans*, Robert, the massive Zagros, Tauros and other mountain ranges in the Middle East exert a dominant control over, delaying and smoothing out the river discharge profile. Conversely, the mountains may also be partly

  9. 26. The StillwellBierce and SmithVaile Company, Dayton, Ohio, 13 April ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    26. The Stillwell-Bierce and Smith-Vaile Company, Dayton, Ohio, 13 April 1904 ELEVATION AND CUTAWAY DRAWINGS OF A TURBINE-GENERATOR UNIT IDENTICAL TO UNITS 4 AND 5 - Washington Water Power Company Monroe Street Plant, Units 4 & 5, South Bank Spokane River, below Monroe Street Bridge, Spokane, Spokane County, WA

  10. EFFECTS OF SOME TRACE ELEMENTS ON THE BLOOD OF KUWAIT MULLETS 'LIZA MACROLEPS' (SMITH)

    EPA Science Inventory

    Haemopathological changes attributed to heavy metal poisoning observed in blood smears of Liza macrolepis (Smith) taken after exposures of 96 h to graded doses (mg/l) of copper (0.11-1.80), lead (1.15-18.36), and mercury (0.04-0.59), in a flow-through marine bioassay system. In g...

  11. REMOTE SENSING (SUR 4380) Instructor: Scot E. Smith, Professor, Geomatics Program, School of Forest Resources and

    E-print Network

    Hill, Jeffrey E.

    REMOTE SENSING (SUR 4380) Instructor: Scot E. Smith, Professor, Geomatics Program, School of Forest:00-3:00 MWF Text: Remote Sensing and Image Interpretation by Lillesand, Kiefer and Chipman, 6th ed, Wiley and Sons, 2008. Course website: \\\\ad.ufl.edu\\ifas\\SFRC\\Private\\Geomatics\\Courses Topics: Remote sensing

  12. Melissa H.Dancy, Johnson C.Smith University Charles Henderson,Western Michigan University

    E-print Network

    Henderson, Charles

    Melissa H.Dancy, Johnson C.Smith University Charles Henderson,Western Michigan University Chandra #12;How can we increase the impact ofthe impact of Physics Education Research? #12;Pilot Work of time into it. #12;Faculty over report levels of knowledge and use. · Ideas often vague/general High

  13. Optical spectroscopy of tungsten carbide ,,WC... Shane M. Sickafoose, Adam W. Smith, and Michael D. Morse

    E-print Network

    Morse, Michael D.

    Optical spectroscopy of tungsten carbide ,,WC... Shane M. Sickafoose, Adam W. Smith, and Michael D transition-metal carbide, WC. A low-resolution scan revealed a five-member vibrational progression beginning to the isovalent molecule MoC and other transition-metal carbides. © 2002 American Institute of Physics. DOI: 10

  14. Properties of 2,2,2-trifluoroethanol and water mixtures Rajappa Chitra and Paul E. Smith

    E-print Network

    Smith, Paul E.

    Properties of 2,2,2-trifluoroethanol and water mixtures Rajappa Chitra and Paul E. Smith Department atomic level understanding of the properties of TFE/water mixtures. The trends in most properties of pure TFE are presented in Table I,7­26 together with the corresponding properties of water and ethanol

  15. fMRI measurements of color in macaque and human Smith-Kettlewell Eye Research Center,

    E-print Network

    Wandell, Brian A.

    fMRI measurements of color in macaque and human Smith-Kettlewell Eye Research Center, San Francisco Planck Institute for Biological Cybernetics, Tübingen, GermanyNikos Logothetis Psychology Department observations. Firstly, the relative amplitudes of responses to color and luminance stimuli in macaque area V1

  16. Classical Cryptographic Protocols in a Quantum World Sean Hallgren , Adam Smith , and Fang Song

    E-print Network

    Hallgren, Sean

    Classical Cryptographic Protocols in a Quantum World Sean Hallgren , Adam Smith , and Fang Song remains unchanged in a quantum world. 1 Introduction Cryptographic protocols, such as protocols for secure.S.A. Abstract. Cryptographic protocols, such as protocols for secure function evalu- ation (SFE), have played

  17. Classical Cryptographic Protocols in a Quantum World Sean Hallgren Adam Smith Fang Song

    E-print Network

    International Association for Cryptologic Research (IACR)

    Classical Cryptographic Protocols in a Quantum World Sean Hallgren Adam Smith § Fang Song ¶ Abstract Cryptographic protocols, such as protocols for secure function evaluation (SFE), have played a cru, deals almost exclusively with classical attackers. If we accept that quantum information processing

  18. Publications Princz, P., S. Smith, K. Hatfield and J. Olah. "Improvement of the Biological

    E-print Network

    Hill, Jeffrey E.

    Impacts of the Aswan High Dam: Prospects and Analysis", In: A Multidisciplinary Approach to Renewable. Rodriguez, S. Smith. "Socioeconomic Factors and Urban Tree Cover Policies in a Subtropical Urban Forest. Geo, B. "A Tool for Rapid Post-Hurricane Urban Tree Debris Estimates Using High Resolution Aerial Imagery

  19. EFFICIENCY TOOLS IN THE SPEECHES OF MARTIN LUTHER KING, JR. M. Cassandra Foster Smith

    E-print Network

    EFFICIENCY TOOLS IN THE SPEECHES OF MARTIN LUTHER KING, JR. M. Cassandra Foster Smith Computer of speeches of the Reverend Martin Luther King, Jr. Specif- ically, the analysis has investigated, Helloway 3, and Ohmann~ Martin Luther King, Jr. is considered by many to have been an effective speaker

  20. Gamma Rays from Lightning David M. Smith, Brian Grefenstette, Jacob Stanley,

    E-print Network

    California at Santa Cruz, University of

    Gamma Rays from Lightning David M. Smith, Brian Grefenstette, Jacob Stanley, SCIPP, U. C. Santa associated with thunderstorms & individual lightning flashes: Red sprites, sprite halos, blue jets: Elves (propagation of lightning to the ground) Any free electron gains enough energy between collisions to ionize

  1. 77 FR 64411 - Safety Zone; Cooper T. Smith Fireworks Event; Mobile River; Mobile, AL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-22

    ... Department of Homeland Security FR Federal Register NPRM Notice of Proposed Rulemaking COTP Captain of the... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Cooper T. Smith Fireworks Event; Mobile River; Mobile, AL AGENCY: Coast Guard, DHS. ] ACTION: Temporary final rule. SUMMARY: The Coast Guard...

  2. MASTER BATH. VIEW FACING EAST Camp H.M. Smith and ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    MASTER BATH. VIEW FACING EAST - Camp H.M. Smith and Navy Public Works Center Manana Title VII (Capehart) Housing, U-Shaped Three-Bedroom Duplex Type 2, Acacia Road, Birch Circle, and Cedar Drive, Pearl City, Honolulu County, HI

  3. Amphibian Resources on the Internet Michael W. Nolan and Stephen A. Smith

    E-print Network

    Boynton, Walter R.

    Amphibian Resources on the Internet Michael W. Nolan and Stephen A. Smith Abstract The use of amphibians in classrooms and research labora- tories has increased, along with a corresponding increase that the authors of this review cannot assure the accuracy of content in these web resources. Key Words: amphibian

  4. The Victorian Laptop: Narrative Engagement through Place and Time J. Cassell & J. Smith

    E-print Network

    Cassell, Justine

    The Victorian Laptop: Narrative Engagement through Place and Time J. Cassell & J. Smith MIT Media their experience and the story presented. These systems rely upon the narrative intelligence of humans to establish-person travelogues, which allows them to reflect on the connection between their own travel and the travel of others

  5. The sodium tail of the Moon M. Matta a,b,*, S. Smith a,1

    E-print Network

    Mendillo, Michael

    The sodium tail of the Moon M. Matta a,b,*, S. Smith a,1 , J. Baumgardner a,1 , J. Wilson a,1 , C 2009 Available online xxxx Keywords: Moon Meteors Solar wind Solar radiation Image processing a b s t r a c t During the few days centered about new Moon, the lunar surface is optically hidden from Earth

  6. Analysis of the Sensory Profile in Children with Smith-Magenis Syndrome

    ERIC Educational Resources Information Center

    Hildenbrand, Hanna L.; Smith, Ann C. M.

    2012-01-01

    This study systematically assessed sensory processing in 34 children, aged 3-14 years, with Smith-Magenis syndrome (SMS) using the Sensory Profile Caregiver Questionnaire. Scores for the SMS cohort were significantly different from scores of the national sample of children with and without disabilities in all Sensory Profile categories and…

  7. Biochemistry 1987, Jones, D. P., Thor, H., Smith, M. T., Jewell, S.A., & Orrenius,

    E-print Network

    Schnaufer, Achim

    Biochemistry 1987, Jones, D. P., Thor, H., Smith, M. T., Jewell, S.A., & Orrenius, S . (1983) J. 100, 95-97. Livesey, J. C., Anders, M. W., Langvardt, P. W., Putzig, C. L., & Reitz, R. H. (1982) Drug., Babson, J. R., Beatty, P. W., Brcdie, A. E., Ellis, W. W., & Potter, D. W. (1980) Anal.Biochem. 106, 55

  8. NMSU photo by Geraint Smith John T. Harrington Forestry Research Center at Mora

    E-print Network

    Johnson, Eric E.

    NMSU photo by Geraint Smith John T. Harrington Forestry Research Center at Mora Our mission. John T. Harrington Forestry Research Center at Mora New Mexico State University P.O. Box 359, Mora, NM the world in nursery production, forestry, and academia. · Produced over 200 publications, ranging from seed

  9. Book review Forestry and Climate Change, P.H. Freer-Smith, M.S.J.

    E-print Network

    Mencuccini, Maurizio

    Book review Forestry and Climate Change, P.H. Freer-Smith, M.S.J. Broadmeadow, J.M. Lynch, CAB, before 1997, that words such as land use, land use change and forestry would one day become the topic use of LULUCF (the acronym for Land Use, Land Use Change and Forestry, first used in the 2000 Special

  10. Smith Predictor Based Robot Control for Ultrasound-guided Teleoperated Beating-heart Surgery

    E-print Network

    1 Smith Predictor Based Robot Control for Ultrasound-guided Teleoperated Beating-heart Surgery, and the mean integrated square error. Index Terms--Beating-heart surgery, Robotic assistance, Ul- trasound, Member, IEEE, Abstract--Performing surgery on fast-moving heart structures while the heart is freely

  11. Alson H. Smith Jr. Agricultural Research and Extension Center Physical Resources

    E-print Network

    , and development of novel approaches to monitoring and managing pest species. Extension activities emphasize cost-effectiveAlson H. Smith Jr. Agricultural Research and Extension Center Physical Resources Land. Current research focused on the applied ecology and behavior of pest and beneficial insects

  12. Modeling the Effects of Prior Infection on Vaccine Efficacy y Derek J. Smith Stephanie Forrest

    E-print Network

    New Mexico, University of

    Modeling the Effects of Prior Infection on Vaccine Efficacy y Derek J. Smith Stephanie Forrest.lanl.gov Abstract We performed computer simulations to study the effects of prior infection on vaccine a prior infection or vaccination. The second antigen, the vaccine, represented a single component

  13. 78 FR 2295 - Charlissa C. Smith; Establishment of Atomic Safety and Licensing Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-10

    ... COMMISSION Charlissa C. Smith; Establishment of Atomic Safety and Licensing Board Pursuant to delegation by the Commission, see 37 FR 28,710 (Dec. 29, 1972), and the Commission's regulations, see 10 CFR Sec... rule, which the NRC promulgated in August 2007 (72 FR 49,139). Issued at Rockville, Maryland, this...

  14. Spin wave propagation in spatially nonuniform magnetic fields Kevin R. Smith,1,2,a

    E-print Network

    Spin wave propagation in spatially nonuniform magnetic fields Kevin R. Smith,1,2,a Michael J August 2008 Spin wave pulse propagation in a magnetic thin film under static, spatially nonuniform strip. Spin wave pulses were excited with a microstrip transducer at one end of the film strip. The spin

  15. Development and Behaviour in Marshall-Smith Syndrome: An Exploratory Study of Cognition, Phenotype and Autism

    ERIC Educational Resources Information Center

    van Balkom, I. D. C.; Shaw, A.; Vuijk, P. J.; Franssens, M.; Hoek, H. W.; Hennekam, R. C. M.

    2011-01-01

    Background: Marshall-Smith syndrome (MSS) is an infrequently described entity characterised by failure to thrive, developmental delay, abnormal bone maturation and a characteristic face. In studying the physical features of a group of patients, we noticed unusual behavioural traits. This urged us to study cognition, behavioural phenotype and…

  16. DIAGNOSIS OF CONDITIONAL MAXIMUM TORNADO DAMAGE PROBABILITIESP2.20 Bryan T. Smith1

    E-print Network

    DIAGNOSIS OF CONDITIONAL MAXIMUM TORNADO DAMAGE PROBABILITIESP2.20 Bryan T. Smith1 , Richard L between nontornadic and significant (> F2) tornado environments for supercells (e.g., Thompson et al. 2003 to the development of supercell ingredients-based composite parameters (i.e., significant tornado parameter, T03

  17. HOW BAT MODIFICATIONS CAN AFFECT THEIR RESPONSE L. V. SMITH AND C. CRUZ

    E-print Network

    Russell, Daniel A.

    HOW BAT MODIFICATIONS CAN AFFECT THEIR RESPONSE L. V. SMITH AND C. CRUZ Washington State University of players that compete in organized softball or baseball leagues use performance regulated bats. Some players attempt to gain a competitive edge by modifying their bats. The motivation to modify a bat has

  18. Describing the Performance of Cricket Bats and Balls Harsimranjeet Singh and Lloyd Smith

    E-print Network

    Smith, Lloyd V.

    Describing the Performance of Cricket Bats and Balls Harsimranjeet Singh and Lloyd Smith School-2920 USA Nomenclature: BBS Batted-ball speed DS Dynamic stiffness mb Cricket ball mass Fp Peak impact force vi Inbound ball speed ea Collision efficiency vb Cricket bat speed vp Cricket ball speed MOI Moment

  19. HOW BAT MODIFICATIONS CAN AFFECT THEIR RESPONSE LLOYD V. SMITH AND CURTIS M. CRUZ

    E-print Network

    Smith, Lloyd V.

    HOW BAT MODIFICATIONS CAN AFFECT THEIR RESPONSE LLOYD V. SMITH AND CURTIS M. CRUZ Washington State@kettering.edu The majority of players that compete in organized softball or baseball leagues use performance regulated bats. Some players attempt to gain a competitive edge by modifying their bats. The motivation to modify a bat

  20. "Comments on Coulter and Smith": Narrative Researchers as Witnesses of Injustice and Agents of Social Change?

    ERIC Educational Resources Information Center

    Barone, Tom

    2009-01-01

    In commenting on Coulter and Smith (2009), the author explores issues related to the place of the political in education research and in literature, but especially in forms of narrative research that possess both scientific and literary dimensions. More specifically, the author examines four sets of issues related to the researching and writing of…

  1. ESTIMATION OF SURPLUS BIOMASS OF CLUPEIDS IN SMITH MOUNTAIN LAKE, VIRGINIA

    EPA Science Inventory

    Mean annual estimates of surplus biomass of alewife Alosa pseudoharengus and gizzard shad Dorosoma cepedianum in Smith Mountain Lake, Virginia, were calculated using data on the biomass, growth, and mortality of each clupeid species. Surplus biomass, defined as production over a...

  2. H# Control Design for a Magnetostrictive Transducer James Nealis and Ralph C. Smith

    E-print Network

    H# Control Design for a Magnetostrictive Transducer James Nealis and Ralph C. Smith Center Magnetostrictive transducers are becoming increas­ ingly prevalent in industrial applications including high speed milling and hybrid motor design due to their broadband, large force capabilities. To achieve the level

  3. H Control Design for a Magnetostrictive Transducer James Nealis and Ralph C. Smith

    E-print Network

    . As detailed in [1, 2], these transducers possess the ability to generate broadband, high force responsesH Control Design for a Magnetostrictive Transducer James Nealis and Ralph C. Smith Center Magnetostrictive transducers are becoming increas- ingly prevalent in industrial applications including high speed

  4. Spotted gully shark (Triakis mega-lopterus, Smith, 1839), is one of five

    E-print Network

    101 Spotted gully shark (Triakis mega- lopterus, Smith, 1839), is one of five Triakis species, mortality, and demographic modeling of spotted gully shark (Triakis megalopterus) from the southeast coast, NOAA. Abstract--This study documents vali- dation of vertebral band-pair forma- tion in spotted gully

  5. A Test of Amino Acid Reversibility Nick G.C. Smith, Adam Eyre-Walker

    E-print Network

    Eyre-Walker, Adam

    A Test of Amino Acid Reversibility Nick G.C. Smith, Adam Eyre-Walker Centre for the Study no evidence to reject the assumption of reversibility in protein evolution. Key words: Amino acid evolution the evolution of proteins, it is generally assumed that the number of substitutions from amino acid X to amino

  6. Access Control Hygiene and the Empathy Gap in Medical IT Yifei Wang Sean Smith Andrew Gettinger

    E-print Network

    Access Control Hygiene and the Empathy Gap in Medical IT Yifei Wang Sean Smith Andrew Gettinger the enterprise and clinicians to regulatory and legal punishments). Access Control Hygiene In computer security passwords, post-it notes, and other circumvention. One researcher termed this the access control hygiene

  7. Access Control Hygiene and the Empathy Gap in Medical IT Yifei Wang Sean Smith Andrew Gettinger

    E-print Network

    Smith, Sean W.

    Access Control Hygiene and the Empathy Gap in Medical IT Yifei Wang Sean Smith Andrew Gettinger). Access Control Hygiene In computer security, access control addresses the problem of who can do what this the access control hygiene problem [2]. As literature reports (e.g., [8]) and as we have seen in our own

  8. Feb. 26, 2009 Susan Lampert Smith (608) 262-7335 ssmith5@uwhealth.org

    E-print Network

    Wisconsin at Madison, University of

    1 Feb. 26, 2009 Susan Lampert Smith (608) 262-7335 ssmith5@uwhealth.org Meditation in the Prisons: Can it make lasting change? MADISON -- Can meditation transform the hearts and minds of violent intensive meditation retreat offered at a U.S. prison. Panelists include Jenny Phillips, cultural

  9. Electromagnetic parameter retrieval from inhomogeneous metamaterials D. R. Smith,1,2,

    E-print Network

    Electromagnetic parameter retrieval from inhomogeneous metamaterials D. R. Smith,1,2, * D. C. Vier the validity of standard retrieval methods that assign bulk electromagnetic properties, such as the electric electromagnetic param- eters, even when there is significant inhomogeneity within the unit cell of the structure

  10. INFRARED LIGHT CURVES OF MIRA VARIABLE STARS FROM COBE DIRBE DATA Beverly J. Smith

    E-print Network

    Luttermoser, Donald G.

    INFRARED LIGHT CURVES OF MIRA VARIABLE STARS FROM COBE DIRBE DATA Beverly J. Smith Department of Physics and Astronomy, East Tennessee State University, Box 70652, Johnson City, TN 37614; smithbj@pari.edu and Donald Luttermoser Department of Physics and Astronomy, East Tennessee State University, Box 70652

  11. THE SOUTHERN SPRING MACKEREL FISHERY OF THE UNITED STATES. By HUGH M. SMITH.

    E-print Network

    THE SOUTHERN SPRING MACKEREL FISHERY OF THE UNITED STATES. By HUGH M. SMITH. The southern spring mackerel fishery of the United States if'! important from aev- eral standpoints, and of late has been than the regular fishery for mackerel carried on during the summer and fall months, it- has

  12. Quantitative phenotyping via deep barcode Andrew M. Smith,1,2,3

    E-print Network

    Roth, Frederick

    Methods Quantitative phenotyping via deep barcode sequencing Andrew M. Smith,1,2,3 Lawrence E collections in parallel. This method, Barcode analysis by Sequencing, or ``Bar-seq,'' outperforms the current benchmark barcode microarray assay in terms of both dynamic range and throughput. When applied to a complex

  13. Conservation rates: the best `new' source of urban water during William James Smith Jr.1

    E-print Network

    Delaware, University of

    of ecology and supply in the face of water scarcity will benefit from our analysis. Before proceeding to ourConservation rates: the best `new' source of urban water during drought William James Smith Jr.Ã1-side management; drought; environmental justice; sustainable development; water conservation; water rates; urban

  14. Improved Routing Wasps for Distributed Factory Control Vincent A. Cicirello and Stephen F. Smith

    E-print Network

    Cicirello, Vincent A.

    Improved Routing Wasps for Distributed Factory Control Vincent A. Cicirello and Stephen F. Smith approach to coordinating factory routing and scheduling based on a computational model of wasp behavior. The natural multi-agent sys- tem of the wasp colony is highly effective in self- organizing the allocation

  15. Prevalence, Phenomenology, Aetiology and Predictors of Challenging Behaviour in Smith-Magenis Syndrome

    ERIC Educational Resources Information Center

    Sloneem, J.; Oliver, C.; Udwin, O.; Woodcock, K. A.

    2011-01-01

    Background: The prevalence, phenomenology aetiology and correlates of four forms of challenging behaviour in 32 children and adults with Smith-Magenis syndrome (SMS) were investigated. Methods: Cognitive assessments, questionnaires and semi-structured interviews were used to gather data on intellectual disability, verbal and physical aggression,…

  16. Chemical composition and biological activity of the essential oil of rhizome of Zingiber zerumbet (L.) smith

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Technical Abstract: The aim was designed to study the biological activity and chemical composition of essential oil of Zingiber zerumbet (L.) Smith. The essential oil extracted from the rhizome of the plant was analysed by gas chromatography-mass spectroscopy and its major components amounting t...

  17. Human color vision and the unsaturated blue color of the daytime sky Glenn S. Smith

    E-print Network

    Wallin, David O.

    Human color vision and the unsaturated blue color of the daytime sky Glenn S. Smith Citation: Am. J://ajp.aapt.org/authors/copyright_permission #12;Human color vision and the unsaturated blue color of the daytime sky Glenn S. Smitha) School July 2004; accepted 10 December 2004 The usual answer to the question ``Why is the sky blue?'' is based

  18. Headed in the Right Direction: A Commentary on Yoshida and Smith

    ERIC Educational Resources Information Center

    Aslin, Richard N.

    2008-01-01

    Yoshida and Smith (this issue) provide one of the first attempts to overcome the most serious impediment to the use of head-mounted eye trackers with infants: Except in rare cases they are not light enough to be worn on an infant's head, or the infant does not tolerate looking through a half-silvered mirror that is hanging on a rigid stalk…

  19. Computing Privacy-Preserving Edit Distance and Smith-Waterman Problems on the GPU Architecture

    E-print Network

    International Association for Cryptologic Research (IACR)

    Computing Privacy-Preserving Edit Distance and Smith-Waterman Problems on the GPU Architecture Track: Cryptographic Technologies, Secure Compututation Shi Pu Department of Computer Science of Computer Science and Engineering Texas A&M University College Station, TX 77840 liu@cse.tamu.edu Abstract

  20. A Unified Model for Hysteresis in Ferroic Materials Ralph C. Smith

    E-print Network

    A Unified Model for Hysteresis in Ferroic Materials Ralph C. Smith , Stefan Seelecke , Marcelo J in hysteretic and nonlinear regimes. Whereas the physical mechanisms which produce hysteresis and constitutive. This unified methodology for quantifying hysteresis and constitutive nonlinearities for a broad class

  1. A Hysteresis Model for Piezoceramic Materials Ralph C. Smith Zoubeida Ounaies

    E-print Network

    A Hysteresis Model for Piezoceramic Materials Ralph C. Smith Zoubeida Ounaies Center for Research of nonlinear constitutive relations and hysteresis inherent to piezo­ ceramic materials at moderate to high that they exhibit nearly linear dynamics and minimal hysteresis at low drive levels. The restriction

  2. L1 Adaptive Control of Hysteresis in Smart Materials Xiang Fan and Ralph C. Smith

    E-print Network

    L1 Adaptive Control of Hysteresis in Smart Materials Xiang Fan and Ralph C. Smith Center behavior. Hence these mate- rials have inherent sensing and actuation capacities. However, the hysteresis compensation is a fundamental approach to cope with hysteresis, where one aims to cancel out the hysteresis

  3. A Parallel Java Grande Benchmark Suite L. A. Smith and J. M. Bull

    E-print Network

    Bull, Mark

    A Parallel Java Grande Benchmark Suite L. A. Smith and J. M. Bull EPCC, The King's Buildings Republic. email: xobdrzal@fi.muni.cz Abstract Increasing interest is being shown in the use of Java for large scale or Grande applications. This new use of Java places specific demands on the Java execution

  4. Smith-chart diagnostics for multi-GHz time-domain-reflectometry dielectric spectroscopy.

    PubMed

    Hager, N E; Domszy, R C; Tofighi, M R

    2012-02-01

    A time-domain-reflectometry Smith-chart display is demonstrated to be a valuable diagnostic tool in a variety of situations in time-domain-reflectometry dielectric spectroscopy. A relative reflection coefficient is formed by dividing the Laplace transform of the reflected sample transient by the Laplace transform of the empty-sensor transient and displaying in the complex plane, with the approximate sensor admittance read from susceptance and conductance circles. The Smith chart provides, as a diagnostic tool, an initial estimate of the dielectric behavior in the multi-GHz range and a means of identifying artifacts in acquisition and Laplace transform, in a way which does not require multiple steps of calibration and is only one step removed from the direct transient. Results are presented for a simple 3.5-mm flat sensor immersed in various liquid media, showing variations in the Smith chart for typical variations in sample permittivity, loss, and conductivity. Results are matched to vector network analyzer (VNA) measurement over an identical frequency range, as well as to finite-element field simulation. Results are also presented for a 3.5-mm sensor with various terminating pin lengths, typically employed at low frequencies and low permittivity media to increase sensor capacitance. For an unshielded pin, the Smith chart detects reflections from sample boundaries and measures the effectiveness of shielding used to eliminate these reflections. For a shielded pin, it characterizes the effect of pin length on the susceptance variation and the onset of pin resonance at high frequencies and high-permittivity values. The effect of artifacts appearing in the Smith chart on the actual calibration is shown by tracking them through the calibration process to the final result. Results are also presented for a 9-mm flat termination used for concrete hydration monitoring, showing effects of transmission-line discontinuities within a terminating plug and the onset of waveguide-like modes in a surrounding shield, with results compared to VNA measurement. PMID:22380126

  5. Smith-chart diagnostics for multi-GHz time-domain-reflectometry dielectric spectroscopy

    NASA Astrophysics Data System (ADS)

    Hager, N. E.; Domszy, R. C.; Tofighi, M. R.

    2012-02-01

    A time-domain-reflectometry Smith-chart display is demonstrated to be a valuable diagnostic tool in a variety of situations in time-domain-reflectometry dielectric spectroscopy. A relative reflection coefficient is formed by dividing the Laplace transform of the reflected sample transient by the Laplace transform of the empty-sensor transient and displaying in the complex plane, with the approximate sensor admittance read from susceptance and conductance circles. The Smith chart provides, as a diagnostic tool, an initial estimate of the dielectric behavior in the multi-GHz range and a means of identifying artifacts in acquisition and Laplace transform, in a way which does not require multiple steps of calibration and is only one step removed from the direct transient. Results are presented for a simple 3.5-mm flat sensor immersed in various liquid media, showing variations in the Smith chart for typical variations in sample permittivity, loss, and conductivity. Results are matched to vector network analyzer (VNA) measurement over an identical frequency range, as well as to finite-element field simulation. Results are also presented for a 3.5-mm sensor with various terminating pin lengths, typically employed at low frequencies and low permittivity media to increase sensor capacitance. For an unshielded pin, the Smith chart detects reflections from sample boundaries and measures the effectiveness of shielding used to eliminate these reflections. For a shielded pin, it characterizes the effect of pin length on the susceptance variation and the onset of pin resonance at high frequencies and high-permittivity values. The effect of artifacts appearing in the Smith chart on the actual calibration is shown by tracking them through the calibration process to the final result. Results are also presented for a 9-mm flat termination used for concrete hydration monitoring, showing effects of transmission-line discontinuities within a terminating plug and the onset of waveguide-like modes in a surrounding shield, with results compared to VNA measurement.

  6. The Adventures of Captain John Smith, Pocahontas and a Sundial: Cosmology, Mathematics, and Power at the Time of Jamestown

    NASA Astrophysics Data System (ADS)

    Schechner, Sara J.

    2007-12-01

    While exploring the Chickahominy River in Virginia by canoe in December 1607, Captain John Smith was ambushed by 200 Powhatan Indians and chased into the swamp. Wounded by arrows and mired in the cold mud, Smith surrendered and was led to their chieftain, Opechancanough. Smith played for time. He pulled out his pocket sundial and proceeded to deliver a lecture on astronomy. The Indians marveled at the dancing needle of the magnetic compass, which they could plainly see but not touch because of the glass cover. They apparently thought less of his discourse in a foreign language on the sun, moon, and planets, as within the hour, Smith's captors had him tied to a tree and were ready to shoot him. But then, Opechancanough held the sundial aloft and spared Smith's life. For the next month, Smith was paraded around various Indian villages before being condemned to have his head bashed in. Pocahontas, however, threw herself across Smith's body in order to save his life. This legendary episode reveals more than Smith's ingenuity. His compass sundial, shaped and marked like a celestial globe, was a microcosm of his universe. It embodied the belief that the smallest things mirrored the large, that number was the key to God's creation, and that by means of mathematical instruments, men could dominate that world (or at least extricate themselves from tight spots!). This paper will examine the astronomical ideas and instruments on which these beliefs were based, and show how ultimately, Smith's sundial also represented the clash of two cosmologies-that of the Indians and European settlers.

  7. Coherent and tunable light radiation from nanoscale surface plasmons array via an exotic Smith-Purcell effect.

    PubMed

    Liu, Weihao

    2015-10-15

    We demonstrate that surface plasmons on a nanoscale metallic array can be transformed into radiation waves via an exotic Smith-Purcell effect. Although the radiation frequency and direction satisfy the Smith-Purcell relation, it is coherent radiation with directions specified, which is essentially different from the ordinary Smith-Purcell radiation. Its radiation spectral density is an order of magnitude higher. By adjusting the material and structure of the array, the radiation frequency can be tuned from an infrared to ultraviolet region. Its remarkable advantages in intensity, coherence, tunability, and miniature size indicate new prospects in developing nanoscale light sources and related techniques. PMID:26469568

  8. ERNEST M. WRIGHT FRS Distinguished Professor of Physiology

    E-print Network

    Wright, Ernest

    's College, London 1989 Walter B. Cannon Lecturer, American Physiological Society 1989 Smith, Kline was born in Belfast, N. Ireland and educated in Ulster and England. He earned his B.Sc. in Physiology

  9. Nonlinear Pricing in Markets with Interdependent Demand Author(s): Shmuel S. Oren, Stephen A. Smith and Robert B. Wilson

    E-print Network

    Oren, Shmuel S.

    and Robert B. Wilson Reviewed work(s): Source: Marketing Science, Vol. 1, No. 3 (Summer, 1982), pp. 287 S. OREN, t STEPHEN A. SMITH, t AND ROBERT B. WILSON? This paper provides a mathematical framework

  10. 76 FR 55413 - Proposed Safe Harbor Agreement for California Red-legged Frog, California Tiger Salamander, Smith...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-07

    ...Harbor Agreement for California Red-legged Frog, California Tiger Salamander, Smith's...federally threatened California red-legged frog (Rana draytonii) and California tiger...conservation of the California red-legged frog, California tiger salamander,...

  11. Charla con el doctor Thomas Smith sobre el creciente papel de los cuidados paliativos en los pacientes con cáncer

    Cancer.gov

    El doctor Thomas J. Smith, director de cuidados paliativos del Centro Oncológico Integral Johns Hopkins Sidney Kimmel, responde a preguntas sobre el creciente papel de los cuidados paliativos en la práctica oncológica.

  12. 77 FR 26733 - Uinta-Wasatch-Cache National Forest; Evanston-Mountain View Ranger District; Utah; Smiths Fork...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-07

    ...Uinta-Wasatch-Cache National Forest; Evanston-Mountain View Ranger District; Utah; Smiths...SUMMARY: The Evanston-Mountain View Ranger District of the Uinta- Wasatch-Cache...approximately 25 miles southwest of Mountain View, Wyoming. Proposed treatment...

  13. 77 FR 34337 - Uinta-Wasatch-Cache National Forest; Evanston-Mountain View Ranger District; Utah; Smiths Fork...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-11

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF AGRICULTURE Forest Service Uinta-Wasatch-Cache National Forest; Evanston-Mountain View Ranger District; Utah; Smiths... format. FOR FURTHER INFORMATION CONTACT: Pete Gomben, Environmental Coordinator for the...

  14. 78 FR 66748 - Smith Miller and Patch Inc. et al.; Proposal to Withdraw Approval of 14 New Drug Applications...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-06

    ... Required Reports Have Not Been Made Application No. Drug Applicant NDA 004979 Multi-Vitamin Smith Miller...) Tablets. NDA 008326 Methischol (inositol/ USV Pharmaceutical vitamin B12/ Corp., 500...

  15. 76 FR 59115 - Notice of Availability of Patent Fee Changes Under the Leahy-Smith America Invents Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-23

    ...DEPARTMENT OF COMMERCE Patent and Trademark Office [Docket No. PTO-P-2011-0049] Notice of Availability of Patent Fee Changes Under the Leahy- Smith America Invents Act AGENCY: United States Patent and Trademark Office, Commerce....

  16. 77 FR 442 - Changes To Implement Miscellaneous Post Patent Provisions of the Leahy-Smith America Invents Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-05

    ...DEPARTMENT OF COMMERCE United States Patent and Trademark Office 37 CFR Part 1...Changes To Implement Miscellaneous Post Patent Provisions of the Leahy-Smith America Invents Act AGENCY: United States Patent and Trademark Office, Commerce....

  17. 77 FR 46615 - Changes To Implement Miscellaneous Post Patent Provisions of the Leahy-Smith America Invents Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-06

    ...DEPARTMENT OF COMMERCE United States Patent and Trademark Office 37 CFR Parts 1...Changes To Implement Miscellaneous Post Patent Provisions of the Leahy-Smith America Invents Act AGENCY: United States Patent and Trademark Office, Commerce....

  18. 78 FR 66748 - Smith Miller and Patch Inc. et al.; Proposal to Withdraw Approval of 14 New Drug Applications...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-06

    ...NDA 004979.................. Multi-Vitamin Smith Miller and Tablets. Patch Inc., P.O. Box 367...Methischol (inositol/ USV Pharmaceutical vitamin B12/ Corp., 500 Virginia racemethionine/ Dr., Fort...

  19. Density Functional study of Wigner-Smith time delays in photoionization and photorecombination of argon

    NASA Astrophysics Data System (ADS)

    Magrakvelidze, Maia; Madjet, Mohamed; Dixit, Gopal; Ivanov, Misha; Chakraborty, Himadri

    2015-05-01

    We investigate quantum phases and Wigner-Smith time delays in photoionization and photorecombination of valence electrons of argon using Kohn-Sham time-dependent local density approximation (TDLDA) with the Leeuwen and Baerends exchange-correlation functional. Numerical results for the phases at respective 3p and 3s Cooper minima show opposite variations resulting from the correlation that is based on mutual couplings between 3p and 3s channels. Computed attosecond Wigner-Smith time delays show excellent agreements with two recent independent experiments on argon that measured the relative 3s-3p time delay in photoionization and the delay in 3p photorecombination. This work was supported by the U.S. National Science Foundation.

  20. Adam Smith and Social Justice: the Ethical Basis of the Weath of Nations

    E-print Network

    Ossar, Jacob

    without happiness. 2 3 WN I.viii.28-WN I.viii.35 (pp. 91-96). 2 4WNI.viii36(pg.96). 2 5 TMS HI.3.9 (pg. 139). 2 6TMS HI.3.9 (pg. 140). ADAM SMITH AND SOCIAL JUSTICE 131 can produce only anxiety to ourselves, without any manner of advantage to them... 7 TMS Il.ii.2.1 (pg. 82). Note here that Smith assumes that what is natura is what is good. Like his friend David Hume, he is generally very carefu not to reason from is to ought. 28TMSVI.ii.3.6(pg.237). 2 9TMSILi.l.9(pg.82). 3 0TMSIUU5(pg.79...

  1. Granny Smith diopside megacrysts from the kimberlites of the Kimberley area and Jagersfontein, South Africa

    NASA Astrophysics Data System (ADS)

    Boyd, F. R.; Dawson, J. B.; Smith, J. V.

    1984-02-01

    Calcic diopside megacrysts, called Granny Smith nodules, in the Kimberley area and Jagersfontein kimberlites are sheared, commonly contain lenticles of ilmenite and intergrowths of phlogopite, and have a distinctive apple-green color. These diopsides have Ca/(Ca + Mg) > 0.45, Mg/(Mg + Fe) > 0.90, 0.2-0.4 wt% TiO 2 and 0.5-3 wt% Cr 2O 3. They have Na > ( Al + Cr), in contrast to diopsides in peridotite xenoliths and those that form subcalcic discrete nodules, but in this respect are similar to diopsides in amphibole-bearing MARID nodules and mica-rich glimmerites. Granny Smith megacrysts are not cognate ( Kramers, 1979); their parental magmas (in an igneous or metasomatic sense) may have been parts of the spectrum between kimberlites and lamproites.

  2. Structured multidisciplinary intershift handover (SMITH): a tool for promoting safer intrapartum care.

    PubMed

    Edozien, L C

    2011-11-01

    On the labour ward, the key to achieving patient safety is the intershift handover, which affords an opportunity for the team to undertake a baseline assessment of the current situation, anticipate problems, plan contingencies and subsequently maintain situational awareness. If optimised, the handover has immense potential not only for enhancing patient safety but also for reducing stress to staff. The handover should be regarded not as an end but as the beginning of the process of maintaining individual and team situational awareness throughout the shift. Each maternity unit should have a Structured Multidisciplinary Intershift Handover (SMITH) protocol, which encompasses pre-handover, handover and post-handover guidance. This paper describes the underlying principles, benefits and content of a SMITH protocol. PMID:22085053

  3. Statistical distribution of the Wigner-Smith time-delay matrix moments for chaotic cavities

    E-print Network

    Fabio Deelan Cunden

    2015-06-16

    We derive the joint distribution of the moments $\\mathrm{Tr}\\, Q^{\\kappa}$ ($\\kappa\\geq0$) of the Wigner-Smith matrix for a chaotic cavity supporting a large number of scattering channels $n$. This distribution turns out to be asymptotically Gaussian, and we compute explicitly averages and covariances. The results are in a compact form and have been verified numerically. The general methodology of proof and computations has a wide range of applications.

  4. THE SMITH NORMAL FORM OF A SPECIALIZED JACOBI-TRUDI RICHARD P. STANLEY

    E-print Network

    (SNF) of M. In general, the SNF does not exist. It does exist when R is a principal ideal domain (PID in this paper). Over a PID the SNF is unique up to multiplication of diagonal elements by units in R. Note to consider the SNF. There has been a lot of recent work, such as [1][5], on the Smith normal form of spe

  5. The Smith Normal Form of a Matrix Associated with Young's Lattice

    E-print Network

    be a commutative ring with 1 and M an m×m matrix over R. We say that M has a Smith normal form (SNF) over R and if the SNF of M exists, then it is unique up to multiplication of each di by a unit ui (with u1 · · · um = 1[x] of integer polynomials in one variable. Since Z[x] is not a PID, a matrix over this ring need not have an SNF

  6. Energy conservation study on Smith Frozen Foods processing plant, Weston, Oregon

    SciTech Connect

    Not Available

    1985-01-02

    A comprehensive energy study was performed at Smith Frozen Foods in Weston, Oregon, in the fall of 1984. The plant processes corn, peas, lima beans and carrots. The products are inspected, prepared and graded before being sent through freeze tunnels. The frozen products are dumped into tote bins which are transported into cold storage warehouses. Energy conservation measures were calculated using a modified return on investment analysis called a return on capital (ROC) analysis and current rate schedules.

  7. Statistical distribution of the Wigner-Smith time-delay matrix moments for chaotic cavities

    NASA Astrophysics Data System (ADS)

    Cunden, Fabio Deelan

    2015-06-01

    We derive the joint distribution of the moments Tr Q?(? ?1 ) of the Wigner-Smith matrix for a chaotic cavity supporting a large number of scattering channels n . This distribution turns out to be asymptotically Gaussian, and we compute explicitly averages and covariances. The results are in a compact form and have been verified numerically. The general methodology of proof and computations has a wide range of applications.

  8. Additional dates of Sir Andrew Smith's Illustrations of the Zoology of South Africa.

    PubMed

    Low, Martyn E Y; Evenhuis, Neal L

    2014-01-01

    We update the collation of the dates of publication of Smith's Illustrations of the Zoology of South Africa provided by Waterhouse (1880) and Barnard (1950, 1952). In the case of nine parts, we are able to provide more accurate dates of publication (including day-dates for seven of these parts). For workers of invertebrate taxonomy, we provide an accurate date of publication for W. S. Macleay's volume on Annulosa.  PMID:24870491

  9. Smith degradation, an efficient method for the preparation of cycloastragenol from astragaloside IV.

    PubMed

    Feng, Lin-min; Lin, Xiong-hao; Huang, Fei-xia; Cao, Jing; Qiao, Xue; Guo, De-an; Ye, Min

    2014-06-01

    Cycloastragenol (CA) is the genuine sapogenin of astragaloside IV (ASI). This study focuses on the preparation of CA from ASI. Five hydrolysis methods were compared including H2SO4 hydrolysis, HCl hydrolysis, two-phase acid hydrolysis, mild acid hydrolysis, and Smith degradation. Seven hydrolysis products were purified, and five of them were identified as new compounds. The results indicated that Smith degradation was the most effective approach to prepare CA. In contrast, mild acid hydrolysis produced CA at a low yield, accompanied with the artificial sapogenin astragenol. The other three acid hydrolysis methods mainly produced astragenol. Furthermore, the reaction conditions for Smith degradation were optimized as follows: ASI was dissolved in 60% MeOH-H2O solution, oxidized with 5 equiv. NaIO4 for 12h, followed by reduction with 3 equiv. NaBH4 for 4h, and finally acidified with 1M H2SO4 at pH2 for 24h. Under the optimal conditions, CA could be prepared from ASI at a yield of 84.4%. PMID:24613799

  10. William Peirce and E.A. Cappelen Smith and their amazing copper converting machine

    NASA Astrophysics Data System (ADS)

    Southwick, Larry M.

    2008-10-01

    This is the story of how technology advances allowed the copper industry to realize its full potential. The Peirce-Smith Converting Centennial symposium, to be held at the TMS 2009 Annual Meeting, will celebrate the contributions of two men, William Peirce and E.A.C. Smith, in these advances. However, theirs is representative of a larger story: New, simpler technology releasing the stranglehold of older, more complicated technology, new developments in vessel configuration and design finding alternate routes around dead ends in operability, advances in technique and concepts removing roadblocks of cycle time and capacity, and overall innovation opening up vast new reserves around the world to those companies willing to embrace those improvements. Our story is also one of personalities, stubborn smeltermen versus the innovators, those inside the industry versus those from outside. It is a story of an initial borrowing from the steel industry, but also Peirce and Smith, from the refining end of the copper business, taking the ideas of Baggaley from Pittsburgh’s steel and air-brake industry, who built on what Hollway, Manhès and David, Douglas, and others had done in smelter tests, further to compete with the previous primacy and closely held expertise of the copper smeltermen in Wales. The photos presented illustrate these innovations.

  11. Acceleration of the Smith-Waterman algorithm using single and multiple graphics processors

    NASA Astrophysics Data System (ADS)

    Khajeh-Saeed, Ali; Poole, Stephen; Blair Perot, J.

    2010-06-01

    Finding regions of similarity between two very long data streams is a computationally intensive problem referred to as sequence alignment. Alignment algorithms must allow for imperfect sequence matching with different starting locations and some gaps and errors between the two data sequences. Perhaps the most well known application of sequence matching is the testing of DNA or protein sequences against genome databases. The Smith-Waterman algorithm is a method for precisely characterizing how well two sequences can be aligned and for determining the optimal alignment of those two sequences. Like many applications in computational science, the Smith-Waterman algorithm is constrained by the memory access speed and can be accelerated significantly by using graphics processors (GPUs) as the compute engine. In this work we show that effective use of the GPU requires a novel reformulation of the Smith-Waterman algorithm. The performance of this new version of the algorithm is demonstrated using the SSCA#1 (Bioinformatics) benchmark running on one GPU and on up to four GPUs executing in parallel. The results indicate that for large problems a single GPU is up to 45 times faster than a CPU for this application, and the parallel implementation shows linear speed up on up to 4 GPUs.

  12. Measuring flushing symptoms with extended-release niacin using the flushing symptom questionnaire©: results from a randomised placebo-controlled clinical trial

    PubMed Central

    Paolini, J F; Mitchel, Y B; Reyes, R; Thompson-Bell, S; Yu, Q; Lai, E; Watson, D J; Norquist, J M; McCrary Sisk, C; Bays, H E

    2008-01-01

    Introduction Niacin is underutilised because of flushing. Lack of a quantitative tool to assess niacin-induced flushing has precluded the objective evaluation of flushing associated with extended-release (ER) niacin formulations. We developed the Flushing Symptom Questionnaire© (FSQ), a quantitative tool to assess patient-reported flushing, and assessed its ability to characterise ER niacin-induced flushing. Methods This study focused on the responses to one question in the FSQ, the Global Flushing Severity Score (GFSS), reported on a 0–10 scale (none = 0, mild = 1–3, moderate = 4–6, severe = 7–9 and extreme = 10) to assess flushing during ER niacin initiation (week 1) and maintenance (weeks 2–8). Results Flushing severity with ER niacin was greatest during week 1 and remained greater than placebo for the study duration. During weeks 2–8, 40% of patients on ER niacin vs. 8% of those on placebo had > 1 day/week with ‘moderate or greater’ GFSS. Conclusions In conclusion, the GFSS component of the FSQ was a sensitive and responsive quantitative measure of ER niacin-induced flushing that will aid in the objective comparison of novel strategies intended to improve tolerability and adherence to niacin, an agent proven to reduce cardiovascular risk. Disclosures John F. Paolini, Yale B. Mitchel, Robert Reyes, Sally Thompson-Bell, Qinfen Yu, Eseng Lai, Douglas J. Watson, Josephine M. Norquist and Christine McCrary Sisk are employees of Merck & Co., Inc., and may own stock/hold stock options in the Company. Dr Harold Bays has served as a Clinical Investigator for (and has received research grants from) the following: Abbott, Alteon, Arena, AstraZeneca, Aventis, Bayer, Boehringer Ingelheim, Boehringer Mannheim, Bristol Myers Squibb, Ciba Geigy, Eli Lilly, Esperion, Fujisawa, GelTex, Genentech, GlaxoSmithKline, Hoechst Roussel, Hoffman LaRoche, InterMune, KOS, Kowa, Lederle, Marion Merrell Dow, Merck, Merck Schering Plough, Miles, Novartis, Parke Davis, Pfizer, Pliva, Purdue, Reliant, Roche, Rorer, Regeneron, Sandoz, Sankyo, Sanofi, Searle, Shionogi, Schering Plough, SmithKline Beacham, Takeda, TAP, UpJohn, Upsher Smith, Warner Lambert and Wyeth-Ayerst. He has also served as a consultant, speaker, and/or advisor to and for Arena, AstraZeneca, Aventis, Bayer, Bristol Myers Squibb, KOS, Merck, Merck Schering Plough, Metabasis Therapeutics, Microbia, Novartis, Nicox, Ortho-McNeil, Parke Davis, Pfizer, Roche, Sandoz, Sankyo, Sanofi Aventis, Shering Plough, SmithKline Beacham, Takeda, UpJohn and Warner Lambert. What's known Niacin has favourable effects on the lipid profile; however, its use in clinical practice has been hampered by bothersome side effects, primarily flushing. The lack of a quantitative tool to assess flushing symptoms has precluded the objective evaluation of niacin-induced flushing. What's new This study describes the utility of the Flushing Symptom Questionnaire© (FSQ), a quantitative tool to assess patient-reported flushing end-points. The results show that the FSQ is a useful patient-reported outcome measure to objectively assess flushing associated with extended-release niacin. PMID:18410350

  13. The education and medical practice of Dr. James McCune Smith (1813-1865), first black American to hold a medical degree.

    PubMed Central

    Morgan, Thomas M.

    2003-01-01

    James McCune Smith (1813-1865)--first black American to obtain a medical degree, prominent abolitionist and suffragist, compassionate physician, prolific writer, and public intellectual--has been relatively neglected by historians of medicine. No biography of Smith exists to this day, though he has been the subject of several essays. Born, in his own words, "the son of a self-emancipated bond-woman," and denied admission to colleges in the United States, his native land, Smith earned medical, master's, and baccalaureate degrees at Glasgow University in Scotland. On his return to New York City in 1837, Smith became the first black physician to publish articles in US medical journals. Smith was broadly involved in the anti-slavery and suffrage movements, contributing to and editing abolitionist newspapers and serving as an officer of many organizations for the improvement of social conditions in the black community. In his scientific writings Smith debunked the racial theories in Thomas Jefferson's Notes on the State of Virginia, refuted phrenology and homeopathy, and responded with a forceful statistical critique to the racially biased US Census of 1840. Frederick Douglass, Gerrit Smith, and John Brown personally collaborated with James McCune Smith in the fight for black freedom. As the learned physician-scholar of the abolition movement, Smith was instrumental in making the overthrow of slavery credible and successful. Images Figure 1 PMID:12911258

  14. Calculation of force and power during bench throws using a Smith machine: the importance of considering the effect of counterweights.

    PubMed

    Kobayashi, Y; Narazaki, K; Akagi, R; Nakagaki, K; Kawamori, N; Ohta, K

    2013-09-01

    For achieving accurate and safe measurements of the force and power exerted on a load during resistance exercise, the Smith machine has been used instead of free weights. However, because some Smith machines possess counterweights, the equation for the calculation of force and power in this system should be different from the one used for free weights. The purpose of this investigation was to calculate force and power using an equation derived from a dynamic equation for a Smith machine with counterweights and to determine the differences in force and power calculated using 2 different equations. One equation was established ignoring the effect of the counterweights (Method 1). The other equation was derived from a dynamic equation for a barbell and counterweight system (Method 2). 9 female collegiate judo athletes performed bench throws using a Smith machine with a counterweight at 6 different loading conditions. Barbell displacement was recorded using a linear position transducer. The force and power were subsequently calculated by Methods 1 and 2. The results showed that the mean and peak power and force in Method 1 were significantly lower relative to those of Method 2 under all loading conditions. These results indicate that the mean and peak power and force during bench throwing using a Smith machine with counterweights would be underestimated when the calculations used to determine these parameters do not account for the effect of counterweights. PMID:23459856

  15. Theobald Smith--the discoverer of ticks as vectors of disease.

    PubMed

    Assadian, Ojan; Stanek, Gerold

    2002-07-31

    The cause of Texas fever in cattle, which is characterised by lysis of erythrocytes leading to anaemia, icterus, haemoglobinuria, and death, remained unsolved for many decades and assorted theories were proposed as an explanation for a disease being transmitted by apparently healthy animals. From 1889 to 1893, Theobald Smith and Frederick L. Kilbourne could demonstrate in elegantly conducted experiments how the disease was spread from cattle to cattle by ticks serving as the vector of transmission. Furthermore, they were able to identify the pathogen of Texas fever, an intra-erythrocytic protozoan which Smith named Pyrosoma bigeminum. Today it is recognised that either of two species of the now renamed genus Babesia, Babesia bigemina and Babesia bovis, may be involved in Texas fever and that babesiosis is generally transmitted by ticks. In animals, genera like Boophilus spp., Dermacentor spp. and Rhipicephalus spp. are possible vectors. The first case of tick-transmitted babesiosis in a human was reported by Skrabalo and Deanovic in 1957 and occurred near Ljubliana in the small town of Strmec, Croatia. In humans, the vectors of most reported cases are ticks of the genus Ixodes, which are among the most predominant ticks in Austria. However, cases of human babesiosis in Austria remain to be studied. Smith and Kilbourne's work was the first demonstration that ticks transmit disease of any kind. Furthermore, by proving that ticks carry Babesia microti--which causes babesiosis in animals and humans--this is the first account of a zoonotic disease and the foundation of all later work on the animal host and the arthropod vector. PMID:12422586

  16. Graphene on nanoscale gratings for the generation of terahertz Smith-Purcell radiation

    SciTech Connect

    Tantiwanichapan, Khwanchai; Wang, Xuanye; Swan, Anna K.; Paiella, Roberto

    2014-12-15

    Generation of THz radiation based on the Smith-Purcell effect in graphene is investigated numerically. The specific device geometry considered involves an electrically biased single-layer sheet of graphene deposited on a periodic array of holes in a solid substrate. Rigorous electrodynamic simulations combined with a basic model of charge transport are presented, showing that technologically significant output power levels can be obtained at geometrically tunable THz frequencies. These results suggest that graphene is a uniquely suited materials platform for the demonstration of THz electron-beam radiation mechanisms in compact solid-state systems.

  17. Enhance the terahertz Smith-Purcell superradiant radiation by using dielectric loaded grating

    NASA Astrophysics Data System (ADS)

    Cao, Miaomiao; Liu, Wenxin; Wang, Yong; Li, Ke

    2015-08-01

    A dielectric loaded grating (DLG) for terahertz Smith-Purcell (SP) device is proposed to enhance the radiation intensity. By using the theoretical analysis and particle-in-cell simulations, the dispersion characteristics and SP superradiant radiation are investigated. Compared with the general metal grating, the usage of DLG can improve the magnitude of electric field and, consequently, strengthen the interaction of the evanescent wave with electron beam, which can improve the growth rate, enhance the SP superradiant radiation, and lower the start current for the operation of SP free-electron laser.

  18. Smith Newton Vehicle Performance Evaluation – Cumulative; Vehicle Technologies Office (VTO), Energy Efficiency & Renewable Energy (EERE)

    SciTech Connect

    2013-10-01

    The Fleet Test and Evaluation Team at the U.S. Department of Energy's National Renewable Energy Laboratory is evaluating and documenting the performance of electric and plug-in hybrid electric drive systems in medium-duty trucks across the nation. U.S. companies participating in this evaluation project received funding from the American Recovery and Reinvestment Act to cover part of the cost of purchasing these vehicles. Through this project, Smith Electric Vehicles is building and deploying 500 all-electric medium-duty trucks that will be deployed by a variety of companies in diverse climates across the country.

  19. Smith Newton Vehicle Performance Evaluation - Gen2 - 1Q2014 (Brochure)

    SciTech Connect

    Not Available

    2014-04-01

    The Fleet Test and Evaluation Team at the U.S. Department of Energy's National Renewable Energy Laboratory is evaluating and documenting the performance of electric and plug-in hybrid electric drive systems in medium-duty trucks across the nation. U.S. companies participating in this evaluation project received funding from the American Recovery and Reinvestment Act to cover part of the cost of purchasing these vehicles. Through this project, Smith Electric Vehicles is building and deploying 500 all-electric medium-duty trucks that will be deployed by a variety of companies in diverse climates across the country.

  20. Smith Newton Vehicle Performance Evaluation – 4th Quarter 2013; NREL (National Renewable Energy Laboratory)

    SciTech Connect

    2014-01-01

    The Fleet Test and Evaluation Team at the U.S. Department of Energy's National Renewable Energy Laboratory is evaluating and documenting the performance of electric and plug-in hybrid electric drive systems in medium-duty trucks across the nation. U.S. companies participating in this evaluation project received funding from the American Recovery and Reinvestment Act to cover part of the cost of purchasing these vehicles. Through this project, Smith Electric Vehicles is building and deploying 500 all-electric medium-duty trucks that will be deployed by a variety of companies in diverse climates across the country.