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1

Cilomilast GlaxoSmithKline.  

PubMed

GlaxoSmithKline is developing cilomilast, a phosphodiesterase 4 inhibitor, for the potential treatment of chronic obstructive pulmonary disease. The compound has been assessed in phase III clinical trials. PMID:15912970

Brown, William M

2005-05-01

2

Boostrix (GlaxoSmithKline).  

PubMed

GlaxoSmithKline plc has developed and launched Boostrix, a subunit vaccine for use in adolescents and adults as a booster immunization against diphtheria, tetanus and pertussis (DTPa) infections. PMID:16044375

Jones, Taff

2005-08-01

3

Talnetant GlaxoSmithKline.  

PubMed

Talnetant (SB-223412) is a selective, orally active NK3 antagonist based on 4-quinolinecarboxamide, and is under development by GlaxoSmithKline (formerly SmithKline Beecham) for the potential treatment of several disorders, including urinary incontinence, irritable bowel syndrome and schizophrenia. By November 2004, the compound had completed phase II trials. PMID:16044668

Evangelista, Stefano

2005-07-01

4

S-1360 Shionogi-GlaxoSmithKline.  

PubMed

Shionogi and GlaxoSmithKline, as the joint venture company Shionogi-GlaxoSmithKline Pharmaceuticals, is developing S-1360, an HIV integrase inhibitor as a potential treatment for HIV infection. As of October 2002, phase II trials were ongoing and launch is expected in 2004/2005. PMID:12669383

Billich, Andreas

2003-02-01

5

SB-480848. GlaxoSmithKline.  

PubMed

SB-480848 is a reversible lipoprotein-associated phospholipase A2 inhibitor under development by GlaxoSmithKline for the potential treatment of atherosclerosis. Phase II trials with SB-480848 are currently underway. PMID:15083604

Rotella, David P

2004-03-01

6

Alvimopan (Adolor/GlaxoSmithKline).  

PubMed

Alvimopan is a potent, peripherally active, mu-opioid receptor antagonist being developed by Adolor and GlaxoSmithKline (GSK) as a potential treatment for post-operative ileus and opioid bowel dysfunction. PMID:12431026

Azodo, Ijeoma A; Ehrenpreis, Eli D

2002-10-01

7

GW-501516 GlaxoSmithKline/Ligand.  

PubMed

GlaxoSmithKline and Ligand are developing GW-501516, a peroxisome proliferator-activator receptor-delta agonist for the potential treatment of dyslipidemia. Phase II clinical trials of this compound are ongoing. PMID:16625823

Pelton, Patricia

2006-04-01

8

Technology evaluation: mepolizumab, GlaxoSmithKline.  

PubMed

GlaxoSmithKline (formerly SmithKline Beecham) is developing mepolizumab (SB-240563), a monoclonal antibody directed against IL-5, as a potential treatment for asthma and atopic dermatitis. Phase II trials in asthma were underway by April 1998 and by March 2002, phase II trials had also been initiated in atopic dermatitis. PMID:12870444

Gnanakumaran, Gnanasegaram; Babu, K Suresh

2003-06-01

9

SB-277011 GlaxoSmithKline.  

PubMed

It is presumed that GlaxoSmithKline has taken over from SmithKline Beecham in investigating the highly selective dopamine D3 antagonist SB-277011 and its analogs for the potential treatment of schizophrenia [284490] following the merger of Glaxo Wellcome and SmithKline Beecham in December 2000 [394715]. In June 2000, it was reported that novel 2,3,4,5-tetrahydro-1H-benzazepines and 2,3-dihydro-1H-isoindoles, including SB-277011, had shown high affinity and selectivity for the dopamine D3 receptor. All compounds were suggested to have further potential roles in the treatment of drug abuse and psychosis [372205]. In November 2000, data presented at the 30th Neuroscience meeting in New Orleans, LA, demonstrated that D3 receptor blockade with SB-277011 specifically altered neurochemical effects in the nucleus accumbens without the non-selective effects, such as catalepsy, seen with some other antagonists [390460]. PMID:11757796

Remington, G; Kapur, S

2001-07-01

10

Rotavirus vaccine AVANT/GlaxoSmithKline.  

PubMed

AVANT Immunotherapeutics (formerly Virus Research Institute) and GlaxoSmithKline are developing a live oral rotavirus vaccine with potential to elicit a broadly-protective immune response against the most prevalent strains of rotavirus. Following successful completion of a phase II clinical efficacy trial in June 1999, SmithKline Beecham (now GlaxoSmithKline) assumed responsibility for all subsequent clinical and other development activities [328635], [333677]. Following a licensing agreement, the vaccine was refined and renamed RIX-4414 [371713]. In May 2000, AVANT reported the results of a second-year surveillance extension of the phase II study. The results suggested that AVANT's two-dose oral rotavirus vaccine should be helpful in preventing rotavirus gastroenteritis (RGE) disease in young children for at least two years following administration [365202]. In March 2000, SmithKline Beecham reported that it had initiated phase I/II bridging studies in Europe and the company planned to start phase III safety and efficacy studies in 2001 after review with the health authorities [358963]. In October 2000, Dain Rauscher Wessels stated that an estimated market penetration of 30 to 40% suggested potential sales in excess of US $500 million pa. As a result, the analysts also estimated that incremental revenues to AVANT could be over US $50 million pa [411122]. PMID:11757786

Jones, T

2001-07-01

11

Fosamprenavir. Vertex Pharmaceuticals/GlaxoSmithKline.  

PubMed

Fosamprenavir, a Vertex Pharmaceuticals phosphate ester prodrug of the HIV protease inhibitor amprenavir, is under development by GlaxoSmithKline (GSK; formerly Glaxo Wellcome) for the potential treatment of HIV infection in adults and children. By November 2000, it was in phase III trials; a third phase III trial was initiated in April 2001. In October 2001, GSK expected filing in both the EU and US in 2002. In January 2002, Vertex anticipated an NDA filing during the second half of 2002. Fast-track status for fosamprenavir was received by Glaxo Wellcome in December 1999. As of January 2002, enrollment was complete for two of the three phase III trials, and an NDA was expected to be filed during 2002. Fosamprenavir was first synthesized at Vertex as part of a collaboration with Glaxo Wellcome and by 1999, it was being developed by Glaxo Wellcome as part of an ongoing agreement between the two companies. In September 2000 and January 2001, Merrill Lynch predicted a 2002 launch, with sales of pounds sterling 50 million in 2002, rising to pounds sterling 150 million in 2004. PMID:12054084

Corbett, Amanda H; Kashuba, Angela D M

2002-03-01

12

Bexxar (Corixa/GlaxoSmithKline).  

PubMed

Bexxar (131I tositumomab) is a radiolabeled anti-CD20 monoclonal antibody for the treatment of relapsed and refractory follicular/low-grade and transformed non-Hodgkin's lymphoma. It has shown high response rates with durable complete remissions in patients who have received either prior chemotherapy or rituximab (Rituxan, MabThera; IDEC Pharmaceuticals Corp/Genentech/F Hoffmann La Roche). Complications include myelosuppression, secondary acute leukemia, myelodysplasia and hypothyroidism. The role of this promising new agent is being defined in phase II and III trials. In February 2001, ABN Amro Predicted launch in 2001 and sales of US $25 million rising to US $70 million in 2003 [422363]. Corixa and GlaxoSmithKline anticipate a launch in the US in 2002 [424619]. PMID:12054068

Cheson, Bruce

2002-01-01

13

Technology evaluation: SB-485232, GlaxoSmithKline.  

PubMed

GlaxoSmithKline (formerly SmithKline Beecham), under license from Hayashibara, is developing SB-485232, a recombinant human interleukin-18 cancer immunotherapy for the potential treatment of immunologically sensitive cancers, including melanoma and renal cell cancer. The compound is currently undergoing phase II clinical trials. PMID:15732534

Golab, Jakub; Stoklosa, Tomasz

2005-02-01

14

Sitamaquine (GlaxoSmithKline/Walter Reed Army Institute).  

PubMed

Sitamaquine (WR-6026) is an orally active 8-aminoquinoline analog in development by the Walter Reed Army Institute, in collaboration with GlaxoSmithKline (formerly SmithKline Beecham), for the potential treatment of visceral leishmaniasis. Phase III trials for the treatment of visceral leishmaniasis had been initiated by March 2002, at which time GlaxoSmithKline hoped to file an MAA in 2003. By 1999, the compound had also undergone phase I trials in HIV-infected individuals for the treatment of Pneumocystis carinii infection. Preclinical studies have been conducted in primates and rodents for the potential treatment of Babesia microti infection. PMID:12431016

Yeates, Clive

2002-10-01

15

AWD-12-281 (inhaled) (elbion/GlaxoSmithKline).  

PubMed

elbion (formerly ASTA Medica) and GlaxoSmithKline are developing an inhaled formulation of AWD-12-281 for the potential treatment of chronic obstructive pulmonary disease (COPD). By May 2005, phase II trials of this 5-hydroxyindole PDE4 inhibitor for COPD were ongoing. PMID:16312137

Gutke, Hans-Jürgen; Guse, Jan-Hinrich; Khobzaoui, Moussa; Renukappa-Gutke, Thejavathi; Burnet, Michael

2005-11-01

16

Lp-PLA2 inhibitors (GlaxoSmithKline).  

PubMed

GlaxoSmithKline is investigating a series of substituted pyrimidin-4-ones, including SB-435495, as reversible inhibitors of lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) for the potential treatment of atherosclerosis [339220], [422380]. This series is being developed alongside a series of irreversible inhibitors such as SB-222657 and derivatives of SB-253514 [339220], [401355]. SB-435495 was discovered through the use of gene technology provided by Human Genome Sciences (HGS) [400047]. By October 2001, phase II trials of SB-435495 had been initiated [424613]. PMID:15957087

Booker, M L

2001-10-01

17

HPV vaccine MedImmune/GlaxoSmithKline.  

PubMed

MedImmune, in collaboration with GlaxoSmithKline, is developing a vaccine consisting of self-assembling, virus-like particles for the prevention of human papillomavirus (HPV) infection of the genital tract and associated cervical cancer. The vaccine candidates include the prototype vaccine, MEDI-501 (a vaccine directed against HPV-11), MEDI-503 (directed against HPV-16) and MEDI-504 (directed against HPV-18). Following phase I studies, the HPV-16 and HPV-18 components were combined into a multivalent vaccine for subsequent trials; this vaccine is known as MEDI-517. Phase II trials of MEDI-517 were initiated by January 2000 and are currently ongoing. PMID:12669384

Billich, Andreas

2003-02-01

18

Repifermin. Human Genome Sciences/GlaxoSmithKline.  

PubMed

Human Genome Sciences (HGS) and GlaxoSmithKline (formerly SmithKline Beecham) are developing topical and injectable formulations of repifermin, keratinocyte growth factor-2 (KGF-2), also known as fibroblast growth factor-10 (FGF-10) for the potential treatment of wound care, oral and intestinal mucositis, and inflammatory bowel diseases [385959,396786]. A phase IIb trial of the topical formulation in chronic venous ulcers is ongoing, as well as phase II trials for the systemic, injectable formulation in ulcerative colitis and in the prevention of mucositis after chemotherapy with bone marrow transplantation [352908,368013, 385959,404294]. In May 2001, UBS Warburg predicted that HGS would receive approval of repifermin for the treatment of venous ulcers by yearend 2004, mucositis in 2005, and ulcerative colitis in the second half of 2004 [412015]. In October 2000, SmithKline Beecham exercised an option to codevelop repifermin for phase III trials and beyond [385959,399183]. In May 2001, UBS Warburg valued repifermin's worldwide market at 2 billion dollars for treating venous ulcers and predicted sales of 33 million dollars in 2004 and 118 million dollars in 2005 for this indication. In addition, the analysts regarded repifermin as having potential in the treatment of diabetic foot ulcers and pressure ulcers (a market valued at over 1.8 billion dollars) and estimated that the drug might earn another 103.5 million dollars for these indications in 2005. Furthermore, the analysts predicted sales of 6.8 million dollars for repifermin's mucositis indication and, for ulcerative colitis, sales of 27.3 million dollars in 2004 and 54.8 million dollars in 2005. Overall, the analysts estimated that repifermin represented a 3.5 billion dollars market opportunity for HGS/ GlaxoSmthKline and that commercialization of the drug might earn more than 61 million dollars by 2004 [412015]. PMID:15995938

Wheeler, G

2001-07-01

19

Rotavirus vaccine--AVANT immunotherapeutics/GlaxoSmithKline: 89-12, RIX4414.  

PubMed

GlaxoSmithKline is developing a two-dose, oral rotavirus vaccine [Rotarix] under a licensing agreement with AVANT Immunotherapeutics. Rotarix is a live attenuated human rotavirus strain, which was developed by AVANT in collaboration with the JN Gamble Institute of Medical Research in the US. Originally, the research partner for the JN Gamble Institute was the Virus Research Institute, but the latter company merged with T Cell Sciences in August 1998 to form AVANT Immunotherapeutics. In 1997, AVANT signed an agreement with SmithKline Beecham (now GSK) for collaboration in the development of Rotarix. In December 2000 SmithKline Beecham merged with Glaxo Wellcome to form GlaxoSmithKline (GSK). The agreement grants GlaxoSmithKline exclusive worldwide marketing rights to the vaccine in exchange for royalties, licence fees and milestone payments to AVANT. Under the agreement, GlaxoSmithKline assumed all responsibilities for the development and manufacture of the vaccine following the successful completion of the US phase II study of Rotarix, for which AVANT received a milestone payment from GlaxoSmithKline. PMID:15293874

2004-01-01

20

GlaxoSmithKline Inc. 5 Moore Drive Research Triangle Park ...  

Center for Biologics Evaluation and Research (CBER)

Text VersionPage 1. 1 GlaxoSmithKline Inc. 5 Moore Drive Research Triangle Park, NC 27709 ANORO™ ELLIPTA™ (Umeclidinium ... More results from www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials

21

78 FR 63226 - GlaxoSmithKline LLC; Withdrawal of Approval of the Indication for Treatment of Patients With...  

Federal Register 2010, 2011, 2012, 2013

...Drug Administration [Docket No. FDA-2013-N-1137] GlaxoSmithKline LLC; Withdrawal of Approval of the Indication for Treatment...tositumomab and iodine I 131 tositumomab) Injection held by GlaxoSmithKline LLP, P.O. Box 5089, 1250 South Collegeville...

2013-10-23

22

Scientists in Sport, the 2012-Inspired GlaxoSmithKline Schools Outreach Programme  

ERIC Educational Resources Information Center

|The GlaxoSmithKline Scientists in Sport team have worked with 4science to provide resources and offer activities for use by schools to show the relevance of science in sport. Much of the content looks at anti-doping and the science involved with detecting the misuse of banned substances. Through the development of a website, this work can…

Gadd, Mark

2012-01-01

23

Technology evaluation: mapatumumab, Human Genome Sciences/GlaxoSmithKline/Takeda.  

PubMed

Human Genome Sciences and GlaxoSmithKline, under license from Cambridge Antibody Technology, are developing mapatumumab, the intravenously administered lead from a series of human monoclonal antibody tumor necrosis factor-related apoptosis-inducing ligand receptor 1 agonists, for the potential treatment of cancer. The therapy is currently undergoing phase II clinical trials. Takeda is developing mapatumumab in Japan. PMID:16248286

Vulfovich, Michel; Saba, Nabil

2005-10-01

24

Belimumab Human Genome Sciences/Cambridge Antibody Technology/GlaxoSmithKline.  

PubMed

Belimumab, the lead in a series of human monoclonal antibodies against the human protein B-lymphocyte stimulator (BLyS), is under development by Human Genome Sciences, Cambridge Antibody Technology and GlaxoSmithKline for the potential treatment of autoimmune diseases, including systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). By January 2006, belimumab had completed phase II clinical trials in SLE and RA; a phase III clinical SLE trial is scheduled to begin later this year. PMID:16729724

Ding, Changhai; Jones, Graeme

2006-05-01

25

GlaxoSmithKline Adjuvant Systems in vaccines: concepts, achievements and perspectives.  

PubMed

The need for potentiating immune responses to recombinant or subunit antigens has prompted GlaxoSmithKline (GSK) Biologicals to develop various Adjuvant Systems for the design of prophylactic and therapeutic vaccines. Adjuvant Systems are formulations of classical adjuvants mixed with immunomodulators, specifically adapted to the antigen and the target population. They can activate the appropriate innate immune system and subsequently impact on adaptive immune responses. AS04 is an Adjuvant System that has demonstrated significant achievements in several vaccines against viral diseases. AS02, another Adjuvant System, is being evaluated in various contexts, where a strong T-cell response is needed to afford protection. Likewise, AS01 has been developed for vaccines where the induction of a yet stronger T-cell-mediated immune response is required. Altogether, the promising clinical results strongly support the concept of Adjuvant Systems and allow for further development of new vaccines, best adapted to the target population and the immune mechanisms of protection. PMID:17931153

Garçon, Nathalie; Chomez, Patrick; Van Mechelen, Marcelle

2007-10-01

26

Two decades of commitment to malaria vaccine development: GlaxoSmithKline Biologicals.  

PubMed

GlaxoSmithKline Biologicals (GSK) is committed to the development of a safe and effective malaria vaccine. Its research program in this field was initiated in 1984 and has been continuously active to this day, making it unparalleled within the vaccine industry. Although it works in partnerships with several leading organizations from the public sector, this effort has required GSK to invest major financial and human resource commitments, and its partners rely heavily on the company's global infrastructure and expertise in research, advanced clinical development, regulatory, large-scale manufacturing, and commercialization. Through GSK's pioneering business model and working in partnership with global vaccine funding agencies, the company is committed to seeing that, once approved, a safe and effective malaria vaccine will be available to everyone that needs it. PMID:18165505

Ballou, W Ripley; Cahill, Conor P

2007-12-01

27

Mepolizumab: 240563, anti-IL-5 monoclonal antibody - GlaxoSmithKline, anti-interleukin-5 monoclonal antibody - GlaxoSmithKline, SB 240563.  

PubMed

Mepolizumab is an anti-interleukin-5 monoclonal antibody that is in clinical trials with GlaxoSmithKline (GSK) for the treatment of severe asthma, nasal polyposis and hypereosinophilic syndrome and eosinophilic oesophagitis (the latter two indications are classed as eosinophilia in the phase table). Interleukin-5 stimulates the production, activation and maturation of eosinophils. Since mepolizumab inhibits interleukin-5 and has a long terminal half-life, treatment with mepolizumab causes a sustained reduction in the numbers of circulating eosinophils. Thus, mepolizumab may be a useful therapeutic agent for the treatment of conditions characterized by increased levels of eosinophils. Hypereosinophilic syndrome is a rare idiopathic disease with broad clinical signs and symptoms that is diagnosed based on a persistent blood eosinophil count of >1500 cells, various end-organ damages (including skin, heart, lung, nervous system and digestive system), and with exclusion of known secondary causes of hypereosinophilia. Mepolizumab is in clinical trials for the treatment of hypereosinophilic syndrome, eosinophilc oesophagitis, severe asthma (in patients with airway eosinophilia) and nasal polyposis. GlaxoSmithKline (GSK) has completed enrolment in a phase II study of mepolizumab in 20 patients with symptomatic eosinophilic bronchitis with or without asthma in Canada. The randomized, double-blind, placebo-controlled study is evaluating the effects of intravenous mepolizumab on asthma control, airway eosinophilia and the degree to which concomitant corticosteroid treatment can be reduced (NCT00292877). In previous clinical studies, including trials in the EU and US, mepolizumab has shown a lack of effect on allergen-induced airway responses and inflammation despite a significant reduction in blood and sputum eosinophil levels.A randomized, double-blind, placebo-controlled, multicentre, phase III study of mepolizumab over 9 months in 85 patients with hypereosinophilic syndrome was completed in 2006. All patients have been offered, and continued in, a phase III, open-label, long-term extension study of mepolizumab. Enrolment in this study was completed in September 2006.A phase III, compassionate use trial of mepalizumab (NCT00244686) in patients with hypereosinophilic syndrome was ongoing in October 2007 in the US. Patients who have significant clinical disease but are unresponsive to traditional treatment and those who have demonstrated clinical benefit from previous anti-IL-5 treatment are eligible to take part in the trial. Mepolizumab received orphan drug status for first-line treatment in patients with hypereosinophilic syndrome in the US and the EU in 2004. Mepolizumab is also in phase I/II clinical development for the treatment of eosinophilic oesophagitis. A phase I/II trial (NCT00358449) began in August 2006 in the US, Australia, the UK and Canada, and will enrol approximately 72 paediatric patients with eosinophilic oesophagitis. The randomized, parallel-group clinical trial will evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of intravenous mepolizumab for 12 weeks. In September 2006, GSK completed enrolment in a phase I/II study of mepolizumab for the treatment of eosinophilic oesophagitis in ten adult patients in Switzerland (NCT00274703). The randomized, double-blind, placebo-controlled study will evaluate the pharmacokinetics, pharmacodynamics, safety and tolerability of IV mepolizumab.A phase I/II trial of mepolizumab in four patients with eosinophilic oesophagitis conducted by Cincinnati Children's hospital found the monoclonal antibody was safe and effective. Brigham and Women's Hospital in association with GSK is conducting a phase I/II trial of mepolizumab in patients with Churg-Strauss Syndrome (CSS) in the US. The trial, which started in September 2007, will evaluate the potential of mepolizumab to reduce the need for corticosteroid therapy in patients with CSS (NCT00527566). CSS, otherwise known as allergic granulomatosis, is defined by patients with asthma, eosinophilia and vascul

2008-01-01

28

GlaxoSmithKline and Merck: private-sector collaboration for the elimination of lymphatic filariasis.  

PubMed

More than 1000 million people in 82 countries are at risk of contracting the tropical disease lymphatic filariasis (LF). Although the disease is wide-spread, transmission of the causative parasites can be stopped through mass drug administrations based on a combination of anti-parasitic medicines. For more than 10 years, the pharmaceutical companies GlaxoSmithKline (GSK) and Merck & Co., Inc., have participated in a unique private-sector collaboration to support the global efforts to eliminate LF, through donations of drugs to prevent the disease. GSK's albendazole and Merck's ivermectin (Mectizan) now reach hundreds of millions of people each year, through national LF-elimination programmes carried out in collaboration with Ministries of Health, the World Health Organization, non-governmental organizations and local communities. Working in support of the Global Programme to Eliminate Lymphatic Filariasis, GSK and Merck not only provide donated medicines but also offer financial, programmatic and management expertise to support LF-elimination efforts worldwide. PMID:19843393

Gustavsen, K M; Bradley, M H; Wright, A L

2009-10-01

29

Ariflo (SmithKline Beecham plc).  

PubMed

Ariflo (SB-207499) is a phosphodiesterase (PDE)4 inhibitor under development by SmithKline Beecham and in phase III and II clinical trials as a potential treatment for chronic obstructive pulmonary disease (COPD) and asthma, respectively [284490]. It has commenced phase II trials as a treatment for bronchial asthma in Japan [248285,300145]. In February 1999, Merrill Lynch predicted that Ariflo would be launched by the end of 2000 or early 2001 with first year sales of UK pounds sterling 25 million rising to UK pounds sterling 175 million in 2003 [300257,314372]. In February 1999 ABN Amro predicted sales of UK pounds sterling 52 million in 2001 rising to UK pounds sterling 254 million in 2005 [317577,328676]. PMID:16121306

Brown, W

1999-09-01

30

Review of Responses Submitted by GlaxoSmithKline ...  

Center for Biologics Evaluation and Research (CBER)

... comments on the response to the item. The inspection team consists of Jonathan McInnis and Pete Amin. Observation 1. ... More results from www.fda.gov/biologicsbloodvaccines/vaccines/approvedproducts

31

GlaxoSmithKline 4/19/10  

Center for Drug Evaluation (CDER)

... A multicenter, global surveillance program tested clinical isolates including pathogens ... susceptibility did not correlate with clinical success rates in ... More results from www.fda.gov/drugs/guidancecomplianceregulatoryinformation/enforcementactivitiesbyfda

32

Feasibility Study of GlaxoSmithKline Biologicals' GSK2202083A Vaccine in Healthy Infants at 3, 5 and 11 Months of Age.  

ClinicalTrials.gov

Haemophilus Influenzae Type b; Poliomyelitis; Hepatitis B; Serogroup C Meningococcal Diseases; Diphtheria; Pertussis; Diphtheria-Tetanus-aPertussis-Hepatitis B-Poliomyelitis-Haemophilus Influenzae Type b-Neisseria Meningitidis Vaccines; Tetanus

2012-11-16

33

GlaxoSmithKline Award Lecture. The O-GlcNAc modification: three-dimensional structure, enzymology and the development of selective inhibitors to probe disease.  

PubMed

Carbohydrates, their structures and the enzymes responsible for their synthesis and degradation, offer numerous possibilities for the design and application of probes with which to study and treat disease. The intracellular dynamic O-GlcNAc (O-linked ?-N-acetylglucosamine) modification is one such glycosylation with considerable medical interest, reflecting its implication in diseases such as Type 2 diabetes and neurodegeneration. In the present paper, we review recent structural and mechanistic studies into the enzymes responsible for this modification, highlighting how mechanism-inspired small-molecule probes may be applied to study potential disease processes. Such studies have questioned a causal link between O-GlcNAc and Type 2 diabetes, but do offer potential for the study, and perhaps the treatment, of tauopathies. PMID:20863281

Davies, Gideon J; Martinez-Fleites, Carlos

2010-10-01

34

June 14, 2012 Approval Letter - MenHibrix  

Center for Biologics Evaluation and Research (CBER)

... concomitantly with Rotarix (GlaxoSmithKline Biologicals), Pediarix (GlaxoSmithKline Biologicals) and Prevnar 13 (Pfizer) as compared to Pentacel ... More results from www.fda.gov/biologicsbloodvaccines/vaccines/approvedproducts

35

ARGATROBAN - argatroban injection, solution SmithKline ...  

Center for Biologics Evaluation and Research (CBER)

Text Version... One of the asymmetric carbons has an R configuration (stereoisomer Type I ... was based on a comparison of event rates for a composite endpoint that ... More results from www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials

36

Zanamivir (Glaxo Wellcome).  

PubMed

Zanamivir, a neuraminidase inhibitor under license from Biota, has been developed and launched by Glaxo Wellcome for the treatment of influenza virus infection [277127]. While registered as drugs, neuraminidase inhibitors are technically vaccines as they are believed to work by provoking an immune response, thus preventing the spread of infection from one cell to another within the respiratory tract [314356]. It is administered, using an inhaler, directly to where the virus replicates, minimizing the potential for side effects. Zanamivir has been launched, under the name Relenza, for the treatment of influenza in Australia [325148], New Zealand [335591] and the UK [341871]. It is registered in Mexico and Armenia [346474], and approved in Japan [351580]. In October 1999, it was launched in the US [352392] and Glaxo confirmed in January 2000, that zanamivir has been launched all over Europe, with the exception of Greece and Spain, where launch is imminent [352513]. In October 1999, the British Pharma Group (BPG) wrote to the UK Prime Minister to seek a discussion on the implications for the British-based pharmaceutical industry of the recommendation from NICE's Raised Appraisal Committee that Relenza should be banned from the NHS [342597]. An FDA submission was made in October 1998 [302732,304779]; the FDA advisory committee met on February 24 1999 to discuss the application [313583]. The Antivirals Drugs Advisory Committee voted against recommending zanamivir for FDA approval [316196]. Members suggested that additional studies using a different endpoint or targeting specific high-risk populations would be more likely to garner support [317454]. Following a discussion with Glaxo Wellcome in April 1999, the FDA indicated that it would continue to review the NDA for zanamivir [320565]. In July 1999, the company received final FDA approval for the drug for the treatment of both influenza A and B [334127], and aimed to initiate a phase IV trial program for the detection of consumer problems with the product, following launch of the product in time for the 1999-2000 flu season [352392,335048]. In September 1998, Glaxo applied to the Canadian Health Protection Branch (HPB) for approval to market zanamivir for the treatment and prevention of influenza. A separate application for Fast Track approval was also made with the HPB [299375,299472]. In November 1999, zanamivir received approval in Canada [346474]. Glaxo expects to make MAA and NDA filings for the use of zanamivir as a prophylactic in 1999 [333494]. In July 1998, Merrill Lynch predicted that as zanamivir offered only modest benefits gained from a narrow treatment window, potential would be limited and forecast annual sales of US dollar 30 million [302048]. In January 1999, Paribas predicted sales of pounds 75 million in 1999, rising to pounds 280 million in 2003 [317650]. In April 1999, ABN Amro predicted sales of pounds 23 million in 1999, rising to pounds 326 million in 2003 [328676]. In August 1999, Lehman Brothers estimated that sales of zanamivir will reach US dollar 400 million by 2003, and that it is an obvious candidate for an OTC switch, although this is not likely until 5 years after launch [336356]. PMID:16100701

Oxford, J S

2000-04-01

37

76 FR 19100 - Maria Carmen Palazzo: Debarment Order  

Federal Register 2010, 2011, 2012, 2013

...medical doctor with offices located in New Orleans, Louisiana. SmithKline Beecham, Corporation, d.b.a. GlaxoSmithKline (SKB) was a pharmaceutical company engaged in developing, testing, and marketing pharmaceutical products...

2011-04-06

38

Information for Healthcare Professionals Rosiglitazone ...  

Center for Drug Evaluation (CDER)

... products, all manufactured by GlaxoSmithKline, that contain rosiglitazone: Avandia, Avanadamet (rosiglitazone with metformin), and Avandaryl ... More results from www.fda.gov/drugs/drugsafety/postmarketdrugsafetyinformationforpatientsandproviders

39

Slides for the February 8, 2011 Meeting of the Oncologic ...  

Center for Biologics Evaluation and Research (CBER)

... GlaxoSmithKline. GSK Core and Backup Presentations, Bexxar (tositumomab and Iodine I 131 tositumomab), for the February 8, 2011 Meeting of ... More results from www.fda.gov/advisorycommittees/committeesmeetingmaterials/drugs

40

Pazopanib  

Microsoft Academic Search

In October 2009, pazopanib (Votrient; GlaxoSmithKline) — a multikinase inhibitor with targets that include vascular endothelial growth factor receptors — was approved by the US FDA for the treatment of advanced renal cell carcinoma.

Ronald M. Bukowski; Uma Yasothan; Peter Kirkpatrick

2010-01-01

41

DDMAC Letter: Adovart  

Center for Drug Evaluation (CDER)

Text Version... Michele M. Hardy Senior Director, US Regulatory Affairs, GlaxoSmithKline PO Box ... symptoms, • reduce the risk of acute urinary retention (AUR), and ... More results from www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation

42

December 4, 2012: Pediatric Oncology Subcommittee of the ...  

Center for Biologics Evaluation and Research (CBER)

... are: (1) Trametinib, application submitted by GlaxoSmithKline, LLC; (2) TH-302, application submitted by Threshold Pharmaceuticals, Inc.; (3 ... More results from www.fda.gov/advisorycommittees/calendar

43

Fast Track Approvals  

Center for Drug Evaluation (CDER)

... ditosylate), GlaxoSmithKline, 3/13/2007, Treatment-refractory (including Herceptin) advanced or metastatic ErbB2-overexpressing breast cancer. ... More results from www.fda.gov/drugs/developmentapprovalprocess/howdrugsaredevelopedandapproved

44

July 13–14, 2010: Joint Meeting of the Endocrinologic and ...  

Center for Biologics Evaluation and Research (CBER)

... On both days, the committees will focus primarily on the cardiovascular safety of AVANDIA (rosiglitazone maleate) Tablets, GlaxoSmithKline, a drug ... More results from www.fda.gov/advisorycommittees/calendar

45

21548 AND 22116 Fosamprenavir Written Request  

Center for Drug Evaluation (CDER)

Text Version... GlaxoSmithKline Attention: Anne Stokely, MSPH Director, Antiviral/Anti-infective Regulatory ... IND 58,627 for GW433908 for treatment of HIV disease. ... More results from www.fda.gov/downloads/drugs/developmentapprovalprocess

46

Review of Pertussis Clinical Serology - Rotarix  

Center for Biologics Evaluation and Research (CBER)

... Product: Rotarix®, GlaxoSmithKline (GSK) Rotavirus vaccine, live, oral, monovalent. ... IgG Antibody to Bordetella pertussis Outer Membrane Protein ... More results from www.fda.gov/biologicsbloodvaccines/vaccines/approvedproducts

47

Attention Healthcare Professional: FLOVENT® ROTADISK® ...  

Center for Drug Evaluation (CDER)

Text Version... GlaxoSmithKline has decided to phase out FLOVENT ROTADISK based on a careful assessment of the product's current manufacturing process ... More results from www.fda.gov/downloads/drugs/drugsafety

48

76 FR 59141 - Determination That LOXITANE (Loxapine Succinate) Capsules and Three Other Drug Products Were Not...  

Federal Register 2010, 2011, 2012, 2013

...mg base, EQ 25 mg base, and EQ 50 mg base. NDA 020403.................. ZOFRAN AND DEXTROSE GlaxoSmithKline, 5 IN PLASTIC Moore Dr., P.O. Box CONTAINER 13398, Research (ondansetron Triangle Park, NC...

2011-09-23

49

Briefing Information for the December 1, 2010 Meeting of the ...  

Center for Biologics Evaluation and Research (CBER)

... GlaxoSmithKline. Disclaimer. The statements contained in this document(s) are those of the product's sponsor, not FDA, and FDA does not ... More results from www.fda.gov/advisorycommittees/committeesmeetingmaterials/drugs

50

Preventing Tetanus, Diphtheria, and Pertussis Among Adolescents: Use of Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccines. Recommendations of the Advisory Committee on Immunization Practices (ACIP). Morbidity and Mortality Weekly Report, Vol. 55, No. RR-3, March 24, 2006.  

National Technical Information Service (NTIS)

During spring 2005, two tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine (Tdap) products formulated for use in adolescents (and, for one product, use in adults) were licensed in the United States (BOOSTRIX, GlaxoSmithKline Biologi...

2006-01-01

51

Antiretroviral Drugs Used in the Treatment of HIV Infection  

MedlinePLUS

... months Retrovir zidovudine, azidothymidine, AZT, ZDV GlaxoSmithKline 19-Mar-87 3.5 months Trizivir abacavir, zidovudine, and ... XR (Extended Release) nevirapine, NVP Boehringer Ingelheim 25-Mar-11 9.9 months Protease Inhibitors (PIs) Brand ...

52

July 7, 2003 Approval Letter - Infanrix  

Center for Biologics Evaluation and Research (CBER)

... Johan Van Hoof, MD GlaxoSmithKline Biologicals 89, Rue de l'Institut B-1330 Rixensart BELGIUM. Dear Dr. Van Hoof: ... More results from www.fda.gov/biologicsbloodvaccines/vaccines/approvedproducts

53

Letter - Study Hib-097 Review - Hiberix  

Center for Biologics Evaluation and Research (CBER)

... GlaxoSmithKline Biologicals, SA Attention: Elisa Harkins Associate Director North American Regulatory Affairs - Vaccines 2301 Renaissance Blvd. ... More results from www.fda.gov/biologicsbloodvaccines/vaccines/approvedproducts

54

Catherine K. Clark Director, US Regulatory Affairs ...  

Center for Drug Evaluation (CDER)

Text Version... Catherine K. Clark Director, US Regulatory Affairs GlaxoSmithKline One Franklin Plaza, PO Box 7929 Philadelphia, PA 19101 ... Catherine K. Clark ... More results from www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation

55

Vaccines and Related Biological Products Advisory: Cervarix ...  

Center for Biologics Evaluation and Research (CBER)

Text Version... Cervarix ® : Human Papillomavirus Bivalent (Types 16 and 18) Vaccine, Recombinant. Applicant: GlaxoSmithKline Biologicals (GSK). ... More results from www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials

56

FAMA for Zoster Studies Memo - MenHibrix  

Center for Biologics Evaluation and Research (CBER)

... Ph.D. Robin Levis, Ph.D. From: Shuang Tang, Ph.D. CC: Joseph ... GlaxoSmithKline (GSK) Biologicals requests approval of a candidate vaccine “ ... More results from www.fda.gov/biologicsbloodvaccines/vaccines/approvedproducts

57

Dear Health Care Provider Letter: Dosage And Administration ...  

Center for Biologics Evaluation and Research (CBER)

Text VersionPage 1. GlaxoSmithKline PO Box 13398 Five Moore Drive Research Triangle Park North Carolina 27709 Tel. 919 483 2100 www.gsk.com ... More results from www.fda.gov/downloads/biologicsbloodvaccines/safetyavailability

58

Pazopanib  

Center for Drug Evaluation (CDER)

... On April 26, 2012, the US Food and Drug Administration approved pazopanib tablets (VOTRIENT, a registered Trademark of GlaxoSmithKline) for ... More results from www.fda.gov/drugs/informationondrugs/approveddrugs

59

March 12, 2012 Approval Letter- Boostrix  

Center for Biologics Evaluation and Research (CBER)

... Boostrix. -. March 12, 2012 Approval Letter- Boostrix. GlaxoSmithKline Biologicals. Attention: Patrick J. Thomas. 2301 Renaissance Boulevard. ... More results from www.fda.gov/biologicsbloodvaccines/vaccines/approvedproducts

60

William Smith  

USGS Multimedia Gallery

William Smith(1769-1839) is Considered by many people to be the "Father of English Geology". He began his work as an engineer for a company digging canals. While he was working he made some observations about the way that the Earth was arranged in layers around him. This lead to him creating a profi...

2009-07-22

61

Joseph Smith the Prophet  

NSDL National Science Digital Library

Just a quick look at the Prophet Joseph Smith\\'s life and all that he accomplished. As you go to the site below think of the following questions: What do you think was the greatest contribution the Prophet Joseph Smith made? What can you do today to show him your appreciation and to keep the work moving forward? Key Events in the Life of Joseph Smith While looking through the church sites ask yourself the following question: Which ...

Carter, Mr. S.

2006-10-23

62

Natural product source material use in the pharmaceutical industry: the Glaxo experience  

Microsoft Academic Search

Glaxo PLC has had a significant involvement with Natural Product Source Materials for all of its commercial history and, most recently, has pursued this interest by use of such materials as templates for new lead discovery. Through the expertise and facilities in its Natural Products Discovery Department, Glaxo extracts relatively small quantities of plant material (typically 200–250 g dry weight)

David M. Turner

1996-01-01

63

The Adam Smith Page  

NSDL National Science Digital Library

Edward J. Harpham, Associate Professor of Government and Political Economy at the University of Texas at Dallas, developed this new site to promote the study of the moral, political, and economic ideas of Adam Smith. Anyone with an interest in Smith's ideas will find numerous resources of interest. Perhaps the most useful are Harpham's updated lists of new and forthcoming scholarly articles and books on Smith. Students will also benefit from the comprehensive bibliography of secondary works, brief commentaries on Smith's works, and the collection of related links.

Harpham, Edward J.

1998-01-01

64

Adam Smith and Isaac Newton  

Microsoft Academic Search

The commonly held view that Adam Smith patterned economics after Issac Newton's method is examined and dismissed. Both Smith and Newton's methods are explored and compared. Smith's method is shown to have differed significantly from Newton's--in spite of Smith's pronouncements to the contrary--for reasons best explained by considering the Scottish tradition. Finally, the significance of Smith's methodology for modern economics

Deborah A. Redman

1993-01-01

65

Smith Tackles Oakland Unified  

ERIC Educational Resources Information Center

|As a 20-something, Anthony "Tony" Smith had fulfilled one dream: playing professional football for the Green Bay Packers and the San Francisco 49ers. Next up, he thought, was law school, but a former mentor reminded him that he is a teacher. Smith never became a classroom teacher, but his background in sports--where he learned the power of…

Mellon, Ericka

2011-01-01

66

k-line iterative methods: a conjugate-gradient approach  

SciTech Connect

The generalized conjugate gradient scheme based on the k-line block Jacobi splitting A = M-N was studied for solving model two-dimensional parabolic and elliptic difference equations AU = F tilde. A represents the matrix ch/sup ..cap alpha../-h/sup 2/..delta../sub h/. Eigenvalues of M/sup -1/N cluster, and the cluster radii decrease as ch/sup ..cap alpha../ or k increases. Computations with k = 4, 8, 16, 32, and ch/sup ..cap alpha../ = 0, h, 2 are discussed.

Kratzer, D.; Parter, S.V.; Steuerwalt, M.

1981-03-29

67

European Respiratory Society (ERS) - 20th Annual Congress.  

PubMed

The European Respiratory Society Congress, held in Barcelona, included topics covering new therapeutic developments in the field of respiratory health and disease. This conference report highlights selected presentations on therapies targeting inflammatory cells, with a focus on therapeutic agents for asthma and COPD. This report also includes a discussion of novel therapeutic agents for pulmonary hypertension. Investigational drugs discussed include OC-000459 (Oxagen), SCH-527123 (Merck & Co), AZD-9668 (AstraZeneca), benralizumab (MedImmune/Kyowa Hakko Kirin/BioWa), PF-3429281 (Pfizer), vilanterol (GlaxoSmithKline/Theravance), LAS-100977 (Almirall Prodesfarma), selexipag (Nippon Shinyaku/Actelion) and GW-0742 (GlaxoSmithKline). PMID:21046521

Seale, John Paul

2010-11-01

68

The Relevance of Adam Smith  

NSDL National Science Digital Library

The Federal Reserve Bank of Richmond explores the relevance of eighteenth-century economist Adam Smith in today's world. Quoting heavily from Smith's famous work The Wealth of Nations, this article summarizes many of Smith's main themes and ideas, and attempts to prove that Smith's "ideas have become so thoroughly absorbed into our intellectual heritage that they are no longer identifiable as having originated with Adam Smith."

69

Stephen Jay Kline on systems, or physics, complex systems, and the gap between.  

SciTech Connect

At the end of his life, Stephen Jay Kline, longtime professor of mechanical engineering at Stanford University, completed a book on how to address complex systems. The title of the book is 'Conceptual Foundations of Multi-Disciplinary Thinking' (1995), but the topic of the book is systems. Kline first establishes certain limits that are characteristic of our conscious minds. Kline then establishes a complexity measure for systems and uses that complexity measure to develop a hierarchy of systems. Kline then argues that our minds, due to their characteristic limitations, are unable to model the complex systems in that hierarchy. Computers are of no help to us here. Our attempts at modeling these complex systems are based on the way we successfully model some simple systems, in particular, 'inert, naturally-occurring' objects and processes, such as what is the focus of physics. But complex systems overwhelm such attempts. As a result, the best we can do in working with these complex systems is to use a heuristic, what Kline calls the 'Guideline for Complex Systems.' Kline documents the problems that have developed due to 'oversimple' system models and from the inappropriate application of a system model from one domain to another. One prominent such problem is the Procrustean attempt to make the disciplines that deal with complex systems be 'physics-like.' Physics deals with simple systems, not complex ones, using Kline's complexity measure. The models that physics has developed are inappropriate for complex systems. Kline documents a number of the wasteful and dangerous fallacies of this type.

Campbell, Philip LaRoche

2011-06-01

70

Influence of Photospheric Magnetism and Dynamics on Chromospheric K-line Emission  

Microsoft Academic Search

We analyze a unique 9 hr sequence of near simultaneous, high resolution and high cadence G-band and K-line SVST solar filtergrams together with magnetograms of lower cadence and resolution. We focus on a region of the solar surface that includes both internetwork and network. We examine how the (temperature minimum\\/chromospheric) CaII K-line and (photospheric) G-band intensities, their temporal fluctuations and

J. K. Lawrence; A. C. Cadavid; D. Miccolis; T. E. Berger; A. Ruzmaikin

2003-01-01

71

Rogers E. Smith  

NASA Website

After a distinguished career at NASA's Dryden Flight Research Center, Edwards, Calif, Rogers E. Smith retired at the end of September 2000 to pursue another career in consulting. At Dryden, he was the chief of the Flight Crew Branch for a number ...

72

ERP Modulation during Observation of Abstract Paintings by Franz Kline.  

PubMed

The aim of this study was to test the involvement of sensorimotor cortical circuits during the beholding of the static consequences of hand gestures devoid of any meaning.In order to verify this hypothesis we performed an EEG experiment presenting to participants images of abstract works of art with marked traces of brushstrokes. The EEG data were analyzed by using Event Related Potentials (ERPs). We aimed to demonstrate a direct involvement of sensorimotor cortical circuits during the beholding of these selected works of abstract art. The stimuli consisted of three different abstract black and white paintings by Franz Kline. Results verified our experimental hypothesis showing the activation of premotor and motor cortical areas during stimuli observation. In addition, abstract works of art observation elicited the activation of reward-related orbitofrontal areas, and cognitive categorization-related prefrontal areas. The cortical sensorimotor activation is a fundamental neurophysiological demonstration of the direct involvement of the cortical motor system in perception of static meaningless images belonging to abstract art. These results support the role of embodied simulation of artist's gestures in the perception of works of art. PMID:24130693

Sbriscia-Fioretti, Beatrice; Berchio, Cristina; Freedberg, David; Gallese, Vittorio; Umiltà, Maria Alessandra

2013-10-09

73

ERP Modulation during Observation of Abstract Paintings by Franz Kline  

PubMed Central

The aim of this study was to test the involvement of sensorimotor cortical circuits during the beholding of the static consequences of hand gestures devoid of any meaning.In order to verify this hypothesis we performed an EEG experiment presenting to participants images of abstract works of art with marked traces of brushstrokes. The EEG data were analyzed by using Event Related Potentials (ERPs). We aimed to demonstrate a direct involvement of sensorimotor cortical circuits during the beholding of these selected works of abstract art. The stimuli consisted of three different abstract black and white paintings by Franz Kline. Results verified our experimental hypothesis showing the activation of premotor and motor cortical areas during stimuli observation. In addition, abstract works of art observation elicited the activation of reward-related orbitofrontal areas, and cognitive categorization-related prefrontal areas. The cortical sensorimotor activation is a fundamental neurophysiological demonstration of the direct involvement of the cortical motor system in perception of static meaningless images belonging to abstract art. These results support the role of embodied simulation of artist’s gestures in the perception of works of art.

Sbriscia-Fioretti, Beatrice; Berchio, Cristina; Freedberg, David; Gallese, Vittorio; Umilta, Maria Alessandra

2013-01-01

74

FTC Advertising Substantiation Program. Cold Remedies and Cough Medicines. Documentation of Smith, Kline and French Lab. (Menley and James, Ltd.).  

National Technical Information Service (NTIS)

The report consists of documentation submitted in support of claims that C-3 provides effective relief from cold symptoms and coughs for up to 12 hours, can prevent a cough or cold from spreading to the other members of one's family; that a summer cold is...

1972-01-01

75

Sophia Smith Collection  

NSDL National Science Digital Library

As part of the Five College Archives Digital Access Project (mentioned in the September 25, 1998 Scout Report), Smith College has digitized some of its archival holdings relating to women's history. The Website of the Sophia Smith Collection presents still more of the Smith College holdingsof "manuscripts, photographs, periodicals and other primary sources in women's history." The site includes brief descriptions of over 300 manuscript collections, lesson plans for using primary source materials, links to additional women's history resources, and selected digital images. A permanent exhibition, Agents of Social Change, showcases some materials online. The exhibit contains pictures and digitized documents on eight 20th-century women and organizations working for women's rights. Visitors will find items such as a brochure about the National Congress of Neighborhood Women (NCNW), a grassroots feminist organization; a 1980 photo of an NCNW march on New York City Hall; Gloria Steinem photographed at the Ms. office in 1983; and fan mail to Steinem after a TV appearance.

1997-01-01

76

Vertebrate remains from excavations at the Glaxo-Wellcome factory premises, Ware, Hertfordshire  

Microsoft Academic Search

Summary Excavations at numerous sites in the vicinity of the Glaxo-Wellcome factory produced small assemblages of animal bone. Although most of the material is of limited interpretative value, several points are worthy of note. The presence of burnt cattle mandibles complements evidence from the late Roman waterfront sites in Lincoln where a large proportion of cattle jaws had been deliberately

Deborah Jaques; Keith Dobney

1996-01-01

77

HPV - a vaccine against cervical cancer  

Microsoft Academic Search

Most cervical cancer is caused by Human papillomavirus (HPV). Protection against the major cancer-causing serotypes of this virus by vaccination is now a reality for New Zealand women. Internationally two manufacturers have candidate HPV vaccines: the bivalent Cervarix (GlaxoSmith Kline) and the tetravalent Gardasil (CSL and Merck & Co). This article focuses on Gardasil, as this vaccine is now available

N. Desmond; H. Petousis-Harris; N. Turner

2006-01-01

78

Disconnected Youth in the Research Triangle Region: An Ominous Problem Hidden in Plain Sight  

ERIC Educational Resources Information Center

In September 2006, the North Carolina GlaxoSmithKline Foundation commissioned MDC, Inc. of Chapel Hill to analyze the problem of "disconnected youth" in the Research Triangle region, determine the current state of the region's responses to the challenge, and recommend steps to deepen and accelerate action on the issue. The research process was…

Dodson, David; Guillory, Ferrel; Lipsitz, Joan; Raper, Noah; Rausch, Christina

2008-01-01

79

77 FR 63839 - Vaccines and Related Biological Products Advisory Committee; Notice of Meeting  

Federal Register 2010, 2011, 2012, 2013

...committee will meet in open session to discuss and make recommendations on the safety and immunogenicity of an Influenza A (H5N1) Virus Monovalent Vaccine manufactured by GlaxoSmithKline. On November 15, 2012, the committee will meet in open...

2012-10-17

80

Field Testing of Bimetallic Nanoscale Particle Technology for In-Situ Groundwater Treatment of a Fractured Rock DNAPL Zone  

Microsoft Academic Search

This study has been carried out as part of the Corrective Measure Study (CMS) at a property owned by GlaxoSmithKline in Research Triangle Park, North Carolina, USA. The study area is located in the Durham subbasin of the Deep River Triassic Basin and is underlain by interbedded siltstone and sandstone sequences. Groundwater underlying portions of the site has been impacted

W. Zhang; L. Walata; R. Nash; F. Gheorghiu; R. Glazier; R. Venkatakrishnan

2003-01-01

81

Disconnected Youth in the Research Triangle Region: An Ominous Problem Hidden in Plain Sight  

ERIC Educational Resources Information Center

|In September 2006, the North Carolina GlaxoSmithKline Foundation commissioned MDC, Inc. of Chapel Hill to analyze the problem of "disconnected youth" in the Research Triangle region, determine the current state of the region's responses to the challenge, and recommend steps to deepen and accelerate action on the issue. The research process was…

Dodson, David; Guillory, Ferrel; Lipsitz, Joan; Raper, Noah; Rausch, Christina

2008-01-01

82

Important information for ARIXTRA® Starter Kit patients regarding Triad Group’s alcohol prep products  

NASA Website

GlaxoSmithKline (GSK) has become aware of a United States market recall of all lots of alcohol prep pads, swabs and swabsticks manufactured by the Triad Group and marketed under various brand names. The Triad Group recall has been initiated due to ...

83

Ezogabine (retigabine)  

Microsoft Academic Search

Ezogabine (Potiga; Valeant Pharmaceuticals\\/GlaxoSmithKline), a potassium channel opener, was approved in June 2011 by the US Food and Drug Administration (FDA) for the adjunctive treatment of partial-onset seizures in adult patients. The same drug was granted marketing authorization for this indication in the European Union in March 2011, where it is known as retigabine (Trobalt).

Carl E. Stafstrom; Seden Grippon; Peter Kirkpatrick

2011-01-01

84

Patient and Physician Partnerships in Managing Genital Herpes  

Microsoft Academic Search

2 GlaxoSmithKline Genital herpes simplex virus infections are widespread throughout the world and are char- acterized by stigma, myth, and anxiety by patients and the public but are perceived as trivial by most physicians. Surveys in the United States, Europe, Australia, and South Africa have measured the unfavorable effect of genital herpes on infected patients, health care resources, and workplace

Linda Alexander; Barbara Naisbett

2002-01-01

85

PowerPoint Presentation  

Cancer.gov

• Journal of the National Cancer Institute, ePub January 7, 2013; print: February, 2013 (issue 3) Disclosure • I am an inventor of NIH vaccine technology that has been licensed to Merck and GlaxoSmithKline, the two companies that manufacture the

86

Emerging Role of Weekly Topotecan in Recurrent Small Cell Lung Cancer  

Microsoft Academic Search

Small cell lung cancer (SCLC) is an aggressive tumor that often metastasizes before the primary can- cer is diagnosed. Patients with SCLC are typically elderly and often have comorbidities that may predis- pose them to adverse events during therapy. Although topotecan (Hycamtin ® ; GlaxoSmithKline; Philadelphia, PA), 1.5 mg\\/m 2

JOHN R. ECKARDT

87

Getting to know Joseph Smith  

NSDL National Science Digital Library

In these simple modules you will commit to memory 6 important dates in the life of Joseph Smith. Attempt to remember the date before clicking on the link directly under the picture. Write the dates in your journal and present the journal to Bro. Davidson for credit Joseph Smith was born in Sharon, Windsor county, Vermont in _____? Cute baby boy Birth date The first vision occurred in _____? first vision First vision date Moroni then visits the prophet in ____? Moroni Moroni visitations Joseph marries Emma ____? Emma Smith Marriage The church is officially reorganized in ____? Church restored Restoration Joseph and Hyrum martyred in ____? Martyrdom of Joseph Smith Martyrdom ...

Davidson, Bro.

2010-06-09

88

Task Force Smith: An Intelligence Failure.  

National Technical Information Service (NTIS)

This monograph examines intelligence and how it was applied to Task Force Smith. Task Force Smith was a regimental combat from 1st Battalion 21st Infantry Regiment commanded by Lieutenant Colonel Charles 'Brad' Smith, the first American soldiers committed...

R. E. Matthews

1995-01-01

89

Genetics Home Reference: Smith-Magenis syndrome  

MedlinePLUS

... PubMed Recent literature OMIM Genetic disorder catalog Conditions > Smith-Magenis syndrome On this page: Description Genetic changes ... names Glossary definitions Reviewed February 2007 What is Smith-Magenis syndrome? Smith-Magenis syndrome is a developmental ...

90

The Law and Mr. Smith  

Microsoft Academic Search

Here in jurisprudence made popular a distinguished law teacher comes to the defense of judges and lawyers. Mr. Smith, addressee of the book, is any layman. When in deciding a case about airplane flights the United States Supreme Court relies on a statute passed in 1790 and an English case of vintage 1773, Mr. Smith (so a blurb informs us)

Myres S. McDougal

1939-01-01

91

Droessler receives Smith Medal  

NASA Astrophysics Data System (ADS)

The Waldo E. Smith Medal for extraordinary service to geophysics was presented to Earl G. Droessler at the 1992 AGU Fall Meeting Honors Ceremony on December 9, 1992. The meeting was held in San Francisco. The award citation, delivered by Thomas Malone, as well as Droessler's response, are presented here.“With consummate wisdom, unfettered imagination, boundless enthusiasm, and gentle persuasion, Earl Droessler has been one of the prime movers in the elevation of geophysics to prominence in the scientific community during the second half of the 20th century. His contributions began [when he was] a key figure in the Geophysics Section of the Office of Naval Research in the 1940s, when ONR was pioneering in establishing productive links between the federal government and the university community.

Malone, Thomas; Droessler, Earl G.

92

Sophia Smith Collection: Women's History Archives at Smith College  

NSDL National Science Digital Library

The Sophia Smith Collection at Smith College was made possible under the guidance of its first director, Margaret Storrs Grierson. In 1946, it was named in honor of the founder of Smith College and it has grown to include over 650 different thematic collections. On this page, visitors can browse through their online image collections, oral histories, and exhibits. The oral histories are quite a treat, as they include 50 in-depth interviews which document the persistence and diversity of organizing for women in the United States. Additionally, this area contains interviews on population and reproductive health and conversations with student activists at Smith College. The Online Exhibits area includes nine thematic collections. One of the most interesting among them is the Girl Zines collection, which features independent magazines that address "third wave" feminism and sexuality. Finally, visitors can use the Finding Images section to look over 300 items that include political buttons, handicrafts, and cartoons.

2012-07-13

93

Adrienne Smith Long, Doctoral Fellow  

Cancer.gov

Adrienne Smith graduated summa cum laude from McCormick School of Engineering at Northwestern University in 2008 with a Bachelors of Science in Biomedical Engineering and matriculated into the Feinberg School of Medicine at Northwestern in 2008.

94

Comparisons of MgII core-wing data with Ground-Based Ca K-line  

NASA Astrophysics Data System (ADS)

Magnesium_II core-wing ratio data will be compared with ground-based K-line photometry for most of cycle 22 and 23. The ground-based data is the photmetric sum computed from the composite K-line obtained from the San Fernando Observatory. We will examine several MgII core-wing composites. This work is partially supported by grants NNX11AB51G from NASA and ATM-0848518 from NSF.

Chapman, G. A.; Preminger, D.

2011-12-01

95

Influence of Photospheric Magnetic Fields and Dynamics on Chromospheric K-Line Emission  

Microsoft Academic Search

We analyze a 9 hr sequence of simultaneous, high-resolution, high-cadence G-band and K-line solar filtergrams plus magnetograms of lower cadence and resolution. Images include both network and internetwork. The magnetic and filtergram intensities, their fluctuations, and relative phases change with progressive strengthening of local magnetic field. At increased flux levels, sudden photospheric downflows create long-lived magnetic elements. For weak magnetic

J. K. Lawrence; A. C. Cadavid; D. Miccolis; T. E. Berger; A. Ruzmaikin

2003-01-01

96

Carrington Maps of Ca II K-line Emission for the Years 1915-1985  

NASA Astrophysics Data System (ADS)

We have used Mount Wilson Observatory calcium K-line images, digitized and flat fielded by the solar group at UCLA, to construct Carrington maps of Ca II 3934 Å intensity for the years 1915-1985. These maps have a spatial resolution comparable to the resolution of Carrington maps of the magnetic field observed at Kitt Peak and a spectral resolution comparable to the width of the K232 emission. Consequently, they provide a way of tracking the spatial distribution of magnetic flux from the present back to the year 1915. In this paper, we compare some of the recent K-line maps with corresponding maps of magnetic field, and show examples of K-line maps during earlier sunspot cycles when high-quality magnetograms were not available. Then, we use butterfly diagrams and super-synoptic displays to summarize the long-term evolution of the patterns of calcium intensity. Although each cycle has characteristics that are similar to the others, cycle 19 is remarkable for its broad latitudinal distribution of active regions, for its giant poleward surges of flux, and for the emergence of a north-south asymmetry that lasted 10 years.

Sheeley, N. R., Jr.; Cooper, T. J.; Anderson, J. R. L.

2011-03-01

97

Cowboy Photographer: Erwin E. Smith  

NSDL National Science Digital Library

While many are familiar with the romantic notion of the American cowboy as crafted by Frederic Remington and Charles M. Russell, few share intimate knowledge of a lesser known artist, Erwin E. Smith. This online exhibit, created by the Amon Carter Museum in Texas, seeks to rectify that situation through this extensive archive of photographs by Smith that capture the world of the cowboy around the turn of the 20th century. Smith grew up in Texas collecting prints of paintings by artists like George Catlin and Frederic Remington. He later ended up studying art with Lorado Taft at the Art Institute of Chicago, and then at the School of the Boston Museum of Fine Arts. Smith later moved back West, and between 1905 and 1912, he took thousands of photographs on ranches throughout Texas, New Mexico, and Arizona. The photographs available online here are divided into several main sections for convenient browsing, including Cowhand clothing, Rodeo, and Ranches. Along with a biography of Smith, the site also includes a glossary of terms used by cowboys and ranchers, as well as several teaching resources for educators.

98

The Late Mr. Assheton Smith  

Microsoft Academic Search

THE man of ample means, and who is a lover of living creatures, has a great opportunity. Mr. Assheton Smith had this opportunity, and he used it not only to gratify his own pleasure, but to share it with others. There was nothing that he liked better than to go the round of his park with a guest, and to

Philip J. White

1904-01-01

99

Arthur Smith, Local Baptist Pastor.  

ERIC Educational Resources Information Center

Written and published by the students at Gary High School this volume has three articles dealing with East Texas life. The first "Arthur Smith" (David Hancock and others) is an account of growing up in Marian County, Texas is described by the local Baptist minister. The pastor begins with the year of his birth and gives detailed information about…

Heaton, Moss, Ed.

1985-01-01

100

Smith Mammal Body Mass Data  

NSDL National Science Digital Library

Data compiled on body mass information for 5731 mammalian species. Felisa A. Smith, S. Kathleen Lyons, S. K. Morgan Ernest, Kate E. Jones, Dawn M. Kaufman, Tamar Dayan, Pablo A. Marquet, James H. Brown, and John P. Haskell. 2003. Body mass of late Quaternary mammals. Ecology 84:3403

Ethel Stanley (Beloit College;Biology)

2009-01-10

101

La ideologización del pensamiento de Adam Smith  

Microsoft Academic Search

This paper examines the process of ideologization of Adam Smith’s thought. In The Wealth of Nations (1776), Smith embraced free enterprise as the foundational principle of nascent capitalism. The concept of the invisible hand –a metaphysical idea– helped give cohesion to a newborn science that offered a more dynamic and realistic explanation of the wealth of nations. The conceptual success

2009-01-01

102

Unity in the Influences on Adam Smith  

Microsoft Academic Search

Argues that the principal influences on Adam Smith stem from the same source, namely, Francis Hutcheson. This is true both of the religious and Stoic influences on Smith and also (indirectly) of the influence on him of David Hume. Concludes that it is unwise to ignore the role of Design and the benevolent Deity in Smith's system, or to neglect

Peter H. Clarke

103

Adam Smith’s Legacy for Ethics and Economics  

Microsoft Academic Search

This article challenges a popular understanding of the Wealth of Nations. According to this reading of Smith, self-interested, economic actors in free competition with each other unintentionally create a self-constraining system. This system, the “invisible hand” which governs market transactions, functions both to regulate these self-interests and to produce economic growth and well-being such that no one actor or group

P. H. Werhane

2006-01-01

104

Smith-McGuckin spot.  

PubMed Central

Direct inspection of the tympanic membrane, especially with the help of the microscope, continues to be an important part of the examination of the patient suffering from ear disease. Accurate assessment of the varied appearances can be helpful in anticipating the prognosis in SMOM and may give information about the pathology of CSOM and cholesteatoma. The Smith-McGuckin spot was first described 20 years ago (Smith 1964, R Thomas 1965, personal communication) and its significance is reviewed. Further evidence of the relationship between skeletal disorders such as Turner's syndrome and persistent SMOM is described. It is suggested that bone resorption in the deep meatus, outer attic wall and ossicles may result from chronic hyperaemia rather than sepsis or avascular necrosis. The part played by cholesteatoma in bone erosion is questioned. Images Figure 2. Figure 3. A Figure 3. B Figure 4. Figure 6. A Figure 6. B Figure 1. Figure 5. Figure 8. Figure 10. Figure 7. Figure 9.

Smith, C W

1985-01-01

105

Fukushima to receive Smith Medal  

NASA Astrophysics Data System (ADS)

The 1990 Waldo E. Smith Medal for extraordinary service to geophysics will be given to Naoshi Fukushima, who earned an international reputation for his pioneering work in geomagnetic disturbance and ionospheric electric currents. Now retired from the University of Tokyo, Japan, Fukushima is being cited for his public service to international geophysics, and, in particular, his contributions to the International Association of Geomagnetism and Aeronomy, of which he was Secretary General from September 1975 to August 1983.The Smith Medal will be presented as part of the AGU Fall Meeting Honors Night festivities, Wednesday, December 5, in San Francisco, Calif. Three James B. Macelwane Medals, the John Adam Fleming Medal, and the Maurice Ewing Medal will also be presented (see Eos, February 20, 1990, p. 294).

106

Street & Smith's Preservation Access Project  

NSDL National Science Digital Library

For thousands of Americans throughout the 19th and early 20th centuries, dime novels and pulp magazines were their first experiences with the emerging world of mass-produced material culture. One such purveyor was the Street & Smith publishing house, which began in 1855 and published a wide variety of popular literature (such as homemaking magazines, comics, and dime novels) for over 100 years. These products didn't often have a great deal of originality, as the company viewed fiction as a commodity, and editors dictated plots and characters to writers, a list that included Horatio Alger, Upton Sinclair, and Jack London. This Web site, an online exhibit presented by the Syracuse University Library, pays homage to this publishing house with a number of scanned digitized images of the Street & Smith dime novels, a cover art gallery, and a collection of images immortalizing that most famous comic strip character, the Yellow Kid.

107

William Smith (1769-1839)  

NSDL National Science Digital Library

This brief history of William Smith, who initiated the Principle of Faunal Succession, covers his early education, his employment as an assistant surveyor to Edward White, and his time as construction supervisor of the Somerset Canal in southwestern England. The text explains his production of a geological map of England and final recognition in 1831, when he received the Wollaston Medal, the highest honor awarded each year for outstanding achievement in geology by the Geological Society of London.

108

PIXE analysis of U and Pu from hot particles: K-lines vs L-lines  

NASA Astrophysics Data System (ADS)

Transuranic nuclides have been released into the environment since the beginning of the nuclear age. In many of the areas so contaminated, a significant fraction of the plutonium appears under the form of radioactive particles (also called 'hot' particles).In previous works, García López et al. (2007) [1] and Jiménez-Ramos et al. (2010) [2], radioactive particles from aircraft accidents in Palomares and Thule have been characterized. Using micro-Proton Induced X-ray Emission (?-PIXE) and confocal X-ray fluorescence microprobe (?-XRF), the L-lines of the main components in these particles, U and Pu, were analyzed.In this work, the key goal is the possibility to determine elemental ratios and concentration of transuranic elements in hot particles from the same areas but using their K-lines, because of their advantages in comparison with the study of L-lines. Indeed, the U and Pu K-lines present not overlapping between the main peaks in the spectra and the X-ray absorption in the sample is much lower than for L-lines.

Jiménez-Ramos, M. C.; García López, J.; Eriksson, M.; Jernstrom, J.; García-Tenorio, R.

2012-02-01

109

World Vaccine Congress Lyon - Terrapinn's 11th Annual Congress.  

PubMed

The 11th Annual World Vaccine Congress, held in Lyon, included topics covering new therapeutic developments in the field of vaccines. This conference report highlights selected presentations on the role of big pharma in vaccine development, the future direction of vaccine R&D, influenza preparedness in Europe, and vaccines for Staphylococcus aureus, CMV and cancer. Investigational drugs discussed include an H5N1 influenza vaccine program from Baxter International Inc/DynPort Vaccine Co LLC, FP-01 (Immune Targeting Systems Ltd), FluGEM (Mucosis BV), a nonstructural protein-1-altered live-attenuated influenza vaccine candidate from Vivaldi Biosciences Inc, PentaStaph (GlaxoSmithKline plc) and StaphVAX (Nabi Biopharmaceuticals), VCL-CB01 (Vical Inc) and astuprotimut-r (GlaxoSmithKline). PMID:19943212

Sovran, Liza

2009-12-01

110

Immunogenicity of Danish-SSI 1331 BCG vaccine in the UK: Comparison with Glaxo-Evans 1077 BCG vaccine  

Microsoft Academic Search

The immunogenicity and reactogenicity, in British schoolchildren, of the newly introduced Danish-SSI 1331 BCG vaccine was compared with that of the previously used Glaxo-Evans 1077 BCG vaccine. Interferon-gamma (IFN-?) response to M. tuberculosis purified protein derivative (M.tb PPD) in a 6-day whole blood assay and delayed type hypersensitivity (DTH) to tuberculin PPD were determined before and 1 year after receiving

Patricia Gorak-Stolinska; Rosemary E. Weir; Sian Floyd; Maeve K. Lalor; Sally Stenson; Keith Branson; Rose Blitz; Sarah Luke; Bernadette Nazareth; Anne Ben-Smith; Paul E. M. Fine; Hazel M. Dockrell

2006-01-01

111

Cecil Green receives Smith Medal  

NASA Astrophysics Data System (ADS)

The Waldo E. Smith Medal, which is awarded for extraordinary service to geophysics, was presented to Cecil H. Green at the 1994 AGU Fall Meeting Honors Ceremony on December 7, 1994 in San Francisco. The award citation and Green's response are given here.“It would take a book to do justice to Cecil Green's extraordinary contributions to the geophysics and electronics industries, to the training of scientists, physicians, and engineers, and to strengthening education and research institutions. In fact, such a book has been written about Cecil's multiple lives as engineer, geophysicist, cofounder of Texas Instruments, and partner with his wife, Ida, in international philanthropy.

Press, Frank; Green, Cecil

112

Immunogenicity and safety of an adjuvanted hepatitis B vaccine in pre-hemodialysis and hemodialysis patients  

Microsoft Academic Search

Immunogenicity and safety of an adjuvanted hepatitis B vaccine in pre-hemodialysis and hemodialysis patients.BackgroundDue to their impaired immune system, patients with renal insufficiency have a suboptimal response to hepatitis B (HB) vaccination and frequent boosters are needed to maintain protection. GlaxoSmithKline Biologicals has developed a HB vaccine containing a new adjuvant system AS04 for use in this immunocompromised patient population.MethodsIn

NORELLA KONG CHIEW TONG; JIRI BERAN; SWEE ANN KEE; JOSE LUIS MIGUEL; CARMEN SÁNCHEZ; JOSE MARIA BAYAS; A VILELLA; J R DE JUANES; P ARRAZOLA; FRANCISCO CALBO-TORRECILLAS; EDUARDO LÓPEZ DE NOVALES; VIRGINIE HAMTIAUX; MARC LIEVENS; MICHEL STOFFEL

2005-01-01

113

Synthesis of PDE IVb Inhibitors. 3. Synthesis of (+)-, (-)-, and (±)-7-[3-(cyclopentyloxy)-4-methoxyphenyl]hexahydro-3H-pyrrolizin-3-one via reductive domino transformations of 3-?-carbomethoxyethyl-substituted six-membered cyclic nitronates.  

PubMed

Simple three-step asymmetric and racemic syntheses of GlaxoSmithKline's highly potent PDE IVb inhibitor 1 were developed. The suggested approach is based on reductive domino transformations of 3-?-carbomethoxyethyl-substituted six-membered cyclic nitronates, which are easily accessed by a stereoselective [4 + 2] cycloaddition of an appropriate nitroalkene to vinyl ethers. In vitro studies of PDE IVb inhibition by enantiomeric pyrrolizidinones (+)-1 and (-)-1 were performed. PMID:22670642

Sukhorukov, Alexey Yu; Boyko, Yaroslav D; Nelyubina, Yulia V; Gerard, Stephane; Ioffe, Sema L; Tartakovsky, Vladimir A; Laurette Malleret, Laurette; Belaaouaj, Azzaq

2012-06-06

114

Globe-trotting medicine chests: tracing geographies of collecting and pharmaceuticals  

Microsoft Academic Search

Drawing on methodologies and theories used to understand forms of material culture, this paper traces the spatio-temporal lives of a group of medicine chests manufactured by Burroughs Wellcome and Co., the business co-founded by Henry Wellcome which is now known as GlaxoSmithKline. The paper examines the biographical, historical and commercial histories connected with these objects. In particular, it considers how

Jude Hill

2006-01-01

115

Dabrafenib: first global approval.  

PubMed

Dabrafenib (Tafinlar®), a mutant-BRAF kinase inhibitor, emerged from GlaxoSmithKline's research programme for the discovery of selective inhibitors of mutant BRAF kinase activity, for the treatment of solid tumours; mutations in the BRAF gene are associated with increased growth and proliferation of cancer cells. GlaxoSmithKline has focused the development of dabrafenib on the treatment of malignant melanoma, as BRAF mutations are present in 50 % of these cancers. Dabrafenib is approved in the US as a single agent treatment for unresectable or metastatic melanoma in patients with the BRAF V600E mutation, and has received a positive opinion in the EU in this indication. Submissions have also been made in the US and the EU for the use of dabrafenib in combination with trametinib for the treatment of metastatic melanoma with a BRAF V600E/K mutation. Global phase III development of dabrafenib as a monotherapy and as a combination therapy is ongoing in the treatment of malignant melanoma. Phase II development is ongoing for the treatment of malignant melanoma that has metastasised to the brain, and for colorectal and non-small cell lung cancers. Dabrafenib is intended to treat the patient population with a BRAF V600E/K mutation. GlaxoSmithKline's dabrafenib application in the US included the treatment of this population as detected by a US FDA-approved test. GlaxoSmithKline, in collaboration with bioMérieux and Response Genetics, has developed a molecular theranostic test to identify BRAF V600E/K mutations. Pre-Market approval of the test has been granted by the FDA. This article summarises the milestones in the development of dabrafenib leading to this first approval as a single agent treatment for unresectable or metastatic melanoma in patients with the BRAF V600E mutation. PMID:23881668

Ballantyne, Anita D; Garnock-Jones, Karly P

2013-08-01

116

An open-label, randomized, multi-center study of the immunogenicity and safety of DTaP–IPV ( Kinrix™) co-administered with MMR vaccine with or without varicella vaccine in healthy pre-school age children  

Microsoft Academic Search

BackgroundIn the US, it is recommended that 4–6 year old children receive diphtheria–tetanus–acellular pertussis (DTaP), inactivated poliovirus (IPV), measles–mumps–rubella (MMR), varicella (V), and influenza vaccines. Data relating to the concomitant administration of combination DTaP–IPV vaccine (Kinrix™; GlaxoSmithKline Biologicals) and influenza or V vaccines are currently limited. This study was undertaken to evaluate the immunogenicity and reactogenicity of Kinrix™ when co-administered

Nicola P. Klein; Wayde M. Weston; Sherine Kuriyakose; Devayani Kolhe; Barbara Howe; Leonard R. Friedland; Olivier Van Der Meeren

117

Safety, immunogenicity and immediate pain of intramuscular versus subcutaneous administration of a measles–mumps–rubella–varicella vaccine to children aged 11–21 months  

Microsoft Academic Search

This study compared intramuscular and subcutaneous administration of two doses of measles–mumps–rubella–varicella (MMRV) combination\\u000a vaccine (Priorix-Tetra™, GlaxoSmithKline Biologicals) in children. Healthy children (N?=?328) were randomised to receive MMRV either intramuscularly or subcutaneously. Reactogenicity was similar between treatment\\u000a groups for immediate vaccination pain, vaccination site pain, redness and incidence of fever and rashes. Slightly less vaccination\\u000a site swelling occurred during days

Markus Knuf; Fred Zepp; Claudius U. Meyer; Pirmin Habermehl; Lothar Maurer; Hanns-Michael Burow; Ulrich Behre; Michel Janssens; Paul Willems; Helmtrud Bisanz; Volker Vetter; Ruprecht Schmidt-Ott

2010-01-01

118

A combined measles, mumps, rubella and varicella vaccine ( Priorix-Tetra™): Immunogenicity and safety profile  

Microsoft Academic Search

Priorix-Tetra™ (GlaxoSmithKline Biologicals) is a combined measles, mumps, rubella and varicella (MMRV) vaccine. Eight studies involving more than 3000 children were reviewed. Compared with co-administration of MMR (Priorix™) and varicella (Varilrix™) vaccines, the MMRV vaccine showed: similar immunogenicity, with immunity shown up to 3 years post-vaccination; a higher rate of fever after the first dose; a slight increase in mild

Hanna Czajka; Volker Schuster; Fred Zepp; Susanna Esposito; Martine Douha; Paul Willems

2009-01-01

119

An update of prophylactic human papillomavirus L1 virus-like particle vaccine clinical trial results  

Microsoft Academic Search

This review focuses on recent publications of clinical trials of two prophylactic human papillomavirus (HPV) vaccines: Gardasil® (Merck & Co., Inc., Whitehouse Station, NJ USA), a quadrivalent vaccine containing L1 virus-like particles (VLPs) of types -6, 11, 16, and 18, and Cervarix™ (GlaxoSmithKline Biologicals, Rixensart, Belgium), a bivalent vaccine containing VLPs of types -16 and 18. In efficacy trials involving

John T. Schiller; Xavier Castellsagué; Luisa L. Villa; Allan Hildesheim

2008-01-01

120

Pandemics, antiviral stockpiles and biosecurity in Australia: what about the generic option?  

Microsoft Academic Search

In view of the possibility of a human pandemic of avian influenza, a first-line strategy for many countries is stockpiling of antiviral neuraminidase inhibitors (oseltamivir (Tamiflu) and zanamivir (Relenza)), which can reduce mortality, morbidity and influenza transmission. • However, global supply of the antivirals is controlled by the European-based patent owners, Roche and GlaxoSmithKline. This prevents competition in the manufacturing

Buddhima Lokuge; Peter Drahos; Warwick Neville

2006-01-01

121

Seroxat and the suppression of clinical trial data: regulatory failure and the uses of legal ambiguity  

Microsoft Academic Search

This article critically evaluates the Medicines and Healthcare products Regulatory Agency’s announcement, in March 2008, that GlaxoSmithKline would not face prosecution for deliberately withholding trial data, which revealed not only that Seroxat was ineffective at treating childhood depression but also that it increased the risk of suicidal behaviour in this patient group. The decision not to prosecute followed a four

L McGoey; E Jackson

2009-01-01

122

Drug advertisements: A prescription for misleading and deceptive conduct?  

Microsoft Academic Search

The Federal Court recently considered the application of a s 52 of the Trade Practices Act 1974 (Cth) (the Act) to the sophisticated marketing practices of pharmaceutical companies extolling the virtues of complex products to a specialised audience. In AstraZeneca Pty Ltd v GlaxoSmithKline Australia Pty Ltd [2005] FCA 1645, the court was required to consider whether suggesting to doctors

Damien Millen

2006-01-01

123

Genetics Home Reference: Smith-Lemli-Opitz syndrome  

MedlinePLUS

... PubMed Recent literature OMIM Genetic disorder catalog Conditions > Smith-Lemli-Opitz syndrome On this page: Description Genetic ... names Glossary definitions Reviewed July 2007 What is Smith-Lemli-Opitz syndrome? Smith-Lemli-Opitz syndrome is ...

124

Summer Circulation Patterns, Northern Smith Sound  

Microsoft Academic Search

The Naval Ocean Research and Development Activity conducted an oceanographic research program in northern Smith Sound during middle July 1977 using USCGC WESTWIND (W-AGB 281) as the data collection platform. One aspect of the program was to investigate the water mass interactions at the narrowest portion of Smith Sound which: (1) represents the boundary between this sound and Kane Basin

SAMUEL G. TOOMA

125

Applied Research Staff: Ashley Wilder Smith  

Cancer.gov

Ashley Wilder Smith, PhD, MPH, is a Behavioral Scientist in the Outcomes Research Branch of the Applied Research Program. Dr. Smith's research is focused on energy balance, health behaviors, and quality of life associated with cancer risk, progression, and survival.

126

Environmental assessment: Deaf Smith County site, Texas  

SciTech Connect

In February 1983, the US Department of Energy (DOE) identified a location in Deaf Smith County, Texas, as one of nine potentially acceptable sites for a mined geologic repository for spent nuclear fuel and high-level radioactive waste. To determine their suitability, the Deaf Smith County site and the eight other potentially sites have been evaluated in accordance with the DOE's General Guidelines for the Recommendation of Sites for the Nuclear Waste Repositories. The Deaf Smith County site is in the Permian Basin, which is one of five distinct geohydrologic settings considered for the first repository. On the basis of the evaluations reported in this EA, the DOE has found that the Deaf Smith County site is not disqualified under the guidelines. On the basis of these findings, the DOE is nominating the Deaf Smith County site as one of the five sites suitable for characterization. 591 refs., 147 figs., 173 tabs.

Not Available

1986-05-01

127

Environmental assessment, Deaf Smith County site, Texas  

SciTech Connect

The Nuclear Waste Policy Act of 1982 (42 USC sections 10101-10226) requires the environmental assessment of a proposed site to include a statement of the basis for nominating a site as suitable for characterization. Volume 2 provides a detailed statement evaluating the site suitability of the Deaf Smith County Site under DOE siting guidelines, as well as a comparison of the Deaf Smith County Site to the other sites under consideration. The evaluation of the Deaf Smith County Site is based on the impacts associated with the reference repository design, but the evaluation will not change if based on the Mission Plan repository concept. The second part of this document compares the Deaf Smith County Site to Davis Canyon, Hanford, Richton Dome and Yucca Mountain. This comparison is required under DOE guidelines and is not intended to directly support subsequent recommendation of three sites for characterization as candidate sites. 259 refs., 29 figs., 66 refs. (MHB)

Not Available

1986-05-01

128

Environmental assessment: Deaf Smith County site, Texas  

SciTech Connect

In February 1983, the US Department of Energy (DOE) identified a location in Deaf Smith County, Texas, as one of the nine potentially acceptable sites for mined geologic repository for spent nuclear fuel and high-level radioactive waste. To determine their suitability, the Deaf Smith County site and eight other potentially acceptable sites have been evaluated in accordance with the DOE's General Guidelines for the Recommendation of Sites for the Nuclear Waste Repositories. The Deaf Smith County site is in the Permian Basin, which is one of five distinct geohydrologic settings considered for the first repository. On the basis of the evaluations reported in this EA, the DOE has found that the Deaf Smith County site is not disqualified under the guidelines.

Not Available

1986-05-01

129

The Iron K?-LINE as a Tool for a Rotating Black Hole Geometry Analysis  

NASA Astrophysics Data System (ADS)

Observations of Seyfert galaxies in X-ray region reveal the broad emission lines in their spectra, which can arise in inner parts of accretion disks, where the effects of General Relativity in the strong field limit must be taken into account. A spectrum of a solitary emission line (the K?-line of iron, for example) of a hot spot in Kerr accretion disk is simulated, depending on the radial coordinate r and the angular momentum a = J/M of a black hole, under the assumption of an equatorial circular motion of a hot spot. Using results of numerical simulations it is shown that the characteristic two-peak line profile with the sharp edges arises at a large distance, if radii of emitting rings r ~ (3 - 10)rg. The inner regions emit the line, which is observed with one maximum and extremely broad red wing. We analyzed the different parameters of problems on the observable shape of this line and discussed some possible kinds of these shapes.

Zakharov, A. F.; Repin, S. V.

2003-02-01

130

Smith-Lemli-Opitz Syndrome  

PubMed Central

Smith-Lemli-Opitz syndrome (SLOS) is a multiple congenital malformation/intellectual disability syndrome, with clinical characteristics encompassing a wide spectrum and great variability. Elucidation of the biochemical and molecular genetic basis for the autosomal recessively inherited SLOS, specifically, understanding SLOS as a cholesterol deficiency syndrome caused by mutations in DHCR7, opened up enormous possibilities for therapeutic intervention. When cholesterol was discovered to be the activator of sonic hedgehog, cholesterol deficiency with inactivation of this developmental patterning gene was thought to be the cause of SLOS malformations, yet this explanation is overly simplistic. Still, despite these important research breakthroughs, there is no proven treatment for SLOS. Better animal models are needed to allow potential treatment testing and the study of disease pathophysiology, which is incompletely understood. Creation of human cellular models will surely be useful, especially models of brain cells. In vivo human studies are essential as well. There have only been limited natural history studies of SLOS to date. Biomarker development will be critical in facilitating clinical trials in this rare condition, since clinical phenotype may change over many years. Additional research in these and other areas is critical if we are to make headway towards ameloriating the effects of this devastating condition.

DeBarber, Andrea E.; Eroglu, Yasemen; Merkens, Louise S.; Pappu, Anuradha S.; Steiner, Robert D.

2012-01-01

131

SMITH FARM FROM EBEY ROAD, LOOKING NORTH. (At the right, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

SMITH FARM FROM EBEY ROAD, LOOKING NORTH. (At the right, this image shows the addition added to the granary in 1998 in order to adapt it to a family home.) - Smith Farm, 399 Ebey Road, Coupeville, Island County, WA

132

SMITH FARM FROM COOK ROAD, LOOKING WEST. (The farm buildings ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

SMITH FARM FROM COOK ROAD, LOOKING WEST. (The farm buildings from left to right are: granary, garage, Gould house, and barn. The Olympic Mountains are visible in the distance.) - Smith Farm, 399 Ebey Road, Coupeville, Island County, WA

133

February 14, 2012 CURRICULUM VITAE Robert John Smith ...  

Center for Biologics Evaluation and Research (CBER)

Text Version... 56. Helton S, Jacobs DO, Bonner-Weir S, Bueno R, Smith RJ, Wilmore DW. ... 64. Abbott AM, Bueno R, Pedrini MT, Murray JM, Smith RJ. ... More results from www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials

134

The energy behind Vernon Smith's experimental economics  

Microsoft Academic Search

This paper begins with the interplay of the induced value theory and the Hayek hypothesis, and subsequently suggests that we need to understand Vernon Smith's experimental method as not simply empirical, but encompassing a commitment to a special version of neoclassical demand theory. To this end, we compare his commitment to Harold Hotelling's important work on demand, an exemplar of

Kyu Sang Lee; Philip Mirowski

2008-01-01

135

Is the Cerebellum a Smith Predictor?  

Microsoft Academic Search

The motor system may use internal predictive models of the motor apparatus to achieve better control than would be possible by negative feedback. Several theories have proposed that the cerebellum may form these predictive representations. In this article, we review these theories and try to unify them by reference to an engineering control model known as a Smith Predictor. We

R. C. Miall; D. J. Weir; D. M. Wolpert; J. F. Stein

1993-01-01

136

Applied Research Staff: Susan Krebs-Smith  

Cancer.gov

Susan Krebs-Smith, PhD, is the Chief of the Risk Factor Monitoring and Methods Branch of the Applied Research Program. In that capacity, she oversees a program of research on the surveillance of risk factors related to cancer, methodological issues to improve the assessment of those factors, and issues related to guidance and food policy.

137

Adam Smith, Stoicism and religion in the 18th century  

Microsoft Academic Search

This article explores the influence of Stoicism and religion on Adam Smith. While other commentators have argued either that the main influence on Smith was Stoicism or that it was religion, the two influences have not been explicitly linked. In this article I attempt to make such a link, arguing that Smith can be seen as belonging to the strand

P. H. Clarke

2000-01-01

138

Julian Smith: scientific surgeon, photographer, inventor.  

PubMed

Julian Augustus Romaine Smith was one of the surgeons who, in the company of Thomas Dunhill, Hugh Devine, Douglas Shields and David Murray Morton, established Saint Vincent's Hospital, Melbourne, as arguably the premier surgical hospital in Victoria, if not Australia. Smith abandoned a most promising scientific career to study medicine, completing his medical course in Melbourne where he graduated top of his year in 1898/1899. He gained his MD in 1901 and set up practice in Morwell, a Victorian country town, where he initiated his surgical career. In 1905 Smith returned to Melbourne and worked as assistant to Mr F. D. Bird, a prominent surgeon. He travelled overseas in 1906, visiting leading medical centres in England where Almroth Wright's work on vaccination made a deep impression on him. On his return to Australia in 1908 he joined the surgical staff at Saint Vincent's Hospital as surgeon to outpatients, finally retiring as surgeon to inpatients in 1928. Smith was made a Foundation Fellow of the Australasian College of Surgeons in 1927. Smith was regarded by his peers as a brilliant innovative surgeon with a special interest in urology. He became an expert cystoscopist. After he retired, he continued his long-standing interest in portrait photography for which he was considered a master. During World War II he designed and built an elegant roller pump for use in direct blood transfusion. He died in 1947, survived by his wife, a daughter and three sons, one of whom became President of the Royal Australasian College of Surgeons. PMID:11906425

Vellar, Ivo D

2002-01-01

139

Guide to the Smith Family Papers on World War II, 1936-2005  

Microsoft Academic Search

Papers of two generations of the Smith family — Dr. Frank Herron Smith and his son Dr. Morris Eugene “Gene” Smith — including vintage broadsides and government reports on the internment of Japanese-Americans during World War II and correspondence from the elder Smith to government officials advocating for improved treatment and safety for returning internees. Also includes Gene Smith’s personal

Denise Fourie

2007-01-01

140

Otorhinolaringologic manifestation of Smith–Magenis syndrome  

Microsoft Academic Search

Smith–Magenis syndrome (SMS) is a multiple congenital anomaly\\/mental retardation (MCA\\/MR) syndrome link to a contiguous-gene deletion syndrome, involving chromosome 1 7p 11.2,whose incidence is estimated to be 1:25?000 livebirth. SMS is characterised by a specific physical, behavioural and developmental pattern. The main clinical features consist of a broad flat midface with brachycefaly, broad nasal bridge, brachydactily, speech delay, hoarse deep

M Di Cicco; R Padoan; G Felisati; D Dilani; E Moretti; S Guerneri; A Selicorni

2001-01-01

141

Differential Posets and Smith Normal Forms  

Microsoft Academic Search

We conjecture a strong property for the up and down maps U and D in an r-differential poset: DU + tI and UD + tI have Smith normal forms over Z(t). In particular, this would determine the integral structure of the maps U, D, UD, DU, including their ranks in any characteristic. As evidence, we prove the conjecture for the

Alexander Miller; Victor Reiner

2009-01-01

142

Turbulent Fluctuations in G-band and K-line Intensities Observed with the Rapid Oscillations in the Solar Atmosphere (ROSA) Instrument  

NASA Astrophysics Data System (ADS)

Using the Rapid Oscillation in the Solar Atmosphere (ROSA) instrument at the Dunn Solar Telescope we have found that the spectra of fluctuations of the G-band (cadence 1.05 s) and Ca II K-line (cadence 4.2 s) intensities show correlated fluctuations above white noise out to frequencies beyond 300 mHz and up to 70 mHz, respectively. The noise-corrected G-band spectrum presents a scaling range (Ultra High Frequency “UHF”) for f = 25-100 mHz, with an exponent consistent with the presence of turbulent motions. The UHF power, is concentrated at the locations of magnetic bright points in the intergranular lanes, it is highly intermittent in time and characterized by a positive kurtosis ?. Combining values of G-band and K-line intensities, the UHF power, and ?, reveals two distinct “states” of the internetwork solar atmosphere. State 1, with ? ? 6, which includes almost all the data, is characterized by low intensities and low UHF power. State 2, with ? ? 3, including a very small fraction of the data, is characterized by high intensities and high UHF power. Superposed epoch analysis shows that for State 1, the K-line intensity presents 3.5 min chromospheric oscillations with maxima occurring 21 s after G-band intensity maxima implying a 150-210 km effective height difference. For State 2, the G-band and K-line intensity maxima are simultaneous, suggesting that in the highly magnetized environment sites of G-band and K-line emission may be spatially close together. Analysis of observations obtained with Hinode/SOT confirm a scaling range in the G-band spectrum up to 53 mHz also consistent with turbulent motions as well as the identification of two distinct states in terms of the H-line intensity and G-band power as functions of G-band intensity.

Cadavid, A. C.; Lawrence, J. K.; Christian, D. J.; Jess, D. B.; Mathioudakis, M.

2012-12-01

143

Near-coincident K-line and K-edge energies as ionization diagnostics for some high atomic number plasmas  

NASA Astrophysics Data System (ADS)

For some high atomic number atoms, the energy of the K-edge is tens of eVs higher than the K-line energy of another atom, so that a few eV increase in the line's energy results in a decreasing transmission of the x-ray through a filter of the matching material. The transmission of cold iridium's ~=63.287 keV K?2 line through a lutetium filter is 7% lower when emitted by ionized iridium, consistent with an energy increase of ??~=10+/-1 eV associated with the ionization. Likewise, the transmission of the K?1 line of ytterbium through a near-coincident K-edge filter changes depending on plasma parameters that should affect the ionization. Systematic exploration of filter-line pairs like these could become a unique tool for diagnostics of suitable high energy density plasmas.

Pereira, N. R.; Weber, B. V.; Phipps, D. G.; Schumer, J. W.; Seely, J. F.; Carroll, J. J.; Vanhoy, J. R.; S?abkowska, K.; Polasik, M.

2012-10-01

144

60% Review technical specifications, Deaf Smith Site  

SciTech Connect

The enclosed documentation for the 60% Review Technical Specifications, Deaf Smith Site includes: Solicitation Documents which represent the eventual Federal Acquisition Regulations (FARs) and Department of Energy Acquisition Regulations (DEARs) that will comprise a segment of the contractual documents for bidders attention; Contract Clauses that will become integral parts for the Fixed Price Construction Contracts applicable to the Exploratory Shaft Facility; Special Contract Requirements that will become contract provisions requiring specific contractor attention; Technical Specifications which have been completed for 60% submission, and the current list of 241 Contract Drawings that have been separately forwarded for review and comment.

Gast, R.A.

1987-08-01

145

Experimental investigations of Smith--Purcell radiation  

SciTech Connect

We present experimental investigations of Smith--Purcell radiation and Salisbury's model and emphasize the amplification mechanism and efforts to build a resonator operating in the visible wavelength region. The first experiment demonstrated that electrons can be reflected from a rough surface owing to crystal-lattice diffraction. The second experiment showed that the radiation output increases exponentially as the beam thickness increases, indicating a possible occurrence of lasing action; the results were consistent with Salisbury's model. The last experiment yielded inconclusive results; the use of a more stable electron beam and a blazed grating is suggested for future experiments.

Shih, I.; Chang, D.; Drummond, J.; Dubbs, K.; Masters, D.; Prohaska, R.; Salisbury, W. (Hughes Aircraft Company, Support Systems, P.O. Box 9399, Long Beach, California 90810-0399 (US))

1990-03-01

146

Measurements of Smith--Purcell radiation  

SciTech Connect

We present experimental results on Smith--Purcell radiation. Our primary interest was in the measurement of radiation angular distribution, output power, and spectral content. The variations of the angular distribution and the output power were shown for different electron-beam voltages and currents. The output power measured with a 3-mA and 120-kV electron beam was {similar to}30 {mu}W/cm{sup 2}-sr. The spectral analysis of the radiation shows excellent agreement between the measurements and the theoretical predictions. Our results were compared with those obtained by Gover et al. (J. Opt. Soc. Am. B 1, 723 (1984)).

Shih, I.; Salisbury, W.; Masters, D.; Chang, D. (Hughes Aircraft Company, Support Systems, P.O. Box 9399, Long Beach, California 90810-0399 (US))

1990-03-01

147

IONIZED GAS IN THE SMITH CLOUD  

SciTech Connect

We present Wisconsin Halpha Mapper observations of ionized gas in the Smith Cloud, a high-velocity cloud which Lockman et al. have recently suggested is interacting with the Galactic disk. Our Halpha map shows the brightest Halpha emission, 0.43 +- 0.04 R, coincident with the brightest H I, while slightly fainter Halpha emission (0.25 +- 0.02 R) is observed in a region with H I intensities <0.1 times as bright as the brightest H I. We derive an ionized mass of approx>3 x 10{sup 6} M {sub sun}, comparable to the H I mass, with the H{sup +} mass spread over a considerably larger area than that of H I. An estimated Galactic extinction correction could adjust these values upward by 40%. Halpha and [S II] line widths toward the region of brightest emission constrain the electron temperature of the gas to be between 8000 K and 23,000 K. A detection of [N II] lambda6583 in the same direction with a line ratio [N II]/Halpha = 0.32 +- 0.05 constrains the metallicity of the cloud: for typical photoionization temperatures of 8000-12,000 K, the nitrogen abundance is 0.15-0.44 times solar. These results lend further support to the claim that the Smith Cloud is new material accreting onto the Galaxy.

Hill, Alex S.; Haffner, L. Matthew; Reynolds, Ronald J., E-mail: hill@astro.wisc.ed, E-mail: haffner@astro.wisc.ed, E-mail: reynolds@astro.wisc.ed [Department of Astronomy, University of Wisconsin-Madison, Madison, WI 53706 (United States)

2009-10-01

148

George W. Smith, M.D. (1916-1964).  

PubMed

Dr. George W. Smith is credited with developing the Smith-Robinson procedure, the automatic drill, the vessel-encircling aneurysm clip, and treatment of tic douloureux with stilbamidine. His contributions to neurosurgery were unfortunately truncated by his untimely death. This article highlights his career and his contributions. PMID:22900843

Viers, Angela; Allen, Marshall B; Alleyne, Cargill H

2012-08-17

149

Author! Author! The Gallant Children's Author: Dick King-Smith  

ERIC Educational Resources Information Center

|This column presents a brief biography of Dick King-Smith. Born on March 27, 1922 and raised in Gloucestershire, England, he grew up with animals of all kinds. King-Smith was a farmer for twenty years and then became a school teacher. He was also a soldier during wartime, a traveling salesman, shoe factory worker, and television presenter. He…

Brodie, Carolyn S.

2005-01-01

150

Oscar F. Smith Middle School: One Extra Degree  

ERIC Educational Resources Information Center

|This article features Oscar F. Smith Middle School, a challenging school in Chesapeake, Virginia. When Principal Linda Scott exclaims, "Oscar F. Smith Middle School is "hot"!" to visitors, she is not referring to the inside temperature of the bustling school of grades 6-8 located in the historic South Norfolk borough of Chesapeake. She is…

Principal Leadership, 2012

2012-01-01

151

The continuing careers of Smith, Jones, and Brown  

Microsoft Academic Search

In the pages of Between Forums we have been following the academic careers of three faculty members who began their careers at the same college in the late 1950s. As composites of faculty members in American higher education, Smith, Jones, and Brown reflect the opportunities and adversities that give academic careers a particular fascination. The following encounter with Smith, Jones,

Cameron Fincher

1985-01-01

152

Last Interview with W. Eugene Smith on the Photo Essay.  

ERIC Educational Resources Information Center

An interview with W. Eugene Smith, well-known photographer and photographic essayist, is presented in this paper. The introductory section of the paper contains a biographical sketch of Smith and a discussion of his photographic essays on a number of topics, including World War II scenes, life in a Spanish village, the work of a black midwife in…

Kobre, Ken

153

Brown's syndrome associated with Smith-Magenis syndrome: Case report.  

PubMed

Brown's syndrome is generally an isolated clinical condition. The authors observed a girl with a right Brown's syndrome and a rare condition due to an interstitial deletion of chromosome 17, known as Smith-Magenis syndrome. A wide spectrum of congenital disorders have been reported in Smith-Magenis syndrome, but never Brown's syndrome. PMID:21314509

Salati, R; Marini, G; Degiuli, A; Dalprà, L

1996-01-01

154

Environmental assessment overview, Deaf Smith County site, Texas  

SciTech Connect

In February 1983, the US Department of Energy (DOE) identified a location in Deaf Smith County, Texas, as one of nine potentially acceptable sites for mined geologic repository for spent nuclear fuel and high-level radioactive waste. To determine their suitability, the Deaf Smith County site and eight other potentially acceptable sites have been evaluated in accordance with the DOE's General Guidelines for the Recommendation of Sites for the Nuclear Waste Repositories. The Deaf Smith County site is in the Permian Basin, which is one of five distinct geohydrologic settings considered for the first repository. On the basis of the evaluations reported in this EA, the DOE has found that the Deaf Smith County site is not disqualified under the guidelines. On the basis of these findings, the DOE is nominating the Deaf Smith County site as one of five sites suitable for characterization. 3 figs.

Not Available

1986-05-01

155

Safety and Immunogenicity of Early Vaccination with Two Doses of Tetravalent Measles-Mumps-Rubella-Varicella (MMRV) Vaccine in Healthy Children from 9 Months of Age  

Microsoft Academic Search

Background:  This open, randomized, controlled study [208136\\/018] assessed the safety and immunogenicity of early vaccination with an experimental\\u000a tetravalent measlesmumps-rubella-varicella (MMRV) vaccine (GlaxoSmithKline Biologicals) compared to concomitant administration\\u000a of separate licensed MMR (Priorix™) and varicella (Varilrix™) vaccines (MMR+V).\\u000a \\u000a \\u000a \\u000a Methods:  Vaccines were administered as a two-dose course in healthy children at 9 and 12 months of age (N = 153 in the MMRV

P. Goh; F. S. Lim; H. H. Han; P. Willems

2007-01-01

156

Immunogenicity and safety of a tetravalent measles-mumps-rubella-varicella vaccine co-administered with a booster dose of a combined diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus Haemophilus influenzae type b conjugate vaccine in healthy children aged 12–23 months  

Microsoft Academic Search

This study was undertaken to assess the co-administration of an experimental measles-mumps-rubella-varicella vaccine (MMRV,\\u000a GlaxoSmithKline Biologicals) with a combined diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus-Haemophilus influenzae type b conjugate (DTPa-HBV-IPV\\/Hib) vaccine in healthy children. Healthy children aged 12–23 months (N?=?451) were randomised to one of three parallel groups to receive one dose of MMRV vaccine co-administered with a booster\\u000a dose of DTPa-HBV-IPV\\/Hib vaccine

Fred Zepp; Ulrich Behre; Klaus Kindler; Karl-Heinz Laakmann; Heidemarie Pankow-Culot; Wilma Mannhardt-Laakmann; François Beckers; Dominique Descamps; Paul Willems

2007-01-01

157

Mepolizumab in eosinophilic disorders  

PubMed Central

Mepolizumab (Bosatria®, GlaxoSmithKline) is a biologic agent developed to treat asthma. It represents a humanized monoclonal antibody of IgG1 ? type, which targets human IL-5 and thus prevents its interaction with the ?-chain of the IL-5 receptor. To date, it has not been approved for use in any eosinophil-related disorder; however, several studies have suggested some therapeutic benefit across a spectrum of eosinophil-related disorders. This article evaluates the currently available preclinical and clinical studies, and the impact of mepolizumab against a variety of eosinophilic disorders.

Abonia, J Pablo; Putnam, Philip E

2011-01-01

158

Synthesis of PDE IVb inhibitors. 1. Asymmetric synthesis and stereochemical assignment of (+)- and (-)-7-[3-(cyclopentyloxy)-4-methoxyphenyl]hexahydro-3H-pyrrolizin-3-one.  

PubMed

Asymmetric synthesis of GlaxoSmithKline's highly potent phosphodiesterase inhibitor 1 has been accomplished in nine steps and 16% overall yield. The original strategy suggested involves as a key step the silylation of enantiopure six-membered cyclic nitronates 4 obtained by a highly stereoselective [4 + 2]-cycloaddition of an appropriate nitroalkene 5 to trans-1-phenyl-2-(vinyloxy)cyclohexane. Functionalization of the resulting 5,6-dihydro-4H-1,2-oxazine and subsequent stereoselective reduction of 1,2-oxazine ring in intermediate 2 furnished the pyrrolizidinone framework with the recovery of chiral auxiliary alcohol. PMID:21866916

Sukhorukov, Alexey Yu; Boyko, Yaroslav D; Ioffe, Sema L; Khomutova, Yulia A; Nelyubina, Yulia V; Tartakovsky, Vladimir A

2011-09-16

159

32nd National Medicinal Chemistry Symposium--medicinal chemistry developments for neurodegeneration, diabetes and cancer.  

PubMed

The 32nd National Medicinal Chemistry Symposium, held in Minneapolis, MN, USA, included topics covering new developments in the field of medicinal chemistry. This conference report highlights selected presentations on NR2B subtype-selective NMDA receptor antagonists from Merck; selective neuronal nitric oxide synthase inhibitors from Northwestern University; novel GPR119 agonists, suchas GSK-1292263A (GlaxoSmithKline plc), PSN-821 ((OSI) Prosidion) and MBX-2982 (Metabolex Inc); a small-molecule Bcl inhibitor,navitoclax (Abbott Laboratories); and p53-targeting agents from sanofi-aventis and Ascenta Therapeutics Inc, including AT-219. PMID:20721817

Gater, Deborah

2010-08-01

160

International team finds a bioactive protein from ancient medicinal plant may help combat melanoma and other cancers  

Cancer.gov

An international team led by scientists from the University of Medicine and Dentistry of New Jersey-School of Osteopathic Medicine, has found that a protein from the seeds of a plant used for centuries in traditional medicines may be able to halt the spread of melanoma, a lethal form of skin cancer. The study included collaborators from Nagoya University, the University of Michigan and GlaxoSmithKline. The University of Medicine and Dentistry of New Jersey is an academic affiliate of the Cancer Institute of New Jersey.

161

Immunogenicity and safety of a low-dose diphtheria, tetanus and acellular pertussis combination vaccine with either inactivated or oral polio vaccine as a pre-school booster in UK children  

Microsoft Academic Search

This open, randomised controlled trial studied the immunogenicity and reactogenicity of two combined low-dose diphtheria, tetanus and acellular pertussis vaccines (Td5aP-IPV, REPEVAX™, Aventis Pasteur MSD; and Td5aP, COVAXIS™, Aventis Pasteur MSD + OPV, GlaxoSmithKline) in comparison with a standard dose diphtheria pre-school booster vaccine (DT2aP-IPV, TETRAVAC™, Aventis Pasteur MSD) in a population of 3.5–5-year-old children administered concomitantly with measles, mumps

C. L. Collins; P. Salt; N. McCarthy; T. Chantler; F. Hemme; L. Diggle; J. Buttery; N. R. E. Kitchin; E. R. Moxon; A. J. Pollard

2004-01-01

162

Retapamulin for impetigo and other infections.  

PubMed

Last year, we concluded that topical fusidic acid should be first-line treatment for impetigo. Since then, retapamulin ointment (Altargo - GlaxoSmithKline), a new antibacterial, has been licensed in the European Union as a short-term treatment for impetigo and infected small lacerations, abrasions or sutured wounds in people aged 9 months or above. Advertisements claim that the product "treats localised impetigo in just 5 days"; by comparison, the British National Formulary (BNF) advises a 7-day course of fusidic acid. Here we consider the place of retapamulin in impetigo and its other licensed indications. PMID:18832258

2008-10-01

163

The Making of I-BET762, a BET Bromodomain Inhibitor Now in Clinical Development.  

PubMed

Bromodomain and extra-terminal (BET) proteins belong to a class of proteins collectively called epigenetic "readers". BET bromodomains have emerged as promising drug targets for treatment of cancers, inflammatory diseases, and other medical conditions. GlaxoSmithKline scientists have successfully optimized a class of benzodiazepines as inhibitors of BET bromodomains, without any prior knowledge of identified molecular targets. It thus is possible to hit a target without aiming at it. The optimized lead compound I-BET762 is currently being evaluated in a phase I clinical trial for treatment of human cancer. PMID:24107192

Zhao, Yujun; Yang, Chao-Yie; Wang, Shaomeng

2013-09-25

164

The rise of China: Marx's solution or Adam Smith's? On China's rise in Adam Smith in Beijing by Giovanni Arrighi  

Microsoft Academic Search

Adam Smith in Beijing offers a subversive analysis of China's rise, an analysis which has provoked a strong reaction in the academic world outside China. Based on Adam Smith's economic principles and world systems analysis, the book comprehensively explores China's reform and opening up and its market economy, as well as the role they have played in China's rise. In

Wu Yuanhua

2011-01-01

165

Otorhinolaringologic manifestation of Smith-Magenis syndrome.  

PubMed

Smith-Magenis syndrome (SMS) is a multiple congenital anomaly/mental retardation (MCA/MR) syndrome link to a contiguous-gene deletion syndrome, involving chromosome 1 7p 11.2,whose incidence is estimated to be 1:25,000 livebirth. SMS is characterised by a specific physical, behavioural and developmental pattern. The main clinical features consist of a broad flat midface with brachycefaly, broad nasal bridge, brachydactily, speech delay, hoarse deep voice and peripheral neuropathy. Behavioural abnormalities include hypermotility, self-mutilation and sleep disturbance. This report defines the otorhinolaryngological aspects of a new case of SMS, confirmed by cytogenetic-molecular analysis, in a 9 year old girl affected by chronic otitis media, deafness and sinusitis, who presented with typical clinical signs and symptoms. PMID:11378192

Di Cicco, M; Padoan, R; Felisati, G; Dilani, D; Moretti, E; Guerneri, S; Selicorni, A

2001-06-01

166

Coherent Transition and Smith Purcell Radiation Experiments  

SciTech Connect

We review results from radiation experiments done at MIT on the Haimson Research Corporation (HRC) 17 GHz linear accelerator. Both Smith-Purcell radiation (SPR), and Coherent Transition radiation (CTR) were observed. To understand SPR, an Electric Field Integral Equation (EFIE) method was developed and confirmed with an experiment. Because our linac produces a train of bunches, radiation was only observed at integer multiples of the RF frequency. New measurements made on CTR show excellent agreement with EFIE expectations, on an absolute scale, and also provide a bunch length measurement. The possibility for an absolute scale bunch length measurement is confirmed with a proof of principle experiment. Future extension of the EFIE code and corollary experiments are discussed.

Marsh, Roark A.; Kesar, Amit S.; Temkin, Richard J. [Plasma Science and Fusion Center, Massachusetts Institute of Technology, 167 Albany Street, Cambridge, Massachusetts 02139 (United States)

2006-11-27

167

Sophia Smith Collection: Voices of Feminism  

NSDL National Science Digital Library

Based at Smith College, the Voices of Feminism Oral History Project "documents the persistence and diversity of organizing for women in the United States in the latter half of the 20th century." The women interviewed here include labor, peace, and anti-racism activists, along with anti-poverty organizers and lesbian rights advocates. The project was funded by the Ford Foundation from 2002 to 2008, and visitors will find that they can also read transcripts of the interviews as well. The "Narrators" page features biographical profiles of each interviewee, along with links to the transcript of each interview. As a bonus feature, there are video excerpts for six of the women interviewed as part of the project.

168

First observation of Smith-Purcell radiation from relativistic electrons  

NASA Astrophysics Data System (ADS)

A beam of 3.6-MeV electrons has been used to study the generation of radiation in the far infrared (FIR) by the Smith-Purcell mechanism. The dependence of wavelength on angle of emission, over angles from 56 to 150 deg and wavelengths from 350 to 1860 microns, is in excellent agreement with the Smith-Purcell dispersion relation. Comparison of the yield with that from a 5000-K source suggests that the spontaneous Smith-Purcell effect offers an easily tunable alternative to the synchrotron as a coherent FIR source, and that it could also form the basis of an inexpensive, compact free-electron laser.

Doucas, G.; Mulvey, J. H.; Omori, M.; Walsh, J.; Kimmitt, M. F.

1992-09-01

169

3. Historic American Buildings Survey, Delos H. Smith, Photographer May ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. Historic American Buildings Survey, Delos H. Smith, Photographer May 29, 1940 GENERAL LAFAYETTE DELIVERED AN ADDRESS FROM THE PORCH OF THIS HOUSE. - Pegues-McKay House, Kershaw & Third Streets, Cheraw, Chesterfield County, SC

170

Bruce Smith, Raymond Carver Reading Series, September 11, 2002  

Microsoft Academic Search

A video recording of Bruce Smith reading his poems on September 11, 2002 as part of the Syracuse University Creative Writing Program's Raymond Carver Reading Series. Mary Karr provides the introduction. Running time: 52:41

Bruce Smith

2002-01-01

171

5. Historic American Buildings Survey, Delos H. Smith, Photographer, 1940 ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. Historic American Buildings Survey, Delos H. Smith, Photographer, 1940 DIAGONAL VIEW OF PERISTYLE AROUND BASE OF TOWER. - Cathedral of St. Peter in Chains, Eighth & Plum Streets, Cincinnati, Hamilton County, OH

172

Conversations with Patricia Grace Smith. Interview by Frank Sietzen Jr.  

PubMed

Ms. Smith, associate administrator for commercial space transportation within the Federal Aviation Administration, answers questions about regulations and licensing related to reusable launch vehicles, space passenger vehicles, and commercial space ventures. PMID:14968786

Smith, Patricia Grace

2004-02-01

173

VIEW OF HOWLAND HILL ROAD, JEDEDIAH SMITH STATE PARK. CRESCENT ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

VIEW OF HOWLAND HILL ROAD, JEDEDIAH SMITH STATE PARK. CRESCENT CITY, DEL NORTE COUNTY, CALIFORNIA. LOOKING E. - Redwood National & State Parks Roads, California coast from Crescent City to Trinidad, Crescent City, Del Norte County, CA

174

8. Historic American Buildings Survey Delos H. Smith, Photographer 1936 ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

8. Historic American Buildings Survey Delos H. Smith, Photographer 1936 - Dr. David Ross House, Annapolis Road (moved to Preservation Hill, Western Run Road, Cockeysville), Bladensburg, Prince George's County, MD

175

Medical Device Notification: Hotline L-10 Gas Vent-Smiths ...  

Center for Biologics Evaluation and Research (CBER)

... Medical Device Notification: Hotline L-10 Gas Vent-Smiths Medical ASD, Inc. DATE NOTIFICATION INITIATED: August 2, 2005. ... More results from www.fda.gov/biologicsbloodvaccines/safetyavailability/recalls

176

DETAIL OF WESTINGHOUSE AND B. MORGAN SMITH NAMEPLATES ON ELECTRIC ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

DETAIL OF WESTINGHOUSE AND B. MORGAN SMITH NAMEPLATES ON ELECTRIC GENERATOR IN UPPER LEVEL OF HYDROELECTRIC POWER HOUSE - St. Lucie Canal, Lock No. 1, Hydroelectric Power House, St. Lucie, Cross State Canal, Okeechobee Intracoastal Waterway, Stuart, Martin County, FL

177

MORTALITY ESTIMATES FROM SIZE DISTRIBUTIONS: A CRITIQUE OF SMITH'S MODEL  

EPA Science Inventory

Smith (1972) described a method of computing mortality rates from growth and size-frequency data for a population which meets several assumptions. (Copyright (c) 1977 by The American Society of Limnology and Oceanography, Inc.)...

178

Smith-Purcell free-electron laser  

SciTech Connect

We analyze the operation of a free-electron laser in an open periodicstructure. When operated as an amplifier, it is shown that exponential gain candevelop in such a device. An analytic expression for this gain is presented,and it is shown that this gain decays exponentially with the beam height abovethe grating; the gain dependence on the beam thickness is also analyzed. As theenergy extraction rate is much higher in an exponential gain regime, we alsoinvestigate the operation of an oscillator based on the same concept. In thiscase, the Smith-Purcell radiation ''provides the startup'' through a feedbacksystem. The latter consists of several mirrors, which are placed in such a waythat (1) only a wave with the desired frequency develops and, at the same time,(2) small deviations in the wave parameters due to the wave-beam interaction donot cause deflection of the wave from the feedback loop. The minimal currentneeded to sustain oscillations is given in an analytical form. Numericalcalculations show that this current is more than three orders of magnitudelower than that necessary for an oscillator which operates in an algebraic gainregime.

Schachter, L.; Ron, A.

1989-07-15

179

A comparison between two hydrothermally formed extensional environment related kaolin deposits: Balikesir-Duvertepe, Turkey and Kline Mountain, Sierra County, New Mexico  

SciTech Connect

Economically important and hydrothermally formed kaolin deposits are often found within rift lithologic units, formed as a result of interaction of physical and geochemical processes in the extensional environment. The kaolin deposits of Balikesir--Duvertepe, Turkey and Kline Mountain, Sierra County, New Mexico, studied herein, are examples of this type. The Balikesir--Duvertepe district has been known as the most productive kaolin district in Turkey. Total reserves are estimated at 15 million metric tons. Located in the active Simav Graben produced by the subduction of the African Plate under the Aegean region, the kaolin deposits occur irregularly and variably in quality as a result of hydrothermal alteration of Neogene tuffs. The Kline Mountain kaolin deposit was formed as a result of advanced argillic alteration on the southeastern edge of the Mogollon--Datil volcanic field, which is related to the extensional environment of Basin and Range province and the Rio Grande rift. Its reserve is reported as 200 million metric tons of altered tuffs. The two deposits show striking similarities: extensional related rock units, intense in situ hydrothermal alteration, mineral content, seismic activity, alunite contamination, chemical composition, and intense silicification. The deposits also display some differences: regional climate, the intensity of hydrothermal alteration and the elapsed time causing relatively complete replacement in the Turkish deposit compared to that in NM. The Balikesir--Duvertepe district has been the center of kaolin marketing for use chiefly in ceramic, paper, and white cement, while the Kline Mountain kaolin had been exploited primarily for paper and ceramic tile as a coating; and in the oil industry as a filler and absorbent material.

Isik, I.; Clark, K.F. (Univ. of Texas, El Paso, TX (United States). Dept. of Geological Sciences)

1992-01-01

180

Kiki Smith: Prints, Books & Things at MoMA  

NSDL National Science Digital Library

Using a similar interface to that of Artists of Brücke (German Expressionist prints, reviewed in the December 5, 2003 and Nov.2, 2001 Scout Reports), the Museum of Modern Art (MoMA) presents this major retrospective of the work of Kiki Smith, born in 1954 in Nuremberg, Germany. Smith is the daughter of American sculptor Tony Smith, and her first experience with art was helping her father make cardboard models for his geometric sculptures. She is thought of as a sculptor and builder of installations, but since the 1980s, has created an extensive body of printed works, 135 of which are gathered in this web exhibition. Like the Expressionist show, the Smith show features a virtual light table of images that can be arranged dynamically by Themes -- early screen prints, anatomy, self-portraits, nature, feminine contexts -- or Mediums. In recent years, Smith has worked on etchings pulled from plates of monumental size, roughly 4 feet by 6 feet, such as a series based on Lewis Carroll, including Pool of Tears 2 (2000) and Come Away from Her (2003). The site also includes a chronology of Smith's life and a 35-page essay by Wendy Weitman, MoMA's Curator of Prints and illustrated Books.

181

Smith's rent gap theory and local real estate dynamics: A multi-agent model  

Microsoft Academic Search

The aim of this paper is to investigate local housing market dynamics by applying an urban spatial model of gentrification based on Smith’s rent gap theory [Smith, N. (1979). Toward a theory of gentrification: a back to the city movement by capital, not people. APA Journal, 538–548]. Smith’s supply side approach explains the emergence of gentrifying neighbourhoods on the basis

Lidia Diappi; Paola Bolchi

2008-01-01

182

Magnetized Gas in the Smith High Velocity Cloud  

NASA Astrophysics Data System (ADS)

We report the first detection of magnetic fields associated with the Smith High Velocity Cloud. We use a catalog of Faraday rotation measures toward extragalactic radio sources behind the Smith Cloud, new H I observations from the Robert C. Byrd Green Bank Telescope, and a spectroscopic map of H? from the Wisconsin H-Alpha Mapper Northern Sky Survey. There are enhancements in rotation measure (RM) of ?100 rad m–2 which are generally well correlated with decelerated H? emission. We estimate a lower limit on the line-of-sight component of the field of ?8 ?G along a decelerated filament; this is a lower limit due to our assumptions about the geometry. No RM excess is evident in sightlines dominated by H I or H? at the velocity of the Smith Cloud. The smooth H? morphology of the emission at the Smith Cloud velocity suggests photoionization by the Galactic ionizing radiation field as the dominant ionization mechanism, while the filamentary morphology and high (?1 Rayleigh) H? intensity of the lower-velocity magnetized ionized gas suggests an ionization process associated with shocks due to interaction with the Galactic interstellar medium. The presence of the magnetic field may contribute to the survival of high velocity clouds like the Smith Cloud as they move from the Galactic halo to the disk. We expect these data to provide a test for magnetohydrodynamic simulations of infalling gas.

Hill, Alex S.; Mao, S. A.; Benjamin, Robert A.; Lockman, Felix J.; McClure-Griffiths, Naomi M.

2013-11-01

183

Thermodynamic implications of the Stiller-Smith mechanism  

SciTech Connect

The Stiller-Smith mechanism is a new mechanism for the translation of linear motion into rotary motion, and has been considered as an alternative to the conventional slider-crank mechanism in the design of internal combustion engines and piston compressors. Piston motion differs between the two mechanisms, being perfectly sinusoidal for the Stiller-Smith case. Plots of dimensionless volume and volume rate change are presented for one engine cycle. It is argued that the different motion is important when considering rate-based processes such as heat transfer to a cylinder wall and chemical kinetics during combustion. This paper also addresses the fact that a Stiller-Smith engine will be easier to configure for adiabatic operation, with many attendant benefits.

Lee, K.; Clark, N.; George, A.; Petrucci, V.

1987-01-01

184

Additional corrections to the Gross-Llewellyn Smith sum rule  

NASA Astrophysics Data System (ADS)

We investigate some QCD corrections that contribute to the Gross-Llewellyn Smith sum rule but have not been included in previous analyses of it. We first review the techniques by which the xF3 structure function is extracted from combinations of neutrino and antineutrino cross sections. Next we investigate corrections to the Gross-Llewellyn Smith sum rule, with particular attention to contributions arising from strange quark distributions and from charge symmetry violating parton distributions. We find that additional corrections from strange quarks and parton charge symmetry violation are likely to have a small but potentially significant role in decreasing the current discrepancy between the experimental and theoretical estimates of the Gross-Llewellyn Smith sum rule.

Londergan, J. T.; Thomas, A. W.

2010-12-01

185

Angular radiation pattern of Smith-Purcell radiation  

SciTech Connect

The power radiation pattern of Smith-Purcell radiation is measured at various latitudes and azimuth angles relative to the electron beam. The experimental data are used to evaluate the various models and the physical mechanisms previously suggested to describe Smith-Purcell radiation. Good agreement is observed between the experimental data and the theoretical curves derive from Van den Berg's analysis (J. Opt. Soc. Am. 63, 1588 (1973)). The radiation mechanism proposed by Salisbury (J. Opt. Soc. Am. 60, 1279 (1970)) was analyzed an shown to be too small to account for the measured radiation. The experimantal and Van den Berg's theory predict stronger emission at azimuthal angles off the plane perpendicular to the gratings. This observation leads to conclusions regarding the design of optical cavities for Smith-Purcell free-electron lasers and orotron millimeter-wavelength-radiation tube devices.

Gover, A.; Dvorkis, P.; Elisha, U.

1984-10-01

186

Searching for Star Formation in the Smith Cloud  

NASA Astrophysics Data System (ADS)

Recent discoveries of star formation in regions previously thought impossible implies new criteria for where stars can form. The Smith Cloud, a high velocity cloud (HVC) primarily comprised of neutral hydrogen located 12 kpc away in the halo of the Milky Way, meets these criteria by having a large reservoir of gas and the tidal pull of the Milky Way as a mechanism for perturbing the gas. We obtained GALEX NUV magnitudes for stars in the field of the Smith Cloud. These sources were matched with WISE and 2MASS catalogs to obtain infrared magnitudes. We determined the expected colors of young stars in these wavelength bands using synthetic spectral libraries. By comparing the observed UV and IR colors of stars to the expected colors of young stars, while also comparing star positions to existing 21cm data, we aim to isolate possible recent star formation in the Smith Cloud.

Baker, Ashley; Stark, D.; Kannappan, S.

2013-01-01

187

Description of floodplains and wetlands, Deaf Smith County site, Texas  

SciTech Connect

Floodplains and wetlands are important features of the Texas Panhandle landscape, and are found on the Deaf Smith County site and in its vicinity. Use or disturbance of floodplains and wetlands in relation to the Civilian Radioactive Waste Management Program is subject to environmental review requirements implementing two Executive Orders. This report provides general information on playa wetlands in the Texas Panhandle, and describes and maps floodplains and wetlands on the Deaf Smith site and in its vicinity. The report is based on the published literature, with information from limited field reconnaissance included.

Not Available

1986-11-01

188

Electron Bunch Length Diagnostic With Coherent Smith-Purcell Radiation  

SciTech Connect

The authors have designed a new technique for measuring subpicosecond electron bunch lengths using coherent Smith-Purcell radiation. This new diagnostic technique involves passing the electron beam in close proximity of a grating with a period comparable to the electron bunch length. The emitted Smith-Purcell radiation will have a coherent component whose angular position and distribution are directly related to the electron bunch length and longitudinal profile, respectively. This new diagnostic technique is inherently simple, inexpensive and non-intercepting. The authors show that the new technique is also scaleable to femtosecond regime.

Nguyen, D.C.

1997-05-12

189

77 FR 58181 - Power Resources, Inc., Smith Ranch Highland Uranium Project; License Renewal Request, Opportunity...  

Federal Register 2010, 2011, 2012, 2013

...Resources, Inc., Smith Ranch Highland Uranium Project; License Renewal Request, Opportunity...referenced. The Smith Ranch Highland Uranium Project license renewal request is available...Mandeville, Senior Project Manager, Uranium Recovery Licensing Branch, Division...

2012-09-19

190

System Info - 119947 SMITH, MICHAEL J 12-Feb-2010 16:45 ...  

Center for Biologics Evaluation and Research (CBER)

Text VersionPage 1. System Info - 119947 SMITH, MICHAEL J 12-Feb-2010 16:45:43 SMITHM RECORD ... Author: MICHAEL SMITH Telecon ... More results from www.fda.gov/downloads/biologicsbloodvaccines/vaccines

191

CRCHD - CRCHD Research - Principal Investigator: Mary A. Smith, Ph.D., M.S.  

Cancer.gov

Dr. Smith’s research projects focus on bioinformatics analysis of nuclear hormone receptors, with specific emphasis on the peroxisome proliferator-activated receptor and retinoid X receptor proteins, regulation, mechanisms of action and implications for obesity and related diseases.

192

Pharmacological Cognitive Enhancers: Comment on Smith and Farah (2011)  

ERIC Educational Resources Information Center

|Smith and Farah (2011) provided a thought-provoking and perhaps deliberately provocative literature review of the use of stimulants to improve cognitive functioning in humans. They addressed the apparently increasing willingness of individuals mostly in the United States to use stimulants for this purpose and then summarized published literature…

Elliott, Glen R.; Elliott, Mark D.

2011-01-01

193

Phenotype and Natural History in Marshall-Smith Syndrome  

Microsoft Academic Search

Marshall-Smith syndrome (MSS) is a distinctive entity of unknown etiology with fewer than 50 patients described in the medical literature to date. Through an International collaboration and use of an online wiki to facilitate data collection and sharing, we further delineate the phenotype and natural history of this syndrome. We present 15 new patients, the oldest being 30 years, provide

A. C. Shaw; Balkom van I. D. C; M. Bauer; T. R. P. Cole; M. A. Delrue; Haeringen van A; E. Holmberg; S. J. L. Knight; G. Mortier; S. Nampoothiri; S. Pušelji?; M. Zenker; V. Cormier-Daire; R. C. M. Hennekam

2010-01-01

194

Looking east at canal and R. Paul Smith Power Station. ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Looking east at canal and R. Paul Smith Power Station. The dark trestle at right center carried the spur track to coal unloading facilities located in the space now occupied by the coal pile. - Potomac Edison Company, Chesapeake & Ohio Canal Bridge, Spanning C & O Canal South of U.S. 11, Williamsport, Washington County, MD

195

Smith and Valley-Gray to Lead NASP  

ERIC Educational Resources Information Center

|The 2011 elections are complete and Amy Smith has been elected to lead NASP in 2012. Amy has a long history of serving her state and national professional organizations, most recently as NASP program manager for advocacy and before that as the Pennsylvania delegate and Northeast Region delegate representative. She served the Association of School…

Deupree, Charles

2011-01-01

196

Obituary: Harding Eugene (Gene) Smith, Jr., 1947-2007  

Microsoft Academic Search

Harding Eugene Smith Junior, or Gene, as he was known to family, friends, and colleagues, passed away after an automobile accident in Encinitas, California, on 16 August 2007. He was 60 years old. Gene had recently retired from UCSD after thirty years of service. A memorial service was held at Quail Botanical Gardens in Encinitas, California, on 23 August 2007.

Carol Lonsdale; Tom Soifer

2009-01-01

197

The Garrett Lee Smith Memorial Suicide Prevention Program  

ERIC Educational Resources Information Center

|In response to calls for greater efforts to reduce youth suicide, the Garrett Lee Smith (GLS) Memorial Act has provided funding for 68 state, territory, and tribal community grants, and 74 college campus grants for suicide prevention efforts. Suicide prevention activities supported by GLS grantees have included education, training programs…

Goldston, David B.; Walrath, Christine M.; McKeon, Richard; Puddy, Richard W.; Lubell, Keri M.; Potter, Lloyd B.; Rodi, Michael S.

2010-01-01

198

Smith-Magenis Syndrome: Genetic Basis and Clinical Implications  

ERIC Educational Resources Information Center

|Smith-Magenis syndrome (SMS) is a neurobehavioral disorder associated with deletions and mutations of the "RAI1" gene on chromosome 17p11.2. Clinical features of the syndrome include intellectual disability, sleep disturbance, craniofacial differences, and a distinctive profile of stereotypic and self-injurious behaviors. Although the functional…

Finucane, Brenda; Haas-Givler, Barbara

2009-01-01

199

Stability properties of Smith dead-time compensator controllers  

Microsoft Academic Search

The special stability properties of SISO systems incorporating Smith dead-time compensator controllers are investigated. It is shown that the conventional approach to the design of such systems may lead to practical instabilities. Necessary conditions for practical stability and sufficient conditions guaranteeing certain sensitivity and relative stability properties are stated and proven. The inaccuracies in the models are measured by means

Z. PALMOR

1980-01-01

200

Quantum Theory of the Smith-Purcell Experiment.  

National Technical Information Service (NTIS)

A relativistic quantum-mechanical treatment is given to explain the observations of Smith and Purcell on the emission of light by an electron beam in the presence of a diffraction grating. The dependence of the fundamental wavelength and its harmonics upo...

S. J. Glass H. Mendlowitz

1968-01-01

201

Forward Directed Smith-Purcell Radiation from Relativistic Electrons.  

National Technical Information Service (NTIS)

The requirements for the generation of forward directed Smith Purcell emission from relativistic electrons are introduced, and the first experimental evidence of this phenomenon is presented. The experiments were conducted with a 2.8 MeV/c electron beam i...

K. J. Woods J. E. Walsh R. E. Stoner H. G. Kirk R. C. Fernow

1995-01-01

202

Exponential gain in a Smith--Purcell amplifier  

SciTech Connect

We study here the gain of an amplifier based on the Smith--Purcell effect. The grating is characterized by a reflection matrix and the gain, in the exponential region, is calculated as a function of the beam height and thickness.

Schaechter, L.; Ron, A.

1988-09-05

203

The 'grove of death' in Pauline Smith's 'The Miller  

Microsoft Academic Search

For some time now critics have been interested in Pauline Smith's use of space and spatialisation. During the 80s in particular this interest was couched in terms of the 'world' of her work: the 'world' she was said to create or construct by writing. Her fiction was read as generated out of the narrative choices she makes, and evaluated (and

Myrtle Hooper

204

Pharmacological Cognitive Enhancers: Comment on Smith and Farah (2011)  

Microsoft Academic Search

Smith and Farah (2011) provided a thought-provoking and perhaps deliberately provocative literature review of the use of stimulants to improve cognitive functioning in humans. They addressed the apparently increasing willingness of individuals mostly in the United States to use stimulants for this purpose and then summarized published literature that explores whether stimulants actually improve specific aspects of neurocognitive function. Although

Glen R. Elliott; Mark D. Elliott

2011-01-01

205

TROPHIC DYNAMICS OF STRIPED BASS IN SMITH MOUNTAIN LAKE, VIRGINIA  

EPA Science Inventory

We examined the adequacy of the forage base to meet demand of striped bass in Smith Mountain Lake, Virginia. In regards to prey supply, mean alewife biomass from 1993-1998 was 37 kg/ha and mean gizzard shad biomass from 1990-1997 was 112 kg/ha. Mean annual alewife surplus produ...

206

Far infrared Smith Purcell experiment: measurement of radiated power  

NASA Astrophysics Data System (ADS)

Infrared radiation produced by a fully relativistic, 3.6 MeV, electron beam passing close to a metal grating has been observed and the radiated power estimated by direct comparison with a high pressure mercury vapour lamp. The dependence of wavelength on angle of emission, over angles from 56° to 150° and wavelengths from 350 ?m to 1860 ?m, agrees remarkably well with the Smith Purcell dispersion relation. The observed radiated power of about 10 ?W/cm2 sr A for a 100 ?m band width at a wavelength of 1 mm is comparable with or greater than that typical for infrared beam lines at synchrotrons, and also suggests that the Smith Purcell mechanism deserves greater attention as a possible basis for FEL operation in the mm and sub-mm wavelength bands.

Doucas, G.; Mulvey, J. H.; Omori, M.; Walsh, J.; Kimmitt, M. F.

1993-07-01

207

Fenimore Art Museum: The Smith and Telfer Photographic Collection  

NSDL National Science Digital Library

The Fenimore Art Museum in New York has a wide-ranging collection that includes significant pieces of American Indian art, folk art, and thousands of photographs and negatives. Working together with other institutions, including the New York State Historical Association, they have digitized over 300 images from the Smith and Telfer Photographic Collection. The firm of Smith and Telfer documented the town of Cooperstown, NY for well over a century, and they took photos of circus animals, civic monuments, and prominent individuals. Visitors can browse through the images at their leisure, and they can also search the entire collection by keyword. A couple of images of note include the shot of a man holding a dog in his lap while sitting on a tractor ("Ainslie Cornfield") and the photo entitled "Balloon Ascension".

208

Smith-Magenis Syndrome: Genetic Basis and Clinical Implications  

Microsoft Academic Search

Smith-Magenis syndrome (SMS) is a neurobehavioral disorder associated with deletions and mutations of the RAI1 gene on chromosome 17p11.2. Clinical features of the syndrome include intellectual disability, sleep disturbance, craniofacial differences, and a distinctive profile of stereotypic and self-injurious behaviors. Although the functional role of RAI1 and neighboring genes is not completely understood, disruption of these genes is thought to

Brenda Finucane; Barbara Haas-Givler

2009-01-01

209

X-ray generation by the Smith-Purcell effect  

SciTech Connect

Smith-Purcell (S-P) radiation is produced when electrons graze the surface of a grating. Calculations based on the theory of diffraction radiation show that, given severe restrictions on {ital e}{sup {minus}}-beam quality, S-P radiation is highly efficient. Efficient S-P x-ray generation requires relativistic {ital e}{sup {minus}} beams having a transverse momentum and dimension whose product approaches the Heisenberg uncertainty limit.

Moran, M.J. (Lawrence Livermore National Laboratory, University of California L-41, P.O. Box 808, Livermore, California 94550 (United States))

1992-10-26

210

Smith-Purcell free electron laser with variable grating period  

SciTech Connect

In this article, the principle of the FEL using the Smith-Purcell effect is discussed. The influence of using a grating with variable spacing upon radiation is studied. The calculation shows that if such a grating is adopted and its operating parameters are selected properly, the threshold value for the pumping electric current intensity is expected to decrease and the radiation power to increase.

CHEN Jianwen; FU Shufen; ZHANG Dake

1985-01-01

211

Smith-Purcell free electron laser with variable grating period  

SciTech Connect

In this article, the principle of the FEL using the Smith-Purcell effect is discussed. The influence of using a grating with variable spacing upon radiation is studied. The calculation shows that if such a grating is adopted and its operating parameters are selected properly, the threshold value for the pumping electric current intensity is expected to decrease and the radiation power to increase. 8 references.

Chen, J.; Fu, S.; Zhang, D.

1985-03-01

212

Optimization of parameters of Smith-Purcell BWO.  

SciTech Connect

We study the dependence of start current in Smith-Purcell backwardwave oscillator (SP-BWO) on grating parameters and electron beam parameters. The attenuation due to finite conductivity of the grating material is taken into account and three-dimensional effects are included in an approximate way in the analysis. We find that the start current can be significantly reduced by optimizing the grating parameters.

Kumar, V.; Kim, K.-J.; Accelerator Systems Division (APS); RRCAT

2006-01-01

213

Building Energy Audit Report for Camp Smith, HI  

SciTech Connect

A detailed energy assessment was performed by a team of engineers from Pacific Northwest National Laboratory (PNNL) under contract to the Department of Energy/Federal Energy Management program (FEMP). The effort used the Facility Energy Decision System (FEDS) model to determine how energy is consumed at Camp Smith, identify the most cost-effective energy retrofit measures, and calculate the potential energy and cost savings. This report documents the results of that assessment.

Chvala, William D.; De La Rosa, Marcus I.; Brown, Daryl R.; Dixon, Douglas R.

2010-09-30

214

Effect of vasopressin on the expression of genes for key enzymes of hyaluronan turnover in Wistar Albino Glaxo and Brattleboro rat kidneys.  

PubMed

Hyaluronan (HA), the major glycosaminoglycan of the interstitial matrix, is heterogeneously distributed within the kidney. Using real-time RT-PCR, we tested the assumption that renal HA may be involved in the long-term effect of vasopressin on water reabsorption. The expression of the genes encoding hyaluronan synthase-2 (Has2), hyaluronidase-1 and hyaluronidase-2 (Hyal1 and Hyal2) was studied in the kidneys of Wistar Albino Glaxo (WAG) and homozygous vasopressin-deficient Brattleboro rats treated with the V2 receptor-selective vasopressin analogue dDAVP (100 ?g (kg body wt)(-1), i.p., twice a day for 2 days). The Has2 mRNA content was the highest in the kidney papilla of the hydrated WAG and control Brattleboro rats, devoid of vasopressin. In WAG rats, dDAVP induced a considerable decrease in Has2 mRNA content in the papilla, with less pronounced changes in the cortex. The changes elicited by dDAVP in Brattleboro rats tended to be the same as in WAG rats, but weaker. In contrast to Has2, dDAVP treatment caused a significant increase in the Hyal1 and Hyal2 mRNA content in the renal papilla of WAG and Brattleboro rats. In rats of both strains, there was a good fit between Hyal1 and Hyal2 transcriptional levels and changes in hyaluronidase activity in the renal tissue. It is suggested that vasopressin is able to inhibit the synthesis of HA and concomitantly promote its degradation in the interstitium of the renal papilla, thereby facilitating water flow between elements of the renal countercurrent system. The implications for this effect are discussed in the context of the data in the literature. PMID:23955305

Ivanova, Lyudmila N; Babina, Alina V; Baturina, Galina S; Katkova, Lyubov E

2013-08-16

215

Uridine modulates neuronal activity and inhibits spike-wave discharges of absence epileptic Long Evans and Wistar Albino Glaxo/Rijswijk rats.  

PubMed

Pharmacological and functional data suggest the existence of uridine (Urd) receptors in the central nervous system (CNS). In the present study, simultaneous extracellular single unit recording and microiontophoretic injection of the pyrimidine nucleoside Urd was used to provide evidence for the presence of Urd-sensitive neurons in the thalamus and the cerebral cortex of Long Evans rats. Twenty-two neurons in the thalamus (24% of recorded neurons) and 17 neurons in the cortex (55%) responded to the direct iontophoresis of Urd. The majority of Urd-sensitive neurons in the thalamus and cortex (82% and 59%, respectively) increased their firing rate in response to Urd. In contrary, adenosine (Ado) and uridine 5'-triphosphate (UTP) decreased the firing rate of all responding neurons in the thalamus, and the majority of responding neurons in the cortex (83% and 87%, respectively). Functional relevance of Urd-sensitive neurons was investigated in spontaneously epileptic freely moving Long Evans and Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats. Intraperitoneal (i.p.) injection of 500mg/kg Urd decreased epileptic activity (210-270min after injection) in both rat strains. Intraperitoneal administration of 1000mg/kg Urd decreased the number of spike-wave discharges (SWDs) between 150-270min and 90-270min in Long Evans and WAG/Rij rats, respectively. The effect of Urd was long-lasting in both rat strains as the higher dose significantly decreased the number of SWDs even 24h after Urd injection. The present results suggest that Urd-sensitive neurons in the thalamus and the cerebral cortex may play a role in the antiepileptic action of Urd possibly via modulation of thalamocortical neuronal circuits. PMID:23707857

Kovács, Zsolt; Slézia, Andrea; Bali, Zsolt Kristóf; Kovács, Péter; Dobolyi, Arpád; Szikra, Tamás; Hernádi, István; Juhász, Gábor

2013-05-23

216

Adam Smith and Immanuel Kant: On Markets, Duties, and Moral Sentiments  

Microsoft Academic Search

This note points out a neglected parallel between the philosophies of Adam Smith and Immanuel Kant related to their views\\u000a on self-interest, morality, and society. First, I explain the distinction between Kant’s perfect and imperfect duties, and\\u000a how they result from his moral philosophy. Next, I summarize Smith’s two major perspectives on human behavior, as presented\\u000a in The Theory of

Mark D. White

2010-01-01

217

Design of adaptive Fuzzy-Smith controller based on improved genetic algorithm  

Microsoft Academic Search

For the complex controlled object with time-delay and time-varying, this paper presents an adaptive Fuzzy-Smith control system, combining the fuzzy logic controller optimized by Genetic algorithms with the Smith Predictor. The least-square parameter online identification technology is adopted to accomplish the self-adjusting of Smith Predictor according to the parameters variation of the object model. Meanwhile, the improved genetic algorithm adjusts

Hua Li; Qiu Ma

2010-01-01

218

Three-dimensional simulation of super-radiant Smith-Purcell radiation  

SciTech Connect

A simulation of coherent and super-radiant Smith-Purcell radiation is performed in the gigahertz regime using a three-dimensional particle-in-cell code. The simulation model supposes a rectangular grating to be driven by a single electron bunch and a train of periodic bunches, respectively. The true Smith-Purcell radiation is distinguished from the evanescent wave, which has an angle independent frequency lower than the minimum allowed Smith-Purcell frequency. We also find that the super-radiant radiations excited by periodic bunches are emitted at higher harmonics of the bunching frequency and at the corresponding Smith-Purcell angles.

Li, D.; Imasaki, K.; Yang, Z.; Park, Gun-Sik [Institute for Laser Technology, 2-6 Yamada-oka, Suita, Osaka 565-0871 (Japan); Institute of High-Energy Electronics, University of Electronic Science and Technology of China, Chengdu 610054 (China); School of Physics, Seoul National University, Seoul 151-747 (Korea, Republic of)

2006-05-15

219

Kitchen surgery and house calls in old Fort Smith.  

PubMed

Medical practice in the late nineteenth and early twentieth centuries consisted largely of kitchen surgery and house calls. The practices of Dr. St. Cloud Cooper and other Fort Smith doctors reflected the standards of practice in Arkansas and the nation as the principles of aseptic surgery gradually gained acceptance. The doctor's black bag used on house calls still lacked the effective agents which became available during the mid-twentieth century, leaving the physician to rely on personal inner resources in order to perform a useful service. PMID:24079057

Prewitt, Taylor

2013-09-01

220

Analysis of super-radiant Smith-Purcell emission  

SciTech Connect

Smith-Purcell emission is studied for a system with no incident field or electromagnetic feedback mechanism other than what is provided by the grating itself. A model is developed that analyzes the interaction between the electron beam and the grating electromagnetic modes. The system of equations is solved numerically, demonstrating linear emitted power versus current at low current levels and super-radiant power emission at higher currents. These results are compared to the previously published experimental data, and the model is used to gain some understanding of the physical mechanisms at work.

Flory, Curt A. [Agilent Laboratories, Palo Alto, California 94304 (United States)

2006-03-01

221

Forward directed Smith-Purcell radiation from relativistic electrons  

SciTech Connect

The requirements for the generation of forward directed Smith-Purcell emission from relativistic electrons are introduced, and the first experimental evidence of this phenomenon is presented. The experiments were conducted with a 2.8 MeV/{ital c} electron beam interacting with a 1 cm period grating. Radiation emitted in two bands with wavelengths ranging from 600 to 650 {mu}m and 1.2 to 1.7 mm were measured. Grating period to wavelength ratios were as high as 16. The measured intensities are higher than that predicted by incoherent emission.

Woods, K.J.; Walsh, J.E. [Department of Physics and Astronomy, Dartmouth College, Hanover, New Hampshire 03755 (United States); Stoner, R.E. [Massachusetts Institute of Technology and Research Laboratory of Electronics, Cambridge, Massachusetts 02139 (United States); Kirk, H.G.; Fernow, R.C. [Department of Physics, Brookhaven National Laboratory, Upton, New York 11973 (United States)

1995-05-08

222

Modelling the joint torques and loadings during squatting at the Smith machine  

Microsoft Academic Search

An analytical biomechanical model was developed to establish the relevant properties of the Smith squat exercise, and the main differences from the free barbell squat. The Smith squat may be largely patterned to modulate the distributions of muscle activities and joint loadings. For a given value of the included knee angle (?knee), bending the trunk forward, moving the feet forward

Andrea Biscarini; Paolo Benvenuti; Fabio Botti; Francesco Mastrandrea; Silvano Zanuso

2011-01-01

223

Active Queue Management Controller using Smith Predictor for Time Delay Networks  

Microsoft Academic Search

This paper presents an investigation into a robust controller for active queue management (AQM) using Smith predictor (SP). A new SP random early detector (RED) controller is proposed and compared with traditional RED based controller. It is worth noting that the RED controller is augmented by a Smith predictor structure for plants with medium and high time delays. The proposed

Rafe Khalaf Alasem; M. Alamgir Hossain; Irfan-ullah Awan

2007-01-01

224

Unconscious Odour Conditioning 25 Years Later: Revisiting and Extending "Kirk-Smith, Van Toller and Dodd"  

ERIC Educational Resources Information Center

|The pioneering work by Kirk-Smith, Van Toller, and Dodd [Kirk-Smith, M. D., Van Toller, C., & Dodd, G. H. (1983). "Unconscious odour conditioning in human subjects." "Biological Psychology," 17, 221-231], established that an unnoticed odorant paired with an emotionally meaningful task can influence mood and attitudes when the odorant alone is…

Zucco, Gesualdo M.; Paolini, Michela; Schaal, Benoist

2009-01-01

225

Smith Prediction Monitor AGC System Based on Fuzzy Self-Tuning PID Control  

Microsoft Academic Search

In accordance with the feature of pure delay in monitor AGC system for cold rolling mill, a new fuzzy self-tuning PID Smith prediction controller is developed. The position control model is deduced based on a single stand cold rolling mill, and the fuzzy controller for monitor AGC system is designed. The analysis of dynamic performance for traditional PID Smith prediction

Jie SUN; Dian-hua ZHANG; Xu LI; Jin ZHANG; De-shun DU

2010-01-01

226

A Disciplinary Immigrant. Alexander Smith at the University of Chicago, 1894-1911  

ERIC Educational Resources Information Center

|The publication in 1906 of Alexander Smith's "Introduction to general inorganic chemistry" inaugurated a decisive change in chemical pedagogy in the US, the effects of which are still evident. The nature and extent of Smith's innovations are described through a comparison of his text to its source material and contemporaries. His authoritative…

Cotter, Donald

2008-01-01

227

THE HAPPY MARRIAGE: THE INFLUENCE OF CHARLOTTE SMITH ON JANE AUSTEN  

Microsoft Academic Search

All of Jane Austen's fiction shows the repeated influence of Charlotte Smith's nine novels. In the Juvenilia Jane Austen openly exploited Charlotte Smith's Emmeline and Ethelinde more closely than she was ever to use any other novels, referring to them as the prototype of popular current literature. Although Frank W. Bradbrook has noted a few verbal echoes of Emmeline and

WILLIAM H. MAGEE

1975-01-01

228

Bottling the Imagination: Writing as Metamorphosis in Ali Smith's Girl Meets Boy  

Microsoft Academic Search

This article discusses ideas about creativity in the context of a recent work by Ali Smith, Girl Meets Boy. It follows Pope in theorising a view of creativity that sees it as re-creation and demonstrates the extent to which the context in which Smith's novel is produced, as well as the acknowledged sources underlying it, helps to shape it as

Fiona Doloughan

2010-01-01

229

Speech/Language Pathologists Reflect on Sally Smith and the Lab School of Washington  

ERIC Educational Resources Information Center

|Sally L. Smith had a clear vision of how she thought speech and language services should be integrated into her school, The Lab School of Washington. It was Smith's idea that language therapists should work individually with students to help them make gains in their particular areas of need, as well as to work collaboratively with the teachers,…

Learning Disabilities: A Multidisciplinary Journal, 2010

2010-01-01

230

FIFTY YEARS OF MARINE FISH SYSTEMATICS AT THE J.L.B. SMITH INSTITUTE OF ICHTHYOLOGY  

Microsoft Academic Search

In 1946 Rhodes University created the Department of Ichthyology with J.L.B. Smith at the helm. Smith's research centred on the fishes of South Africa and the Western Indian Ocean. In his 22 years at the Department he produced the Sea Fishes of Southern Africa (SFSA) and revised numerous taxa based on material collected during his frequent trips to various parts

Ofer Gon

1996-01-01

231

SYMPATHY, DIFFERENCE, AND EDUCATION: SOCIAL UNITY IN THE WORK OF ADAM SMITH  

Microsoft Academic Search

In this article, I examine Adam Smith s theory of the ways individuals in society bridge social and biological difference. In doing so, I emphasize the divisive effects of gender, race, and class to see if Smith s account of social unity can overcome such fractious forces. My discussion uses the metaphor of proximity to mean both physical and psychological

JACK RUSSELL WEINSTEIN

2006-01-01

232

Restoring Free Exercise Protections by Limiting Them: Preventing a Repeat of Smith  

Microsoft Academic Search

Employment Division, Department of Human Resources of Oregon v. Smith effectively removed all protections traditionally accorded the free exercise of religion. RFRA was designed to undo the effects of this decision by presumably setting back the clock of jurisprudence to the day before Smith. Even if RFRA is found to be constitutional, it will still, of itself, be ultimately ineffective

James M Donovan

1996-01-01

233

ADAM SMITH AND THE ROLE OF THE METAPHOR OF AN INVISIBLE HAND  

Microsoft Academic Search

Daniel Klein and Brandon Lucas's In a Word or Two, Placed in the Middle: The Invisible Hand in Smith's Tomes, following a vague hint by Peter Minowitz (2004), offers original physical evidence that Smith deliberately placed the phrase led by an invisible hand- at the physical centre of both his masterworks. Further, it suggests that the invisible-hand paragraphs are a

Gavin Kennedy

2011-01-01

234

Mitigation Case Studies: Hardened First Responder Facility. 911 Communication and Emergency Operations Center, Smith County, Texas.  

National Technical Information Service (NTIS)

Smith County is located in east Texas, approximately 100 miles east of Dallas. It is largely rural, with only one metropolitan area, the City of Tyler. The Sheriff of Smith County and the Police Chief of the City of Tyler saw a need for a consolidated eme...

2003-01-01

235

In search of the physical: George Adam Smith's journeys to palestine and their importance  

Microsoft Academic Search

By any standard, George Adam Smith's was a remarkable career. Having established a reputation for himself as the first minister of a new congregation of the Free Church of Scotland in the west of Aberdeen, where he consolidated his liberal evangelical pulpit between 1882 and 1892, Smith went on to become a foremost Old Testament scholar in the Free Church

Iain D. Campbell

2002-01-01

236

“These Dark Woods Yet Again”: Rewriting Redemption in Lee Smith's Saving Grace  

Microsoft Academic Search

Lee Smith recently commented, “In a way my writing is a lifelong search for belief. I have always been particularly interested in expressions of religious ecstasy, and in those moments when we are most truly ‘out of ourselves’ and experience the Spirit directly” (“Notes,” Saving). In more than ten novels and short story collections, Smith has explored aspects of Southern

Jacqueline Doyle

2000-01-01

237

Obituary: Harding Eugene (Gene) Smith, Jr., 1947-2007  

NASA Astrophysics Data System (ADS)

Harding Eugene Smith Junior, or Gene, as he was known to family, friends, and colleagues, passed away after an automobile accident in Encinitas, California, on 16 August 2007. He was 60 years old. Gene had recently retired from UCSD after thirty years of service. A memorial service was held at Quail Botanical Gardens in Encinitas, California, on 23 August 2007. A web page is dedicated to his memory at http://harding.smith.muchloved.com, where contributions of memories are invited. Gene was born in San Jose, California in 1947, to Harding Eugene Smith Senior, and Bernice Smith (nee Smith). Harding Smith Senior was an air-force navigator; therefore Gene spent his childhood moving from one air-force base to another. Although an only child, Gene was very close to his cousin Meg, whom he lived nearby to in Gilroy for a time, and the two were like brother and sister. The elder Harding Smith was lost in action over Cambodia in the mid-sixties. Gene was a dedicated student, a boy scout, and a Presidential Scholar. He majored in Physics at Caltech, where he also took a lively interest in the football team and the Glee Club, and was elected a House Officer. To his close friends, he was known at Caltech as Smitty, and the closest of them was Rob Drew, who gave a glimpse into that period of Gene's life at the memorial: "Gene arrived early at campus his first year, in response to an invitation to join the football team. Gene's size and features reminded the head coach of a long-forgotten player named 'Johnson.' After a few days of confusion, Gene simply replaced the name on his helmet. 'Johnson!' coach would yell, 'get in there!' If Johnson was going to get to play, Gene was going to be the best Johnson available!" Gene spent the summer of 1966 working at Kitt Peak, where his lifetime love of observing with ground-based telescopes began, though he learned some things the hard way, such as the fact that trying to squeeze 40,000 numbers onto a computer that stored only 32,000 resulted in blown fuses. In a final letter of that summer back to Drew he wrote: "My summer is now complete. I have achieved the highest pinnacle in my quest for fulfillment. Striking a blow for humanity I just blew the whole Kitt Peak CDC3200 computer system. Those fuses were nothing compared to this!" Gene's graduate work, on the metal abundances in HII regions of nearby galaxies, was done at Berkeley, where Hyron Spinrad was his thesis advisor. He loved observing and spent numerous fun nights at Lick, Kitt Peak, Cerro Tololo, Keck, and many other observatories. He joined Margaret Burbidge at UCSD for a postdoctoral fellowship, and joined the teaching faculty there in 1978. Gene spent his entire professional career at UCSD. His research ranged from the study of quasar absorptions lines to the astrophysics of Ultra-luminous Infrared Galaxies. He was a key participant in UC-wide astronomy support, including being the chair of the science-advisory committee for the Ten Meter Telescope project, which later "morphed" into the Keck Observatory. His contributions to enabling that project were both essential and unheralded. Gene was a dedicated and enthusiastic teacher. One of his favorite undergraduate classes gave him the opportunity to dress up in Renaissance garb and pretend to be Galileo, while the experiment most loved by his students was when they got to attempt to drop an egg on his head from several stories high. Gene was also an outstanding advisor and mentor, and both his first post-doc, Rick Puetter, and his last graduate student, Brian Siana, were able to attend his memorial service and provide some special memories of their experiences with him. Rick recalled a memorable trip to Cerro Tololo when they packed up two infrared spectrometers for the trip, and everything conceivable went wrong, from inspections at the airport to spectrometer parts broken on the plane and instrument failures at the observatory, to finally being completely clouded out. Brian recounted: "I spent countless cloudy nights listening to Gene's stories

Lonsdale, Carol; Soifer, Tom

2009-01-01

238

Circadian rhythm abnormalities of melatonin in Smith-Magenis syndrome  

PubMed Central

BACKGROUND—Smith-Magenis syndrome (SMS) is a multiple congenital anomalies/mental retardation syndrome associated with a hemizygous deletion of chromosome 17, band p11.2. Characteristic features include neurobehavioural abnormalities such as aggressive and self-injurious behaviour and significant sleep disturbances. The majority of patients have a common deletion characterised at the molecular level. Physical mapping studies indicate that all patients with the common deletion are haploinsufficient for subunit 3 of the COP9 signalosome (COPS3), which is conserved from plants to humans, and in the plant Arabidopis thaliana regulates gene transcription in response to light. Haploinsufficiency of this gene is hypothesised to be potentially involved in the sleep disturbances seen in these patients. Melatonin is a hormone secreted by the pineal gland. SMS patients are reported to have fewer sleep disturbances when given a night time dose of this sleep inducing hormone.?METHODS—Urinary excretion of 6-sulphatoxymelatonin (aMT6s), the major hepatic metabolite of melatonin, in 19 SMS patients were measured in conjunction with 24 hour sleep studies in 28 SMS patients. Five of the 28 patients did not have the common SMS deletion. To investigate a potential correlation of COPS3 haploinsufficiency and disturbed melatonin excretion, we performed fluorescence in situ hybridisation (FISH) using two BACs containing coding exons of COPS3.?RESULTS—All SMS patients show significant sleep disturbances when assessed by objective criteria. Abnormalities in the circadian rhythm of aMT6s were observed in all but one SMS patient. Interestingly this patient did not have the common deletion. All patients studied, including the one patient with a normal melatonin rhythm, were haploinsufficient for COPS3.?CONCLUSIONS—Our data indicate a disturbed circadian rhythm in melatonin and document the disturbed sleep pattern in Smith-Magenis syndrome. Our findings suggest that the abnormalities in the circadian rhythm of melatonin and altered sleep patterns could be secondary to aberrations in the production, secretion, distribution, or metabolism of melatonin; however, a direct role for COPS3 could not be established.???Keywords: melatonin; circadian rhythms; Smith-Magenis syndrome; COPS3

Potocki, L.; Glaze, D.; Tan, D.; Park, S.; Kashork, C.; Shaffer, L.; Reiter, R.; Lupski, J.

2000-01-01

239

Deaf Smith County noise analysis: Revision 2. [Contains glossary  

SciTech Connect

An analysis of activities proposed for the three major phases of development of the proposed nuclear waste repository site in Deaf Smith County, Texas, was conducted to quantify the noise levels and the effect of noise resulting from these activities. The report provides additional details of the predictive noise level modeling conducted for the site characterization, repository construction, and repository operation phases. Equivalent day/night sound levels are presented for each phase as sound level contours. Sound levels from onsite and offsite activities are addressed including traffic on access routes, and railroad construction and operation. A description of the predictive models, the analysis methodologies, the noise source inventories, the model outputs, and the evaluation criteria are included. 35 refs., 6 figs., 2 tabs.

Not Available

1985-11-01

240

Deaf Smith County air quality analysis: Letter report: Revision 2  

SciTech Connect

Air quality impacts due to site characterization, and repository construction and operation activities were evaluated in the Deaf Smith County Site, Texas environmental assessment (EA). The analyses on which the impact assessments are based made with dispersion models recommended by the EPA for such applications, meteorological data from a nearby representative National Weather Service station at Amarillo, Texas, and available background air quality data from an urban monitoring location. Maximum offsite concentrations of total suspended particulates, nitrogen dioxide, sulfur dioxide, and carbon monoxide were estimated for periods of maximum emissions identified for each pollutant. Estimates of total annual salt deposition resulting from repository salt handling operations were also made. 36 refs., 5 figs., 17 tabs.

Not Available

1985-11-01

241

Mulvihill-Smith syndrome: case report and review.  

PubMed Central

We report a 20 year old man with short stature, microcephaly, unusual facies, numerous pigmented naevi, hypodontia, immunodeficiency, and a high pitched voice. Tympner et al had assumed that the patient had a new syndrome of "progressive combined immunodeficiency and ectomesodermal dysplasia". We show here that the condition is identical to the Mulvihill-Smith syndrome (McKusick 176690), a progeroid disorder described in four or possibly five sporadic cases to date. We describe his clinical progress up to the age of 20 years. Our patient suffered from severe viral infections, allergic rhinitis and conjunctivitis, delayed puberty, visual loss, modest achievement in high school, and reactive depression. The immunological, facioskeletal, and dental abnormalities are presented in detail. Images

Bartsch, O; Tympner, K D; Schwinger, E; Gorlin, R J

1994-01-01

242

Adam Smith and the Evolutionist Theory of Institutions  

Microsoft Academic Search

L’oeuvre d’Adam Smith a pour objectif d’analyser l’aspect institutionnel des phénomènes sociaux. D’un côté, la Théorie des sentiments moraux trouve sa juste place dans la pensée de l’économiste écossais ; son rôle est d’expliquer comment se forment les jugements moraux individuels et comment ces jugements débouchent de façon évolutionniste sur l’émergence d’ institutions sociales. De l’autre côté, la véritable cause

Valentin Petkantchin

1996-01-01

243

Analysis of Smith-Purcell BWO with end reflections.  

SciTech Connect

We present a one-dimensional time-dependent analysis and simulation of Smith-Purcell (SP) backward wave oscillator (BWO) taking end reflections and attenuation into account. In the linear regime, we obtain an analytic solution and calculate the start current. The dependence of start current on end reflections is studied taking the attenuation due to finite conductivity into account. In this paper, we have set up Maxwell-Lorentz equations for the one-dimensional time-dependent analysis of SP-BWO including end reflection and attenuation due to finite conductivity. We have obtained a solution in the linear regime and extended the analysis to the nonlinear regime by solving the Maxwell-Lorentz equations numerically. Our analysis can be used for detailed optimization of outcoupled power and start current in SP-BWO taking end reflection and attenuation into account.

Kumar, V.; Kim, K.-J.; Accelerator Systems Division (APS); RRCAT

2006-01-01

244

Smith-Purcell radiation emission in aligned nanoparticles  

SciTech Connect

Smith-Purcell (SP) radiation produced by interaction of fast electron beams running parallel to strings of nanoparticles is investigated. Results for the radiation emission probability and electron energy loss spectra using finite and infinite strings of Al and silica spheres are presented. Both of these quantities are obtained by solving Maxwell's equations exactly using a multipole expansion approach. The response of the spheres is described in terms of their local frequency-dependent dielectric functions. In silica, the emission probability is seen to coincide with the energy loss probability within the gap region, where the solid cannot absorb any energy. Large emission rates are predicted for Al, suggesting its possible application in tunable soft uv light generation. The dependence of the emission on the size of the spheres, the string period, and the electron energy is discussed in detail. Finite size effects are also studied for strings of 1-15 Al spheres. (c) 2000 The American Physical Society.

Garcia de Abajo, F. J. [Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720 (United States)

2000-05-01

245

Recent insights into the Smith-Lemli-Opitz syndrome  

PubMed Central

The Smith–Lemli–Opitz syndrome (SLOS) is an autosomal recessive multiple congenital anomaly/mental retardation disorder caused by an inborn error of post-squalene cholesterol biosynthesis. Deficient cholesterol synthesis in SLOS is caused by inherited mutations of 3?-hydroxysterol-?7 reductase gene (DHCR7). DHCR7 deficiency impairs both cholesterol and desmosterol production, resulting in elevated 7DHC/8DHC levels, typically decreased cholesterol levels and, importantly, developmental dysmorphology. The discovery of SLOS has led to new questions regarding the role of the cholesterol biosynthesis pathway in human development. To date, a total of 121 different mutations have been identified in over 250 patients with SLOS who represent a continuum of clinical severity. Two genetic mouse models have been generated which recapitulate some of the developmental abnormalities of SLOS and have been useful in elucidating the pathogenesis. This mini review summarizes the recent insights into SLOS genetics, pathophysiology and potential therapeutic approaches for the treatment of SLOS.

Yu, H; Patel, SB

2005-01-01

246

Pharmacological cognitive enhancers: comment on Smith and Farah (2011).  

PubMed

Smith and Farah (2011) provided a thought-provoking and perhaps deliberately provocative literature review of the use of stimulants to improve cognitive functioning in humans. They addressed the apparently increasing willingness of individuals mostly in the United States to use stimulants for this purpose and then summarized published literature that explores whether stimulants actually improve specific aspects of neurocognitive function. Although calling for more research, they tentatively concluded that stimulants indeed may be "smart pills" for some people under certain circumstances. This comment emphasizes that they never actually defined the desired qualities of a smart pill, seemed to accept the unproven axiom that slight improvements in specific tests constitute meaningful enhancement of intelligence, and failed to consider the possible costs to individuals and to society of promoting the use of this class of medications for such a purpose. PMID:21859176

Elliott, Glen R; Elliott, Mark D

2011-09-01

247

Sophia Smith Collection: Population and Reproductive Health Oral History Project  

NSDL National Science Digital Library

Funded by the William and Flora Hewlett Foundation, the Population and Reproductive Health Oral History Project includes accounts of individuals throughout the world who have made valued contributions to the field. The materials here are part of the Women's History Archives at Smith College and the series includes the voices and perspectives of advocates, communication specialists, lawyers, managers, physicians, researchers, and social workers from the period 1965 to 2005. First-time visitors should read the Project History essay and then take a closer look at the several dozen interviews offered here. Those profiled here include the "mother of Asian demography," Mercedes Concepcion, and Lee Minto, the president of Planned Parenthood of Seattle-King County from 1967 to 1993. Other people interviewed here include Daniel E. Pellegrom, Nafis Sadik, and Sara Seims. It's a wonderful archive for persons interested in public health, women's studies, and a range of other crucial areas of academic study.

2013-05-16

248

Analysis of Smith-Purcell free-electron lasers  

SciTech Connect

We present an analysis of the beam dynamics in a Smith-Purcell free-electron laser (FEL). In this system, an electron beam interacts resonantly with a copropagating surface electromagnetic mode near the grating surface. The surface mode arises as a singularity in the frequency dependence of the reflection matrix. Since the surface mode is confined very close to the grating surface, the interaction is significant only if the electrons are moving very close to the grating surface. The group velocity of the surface mode resonantly interacting with a low-energy electron beam is in the direction opposite to the electron beam. The Smith-Purcell FEL is therefore a backward wave oscillator in which, if the beam current exceeds a certain threshold known as start current, the optical intensity grows to saturation even if no mirrors are employed for feedback. We derive the coupled Maxwell-Lorentz equations for describing the interaction between the surface mode and the electron beam, starting from the slowly varying approximation and the singularity in the reflection matrix. In the linear regime, we derive an analytic expression for the start current and calculate the growth rate of optical power in time. The analysis is extended to the nonlinear regime by performing a one-dimensional time-dependent numerical simulation. Results of our numerical calculation compare well with the analytic calculation in the linear regime and show saturation behavior in the nonlinear regime. We find that a significant amount of power grows in the surface mode due to this interaction. Several ways to outcouple this power to freely propagating modes are discussed.

Kumar, Vinit; Kim, Kwang-Je [Advanced Photon Source, Argonne National Laboratory, Argonne, Illinois 60439 (United States)

2006-02-15

249

Technology evaluation: C242-DM1, ImmunoGen Inc.  

PubMed

C242-DM1 is a tumor-activated immunotoxin under development by GlaxoSmithKline plc (formerly SmithKline Beecham plc), under licence from ImmunoGen Inc, as a potential treatment for colon tumor. It consists of a colon cancer-specific humanized antibody, C242, conjugated to the maytansine derivative DM1. In preclinical studies, C242-DM1 caused complete tumor regression in animal models of both human pancreatic and non-small cell lung cancer (NSCLC) at non-toxic doses. C242-DM1 has also been evaluated in an immunoconjugate combination with J-591 (Cornell University). The J591-DM1 immunoconjugate demonstrated effective, antigen-specific delivery of a highly cytotoxic drug to PSMA-positive Pca cells in vitro and in vivo with low systemic toxicity. Results from studies in monkeys showed that C242-DM1 had no significant toxicity or side effects, when administered at doses higher than those that were previously shown to completely eradicate human colon tumors in mice [271420]. ImmunoGen acquired the right to evaluate, and an option to license, technology related to maytansines from Takeda. In February 1999, ImmunoGen and SmithKline Beecham signed a US $45 million development and commercialization agreement for C242-DM1 [313493]. In August 1997, Immunogen received an SBIR grant to advance development of huC242-DM1 [258356]. EP-00425235, held by ImmunoGen, covers conjugated forms of ansamitocin (maytansine) derivatives. Takeda holds several patents for the production of ansamitocin and its analogs, the first one being JP-53124692. PMID:11338934

Smith, S

2001-04-01

250

Phospholipase A2 inhibitors in the treatment of atherosclerosis: a new approach moves forward in the clinic.  

PubMed

Phase II results of the trials of two phospholipase A2 inhibitors which may be of value in the treatment of atherosclerosis and cardiovascular disease have been reported in the past year. Darapladib (GlaxoSmithKline) is an inhibitor of lipoprotein-associated phospholipase A2 and varespladib (Anthera) inhibits several forms of the secreted phospholipase A2s. Despite the apparent similarity of mechanism, which is also built into the compounds' names, the role of the two types of phospholipase in atherogenesis is very different. Evidence for this comes from a range of preclinical studies and from epidemiological data which are summarised here. These data provide a basis for the Phase II studies and support decisions to move into Phase III, a decision which in the case of darapladib has been made and studies commenced (STABILITY trial). For varespladib the FRANCIS-ACS trial in acute coronary syndrome patients is in progress. PMID:19691442

Suckling, Keith E

2009-10-01

251

Seroxat and the suppression of clinical trial data: regulatory failure and the uses of legal ambiguity.  

PubMed

This article critically evaluates the Medicines and Healthcare products Regulatory Agency's announcement, in March 2008, that GlaxoSmithKline would not face prosecution for deliberately withholding trial data, which revealed not only that Seroxat was ineffective at treating childhood depression but also that it increased the risk of suicidal behaviour in this patient group. The decision not to prosecute followed a four and a half year investigation and was taken on the grounds that the law at the relevant time was insufficiently clear. This article assesses the existence of significant gaps in the duty of candour which had been assumed to exist between drugs companies and the regulator, and reflects upon what this episode tells us about the robustness, or otherwise, of the UK's regulation of medicines. PMID:19181884

McGoey, L; Jackson, E

2009-02-01

252

Casopitant, a neurokinin-1 receptor antagonist with anti-emetic and anti-nausea activities.  

PubMed

Casopitant, an inhibitor of the neurokinin-1 receptor, and its mesylate salt, are being developed by GlaxoSmithKline plc for the potential treatment of chemotherapy-induced nausea and vomiting (CINV), post-operative nausea and vomiting (PONV), as well as for anxiety, depression and insomnia. Phase II trials are ongoing for anxiety, depression and insomnia, and further results are awaited from phase III trials of CINV and PONV. At the time of publication, it was expected that applications to the FDA for regulatory approval for CINV and PONV would be filed in 2008. Casopitant was previously being developed for the treatment of overactive bladder; however, in September 2007, this indication was no longer listed on the company's product pipeline. PMID:18600583

Navari, Rudolph M

2008-07-01

253

3-Hydroxy-6,7-dihydropyrimido[2,1-c][1,4]oxazin-4(9H)-ones as new HIV-1 integrase inhibitors WO2011046873 A1.  

PubMed

Since the discovery of raltegravir, the first FDA-approved integrase inhibitor, Merck and other pharmaceutical companies have continued their research programs in order to introduce novel molecules as second generation integrase inhibitors. Elvitegravir (Japan Tobacco/Gilead) and dolutegravir (Shionogi/GlaxoSmithKline) are in advanced stages of clinical development. Bristol-Myers Squibb has developed molecules leading to BMS-707035, which was stopped at the Phase II clinical trial stage. Herein is presented the last patent from this company where, in particular, new 3-hydroxy-6,7-dihydropyrimido[2,1-c][1,4]oxazin-4(9H)-ones are synthesized and their biological properties given. PMID:21974685

Cotelle, Philippe

2011-10-06

254

Monovalent inactivated split-virion AS03-adjuvanted pandemic influenza A (H1N1) vaccine.  

PubMed

The first cases of pandemic influenza A (H1N1) 2009 infection were seen in Mexico in March 2009. Since then, it is thought to have been responsible for at least 18,337 deaths globally. Owing to the young age of fatalities, there have been an estimated 2 million years of life lost, which is comparable to the previous pandemics of 1957 and 1968. In this article, we consider the available data on a monovalent inactivated split-virion AS03-adjuvanted pandemic influenza A (H1N1) vaccine, Pandemrix™ (GlaxoSmithKline, Rixensart, Belgium). At present, Pandemrix appears to be highly immunogenic in all age groups, including children and infants under 3 years of age, with an acceptable safety profile in the context of an influenza pandemic. However, owing to the novel adjuvant, further studies on the safety, immunogenicity and vaccine effectiveness of Pandemrix together with robust post-marketing surveillance are required. PMID:21105775

Walker, Woolf T; Faust, Saul N

2010-12-01

255

Anaphylaxis following H1N1 pandemic vaccines: safety data in perspective.  

PubMed

We present here a detailed analysis of anaphylaxis cases reported to GlaxoSmithKline safety database following vaccination with its H1N1 pandemic influenza vaccines, Pandemrix™ and Arepanrix™. Cases were assessed according to the Brighton Collaboration Case Definition (BCCD) as either confirmed diagnosis (97/395, 24.6%), insufficient information to fulfil the minimal criteria of the case definition (117/395, 29.6%) or anaphylaxis excluded (181/395, 45.8%). There was no evidence that the rate of anaphylaxis following vaccination with Pandemrix™ or Arepanrix™ is increased with respect to the rates of anaphylaxis for other vaccines. Our analysis also highlighted the challenges of reliably determining the rate of anaphylaxis as an adverse event in the postmarketing setting following mass vaccination, as anaphylaxis was excluded in 45.8% of reported cases. PMID:21527305

Tavares, Fernanda; Delaigle, Aurelie; Slavin, Dorothy; Bauchau, Vincent; Fries, Louis; Seifert, Harry

2011-04-27

256

Asthma & COPD--IQPC's Second Conference.  

PubMed

The International Quality & Productivity Center's (IQPC) Second Asthma & COPD conference, held in Philadelphia, included topics covering new therapeutic developments in the field of asthma and COPD. This conference report highlights selected presentations on mAb treatments for asthma, including targeting IL-5, IL-13, IL-9 and TNFa, CCR3 inhibitors, histamine H4 receptor inhibition, novel mouse models of COPD and inhaled antisense asthma therapies. Investigational drugs discussed include mepolizumab (GlaxoSmithKline plc), benralizumab (BioWa Inc/Kyowa Hakko Kirin Co Ltd/MedImmune LLC), AMG-317 (Amgen Inc/Takeda Bio Development Center Ltd), TPI-ASM-8 (Pharmaxis Ltd) and AIR-645 (Altair Therapeutics Inc). PMID:20799138

Catley, Matthew C

2010-09-01

257

Development of a commercial Automated Laser Gas Interface (ALGI) for AMS  

NASA Astrophysics Data System (ADS)

National Electrostatics Corporation (NEC), Massachusetts Institute of Technology (MIT), and GlaxoSmithKline (GSK) collectively have been developing an interface to introduce CO2 produced by the laser combustion of liquid chromatograph eluate deposited on a CuO substrate directly into the ion source of an AMS system, thereby bypassing the customary graphitization process. The Automated Laser Gas Interface (ALGI) converts dried liquid samples to CO2 gas quickly and efficiently, allowing 96 samples to be measured in as little as 16 h. 14C:12C ratios stabilize typically within 2 min of analysis time per sample. Presented is the recent progress of NEC's ALGI, a stand-alone accessory to an NEC gas-enabled multi-cathode source of negative ions by Cs sputtering (MC-SNICS) ion source.

Daniel, R.; Mores, M.; Kitchen, R.; Sundquist, M.; Hauser, T.; Stodola, M.; Tannenbaum, S.; Skipper, P.; Liberman, R.; Young, G.; Corless, S.; Tucker, M.

2013-01-01

258

BAFF/BLyS inhibitors: A new prospect for treatment of systemic lupus erythematosus.  

PubMed

In November 2009, Human Genome Sciences and Glaxo-Smith Kline [HGS (Rockville, Maryland) and GSK, respectively] announced that Belimumab, a neutralizing antibody to the tumour necrosis factor (TNF)-like ligand, B-cell activating factor (BAFF belonging to the TNF family, also named BLyS), met the primary endpoints in two phase III clinical trials in systemic lupus erythematosus (SLE, lupus). In March 2011, Belimumab was approved by the US Federal Drug Agency for treatment of SLE patients; this was followed in May with approval by the European Medicines Agency for use in the European Union. This is an exciting development as it is the first successful late-stage clinical trial in SLE in over 40 years. In the light of this breakthrough, we review the key data and research outcomes and examine how blocking BAFF in patients with SLE significantly improves clinical outcomes. PMID:22641424

Fairfax, Kirsten; Mackay, Ian R; Mackay, Fabienne

2012-05-29

259

Radioimmunotherapy as a therapeutic option for Non-Hodgkin's lymphoma.  

PubMed

Radioimmunotherapy (RIT) represents a relatively new antibody-based radiopharmaceutical treatment for patients with various kinds of tumors. Although the field has a long history of preclinical and clinical investigations using many different agents, to date, only 2 of these immunologically targeted radiopharmaceuticals have been cleared for commercial sale. Both of these agents ((90)Y-ibritumomab tiuxetan or "Zevalin" [Biogen-Idec, Boston, MA] and (131)I-tositumomab or "Bexxar" [GlaxoSmithKline Research, Triangle Park, NC]) are directed against the CD20 surface antigen found on normal mature B cells and greater than 95% of B-cell non-Hodgkin lymphoma (NHL). Both compounds produce similar impressive clinical outcomes (approximately 20%-40% complete response rates and 60%-80% overall response rates for patients with indolent B-cell NHL). Current protocol-based investigations of anti-CD20 RIT relate to new clinical uses and new CD20(+) targets. PMID:17591564

Macklis, Roger M

2007-07-01

260

Stability of seasonal influenza vaccines investigated by spectroscopy and microscopy methods.  

PubMed

The stability of different seasonal influenza vaccines was investigated by spectroscopy and microscopy methods before and after the following stress-conditions: (i) 2 and 4 weeks storage at 25°C, (ii) 1 day storage at 37°C and (iii) one freeze-thaw cycle. The subunit vaccine Influvac (Solvay Pharma) and the split vaccine Mutagrip (Sanofi Pasteur) were affected by all stresses. The split vaccine Fluarix (GlaxoSmithKline) was affected only by storage at 25°C. The virosomal vaccine Inflexal V (Berna Biotech) was stable after the temperature stresses but aggregated after one freeze-thaw cycle. This study provides new insights into commercial vaccines of low antigen concentration and highlights the importance of using multiple techniques to assess vaccine stability. PMID:21803109

Patois, E; Capelle, M A H; Gurny, R; Arvinte, T

2011-07-29

261

Use of MenACWY-CRM in adolescents in the United States.  

PubMed

Adolescents constitute a high-risk group for invasive meningococcal disease. MenACWY-CRM (Menveo, Novartis Vaccines, Cambridge, MA) is a quadrivalent meningococcal conjugate vaccine indicated to prevent invasive meningococcal disease caused by Neisseria meningitidis serogroups A, C, W-135, and Y. It has been approved for use in persons age 2-55 years. The tolerability and immunogenicity of MenACWY-CRM in adolescents have been ascertained in phase 2 and 3 trials against MPSV4 (Menomune, sanofi pasteur, Swiftwater, PA), an unconjugated quadrivalent meningococcal vaccine, and MenACWY-D (Menactra, sanofi pasteur), another conjugated quadrivalent meningococcal vaccine. Clinical trials also have demonstrated that MenACWY-CRM is well tolerated and immunogenic when administered to adolescents concomitantly with the combined tetanus, diphtheria, and acellular pertussis vaccine (Boostrix, GlaxoSmithKline Biologicals, Rixensart, Belgium) and the quadrivalent human papillomavirus vaccine (Gardasil, Merck & Co., Inc., Whitehouse Station, NJ). PMID:23299001

Black, Steven; Block, Stan L

2012-09-25

262

The development of Lapdap, an affordable new treatment for malaria.  

PubMed

There is much discussion on how new drugs can be developed for use in developing countries at a price that makes them accessible to those who need them most. The development of a new antimalarial, chlorproguanil/dapsone (Lapdap), provides an example of a way this can be achieved. The idea of combining chlorproguanil with dapsone came from studies done in east Africa in the 1980s. These studies showed, both in vivo and in vitro, that chlorproguanil/dapsone had advantages over sulphadoxine/pyrimethamine. A public-private partnership was established subsequently to manage a development programme of a fixed ratio tablet of this drug combination. The partnership comprised GlaxoSmithKline (formerly SmithKline Beecham), the World Health Organization (WHO), and the UK's Department for International Development (DFID). All clinical, toxicological, and pharmaceutical chemistry studies are complete and the findings have been submitted for regulatory approval. The question now is how Lapdap might be used safely and appropriately if it receives regulatory approval. A public-health group has been formed by WHO (with funding from DFID and the Gates Foundation) to research into this issue. The Lapdap development team completed its objective of submitting Lapdap for drug registration within a period of 5 years and at a low cost. Experience with the development of Lapdap may provide a model for the introduction of other new drugs developed primarily for use in developing countries. PMID:12614733

Lang, Trudie; Greenwood, Brian

2003-03-01

263

Approaches to understanding the searching behavior of CrossFire users.  

PubMed

Due to the high costs of purchasing, supporting and training users of desktop chemical information systems, it is important to understand users' behavior in order that deficiencies in their search efficiency and effectiveness can be identified and addressed. CrossFire generates comprehensive log files that can be examined to determine the nature of search activity. At GSK (GlaxoSmithKline) a Log File Parser, CrossParse, has been developed in Visual Basic that enables analysis by individual user name, groups of users or the whole user population. Log files can be analyzed for occasions when specific structural features are built, specific types of search are done and how the results are manipulated. CrossParse produces output that can be saved and analyzed within Microsoft Excel. It also allows determination of numbers of active concurrent users on the CrossFire system. CrossParse has been used at GSK (ex-SmithKline Beecham sites) to examine the search behavior of medicinal and synthetic chemists. Additionally, it has been used by MIMAS (Manchester Information and Associated Services) to compare the search behavior of trained and untrained users in the higher education community and to identify any areas where improvements to training can be made. Use of CrossParse in both organizations has allowed identification of areas where users may have difficulties using CrossFire. This will provide valuable feedback to MDL Inc., the authors of the CrossFire application, and guide them in enhancing CrossFire. PMID:12376989

Cooke, Frank; Kopelev, Nikolai; Schofield, Helen; Boyce, Geraldine; Dunne, Sean

264

Heart failure therapy: drugs, genes or stem cells?  

PubMed

Professor Sian Harding talks to Caroline Telfer, Assistant Commissioning Editor. Professor Sian Harding obtained her PhD in Pharmacology from King's College, London (UK) in 1981. She became Professor of Cardiac Pharmacology at the National Heart and Lung Institute, a division of the Imperial College Faculty of Medicine, in 2002. Her work has been funded by the British Heart Foundation, the Wellcome Trust, the Medical Research Council, the Biochemical and Biophysical Research Council, the The National Centre for the Replacement, Refinement and Reduction of Animals in Research, Pfizer, GlaxoSmithKline and SmithKline Beecham. Harding is former president of the European Section of the International Society for Heart Research and has organized international cardiovascular science meetings for this society, as well as for the European Society of Cardiology. She is the principal investigator for the first UK gene therapy trial aimed at improving cardiac contractility, organized jointly at Harefield and Papworth Hospitals. Harding is a member of the Nuffield Council on Bioethics and the Medical Research Coucil Regenerative Medicine Research Committee, and Director of a recently awarded British Heart Foundation Cardiovascular Regenerative Medicine Centre. She has been elected Fellow of the American Heart Association, European Society of Cardiology, International Society for Heart Research, Society of Biology and British Society of Pharmacology. PMID:24020663

Harding, Sian

2013-09-01

265

BATH 2. VIEW FACING SOUTHEAST CAMP H.M. SMITH AND ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

BATH 2. VIEW FACING SOUTHEAST - CAMP H.M. SMITH AND NAVY PUBLIC WORKS CENTER MANANA TITLE VII (CAPEHART) HOUSING, M-SHAPED FOUR-BEDROOM DUPLEX TYPE 5, Birch Circle, Cedar Drive, Pearl City, Honolulu County, HI

266

Actor Jaden Smith Focuses on Earth Science in a New NASA PSA  

NASA Website

Jaden Smith, star of Columbia Pictures' movie "After Earth," is featured in a new NASA public service announcement that describes the contributions of the agency's Earth science program to environmental awareness ...

267

Superfund Record of Decision (EPA Region 4): Smith's Farm, Operable Unit 2, Brooks, KY.  

National Technical Information Service (NTIS)

This decision document presents the selected final remedial action for the Second Operable Unit of the Smith's Farm Site, Brooks, Bullitt County, Kentucky. The function of this remedy is to reduce the risk associated with exposure to the (1) contaminated,...

1993-01-01

268

Design of Smith Control Schemes for Time-Delay Systems Based on Plant Step Data.  

National Technical Information Service (NTIS)

It is demonstrated that approximation ideas conceived for the design of multivariable feedback systems based on approximate plant models carry over to the design of Smith control schemes in the presence of mismatch. The approaches are very similar in stru...

A. Chotai D. H. Owens A. Raya H. M. Wang

1983-01-01

269

Transmittal of Report of Investigation -- David Smith, Deputy Assistant Secretary, Fish, Wildlife and Parks.  

National Technical Information Service (NTIS)

This memorandum transmits the results of the Office of Inspector General(OIG) investigation into an allegation that David Smith, Deputy Assistant Secretary, Fish, Wildlife and Parks, inappropriately designated Houston as a port of entry under the Endanger...

2006-01-01

270

VIEW OF SMITH FORGING METAL SPECIMEN USING 3,000POUND DROP HAMMER ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

VIEW OF SMITH FORGING METAL SPECIMEN USING 3,000-POUND DROP HAMMER NO. 1, MAN TO RIGHT IS OPERATING HAMMER WHILE OTHER SHAPES SPECIMEN. - Cambria Iron Company, Blacksmith Shop, Lower Works, Johnstown, Cambria County, PA

271

Artrodese cervical anterior pela técnica de Smith-Robinson Anterior cervical fusion by the Smith-Robinson method Artrodesis cervical anterior por la técnica de Smith-Robinson ARTIGO ORIGINAL \\/ ORIGINAL ARTICLE  

Microsoft Academic Search

Objective: to retrospectively evaluate patients with degenerative disc disease of the cervical spine, submitted to an anterior cervical fusion by a technique by the Smith-Robinson without instrumentation. Methods: twenty one patients were retrospectively analyzed. Eleven female and 10 male patients, with a mean age of 42 years, with degenerative disease of the cervical spine, were operatively treated, from August 2005

Iberê Ribeiro; Jair Ortiz; Carlos Tucci Neto

272

Basic repository environmental assessment design basis: Deaf Smith County site  

SciTech Connect

This study examines the engineering factors and costs associated with the construction, operation, and decommissioning of a high-level nuclear waste repository in salt in the Palo Duro Basin in Deaf Smith County, Texas. The study assumes a repository capacity of 36,000 metric tons of heavy metal (MTHM) of unreprocessed spent fuel and 36,000 MTHM of commercial high-level reprocessing waste, along with 7,020 canisters of defense high-level reprocessing waste and associated quantities or remote- and contact-handled transuranic waste (TRU). With the exception of TRU, all the waste forms are placed in 300- to 1000-year-life carbon-steel waste packages in a collocated waste handling and packaging facility (WHPF), which is also described. The construction, operation, and decommissioning of the proposed repository is estimated to cost approximately $4.64 billion. Costs include those for the collocate WHPF, engineering, and contingency, but exclude waste form assembly and shipment to the site and waste package fabrication and shipment to the site. These costs reflect the relative average wage rates of the region, the relatively easy access to the site, and the relatively weak nature of the salt at this site. Construction would require an estimated 7 to 7.5 years. Engineering factors and costs are not strongly influenced by environmental considerations. 62 refs., 24 figs., 20 tabs.

Not Available

1988-03-01

273

Smith River Rancheria's Development of an Energy Organization Investigation  

SciTech Connect

Smith River Rancheria (SRR), for some time, has had a strong commitment to attaining energy selfsufficiency, to reduce overall energy costs and concurrently initiate economic development within the community. Early on it was recognized that the development of an energy organization was important and for this reason was made part of the SRR's strategic review not only for economic development but also the reduction of energy costs. Towards this end, SRR retained Werner G. Buehler of W.G. Buehler & Associates to investigate the many phases or steps required to establish such an energy organization and determine, if in fact, it could benefit the Tribe. The basic phases are delineated as: (1) Identify potential sources of wholesale power and transmission paths; (2) Evaluating the various forms of energy organizations; (3) Determining the benefits (and disadvantages) of each form of organization; (4) Gathering costs to organize and operate the selected form or energy organization; (5) Performing an economic analysis of forming and operating an energy organization; and (6) Develop an implementation plan.

W.G Buehler & Associates

2007-08-27

274

Autism spectrum features in Smith-Magenis syndrome.  

PubMed

Smith-Magenis syndrome (SMS; OMIM 182290) is a neurodevelopmental disorder characterized by a well-defined pattern of anomalies. The majority of cases are due to a common deletion in chromosome 17p11.2 that includes the RAI1 gene. In children with SMS, autistic-like behaviors and symptoms start to emerge around 18 months of age. This study included 26 individuals (15 females and 11 males), with a confirmed deletion (del 17p11.2). Parents/caregivers were asked to complete the Social Responsiveness Scale (SRS) and the Social Communication Questionnaire (SCQ) both current and lifetime versions. The results suggest that 90% of the sample had SRS scores consistent with autism spectrum disorders. Moreover, females showed more impairment in total T-scores (P?=?0.02), in the social cognition (P?=?0.01) and autistic mannerisms (P?=?0.002) subscales. The SCQ scores are consistent to show that a majority of individuals may meet criteria for autism spectrum disorders at some point in their lifetime. These results suggest that SMS needs to be considered in the differential diagnosis of autism spectrum disorders but also that therapeutic interventions for autism are likely to benefit individuals with SMS. The mechanisms by which the deletion of RAI1 and contiguous genes cause psychopathology remain unknown but they provide a solid starting point for further studies of gene-brain-behavior interactions in SMS and autism spectrum disorders. PMID:20981775

Laje, Gonzalo; Morse, Rebecca; Richter, William; Ball, Jonathan; Pao, Maryland; Smith, Ann C M

2010-11-15

275

Peroxisomal cholesterol biosynthesis and Smith-Lemli-Opitz syndrome  

SciTech Connect

Smith-Lemli-Opitz syndrome (SLOS), caused by 7-dehydrocholesterol-reductase (DHCR7) deficiency, shows variable severity independent of DHCR7 genotype. To test whether peroxisomes are involved in alternative cholesterol synthesis, we used [1-{sup 14}C]C24:0 for peroxisomal {beta}-oxidation to generate [1-{sup 14}C]acetyl-CoA as cholesterol precursor inside peroxisomes. The HMG-CoA reductase inhibitor lovastatin suppressed cholesterol synthesis from [2-{sup 14}C]acetate and [1-{sup 14}C]C8:0 but not from [1-{sup 14}C]C24:0, implicating a peroxisomal, lovastatin-resistant HMG-CoA reductase. In SLOS fibroblasts lacking DHCR7 activity, no cholesterol was formed from [1-{sup 14}C]C24:0-derived [1-{sup 14}C]acetyl-CoA, indicating that the alternative peroxisomal pathway also requires this enzyme. Our results implicate peroxisomes in cholesterol biosynthesis but provide no link to phenotypic variation in SLOS.

Weinhofer, Isabelle [Center for Brain Research, Medical University of Vienna, Vienna (Austria); Kunze, Markus [Center for Brain Research, Medical University of Vienna, Vienna (Austria); Stangl, Herbert [Department of Medical Chemistry, Medical University of Vienna, Vienna (Austria); Porter, Forbes D. [National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD (United States); Berger, Johannes [Center for Brain Research, Medical University of Vienna, Vienna (Austria)]. E-mail: johannes.berger@meduniwien.ac.at

2006-06-23

276

Pharmacological treatment of disruptive behavior in Smith-Magenis syndrome.  

PubMed

Smith-Magenis syndrome (SMS) is a complex genetic syndrome caused by an interstitial deletion of chromosome 17p11.2. Children and adults with SMS appear to have unique neurobehavioral problems that include: sleep disturbance, self-injurious and maladaptive behaviors, stereotypies, and sensory integration disorders. We gathered retrospective psychotropic use information from parents or other caregivers of 62 individuals with SMS who were asked about use of psychotropic medication from a list of commonly used psychiatric medications. For those drugs identified, respondents were asked to rate the experience with the particular medication using a likert-type scale. Drugs were grouped into seven main categories: (1) stimulants; (2) antidepressants; (3) antipsychotics; (4) sleep aides; (5) mood stabilizers; (6) alpha 2 agonists; and (7) benzodiazepines. Relative frequencies, means and standard deviations pertaining to age and medication effect were derived for each medication category. Six of the seven medication categories examined showed no meaningful deviations from the "no change" score. The benzodiazepine group showed a mild detrimental effect. There were no gender differences in efficacy. Use of psychotropic medication started early in life (mean age 5 years), particularly with sleep aides. Although no medication category was identified as efficacious in SMS, all the categories reported herein may be considered as an option for brief symptomatic relief. PMID:20981776

Laje, Gonzalo; Bernert, Rebecca; Morse, Rebecca; Pao, Maryland; Smith, Ann C M

2010-11-15

277

Parallel divide and conquer bio-sequence comparison based on smith-waterman algorithm  

Microsoft Academic Search

Tools for pair-wise bio-sequence alignment have for long played a central role in computation biology. Several algorithms\\u000a for bio-sequence alignment have been developed. The Smith-Waterman algorithm, based on dynamic programming, is considered\\u000a the most fundamental alignment algorithm in bioinformatics. However the existing parallel Smith-Waterman algorithm needs large\\u000a memory space, and this disadvantage limits the size of a sequence to be

Fa Zhang; Xiangzhen Qiao; Zhiyong Liu

2004-01-01

278

Qualitative and quantitative analysis in systematic dialectics: Marx vs. Hegel and Arthur vs. Smith  

Microsoft Academic Search

Whether capitalism is best studied using qualitative or quantitative methods is a standing issue. A key determinant in answering this is whether numerical measures can be meaningfully imposed on it epistemologically or even be said to constitute it ontologically. Reflecting on Smith’s and Arthur’s accounts of Hegel’s influence on Marx, it is concluded that both caveats are true for capitalism.

D. Damsma

2010-01-01

279

FROM THE BARRIO TO THE BUCOLIC: THE STUDENT TRANSFER EXPERIENCE FROM HSIS TO SMITH COLLEGE  

Microsoft Academic Search

The study reported in this article examined two Hispanic-serving institutions, Miami-Dade Community College and Santa Monica College, and the innovative transfer agreements they have with Smith College, a highly selective private women's college. Factors that influence the successful transfer of women students to Smith from these HSIs are highlighted. The article concludes with recommendations for how Hispanic-serving institutions, and community

Lisa Wolf-Wendel; Susan Twombly; Christopher Morphew; Joseph Sopcich

2004-01-01

280

Efficacy and Safety of Fluticasone Furoate/Vilanterol Compared With Fluticasone Propionate/Salmeterol Combination in Adult and Adolescent Patients With Persistent Asthma  

PubMed Central

Background: The combination of fluticasone furoate (FF), a novel inhaled corticosteroid (ICS), and vilanterol (VI), a long-acting ?2 agonist, is under development as a once-daily treatment of asthma and COPD. The aim of this study was to compare the efficacy of FF/VI with fluticasone propionate (FP)/salmeterol (SAL) in patients with persistent asthma uncontrolled on a medium dose of ICS. Methods: In a randomized, double-blind, double-dummy, parallel group study, 806 patients received FF/VI (100/25 ?g, n = 403) once daily in the evening delivered through ELLIPTA (GlaxoSmithKline) dry powder inhaler, or FP/SAL (250/50 ?g, n = 403) bid through DISKUS/ACCUHALER (GlaxoSmithKline). The primary efficacy measure was 0- to 24-h serial weighted mean (wm) FEV1 after 24 weeks of treatment. Results: Improvements from baseline in 0- to 24-h wmFEV1 were observed with both FF/VI (341 mL) and FP/SAL (377 mL); the adjusted mean treatment difference was not statistically significant (?37 mL; 95% CI, ?88 to 15, P = 0.162). There were no differences between 0- to 4-h serial wmFEV1, trough FEV1, and asthma control and quality-of-life questionnaire scores. There was no difference in reported exacerbations between treatments. Both treatments were well tolerated, with no clinically relevant effect on urinary cortisol excretion or vital signs and no treatment-related serious adverse events. Conclusions: The efficacy of once-daily FF/VI was similar to bid FP/SAL in improving lung function in patients with persistent asthma. No safety issues were identified. Trial registry: ClinicalTrials.gov; No.: NCT01147848; URL: www.clinicaltrials.gov

Bleecker, Eugene R.; Lotvall, Jan; O'Byrne, Paul M.; Bateman, Eric D.; Medley, Hilary; Ellsworth, Anna; Jacques, Loretta; Busse, William W.

2013-01-01

281

Draft environmental assessment: Deaf Smith County site, Texas. Nuclear Waste Policy Act (Section 112). [Contains Glossary  

SciTech Connect

In February 1983, the US Department of Energy identified a location in Deaf Smith County, Texas, as one of nine potentially acceptable sites for a mined geologic repository for spent nuclear fuel and high-level radioactive waste. The potentially acceptable site was subsequently narrowed to an area of 9 square miles. To determine their suitability, the Deaf Smith site and the eight other potentially acceptable sites have been evaluated in accordance with the DOE's General Guidelines for the Recommendation of Sites for Nuclear Waste Repositories. These evaluations are reported in this draft environmental assessment, which is being issued for public review and comment. The DOE findings and determinations that are based on these evaluations are preliminary and subject to public review and comment. A final EA will be prepared after considering the comments received. On the basis of the evaluations reported in this draft EA, the DOE has found that the Deaf Smith site is not disqualified under the guidelines. The site is in the Permian Basin, which is one of five distinct geohydrologic settings considered for the first repository. This setting contains one other potentially acceptable site - the Swisher site. Although the Swisher site appears to be suitable for site characterization, DOE has concluded that the Deaf Smith site is the preferred site. The DOE finds that the site is suitable for site characterization because the evidence does not support a conclusion that the site will not be able to meet each of the qualifying conditions specified in the guidelines. On the basis of these findings, the DOE is proposing to nominate the Deaf Smith site as one of five sites suitable for characterization. Having compared the Deaf Smith site with the other four sites proposed for nomination, the DOE has determined that the Deaf Smith site is one of the three preferred sites for recommendation to the President as candidates for characterization.

Not Available

1984-12-01

282

Geology, paleoclimatology and the evolution of the kidney: some explorations into the legacy of Homer Smith.  

PubMed

The aim of this review is to perform an overview of the relation between kidney development in different species and new developments in plate tectonics and paleoclimatology, which likely had a remarkable effect on evolution. The review follows the ideas of Homer Smith, but adds new data on the subjects which were unknown in Homer Smith's time. The structure and function of the kidney are a result of hundreds of millions of years of evolution, in which adaptations had to be made in response to environmental demands while maintaining the kidney's integrated function. The ideas of Homer Smith have greatly contributed to our understanding of this process, and continue to be of relevance both for researchers as well as physicians working in the field of kidney disease. PMID:22572704

Kooman, Jeroen P

2012-05-09

283

Maternal apo E genotype is a modifier of the Smith-Lemli-Opitz syndrome  

PubMed Central

Background: Smith-Lemli-Opitz syndrome (MIM 270400) is an autosomal recessive malformation and mental retardation syndrome that ranges in clinical severity from minimal dysmorphism and mild mental retardation to severe congenital anomalies and intrauterine death. Smith-Lemli-Opitz syndrome is caused by mutations in the ?7 sterol-reductase gene (DHCR7; EC 1.3.1.21), which impair endogenous cholesterol biosynthesis and make the growing embryo dependent on exogenous (maternal) sources of cholesterol. We have investigated whether apolipoprotein E, a major component of the cholesterol transport system in human beings, is a modifier of the clinical severity of Smith-Lemli-Opitz syndrome. Method: Common apo E, DHCR7, and LDLR genotypes were determined in 137 biochemically characterised patients with Smith-Lemli-Opitz syndrome and 59 of their parents. Results: There was a significant correlation between patients' clinical severity scores and maternal apo E genotypes (p = 0.028) but not between severity scores and patients' or paternal apo E genotypes. In line with their effects on serum cholesterol levels, the maternal apo ?2 genotypes were associated with a severe Smith-Lemli-Opitz syndrome phenotype, whereas apo E genotypes without the ?2 allele were associated with a milder phenotype. The correlation of maternal apo E genotype with disease severity persisted after stratification for DHCR7 genotype. There was no association of Smith-Lemli-Opitz syndrome severity with LDLR gene variation. Conclusions: These results suggest that the efficiency of cholesterol transport from the mother to the embryo is affected by the maternal apo E genotype and extend the role of apo E and its disease associations to modulation of embryonic development and malformations.

Witsch-Baumgartne..., M; Gruber, M; Kraft, H; Rossi, M; Clayton, P; Giros, M; Haas, D; Kelley, R; Krajewska-Walasek, M; Utermann, G

2004-01-01

284

Automatic flatness control strategy with a Smith predictor for steel strip rolling  

NASA Astrophysics Data System (ADS)

The simplified transfer function diagram block for a automatic flatness control (AFC) system of strip steel rolling process was investigated. For the problem of automatic flatness control (AFC) in cold tandem mills this paper proposes control techniques based on Smith predictor to compensate for the numerous delays present in the mill. After a Smith predictor was used to the AFC system, the control laws were deduced for both proportional and integral regulators. Control algorithms are tested in simulation considering a tandem mill with four stands as a benchmark, and results are shown to demonstrate the performance of the proposed schemes.

Zhang, Ruicheng; Zheng, Xin

2011-10-01

285

Growth retarding effects of paclobutrazol and RSW 0411 on Granny Smith and Fuji apple trees  

Microsoft Academic Search

The growth retardants paclobutrazol (?-[(4-chlorophenyl)methyl]-?-(1,1-dimethylethyl)-1H-1,2,4-triazole-1-ethanol) and RSW\\u000a 0411 (?-(cyclohexyl methylene)-?-(1,1-dimethylethyl)-1H-1,2,4-triazole-1-ethanol) were tested on two-year-old trees of Granny\\u000a Smith and Fuji apple. RSW 0411 at 100 mg\\/L did not cause any growth reduction in Granny Smith, while 500 and 1000 mg\\/L significantly\\u000a reduced growth below that of the control between 27 and 40 days after application. Paclobutrazol at 100 mg\\/L had

D. E. Irving; J. C. Pallesen

1989-01-01

286

Reduce the start current of Smith-Purcell backward wave oscillator by sidewall grating  

SciTech Connect

A sidewall grating for the Smith-Purcell device is proposed to enhance the coupling of the optical mode with the electron beam and, consequently, relax the stringent requirements to the electron beam. With the help of three-dimensional particle-in-cell simulations, it has been shown that, comparing with the general grating, the usage of a sidewall grating improves the growth rate and dramatically shortens the time for the device to reach saturation. It is also found that the sidewall grating holds the potential to reduce the start current for the operation of a Smith-Purcell backward wave oscillator.

Li, D.; Imasaki, K.; Gao, X.; Yang, Z.; Park, Gun-Sik [Institute for Laser Technology, 2-6 Yamada-oka, Suita, Osaka 565-0871 (Japan); Institute of High-Energy Electronics, University of Electronic Science and Technology of China, Chengdu 610054 (China); School of Physics and Astronomy, Seoul National University, Seoul 151-747 (Korea, Republic of)

2007-11-26

287

Design of a grating for studying Smith-Purcell radiation and electron acceleration  

SciTech Connect

We describe work on the design fo a diffracton grating which we intend to use for studying the production of Smith-Purcell radiation and the acceleration of electrons. We have developed computer codes based on the solution of the appropriate Maxwell's equations. A specific grating profile is given which is feasible to construct and which supports enhanced surface accelerating modes. We examine the possibility of using the Smith-Purcell effect to make a beam position monitor. {copyright} 1989 American Institute of Physics

Fernow, R.C. (Brookhaven National Laboratory, Upton, NY 11973 (US))

1989-10-15

288

Improve growth rate of Smith-Purcell free-electron laser by Bragg reflector  

SciTech Connect

Grating with Bragg reflectors for the Smith-Purcell free-electron laser is proposed to improve the reflection coefficient, resulting in enhancing the interaction of the surface wave with the electron beam and, consequently, relax the requirements to the electron beam. With the help of particle-in-cell simulations, it has been shown that the usage of Bragg reflectors may improve the growth rate, shorten the time for the device to reach saturation, and lower the start current for the operation of a Smith-Purcell free-electron laser.

Li, D.; Imasaki, K. [Institute for Laser Technology, Suita, Osaka 565-0871 (Japan); Yang, Z. [Institute of High Energy Electronics, University of Electronic Science and Technology of China, Chengdu 610054 (China); Tsunawaki, Y. [Department of Electronics, Information and Communication Engineering, Osaka Sangyo University, Osaka 574-8530 (Japan); Asakawa, M. R. [Department of Pure and Applied Physics, Faculty of Engineering Science, Kansai University, Osaka 64-8680 (Japan); Hangyo, M. [Institute of Laser Engineering, Osaka University, Suita, Osaka 565-0871 (Japan); Miyamoto, S. [Laboratory of Advanced Science and Technology for Industry, University of Hyogo, Ako, Hyogo 678-1205 (Japan)

2011-05-23

289

Síndrome de Smith-Magenis: comunicación de un caso y revisión de la bibliografía Smith-Magenis syndrome: case report and review  

Microsoft Academic Search

SUMMARY Smith-Magenis syndrome (SMS) is characterized by distinctive facial features that progress with age, developmental delay, cognitive impairment, and behavioral abnormalities associ- ated with molecular anomaly in 17p11.2. Treatment includes: early childhood intervention programs, special education, vo- cational training later in life, and speech\\/language, physical, and occupational, behavioral, and sensory integration thera- pies. We report a 14-year-old girl with mental

Rubén Bronberg; María Ziembar; Mónica Drut; Ernesto Goldschmidt

290

THE LARVAL STAGES OF THE DEEP SEA RED CRAB, GBRYON QUINQUEDENS SMITH, REARED UNDER LABORATORY CONDITIONS (DECAPODA: BRACHYRHYNCHA)  

Microsoft Academic Search

A prezoeal stage, four zoeal stages, and one megalopa stage WE're obtained from eggs of Geryon quinquedens Smith hatched in the laboratory. Each zoeal stage and the megalopa are discussed and illustrated. The commercial potential and abundance of the deep sea red crab, Geryon quinquedens Smith, are discussed by Schroeder (1959), McRae (1961), and Holmsen (1968). The red crab is

HERBERT C. PERKINS

291

Jeremy Bentham and Adam Smith on the usury laws: a ‘Smithian’ reply to Bentham and a new problem  

Microsoft Academic Search

Adam Smith justified the contemporary usury laws and was severely criticised by Bentham and most modern writers with the important exception of J.M. Keynes. We argue that pace Bentham, Smith did not intend to preclude loan financing of all ‘risky’ ventures and give a ‘monopoly’ to safe investments and did not neglect the potential emergence of black credit markets. Yet

Samuel Hollander

1999-01-01

292

Business Ethics and the Origins of Contemporary Capitalism: Economics and Ethics in the Work of Adam Smith and Herbert Spencer  

Microsoft Academic Search

Both Adam Smith and Herbert spencer, albeit in quite different ways, have been enormously influential in what we today take to be philosophies of modern capitalism. Surprisingly it is Spencer, not Smith, who is the individualist, perhaps an egoist, and supports a \\

Patricia H. Werhane

2000-01-01

293

Dinâmica da alimentação natural de Callinectes danae Smith (Decapoda, Portunidae) na Lagoa da Conceição, Florianôpolis, Santa Catarina, Brasil  

Microsoft Academic Search

FEEDING NATURAL DYNAMICS OF Callinectes danae SMITH (DECAPODA, PORTUNIDAE) FROM LAGOA DA CONCEIÇÃO, FLORIANÓPOLIS, SANTA CATARINA, BRAZIL. From March\\/91 to February\\/92 monthly collection surveys were carried out to obtain basic information about the dynamics of feeding and trophic spectrum of C. danae Smith, 1869. A total of 456 males and 527 females were caught. The diet of the species was

Joaquim Olinto Branco; José Roberto Verani

1997-01-01

294

78 FR 11059 - Examination Guidelines for Implementing the First Inventor To File Provisions of the Leahy-Smith...  

Federal Register 2010, 2011, 2012, 2013

...for Implementing the First Inventor To File Provisions of the Leahy-Smith America...guidelines concerning the first inventor to file provisions of the Leahy-Smith America...invent'' system to a ``first inventor to file'' system, treats patents and...

2013-02-14

295

78 FR 16182 - Changes To Implement the First Inventor To File Provisions of the Leahy-Smith America Invents Act...  

Federal Register 2010, 2011, 2012, 2013

...Changes To Implement the First Inventor To File Provisions of the Leahy-Smith America...the changes in the first inventor to file provisions of the Leahy-Smith America Invents Act (AIA) (First Inventor to File Final Rule). Due to a technical...

2013-03-14

296

77 FR 43759 - Examination Guidelines for Implementing the First-Inventor-to-File Provisions of the Leahy-Smith...  

Federal Register 2010, 2011, 2012, 2013

...Implementing the First-Inventor-to- File Provisions of the Leahy-Smith America...concerning the first-inventor-to-file (FITF) provisions of the Leahy-Smith...invent'' system to a ``first inventor to file'' system, treats United States...

2012-07-26

297

Sir James Edward Smith (1759-1828) MD FRS, botanist, co-founder of the Linnean Society of London.  

PubMed

James Edward Smith's interest in botany led him to enter medicine at Edinburgh in 1781. Smith was continuing his medical studies in London when Sir Joseph Banks (1743-1820) suggested to him that he should purchase the collection of the famous Swedish naturalist Carl Linnaeus that had just been offered to Banks. Smith bought the Linnean Collection and Library in 1784. In 1786 he was awarded the degree of Doctor of Medicine from Leiden. In 1788 Smith, with two associates, founded the Linnean Society of London and became President for life. Smith turned from medicine to natural history as a lecturer and writer. During his lifetime he produced numerous botanical works of high value, including The English Flora (1824-28), and he did much to popularize botany. PMID:19401517

Hawgood, Barbara J

2009-05-01

298

VARIATIONS ON A THEME: THE THREE DIRECTORS OF THE FIRST FIFTY YEARS OF THE J.L.B. SMITH INSTITUTE OF ICHTHYOLOGY  

Microsoft Academic Search

The author, having known the first three Directors, Professors J.L.B. Smith, M.M. Smith and M.N. Bruton personally, was asked for a account of his recollections and impressions. This account is therefore anecdotal rather than historical. He first knew Professor J.L.B. Smith when an undergraduate, at Rhodes University 194–1948. though he was never Professor Smith's student. In 1972 during Professor M.M.

P. B. N. Jackson

1996-01-01

299

Smith College School for Social Work and Combat?Related Trauma: Allegiance, Scholarship, and Commitment  

Microsoft Academic Search

The Smith College School for Social Work (SCSSW) was founded for the purpose of treating soldiers returning from World War I who suffered from shell shock, conditions that are now described as combat?related trauma. As history evolved, America found itself embroiled in World War II, the Korean War, the Vietnam War, and contemporary conflicts in Iraq and Afghanistan. With each

Jamie L. Loveland

2009-01-01

300

American Scholars: Ralph Waldo Emerson, Joseph Smith, John Brown, and the Springs of Intellectual Schism  

Microsoft Academic Search

The essay examines Ralph Waldo Emerson, Joseph Smith, and John Brown as shapers and representatives of America's common, though riven, culture of intellectual life–charismatic thinkers and actors who spoke to their society's need for general explanatory ideas in idioms that continue to bespeak our nation's deepest commonalities and deepest fractures.

Evan Carton

2012-01-01

301

"Comments on Coulter and Smith": Narrative Researchers as Witnesses of Injustice and Agents of Social Change?  

ERIC Educational Resources Information Center

In commenting on Coulter and Smith (2009), the author explores issues related to the place of the political in education research and in literature, but especially in forms of narrative research that possess both scientific and literary dimensions. More specifically, the author examines four sets of issues related to the researching and writing of…

Barone, Tom

2009-01-01

302

Problem Behaviors Associated with Deletion Prader-Willi, Smith-Magenis, and Cri Du Chat Syndromes.  

ERIC Educational Resources Information Center

Problem behaviors of 38 individuals with Cri-du-Chat syndrome, 55 individuals with Prader Willi syndrome, and 21 individuals with Smith-Magenis syndrome were investigated. All three disorders were Associated with greater ratings of problem behaviors (besides eating abnormalities and sleep abnormalities) than comparison groups. (Author/CR)

Clarke, David J.; Boer, Harm

1998-01-01

303

Development and Behaviour in Marshall-Smith Syndrome: An Exploratory Study of Cognition, Phenotype and Autism  

ERIC Educational Resources Information Center

|Background: Marshall-Smith syndrome (MSS) is an infrequently described entity characterised by failure to thrive, developmental delay, abnormal bone maturation and a characteristic face. In studying the physical features of a group of patients, we noticed unusual behavioural traits. This urged us to study cognition, behavioural phenotype and…

van Balkom, I. D. C.; Shaw, A.; Vuijk, P. J.; Franssens, M.; Hoek, H. W.; Hennekam, R. C. M.

2011-01-01

304

Prevalence, Phenomenology, Aetiology and Predictors of Challenging Behaviour in Smith-Magenis Syndrome  

ERIC Educational Resources Information Center

Background: The prevalence, phenomenology aetiology and correlates of four forms of challenging behaviour in 32 children and adults with Smith-Magenis syndrome (SMS) were investigated. Methods: Cognitive assessments, questionnaires and semi-structured interviews were used to gather data on intellectual disability, verbal and physical aggression,…

Sloneem, J.; Oliver, C.; Udwin, O.; Woodcock, K. A.

2011-01-01

305

Energy Conservation Study on Smith Frozen Foods Processing Plant, Weston, Oregon.  

National Technical Information Service (NTIS)

A comprehensive energy study was performed at Smith Frozen Foods in Weston, Oregon, in the fall of 1984. The plant processes corn, peas, lima beans and carrots. The products are inspected, prepared and graded before being sent through freeze tunnels. The ...

1985-01-01

306

A Study of the Settlement Characteristics of the Soil Deposits at Kingsford-Smith Airport.  

National Technical Information Service (NTIS)

The paper describes the geotechnical studies carried out to establish the origin and rate of settlement of the soil deposits at Kingsford-Smith Airport, Mascot, N.S.W. Settlements were predominantly due to compression of a highly compressible silt-clay of...

I. K. Lee E. H. Davis B. Rodway R. Mallam

1969-01-01

307

"Employment Division v. Smith" Revisited: The Constriction of Free Exercise Rights under the United States Constitution.  

ERIC Educational Resources Information Center

|The Supreme Court decision in "Smith II" found two Native Americans, discharged from their jobs for using peyote as part of the sacramental service in their Native American Church, ineligible for unemployment compensation benefits. Examines how the decision has had an immediate and profound effect on judicial interpretation of free exercise…

Mawdsley, Ralph D.

1992-01-01

308

Colony structure and reproduction in the thelytokous parthenogenetic ant Platythyrea punctata (F. Smith) (Hymenoptera, Formicidae)  

Microsoft Academic Search

Summary: An important evolutionary characteristic of the formicine subfamily Ponerinae is the occurrence of various alternative reproductive tactics within single species. In Platythyrea punctata Smith, 1858, queens, gamergates and parthenogenetic workers co-occur in the same species. Morphological queens, both alate and dealate, were present in only 29 percent of the colonies collected in Florida, but absent from colonies collected in

K. Schilder; J. Heinze; B. Hölldobler

1999-01-01

309

“Seeing is Believingâ€?: Adam Smith and the Systemic Violence of Money  

Microsoft Academic Search

Advertising executives have long known that the appearance of products creates desire for those products. Political theorists, and economists, have also explored the relationship between visual events and our political desires. Adam Smith’s account of our social world relies on money, of course, but, just as consistently, it relies on our visual response to suffering and joy. Smith, for example,

Char Miller

310

Headed in the Right Direction: A Commentary on Yoshida and Smith  

ERIC Educational Resources Information Center

Yoshida and Smith (this issue) provide one of the first attempts to overcome the most serious impediment to the use of head-mounted eye trackers with infants: Except in rare cases they are not light enough to be worn on an infant's head, or the infant does not tolerate looking through a half-silvered mirror that is hanging on a rigid stalk…

Aslin, Richard N.

2008-01-01

311

Prevalence, Phenomenology, Aetiology and Predictors of Challenging Behaviour in Smith-Magenis Syndrome  

ERIC Educational Resources Information Center

|Background: The prevalence, phenomenology aetiology and correlates of four forms of challenging behaviour in 32 children and adults with Smith-Magenis syndrome (SMS) were investigated. Methods: Cognitive assessments, questionnaires and semi-structured interviews were used to gather data on intellectual disability, verbal and physical aggression,…

Sloneem, J.; Oliver, C.; Udwin, O.; Woodcock, K. A.

2011-01-01

312

Analysis of the Sensory Profile in Children with Smith-Magenis Syndrome  

ERIC Educational Resources Information Center

|This study systematically assessed sensory processing in 34 children, aged 3-14 years, with Smith-Magenis syndrome (SMS) using the Sensory Profile Caregiver Questionnaire. Scores for the SMS cohort were significantly different from scores of the national sample of children with and without disabilities in all Sensory Profile categories and…

Hildenbrand, Hanna L.; Smith, Ann C. M.

2012-01-01

313

Habitat Use by Juvenile Salmonids in the Smith River Estuary, California  

Microsoft Academic Search

Estuaries are highly productive areas that serve as important nursery habitat for many species of fish. Estuaries provide juvenile salmonids Oncorhynchus spp. with foraging habitats, refuge from predators, and areas in which smoltification and orientation for return migrations can occur. Our primary goal was to describe how juvenile salmonids use the Smith River estuary in northern California, a system that

Rebecca M. Quiñones; Timothy J. Mulligan

2005-01-01

314

2. Photocopied October 1976, from b.f smithIllistrations of the Croton ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. Photocopied October 1976, from b.f smithIllistrations of the Croton Aqueduct, New York, Wiley and Putnam, 1843. TITLE PAGE. SHOWS N.Y.C. FOUNTAIN MADE POSSIBLE BY THE AQUEDUCT. - Old Croton Aqueduct, New York, New York County, NY

315

A Case Study of Early Development in Smith-Magenis Syndrome  

ERIC Educational Resources Information Center

The aim of this article is to provide an in-depth description of early development in a young child with Smith-Magenis syndrome (SMS). SMS is a multisystem, neurodevelopmental genetic disorder associated with mental retardation that predisposes individuals to a distinct pattern of maladaptive behaviors and other neuropsychological impairments.…

Fidler, Deborah J.; Philofsky, Amy D.; Hepburn, Susan L.

2006-01-01

316

Analysis of the Sensory Profile in Children with Smith-Magenis Syndrome  

ERIC Educational Resources Information Center

This study systematically assessed sensory processing in 34 children, aged 3-14 years, with Smith-Magenis syndrome (SMS) using the Sensory Profile Caregiver Questionnaire. Scores for the SMS cohort were significantly different from scores of the national sample of children with and without disabilities in all Sensory Profile categories and…

Hildenbrand, Hanna L.; Smith, Ann C. M.

2012-01-01

317

Closed-Loop Pressure Control Based on Smith Predictor for Gas Distribution Network  

Microsoft Academic Search

The closed loop control problem of gas distribution network is investigated in this paper. This system involves two control loops where the secondary part of the process (the inner loop) has a negligible delay while the primary loop (the outer loop) has a significant and time variant delay. The use of Smith Predictor in the outer loop of cascade control

A. Talasaz; A. N. Shooshtari

2007-01-01

318

Headed in the Right Direction: A Commentary on Yoshida and Smith  

ERIC Educational Resources Information Center

|Yoshida and Smith (this issue) provide one of the first attempts to overcome the most serious impediment to the use of head-mounted eye trackers with infants: Except in rare cases they are not light enough to be worn on an infant's head, or the infant does not tolerate looking through a half-silvered mirror that is hanging on a rigid stalk…

Aslin, Richard N.

2008-01-01

319

A Case Study of Early Development in Smith-Magenis Syndrome  

ERIC Educational Resources Information Center

|The aim of this article is to provide an in-depth description of early development in a young child with Smith-Magenis syndrome (SMS). SMS is a multisystem, neurodevelopmental genetic disorder associated with mental retardation that predisposes individuals to a distinct pattern of maladaptive behaviors and other neuropsychological impairments.…

Fidler, Deborah J.; Philofsky, Amy D.; Hepburn, Susan L.

2006-01-01

320

Superradiant terahertz Smith-Purcell radiation from surface plasmon excited by counterstreaming electron beams  

Microsoft Academic Search

The authors show that evanescent tunneling transmission of effective surface plasmon polaritons between two counterstreaming electron beams noticeably increases Smith-Purcell radiation (SPR) intensity by about two orders of magnitude as well as lower its transition threshold from a spontaneous emission to a stimulated one. An emission mechanism of the superradiant SPR is theoretically analyzed by the dielectric conversion of the

Young-Min Shin; Jin-Kyu So; Kyu-Ha Jang; Jong-Hyo Won; Anurag Srivastava; Gun-Sik Park

2007-01-01

321

Latent Theoretical Convergence upon a Pluralist Conception of Economic Action: Adam Smith and Max Weber  

Microsoft Academic Search

This paper engages in exploring certain latent theoretical convergences between the works of Adam Smith and Max Weber. The fact that these two have been major protagonists in the establishment and development of political economy and sociology respectively gives a rationale to such an endeavor. Another rationale is provided by the paucity of attempts at exploring the theoretical relations between

Milan Z. Zafirovski

2000-01-01

322

Re-imagining America: Jeff Smith, Herman Melville, and national dreamscapes  

Microsoft Academic Search

A recurring gag in Jeff Smith's acclaimed graphic novel series Bone (1991–2004) is that Moby-Dick (1851) is a snoozer. But, as we argue, Herman Melville's masterpiece puts other characters to sleep not because it is dull but because its most ardent advocate – protagonist Fone Bone himself – is a New Critic bent on divorcing the novel from the context

Jennifer A. Hughes; Philip Nel

2012-01-01

323

Collection Development Statement for the Reference Collection of the Ethel K. Smith Library, Wingate University.  

ERIC Educational Resources Information Center

This document is a statement of guidelines for the collection of reference materials at the Ethel K. Smith Library in Wingate University (North Carolina). The library's mission statement is given at the outset. Then parameters are established for the reference collection's scope and size, including subject-area and media priorities. The statement…

Wetherbee, James M.

324

Inhibitory effects of Cyrtomium fortunei J. Smith root extract on melanogenesis  

PubMed Central

Background: Recently, a great deal of attention has been directed toward the use of crude extracts from natural products for cosmetic applications. Thus, we performed a series of experiments to investigate skin depigmenting properties of a crude extract that was derived from a traditional Korean medicinal plant. Materials and Methods: In this study, the depigmentational potency of Cyrtomium fortunei J. Smith was investigated. The inhibitory effects of the root of Cyrtomium fortunei J. Smith extract on melanin production were evaluated by assessing its tyrosinase inhibitory effects, melanin production-inhibitory properties in melan-a cells and depigmenting ability in brown guinea pig skin. Results: The methanolic extract of the root of Cyrtomium fortunei J. Smith appeared to inhibit tyrosinase activity and melanin production in melan-a cells. In addition, this extract exhibited depigmenting ability on Ultra violet-induced hyper pigmentation in brown guinea pig skin. Conclusion: These results suggested that root of Cyrtomium fortunei J. Smith might prove useful in treating skin hyperpigmentation associated with excess sun-exposure.

Choi, Sang Yoon

2013-01-01

325

Fractional-order boundary control of fractional wave equation with delayed boundary measurement using Smith predictor  

Microsoft Academic Search

In this paper, we consider boundary control of a fractional order wave equation. Both integer order and fractional order boundary control laws are investigated. When delayed boundary measurements are used for boundary control, the Smith predictor is applied. Through extensive hybrid symbolic and numerical simulation, combined with parameter optimization, for the first time, we confirmed that (1) small time delay

Jinsong Liang; M. Q.-H. Meng; YangQuan Chen; Rees Fullmer

2004-01-01

326

Antimicrobial activity of aerial parts of Drosera peltata Smith on oral bacteria  

Microsoft Academic Search

The antimicrobial activity of extracts of aerial parts of Drosera peltata Smith against oral bacteria was investigated using agar diffusion and dilution micromethods. The chloroformic extract, active against all the bacteria tested, showed the most significant antimicrobial properties. Plumbagin, isolated from the extract, is the active principle. Results obtained suggest that Drosera peltata extract could be used in the treatment

Nicole Didry; Luc Dubreuil; Francis Trotin; Madeleine Pinkas

1998-01-01

327

Adaptive and Maladaptive Behavior in Children with Smith-Magenis Syndrome  

ERIC Educational Resources Information Center

|Children with Smith-Magenis Syndrome (SMS) exhibit deficits in adaptive behavior but systematic studies using objective measures are lacking. This descriptive study assessed adaptive functioning in 19 children with SMS using the Vineland Adaptive Behavior Scales (VABS). Maladaptive behavior was examined through parent questionnaires and the…

Martin, Staci C.; Wolters, Pamela L.; Smith, Ann C. M.

2006-01-01

328

A new Smith predictor for controlling a process with an integrator and long dead-time  

Microsoft Academic Search

A new Smith predictor for control of a process with an integrator and long dead-time is proposed in this note. The controller decouples the setpoint response from the load response. This simplifies both design and tuning. Simulation results obtained by controlling a typical process show that the new controller has superior performance compared to previous algorithms

K. J. Astrom; C. C. Hang; B. C. Lim

1994-01-01

329

Ecology, host specificity and impact of Atomacera petroa Smith (Hymenoptera: Argidae) on Miconia calvescens DC (Melastomataceae)  

Microsoft Academic Search

Miconia calvescens DC (Melastomataceae) is an invasive tree considered to be the greatest threat to natural ecosystems of Hawaii and other Pacific islands. The potential of the sawfly Atomacera petroa Smith (Hymenoptera: Argidae) as a biological control agent of M. calvescens was evaluated in field and laboratory studies in its native range in Brazil. At two field sites, 31.1% and

Francisco R. Badenes-Perez; M. Tracy Johnson

2007-01-01

330

"Comments on Coulter and Smith": The Issue of Authorial Surplus in Narrative Research  

ERIC Educational Resources Information Center

|Advocates of narrative research often contend that it is superior to nonnarrative research, both qualitative and quantitative, because they believe it is better able to represent multiple perspectives and foster multiple interpretations. The author of this comment article on Coulter and Smith (2009) draws on literary theory and an analysis of the…

Smith, Michael W.

2009-01-01

331

Gain characteristics of free-electron lasers using the Smith-Purcell effect  

SciTech Connect

Coupled-mode approach and electron Bloch equations are combined to calculate the gain of free-electron lasers using the Smith-Purcell effect in the gain quantum model. The possibility of increasing gain by changing the spatial frequency of the grating is studied.

Zhang Dake

1986-02-01

332

Enhancement of Smith-Purcell radiation from a grating with surface-plasmon excitation  

SciTech Connect

The Smith-Purcell radiation from a charge moving across a penetrable grating is studied. We account for the finite permittivity and the absorption effect of the grating and find that enhancement of the radiation will occur near particular angles of observation at which the phase-matching condition for the excitation of the surface-plasmon mode is satisfied.

Chuang, S.L.; Kong, J.A.

1984-06-01

333

Cold-induced accumulation of 1-aminocyclopropane 1-carboxylate oxidase protein in Granny Smith apples  

Microsoft Academic Search

Preclimacteric Granny Smith apple (Malus domestica Borkh.) fruits exhibited a sharp increase in ethylene production after 5 days in the cold (4 °C), while in the absence of chilling (17 °C) ethylene production started to increase only at 35 days. Antibodies raised against a recombinant tomato 1-aminocyclopropane 1-carboxylate oxidase — the enzyme catalyzing the conversion of ACC into C2H4 —

J. M. Lelièvre; L. Tichit; L. Fillion; C. Larrigaudière; M. Vendrell; J. C. Pech

1995-01-01

334

IN A WORD OR TWO, PLACED IN THE MIDDLE: THE INVISIBLE HAND IN SMITH'S TOMES  

Microsoft Academic Search

We explore the conjecture, first hinted at by Peter Minowitz, that Smith deliberately placed his central idea, as represented by the phrase led by an invisible hand, at the physical centre of his masterworks. The four most significant points developed are as follows: (1) The physical evidence: the expression led by an invisible hand occurs pretty much dead centre of

Daniel B. Klein; Brandon Lucas

2011-01-01

335

Design of a Grating for Studying Smith-Purcell Radiation and Electron Acceleration.  

National Technical Information Service (NTIS)

We describe work on the design of a diffraction grating which we intend to use for studying the production of Smith-Purcell radiation and the acceleration of electrons. We have developed computer codes based on the solution of the appropriate Maxwell's eq...

R. C. Fernow

1989-01-01

336

The logic of economic discourse: beyond Adam Smith and Karl Marx  

Microsoft Academic Search

Economic discourse has two interesting properties. It tends to be all-encompassing and it tends to shape the reality which it sets out to describe. Systems of economic theory can become very powerful and those based on ideas from Adam Smith and Karl Marx are good examples. Each of these has produced serious problems which are difficult to cope with because

Leslie Armour

1997-01-01

337

HALL. VIEW FACING NORTH CAMP H.M. SMITH AND NAVY ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

HALL. VIEW FACING NORTH - CAMP H.M. SMITH AND NAVY PUBLIC WORKS CENTER MANANA TITLE VII (CAPEHART) HOUSING, U-SHAPED THREE-BEDROOM DUPLEX TYPE 4, Acacia Road, Birch Circle, Cedar Drive and Elm Drive, Pearl City, Honolulu County, HI

338

Does “Bettering Our Condition” Really Make Us Better Off? Adam Smith on Progress and Happiness  

Microsoft Academic Search

dam Smith is almost certainly history's most famous advocate of commercial society, but he frankly admits that the relentless pursuit of wealth is a major obstacle to tranquility and content- ment and hence that, at first glance, the higher living standards that people \\

DENNIS C. RASMUSSEN

2006-01-01

339

Ideology and Reform in Teacher Education in England: Some Reflections on Cochran-Smith and Fries.  

ERIC Educational Resources Information Center

|Presents an international perspective on Cochran-Smith and Fries' recent analysis of the ways that two competing ideologies (deregulation and professionalization) are being employed in the United States to support teacher education reform, noting important differences between the United States and England in how these ideologies have been…

Furlong, John

2002-01-01

340

Population Genetics of the Western Bean Cutworm Striacosta albicosta Smith (Lepidoptera: Noctuidae) Across the United States  

Technology Transfer Automated Retrieval System (TEKTRAN)

The western bean cutworm, Striacosta albicosta (Smith), is a secondary pest of maize (Zea mays L.) and dry beans (Phaseolus vulgaris L.) in the western United States. Recently, this insect has undergone a major territory expansion into the eastern US and has become a pest throughout much of the Corn...

341

Back to Beginnings: Credentialism, Productivity, and Adam Smith's Division of Labour.  

ERIC Educational Resources Information Center

|The foundation of factional pressures for upgrading educational credentials in the labor market is examined through a review of human capital and screening theories. The writings of Adam Smith are referenced to show that the claims of the beneficial effects of educational upgrading have been questioned for 200 years. (Author/MLW)|

Davis, Denis J.

1981-01-01

342

Comparing Adam Smith's Wealth of Nations to James Madison's Federalist #10.  

ERIC Educational Resources Information Center

|Presents a lesson which calls upon students to compare Adam Smith's WEALTH OF NATIONS to James Madison's FEDERALIST #10 to see how the ancient concept of individual rights and liberties was used to describe both economic and governmental systems. Presents questions to provide the basis for comparison. (GEA)|

Mundell, Jean

1987-01-01

343

Effects of low preharvest temperature on scald susceptibility and biochemical changes in `Granny Smith' apple peel  

Microsoft Academic Search

An over-tree mist system provided evaporative cooling of the `Granny Smith' apple fruit. The temperatures of fruit under mist, control (without mist) and air were recorded from 1 September until harvest. Fruit were harvested when 30, 60, 80, 100, 120 and 160h at less than 10°C had been recorded. Fruit maturity indices (flesh firmness, soluble solids, titratable acidity, starch index,

T. Thomai; E. Sfakiotakis; Gr. Diamantidis; M. Vasilakakis

1998-01-01

344

CRESCIMENTO DE Callinectes danae SMITH (DECAPODA, PORTUNIDAE) DA LAGOA DA CONCEIÇÃO, FLORIANÓPOLIS, SANTA CATARINA, BRAZIL  

Microsoft Academic Search

THE GROWTH OF CALLINECTES DANAE SMITH (DECAPODA, PORTUNIDAE) FROM THE CONCEIÇÃO LAGOON, FLORIANÓPOLIS, SANTA CATARINA STATE, BRAZIL. Studies on the growth of the blue crab C. danae were carried out by the analysis of size-frequency distributions, and the growth curves were determined for both sexes through Bertalanffy equation. 613 males and 511 females were obtained from 10 collecting sites of

Joaquim Olinto Branco; Setuko Masunari

345

FECUNDIDADE EM Callinectes danae SMITH (DECAPODA, PORTUNIDAE) DA LAGOA DA CONCEIÇÃO, FLORIANÓPOLIS, SANTA CATARINA, BRASIL  

Microsoft Academic Search

FECUNDITY OF Callinectes danae SMITH (DECAPODA, PORTUNIDAE) IN LAGOA DA CONCEIÇÃO, SANTA CATARINA, BRAZIL. The estimate for the average fecundity for the C. dance population of Lagoa da Conceição (Florianópolis, Santa Catarina) was of 598.885 eggs by female. The average number of eggs and the weight of the mass of eggs, in general, increase with the female size. The variation

Joaquim Olinto Branco; Marcelo Gentil Avilar

346

Water Supply and Use in Deaf Smith, Swisher, and Nearby Counties in the Texas Panhandle.  

National Technical Information Service (NTIS)

Irrigation for agriculture is the primary water use in the area of Deaf Smith and Swisher Counties, Texas, and the Ogallala Formation is the main water source. The availability of water in the 12-county area is projected to decrease markedly over the next...

1985-01-01

347

Ground-water conditions in the Triassic aquifer in Deaf Smith and Swisher Counties  

Microsoft Academic Search

In April 1984, the Director of the Nuclear Waste Programs of the Governor's Office requested a study be undertaken by the Texas Department of Water Resources on the ground-water conditions in the Triassic aquifer in Deaf Smith and Swisher Counties. The need for the study was prompted by the U.S. Department of Energy's (DOE) announcement that consideration was being given

Duffin

1984-01-01

348

Automatic classification of land cover on Smith Island, VA, using HyMAP imagery  

Microsoft Academic Search

Automatic land cover classification maps were developed from Airborne Hyperspectral Scanner (HyMAP) imagery acquired May 8, 2000 over Smith Island, VA, a barrier island in the Virginia Coast Reserve. Both unsupervised and supervised classification approaches were used to create these products to evaluate relative merits and to develop models that would be useful to natural resource managers at higher spatial

Charles M. Bachmann; Timothy F. Donato; Gia M. Lamela; W. Joseph Rhea; Michael H. Bettenhausen; Robert A. Fusina; Kevin R. Du Bois; John H. Porter; Barry R. Truitt

2002-01-01

349

Back to the Future on Gender and Anti-School Boys: A Response to Jeffrey Smith  

ERIC Educational Resources Information Center

|This article examines recent claims by Jeffrey Smith that: (1) "hegemonic masculinity" is an expression of working class counter-school culture; (2) some teachers are "cultural accomplices" in constructing "hegemonic masculinities" of anti-school working class boys, thereby contributing to their underachievement; and (3) these "cultural…

Abraham, John

2008-01-01

350

Distinctiveness and correlates of maladaptive behaviour in children and adolescents with Smith-Magenis syndrome.  

PubMed

This two-part study examines the distinctiveness and correlates of maladaptive behaviour in 35 children and adolescents with Smith-Magenis syndrome, a developmental disorder caused by an interstitial deletion of chromosome 17 (p11.2). Study I compares Child Behavior Checklist scores in 35 children with Smith-Magenis syndrome to age- and gender-matched subjects with Prader-Willi syndrome and mixed intellectual disability. Subjects with Smith-Magenis syndrome had significantly higher levels of maladaptive behaviour than the other groups. Although some problems were shared across groups, 12 behaviours differentiated the three groups with 100% accuracy. Study 2 assessed the frequency and correlates of self-injurious and stereotypical behaviours, including unusual features such as nail-yanking, inserting objects into bodily orifices, self-hugging and a 'lick-and flip' behaviour. Nail-yanking and bodily insertions were less common than other types of self-injury, and self-hugs and the 'lick-and flip' stereotypies were seen in about half the sample. Although age and degree of delay were correlated with problem behaviours, sleep disturbance emerged as the strongest predictor of maladaptive behaviour. The implications are discussed for clinical diagnostic ambiguities between the Smith-Magenis and Prader-Willi syndromes, and for intervention. PMID:10030444

Dykens, E M; Smith, A C

1998-12-01

351

Patty Smith Hill, Gifted Early Childhood Educator of the Progressive Era.  

ERIC Educational Resources Information Center

|This article chronicles the development of Patty Smith Hill, eminent educator of the Progressive Era. Hill was largely responsible for adding kindergarten to the elementary school curriculum, was the author of the "Happy Birthday" song, and a member of the Woman's Suffrage Movement. (DB)|

Rudnitski, Rose A.

1995-01-01

352

Smith-Purcell frequency multiplier with synchronization of radiation from a wide electron beam  

SciTech Connect

An orotronlike feedback can provide a significant increase in the selectivity and power of frequency-multiplied Smith-Purcell radiation of the electron bunches formed in the course of self-excitation of a grating surface eigenmode. This method looks promising for efficient terahertz generation from both weakly and mildly relativistic electron beams.

Bratman, V. L.; Fedotov, A. E.; Makhalov, P. B. [Institute of Applied Physics, Russian Academy of Sciences, Nizhny Novgorod (Russian Federation); Rusin, F. S. [Federal State Unitary Enterprise 'VNIIFTRI', Mendeleevo, Moscow region (Russian Federation)

2009-02-09

353

ESTIMATION OF SURPLUS BIOMASS OF CLUPEIDS IN SMITH MOUNTAIN LAKE, VIRGINIA  

EPA Science Inventory

Mean annual estimates of surplus biomass of alewife Alosa pseudoharengus and gizzard shad Dorosoma cepedianum in Smith Mountain Lake, Virginia, were calculated using data on the biomass, growth, and mortality of each clupeid species. Surplus biomass, defined as production over a...

354

Geology of the Smith River: A Virtual Trip Through The Josephine Ophiolite  

NSDL National Science Digital Library

This trip will take you through one of the world's best exposures of oceanic lithosphere (ophiolite). It begins in the mantle (peridotite) and works upward to pillow basalts and overlying sediments. A general overview of the formation and interpretation of an ophiolite is provided as background material to the specific examples found at the Smith River location in northern California.

Bazard, Dave

355

EFFECTS OF SOME TRACE ELEMENTS ON THE BLOOD OF KUWAIT MULLETS 'LIZA MACROLEPS' (SMITH)  

EPA Science Inventory

Haemopathological changes attributed to heavy metal poisoning observed in blood smears of Liza macrolepis (Smith) taken after exposures of 96 h to graded doses (mg/l) of copper (0.11-1.80), lead (1.15-18.36), and mercury (0.04-0.59), in a flow-through marine bioassay system. In g...

356

LIFE HISTORY MONITORING OF SALMONIDS IN THE WEST FORK SMITH RIVER, UMPQUA BASIN, OREGON  

EPA Science Inventory

As a life-cycle monitoring basin for the Oregon Salmon Plan, the Oregon Department of Fish and Wildlife has estimated adult returns, distribution and smolt outmigration of coho, chinook and winter steelhead in the West Fork Smith River since 1998. In 2001/2002, the Environmenta...

357

Smith-chart diagnostics for multi-GHz time-domain-reflectometry dielectric spectroscopy  

NASA Astrophysics Data System (ADS)

A time-domain-reflectometry Smith-chart display is demonstrated to be a valuable diagnostic tool in a variety of situations in time-domain-reflectometry dielectric spectroscopy. A relative reflection coefficient is formed by dividing the Laplace transform of the reflected sample transient by the Laplace transform of the empty-sensor transient and displaying in the complex plane, with the approximate sensor admittance read from susceptance and conductance circles. The Smith chart provides, as a diagnostic tool, an initial estimate of the dielectric behavior in the multi-GHz range and a means of identifying artifacts in acquisition and Laplace transform, in a way which does not require multiple steps of calibration and is only one step removed from the direct transient. Results are presented for a simple 3.5-mm flat sensor immersed in various liquid media, showing variations in the Smith chart for typical variations in sample permittivity, loss, and conductivity. Results are matched to vector network analyzer (VNA) measurement over an identical frequency range, as well as to finite-element field simulation. Results are also presented for a 3.5-mm sensor with various terminating pin lengths, typically employed at low frequencies and low permittivity media to increase sensor capacitance. For an unshielded pin, the Smith chart detects reflections from sample boundaries and measures the effectiveness of shielding used to eliminate these reflections. For a shielded pin, it characterizes the effect of pin length on the susceptance variation and the onset of pin resonance at high frequencies and high-permittivity values. The effect of artifacts appearing in the Smith chart on the actual calibration is shown by tracking them through the calibration process to the final result. Results are also presented for a 9-mm flat termination used for concrete hydration monitoring, showing effects of transmission-line discontinuities within a terminating plug and the onset of waveguide-like modes in a surrounding shield, with results compared to VNA measurement.

Hager, N. E.; Domszy, R. C.; Tofighi, M. R.

2012-02-01

358

The Adventures of Captain John Smith, Pocahontas and a Sundial: Cosmology, Mathematics, and Power at the Time of Jamestown  

NASA Astrophysics Data System (ADS)

While exploring the Chickahominy River in Virginia by canoe in December 1607, Captain John Smith was ambushed by 200 Powhatan Indians and chased into the swamp. Wounded by arrows and mired in the cold mud, Smith surrendered and was led to their chieftain, Opechancanough. Smith played for time. He pulled out his pocket sundial and proceeded to deliver a lecture on astronomy. The Indians marveled at the dancing needle of the magnetic compass, which they could plainly see but not touch because of the glass cover. They apparently thought less of his discourse in a foreign language on the sun, moon, and planets, as within the hour, Smith's captors had him tied to a tree and were ready to shoot him. But then, Opechancanough held the sundial aloft and spared Smith's life. For the next month, Smith was paraded around various Indian villages before being condemned to have his head bashed in. Pocahontas, however, threw herself across Smith's body in order to save his life. This legendary episode reveals more than Smith's ingenuity. His compass sundial, shaped and marked like a celestial globe, was a microcosm of his universe. It embodied the belief that the smallest things mirrored the large, that number was the key to God's creation, and that by means of mathematical instruments, men could dominate that world (or at least extricate themselves from tight spots!). This paper will examine the astronomical ideas and instruments on which these beliefs were based, and show how ultimately, Smith's sundial also represented the clash of two cosmologies-that of the Indians and European settlers.

Schechner, Sara J.

2007-12-01

359

Distortion of the Terminal Portion of the QRS on the Admission Electrocardiogram in Acute Myocardial Infarction and Correlation With Infarct Size and Long-Term Prognosis (Thrombolysis In Myocardial Infarction 4 Trial) * * This study was supported in part by a grant from SmithKline Beecham, Philadelphia, Pennsylvania  

Microsoft Academic Search

Previous studies have shown an association between distortion of the terminal portion of the QRS (QRS[+] pattern: emergence of the J point ?50% of the R wave in leads with qR configuration, or disappearance of the S wave in leads with an Rs configuration) on admission and in-hospital mortality in acute myocardial infarction (AMI). However, the mechanism for this association

Yochai Birnbaum; Robert A. Kloner; Samuel Sclarovsky; Christopher P. Cannon; Carolyn H. McCabe; Vicki G. Davis; Barry L. Zaret; Frans J. Th. Wackers; Eugene Braunwald

1996-01-01

360

76 FR 61110 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...  

Federal Register 2010, 2011, 2012, 2013

...Formerly: Aegis Sciences Corporation, Aegis...501-202-2783. (Formerly: Forensic Toxicology Laboratory...Medical Center, Forensic Toxicology Laboratory...SmithKline Bio-Science Laboratories...SmithKline Bio-Science Laboratories...305-593-2260. U.S. Army Forensic Toxicology...

2011-10-03

361

78 FR 59946 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...  

Federal Register 2010, 2011, 2012, 2013

...Formerly: Aegis Sciences Corporation, Aegis...501-202-2783, (Formerly: Forensic Toxicology Laboratory...Medical Center, Forensic Toxicology Laboratory...SmithKline Bio-Science Laboratories...SmithKline Bio-Science Laboratories...573-882-1273. U.S. Army Forensic Toxicology...

2013-09-30

362

76 FR 161 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...  

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...Formerly: Aegis Sciences Corporation, Aegis...501-202-2783. (Formerly: Forensic Toxicology Laboratory...Medical Center,Forensic Toxicology Laboratory...SmithKline Bio-Science Laboratories...SmithKline Bio-Science Laboratories...305-593-2260. U.S. Army Forensic Toxicology...

2011-01-03

363

75 FR 39023 - Current List of Laboratories Which Meet Minimum Standards To Engage in Urine Drug Testing for...  

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...Formerly: Aegis Sciences Corporation, Aegis...501-202-2783. (Formerly: Forensic Toxicology Laboratory...Medical Center, Forensic Toxicology Laboratory...SmithKline Bio-Science Laboratories) Quest...SmithKline Bio-Science Laboratories) Quest...305-593-2260. US Army Forensic Toxicology...

2010-07-07

364

77 FR 32653 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...  

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...Formerly: Aegis Sciences Corporation, Aegis...501-202-2783, (Formerly: Forensic Toxicology Laboratory...Laboratories; SmithKline Bio-Science Laboratories). Quest...Laboratories; SmithKline Bio-Science Laboratories). Quest...573-882-1273. US Army Forensic Toxicology Drug...

2012-06-01

365

Estimated transportation routes to a candidate salt repository site in Deaf Smith County, Texas  

SciTech Connect

This report presents a preliminary analysis of possible highway and rail transportation routes within Texas, Oklahoma, and New Mexico for shipments of spent fuel to the candidate repository site in Deaf Smith County, Texas. Two cases are examined for highway shipments. The initial case analyzes shipments following the Department of Transportation's HM-164 regulations for shipment of spent fuel. The second case analyzes normal commercial routes. Three rail cases are also examined. Each case analyzes potential routes that would be used based for different access spurs into the repository site. Two appendices are included which examine additional scenarios generated by restricting routes from passing through various metropolitan areas. The major finding is that most shipments to the Deaf Smith site will pass through Amarillo, Texas. There are few, if any, feasible alternative routes which would significantly reduce the amount of traffic passing through Amarillo.

Joy, D.S.; Johnson, P.E.

1987-10-01

366

Ka-band microwave generation using the Smith-Purcell effect  

SciTech Connect

The CERETRON microwave generator concept relies on the conversion of intense relativistic electron beam (REB) energy into highpower microwave emission through the Smith-Purcell effect. We report initial results from experiments with the production of Ka-band Smith-Purcell radiation generated by a 50-kA, 2.8-MeV beam propagated through a cylindrical transmission grating with lambda/sub 0/ = 1 cm. These experiments were performed without a quasi-optical resonator, and the output was limited by breakdown of the grating and by limited access through the 90-kG magnet coil. Nevertheless, the measured power output from these initial experiments was about 7 kW in the Ka band.

Ekdahl, C.A.; Davis, H.A.

1983-01-01

367

?1-adrenergic antagonists improve sleep and behavioural disturbances in a circadian disorder, Smith-Magenis syndrome  

PubMed Central

Smith-Magenis syndrome (SMS) is a clinically recognisable contiguous gene syndrome ascribed to interstitial deletions of chromosome 17p11.2. Patients have a phase shift of their circadian rhythm of melatonin with a paradoxical diurnal secretion of the hormone. Serum melatonin levels and day-night behaviour were studied in nine SMS children (aged 4 to 17 years) given acebutolol, a selective ?1-adrenergic antagonist (10 mg/kg early in the morning). Cardiac examination, serum melatonin, motor activity recordings, and sleep diaries were monitored before and after drug administration. The present study shows that a single morning dose of acebutolol suppressed the inappropriate secretion of melatonin in SMS. A significant improvement of inappropriate behaviour with increased concentration, delayed sleep onset, increased hours of sleep, and delayed waking were also noted. These results suggest that ?1-adrenergic antagonists help to manage hyperactivity, enhance cognitive performance, and reduce sleep disorders in SMS.???Keywords: Smith-Magenis syndrome; circadian rhythms; melatonin

De Leersnyder, H.; de Blois, M.-C.; Vekemans, M.; Sidi, D.; Villain, E.; Kindermans, C.; Munnich, A.

2001-01-01

368

160-fold acceleration of the Smith-Waterman algorithm using a field programmable gate array (FPGA)  

PubMed Central

Background To infer homology and subsequently gene function, the Smith-Waterman (SW) algorithm is used to find the optimal local alignment between two sequences. When searching sequence databases that may contain hundreds of millions of sequences, this algorithm becomes computationally expensive. Results In this paper, we focused on accelerating the Smith-Waterman algorithm by using FPGA-based hardware that implemented a module for computing the score of a single cell of the SW matrix. Then using a grid of this module, the entire SW matrix was computed at the speed of field propagation through the FPGA circuit. These modifications dramatically accelerated the algorithm's computation time by up to 160 folds compared to a pure software implementation running on the same FPGA with an Altera Nios II softprocessor. Conclusion This design of FPGA accelerated hardware offers a new promising direction to seeking computation improvement of genomic database searching.

Li, Isaac TS; Shum, Warren; Truong, Kevin

2007-01-01

369

Smith Institute: New and Emerging Themes in Industrial and Applied Mathematics (NETIAM)  

NSDL National Science Digital Library

New and Emerging Themes in Industrial and Applied Mathematics (NETIAM) is a project of the Smith Institute and supported by the European Commission's programme in New and Emerging Science and Technology (NEST). Starting in March 2004 and lasting for 15 months, the project brings together researchers from the Smith Institute, Fraunhofer-ITWM in Germany, the Technical University of Eindhoven in The Netherlands, the University of Firenze in Italy and Ventspils University College in Latvia. Using mathematical frameworks, they will identify ground-breaking research directions in four themes: modelling the business environment; modelling criminality in the social environment; visualization and simulation of materials; and complexity at the molecular level. Thematic Workshops "will exploit the brainstorming capabilities of the participants in a facilitated think-tank environment" and a final plenary workshop will report the results of their work. The website provides additional information on the project and invites researchers to join in the Thematic Workshops.

2006-01-06

370

77 FR 442 - Changes To Implement Miscellaneous Post Patent Provisions of the Leahy-Smith America Invents Act  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF COMMERCE United States Patent and Trademark Office 37 CFR Part 1...Changes To Implement Miscellaneous Post Patent Provisions of the Leahy-Smith America Invents Act AGENCY: United States Patent and Trademark Office, Commerce....

2012-01-05

371

ONWI (Office of Nuclear Waste Isolation) 30% design review findings report for Exploratory Shaft Facility, Deaf Smith site  

SciTech Connect

This document describes a review of the standards for the design of the high-level radioactive waste facility at the Deaf Smith, Texas site. It includes public comments and the official responses to the designs produced to date. (TEM)

Not Available

1987-05-08

372

77 FR 4982 - Solicitation of Input From Stakeholders Regarding the Smith-Lever 3(d) Extension Integrated Pest...  

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...Agriculture Solicitation of Input From Stakeholders Regarding the Smith-Lever 3(d...Notice of public meeting and request for stakeholder input...Program (EIPM). 2:15-4 p.m. Stakeholder input on general administration of...

2012-02-01

373

77 FR 9890 - Solicitation of Input From Stakeholders Regarding the Smith-Lever 3(d) Children, Youth, and...  

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2012-02-21

374

77 FR 30047 - Notice of Opportunity for Public Comment on Surplus Property Release at Michael J Smith Field...  

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...DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Notice of Opportunity for Public Comment on Surplus Property Release at Michael J Smith Field, Beaufort, NC AGENCY: Federal Aviation Administration (FAA), DOT....

2012-05-21

375

76 FR 72675 - Voluntary Termination of Foreign-Trade Subzone 90A Smith Corona Corporation, Cortland County, New...  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF COMMERCE Foreign-Trade Zones Board [Order No. 1799] Voluntary Termination of Foreign-Trade Subzone 90A Smith Corona Corporation...the authority granted in the Foreign-Trade Zones Act of June 18,...

2011-11-25

376

Largemouth Bass Predation on Stocked Striped Bass in Smith Mountain Lake, Virginia  

Microsoft Academic Search

First-year survival of striped bass Morone saxatilis stocked into lakes and reservoirs is often poor, but causes of mortality have not been determined. We quantified losses of stocked, age-0 striped bass to predation by largemouth bass Micropterus salmoidesin Smith Mountain Lake, Virginia, where first-year striped bass survival averages 25% and the largemouth bass is the principal littoral piscivore. To examine

Daniel P. Michaelson; John J. Ney; Trent M. Sutton

2001-01-01

377

A Comparison of Coarse Bedload Transport Measured with Bedload Traps and Helley-Smith Samplers  

Microsoft Academic Search

Gravel bedload transport rates were measured at eight study sites in coarse-bedded Rocky Mountain streams using 4-6 bedload traps deployed across the stream width and a 76 by 76 mm opening Helley Smith sampler. Transport rates obtained from bedload traps increased steeply with flow which resulted in steep and well-defined transport rating curves with exponents of 8 to 16. Gravel

Kristin Bunte; Steven R. Abt; John P. Potyondy; Kurt W. Swingle

2008-01-01

378

Reduced greasiness of ‘Granny Smith’ apples washed in Tween 20 solution  

Microsoft Academic Search

‘Granny Smith’ apples (Malus domestica Borkh.) tend to develop greasy skins after extended storage which makes them slippery to touch and reduces their aesthetic appeal. Washing fruit in 0.15% (w\\/w) Tween 20 surfactant solution reduced greasiness, loss of greenness, and firmness after 22 days at 20°C. These effects were associated with decreased skin permeance to gases, depressed internal oxygen (O2)

B. K. Dadzie; N. H. Banks; E. W. Hewett; D. J. Cleland

1995-01-01

379

The angular distribution of the power produced by Smith - Purcell radiation  

NASA Astrophysics Data System (ADS)

The radiation produced by the interaction of an electron beam with a metallic grating (the Smith - Purcell radiation) can be described in terms of a theory based on the acceleration of the surface charges induced on the grating surface by the passing electrons. The calculated spectral distribution of the emitted power is compared with recent experimental results; the agreement between the two is found to be satisfactory.

Brownell, J. H.; Doucas, G.; Kimmitt, M. F.; Mulvey, J. H.; Omori, M.; Walsh, J. E.

1997-09-01

380

Extension of the Mott-Smith Method for a One-Dimensional Shock Wave  

Microsoft Academic Search

A method has been developed for adding an arbitrary number of additional terms to the two-term Mott-Smith distribution function for a one-dimensional shock wave and a calculation has been carried out, for a monatomic gas of Maxwellian molecules, with a three term distribution function. For weak shocks, the calculated reciprocal shock thicknesses are within 2% of the Navier-Stokes results. This

Harold Salwen; Chester E. Grosch; Sigi Ziering

1964-01-01

381

Obwervation of 10 {mu}m Smith-Purcell radiation from 45 MeV electrons  

SciTech Connect

Using the high-brightness, high-energy electron beam at the Brookhaven Accelerator Test Facility we observe forward directed Smith-Purcell radiation in the mid-infrared spectral regime. This radiation can prove useful as a source of infrared radiation for other scientific studies as well as a providing a precursor investigation of the inverse process, namely the acceleration of electrons by means of the coupling of laser light with electrons via micro-structures.

Fernow, R.C. [Brookhaven National Lab., Upton, NY (United States); Robertson, S.H. [Colorado Univ., Boulder, CO (United States). Dept. of Physics; Brownell, J.H.; Walsh, J.E. [Dartmouth Coll., Hanover, NH (United States). Dept. of Physics and Astronomy

1997-02-01

382

Energy conservation study on Smith Frozen Foods processing plant, Weston, Oregon  

SciTech Connect

A comprehensive energy study was performed at Smith Frozen Foods in Weston, Oregon, in the fall of 1984. The plant processes corn, peas, lima beans and carrots. The products are inspected, prepared and graded before being sent through freeze tunnels. The frozen products are dumped into tote bins which are transported into cold storage warehouses. Energy conservation measures were calculated using a modified return on investment analysis called a return on capital (ROC) analysis and current rate schedules.

Not Available

1985-01-02

383

Essential Oils of Etlingera elatior (Jack) R. M. Smith and Etlingera littoralis (Koenig) Giseke  

Microsoft Academic Search

The essential oils obtained by hydrodistillation of the leaves, rhizomes and roots of Etlingera elatior (Jack) R. M. Smith and a white-flowered variety known as Thai queen, and Etlingera littoralis (Koenig) Giseke were analyzed by capillary GC and GC\\/MS. The oils of E. elatior were dominated by mono- and sesquiterpenoids, with the major components being myrcene (13.5%), ?-humulene (11.8%) and

K. C. Wong; Y. Sivasothy; P. L. Boey; H. Osman; B. Sulaiman

2010-01-01

384

Defence transcriptome profiling of Zingiber zerumbet (L.) Smith by mRNA differential display  

Microsoft Academic Search

Soft rot is a serious disease in ginger (Zingiber officinale Roscoe), imposing a considerable economic loss annually in all ginger-producing countries. In this study, mRNA differential\\u000a display was employed to identify genes whose expression was altered in a soft rot-resistant accession of Zingiber zerumbet (L.) Smith, a wild relative of ginger, in response to Pythium aphanidermatum (Edson) Fitzp., which is

P. G. Kavitha; George Thomas

2008-01-01

385

A modified Smith predictor for controlling a process with an integrator and long dead-time  

Microsoft Academic Search

A modification of the Smith predictor for controlling higher-order processes with integral action and long dead-time is proposed. The controller has a quite simple structure which is obtained based on the model consisting of an ideal integrator and dead-time and which includes only three tuning parameters: the dead-time, velocity gain of the model, and the desired time constant of the

M. R. Matausek; Aleksandar D. Micic

1996-01-01

386

Simvastatin: a new therapeutic approach for Smith-Lemli-Opitz syndrome  

Microsoft Academic Search

The Smith-Lemli-Opitz syndrome (SLOS) is caused by deficient D 7 -dehydrocholesterol reductase, which catalyzes the final step of the cholesterol biosynthetic path- way, resulting in low cholesterol and high concentrations of its direct precursors 7-dehydrocholesterol (7DHC) and 8DHC. We hypothesized that i ) 7DHC and 8DHC accumula- tion contributes to the poor outcome of SLOS patients and ii ) blood

Petr E. Jira; Ron A. Wevers; Jan de Jong; Estela Rubio-Gozalbo; Fokje S. M. Janssen-Zijlstra; Arno F. J. van Heyst; Rob C. A. Sengers; Jan A. M. Smeitink

387

BLAZETM: An Implementation of the Smith-Waterman Sequence Comparison Algorithm on a Massively Parallel Computer  

Microsoft Academic Search

We have implemented the Smith and Waterman dynamic programming algorithm on the massively parallel MP1104 computer from MasPar and compared its ability to detect remote protein sequence homologies with that of other commonly used database search algorithms. Dynamic programming algorithms are normally too computer intensive to permit full databases search, however on the MP1104 a search of the Swiss-Prot database

Douglas L. Brutlag; Jean-pierre Dautricourt; Ron Diaz; Jeff Fier; Bruce Moxon; Richard Stamm

1993-01-01

388

Antimicrobial activity of aerial parts of Drosera peltata Smith on oral bacteria.  

PubMed

The antimicrobial activity of extracts of aerial parts of Drosera peltata Smith against oral bacteria was investigated using agar diffusion and dilution micromethods. The chloroformic extract, active against all the bacteria tested, showed the most significant antimicrobial properties. Plumbagin, isolated from the extract, is the active principle. Results obtained suggest that Drosera peltata extract could be used in the treatment of oral infectious diseases like dental caries and periodontitis. PMID:9533437

Didry, N; Dubreuil, L; Trotin, F; Pinkas, M

1998-02-01

389

Psychiatric disorder and suicide in the military, then and now: commentary on Frueh and Smith.  

PubMed

Consulting archival medical data from the American Civil War, Frueh and Smith found little evidence of mental disorders, no evidence of reexperiencing symptoms suggestive of posttraumatic stress disorder, but a notable rate of suicide. In this commentary, I suggest reasons why the archives contain so few traces of combat-related disorders despite the massive trauma experienced by soldiers in the Civil War, and I draw implications for military personnel returning from the wars in Iraq and Afghanistan. PMID:22858106

McNally, Richard J

2012-07-14

390

Exactly solvable nonlinear model for a Smith-Purcell free-electron laser  

SciTech Connect

We present a model for a Smith-Purcell free-electron laser, including nonlinear effects, that can be solved in closed form. The model is shown to obey the pendulum equation. The average electron efficiency calculated by means of this model is compared with that obtained from an exact numerical calculation and from a simpler ''phase-space'' model for a wide range of physical parameters.

Crowne, F.J.; Leavitt, R.P.; Worchesky, T.L.

1981-08-01

391

Cardiorespiratory function of swimming blue crab Callinectes danae Smith, during normoxia and graded hypoxia  

Microsoft Academic Search

Swimming blue crabs Callinectes danae Smith were studied as to the respiratory (oxygen uptake, MO2 and scaphognathite beat frequency, fsc) and cardiac (ECG and heart beat frequency, fH) responses to normoxia (154 mmHg) and graded hypoxia (130, 100, 70, 50, 30 and 20 mmHg). C. Danae kept constant MO2 from normoxia until the critical oxygen tension (PcO2) of 97 mmHg

Francisco Tadeu Rantin; Ana Lúcia Kalinin; JoséCarlos de Freitas

1996-01-01

392

An efficient and high performance linear recursive variable expansion implementation of the Smith-Waterman algorithm.  

PubMed

In this paper, we present an efficient and high performance linear recursive variable expansion (RVE) implementation of the Smith-Waterman (S-W) algorithm and compare it with a traditional linear systolic array implementation. The results demonstrate that the linear RVE implementation performs up to 2.33 times better than the traditional linear systolic array implementation, at the cost of utilizing 2 times more resources. PMID:19963596

Hasan, Laiq; Al-Ars, Zaid

2009-01-01

393

The near universal presence of autism spectrum disorders in children with Smith–Lemli–Opitz syndrome  

Microsoft Academic Search

Smith-Lemli-Opitz syndrome (SLOS) is an autosomal recessive condition caused by a defect in cholesterol synthesis. Affected children often have malformations and mental retardation. Autistic behaviors also are evident. The purpose of the present study was to determine the prevalence of autism spectrum disorders (ASDs) in children with SLOS. Fourteen children, 3-16 years old, were evaluated using three different methods to

Darryn M. Sikora; Kersti Pettit-Kekel; Jennifer Penfield; Louise S. Merkens; Robert D. Steiner

2006-01-01

394

Significance of Z-value statistics of Smith-Waterman scores for protein alignments  

Microsoft Academic Search

The Z-value is an attempt to estimate the statistical significance of a Smith-Waterman dynamic alignment score (SW-score) through the use of a Monte-Carlo process. It partly reduces the bias induced by the composition and length of the sequences. This paper is not a theoretical study on the distribution of SW-scores and Z-values. Rather, it presents a statistical analysis of Z-values

J. P. Comet; J. C. Aude; E. Glemet; J. L. Risler; A. Henaut; J. J. Codani; Jean-Christophe Aude; Jean-Jacques Codani

2001-01-01

395

Cholesterol Deficit in Autism: Insights from Smith–Lemli–Opitz Syndrome  

Microsoft Academic Search

\\u000a Cholesterol is necessary for neuroactive steroid production, growth of myelin membranes, and normal embryonic and fetal development.\\u000a It also modulates the oxytocin receptor, as well as ligand activity and G-protein coupling of the serotonin-1A receptor. A\\u000a deficit of cholesterol may perturb these biological processes and thereby contribute to autism spectrum disorders (ASD), as\\u000a observed in Smith–Lemli–Opitz syndrome (SLOS) and some

Alka Aneja; Elaine Tierney

396

Abnormal cholesterol biosynthesis in sitosterolaemia and the Smith-Lemli-Opitz syndrome  

Microsoft Academic Search

Summary We investigated the enzyme defects in two inherited disorders of cholesterol biosynthesis: sitosterolaemia and the Smith-Lemli-Opitz syndrome. In sitosterolaemic homozygotes, plasma plant sterols (sitosterol and campesterol) concentrations are elevated because of enhanced intestinal absorption and diminished removal. Underlying these changes is very low cholesterol biosynthesis to provide extra sterol for cell growth. Extremely reduced activities of HMG-CoA reductase, the

G. Salen; S. Shefer; A. K. Batta; G. S. Tint; G. Xu; A. Honda

1996-01-01

397

Abnormal cholesterol biosynthesis as in Smith-Lemliopitz syndrome disrupts normal skeletal development in the rat  

Microsoft Academic Search

Smith-Lemli-Opitz syndrome (SLOS) in human infants is a common autosomal recessive malformation syndrome (estimated incidence, 1:20,000). It is characterized clinically by congenital anomalies, especially craniofacial and limb defects, and biochemically by a defect in 7-dehydrocholesterol-?7-reductase activity (7DHC- reductase), the final enzyme in cholesterol biosynthesis. In previous studies, early administration of the 7DHC-reductase inhibitor AY9944 to pregnant rats resulted in a

Martine Kolf-Clauw; Francoise Chevy; Claire Ponsart

1998-01-01

398

Highly enantioselective Simmons-Smith fluorocyclopropanation of allylic alcohols via the halogen scrambling strategy of zinc carbenoids.  

PubMed

Highly enantio- and diastereoenriched monofluorocyclopropanes were accessed via the Simmons-Smith fluorocyclopropanation of allylic alcohols using difluoroiodomethane and ethylzinc iodide as the substituted carbenoid precursors. The scrambling of halogens at the zinc carbenoid led to the formation of the fluorocyclopropanating agent (fluoroiodomethyl)zinc(II) fluoride. This strategy circumvented the ongoing limitation in Simmons-Smith fluorocyclopropanations relying on the use of the relatively inaccessible and expensive carbenoid precursor fluorodiiodomethane. PMID:23659635

Beaulieu, Louis-Philippe B; Schneider, Jakob F; Charette, André B

2013-05-20

399

William Peirce and E.A. Cappelen Smith and their amazing copper converting machine  

NASA Astrophysics Data System (ADS)

This is the story of how technology advances allowed the copper industry to realize its full potential. The Peirce-Smith Converting Centennial symposium, to be held at the TMS 2009 Annual Meeting, will celebrate the contributions of two men, William Peirce and E.A.C. Smith, in these advances. However, theirs is representative of a larger story: New, simpler technology releasing the stranglehold of older, more complicated technology, new developments in vessel configuration and design finding alternate routes around dead ends in operability, advances in technique and concepts removing roadblocks of cycle time and capacity, and overall innovation opening up vast new reserves around the world to those companies willing to embrace those improvements. Our story is also one of personalities, stubborn smeltermen versus the innovators, those inside the industry versus those from outside. It is a story of an initial borrowing from the steel industry, but also Peirce and Smith, from the refining end of the copper business, taking the ideas of Baggaley from Pittsburgh’s steel and air-brake industry, who built on what Hollway, Manhès and David, Douglas, and others had done in smelter tests, further to compete with the previous primacy and closely held expertise of the copper smeltermen in Wales. The photos presented illustrate these innovations.

Southwick, Larry M.

2008-10-01

400

The Smith Stream: A High Velocity Cloud crossing the Milky Way Disk  

NASA Astrophysics Data System (ADS)

The Smith Cloud is a high-velocity HI cloud with the following extraordinary properties: it is located about 12 kpc from the Sun but less than 8 kpc from the Galactic Center, and it's tip is currently about 2 kpc below the Galactic plane. Its complete space motion is known and it is on a trajectory to cross the Galactic plane in about 30 Myr. Its size is >3 x >1 kpc, and it contains more than two million solar masses of ionized and neutral Hydrogen. Recent new HI observations with the NRAO Green Bank Telescope have revealed a series of small HI clouds over an area ahead of the Smith Cloud that have kinematics and locations consistent with following the same trajectory as the Cloud. Their spectra suggests that they are interacting strongly with the local ISM. The implication is that that the Smith Cloud is the largest object along a stream of gas more than 6 kpc in extent, some of which has already passed through the Galactic plane. The National Radio Astronomy Observatory is a facility of the National Science Foundation, operated under a cooperative agreement by Associated Universities, Inc.

Lockman, Felix J.

2012-05-01

401

Smith-Lemli-Opitz syndrome is caused by mutations in the 7-dehydrocholesterol reductase gene.  

PubMed Central

Smith-Lemli-Opitz syndrome is a frequently occurring autosomal recessive developmental disorder characterized by facial dysmorphisms, mental retardation, and multiple congenital anomalies. Biochemically, the disorder is caused by deficient activity of 7-dehydrocholesterol reductase, which catalyzes the final step in the cholesterol-biosynthesis pathway-that is, the reduction of the Delta7 double bond of 7-dehydrocholesterol to produce cholesterol. We identified a partial transcript coding for human 7-dehydrocholesterol reductase by searching the database of expressed sequence tags with the amino acid sequence for the Arabidopsis thaliana sterol Delta7-reductase and isolated the remaining 5' sequence by the "rapid amplification of cDNA ends" method, or 5'-RACE. The cDNA has an open reading frame of 1,425 bp coding for a polypeptide of 475 amino acids with a calculated molecular weight of 54.5 kD. Heterologous expression of the cDNA in the yeast Saccharomyces cerevisiae confirmed that it codes for 7-dehydrocholesterol reductase. Chromosomal mapping experiments localized the gene to chromosome 11q13. Sequence analysis of fibroblast 7-dehydrocholesterol reductase cDNA from three patients with Smith-Lemli-Opitz syndrome revealed distinct mutations, including a 134-bp insertion and three different point mutations, each of which was heterozygous in cDNA from the respective parents. Our data demonstrate that Smith-Lemli-Opitz syndrome is caused by mutations in the gene coding for 7-dehydrocholesterol reductase.

Waterham, H R; Wijburg, F A; Hennekam, R C; Vreken, P; Poll-The, B T; Dorland, L; Duran, M; Jira, P E; Smeitink, J A; Wevers, R A; Wanders, R J

1998-01-01

402

The Edwin Smith Papyrus: the birth of analytical thinking in medicine and otolaryngology.  

PubMed

The Edwin Smith Papyrus, discovered in 1862 outside of Luxor, Egypt, is the oldest known surgical text in the history of civilization. The surviving scroll, a copy of an earlier text from around 3,000 B.C., gives us remarkable insight into the medical practice of ancient Egyptians in the Nile River bed during the dawn of civilization. The Papyrus is divided into 48 cases, most of which describe traumatic injuries. The text instructs the physician to examine the patient and look for revealing physical signs that may indicate the outcome of the injury. Although in modern medicine we take for granted that the use of physical examination and rational thinking lead to an accurate conclusion, 5,000 years ago, this was extraordinary. The Edwin Smith Papyrus cast aside the prevailing magic and mysticism of that time in favor of logic and deductive reasoning. As Egyptian civilization declined during the next millennium, the teachings of the Papyrus would be lost. It would not be until 300 B.C. when Hippocrates and his disciples in ancient Greece would once again revive logic in medical thinking and teaching. It is believed that the ancient Greeks had knowledge of the contents of the Edwin Smith Papyrus and its teachings and used them as the basis for their writings. As Europe entered the Dark Ages, so did medicine yet again, reverting to spells and prayers instead of judgment and reason. Although Hippocrates teachings were recognized by some scholars during the Middle Ages, they did not make up the basis for mainstream medical knowledge. With the dawn of the Renaissance, medicine would finally purge itself of its past supernatural foundation. Hippocratic teachings were used to form the basis of modern medicine, and medical pioneers in the 17 century studied the ancient Greek texts as the origin for their ideas. Many of the concepts physicians and patients today take as common knowledge originated in the Edwin Smith Papyrus. The authors attempt to uncover some of these fundamental ideas and trace them through time until their incorporation in our modern medical knowledge base. It is the rational, logical, and advanced thinking exhibited in the Edwin Smith Papyrus that mandates its respect from modern otolaryngologists and all physicians alike. PMID:16467701

Stiefel, Marc; Shaner, Arlene; Schaefer, Steven D

2006-02-01

403

CUDASW++: optimizing Smith-Waterman sequence database searches for CUDA-enabled graphics processing units  

PubMed Central

Background The Smith-Waterman algorithm is one of the most widely used tools for searching biological sequence databases due to its high sensitivity. Unfortunately, the Smith-Waterman algorithm is computationally demanding, which is further compounded by the exponential growth of sequence databases. The recent emergence of many-core architectures, and their associated programming interfaces, provides an opportunity to accelerate sequence database searches using commonly available and inexpensive hardware. Findings Our CUDASW++ implementation (benchmarked on a single-GPU NVIDIA GeForce GTX 280 graphics card and a dual-GPU GeForce GTX 295 graphics card) provides a significant performance improvement compared to other publicly available implementations, such as SWPS3, CBESW, SW-CUDA, and NCBI-BLAST. CUDASW++ supports query sequences of length up to 59K and for query sequences ranging in length from 144 to 5,478 in Swiss-Prot release 56.6, the single-GPU version achieves an average performance of 9.509 GCUPS with a lowest performance of 9.039 GCUPS and a highest performance of 9.660 GCUPS, and the dual-GPU version achieves an average performance of 14.484 GCUPS with a lowest performance of 10.660 GCUPS and a highest performance of 16.087 GCUPS. Conclusion CUDASW++ is publicly available open-source software. It provides a significant performance improvement for Smith-Waterman-based protein sequence database searches by fully exploiting the compute capability of commonly used CUDA-enabled low-cost GPUs.

Liu, Yongchao; Maskell, Douglas L; Schmidt, Bertil

2009-01-01

404

Homeopathy and extraordinary claims--a response to Smith's utilitarian argument.  

PubMed

Kevin Smith's utilitarian argument against homeopathy(1) is flawed because he did not review and refute the relevant basic science literature on ultra-high dilutions. He also failed to appreciate that allopathic medicine is based on a deductive-nomothetic method and that homeopathic medicine is based on an inductive-idiographic method, and thus that the implications for clinical research are very different. His misunderstanding of provings and of the holism of homeopathic medicine also demonstrated his failure to understand the history, philosophy and method of homeopathy. Finally, I questioned the value of introducing ethical judgment into an ongoing scientific debate. PMID:22506685

Sebastian, Irene

2012-04-17

405

LIGHT SOURCE: Design of a new compact THz source based on Smith-Purcell radiation  

NASA Astrophysics Data System (ADS)

In recent years, people are dedicated to the research work of finding compact THz sources with high emission power. Smith-Purcell radiation is qualified for the possibility of coherent enhancement due to the effect of FEL mechanism. The compact experiment device is expected to produce hundreds mW level THz ray. The electron beam with good quality is provided under the optimized design of the electron gun. Besides, the grating is designed as an oscillator without any external feedbacks. While the beam passes through the grating surface, the beam bunching will be strong and the second harmonics enhancement will be evident, as is seen from the simulation results.

Dai, Dong-Dong; Bei, Hua; Dai, Zhi-Min

2009-06-01

406

Air pollutant emission rates for sources at the Deaf Smith County repository site  

SciTech Connect

This document summarizes the air-quality source terms used for the Deaf Smith County, Texas environmental assessment report and explains their derivation. The engineering data supporting these source terms appear as appendixes to this report and include summary equipment lists for the repository and detailed equipment lists for the exploratory shaft. Although substantial work has been performed in establishing the current repository design, a greater effort will be required for the final design. Consequently, the repository emission rates presented here should be considered as preliminary estimates. Another set of air pollution emission rates will be calculated after design data are more firmly established. 18 refs., 15 tabs.

Not Available

1985-11-01

407

Basic repository source term and data sheet report: Deaf Smith County  

SciTech Connect

This report is one of a series describing studies undertaken in support of the US Department of Energy Civilian Radioactive Waste Management (CRWM) Program. This study contains the derivation of values for environmental source terms and resources consumed for a CRWM repository. Estimates include heavy construction equipment; support equipment; shaft-sinking equipment; transportation equipment; and consumption of fuel, water, electricity, and natural gas. Data are presented for construction and operation at an assumed site in Deaf Smith County, Texas. 2 refs., 6 tabs.

Not Available

1987-01-01

408

Hydrogeologic testing plan for Deep Hydronest Test Wells, Deaf Smith County site, Texas  

SciTech Connect

This report discusses methods of hydraulic testing which are recommended for use in the Deep Hydronest Test Wells at the proposed high level nuclear waste repository site in Deaf Smith County, Texas. The deep hydronest wells are intended to provide geologic, geophysical and hydrologic information on the interval from the Upper San Andres Formation to the base of the Pennsylvanian system at the site. Following the period of drilling and testing, the wells will be converted into permanent monitoring installations through which fluid pressures and water quality can be monitored at various depths in the section. 19 refs., 17 figs., 2 tabs.

Not Available

1987-12-01

409

Lethal acrodysgenital dwarfism: a severe lethal condition resembling Smith-Lemli-Opitz syndrome.  

PubMed Central

We report eight cases of a lethal association of failure to thrive, facial dysmorphism, ambiguous genitalia, syndactyly, postaxial polydactyly, and internal developmental anomalies (Hirschsprung's disease, cardiac and renal malformation). This syndrome is likely to be autosomal recessive and resembles Smith-Lemli-Opitz (SLO) syndrome. However, the lethality, the common occurrence of polydactyly, and the sexual ambiguity distinguishes this condition from SLO syndrome. A review of published reports supports the separate classification of this syndrome for which we propose the name lethal acrodysgenital dwarfism. Images

Merrer, M L; Briard, M L; Girard, S; Mulliez, N; Moraine, C; Imbert, M C

1988-01-01

410

Sex pheromone of fall armyworm, Spodoptera frugiperda (J.E. Smith)  

Microsoft Academic Search

Analyses of extracts of pheromone glands and of volatiles from calling female fall armyworm moths,Spodoptera frugiperda (J.E. Smith), revealed the presence of the following compounds: dodecan-1-ol acetate, (Z)-7-dodecen-1-ol acetate, 11-dodecen-1-ol acetate, (Z)-9-tetradecenal, (Z)-9-tetradecen-1-ol acetate, (Z)-11-hexadecenal, and (Z)-11-hexadecen-1-ol acetate. The volatiles emitted by calling females differed from the gland extract in that the two aldehydes were absent. Field tests were conducted

J. H. Tumlinson; E. R. Mitchell; P. E. A. Teal; R. R. Heath; L. J. Mengelkoch

1986-01-01

411

Start Current and Gain Measurements for a Smith-Purcell Free-Electron Laser  

SciTech Connect

Coherent Smith-Purcell radiation is a promising source of coherent emission in the THz domain. Although it has been observed in several experiments, some physical quantities related to the bunching of an initially continuous beam had not yet been studied experimentally. Among them, the gain as function of beam current, together with the value of the start current, needed to be addressed. We report here their measurements in a microwave experiment using a sheet beam. A start current of about 20 A/m was found. Two-dimensional simulations with a very thin beam agree well with our results.

Gardelle, J.; Modin, P.; Donohue, J. T. [CEA, CESTA, F-33114 Le Barp (France); Centre d'Etudes Nucleaires de Bordeaux-Gradignan, Universite Bordeaux 1, CNRS/IN2P3, BP 120, 33175 Gradignan (France)

2010-11-26

412

Open reduction of intracapsular hip fractures using a modified Smith-Petersen surgical exposure.  

PubMed

The Smith-Petersen or modified direct anterior hip surgical exposures have not previously been described for open reduction of femoral neck fractures. This technique of reduction provides a direct approach to the femoral neck and hip joint. Displaced fractures of the femoral neck can easily be reduced through this approach, local osseus defects resulting from impaction can be supported with bone graft, and fracture fixation is then placed through a separate lateral exposure or through small stab incisions. The technique of reduction is presented. PMID:17762484

Molnar, Robert B; Routt, M L Chip

2007-08-01

413

Calculation of force and power during bench throws using a Smith machine: the importance of considering the effect of counterweights.  

PubMed

For achieving accurate and safe measurements of the force and power exerted on a load during resistance exercise, the Smith machine has been used instead of free weights. However, because some Smith machines possess counterweights, the equation for the calculation of force and power in this system should be different from the one used for free weights. The purpose of this investigation was to calculate force and power using an equation derived from a dynamic equation for a Smith machine with counterweights and to determine the differences in force and power calculated using 2 different equations. One equation was established ignoring the effect of the counterweights (Method 1). The other equation was derived from a dynamic equation for a barbell and counterweight system (Method 2). 9 female collegiate judo athletes performed bench throws using a Smith machine with a counterweight at 6 different loading conditions. Barbell displacement was recorded using a linear position transducer. The force and power were subsequently calculated by Methods 1 and 2. The results showed that the mean and peak power and force in Method 1 were significantly lower relative to those of Method 2 under all loading conditions. These results indicate that the mean and peak power and force during bench throwing using a Smith machine with counterweights would be underestimated when the calculations used to determine these parameters do not account for the effect of counterweights. PMID:23459856

Kobayashi, Y; Narazaki, K; Akagi, R; Nakagaki, K; Kawamori, N; Ohta, K

2013-03-04

414

Site study plan for borehole search and characterization, Deaf Smith County Site, Texas: Revision 1  

SciTech Connect

This site study plan describes the Borehole Search and Characterization field activities to be conducted during the early stages of Site Characterization at the Deaf Smith County site, Texas. The field program has been designed to provide data useful in addressing information/data needs resulting from Federal/State/Local regulatory requirements and repository program requirements. Air and ground surveys, an extensive literature search, and landowner interviews will be conducted to locate wells within and adjacent to the proposed nuclear waste repository site in Deaf Smith County. Initially, the study will center around the planned Exploratory Shaft Facilities location and will expand outward from that location. Findings from this study may lead to preparation of a new site study plan to search suspected borehole locations, and excavate or reenter known boreholes for additional characterization or remedial action. The Salt Repository Project (SRP) Networks specify the schedule under which the program will operate. The Technical Field Services Contractor (TFSC) is responsible for conducting the field program. Data will be handled and reported in accordance with established SRP procedures. A quality assurance program will be utilized to assure that activities affecting quality are performed correctly and that appropriate documentation is maintained. 13 refs., 6 figs., 3 tabs.

Not Available

1987-12-22

415

GPU-Based Cloud Service for Smith-Waterman Algorithm Using Frequency Distance Filtration Scheme  

PubMed Central

As the conventional means of analyzing the similarity between a query sequence and database sequences, the Smith-Waterman algorithm is feasible for a database search owing to its high sensitivity. However, this algorithm is still quite time consuming. CUDA programming can improve computations efficiently by using the computational power of massive computing hardware as graphics processing units (GPUs). This work presents a novel Smith-Waterman algorithm with a frequency-based filtration method on GPUs rather than merely accelerating the comparisons yet expending computational resources to handle such unnecessary comparisons. A user friendly interface is also designed for potential cloud server applications with GPUs. Additionally, two data sets, H1N1 protein sequences (query sequence set) and human protein database (database set), are selected, followed by a comparison of CUDA-SW and CUDA-SW with the filtration method, referred to herein as CUDA-SWf. Experimental results indicate that reducing unnecessary sequence alignments can improve the computational time by up to 41%. Importantly, by using CUDA-SWf as a cloud service, this application can be accessed from any computing environment of a device with an Internet connection without time constraints.

Lee, Sheng-Ta; Hung, Che Lun

2013-01-01

416

A REVISED METHOD FOR ESTIMATING OXIDE BASICITY PER THE SMITH SCALE WITH EXAMPLE APPLICATION TO GLASS DURABILITY  

SciTech Connect

Previous researchers have developed correlations between oxide electronegativity and oxide basicity. The present paper revises those correlations using a newer method of calculating electronegativity of the oxygen anion. Basicity is expressed using the Smith {alpha} parameter scale. A linear relation was found between the oxide electronegativity and the Smith {alpha} parameter, with an R{sup 2} of 0.92. An example application of this new correlation to the durability of high-level nuclear waste glass is demonstrated. The durability of waste glass was found to be directly proportional to the quantity and basicity of the oxides of tetrahedrally coordinated network forming ions.

REYNOLDS JG

2011-07-27

417

The Basis of James W. Fowler's Understanding of Faith in the Research of Wilfred Cantwell Smith: An Examination from an Evangelical Perspective  

ERIC Educational Resources Information Center

This article focuses on the influence of Wilfred Cantwell Smith's presentation of the nature of faith on James W. Fowler's faith-development paradigm. Smith contended that, in the pre-modern era, terms translated by the English words "faith" and "believe" denoted a personal allegiance that did not require assent to any objective assertions. Two…

Jones, Timothy Paul

2004-01-01

418

Balancing Human and Environmental Needs with Increasingly Scarce Water Resources Mark Smith Director, Eastern U.S. Freshwater Program, The Nature Conservancy, Boston, MA  

Microsoft Academic Search

Mark Smith began his presentation describing current United States water management policies that affect the entire country. The first policy he addressed was the U.S. Clean Water Act, which was put into effect in 1972 and has been amended several times since. According to Smith, the Clean Water Act states that all water within the Unites States should be both

Christopher Krupenye

419

RELAÇÃO PESO\\/LARGURA, FATOR DE CONDIÇÃO E TAMANHO DE PRIMEIRA MATURAÇÃO DE Callinectes danae SMITH, 1869 (CRUSTACEA, PORTUNIDAE) NO MANGUEZAL DO ITACORUBI, SC, BRAZIL  

Microsoft Academic Search

WEIGHT\\/ WIDTH RELATIONSHIP, CONDITION FACTOR AND THE SIZE OF THE FIRST SEXUAL MATURATION OF Callinectes danae SMITH, 1869 (CRUSTACEA, PORTUNIDAE) OF THE ITACORUBI MANGROVE, SC, BRAZIL. Young and adults of Callinectes danae SMITH, 1869 (Crustacea, Portunidae) were collected from January 1988 to May 1989 in the Itacorubi mangrove, SC, Brazil, in order to take information about weight\\/width relationship, condition factor

Joaquim Olinto Branco; Adriana Thives

420

Drainage Area-Dependent Knickpoint Generation Mechanisms, Smith River, northern California  

NASA Astrophysics Data System (ADS)

Knickpoints and knickzones (reaches of relatively high gradient located immediately downstream of a knickpoint) are a prominent characteristic of the channel slopes of both mainstem and tributary channels of the 1,575 km2 Smith River drainage in northern California. We have investigated these knickpoints using aerial photos, 10 m and 1 m digital elevation models (DEM's), and NAIP images supplemented by Schmidt hammer rock strength measurements and field verification of channel and terrace elevations using real time kinematic GPS surveys. Two types of knickpoints occur. At higher drainage areas (threshold of greater than ~250 km2), knickpoints occur within rock types with no significant difference in rock strength. There is a distinct upstream convergence of the modern channel with the lowest elevated strath surface along these knickzones, resulting in elevated strath surfaces downstream of the knickzones. We infer that the knickpoints are transient and that the straths are more vertically separated from the modern channel only after the knickpoint has migrated upstream. The causative baselevel fall that generates migrating knickpoints in the Smith River may be eustatic sea level fall following Quaternary highstands. For instance, fluvial terraces are cut into stage 5 marine terraces at the coast and these fluvial terraces likely are generated in the wake of knickpoints migrating upstream. In contrast, at drainage areas less than ~250 km2, the only knickpoints present in channels are those associated with large landslides that mobilize entire hillslopes into the channel, forcing a channel response. Notably absent along the Smith River are any knickpoints associated with changes in rock strength, as measured by Schmidt hammer values. From these observations, we infer that, first, major knickpoints along channels above a threshold drainage area of about 250 km2 are generated by baselevel fall that propagates upstream through channels of varying rock type; and second, that knickpoints in upper drainage area positions (less than about 250 km2) are a response to hillslope instabilities that catastrophically deposit colluvium in channels creating a stationary knickpoint on geologic timescales.

Caldwell, D. J.; Kelsey, H. M.

2011-12-01

421

Rosiglitazone use and associated adverse event rates in Canada between 2004 and 2010  

PubMed Central

Background We examined the change in the use of rosiglitazone-containing products (RCPs) Canada-wide between 2004 and 2010 and whether the rates of adverse events in association with RCP therapy in Canadian patients changed in this period to better understand the real world use of RCP medications and as part of a regulatory commitment by GlaxoSmithKline to Health Canada to assess whether there was an impact of a risk communication on cardiac safety. Methods RCP utilization data were obtained from IMS Brogan’s longitudinal de-identified patient database (known as LRx) that tracks prescription activity using store-based data collection from pharmacies in all Canadian provinces. Adverse events (AEs), serious adverse events (SAEs) and cardiac AEs associated with RCP use in Canadian patients between April 2004 and December 2010 were identified from GlaxoSmithKline’s AE database and, using the LRx data, rates per 100,000 patients were estimated. Results A total of 239,184 patients were identified as having received at least one RCP prescription between 2004 and 2010 from the LRx. After excluding those with inconsistent gender or age, only one RCP prescription at the pharmacy, a prescription from a pharmacy that had not consistently reported for the past six years or an unreasonably high number of prescriptions, 180,936 patients remained for the analysis. The number of reports identified from the AE database that occurred between April 2004 and December 2010 was 1,037. The average monthly rates of AEs, SAEs and cardiac AEs decreased by 57%, 43% and 4%, respectively, between the observed periods, April 2004-October 2007 and November 2007-December 2010. Conclusions The findings of this analysis demonstrate a significant decrease in RCP use in Canada following a meta-analysis publication suggesting harm, which has been maintained. It is not possible to disentangle whether the continuing decline can be attributed to the meta-analysis, the changes in prescribing guidelines, media attention or a combination of some or all of these factors.

2013-01-01

422

Immunogenicity of HBV vaccine during stated shelf-life.  

PubMed

Thiomersal has been used as preservative in multi-dose vials of hepatitis B vaccine (Engerix-B). Due to safety concerns, thiomersal was replaced with 2-phenoxyethanol (2PE) as preservative in multi-dose vials. The potency of 2PE preserved hepatitis B vaccine multiple use vials was measured over the shelf-life in terms of immunogenicity, reactogenicity and safety. This single-blind, randomized study was conducted with the assistance of employees of GlaxoSmithKline Biologicals, makers of the Engerix-B vaccine. Four hundred twenty subjects aged > or =18 years were randomized to receive three doses (0, 1, 6 months) of 2PE preserved hepatitis B vaccine kept on the shelf <12 months (2PE New group), 2PE preserved hepatitis B vaccine kept on the shelf >18 months (2PE Old group), or thiomersal preserved hepatitis B vaccine [HBV(Thio) group]. Anti-HBs was measured by GlaxoSmithKline Biologicals post-vaccination; the reactogenicity and safety of the vaccines were assessed. Protective anti-HBs levels (> or =10 mIU/ml) were measured one month after dose 3. The results showed protective levels in 86.8% (2PE New), 89% (2PE Old) and 95.3% [HBV(Thio)]. There was no difference detected between the 2PE New and 2PE Old groups in terms of anti-HBs seroprotection rates and geometric mean concentrations one month after dose 3. However, both 2PE groups had significantly lower seroprotection rates than the HBV(Thio) group and the number of non-responders was higher in the 2PE groups than in the Thio group. A antibody response rates over time were similar between the 2PE New and Old groups. The reactogenicity profiles were acceptable and the ranges were similar for each group. The shelf-life of the vaccines had no impact on immunogenicity or reactogenicity and 2PE preserved hepatitis B vaccine can be considered stable over time. PMID:21073062

Gloriani, Nina G; Srinivasa, Karthik; Bock, Hans L; Hoet, Bernard

2010-07-01

423

Reflections on a Proposed Theory of Reservation-Dwelling American Indian Alcohol Use: Comment on Spillane and Smith (2007)  

Microsoft Academic Search

In their recent article, N. Spillane and G. Smith (2007) suggested that reservation-dwelling American Indians have higher rates of problem drinking than do either non–American Indians or those American Indians living in nonreservation settings. These authors further argued that problematic alcohol use patterns in reservation communities are due to the lack of contingencies between drinking and \\

Janette Beals; Annie Belcourt-Dittloff; Stacey Freedenthal; Carol Kaufman; Christina Mitchell; Nancy Whitesell; Karen Albright; Fred Beauvais; Gordon Belcourt; Bonnie Duran; Candace Fleming; Natasha Floersch; Kevin Foley; Lori Jervis; Billie Jo Kipp; Patricia Mail; Spero Manson; Philip May; Gerald Mohatt; Bradley Morse; Douglas Novins; Joan OConnell; Tassy Parker; Gilbert Quintero; Paul Spicer; Arlene Stiffman; Joseph Stone; Joseph Trimble; Kamilla Venner; Karina Walters

2009-01-01

424

Distribution, Nesting Sites and Nest Structures of the Stingless Bee Species, Trigona collina Smith, 1857 (Apidae, Meliponinae) in Thailand  

Microsoft Academic Search

The stingless bee species, Trigona collina Smith, 1857 is distributed throughout Thailand. From 640 colonies collected, nests were only found in the altitude range of 18 to 830 meters above sea level. Most nests were found in mixed deciduous forests at an altitude of less than 400 meters above sea level. Nesting sites can be conveniently divided into 4 main

TOUCHKANIN JONGJITVIMOL; WANDEE WATTANACHAIYINGCHAROEN

425

Adjustment Needed for Helley-Smith Bedload Samples Collected at low Transport Rates on Coarse Gravel Beds  

Microsoft Academic Search

River restoration frequently requires measurements of bedload transport as part of a site specific rating curve or as input for model calibration. A Helley-Smith type (HS) sampler is commonly used for these measurements, but it can have biased results. Several studies have shown that HS samplers deployed directly on a coarse gravel bed interact with the bed sediment. The interaction

K. Bunte; K. W. Swingle; S. R. Abt

2007-01-01

426

What's All the Noise? Differentiating Dimensions of Acoustic Stress and the Limits to Meta-Analysis: Reply to Smith (2012)  

ERIC Educational Resources Information Center

|Smith (2012) has provided pertinent observations on our recently published meta-analytic review (Szalma & Hancock, 2011) of the effects of acoustic noise on performance. His main points are as follows: (a) our review excluded some areas of research; (b) there were conceptual problems with our moderator analyses; and (c) limitations to…

Szalma, J. L.; Hancock, P. A.

2012-01-01

427

A Multifaceted Social Norms Approach To Reduce High-Risk Drinking: Lessons from Hobart and Williams Smith Colleges.  

ERIC Educational Resources Information Center

The Hobart and William Smith Colleges Alcohol Education Project (HWS) began in 1996 to test the social norms approach to reducing alcohol use by students. A social norms approach works on the premise that misperceived norms, perceptions that usually exaggerate what is typical for other students, lead to increased drinking as students attempt to…

Perkins, H. Wesley; Craig, David W.

428

Health Hazard Evaluation Report No. HHE-79-104-838, A.O. Smith-Inland, Inc., Little Rock, Arkansas.  

National Technical Information Service (NTIS)

In May 1979, the National Institute for Occupational Safety and Health (NIOSH) received a request from A.O. Smith-Inland, Inc., Little Rock, AR., to evaluate possible hazards to their Plant No. 2 employees from exposures to styrene, epichlorohydrin, dimet...

H. L. Markel T. Wilcox

1981-01-01

429

Reflections on a Proposed Theory of Reservation-Dwelling American Indian Alcohol Use: Comment on Spillane and Smith (2007)  

ERIC Educational Resources Information Center

|In their recent article, N. Spillane and G. Smith suggested that reservation-dwelling American Indians have higher rates of problem drinking than do either non-American Indians or those American Indians living in nonreservation settings. These authors further argued that problematic alcohol use patterns in reservation communities are due to the…

Beals, Janette; Belcourt-Dittloff, Annie; Freedenthal, Stacey; Kaufman, Carol; Mitchell, Christina; Whitesell, Nancy; Albright, Karen; Beauvais, Fred; Belcourt, Gordon; Duran, Bonnie; Fleming, Candace; Floersch, Natasha; Foley, Kevin; Jervis, Lori; Kipp, Billie Jo; Mail, Patricia; Manson, Spero; May, Philip; Mohatt, Gerald; Morse, Bradley; Novins, Douglas; O'Connell, Joan; Parker, Tassy; Quintero, Gilbert; Spicer, Paul; Stiffman, Arlene; Stone, Joseph; Trimble, Joseph; Venner, Kamilla; Walters, Karina

2009-01-01

430

Play-by-Play: Radio, Television, and Big-Time College Sport. By Ronald A. Smith. Baltimore  

Microsoft Academic Search

Ronald A. Smith, professor emeritus of Kinesiology at Penn State University, has written several books on the history of college sports, most notably, Sports and Freedom: The Rise of Big-Time College Athletics (New York: Oxford University Press, 1988). This book dealt with the development of American intercollegiate athletics from crew races in the middle of the nineteenth century until the

Stanley L. Engerman

2002-01-01

431

"And This Is How You Shall Ask": Linguistics, Anthropology, and Education in the Work of David Smith  

ERIC Educational Resources Information Center

|This article celebrates the life and work of David M. Smith, former Council on Anthropology and Education president and founder of the University of Pennsylvania Ethnography in Education Research Forum, tracing his contributions to the fields of linguistics, anthropology, and education through the dual lens of his ten research principles and Walt…

Gilmore, Perry; McDermott, Ray

2006-01-01

432

Siblings of Individuals with Smith-Magenis Syndrome: An Investigation of the Correlates of Positive and Negative Behavioural Traits  

ERIC Educational Resources Information Center

Background: Smith-Magenis syndrome (SMS) is a neurodevelopmental disorder that affects approximately one out of 25 000 births worldwide. To date, no research has been conducted to investigate how having an individual with SMS in a family is a positive or negative influence on siblings. Methods: To investigate this question we conducted a study…

Moshier, M. S.; York, T. P.; Silberg, J. L.; Elsea, S. H.

2012-01-01

433

An Indirect Examination of the Function of Problem Behavior Associated with Fragile X Syndrome and Smith-Magenis Syndrome  

ERIC Educational Resources Information Center

Fragile X syndrome (FXS) and Smith-Magenis syndrome (SMS) are associated with a number of specific topographies of problem behavior. Very few studies have examined the function served by problem behavior in these groups. Using the Questions About Behavioral Function scale Matson and Vollmer (User's guide: questions about behavioral function…

Langthorne, Paul; McGill, Peter

2012-01-01

434

Sensory Motor and Functional Skills of Dizygotic Twins: One with Smith-Magenis Syndrome and a Twin Control  

ERIC Educational Resources Information Center

|Smith-Magenis syndrome (SMS), the result of an interstitial deletion within chromosome 17p11.2, is a disorder that may include minor dysmorphic features, brachydactyly, short stature, hypotonia, speech delays, cognitive deficits, signs of peripheral neuropathy, scoliosis, and neurobehavioral problems including sleep disturbances and maladaptive…

Smith, Michaele R.; Hildenbrand, Hanna; Smith, Ann C. M.

2009-01-01

435

Summer sound-level characterization of the Deaf Smith County and Swisher County locations in the Palo Duro Basin, Texas  

SciTech Connect

A description of sound levels and sound sources in the Deaf Smith County and Swisher County locations in the Palo Duro Basin during a period representative of the summer season is presented. Included are data collected during the period August 4 through 8, 1982, for both locations. 3 references, 2 figures, 3 tables.

Not Available

1984-03-01

436

Winter sound-level characterization of the Deaf Smith County location in the Palo Duro Basin, Texas  

SciTech Connect

A description of sound levels and sound sources in the Deaf Smith County location in the Palo Duro Basin during a period representative of the winter season is presented. Data were collected during the period February 26 through March 1, 1983. 4 references, 1 figure, 3 tables.

Not Available

1984-03-01

437

DNA Evidence in Rape Cases and The Debbie Smith ActForensic Practice and Criminal Justice Implications  

Microsoft Academic Search

The Debbie Smith or “Justice for All” Act was passed on November 1, 2004. The act addresses the problem of collecting and analyzing DNA evidence from backlogged rape kits sitting in crime laboratories around the country. Presently, no empirical data exist by which to assess the soundness of the legislation. However, the act clearly affects discrete operations within the forensic

Terhi V. T. Telsavaara; Bruce A. Arrigo

2006-01-01

438

Effect of a Sewage Effluent Discharge on the Deposition of Calcium Carbonate on Shells of the Snail Potamopyrgus jenkinsi (Smith)  

Microsoft Academic Search

DURING an ecological survey of the River Ivel1, a chalk stream in Bedfordshire, it was observed that shells of the snail Potamopyrgus jenkinsi (Smith) were heavily encrusted with calcareous nodules upstream of a sewage effluent discharge whereas downstream of the discharge such shells were clean (Fig. 1). Above the sewage effluent, snails were more than 70 per cent heavier than

R. W. Edwards

1960-01-01

439

Displaced dorsal metaphyseal cortex associated with delayed extensor pollicis longus tendon entrapment in a pediatric Smith's fracture.  

PubMed

Extensor pollicis longus (EPL) tendon entrapment has been rarely reported as a complication of closed treatment of a pediatric Smith's type distal radius fractures. This article presents the unique case of an initially functional EPL tendon that became entrapped in fracture callus in a 9-year-old boy, the youngest reported in the literature. PMID:23628574

Mansour, Alfred A; Watson, Jeffry T; Martus, Jeffrey E

2013-01-01

440

A Multifaceted Social Norms Approach To Reduce High-Risk Drinking: Lessons from Hobart and Williams Smith Colleges.  

ERIC Educational Resources Information Center

|The Hobart and William Smith Colleges Alcohol Education Project (HWS) began in 1996 to test the social norms approach to reducing alcohol use by students. A social norms approach works on the premise that misperceived norms, perceptions that usually exaggerate what is typical for other students, lead to increased drinking as students attempt to…

Perkins, H. Wesley; Craig, David W.

441

Treatment of Violent Juvenile Offenders—We Have the Knowledge: Comment on Gorman-Smith et al. (1996)  

Microsoft Academic Search

On the basis of research by D. Gorman-Smith, P. H. Tolan, A. Zelli, and L. R. Huesmann (1996) and many others, a reasonable consensus has been achieved regarding the concurrent correlates of criminal behavior in adolescents. Moreover, it is known that when these correlates are addressed through a well-specified, ecological treatment model that emphasizes the delivery of flexible, individualized, and

Scott W. Henggeler

1996-01-01

442

Hallazgo de Masoniella grisea G. Smith en el suelo de gallineros y comprobación de su patogenidad para animales de laboratorio  

Microsoft Academic Search

Resumen 1. En el curso del chequeo seriado de muestras de suelo de gallineros, recogidas en el Edo. Mérida\\/Venezuela y sus alrededores en búsqueda deHistoplasma capsulatum, se desarrolló en los cultivos de hígado y bazo de los ratones en más del 25 % de los casos un hongo perteneciente a la especieMasoniella griseaG. Smith.

C. Capretti; K. Salfelder

1961-01-01

443

Comment on ‘Effects of channel enlargement by river ice processes on bankfull discharge in Alberta, Canada’ by D. G. Smith  

Microsoft Academic Search

The fact that return periods for bankfull flow in Albertan rivers appear to be considerably longer than in most other rivers for which data have been reported is indisputable. Smith's definition of 'bankfull' and his survey procedure for establishing the bankfull stage height also appear to be reasonably consistent with earlier work and should have no special effect on the

Rolf Kellerhals; Michael Church

1980-01-01

444

An efficient implementation of Smith Waterman algorithm on GPU using CUDA, for massively parallel scanning of sequence databases  

Microsoft Academic Search

The Smith Waterman algorithm for sequence alignment is one of the main tools of bioinformatics. It is used for sequence similarity searches and alignment of similar sequences. The high end Graphical Processing Unit (GPU), used for processing graphics on desktop computers, deliver computational capabilities exceeding those of CPUs by an order of magnitude. Recently these capabilities became a ccessible for

Lukasz Ligowski; Witold Rudnicki

2009-01-01

445

ECOLOGY, BEHAVIOR AND BIONOMICS Análise Polínica do Resíduo Pós-Emergência de Ninhos de Centris tarsata Smith (Hymenoptera: Apidae, Centridini)  

Microsoft Academic Search

A new treatment protocol was developed to analyze pollen residues found in nests of Centris tarsata Smith harvested from nest-traps. The study area was located in the Canudos Biological Station in the municipality of Canudos (09º56'34\\

MARCOS DA C DÓREA; FRANCISCO DE A R DOS SANTOS; L E LIMA; LUÍS E R FIGUEROA

446

78 FR 17871 - Changes To Implement the Technical Corrections to the Leahy-Smith America Invents Act as to Inter...  

Federal Register 2010, 2011, 2012, 2013

...0651-AC83 Changes To Implement the Technical Corrections to the Leahy-Smith America Invents...United States Code (``AIA Technical Corrections Act''). Consistent with the statutory...Purpose: The purpose of the AIA Technical Corrections Act is to correct and improve...

2013-03-25

447

Greenhouse Gas Emissions at Smith College: A Comprehensive Inventory from 1990-2004 and Suggestions for Future Emissions Reductions  

Microsoft Academic Search

Anthropogenic emissions of greenhouse gases are known to be causing an increase in atmospheric greenhouse gas concentrations well above natural levels. This drastic increase may be causing global warming that is resulting in worldwide climate change. As part of an agreement with Clean Air-Cool Planet, whose mission is to address the issue of global warming, Smith College conducted a greenhouse

Elizabeth Thomas

448

Correlation of severity and outcome with plasma sterol levels in variants of the Smith-Lemli-Opitz syndrome  

Microsoft Academic Search

Objectives: To determine whether type I and the more severe type II variant of Smith-Lemli-Opitz syndrome have the same metabolic defect and to learn which plasma sterol measurements best predict survival. Methods: Plasma sterols were measured in 33 individuals (24 type I, 9 type II) with a clinical diagnosis of the syndrome. Results: Cholesterol levels were abnormally low (61 ±

G. S. Tint; Gerald Salen; Ashok K. Batta; Sarah Shefer; Mira Irons; Ellen Roy Elias; Dianne N. Abuelo; Virginia P. Johnson; Marie Lambert; Richard Lutz; Carolyn Schanen; Colleen A. Morris; George Hoganson; Rhiannon Hughes-Benzie

1995-01-01

449

77 FR 43742 - Changes To Implement the First Inventor To File Provisions of the Leahy-Smith America Invents Act  

Federal Register 2010, 2011, 2012, 2013

...Changes To Implement the First Inventor To File Provisions of the Leahy-Smith America...invent'' system to a ``first inventor to file'' system; treats United States patents...invent'' system to a ``first inventor to file'' system; (2) treat U.S....

2012-07-26

450

Observation of Frequency-Locked Coherent Terahertz Smith-Purcell Radiation  

NASA Astrophysics Data System (ADS)

We report the observation of enhanced coherent Smith-Purcell radiation (SPR) at terahertz (THz) frequencies from a train of picosecond bunches of 15 MeV electrons passing above a grating. SPR is more intense than other sources, such as transition radiation, by a factor of Ng, the number of grating periods. For electron bunches that are short compared with the radiation wavelength, coherent emission occurs, enhanced by a factor of Ne, the number of electrons in the bunch. The electron beam consists of a train of Nb bunches, giving an energy density spectrum restricted to harmonics of the 17 GHz bunch train frequency, with an increased energy density at these frequencies by a factor of Nb. We report the first observation of SPR displaying all three of these enhancements, NgNeNb. This powerful SPR THz radiation can be detected with a high signal to noise ratio by a heterodyne receiver.

Korbly, S. E.; Kesar, A. S.; Sirigiri, J. R.; Temkin, R. J.

2005-02-01

451

Coherent Smith-Purcell radiation as a diagnostic for sub-picosecond electron bunch length  

SciTech Connect

We suggest a novel technique of measuring sub-picosecond electron bunch length base on coherent Smith-Purcell radiation (SPR) emitted when electrons pass close to the surface of a metal grating. With electron bunch lengths comparable to the grating period, we predict that coherent SPR will be emitted at large angles with respect to direction of beam propagation. As the bunch length shortens, the coherent SPR will be enhanced over the incoherent component that is normally observed at small angles. Furthermore, the angular distribution of the coherent SPR will be shifted toward smaller angles as the bunch length becomes much smaller than the grating period. By measuring the angular distribution of the coherent SPR, one can determine the bunch length of sub-picosecond electron pulses. This new technique is easy to implement and appears capable of measuring femtosecond electron bunch lengths.

Nguyen, D.C.

1996-10-01

452

Cultural resources: Deaf Smith and Swisher County locations, Palo Duro Basin, Texas  

SciTech Connect

Cultural resources are prehistoric and historic sites, including archeological and paleontological sites, that are important to a group of people. They are protected by both federal and state legislation. In the area covered by the Deaf Smith and Swisher County locations, four stages of cultural development have been identified: Paleo-Indian, Archaic, Ceramic (Neo-Indian or Neo-American), and Historic. Areas where undiscovered cultural resources are most likely to be found include sources of water, playa lakes, and historic trails. Because extensive surveying has not been done in either location, the number of identified sites is low. However, the potential for finding undiscovered sites is high for significant parts of both locations.

Not Available

1984-12-01

453

Ground-water conditions in the Triassic aquifer in Deaf Smith and Swisher Counties  

SciTech Connect

In April 1984, the Director of the Nuclear Waste Programs of the Governor's Office requested a study be undertaken by the Texas Department of Water Resources on the ground-water conditions in the Triassic aquifer in Deaf Smith and Swisher Counties. The need for the study was prompted by the U.S. Department of Energy's (DOE) announcement that consideration was being given to locating high-level nuclear waste repository sites in these counties and by the concern over what impacts operation of such sites might have on the ground-water resources in the area. The results of the study, including a discussion of the occurrence of ground water and a tabulation of basic data obtained during the investigation are presented in this report.

Duffin, G.L.

1984-12-01

454

Visual assessments for Swisher County and Deaf Smith County locations, Palo Duro Basin, Texas  

SciTech Connect

The area of the Swisher and Deaf Smith County locations is characterized by vast open spaces with limited vertical relief and vegetative cover. The stream valleys and areas around the playa lakes provide the only significant topographical relief in either location, and the areas in range vegetation provide the only major contrast to the dominant land cover of agricultural crops. Tree stands occur almost exclusively in association with orchards, country clubs, farmsteads, and urban areas. Because of climatic conditions in the region, there are few permanent water bodies in either location. Grain elevators, farmsteads, and other cultural modifications (roads, utility lines, fence rows, etc.) are scattered throughout both locations, but they constitute a very small portion of the visible landscape. These features help provide scale in the landscape and also serve as visual landmarks.

Not Available

1984-12-01

455

Evaluation of air quality and noise impact assessments, Deaf Smith County  

SciTech Connect

In this report, several issues are identified regarding the air quality and noise impact assessments presented in the final salt repository environmental assessment (EA) prepared by the US Department of Energy for the Deaf Smith County, Texas, site. Necessary revisions to the data and methods used to develop the EA impact assessment are described. Then, a comparative evaluation is presented in which estimated impacts based upon the revised data and methods are compared with the impacts published in the EA. The evaluation indicates that the conclusions of the EA air quality and noise impacts sections would be unchanged. Consequently, the guideline findings presented in Chapter 6 of the EA are also unchanged by the revised analysis. 13 tabs.

Not Available

1986-05-01

456

Site Study Plan for laboratory soil mechanics, Deaf Smith County site, Texas: Revision 1  

SciTech Connect

This Site Study Plan for laboratory soil mechanics describes the laboratory testing to be conducted on soil samples collected as part of the characterization of the Deaf Smith County site, Texas. This study provides for measurements of index, mechanical, thermal, hydrologic, chemical, and mineral properties of soils from boring throughout the site. Samples will be taken from Playa Borings/Trenching, Transportation/Utilities Foundation Borings, Repository Surface Facilities Design Foundation Borings, and Exploratory Shaft Facilities Design Foundation Borings. Data from the laboratory tests will be used for soil strata characterization, design of foundations for surface structures, design of transportation facilities and utility structures, design of impoundments, design of shaft lining, design of the shaft freeze wall, shaft permitting, performance assessment calculations, and other program requirements. A tentative testing schedule and milestone log are given. A quality assurance program will be utilized to assure that activities affecting quality are performed correctly and that appropriate documentation is maintained. 18 refs., 6 figs., 3 tabs.

Not Available

1987-12-01

457

Site study plan for Playa investigations, Deaf Smith County, Texas: Salt Repository Project  

SciTech Connect

This plan defines the purpose and objectives of the Playa Investigation Study, presents a plan of work to provide the information necessary to resolve issues, and discusses the rationale for test method selection. The required information will be obtained from existing well drilling records, describing and testing of soil and rock samples recovered from project test holes, geophysical well logs, seismic surveys, and shallow test pits excavated at ground surface. There have been numerous, often conflicting, theories presented to explain the origin(s) of the playas of the Texas High Plains. The primary purpose of this study is to establish if existing playas and playa alignments are related to deeper subsurface structure, such as faulting or salt dissolution, the potential for future playa development, and the significance of existing and/or future playas on siting a repository in Deaf Smith County, Texas. 11 refs.

Not Available

1987-04-02

458

[Linkage analysis and mutation detection of GRIA3 in Smith--Fineman--Myers syndrome].  

PubMed

To determine the role of GRIA3 in the etiology of Smith--Fineman--Myers syndrome (SFMS), polymorphic short tandem repeats within GRIA3 gene were genotyped by PCR and denaturing polyacrylamide gel electrophoresis to test linkage between GRIA3 and the gene responsible for SFMS. The open reading frame of GRIA3 was detected for mutation by PCR amplification and direct sequencing in affected and normal males from SFMS family. One of the two short tandem repeats was informative in SFMS family. Tight linkage between SFMS locus and GRIA3 gene was established by STR3 within GRIA3 gene. No disease--causing mutation was found within the open reading frame of GRIA3 gene. The disease in SFMS family from Shandong (China) is not caused by the mutation within open reading frame of GRIA3 gene. PMID:11725645

Liu, Q J; Gong, Y Q; Chen, B X; Guo, C H; Li, J X; Guo, Y S

2001-11-01

459

Taxonomic studies on the ant genus Cerapachys Smith (Hymenoptera, Formicidae) from India.  

PubMed

The Indianspeciesof the ant genus Cerapachys Smith are keyed. Twelve species are recognized of which 6 are described as new. The species are: Cerapachys aitkenii Forel, Cerapachys alii sp. n., Cerapachys anokha sp. n., Cerapachys besucheti Brown, Cerapachys biroi Forel, Cerapachys indicus Brown, Cerapachys longitarsus (Mayr), Cerapachys nayana sp. n., Cerapachys schoedli sp. n., Cerapachys seema sp. n., Cerapachys sulcinodis Emery and Cerapachys wighti sp. n. Geographic distribution and group affinities of the new species are discussed. A revised key to the Indian species is provided. The rare ergatoid queens of Cerapachys nayana, Cerapachys schoedli and Cerapachys seema are reported. Formed in response to selective pressures these ergatoid queens have a significant role in dispersal strategies and contribute much to our understanding of the biology of these ants. PMID:24146574

Bharti, Himender; Akbar, Shahid Ali

2013-09-27

460

Electron Bunch Profile Diagnostics in the Few FS Regime Using Coherent Smith-Purcell Radiation  

SciTech Connect

The rapid developments in the field of laser-driven particle acceleration hold the prospect of intense, highly relativistic electron bunches that are only a few fs long. The determination of the temporal profile of such bunches presents new challenges. The use of a radiative process such as Smith-Purcell radiation (SPR), is particularly promising in this respect. In this technique the beam is made to radiate a small amount of e/m radiation and the temporal profile is reconstructed from the measured spectral distribution of the radiation. We summarise the advantages of SPR and present the design parameters and preliminary results of the experiments at the FACET facility at SLAC. We also discuss a new approach to the problem of the recovery of the 'missing phase', which is essential for the accurate reconstruction of the temporal bunch profile.

Bartolini, R.; /Oxford U. /Diamond Light Source; Clarke, C.; /SLAC; Delerue, N.; /Orsay, LAL; Doucas, G.; Pattle, K.; Perry, C.; Reichold, A.; Tovey, R.; /Oxford U.

2011-12-13

461

Taxonomic studies on the ant genus Cerapachys Smith (Hymenoptera, Formicidae) from India  

PubMed Central

Abstract The Indianspeciesof the ant genus Cerapachys Smith are keyed. Twelve species are recognized of which 6 are described as new. The species are: Cerapachys aitkenii Forel, Cerapachys alii sp. n., Cerapachys anokha sp. n., Cerapachys besucheti Brown, Cerapachys biroi Forel, Cerapachys indicus Brown, Cerapachys longitarsus (Mayr), Cerapachys nayana sp. n., Cerapachys schoedli sp. n., Cerapachys seema sp. n., Cerapachys sulcinodis Emery and Cerapachys wighti sp. n. Geographic distribution and group affinities of the new species are discussed. A revised key to the Indian species is provided. The rare ergatoid queens of Cerapachys nayana, Cerapachys schoedli and Cerapachys seema are reported. Formed in response to selective pressures these ergatoid queens have a significant role in dispersal strategies and contribute much to our understanding of the biology of these ants.

Bharti, Himender; Akbar, Shahid Ali

2013-01-01

462

Enhancement of Smith—Purcell radiation with surface-plasmon excitation  

NASA Astrophysics Data System (ADS)

With the aid of a three-dimensional particle-in-cell code simulation, the enhancement of Smith—Purcell radiation with a surface-plasmon mode excited by a single electron bunch and by a premodulated electron beam is considered in the paper. In the simulation, the model is a grating covered by Ag film. The results demonstrate that when the surface-plasmon mode is excited by a single electron bunch, the maximum radiation occurs at an observation angle depending on the surface-plasmon frequency, and the radiation power can be enhanced more than ten times. And for pre-bunched electron beam excitation, when one of the harmonics of the bunching frequency is resonant with that of the surface-plasmon mode, the radiation power is twenty times more than that from a perfectly conducting grating excited by the same premodulated electron beam.

Zhang, Ping; Zhang, Ya-Xin; Zhou, Jun; Liu, Wei-Hao; Zhong, Ren-Bin; Liu, Sheng-Gang

2012-10-01

463

Three-dimensional theory of the Smith-Purcell free-electron laser with side walls  

SciTech Connect

We present an analytic theory for the operation of a Smith-Purcell free-electron laser with side walls that includes the effects of transverse diffraction in the optical beam. We allow the width of the electron beam and the width of the grating to vary independently and require the walls to be high compared to the wavelength of the evanescent wave. The results show that the side walls change the empty-grating dispersion relation in important ways. When the separation of the walls is not too large, it is sufficient to consider only the lowest-order transverse mode of the grating. In this case, we obtain excellent agreement with numerical simulations and experimental results.

Andrews, H. L.; Jarvis, J. D.; Brau, C. A. [Department of Physics and Astronomy, Vanderbilt University, Nashville, Tennessee 37235 (United States)

2009-01-15

464

Electron Bunch Profile Reconstruction in the Few fs Regime using Coherent Smith-Purcell Radiation  

SciTech Connect

Advanced accelerators for fourth generation light sources based on high brightness linacs or laser-driven wakefield accelerators will operate with intense, highly relativistic electron bunches that are only a few fs long. Diagnostic techniques for the determination of temporal profile of such bunches are required to be non invasive, single shot, economic and with the required resolution in the fs regime. The use of a radiative process such as coherent Smith-Purcell radiation (SPR), is particularly promising with this respect. In this technique the beam is made to radiate a small amount of electromagnetic radiation and the temporal profile is reconstructed from the measured spectral distribution of the radiation. We summarise the advantages of SPR and present the design parameters and preliminary results of the experiments at the FACET facility at SLAC. We also discuss a new approach to the problem of the recovery of the 'missing phase', which is essential for the accurate reconstruction of the temporal bunch profile.

Bartolini, R.; /Oxford U., JAI /Diamond Light Source /SLAC; Clarke, C.; /SLAC; Delerue, N; /Oxford U., JAI /Diamond Light Source /SLAC; Doucas, G; Reichold, A; /Oxford U., JAI

2012-06-20

465

Haploinsufficiency of cytosolic serine hydroxymethyltransferase in the Smith-Magenis syndrome.  

PubMed Central

Folate-dependent one-carbon metabolism is critical for the synthesis of numerous cellular constituents required for cell growth, and serine hydroxymethyltransferase (SHMT) is central to this process. Our studies reveal that the gene for cytosolic SHMT (cSHMT) maps to the critical interval for Smith-Magenis syndrome (SMS) on chromosome 17p11.2. The basic organization of the cSHMT locus on chromosome 17 was determined and was found to be deleted in all 26 SMS patients examined by PCR, FISH, and/or Southern analysis. Furthermore, with respect to haploinsufficiency, cSHMT enzyme activity in patient lymphoblasts was determined to be approximately 50% that of unaffected parent lymphoblasts. Serine, glycine, and folate levels were also assessed in three SMS patients and were found to be within normal ranges. The possible effects of cSHMT hemizygosity on the SMS phenotype are discussed. Images Figure 1 Figure 2 Figure 3

Elsea, S H; Juyal, R C; Jiralerspong, S; Finucane, B M; Pandolfo, M; Greenberg, F; Baldini, A; Stover, P; Patel, P I

1995-01-01

466

Impact assessment report: R. Paul Smith Steam Electric Station aquatic monitoring program. Volume I. Text  

SciTech Connect

This document is a summary and interpretation of findings from aquatic monitoring studies that have been conducted since 1976 at the site of the R. Paul Smith Steam Electric Station on the upper Potomac River. The report gives an overview of all the studies, summarizes major findings, and presents conclusions about the impact of plant operations on the lotic ecosystem. More detailed descriptions of individual studies (e.g., methods, analyses, results) are presented in Appendices A through D (Volume II), wherein studies are grouped by similar topics: A -- physical and chemical variables, B -- periphyton, C -- benthic macroinvertebrates, and D -- finfish. These appendices include all study findings deemed relevant to the assessment of plant impact.

Janicki, A.J.; Johnson, G.F.; Summers, J.K.; Smith, R.P.; Ross, R.N.

1981-06-01

467

A novel RAB33B mutation in Smith-McCort dysplasia.  

PubMed

Smith-McCort dysplasia (SMC) is a rare autosomal recessive spondylo-epi-metaphyseal dysplasia with skeletal features identical to those of Dyggve-Melchior-Clausen syndrome (DMC) but with normal intelligence and no microcephaly. Although both syndromes were shown to result from mutations in the DYM gene, which encodes the Golgi protein DYMECLIN, a few SMC patients remained negative in DYM mutation screening. Recently, autozygosity mapping and exome sequencing in a large SMC family have allowed the identification of a missense mutation in RAB33B, another Golgi protein involved in retrograde transport of Golgi vesicles. Here, we report a novel RAB33B mutation in a second SMC case that leads to a marked reduction of the protein as shown by Western blot and immunofluorescence. These data confirm the genetic heterogeneity of SMC dysplasia and highlight the role of Golgi transport in the pathogenesis of SMC and DMC syndromes. PMID:23042644

Dupuis, Nina; Lebon, Sophie; Kumar, Manoj; Drunat, Séverine; Graul-Neumann, Luitgard M; Gressens, Pierre; El Ghouzzi, Vincent

2012-11-08

468

Adam Smith's invisible hand is unstable: physics and dynamics reasoning applied to economic theorizing  

NASA Astrophysics Data System (ADS)

Neo-classical economic theory is based on the postulated, nonempiric notion of utility. Neo-classical economists assume that prices, dynamics, and market equilibria are supposed to be derived from utility. The results are supposed to represent mathematically the stabilizing action of Adam Smith's invisible hand. In deterministic excess demand dynamics, however, a utility function generally does not exist mathematically due to nonintegrability. Price as a function of demand does not exist and all equilibria are unstable. Qualitatively, and empirically, the neo-classical prediction of price as a function of demand describes neither consumer nor trader demand. We also discuss five inconsistent definitions of equilibrium used in economics and finance, only one of which is correct, and then explain the fallacy in the economists' notion of `temporary price equilibria'.

McCauley, Joseph L.

2002-11-01

469

THE SMITH CLOUD: HIGH-VELOCITY ACCRETION AND DARK MATTER CONFINEMENT  

SciTech Connect

The Smith Cloud is a massive system of metal-poor neutral and ionized gas (M{sub gas} approx> 2 x 10{sup 6} M{sub sun}) that is presently moving at high velocity (V{sub GSR}approx 300 km s{sup -1}) with respect to the Galaxy at a distance of 12 kpc from the Sun. The kinematics of the cloud's cometary tail indicates that the gas is in the process of accretion onto the Galaxy, as first discussed by Lockman et al. Here, we re-investigate the cloud's orbit by considering the possibility that the cloud is confined by a dark matter halo. This is required for the cloud to survive its passage through the Galactic corona. We consider three possible models for the dark matter halo (Navarro-Frenk-White (NFW), Einasto, and Burkert) including the effects of tidal disruption and ram pressure stripping during the cloud's infall onto and passage through the Galactic disk. For the NFW and Einasto dark matter models, we are able to determine reasonable initial conditions for the Smith Cloud, although this is only marginally possible with the Burkert model. For all three models, the progenitor had an initial (gas+dark matter) mass that was an order-of-magnitude higher than inferred today. In agreement with Lockman et al., the cloud appears to have punched through the disk approx70 Myr ago. For our most successful models, the baryon-to-dark matter ratio is fairly constant during an orbital period but drops by a factor of 2-5 after transiting the disk. The cloud appears to have only marginally survived its transit and is unlikely to retain its integrity during the next transit approx 30 Myr from now.

Nichols, M.; Bland-Hawthorn, J., E-mail: m.nichols@physics.usyd.edu.a [Sydney Institute for Astronomy, School of Physics, University of Sydney, NSW 2006 (Australia)

2009-12-20

470

Technical procedures for the implementation of cultural resource site studies, Deaf Smith County, Texas: Preliminary draft  

SciTech Connect

Cultural resources at the Deaf Smith County site will be identified, evaluated and managed through the implementation of studies detailed in the Site Study Plan for Cultural Resources. This technical procedure outlines the conduct of pedestrian survey and the documentation of identified cultural resources. The purpose of the field surveys is to identify and document cultural resources in the areas that will be affected by site characterization activities and to record the environmental setting of identified cultural resources. Three pedestrian surveys will cover 100 percent of the on-site and off-site project areas. Survey 1 will provide coverage of the Repository Surface Facility (RSF) area, which includes the Exploratory Shaft Facility (ESF) and two linear engineering design borehole (EDBH) seismic survey corridors. Survey 2 will provide coverage of a 39 km/sup 2/ (15 mi/sup 2/) area that includes the 23 km/sup 2/ (9 mi/sup 2/) Deaf Smith County site plus a 0.4 to 0.8 kM (1/4 to 1/2 mi) border area but excludes the area covered by Survey 1. Survey 3 will cover offsite geotechnical test areas, such as the locations of playa boreholes, deep playa wells, hydrologic tests, site foundation borings, and their access routes. The purpose of site documentation or recording is to address the project information needs for land use permits and approvals, engineering design support, and cultural resource evaluation for National Register of Historic Places eligibility. Site documentation will consist of gathering sufficient data on identified resources to complete Texas Natural Resource Information System (TNRIS). 7 refs., 3 figs.

Not Available

1987-09-30

471

Final Report - Conservation & Renewable Energy Potential Study For Smith River Rancheria  

SciTech Connect

In January 2006 the Smith River Rancheria (SRR), located in Smith River, California, contracted with the team of Strategic Energy Solutions (SES) and Evergreen NRG to conduct a study for the community. The objective of the study was to identify renewable generation opportunities that would facilitate Rancheria energy independence through SRR owned and operated power projects. These generation facilities were to be located either on or near the reservation. Specifically, the Rancheria was interested in the viability of generating electric power using biomass and wind fuel resources. Initial research identified that a very small portion of the community's energy could be offset by renewable energy generation due to the low solar resource in this area, and the lack of significant wind or biomass resources on or near reservation land. Some larger projects were identified which offered little or no benefit to the Rancheria. As a result, the scope of this study was changed in October 2006 to focus on energy efficiency opportunities for key reservation facilities, with a continued analysis of smaller renewable energy opportunities within reservation boundaries. The consulting team initially performed a resource analysis for biomass and solar generation opportunities in the region of the Rancheria. It was quickly concluded that none of these options would yield renewable power for the Rancheria at costs competitive with current utility sources, and that any larger installations would require substantial funding that may not be available. Having made these conclusions early on, the study effort was redirected and the team investigated each of the major Rancheria buildings to look for solar, wind and conservation opportunities. The buildings were audited for energy use and the roof areas were examined for exposure of solar radiation. Wind resources were also investigated to determine if smaller wind turbines would offer power generation at a reasonable cost.

Greg Retzlaff

2007-07-01

472

The face of Smith-Magenis syndrome: a subjective and objective study  

PubMed Central

We report a study of 55 subjects with Smith-Magenis syndrome, aged 9 months to 35 years. Each person has been evaluated with an assessment of "gestalt" and detailed facial measurement, using previously published methodology, with compilation of Z score pattern profiles.?The facial phenotype of SMS is quite distinctive, even in the young child. The overall face shape is broad and square. The brows are heavy, with excessive lateral extension of the eyebrows. The eyes slant upwards and appear close set and deep set. The nose has a depressed root and, in the young child, a scooped bridge. With time, the bridge becomes more ski jump shaped. The height of the nose is markedly reduced while the nasal base is broad and the tip of the nose is full. The shape of the mouth and upper lip are most distinctive. The mouth is wide with full upper and lower lips. The central portion of the upper lip is fleshy and everted with bulky philtral pillars, producing a tented appearance that, in profile, is striking. With age, mandibular growth is greater than average and exceeds that of the maxilla. This leads to increased jaw width and protrusion and marked midface hypoplasia.?Craniofacial pattern analysis supports these subjective impressions. After mid-childhood, mandibular dimensions consistently exceed their maxillary counterparts. Craniofacial widths are greater than corresponding depths and heights. Nasal height is reduced while nasal width is increased. There is mild brachycephaly. The most marked age related changes are increased width of the nose and lower face (mandibular width) with reduction in nasal height and midfacial depth.???Keywords: Smith-Magenis syndrome; facial measurements

Allanson, J.; Greenberg, F.; Smith, A.

1999-01-01

473

The Smith Cloud: High-Velocity Accretion and Dark Matter Confinement  

NASA Astrophysics Data System (ADS)

The Smith Cloud is a massive system of metal-poor neutral and ionized gas (M gas gsim 2 × 106 M sun) that is presently moving at high velocity (V GSR? 300 km s-1) with respect to the Galaxy at a distance of 12 kpc from the Sun. The kinematics of the cloud's cometary tail indicates that the gas is in the process of accretion onto the Galaxy, as first discussed by Lockman et al. Here, we re-investigate the cloud's orbit by considering the possibility that the cloud is confined by a dark matter halo. This is required for the cloud to survive its passage through the Galactic corona. We consider three possible models for the dark matter halo (Navarro-Frenk-White (NFW), Einasto, and Burkert) including the effects of tidal disruption and ram pressure stripping during the cloud's infall onto and passage through the Galactic disk. For the NFW and Einasto dark matter models, we are able to determine reasonable initial conditions for the Smith Cloud, although this is only marginally possible with the Burkert model. For all three models, the progenitor had an initial (gas+dark matter) mass that was an order-of-magnitude higher than inferred today. In agreement with Lockman et al., the cloud appears to have punched through the disk ?70 Myr ago. For our most successful models, the baryon-to-dark matter ratio is fairly constant during an orbital period but drops by a factor of 2-5 after transiting the disk. The cloud appears to have only marginally survived its transit and is unlikely to retain its integrity during the next transit ? 30 Myr from now.

Nichols, M.; Bland-Hawthorn, J.

2009-12-01

474

Teleost fish osmoregulation: what have we learned since August Krogh, Homer Smith, and Ancel Keys  

NSDL National Science Digital Library

The August Krogh Distinguished Lectureship of the APS Comparative and Evolutionary Physiology Section, 2008. Teleost fish osmoregulation: what have we learned since August Krogh, Homer Smith, and Ancel Keys. Am J Physiol Regul Integr Comp Physiol 295: R704ÃÂ R713, 2008. First published June 4, 2008; doi:10.1152/ajpregu.90337.2008.ÃÂIn the 1930s, August Krogh, Homer Smith, and Ancel Keys knew that teleost fishes were hyperosmotic to fresh water and hyposmotic to seawater, and, therefore, they were potentially salt depleted and dehydrated, respectively. Their seminal studies demonstrated that freshwater teleosts extract NaCl from the environment, while marine teleosts ingest seawater, absorb intestinal water by absorbing NaCl, and excrete the excess salt via gill transport mechanisms. During the past 70 years, their research descendents have used chemical, radioisotopic, pharmacological, cellular, and molecular techniques to further characterize the gill transport mechanisms and begin to study the signaling molecules that modulate these processes. The cellular site for these transport pathways was first described by Keys and is now known as the mitochondrion-rich cell (MRC). The model for NaCl secretion by the marine MRC is well supported, but the model for NaCl uptake by freshwater MRC is more unsettled. Importantly, these ionic uptake mechanisms also appear to be expressed in the marine gill MRC, for acid-base regulation. A large suite of potential endocrine control mechanisms have been identified, and recent evidence suggests that paracrines such as endothelin, nitric oxide, and prostaglandins might also control MRC function.

David H. Evans (University of Florida Zoology)

2008-06-04

475

EDAD Y CRECIMIENTO DEL TIBURÓN MARTILLO Sphyrna lewini (GRIFFITH Y SMITH, 1834) EN EL PACÍFICO CENTRAL DE MÉXICO AGE AND GROWTH FOR THE SCALLOPED HAMMERHEAD SHARK, Sphyrna lewini (GRIFFITH AND SMITH, 1834) ALONG THE CENTRAL PACIFIC COAST OF MEXICO  

Microsoft Academic Search

The age and growth of the scalloped hammerhead shark, Sphyrna lewini (Griffith and Smith, 1834) were estimated from rings on the vertebral centrum in 101 individuals (51 females and 50 males) from 260 organisms obtained from commercial fisheries off the coast of Michoacán, Mexico (18º10'N, 103º10'W). Results show that immediately after birth, a first ring is formed. Later we observed

Vicente Anislado-Tolentino; Carlos Robinson-Mendoza

476

Taking the middle ground, where the path is most clear: Reply to Smith (2013) and Denollet (2013).  

PubMed

We appreciate the thoughtful comments on Marin and Miller (2013). Both commentaries questioned the validity of our conclusions about interpersonal sensitivity (IS) and health, with Smith (2013) arguing that we overstated the conclusions and Denollet (2013) arguing that we did not take them far enough. Here we offer a middle-ground approach to interpreting the IS-health literature. We discuss our rationale for including introversion as an IS construct, and we point readers to high-quality evidence that specifically rules out some of the competing explanations raised by Smith (2013). Finally, we argue that additional work in this area is needed before specific hypotheses about biological mechanisms and the roles of age and disease stage as possible moderators can be tested. (PsycINFO Database Record (c) 2013 APA, all rights reserved). PMID:24016234

Marin, Teresa J; Miller, Gregory E

2013-09-01

477

First Measurements of the Longitudinal Bunch Profile at SLAC Using Coherent Smith-Purcell Radiation at 28GeV  

SciTech Connect

Coherent Smith-Purcell radiation has been demonstrated as a technique for measuring the longitudinal profile of charged particles bunches in the low to intermediate energy range. However, with the advent of the International Linear Collider, the need has arisen for a non-invasive method of measuring the bunch profile at extremely high energies. Smith-Purcell radiation has been used for the first time in the multi-GeV regime to measure the longitudinal profile of the 28GeV SLAC beam. The experiment has both successfully determined the bunch length, and has also demonstrated its sensitivity to bunch profile changes. The challenges associated with this technique, and its prospects as a diagnostic tool are reported here.

Blackmore, V.; Doucas, G.; Ottewell, B.; Perry, C.; /Oxford U.; Kimmitt, M.F.; /Essex U.; Arnold, R.; Molloy, S.; Woods, M.; /SLAC

2011-11-02

478

Mild Smith-Lemli-Opitz syndrome: further delineation of 5 Polish cases and review of the literature.  

PubMed

Smith-Lemli-Opitz syndrome (SLOS) is an autosomal recessive disorder caused by reduced activity of 7-dehydrocholesterol reductase, resulting in an increased concentrations of 7-dehydrocholesterol and 8-dehydrocholesterol in body fluids and tissues. Phenotypically it is characterized by wide range of abnormalities, from mild to lethal forms what causes difficulties in its clinical diagnostics. To further delineate the physical spectrum of the mild form of Smith-Lemli-Opitz syndrome, especially with regard to genotype-phenotype correlation, we describe 5 Polish patients with mild phenotype (one with novel mutation in DHCR7 gene and four published before) and analyze 18 other cases from the literature. As the conclusion we give recommendation for tests toward SLOS in cases with "idiopathic" intellectual impairment and/or behavioral anomalies, as well as in biochemically doubtful but clinically fitting cases with overall gestalt and history of this syndrome. PMID:18249054

Jezela-Stanek, A; Ciara, E; Malunowicz, E M; Korniszewski, L; Piekutowska-Abramczuk, D; Popowska, E; Krajewska-Walasek, M

2007-12-08

479

Assessment of Outputs from Smith-Root Model5.0 GPP and Model7.5 GPP Electrofishers  

Microsoft Academic Search

We evaluated the outputs from eight Smith-Root electrofishers (two factory-rigged model-5.0 GPP boats, four biologist-rigged model-5.0 GPP boats, and two biologist-rigged model-7.5 GPP boats), using an oscilloscope to determine the actual waveforms (voltage as a function of time), current, and power produced for various settings. Differences were found in average power outputs among the six model-5.0 GPP electrofishing boats. In

Kevin L. Pope; Brian E. Van Zee; Michael C. Mayo; Mohammed Rahman

2001-01-01

480

Hydrogeologic subdivision of the Wolfcamp Series and Pennsylvanian System of the Deaf Smith study area, Texas: Revision 1, Topical report  

Microsoft Academic Search

The Pennsylvanian-Wolfcamp section in the Palo Duro Basin includes brine aquifers that are considered to be the most important ground-water flow paths in the deep-basin system. This particular study area comprises eight counties in Texas, centered in Potter County (and including Deaf Smith County). Underground patterns of rock distribution are delineated from a hydrologic perspective and at a level of

P. C. Siminitz; E. A. Warman

1987-01-01

481

Soil characteristics of two locations in Swisher and Deaf Smith Couties, Palo Duro Basin, Texas. [Contains glossary  

SciTech Connect

The soil is the resource on which the important economic activity of both the Swisher County and Deaf Smith County locations is based. Soils are discussed in terms of where they occur on the natural landscape. Major soil associations and the primary soil series included in them are described for both locations. Agricultural, engineering and reclamation interpretations are drawn from three published soil surveys. Field inspection of location soils was not performed.

Not Available

1984-12-01

482

Markedly inhibited 7-dehydrocholesterol-delta 7-reductase activity in liver microsomes from Smith-Lemli-Opitz homozygotes.  

PubMed Central

We investigated the enzyme defect in late cholesterol biosynthesis in the Smith-Lemli-Opitz syndrome, a recessively inherited developmental disorder characterized by facial dysmorphism, mental retardation, and multiple organ congenital anomalies. Reduced plasma and tissue cholesterol with increased 7-dehydrocholesterol concentrations are biochemical features diagnostic of the inherited enzyme defect. Using isotope incorporation assays, we measured the transformation of the precursors, [3 alpha- 3H]lathosterol and [1,2-3H]7-dehydrocholesterol into cholesterol by liver microsomes from seven controls and four Smith-Lemli-Opitz homozygous subjects. The introduction of the double bond in lathosterol at C-5[6] to form 7-dehydrocholesterol that is catalyzed by lathosterol-5-dehydrogenase was equally rapid in controls and homozygotes liver microsomes (120 +/- 8 vs 100 +/- 7 pmol/mg protein per min, P = NS). In distinction, the reduction of the double bond at C-7 [8] in 7-dehydrocholesterol to yield cholesterol catalyzed by 7-dehydrocholesterol-delta 7-reductase was nine times greater in controls than homozygotes microsomes (365 +/- 23 vs 40 +/- 4 pmol/mg protein per min, P < 0.0001). These results demonstrate that the pathway of lathosterol to cholesterol in human liver includes 7-dehydrocholesterol as a key intermediate. In Smith-Lemli-Opitz homozygotes, the transformation of 7-dehydrocholesterol to cholesterol by hepatic microsomes was blocked although 7-dehydrocholesterol was produced abundantly from lathosterol. Thus, lathosterol 5-dehydrogenase is equally active which indicates that homozygotes liver microsomes are viable. Accordingly, microsomal 7-dehydrocholesterol-delta 7-reductase is inherited abnormally in Smith-Lemli-Opitz homozygotes.

Shefer, S; Salen, G; Batta, A K; Honda, A; Tint, G S; Irons, M; Elias, E R; Chen, T C; Holick, M F

1995-01-01

483

Strath terrace formation and knickpoint migration in a coastal watershed draining to the Cascadia subduction margin, Smith River, northern California  

Microsoft Academic Search

Strath terrace formation and knickpoint migration along mainstem channels are indicators of landscape response to tectonic forcing in the Smith River watershed. The watershed (1,575 km2) is a bedrock dominated coastal basin in northern-most California. Aerial photographs, 10 m and 1 m digital elevation models, and field investigations were used to map strath terraces and determine modern and paleo-channel elevations

D. J. Caldwell; H. M. Kelsey

2010-01-01

484

On the modified Smith predictor for controlling a process with an integrator and long dead-time  

Microsoft Academic Search

A dead-time compensator for controlling higher-order processes with integral action and long dead-time is proposed. Tuning formulas are derived. If the velocity gain and the dead-time are estimated experimentally, only one parameter, the time constant defining the speed of the closed-loop setpoint response, has to be tuned manually. The same setpoint response is obtained as in the modified Smith predictor,

M. R. Matausek; Aleksandar D. Micic

1999-01-01

485

Mutations of RAI1, a PHD-containing protein, in nondeletion patients with Smith-Magenis syndrome  

Microsoft Academic Search

Smith-Magenis syndrome (SMS) is a mental retardation\\/multiple congenital anomalies disorder associated with a heterozygous ~4-Mb deletion in 17p11.2. Patients with SMS show variability in clinical phenotype despite a common deletion found in >75–80% of patients. Recently, point mutations in the retinoic acid induced 1 ( RAI1) gene, which lies within the SMS critical interval, were identified in three patients with

Weimin Bi; G. Mustafa Saifi; Christine J. Shaw; Katherina Walz; Patricia Fonseca; Meredith Wilson; Lorraine Potocki; James R. Lupski

2004-01-01

486

The Department of Obstetrics and Gynecology at Yale: the first one hundred fifty years, from Nathan Smith to Lee Buxton.  

PubMed Central

The persons who directed the academic teaching of women's health at Yale Medical School are presented by biographical sketches recounting their achievements and some of the difficulties they encountered. Three who provided particular catalysis were Nathan Smith, Herbert Thoms, and Lee Buxton. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 Figure 9 Figure 10 Figure 11 Figure 12 Figure 13 Figure 14 Figure 15 Figure 16 Figure 17

Kohorn, E. I.

1993-01-01

487

Impact assessment report: R. Paul Smith Steam Electric Station aquatic monitoring program. Volume II. Appendices. Final report  

SciTech Connect

This document is a summary and interpretation of findings from aquatic monitoring studies that have been conducted since 1976 at the site of the R. Paul Smith Steam Electric Station on the upper Potomac River. Because the studies are very diverse and most of the findings are in numerous unpublished reports, this report serves as a compendium of results and also integrates the findings into a meaningful assessment of plant effects.

Janicki, A.J.; Johnson, G.F.; Summers, J.K.; Smith, R.P.; Ross, R.N.

1981-06-01

488

Evaluation of R. Paul Smith Steam Electric Station thermal discharge effects on benthic communities; Spring 1980. Final report  

SciTech Connect

A study of thermal effluent effects on benthic invertebrates was conducted near the R.P. Smith Steam Electric Station. Samples were collected during May 1980 with a dome suction sampler and an aquatic drift net. Samples were collected on upstream and downstream control transects and on transects in the thermally influenced area. The objective of this survey was to assess effects of thermal discharge on the abundance and biomass macroinvertebrates in the Potomac River.

Not Available

1980-09-01

489

Response of northern corn rootworm, Diabrotica barberi Smith and Lawrence, to stereoisomers of 8-methyl-2-decyl propanoate  

Microsoft Academic Search

The four stereoisomers of 8-methyl-2-decyl propanoate were tested in South Dakota for attractiveness to the northern corn rootworm,Diabrotica barberi Smith and Lawrence (NCR). Only the 2R,8R configuration was attractive to the NCR. Inhibition of the NCR response to 2R,8R occurred when either the 2S,8R or 2S,8S isomers were components of the pheromone source. The 2R,8S configuration elicited no behavioral activity

P. L. Guss; P. E. Sonnet; R. L. Carney; J. H. Tumlinson; P. J. Wilkin

1985-01-01

490

Increased nonsterol isoprenoids, dolichol and ubiquinone, in the Smith-Lemli-Opitz syndrome: effects of dietary cholesterol  

Microsoft Academic Search

Smith-Lemli-Opitz syndrome (SLOS) is an inher- ited autosomal recessive cholesterol deficiency disorder. Our studies haveshownthat inSLOSchildren,urinary meva- lonate excretion is normal and reflects hepatic HMG-CoA reductase activity but not ultimate sterol synthesis. Hence, we hypothesized that in SLOS there may be increased di- version of mevalonate to nonsterol isoprenoid synthesis. To test our hypothesis, we measured urinary dolichol and ubiquinone,

Anuradha S. Pappu; William E. Connor; Louise S. Merkens; Julia M. Jordan; Jennifer A. Penfield; D. Roger Illingworth; Robert D. Steiner

2006-01-01

491

Anticonvulsant, anxiolytic, and sedative properties of the roots of Nauclea latifolia Smith in mice.  

PubMed

Root bark of Nauclea latifolia Smith (Rubiaceae) was evaluated for its anticonvulsant, anxiolytic, and sedative activity in mice. Animal models (maximal electroshock-, pentylenetetrazol-, and strychnine-induced convulsions; N-methyl-D-aspartate-induced turning behavior; elevated plus maze; stress-induced hyperthermia; open field; and diazepam-induced sleep) were used. The decoction from the bark of the roots of N. latifolia strongly increased the total sleep time induced by diazepam. It also protected mice against maximal electroshock-, pentylenetetrazol-, and strychnine-induced seizures. In addition, turning behavior induced by N-methyl-D-aspartate was inhibited. N. latifolia antagonized, in a dose-dependent manner, stress-induced hyperthermia and reduced body temperature. In the elevated plus maze, N. latifolia increased the number of entries into, percentage of entries into, and percentage of time in open arms, and reduced rearing, head dipping, and percentage of time in closed arms. In the open field test, N. latifolia increased crossing and reduced rearing and defecation. It could be concluded that the decoction of N. latifolia, used in traditional medicine in Cameroon in the treatment of fever, malaria, insomnia, anxiety and epilepsy seemed to possess, sedative, anticonvulsant, anxiolytic and antipyretic properties in mice. PMID:19560975

Ngo Bum, E; Taiwe, G S; Moto, F C O; Ngoupaye, G T; Nkantchoua, G C N; Pelanken, M M; Rakotonirina, S V; Rakotonirina, A

2009-06-27

492

Desperately seeking social approval: Adam Smith, Thorstein Veblen and the moral limits of capitalist culture.  

PubMed

Adam Smith and Thorstein Veblen shared much in matters of economic ontology. Both dismissed the very notion of an autonomous economic self and instead investigated the processes through which self and other are mutually constituted under changing cultural traditions of individual aspiration. Their strikingly similar critiques of status-oriented consumption and concern for the moral basis of the market economy are established in this manner. However, the political implications of their analyses point in different directions, with Veblen being the more radical. The Smithian individual can always use spectatorial insights to assert through genuinely praiseworthy behaviour personal moral distance from social norms of status-oriented consumption. The Veblenian individual, by contrast, has no such capacity for elevating abstract moral principles above socially-situated conduct, as mind and environment co-evolve in line with changing material circumstances of life. For Veblen, the rise of status-oriented consumption itself acted as a form of moral self-education that more deeply entrenched the social norms of ownership out of which it arose, thus the impossibility of an autonomous economic self was matched by the impossibility of an autonomous moral self. To his way of thinking, moral degradation in conspicuous consumption was irredeemably inscribed into the whole cultural structure of capitalism. PMID:22950465

Watson, Matthew

2012-09-01

493

Site study plan for exploratory shaft monitoring wells, Deaf Smith County Site, Texas: Preliminary Draft  

SciTech Connect

As part of site characterization studies, two exploratory shafts will be constructed at the Deaf Smith County site, Texas. Twelve wells at five locations have been proposed to monitor potential impacts of shaft construction on water-bearing zones in the Ogallala Formation and the Dockum Group. In addition, tests have been proposed to determine the hydraulic properties of the water-bearing zones for use in design and construction of the shafts. Samples of the Blackwater Draw Formation, Ogallala Formation, and Dockum Group will be obtained during construction of these wells. Visual indentification, laboratory testing, and in situ testing will yield data necessary for Exploratory Shaft Facility design and construction. This activity provides the earliest data on the Blackwater Drew Formation, Ogallala Formation, and Dockum Group near the exploratory shaft locations. Drilling and hydrologic testing are scheduled prior to other subsurface activity at the Exploratory Shaft Facility to establish ground-water baseline conditions. The Technical Field Services Contractor is responsible for conducting the field program of drilling and testing. Samples and data will be handled and reported in accordance with established Salt Repository Project procedures. A quality assurance program will be utilized to assure that activities affecting quality are performed correctly and that the appropriate documentation is maintained. 45 refs., 11 figs., 4 tabs.

Not Available

1988-01-01

494

Plasma Plant Sterols Do Not Reflect Cholesterol Absorption in Smith-Lemli-Opitz Syndrome Children  

PubMed Central

Objective In adults, the ratio of plant sterols to cholesterol in plasma correlates with dietary cholesterol absorption. We hypothesized that this correlation could be validated in children with Smith Lemli-Opitz syndrome (SLOS), a cholesterol synthesis disorder. Study design We obtained measurements of cholesterol absorption by a direct radioisotope cholesterol absorption method during 9 SLOS subject visits. We measured plasma sterols in 22 SLOS subjects and 16 controls, as well as dietary intake of cholesterol and sitosterol (n=11 SLOS). Results The correlations of 2 plasma plant sterol ratios (sitosterol/cholesterol and campesterol/cholesterol) with direct cholesterol absorption measurement were poor (R= ?0.33 and R= ?0.25, respectively), significantly lower than the published correlation in adults (R=+0.73) (P<0.02). Conclusions Although the ratios of plant sterols to cholesterol in plasma has been used as a surrogate for cholesterol absorption in adults and children, these ratios may not accurately reflect cholesterol absorption in children with SLOS. These ratios should not be used as a surrogate for cholesterol absorption in children without further validation.

Merkens, Louise S.; Jordan, Julia M.; Penfield, Jennifer A.; Lutjohann, Dieter; Connor, William E.; Steiner, Robert D.

2011-01-01

495

Reducing risk factors for childhood obesity: the Tommie Smith Youth Athletic Initiative.  

PubMed

This study has sought to determine if the Tommie Smith Youth Athletic Initiative (TSYAI) intervention could decrease the risk factors for childhood obesity among children 5 to 10 years of age. The TSYAI intervention is a 14-week after-school intervention for students in Grades K-5 that was started during the spring of 2008. It serves 63 children in a predominantly African American elementary school. The intervention consists of supervised after-school sessions 3 days per week. These sessions include 2 days of physical activity (flexibility, resistance, and track-and-field training) and 1 day of 45 min of nutrition education modules based on the Transtheoretical Model of behavior change followed by 45 min of group physical activity. Ninety-two percent of the participants are African American and 60% are overweight or obese (>85th percentile BMI for age and gender). The findings indicate that the TSYAI intervention significantly improves the participant's cardiovascular fitness, body composition, and dietary habits. PMID:19454750

Topp, Robert; Jacks, Dean E; Wedig, Rita Thomas; Newman, Jamie L; Tobe, Lisa; Hollingsworth, Angela

2009-05-19

496

Water supply and use in Deaf Smith, Swisher, and nearby counties in the Texas Panhandle  

SciTech Connect

Irrigation for agriculture is the primary water use in the area of Deaf Smith and Swisher Counties, Texas, and the Ogallala Formation is the main water source. The availability of water in the 12-county area is projected to decrease markedly over the next 5 decades because of the steady depletion of ground water in recoverable storage. Water requirements in the 12-county area are projected to exceed available supplies from about 1990 through 2030. The shortage for the year 2030 is estimated to be approximately 4 million acre-feet under high-growth-rate conditions. Because of its semiarid climate, the area has little available surface water to augment the supply of the Ogallala Formation, which, despite its depletion, could be the principal source of water for the repository. There are, however, other potential sources of water: (1) Lake Mackenzie, on Tule Creek; (2) the Santa Rosa Formation, which underlies much of the Southern High Plains and locally yields moderate amounts of good-quality water; and (3) the Wolfcamp Series, which yields low amounts of highly saline water. The effluents of municipal wastewater treatment plants and municipal water systems may also be useful as supplements to the repository's primary water supply.

Not Available

1985-02-01

497

Site study plan for Deep Hydronest Test Wells, Deaf Smith County Site, Texas: Preliminary draft  

SciTech Connect

Wells called Deep Hydronest Wells will be installed at six locations at the Deaf Smith County Site to characterize hydraulic parameters in the geologic column between the top of the San Andres Formation and the base of Pennsylvanian System. Three hydronests will be drilled during early stages of site characterization to provide data for performance assessment modeling. Four wells are proposed for each of these 3 nests. Results of drilling, testing, and preliminary modeling will direct drilling and testing activities at the last 3 nests. Two wells are proposed at each of the last 3 nests for a total of 18 wells. The Salt Repository Project (SRP) Networks specify the schedule under which this program will operate. Drilling and hydrologic testing of the first Deep Hydronest will begin early in the Surface Investigation Program. Drilling and testing of the first three Deep Hydronests will require about 18 months. After 12 months of evaluating and analyzing data from the first three hydronests, the remaining three hydronests will be drilled during a 12-month period. The Technical Field Services Contractor is responsible for conducting the field program. Samples and data will be handled and reported in accordance with established SRP procedures. A quality assurance program will be used to assure that activities affecting quality are performed correctly and that the appropriate documentation is maintained. 36 refs., 20 figs., 6 tabs.

Not Available

1987-05-01

498

Technical procedures for implementation of aesthetics site studies, Deaf Smith County site, Texas: Environmental Field Program  

SciTech Connect

This chapter introduces the purpose and scope of the visually affected areas determination, as well as definitions, interfaces, and concurrent data needs. This procedure provides a method for determining the extent of visibility of the project. This area is identified as the visually affected area, and becomes the area within which all visual analysis is conducted. The visually affected area analysis of the Deaf Smith County site will involve identifying and mapping the visibility of all major proposed project features. Baseline analysis will be conducted within the overall visually affected area; impact assessment will be conducted within the visually affected area of each major project feature. This procedure presents the guidelines for determining the visually affected area will be in computer data base construction; viewshed modeling, and site visit and verification of results. Computer data base construction will involve digitizing topographic and project facility data from available data source. The extent of the visible area from each major project feature will then be plotted. Finally, these computer-generated visibility plots will be verified in the field.

Not Available

1987-06-01

499

Characteristics of terrestrial and aquatic ecosystems of two locations in Deaf Smith and Swisher Counties, Texas  

SciTech Connect

According to the Civilian Radioactive Waste Management Program and the Nuclear Waste Policy Act of 1982 (P.L. 97-425), a potential nuclear waste repository site must be chosen with consideration of potential impacts on terrestrial and aquatic ecosystems. This report is a preliminary environmental characterization of two locations in the Texas Panhandle, one in Deaf Smith County and the other in Swisher County, that have been recommended for further study. A description of important natural areas is offered as a basis for comparative studies of the two locations and for the identification and screening of potential repository sites. Information on current land uses, potential habitats, and expected plant and wildlife species is provided to assist field investigators in the collection of baseline data in support of further siting activities. The results of limited field surveys are also included. The report is in two parts. Part I contains a characterization of terrestrial ecological resources based upon limited field surveys aimed at verifying the presence of plant communities and wildlife habitats. It also presents inventories of species with special status, species with recreational and economic importance, and species of ecological value to important or special-status species. Part II presents information on aquatic ecosystems and resources derived primarily from a review of the literature, interviews, and limited field surveys. 21 figures, 18 tables.

Not Available

1984-11-01

500

Site study plan for routine laboratory rock mechanics, Deaf Smith County Site, Texas: Revision 1  

SciTech Connect

This Site Study Plan for Routine Laboratory Rock Mechanics describes routine laboratory testing to be conducted on rock samples collected as part of the characterization of the Deaf Smith County site, Texas. This study plan describes the early laboratory testing. Additional testing may be required and the type and scope of testing will be dependent upon the results of the early testing. This study provides for measurements of index, hydrological, mechanical, and chemical properties with tests which are standardized and used widely in geotechnical investigations. Another Site Study Plan for Nonroutine Laboratory Rock Mechanics describes laboratory testing of samples from the site to determine mechanical, thermomechanical, and thermal properties by less widely used methods, many of which have been developed specifically for characterization of the site. Data from laboratory tests will be used for characterization of rock strata, design of shafts and underground facilities, and modeling of repository behavior in support of resolution of both preclosure and postclosure issues. A tentative testing schedule and milestone log are given. A quality assurance program will be utilized to assure that activities affecting quality are performed correctly and that appropriate documentation is maintained. 18 refs., 8 figs., 3 tabs.

Not Available

1987-12-01