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1

Scientists in Sport, the 2012-Inspired GlaxoSmithKline Schools Outreach Programme  

ERIC Educational Resources Information Center

The GlaxoSmithKline Scientists in Sport team have worked with 4science to provide resources and offer activities for use by schools to show the relevance of science in sport. Much of the content looks at anti-doping and the science involved with detecting the misuse of banned substances. Through the development of a website, this work can continue…

Gadd, Mark

2012-01-01

2

Epristeride SmithKline Beecham.  

PubMed

Epristeride is a transition-state, noncompetitive steroid 5-alpha-reductase inhibitor under development by SmithKline Beecham for the treatment of benign prostatic hyperplasia and acne. Phase III trials for prostatic hypertrophy with an oral formulation, have been initiated in the UK, the US and Japan [188478], [219166]. In healthy male volunteers, epristeride caused a reduction in serum dihydrotestosterone levels but serum testos-terone levels remained stable. In animal studies, it showed a similar potency to finasteride for the inhibition of 5-alpha-reductase [164200]. Epristeride is licensed to Ono which has exclusive rights in Japan, South Korea and Taiwan. Recordati has co-marketing rights for epristeride [162547], [162519]. Analysts at Yamaichi estimate that epristeride will be launched in Japan between 1999 and 2000 and peak annual sales have been predicted to be over ten billion Yen [216018]. PMID:18465521

Hedge, S S

1998-05-01

3

SmithKline Beecham Biologicals Worldwide Vaccines  

NSDL National Science Digital Library

This new site from SmithKline Beecham, a "virtual gateway into the world of vaccinology," offers a host of resources on vaccination and vaccine preventable diseases. These resources are organized in three principle sections: Disease, Bio News, and Links. The first and largest section contains various reference resources for ten different diseases or disease groups, which are listed in four columns: disease, virus, epidemiology, and prevention. Although a public site, much of this information is aimed at physicians, health professionals, or other informed users. The Bio News section offers a selection of recent and archived scientific published data from peer-reviewed journals, a select list of links for breaking health news, and recent SmithKline Beecham vaccine press releases. A collection of related annotated links, sorted by country, rounds out the site. An additional site for registered medical professionals only is also available, and these users may log on via the public site. Please note that the site authors indicate that "This site is not intended for US audiences."

4

78 FR 63226 - GlaxoSmithKline LLC; Withdrawal of Approval of the Indication for Treatment of Patients With...  

Federal Register 2010, 2011, 2012, 2013, 2014

...rituximab, for BEXXAR (tositumomab and iodine I 131 tositumomab) Injection held by...indication for BEXXAR (tositumomab and iodine I 131 tositumomab) Injection because...indication for BEXXAR (tositumomab and iodine I 131 tositumomab) Injection from...

2013-10-23

5

Our Client, GlaxoSmithKline is one of the world's leading research-based pharmaceutical companies. With 90000 employees world-wide, the company is  

E-print Network

are: Thrilled by mobile apps! Love to develop mobile applications for iOS and Android! Like and is looking for motivated professionals to join the team at the position of: Mobile applications developer You to experience new mobile development platforms! The role: Develops mobile applications for various GSK

Kasparian, Azniv

6

Christos Chatziantoniou, directeur de recherche l'Inserm, laurat du Discovery Fast Track Challenge 2014, organis par GlaxoSmithKline  

E-print Network

traitement aujourd'hui contre la phase terminale de la maladie rénale sont la dialyse ou une transplantation travaux dans le domaine de l'insuffisance rénale chronique, figure parmi les 14 lauréats de cet appel à programmes menant au développement de médicaments innovants contre l'insuffisance rénale chronique (IRC). La

7

Feasibility Study of GlaxoSmithKline Biologicals' GSK2202083A Vaccine in Healthy Infants at 3, 5 and 11 Months of Age.  

ClinicalTrials.gov

Haemophilus Influenzae Type b; Poliomyelitis; Hepatitis B; Serogroup C Meningococcal Diseases; Diphtheria; Pertussis; Diphtheria-Tetanus-aPertussis-Hepatitis B-Poliomyelitis-Haemophilus Influenzae Type b-Neisseria Meningitidis Vaccines; Tetanus

2012-11-16

8

La infeccin por el VIH y su tratamiento Medicamentos contra el VIH aprobados por la FDA  

E-print Network

Emtricitabina (FTC) Emtriva Gilead Sciences 2 julio 2003 Lamivudina (3TC) Epivir GlaxoSmithKline 17 noviembre) (TDF) Viread Gilead Sciences 26 octubre 2001 Zidovudina (ZDV,AZT) Retrovir GlaxoSmithKline 19 marzo

Levin, Judith G.

9

Exact Kinetic Analysis of Passive Transport across a Polarized Confluent MDCK Cell Monolayer Modeled as a Single Barrier  

E-print Network

of Prussia, Pennsylvania 4 Preclinical Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research & Biotechnology, Drexel University, Philadelphia, Pennsylvania 19104 2 Preclinical Drug Metabolism Triangle Park, North Carolina 5 Preclinical Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Welwyn

Mittal, Aditya

10

The Elementary Mass Action Rate Constants of P-gp Transport for a Confluent Monolayer of MDCKII-hMDR1 Cells  

E-print Network

, Pennsylvania; z Preclinical Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, Pennsylvania 19104; y Preclinical Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, King of Prussia, North Carolina; and § Preclinical Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Welwyn, England

Mittal, Aditya

11

76 FR 6456 - Intent To Grant an Exclusive License for a U.S. Government-Owned Invention  

Federal Register 2010, 2011, 2012, 2013, 2014

...873, issued July 3, 2001, entitled ``Inactivated Dengue Virus Vaccine,'' for the field of use involving any prophylactic and/or therapeutic purified inactivated vaccine against Dengue virus for human use. The intended licensee is GlaxoSmithKline...

2011-02-04

12

Quantifying the Impact of Prostate Volumes, Number of Biopsy Cores and 5 -Reductase Inhibitor Therapy on the  

E-print Network

and Department of Urology (MS, CGR), University of Texas Southwest Medical Center at Dallas and Dallas Urology at Charlotte (ZX), Charlotte and Urology Clinical Development and Medical Affairs Group, GlaxoSmithKline (RR

Serfling, Robert

13

1 | P a g e Accelerating Medicines Partnership  

E-print Network

and several non-profit organizations to transform the current model for developing new diagnostics-Myers Squibb · GlaxoSmithKline · Johnson & Johnson · Lilly · Merck · Pfizer · Sanofi · Takeda Non-Profit

Baker, Chris I.

14

Pharma giants swap research programs.  

PubMed

Pharmaceutical giants Novartis and GlaxoSmithKline (GSK) agreed in late April to swap some assets, with Novartis handing off its vaccine business to GSK and getting most of the British company's cancer portfolio in return. PMID:25002632

2014-07-01

15

76 FR 1181 - Oncologic Drugs Advisory Committee; Notice of Meeting  

Federal Register 2010, 2011, 2012, 2013, 2014

...irinotecan alone is ineffective or less effective; (2) supplemental BLA (sBLA) 125011/24, trade name BEXXAR (tositumomab and Iodine I 131 tositumomab), application submitted by SmithKline Beecham Corp. doing business as (d/b/a) GlaxoSmithKline,...

2011-01-07

16

77 FR 32125 - Oncologic Drugs Advisory Committee; Notice of Meeting  

Federal Register 2010, 2011, 2012, 2013, 2014

...DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration...default.htm; under the heading ``Resources for You,'' click on ``Public Meetings...submitted by SmithKline Beecham (Cork) Ltd, Ireland d/b/a GlaxoSmithKline. The...

2012-05-31

17

Eddie Smith Dean E. Smith  

E-print Network

Daniels Hill Ackland McCaskill Paul Green Eddie Smith Alumni Center Carmichael Auditorium Center Student Dean E. Smith Student Hall Kenan Field House Bookstore Affairs Stadium Kenan Hill Williams House Forest

Whitton, Mary C.

18

Stephen Jay Kline on systems, or physics, complex systems, and the gap between.  

SciTech Connect

At the end of his life, Stephen Jay Kline, longtime professor of mechanical engineering at Stanford University, completed a book on how to address complex systems. The title of the book is 'Conceptual Foundations of Multi-Disciplinary Thinking' (1995), but the topic of the book is systems. Kline first establishes certain limits that are characteristic of our conscious minds. Kline then establishes a complexity measure for systems and uses that complexity measure to develop a hierarchy of systems. Kline then argues that our minds, due to their characteristic limitations, are unable to model the complex systems in that hierarchy. Computers are of no help to us here. Our attempts at modeling these complex systems are based on the way we successfully model some simple systems, in particular, 'inert, naturally-occurring' objects and processes, such as what is the focus of physics. But complex systems overwhelm such attempts. As a result, the best we can do in working with these complex systems is to use a heuristic, what Kline calls the 'Guideline for Complex Systems.' Kline documents the problems that have developed due to 'oversimple' system models and from the inappropriate application of a system model from one domain to another. One prominent such problem is the Procrustean attempt to make the disciplines that deal with complex systems be 'physics-like.' Physics deals with simple systems, not complex ones, using Kline's complexity measure. The models that physics has developed are inappropriate for complex systems. Kline documents a number of the wasteful and dangerous fallacies of this type.

Campbell, Philip LaRoche

2011-06-01

19

ERP Modulation during Observation of Abstract Paintings by Franz Kline  

PubMed Central

The aim of this study was to test the involvement of sensorimotor cortical circuits during the beholding of the static consequences of hand gestures devoid of any meaning.In order to verify this hypothesis we performed an EEG experiment presenting to participants images of abstract works of art with marked traces of brushstrokes. The EEG data were analyzed by using Event Related Potentials (ERPs). We aimed to demonstrate a direct involvement of sensorimotor cortical circuits during the beholding of these selected works of abstract art. The stimuli consisted of three different abstract black and white paintings by Franz Kline. Results verified our experimental hypothesis showing the activation of premotor and motor cortical areas during stimuli observation. In addition, abstract works of art observation elicited the activation of reward-related orbitofrontal areas, and cognitive categorization-related prefrontal areas. The cortical sensorimotor activation is a fundamental neurophysiological demonstration of the direct involvement of the cortical motor system in perception of static meaningless images belonging to abstract art. These results support the role of embodied simulation of artist’s gestures in the perception of works of art. PMID:24130693

Sbriscia-Fioretti, Beatrice; Berchio, Cristina; Freedberg, David; Gallese, Vittorio; Umiltà, Maria Alessandra

2013-01-01

20

For personal use. Only reproduce with permission from Elsevier Ltd Perspectives  

E-print Network

claims concerning off-label uses of Neurontin. Bristol-Myers Squibb promises to pay $300 million to dis for allegedly overcharging patients and insurers for its anti-inflammatory drug, Relafen. Bayer settles billion jury verdict against Wyeth over its diet drug, Pondimin. GlaxoSmithKline (once more) agrees to pay

Colquhoun, David

21

A novel enzymatic technique for limiting drug mobility in a hydrogel matrix  

E-print Network

, GA 30332, USA c Department of Chemical and Biomolecular Engineering, North Carolina State University , Jung O. Parkb , Mohan Srinivasaraob , Saad A. Khanc,T a GlaxoSmithKline, Research Triangle Park, NC 27709, USA b School of Polymer, Textile & Fiber Engineering, Georgia Institute of Technology, Atlanta

Srinivasarao, Mohan

22

77 FR 63839 - Vaccines and Related Biological Products Advisory Committee; Notice of Meeting  

Federal Register 2010, 2011, 2012, 2013, 2014

...committee will meet in open session to discuss and make recommendations on the safety and immunogenicity of an Influenza A (H5N1) Virus Monovalent Vaccine manufactured by GlaxoSmithKline. On November 15, 2012, the committee will meet in open...

2012-10-17

23

ADVANCED PHOTON SOURCE Argonne is a U.S. Department of Energy laboratory managed by UChicago Argonne, LLC  

E-print Network

is marketed as VotrientTM in the U.S. and Europe by its developer, GlaxoSmithKline, for the treatment injections and is associated with significant risks. Research at the APS is adding to our understanding of the structure of hormone-receptor interaction, which may lead to strategies for the development of more

Kemner, Ken

24

Contacts: Olivia Goodman/Jennifer Robinson For immediate release: July 30, 2014 gabbegroup/212-220-4444  

E-print Network

solutions to combat acquaintance/date rape. Two novel product prototypes, targeted to the college population patents on both prototypes on the students' behalf. Of the roughly 12 million women enrolled in American at GlaxoSmithKline. 1 U.S. Department of Justice, "The Sexual Victimization of College Women," 2000. 2 U

McGaughey, Alan

25

75 FR 17929 - Vaccines and Related Biological Products Advisory Committee; Notice of Meeting  

Federal Register 2010, 2011, 2012, 2013, 2014

...the morning, the committee will review and discuss available data regarding the unexpected finding of DNA originating from porcine circovirus type 1 (PCV 1) in Rotarix, a U.S. licensed vaccine manufactured by GlaxoSmithKline and indicated for the...

2010-04-08

26

Chemical Engineering Andrew Zydney  

E-print Network

Chemistry Medicine Consumer Products SemiconductorsPharmaceuticals Biotechnology Chemical Engineering Fuels;ChE Employment (2003 at PSU) Merck Dow ExxonMob Air Products Amgen PPG Sunoco Kraft Foods NRC Procter and Gamble J&J Shell DuPont Aramco Conoco M&M Mars Grad School Anheuser Busch GlaxoSmith Kline Mixing

Maranas, Costas

27

Printer-friendly format E-mail this story  

E-print Network

Scalias, not Souters on court Bush proposal builds deficit, CBO reports Bush pushes Social Security heights FDA seizes depression, diabetes drugs at GlaxoSmithKline Failed doctor- assisted suicide raises The research also suggests the movement of feet is key to energy-efficient walking. "You can't know how

Ruina, Andy L.

28

Behavioral/Systems/Cognitive Cognitive Effort Drives Workspace Configuration of Human  

E-print Network

, Cambridge CB2 0SZ, United Kingdom, 2Cognition and Brain Sciences Unit, Medical Research Council, Cambridge CB2 7EF, United Kingdom, 3Clinical Unit Cambridge, GlaxoSmithKline, Addenbrooke's Centre for Clinical Investigations, Cambridge CB2 0QQ, United Kingdom Effortful cognitive performance is theoretically expected

Henson, Rik

29

BAYESIAN STATISTICS 9, J. M. Bernardo, M. J. Bayarri, J. O. Berger, A. P. Dawid,  

E-print Network

of Statistics, Shawn Simpson is a PhD student, and Ivan Zorych is a Research Scientist, all at Columbia University. Patrick Ryan is a Research Scientist at GlaxoSmithKline. #12;2 D. Madigan et al. ongoing process shrinkage approach due to DuMouchel that has been widely adopted in this context. More recent work has

Madigan, David

30

Disconnected Youth in the Research Triangle Region: An Ominous Problem Hidden in Plain Sight  

ERIC Educational Resources Information Center

In September 2006, the North Carolina GlaxoSmithKline Foundation commissioned MDC, Inc. of Chapel Hill to analyze the problem of "disconnected youth" in the Research Triangle region, determine the current state of the region's responses to the challenge, and recommend steps to deepen and accelerate action on the issue. The research process was…

Dodson, David; Guillory, Ferrel; Lipsitz, Joan; Raper, Noah; Rausch, Christina

2008-01-01

31

Tadalafil and vardenafil  

Microsoft Academic Search

In 2003, two inhibitors of phosphodiesterase 5 (PDE5) — tadalafil (Cialis; Lilly ICOS) and vardenafil hydrochloride (Levitra; Bayer\\/ GlaxoSmithKline) — were approved by the US FDA for the treatment of erectile dysfunction. Can they challenge the dominance of the first PDE5 inhibitor, sildenafil citrate (Viagra; Pfizer), which rapidly became a blockbuster following its market entry in the late 1990s?

Peter Kirkpatrick; Katherine Neumeyer

2004-01-01

32

Consortium for Robotics and Unmanned Systems Education and Research Captain Jeff Kline, USN (ret)  

E-print Network

Aerial Vehicles (UAV) § LT Matthew Pawlenko § Self-propelled semi-submersibles [electronic resourceConsortium for Robotics and Unmanned Systems Education and Research Captain Jeff Kline, USN (ret) Director, CRUSER http://www.nps.edu/Research/CRUSER #12;Consortium for Robotics and Unmanned Systems

33

Evaluating IPv6 Adoption in the Internet Lorenzo Colitti, Steinar H. Gunderson, Erik Kline, Tiziana Refice  

E-print Network

Evaluating IPv6 Adoption in the Internet Lorenzo Colitti, Steinar H. Gunderson, Erik Kline, Tiziana exhaustion, large net- works are deploying IPv6 or preparing for deployment. However, there is little data available about the quantity and quality of IPv6 connectivity. We describe a methodology to measure IPv6

Tomkins, Andrew

34

Mathematical Robert Smith?  

E-print Network

Mathematical Modelling of Zombies Robert Smith? University of Ottawa Press #12;Robert Smith by Robert Smith? Includes bibliographical references. Issued in print and electronic formats. ISBN 978. I. Smith?, Robert J. (Robert Joseph), 1972­, editor GR581.M38 2014 398.2101'51 C2014-906565-5 C2014

Maini, Philip K.

35

Variability of Solar UV Irradiance Related to Bright Magnetic Features Observed in Call K-Line: Relationship between Lyman alpha and K-line Report for UARS funding agency  

NASA Technical Reports Server (NTRS)

In this report we comment on the relationship between the Lyman alpha and Calcium K-line emission from the Sun. We firstly examine resolved Lyman alpha images (from TRACE) and resolved K-line images. We find that the Lyman alpha emission is consistent with a linear dependence on the K-line emission. As this is in conflict with the analysis of Johannesson et al.(1995, 1998) we proceed by comparing the disk integrated Lyman alpha flux as a function of ratio between the disk integrated Mg II core and wing fluxes (Johannesson et al (1998) having previously found a linear dependence between this index and the BBSO K-line index). We find that a reasonably good fit can be obtained, however note the discrepancies which lead Johannesson et al to consider the square root relationship. We suggest an alternative interpretation of the discrepancy.

Zirin, Harold; Cameron, Robert

1999-01-01

36

A simplified Katsevich algorithm motivated by the distribution properties of k-lines  

PubMed Central

The Katsevich algorithm is a breakthrough in the theoretically exact algorithms for helical cone beam CT. For future application in medical and industrial CT, determining how to implement it efficiently and accurately is the main task. We analyzed the slope law and intersection law of the k-lines, finding that the k-lines are not intersecting if the half maximal fan angle (HMFA) is less than 21° (numerical solution, so it is approximate) and that the helical pitch and HMFA determine the depth of parallelism of k-lines. Using an appropriate pitch and a HWFA that is less than 21°, one can use a simplified Katsevich algorithm, whose filtration process can be done on the rows of the detector panel so that the pre-weighting, pre-rebinning, post-rebinning and post-weighting steps are all canceled. Simulation experiments show that the simplified algorithm can obtain highly precise images at a faster speed. Our results are intended to be valuable to those who are working on efficient implementations of the Katsevich-type algorithms.

Qiao, Zhiwei; Redler, Gage; Halpern, Howard

2015-01-01

37

Carrington Maps of Ca II K-line Emission for the Years 1915-1985  

NASA Astrophysics Data System (ADS)

We have used Mount Wilson Observatory calcium K-line images, digitized and flat fielded by the solar group at UCLA, to construct Carrington maps of Ca II 3934 Å intensity for the years 1915-1985. These maps have a spatial resolution comparable to the resolution of Carrington maps of the magnetic field observed at Kitt Peak and a spectral resolution comparable to the width of the K232 emission. Consequently, they provide a way of tracking the spatial distribution of magnetic flux from the present back to the year 1915. In this paper, we compare some of the recent K-line maps with corresponding maps of magnetic field, and show examples of K-line maps during earlier sunspot cycles when high-quality magnetograms were not available. Then, we use butterfly diagrams and super-synoptic displays to summarize the long-term evolution of the patterns of calcium intensity. Although each cycle has characteristics that are similar to the others, cycle 19 is remarkable for its broad latitudinal distribution of active regions, for its giant poleward surges of flux, and for the emergence of a north-south asymmetry that lasted 10 years.

Sheeley, N. R., Jr.; Cooper, T. J.; Anderson, J. R. L.

2011-03-01

38

Vanderbilt University 200 Smith Court  

E-print Network

John Smith Vanderbilt University 200 Smith Court Smithville, TN 37000 April 12, 20xx Ms. Janice-5000 or john.smithy.smith@vanderbilt.edu, and I thank you for your consideration. Sincerely, (Signature Here) John Smith #12;

Bordenstein, Seth

39

Joseph Smith the Prophet  

NSDL National Science Digital Library

Just a quick look at the Prophet Joseph Smith\\'s life and all that he accomplished. As you go to the site below think of the following questions: What do you think was the greatest contribution the Prophet Joseph Smith made? What can you do today to show him your appreciation and to keep the work moving forward? Key Events in the Life of Joseph Smith While looking through the church sites ask yourself the following question: Which ...

Mr. Shane Carter

2006-10-23

40

David Smith Academic background  

E-print Network

David Smith Academic background Ph.D. in Mathematics (Algebra), Université de Sherbrooke, Canada project program (I. Assem, F. Bergeron, C. Reutenauer, D. Smith) $132,000 ($44,000 per year for 3 years. Schiffler and D. Smith, Friezes, strings and cluster variables, to appear in Glasgow Mathematcal Journal. 2

41

Joshua Smith Spring 2006  

E-print Network

Stormwater Utilities in Georgia Joshua Smith Spring 2006 #12;The UGA Land Use Clinic provides in Georgia Author: Joshua Smith Editor: Jamie Baker Roskie University of Georgia Land Use Clinic Spring 2006....................................................................................................10 #12;#12;1Stormwater Utilities in Georgia Stormwater Utilities in Georgia Joshua Smith Spring 2006

Rosemond, Amy Daum

42

Adam Smith and Isaac Newton  

Microsoft Academic Search

The commonly held view that Adam Smith patterned economics after Issac Newton's method is examined and dismissed. Both Smith and Newton's methods are explored and compared. Smith's method is shown to have differed significantly from Newton's--in spite of Smith's pronouncements to the contrary--for reasons best explained by considering the Scottish tradition. Finally, the significance of Smith's methodology for modern economics

Deborah A. Redman

1993-01-01

43

The Adam Smith Page  

NSDL National Science Digital Library

Edward J. Harpham, Associate Professor of Government and Political Economy at the University of Texas at Dallas, developed this new site to promote the study of the moral, political, and economic ideas of Adam Smith. Anyone with an interest in Smith's ideas will find numerous resources of interest. Perhaps the most useful are Harpham's updated lists of new and forthcoming scholarly articles and books on Smith. Students will also benefit from the comprehensive bibliography of secondary works, brief commentaries on Smith's works, and the collection of related links.

Harpham, Edward J.

1998-01-01

44

Low-frequency and rare exome chip variants associate with fasting ?glucose and type 2 diabetes susceptibility  

E-print Network

of genotyping across the exome chip and GWAS platforms were checked in ARIC and FHS and was 499%. After SNV-level and sample-level quality control, 197,481 variants were available for analyses. The minor allele frequency spectrums of the exome chip SNVs... (FHS, N¼ 666) and Rotterdam Study (RS, N¼ 702)) and three additional studies, Eras- mus Rucphen Family Study (ERF, N¼ 1,196), the Exome Sequencing Project (ESP, N¼ 1,338) and the GlaxoSmithKline discovery sequence project3 (GSK, N¼ 6,666). The Glaxo...

Wessel, Jennifer; Chu, Audrey Y; Willems, Sara M; Wang, Shuai; Yaghootkar, Hanieh; Brody, Jennifer A; Dauriz, Marco; Hivert, Marie-France; Raghavan, Sridharan; Lipovich, Leonard; Hidalgo, Bertha; Fox, Keolu; Huffman, Jennifer E; An, Ping; Lu, Yingchang; Rasmussen-Torvik, Laura J; Grarup, Niels; Ehm, Margaret G; Li, Li; Baldridge, Abigail S; Stancakova, Alena; Abrol, Ravinder; Besse, Celine; Boland, Anne; Bork-Jensen, Jette; Fornage, Myriam; Freitag, Daniel F; Garcia, Melissa E; Guo, Xiuqing; Hara, Kazuo; Isaacs, Aaron; Jakobsdottir, Johanna; Lange, Leslie A; Layton, Jill C; Li, Man; Hua Zhao, Jing; Meidtner, Karina; Morrison, Alanna C; Nalls, Mike A; Peters, Marjolein J; Sabater-Lleal, Maria; Schurmann, Claudia; Silveira, Angela; Smith, Albert V; Southam, Lorraine; Stoiber, Marcus H; Strawbridge, Rona J; Taylor, Kent D; Varga, Tibor V; Allin, Kristine H; Amin, Najaf; Aponte, Jennifer L; Aung, Tin; Barbieri, Caterina; Bihlmeyer, Nathan A; Boehnke, Michael; Bombieri, Cristina; Bowden, Donald W; Burns, Sean M; Chen, Yuning; Chen, Yii-DerI; Cheng, Ching-Yu; Correa, Adolfo; Czajkowski, Jacek; Dehghan, Abbas; Ehret, Georg B; Eiriksdottir, Gudny; Escher, Stefan A; Farmaki, Aliki-Eleni; Franberg, Mattias; Gambaro, Giovanni; Giulianini, Franco; Goddard, William A; Goel, Anuj; Gottesman, Omri; Grove, Megan L; Gustafsson, Stefan; Hai, Yang; Hallmans, Goran; Heo, Jiyoung; Hoffmann, Per; Ikram, Mohammad K; Jensen, Richard A; Jorgensen, Marit E; Jorgensen, Torben; Karaleftheri, Maria; Khor, Chiea C; Kirkpatrick, Andrea; Kraja, Aldi T; Kuusisto, Johanna; Lange, Ethan M; Lee, I T; Lee, Wen-Jane; Leong, Aaron; Liao, Jiemin; Liu, Chunyu; Liu, Yongmei; Lindgren, Cecilia M; Linneberg, Allan; Malerba, Giovanni; Mamakou, Vasiliki; Marouli, Eirini; Maruthur, Nisa M; Matchan, Angela; McKean-Cowdin, Roberta; McLeod, Olga; Metcalf, Ginger A; Mohlke, Karen L; Muzny, Donna M; Ntalla, Ioanna; Palmer, Nicholette D; Pasko, Dorota; Peter, Andreas; Rayner, Nigel W; Renstrom, Frida; Rice, Ken; Sala, Cinzia F; Sennblad, Bengt; Serafetinidis, Ioannis; Smith, Jennifer A; Soranzo, Nicole; Speliotes, Elizabeth K; Stahl, Eli A; Stirrups, Kathleen; Tentolouris, Nikos; Thanopoulou, Anastasia; Torres, Mina; Traglia, Michela; Tsafantakis, Emmanouil; Javad, Sundas; Yanek, Lisa R; Zengini, Eleni; Becker, Diane M; Bis, Joshua C; Brown, James B; Adrienne Cupples, L; Hansen, Torben; Ingelsson, Erik; Karter, Andrew J; Lorenzo, Carlos; Mathias, Rasika A; Norris, Jill M; Peloso, Gina M; Sheu, Wayne H.-H.; Toniolo, Daniela; Vaidya, Dhananjay; Varma, Rohit; Wagenknecht, Lynne E; Boeing, Heiner; Bottinger, Erwin P; Dedoussis, George; Deloukas, Panos; Ferrannini, Ele; Franco, Oscar H; Franks, Paul W; Gibbs, Richard A; Gudnason, Vilmundur; Hamsten, Anders; Harris, Tamara B; Hattersley, Andrew T; Hayward, Caroline; Hofman, Albert; Jansson, Jan-Hakan; Langenberg, Claudia; Launer, Lenore J; Levy, Daniel; Oostra, Ben A; O'Donnell, Christopher J; O'Rahilly, Stephen; Padmanabhan, Sandosh; Pankow, James S; Polasek, Ozren; Province, Michael A; Rich, Stephen S; Ridker, Paul M; Rudan, Igor; Schulze, Matthias B; Smith, Blair H; Uitterlinden, Andre G; Walker, Mark; Watkins, Hugh; Wong, Tien Y; Zeggini, Eleftheria; The EPIC-InterAct Consortium; Laakso, Markku; Borecki, Ingrid B; Chasman, Daniel I; Pedersen, Oluf; Psaty, Bruce M; Shyong Tai, E; van Duijn, Cornelia M; Wareham, Nicholas J; Waterworth, Dawn M; Boerwinkle, Eric; Linda Kao, W H; Florez, Jose C; Loos, Ruth J.F.; Wilson, James G; Frayling, Timothy M; Siscovick, David S; Dupuis, Josee; Rotter, Jerome I; Meigs, James B; Scott, Robert A; Goodarzi, Mark O

2015-01-29

45

Dean of Libraries Steven Smith  

E-print Network

Dean of Libraries Steven Smith Development Director Erin Horeni-Ogle Associate Dean for Collections Dean Rita Smith Assessment Business Services Community Learning Services & Diversity Programs Hodges Library Council (Advisory) #12;Dean Steven Smith Head, Special Collections Jennifer Beals Special

Wang, Xiaorui "Ray"

46

JAMES E. SMITH December 2013  

E-print Network

1 JAMES E. SMITH December 2013 ADDRESS Fuqua School of Business. #12;2 PUBLICATIONS David B. Brown and James E. Smith. 2012. "Optimal Sequential Exploration: Bandits, Clairvoyants, and Wildcats." Operations Research 61 (3), 644665. James E. Smith and Canan

Reif, John H.

47

Smith Tackles Oakland Unified  

ERIC Educational Resources Information Center

As a 20-something, Anthony "Tony" Smith had fulfilled one dream: playing professional football for the Green Bay Packers and the San Francisco 49ers. Next up, he thought, was law school, but a former mentor reminded him that he is a teacher. Smith never became a classroom teacher, but his background in sports--where he learned the power of…

Mellon, Ericka

2011-01-01

48

Drugs for bad bugs: confronting the challenges of antibacterial discovery  

Microsoft Academic Search

The sequencing of the first complete bacterial genome in 1995 heralded a new era of hope for antibacterial drug discoverers, who now had the tools to search entire genomes for new antibacterial targets. Several companies, including GlaxoSmithKline, moved back into the antibacterials area and embraced a genomics-derived, target-based approach to screen for new classes of drugs with novel modes of

David J. Payne; Michael N. Gwynn; David J. Holmes; David L. Pompliano

2006-01-01

49

Solar Cycle Variability and Surface Differential Rotation from Ca II K-Line Time Series Data  

E-print Network

Analysis of over 36 years of time series data from the NSO/AFRL/Sac Peak K-line monitoring program elucidates five components of the variation of the seven measured chromospheric parameters: (a) the solar cycle (period ~ 11 years), (b) quasi-periodic variations (periods ~100 days), (c) a broad band stochastic process (wide range of periods), (d) rotational modulation, and (e) random observational errors, independent of (a)-(d). Correlation and power spectrum analyses elucidate periodic and aperiodic variation of these parameters. Time-frequency analysis illuminates periodic and quasi periodic signals, details of frequency modulation due to differential rotation, and in particular elucidates the rather complex harmonic structure (a) and (b) at time scales in the range ~0.1 - 10 years. These results using only full-disk data suggest that similar analyses will be useful at detecting and characterizing differential rotation in stars from stellar light-curves such as thosebeing produced by NASA's Kepler observator...

Scargle, Jeffrey; Worden, Pete

2013-01-01

50

Solar Cycle Fine Structure and Surface Rotation from Ca II K-Line Time Series Data  

NASA Technical Reports Server (NTRS)

Analysis of three and a half decades of data from the NSO/AFRL/Sac Peak K-line monitoring program yields evidence for four components to the variation: (a) the solar cycle, with considerable fine structure and a quasi-periodicity of 122.4 days; (b) a stochastic process, faster than (a) and largely independent of it, (c) a quasi-periodic signal due to rotational modulation, and of course (d) observational errors (shown to be quite small). Correlation and power spectrum analyses elucidate periodic and aperiodic variation of these chromospheric parameters. Time-frequency analysis is especially useful for extracting information about differential rotation, and in particular elucidates the connection between its behavior and fine structure of the solar cycle on approximately one-year time scales. These results further suggest that similar analyses will be useful at detecting and characterizing differential rotation in stars from stellar light-curves such as those being produced at NASA's Kepler observatory.

Scargle, Jeff; Keil, Steve; Worden, Pete

2011-01-01

51

This article was downloaded by:[Smith, Bradley] [Smith, Bradley  

E-print Network

This article was downloaded by:[Smith, Bradley] [Smith, Bradley] On: 9 April 2007 Access Details. © Taylor and Francis 2007 #12;DownloadedBy:[Smith,Bradley]At:21:299April2007 Recent Advances in Synthetic Membrane Transporters BETH A. MCNALLY, W. MATTHEW LEEVY and BRADLEY D. SMITH* Department of Chemistry

Smith, Bradley D.

52

C. E. Smith, Page 1 of 2 Cartney E. Smith  

E-print Network

C. E. Smith, Page 1 of 2 Cartney E. Smith cesmith5@illinois.edu Education University of Illinois, C. E. Smith, K. Kim, H. Kong, "Tailoring Polymersome Bilayer Permeability Improves Enhanced. Vega L., M. K. Lee, J. H. Jeong, C. E. Smith, K. Y. Lee, H. J. Chung, D. E. Leckband, H. Kong

Bashir, Rashid

53

Aaron Lee Smith The Dissertation Committee for Aaron Lee Smith  

E-print Network

Copyright by Aaron Lee Smith 2009 #12;The Dissertation Committee for Aaron Lee Smith certifies Compilation by Aaron Lee Smith, B.A., M.S. Dissertation Presented to the Faculty of the Graduate School thank my family for their encouragement. Aaron Lee Smith The University of Texas at Austin December 2009

John, Lizy Kurian

54

Smith et al Supporting Information  

E-print Network

Smith et al 1 Supporting Information for Smith et al. 2006, PLoS Computational Biology 2:e161-hyperpallium apicale; HF-hippocampal formation, and M-mesopallium. #12;Smith et al 2 FigureS2,nolinkswerefoundbetweenelectrodesindifferentbirds,andnolinkswerefoundintothesoundstimulusvariable. CombinedAnalysisofAllBirds'ElectrodesPlusSound #12;Smith et al 3 Analysis of Data from Subsections

Jarvis, Erich D.

55

Neurosciences Eddie Smith  

E-print Network

Ambulatory Care Thurston Bowles Neurosciences MBRB Carolina Inn Paul Green Graham Davis Lib Eddie Smith Field Pettigrew Hyde Graham Old Well Person New West Ackland Public Safety Koury Horton Craige N House Lib Manning

Lieb, Jason

56

The Relevance of Adam Smith  

NSDL National Science Digital Library

The Federal Reserve Bank of Richmond explores the relevance of eighteenth-century economist Adam Smith in today's world. Quoting heavily from Smith's famous work The Wealth of Nations, this article summarizes many of Smith's main themes and ideas, and attempts to prove that Smith's "ideas have become so thoroughly absorbed into our intellectual heritage that they are no longer identifiable as having originated with Adam Smith."

57

Study of K-line radiation of thick titanium produced in collisions of keV electrons.  

PubMed

The characteristic K-line yields Y(E?) of a pure thick titanium (Z=22) element target are measured for 8-18 keV electron impact and compared with the simulation calculations using PENELOPE code. A fair agreement between experiment and simulation results is found within the existing experimental uncertainty of measurements. The ratio F of indirectly produced characteristic Ti K X-ray yield to its total (directly+indirectly) yield is determined by employing an approximate analytical formulation of Hanson and Cowan (Hanson, H.P., Cowan, D.J., 1961. Phys. Rev. 124, 22-26). It is found that F changes strongly with impact energy E? for normal angle of incidence in contrast to a mild change predicted by the simulation calculations. Furthermore, experimental and simulation results for peak to effective continuum ratio R of Ti K-line are compared and discussed for the energy range of impact of the present investigation. PMID:21723738

Yadav, Namita; Bhatt, Pragya; Singh, Raj; Llovet, X; Shanker, R

2011-10-01

58

Director HR Andrew J Smith  

E-print Network

Director HR Andrew J Smith Associate Director HR Shared Services Miya Chiba Associate Director Payroll Officer John Smith Systems & Project Analyst Blair Jordan HR Reporting Analyst Yana Zhang Manager

Liley, David

59

Evaluation of effects of T and N type calcium channel blockers on the electroencephalogram recordings in Wistar Albino Glaxo/Rij rats, an absence epilepsy model  

PubMed Central

Objectives: It is suggested that excessive calcium entry into neurons is the main triggering event in the initiation of epileptic discharges. We aimed to investigate the role of T and N type calcium channels in absence epilepsy experimental model. Materials and Methods: Wistar Albino Glaxo/Rij (WAG/Rij) rats (12–16 weeks old) were randomly allocated into four groups; sham, mibefradil (T type calcium channel blocker), w-Conotoxin MVIIA (N type calcium channel blocker), and mibefradil + w-Conotoxin MVIIA. Beta, alpha, theta, and delta wave ratios of EEG recordings and frequency and duration of spike wave discharges (SWDs) were analyzed and compared between groups. Results: Beta and delta recording ratios in 1 ?M/5 ?l mibefradil group was significantly different from basal and other dose-injected groups. Beta, alpha, and theta recordings in 0.2 ?M/5 ?l w-Conotoxin MVIIA group was significantly different from basal and other dose-injected groups. In w-Conotoxin MVIIA after mibefradil group, beta, alpha, and theta recording ratios were significantly different from basal and mibefradil group. Mibefradil and w-Conotoxin MVIIA significantly decreased the frequency and duration of SWDs. The decrease of frequency and duration of SWDs in mibefradil group was significantly different from w-Conotoxin MVIIA group. The frequency and duration of SWDs significantly decreased in w-Conotoxin MVIIA after mibefradil group compared with basal, mibefradil, and w-Conotoxin MVIIA groups. Conclusions: We concluded that both T and L type calcium channels play activator roles in SWDs and have positive effects on frequency and duration of these discharges. These results are related with their central effects more than peripheral effects.

Durmus, Nedim; Gültürk, Sefa; Kaya, Tijen; Demir, Tuncer; Parlak, Mesut; Altun, Ahmet

2015-01-01

60

Effect of vasopressin on the expression of genes for key enzymes of hyaluronan turnover in Wistar Albino Glaxo and Brattleboro rat kidneys.  

PubMed

Hyaluronan (HA), the major glycosaminoglycan of the interstitial matrix, is heterogeneously distributed within the kidney. Using real-time RT-PCR, we tested the assumption that renal HA may be involved in the long-term effect of vasopressin on water reabsorption. The expression of the genes encoding hyaluronan synthase-2 (Has2), hyaluronidase-1 and hyaluronidase-2 (Hyal1 and Hyal2) was studied in the kidneys of Wistar Albino Glaxo (WAG) and homozygous vasopressin-deficient Brattleboro rats treated with the V2 receptor-selective vasopressin analogue dDAVP (100 ?g (kg body wt)(-1), i.p., twice a day for 2 days). The Has2 mRNA content was the highest in the kidney papilla of the hydrated WAG and control Brattleboro rats, devoid of vasopressin. In WAG rats, dDAVP induced a considerable decrease in Has2 mRNA content in the papilla, with less pronounced changes in the cortex. The changes elicited by dDAVP in Brattleboro rats tended to be the same as in WAG rats, but weaker. In contrast to Has2, dDAVP treatment caused a significant increase in the Hyal1 and Hyal2 mRNA content in the renal papilla of WAG and Brattleboro rats. In rats of both strains, there was a good fit between Hyal1 and Hyal2 transcriptional levels and changes in hyaluronidase activity in the renal tissue. It is suggested that vasopressin is able to inhibit the synthesis of HA and concomitantly promote its degradation in the interstitium of the renal papilla, thereby facilitating water flow between elements of the renal countercurrent system. The implications for this effect are discussed in the context of the data in the literature. PMID:23955305

Ivanova, Lyudmila N; Babina, Alina V; Baturina, Galina S; Katkova, Lyubov E

2013-11-01

61

Deborah K. Smith Senior Scientist  

E-print Network

Deborah K. Smith Senior Scientist Woods Hole Oceanographic Institution Publications: Jordan, T. H., H. W. Menard, and D.K. Smith, Density and size distribution of seamounts in the eastern Pacific inferred from wide-beam sounding data, J. Geophys. Res., 88, 10508-10518, 1983. Kim, I. I., D. K. Smith, H

Smith, Deborah K.

62

Copyright 2005 Veronica Susanne Smith  

E-print Network

Copyright 2005 Veronica Susanne Smith #12;Evaluating Spatial Normalization Methods for the Human Brain Veronica Susanne Smith A thesis submitted in partial fulfillment of the requirements for the Human Brain Veronica Susanne Smith Chair of the Supervisory Committee: Professor Linda S. Shapiro

Washington at Seattle, University of

63

Presented by Jeremy C. Smith  

E-print Network

Presented by Biosystems Jeremy C. Smith Center for Molecular Biophysics Biosciences Division #12;2 Managed by UT-Battelle for the U.S. Department of Energy Smith_Biosystems_SC10 Simulation model and cellulose Length-scale1 nm 1 m * L. Petridis and J. C. Smith (2009), "A molecular mechanics force field

64

Victoria Anne Smith Curriculum Vitae  

E-print Network

Victoria Anne Smith Curriculum Vitae School of Biology anne.smith@st-andrews.ac.uk University of St-I £83,318 (of £4.5M) Oct 2006 ­ Sep 2010 #12;V. Anne Smith, Curriculum Vitae, Page 2 Past Research

Smith, V Anne

65

Kevin Smith Sutherland House 234  

E-print Network

Kevin Smith Sutherland House 234 PMB 3342 Nashville, TN 37235 January 27, 2010 Mr. Scott at Kevin.m.smith@vanderbilt.edu or by phone at (543)3843909. Thank you for your consideration. Sincerely, Kevin Smith The cover letter needs to be in business letter format...this includes

Bordenstein, Seth

66

Curriculum Vitae Douglas E. Smith  

E-print Network

6/2014 Curriculum Vitae Douglas E. Smith ADDRESS Department of Physics, University of California Foundation Fellowship, 2003 · Beckman Young Investigator Award, 2003 #12;Doug Smith CV 7/2014 2 · Searle.E. Smith Physical Review Letters 112, 248101 (2014) - Highlighted by a perspective in Science: Yann R

Smith, Douglas E.

67

Ashley Wilder Smith's biography  

Cancer.gov

Ashley Wilder Smith, PhD, MPH is a Behavioral Scientist and Program Director in the Outcomes Research Branch of the Applied Research Program. Her program of research focuses on developing, advancing and promoting investigations related to improving current understanding of patient reported outcomes and quality care for cancer patients, survivors and families. In particular, Dr.

68

SOLAR CYCLE VARIABILITY AND SURFACE DIFFERENTIAL ROTATION FROM Ca II K-LINE TIME SERIES DATA  

SciTech Connect

Analysis of over 36 yr of time series data from the NSO/AFRL/Sac Peak K-line monitoring program elucidates 5 components of the variation of the 7 measured chromospheric parameters: (a) the solar cycle (period {approx} 11 yr), (b) quasi-periodic variations (periods {approx} 100 days), (c) a broadband stochastic process (wide range of periods), (d) rotational modulation, and (e) random observational errors, independent of (a)-(d). Correlation and power spectrum analyses elucidate periodic and aperiodic variation of these parameters. Time-frequency analysis illuminates periodic and quasi-periodic signals, details of frequency modulation due to differential rotation, and in particular elucidates the rather complex harmonic structure (a) and (b) at timescales in the range {approx}0.1-10 yr. These results using only full-disk data suggest that similar analyses will be useful for detecting and characterizing differential rotation in stars from stellar light curves such as those being produced by NASA's Kepler observatory. Component (c) consists of variations over a range of timescales, in the manner of a 1/f random process with a power-law slope index that varies in a systematic way. A time-dependent Wilson-Bappu effect appears to be present in the solar cycle variations (a), but not in the more rapid variations of the stochastic process (c). Component (d) characterizes differential rotation of the active regions. Component (e) is of course not characteristic of solar variability, but the fact that the observational errors are quite small greatly facilitates the analysis of the other components. The data analyzed in this paper can be found at the National Solar Observatory Web site http://nsosp.nso.edu/cak{sub m}on/, or by file transfer protocol at ftp://ftp.nso.edu/idl/cak.parameters.

Scargle, Jeffrey D.; Worden, Simon P. [NASA Ames Research Center, Moffett Field, CA, 94035 (United States); Keil, Stephen L. [National Solar Observatory, P.O. Box 57, Sunspot, NM 88349 (United States)

2013-07-01

69

Smith–Magenis syndrome  

Microsoft Academic Search

Smith–Magenis syndrome (SMS) is a complex neurobehavioral disorder caused by haploinsufficiency of the retinoic acid-induced 1 (RAI1) gene on chromosome 17p11.2. Diagnostic strategies include molecular identification of a 17p11.2 microdeletion encompassing RAI1 or a mutation in RAI1. G-banding and fluorescent in situ hybridization (FISH) are the classical methods used to detect the SMS deletions, while multiplex ligation-dependent probe amplification (MLPA)

Sarah H Elsea; Santhosh Girirajan

2008-01-01

70

Portrait of Waldo Smith  

NASA Astrophysics Data System (ADS)

In 1944, Waldo Smith was looking for a place where he could make a difference. He had taught in universities in the United States and Turkey, and he had worked as an engineer in the field of hydrology in the United States. Somehow, a chance meeting with John Adam Fleming, AGU's long-time General Secretary, led to Waldo's becoming the first executive officer employed by the Union. That, in turn, brought him the opportunity to make a difference.

Spilhaus, Fred

2009-01-01

71

Sophia Smith Collection  

NSDL National Science Digital Library

As part of the Five College Archives Digital Access Project (mentioned in the September 25, 1998 Scout Report), Smith College has digitized some of its archival holdings relating to women's history. The Website of the Sophia Smith Collection presents still more of the Smith College holdingsof "manuscripts, photographs, periodicals and other primary sources in women's history." The site includes brief descriptions of over 300 manuscript collections, lesson plans for using primary source materials, links to additional women's history resources, and selected digital images. A permanent exhibition, Agents of Social Change, showcases some materials online. The exhibit contains pictures and digitized documents on eight 20th-century women and organizations working for women's rights. Visitors will find items such as a brochure about the National Congress of Neighborhood Women (NCNW), a grassroots feminist organization; a 1980 photo of an NCNW march on New York City Hall; Gloria Steinem photographed at the Ms. office in 1983; and fan mail to Steinem after a TV appearance.

72

Getting to know Joseph Smith  

NSDL National Science Digital Library

In these simple modules you will commit to memory 6 important dates in the life of Joseph Smith. Attempt to remember the date before clicking on the link directly under the picture. Write the dates in your journal and present the journal to Bro. Davidson for credit Joseph Smith was born in Sharon, Windsor county, Vermont in _____? Cute baby boy Birth date The first vision occurred in _____? first vision First vision date Moroni then visits the prophet in ____? Moroni Moroni visitations Joseph marries Emma ____? Emma Smith Marriage The church is officially reorganized in ____? Church restored Restoration Joseph and Hyrum martyred in ____? Martyrdom of Joseph Smith Martyrdom ...

Bro. Davidson

2010-06-09

73

Page 1 of 7 DEBORAH K. SMITH  

E-print Network

Smith - CV Page 1 of 7 DEBORAH K. SMITH Senior Scientist TEL.: (508) 289-2472 Department of Geology, and the Environment: Our Changing Oceans #12;Smith - CV Page 2 of 7 2011 NOAA OER Atlantic Basin Workshop, URI Coastal

Smith, Deborah K.

74

Genetics Home Reference: Smith-Magenis syndrome  

MedlinePLUS

... PubMed Recent literature OMIM Genetic disorder catalog Conditions > Smith-Magenis syndrome On this page: Description Genetic changes ... names Glossary definitions Reviewed December 2013 What is Smith-Magenis syndrome? Smith-Magenis syndrome is a developmental ...

75

Expanded Plain TEX Steven Smith  

E-print Network

Expanded Plain TEX Sept 2004 2.8.4 Karl Berry Steven Smith #12;This manual documents the Eplain Berry. Steven Smith wrote the documentation for the commutative diagram macros. (He also wrote the macros.) Some additions/corrections by Adam Lewenberg. Permission is granted to make and distribute

Mintmire, John W.

76

Adam Smith's Problems and Ours  

Microsoft Academic Search

The paper contrasts what modern economists, reflecting the priorities of general equilibrium theory, expect to find in the Wealth of Nations with Smith's own much broader theoretical and policy concerns. A theory of growth in which increasing returns are pervasive conflicts not only with neo-classical expectations but with the emphasis on diminishing returns to be found in Smith's classical successors.

Donald Winch

1997-01-01

77

Circuit reconstruction tools today Stephen J Smith  

E-print Network

Circuit reconstruction tools today Stephen J Smith To understand how a brain processes information, Stanford University School of Medicine, Stanford, CA 94305, United States Corresponding author: Smith

Born, Richard

78

Evaluating baseball bat performance L. V. Smith  

E-print Network

Evaluating baseball bat performance L. V. Smith School of Mechanical and Materials Engineering address: L. V. Smith, School of Mechanical and Materials Engineering, Washington State University, Pullman

Smith, Lloyd V.

79

Sophia Smith Collection: Women's History Archives at Smith College  

NSDL National Science Digital Library

The Sophia Smith Collection at Smith College was made possible under the guidance of its first director, Margaret Storrs Grierson. In 1946, it was named in honor of the founder of Smith College and it has grown to include over 650 different thematic collections. On this page, visitors can browse through their online image collections, oral histories, and exhibits. The oral histories are quite a treat, as they include 50 in-depth interviews which document the persistence and diversity of organizing for women in the United States. Additionally, this area contains interviews on population and reproductive health and conversations with student activists at Smith College. The Online Exhibits area includes nine thematic collections. One of the most interesting among them is the Girl Zines collection, which features independent magazines that address "third wave" feminism and sexuality. Finally, visitors can use the Finding Images section to look over 300 items that include political buttons, handicrafts, and cartoons.

2012-07-13

80

Curriculum Vitae -Smith, J.L. 1 JULIETTE L. SMITH  

E-print Network

.F., Hubbard, K.A., Richlen, M.L., Smith, J.L., Bates, S.S., Ehrmane, J., Légerd, C., Mafra L.L. Jr., Kulis, D and Forestry, SUNY, Kimberly L. Schulz, Gregory L. Boyer 1999-2002 M.S. Biological Sciences, University of New-Reviewed *co-first authorship 1. Tong, M., *Smith, J.L., Richlen, M.L., Steidinger, K., Kulis, D., Fux, E

Maa, Jerome P.-Y.

81

Contemporary conceptual space: reading Adam Smith  

Microsoft Academic Search

This paper encourages an examination of the conceptual space which Adam Smith’s work and legacy present and which conditions thinking about governmental and societal organization and management. The paper, situating Smith in his eighteenth-century context, distinguishes between the historical Smith and his legacy. It analyzes the invisible hand doctrine, showing that the doctrine should be understood in the context of

David John Farmer

1997-01-01

82

Ole M. Smith Assistant Administrative  

E-print Network

Ole M. Smith Assistant Administrative Vice President Physical Facilities Ray Bernier Managing Director Facilities Planning and Construction Jim Dain Managing Director Buildings, Trans. and Grounds Dan Becky Lynn Fox Executive Secretary Anne Schroeder Director Space Management Richard Nelson Director Arch

Seamons, Kent E.

83

Adrienne Smith Long, Doctoral Fellow  

Cancer.gov

Adrienne Smith graduated summa cum laude from McCormick School of Engineering at Northwestern University in 2008 with a Bachelors of Science in Biomedical Engineering and matriculated into the Feinberg School of Medicine at Northwestern in 2008.

84

Smith-Magenis syndrome.  

PubMed

Smith-Magenis syndrome (SMS) is a mental retardation syndrome with distinctive behavioral characteristics, dysmorphic features, and congenital anomalies ascribed to an interstitial deletion of chromosome 17p11.2. Severe sleep disturbances and maladaptive daytime behavior have been linked to an abnormal circadian rhythm of melatonin with a diurnal instead of nocturnal secretion of this hormone. SMS provides a demonstration of a biological basis for sleep disorder in a genetic disease. Considering that clock genes mediate the generation of circadian rhythm, haploinsufficiency for a circadian system gene, mapping to chromosome 17p11.2, may cause the inversion of the melatonin circadian rhythm in SMS. The disorder of circadian timing in SMS may also affect entrainment pathway (retinohypothalamic tract), pacemaker functions (suprachiasmatic nuclei), or synthesis and release of melatonin by the pineal gland. Elucidating pathophysiological mechanisms of behavioral phenotypes in genetic disease can provide an original therapeutic approach in SMS: blockade of endogenous melatonin production during the day combined with exogenous melatonin administration in the evening. PMID:23622179

De Leersnyder, H

2013-01-01

85

Cowboy Photographer: Erwin E. Smith  

NSDL National Science Digital Library

While many are familiar with the romantic notion of the American cowboy as crafted by Frederic Remington and Charles M. Russell, few share intimate knowledge of a lesser known artist, Erwin E. Smith. This online exhibit, created by the Amon Carter Museum in Texas, seeks to rectify that situation through this extensive archive of photographs by Smith that capture the world of the cowboy around the turn of the 20th century. Smith grew up in Texas collecting prints of paintings by artists like George Catlin and Frederic Remington. He later ended up studying art with Lorado Taft at the Art Institute of Chicago, and then at the School of the Boston Museum of Fine Arts. Smith later moved back West, and between 1905 and 1912, he took thousands of photographs on ranches throughout Texas, New Mexico, and Arizona. The photographs available online here are divided into several main sections for convenient browsing, including Cowhand clothing, Rodeo, and Ranches. Along with a biography of Smith, the site also includes a glossary of terms used by cowboys and ranchers, as well as several teaching resources for educators.

86

Disease Caused by Rotavirus Infection  

PubMed Central

Although rotavirus vaccines are available, rotaviruses remain the major cause of childhood diarrheal disease worldwide. The Rotarix (GlaxoSmithKline Biologicals Rixensart, Belgium) and RotaTeq (Merck and Co., Inc. Whitehouse Station, New Jersey, USA) vaccines are effective for reducing the morbidity and mortality of rotavirus infection. This article aims to assess the epidemiology of rotaviral gastroenteritis and the efficacy and effectiveness of licensed rotavirus vaccines. This review concludes by presenting challenges in the field that require further exploration by and perspectives from basic and translational research in the future. PMID:25553142

Lin, Che-Liang; Chen, Shou-Chien; Liu, Shyun-Yeu; Chen, Kow-Tong

2014-01-01

87

The genetics of a pharma merger.  

PubMed

The 1990s and early years of this century have seen a series of large-scale mergers and acquisitions in the Pharmaceutical and Biotech arena. These activities each required integration at multiple levels. One of the most important activities is the integration of the R&D pipelines of the participants. We outline the combined portfolio and bioinformatic strategy that was used, and detail the lessons learned for the longer term, from the GlaxoWellcome-SmithKline-Beecham merger in 2000. To date, this has been the largest merger of two equally sized Pharma R&D organisations. PMID:19121408

Sanseau, Philippe; Chabot-Fletcher, Marie; Browne, Michael J

2009-04-01

88

28th Annual JPMorgan Healthcare Conference--Human Genome Sciences and Celgene.  

PubMed

The JPMorgan Healthcare Conference, held in San Francisco, included presentations by various pharmaceutical companies summarizing their achievements in 2009 and expectations for 2010. This conference report highlights presentations from Human Genome Sciences Inc and Celgene Corp. Investigational drugs from Human Genome Sciences, including belimumab (in collaboration with GlaxoSmithKline plc), albinterferon alfa-2b (with Novartis AG), mapatumumab (with Takeda Pharmaceutical Co Ltd) and HGS-1029, and from Celgene, including romidepsin, pomalidomide, apremilast and PDA-001 (Celgene Cellular Therapeutics), are discussed. PMID:20191423

Gale, Sophie; Croasdell, Gary

2010-03-01

89

International team finds a bioactive protein from ancient medicinal plant may help combat melanoma and other cancers  

Cancer.gov

An international team led by scientists from the University of Medicine and Dentistry of New Jersey-School of Osteopathic Medicine, has found that a protein from the seeds of a plant used for centuries in traditional medicines may be able to halt the spread of melanoma, a lethal form of skin cancer. The study included collaborators from Nagoya University, the University of Michigan and GlaxoSmithKline. The University of Medicine and Dentistry of New Jersey is an academic affiliate of the Cancer Institute of New Jersey.

90

Safety and Immunogenicity of Early Vaccination with Two Doses of Tetravalent Measles-Mumps-Rubella-Varicella (MMRV) Vaccine in Healthy Children from 9 Months of Age  

Microsoft Academic Search

Background:  This open, randomized, controlled study [208136\\/018] assessed the safety and immunogenicity of early vaccination with an experimental\\u000a tetravalent measlesmumps-rubella-varicella (MMRV) vaccine (GlaxoSmithKline Biologicals) compared to concomitant administration\\u000a of separate licensed MMR (Priorix™) and varicella (Varilrix™) vaccines (MMR+V).\\u000a \\u000a \\u000a \\u000a Methods:  Vaccines were administered as a two-dose course in healthy children at 9 and 12 months of age (N = 153 in the MMRV

P. Goh; F. S. Lim; H. H. Han; P. Willems

2007-01-01

91

Near-coincident K-line and K-edge energies as ionization diagnostics for some high atomic number plasmas  

SciTech Connect

For some high atomic number atoms, the energy of the K-edge is tens of eVs higher than the K-line energy of another atom, so that a few eV increase in the line's energy results in a decreasing transmission of the x-ray through a filter of the matching material. The transmission of cold iridium's Asymptotically-Equal-To 63.287 keV K{alpha}{sub 2} line through a lutetium filter is 7% lower when emitted by ionized iridium, consistent with an energy increase of {Delta}{epsilon} Asymptotically-Equal-To 10{+-}1 eV associated with the ionization. Likewise, the transmission of the K{beta}{sub 1} line of ytterbium through a near-coincident K-edge filter changes depending on plasma parameters that should affect the ionization. Systematic exploration of filter-line pairs like these could become a unique tool for diagnostics of suitable high energy density plasmas.

Pereira, N. R. [Ecopulse, Inc., P.O. Box 528, Springfield, Virginia 22150 (United States); Weber, B. V.; Phipps, D. G.; Schumer, J. W. [Naval Research Laboratory, Washington, DC 20375 (United States); Seely, J. F. [Artep, Inc., 2922 Excelsior Springs Court, Ellicott City, Maryland 21042 (United States); Carroll, J. J. [Army Research Laboratory, Adelphi, Maryland 20873 (United States); Vanhoy, J. R. [United States Naval Academy, Annapolis, Maryland 21402 (United States); Slabkowska, K.; Polasik, M. [Faculty of Chemistry, Nicolaus Copernicus University, Gagarina 7, 87-100 Torun (Poland)

2012-10-15

92

Smith Purcell radiation from femtosecond electron bunches  

E-print Network

We present theoretical and experimental results from a Smith-Purcell radiation experiment using the electron beam from a 17 GHz high gradient accelerator. Smith- Purcell radiation occurs when a charged particle travels ...

Korbly, Stephen E

2005-01-01

93

STEVEN E. SMITH University of Arizona  

E-print Network

30 Gramas STEVEN E. SMITH University of Arizona Tucson, Arizona MARSHALL R. HAFERKAMP USDA herbivores on rangelands (Peden et al., 1974; Smith et al., 1996; Hart and Ashby, 1998; Sims and Risser, 2000

Smith, Steven E.

94

Fundamental Ideas of Mathematics Instructor: Sam Smith  

E-print Network

Math 225 Fundamental Ideas of Mathematics Syllabus Fall 2013 Instructor: Sam Smith Office: Barbelin 228, 610-660-1559, smith@sju.edu Office Hours: Tue, Thur 12:00-2:00 or by appointment. Text: Chartrand

Smith, Sam

95

Introducing Reference Semantics via Refinement Graeme Smith  

E-print Network

Introducing Reference Semantics via Refinement Graeme Smith Software Verification Research Centre, University of Queensland, Australia smith@svrc.uq.edu.au Abstract. Two types of semantics have been given

Smith, Graeme

96

Am I spikes over time? Leslie Smith  

E-print Network

Am I spikes over time? Leslie Smith Computing Science and Mathematics University of Stirling Stirling FK9 4LA, UK Email: l.s.smith@cs.stir.ac.uk URL: http://www.cs.stir.ac.uk/~lss Acknowledgements: EU

Smith, Leslie S.

97

Adversaries and Information Leaks Geoffrey Smith  

E-print Network

Adversaries and Information Leaks (Tutorial) Geoffrey Smith School of Computing and Information-Verlag Berlin Heidelberg 2008 #12;384 G. Smith ­ The program c has direct access to the sensitive information

Smith, Geoffrey

98

Stepwise Development from Ideal Specifications Graeme Smith  

E-print Network

Stepwise Development from Ideal Specifications Graeme Smith Software Verification Research Centre University of Queensland, Australia smith@svrc.uq.edu.au Abstract The stepwise development of a program using

Smith, Graeme

99

The RB Language Jonathan M. Smith  

E-print Network

­­ ­­ The RB Language Jonathan M. Smith Distributed Systems Laboratory Department of Computer of an attempt to generate more practical examples of the scheme described by Smith and Maguire for ``competitive

100

Towards robot audition Leslie S. Smith  

E-print Network

Towards robot audition Leslie S. Smith Department of Computing Science and Mathematics, University in illumination, and auditory systems can detect changes in room reverberation. #12;2 Leslie S. Smith Another key

Smith, Leslie S.

101

RANDALL KNOWLES SMITH High Energy Astrophysics Division  

E-print Network

., Foster, Adam, Smith, Randall K., Kat- suda, Satoru, Yoshii, Rie, 2012, Astrophysical Journal, 749, 137 9RANDALL KNOWLES SMITH High Energy Astrophysics Division Smithsonian Astrophysical Observatory, MS 2 / Edited Proceedings Handbook of X-ray Astronomy, K. A. Arnaud, R. K. Smith, & A. Siemiginowska 2011

102

BOUNDS FOR SPECTRAL CLUSTERS HART F. SMITH  

E-print Network

Lq BOUNDS FOR SPECTRAL CLUSTERS HART F. SMITH Abstract. In these notes, we review recent results] establish the same estimates under the assumption that the metric is C1,1. It is known by examples of Smith to the wave equation. The author was supported in part by NSF grant DMS-0140499. 1 #12;2 HART F. SMITH

Smith, Hart F.

103

La ideologización del pensamiento de Adam Smith  

Microsoft Academic Search

This paper examines the process of ideologization of Adam Smith’s thought. In The Wealth of Nations (1776), Smith embraced free enterprise as the foundational principle of nascent capitalism. The concept of the invisible hand –a metaphysical idea– helped give cohesion to a newborn science that offered a more dynamic and realistic explanation of the wealth of nations. The conceptual success

2009-01-01

104

The Coverage of Operational Scott F. Smith  

E-print Network

The Coverage of Operational Semantics Scott F. Smith Department of Computer Science The Johns (Talcott 1989), types and objects (Gordon and Rees 1996), and distributed objects (Agha, Mason, Smith text can 1 #12;2 Smith distinguish the two. This program text can be viewed as a particular "test

Smith, Scott F.

105

Math in Microbiology Hal L. Smith  

E-print Network

Math in Microbiology Hal L. Smith PSA 631 halsmith@asu.edu School of Mathematics and Statistics Arizona State University H.L.Smith (A.S.U.) Math in Microbiology Microbiology, January 2009 1 / 22 #12 for Nutrient 4 Bacteriophage and Bacteria in Chemostat 5 Food Chain H.L.Smith (A.S.U.) Math in Microbiology

Smith, Hal

106

Derek J. Smith Department of Computer Science  

E-print Network

Derek J. Smith Candidate Department of Computer Science Department This dissertation is approved, Modeling, and Application to Vaccine Design by Derek J. Smith B.Sc., Computer Science, University Mexico Albuquerque, New Mexico December 1997 #12;#12;c 1997, Derek J. Smith v #12;#12;For Dorothy, Mabel

Forrest, Stephanie

107

Arras User's Manual John B. Smith  

E-print Network

Arras User's Manual TR85-036 1985 John B. Smith The University of North Carolina at Chapel Hill'S MANUAL John B. Smith Department or Computer Science University or North Carolina Chapel Hill, North Carolina 27514 Copyright© 1984 by John B. Smith #12;Starling ARRAS Note for those not using TUCC: The ARRAS

North Carolina at Chapel Hill, University of

108

Smith & Franklin Academic Publishing Corporation  

E-print Network

Smith & Franklin Academic Publishing Corporation www.smithandfranklin.com Science, Religion in This World is the Human Soul? Science, Religion and Culture, 1(1):22-28 1 This paper draws upon my book, and to Union Theological Seminary in July 2013. #12;Science, Religion & Culture March 2014 | Volume 1 | Issue 1

Tong, Liang

109

Bacterial Growth H. L. Smith  

E-print Network

. Exercise 1 The gut bacteria E. coli can divide every thirty minutes when nutrients are abundantBacterial Growth H. L. Smith 1 Simple Models Bacteria are the dominant form of life on the planet but a source of sustenance for bacteria. Humans have learned to harness bacteria and other microbes to produce

Smith, Hal

110

Smith Mammal Body Mass Data  

NSDL National Science Digital Library

Data compiled on body mass information for 5731 mammalian species. Felisa A. Smith, S. Kathleen Lyons, S. K. Morgan Ernest, Kate E. Jones, Dawn M. Kaufman, Tamar Dayan, Pablo A. Marquet, James H. Brown, and John P. Haskell. 2003. Body mass of late Quaternary mammals. Ecology 84:3403

Ethel Stanley (Beloit College; Biology)

2009-01-10

111

Susan Krebs-Smith's biography  

Cancer.gov

Susan Krebs-Smith, PhD, is the Chief of the Risk Factor Monitoring and Methods Branch of the Applied Research Program. In that capacity, she oversees a program of research on the surveillance of risk factors related to cancer, methodological issues to improve the assessment of those factors, and issues related to guidance and food policy.

112

Adam Smith's Wealth of Nations  

Microsoft Academic Search

Adam Smith is considering as the founder of political economy owing to his book Inquiry into the Nature and Causes of the Wealth of Nations. From the pages of his book not only speaks the economist but also moral thinker, historian, sociologist and politics - one of the last poly-historians who demonstrates compass almost whole knowledge of his time and

Robert Holman

1997-01-01

113

Adam Smith's invisible hand argument  

Microsoft Academic Search

Adam Smith is usually thought to argue that the result of everyone pursuing their own interests will be the maximization of the interests of society. The invisible hand of the free market will transform the individual's pursuit of gain into the general utility of society. This is the invisible hand argument.

John D. Bishop

1995-01-01

114

November, 2006 Dear Mr Smith,  

E-print Network

30th November, 2006 Dear Mr Smith, I am writing, as your constituent from Oxford East, to raise (Templars Cowley) John Adams Institute for Accelerator Science Denys Wilkinson Building Keble Road OX1 3RH Email: n.delerue1@physics.ox.ac.uk for Accelerator Science J A I John Adams Institute

Crowther, Paul

115

Arthur Smith, Local Baptist Pastor.  

ERIC Educational Resources Information Center

Written and published by the students at Gary High School this volume has three articles dealing with East Texas life. The first "Arthur Smith" (David Hancock and others) is an account of growing up in Marian County, Texas is described by the local Baptist minister. The pastor begins with the year of his birth and gives detailed information about…

Heaton, Moss, Ed.

1985-01-01

116

The same face of the two Smiths: Adam Smith and Vernon Smith  

Microsoft Academic Search

Going from personal to impersonal exchange seems to be a relevant feature that allows humans to develop complex societies and grow prosperous. Adam Smith's idea of moral imagination, embodied in the impartial spectator and achieved through sympathy, may integrate and complement today's evolutionary biology and experimental economic explanations, providing the missing key as to how we generate and internalize those

Maria Pia Paganelli

2011-01-01

117

Econophysical visualization of Adam Smith’s invisible hand  

NASA Astrophysics Data System (ADS)

Consider a complex system whose macrostate is statistically observable, but yet whose operating mechanism is an unknown black-box. In this paper we address the problem of inferring, from the system’s macrostate statistics, the system’s intrinsic force yielding the observed statistics. The inference is established via two diametrically opposite approaches which result in the very same intrinsic force: a top-down approach based on the notion of entropy, and a bottom-up approach based on the notion of Langevin dynamics. The general results established are applied to the problem of visualizing the intrinsic socioeconomic force-Adam Smith’s invisible hand-shaping the distribution of wealth in human societies. Our analysis yields quantitative econophysical representations of figurative socioeconomic forces, quantitative definitions of “poor” and “rich”, and a quantitative characterization of the “poor-get-poorer” and the “rich-get-richer” phenomena.

Cohen, Morrel H.; Eliazar, Iddo I.

2013-02-01

118

Street & Smith's Preservation Access Project  

NSDL National Science Digital Library

For thousands of Americans throughout the 19th and early 20th centuries, dime novels and pulp magazines were their first experiences with the emerging world of mass-produced material culture. One such purveyor was the Street & Smith publishing house, which began in 1855 and published a wide variety of popular literature (such as homemaking magazines, comics, and dime novels) for over 100 years. These products didn't often have a great deal of originality, as the company viewed fiction as a commodity, and editors dictated plots and characters to writers, a list that included Horatio Alger, Upton Sinclair, and Jack London. This Web site, an online exhibit presented by the Syracuse University Library, pays homage to this publishing house with a number of scanned digitized images of the Street & Smith dime novels, a cover art gallery, and a collection of images immortalizing that most famous comic strip character, the Yellow Kid.

119

Fukushima to receive Smith Medal  

NASA Astrophysics Data System (ADS)

The 1990 Waldo E. Smith Medal for extraordinary service to geophysics will be given to Naoshi Fukushima, who earned an international reputation for his pioneering work in geomagnetic disturbance and ionospheric electric currents. Now retired from the University of Tokyo, Japan, Fukushima is being cited for his public service to international geophysics, and, in particular, his contributions to the International Association of Geomagnetism and Aeronomy, of which he was Secretary General from September 1975 to August 1983.The Smith Medal will be presented as part of the AGU Fall Meeting Honors Night festivities, Wednesday, December 5, in San Francisco, Calif. Three James B. Macelwane Medals, the John Adam Fleming Medal, and the Maurice Ewing Medal will also be presented (see Eos, February 20, 1990, p. 294).

120

GPU Accelerated Smith-Waterman  

SciTech Connect

We present a novel hardware implementation of the double affine Smith-Waterman (DASW) algorithm, which uses dynamic programming to compare and align genomic sequences such as DNA and proteins. We implement DASW on a commodity graphics card, taking advantage of the general purpose programmability of the graphics processing unit to leverage its cheap parallel processing power. The results demonstrate that our system's performance is competitive with current optimized software packages.

Liu, Y; Huang, W; Johnson, J; Vaidya, S

2006-02-08

121

William Smith (1769-1839)  

NSDL National Science Digital Library

This brief history of William Smith, who initiated the Principle of Faunal Succession, covers his early education, his employment as an assistant surveyor to Edward White, and his time as construction supervisor of the Somerset Canal in southwestern England. The text explains his production of a geological map of England and final recognition in 1831, when he received the Wollaston Medal, the highest honor awarded each year for outstanding achievement in geology by the Geological Society of London.

122

Richard Smith, Director smith@sfu.ca Adam Holbrook, Associate Director  

E-print Network

CONTACT Richard Smith, Director smith@sfu.ca Adam Holbrook, Associate Director jholbroo Clayman Andrew Feenberg Andy Hira Adam Holbrook Martin Laba Brian Lewis Elicia Maine Stelvia Matos Ian McCarthy Roman Onufrijchuk Richard Smith David Zandvliet RESEARCHERS & ASSOCIATES Nancy Duxbury Gordon Gow

123

Risk communication: the Avandia case, a pilot study.  

PubMed

On 21 May 2007, the New England Journal of Medicine published Nissen and Wolski's article entitled 'Effect of rosiglitazone on the risk of myocardial infarcation and death from cardiovascular causes.' The publication of the article had immediate ramifications. The producer of rosiglitazone (under the trademark Avandia(®)); GlaxoSmithKline, saw its share price fall 8% on the day of the publication, and it led to front-page headlines in national newspapers in Europe and North America. This article evaluates the risk-communication strategies of the various actors involved in the Avandia case from the time of the Nissen and Wolski article to the present day. The evaluation is based on a content analysis of a number of USA and UK newspapers from the period January 2007 to May 2008, interviews with GlaxoSmithKline staff, drug regulators (EMEA, Medicines and Healthcare Products Regulatory Agency and US FDA), journalists at the Wall Street Journal and the Financial Times, and advisors to US politicians (Congressional staffers). PMID:22111531

Lofstedt, Ragnar

2010-01-01

124

Pricing strategies for combination pediatric vaccines and their impact on revenue: Pediarix or Pentacel?  

PubMed

This paper analyzes pricing strategies for pediatric combination vaccines and their impact on the United States pediatric vaccine market. Three pharmaceutical companies compete pairwise with each other over the sale of vaccines containing two or three antigens per injection. Specific emphasis is placed on examining the competition between two pentavalent vaccines: GlaxoSmithKline's Pediarix (DTaP-HepB-IPV) and Sanofi Pasteur's Pentacel (DTaP-IPV/Hib). The main contribution of the paper is to provide a methodology for analyzing pricing strategies of directly competing, partially overlapping, and mutually exclusive combination vaccines in the United States pediatric vaccine market, with the goal of maximizing each pharmaceutical company's expected revenue. The resulting analysis shows that Pentacel is not competitively priced when compared to Pediarix, its strongest competitor, for federal contract prices ending 31 March 2010. Accordingly, Sanofi Pasteur should expect to generate low revenue upon market entry, while Pediarix remains well priced, with GlaxoSmithKline able to generate a high level of revenue at the expense of Sanofi Pasteur. The proposed pricing approach suggests an appropriate price for Pentacel whereby a substantial increase in expected revenue can be realized. PMID:20402282

Robbins, Matthew J; Jacobson, Sheldon H; Sewell, Edward C

2010-03-01

125

PROPAGATION OF SINGULARITIES FOR ROUGH METRICS HART F. SMITH  

E-print Network

PROPAGATION OF SINGULARITIES FOR ROUGH METRICS HART F. SMITH Abstract. We use a wave packet the Simons Foundation (# 266371 to Hart Smith). 1 #12;2 HART F. SMITH H¨ormander's theorem [9] on propagation

Smith, Hart F.

126

ON MONOIDS WITH A SINGLE DEFINING RELATOR G. C. Smith  

E-print Network

. Smith Abstract. This paper concerns single-relator monoid presentations, and di* *scusses Eileen and Roy Smith on the occasion of their Golden Wedding Anniversary;2 G. C. SMITH Results The first result shows that Johnson

Smith, Geoff

127

Genetics Home Reference: Smith-Lemli-Opitz syndrome  

MedlinePLUS

... PubMed Recent literature OMIM Genetic disorder catalog Conditions > Smith-Lemli-Opitz syndrome On this page: Description Genetic ... names Glossary definitions Reviewed July 2007 What is Smith-Lemli-Opitz syndrome? Smith-Lemli-Opitz syndrome is ...

128

33 CFR 117.841 - Smith Creek.  

Code of Federal Regulations, 2010 CFR

...Navigable Waters 1 2010-07-01 2010-07-01 false Smith Creek. 117.841 Section 117.841 Navigation and Navigable...REGULATIONS Specific Requirements North Carolina § 117.841 Smith Creek. The draw of the S117-S133 Bridge, mile...

2010-07-01

129

33 CFR 117.841 - Smith Creek.  

Code of Federal Regulations, 2013 CFR

...Navigable Waters 1 2013-07-01 2013-07-01 false Smith Creek. 117.841 Section 117.841 Navigation and Navigable...REGULATIONS Specific Requirements North Carolina § 117.841 Smith Creek. The draw of the S117-S133 Bridge, mile...

2013-07-01

130

33 CFR 117.841 - Smith Creek.  

Code of Federal Regulations, 2011 CFR

...Navigable Waters 1 2011-07-01 2011-07-01 false Smith Creek. 117.841 Section 117.841 Navigation and Navigable...REGULATIONS Specific Requirements North Carolina § 117.841 Smith Creek. The draw of the S117-S133 Bridge, mile...

2011-07-01

131

33 CFR 117.841 - Smith Creek.  

Code of Federal Regulations, 2012 CFR

...Navigable Waters 1 2012-07-01 2012-07-01 false Smith Creek. 117.841 Section 117.841 Navigation and Navigable...REGULATIONS Specific Requirements North Carolina § 117.841 Smith Creek. The draw of the S117-S133 Bridge, mile...

2012-07-01

132

33 CFR 117.841 - Smith Creek.  

Code of Federal Regulations, 2014 CFR

...Navigable Waters 1 2014-07-01 2014-07-01 false Smith Creek. 117.841 Section 117.841 Navigation and Navigable...REGULATIONS Specific Requirements North Carolina § 117.841 Smith Creek. The draw of the S117-S133 Bridge, mile...

2014-07-01

133

Forensic Entomology & Taphonomy Smith Hall Room 125  

E-print Network

ENTM 295T Forensic Entomology & Taphonomy Smith Hall Room 125 Monday 8:30 ­ 11:20 a.m. Fall and on the postmortem fate of human remains. Ralph Williams, Ph.D. D-ABFE Professor of Entomology Entomology, Smith B9

Ginzel, Matthew

134

Bringing Sally Smith's Vision to Manayunk  

ERIC Educational Resources Information Center

In this article, the author narrates her application of what she learned from her internship at Sally Smith's Lab School of Washington to her new school and shares the favorable impact it had brought on her teaching career. The author shares her first exposure to the powerful effects of Smith's "Live It, Learn It" methodology as she encountered a…

Ford, Jackie

2010-01-01

135

The Treatment of Smith's Invisible Hand  

ERIC Educational Resources Information Center

Adam Smith used the metaphor of an invisible hand to represent the instincts of human nature that direct behavior. Moderated by self-control and guided by proper institutional incentives, actions grounded in instincts can be shown to generate a beneficial social order even if not intended. Smith's concept, however, has been diluted and distorted…

Wight, Jonathan B.

2007-01-01

136

The Treatment of Smith's Invisible Hand1  

Microsoft Academic Search

Adam Smith's metaphor of an invisible hand represents the instincts of human nature that direct behavior. Moderated by self-control and guided by proper institutional incentives, actions grounded in instincts can be shown to generate a beneficial social order even if not intended. Smith's concept, however, has been diluted and distorted over time through extension and misuse. Common misperceptions are that

Jonathan B. Wight

2006-01-01

137

The hidden theology of Adam Smith  

Microsoft Academic Search

This paper contests late readings of Adam Smith's 'invisible hand' as an essentially secular device. It is argued that Smith's social and economic philosophy is inherently theological and that his entire model of social order is logically dependent on the notion of God's action in nature. It will be shown that far from being a purely secular, materialist or evolutionist

Lisa Hill

2001-01-01

138

The Treatment of Smith's Invisible Hand  

Microsoft Academic Search

Adam Smith used the metaphor of an invisible hand to represent the instincts of human nature that direct behavior. Moderated by self-control and guided by proper institutional incentives, actions grounded in instincts can be shown to generate a beneficial social order even if not intended. Smith's concept, however, has been diluted and distorted over time through extension and misuse. Common

Jonathan B. Wight

2007-01-01

139

Adam Smith and the Rhetoric of Style.  

ERIC Educational Resources Information Center

Historians of rhetoric have generally accepted the view that Adam Smith rejected the principles of classical rhetoric. However, while there can be no doubt that Smith greatly truncated the five classical arts of rhetoric (invention, arrangement, style, memory, and delivery) by reducing his concerns largely to style and arrangement, he did not…

Moran, Michael G.

140

Environmental assessment: Deaf Smith County site, Texas  

SciTech Connect

In February 1983, the US Department of Energy (DOE) identified a location in Deaf Smith County, Texas, as one of nine potentially acceptable sites for a mined geologic repository for spent nuclear fuel and high-level radioactive waste. To determine their suitability, the Deaf Smith County site and the eight other potentially sites have been evaluated in accordance with the DOE's General Guidelines for the Recommendation of Sites for the Nuclear Waste Repositories. The Deaf Smith County site is in the Permian Basin, which is one of five distinct geohydrologic settings considered for the first repository. On the basis of the evaluations reported in this EA, the DOE has found that the Deaf Smith County site is not disqualified under the guidelines. On the basis of these findings, the DOE is nominating the Deaf Smith County site as one of the five sites suitable for characterization. 591 refs., 147 figs., 173 tabs.

Not Available

1986-05-01

141

A Survey of Process Migration Mechanisms Jonathan M. Smith  

E-print Network

A Survey of Process Migration Mechanisms Jonathan M. Smith Computer Science Department Columbia Migration Mechanisms Jonathan M. Smith Computer Science Department Columbia University New York, NY 10027

Smith, Jonathan M.

142

Career Statement Noah A. Smith (nasmith@cs.cmu.edu)  

E-print Network

Career Statement Noah A. Smith (nasmith@cs.cmu.edu) Abstract Modulo formatting, this document-to-text transformations [Das and Smith, 2009; Heilman and Smith, 2010], including my former Ph.D. student Michael Heilman's dissertation project; and dynamic programming extensions [Cohen et al., 2008b; Gimpel and Smith, 2009a]). 1

Smith, Noah

143

Environmental assessment: Deaf Smith County site, Texas  

SciTech Connect

In February 1983, the US Department of Energy (DOE) identified a location in Deaf Smith County, Texas, as one of the nine potentially acceptable sites for mined geologic repository for spent nuclear fuel and high-level radioactive waste. To determine their suitability, the Deaf Smith County site and eight other potentially acceptable sites have been evaluated in accordance with the DOE's General Guidelines for the Recommendation of Sites for the Nuclear Waste Repositories. The Deaf Smith County site is in the Permian Basin, which is one of five distinct geohydrologic settings considered for the first repository. On the basis of the evaluations reported in this EA, the DOE has found that the Deaf Smith County site is not disqualified under the guidelines.

Not Available

1986-05-01

144

Shea receives Waldo E. Smith medal  

NASA Astrophysics Data System (ADS)

Margaret (Peggy) Shea was awarded the Waldo E.Smith Medal at the AGU Fall Meeting Honors Ceremony, which was held on December 8, 1998, in San Francisco, California. The medal recognizes extraordinary service to geophysics.

Russell, Christopher; Shea, Margaret A.

145

Environmental assessment, Deaf Smith County site, Texas  

SciTech Connect

The Nuclear Waste Policy Act of 1982 (42 USC sections 10101-10226) requires the environmental assessment of a proposed site to include a statement of the basis for nominating a site as suitable for characterization. Volume 2 provides a detailed statement evaluating the site suitability of the Deaf Smith County Site under DOE siting guidelines, as well as a comparison of the Deaf Smith County Site to the other sites under consideration. The evaluation of the Deaf Smith County Site is based on the impacts associated with the reference repository design, but the evaluation will not change if based on the Mission Plan repository concept. The second part of this document compares the Deaf Smith County Site to Davis Canyon, Hanford, Richton Dome and Yucca Mountain. This comparison is required under DOE guidelines and is not intended to directly support subsequent recommendation of three sites for characterization as candidate sites. 259 refs., 29 figs., 66 refs. (MHB)

Not Available

1986-05-01

146

Turgot en Smith; een paar apart  

Microsoft Academic Search

Anne-Claire Hoyng deed onderzoek naar het boek The Wealth of Nations van Adam Smith (1723-1790). Ze concludeert dat Smith voor het schrijven van zijn boek een werk van de Fransman Anne-Robert Jacques Turgot (1727-1781) als inspiratiebron gebruikte (Réflexions sur la Formation et la distribution des Richesses). Turgot was onder meer minister van Financiën onder Lodewijk de XVI. Hoyng wijst op

A.-C. Hoyng

2011-01-01

147

Smith-Lemli-Opitz Syndrome  

PubMed Central

Smith-Lemli-Opitz syndrome (SLOS) is a multiple congenital malformation/intellectual disability syndrome, with clinical characteristics encompassing a wide spectrum and great variability. Elucidation of the biochemical and molecular genetic basis for the autosomal recessively inherited SLOS, specifically, understanding SLOS as a cholesterol deficiency syndrome caused by mutations in DHCR7, opened up enormous possibilities for therapeutic intervention. When cholesterol was discovered to be the activator of sonic hedgehog, cholesterol deficiency with inactivation of this developmental patterning gene was thought to be the cause of SLOS malformations, yet this explanation is overly simplistic. Still, despite these important research breakthroughs, there is no proven treatment for SLOS. Better animal models are needed to allow potential treatment testing and the study of disease pathophysiology, which is incompletely understood. Creation of human cellular models will surely be useful, especially models of brain cells. In vivo human studies are essential as well. There have only been limited natural history studies of SLOS to date. Biomarker development will be critical in facilitating clinical trials in this rare condition, since clinical phenotype may change over many years. Additional research in these and other areas is critical if we are to make headway towards ameloriating the effects of this devastating condition. PMID:21777499

DeBarber, Andrea E.; Eroglu, Yasemen; Merkens, Louise S.; Pappu, Anuradha S.; Steiner, Robert D.

2012-01-01

148

The Devil in Mr. Smith: A Conversation with Jonathan Z. Smith  

ERIC Educational Resources Information Center

This interview was recorded in November 2012 in Jonathan Z. Smith's Hyde Park graystone. Professor Smith offers insights into how he thinks about his classroom teaching and his students' learning through descriptions of various assignments and classroom activities he has developed over more than forty years of teaching. The discussion…

Smith, Jonathan Z.; Pearson, Thomas; Gallagher, Eugene V.; Jensen, Tim; Fujiwara, Satoko

2014-01-01

149

Processing Semblances Induced through Inter-Postsynaptic Functional LINKs, Presumed Biological Parallels of K-Lines Proposed for Building Artificial Intelligence  

PubMed Central

The internal sensation of memory, which is available only to the owner of an individual nervous system, is difficult to analyze for its basic elements of operation. We hypothesize that associative learning induces the formation of functional LINK between the postsynapses. During memory retrieval, the activation of either postsynapse re-activates the functional LINK evoking a semblance of sensory activity arriving at its opposite postsynapse, nature of which defines the basic unit of internal sensation – namely, the semblion. In neuronal networks that undergo continuous oscillatory activity at certain levels of their organization re-activation of functional LINKs is expected to induce semblions, enabling the system to continuously learn, self-organize, and demonstrate instantiation, features that can be utilized for developing artificial intelligence (AI). This paper also explains suitability of the inter-postsynaptic functional LINKs to meet the expectations of Minsky’s K-lines, basic elements of a memory theory generated to develop AI and methods to replicate semblances outside the nervous system. PMID:21845180

Vadakkan, Kunjumon I.

2011-01-01

150

STS-110 Crew Interviews: Steve Smith  

NASA Technical Reports Server (NTRS)

STS-110 Mission Specialist Steve Smith is seen during this preflight interview, where he gives a quick overview of the mission before answering questions about his inspiration to become an astronaut and his career path. Smith outlines his role in the mission in general, and specifically during the docking and extravehicular activities (EVAs). He describes the payload (S0 Truss and Mobile Transporter) and the dry run installation of the S0 truss that will take place the day before the EVA for the actual installation. Smith discusses the planned EVAs in detail and outlines what supplies will be left for the resident crew of the International Space Station (ISS). He ends with his thoughts on the most valuable aspect of the ISS.

2002-01-01

151

The legendary Smiths and their Paris hospital.  

PubMed

The Paris Hospital in Paris, Arkansas, provided high quality care during its existence from 1910 to 1971, offering a prepaid health care plan from 1920 to 1971. Three generations of Smith doctors were its nucleus, subsidizing the annual losses of the hospital and providing care to all, regardless of ability to pay. The hospital was a community unto itself for the nurses who lived, trained, and worked there. A unique family in the history of medicine in Arkansas, the Smith physicians were well trained, altruistic, compassionate, and conscientious, exemplifying the traditional values of twentieth century medical practice. PMID:25665254

Prewitt, Taylor; Smith, John C; Bell, J P

2015-01-01

152

STS-103 Crew Interviews: Steven Smith  

NASA Technical Reports Server (NTRS)

Live footage of a preflight interview with Mission Specialist Steven L. Smith is seen. The interview addresses many different questions including why Brown became an astronaut, the events that led to his interest, any role models that he had, and his inspiration. Other interesting information that this one-on-one interview discusses is an explanation of the why this required mission to service the Hubble Space Telescope must take place at such an early date, replacement of the gyroscopes, transistors, and computers. Also discussed is Smith's responsibility during any of the planned space walks scheduled for this mission.

1999-01-01

153

!! ARI No. 32 (2009) Odontoponera denticulata (F. Smith) (Formicidae: Ponerinae),  

E-print Network

!! ARI No. 32 (2009) " #!" Odontoponera denticulata (F. Smith) (Formicidae: Ponerinae), a distinct-shi, 890-0065 Japan !" #$% &'()*+,-./0123456.6789: Odontoponera denticulata (F. Smith) );? 123456.6@ Odontoponera )ASmith)VWX YOZ

Villemant, Claire

154

Organizzato da: Christopher Smith, British School at Rome  

E-print Network

Organizzato da: Christopher Smith, British School at Rome Attilio Mastrocinque, Università di LIPPOLIS, Attilio MASTROCINQUE, Christopher SMITH - Presentazione 10.00 ­ 10.30 Elio LO CASCIO - I fora e

Guidoni, Leonardo

155

Dual Models of Permutation Problems Barbara M. Smith  

E-print Network

Dual Models of Permutation Problems Barbara M. Smith School of Computing & Mathematics University of Huddersfield Huddersfield HD1 3DH, U.K. b.m.smith@hud.ac.uk Abstract. A constraint satisfaction problem

Smith, Barbara M.

156

Rapid location of mount points JONATHAN M. SMITH  

E-print Network

­­ ­­ Rapid location of mount points JONATHAN M. SMITH Computer Science Department, Columbia ``core'' is ``/u2/smith/core''. The current directory is a directory­valued variable. It is an implied

157

Principles of Secure Information Flow Analysis Geoffrey Smith  

E-print Network

Principles of Secure Information Flow Analysis Geoffrey Smith School of Computing and Information to explain the #12;2 Geoffrey Smith principles underlying secure information flow analysis and to discuss

Smith, Geoffrey

158

The Task of the Referee Alan Jay Smith  

E-print Network

The Task of the Referee * Alan Jay Smith Computer Science Division EECS Department University professional. Typically, referees learn to ¡ ¡ ¡ ¡ ¡ ¡ ¡ ¡ ¡ ¡ ¡ ¡ ¡ ¡ ¡ ¡ ¡ * Prof. Smith's research

Torr, Philip H. S.

159

Specifying mode requirements of embedded systems Graeme Smith  

E-print Network

Specifying mode requirements of embedded systems Graeme Smith Software Verification Research Centre University of Queensland, Australia Email: smith@svrc.uq.edu.au Abstract This paper presents a formal

Smith, Graeme

160

Another Distortion of Adam Smith: The Case of the \\  

Microsoft Academic Search

This paper addresses a major omission in the way textbook writers and journalists utilize Adam Smith’s concept of the “invisible hand” to make Adam Smith an intellectual precursor of modern neo-liberal economic policy. Specifically, the paper addresses the use of the concept of the “invisible hand” by Adam Smith to address two major issues in the debate over neo-liberal policy:

Michael Meeropol

2004-01-01

161

Adam Smith, Behavioral Economist Nava Ashraf, Colin F. Camerer and  

E-print Network

Adam Smith, Behavioral Economist Nava Ashraf, Colin F. Camerer and George Loewenstein I n The Wealth of Nations, published in 1776, Adam Smith famously argued that economic behavior was motivated over whether Adam Smith's view of human motivation as expressed in The Theory of Moral Sentiments

Greer, Julia R.

162

Working Papers m 2011:04 Rediscovering Adam Smith  

E-print Network

Working Papers m 2011:04 Rediscovering Adam Smith HowThe Theory of Moral Sentiments canexplainemergingevidencein experimentaleconomics Douglas E. Stevens #12;AdamSmithResearchFoundation Working Papers Series.AuthorsareadvisedtokeepinmindthegeneralistaudienceoftheWorkingPapersseries andavoidtechnicallanguageandextensivefootnotesasmuchaspossible. m TheAdamSmithResearchFoundation(ASRF)isbasedwithintheCollegeofSocialSciencesat the

Guo, Zaoyang

163

Mark Smith KTH School of ICT IS2500: RFID Systems  

E-print Network

Mark Smith KTH School of ICT IS2500: RFID Systems RFID stands for Radio Frequency Identification devices with you right now. #12;Mark Smith KTH School of ICT RFID is a big business It is very significant Market 2010 Rest of World North America East Asia Europe 2.6% 34.2% 26.1% 37.1% #12;Mark Smith KTH School

Maguire Jr., Gerald Q.

164

Adam Smith, Stoicism and religion in the 18th century  

Microsoft Academic Search

This article explores the influence of Stoicism and religion on Adam Smith. While other commentators have argued either that the main influence on Smith was Stoicism or that it was religion, the two influences have not been explicitly linked. In this article I attempt to make such a link, arguing that Smith can be seen as belonging to the strand

P. H. Clarke

2000-01-01

165

SMITH AND BARGHNONCONSCIOUS EFFECTS OF POWER NONCONSCIOUS EFFECTS OF POWER  

E-print Network

SMITH AND BARGHNONCONSCIOUS EFFECTS OF POWER NONCONSCIOUS EFFECTS OF POWER ON BASIC APPROACH AND AVOIDANCE TENDENCIES Pamela K. Smith Radboud University Nijmegen John A. Bargh Yale University According-24 Address for correspondence: Pamela K. Smith, Department of Social Psychology, Behavioural Science

Bargh, John A.

166

J. E. SMITH1, 2 , L. KORSTEN1  

E-print Network

230 J. E. SMITH1, 2 , L. KORSTEN1 AND T. A. S. AVELING2 " Department of Microbiology and Plant of a new anthracnose disease of cowpea (Vigna unguiculata (L.) Walp.) in South Africa (Smith & Aveling. Sunken, necrotic lesions and small black acervuli are visible on the stems (Smith & Aveling, 1997). Three

167

Petition of Nancy Smith for Clemency OHIO PAROLE BOARD  

E-print Network

Petition of Nancy Smith for Clemency OHIO PAROLE BOARD APPLICATION AND MEMORANDUM IN SUPPORT, Justin Sommers, Davis Polk & Wardwell LLP CC: Dennis Will, Lorain County Prosecutor Re: Nancy Smith Date respectfully to urge the grant of a pardon, or alternatively a commutation of sentence, to Nancy Smith, a woman

Papautsky, Ian

168

an interview with Richard Alba Extraordinary Lives: Patti Smith  

E-print Network

When racial boundaries fade an interview with Richard Alba Extraordinary Lives: Patti Smith What on the workforce, the family, and American society. EXTRAORDINARY LIVES: PATTI SMITH 12 This was the first featured the maximally talented Patti Smith--singer, songwriter, artist and poet--who spoke thoughtfully

Dennehy, John

169

Marjorie V. Smith Compiled by Margot St. Louis (1979)  

E-print Network

Marjorie V. Smith fonds Compiled by Margot St. Louis (1979) Revised by Erwin Wodarczak (2004 Catalogue entry (UBC Library catalogue) #12; Fonds Description Marjorie V. Smith fonds. ­ 19581973 Marjorie V. Smith was the program director for the Aging and Human Relations Division at UBC's Centre

Handy, Todd C.

170

Dorothy Blakey Smith Compiled by April Haddad (1980)  

E-print Network

Dorothy Blakey Smith fonds Compiled by April Haddad (1980) Last revised October 2012 University (UBC Library catalogue) #12;Fonds Description Dorothy Blakey Smith fonds. ­ 1919-1978. 72 cm of textual records. 78 photographs. Biographical Sketch Born in Leeds, England, Dorothy Blakey Smith immigrated

Handy, Todd C.

171

Wednesday, December 10 4:00 Rebecca Rideout (Bruce Smith)  

E-print Network

Wednesday, December 10 4:00 Rebecca Rideout (Bruce Smith) What's for Dinner? The effect of mite (Bruce Smith) The influence of light polarization on photopositive response of zooplankton 4:30 Drew Bradshaw (Andy Smith) SUMMER RESEARCH PROJECT Effects of oxidation in glue protein 4:45 ­ 5:15 Caitlin

172

Friday March 8th, 2013 Michael Smith Building  

E-print Network

Friday March 8th, 2013 9am to 3pm Michael Smith Building (main floor) 2185 East Mall UBC Register Online! bioteach.ubc.ca The Michael Smith Laboratories are pleased to announce a one day Scientific Smith Labs. We can accommodate up to 100 students and registration is free of charge. To enroll, please

Handy, Todd C.

173

Embodied Attention and Word Learning by Toddlers Linda B. Smith  

E-print Network

1 Embodied Attention and Word Learning by Toddlers Chen Yu Linda B. Smith Department, & Tenenbaum, 2009; Quine, 1964; Smith & Yu, 2008; Snedeker & Gleitman, 2004; Waxman & Booth, 2001 mechanisms that evaluate data across many word-scene experiences (Frank et al., 2009; Smith & Yu, 2008; Yu

Yu, Chen

174

TWO NEW SPECIES OF THE ANT GENUS PERISSOMYRMEX SMITH  

E-print Network

TWO NEW SPECIES OF THE ANT GENUS PERISSOMYRMEX SMITH (HYMENOPTERA: FORMICIDAE) FROM CHINA1 Shanyi Zhou2 and Jianhua Huang3 ABSTRACT: Two new species of the ant genus Perissomyrmex Smith are described, China The ant genus Perissomyrmex was described by M. R. Smith in 1947 based on the type species P

Villemant, Claire

175

Elliott Dunlap Smith Award for Distinguished Teaching and Educational Service  

E-print Network

1 Elliott Dunlap Smith Award for Distinguished Teaching and Educational Service Dietrich College The Elliott Dunlap Smith Award is presented annually to a regular faculty member in the Dietrich College than those directly taught. #12;3 A Suggested Nomination Packet Outline for the Elliott Dunlap Smith

Andrews, Peter B.

176

Tanya M. Smith Department of Human Evolutionary Biology  

E-print Network

1 Tanya M. Smith Department of Human Evolutionary Biology Harvard University 11 Divinity Avenue Research Grant, 1995. Peer-Reviewed Publications 56. Le Cabec, A., Smith, T.M., Tang, N. Tafforeau, P. (in, E., Kunimatsu, Y., Hirasaki, E., Shimizu, D., Smith, T.M. (in review). Ecological signals in molar

Smith, Tanya M.

177

Evolutionary Ecology Research, 2001, 3: 595602 2001 Felisa A. Smith  

E-print Network

Evolutionary Ecology Research, 2001, 3: 595­602 © 2001 Felisa A. Smith Fitness trade-offs select for semelparous reproduction in an extreme environment Felisa A. Smith* and Eric L. Charnov Department of Biology@unm.edu Consult the copyright statement on the inside front cover for non-commercial copying policies. #12;Smith

Smith, Felisa A.

178

Tanya M. Smith Department of Human Evolutionary Biology  

E-print Network

1 Tanya M. Smith Department of Human Evolutionary Biology Peabody Museum 47 11 Divinity Avenue, D.J., Larsen, C.S., Hutchinson, D., Smith, T.M. (in review) Chronology of linear enamel hypoplasia.) The Krapina Teeth. Croatian Natural History Museum, Zagreb. #12;2 49. Smith, T.M., Alemseged, Z. (in press

Smith, Tanya M.

179

Wunderlich, Kaufman, and Smith LINK TRAVEL TIME PREDICTION FOR  

E-print Network

Wunderlich, Kaufman, and Smith 1 LINK TRAVEL TIME PREDICTION FOR DECENTRALIZED ROUTE GUIDANCE@att.com Robert L. Smith University of Michigan Department of Industrial and Operations Engineering Ann Arbor, MI-dating process is utilized to insure the discovery of a stable #12;Wunderlich, Kaufman, and Smith 2 routing after

Smith, Robert L.

180

Mathematics of Games and Politics Instructor: Sam Smith, Mathematics  

E-print Network

Math 132 Mathematics of Games and Politics Syllabus Fall 2010 Instructor: Sam Smith, Mathematics Office Barbelin 212, 610-660-1559, smith@sju.edu Office Hours: Mon 11:30-1:00, Tue 1:00-4:00 or by appointment. Text: Sam Smith, The Mathematics of Games and Politics, available for purchase at the University

Smith, Sam

181

Tanya M. Smith Department of Human Evolutionary Biology  

E-print Network

1 Tanya M. Smith Department of Human Evolutionary Biology Harvard University 11 Divinity Avenue. * SUNY Geneseo Foundation Research Grant, 1995. #12;2 Peer-Reviewed Publications 52. Smith, T.M. (in., Stinespring Harris, A., Reid, D.J., Larsen, C.S., Hutchinson, D., Smith, T.M. (in review) Chronology of linear

Smith, Tanya M.

182

WaveCurrent Interactions in Finite Depth JEROME A. SMITH  

E-print Network

Wave­Current Interactions in Finite Depth JEROME A. SMITH Scripps Institution of Oceanography, La (Longuet-Higgins 1969; Hasselmann 1971; Garrett and Smith 1976; and many others). In particular, Hassel) changes in wave momentum that absorb some of the radiation stress gradients. Garrett and Smith (1976

Smith, Jerome A.

183

Deborah K. Smith Department of Geology and Geophysics, MS 22  

E-print Network

Deborah K. Smith Department of Geology and Geophysics, MS 22 Woods Hole Oceanographic Institution: Jordan, T. H., H. W. Menard, and D.K. Smith, Density and size distribution of seamounts in the eastern. Smith, H. W. Menard, J. A. Orcutt and T. H. Jordan, Seismic reflection site survey: correlation

Smith, Deborah K.

184

Tanya M. Smith Department of Human Evolutionary Biology  

E-print Network

1 Tanya M. Smith Department of Human Evolutionary Biology Harvard University 11 Divinity Avenue Foundation Research Grant, 1995. Peer-Reviewed Publications 55. Le Cabec, A., Smith, T.M., Tafforeau, P. (in., Reid, D.J., Larsen, C.S., Hutchinson, D., Smith, T.M. (in review) Chronology of linear enamel

Smith, Tanya M.

185

RESEARCH ARTICLE Matthew W. Bettridge Barton L. Smith  

E-print Network

RESEARCH ARTICLE Matthew W. Bettridge Ã? Barton L. Smith Robert E. Spall Aerodynamic jet steering of the suction flow is entrained. Vectoring with multiple suction and blowing slots was reported by Smith et al was investigated experimentally by Smith and Glezer (2002) and numerically by Guo et al. (2002, 2003). Synthetic

Smith, Barton L.

186

Adam Smith: managerial insights from the father of economics  

Microsoft Academic Search

Purpose – The paper aims to apply the ideas found in the paper of Adam Smith, the pre-eminent eighteenth century economist, to the field of management. Design\\/methodology\\/approach – The paper provides a brief biography of Smith, summarizes his main contributions, and then applies them to contemporary management practices. Findings – Adam Smith was the first person to identify specialization and

George R. Crowley; Russell S. Sobel

2010-01-01

187

SMITH FARM FROM CEMETERY HILL, LOOKING SOUTHWEST. (This image shows ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

SMITH FARM FROM CEMETERY HILL, LOOKING SOUTHWEST. (This image shows the Smith Farm in the center of Ebey?s Prairie. Ebey?s Landing and the Puget Sound can be seen on the right. Farmers from the Sherman-Bishop Dairy are visible at the bottom left, cutting hay.) - Smith Farm, 399 Ebey Road, Coupeville, Island County, WA

188

Computation of Hermite and Smith Normal Forms of Matrices  

E-print Network

Computation of Hermite and Smith Normal Forms of Matrices; Abstract We study the problem of computing Hermite and Smith normal forms of ma- trices over. One first result is a fast Las Vegas probabilistic algorithm to compute the * *Smith normal form

Storjohann, Arne

189

Numerical algorithms for the computation of the Smith normal  

E-print Network

Numerical algorithms for the computation of the Smith normal form of integral matrices C of the Smith normal form of integral matrices are described. More specifically, the com­ pound matrix method of the algorithms. AMS Subject Classification: Primary 65F30, Secondary 15A21, 15A36. Key words and phrases: Smith

Seberry, Jennifer

190

Using Gazetteers in Discriminative Information Extraction Andrew Smith  

E-print Network

Using Gazetteers in Discriminative Information Extraction Andrew Smith Division of Informatics University of Edinburgh United Kingdom a.p.smith-2@sms.ed.ac.uk Miles Osborne Division of Informatics model, then decoding using a logarithmic opinion pool (Smith et al., 2005), we may achieve much higher

Osborne, Miles

191

EIGENVALUES AND THE SMITH NORMAL FORM Joseph J. Rushanan  

E-print Network

EIGENVALUES AND THE SMITH NORMAL FORM Joseph J. Rushanan The MITRE Corporation, M/S E025, Bedford, MA 01730 Abstract. Results are shown that compare the Smith Normal Form (SNF) over the integers and its Smith Normal Form (SNF) over the integers. Our goals are more general than those results

Rushanan, Joe J.

192

Computation of Hermite and Smith Normal Forms of Matrices  

E-print Network

Computation of Hermite and Smith Normal Forms of Matrices by Arne Storjohann A thesis presented the problem of computing Hermite and Smith normal forms of ma­ trices over principal ideal domains. The main probabilistic algorithm to compute the Smith normal form of a polynomial matrix for those cases where pre

Storjohann, Arne

193

Smith & Telang/Competing with Free RESEARCH ARTICLE  

E-print Network

Smith & Telang/Competing with Free RESEARCH ARTICLE COMPETING WITH FREE: THE IMPACT OF MOVIE BROADCASTS ON DVD SALES AND INTERNET PIRACY 1 By: Michael D. Smith H. John Heinz III School of Public Policy. 321-338/June 2009 321 #12;Smith & Telang/Competing with Free Introduction "We can't compete with free

Sadeh, Norman M.

194

Extended Response to Weir and Smith Sven E. Wilson  

E-print Network

Extended Response to Weir and Smith Sven E. Wilson Brigham Young University Benjamin L. Howell University Phone: (801) 422-9018 Email: sven@byu.edu #12;2 Abstract Evidence provided by Weir and Smith and a variety of regression models (including that of Weir and Smith). In particular, our pooled regression

Martinez, Tony R.

195

Generating and Interpreting Referring Expressions in Dustin Arthur Smith  

E-print Network

Generating and Interpreting Referring Expressions in Context by Dustin Arthur Smith B.S., Wake Referring Expressions in Context by Dustin Arthur Smith Submitted to the Program of Media Arts and Sciences, MIT Media Lab #12;Generating and Interpreting Referring Expressions in Context by Dustin Arthur Smith

196

Immunological Memory is Associative Derek J. Smith  

E-print Network

Immunological Memory is Associative Derek J. Smith Department of Computer Science University of New Laboratory Los Alamos, NM 87545, USA asp@t10.lanl.gov Abstract This paper argues that immunological memory population in the immune system). Keywords: Immunological Memory, Associative Memory, Cross-Reactive Memory

Somayaji, Anil

197

Neonatal death in Marshall-Smith syndrome.  

PubMed

Marshall-Smith syndrome is characterized by accelerated skeletal maturation, failure to thrive and dysmorphic features. Since 1971, twenty cases of MSS have been reported. We describe another patient with a very early death demonstrating the clinical variability of the syndrome and the importance of systematic X rays of the skeleton for determining the causes of fetal or neonatal death. PMID:9555581

Chatel, C; Maazoul, F; Sigaudy, S; Fredouille, C; Ayme, S; Philip, N

1998-01-01

198

Genetic and evolutionary systems Robert E. Smith  

E-print Network

, and their use of operations that are inspired by natural genetic evolution. Most of the principles discussedGenetic and evolutionary systems Robert E. Smith The University of Alabama Department of Engineering Science and Mechanics Tuscaloosa, Alabama 35487 Abstract Genetic algorithms (GAs) are a class

Potter, Don

199

Updated 11/2013 Jimmy D. Smith  

E-print Network

as the Construction #12;Updated 11/2013 Manager for the first seven submarines of the VIRGINIA Class, Mr. Smith led, and in October 2004 the first submarine of the class - USS VIRGINIA (SSN 774) - was delivered to the U.S. Navy's newest class of ballistic missile submarines. In 2005, he served as the Director for Submarines

200

Dialogues with Marilyn Cochran-Smith  

ERIC Educational Resources Information Center

For more than 30 years, Dr. Marilyn Cochran-Smith has developed and directed research and contributed to publications about education and "practitioner research," especially about teachers' research and learning in inquiry communities. Her primary topics are inquiry communities, teacher research, teacher education for social…

Fiorentini, Dario; Crecci, Vanessa Moreira

2015-01-01

201

Nelson G. Hairston Frederick E. Smith  

E-print Network

Nelson G. Hairston Frederick E. Smith Lawrence B. Slobodkin Department of Zoology, The University Predators Competition Space #12;Nelson G. Hairston ~ Citation Classic "We cannot claim that a 5page paper. Nelson Hairston: http://en.wikipedia.org/wiki/Nelson_Hairston #12;

Jodice, Patrick

202

Another Perspective: An Interview with David Smith  

ERIC Educational Resources Information Center

To provide another perspective on evaluation within nonformal settings, "New Directions for Evaluation" recently interviewed David Smith, the coordinator of the Professional Learning to Close the Achievement Gap program for the Kansas City, Kansas, Public Schools, who has extensive background in education and educational research. He formerly held…

Bowman, Ruth A.; Johnson, Kelli

2005-01-01

203

Erika Smith, '08 Dar Es Salaam, Tanzania  

E-print Network

Erika Smith, '08 Dar Es Salaam, Tanzania This past summer I had the opportunity to spend six weeks volunteering in Dar es Salaam, Tanzania. Dar es Salaam is the largest city and until recently was the capital of Tanzania. As the first Siena/AMC student to spend their summer of service in Tanzania, I was apprehensive

204

Jason C Smith Department of Physical Oceanography  

E-print Network

Hole Oceanographic Institution Technical Report 2001-18, 57 pages Plueddemann, Ostrom, Galbraith, Smith Cruise Report". Woods Hole Oceanographic Institution Technical Report 2003-04, 73 pages Hutto, Weller and Deployment Cruise". Woods Hole Oceanographic Institution Technical Report 2005-06. 131 pages Hutto, Weller

Yu, Lisan

205

Adam Smith, Religion, and Tuition Tax Credits.  

ERIC Educational Resources Information Center

Examines tuition tax credit programs in framework of Adam Smith's ideas on the economic impact of established churches. Finds that tuition tax credits would amount to state expenditures to relieve the financial burden of parochial school parents and would allow churches to invest commercially to maintain their charitable functions. (JW)

Alexander, Kern

1983-01-01

206

Rodney K. Smith Award The Rodney K. Smith Award is the highest service award given by the Dean of The University of  

E-print Network

Rodney K. Smith Award The Rodney K. Smith Award is the highest service award given by the Dean of time in one year. Dean Kevin H. Smith explains, "Professor Rodney Smith was a colleague of mine.e., assisting with a visa application or preventing human trafficking). I believe Professor Smith would find

Dasgupta, Dipankar

207

Chromospheric Variability: Analysis of 36 years of Time Series from the National Solar Observatory/Sacramento Peak Ca II K-line Monitoring Program  

NASA Technical Reports Server (NTRS)

Analysis of more than 36 years of time series of seven parameters measured in the NSO/AFRL/Sac Peak K-line monitoring program elucidates five elucidates five components of the variation: (1) the solar cycle (period approx. 11 years), (2) quasi-periodic variations (periods approx 100 days), (3) a broad band stochastic process (wide range of periods), (4) rotational modulation, and (5) random observational errors. Correlation and power spectrum analyses elucidate periodic and aperiodic variation of the chromospheric parameters. Time-frequency analysis illuminates periodic and quasi periodic signals, details of frequency modulation due to differential rotation, and in particular elucidates the rather complex harmonic structure (1) and (2) at time scales in the range approx 0.1 - 10 years. These results using only full-disk data further suggest that similar analyses will be useful at detecting and characterizing differential rotation in stars from stellar light-curves such as those being produced by NASA's Kepler observatory. Component (3) consists of variations over a range of timescales, in the manner of a 1/f random noise process. A timedependent Wilson-Bappu effect appears to be present in the solar cycle variations (1), but not in the stochastic process (3). Component (4) characterizes differential rotation of the active regions, and (5) is of course not characteristic of solar variability, but the fact that the observational errors are quite small greatly facilitates the analysis of the other components. The recent data suggest that the current cycle is starting late and may be relatively weak. The data analyzed in this paper can be found at the National Solar Observatory web site http://nsosp.nso.edu/cak_mon/, or by file transfer protocol at ftp://ftp.nso.edu/idl/cak.parameters.

Scargle, Jeffrey D.; Keil, Stephen L.; Worden, Simon P.

2014-01-01

208

The Smith-Lemli-Opitz syndrome  

PubMed Central

The Smith-Lemli-Opitz syndrome (SLOS) is one of the archetypical multiple congenital malformation syndromes. The recent discovery of the biochemical cause of SLOS and the subsequent redefinition of SLOS as an inborn error of cholesterol metabolism have led to important new treatment possibilities for affected patients. Moreover, the recent recognition of the important role of cholesterol in vertebrate embryogenesis, especially with regard to the hedgehog embryonic signalling pathway and its effects on the expression of homeobox genes, has provided an explanation for the abnormal morphogenesis in the syndrome. The well known role of cholesterol in the formation of steroid hormones has also provided a possible explanation for the abnormal behavioural characteristics of SLOS.???Keywords: Smith-Lemli-Opitz syndrome; cholesterol metabolism; 7-dehydrocholesterol reductase; clinical history; management PMID:10807690

Kelley, R.; Hennekam, R.

2000-01-01

209

Roger E. Smith: 1986 Horton Award Recipient  

NASA Astrophysics Data System (ADS)

The recipient of the 1986 Robert T. Horton Award is Roger E. Smith. Roger received his bachelor's degree in civil engineering from Texas Technical University at Lubbock, Tex., in 1963, and his master's degree in civil engineering from Stanford University at Stanford, Calif., in 1964. Roger then spent 2 years in the Peace Corps Service in Pakistan. In 1967, he enrolled as a graduate student at Colorado State University.

Johnson, A. Ivan; Smith, Roger E.

210

Otorhinolaringologic manifestation of Smith–Magenis syndrome  

Microsoft Academic Search

Smith–Magenis syndrome (SMS) is a multiple congenital anomaly\\/mental retardation (MCA\\/MR) syndrome link to a contiguous-gene deletion syndrome, involving chromosome 1 7p 11.2,whose incidence is estimated to be 1:25?000 livebirth. SMS is characterised by a specific physical, behavioural and developmental pattern. The main clinical features consist of a broad flat midface with brachycefaly, broad nasal bridge, brachydactily, speech delay, hoarse deep

M Di Cicco; R Padoan; G Felisati; D Dilani; E Moretti; S Guerneri; A Selicorni

2001-01-01

211

The Smith Cloud: Galactic or Extragalactic?  

NASA Astrophysics Data System (ADS)

The Milky Way is surrounded by a population of gaseous high-velocity clouds (HVCs), which play an important role in bringing fresh fuel for star formation into the disk. The Smith Cloud is an HVC in an advanced state of accretion, only ~30 Myr away from impacting the Galactic plane. It is unique among HVCs in having a known distance (12.4 kpc) and a well-constrained 3D velocity (300 km/s), but we do not yet know its metallicity, which would distinguish between Galactic (metal-enriched) and extragalactic (metal-poor) origins. Here we propose a program to measure the Smith Cloud's metallicity using HST/COS spectra of three AGN lying behind the Cloud and its wake. Combining the UV metal-line (O I and S II) column densities with existing H I column densities will lead to precise abundance measurements for the Smith Cloud, directly constraining its origin. In addition, the relative strength of depleted (Fe II, Si II) to undepleted (S II) UV absorption lines will be used to infer its dust content. Finally, we will search for variation in the ionization level and kinematics between the three sight lines, which would indicate a disruptive encounter with the hot Galactic corona.

Fox, Andrew

2014-10-01

212

Antibody engineering and therapeutics conference. The annual meeting of the antibody society, Huntington Beach, CA, December 7-11, 2014.  

PubMed

The 25th anniversary of the Antibody Engineering & Therapeutics Conference, the Annual Meeting of The Antibody Society, will be held in Huntington Beach, CA, December 7-11, 2014. Organized by IBC Life Sciences, the event will celebrate past successes, educate participants on current activities and offer a vision of future progress in the field. Keynote addresses will be given by academic and industry experts Douglas Lauffenburger (Massachusetts Institute of Technology), Ira Pastan (National Cancer Institute), James Wells (University of California, San Francisco), Ian Tomlinson (GlaxoSmithKline) and Anthony Rees (Rees Consulting AB and Emeritus Professor, University of Bath). These speakers will provide updates of their work, placed in the context of the substantial growth of the industry over the past 25 years. PMID:25517297

Larrick, James W; Parren, Paul W H I; Huston, James S; Plückthun, Andreas; Bradbury, Andrew; Tomlinson, Ian M; Chester, Kerry A; Burton, Dennis R; Adams, Gregory P; Weiner, Louis M; Scott, Jamie K; Alfenito, Mark R; Veldman, Trudi; Reichert, Janice M

2014-01-01

213

Tropical spastic paraparesis treated with Combivir (lamivudine-zidovudine).  

PubMed

Tropical spastic paraparesis (TSP) or human T-cell leukemia virus-type 1 (HTLV-I)-associated myelopathy is caused by human T-lymphotropic virus type 1. It is a slow, progressive spastic paraparesis with significant morbidity and causing profound repercussions on quality of life. No therapies have been found to persistently improve the outcome in these patients. We present a patient with HTLV-1-associated myelopathy/TSP (HAM/TSP) who was treated with Combivir (lamivudine-zidovudine, GlaxoSmithKline, London, UK). She was walker-dependent for several years but, soon after treatment with lamivudine-zidovudine, was able to walk using only a cane. The role of lamivudine-zidovudine should be investigated further in this patient population. PMID:23477875

Hassan, Syed; Amer, Syed; Zervos, Marcus

2013-05-01

214

Pooled analysis of safety data from pediatric Phase II RTS,S/AS malaria candidate vaccine trials.  

PubMed

Prior to progression to Clinical Development Phase III, GlaxoSmithKline Biologicals performed a pooled analysis of phase two safety data following administration of 8860 doses of RTS,S/AS to 2981 children under 5 years old. RTS,S/AS was associated with increased rates of non-serious URTI, rash and diaper dermatitis graded mild or moderate. There was no significant increased rate of overall or single SAEs. Two episodes of simple febrile seizure were estimated to be related to vaccination. Significant decreased relative risks of death, any SAE, any SAE excluding malaria and pneumonia were observed. The results suggest a favourable risk-benefit balance which is to be confirmed in the ongoing Phase III trials. PMID:22108035

Vekemans, Johan; Guerra, Yolanda; Lievens, Marc; Benns, Sarah; Lapierre, Didier; Leach, Amanda; Verstraeten, Thomas

2011-12-01

215

Vaccines for the prevention of human papillomavirus infections.  

PubMed

Human papillomavirus (HPV) infection is the known cause of almost all cases of cervical cancer. An understanding of the HPV genome has allowed the development of two prophylactic vaccines capable of protecting against both persistent HPV infection and cervical intraepithelial neoplasia (CIN) with 100% efficacy in fully vaccinated women. The vaccines, manufactured by Merck (Gardasil, which was approved by the US FDA in June, 2006) and GlaxoSmithKline (Cervarix, which will be submitted for US FDA approval by the end of 2006), both target HPV types 16 and 18, which together account for 70% of cervical cancer. Merck vaccine also targets HPV 6 and 11, covering =90% of genital warts. These vaccines are highly immunogenic and have an excellent safety profile. HPV vaccines promise to offer an exciting contribution to healthcare and cancer prevention. However, many questions remain concerning who to vaccinate, the duration of protection, cost, public acceptance, and the potential for worldwide distribution. PMID:16912836

Speck, L M; Tyring, S K

2006-01-01

216

OOMMPPAA: a tool to aid directed synthesis by the combined analysis of activity and structural data.  

PubMed

There is an ever increasing resource in terms of both structural information and activity data for many protein targets. In this paper we describe OOMMPPAA, a novel computational tool designed to inform compound design by combining such data. OOMMPPAA uses 3D matched molecular pairs to generate 3D ligand conformations. It then identifies pharmacophoric transformations between pairs of compounds and associates them with their relevant activity changes. OOMMPPAA presents this data in an interactive application providing the user with a visual summary of important interaction regions in the context of the binding site. We present validation of the tool using openly available data for CDK2 and a GlaxoSmithKline data set for a SAM-dependent methyl-transferase. We demonstrate OOMMPPAA's application in optimizing both potency and cell permeability and use OOMMPPAA to highlight nuanced and cross-series SAR. OOMMPPAA is freely available to download at http://oommppaa.sgc.ox.ac.uk/OOMMPPAA/ . PMID:25244105

Bradley, Anthony R; Wall, Ian D; Green, Darren V S; Deane, Charlotte M; Marsden, Brian D

2014-10-27

217

Adam Smith and the Invisible Hand: From Metaphor to Myth  

Microsoft Academic Search

Adam Smith and the ‘invisible hand’ are nearly synonymous in modern economic thinking. Adam Smith is strongly associated with the invisible hand, understood as a general rule that people in realising their self-interests unintentionally benefit the public good. The attribution to Smith is challengeable. Adam Smith’s use of the metaphor was much more modest; it was re-invented in the 1930s

Gavin Kennedy

2009-01-01

218

Stimulated Smith-Purcell semiconductor THz sources  

NASA Astrophysics Data System (ADS)

We propose a novel room-temperature semiconductor source of narrowband coherent THz radiation that radiates via the Smith-Purcell effect and uses the Gunn effect to increase the radiated power (Figure 1). The radiation frequency of the device depends only on the grating period and the velocity of the Gunn domain, reaching low THz range with submicron grating. The Smith-Purcell effect is well-known in vacuum electronics and accelerator physics: a DC electron beam focused parallel to a metallic grating generates weak, incoherent electromagnetic radiation called spontaneous Smith-Purcell radiation (SPR). A bunched electron beam instead generates coherent stimulated SPR, with radiated power many orders of magnitude stronger than spontaneous SPR. Spontaneous SPR has been observed in semiconductors, but only at low temperature. The Gunn effect naturally provides space-charge bunching in semiconductors, and Gunn domains generate stimulated SPR at room temperature in the proposed devices. We develop a simple analytic model to describe the radiation which agrees well with device simulations. The small size of the radiative portion of the device suggests the use of an integrated antenna which significantly boosts the power of simulated devices. Our results indicate that the effect should be observable from a InP device, with power density of 30nW/?m of device width at 0.27 THz and 6nW/?m at 0.44THz. Results based on InN parameters look very promising for this approach with calculated power densities of 3.5?W/?m at 0.25THz, 20nW/?m at 1.0THz, and 3nW/?m at 2.0THz. We conclude that experimental investigation is warranted.

Smith, Don D.; Belyanin, Alexey

2011-02-01

219

Breeding productivity of Smith Island black ducks  

USGS Publications Warehouse

We investigated the breeding performance of American black ducks (Anas rubripes) on Smith Island, Chesapeake Bay, to improve our understanding of island black duck breeding ecology and to make management recommendations to enhance productivity. During 1995-96, we implanted 56 female black ducks with 20-g radio transmitters and tracked 35 of the individuals through the breeding season to locate nests, determine nest fate, and identify brood habitat. We also increased preseason banding efforts and compared capture characteristics over 12 years with those from the Deal Island Wildlife Management Area, a banding site on the mainland of Tangier Sound. A low rate of nesting (37%), lack of renesting, and poor hatching success (31%) indicated that island salt marsh habitats present a harsh environment for breeding black ducks. Black ducks located 11 of 13 nests (85%) in black needlerush (Juncus roemerianus) marsh where they were vulnerable to flooding from extreme tides and to egg predators. No nests were found on forested tree hammocks, a feature that distinguishes Smith Island from nearby South Marsh and Bloodsworth Islands. Nest predators included red foxes (Vulpes vulpes), herring gulls (Larus argentams), fish crows (Corvus ossifragus), and, potentially, Norway rats (Rattus norvegicus). Unlike mainland red foxes, foxes radio tracked on Smith Island were found to be capable swimmers and effective low marsh predators. We found shoreline meadows of widgeon grass (Ruppia maritima) to be important foraging sites for black ducks and suspected that the virtual absence of fresh water in this high salinity environment (1217+ ppt) to incur some cost in terms of growth and survival of ducklings. Preseason bandings revealed a high proportion of banded adults and a strong positive correlation in age ratios with the Deal Island banding site. This latter finding strongly suggests a negative universal effect of storm tides on nest success for Tangier Sound black ducks. Management to reduce nest predators, especially gulls and foxes, likely will have the greatest immediate benefit for island breeding black ducks.

Haramis, G.M.; Jorde, D.G.; Olsen, G.H.; Stotts, D.B.; Harrison, M.K.

2002-01-01

220

Trois bicentenaires : Hume, Condillac, Smith. Adam Smith entre le marginalisme et le marxisme  

Microsoft Academic Search

It is not easy to understand why, and how, orthodox economists who do not believe either in the labor-theory or in the cost-theory of value, continue to favor Adam Smith's Wealth of Nations, but forget such economists as Condillac, whose value theory is nearer to theirs and whose bicentenary we also commemorate.

Gérard R. Pelletier

1977-01-01

221

Smith Newton Vehicle Performance Evaluation - Cumulative (Brochure)  

SciTech Connect

The Fleet Test and Evaluation Team at the U.S. Department of Energy's National Renewable Energy Laboratory is evaluating and documenting the performance of electric and plug-in hybrid electric drive systems in medium-duty trucks across the nation. U.S. companies participating in this evaluation project received funding from the American Recovery and Reinvestment Act to cover part of the cost of purchasing these vehicles. Through this project, Smith Electric Vehicles is building and deploying 500 all-electric medium-duty trucks that will be deployed by a variety of companies in diverse climates across the country.

Not Available

2014-08-01

222

60% Review technical specifications, Deaf Smith Site  

SciTech Connect

The enclosed documentation for the 60% Review Technical Specifications, Deaf Smith Site includes: Solicitation Documents which represent the eventual Federal Acquisition Regulations (FARs) and Department of Energy Acquisition Regulations (DEARs) that will comprise a segment of the contractual documents for bidders attention; Contract Clauses that will become integral parts for the Fixed Price Construction Contracts applicable to the Exploratory Shaft Facility; Special Contract Requirements that will become contract provisions requiring specific contractor attention; Technical Specifications which have been completed for 60% submission, and the current list of 241 Contract Drawings that have been separately forwarded for review and comment.

Gast, R.A.

1987-08-01

223

Rodney K. Smith Award The Rodney K. Smith Award is the highest service award given by the Dean of the University of  

E-print Network

Rodney K. Smith Award The Rodney K. Smith Award is the highest service award given by the Dean. Humphreys School of Law, Rodney K. Smith's interest in, and respect for, public service was not limited trafficking). Interim Dean William P. Kratzke explains, "I knew Professor Rodney Smith when he was a faculty

Memphis, University of

224

40 CFR 81.63 - Metropolitan Fort Smith Interstate Air Quality Control Region.  

Code of Federal Regulations, 2011 CFR

...2011-07-01 false Metropolitan Fort Smith Interstate Air Quality Control Region...Regions § 81.63 Metropolitan Fort Smith Interstate Air Quality Control Region. The Metropolitan Fort Smith Interstate Air Quality Control...

2011-07-01

225

40 CFR 81.63 - Metropolitan Fort Smith Interstate Air Quality Control Region.  

Code of Federal Regulations, 2013 CFR

...2013-07-01 false Metropolitan Fort Smith Interstate Air Quality Control Region...Regions § 81.63 Metropolitan Fort Smith Interstate Air Quality Control Region. The Metropolitan Fort Smith Interstate Air Quality Control...

2013-07-01

226

40 CFR 81.63 - Metropolitan Fort Smith Interstate Air Quality Control Region.  

Code of Federal Regulations, 2014 CFR

...2014-07-01 false Metropolitan Fort Smith Interstate Air Quality Control Region...Regions § 81.63 Metropolitan Fort Smith Interstate Air Quality Control Region. The Metropolitan Fort Smith Interstate Air Quality Control...

2014-07-01

227

40 CFR 81.63 - Metropolitan Fort Smith Interstate Air Quality Control Region.  

Code of Federal Regulations, 2012 CFR

...2012-07-01 false Metropolitan Fort Smith Interstate Air Quality Control Region...Regions § 81.63 Metropolitan Fort Smith Interstate Air Quality Control Region. The Metropolitan Fort Smith Interstate Air Quality Control...

2012-07-01

228

40 CFR 81.63 - Metropolitan Fort Smith Interstate Air Quality Control Region.  

Code of Federal Regulations, 2010 CFR

...2010-07-01 false Metropolitan Fort Smith Interstate Air Quality Control Region...Regions § 81.63 Metropolitan Fort Smith Interstate Air Quality Control Region. The Metropolitan Fort Smith Interstate Air Quality Control...

2010-07-01

229

78 FR 23845 - Drawbridge Operation Regulations; Narrow Bay, Smith Point, NY  

Federal Register 2010, 2011, 2012, 2013, 2014

...Drawbridge Operation Regulations; Narrow Bay, Smith Point, NY AGENCY: Coast Guard, DHS...regulation governing the operation of the Smith Point Bridge, mile 6.1, across Narrow Bay, between Smith Point and Fire Island, New York. The...

2013-04-23

230

76 FR 60733 - Drawbridge Operation Regulations; Narrow Bay, Smith Point, NY  

Federal Register 2010, 2011, 2012, 2013, 2014

...Drawbridge Operation Regulations; Narrow Bay, Smith Point, NY AGENCY: Coast Guard, DHS. ACTION...regulation governing the operation of the Smith Point Bridge, 6.1, across Narrow Bay, between Smith Point and Fire Island, New York. The...

2011-09-30

231

Author! Author! The Gallant Children's Author: Dick King-Smith  

ERIC Educational Resources Information Center

This column presents a brief biography of Dick King-Smith. Born on March 27, 1922 and raised in Gloucestershire, England, he grew up with animals of all kinds. King-Smith was a farmer for twenty years and then became a school teacher. He was also a soldier during wartime, a traveling salesman, shoe factory worker, and television presenter. He…

Brodie, Carolyn S.

2005-01-01

232

Evolutionary Ecology Research, 2001, 3: 331344 2001 Adam R. Smith  

E-print Network

Evolutionary Ecology Research, 2001, 3: 331­344 © 2001 Adam R. Smith Correlated evolution of colony defence and social structure: A comparative analysis in eusocial wasps (Hymenoptera: Vespidae) Adam R. Smith,1 * Sean O'Donnell1 and Robert L. Jeanne2 1 Animal Behavior Area, Department of Psychology

O'Donnell, Sean

233

Smith-Lemli-Opitz Syndrome: A Case with Annular Pancreas  

PubMed Central

Smith-Lemli-Opitz syndrome is an autosomal recessive disease of cholesterol metabolism. It is a multiple malformation syndrome with typical dysmorphic features such as bitemporal narrowing, ptosis, epicanthus, microcephaly, micrognathia, and cardiovascular, skeletal, urogenital, and gastrointestinal anomalies. This report presents a typical case of Smith-Lemli-Opitz syndrome with annular pancreas which is an unreported gastrointestinal abnormality. PMID:25165593

Demirdöven, Mehmet; Yazgan, Hamza; Korkmaz, Mevlit; Gebe?çe, Arzu; Tonbul, Alparslan

2014-01-01

234

Improved amino acid flexibility parameters DAVID K. SMITH,1  

E-print Network

Improved amino acid flexibility parameters DAVID K. SMITH,1 PREDRAG RADIVOJAC,2 ZORAN OBRADOVIC,2 A or even global disorder for the proper functioning of a protein (Wright and Dyson 1999; Bright et al. 2001 (Karplus and Schulz 1985; Vihinen et al. Reprint requests to: David K. Smith, Biochemistry Department

Obradovic, Zoran

235

1. VIEW OF THE SMITH NO. 3 SITE AREA TO ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. VIEW OF THE SMITH NO. 3 SITE AREA TO THE NORTHWEST. THE MINE OFFICE BUILDING IS IN THE FOREGROUND AND THE TIPPLE AND PROCESSING PLANT ARE IN THE BACKGROUND. - Smith Mine, Bear Creek 1.5 miles West of Town of Bear Creek, Red Lodge, Carbon County, MT

236

College of Agricultural Sciences Calvin & Merle Smith Wheat Research  

E-print Network

College of Agricultural Sciences Calvin & Merle Smith Wheat Research Endowment Fund Application PURPOSE The Calvin & Merle Smith Wheat Research Endowment Fund supports a student's work on an OSU wheat of Agricultural Sciences and related fields who are working on OSU wheat research projects. Funds may be used

Grünwald, Niklaus J.

237

(Mis)Representing Underachievement: A Rejoinder to Gorard and Smith  

ERIC Educational Resources Information Center

This article provides a brief rejoinder to Gorard and Smith's reply to an article I published in a previous issue of British Journal of Sociology of Education. In that original article I provided a critical review of their quantitative research on gender and education in the United Kingdom. In their reply to this article, Gorard and Smith seem to…

Connolly, Paul

2008-01-01

238

Father Knows Best: Using Adam Smith to Teach Transactions Costs  

ERIC Educational Resources Information Center

Adam Smith's moral philosophy can be used to introduce economics students to the important idea of transactions costs. The author provides a brief background in this article to Smith's moral philosophy and connects it to the costs of transacting in a way that fits easily into the standard principles of microeconomics classroom. By doing…

Dupont, Brandon

2014-01-01

239

Oscar F. Smith Middle School: One Extra Degree  

ERIC Educational Resources Information Center

This article features Oscar F. Smith Middle School, a challenging school in Chesapeake, Virginia. When Principal Linda Scott exclaims, "Oscar F. Smith Middle School is "hot"!" to visitors, she is not referring to the inside temperature of the bustling school of grades 6-8 located in the historic South Norfolk borough of Chesapeake. She is…

Principal Leadership, 2012

2012-01-01

240

DIVINE ACTION, PROVIDENCE AND ADAM SMITH'S INVISIBLE HAND  

Microsoft Academic Search

Recent sustained attention the background of Adam Smith's invisible hand has not resolved its meaning. In particular the status of the older dominant interpretation that the hand is God's remains unclear. This paper argues that a more nuanced understanding of divine action, drawing on Isaac Newton's understanding of special and general providence is the key to understanding Smith's invisible hand.

Paul Oslington

241

An anatomy of authority: Adam Smith as political theorist  

Microsoft Academic Search

Authority for Smith arises ironically from the desire to attain a high station in life. Given that most people fail, they 'free ride': they identify their ego with high-ranking agents, through 'vicarious sympathy'. Vicarious sympathy gives rise to status and, if combined with utility, would occasion political allegiance, the basis of political order (an invisible hand argument). Smith's theory challenges

Elias L. Khalil

2005-01-01

242

Environmental assessment overview, Deaf Smith County site, Texas  

SciTech Connect

In February 1983, the US Department of Energy (DOE) identified a location in Deaf Smith County, Texas, as one of nine potentially acceptable sites for mined geologic repository for spent nuclear fuel and high-level radioactive waste. To determine their suitability, the Deaf Smith County site and eight other potentially acceptable sites have been evaluated in accordance with the DOE's General Guidelines for the Recommendation of Sites for the Nuclear Waste Repositories. The Deaf Smith County site is in the Permian Basin, which is one of five distinct geohydrologic settings considered for the first repository. On the basis of the evaluations reported in this EA, the DOE has found that the Deaf Smith County site is not disqualified under the guidelines. On the basis of these findings, the DOE is nominating the Deaf Smith County site as one of five sites suitable for characterization. 3 figs.

Not Available

1986-05-01

243

The rise of China: Marx's solution or Adam Smith's? On China's rise in Adam Smith in Beijing by Giovanni Arrighi  

Microsoft Academic Search

Adam Smith in Beijing offers a subversive analysis of China's rise, an analysis which has provoked a strong reaction in the academic world outside China. Based on Adam Smith's economic principles and world systems analysis, the book comprehensively explores China's reform and opening up and its market economy, as well as the role they have played in China's rise. In

Wu Yuanhua

2011-01-01

244

Dental development of the Ta Forest chimpanzees revisited T.M. Smith a,b,*, B.H. Smith c  

E-print Network

Dental development of the Taï Forest chimpanzees revisited T.M. Smith a,b,*, B.H. Smith c , D Biology, School of Dental Sciences, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4BW an emerging mandibular M1 at death (previously estimated from the maxillary molar as occurring at 4.1 years

245

Trinucleotide repeat expansion and DRPLA (Smith`s disease): Molecular characterization of atrophin-1  

SciTech Connect

Smith`s disease (also known as dentatorubral pallidoluysian atrophy or DRPLA) is a rare, progressive, fatal neuropsychiatric disorder similar to Huntington`s disease (HD). Smith`s disease is characterized by ataxia, choreoathetosis, myoclonic epilepsy, dementia, and genetic anticipation. Neuropathological findings include prominent cell loss in the dentate nucleus of the cerebellum, the globus pallidus, the red nucleus, and the subthalamic nucleus. An expansion of a CAG trinucleotide repeat encoding polyglutamine in a gene originally identified in our laboratory as part of a program to clone candidate genes for disorders with anticipation has recently been found to cause this disorder. We have identified two families that demonstrate the pathological and genetic features (expanded CAG repeat and anticipation) of this disease. Northern analysis indicates that the gene, which we have termed atrophin-1, is widely expressed as a 5 kb mRNA in normal human brain and peripheral tissues. Brain expression is highest in the cerebellum. The developmental expression of the rat homologues of IT-15 (the gene in which a CAG expansion causes HD) and atrophin-1 were compared. Atrophin-1 was most highly expressed in early rat embryo brain (E16), whereas the greatest expression of IT-15 was in the adult rat brain. Cloning and sequencing of the open reading frame from inserts contained in brain cDNA libraries is in progress. In addition to the CAG repeat, the ORF contains an unusual region of alternating acidic and basic amino acids. Further characterization of atrophin-1, and comparison of it to other genes in which trinucleotide repeat expansion leads to neuropsychiatric disorders, should lead to a better understanding of the pathophysiology by which CAG repeat expansion causes human disease.

Margolis, R.L.; Li, S.H.; Li, X.J.; Ross, C.A. [Johns Hopkins Univ., Balitmore, MD (United States)

1994-09-01

246

Sophia Smith Collection: Voices of Feminism  

NSDL National Science Digital Library

Based at Smith College, the Voices of Feminism Oral History Project "documents the persistence and diversity of organizing for women in the United States in the latter half of the 20th century." The women interviewed here include labor, peace, and anti-racism activists, along with anti-poverty organizers and lesbian rights advocates. The project was funded by the Ford Foundation from 2002 to 2008, and visitors will find that they can also read transcripts of the interviews as well. The "Narrators" page features biographical profiles of each interviewee, along with links to the transcript of each interview. As a bonus feature, there are video excerpts for six of the women interviewed as part of the project.

247

THE ROSENZWEIG-MACARTHUR PREDATOR-PREY HAL L. SMITH*  

E-print Network

THE ROSENZWEIG-MACARTHUR PREDATOR-PREY MODEL HAL L. SMITH* SCHOOL OF MATHEMATICAL AND STATISTICAL. It is the per predator kill rate. 1 #12;2 H.L. Smith 0 0.5 1 1.5 2 2.5 3 3.5 0 0.2 0.4 0.6 0.8 1 1.2 1.4 1.6 1 that solutions are bounded in the future and therefore are defined for all t 0. #12;4 H.L. Smith Notice that 2

Smith, Hal

248

STS-82 Mission Specialist Steven L. Smith Suit Up  

NASA Technical Reports Server (NTRS)

STS-82 Mission Specialist Steven L. Smith gives a ''';thumbs up'''; while donning his launch and entry suit in the Operations and Checkout Building. A suit technician stands ready to assist with final adjustments. This is Smith''';s second space flight. He and the six other crew members will depart shortly for Launch Pad 39A, where the Space Shuttle Discovery awaits liftoff on a 10-day mission to service the orbiting Hubble Space Telescope (HST). This will be the second HST servicing mission. Four back-to-back spacewalks are planned.

1997-01-01

249

Robert William Smith: His Life and His Contributions to Medicine  

PubMed Central

Robert William Smith is best known for his contribution to Smith’s fracture. He also made other significant contributions to medicine and medical education, publishing on topics ranging from arthritis to neuroma. He had a great interest in pathology and helped found the Pathological Society of Dublin. At the time of his death, he was the Vice President of the Royal College of Surgeons in Ireland. His contributions to the understanding of various pathological conditions make him an important figure in medicine and in hand surgery. PMID:18656770

Shah, Hriday M.; Chung, Kevin C.

2015-01-01

250

Laurie Brban and Andr Lapidus Adam Smith on Lotteries 01.12.2013 13:42  

E-print Network

Laurie Bréban and André Lapidus ­ Adam Smith on Lotteries 01.12.2013 13:42 1 ADAM SMITH The few pages that Adam Smith devoted to lotteries, mainly in the Wealth of Nations (1776) did not receive transformed into risk-aversion. Keywords: Adam Smith, decision, risk, lotteries, stochastic dominance, rank

Paris-Sud XI, Université de

251

Julius Smith LAC-2008 1 / 66 Virtual Electric Guitars and Effects Using Faust and Octave  

E-print Network

Julius Smith LAC-2008 ­ 1 / 66 Virtual Electric Guitars and Effects Using Faust and Octave Julius Smith CCRMA, Stanford University LAC-2008 March 1, 2008 #12;Outline Julius Smith LAC-2008 ­ 2 / 66 Smith LAC-2008 ­ 3 / 66 (Extended Karplus Strong, Sullivan extensions, early waveguide) · Some patents

Smith III, Julius Orion

252

Collective Trust and Normative Agents Clara Smith1 and Antonino Rotolo2  

E-print Network

Collective Trust and Normative Agents Clara Smith1 and Antonino Rotolo2 1Facultad de Inform ESTRELLA (IST-2004-027655). C. Smith and A. Rotolo Collective Trust ­ NormMAS 2008 #12;Layout C. Smith. C. Smith and A. Rotolo Collective Trust ­ NormMAS 2008 #12;Layout Collective trust: Why? Three

van der Torre, Leon

253

Single shot longitudinal profile monitors using Coherent Smith-Purcell radiation  

E-print Network

Single shot longitudinal profile monitors using Coherent Smith-Purcell radiation H.L. Andrewsd , F Coherent Smith-Purcell radiation has the potential of providing information on the longitudinal profile an accurate 2D map of the Coherent Smith- Purcell Radiation emission. Keywords: Coherent Smith Purcell

Paris-Sud XI, Université de

254

Brian Smith Memorial Entrance Scholarship This Scholarship is not currently open for  

E-print Network

Brian Smith Memorial Entrance Scholarship This Scholarship is not currently open for applications update scholarships@waikato.ac.nz for other funding opportunities. #12;Brian Smith Memorial Entrance Scholarship REGULATIONS FOR THE BRIAN SMITH MEMORIAL ENTRANCE SCHOLARSHIP BACKGROUND The Brian Smith Memorial

Waikato, University of

255

The Compositional Evolution of the Murid Genome Nick G.C. Smith,1  

E-print Network

The Compositional Evolution of the Murid Genome Nick G.C. Smith,1 Adam Eyre-Walker2 1 Department-Walker 1999; Smith and Eyre- Walker 2001). Given that the GC content of protein- coding genes is highly polymorphism data fromCorrespondence to: Nick Smith; email: nick.smith@ebc.uu.se J Mol Evol (2002) 55

Eyre-Walker, Adam

256

DETAIL OF WESTINGHOUSE AND B. MORGAN SMITH NAMEPLATES ON ELECTRIC ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

DETAIL OF WESTINGHOUSE AND B. MORGAN SMITH NAMEPLATES ON ELECTRIC GENERATOR IN UPPER LEVEL OF HYDROELECTRIC POWER HOUSE - St. Lucie Canal, Lock No. 1, Hydroelectric Power House, St. Lucie, Cross State Canal, Okeechobee Intracoastal Waterway, Stuart, Martin County, FL

257

Modeling and Reasoning about Everyday Events Dustin Arthur Smith  

E-print Network

Modeling and Reasoning about Everyday Events Dustin Arthur Smith Thesis Proposal for the Degree SIGNED: THESIS READER: Erik T. Mueller Research Staff Member IBM Thomas J. Watson Research Center SIGNED

Herr, Hugh

258

MORTALITY ESTIMATES FROM SIZE DISTRIBUTIONS: A CRITIQUE OF SMITH'S MODEL  

EPA Science Inventory

Smith (1972) described a method of computing mortality rates from growth and size-frequency data for a population which meets several assumptions. (Copyright (c) 1977 by The American Society of Limnology and Oceanography, Inc.)...

259

STS-82 M.S. Steven Smith in White Room  

NASA Technical Reports Server (NTRS)

STS-82 Mission Specialist Steven L. Smith prepares to enter the Space Shuttle Discovery at Launch Pad 39A, with the assistance of white room closeout crew members Dave Law, in front; Carlous Gillis, at left; and James Davis.

1997-01-01

260

Longitudinal profile monitors using Coherent Smith-Purcell radiation  

NASA Astrophysics Data System (ADS)

Coherent Smith-Purcell radiation has the potential of providing information on the longitudinal profile of an electron bunch. The E-203 experiment at the FACET User Facility measures bunch profiles from the SLAC linac in the hundreds of femtoseconds range and the SPESO collaboration at Synchrotron SOLEIL is planning to make an accurate 2D map of the Coherent Smith-Purcell Radiation emission.

Andrews, H. L.; Bakkali Taheri, F.; Barros, J.; Bartolini, R.; Cassinari, L.; Clarke, C.; Le Corre, S.; Delerue, N.; Doucas, G.; Fuster-Martinez, N.; Konoplev, I.; Labat, M.; Perry, C.; Reichold, A.; Stevenson, S.; Vieille Grosjean, M.

2014-03-01

261

INNER FUNCTIONS IN THE HYPERBOLIC LITTLE BLOCH CLASS Wayne Smith  

E-print Network

INNER FUNCTIONS IN THE HYPERBOLIC LITTLE BLOCH CLASS Wayne Smith Abstract. An analytic function. Typeset by AMS-TEX 1 #12;2 WAYNE SMITH It is easy to see that C : B B is bounded for every analytic self-map of D, while C : B0 B0 is bounded if and only if B0. It is a recent result of K. Madigan and A

Smith, Wayne

262

STS-82 Mission Specialist Steven L. Smith during TCDT  

NASA Technical Reports Server (NTRS)

STS-82 Mission Specialist Steven L. Smith adjusts the glove of his launch and entry space suit during a practice countdown at KSC. Smith and the other six STS-82 crew members are at KSC to participate in the Terminal Countdown Demonstration Test (TCDT), a dress rehearsal for launch. STS-82 will be the second Hubble Space Telescope servicing mission. Liftoff is targeted for February 11.

1997-01-01

263

Kiki Smith: Prints, Books & Things at MoMA  

NSDL National Science Digital Library

Using a similar interface to that of Artists of Brücke (German Expressionist prints, reviewed in the December 5, 2003 and Nov.2, 2001 Scout Reports), the Museum of Modern Art (MoMA) presents this major retrospective of the work of Kiki Smith, born in 1954 in Nuremberg, Germany. Smith is the daughter of American sculptor Tony Smith, and her first experience with art was helping her father make cardboard models for his geometric sculptures. She is thought of as a sculptor and builder of installations, but since the 1980s, has created an extensive body of printed works, 135 of which are gathered in this web exhibition. Like the Expressionist show, the Smith show features a virtual light table of images that can be arranged dynamically by Themes -- early screen prints, anatomy, self-portraits, nature, feminine contexts -- or Mediums. In recent years, Smith has worked on etchings pulled from plates of monumental size, roughly 4 feet by 6 feet, such as a series based on Lewis Carroll, including Pool of Tears 2 (2000) and Come Away from Her (2003). The site also includes a chronology of Smith's life and a 35-page essay by Wendy Weitman, MoMA's Curator of Prints and illustrated Books.

264

MAGNETIZED GAS IN THE SMITH HIGH VELOCITY CLOUD  

SciTech Connect

We report the first detection of magnetic fields associated with the Smith High Velocity Cloud. We use a catalog of Faraday rotation measures toward extragalactic radio sources behind the Smith Cloud, new H I observations from the Robert C. Byrd Green Bank Telescope, and a spectroscopic map of H? from the Wisconsin H-Alpha Mapper Northern Sky Survey. There are enhancements in rotation measure (RM) of ?100 rad m{sup –2} which are generally well correlated with decelerated H? emission. We estimate a lower limit on the line-of-sight component of the field of ?8 ?G along a decelerated filament; this is a lower limit due to our assumptions about the geometry. No RM excess is evident in sightlines dominated by H I or H? at the velocity of the Smith Cloud. The smooth H? morphology of the emission at the Smith Cloud velocity suggests photoionization by the Galactic ionizing radiation field as the dominant ionization mechanism, while the filamentary morphology and high (?1 Rayleigh) H? intensity of the lower-velocity magnetized ionized gas suggests an ionization process associated with shocks due to interaction with the Galactic interstellar medium. The presence of the magnetic field may contribute to the survival of high velocity clouds like the Smith Cloud as they move from the Galactic halo to the disk. We expect these data to provide a test for magnetohydrodynamic simulations of infalling gas.

Hill, Alex S.; McClure-Griffiths, Naomi M. [CSIRO Astronomy and Space Science, Marsfield, NSW (Australia); Mao, S. A. [Department of Astronomy, University of Wisconsin-Madison, Madison, WI (United States); Benjamin, Robert A. [Department of Physics, University of Wisconsin-Whitewater, Whitewater, WI (United States); Lockman, Felix J., E-mail: alex.hill@csiro.au, E-mail: naomi.mcclure-griffiths@csiro.au, E-mail: mao@astro.wisc.edu, E-mail: benjamir@uww.edu, E-mail: jlockman@nrao.edu [National Radio Astronomy Observatory, Green Bank, WV (United States)

2013-11-01

265

Smith-Petersen and early development of hip arthroplasty.  

PubMed

Dr. Marius N. Smith-Petersen, in Boston, MA, USA, introduced the mould arthroplasty (1923). He used a reactive synovial-like membrane that he found had developed around a piece of glass he had removed from a workman's back, which had been imbedded there for a year. The original design was a ball-shaped, hollow hemisphere of glass that could fit over the femoral head of the hip joint. The objective was to stimulate cartilage regeneration on both sides of the moulded glass joint. Smith-Peterson intended to remove the glass after the cartilage had been restored. Glass provided a new, smooth surface for movement, and although proving biocompatible, it could not withstand the stresses of walking and quickly failed. Smith-Petersen succeeded in his endeavour by using Vitallium alloy. PMID:24173675

Hernigou, Philippe

2014-01-01

266

SR-71 Pilot Rogers E. Smith  

NASA Technical Reports Server (NTRS)

Research pilot Rogers E. Smith is shown here in front of the SR-71 Blackbird he flew for NASA. Rogers was one of the two original NASA research pilots assigned to the SR-71 high speed research program at NASA's Ames-Dryden Flight Research Facility (later, Dryden Flight Research Center, Edwards, California. Smith has been a NASA research pilot at Dryden since 1982. Data from the SR-71 program will be used to aid designers of future supersonic aircraft and propulsion systems. The SR-71 is capable of flying more than 2200 mph (Mach 3+) and at altitudes of over 80,000 feet. Two SR-71 aircraft have been used by NASA as testbeds for high-speed and high-altitude aeronautical research. The aircraft, an SR-71A and an SR-71B pilot trainer aircraft, have been based here at NASA's Dryden Flight Research Center, Edwards, California. They were transferred to NASA after the U.S. Air Force program was cancelled. As research platforms, the aircraft can cruise at Mach 3 for more than one hour. For thermal experiments, this can produce heat soak temperatures of over 600 degrees Fahrenheit (F). This operating environment makes these aircraft excellent platforms to carry out research and experiments in a variety of areas -- aerodynamics, propulsion, structures, thermal protection materials, high-speed and high-temperature instrumentation, atmospheric studies, and sonic boom characterization. The SR-71 was used in a program to study ways of reducing sonic booms or over pressures that are heard on the ground, much like sharp thunderclaps, when an aircraft exceeds the speed of sound. Data from this Sonic Boom Mitigation Study could eventually lead to aircraft designs that would reduce the 'peak' overpressures of sonic booms and minimize the startling affect they produce on the ground. One of the first major experiments to be flown in the NASA SR-71 program was a laser air data collection system. It used laser light instead of air pressure to produce airspeed and attitude reference data, such as angle of attack and sideslip, which are normally obtained with small tubes and vanes extending into the airstream. One of Dryden's SR-71s was used for the Linear Aerospike Rocket Engine, or LASRE Experiment. Another earlier project consisted of a series of flights using the SR-71 as a science camera platform for NASA's Jet Propulsion Laboratory in Pasadena, California. An upward-looking ultraviolet video camera placed in the SR-71's nosebay studied a variety of celestial objects in wavelengths that are blocked to ground-based astronomers. Earlier in its history, Dryden had a decade of past experience at sustained speeds above Mach 3. Two YF-12A aircraft and an SR-71 designated as a YF-12C were flown at the center between December 1969 and November 1979 in a joint NASA/USAF program to learn more about the capabilities and limitations of high-speed, high-altitude flight. The YF-12As were prototypes of a planned interceptor aircraft based on a design that later evolved into the SR-71 reconnaissance aircraft. Dave Lux was the NASA SR-71 project manger for much of the decade of the 1990s, followed by Steve Schmidt. Developed for the USAF as reconnaissance aircraft more than 30 years ago, SR-71s are still the world's fastest and highest-flying production aircraft. The aircraft can fly at speeds of more than 2,200 miles per hour (Mach 3+, or more than three times the speed of sound) and at altitudes of over 85,000 feet. The Lockheed Skunk Works (now Lockheed Martin) built the original SR-71 aircraft. Each aircraft is 107.4 feet long, has a wingspan of 55.6 feet, and is 18.5 feet high (from the ground to the top of the rudders, when parked). Gross takeoff weight is about 140,000 pounds, including a possible fuel weight of 80,280 pounds. The airframes are built almost entirely of titanium and titanium alloys to withstand heat generated by sustained Mach 3 flight. Aerodynamic control surfaces consist of all-moving vertical tail surfaces, ailerons on the outer wings, and elevators on the trailing edges between the engine exhaust nozzles. The two SR-71s at Dryden ha

1992-01-01

267

75 FR 41922 - Notice of Intent To Rule on Request To Release Airport Property at Fort Smith Regional Airport...  

Federal Register 2010, 2011, 2012, 2013, 2014

...Rule on Request To Release Airport Property at Fort Smith Regional Airport, Fort Smith, AR AGENCY: Federal Aviation Administration...invites public comment on the release of land at Fort Smith Regional Airport under the provisions of Title...

2010-07-19

268

78 FR 31988 - Atomic Safety and Licensing Board; In the Matter of Charlissa C. Smith (Denial of Senior Reactor...  

Federal Register 2010, 2011, 2012, 2013, 2014

...Board; In the Matter of Charlissa C. Smith (Denial of Senior Reactor Operator License...2013, Order granting Ms. Charlissa Smith's demand for hearing. LBP-13-03...2013). This hearing will consider Ms. Smith's arguments related to her...

2013-05-28

269

77 FR 34337 - Uinta-Wasatch-Cache National Forest; Evanston-Mountain View Ranger District; Utah; Smiths Fork...  

Federal Register 2010, 2011, 2012, 2013, 2014

...Evanston-Mountain View Ranger District; Utah; Smiths Fork Vegetation Restoration Project AGENCY...correction to the notice of intent for the Smiths Fork Vegetation Restoration Project published...DATES: The scoping period for the Smiths Fork Vegetation Restoration Project...

2012-06-11

270

Visible violence in Kiki Smith's Life wants to live.  

PubMed

Recent theoretical analyses of domestic violence have posited the complicity of medical communities in erasing and obfuscating the cause of injuries. Although medical cultures have engaged in progressive initiatives to address and treat domestic violence, these medical and clinical models can render domestic violence invisible by framing the battered woman as evidentiary object. By analyzing this invisibility of domestic violence through the concept of public secrecy, in this article I consider Kiki Smith's 1982 installation piece Life Wants to Live. Using medical technologies, Smith's installation offers the viewer a vision of domestic violence that recognizes its inherently problematic invisibility and emphasizes the importance of lived, bodily experience. PMID:15055387

Coulthard, Lisa

2004-01-01

271

Description of floodplains and wetlands, Deaf Smith County site, Texas  

SciTech Connect

Floodplains and wetlands are important features of the Texas Panhandle landscape, and are found on the Deaf Smith County site and in its vicinity. Use or disturbance of floodplains and wetlands in relation to the Civilian Radioactive Waste Management Program is subject to environmental review requirements implementing two Executive Orders. This report provides general information on playa wetlands in the Texas Panhandle, and describes and maps floodplains and wetlands on the Deaf Smith site and in its vicinity. The report is based on the published literature, with information from limited field reconnaissance included.

Not Available

1986-11-01

272

77 FR 58181 - Power Resources, Inc., Smith Ranch Highland Uranium Project; License Renewal Request, Opportunity...  

Federal Register 2010, 2011, 2012, 2013, 2014

...Resources, Inc., Smith Ranch Highland Uranium Project; License Renewal Request, Opportunity...referenced. The Smith Ranch Highland Uranium Project license renewal request is available...Mandeville, Senior Project Manager, Uranium Recovery Licensing Branch, Division...

2012-09-19

273

75 FR 9441 - Lucas-Smith Automotive, Inc.: Potosi, MO; Notice of Negative Determination Regarding Application...  

Federal Register 2010, 2011, 2012, 2013, 2014

...Employment and Training Administration [TA-W-71,388] Lucas-Smith Automotive, Inc.: Potosi, MO; Notice of Negative Determination...TAA), applicable to workers and former workers of Lucas- Smith Automotive, Inc., Potosi, Missouri (subject firm)....

2010-03-02

274

Dynamic molecular recognition on the surface of vesicle membranes{ Hua Jiang and Bradley D. Smith*  

E-print Network

Dynamic molecular recognition on the surface of vesicle membranes{ Hua Jiang and Bradley D. Smith-mail: smith.115@nd.edu; Fax: 1 574 631 6652; Tel: 1 574 631 8632 { Electronic supplementary information (ESI

Smith, Bradley D.

275

The Robert H. Smith Faculty of Agriculture, Food & Environment The Division for External Studies  

E-print Network

The Robert H. Smith Faculty of Agriculture, Food & Environment The Division for External Studies to the age of 35, for a one or two year master's degree at the Robert H. Smith Faculty of Agriculture, Food

Anat, Maril,

276

COUNTY REVENUE GENERATION HANDBOOK Smith Lever Act and Fees for Service  

E-print Network

COUNTY REVENUE GENERATION HANDBOOK Smith Lever Act and Fees for Service The current USDA user fees is inconsistent with the statutorypurposes ofthe Smith-Lever Act. Therefore,user fees may not be charged

Collins, Gary S.

277

Adam Smith School of Business Management Ltd GUIDE TO INFORMATION AVAILABLE THROUGH OUR PUBLICATION SCHEME  

E-print Network

Adam Smith School of Business Management Ltd GUIDE TO INFORMATION AVAILABLE THROUGH OUR PUBLICATION and what it might cost. Adam Smith School of Business Management Ltd is wholly publicly owned Where Adam Smith School of Business Management Ltd holds the copyright in its published information

Glasgow, University of

278

Local Reasoning about Mashups Philippa Gardner, Gareth Smith, and Adam Wright  

E-print Network

Local Reasoning about Mashups Philippa Gardner, Gareth Smith, and Adam Wright Imperial College homepage Lorem ipsum dolor sit amet, Updates Testing.. Adam Wright Proving... Gareth Smith updates... Adam Wright Proving... Gareth Smith Twitter twitter.example.com Web Browser Fig. 1. Twitter mashup

Gardner, Philippa

279

EventMinder: A Personal Calendar Assistant That Understands Dustin Arthur Smith  

E-print Network

EventMinder: A Personal Calendar Assistant That Understands Events by Dustin Arthur Smith Bachelor Events by Dustin Arthur Smith Submitted to the Program in Media Arts and Sciences, School of Architecture Dustin Arthur Smith The following people served as readers for this thesis: Thesis Reader Marvin Minsky

Herr, Hugh

280

Networked control systems based on generalized predictive control and modified Smith predictor  

Microsoft Academic Search

The distributed control networks encounter nondeterministic delays in data communication between sensors, actuators and controllers, including direct-feedback control and higher level supervisor control. Aiming to uncertain network delays, time-variant or nonlinear controlled plant and imprecise Smith predictor models, a novel approach is proposed that modified Smith predictor combined with generalized predictive control (GPC). Because modified Smith predictor does not include

Du Feng; Qian Qingquan

2008-01-01

281

Integer Smith Form via the Valence: Experience with Large Sparse Matrices from Homology 1  

E-print Network

Integer Smith Form via the Valence: Experience with Large Sparse Matrices from Homology 1 J.Villard@imag.fr www-lmc.imag.fr/lmc-cf/Gilles.Villard ABSTRACT We present a new algorithm to compute the Integer Smith normal form of large sparse matrices. We reduce the com- putation of the Smith form to independent

Villard, Gilles

282

Smith Normal Form of Dense Integer Matrices, Fast Algorithms into Practice #  

E-print Network

Smith Normal Form of Dense Integer Matrices, Fast Algorithms into Practice # David Saunders and Villard for computing the Smith form of an integer matrix. It is faster in practice, but with the same for the special case of a diagonal matrix. A local Smith form Algorithm is also considered. We o#er analysis

Bernstein, Daniel

283

78 FR 32250 - CDM Smith and Dynamac Corp; Transfer of Data  

Federal Register 2010, 2011, 2012, 2013, 2014

...EPA-HQ-OPP-2013-0036; FRL-9387-5] CDM Smith and Dynamac Corp; Transfer of Data AGENCY...submitter, will be transferred to CDM Smith and its subcontractor, Dynamac Corp...h)(3) and 2.308(i)(2). CDM Smith and its subcontractor, Dynamac...

2013-05-29

284

78 FR 2295 - Charlissa C. Smith; Establishment of Atomic Safety and Licensing Board  

Federal Register 2010, 2011, 2012, 2013, 2014

...13-925-01-SP-BD01] Charlissa C. Smith; Establishment of Atomic Safety and Licensing...the following proceeding: Charlissa C. Smith, (Denial of Senior Reactor Operator License...concerns a hearing request from Charlissa C. Smith, dated December 5, 2012,...

2013-01-10

285

77 FR 64411 - Safety Zone; Cooper T. Smith Fireworks Event; Mobile River; Mobile, AL  

Federal Register 2010, 2011, 2012, 2013, 2014

...RIN 1625-AA00 Safety Zone; Cooper T. Smith Fireworks Event; Mobile River; Mobile...navigable waters during the Cooper T. Smith Fireworks Event. Entry into, transiting...display. B. Basis and Purpose Cooper T. Smith Corp. has hired Pyro Tecnico to...

2012-10-22

286

76 FR 52691 - Captain John Smith Chesapeake National Historic Trail Advisory Council  

Federal Register 2010, 2011, 2012, 2013, 2014

...INTERIOR National Park Service Captain John Smith Chesapeake National Historic Trail Advisory...Advisory Committee on the Captain John Smith Chesapeake National Historic Trail will...the 1607-1609 voyages of Captain John Smith to chart the land and waterways of...

2011-08-23

287

77 FR 2317 - Captain John Smith Chesapeake National Historic Trail Advisory Council  

Federal Register 2010, 2011, 2012, 2013, 2014

...INTERIOR National Park Service Captain John Smith Chesapeake National Historic Trail Advisory...Advisory Committee on the Captain John Smith Chesapeake National Historic Trail will...the 1607-1609 voyages of Captain John Smith to chart the land and waterways of...

2012-01-17

288

76 FR 26767 - Captain John Smith Chesapeake National Historic Trail Advisory Council  

Federal Register 2010, 2011, 2012, 2013, 2014

...INTERIOR National Park Service Captain John Smith Chesapeake National Historic Trail Advisory...Advisory Committee on the Captain John Smith Chesapeake National Historic Trail will...the 1607-1609 voyages of Captain John Smith to chart the land and waterways of...

2011-05-09

289

Computation of the Smith normal form of polynomial matrices Gilles Villard  

E-print Network

Computation of the Smith normal form of polynomial matrices Gilles Villard Laboratoire LMC-lMAG, 46 of the Smith normal form of polynomial matrices. This algorithm computes the normal form and pre- and post establishes that pm- and post-multipliers for the Smith normal form of polynomial matrices can be computed

Villard, Gilles

290

A Fast Las Vegas Algorithm for Computing the Smith Normal Form of a Polynomial Matrix  

E-print Network

A Fast Las Vegas Algorithm for Computing the Smith Normal Form of a Polynomial Matrix Department algorithm is presented that nds the Smith normal form S 2 Q x]n n of a nonsingular input matrix A 2 ZZ x]n n sense. 1 Introduction The Smith normal form is a diagonalization of a matrix over a principal ideal

Waterloo, University of

291

James E. Smith J.B. Fuqua Professor of Business Administration  

E-print Network

James E. Smith J.B. Fuqua Professor of Business Administration Ph.D.Stanford University, 1990 James E. Smith is a Professor in the Decision Sciences area at the Fuqua School of Business at Duke University. He teaches courses in probability and statistics and decision modeling. Professor Smith

Reif, John H.

292

Near Optimal Algorithms for Computing Smith Normal Forms of Integer Matrices  

E-print Network

Near Optimal Algorithms for Computing Smith Normal Forms of Integer Matrices Arne Storjohann We present new algorithms for computing Smith normal forms of matrices over the integers and over the integers modulo d. For the case of matrices over Z d, we present an algorithm that computes the Smith form

Storjohann, Arne

293

Julius Smith Music 421 Applications Lecture 1 / 53 Historical Overview of Audio Spectral Modeling  

E-print Network

preamble #12;Julius Smith Music 421 Applications Lecture ­ 1 / 53 Historical Overview of Audio Spectral Modeling Julius Smith CCRMA, Stanford University Music 421 Applications Lecture January 7, 2014 Additive Synthesis FM Synthesis Sinusoidal Modeling Future Julius Smith Music 421 Applications Lecture ­ 2

Smith III, Julius Orion

294

78 FR 16286 - Neal Smith National Wildlife Refuge, Jasper County, IA; Final Comprehensive Conservation Plan and...  

Federal Register 2010, 2011, 2012, 2013, 2014

...FXRS1265030000-134-FF03R06000] Neal Smith National Wildlife Refuge, Jasper County...Environmental Assessment (EA) for Neal Smith National Wildlife Refuge (Refuge, NWR...r3planning@fws.gov. Include ``Neal Smith Final CCP'' in the subject line of...

2013-03-14

295

77 FR 64352 - Notice of Meeting for Captain John Smith Chesapeake National Historic Trail Advisory Council  

Federal Register 2010, 2011, 2012, 2013, 2014

...SZM] Notice of Meeting for Captain John Smith Chesapeake National Historic Trail Advisory...Advisory Committee on the Captain John Smith Chesapeake National Historic Trail will...the 1607-1609 voyages of Captain John Smith to chart the land and waterways of...

2012-10-19

296

Integer Smith Form via the Valence: Experience with Large Sparse Matrices from Homology  

E-print Network

Integer Smith Form via the Valence: Experience with Large Sparse Matrices from Homology J-G. Dumas. VALENCE BASED SMITH FORM ALGORITHM #12;3. COMPUTING THE VALENCE #12;3.1 Chinese remaindering 3.1.1 Degree 3.3 An Alternative to the Valence 4. LOCAL SMITH FORM AT P #12;4.1 Elimination Method 4.2 Iterative

Villard, Gilles

297

77 FR 12324 - Captain John Smith Chesapeake National Historic Trail Advisory Council  

Federal Register 2010, 2011, 2012, 2013, 2014

...INTERIOR National Park Service Captain John Smith Chesapeake National Historic Trail Advisory...Advisory Committee on the Captain John Smith Chesapeake National Historic Trail will...the 1607-1609 voyages of Captain John Smith to chart the land and waterways of...

2012-02-29

298

77 FR 50155 - Neal Smith National Wildlife Refuge, Jasper County, IA  

Federal Register 2010, 2011, 2012, 2013, 2014

...FXRS1265030000S3-123-FF03R06000] Neal Smith National Wildlife Refuge, Jasper County...environmental assessment (EA) for Neal Smith National Wildlife Refuge (Refuge, NWR...r3planning@fws.gov. Include ``Neal Smith Draft CCP/ EA'' in the subject...

2012-08-20

299

A Fast Las Vegas Algorithm for Computing the Smith Normal Form of a Polynomial Matrix  

E-print Network

A Fast Las Vegas Algorithm for Computing the Smith Normal Form of a Polynomial Matrix Arne that finds the Smith normal form S Q[x]n×n of a nonsingular input matrix A ZZ [x]n×n . The algorithm and practical sense. 1. INTRODUCTION The Smith normal form is a diagonalization of a matrix over a principal

Labahn, George

300

Corruption des travailleurs et ducation dans les socits commerciales selon Adam Smith1  

E-print Network

1 Corruption des travailleurs et éducation dans les sociétés commerciales selon Adam Smith1 Benoît Walraevens2 Résumé : Cet article vise à démontrer la richesse et l'originalité de l'analyse par Smith des effets déshumanisants de la division du travail. Nous soulignons tout d'abord comment Smith se

Boyer, Edmond

301

76 FR 4648 - PowerSmith Cogeneration Project, LP; Notice of Filing  

Federal Register 2010, 2011, 2012, 2013, 2014

...EL11-15-000; QF86-36-005] PowerSmith Cogeneration Project, LP; Notice of Filing January...that on January 13, 2011, PowerSmith Cogeneration Project, LP (PowerSmith), pursuant...Regulations for the topping-cycle cogeneration facility owned and operated by...

2011-01-26

302

77 FR 13593 - PowerSmith Cogeneration Project, LP; Notice of Request for Waiver  

Federal Register 2010, 2011, 2012, 2013, 2014

...EL12-37-000; QF86-36-006] PowerSmith Cogeneration Project, LP; Notice of Request for...18 CFR 292.205(c), PowerSmith Cogeneration Project, LP (PowerSmith) filed a...Regulations for the topping- cycle cogeneration facility owned and operated by...

2012-03-07

303

Edinburgh Research Explorer The Smith Commission and competition policymore power for  

E-print Network

Edinburgh Research Explorer The Smith Commission and competition policy­more power for Scottish Ministers? Citation for published version: Andreangeli, A, The Smith Commission and competition policy immediately and investigate your claim. Download date: 11. Dec. 2014 #12;The Smith Commission and competition

Millar, Andrew J.

304

The Hebrew University of Jerusalem The Robert H. Smith Faculty of Agriculture, Food & Environment  

E-print Network

The Hebrew University of Jerusalem The Robert H. Smith Faculty of Agriculture, Food & Environment H. Smith Faculty of Agriculture, Food & Environment, Herzl Street, POB 12, Rehovot, Israel 7610001 Studies of the Hebrew University's Robert H. Smith Faculty of Agriculture, Food & Environment

Anat, Maril,

305

APOBEC3G: a Double Agent in Defense Harold C. Smith  

E-print Network

APOBEC3G: a Double Agent in Defense Harold C. Smith Department of Biochemistry and Biophysics to A3G having a requirement for a ssDNA Corresponding Author contacts: Harold C. Smith, Department and Dentistry, Rochester, NY 14642 USA, harold.smith@rochester.edu Voice: (585) 275-4267, FAX: (585) 275

Levin, Judith G.

306

Bernard Mandeville's heir: Adam Smith or Jean Jacques Rousseau on the possibility of economic analysis  

Microsoft Academic Search

In this paper I argue that Bernard Mandeville, Jean Jacques Rousseau and Adam Smith are confronted to the same question: how to explain values from a naturalistic origin of morality. An in-depth analysis of their theories of human nature and market society will show that Rousseau is further from Mandeville's analysis than Smith acknowledged, and it is Smith who will

Jimena Hurtado Prieto

2004-01-01

307

Vorticity and Divergence of Surface Velocities Near Shore JEROME A. SMITH  

E-print Network

Vorticity and Divergence of Surface Velocities Near Shore JEROME A. SMITH Scripps Institution, and nearshore mixing-scale motions are generally undersampled (but see, e.g., Smith and Largier 1995; Johnson m 300 m on a side (Smith 2002a,b). Thus, these data focus more toward the small end of the range

Smith, Jerome A.

308

PLEASE SCROLL DOWN FOR ARTICLE This article was downloaded by: [Smith, Bradley  

E-print Network

PLEASE SCROLL DOWN FOR ARTICLE This article was downloaded by: [Smith, Bradley] On: 19 March 2009 of stopper size on squaraine rotaxane stability Na Fu a ; Jeremiah J. Gassensmith a ; Bradley D. Smith: 01 January 2009 To cite this Article Fu, Na, Gassensmith, Jeremiah J. and Smith, Bradley D.(2009

Smith, Bradley D.

309

PLEASE SCROLL DOWN FOR ARTICLE This article was downloaded by: [Smith, Lloyd V.  

E-print Network

PLEASE SCROLL DOWN FOR ARTICLE This article was downloaded by: [Smith, Lloyd V.] On: 21 February and challenges in numerically modelling solid sports balls with application to softballs Lloyd V. Smith, Washington, USA First Published:January2009 To cite this Article Smith, Lloyd V. and Duris, Joseph G.(2009

Smith, Lloyd V.

310

A Cabinet of Mathematical Curiosities at Teachers College: David Eugene Smith's Collection  

ERIC Educational Resources Information Center

This dissertation is a history of David Eugene Smith's collection of historical books, manuscripts, portraits, and instruments related to mathematics. The study analyzes surviving documents, images, objects, college announcements and catalogs, and secondary sources related to Smith's collection. David Eugene Smith (1860-1944) travelled…

Murray, Diane R.

2012-01-01

311

Inequality and the Dayton Tax-Budget Plan Jay Coggins and Dane Smith  

E-print Network

Inequality and the Dayton Tax-Budget Plan Jay Coggins and Dane Smith Department of Applied Economics University of Minnesota March 6, 2013 Jay Coggins and Dane Smith Inequality and the Dayton Tax Jay Coggins and Dane Smith Inequality and the Dayton Tax-Budget Plan #12;Size of chart needed for Ray

Weiblen, George D

312

orignal paper: Beyond natural selection and divine intervention: The Lamarckian implication of Adam Smith's invisible hand  

Microsoft Academic Search

Adam Smith's invisible hand metaphor (IH) is examined in light of two different accounts of the origin of traits: Charles Darwin's theory of evolutionary optimization and William Paley's theory of divine intervention. Smith's stand supersedes both accounts. For Smith, intermediating drives, such as the sexual one, neither arise accidentally and favored according to their fitness , la Darwin nor planted

Elias L. Khalil

2000-01-01

313

Alson H. Smith Jr. Agricultural Research and Extension Center Physical Resources  

E-print Network

Alson H. Smith Jr. Agricultural Research and Extension Center Physical Resources Land.arec.vaes.vt.edu/alson-h-smith #12;AlsonH.SmithJr.AgriculturalResearchandExtensionCenter Virginia Tech does not discriminate against Wolf, 540/869-2560, vitis@vt.edu Resident Faculty Faculty Research and Extension Focus Areas Chris

Liskiewicz, Maciej

314

Aerospace EngineeringSmith & Valasek 1 Comparison of Traditional Agility Metrics  

E-print Network

Aerospace EngineeringSmith & Valasek 1 Comparison of Traditional Agility Metrics to Beck Performance and Agility Metrics Using Linear Error Theory David Smith John Valasek Aerospace Engineering, Texas A&M University 16 August 2000 #12;Aerospace EngineeringSmith & Valasek 2 OVERVIEW · AGILITY

Valasek, John

315

77 FR 71636 - Huntington Foam LLC, Fort Smith, AR; Notice of Revised Determination on Reconsideration  

Federal Register 2010, 2011, 2012, 2013, 2014

...TA-W-81,475] Huntington Foam LLC, Fort Smith, AR; Notice...former workers of Huntington Foam LLC, Fort Smith, Arkansas...polystyrene shape molded parts (packaging and internal components for...determine that workers of Huntington Foam LLC, Fort Smith,...

2012-12-03

316

Smith Lever Act Cooperative extension work between the Land-Grant Colleges and the United State  

E-print Network

Smith Lever Act Cooperative extension work between the Land-Grant Colleges and the United State Department of Agriculture is authorized by the Smith-Lever Act. The provisions of the Act, in effect in Oregon Oregon 4-H Program Handbook Smith Lever Act February 1995 The amount paid by the Federal

Tullos, Desiree

317

Nest architecture of Pachycondyla striata Fr. Smith, 1858 (Formicidae, Ponerinae)  

Microsoft Academic Search

Nine nests of Pachycondyla striata Fr. Smith, 1858 were excavated between 2006 and 2007 at the UNESP university campus in Rio Claro, SP, southeastern Brazil. The P. striata population was larger in the two nests excavated in the months of August and November, 2006. The nests of this species are\\u000a simple and poorly elaborated, with chambers and tunnels close to

A. da Silva-Melo; E. Giannotti

2010-01-01

318

James M. Coughlan Smith-Kettlewell Eye Research Institute  

E-print Network

of the Problem 3-D lines in Manhattan scene project to lines on uv image plane. cr ar fu rr rr = cr br fv rr rrJames M. Coughlan Smith-Kettlewell Eye Research Institute Manhattan World: Orientation and Outlier Detection by Bayesian Inference #12;Application of the statistics of edges: Manhattan World Many scenes

Coughlan, James M.

319

Erin Ann Smith Associate Professor of American Studies and Literature  

E-print Network

B.S. with high honor, June 1991, Michigan State University, East Lansing, MI, Social Science "TheErin Ann Smith Associate Professor of American Studies and Literature School of Interdisciplinary Literature and Culture B.A. with high honor, June 1991, Michigan State University, East Lansing, MI, English

O'Toole, Alice J.

320

Obituary: Harding Eugene (Gene) Smith, Jr., 1947-2007  

Microsoft Academic Search

Harding Eugene Smith Junior, or Gene, as he was known to family, friends, and colleagues, passed away after an automobile accident in Encinitas, California, on 16 August 2007. He was 60 years old. Gene had recently retired from UCSD after thirty years of service. A memorial service was held at Quail Botanical Gardens in Encinitas, California, on 23 August 2007.

Carol Lonsdale; Tom Soifer

2009-01-01

321

Position Paper: Processing sound for interpretation. Dr. Leslie S. Smith  

E-print Network

Position Paper: Processing sound for interpretation. Dr. Leslie S. Smith Centre for Cognitive and Computational Neuroscience Departments of Computing Science and Psychology University of Stirling Stirling FK9 4 view of sound perception strongly influenced by J.J. Gibson, we consider what the sound itself can

Smith, Leslie S.

322

Harry Smith — recipient of the 2008 Molecular Ecology Prize  

Technology Transfer Automated Retrieval System (TEKTRAN)

Harry Smith is a scholar, mentor, internationally renowned researcher, eloquent speaker and author, pioneering journal editor and highly valued colleague who has contributed greatly in multiple ways to plant science and the community. He richly deserves the honour of the Molecular Ecology Prize....

323

May Branch, Fort Smith, AR 12 October 2006  

E-print Network

the city limits of Fort Smith, Sebastian County, Arkansas. May Branch originates in the south central section of the city and flows to the north and northwest to the Arkansas River. The study reach is from the confluence of M Branch with the Arkansas River upstream approximately 3 miles. ay The Proposed Pan

US Army Corps of Engineers

324

The Garrett Lee Smith Memorial Suicide Prevention Program  

ERIC Educational Resources Information Center

In response to calls for greater efforts to reduce youth suicide, the Garrett Lee Smith (GLS) Memorial Act has provided funding for 68 state, territory, and tribal community grants, and 74 college campus grants for suicide prevention efforts. Suicide prevention activities supported by GLS grantees have included education, training programs…

Goldston, David B.; Walrath, Christine M.; McKeon, Richard; Puddy, Richard W.; Lubell, Keri M.; Potter, Lloyd B.; Rodi, Michael S.

2010-01-01

325

Pharmacological Cognitive Enhancers: Comment on Smith and Farah (2011)  

ERIC Educational Resources Information Center

Smith and Farah (2011) provided a thought-provoking and perhaps deliberately provocative literature review of the use of stimulants to improve cognitive functioning in humans. They addressed the apparently increasing willingness of individuals mostly in the United States to use stimulants for this purpose and then summarized published literature…

Elliott, Glen R.; Elliott, Mark D.

2011-01-01

326

SAMPLE COVER LETTER for BIOTECH INTERNSHIP Aaron Smith  

E-print Network

SAMPLE COVER LETTER for BIOTECH INTERNSHIP Aaron Smith 12 Echo Street Cambridge, MA 55555 September 14, 20xx Ms. Caroline Burnett Boston Biotech Company Somewhere, MA 55555 Dear Ms. Burnett job listings at the Brandeis University Career Center. Boston Biotech is a leader in the advancement

Fraden, Seth

327

Science fictions: Comment on Godfrey-Smith Arthur Fine  

E-print Network

Science fictions: Comment on Godfrey-Smith Arthur Fine Published online: 2 December 2008 Ã? Springer and Fictions in Science''. The comments explore problems he raises if we treat model systems as fictions in science and one of the earliest sustained treatments of those models and their elements as fictions

Fine, Arthur

328

TROPHIC DYNAMICS OF STRIPED BASS IN SMITH MOUNTAIN LAKE, VIRGINIA  

EPA Science Inventory

We examined the adequacy of the forage base to meet demand of striped bass in Smith Mountain Lake, Virginia. In regards to prey supply, mean alewife biomass from 1993-1998 was 37 kg/ha and mean gizzard shad biomass from 1990-1997 was 112 kg/ha. Mean annual alewife surplus produ...

329

Karen Smith: Language Arts Educator of the Year  

ERIC Educational Resources Information Center

This article honors Karen Smith, who has been given NCTE's Outstanding Educator in the English Language Arts award for 2009. Through the voices of many colleagues and former students, the article celebrates Karen as a teacher, learner, mentor, collaborator, scholar, storyteller, and visionary thinker and doer.

Hudelson, Sarah

2009-01-01

330

Titan's atomic and molecular nitrogen tori H. T. Smith,1  

E-print Network

Titan's atomic and molecular nitrogen tori H. T. Smith,1 R. E. Johnson,1 and V. I. Shematovich2] Shematovich et al. recently showed plasma induced sputtering in Titan's atmosphere is a source of neutral a toroidal nitrogen cloud roughly centered at Titan's orbital radius but gravitationally bound to Saturn

Johnson, Robert E.

331

The futility of utility: how market dynamics marginalize Adam Smith  

Microsoft Academic Search

Economic theorizing is based on the postulated, nonempiric notion of utility. Economists assume that prices, dynamics, and market equilibria are supposed to be derived from utility. The results are supposed to represent mathematically the stabilizing action of Adam Smith's invisible hand. In deterministic excess demand dynamics I show the following. A utility function generally does not exist mathematically due to

Joseph L. McCauley

2000-01-01

332

Looking east at canal and R. Paul Smith Power Station. ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Looking east at canal and R. Paul Smith Power Station. The dark trestle at right center carried the spur track to coal unloading facilities located in the space now occupied by the coal pile. - Potomac Edison Company, Chesapeake & Ohio Canal Bridge, Spanning C & O Canal South of U.S. 11, Williamsport, Washington County, MD

333

Ants (Formicidae): Models for Social Complexity Chris R. Smith,1  

E-print Network

Ants (Formicidae): Models for Social Complexity Chris R. Smith,1 Adam Dolezal, Dorit Eliyahu, C INTRODUCTION The family Formicidae (ants) is composed of more than 12,000 described species that vary greatly in size, morphology, behavior, life history, ecology, and social organization. Ants occur in most

Tschinkel, Walter R.

334

Variable efficacy of repeated annual influenza vaccination Derek J. Smith,  

E-print Network

Variable efficacy of repeated annual influenza vaccination Derek J. Smith, ¢¡ Stephanie Forrest-665-3493. Running head: Annual influenza vaccination. Classification: Medical Science Keywords: influenza, vaccination, original antigenic sin, vaccine efficacy, repeated vaccination. 1 #12;ABSTRACT Conclusions have

Forrest, Stephanie

335

A plausible model of phyllotaxis Richard S. Smith*  

E-print Network

A plausible model of phyllotaxis Richard S. Smith* , Soazig Guyomarc'h , Therese Mandel , Didier by Reinhardt et al. [Reinhardt, D., Pesce, E. R., Stieger, P., Mandel, T., Baltensperger, K., et al. (2003 indole-3-acetic acid (IAA) to such pin-shaped meristems induced lateral primordia, with the size

Prusinkiewicz, Przemyslaw

336

PYTHAGOREAN -FIELDS Thomas C. Craven and Tara L. Smith  

E-print Network

PYTHAGOREAN -FIELDS Thomas C. Craven and Tara L. Smith Abstract. We generalize the usual notion of pythagorean field (every sum of squares is a square) to the setting of division rings D with involution. We group homomorphism of the Witt group of anisotropic hermitian forms W(D, ) into C(YD, Z) [Cr3, Theorem 2

Craven, Thomas C.

337

A Survey of Software Fault Tolerance Techniques Jonathan M. Smith  

E-print Network

points are life­critical systems [Leveson1986a], where the dependence on the system could determine­­ ­­ A Survey of Software Fault Tolerance Techniques Jonathan M. Smith Computer Science Department, Columbia University, New York, NY 10027 ABSTRACT This report examines the state of the field of software

338

Smith and Valley-Gray to Lead NASP  

ERIC Educational Resources Information Center

The 2011 elections are complete and Amy Smith has been elected to lead NASP in 2012. Amy has a long history of serving her state and national professional organizations, most recently as NASP program manager for advocacy and before that as the Pennsylvania delegate and Northeast Region delegate representative. She served the Association of School…

Deupree, Charles

2011-01-01

339

Functional Food Product Development Jim Smith and Edward Charter  

E-print Network

Functional Food Product Development Edited by Jim Smith and Edward Charter Prince Edward Island Food Technology Centre Charlottetown, Canada A John Wiley & Sons, Ltd., Publication #12;#12;Functional Food Product Development #12;A John Wiley & Sons, Ltd., Publication Functional Food Science

Haddadi, Hamed

340

Smith-Magenis Syndrome: Genetic Basis and Clinical Implications  

ERIC Educational Resources Information Center

Smith-Magenis syndrome (SMS) is a neurobehavioral disorder associated with deletions and mutations of the "RAI1" gene on chromosome 17p11.2. Clinical features of the syndrome include intellectual disability, sleep disturbance, craniofacial differences, and a distinctive profile of stereotypic and self-injurious behaviors. Although the functional…

Finucane, Brenda; Haas-Givler, Barbara

2009-01-01

341

James Webb Space Telescope (JWST) Eric P. Smith  

E-print Network

1! James Webb Space Telescope (JWST) Eric P. Smith Program Status and Replan October 2011 #12 Webb Space Telescope JWST is the scientific and technological successor to HST and Spitzer HST has on line:" http://www.jwst.nasa.gov/resources/ JamesWebbSpaceTelescope

Rathbun, Julie A.

342

The dispersion equation of the induced Smith-Purcell instability  

E-print Network

system was observed, has stimulated new investigations concerning the SP FEL as an open slow wave-electron lasers and other slow-wave devices. More recently, Kim and Song [3] have proposed a theory in which structure [3, 4, 5, 6, 7, 8, 9]. Several theories have been proposed to describe the operation of a Smith

343

AARON SMITH Department of Agricultural and Resource Economics  

E-print Network

AARON SMITH Department of Agricultural and Resource Economics One Shields Ave, University.ucdavis.edu Employment Professor, 2014-present, Department of Agricultural and Resource Economics, University of California, Davis. Associate Professor, 2007-2014, Department of Agricultural and Resource Economics, UC

California at Davis, University of

344

Adam Smith and the Teaching of English Literature.  

ERIC Educational Resources Information Center

Adam Smith used selections from English literature in his classroom during the eighteenth century because he believed that vernacular literature could provide a ready context for the teaching of ideological, social, and moral lessons. He believed that higher education should prepare students for the real business of the real world. (RM)

Court, Franklin E.

1985-01-01

345

Adam Smith and the Moral Economy of the Classroom System.  

ERIC Educational Resources Information Center

Traces the development of mass schooling to its origins in 19th-century Glasgow. Its importance as an intellectual and economic center enabled Glasgow to invent a solution to the problem of urban schooling, while the association of scholars like Adam Smith with Glasgow University made Scottish educational theories acceptable around the world. (DB)

Hamilton, D.

1980-01-01

346

ON ADAM SMITH AND A THEORY OF TECHNOLOGY  

Microsoft Academic Search

Review of definitions and theoretical works concerning technology suggests that different disciplinary frameworks lead to very different interpretations of that basic term. These interpretations are presented in the literature of such disciplines as economics, philosophy, sociology, psychology etc. In search for coherent background and a model of technology, a study of Adam Smith's (1723 - 1790) historic works and statements

Karol I. Pelc

347

Retour à Adam Smith (1723-1790) après deux siècles?  

Microsoft Academic Search

After a review of current assessments of Smithian economics, the author stresses the interest of the entire system at historical, sociological and ethical levels. The renewed interest in Smith comes from his ethical positions rather than from his skills as an economic analyst. The solution to the vexing problem of ever finding an acceptable ethics in distribution theory seems to

Gérard-R. Pelletier

1990-01-01

348

Technological progress and economic analysis from Petty to Smith  

Microsoft Academic Search

Both William Petty (1623 to 1687) and Adam Smith (1723 to 1790) were concerned with the question of how to increase productivity. In this connection, they both addressed the issues of technological invention and the organisation of the production process, but in very different ways. Petty represents both these aspects of the productivity question as instances of another, conceptually dominant,

Hugh Goodacre

2010-01-01

349

Theory and Design of Smith-Purcell Semiconductor Terahertz Sources  

E-print Network

difficulties reaching the THz, and no THz device of any type operates on the full range at room temperature. This dissertation proposes a novel semiconductor source which utilizes the transferred-electron (Gunn) effect and the Smith-Purcell effect to operate...

Smith, Don DeeWayne

2013-12-06

350

X-29 Research Pilot Rogers Smith  

NASA Technical Reports Server (NTRS)

Rogers Smith, a NASA research pilot, is seen here at the cockpit of the X-29 forward-swept-wing technology demonstrator at NASA's Ames-Dryden Flight Research Facility (later the Dryden Flight Research Center), Edwards, California, in 1988. The X-29 explored the use of advanced composites in aircraft construction; variable camber wing surfaces; the unique forward-swept-wing and its thin supercritical airfoil; strake flaps; and a computerized fly-by-wire flight control system that overcame the aircraft's instability. Grumman Aircraft Corporation built two X-29s. They were flight tested at Dryden from 1984 to 1992 in a joint NASA, DARPA (Defense Advanced Research Projects Agency) and U.S. Air Force program. Two X-29 aircraft, featuring one of the most unusual designs in aviation history, flew at the Ames-Dryden Flight Research Facility (now the Dryden Flight Research Center, Edwards, California) from 1984 to 1992. The fighter-sized X-29 technology demonstrators explored several concepts and technologies including: the use of advanced composites in aircraft construction; variable-camber wing surfaces; a unique forward- swept wing and its thin supercritical airfoil; strakes; close-coupled canards; and a computerized fly-by-wire flight control system used to maintain control of the otherwise unstable aircraft. Research results showed that the configuration of forward-swept wings, coupled with movable canards, gave pilots excellent control response at angles of attack of up to 45 degrees. During its flight history, the X-29 aircraft flew 422 research missions and a total of 436 missions. Sixty of the research flights were part of the X-29 follow-on 'vortex control' phase. The forward-swept wing of the X-29 resulted in reverse airflow, toward the fuselage rather than away from it, as occurs on the usual aft-swept wing. Consequently, on the forward-swept wing, the ailerons remained unstalled at high angles of attack. This provided better airflow over the ailerons and prevented stalling (loss of lift) at high angles of attack. Introduction of composite materials in the 1970s opened a new field of aircraft construction. It also made possible the construction of the X-29's thin supercritical wing. State-of-the-art composites allowed aeroelastic tailoring which, in turn, allowed the wing some bending but limited twisting and eliminated structural divergence within the flight envelope (i.e. deformation of the wing or the wing breaking off in flight). Additionally, composite materials allowed the wing to be sufficiently rigid for safe flight without adding an unacceptable weight penalty. The X-29 project consisted of two phases plus the follow-on vortex-control phase. Phase 1 demonstrated that the forward sweep of the X-29 wings kept the wing tips unstalled at the moderate angles of attack flown in that phase (a maximum of 21 degrees). Phase I also demonstrated that the aeroelastic tailored wing prevented structural divergence of the wing within the flight envelope, and that the control laws and control-surface effectiveness were adequate to provide artificial stability for an otherwise unstable aircraft. Phase 1 further demonstrated that the X-29 configuration could fly safely and reliably, even in tight turns. During Phase 2 of the project, the X-29, flying at an angle of attack of up to 67 degrees, demonstrated much better control and maneuvering qualities than computational methods and simulation models had predicted . During 120 research flights in this phase, NASA, Air Force, and Grumman project pilots reported the X-29 aircraft had excellent control response to an angle of attack of 45 degrees and still had limited controllability at a 67-degree angle of attack. This controllability at high angles of attack can be attributed to the aircraft's unique forward-swept wing- canard design. The NASA/Air Force-designed high-gain flight control laws also contributed to the good flying qualities. During the Air Force-initiated vortex-control phase, the X-29 successfully demonstrated vortex flow control (VFC). This VFC was more effective t

1988-01-01

351

Benzene Exposure and Risk of Non-Hodgkin Lymphoma Martyn T. Smith, Rachael M. Jones, and Allan H. Smith  

E-print Network

Benzene Exposure and Risk of Non-Hodgkin Lymphoma Martyn T. Smith, Rachael M. Jones, and Allan H of California, Berkeley, California Abstract Exposure to benzene, an important industrial chemical and component studies that identified probable occupational exposures to benzene and NHL morbidity or mortality. We

California at Berkeley, University of

352

SMITH: a LIMS for handling next-generation sequencing workflows  

PubMed Central

Background Life-science laboratories make increasing use of Next Generation Sequencing (NGS) for studying bio-macromolecules and their interactions. Array-based methods for measuring gene expression or protein-DNA interactions are being replaced by RNA-Seq and ChIP-Seq. Sequencing is generally performed by specialized facilities that have to keep track of sequencing requests, trace samples, ensure quality and make data available according to predefined privileges. An integrated tool helps to troubleshoot problems, to maintain a high quality standard, to reduce time and costs. Commercial and non-commercial tools called LIMS (Laboratory Information Management Systems) are available for this purpose. However, they often come at prohibitive cost and/or lack the flexibility and scalability needed to adjust seamlessly to the frequently changing protocols employed. In order to manage the flow of sequencing data produced at the Genomic Unit of the Italian Institute of Technology (IIT), we developed SMITH (Sequencing Machine Information Tracking and Handling). Methods SMITH is a web application with a MySQL server at the backend. Wet-lab scientists of the Centre for Genomic Science and database experts from the Politecnico of Milan in the context of a Genomic Data Model Project developed SMITH. The data base schema stores all the information of an NGS experiment, including the descriptions of all protocols and algorithms used in the process. Notably, an attribute-value table allows associating an unconstrained textual description to each sample and all the data produced afterwards. This method permits the creation of metadata that can be used to search the database for specific files as well as for statistical analyses. Results SMITH runs automatically and limits direct human interaction mainly to administrative tasks. SMITH data-delivery procedures were standardized making it easier for biologists and analysts to navigate the data. Automation also helps saving time. The workflows are available through an API provided by the workflow management system. The parameters and input data are passed to the workflow engine that performs de-multiplexing, quality control, alignments, etc. Conclusions SMITH standardizes, automates, and speeds up sequencing workflows. Annotation of data with key-value pairs facilitates meta-analysis. PMID:25471934

2014-01-01

353

Fenimore Art Museum: The Smith and Telfer Photographic Collection  

NSDL National Science Digital Library

The Fenimore Art Museum in New York has a wide-ranging collection that includes significant pieces of American Indian art, folk art, and thousands of photographs and negatives. Working together with other institutions, including the New York State Historical Association, they have digitized over 300 images from the Smith and Telfer Photographic Collection. The firm of Smith and Telfer documented the town of Cooperstown, NY for well over a century, and they took photos of circus animals, civic monuments, and prominent individuals. Visitors can browse through the images at their leisure, and they can also search the entire collection by keyword. A couple of images of note include the shot of a man holding a dog in his lap while sitting on a tractor ("Ainslie Cornfield") and the photo entitled "Balloon Ascension".

354

Constitutive relations associated with the Mott-Smith distribution function  

NASA Technical Reports Server (NTRS)

It is shown that the distribution function assumed by Mott-Smith determines a unique relation between heat flux, stress, and fluid velocity given by q = (3/2) tau u - i.e., it provides a constitutive relation for heat flux, and it also determines a simple expression for the ratio of third-order central moments. These expressions allow the equation of transfer for (C sub x) squared to be cast in a form that yields a nonlinear constitutive relation for stress. The results obtained from the Mott-Smith ansatz are compared with the theory of Baganoff and Nathenson (1970) and results from a numerical solution of the Boltzmann equation for shock-wave structure obtained by Hicks et al. (1972).

Nathenson, M.; Baganoff, D.

1973-01-01

355

Constitutive relations associated with the Mott-Smith distribution function  

USGS Publications Warehouse

It is shown that the distribution function assumed by Mott-Smith determines a unique relation between heat flux, stress, and fluid velocity given by q = (3/2)??u, i.e., it provides a constitutive relation for heat flux, and it also determines a simple expression for this ratio of third-order central moments Q = . These expressions allow the equation of transfer for c x2 to be cast in a form that yields a nonlinear constitutive relation for stress. The results obtained from the Mott-Smith ansatz are compared with the theory of Baganoff and Nathenson and results from a numerical solution of the Boltzmann equation for shock-wave structure obtained by Hicks and Yen.

Nathenson, M.; Baganoff, D.

1973-01-01

356

Defenses and morality: Adam Smith, Sigmund Freud, and contemporary psychoanalysis.  

PubMed

In this paper we follow the development and transmission of moral learning from Adam Smith's impartial spectator to Sigmund Freud's superego and then to contemporary psychoanalysis. We argue that defenses are an integral component in the acquisition of any moral system. Elaborating on this argument, we assert that there is a progression from defensive systems that are "closed" to defensive systems that are "open," as defined in a recent work by Novick and Novick. The former system is "static, avoids reality, and is characterized by power dynamics, sadomasochism, and omnipotent defense." The latter, on the other hand, is a system that allows for "joy, creativity, spontaneity, love and it is attuned to reality." Furthermore, while Smith and Freud's systems are more one-person systems of defense, contemporary psychoanalysis has moved to more of a two-person system. PMID:25247288

Gabrinetti, Paul A; Özler, Sule

2014-10-01

357

Ian Humphery-Smith on current challenges in proteomics  

Microsoft Academic Search

Ian Humphery-Smith is Professor of Pharmaceutical Proteomics at Utrecht University, The Netherlands, and until recently was a Managing Director and Chief Scientific Officer of Glaucus Proteomics. After a PhD in Parasitology at the University of Queensland, he studied virology and bacteriology in France as a post-doc, before returning to Australia as Course-Coordinator in Medical Microbiology and Immunology at the University

Joanna Owens

2003-01-01

358

Smith Newton Vehicle Performance Evaluation - 3rd Quarter 2012 (Brochure)  

SciTech Connect

The Fleet Test and Evaluation Team at the U.S. Department of Energy's National Renewable Energy Laboratory is evaluating and documenting the performance of electric and plug-in hybrid electric drive systems in medium-duty trucks across the nation. Through this project, Smith Electric Vehicles will build and deploy 500 all-electric medium-duty trucks. The trucks will be deployed in diverse climates across the country.

Not Available

2013-03-01

359

Building Energy Audit Report for Camp Smith, HI  

SciTech Connect

A detailed energy assessment was performed by a team of engineers from Pacific Northwest National Laboratory (PNNL) under contract to the Department of Energy/Federal Energy Management program (FEMP). The effort used the Facility Energy Decision System (FEDS) model to determine how energy is consumed at Camp Smith, identify the most cost-effective energy retrofit measures, and calculate the potential energy and cost savings. This report documents the results of that assessment.

Chvala, William D.; De La Rosa, Marcus I.; Brown, Daryl R.; Dixon, Douglas R.

2010-09-30

360

Paternity and paternal care in the polygynandrous Smith's longspur  

Microsoft Academic Search

In species where females copulate with more than one male during a single breeding attempt, males risk investing in offspring\\u000a that are not their own. In the polygynandrous Smith's longspur (Calcarius pictus), females copulate sequentially with one to three males for each clutch of eggs and most of these males later assist in feeding\\u000a the young. Using multilocus DNA profiling,

James V. Briskie; Robert Montgomerie; Tarmo Põldmaa; Peter T. Boag

1998-01-01

361

Smith-Magneis syndrome: behavioural phenotype mimics ADHD.  

PubMed

A mentally retarded 7-year-old male child presented with inattention and hyperactivity which was initially diagnosed as attention deficit hyperactivity disorder (ADHD). However, a careful evaluation of symptomatology along with clues provided by specific features of facial dysmorphism in this case along with genetic testing clinched the diagnosis of Smith-Magneis syndrome the behavioural phenotype of which closely resembles ADHD. PMID:24395876

Gnanavel, Sundar

2014-01-01

362

Definition of the critical interval for Smith-Magenis syndrome  

Microsoft Academic Search

Smith-Magenis syndrome (SMS) comprises a complex physical and behavioral phenotype that is associated with an interstitial deletion of chromosome 17p11.2. The deletions observed in patients can range from <2 to >9 megabases of DNA and may include more than 100 genes. In order to determine the critical deletion interval responsible for the syndrome phenotype, we have examined several patients with

S. H. Elsea; S. M. Purandare; R. A. Adell; R. C. Juyal; J. G. Davis; B. Finucane; R. E. Magenis; P. I. Patel

1997-01-01

363

Smith-Magenis syndrome and growth hormone deficiency  

Microsoft Academic Search

Smith-Magenis syndrome (SMS) is a multiple congenital anomaly\\/mental retardation syndrome including physical and neurobehavioural features. The disease is commonly associated with a ca. 3.7 Mb interstitial deletion of chromosome 17p11.2, while a 1.1 Mb critical region has been identified, containing about 20 genes expressed in multiple tissues. Haploinsufficiency of one of them, RAI1, seems to be responsible for the neurobehavioural, craniofacial and

Emanuela Spadoni; Patrizia Colapietro; Mauro Bozzola; Gian L. Marseglia; Luciana Repossi; Cesare Danesino; Lidia Larizza; Paola Maraschio

2004-01-01

364

Smith-Magenis Syndrome: Genetic Basis and Clinical Implications  

Microsoft Academic Search

Smith-Magenis syndrome (SMS) is a neurobehavioral disorder associated with deletions and mutations of the RAI1 gene on chromosome 17p11.2. Clinical features of the syndrome include intellectual disability, sleep disturbance, craniofacial differences, and a distinctive profile of stereotypic and self-injurious behaviors. Although the functional role of RAI1 and neighboring genes is not completely understood, disruption of these genes is thought to

Brenda Finucane; Barbara Haas-Givler

2009-01-01

365

STANDARDS-BASED ISO TC37/SC4;founde r m e m be r ofO ASIS/UIMA  

E-print Network

COM M ERCIALUSERS ·Glaxo Sm ith Kline PLC ·AT& T ·Maste r Foods NV ·British Gas PLC ·Syntale x Ltd. ·Le rnoutH auspie Gm bh . ·Th om pson Corp ·Innovantage ·Garlik ·Fizzback ·Spock GATE h as b e e n

Maynard, Diana

366

Wayne Smith Leadership Award Application The Wayne Smith Leadership Award was established "To be used at the discretion of the Director of the School  

E-print Network

Wayne Smith Leadership Award Application The Wayne Smith Leadership Award was established "To be used at the discretion of the Director of the School to support leadership of professional projects of student organizations in the School and/or to support student leaders who participate in formal leadership

Watson, Craig A.

367

Smith-Purcell free electron laser based on a semi-conical resonator  

NASA Astrophysics Data System (ADS)

We investigate a Smith-Purcell free electron laser composed of an electron gun, a semi-conical resonator, a metallic grating and collector. The semi-conical resonator could reflect all Smith-Purcell radiation with emission angle ?, and with random azimuthal angles, back onto the electron beam and causes the electrons to be modulated. Tunable coherent far-infrared Smith-Purcell radiation with a high output peak power at millimeter wavelengths can be generated.

Meng (???), Xianzhu

2012-03-01

368

Beyond natural selection and divine intervention: The Lamarckian implication of Adam Smith's invisible hand  

Microsoft Academic Search

.   Adam Smith's invisible hand metaphor (IH) is examined in light of two different accounts of the origin of traits: Charles\\u000a Darwin's theory of evolutionary optimization and William Paley's theory of divine intervention. Smith's stand supersedes both\\u000a accounts. For Smith, intermediating drives, such as the sexual one, neither arise accidentally and favored according to their\\u000a fitness à la Darwin nor

Elias L. Khalil

2000-01-01

369

Kitchen surgery and house calls in old Fort Smith.  

PubMed

Medical practice in the late nineteenth and early twentieth centuries consisted largely of kitchen surgery and house calls. The practices of Dr. St. Cloud Cooper and other Fort Smith doctors reflected the standards of practice in Arkansas and the nation as the principles of aseptic surgery gradually gained acceptance. The doctor's black bag used on house calls still lacked the effective agents which became available during the mid-twentieth century, leaving the physician to rely on personal inner resources in order to perform a useful service. PMID:24079057

Prewitt, Taylor

2013-09-01

370

Smith Newton Vehicle Performance Evaluation - Gen 2 - Cumulative (Brochure)  

SciTech Connect

The Fleet Test and Evaluation Team at the U.S. Department of Energy's National Renewable Energy Laboratory is evaluating and documenting the performance of electric and plug-in hybrid electric drive systems in medium-duty trucks across the nation. U.S. companies participating in this evaluation project received funding from the American Recovery and Reinvestment Act to cover part of the cost of purchasing these vehicles. Through this project, Smith Electric Vehicles is building and deploying 500 all-electric medium-duty trucks that will be deployed by a variety of companies in diverse climates across the country.

Not Available

2014-08-01

371

Smith Newton Vehicle Performance Evaluation - Gen2 - 2013 (Brochure)  

SciTech Connect

The Fleet Test and Evaluation Team at the U.S. Department of Energy's National Renewable Energy Laboratory is evaluating and documenting the performance of electric and plug-in hybrid electric drive systems in medium-duty trucks across the nation. U.S. companies participating in this evaluation project received funding from the American Recovery and Reinvestment Act to cover part of the cost of purchasing these vehicles. Through this project, Smith Electric Vehicles is building and deploying 500 all-electric medium-duty trucks that will be deployed by a variety of companies in diverse climates across the country.

Not Available

2014-04-01

372

Smith Newton Vehicle Performance Evaluation - 1st Quarter 2014 (Brochure)  

SciTech Connect

The Fleet Test and Evaluation Team at the U.S. Department of Energy's National Renewable Energy Laboratory is evaluating and documenting the performance of electric and plug-in hybrid electric drive systems in medium-duty trucks across the nation. U.S. companies participating in this evaluation project received funding from the American Recovery and Reinvestment Act to cover part of the cost of purchasing these vehicles. Through this project, Smith Electric Vehicles is building and deploying 500 all-electric medium-duty trucks that will be deployed by a variety of companies in diverse climates across the country.

Not Available

2014-04-01

373

Disorders of sterol synthesis: beyond Smith-Lemli-Opitz syndrome.  

PubMed

Since the discovery in 1993 that Smith-Lemli-Opitz syndrome (SLOS) is a disorder of cholesterol biosynthesis, human disorders associated with additional enzymes involved in the conversion of lanosterol to cholesterol have been identified. This review will focus primarily on the clinical aspects of these disorders, highlighting newly described syndromes, such as SC4MOL deficiency and CK syndrome. We will also provide clinical descriptions of additional cases for extremely rare disorders, such as desmosterolosis. We will compare and contrast the findings with those found in SLOS and briefly discuss possible mechanisms of disease pathogenesis. PMID:23042573

Herman, Gail E; Kratz, Lisa

2012-11-15

374

Medicine in old Fort Smith: struggles with mud and quacks.  

PubMed

Dr. J. G. Eberle's efforts to pave the streets of Fort Smith are illustrative of the challenges facing Arkansas in the nineteenth century. Development of sewers, drains, and a safe water supply helped control epidemics of malaria, yellow fever, cholera, and other forms of dysentery. During this time the medical profession struggled to establish professional standards before the great reforms of medical education took hold in the twentieth century. The military hospital of the Civil War was a precursor of the role hospitals would play in bringing higher standards of care to their communities. PMID:24494351

Prewitt, Taylor

2013-12-01

375

STS-110 M.S. Smith suits up for TCDT  

NASA Technical Reports Server (NTRS)

KENNEDY SPACE CENTER, FLA. -- STS-110 Mission Specialist Steven Smith relaxes during suit fit, which is part of Terminal Countdown Demonstration Test activities. The TCDT is held at KSC prior to each Space Shuttle flight to provide flight crews an opportunity to participate in simulated launch countdown activities. Scheduled for launch April 4, the 11-day mission will feature Shuttle Atlantis docking with the International Space Station (ISS) and delivering the S0 truss, the centerpiece-segment of the primary truss structure that will eventually extend over 300 feet.

2002-01-01

376

[Smith-Magenis syndrome: case report and review].  

PubMed

Smith-Magenis syndrome (SMS) is characterized by distinctive facial features that progress with age, developmental delay, cognitive impairment, and behavioral abnormalities associated with molecular anomaly in 17p11.2. Treatment includes: early childhood intervention programs, special education, vocational training later in life, and speech/language, physical, and occupational, behavioral, and sensory integration therapies. We report a 14-year-old girl with mental retardation, behavioral abnormalities and facial dysmorphism, with SMS diagnosis confirmed by cytogenetic analysis and in situ hydridization (FISH). PMID:18661040

Bronberg, Rubén; Ziembar, María; Drut, Mónica; Goldschmidt, Ernesto

2008-04-01

377

STS-103 Mission Specialist Smith suits up before launch  

NASA Technical Reports Server (NTRS)

After donning his launch and entry suit, sts-103 Mission Specialist Steven L. Smith shows a positive attitude over the second launch attempt for Space Shuttle Discovery. The previous launch attempt on Dec. 17 was scrubbed about 8:52 p.m. due to numerous violations of weather launch commit criteria at KSC. Smith and other crew members Commander Curtis L. Brown Jr., Pilot Scott J. Kelly and Mission Specialists C. Michael Foale (Ph.D.), John M. Grunsfeld (Ph.D.), Claude Nicollier of Switzerland and Jean-Francois Clervoy of France are scheduled to lift off at 7:50 p.m. EST Dec. 19 on mission STS-103, servicing the Hubble Space Telescope. Objectives for the nearly eight-day mission include replacing gyroscopes and an old computer, installing another solid state recorder, and replacing damaged insulation in the telescope. Discovery is expected to land at KSC Monday, Dec. 27, at about 5:24 p.m. EST.

1999-01-01

378

Date & Time: Thursday, May 3, 2012; 14pm Location: Smith Family Room, Dana 1620  

E-print Network

Open House Date & Time: Thursday, May 3, 2012; 1­4pm Location: Smith Family Room, Dana 1620 Phone and meet the staff; Thursday, May 3rd from 1pm-4pm in the Smith Family Room, Dana 1620. Learn about our

Sliz, Piotr

379

The Control System of Adaptive Smith Estimating Pre-Compensation on Chloroacetic Acid Preheating Water Temperature  

Microsoft Academic Search

A plan of adaptive Smith PID estimating pre-compensation control based on a routine Smith predictor is raised to focus on the pure time delay of the preheating water temperature control system and the changing properties of the controlled object in the chloroacetic acid crystallization process. The application proves that this method can well solve the delay of preheating water temperature

Zeng Mingru; Zhai Liguo; Wang Li

2009-01-01

380

2. VIEW OF THE SMITH NO.3 SITE ARE TO THE ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. VIEW OF THE SMITH NO.3 SITE ARE TO THE NORTHEAST. THE BLACKSMITH/MINE CAR REPAIR SHOP IS LEFT CENTER. THE PROCESSING PLANT AND TIPPLE ARE RIGHT CENTER. - Smith Mine, Bear Creek 1.5 miles West of Town of Bear Creek, Red Lodge, Carbon County, MT

381

78 FR 15747 - Charlissa C. Smith (Denial of Senior Reactor Operator License)  

Federal Register 2010, 2011, 2012, 2013, 2014

...55-23694-SP; ASLBP No. 13-925-01-SP-BD01] Charlissa C. Smith (Denial of Senior Reactor Operator License) Notice of Atomic...Licensing Board (Board) in the above-captioned Charlissa C. Smith case is hereby reconstituted because Administrative Judge...

2013-03-12

382

VIEW OF H.M. CAMP SMITH RECREATIONAL AREA, WITH MANANA HOUSING ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

VIEW OF H.M. CAMP SMITH RECREATIONAL AREA, WITH MANANA HOUSING AREA IN THE FAR LEFT DISTANCE. VIEW FACING EAST - Camp H.M. Smith and Navy Public Works Center Manana Title VII (Capehart) Housing, Intersection of Acacia Road and Brich Circle, Pearl City, Honolulu County, HI

383

On Computing the Determinant and Smith Form of an Integer Matrix Wayne Eberly  

E-print Network

On Computing the Determinant and Smith Form of an Integer Matrix Wayne Eberly #3; Department by computing the Smith form of the integer matrix, an extremely useful canonical form in itself. Our algorithm, November 2000. bit operations using standard matrix arithmetic, where kAk = max i j jA i j j . Since

Villard, Gilles

384

Beyond Sweetgrass: The Life and Art of Jaune Quick-to-See Smith  

E-print Network

This dissertation is a brief monographic study of noted American Indian artist-Jaune Quick-to-See Smith. No such study of Smith has been completed to date. This particular study is different because it consists of a Native woman looking at another...

Murphy, Joni Lisa

2008-10-27

385

Raptor: Sketching Games with a Tabletop Computer J. David Smith and T. C. Nicholas Graham  

E-print Network

traditional PC-based tool. Keywords End-User Development, Video Games, Sketching, Tabletop, ComputerRaptor: Sketching Games with a Tabletop Computer J. David Smith and T. C. Nicholas Graham School of Computing Queen's University Kingston, Ontario, Canada {smith, graham} @cs.queensu.ca ABSTRACT Game

Abolmaesumi, Purang

386

CYCLIC MAPS IN RATIONAL HOMOTOPY THEORY GREGORY LUPTON AND SAMUEL BRUCE SMITH  

E-print Network

CYCLIC MAPS IN RATIONAL HOMOTOPY THEORY GREGORY LUPTON AND SAMUEL BRUCE SMITH Abstract. The notion, minimal models. 1 #12;2 GREGORY LUPTON AND SAMUEL BRUCE SMITH Theorem 1.1 ([Got69, Th.4.1,Th.5.1]). Let X

Smith, Sam

387

An Alternative View of the Instructional Design Process: A Response to Smith and Boling  

ERIC Educational Resources Information Center

A recent literature review by Smith and Boling (2009) critically examines the received view of instructional design in educational technology. Smith and Boling conclude that the foundational literature characterizes design in a way that leads to a constrained understanding of design, especially by novices. They suggest that as a field we move…

Gibbons, Andrew S.; Yanchar, Stephen C.

2010-01-01

388

Dyadic Power Theory, Touch, and Counseling Psychology: A Response to Smith, Vogel, Madon, and Edwards (2011)  

ERIC Educational Resources Information Center

Smith, Vogel, Madon, and Edwards' (2011) recent article tested dyadic power theory (DPT) by examining the use of touch as a compliance-gaining tactic in the conflicts of married couples. In this response, we raise a methodological issue about the touch behaviors examined by Smith et al. and also pose a theoretical critique that their test of DPT…

Dunbar, Norah E.; Abra, Gordon

2012-01-01

389

Unconscious Odour Conditioning 25 Years Later: Revisiting and Extending "Kirk-Smith, Van Toller and Dodd"  

ERIC Educational Resources Information Center

The pioneering work by Kirk-Smith, Van Toller, and Dodd [Kirk-Smith, M. D., Van Toller, C., & Dodd, G. H. (1983). "Unconscious odour conditioning in human subjects." "Biological Psychology," 17, 221-231], established that an unnoticed odorant paired with an emotionally meaningful task can influence mood and attitudes when the odorant alone is…

Zucco, Gesualdo M.; Paolini, Michela; Schaal, Benoist

2009-01-01

390

Speech/Language Pathologists Reflect on Sally Smith and the Lab School of Washington  

ERIC Educational Resources Information Center

Sally L. Smith had a clear vision of how she thought speech and language services should be integrated into her school, The Lab School of Washington. It was Smith's idea that language therapists should work individually with students to help them make gains in their particular areas of need, as well as to work collaboratively with the teachers,…

Learning Disabilities: A Multidisciplinary Journal, 2010

2010-01-01

391

The Behavioural Phenotype of Smith-Magenis Syndrome: Evidence for a Gene-Environment Interaction  

ERIC Educational Resources Information Center

Background: Behaviour problems and a preference for adult contact are reported to be prominent in the phenotype of Smith-Magenis syndrome. In this study we examined the relationship between social interactions and self-injurious and aggressive/disruptive behaviour in Smith-Magenis syndrome to explore potential operant reinforcement of problem…

Taylor, L.; Oliver, C.

2008-01-01

392

ADAM SMITH AND THE ROLE OF THE METAPHOR OF AN INVISIBLE HAND  

Microsoft Academic Search

Daniel Klein and Brandon Lucas's In a Word or Two, Placed in the Middle: The Invisible Hand in Smith's Tomes, following a vague hint by Peter Minowitz (2004), offers original physical evidence that Smith deliberately placed the phrase led by an invisible hand- at the physical centre of both his masterworks. Further, it suggests that the invisible-hand paragraphs are a

Gavin Kennedy

2011-01-01

393

Adam Smith's Answer to the Feldstein-Horioka Paradox: The Invisible Hand Revisited  

Microsoft Academic Search

In this paper, we show that Adam Smith pointed out the existence of the Feldstein-Horioka Paradox or Puzzle and even gave an explanation for it morethan 200 years before the publication of Feldstein and Horioka (1980). Smith argues that it is the pursuit of their own security that leads owners of capital to invest their capital in their own country

Ayumu Yasutomi; Charles Yuji Horioka

2010-01-01

394

REGRAS E ORDEM DO MERCADO NAS VISÕES DE ADAM SMITH E F. A. HAYEK  

Microsoft Academic Search

The main objective of this article is to recover, from a critical-philosophical point of view, the central importance of the rules to construct an explanation of the market social order in Adam Smith's and F.A. Hayek's perspectives. We start from a point of view that considers a unifying approach of Adam Smith's work giving to the moral rules the status

Angela Ganem

2005-01-01

395

A CRITICAL REVIEW OF LISA HILL'S VIEW OF ADAM SMITH'S 'HIDDEN THEOLOGY'  

Microsoft Academic Search

Lisa Hill has recently provided a new assessment of Adam Smith which attempts to reveal the 'hidden' theology which underpins his providential or 'optimistic' system of thought. Her interpretation breaks with the mainstream view of Smith as a follower of the secular, or atheistic, David Hume. While Hill concedes that there are resemblances to modern theories of evolution and spontaneous

James E. Alvey

2004-01-01

396

Smith et al. Patterns of diversification in Yucca Electronic Supplementary Material Electronic Supplementary Materials  

E-print Network

Smith et al. Patterns of diversification in Yucca Electronic Supplementary Material Electronic penalty = 15 and a gap extension penalty = 6.66. Phylogenetic analysis- Aligned sequences were as ordered, multi-state characters. #12;Smith et al. Patterns of diversification in Yucca Electronic

Althoff, David M.

397

ELECTRON BUNCH PROFILE DIAGNOSTICS IN THE FEW FS REGIME USING COHERENT SMITH-PURCELL RADIATION  

E-print Network

ELECTRON BUNCH PROFILE DIAGNOSTICS IN THE FEW FS REGIME USING COHERENT SMITH-PURCELL RADIATION R John Adams Institute, University of Oxford, UK, 2 Diamond Light Source, Oxfordshire, UK, 3 SLAC, Menlo. The use of a radiative process such as Smith-Purcell radiation (SPR), is particularly promising

Paris-Sud XI, Université de

398

Aerospace EngineeringSmith and Valasek 1 Agility M etric R obustness  

E-print Network

Aerospace EngineeringSmith and Valasek 1 Agility M etric R obustness U sing LinearErrorTheory David Conference Portland, OR 9 August 1999 #12;Aerospace EngineeringSmith and Valasek 2 O V ER V IEW AGILITY METRICS RESEARCH OBJECTIVES LINEAR ERROR THEORY PROCEDURE SELECTED AGILITY METRICS UCAV 6 AIRCRAFT METRIC

Valasek, John

399

THE HAPPY MARRIAGE: THE INFLUENCE OF CHARLOTTE SMITH ON JANE AUSTEN  

Microsoft Academic Search

All of Jane Austen's fiction shows the repeated influence of Charlotte Smith's nine novels. In the Juvenilia Jane Austen openly exploited Charlotte Smith's Emmeline and Ethelinde more closely than she was ever to use any other novels, referring to them as the prototype of popular current literature. Although Frank W. Bradbrook has noted a few verbal echoes of Emmeline and

WILLIAM H. MAGEE

1975-01-01

400

Is Justice the Primary Feature of the State? Adam Smith's Critique of Social Contract Theory  

Microsoft Academic Search

In light of the question of whether justice is the differentia specifica of the state, this paper reviews Smith's views on justice and social contract theory. The paper finds that Smith did not regard justice, what supposedly motivates agents to enter into a social contract with the sovereign, as the core of the polity. He rather explicitly criticized social contract

ELIAS L. KHALIL

1998-01-01

401

Reconsidering the Teacher Education Reform Debate: A Commentary on Cochran-Smith and Fries  

Microsoft Academic Search

In the November 2001 issue of Educational Researcher, Marilyn Cochran-Smith and Mary Kim Fries provided a penetrating analysis of the discourse that comprises the debate between those who advocate highly professionalized teacher preparation and those who seek simpler and more abundant routes to teacher training and certification. This commentary extends the Cochran-Smith and Fries analysis in several directions, inquiring into

Gary D Fenstermacher

2002-01-01

402

Lee Smith's Fair and Tender Ladies: the female espistolary novel and the construction of knowledge  

E-print Network

This thesis focuses on how Lee Smith, a North Carolina writer, uses the traditional female epistolary form in a revolutionary way in her 1988 novel Fair and Tender Ladies. Smith's use of the form is revolutionary because, as many critics have...

Grubbs, Amy Marie

1994-01-01

403

Research Management Board Meeting 13 November 2002 at NRS Present: Dr P Freer-Smith  

E-print Network

Management ­ Experimental Database, the Chair of this Committee is answerable to the RMB and acts with its1 Research Management Board Meeting ­ 13 November 2002 at NRS Present: Dr P Freer-Smith Mr W Mason of the RMB.Action: SS 14. The Chair (Steve Smith) will be FR's representative on the FC GIS Managing Group

404

The nature of social preference and interactions in Smith-Magenis syndrome.  

PubMed

This natural observation study was designed to evaluate hypothesized elevated 'attention-seeking' and preference for adult attention in Smith-Magenis syndrome. Ten children with Smith-Magenis syndrome were observed across one school day, together with an age matched sample of 10 children with Down syndrome. Levels of attention given to, and vigilance for, adults and peers were recorded and compared. Sequences of behaviour were analyzed to evaluate the temporal relationships between giving and receiving attention during adult-child interactions. Compared to children with Down syndrome, children with Smith-Magenis syndrome gave preferential attention to adults and looked towards adults significantly more than they looked towards peers. Sequential analyses revealed that while children with Smith-Magenis syndrome did not initiate interactions with adults more than children with Down syndrome did, reciprocity between child and adult social behaviours in Smith-Magenis syndrome within interactions was compromised. This less synchronous sequence of child and adult interactions in Smith-Magenis syndrome may be the result of children with Smith-Magenis syndrome attempting to initiate interaction at times when it is unavailable. The marked preference for interacting with adults over peers in Smith-Magenis syndrome indicates atypicality of social interaction in this syndrome. PMID:24120292

Wilde, Lucy; Silva, Daniel; Oliver, Chris

2013-12-01

405

Response to "Ethanol Production and Gasoline Prices: A Spurious Correlation" by Knittel and Smith  

E-print Network

Response to "Ethanol Production and Gasoline Prices: A Spurious Correlation" by Knittel and Smith Beardshear Hall, (515) 294-7612." #12;1 Response to "Ethanol Production and Gasoline Prices: A Spurious and Aaron Smith attack the paper "The Impact of Ethanol Production on US and Regional Gasoline Markets

Rothman, Daniel

406

How To Survive in Postindustrial Environments: Adam Smith's Advice for Today's Colleges and Universities.  

ERIC Educational Resources Information Center

Adam Smith's discussion of the payment modes of teachers and resulting consequences for the quality of teaching and process of curricular innovation are reviewed through the conceptual lens of modern agency theory. Smith's analysis of higher education in his day (eighteenth century) sheds light on faculty incentive and assessment problems that…

Ortmann, Andreas

1997-01-01

407

Rhetorical Studies: A Reassessment of Adam Smith's Lectures on Rhetoric and Belles Lettres.  

ERIC Educational Resources Information Center

Offers a dissenting interpretation of Adam Smith's Lectures on Rhetoric and Belles Lettres and a more conservative perspective on Smith's significance to the history of rhetorical theory. Views the lectures as an historical commentary on literature and rhetoric from the perspective of an eighteenth-century lecturer. (JD)

Purcell, William M.

1986-01-01

408

British Models of Colonial Governance: Adam Smith and John Bruce on the Cape Colony  

Microsoft Academic Search

:The Scottish Enlightenment models of colonial governance produced for the Cape Colony by Adam Smith (1723-1790) and John Bruce (1744-1826) are examined. The article ranges between Smith and Bruce's views on Britain's colonial policy in general terms, and the specifics of their ideas on the Cape Colony. The comparison focuses on three aspects: one, how in political terms the relation

David Johnson

2010-01-01

409

LA LEGITIMITE DU MANAGEMENT PUBLIC : L'APPORT DE LA LECTURE D'ADAM SMITH  

Microsoft Academic Search

The Public Management legitimacy: the contribution of the Adam Smith reading Abstract: This paper brings light on a recurring debate concerning the legitimacy of the existence of the Public Management discipline. Can we recognize some characteristics specific to public organizations, or is there no essential division of nature between public and private? Adam Smith (1723-1790), Scottish philosopher is known for

Régis Martineau

410

British Models of Colonial Governance: Adam Smith and John Bruce on the Cape Colony  

Microsoft Academic Search

The Scottish Enlightenment models of colonial governance produced for the Cape Colony by Adam Smith (1723-1790) and John Bruce (1744-1826) are examined. The article ranges between Smith and Bruce's views on Britain's colonial policy in general terms, and the specifics of their ideas on the Cape Colony. The comparison focuses on three aspects: one, how in political terms the relation

David Johnson

2010-01-01

411

78 FR 6173 - Diana Del Grosso, Ray Smith, Joseph Hatch, Cheryl Hatch, Kathleen Kelley, Andrew Wilklund, and...  

Federal Register 2010, 2011, 2012, 2013, 2014

...Transportation Board [Docket No. FD 35652] Diana Del Grosso, Ray Smith, Joseph Hatch, Cheryl Hatch, Kathleen Kelley, Andrew Wilklund...petition filed on August 1, 2012, by Diana Del Grosso, Ray Smith, Joseph Hatch, Cheryl Hatch, Kathleen Kelley, Andrew...

2013-01-29

412

THE USE OF RADIAL VELOCITY DERIVATIVE TO DIAGNOSE ROTATION AND DIVERGENCE Travis M. Smith1,2, *  

E-print Network

P5.6 THE USE OF RADIAL VELOCITY DERIVATIVE TO DIAGNOSE ROTATION AND DIVERGENCE Travis M. Smith1 was implemented in NSSL's Damaging Downburst Prediction and Detection Algorithm (Smith et al. 2004) for detecting

Smith, Travis

413

Irish Astr. J., 27(1), XXXX, (2000) M. D. SMITH EVOLUTIONARY SCHEMES FOR PROTOSTARS, PROTO BROWN DWARFS  

E-print Network

Irish Astr. J., 27(1), XXXX, (2000) M. D. SMITH EVOLUTIONARY SCHEMES FOR PROTOSTARS, PROTO BROWN DWARFS AND THEIR ENVIRONMENTS M. D. SMITH Armagh Observatory, College Hill, Armagh, N. Ireland, BT61 9DG

414

* Camera connections in Comm. Ctr and all digital equipment *Officers Currently in the FTO Program : Cody Smith  

E-print Network

: Cody Smith UPD Staff as of 9.5.13 Associate Director University Police Major Levelle 63 Assistant Graves 22 Officer Currie 68 Officer Smith 15 Officer Olivo Officer Mills Divisional Campuses Assistant

Mohaghegh, Shahab

415

Obituary: Harding Eugene (Gene) Smith, Jr., 1947-2007  

NASA Astrophysics Data System (ADS)

Harding Eugene Smith Junior, or Gene, as he was known to family, friends, and colleagues, passed away after an automobile accident in Encinitas, California, on 16 August 2007. He was 60 years old. Gene had recently retired from UCSD after thirty years of service. A memorial service was held at Quail Botanical Gardens in Encinitas, California, on 23 August 2007. A web page is dedicated to his memory at http://harding.smith.muchloved.com, where contributions of memories are invited. Gene was born in San Jose, California in 1947, to Harding Eugene Smith Senior, and Bernice Smith (nee Smith). Harding Smith Senior was an air-force navigator; therefore Gene spent his childhood moving from one air-force base to another. Although an only child, Gene was very close to his cousin Meg, whom he lived nearby to in Gilroy for a time, and the two were like brother and sister. The elder Harding Smith was lost in action over Cambodia in the mid-sixties. Gene was a dedicated student, a boy scout, and a Presidential Scholar. He majored in Physics at Caltech, where he also took a lively interest in the football team and the Glee Club, and was elected a House Officer. To his close friends, he was known at Caltech as Smitty, and the closest of them was Rob Drew, who gave a glimpse into that period of Gene's life at the memorial: "Gene arrived early at campus his first year, in response to an invitation to join the football team. Gene's size and features reminded the head coach of a long-forgotten player named 'Johnson.' After a few days of confusion, Gene simply replaced the name on his helmet. 'Johnson!' coach would yell, 'get in there!' If Johnson was going to get to play, Gene was going to be the best Johnson available!" Gene spent the summer of 1966 working at Kitt Peak, where his lifetime love of observing with ground-based telescopes began, though he learned some things the hard way, such as the fact that trying to squeeze 40,000 numbers onto a computer that stored only 32,000 resulted in blown fuses. In a final letter of that summer back to Drew he wrote: "My summer is now complete. I have achieved the highest pinnacle in my quest for fulfillment. Striking a blow for humanity I just blew the whole Kitt Peak CDC3200 computer system. Those fuses were nothing compared to this!" Gene's graduate work, on the metal abundances in HII regions of nearby galaxies, was done at Berkeley, where Hyron Spinrad was his thesis advisor. He loved observing and spent numerous fun nights at Lick, Kitt Peak, Cerro Tololo, Keck, and many other observatories. He joined Margaret Burbidge at UCSD for a postdoctoral fellowship, and joined the teaching faculty there in 1978. Gene spent his entire professional career at UCSD. His research ranged from the study of quasar absorptions lines to the astrophysics of Ultra-luminous Infrared Galaxies. He was a key participant in UC-wide astronomy support, including being the chair of the science-advisory committee for the Ten Meter Telescope project, which later "morphed" into the Keck Observatory. His contributions to enabling that project were both essential and unheralded. Gene was a dedicated and enthusiastic teacher. One of his favorite undergraduate classes gave him the opportunity to dress up in Renaissance garb and pretend to be Galileo, while the experiment most loved by his students was when they got to attempt to drop an egg on his head from several stories high. Gene was also an outstanding advisor and mentor, and both his first post-doc, Rick Puetter, and his last graduate student, Brian Siana, were able to attend his memorial service and provide some special memories of their experiences with him. Rick recalled a memorable trip to Cerro Tololo when they packed up two infrared spectrometers for the trip, and everything conceivable went wrong, from inspections at the airport to spectrometer parts broken on the plane and instrument failures at the observatory, to finally being completely clouded out. Brian recounted: "I spent countless cloudy nights listening to Gene's stories

Lonsdale, Carol; Soifer, Tom

2009-01-01

416

Allelic Variation in Malawi Cichlid Opsins: A Tale of Two Genera Adam R. Smith Karen L. Carleton  

E-print Network

Allelic Variation in Malawi Cichlid Opsins: A Tale of Two Genera Adam R. Smith · Karen L. Carleton speciation (Kornfield and Smith 2000; Danley and Kocher 2001; Gen- ner and Turner 2005). Lakes Malawi00239-010-9355-x) contains supplementary material, which is available to authorized users. A. R. Smith

Carleton, Karen L.

417

ASRF Visiting Senior Research Fellow Scheme The Adam Smith Research Foundation, based in the College of Social Sciences at the  

E-print Network

1 ASRF Visiting Senior Research Fellow Scheme The Adam Smith Research Foundation, based in the College of Social Sciences at the University of Glasgow, brings the Enlightenment legacy of Adam Smith these aims the Adam Smith Research Foundation invites applications for VISITING SENIOR RESEARCH FELLOWS

Guo, Zaoyang

418

The Adventures of Captain John Smith, Pocahontas and a Sundial: Cosmology, Mathematics, and Power at the Time of Jamestown  

Microsoft Academic Search

While exploring the Chickahominy River in Virginia by canoe in December 1607, Captain John Smith was ambushed by 200 Powhatan Indians and chased into the swamp. Wounded by arrows and mired in the cold mud, Smith surrendered and was led to their chieftain, Opechancanough. Smith played for time. He pulled out his pocket sundial and proceeded to deliver a lecture

Sara J. Schechner

2007-01-01

419

75 FR 68401 - Duncan Smith and Gerald Altizer-Continuance in Control Exemption-Eighteen Thirty Group, LLC and...  

Federal Register 2010, 2011, 2012, 2013, 2014

...Transportation Board [Docket No. FD 35436] Duncan Smith and Gerald Altizer--Continuance in Control...and Georges Creek Railway, LLC Duncan Smith and Gerald Altizer (collectively applicants...becoming Class III rail carriers. Mr. Smith owns 80% of Eighteen Thirty and 75%...

2010-11-05

420

77 FR 30047 - Notice of Opportunity for Public Comment on Surplus Property Release at Michael J Smith Field...  

Federal Register 2010, 2011, 2012, 2013, 2014

...on Surplus Property Release at Michael J Smith Field, Beaufort, NC AGENCY: Federal...airport property, located at the Michael J Smith Field, be used for aeronautical purposes...acres of airport property at the Michael J Smith Field. The property consists of one...

2012-05-21

421

Discovery and early development of squaraine rotaxanes Jeremiah J. Gassensmith, Jeffrey M. Baumes and Bradley D. Smith*  

E-print Network

and Bradley D. Smith* Received (in Cambridge, UK) 5th June 2009, Accepted 17th July 2009 First published macrocycle.7 A few months later a new postdoctoral associate, Dr Easwaran Arunkumar, started in the Smith, 46556, USA. E-mail: smith.115@nd.edu; Fax: +1 5746316652; Tel: +1 5746318632 Jeremiah J. Gassensmith

Smith, Bradley D.

422

GOESR Applications for the Assessment of Aviation Hazards Wayne Feltz, John Mecikalski, Mike Pavolonis, Kenneth Pryor, and Bill Smith  

E-print Network

GOES­R Applications for the Assessment of Aviation Hazards Wayne Feltz, John Mecikalski, Mike Pavolonis, Kenneth Pryor, and Bill Smith 7. FOG AND LOW CLOUDS William L. Smith Jr., Climate Science Branch (E302), NASA Langley Research Center, MS 420 B1250 Rm 165 Hampton, VA. 23681-2199 E-mail: william.l.smith

Kuligowski, Bob

423

76 FR 59115 - Notice of Availability of Patent Fee Changes Under the Leahy-Smith America Invents Act  

Federal Register 2010, 2011, 2012, 2013, 2014

...Patent Fee Changes Under the Leahy- Smith America Invents Act AGENCY: United States Patent...date of enactment of the Leahy-Smith America Invents Act (i.e., September 26...date of enactment of the Leahy-Smith America Invents Act (i.e., November...

2011-09-23

424

77 FR 442 - Changes To Implement Miscellaneous Post Patent Provisions of the Leahy-Smith America Invents Act  

Federal Register 2010, 2011, 2012, 2013, 2014

...Patent Provisions of the Leahy-Smith America Invents Act AGENCY: United States Patent...SUMMARY: The Leahy-Smith America Invents Act expands the scope of information...post grant review. The Leahy-Smith America Invents Act also provides for an...

2012-01-05

425

77 FR 46615 - Changes To Implement Miscellaneous Post Patent Provisions of the Leahy-Smith America Invents Act  

Federal Register 2010, 2011, 2012, 2013, 2014

...Patent Provisions of the Leahy-Smith America Invents Act AGENCY: United States Patent...SUMMARY: The Leahy-Smith America Invents Act (AIA) expands the scope...Patent Provisions of the Leahy-Smith America Invents Act, 77 FR 442 (Jan. 5,...

2012-08-06

426

Mutational spectrum of Smith-Lemli-Opitz syndrome.  

PubMed

Smith-Lemli-Opitz syndrome (SLOS; OMIM #270400) is an autosomal recessive malformation syndrome characterized by a large spectrum of morphogenic and congenital anomalies. SLOS is caused by mutations in the DHCR7 gene, which encodes 7-dehydrocholesterol reductase, the enzyme that catalyzes the final step in cholesterol biosynthesis. We report on 154 currently known mutations in DHCR7 identified in patients affected with SLOS and discuss their coding consequences. These 154 mutations include 130 missense, 8 nonsense, 8 deletions, 2 insertions, 1 indel, and 5 splice site mutations. Using information available from published case reports and from patients identified in our clinical diagnostic laboratory, we analyzed correlations between genotype, clinical presentation and 7-dehydrocholesterol level. PMID:23042628

Waterham, Hans R; Hennekam, Raoul C M

2012-11-15

427

Stimulated Terahertz Smith-Purcell Radiation in Planar Gunn Diodes  

NASA Astrophysics Data System (ADS)

We propose a room-temperature semiconductor source of coherent narrowband Smith-Purcell radiation (SPR) in the spectral range of 0.1-1.2 THz. Spontaneous SPR in semiconductors has been observed at low temperature with very low power. Practical vacuum SPR devices utilize a pre-bunched electron beam to achieve the stimulated mode of operation. However, electron bunches quickly dissipate in semiconductors. We propose to utilize the Gunn instability to form stable charge bunches (Gunn domains) that enable semiconductor sources of stimulated SPR. The device is a planar Gunn diode with a thin dielectric spacer layer and metallic grating deposited on the drift region. The SPR frequency is determined by the domain velocity and the grating period. In contrast to conventional Gunn diodes, the frequency is not limited by the transit time. Our calculations show that technologically relevant power density levels (1-100 nW per micrometer of device width) may be achieved by this method.

Belyanin, Alexey; Smith, Don D.

2011-03-01

428

Room-temperature semiconductor coherent Smith-Purcell terahertz sources  

NASA Astrophysics Data System (ADS)

We propose a room-temperature semiconductor source of coherent narrowband Smith-Purcell radiation (SPR) in the low-to-mid terahertz range. The device is a planar Gunn diode with a metallic grating deposited near the drift region. Stimulated SPR is generated as domains move under the grating. Radiation frequency is determined by the domain velocity and grating period—it is not transit-time limited. The approach is photolithographically tunable, readily scales to arrays, and is compatible with any planar Gunn technology. Integration with a planar antenna improves radiation efficiency and enables far-field optimization. We develop an analytic theory of the devices which agrees well with simulations. Results indicate that this method may achieve technologically relevant power density levels and warrants experimental investigation.

Smith, Don D.; Belyanin, Alexey

2011-02-01

429

Special Smith-Purcell radiation from an open resonator array  

NASA Astrophysics Data System (ADS)

An interesting new physical phenomenon is uncovered—an open resonator array excited by an electron beam and able to generate a special kind of Smith-Purcell radiation (SPR). Although the frequency and direction satisfy the SPR relation, this is a single frequency radiation in a specific direction that is essentially different from ordinary SPR. The spectral density of this special radiation is also much higher than that of ordinary SPR. By means of theoretical analysis and digital simulations, the radiation mechanism together with its requirements are explored. This radiation may have great influence in modern physics and optics as it offers new ways to carry out coherent radiation generation and beam diagnostics.

Liu, Weihao; Xu, Zhengyuan

2014-07-01

430

Sophia Smith Collection: Population and Reproductive Health Oral History Project  

NSDL National Science Digital Library

Funded by the William and Flora Hewlett Foundation, the Population and Reproductive Health Oral History Project includes accounts of individuals throughout the world who have made valued contributions to the field. The materials here are part of the Women's History Archives at Smith College and the series includes the voices and perspectives of advocates, communication specialists, lawyers, managers, physicians, researchers, and social workers from the period 1965 to 2005. First-time visitors should read the Project History essay and then take a closer look at the several dozen interviews offered here. Those profiled here include the "mother of Asian demography," Mercedes Concepcion, and Lee Minto, the president of Planned Parenthood of Seattle-King County from 1967 to 1993. Other people interviewed here include Daniel E. Pellegrom, Nafis Sadik, and Sara Seims. It's a wonderful archive for persons interested in public health, women's studies, and a range of other crucial areas of academic study.

2013-05-16

431

The analysis of convolutional codes via the extended Smith algorithm  

NASA Technical Reports Server (NTRS)

Convolutional codes have been the central part of most error-control systems in deep-space communication for many years. Almost all such applications, however, have used the restricted class of (n,1), also known as 'rate 1/n,' convolutional codes. The more general class of (n,k) convolutional codes contains many potentially useful codes, but their algebraic theory is difficult and has proved to be a stumbling block in the evolution of convolutional coding systems. In this article, the situation is improved by describing a set of practical algorithms for computing certain basic things about a convolutional code (among them the degree, the Forney indices, a minimal generator matrix, and a parity-check matrix), which are usually needed before a system using the code can be built. The approach is based on the classic Forney theory for convolutional codes, together with the extended Smith algorithm for polynomial matrices, which is introduced in this article.

Mceliece, R. J.; Onyszchuk, I.

1993-01-01

432

Mission Specialist Smith is suited and ready for launch  

NASA Technical Reports Server (NTRS)

In the Operations and Checkout Building, STS-103 Mission Specialist Steven L. Smith signals he is suited up and ready for launch. Other crew members are Commander Curtis L. Brown Jr., Pilot Scott J. Kelly and Mission Specialists C. Michel Foale (Ph.D.), John M. Grunsfeld (Ph.D.), Jean-Frangois Clervoy of France and Claude Nicollier of Switzerland. Clervoy and Nicollier are with the European Space Agency. The STS-103 mission, to service the Hubble Space Telescope, is scheduled for launch Dec. 17 at 8:47 p.m. EST from Launch Pad 39B. Mission objectives include replacing gyroscopes and an old computer, installing another solid state recorder, and replacing damaged insulation in the telescope. After the 8-day, 21-hour mission, Discovery is expected to land at KSC Sunday, Dec. 26, at about 6:30 p.m. EST.

1999-01-01

433

Periventricular nodular heterotopia in Smith-Magenis syndrome.  

PubMed

Smith-Magenis syndrome (SMS) is caused by an interstitial microdeletion of chromosome 17p11.2. A few patients with the typical SMS phenotype have RAI1 gene mutations. The syndrome is characterized by minor craniofacial anomalies, short stature, sleep disturbances, behavioural and neurocognitive abnormalities, as well as variable multisystemic manifestations. Periventricular nodular heterotopia (PNH) is a genetically heterogeneous neuronal migration disorder characterized by subependymal heterotopic nodules, and is variably associated with other brain malformations, epileptic seizures and intellectual disability. Here we report on two patients harboring deletions of the 17p11.2 region in whom the SMS typical phenotype was associated with bilateral PNH. Our observations expand the spectrum of chromosomal rearrangements associated with PNH and indicate that abnormal neuronal migration may contribute to the neurocognitive phenotype of SMS. PMID:25257626

Capra, Valeria; Biancheri, Roberta; Morana, Giovanni; Striano, Pasquale; Novara, Francesca; Ferrero, Giovanni Battista; Boeri, Luca; Celle, Maria Elena; Mancardi, Maria Margherita; Zuffardi, Orsetta; Parrini, Elena; Guerrini, Renzo

2014-12-01

434

Abilities and attainment in Smith-Magenis syndrome.  

PubMed

This study reports on cognitive abilities and attainment in 29 children and 21 adults with Smith-Magenis syndrome. There were 13 boys and 16 girls aged 6 to 16 years, and nine men and 12 women aged 16 to 52 years. All had mild to severe learning disabilities* with no differences overall between verbal and performance skills, but with a particular profile of cognitive strengths and weaknesses. Levels of attainment and of adaptive behaviour were strikingly low, and the group of adults emerged as much more dependent on carers than might have been expected from their general level of intellectual functioning. Reasons for this discrepancy are explored in terms of the severe behavioural difficulties characteristic of the syndrome. PMID:11769269

Udwin, O; Webber, C; Horn, I

2001-12-01

435

Deaf Smith County air quality analysis: Letter report: Revision 2  

SciTech Connect

Air quality impacts due to site characterization, and repository construction and operation activities were evaluated in the Deaf Smith County Site, Texas environmental assessment (EA). The analyses on which the impact assessments are based made with dispersion models recommended by the EPA for such applications, meteorological data from a nearby representative National Weather Service station at Amarillo, Texas, and available background air quality data from an urban monitoring location. Maximum offsite concentrations of total suspended particulates, nitrogen dioxide, sulfur dioxide, and carbon monoxide were estimated for periods of maximum emissions identified for each pollutant. Estimates of total annual salt deposition resulting from repository salt handling operations were also made. 36 refs., 5 figs., 17 tabs.

Not Available

1985-11-01

436

Deaf Smith County noise analysis: Revision 2. [Contains glossary  

SciTech Connect

An analysis of activities proposed for the three major phases of development of the proposed nuclear waste repository site in Deaf Smith County, Texas, was conducted to quantify the noise levels and the effect of noise resulting from these activities. The report provides additional details of the predictive noise level modeling conducted for the site characterization, repository construction, and repository operation phases. Equivalent day/night sound levels are presented for each phase as sound level contours. Sound levels from onsite and offsite activities are addressed including traffic on access routes, and railroad construction and operation. A description of the predictive models, the analysis methodologies, the noise source inventories, the model outputs, and the evaluation criteria are included. 35 refs., 6 figs., 2 tabs.

Not Available

1985-11-01

437

Analysis of Smith-Purcell free-electron lasers.  

PubMed

We present an analysis of the beam dynamics in a Smith-Purcell free-electron laser (FEL). In this system, an electron beam interacts resonantly with a copropagating surface electromagnetic mode near the grating surface. The surface mode arises as a singularity in the frequency dependence of the reflection matrix. Since the surface mode is confined very close to the grating surface, the interaction is significant only if the electrons are moving very close to the grating surface. The group velocity of the surface mode resonantly interacting with a low-energy electron beam is in the direction opposite to the electron beam. The Smith-Purcell FEL is therefore a backward wave oscillator in which, if the beam current exceeds a certain threshold known as start current, the optical intensity grows to saturation even if no mirrors are employed for feedback. We derive the coupled Maxwell-Lorentz equations for describing the interaction between the surface mode and the electron beam, starting from the slowly varying approximation and the singularity in the reflection matrix. In the linear regime, we derive an analytic expression for the start current and calculate the growth rate of optical power in time. The analysis is extended to the nonlinear regime by performing a one-dimensional time-dependent numerical simulation. Results of our numerical calculation compare well with the analytic calculation in the linear regime and show saturation behavior in the nonlinear regime. We find that a significant amount of power grows in the surface mode due to this interaction. Several ways to outcouple this power to freely propagating modes are discussed. PMID:16605464

Kumar, Vinit; Kim, Kwang-Je

2006-02-01

438

Smith college secondary math and science outreach program  

SciTech Connect

The Smith College Secondary Math and Science Outreach Program works collaboratively with front-line educators to encourage young women students of all abilities, especially underrepresented and underserved minorities, to continue studying math and science throughout high school. The program includes three main components: (1) Twenty-five to thirty teams of math/science teachers and guidance counselors participate in a year-long program which begins with a three-day Current Students/Future Scientists and Engineering Workshop. This event includes a keynote address, presentations and workshops by successful women in science and engineering, and hands-on laboratory sessions. Each participant receives a stipend and free room and board. Returning to their schools, the teacher-counselor teams implement ongoing plans designed to counteract gender bias in the sciences and to alert female students to the broad range of math, science, and engineering career choices open to them. A follow-up session in the spring allows the teams to present and discuss their year-long activities. (2) TRI-ON, a day of science for 120 ninth- and tenth- grade girls from schools with a large underserved and underrepresented population, is held in early spring. Girls discover the excitement of laboratory investigation and interact with female college science and math majors. (3) Teaching Internships, initiated in 1991, involve ten to fifteen Smith College math and science majors in teaching in public schools. The teaching interns experience the rewards and challenges of classroom teaching, and they also serve as role models for younger students.

Powell, J.A.; Clark, C. [Smith College, Northhampton, MA (United States)

1994-12-31

439

The eleventh reported case of Mulvihill-Smith syndrome in the literature  

PubMed Central

Background The Mulvihill-Smith Syndrome was first recognized in 1975. After the recognition of the Mulvihill-Smith Syndrome, ten cases have been described. Case presentation This article describes the eleventh case of this syndrome in a male patient, 24 years-old with short stature and microcephaly with mild cognitive impairment, deafness and allergic conjunctivitis. The patient was hospitalized several times for repeated infections, and the presence of multiple melanocytic nevi on his skin was noticed. Conclusions Based on the entire set of signs and symptoms presented in our study, it was diagnosed the patient with Mulvihill-Smith Syndrome. PMID:24397283

2014-01-01

440

A local construction of the Smith normal form of a matrix polynomial  

SciTech Connect

We present an algorithm for computing a Smith form with multipliers of a regular matrix polynomial over a field. This algorithm differs from previous ones in that it computes a local Smith form for each irreducible factor in the determinant separately and then combines them into a global Smith form, whereas other algorithms apply a sequence of unimodular operations to the original matrix row by row (or column by column). The performance of the algorithm in exact arithmetic is reported for several test cases.

Wilkening, Jon; Yu, Jia

2008-09-01

441

Comments on the "Proof of the atmospheric greenhouse effect" by Arthur B. Smith  

E-print Network

In this paper it is shown that Smith (2008) used inappropriate and inconsistent formulations in averaging various quantities over the entire surface of the Earth considered as a sphere. Using two instances of averaging procedures as customarily applied in studies on turbulence, it is shown that Smith's formulations are highly awkward. Furthermore, Smith's discussion of the infrared absorption in the atmosphere is scrutinized and evaluated. It is shown that his attempt to refute the criticism of Gerlich and Tscheuschner (2007, 2009) on the so-called greenhouse effect is rather fruitless.

Kramm, Gerhard; Zelger, Michael

2009-01-01

442

Adam Smith's rhetorical sympathy: a return of moral sentiments to public policy  

E-print Network

Into the Nature and Causes of the Wealth of Nations. Smith also wrote The Theorv of Moral Sentnnents, which focuses more directly than the Wealth of Nattotrs on how to improve the human condition through thc use of a pnnciple he labeled sympathy. In TMS, Smith... with their fellow citizens. In addition to helping us recognize the needs of others, sympathy can inform public policy. Many have wondered how Smith could go from an altruistic approach to public affairs in TMS, to the more egoistic self-interest of the Wealth...

Gore, David Charles

2001-01-01

443

Matthew B. Weinger, MD Norman Ty Smith Chair in Patient Safety & Medical Simulation  

E-print Network

Matthew B. Weinger, MD Norman Ty Smith Chair in Patient Safety & Medical Simulation Professor in Systems Safety Vanderbilt University Medical Center * and years of designing HIT too! Developing of Anesthesiology, Biomedical Informatics & Medical Education Director, Center for Research and Innovation

444

Astrophysics with Milagro A. J. Smith for the Milagro Collaboration1  

E-print Network

Astrophysics with Milagro A. J. Smith for the Milagro Collaboration1 Dept. of Physics, University Astrophysics with Milagro October 25, 2004 1 #12;from a crab like spectrum is ¡ 3 TeV. The Milagro Gamma Ray

California at Santa Cruz, University of

445

77 FR 51064 - Huntington Foam LLC, Fort Smith, AR; Notice of Affirmative Determination Regarding Application...  

Federal Register 2010, 2011, 2012, 2013, 2014

...DEPARTMENT OF LABOR Employment and Training Administration [TA-W-81,475] Huntington Foam LLC, Fort Smith, AR; Notice of Affirmative Determination Regarding Application for Reconsideration By application dated May 21, 2012,...

2012-08-23

446

Cruise Report R/V F. G. Walton Smith Cruise 0813  

E-print Network

, Engineer Stewart Bell, Mate Jimmy Bovina, Cook William Smith, ABS Dennis Ilias, Marine Technician, RSMAS of fluorescein dye (42.5%) mixed with alcohol and water to give a specific gravity of 1.00, by Abbey Color, Inc

Sundermeyer, Miles A.

447

Evolutionary consequences of dispersal ability in cactus-feeding insects Christopher Irwin Smith1,2,  

E-print Network

Evolutionary consequences of dispersal ability in cactus-feeding insects Christopher Irwin Smith1 and macroevolutionary patterns; this prediction is borne out by comparisons of species diversity in cactus

Farrell, Brian D.

448

MR. smith's descriptions OP HTMENOPTEROUS INSECTS. 57 Descriptions of New Species of Hymenopterous Insects collected  

E-print Network

, and that indigenous to Europe ; the discovery of a second may be regarded as one of the most valuable additions which segment of the abdomea LINN. PHOC--ZOOLOGV, SUPPLEMENT. 5 #12;58 MR. smith's descbiptions

Villemant, Claire

449

The where's and when's of kinase F. Donelson Smith, Lorene K. Langeberg and John D. Scott  

E-print Network

The where's and when's of kinase anchoring F. Donelson Smith, Lorene K. Langeberg and John D. Scott of protein kinase research was born, paving the way for the discovery of phosphotyrosine by Hunter and co

Scott, John D.

450

Constructing and Clearing Combinatorial Exchanges Using Preference Elicitation Trey Smith and Tuomas Sandholm and Reid Simmons  

E-print Network

Constructing and Clearing Combinatorial Exchanges Using Preference Elicitation Trey Smith then decides the task allocation among the agents. Unfortunately, such exchanges can require that bidders exchange using preference elicitation. This design extends existing analyses of elicitation

Simmons, Reid

451

Francis H. Smith: architect of antebellum southern military schools and educational reform  

E-print Network

This study examines the historical significance of the Virginia Military Institute�s (VMI) first superintendent, Francis Henney Smith, and his influence not only at his home institution but also on his broader social, educational, and political...

Wineman, Bradford Alexander

2006-10-30

452

REMOTE SENSING (SUR 4380) Instructor: Scot E. Smith, Professor, Geomatics Program, School of Forest Resources and  

E-print Network

REMOTE SENSING (SUR 4380) Instructor: Scot E. Smith, Professor, Geomatics Program, School of Forest and Sons, 2008. Course website: \\\\ad.ufl.edu\\ifas\\SFRC\\Private\\Geomatics\\Courses Topics: Remote sensing

Watson, Craig A.

453

CUDASW++: optimizing Smith-Waterman sequence database searches for CUDA-enabled graphics processing units  

Microsoft Academic Search

BACKGROUND: The Smith-Waterman algorithm is one of the most widely used tools for searching biological sequence databases due to its high sensitivity. Unfortunately, the Smith-Waterman algorithm is computationally demanding, which is further compounded by the exponential growth of sequence databases. The recent emergence of many-core architectures, and their associated programming interfaces, provides an opportunity to accelerate sequence database searches using

Yongchao Liu; Douglas L Maskell; Bertil Schmidt

2009-01-01

454

Prenatal Diagnosis of Smith-Magenis Syndrome (del 17p11.2)  

Microsoft Academic Search

Smith-Magenis syndrome is associated with a microdeletion of the short arm of chromosome 17 with phenotypic abnormalities including dysmorphic facies, self-injurious behavior, mental and neurologic disturbances, and congenital cardiac defects. The majority of patients present in mid-childhood or adulthood. We describe a fetus in which the diagnosis of Smith-Magenis syndrome was made at 16 weeks of gestation following amniocentesis for

Dafydd G. Thomas; Suzanne M. Jacques; Leigh Anne Flore; Baruch Feldman; Mark I. Evans; Faisal Qureshi

2000-01-01

455

An optimal control approach to pilot/vehicle analysis and Neal-Smith criteria  

NASA Technical Reports Server (NTRS)

The approach of Neal and Smith was merged with the advances in pilot modeling by means of optimal control techniques. While confirming the findings of Neal and Smith, a methodology that explicitly includes the pilot's objective in attitude tracking was developed. More importantly, the method yields the required system bandwidth along with a better pilot model directly applicable to closed-loop analysis of systems in any order.

Bacon, B. J.; Schmidt, D. K.

1984-01-01

456

Measuring short electron bunch lengths using coherent smith-purcell radiation  

DOEpatents

A method is provided for directly determining the length of sub-picosecond electron bunches. A metallic grating is formed with a groove spacing greater than a length expected for the electron bunches. The electron bunches are passed over the metallic grating to generate coherent and incoherent Smith-Purcell radiation. The angular distribution of the coherent Smith-Purcell radiation is then mapped to directly deduce the length of the electron bunches.

Nguyen, Dinh C. (Los Alamos, NM)

1999-01-01

457

The Futility of Utility: how market dynamics marginalize Adam Smith  

E-print Network

Econometrics is based on the nonempiric notion of utility. Prices, dynamics, and market equilibria are supposed to be derived from utility. Utility is usually treated by economists as a price potential, other times utility rates are treated as Lagrangians. Assumptions of integrability of Lagrangians and dynamics are implicitly and uncritically made. In particular, economists assume that price is the gradient of utility in equilibrium, but I show that price as the gradient of utility is an integrability condition for the Hamiltonian dynamics of an optimization problem in econometric control theory. One consequence is that, in a nonintegrable dynamical system, price cannot be expressed as a function of demand or supply variables. Another consequence is that utility maximization does not describe equiulibrium. I point out that the maximization of Gibbs entropy would describe equilibrium, if equilibrium could be achieved, but equilibrium does not describe real markets. To emphasize the inconsistency of the economists' notion of 'equilibrium', I discuss both deterministic and stochastic dynamics of excess demand and observe that Adam Smith's stabilizing hand is not to be found either in deterministic or stochastic dynamical models of markets, nor in the observed motions of asset prices. Evidence for stability of prices of assets in free markets simply has not been found.

Joseph L. McCauley

2000-02-02

458

Cognitive and behavioral aspects of Smith-Lemli-Opitz syndrome.  

PubMed

The brain's high concentrations of cholesterol make it especially vulnerable to the cholesterol biosynthetic defect that characterizes Smith-Lemli-Opitz syndrome (SLOS). An attempt to characterize the cognitive and behavioral phenotype of SLOS has identified increased rates of intellectual disability, language and motor developmental delay, repeated self-injury behaviors, sensory hyperreactivity, hyperactivity, affect dysregulation, and sleep disturbances. Some research has suggested that carriers of the gene mutation that results in SLOS display increased risk of suicidal behavior. Cholesterol dysregulation impairs neuroplasticity, which may be a mechanism underlying some of the mentioned abnormalities. Discrete positive effects have been reported with the use of cholesterol supplementation in the treatment of SLOS. Research has been limited by the small number of subjects available, and a limited understanding of lipid metabolism in the brain. Hopefully future research will help clarify the role that cholesterol plays in cognitive and behavioral abnormalities like the ones associated with SLOS. This would accelerate the development of treatments for SLOS, and perhaps also further understanding of non-syndromic psychiatric disorders such as autism and attention deficit hyperactivity disorder. PMID:23042585

Diaz-Stransky, Andrea; Tierney, Elaine

2012-11-15

459

Smith-Lemli-Opitz syndrome: phenotype, natural history, and epidemiology.  

PubMed

Smith-Lemli-Opitz syndrome (SLOS) is a congenital multiple anomaly/intellectual disability syndrome caused by a deficiency of cholesterol synthesis resulting from a deficiency of 7-dehydrocholesterol (7DHC) reductase encoded by DHCR7. SLOS is inherited in an autosomal recessive pattern. It is characterized by prenatal and postnatal growth retardation, microcephaly, a variable degree of intellectual disability that encompasses normal intelligence to severe intellectual deficiency, and multiple major and minor malformations. External malformations include distinctive facial features, cleft palate, postaxial polydactyly, 2-3 syndactyly of the toes, and underdeveloped external genitalia in males, while internal anomalies may affect every organ system. The clinical spectrum is wide, and rare individuals have been described with normal development and only minor malformations. The clinical diagnosis of SLOS is confirmed by demonstrating an abnormally elevated concentration of the cholesterol precursor, 7DHC, in serum or other tissues, or by the presence of two DHCR7 mutations. The enzymatic deficiency results in decreased cholesterol and increased 7DHC levels, both during embryonic development and after birth. The malformations found in SLOS may result from decreased cholesterol, increased 7DHC or a combination of these two factors. This review discusses the physical and behavioral phenotype of SLOS, the diagnostic approaches, the natural history from the prenatal period to adulthood, and current understanding of the pathophysiology of SLOS. PMID:23059950

Nowaczyk, Ma?gorzata J M; Irons, Mira B

2012-11-15

460

Peroxisomal cholesterol biosynthesis and Smith-Lemli-Opitz syndrome  

SciTech Connect

Smith-Lemli-Opitz syndrome (SLOS), caused by 7-dehydrocholesterol-reductase (DHCR7) deficiency, shows variable severity independent of DHCR7 genotype. To test whether peroxisomes are involved in alternative cholesterol synthesis, we used [1-{sup 14}C]C24:0 for peroxisomal {beta}-oxidation to generate [1-{sup 14}C]acetyl-CoA as cholesterol precursor inside peroxisomes. The HMG-CoA reductase inhibitor lovastatin suppressed cholesterol synthesis from [2-{sup 14}C]acetate and [1-{sup 14}C]C8:0 but not from [1-{sup 14}C]C24:0, implicating a peroxisomal, lovastatin-resistant HMG-CoA reductase. In SLOS fibroblasts lacking DHCR7 activity, no cholesterol was formed from [1-{sup 14}C]C24:0-derived [1-{sup 14}C]acetyl-CoA, indicating that the alternative peroxisomal pathway also requires this enzyme. Our results implicate peroxisomes in cholesterol biosynthesis but provide no link to phenotypic variation in SLOS.

Weinhofer, Isabelle [Center for Brain Research, Medical University of Vienna, Vienna (Austria); Kunze, Markus [Center for Brain Research, Medical University of Vienna, Vienna (Austria); Stangl, Herbert [Department of Medical Chemistry, Medical University of Vienna, Vienna (Austria); Porter, Forbes D. [National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD (United States); Berger, Johannes [Center for Brain Research, Medical University of Vienna, Vienna (Austria)]. E-mail: johannes.berger@meduniwien.ac.at

2006-06-23

461

Smith River Rancheria's Development of an Energy Organization Investigation  

SciTech Connect

Smith River Rancheria (SRR), for some time, has had a strong commitment to attaining energy selfsufficiency, to reduce overall energy costs and concurrently initiate economic development within the community. Early on it was recognized that the development of an energy organization was important and for this reason was made part of the SRR's strategic review not only for economic development but also the reduction of energy costs. Towards this end, SRR retained Werner G. Buehler of W.G. Buehler & Associates to investigate the many phases or steps required to establish such an energy organization and determine, if in fact, it could benefit the Tribe. The basic phases are delineated as: (1) Identify potential sources of wholesale power and transmission paths; (2) Evaluating the various forms of energy organizations; (3) Determining the benefits (and disadvantages) of each form of organization; (4) Gathering costs to organize and operate the selected form or energy organization; (5) Performing an economic analysis of forming and operating an energy organization; and (6) Develop an implementation plan.

W.G Buehler & Associates

2007-08-27

462

STS-103 M.S. Steven Smith during TCDT activities  

NASA Technical Reports Server (NTRS)

STS-103 Mission Specialist Steven L. Smith gets ready to practice driving a small armored personnel carrier that is part of emergency egress training during Terminal Countdown Demonstration Test (TCDT) activities. The tracked vehicle could be used by the crew in the event of an emergency at the pad during which the crew must make a quick exit from the area. The TCDT also provides simulated countdown exercises and opportunities to inspect the mission payloads in the orbiter's payload bay. STS-103 is a 'call-up' mission due to the need to replace and repair portions of the Hubble Space Telescope. Although Hubble is operating normally and conducting its scientific observations, only three of its six gyroscopes are working properly. Four EVA's are planned to make the necessary repairs and replacements on the telescope. The other STS-103 crew members are Commander Curtis L. Brown Jr., Pilot Scott J. Kelly, and Mission Specialists John M. Grunsfeld (Ph.D.), C. Michael Foale (Ph.D.), (Ph.D.), and Claude Nicollier of Switzerland and Jean-Frangois Clervoy of France, who are with the European Space Agency. The mission is targeted for launch Dec. 6 at 2:37 a.m. EST.

1999-01-01

463

Smith-Magenis syndrome: clinical evaluation in seven Brazilian patients.  

PubMed

Smith-Magenis syndrome (SMS) is a complex congenital anomaly characterized by craniofacial anomalies, neurological and behavioral disorders. SMS is caused by a deletion in region 17p11.2, which includes the RAI1 gene (90% of cases), or by point mutation in the RAI1 gene (10% of cases). Laboratory diagnosis is through cytogenetic analysis by GTG banding and molecular cytogenetic analysis by FISH. We carried out an active search for patients in Associations of Parents and Friends of Exceptional Children (APAE) of São Paulo and genetic centers in Brazil. Forty-eight patients were screened for mental retardation, craniofacial abnormalities and stereotyped behavior with a diagnosis of SMS. In seven of them, chromosome banding at high resolution demonstrated chromosome 17p11.2 deletions, confirmed by FISH. We also made a meta-analysis of 165 cases reported between 1982 and 2010 to compare with the clinical data of our sample. We demonstrated differences between the frequencies of clinical signs among the cases reported and seven Brazilian cases of this study, such as dental anomalies, strabismus, ear infections, deep hoarse voice, hearing loss, and cardiac defects. Although the gold standard for diagnosis of SMS is FISH, we found that the GTG banding technique developed to evaluate chromosome 17 can be used for the SMS diagnosis in areas where the FISH technique is not available. PMID:22057962

Gamba, B F; Vieira, G H; Souza, D H; Monteiro, F F; Lorenzini, J J; Carvalho, D R; Morreti-Ferreira, D

2011-01-01

464

Autism spectrum features in Smith-Magenis syndrome.  

PubMed

Smith-Magenis syndrome (SMS; OMIM 182290) is a neurodevelopmental disorder characterized by a well-defined pattern of anomalies. The majority of cases are due to a common deletion in chromosome 17p11.2 that includes the RAI1 gene. In children with SMS, autistic-like behaviors and symptoms start to emerge around 18 months of age. This study included 26 individuals (15 females and 11 males), with a confirmed deletion (del 17p11.2). Parents/caregivers were asked to complete the Social Responsiveness Scale (SRS) and the Social Communication Questionnaire (SCQ) both current and lifetime versions. The results suggest that 90% of the sample had SRS scores consistent with autism spectrum disorders. Moreover, females showed more impairment in total T-scores (P?=?0.02), in the social cognition (P?=?0.01) and autistic mannerisms (P?=?0.002) subscales. The SCQ scores are consistent to show that a majority of individuals may meet criteria for autism spectrum disorders at some point in their lifetime. These results suggest that SMS needs to be considered in the differential diagnosis of autism spectrum disorders but also that therapeutic interventions for autism are likely to benefit individuals with SMS. The mechanisms by which the deletion of RAI1 and contiguous genes cause psychopathology remain unknown but they provide a solid starting point for further studies of gene-brain-behavior interactions in SMS and autism spectrum disorders. PMID:20981775

Laje, Gonzalo; Morse, Rebecca; Richter, William; Ball, Jonathan; Pao, Maryland; Smith, Ann C M

2010-11-15

465

Pharmacological treatment of disruptive behavior in Smith-Magenis syndrome.  

PubMed

Smith-Magenis syndrome (SMS) is a complex genetic syndrome caused by an interstitial deletion of chromosome 17p11.2. Children and adults with SMS appear to have unique neurobehavioral problems that include: sleep disturbance, self-injurious and maladaptive behaviors, stereotypies, and sensory integration disorders. We gathered retrospective psychotropic use information from parents or other caregivers of 62 individuals with SMS who were asked about use of psychotropic medication from a list of commonly used psychiatric medications. For those drugs identified, respondents were asked to rate the experience with the particular medication using a likert-type scale. Drugs were grouped into seven main categories: (1) stimulants; (2) antidepressants; (3) antipsychotics; (4) sleep aides; (5) mood stabilizers; (6) alpha 2 agonists; and (7) benzodiazepines. Relative frequencies, means and standard deviations pertaining to age and medication effect were derived for each medication category. Six of the seven medication categories examined showed no meaningful deviations from the "no change" score. The benzodiazepine group showed a mild detrimental effect. There were no gender differences in efficacy. Use of psychotropic medication started early in life (mean age 5 years), particularly with sleep aides. Although no medication category was identified as efficacious in SMS, all the categories reported herein may be considered as an option for brief symptomatic relief. PMID:20981776

Laje, Gonzalo; Bernert, Rebecca; Morse, Rebecca; Pao, Maryland; Smith, Ann C M

2010-11-15

466

Phenotype and natural history in Marshall-Smith syndrome.  

PubMed

Marshall-Smith syndrome (MSS) is a distinctive entity of unknown etiology with fewer than 50 patients described in the medical literature to date. Through an International collaboration and use of an online wiki to facilitate data collection and sharing, we further delineate the phenotype and natural history of this syndrome. We present 15 new patients, the oldest being 30 years, provide an update on four previously published cases, and compare all patients with other patients reported in literature. Main clinical features are moderate to severe developmental delay with absent or limited speech, unusual behavior, dysharmonic bone maturation, respiratory compromise secondary to upper airway obstruction, short stature, and kyphoscoliosis. Facial features are characteristic with high forehead, underdeveloped midface, proptosis, anteverted nares, and everted lips. Minor abnormalities of brain morphology such as hypoplasia of the corpus callosum are common. Mortality from respiratory complications is high, but airway support increasingly allows survival into adulthood. Array-CGH was performed on 12 of the cohort and no copy number variants of clear clinical relevance were identified. The present study is the first reported use of an online wiki to aid delineation of a genetic syndrome, and illustrates its value in collecting detailed data in rare conditions. PMID:20949508

Shaw, Adam C; van Balkom, Inge D C; Bauer, Mislen; Cole, Trevor R P; Delrue, Marie-Ange; Van Haeringen, Arie; Holmberg, Eva; Knight, Samantha J L; Mortier, Geert; Nampoothiri, Sheela; Pušelji?, Silvija; Zenker, Martin; Cormier-Daire, Valerie; Hennekam, Raoul C M

2010-11-01

467

Basic repository environmental assessment design basis: Deaf Smith County site  

SciTech Connect

This study examines the engineering factors and costs associated with the construction, operation, and decommissioning of a high-level nuclear waste repository in salt in the Palo Duro Basin in Deaf Smith County, Texas. The study assumes a repository capacity of 36,000 metric tons of heavy metal (MTHM) of unreprocessed spent fuel and 36,000 MTHM of commercial high-level reprocessing waste, along with 7,020 canisters of defense high-level reprocessing waste and associated quantities or remote- and contact-handled transuranic waste (TRU). With the exception of TRU, all the waste forms are placed in 300- to 1000-year-life carbon-steel waste packages in a collocated waste handling and packaging facility (WHPF), which is also described. The construction, operation, and decommissioning of the proposed repository is estimated to cost approximately $4.64 billion. Costs include those for the collocate WHPF, engineering, and contingency, but exclude waste form assembly and shipment to the site and waste package fabrication and shipment to the site. These costs reflect the relative average wage rates of the region, the relatively easy access to the site, and the relatively weak nature of the salt at this site. Construction would require an estimated 7 to 7.5 years. Engineering factors and costs are not strongly influenced by environmental considerations. 62 refs., 24 figs., 20 tabs.

Not Available

1988-03-01

468

Target Prediction for an Open Access Set of Compounds Active against Mycobacterium tuberculosis  

PubMed Central

Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), infects an estimated two billion people worldwide and is the leading cause of mortality due to infectious disease. The development of new anti-TB therapeutics is required, because of the emergence of multi-drug resistance strains as well as co-infection with other pathogens, especially HIV. Recently, the pharmaceutical company GlaxoSmithKline published the results of a high-throughput screen (HTS) of their two million compound library for anti-mycobacterial phenotypes. The screen revealed 776 compounds with significant activity against the M. tuberculosis H37Rv strain, including a subset of 177 prioritized compounds with high potency and low in vitro cytotoxicity. The next major challenge is the identification of the target proteins. Here, we use a computational approach that integrates historical bioassay data, chemical properties and structural comparisons of selected compounds to propose their potential targets in M. tuberculosis. We predicted 139 target - compound links, providing a necessary basis for further studies to characterize the mode of action of these compounds. The results from our analysis, including the predicted structural models, are available to the wider scientific community in the open source mode, to encourage further development of novel TB therapeutics. PMID:24098102

Martínez-Jiménez, Francisco; Papadatos, George; Yang, Lun; Wallace, Iain M.; Kumar, Vinod; Pieper, Ursula; Sali, Andrej; Brown, James R.; Overington, John P.; Marti-Renom, Marc A.

2013-01-01

469

Bioequivalence assay between orally disintegrating and conventional tablet formulations in healthy volunteers.  

PubMed

The purpose of this study was to evaluate bioequivalence of two commercial 8 mg tablet formulations of ondansetrona available in the Brazilian market. In this study, a simple, rapid, sensitive and selective liquid chromatography-tandem mass spectrometry method is described for the determination of ondansetron in human plasma samples. The method was validated over a concentration range of 2.5-60 ng/ml and used in a bioequivalence trial between orally disintegrating and conventional tablet ondansetron formulations, to assess its usefulness in this kind of study. Vonau flash (Biolab Sanus Farmacêutica, Brazil, as test formulations) and Zofran (GlaxoSmithKline, Brazil, as reference formulation) were evaluated following a single 8 mg dose to 23 healthy volunteers of both genders. The dose was administered after an overnight fast according to a two-way crossover design. Bioequivalence between the products was determinated by calculating 90% confidence interval (90% CI) for the ratio of C(max), AUC(0-t) and AUC(0-infinity) values for the test and reference products, using logarithmically transformed data. The 90% confidence interval for the ratio of C(max) (87.5-103.8%), AUC(0-t) (89.3-107.2%) and AUC(0-infinity) (89.7-106.0%) values for the test and reference products is within the 80-125% interval, proposed by FDA, EMEA and ANVISA. It was concluded that two ondansetron formulations are bioequivalent in their rate and extent of absorption. PMID:18848869

Armando, Yara Popst; Schramm, Simone Grigoleto; Silva, Marina de Freitas; Kano, Eunice Kazue; Koono, Eunice Emiko Mori; Porta, Valentina; Serra, Cristina Helena dos Reis

2009-01-21

470

New Compound Sets Identified from High Throughput Phenotypic Screening Against Three Kinetoplastid Parasites: An Open Resource  

PubMed Central

Using whole-cell phenotypic assays, the GlaxoSmithKline high-throughput screening (HTS) diversity set of 1.8 million compounds was screened against the three kinetoplastids most relevant to human disease, i.e. Leishmania donovani, Trypanosoma cruzi and Trypanosoma brucei. Secondary confirmatory and orthogonal intracellular anti-parasiticidal assays were conducted, and the potential for non-specific cytotoxicity determined. Hit compounds were chemically clustered and triaged for desirable physicochemical properties. The hypothetical biological target space covered by these diversity sets was investigated through bioinformatics methodologies. Consequently, three anti-kinetoplastid chemical boxes of ~200 compounds each were assembled. Functional analyses of these compounds suggest a wide array of potential modes of action against kinetoplastid kinases, proteases and cytochromes as well as potential host–pathogen targets. This is the first published parallel high throughput screening of a pharma compound collection against kinetoplastids. The compound sets are provided as an open resource for future lead discovery programs, and to address important research questions. PMID:25740547

Peña, Imanol; Pilar Manzano, M.; Cantizani, Juan; Kessler, Albane; Alonso-Padilla, Julio; Bardera, Ana I.; Alvarez, Emilio; Colmenarejo, Gonzalo; Cotillo, Ignacio; Roquero, Irene; de Dios-Anton, Francisco; Barroso, Vanessa; Rodriguez, Ana; Gray, David W.; Navarro, Miguel; Kumar, Vinod; Sherstnev, Alexander; Drewry, David H.; Brown, James R.; Fiandor, Jose M.; Julio Martin, J.

2015-01-01

471

Identification and characterization of hundreds of potent and selective inhibitors of Trypanosoma brucei growth from a kinase-targeted library screening campaign.  

PubMed

In the interest of identification of new kinase-targeting chemotypes for target and pathway analysis and drug discovery in Trypanosomal brucei, a high-throughput screen of 42,444 focused inhibitors from the GlaxoSmithKline screening collection was performed against parasite cell cultures and counter-screened against human hepatocarcinoma (HepG2) cells. In this way, we have identified 797 sub-micromolar inhibitors of T. brucei growth that are at least 100-fold selective over HepG2 cells. Importantly, 242 of these hit compounds acted rapidly in inhibiting cellular growth, 137 showed rapid cidality. A variety of in silico and in vitro physicochemical and drug metabolism properties were assessed, and human kinase selectivity data were obtained, and, based on these data, we prioritized three compounds for pharmacokinetic assessment and demonstrated parasitological cure of a murine bloodstream infection of T. brucei rhodesiense with one of these compounds (NEU-1053). This work represents a successful implementation of a unique industrial-academic collaboration model aimed at identification of high quality inhibitors that will provide the parasitology community with chemical matter that can be utilized to develop kinase-targeting tool compounds. Furthermore these results are expected to provide rich starting points for discovery of kinase-targeting tool compounds for T. brucei, and new HAT therapeutics discovery programs. PMID:25340575

Diaz, Rosario; Luengo-Arratta, Sandra A; Seixas, João D; Amata, Emanuele; Devine, William; Cordon-Obras, Carlos; Rojas-Barros, Domingo I; Jimenez, Elena; Ortega, Fatima; Crouch, Sabrinia; Colmenarejo, Gonzalo; Fiandor, Jose Maria; Martin, Jose Julio; Berlanga, Manuela; Gonzalez, Silvia; Manzano, Pilar; Navarro, Miguel; Pollastri, Michael P

2014-10-01

472

Identification, biological characterization and pharmacophoric analysis of a new potent and selective NK1 receptor antagonist clinical candidate.  

PubMed

The last two decades have provided a large weight of preclinical data implicating the neurokinin-1 receptor (NK1) and its cognate ligand substance P (SP) in a broad range of both central and peripheral disease conditions. However, to date, only the NK1 receptor antagonist aprepitant has been approved as a therapeutic and this is to prevent chemotherapy-induced nausea & vomiting (CINV). The belief remained that the full therapeutic potential of NK1 receptor antagonists had yet to be realized; therefore clinical evidence that NK1 receptor antagonists may be effective in major depression disorder, resulted in a significant further investment in discovering novel CNS penetrant druggable NK1 receptor antagonists to address this condition. At GlaxoSmithKline after the discovery of casopitant, that went on to demonstrate efficacy as a novel antidepressant in the clinic, additional novel analogues of this NK1 receptor antagonist were designed to further enhance its drug developability characteristics. Herein, we therefore describe the discovery process and the vivo pharmacological and pharmacokinetic profile of the new NK1 receptor antagonist 3a (also called orvepitant), selected as clinical candidate and further progressed into clinical studies for major depressive disorder. Moreover, molecular modeling studies enabled us to improve the pharmacophore model of the NK1 receptor antagonists with the identification of a region able to accommodate a variety of heterocycle moieties. PMID:24075145

Di Fabio, Romano; Alvaro, Giuseppe; Braggio, Simone; Carletti, Renzo; Gerrard, Philip A; Griffante, Cristiana; Marchioro, Carla; Pozzan, Alfonso; Melotto, Sergio; Poffe, Alessandro; Piccoli, Laura; Ratti, Emiliangelo; Tranquillini, Elvira; Trower, Michael; Spada, Simone; Corsi, Mauro

2013-11-01

473

Preclinical efficacy of MEK inhibition in Nras-mutant AML  

PubMed Central

Oncogenic NRAS mutations are highly prevalent in acute myeloid leukemia (AML). Genetic analysis supports the hypothesis that NRAS mutations cooperate with antecedent molecular lesions in leukemogenesis, but have limited independent prognostic significance. Using short hairpin RNA–mediated knockdown in human cell lines and primary mouse leukemias, we show that AML cells with NRAS/Nras mutations are dependent on continued oncogene expression in vitro and in vivo. Using the Mx1-Cre transgene to inactivate a conditional mutant Nras allele, we analyzed hematopoiesis and hematopoietic stem and progenitor cells (HSPCs) under normal and stressed conditions and found that HSPCs lacking Nras expression are functionally equivalent to normal HSPCs in the adult mouse. Treating recipient mice transplanted with primary NrasG12D AMLs with 2 potent allosteric mitogen-activated protein kinase kinase (MEK) inhibitors (PD0325901 or trametinib/GlaxoSmithKline 1120212) significantly prolonged survival and reduced proliferation but did not induce apoptosis, promote differentiation, or drive clonal evolution. The phosphatidylinositol 3-kinase inhibitor GDC-0941 was ineffective as a single agent and did not augment the activity of PD0325901. All mice ultimately succumbed to progressive leukemia. Together, these data validate oncogenic N-Ras signaling as a therapeutic target in AML and support testing combination regimens that include MEK inhibitors. PMID:25361812

Burgess, Michael R.; Hwang, Eugene; Firestone, Ari J.; Huang, Tannie; Xu, Jin; Zuber, Johannes; Bohin, Natacha; Wen, Tiffany; Kogan, Scott C.; Haigis, Kevin M.; Sampath, Deepak; Lowe, Scott; Shannon, Kevin

2014-01-01

474

Efficient Synthesis and Anti-Tubercular Activity of a Series of Spirocycles: An Exercise in Open Science  

PubMed Central

Tuberculosis afflicts an estimated 2 billion people worldwide and causes 1.3 million deaths annually. Chemotherapeutic solutions rely on drugs developed many years ago, with only one new therapeutic having been approved in the last 40 years. Given the rise of drug-resistant strains, there is an urgent need for the development of a more robust drug development pipeline. GlaxoSmithKline recently placed the structures and activities of 177 novel anti-tubercular leads in the public domain, as well as the results of ongoing optimisation of some of the series. Since many of the compounds arose from screening campaigns, their provenance was unclear and synthetic routes were in many cases not reported. Here we present the efficient synthesis of several novel analogues of one family of the GSK compounds—termed “Spiros”—using an oxa-Pictet–Spengler reaction. The new compounds are attractive from a medicinal chemistry standpoint and some were potent against the virulent strain, suggesting this class is worthy of further study. The research was carried out using open source methodology, providing the community with full access to all raw experimental data in real time. PMID:25493550

Badiola, Katrina A.; Quan, Diana H.; Triccas, James A.; Todd, Matthew H.

2014-01-01

475

Keystone Symposium on Antibodies as Drugs  

PubMed Central

The symposium on Antibodies as Drugs, organized by Keystone Symposia and chaired by J. Marks, (University of California Los Angeles, USA), E.S. Ward (University of Texas Southwestern Medical Center, USA) and L. Weiner (Georgetown University Medical Center, USA), was held in Whistler, British Columbia. This Canadian Rockies village, which will host the 2010 Olympic Games, served as an enchanting backdrop to the meeting. The more than 350 speakers and attendees included scientists from major pharmaceutical firms, e.g., Abbott, MedImmune/Astra Zeneca, Bristol-Myers Squibb, Merck & Co., Pfizer, Sanofi-Aventis, Schering, GlaxoSmithKline, Eli Lilly, Hoffmann LaRoche, Novartis, Wyeth, and biotechnology companies, e.g., Ablynx, Medarex, Morphosys, GenMab, Amgen, Genentech, ImmunoGen, Agensys, Domantis, Biogen Idec, Centocor, LFB, Micromet, PDL Biopharma, Borean Pharma, Dyax Corp., Symphogen and Syntonix. Academic research groups at Imperial College London, University of Oxford, ETH Zürich, Scripps, Institute Cochin, Karolinska Institute, Utrecht University, Harvard Medical School, Massachusetts Institute of Technology, Baylor College, Paul Ehrlich Institute, University of California San Francisco, University of California San Diego, University of Nantes, University of Tours and Ludwig Institute were also represented, as were regulatory authorities, including the US Food and Drug Administration, National Institutes of Health and the Public Health Agency of Canada). The meeting was very interactive and included thoughtful exchanges during the different sessions and networking events. PMID:20068403

Larbouret, Christel; Robert, Bruno

2009-01-01

476

Identification and Characterization of Hundreds of Potent and Selective Inhibitors of Trypanosoma brucei Growth from a Kinase-Targeted Library Screening Campaign  

PubMed Central

In the interest of identification of new kinase-targeting chemotypes for target and pathway analysis and drug discovery in Trypanosomal brucei, a high-throughput screen of 42,444 focused inhibitors from the GlaxoSmithKline screening collection was performed against parasite cell cultures and counter-screened against human hepatocarcinoma (HepG2) cells. In this way, we have identified 797 sub-micromolar inhibitors of T. brucei growth that are at least 100-fold selective over HepG2 cells. Importantly, 242 of these hit compounds acted rapidly in inhibiting cellular growth, 137 showed rapid cidality. A variety of in silico and in vitro physicochemical and drug metabolism properties were assessed, and human kinase selectivity data were obtained, and, based on these data, we prioritized three compounds for pharmacokinetic assessment and demonstrated parasitological cure of a murine bloodstream infection of T. brucei rhodesiense with one of these compounds (NEU-1053). This work represents a successful implementation of a unique industrial-academic collaboration model aimed at identification of high quality inhibitors that will provide the parasitology community with chemical matter that can be utilized to develop kinase-targeting tool compounds. Furthermore these results are expected to provide rich starting points for discovery of kinase-targeting tool compounds for T. brucei, and new HAT therapeutics discovery programs. PMID:25340575

Diaz, Rosario; Luengo-Arratta, Sandra A.; Seixas, João D.; Amata, Emanuele; Devine, William; Cordon-Obras, Carlos; Rojas-Barros, Domingo I.; Jimenez, Elena; Ortega, Fatima; Crouch, Sabrinia; Colmenarejo, Gonzalo; Fiandor, Jose Maria; Martin, Jose Julio; Berlanga, Manuela; Gonzalez, Silvia; Manzano, Pilar; Navarro, Miguel; Pollastri, Michael P.

2014-01-01

477

Once-weekly albiglutide in the management of type 2 diabetes: patient considerations  

PubMed Central

This review describes the pharmacologic, pharmacokinetic, and pharmacodynamic properties of albiglutide, as well as its clinical efficacy and safety. Albiglutide is a novel, once-weekly, injectable glucagon-like peptide-1 receptor agonist for the treatment of type 2 diabetes. The European Commission recently granted marketing authorization for the drug in the European Union and on April 15, 2014, the US Food and Drug Administration approved albiglutide (Tanzeum™ [GlaxoSmithKline LLC, Wilmington, DE, USA]) to improve glycemic control in adults with type 2 diabetes. Albiglutide has been studied in Phase I, II, and III clinical trials. In the Phase III clinical trials, known as the Harmony series, weekly dosing of albiglutide demonstrated reductions in fasting plasma glucose, postprandial plasma glucose, and glycated hemoglobin, and was associated with weight loss. In all phases of the clinical trials, albiglutide administered once weekly showed a safety and tolerability profile similar to that of placebo, with mild gastrointestinal-related complaints and injection site erythema being the most commonly encountered adverse effects. Compared with pioglitazone and liraglutide, albiglutide has been shown to be clinically less effective. However, it offers the benefit of weight loss that pioglitazone does not, with fewer gastrointestinal side effects than liraglutide. As guidelines continue to advocate for patient-centered treatment strategies, once-weekly albiglutide will be an important addition to the growing armamentarium of treatment options for adults with type 2 diabetes needing target glycemic control. PMID:24926194

Woodward, Heather N; Anderson, Sarah L

2014-01-01

478

Young people's comparative recognition and recall of an Australian Government Sexual Health Campaign.  

PubMed

In 2009, the Australian Government's National Sexually Transmitted Infection Prevention Program launched a multi-million dollar sexual health campaign targeting young people. We assessed campaign recognition among a community sample of young people. Individuals aged 16-29 years self-completed a questionnaire at a music festival. Participants were asked whether they recognised the campaign image and attempted to match the correct campaign message. Recognition of two concurrent campaigns, GlaxoSmithKline's The Facts genital herpes campaign (targeting young women) and the Drama Downunder campaign (targeting gay men) were assessed simultaneously. Among 471 participants, just 29% recognised the National Sexually Transmitted Infection Prevention Program campaign. This compared to 52% recognising The Facts and 27% recognising Drama Downunder. Of 134 who recognised the National Sexually Transmitted Infection Prevention Program campaign, 27% correctly recalled the campaign messages compared to 61% of those recognising the Facts campaign, and 25% of those recognising the Drama Downunder campaign. There was no difference in National Sexually Transmitted Infection Prevention Program campaign recognition by gender or age. Campaign recognition and message recall of the National Sexually Transmitted Infection Prevention Program campaign was comparatively low. Future mass media sexual health campaigns targeting young people can aim for higher recognition and recall rates than that achieved by the National Sexually Transmitted Infection Prevention Program campaign. Alternative distribution channels and message styles should be considered to increase these rates. PMID:25006041

Lim, Megan Sc; Gold, Judy; Bowring, Anna L; Pedrana, Alisa E; Hellard, Margaret E

2015-05-01

479

OOMMPPAA: A Tool To Aid Directed Synthesis by the Combined Analysis of Activity and Structural Data  

PubMed Central

There is an ever increasing resource in terms of both structural information and activity data for many protein targets. In this paper we describe OOMMPPAA, a novel computational tool designed to inform compound design by combining such data. OOMMPPAA uses 3D matched molecular pairs to generate 3D ligand conformations. It then identifies pharmacophoric transformations between pairs of compounds and associates them with their relevant activity changes. OOMMPPAA presents this data in an interactive application providing the user with a visual summary of important interaction regions in the context of the binding site. We present validation of the tool using openly available data for CDK2 and a GlaxoSmithKline data set for a SAM-dependent methyl-transferase. We demonstrate OOMMPPAA’s application in optimizing both potency and cell permeability and use OOMMPPAA to highlight nuanced and cross-series SAR. OOMMPPAA is freely available to download at http://oommppaa.sgc.ox.ac.uk/OOMMPPAA/. PMID:25244105

2014-01-01

480

Performance of rotavirus vaccines in developed and developing countries  

PubMed Central

The World Health Organization estimates that rotavirus diarrhea results in approximately half a million deaths and approximately 2.4 million hospitalizations in developing countries each year. Two live oral rotavirus vaccines, RotaTeq® (RV 5; Merck) and Rotarix® (RV 1; GlaxoSmithKline) with good efficacy against severe rotavirus disease and a reassuring safety profile could substantially impact the burden of rotavirus disease. In April 2009, WHO provided a recommendation for global introduction of these vaccines in national immunization programs of developing countries worldwide. In this article, we review published data on previous candidate rotavirus vaccines and vaccines in current use, with emphasis on their performance in developed versus developing countries. In developed countries, both first and second generation rotavirus vaccines have demonstrated high efficacy against severe rotavirus disease (pooled efficacy = 73% and 85%, respectively). In developing countries, small early trials for the first generation vaccines failed to provide protection against rotavirus disease (pooled efficacy = 20%), however, trials of the second generation vaccines yielded substantial improvements in efficacy in developing countries (pooled efficacy of 51%), leading to a global recommendation for rotavirus vaccine introduction by WHO. Future efforts for these vaccines should focus on optimizing the efficacy and delivery of these vaccines in challenging target populations of Asia and Africa with the greatest burden of severe rotavirus disease. PMID:20622508

Jiang, Victoria; Jiang, Baoming; Tate, Jacqueline; Parashar, Umesh D

2010-01-01

481

Is PDE4 too difficult a drug target?  

PubMed

The search for selective inhibitors of PDE4 as novel anti-inflammatory drugs has continued for more than 30 years. Although several compounds have demonstrated therapeutic effects in diseases such as asthma, COPD, atopic dermatitis and psoriasis, none have reached the market. A persistent challenge in the development of PDE4 inhibitors has been drug-induced gastrointestinal adverse effects, such as nausea. However, extensive clinical trials with well-tolerated doses of roflumilast (Daxas; Nycomed/Mitsubishi Tanabe Pharma Corp/Forest Laboratories Inc) in COPD, a disease that is generally unresponsive to existing therapies, have demonstrated significant therapeutic improvements. In addition, GlaxoSmithKline plc is developing 256066, an inhaled formulation of a PDE4 inhibitor that has demonstrated efficacy in trials in asthma, and apremilast from Celgene Corp has been reported to be effective for the treatment of psoriasis. Despite the challenges and complications that have been encountered during the development of PDE4 inhibitors, these drugs may provide a genuinely novel class of anti-inflammatory agents, and there are several compounds in development that could fulfill that promise. PMID:20419594

Higgs, Gerry

2010-05-01

482

The Acute Extracellular Flux (XF) Assay to Assess Compound Effects on Mitochondrial Function.  

PubMed

Numerous investigations have linked mitochondrial dysfunction to adverse health outcomes and drug-induced toxicity. The pharmaceutical industry is challenged with identifying mitochondrial liabilities earlier in drug development and thereby reducing late-stage attrition. Consequently, there is a demand for reliable, higher-throughput screening methods for assessing the impact of drug candidates on mitochondrial function. The extracellular flux (XF) assay described here is a plate-based method in which galactose-conditioned HepG2 cells were acutely exposed to test compounds, then real-time changes in the oxygen consumption rate and extracellular acidification rate were simultaneously measured using a Seahorse Bioscience XF-96 analyzer. The acute XF assay was validated using marketed drugs known to modulate mitochondrial function, and data analysis was automated using a spline curve fitting model developed at GlaxoSmithKline. We demonstrate that the acute XF assay is a robust, sensitive screening platform for evaluating drug-induced effects on mitochondrial activity in whole cells. PMID:25381255

Wang, Ruolan; Novick, Steven J; Mangum, James B; Queen, Kennedy; Ferrick, David A; Rogers, George W; Stimmel, Julie B

2015-03-01

483

Combined hexavalent diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus-Haemophilus influenzae type B vaccine; Infanrix™ hexa: twelve years of experience in Italy.  

PubMed

Infant vaccination using 2-dose priming at 3 and 5 mo of age with a booster at 11-12 mo of age was pioneered in Italy. The 3-5-11 schedule is now used in a growing number of European countries. Infanrix™ hexa (DTPa-HBV-IPV/Hib, GlaxoSmithKline Vaccines) was first licensed for use in 2000 and has been the only pediatric hexavalent vaccine available since 2005. We reviewed available clinical trial data describing the immunogenicity of DTPa-HBV-IPV/Hib when administered at 3, 5, and 11 mo of age, and conducted an analysis of safety using global and Italian post-marketing surveillance data. In Italy, DTPa-HBV-IPV/Hib has a demonstrated safety record extending over a decade of use, it has been associated with record levels of vaccine coverage, and with sustained disease control in vaccinated cohorts. Hexavalent vaccines will continue to contribute to high vaccine coverage in Italy and across Europe. PMID:24004825

Baldo, Vincenzo; Bonanni, Paolo; Castro, Marcela; Gabutti, Giovanni; Franco, Elisabetta; Marchetti, Federico; Prato, Rosa; Vitale, Francesco

2014-01-01

484

New antiepileptic medication linked to blue discoloration of the skin and eyes  

PubMed Central

Ezogabine is an antiepileptic medication approved in June 2011 by the US Food and Drug Administration (FDA) as an adjunctive treatment for partial seizures. Minimal drug interactions and a novel mechanism of action made ezogabine an appealing new treatment option. However, adverse effects reported during clinical trials and following drug approval have been alarming. A Risk Evaluation Mitigation Strategy (REMS) program has been established for urinary retention. A safety alert was published in April 2013 warning ezogabine may cause retinal pigment abnormalities and/or blue-gray discoloration, most notably on or near the lips, nail beds, sclera and conjunctiva with long-term use. In October 2013, the FDA announced a formal label change to ezogabine to include a black boxed warning emphasizing the previously reported warnings of eye and skin discoloration and permanent vision changes. Given the unknown nature of the pathophysiology, consequences and potential for reversibility of these effects, GlaxoSmithKline and the FDA have published recommendations for patients currently receiving ezogabine. Further data from published case reports and long-term safety trials in the future may lend additional insight into these concerning effects. PMID:25642319

Antell, Alexandra; Kaufman, Kimberly

2015-01-01

485

Comparative study of the quality and efficacy of originator and generic albendazole for mass treatment of soil-transmitted nematode infections in Nepal.  

PubMed

The quality and efficacy of two locally manufactured generic albendazole (ABZ) products (Curex and Royal Drug) used for deworming children in Nepal since 1999 were tested against the originator product (GlaxoSmithKline (GSK)). The study included disintegration and dissolution testing according to the Indian Pharmacopoeia (IP) and the United States Pharmacopeia (USP), respectively, as well as a randomised controlled clinical trial comparing cure rates (CR) and egg reduction rates (ERR) for Ascaris lumbricoides, Trichuris trichiura and hookworm infections. Stool samples from 1277 children were examined before and 21 days after treatment. For A. lumbricoides, GSK (97.0%) and Royal Drug (95.0%) ABZ achieved significantly higher CRs than Curex ABZ (82.6%); however, all products achieved ERRs >90%. For T. trichiura, Curex ABZ showed significantly lower ERRs (63.2%). For hookworms, GSK ABZ performed significantly better (CR 74.3%, ERR 87.1%) than Royal Drug ABZ (CR 53.3%, ERR 80.8%) and Curex ABZ (CR 50.7%, ERR 73.1%). Only the GSK product passed both disintegration and dissolution tests according to the IP and USP. Both generic products failed the dissolution tests. Curex ABZ showed poor disintegration. Despite its lower efficacy, the cheaper Curex product achieved good results in controlling morbidity due to soil-transmitted helminth infections. This study shows that the cost effectiveness of drugs used in mass deworming campaigns should not be inferred on the basis of a single quality testing parameter. PMID:17129592

Albonico, Marco; Mathema, Pragya; Montresor, Antonio; Khakurel, Balkrishna; Reggi, Valerio; Pandey, Sharada; Savioli, Lorenzo

2007-05-01

486

Model-based approach and signal detection theory to evaluate the performance of recruitment centers in clinical trials with antidepressant drugs.  

PubMed

The objective of this study was to characterize the performance of each recruitment center in multicenter clinical trials and to provide criteria to discriminate between informative and noninformative centers using the signal detection approach. Data were derived from the GlaxoSmithKline Clinical Trial database on paroxetine and bupropion, totaling 4,016 subjects with major depressive disorders (MDDs) across nine trials. The probability of observing clinically relevant difference of active treatment from placebo was estimated in each center as a function of the placebo Hamilton Depression Rating Scale (HAMD-17) scores at baseline and at week 8. The center's performance was defined using the posterior probability (PP) of detecting a signal of a treatment effect. Only 60% of the centers were classified as informative. In these centers, the signal of treatment effect increased by approximately 80%. The signal detection approach appears to be a useful methodology to rank the performance of recruitment centers and to classify each center as informative or not in respect of detection of clinically relevant signals of efficacy. A further analysis indicated that a minimal sample of four subjects is required in order to predict the typical placebo response in each center. PMID:18449185

Merlo-Pich, E; Gomeni, R

2008-09-01

487

Prevalence of sleep problems in Smith-Lemli-Opitz syndrome.  

PubMed

Smith-Lemli-Opitz syndrome (SLOS) is an autosomal recessive genetic disorder, characterized by multiple congenital anomalies, and intellectual disability. It is caused by a genetically inherited deficiency of the enzyme 7-dehydrocholesterol-delta-7-reductase, which results in increased serum levels of 7-dehydrocholesterol (7-DHC), and decreased levels of cholesterol. This study assesses the prevalence of sleep problems in patients with SLOS. The study group comprised 18 subjects with SLOS, ages 2-31 years (median 10.7 ± 8.5 years). Parents completed several questionnaires (Intake Demographic Form; Pediatric Sleep Questionnaire; Pediatric Daytime Sleepiness Scale). The SLOS subjects had symptoms of sleep-disordered breathing (50% snoring; 66.7% mouth breathing), problems with sleep onset [difficulty falling asleep (61.1%) sleep onset time >30 min (62%)], sleep maintenance [wake up screaming (61.1%), waking up more than twice (44.4%), having trouble falling back to sleep (66.7%), waking up early in the morning (61.1%), and restless sleep (50%)]. The subjects with SLOS needed parents in the room to fall asleep (50%), watch TV or listen to music to fall asleep (44.4%), and described bed sharing (33.3%), indicating sleep-anxiety and sleep-associations. Symptoms of excessive-daytime-sleepiness were frequently reported [un-refreshed in the morning (38.9%), daytime sleepiness (44.4%), and daytime naps (55.6%)]. Parents frequently observed difficulty of organizing tasks (66.7%), and easy distractibility (88.9%). Sleep problems such as sleep-disordered breathing, sleep-related anxiety and sleep associations, disturbed sleep patterns at night, and excessive daytime sleepiness are frequent in children with SLOS. PMID:21626671

Zarowski, Marcin; Vendrame, Martina; Irons, Mira; Kothare, Sanjeev V

2011-07-01

488

Draft environmental assessment: Deaf Smith County site, Texas. Nuclear Waste Policy Act (Section 112). [Contains Glossary  

SciTech Connect

In February 1983, the US Department of Energy identified a location in Deaf Smith County, Texas, as one of nine potentially acceptable sites for a mined geologic repository for spent nuclear fuel and high-level radioactive waste. The potentially acceptable site was subsequently narrowed to an area of 9 square miles. To determine their suitability, the Deaf Smith site and the eight other potentially acceptable sites have been evaluated in accordance with the DOE's General Guidelines for the Recommendation of Sites for Nuclear Waste Repositories. These evaluations are reported in this draft environmental assessment, which is being issued for public review and comment. The DOE findings and determinations that are based on these evaluations are preliminary and subject to public review and comment. A final EA will be prepared after considering the comments received. On the basis of the evaluations reported in this draft EA, the DOE has found that the Deaf Smith site is not disqualified under the guidelines. The site is in the Permian Basin, which is one of five distinct geohydrologic settings considered for the first repository. This setting contains one other potentially acceptable site - the Swisher site. Although the Swisher site appears to be suitable for site characterization, DOE has concluded that the Deaf Smith site is the preferred site. The DOE finds that the site is suitable for site characterization because the evidence does not support a conclusion that the site will not be able to meet each of the qualifying conditions specified in the guidelines. On the basis of these findings, the DOE is proposing to nominate the Deaf Smith site as one of five sites suitable for characterization. Having compared the Deaf Smith site with the other four sites proposed for nomination, the DOE has determined that the Deaf Smith site is one of the three preferred sites for recommendation to the President as candidates for characterization.

Not Available

1984-12-01

489

Muscle damage during MIS total hip arthroplasty: Smith-Petersen versus posterior approach.  

PubMed

Decreased muscle damage is a reported benefit of minimally invasive surgical (MIS) approaches in total hip arthroplasty (THA). We compared the extent and location of muscle damage during THA using the MIS anterior Smith-Petersen and MIS posterior surgical approaches. THA was performed in six human cadavers (12 hips). One hip was assigned to the Smith-Petersen approach and the contralateral hip to the posterior approach. Muscle damage was graded with a technique of visual inspection to calculate a proportion of surface area damage. Less damage occurred in the gluteus minimus muscles and minimus tendon with the Smith-Petersen approach. A mean of 8% of the minimus muscle was damaged via the Smith-Petersen approach, compared to 18% via the posterior approach. The tensor fascia latae muscle was damaged (mean of 31%), as well as direct head of the rectus femoris (mean 12%) during the Smith-Petersen approach. The piriformis or conjoined tendon was transected in 50% of the anterior approaches to mobilize the femur. The posterior approach involved intentional detachment of the piriformis and conjoined tendon and measurable damage to the abductor muscles and gluteus minimus tendon in each specimen. Clinical outcome studies and gait analysis are necessary to ascertain the functional implications of these findings. PMID:17006366

Meneghini, R Michael; Pagnano, Mark W; Trousdale, Robert T; Hozack, William J

2006-12-01

490

Searching for Dark Matter Annihilation in the Smith High-Velocity Cloud  

E-print Network

Recent observations suggest that some high-velocity clouds may be confined by massive dark matter halos. In particular, the proximity and proposed dark matter content of the Smith Cloud make it a tempting target for the indirect detection of dark matter annihilation. We argue that the Smith Cloud may be a better target than some Milky Way dwarf spheroidal satellite galaxies and use gamma-ray observations from the Fermi Large Area Telescope to search for a dark matter annihilation signal. No significant gamma-ray excess is found coincident with the Smith Cloud, and we set strong limits on the dark matter annihilation cross section assuming a spatially-extended dark matter profile consistent with dynamical modeling of the Smith Cloud. Notably, these limits exclude the canonical thermal relic cross section ($\\sim 3\\times10^{-26}{\\rm cm}^{3}{\\rm s}^{-1}$) for dark matter masses $\\lesssim 30$ GeV annihilating via the $b \\bar b$ or $\\tau^{+}\\tau^{-}$ channels for certain assumptions of the dark matter density profile; however, uncertainties in the dark matter content of the Smith Cloud may significantly weaken these constraints.

Alex Drlica-Wagner; German A. Gomez-Vargas; John W. Hewitt; Tim Linden; Luigi Tibaldo

2014-06-30

491

Adrenal function in Smith-Lemli-Opitz Syndrome  

PubMed Central

Smith-Lemli-Opitz syndrome (SLOS) is a multiple malformation syndrome due to mutations of the 7-dehydrocholesterol reductase gene (DHCR7), which leads to a deficiency of cholesterol synthesis and an accumulation of 7-dehydrocholesterol and related metabolites. The SLOS clinical spectrum ranges from multiple major malformations to a mild phenotype with dysmorphic features, intellectual disability and a specific behavioral presentation. Several cases of SLOS with adrenal insufficiency have been described. We performed ovine corticotropin (oCRH) testing in 35 SLOS patients and 16 age- and gender-matched controls. We reviewed prior ACTH stimulation tests of our SLOS patients (19 of 35 available) and reviewed ACTH stimulation tests from additional 10 other SLOS patients. Results from oCRH testing showed that patients with SLOS had significantly higher ACTH baseline values than healthy controls (24.8 ± 15.3 pg/mL vs. 17.8 ± 7.5 pg/mL, p=0.034). However, no statistically significant differences were noted for peak ACTH values (74.4 ± 35.0 pg/mL vs. 64.0 ± 24.9 pg/mL, p=0.303) and for baseline (14.2 ± 7.8 mcg/dL vs. 14.2 ± 6.3 mcg/dL, p=0.992) and peak cortisol values (28.2 ± 7.9 mcg/dL vs. 24.8 ± 8.1 mcg/dL, p=0.156). The area-under-the-curve (AUC) was not significantly different in SLOS patients compared to controls for both ACTH (250.1 ± 118.7 pg/mL vs. 195.3 ± 96.6 pg/mL, p=0.121) as well as cortisol secretion (83.1 ± 26.1 mcg/dL vs. 77.8 ± 25.9 mcg/dL, p=0.499). ACTH stimulation test was normal in 28 of 29 tests. The individual with the abnormal ACTH stimulation test had a normal oCRH test during the same evaluation. The slightly increased baseline ACTH level seen during oCRH testing may be due to compensated mild adrenocortical insufficiency. However, we were able to show that our cohort affected with SLOS had an adequate stress response and that in mild to moderate cases of SLOS stress steroid coverage should not be required. PMID:21990131

Bianconi, Simona E; Conley, Sandra K; Keil, Meg F; Sinaii, Ninet; Rother, Kristina I; Porter, Forbes D; Stratakis, Constantine A

2012-01-01

492

A modern approach to pilot/vehicle analysis and the Neal-Smith criteria  

NASA Technical Reports Server (NTRS)

The present investigation is concerned with the development of a better pilot modelling technique via optimal control theory, taking into account concepts concerning 'pilot rating' considered by Neal and Smith (1970). The investigation conducted by Neal and Smith had the objective to provide data on the effects of Flight Control System dynamics and to develop a design criterion capable of pinpointing pilot problem areas encountered in performing a given task. Neal and Smith devised a 'pilot-in-the-loop' analysis capable of showing problem areas in pitch attitude tracking. Unfortunately the employed method has some drawbacks. The current investigation attempts, therefore, to provide an alternate approach which makes use of an optimal-control pilot model. An optimal control model (OCM) had been discussed by Kleinman et al. (1970). It is shown that the alternate approach, based on the OCM, offers some distinct advantages.

Bacon, B. J.; Schmidt, D. K.

1982-01-01

493

Geology, paleoclimatology and the evolution of the kidney: some explorations into the legacy of Homer Smith.  

PubMed

The aim of this review is to perform an overview of the relation between kidney development in different species and new developments in plate tectonics and paleoclimatology, which likely had a remarkable effect on evolution. The review follows the ideas of Homer Smith, but adds new data on the subjects which were unknown in Homer Smith's time. The structure and function of the kidney are a result of hundreds of millions of years of evolution, in which adaptations had to be made in response to environmental demands while maintaining the kidney's integrated function. The ideas of Homer Smith have greatly contributed to our understanding of this process, and continue to be of relevance both for researchers as well as physicians working in the field of kidney disease. PMID:22572704

Kooman, Jeroen P

2012-01-01

494

Smith-Doxey Classification, Fiber Testing and Problems of the Cotton Trade.  

E-print Network

or we mailed a questionnaire in June 1955 and were asked the following questions: 1. To what extent are Texas cotton merchants buying cotton on the basis of Smith-Dox classification and what are their chief criticisms of this classing service? 2... shippers, f.0.b. merchants, spot brokers and mill buyers. Of the 65 firms, 53 indicated they purchase some cotton on Smith-Doxey classification and about 38 percent of their total purchases were made on the basis of "green cards" in 1951. Thirty...

Hunt, Robert L.

1956-01-01

495

Improve growth rate of Smith-Purcell free-electron laser by Bragg reflector  

NASA Astrophysics Data System (ADS)

Grating with Bragg reflectors for the Smith-Purcell free-electron laser is proposed to improve the reflection coefficient, resulting in enhancing the interaction of the surface wave with the electron beam and, consequently, relax the requirements to the electron beam. With the help of particle-in-cell simulations, it has been shown that the usage of Bragg reflectors may improve the growth rate, shorten the time for the device to reach saturation, and lower the start current for the operation of a Smith-Purcell free-electron laser.

Li, D.; Yang, Z.; Tsunawaki, Y.; Asakawa, M. R.; Hangyo, M.; Miyamoto, S.; Imasaki, K.

2011-05-01

496

Smith-Purcell radiation from a grating of negative-index material  

NASA Astrophysics Data System (ADS)

Smith-Purcell radiation from an electric line charge that moves, at constant speed, parallel to a grating made of metamaterial with negative index is analyzed. Through theoretical analysis and computations, we show that the Smith-Purcell radiation is stronger from a grating of negative-index material, than that from a positive-index material and perfect conductor. Also, we found that the radiation strongly depends on the values of permeability and permittivity. Calculations on grating with saw-like profile and rectangular profile are also carried out and demonstrated.

Li, D.; Hangyo, M.; Yang, Z.; Asakawa, M. R.; Miyamoto, S.; Tsunawaki, Y.; Takano, K.; Imasaki, K.

2011-05-01

497

Design of a grating for studying Smith-Purcell radiation and electron acceleration  

SciTech Connect

We describe work on the design of a diffraction grating which we intend to use for studying the production of Smith-Purcell radiation and the acceleration of electrons. We have developed computer codes based on the solution of the appropriate Maxwell's equations. A specific grating profile is given which is feasible to construct and which supports enhanced surface accelerating modes. We examine the possibility of using the Smith-Purcell effect to make a beam position monitor. 13 refs., 10 figs., 2 tabs.

Fernow, R.C.

1989-01-01

498

75 FR 11919 - Smith and Nephew, Inc., Wound Management-Largo Division, Including On-Site Leased Workers From...  

Federal Register 2010, 2011, 2012, 2013, 2014

...TA-W-70,151] Smith and Nephew, Inc., Wound Management-Largo Division, Including...to workers of Smith and Nephew, Inc., Wound Management-Largo Division, Largo, Florida...activities related to the production of advanced wound care products such as adhesive...

2010-03-12

499

The Viability of a Single-Sex College in Modern Society: Amherst, Smith, and the Question of Coeducation.  

ERIC Educational Resources Information Center

Looks at coeducation decisions made by Smith and Amherst Colleges in 1970s, Smith reaffirming its commitment to separate education and Amherst changing from all-male to coeducational college. Describes contrasting bases for the decisions made by the two colleges. (NB)

McPhie, Laura E.

1991-01-01

500

Business Ethics and the Origins of Contemporary Capitalism: Economics and Ethics in the Work of Adam Smith and Herbert Spencer  

Microsoft Academic Search

Both Adam Smith and Herbert spencer, albeit in quite different ways, have been enormously influential in what we today take to be philosophies of modern capitalism. Surprisingly it is Spencer, not Smith, who is the individualist, perhaps an egoist, and supports a \\

Patricia H. Werhane

2000-01-01