Sample records for glaxo smith kline

  1. Scientists in Sport, the 2012-Inspired GlaxoSmithKline Schools Outreach Programme

    ERIC Educational Resources Information Center

    Gadd, Mark

    2012-01-01

    The GlaxoSmithKline Scientists in Sport team have worked with 4science to provide resources and offer activities for use by schools to show the relevance of science in sport. Much of the content looks at anti-doping and the science involved with detecting the misuse of banned substances. Through the development of a website, this work can continue…

  2. Preparing individual patient data from clinical trials for sharing: the GlaxoSmithKline approach.

    PubMed

    Hughes, Sara; Wells, Karen; McSorley, Paul; Freeman, Andrew

    2014-01-01

    In May 2013, GlaxoSmithKline (980 Great West Road, Brentford, Middlesex, TW8 9GS, UK) established a new online system to enable scientific researchers to request access to anonymised patient level clinical trial data. Providing access to individual patient data collected in clinical trials enables conduct of further research that may help advance medical science or improve patient care. In turn, this helps ensure that the data provided by research participants are used to maximum effect in the creation of new knowledge and understanding. However, when providing access to individual patient data, maintaining the privacy and confidentiality of research participants is critical. This article describes the approach we have taken to prepare data for sharing with other researchers in a way that minimises risk with respect to the privacy and confidentiality of research participants, ensures compliance with current data privacy legal requirements and yet retains utility of the anonymised datasets for research purposes. We recognise that there are different possible approaches and that broad consensus is needed. PMID:24668938

  3. Feasibility Study of GlaxoSmithKline Biologicals' GSK2202083A Vaccine in Healthy Infants at 3, 5 and 11 Months of Age.

    ClinicalTrials.gov

    2012-11-16

    Haemophilus Influenzae Type b; Poliomyelitis; Hepatitis B; Serogroup C Meningococcal Diseases; Diphtheria; Pertussis; Diphtheria-Tetanus-aPertussis-Hepatitis B-Poliomyelitis-Haemophilus Influenzae Type b-Neisseria Meningitidis Vaccines; Tetanus

  4. Zanamivir (Glaxo Wellcome).

    PubMed

    Oxford, J S

    2000-04-01

    Zanamivir, a neuraminidase inhibitor under license from Biota, has been developed and launched by Glaxo Wellcome for the treatment of influenza virus infection [277127]. While registered as drugs, neuraminidase inhibitors are technically vaccines as they are believed to work by provoking an immune response, thus preventing the spread of infection from one cell to another within the respiratory tract [314356]. It is administered, using an inhaler, directly to where the virus replicates, minimizing the potential for side effects. Zanamivir has been launched, under the name Relenza, for the treatment of influenza in Australia [325148], New Zealand [335591] and the UK [341871]. It is registered in Mexico and Armenia [346474], and approved in Japan [351580]. In October 1999, it was launched in the US [352392] and Glaxo confirmed in January 2000, that zanamivir has been launched all over Europe, with the exception of Greece and Spain, where launch is imminent [352513]. In October 1999, the British Pharma Group (BPG) wrote to the UK Prime Minister to seek a discussion on the implications for the British-based pharmaceutical industry of the recommendation from NICE's Raised Appraisal Committee that Relenza should be banned from the NHS [342597]. An FDA submission was made in October 1998 [302732,304779]; the FDA advisory committee met on February 24 1999 to discuss the application [313583]. The Antivirals Drugs Advisory Committee voted against recommending zanamivir for FDA approval [316196]. Members suggested that additional studies using a different endpoint or targeting specific high-risk populations would be more likely to garner support [317454]. Following a discussion with Glaxo Wellcome in April 1999, the FDA indicated that it would continue to review the NDA for zanamivir [320565]. In July 1999, the company received final FDA approval for the drug for the treatment of both influenza A and B [334127], and aimed to initiate a phase IV trial program for the detection of consumer problems with the product, following launch of the product in time for the 1999-2000 flu season [352392,335048]. In September 1998, Glaxo applied to the Canadian Health Protection Branch (HPB) for approval to market zanamivir for the treatment and prevention of influenza. A separate application for Fast Track approval was also made with the HPB [299375,299472]. In November 1999, zanamivir received approval in Canada [346474]. Glaxo expects to make MAA and NDA filings for the use of zanamivir as a prophylactic in 1999 [333494]. In July 1998, Merrill Lynch predicted that as zanamivir offered only modest benefits gained from a narrow treatment window, potential would be limited and forecast annual sales of US dollar 30 million [302048]. In January 1999, Paribas predicted sales of pounds 75 million in 1999, rising to pounds 280 million in 2003 [317650]. In April 1999, ABN Amro predicted sales of pounds 23 million in 1999, rising to pounds 326 million in 2003 [328676]. In August 1999, Lehman Brothers estimated that sales of zanamivir will reach US dollar 400 million by 2003, and that it is an obvious candidate for an OTC switch, although this is not likely until 5 years after launch [336356]. PMID:16100701

  5. Protective effects of a peroxisome proliferator-activated receptor-h/y agonist in experimental autoimmune encephalomyelitis

    E-print Network

    Omiecinski, Curtis

    's Affairs Research Division, Chicago, IL, 60612, United States b Department of Veterinary Science and Center States c GlaxoSmithKline Pharmaceuticals, Harlow, UK d GlaxoSmithKline, Discovery Research, 5 Moore Drive

  6. IMPORTANT PRESCRIBING INFORMATION Dear Healthcare Professional: GlaxoSmithKline (GSK) would like to advise you that it is changing the Pregnancy subsection of the PRECAUTIONS section in the labels for PAXIL ® (paroxetine HCl) and PAXIL CR ® (paroxetine HCl) Controlled-Release Tablets

    Microsoft Academic Search

    Three Franklin Plaza

    SUMMARY • Paroxetine currently carries a Category C pregnancy precaution, indicating that there are no adequate and well-controlled studies in humans to determine the effect of paroxetine on the fetus. Labeling states that the drug should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. The label also currently includes information related to

  7. Quantifying the Impact of Prostate Volumes, Number of Biopsy Cores and 5 -Reductase Inhibitor Therapy on the

    E-print Network

    Serfling, Robert

    and Department of Urology (MS, CGR), University of Texas Southwest Medical Center at Dallas and Dallas Urology at Charlotte (ZX), Charlotte and Urology Clinical Development and Medical Affairs Group, GlaxoSmithKline (RR

  8. Regulation of oligodendrocyte progenitor cell maturation by PPARd: effects on

    E-print Network

    Omiecinski, Curtis

    of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, U.S.A. GlaxoSmithKline Pharmaceuticals, New Frontiers Science Park, Harlow, Essex CM19 5AW, U.K. Cite

  9. 78 FR 43210 - Bracco Diagnostics et al.; Withdrawal of Approval of 52 New Drug Applications and 77 Abbreviated...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-19

    ...base), EQ 2 mg (base). NDA 020336................. DynaCirc CR GlaxoSmithKline, (isradipine) 2301 Renaissance Controlled-Release Blvd., King of Tablets. Prussia, PA 19406. NDA 020343....................

  10. 77 FR 32125 - Oncologic Drugs Advisory Committee; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-31

    ...application (sNDA) 022059/014 with the trade name Tykerb (lapatinib) tablets, application submitted by SmithKline Beecham (Cork) Ltd, Ireland d/b/a GlaxoSmithKline. The proposed indication (use) for this product is in combination with...

  11. TRAINING TOMORROW'S 02MESSAGE FROM DEVELOPMENT AND

    E-print Network

    Barthelat, Francois

    Cohen Prize in Ophthalmology with a donation of $10,000 for a graduating medical student pursuingSmithKline-CIHR Professorship in Pharmacology at McGill, GlaxoSmithKline has made a donation of $500,000 to create the GSK organization that provides comprehensive and innovative care to cancer patients and their families and friends

  12. Training and Development of Clinical Research Personnel through the Glaxo Professional Development Program

    Microsoft Academic Search

    Kevin Darryl White; David M. Cocchetto

    1992-01-01

    Employees in clinical research and its supportive functions bring a heterogeneous collection of formal educations, health care training, scientific training, and work experiences to their positions in the pharmaceutical industry. To promote their success in industry, in 1985 Glaxo established a three-part intracompany Professional Development Program. The first part of this program is the Core Program which facilitates assimilation of

  13. BAYESIAN STATISTICS 9, J. M. Bernardo, M. J. Bayarri, J. O. Berger, A. P. Dawid,

    E-print Network

    Madigan, David

    David Madigan Columbia University, U.S.A. madigan@stat.columbia.edu Patrick Ryan Glaxo drugs have acceptable benefit-risk profiles. This is an intricate and David Madigan is Professor University. Patrick Ryan is a Research Scientist at GlaxoSmithKline. #12;2 D. Madigan et al. ongoing process

  14. k-line iterative methods: a conjugate-gradient approach

    SciTech Connect

    Kratzer, D.; Parter, S.V.; Steuerwalt, M.

    1981-03-29

    The generalized conjugate gradient scheme based on the k-line block Jacobi splitting A = M-N was studied for solving model two-dimensional parabolic and elliptic difference equations AU = F tilde. A represents the matrix ch/sup ..cap alpha../-h/sup 2/..delta../sub h/. Eigenvalues of M/sup -1/N cluster, and the cluster radii decrease as ch/sup ..cap alpha../ or k increases. Computations with k = 4, 8, 16, 32, and ch/sup ..cap alpha../ = 0, h, 2 are discussed.

  15. David G. Kline, MD Endowed Chair in Peripheral Nerve Repair and Regeneration

    E-print Network

    . Kline, MD became the founding Chairman of the LSUHSC Neurosurgery Department establishing international remained chairman of the Neurosurgery Department until he stepped down in 2006. The David G. Kline, M the Neurosurgery Department to carry on his legacy by attracting an outstanding clinician/researcher to the chair

  16. Eddie Smith Dean E. Smith

    E-print Network

    Whitton, Mary C.

    Daniels Hill Ackland McCaskill Paul Green Eddie Smith Alumni Center Carmichael Auditorium Center Student Dean E. Smith Student Hall Kenan Field House Bookstore Affairs Stadium Kenan Hill Williams House Forest

  17. Eddie Smith Dean E. Smith

    E-print Network

    Doyle, Martin

    Excellence Center for Loudermilk Graham Memorial Daniels Hill Ackland McCaskill Paul Green Eddie Smith Alumni Center Carmichael Arena Center Student Dean E. Smith Student Hall Kenan Field HouseStadium Kenan Hill

  18. Virginia M. Kline Collection: Ecological Communities of Wisconsin

    NSDL National Science Digital Library

    Dr. Virginia M. Kline was a plant ecologist who worked at the University of Wisconsin Arboretum for many years. She was an enthusiastic educator, and she also helped to develop the field of restoration ecology. For eleven years, she also team-taught the course "Vegetation of Wisconsin" with Professor Grant Cottam. As part of this work she created a series of slides designed to reflect the natural history of Wisconsin, past and present. Visitors to this digital collection can view these slides and also listen to a series of audiotapes from the course. All told, there are 1200 items in this collection, and visitors can view sets of images in galleries or perform more detailed searches across all of the items. Some of the photographs are quite beautiful and taken as a whole this collection offers a good overview of the plant life in southern Wisconsin.

  19. Symbiotic relationship between a research institute and a pharmaceutical company: the Baker Institute/Glaxo Australia story.

    PubMed

    Angus, J A

    1992-01-01

    1. The Baker Medical Research Institute is a non-profit, charitable institution to advance knowledge and solve problems in the area of cardiovascular medicine. This allows scientists to collaborate within a critical mass and be flexible in their approach to research. 2. The Institute has interactions with the pharmaceutical industry at three levels: (i) contract research on a specific molecule; (ii) clinical trials; and (iii) collaborative basic research agreements. 3. The Glaxo Australia-Baker Medical Research Institute Agreement is for curiosity driven research in specified areas of vascular pharmacology of interest to Glaxo Group Research. 4. The relationship between universities, research institutes and the pharmaceutical industry is discussed in terms of the starting point for drug development. 5. The enormous cost (US$100 million), lead time (10 years) and uncertainty of a successful profitable drug are compelling reasons why an independent pharmaceutical company is unlikely to succeed in Australia today. PMID:1623639

  20. Improving Doctor/Caregiver Communication

    MedlinePLUS

    ... that are partnering with us in support of NFC Month 2005 andThe Caring Every Day Campaign. Caring ... HealthCare AstraZeneca Family Partners:Eisai Inc. Novartis Pfizer NFC Month Partners: Brooks and Eckerd Pharmacy GlaxoSmithKline Johnson & ...

  1. N E W S I N B R I E F 234 VOLUME 13 | NUMBER 3 | MARCH 2007 NATURE MEDICINE

    E-print Network

    Cai, Long

    genes linked to breast cancer recurrence and can help determine whether women need additional FDA approves the first non- prescription diet drug, GlaxoSmithKline's Alli, expected to go on sale this month 10 Feb About 20% of women and 8% of men with lung cancer do not smoke

  2. Abstract --The inadequacy of the traditional, digitally encoded RFID tags in combating counterfeiting prompts us to

    E-print Network

    Tentzeris, Manos

    fabrication site to store is presented, and a strategy to block potential attacks is discussed. Our system. With Glaxo-Smith-Kline, in a study with the US Food and Drug Administration, estimating that counterfeit drugs account for 10% of the global pharmaceuticals market [1], the Business Software Alliance

  3. 77 FR 63839 - Vaccines and Related Biological Products Advisory Committee; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-17

    ...the safety and immunogenicity of an Influenza A (H5N1) Virus Monovalent Vaccine manufactured by GlaxoSmithKline. On...and make recommendations on the safety and efficacy of a Hepatitis B Vaccine manufactured by Dynavax. FDA intends to...

  4. PowerPoint Presentation

    Cancer.gov

    • Journal of the National Cancer Institute, ePub January 7, 2013; print: February, 2013 (issue 3) Disclosure • I am an inventor of NIH vaccine technology that has been licensed to Merck and GlaxoSmithKline, the two companies that manufacture the

  5. Degradative transport of cationic amphiphilic drugs across phospholipid bilayers

    E-print Network

    Rosso, Lula

    PET Imaging Department, GlaxoSmithKline, ACCI, Addenbrookes Hospital, Cambridge CB2 2GG, UK Drug Lipinskihas shownthatmost successful pharmaceuticaldrugs have a commonset of chemical properties (Kuroda). Many of these properties appear to correspond to factors that enable drug molecules to cross

  6. Tadalafil and vardenafil

    Microsoft Academic Search

    Peter Kirkpatrick; Katherine Neumeyer

    2004-01-01

    In 2003, two inhibitors of phosphodiesterase 5 (PDE5) — tadalafil (Cialis; Lilly ICOS) and vardenafil hydrochloride (Levitra; Bayer\\/ GlaxoSmithKline) — were approved by the US FDA for the treatment of erectile dysfunction. Can they challenge the dominance of the first PDE5 inhibitor, sildenafil citrate (Viagra; Pfizer), which rapidly became a blockbuster following its market entry in the late 1990s?

  7. Complete List of Vaccines Licensed for Immunization and Distributed in the U.S.

    MedlinePLUS

    ... A. Haemophilus b Conjugate Vaccine (Meningococcal Protein Conjugate) & Hepatitis B Vaccine (Recombinant) Comvax Merck & Co, Inc Hepatitis A Vaccine, ... and Hepatitis B (Recombinant) Vaccine Twinrix GlaxoSmithKline Biologicals Hepatitis B Vaccine (Recombinant) Recombivax HB Merck & Co, Inc Hepatitis B ...

  8. Contacts: Olivia Goodman/Jennifer Robinson For immediate release: July 30, 2014 gabbegroup/212-220-4444

    E-print Network

    McGaughey, Alan

    solutions to combat acquaintance/date rape. Two novel product prototypes, targeted to the college population patents on both prototypes on the students' behalf. Of the roughly 12 million women enrolled in American at GlaxoSmithKline. 1 U.S. Department of Justice, "The Sexual Victimization of College Women," 2000. 2 U

  9. HPV - a vaccine against cervical cancer

    Microsoft Academic Search

    N. Desmond; H. Petousis-Harris; N. Turner

    2006-01-01

    Most cervical cancer is caused by Human papillomavirus (HPV). Protection against the major cancer-causing serotypes of this virus by vaccination is now a reality for New Zealand women. Internationally two manufacturers have candidate HPV vaccines: the bivalent Cervarix (GlaxoSmith Kline) and the tetravalent Gardasil (CSL and Merck & Co). This article focuses on Gardasil, as this vaccine is now available

  10. Ecological Effects in Malaria Vaccine Effectiveness in

    E-print Network

    Doyle, Martin

    Ecological Effects in Malaria Vaccine Effectiveness in Lilongwe, Malawi Cameron Taylor B component to a GlaxoSmithKline phase III trial vaccine trial so that researchers can better understand distribution and the ecological effects of both malaria transmission intensity and vaccine efficacy

  11. For personal use. Only reproduce with permission from Elsevier Ltd Perspectives

    E-print Network

    Colquhoun, David

    to enjoy good health. But Angell shows not only that the supply of truly innovative products has slowedFor personal use. Only reproduce with permission from Elsevier Ltd Perspectives The pharmaceutical towards stagna- tion. Global sales for AstraZeneca fell by 0·6% in 2003. GlaxoSmithKline grew by only 3

  12. Study of the immune response engendered by differents combined measles, mumps and rubella (MMR) vaccines in an area of Andalusia (Spain)

    Microsoft Academic Search

    Concepción Cruz Rojo; Manuel Rodr??guez Iglesias; Juana Olvera; Manuela Álvarez Girón

    2003-01-01

    The objective of the study is to evaluate and compare the degree of serological protection conferred by the three components of two MMR vaccines: “Vac triple MSD®” (Aventis Pasteur MSD) and “Triviraten®” (Berna), and to study the effects of a second dose of “Priorix®” (Glaxo SmithKline), in an unprotected population. In March 2001, this study was conducted in a sample

  13. Disconnected Youth in the Research Triangle Region: An Ominous Problem Hidden in Plain Sight

    ERIC Educational Resources Information Center

    Dodson, David; Guillory, Ferrel; Lipsitz, Joan; Raper, Noah; Rausch, Christina

    2008-01-01

    In September 2006, the North Carolina GlaxoSmithKline Foundation commissioned MDC, Inc. of Chapel Hill to analyze the problem of "disconnected youth" in the Research Triangle region, determine the current state of the region's responses to the challenge, and recommend steps to deepen and accelerate action on the issue. The research process was…

  14. Cell, Vol. 122, 195207, July 29, 2005, Copyright 2005 by Elsevier Inc. DOI 10.1016/j.cell.2005.07.005 The Drosophila Nuclear Receptor E75

    E-print Network

    Krause, Henry M.

    Research bind ligands such as steroid hormones and fat-solubleCharles H. Best Institute vitamins with high with lower affin-Toronto, Ontario, M5G 1L6 ity. Finally, nuclear receptors with no known ligands areCanada, reproduction,Canada and disease and because the nature of their ligands4 GlaxoSmithKline Inc. makes them

  15. Mathematical Robert Smith?

    E-print Network

    Maini, Philip K.

    Mathematical Modelling of Zombies Robert Smith? University of Ottawa Press #12;Robert Smith by Robert Smith? Includes bibliographical references. Issued in print and electronic formats. ISBN 978. I. Smith?, Robert J. (Robert Joseph), 1972­, editor GR581.M38 2014 398.2101'51 C2014-906565-5 C2014

  16. Absence epileptic activity changing effects of non-adenosine nucleoside inosine, guanosine and uridine in Wistar Albino Glaxo Rijswijk rats.

    PubMed

    Kovács, Z; Kékesi, K A; Dobolyi, Á; Lakatos, R; Juhász, G

    2015-08-01

    Adenosine (Ado) and non-adenosine (non-Ado) nucleosides such as inosine (Ino), guanosine (Guo) and uridine (Urd) may have regionally different roles in the regulation of physiological and pathophysiological processes in the central nervous system (CNS) such as epilepsy. It was demonstrated previously that Ino and Guo decreased quinolinic acid (QA)-induced seizures and Urd reduced penicillin-, bicuculline- and pentylenetetrazole (PTZ)-induced seizures. It has also been demonstrated that Ino and Urd may exert their effects through GABAergic system by altering the function of GABAA type of gamma-aminobutyric acid receptors (GABAA receptors) whereas Guo decreases glutamate-induced excitability through glutamatergic system, which systems (GABAergic and glutamatergic) are involved in pathomechanisms of absence epilepsy. Thus, we hypothesized that Ino and Guo, similarly to the previously described effect of Urd, might also decrease absence epileptic activity. We investigated in the present study whether intraperitoneal (i.p.) application of Ino (500 and 1000mg/kg), Guo (20 and 50mg/kg), Urd (500 and 1000mg/kg), GABAA receptor agonist muscimol (1 and 3mg/kg), GABAA receptor antagonist bicuculline (2 and 4mg/kg), non-selective Ado receptor antagonist theophylline (5 and 10mg/kg) and non-competitive N-methyl-d-aspartate (NMDA) receptor antagonist (+)-5-methyl-10,11-dihydro-5H-dibenzo (a,d) cyclohepten-5,10-imine maleate (MK-801, 0.0625 and 0.1250mg/kg) alone and in combination have modulatory effects on absence epileptic activity in Wistar Albino Glaxo Rijswijk (WAG/Rij) rats. We found that Guo decreased the number of spike-wave discharges (SWDs) whereas Ino increased it dose-dependently. We strengthened that Urd can decrease absence epileptic activity. Our results suggest that Guo, Urd and their analogs could be potentially effective drugs for treatment of human absence epilepsy. PMID:26037802

  17. An additional physical interpretation in the Luneburg-Kline expansion. [for reflected fields

    NASA Technical Reports Server (NTRS)

    Dominek, Allen K.; Peters, Leon, Jr.; Burnside, Walter D.

    1987-01-01

    The Luneburg-Kline (LK) expansion provides an asymptotic representation of the reflected field from a smooth surface in inverse powers of k. The physical interpretation of the first term in the expansion has long been recognized. The physical significance of the second term is suggested here. Through analysis of the expansion for a parabolic, circular, and elliptic cylinders, further geometric information is seen other than the radius of curvature at the specular point. The other geometric information is the distance between the specular point and the incident shadow boundary.

  18. An Atlas of K-line Spectra for Cool Magnetic CP Stars: The Wing-Nib Anomaly (WNA)

    E-print Network

    Cowley, C R; Kamp, I

    2005-01-01

    We present a short atlas illustrating the unusual Ca {\\sc ii} K-line profiles in upper main sequence stars with anomalous abundances. Slopes of the profiles for 10 cool, magnetic chemically peculiar (CP) stars change abruptly at the very core, forming a deep "nib." The nibs show the same or nearly the same radial velocity as the other atomic lines. The near wings are generally more shallow than in normal stars. In three magnetic CP stars, the K-lines are too weak to show this shape, though the nibs themselves are arguably present. The Ca {\\sc ii} H-lines also show deep nibs, but the profiles are complicated by the nearby, strong H$\\epsilon$ absorption. The K-line structure is nearly unchanged with phase in $\\beta$ CrB and $\\alpha$ Cir. Calculations, including NLTE, show that other possibilities in addition to chemical stratification may yield nib-like cores.

  19. An Atlas of K-line Spectra for Cool Magnetic CP Stars: The Wing-Nib Anomaly (WNA)

    E-print Network

    C. R. Cowley; S. Hubrig; I. Kamp

    2005-12-11

    We present a short atlas illustrating the unusual Ca {\\sc ii} K-line profiles in upper main sequence stars with anomalous abundances. Slopes of the profiles for 10 cool, magnetic chemically peculiar (CP) stars change abruptly at the very core, forming a deep "nib." The nibs show the same or nearly the same radial velocity as the other atomic lines. The near wings are generally more shallow than in normal stars. In three magnetic CP stars, the K-lines are too weak to show this shape, though the nibs themselves are arguably present. The Ca {\\sc ii} H-lines also show deep nibs, but the profiles are complicated by the nearby, strong H$\\epsilon$ absorption. The K-line structure is nearly unchanged with phase in $\\beta$ CrB and $\\alpha$ Cir. Calculations, including NLTE, show that other possibilities in addition to chemical stratification may yield nib-like cores.

  20. Joseph Smith the Prophet

    NSDL National Science Digital Library

    Mr. Shane Carter

    2006-10-23

    Just a quick look at the Prophet Joseph Smith\\'s life and all that he accomplished. As you go to the site below think of the following questions: What do you think was the greatest contribution the Prophet Joseph Smith made? What can you do today to show him your appreciation and to keep the work moving forward? Key Events in the Life of Joseph Smith While looking through the church sites ask yourself the following question: Which ...

  1. Joshua Smith Spring 2006

    E-print Network

    Rosemond, Amy Daum

    Stormwater Utilities in Georgia Joshua Smith Spring 2006 #12;The UGA Land Use Clinic provides in Georgia Author: Joshua Smith Editor: Jamie Baker Roskie University of Georgia Land Use Clinic Spring 2006....................................................................................................10 #12;#12;1Stormwater Utilities in Georgia Stormwater Utilities in Georgia Joshua Smith Spring 2006

  2. David Smith Academic background

    E-print Network

    David Smith Academic background Ph.D. in Mathematics (Algebra), Université de Sherbrooke, Canada project program (I. Assem, F. Bergeron, C. Reutenauer, D. Smith) $132,000 ($44,000 per year for 3 years. Schiffler and D. Smith, Friezes, strings and cluster variables, to appear in Glasgow Mathematcal Journal. 2

  3. World Vaccine Congress Lyon - Terrapinn's 11th Annual Congress.

    PubMed

    Sovran, Liza

    2009-12-01

    The 11th Annual World Vaccine Congress, held in Lyon, included topics covering new therapeutic developments in the field of vaccines. This conference report highlights selected presentations on the role of big pharma in vaccine development, the future direction of vaccine R&D, influenza preparedness in Europe, and vaccines for Staphylococcus aureus, CMV and cancer. Investigational drugs discussed include an H5N1 influenza vaccine program from Baxter International Inc/DynPort Vaccine Co LLC, FP-01 (Immune Targeting Systems Ltd), FluGEM (Mucosis BV), a nonstructural protein-1-altered live-attenuated influenza vaccine candidate from Vivaldi Biosciences Inc, PentaStaph (GlaxoSmithKline plc) and StaphVAX (Nabi Biopharmaceuticals), VCL-CB01 (Vical Inc) and astuprotimut-r (GlaxoSmithKline). PMID:19943212

  4. Solar Cycle Fine Structure and Surface Rotation from Ca II K-Line Time Series Data

    NASA Technical Reports Server (NTRS)

    Scargle, Jeff; Keil, Steve; Worden, Pete

    2011-01-01

    Analysis of three and a half decades of data from the NSO/AFRL/Sac Peak K-line monitoring program yields evidence for four components to the variation: (a) the solar cycle, with considerable fine structure and a quasi-periodicity of 122.4 days; (b) a stochastic process, faster than (a) and largely independent of it, (c) a quasi-periodic signal due to rotational modulation, and of course (d) observational errors (shown to be quite small). Correlation and power spectrum analyses elucidate periodic and aperiodic variation of these chromospheric parameters. Time-frequency analysis is especially useful for extracting information about differential rotation, and in particular elucidates the connection between its behavior and fine structure of the solar cycle on approximately one-year time scales. These results further suggest that similar analyses will be useful at detecting and characterizing differential rotation in stars from stellar light-curves such as those being produced at NASA's Kepler observatory.

  5. Adam Smith’s three strikes against commercial society

    Microsoft Academic Search

    James E. Alvey

    1998-01-01

    It is commonly held that Adam Smith is a prophet of capitalism. There is a good deal of evidence pointing towards his optimism about commercial society. This article claims to show the pessimistic side of Smith’s view of commercialism. While some of Smith’s pessimism is obvious, some emerges only after considering his six ends of human nature. We show that

  6. Malarone treatment failure and in vitro confirmation of resistance of Plasmodium falciparum isolate from Lagos, Nigeria

    Microsoft Academic Search

    Quinton L Fivelman; Geoffrey A Butcher; Ipemida S Adagu; David C Warhurst; Geoffrey Pasvol

    2002-01-01

    We report the first in vitro and genetic confirmation of Malarone® (GlaxoSmithKline; atovaquone and proguanil hydrochloride) resistance in Plasmodium falciparum acquired in Africa. On presenting with malaria two weeks after returning from a 4-week visit to Lagos, Nigeria without prophylaxis, a male patient was given a standard 3-day treatment course of Malarone®. Twenty-eight days later the parasitaemia recrudesced. Parasites were

  7. Drugs for bad bugs: confronting the challenges of antibacterial discovery

    Microsoft Academic Search

    David J. Payne; Michael N. Gwynn; David J. Holmes; David L. Pompliano

    2006-01-01

    The sequencing of the first complete bacterial genome in 1995 heralded a new era of hope for antibacterial drug discoverers, who now had the tools to search entire genomes for new antibacterial targets. Several companies, including GlaxoSmithKline, moved back into the antibacterials area and embraced a genomics-derived, target-based approach to screen for new classes of drugs with novel modes of

  8. Risks of Convulsion and Aseptic Meningitis following Measles-Mumps-Rubella Vaccination in the United Kingdom

    Microsoft Academic Search

    E. Miller; N. Andrews; J. Stowe; A. Grant; P. Waight; B. Taylor

    2007-01-01

    Measles-mumps-rubella (MMR) vaccines containing the Urabe strain of mumps were withdrawn in the United Kingdom in 1992 following demonstration of an increased risk of aseptic meningitis 15-35 days after vaccination. Following introduction of a replacement MMR vaccine (Priorix; GlaxoSmithKline, London, United Kingdom) in 1998, active surveillance of aseptic meningitis and convulsion was established to evaluate the risk associated with the

  9. The Adam Smith Page

    NSDL National Science Digital Library

    Harpham, Edward J.

    1998-01-01

    Edward J. Harpham, Associate Professor of Government and Political Economy at the University of Texas at Dallas, developed this new site to promote the study of the moral, political, and economic ideas of Adam Smith. Anyone with an interest in Smith's ideas will find numerous resources of interest. Perhaps the most useful are Harpham's updated lists of new and forthcoming scholarly articles and books on Smith. Students will also benefit from the comprehensive bibliography of secondary works, brief commentaries on Smith's works, and the collection of related links.

  10. Steiner ratio typeset December 5, 1994 Smith & Smith Warren D. Smith

    E-print Network

    Smith, J. MacGregor

    Steiner ratio typeset December 5, 1994 Smith & Smith Warren D. Smith 3 wds@research.nj.nec.com J. MacGregor Smith y jmsmith@umaecs.edu December 5, 1994 Abstract --- The ``Steiner minimal tree'' (SMT. This is a companion paper to D­Z. Du and W.D.Smith: Three disproofs of the Gilbert­Pollak Steiner ratio conjecture

  11. Dean of Libraries Steven Smith

    E-print Network

    Wang, Xiaorui "Ray"

    Dean of Libraries Steven Smith Development Director Erin Horeni-Ogle Associate Dean for Collections Dean Rita Smith Assessment Business Services Community Learning Services & Diversity Programs Hodges Library Council (Advisory) #12;Dean Steven Smith Head, Special Collections Jennifer Beals Special

  12. An Atlas of K-Line Spectra for Cool Magnetic CP Stars: The Wing-Nib Anomaly (WNA)

    NASA Astrophysics Data System (ADS)

    Cowley, C. R.; Hubrig, S.; Kamp, I.

    2006-04-01

    We present a short atlas illustrating the unusual Ca II K-line profiles in upper main-sequence stars with anomalous abundances. Slopes of the profiles for 10 cool, magnetic chemically peculiar (CP) stars change abruptly at the very core, forming a deep ``nib.'' The nibs show the same or nearly the same radial velocity as the other atomic lines. The near wings are generally more shallow than in normal stars. In three magnetic CP stars, the K lines are too weak to show this shape, although the nibs themselves are arguably present. The Ca II H lines also show deep nibs, but the profiles are complicated by the nearby, strong H? absorption. The K-line structure is nearly unchanged with phase in ? CrB and ? Cir. Calculations, including NLTE, show that other possibilities in addition to chemical stratification may yield niblike cores.

  13. Smith Tackles Oakland Unified

    ERIC Educational Resources Information Center

    Mellon, Ericka

    2011-01-01

    As a 20-something, Anthony "Tony" Smith had fulfilled one dream: playing professional football for the Green Bay Packers and the San Francisco 49ers. Next up, he thought, was law school, but a former mentor reminded him that he is a teacher. Smith never became a classroom teacher, but his background in sports--where he learned the power of…

  14. C. E. Smith, Page 1 of 2 Cartney E. Smith

    E-print Network

    Bashir, Rashid

    C. E. Smith, Page 1 of 2 Cartney E. Smith cesmith5@illinois.edu Education University of Illinois, C. E. Smith, K. Kim, H. Kong, "Tailoring Polymersome Bilayer Permeability Improves Enhanced. Vega L., M. K. Lee, J. H. Jeong, C. E. Smith, K. Y. Lee, H. J. Chung, D. E. Leckband, H. Kong

  15. Curriculum Vitae -Smith, J.L. 1 JULIETTE L. SMITH

    E-print Network

    Maa, Jerome P.-Y.

    Curriculum Vitae - Smith, J.L. 1 JULIETTE L. SMITH Virginia Institute of Marine Science / College Vitae - Smith, J.L. 2 MAJOR RESEARCH INTERESTS My research interests focus at the interface between-Reviewed *co-first authorship 1. Tong, M., *Smith, J.L., Richlen, M.L., Steidinger, K., Kulis, D., Fux, E

  16. Andrew James Smith The Thesis Committee for Andrew James Smith

    E-print Network

    Yang, Zong-Liang

    Copyright by Andrew James Smith 2012 #12;The Thesis Committee for Andrew James Smith certifies Supervisor: #12;OBSERVATIONS AND MODELS OF VENTING AT DEEPWATER GULF OF MEXICO VENTS by Andrew James Smith, B AND MODELS OF VENTING AT DEEPWATER GULF OF MEXICO VENTS Andrew James Smith, M.S.Geo.Sci. The University

  17. Aaron Lee Smith The Dissertation Committee for Aaron Lee Smith

    E-print Network

    John, Lizy Kurian

    Copyright by Aaron Lee Smith 2009 #12;The Dissertation Committee for Aaron Lee Smith certifies Compilation by Aaron Lee Smith, B.A., M.S. Dissertation Presented to the Faculty of the Graduate School thank my family for their encouragement. Aaron Lee Smith The University of Texas at Austin December 2009

  18. Smith et al Supporting Information

    E-print Network

    Jarvis, Erich D.

    Smith et al 1 Supporting Information for Smith et al. 2006, PLoS Computational Biology 2:e161-hyperpallium apicale; HF-hippocampal formation, and M-mesopallium. #12;Smith et al 2 FigureS2,nolinkswerefoundbetweenelectrodesindifferentbirds,andnolinkswerefoundintothesoundstimulusvariable. CombinedAnalysisofAllBirds'ElectrodesPlusSound #12;Smith et al 3 Analysis of Data from Subsections

  19. Adam Smith's stages of history

    Microsoft Academic Search

    Anthony Brewer

    2008-01-01

    The purpose of this paper is to examine Smith's four stages theory of history as an account of economic and social development, with an emphasis on the arguments and evidence he used to support it. In his biographical account of Smith's life, his friend Dugald Stewart described Smith’s method as 'conjectural history', initiating a debate which has continued ever since.

  20. The Relevance of Adam Smith

    NSDL National Science Digital Library

    The Federal Reserve Bank of Richmond explores the relevance of eighteenth-century economist Adam Smith in today's world. Quoting heavily from Smith's famous work The Wealth of Nations, this article summarizes many of Smith's main themes and ideas, and attempts to prove that Smith's "ideas have become so thoroughly absorbed into our intellectual heritage that they are no longer identifiable as having originated with Adam Smith."

  1. SOLAR CYCLE VARIABILITY AND SURFACE DIFFERENTIAL ROTATION FROM Ca II K-LINE TIME SERIES DATA

    SciTech Connect

    Scargle, Jeffrey D.; Worden, Simon P. [NASA Ames Research Center, Moffett Field, CA, 94035 (United States); Keil, Stephen L. [National Solar Observatory, P.O. Box 57, Sunspot, NM 88349 (United States)

    2013-07-01

    Analysis of over 36 yr of time series data from the NSO/AFRL/Sac Peak K-line monitoring program elucidates 5 components of the variation of the 7 measured chromospheric parameters: (a) the solar cycle (period {approx} 11 yr), (b) quasi-periodic variations (periods {approx} 100 days), (c) a broadband stochastic process (wide range of periods), (d) rotational modulation, and (e) random observational errors, independent of (a)-(d). Correlation and power spectrum analyses elucidate periodic and aperiodic variation of these parameters. Time-frequency analysis illuminates periodic and quasi-periodic signals, details of frequency modulation due to differential rotation, and in particular elucidates the rather complex harmonic structure (a) and (b) at timescales in the range {approx}0.1-10 yr. These results using only full-disk data suggest that similar analyses will be useful for detecting and characterizing differential rotation in stars from stellar light curves such as those being produced by NASA's Kepler observatory. Component (c) consists of variations over a range of timescales, in the manner of a 1/f random process with a power-law slope index that varies in a systematic way. A time-dependent Wilson-Bappu effect appears to be present in the solar cycle variations (a), but not in the more rapid variations of the stochastic process (c). Component (d) characterizes differential rotation of the active regions. Component (e) is of course not characteristic of solar variability, but the fact that the observational errors are quite small greatly facilitates the analysis of the other components. The data analyzed in this paper can be found at the National Solar Observatory Web site http://nsosp.nso.edu/cak{sub m}on/, or by file transfer protocol at ftp://ftp.nso.edu/idl/cak.parameters.

  2. Adam Smith and dependency.

    PubMed

    Ozler, Sule

    2012-06-01

    The focus of this paper is the works and life of Adam Smith, who is widely recognized as the father and founder of contemporary economics. Latent content analysis is applied to his seminal text in economics, An Inquiry into the Nature and Causes of the Wealth of Nations (1776). The results reveal that Smith considers dependence on others a problem and sees the solution to this problem in impersonalized interdependence. In addition, his views on social dependency and personal dependency, reflected in his Lectures on Jurisprudence (1963) and The Theory of Moral Sentiments (1759), are analyzed. This analysis suggests a central tension between dependence and independence in Smith's writings. The personal dependency patterns he exhibited in his life, which also suggest a tension between dependence and independence, are identified through a reading of his biographies. Based on insights from psychoanalytic literature, this paper proposes that developing the ideas in the Wealth of Nations was part of Smith's creative solution to this tension. In particular, his solution to one individual's dependence on another was through a system of impersonalized interdependence. In other words, Smith defended against his personal dependence through his economic theorizing. PMID:22712591

  3. 088 MARTIN HALL CLARICE SMITH

    E-print Network

    Anlage, Steven

    GARAGE 202 088 MARTIN HALL CLARICE SMITH PERFORMING ARTS CENTER 386 LEFRAK 038 SCHOOL OF PUBLIC HEALTH PRACTICE COMPLEX SHIPLEY FIELD AT BOB "TURTLE" SMITH STADIUM 159 COMMONS 6 975 COMMONS 5 974 SUSQUEHANNA

  4. Director HR Andrew J Smith

    E-print Network

    Liley, David

    Director HR Andrew J Smith Associate Director HR Shared Services Miya Chiba Associate Director Payroll Officer John Smith Systems & Project Analyst Blair Jordan HR Reporting Analyst Yana Zhang Manager

  5. Curriculum Vitae Douglas E. Smith

    E-print Network

    Smith, Douglas E.

    6/2014 Curriculum Vitae Douglas E. Smith ADDRESS Department of Physics, University of California Foundation Fellowship, 2003 · Beckman Young Investigator Award, 2003 #12;Doug Smith CV 7/2014 2 · Searle.E. Smith Physical Review Letters 112, 248101 (2014) - Highlighted by a perspective in Science: Yann R

  6. STEPHEN SMITH William Dawson Scholar

    E-print Network

    Barthelat, Francois

    STEPHEN SMITH William Dawson Scholar D E G R E E S D. Phil. (Oxford University) 1992 · LLB (Toronto S E A R C H ) tephen Smith is interested in the moral dimensions of the law, which does not merely. Professor Smith has focused much of his research on private law, and in particular the law of contract

  7. Copyright 2005 Veronica Susanne Smith

    E-print Network

    Washington at Seattle, University of

    Copyright 2005 Veronica Susanne Smith #12;Evaluating Spatial Normalization Methods for the Human Brain Veronica Susanne Smith A thesis submitted in partial fulfillment of the requirements for the Human Brain Veronica Susanne Smith Chair of the Supervisory Committee: Professor Linda S. Shapiro

  8. Kevin Smith Sutherland House 234

    E-print Network

    Bordenstein, Seth

    Kevin Smith Sutherland House 234 PMB 3342 Nashville, TN 37235 January 27, 2010 Mr. Scott at Kevin.m.smith@vanderbilt.edu or by phone at (543)3843909. Thank you for your consideration. Sincerely, Kevin Smith The cover letter needs to be in business letter format...this includes

  9. George Smith, Department of Materials,

    E-print Network

    Paxton, Anthony T.

    George Smith, Department of Materials, Oxford University, Parks Road, Oxford OX1 3PH UK Email: george.smith@materials.ox.ac.uk URL: www.materials.ox.ac.uk The aims of the Department of Materials experienced one of the most successful years in its 46-year history, says head of department George Smith. Top

  10. Presented by Jeremy C. Smith

    E-print Network

    Presented by Biosystems Jeremy C. Smith Center for Molecular Biophysics Biosciences Division #12;2 Managed by UT-Battelle for the U.S. Department of Energy Smith_Biosystems_SC10 Simulation model and cellulose Length-scale1 nm 1 m * L. Petridis and J. C. Smith (2009), "A molecular mechanics force field

  11. A Neural Smith Chart Application

    Microsoft Academic Search

    M. F. Caglar; F. Gunes

    2006-01-01

    The manual analysis and design of microwave circuits are generally tedious and error prone. The Smith chart provides a very useful graphical tool to these problems. A great deal of knowledge can be acquired from a Smith chart e.g. standing wave ratio, single and double stub tunings and much more. Although Smith charts are valuable and contain significant amount of

  12. CONTACT INFORMATION Sharon Smith

    E-print Network

    CONTACT INFORMATION Sharon Smith Director, Advanced Technology Lockheed Martin sharon of two respected leaders in industry and academia. Rice conducts an average of $30 million per year for materials, electronics, energy, security and defense. Through LANCER, Lockheed Martin engineers will pair

  13. Evaluation of effects of T and N type calcium channel blockers on the electroencephalogram recordings in Wistar Albino Glaxo/Rij rats, an absence epilepsy model

    PubMed Central

    Durmus, Nedim; Gültürk, Sefa; Kaya, Tijen; Demir, Tuncer; Parlak, Mesut; Altun, Ahmet

    2015-01-01

    Objectives: It is suggested that excessive calcium entry into neurons is the main triggering event in the initiation of epileptic discharges. We aimed to investigate the role of T and N type calcium channels in absence epilepsy experimental model. Materials and Methods: Wistar Albino Glaxo/Rij (WAG/Rij) rats (12–16 weeks old) were randomly allocated into four groups; sham, mibefradil (T type calcium channel blocker), w-Conotoxin MVIIA (N type calcium channel blocker), and mibefradil + w-Conotoxin MVIIA. Beta, alpha, theta, and delta wave ratios of EEG recordings and frequency and duration of spike wave discharges (SWDs) were analyzed and compared between groups. Results: Beta and delta recording ratios in 1 ?M/5 ?l mibefradil group was significantly different from basal and other dose-injected groups. Beta, alpha, and theta recordings in 0.2 ?M/5 ?l w-Conotoxin MVIIA group was significantly different from basal and other dose-injected groups. In w-Conotoxin MVIIA after mibefradil group, beta, alpha, and theta recording ratios were significantly different from basal and mibefradil group. Mibefradil and w-Conotoxin MVIIA significantly decreased the frequency and duration of SWDs. The decrease of frequency and duration of SWDs in mibefradil group was significantly different from w-Conotoxin MVIIA group. The frequency and duration of SWDs significantly decreased in w-Conotoxin MVIIA after mibefradil group compared with basal, mibefradil, and w-Conotoxin MVIIA groups. Conclusions: We concluded that both T and L type calcium channels play activator roles in SWDs and have positive effects on frequency and duration of these discharges. These results are related with their central effects more than peripheral effects. PMID:25821308

  14. Portrait of Waldo Smith

    NASA Astrophysics Data System (ADS)

    Spilhaus, Fred

    2009-01-01

    In 1944, Waldo Smith was looking for a place where he could make a difference. He had taught in universities in the United States and Turkey, and he had worked as an engineer in the field of hydrology in the United States. Somehow, a chance meeting with John Adam Fleming, AGU's long-time General Secretary, led to Waldo's becoming the first executive officer employed by the Union. That, in turn, brought him the opportunity to make a difference.

  15. Sophia Smith Collection

    NSDL National Science Digital Library

    As part of the Five College Archives Digital Access Project (mentioned in the September 25, 1998 Scout Report), Smith College has digitized some of its archival holdings relating to women's history. The Website of the Sophia Smith Collection presents still more of the Smith College holdingsof "manuscripts, photographs, periodicals and other primary sources in women's history." The site includes brief descriptions of over 300 manuscript collections, lesson plans for using primary source materials, links to additional women's history resources, and selected digital images. A permanent exhibition, Agents of Social Change, showcases some materials online. The exhibit contains pictures and digitized documents on eight 20th-century women and organizations working for women's rights. Visitors will find items such as a brochure about the National Congress of Neighborhood Women (NCNW), a grassroots feminist organization; a 1980 photo of an NCNW march on New York City Hall; Gloria Steinem photographed at the Ms. office in 1983; and fan mail to Steinem after a TV appearance.

  16. Smith-Lemli-Opitz-syndrome

    PubMed Central

    Gedam, Rachana; Shah, Ira; Ali, Uma; Ohri, Alpana

    2012-01-01

    Smith-Lemli-Opitz syndrome is an autosomal recessively inherited disorder. A severe defect in cholesterol biosynthesis has been identified leading to abnormally low plasma cholesterol levels and elevated levels of the cholesterol precursor 7-dehydrocholesterol, the result of deficiency of 7-dehydrocholesterol reductase. We describe one such child with Smith-Lemli-Opitz syndrome. This child had clinical features similar to Smith-Lemli-Opitz syndrome like facial dysmorphism and cardiac and renal anomalies with failure to thrive. PMID:23162303

  17. Getting to know Joseph Smith

    NSDL National Science Digital Library

    Bro. Davidson

    2010-06-09

    In these simple modules you will commit to memory 6 important dates in the life of Joseph Smith. Attempt to remember the date before clicking on the link directly under the picture. Write the dates in your journal and present the journal to Bro. Davidson for credit Joseph Smith was born in Sharon, Windsor county, Vermont in _____? Cute baby boy Birth date The first vision occurred in _____? first vision First vision date Moroni then visits the prophet in ____? Moroni Moroni visitations Joseph marries Emma ____? Emma Smith Marriage The church is officially reorganized in ____? Church restored Restoration Joseph and Hyrum martyred in ____? Martyrdom of Joseph Smith Martyrdom ...

  18. SMITH THEORY FOR ALGEBRAIC VARIETIES PETER SYMONDS

    E-print Network

    Symonds, Peter

    SMITH THEORY FOR ALGEBRAIC VARIETIES PETER SYMONDS Abstract.We show how an approach to Smith Theory about group actions on * *CW. 1.Introduction Peter May described in [8] a version of Smith Theory based on Bredon cohomolo

  19. Smith Theory Revisited William G. Dwyer

    E-print Network

    Wilkerson, Clarence

    Smith Theory Revisited William G. Dwyer Clarence W. Wilkerson* 1 Introduction In the late 1930's, P. A. Smith began the investigation. This thread has continued now for almost fifty years. Smith was successful in calculating the cohomology

  20. Page 1 of 7 DEBORAH K. SMITH

    E-print Network

    Smith, Deborah K.

    Smith - CV Page 1 of 7 DEBORAH K. SMITH Senior Scientist TEL.: (508) 289-2472 Department of Geology, and the Environment: Our Changing Oceans #12;Smith - CV Page 2 of 7 2011 NOAA OER Atlantic Basin Workshop, URI Coastal

  1. Genetics Home Reference: Smith-Magenis syndrome

    MedlinePLUS

    ... PubMed Recent literature OMIM Genetic disorder catalog Conditions > Smith-Magenis syndrome On this page: Description Genetic changes ... names Glossary definitions Reviewed December 2013 What is Smith-Magenis syndrome? Smith-Magenis syndrome is a developmental ...

  2. Adam Smith's Concept of Social Justice

    Microsoft Academic Search

    Matthew Braham

    2006-01-01

    Abstract ,This paper examines ,the concept of moral ,egalitarianism in Adam Smith’s corpus. I argue that it is precisely the idea of ‘equal moral worth’ that forms the nucleus of a ,theory of social justice that has generally thought to be absent in Smith’s corpus. Contrary to belief ,among ,many ,economists ,and libertarian philosophers, Smith’s idea of justice was not

  3. Expanded Plain TEX Steven Smith

    E-print Network

    Mintmire, John W.

    Expanded Plain TEX Sept 2004 2.8.4 Karl Berry Steven Smith #12;This manual documents the Eplain Berry. Steven Smith wrote the documentation for the commutative diagram macros. (He also wrote the macros.) Some additions/corrections by Adam Lewenberg. Permission is granted to make and distribute

  4. Near-coincident K-line and K-edge energies as ionization diagnostics for some high atomic number plasmas

    SciTech Connect

    Pereira, N. R. [Ecopulse, Inc., P.O. Box 528, Springfield, Virginia 22150 (United States); Weber, B. V.; Phipps, D. G.; Schumer, J. W. [Naval Research Laboratory, Washington, DC 20375 (United States); Seely, J. F. [Artep, Inc., 2922 Excelsior Springs Court, Ellicott City, Maryland 21042 (United States); Carroll, J. J. [Army Research Laboratory, Adelphi, Maryland 20873 (United States); Vanhoy, J. R. [United States Naval Academy, Annapolis, Maryland 21402 (United States); Slabkowska, K.; Polasik, M. [Faculty of Chemistry, Nicolaus Copernicus University, Gagarina 7, 87-100 Torun (Poland)

    2012-10-15

    For some high atomic number atoms, the energy of the K-edge is tens of eVs higher than the K-line energy of another atom, so that a few eV increase in the line's energy results in a decreasing transmission of the x-ray through a filter of the matching material. The transmission of cold iridium's Asymptotically-Equal-To 63.287 keV K{alpha}{sub 2} line through a lutetium filter is 7% lower when emitted by ionized iridium, consistent with an energy increase of {Delta}{epsilon} Asymptotically-Equal-To 10{+-}1 eV associated with the ionization. Likewise, the transmission of the K{beta}{sub 1} line of ytterbium through a near-coincident K-edge filter changes depending on plasma parameters that should affect the ionization. Systematic exploration of filter-line pairs like these could become a unique tool for diagnostics of suitable high energy density plasmas.

  5. SMITH THEORY FOR ALGEBRAIC VARIETIES PETER SYMONDS

    E-print Network

    Symonds, Peter

    SMITH THEORY FOR ALGEBRAIC VARIETIES PETER SYMONDS Abstract. We show how an approach to Smith varieties. 1. Introduction Peter May described in [8] a version of Smith Theory based on Bredon cohomology of the variety. We show how to generalize this to obtain a complex of projective coefficient systems. Thus Smith

  6. Sophia Smith Collection: Women's History Archives at Smith College

    NSDL National Science Digital Library

    2012-07-13

    The Sophia Smith Collection at Smith College was made possible under the guidance of its first director, Margaret Storrs Grierson. In 1946, it was named in honor of the founder of Smith College and it has grown to include over 650 different thematic collections. On this page, visitors can browse through their online image collections, oral histories, and exhibits. The oral histories are quite a treat, as they include 50 in-depth interviews which document the persistence and diversity of organizing for women in the United States. Additionally, this area contains interviews on population and reproductive health and conversations with student activists at Smith College. The Online Exhibits area includes nine thematic collections. One of the most interesting among them is the Girl Zines collection, which features independent magazines that address "third wave" feminism and sexuality. Finally, visitors can use the Finding Images section to look over 300 items that include political buttons, handicrafts, and cartoons.

  7. The making of I-BET762, a BET bromodomain inhibitor now in clinical development.

    PubMed

    Zhao, Yujun; Yang, Chao-Yie; Wang, Shaomeng

    2013-10-10

    Bromodomain and extra-terminal (BET) proteins belong to a class of proteins collectively called epigenetic "readers". BET bromodomains have emerged as promising drug targets for treatment of cancers, inflammatory diseases, and other medical conditions. GlaxoSmithKline scientists have successfully optimized a class of benzodiazepines as inhibitors of BET bromodomains, without any prior knowledge of identified molecular targets. It thus is possible to hit a target without aiming at it. The optimized lead compound I-BET762 is currently being evaluated in a phase I clinical trial for treatment of human cancer. PMID:24107192

  8. Clinical update of the AS04-Adjuvanted human Papillomavirus16\\/18 cervical cancer vaccine, cervarix®

    Microsoft Academic Search

    Tino F. Schwarz

    2009-01-01

    Persistent infection with human papillomavirus (HPV) is a necessary cause of cervical cancer, resulting annually in 274,000\\u000a deaths worldwide. Two prophylactic HPV vaccines are licensed in >100 countries, and immunization programs in young, adolescent\\u000a girls have been widely implemented. HPV-16\\/18 AS04-adjuvanted vaccine (Cervarix®; GlaxoSmithKline Biologicals, Rixensart,\\u000a Belgium) has demonstrated type-specific protection against the five most frequent cancer-causing types (16, 18,

  9. Cowboy Photographer: Erwin E. Smith

    NSDL National Science Digital Library

    While many are familiar with the romantic notion of the American cowboy as crafted by Frederic Remington and Charles M. Russell, few share intimate knowledge of a lesser known artist, Erwin E. Smith. This online exhibit, created by the Amon Carter Museum in Texas, seeks to rectify that situation through this extensive archive of photographs by Smith that capture the world of the cowboy around the turn of the 20th century. Smith grew up in Texas collecting prints of paintings by artists like George Catlin and Frederic Remington. He later ended up studying art with Lorado Taft at the Art Institute of Chicago, and then at the School of the Boston Museum of Fine Arts. Smith later moved back West, and between 1905 and 1912, he took thousands of photographs on ranches throughout Texas, New Mexico, and Arizona. The photographs available online here are divided into several main sections for convenient browsing, including Cowhand clothing, Rodeo, and Ranches. Along with a biography of Smith, the site also includes a glossary of terms used by cowboys and ranchers, as well as several teaching resources for educators.

  10. Towards robot audition Leslie S. Smith

    E-print Network

    Smith, Leslie S.

    Towards robot audition Leslie S. Smith Department of Computing Science and Mathematics, University in illumination, and auditory systems can detect changes in room reverberation. #12;2 Leslie S. Smith Another key

  11. The RB Language Jonathan M. Smith

    E-print Network

    ­­ ­­ The RB Language Jonathan M. Smith Distributed Systems Laboratory Department of Computer of an attempt to generate more practical examples of the scheme described by Smith and Maguire for ``competitive

  12. michael smith ornl bottlenecks and waiting points michael smith, tomomi sunayama*, w. raphael hix,

    E-print Network

    michael smith ornl bottlenecks and waiting points michael smith, tomomi sunayama*, w. raphael hix, galesburg, illinois, usa #12;michael smith ornl bottlenecks and waiting points nova and x-ray bursts in these explosions & should be identified for further study #12;michael smith ornl bottlenecks and waiting points

  13. Jo Ann Smith, PhD Page 1 JO ANN SMITH, PHD, CRA

    E-print Network

    Van Stryland, Eric

    Jo Ann Smith, PhD Page 1 JO ANN SMITH, PHD, CRA University of Central Florida College of Health, Orlando, FL 32816-1395 Office: (407) 823-3925 Fax: (407)823-5651 E-mail: Jo.Smith@ucf.edu I. EDUCATION Research (PEER) Group Consultant #12;Jo Ann Smith, PhD Page 2 2001 ­ 2006 Director, Center for Educational

  14. Dr. Peter Smith answers questions after his presentation on Sunday, Jan. 12. Smith was just one

    E-print Network

    Kaufman, Glennis A.

    Dr. Peter Smith answers questions after his presentation on Sunday, Jan. 12. Smith was just one Research, on Saturday. Dr. Peter Smith, Directory of the Bioinformatics Satellite Core at KUMC gave estimates strikes over 50% of individuals over the age of 85. On Sunday, Dr. Smith talked about using

  15. Updated 11/2013 Jimmy D. Smith

    E-print Network

    Updated 11/2013 Jimmy D. Smith Director, Integrated Nuclear Weapons Safety and Security, Strategic Systems Programs Mr. Smith is the Director for Integrated Nuclear Weapons Safety and Security within the U.S. Navy's Strategic Systems Programs. In this capacity, Mr. Smith serves as the senior advisor

  16. Nelson G. Hairston Frederick E. Smith

    E-print Network

    Jodice, Patrick

    Nelson G. Hairston Frederick E. Smith Lawrence B. Slobodkin Department of Zoology, The University of Michigan Founded the Department of Ecology & Evolution at Stony Brook University (NY) Frederick SmithFrederick Smith University of Michigan Moved on to Harvard #12;~1500 words Citations ­ more than 1500 "HSS

  17. SMITH NORMAL FORM AND LAPLACIANS DINO LORENZINI

    E-print Network

    Lorenzini, Dino J.

    SMITH NORMAL FORM AND LAPLACIANS DINO LORENZINI Abstract. Let M denote the Laplacian matrix of a graph G. Associated with G is a finite group (G), obtained from the Smith normal form of M, and whose /Im(M). This group can be computed in practice using the Smith normal form of M, as follows. Given any

  18. Math in Microbiology Hal L. Smith

    E-print Network

    Smith, Hal

    Math in Microbiology Hal L. Smith PSA 631 halsmith@asu.edu School of Mathematics and Statistics Arizona State University H.L.Smith (A.S.U.) Math in Microbiology Microbiology, January 2009 1 / 22 #12 for Nutrient 4 Bacteriophage and Bacteria in Chemostat 5 Food Chain H.L.Smith (A.S.U.) Math in Microbiology

  19. Arras User's Manual John B. Smith

    E-print Network

    North Carolina at Chapel Hill, University of

    Arras User's Manual TR85-036 1985 John B. Smith The University of North Carolina at Chapel Hill'S MANUAL John B. Smith Department or Computer Science University or North Carolina Chapel Hill, North Carolina 27514 Copyright© 1984 by John B. Smith #12;Starling ARRAS Note for those not using TUCC: The ARRAS

  20. Smith Theory Revisited William G. Dwyer

    E-print Network

    Wilkerson, Clarence

    Smith Theory Revisited William G. Dwyer Clarence W. Wilkerson \\Lambda 1 Introduction In the late 1930's, P. A. Smith began the investigation of the cohomological properties of a group G of prime order fifty years. Smith was successful in calculating the cohomology of the the fixed point sets

  1. Smith Theory Revisited William G. Dwyer

    E-print Network

    Wilkerson, Clarence

    Smith Theory Revisited William G. Dwyer Clarence W. Wilkerson 1 Introduction In the late 1930's, P. A. Smith began the investigation of the cohomological properties of a group G of prime order p. Smith was successful in calculating the cohomology of the the fixed point sets for involutions

  2. BOUNDS FOR SPECTRAL CLUSTERS HART F. SMITH

    E-print Network

    Smith, Hart F.

    Lq BOUNDS FOR SPECTRAL CLUSTERS HART F. SMITH Abstract. In these notes, we review recent results] establish the same estimates under the assumption that the metric is C1,1. It is known by examples of Smith to the wave equation. The author was supported in part by NSF grant DMS-0140499. 1 #12;2 HART F. SMITH

  3. The Coverage of Operational Scott F. Smith

    E-print Network

    Smith, Scott F.

    The Coverage of Operational Semantics Scott F. Smith Department of Computer Science The Johns (Talcott 1989), types and objects (Gordon and Rees 1996), and distributed objects (Agha, Mason, Smith text can 1 #12;2 Smith distinguish the two. This program text can be viewed as a particular "test

  4. RANDALL KNOWLES SMITH High Energy Astrophysics Division

    E-print Network

    ., Foster, Adam, Smith, Randall K., Kat- suda, Satoru, Yoshii, Rie, 2012, Astrophysical Journal, 749, 137 9RANDALL KNOWLES SMITH High Energy Astrophysics Division Smithsonian Astrophysical Observatory, MS 2 / Edited Proceedings Handbook of X-ray Astronomy, K. A. Arnaud, R. K. Smith, & A. Siemiginowska 2011

  5. Rediscovering Major N. Clark Smith.

    ERIC Educational Resources Information Center

    Buckner, Reginald T.

    1985-01-01

    Historians of American music education have yet to recognize a Black music educator as important and worthy of observation. This article discusses a candidate--Major Nathaniel Clark Smith, a little-known Black music educator, composer of more than a hundred works, businessman, humanitarian, and teacher of numerous big-name jazz musicians. (RM)

  6. Smith Mammal Body Mass Data

    NSDL National Science Digital Library

    Ethel Stanley (Beloit College; Biology)

    2009-01-10

    Data compiled on body mass information for 5731 mammalian species. Felisa A. Smith, S. Kathleen Lyons, S. K. Morgan Ernest, Kate E. Jones, Dawn M. Kaufman, Tamar Dayan, Pablo A. Marquet, James H. Brown, and John P. Haskell. 2003. Body mass of late Quaternary mammals. Ecology 84:3403

  7. Deborah K. Smith Senior Scientist

    E-print Network

    Smith, Deborah K.

    scan sonar images, 25o -29o N, J. Volcan. and Geotherm. Res., 67, 233-262, 1995. Smith, D. K., S. E identification in side scan sonar and bathymetry from the Mid-Atlantic Ridge using 2-D wavelet analysis, Mar on Earth and "Pancake" domes on Venus, J. Volcan. and Geotherm. Res., 73, 47-64, 1996. Head, J. W., L

  8. The same face of the two Smiths: Adam Smith and Vernon Smith

    Microsoft Academic Search

    Maria Pia Paganelli

    2011-01-01

    Going from personal to impersonal exchange seems to be a relevant feature that allows humans to develop complex societies and grow prosperous. Adam Smith's idea of moral imagination, embodied in the impartial spectator and achieved through sympathy, may integrate and complement today's evolutionary biology and experimental economic explanations, providing the missing key as to how we generate and internalize those

  9. Econophysical visualization of Adam Smith’s invisible hand

    NASA Astrophysics Data System (ADS)

    Cohen, Morrel H.; Eliazar, Iddo I.

    2013-02-01

    Consider a complex system whose macrostate is statistically observable, but yet whose operating mechanism is an unknown black-box. In this paper we address the problem of inferring, from the system’s macrostate statistics, the system’s intrinsic force yielding the observed statistics. The inference is established via two diametrically opposite approaches which result in the very same intrinsic force: a top-down approach based on the notion of entropy, and a bottom-up approach based on the notion of Langevin dynamics. The general results established are applied to the problem of visualizing the intrinsic socioeconomic force-Adam Smith’s invisible hand-shaping the distribution of wealth in human societies. Our analysis yields quantitative econophysical representations of figurative socioeconomic forces, quantitative definitions of “poor” and “rich”, and a quantitative characterization of the “poor-get-poorer” and the “rich-get-richer” phenomena.

  10. An interlaboratory transfer of a multi-analyte assay between continents.

    PubMed

    Georgiou, Alexandra; Dong, Kelly; Hughes, Stephen; Barfield, Matthew

    2015-01-01

    Alex has worked at GlaxoSmithKline for the past 15 years and currently works within the bioanalytical and toxicokinetic group in the United Kingdom. Alex's role in previous years has been the in-house support of preclinical and clinical bioanalysis, from method development through to sample analysis activities as well as acting as PI for GLP bioanalysis and toxicokinetics. For the past two years, Alex has applied this analytical and regulatory experience to focus on the outsourcing of preclinical bioanalysis, toxicokinetics and clinical bioanalysis, working closely with multiple bioanalytical and in-life CRO partners worldwide. Alex works to support DMPK and Safety Assessment outsourcing activities for GSK across multiple therapeutic areas, from the first GLP study through to late stage clinical PK studies. Transfer and cross-validation of an existing analytical assay between a laboratory providing current analytical support, and a laboratory needed for new or additional support, can present the bioanalyst with numerous challenges. These challenges can be technical or logistical in nature and may prove to be significant when transferring an assay between laboratories in different continents. Part of GlaxoSmithKline's strategy to improve confidence in providing quality data, is to cross-validate between laboratories. If the cross-validation fails predefined acceptance criteria, then a subsequent investigation would follow. This may also prove to be challenging. The importance of thorough planning and good communication throughout assay transfer, cross-validation and any subsequent investigations is illustrated in this case study. PMID:25932517

  11. S-0139 (Shionogi).

    PubMed

    Wu-Wong, J Ruth

    2002-07-01

    Shionogi and GlaxoSmithKline (GSK), as the joint venture company Shionogi-GlaxoSmithKline Pharmaceuticals LLC, are developing S-0139 (SB-737004), an endothelin-A (ETA) antagonist, for the potential treatment of hemorrhagic and ischemic stroke [223386], [252007], [426822], [426830]. By 1999, the compound was in phase II trials in Japan for stroke [348554]; phase II trials were ongoing in March 2002 [446957]. As of May 2000, Shionogi was preparing to develop the drug in the US and Europe [370602]. As of May 2001, a phase I European trial was in preparation [410912]; which was underway by November 2001 [429990]. In July 2001, Shionogi and GSK signed a letter of intent to create a joint venture that was initially to have exclusive rights to develop and commercialize four compounds contributed by Shionogi and one by GSK, including S-0139 14167621. The agreement wasfinalized in October 2001 [426569], [426822]. In August 1999, Lehman Brothers gave S-0139 a 10% probability of reaching the market with an expected launch in 2005. Sales were expected to peak at US $50 million in 2012 [349228]. PMID:12186266

  12. Fukushima to receive Smith Medal

    NASA Astrophysics Data System (ADS)

    The 1990 Waldo E. Smith Medal for extraordinary service to geophysics will be given to Naoshi Fukushima, who earned an international reputation for his pioneering work in geomagnetic disturbance and ionospheric electric currents. Now retired from the University of Tokyo, Japan, Fukushima is being cited for his public service to international geophysics, and, in particular, his contributions to the International Association of Geomagnetism and Aeronomy, of which he was Secretary General from September 1975 to August 1983.The Smith Medal will be presented as part of the AGU Fall Meeting Honors Night festivities, Wednesday, December 5, in San Francisco, Calif. Three James B. Macelwane Medals, the John Adam Fleming Medal, and the Maurice Ewing Medal will also be presented (see Eos, February 20, 1990, p. 294).

  13. Street & Smith's Preservation Access Project

    NSDL National Science Digital Library

    For thousands of Americans throughout the 19th and early 20th centuries, dime novels and pulp magazines were their first experiences with the emerging world of mass-produced material culture. One such purveyor was the Street & Smith publishing house, which began in 1855 and published a wide variety of popular literature (such as homemaking magazines, comics, and dime novels) for over 100 years. These products didn't often have a great deal of originality, as the company viewed fiction as a commodity, and editors dictated plots and characters to writers, a list that included Horatio Alger, Upton Sinclair, and Jack London. This Web site, an online exhibit presented by the Syracuse University Library, pays homage to this publishing house with a number of scanned digitized images of the Street & Smith dime novels, a cover art gallery, and a collection of images immortalizing that most famous comic strip character, the Yellow Kid.

  14. GPU Accelerated Smith-Waterman

    SciTech Connect

    Liu, Y; Huang, W; Johnson, J; Vaidya, S

    2006-02-08

    We present a novel hardware implementation of the double affine Smith-Waterman (DASW) algorithm, which uses dynamic programming to compare and align genomic sequences such as DNA and proteins. We implement DASW on a commodity graphics card, taking advantage of the general purpose programmability of the graphics processing unit to leverage its cheap parallel processing power. The results demonstrate that our system's performance is competitive with current optimized software packages.

  15. An interview with Austin Smith.

    PubMed

    Vicente, Catarina

    2015-07-01

    Austin Smith is a stem cell and developmental biologist, who has dedicated his career to the study of pluripotency, stem cell renewal and differentiation. He is currently the Director of the Wellcome Trust MRC Cambridge Stem Cell Institute at the University of Cambridge, UK. We met him there to discuss his research and interests, as well as his role as an editor for Development. PMID:26130753

  16. William Smith (1769-1839)

    NSDL National Science Digital Library

    This brief history of William Smith, who initiated the Principle of Faunal Succession, covers his early education, his employment as an assistant surveyor to Edward White, and his time as construction supervisor of the Somerset Canal in southwestern England. The text explains his production of a geological map of England and final recognition in 1831, when he received the Wollaston Medal, the highest honor awarded each year for outstanding achievement in geology by the Geological Society of London.

  17. McKoOL SMITH Benjamin Levi

    E-print Network

    Baker, R. Jacob

    McKoOL SMITH Benjamin Levi Direct Dial: (202) 370-8320 blevi@McKooISmith.com VIA HAND DELf Complaint for Commission use pursuant to 19 C.F.R. § 2 10.4(f)(2); McKool Smith A ProfessiOllll1 Corpora. Sincerely, ~I,..; Benjamin Levi Enclosures: 2 #12;McKoOL SMITH Benjamin Levi Direct Dial: (202) 370

  18. The visible Smith-Purcell radiation search

    SciTech Connect

    Fernow, R.C.; Kirk, H.G.; Ulc, S. Wang, X.

    1994-03-01

    We report here the results of an experiment at the Accelerator Test Facility at Brookhaven National Laboratory to search for the production of visible radiation from the Smith-Purcell effect using a 3 MeV electron beam. After running the experiment under a variety of conditions we were unable to isolate a definite signal from Smith-Parcell effect. Any Smith-Purcell signal present in the measured radiation was less than 10% of the background signal.

  19. Richard Smith, Director smith@sfu.ca Adam Holbrook, Associate Director

    E-print Network

    CONTACT Richard Smith, Director smith@sfu.ca Adam Holbrook, Associate Director jholbroo Clayman Andrew Feenberg Andy Hira Adam Holbrook Martin Laba Brian Lewis Elicia Maine Stelvia Matos Ian McCarthy Roman Onufrijchuk Richard Smith David Zandvliet RESEARCHERS & ASSOCIATES Nancy Duxbury Gordon Gow

  20. THE SMITH COLLEGE DIPLOMA PROBLEM Ira M. Gessel

    E-print Network

    Gessel, Ira M.

    THE SMITH COLLEGE DIPLOMA PROBLEM Ira M. Gessel Department of Mathematics Brandeis University]: At Smith College, the graduation exercises traditionally proceed as follows: Although each diploma is made Smith College diploma problem, we explain the connection between

  1. Smith Normal Form a possible basis for an

    E-print Network

    Henkel, Werner

    Smith Normal Form ­ a possible basis for an SVD ­ like code construction? (Semester Project I) Name.7 The Smith Normal Form . . . . . . . . . . . . . . . . . . . . . . . 12 3 Detailed treatment of the possibilities to use Smith's Normal Form for coding 14 3.1 Introduction

  2. THE SMITH COLLEGE DIPLOMA PROBLEM Ira M. Gessel

    E-print Network

    Gessel, Ira M.

    THE SMITH COLLEGE DIPLOMA PROBLEM Ira M]: At Smith College, the graduation exercises traditionally proceed as follow* *s: Although each diploma excedances, which are values of i for which i Smith College diploma problem

  3. Genetics Home Reference: Smith-Lemli-Opitz syndrome

    MedlinePLUS

    ... PubMed Recent literature OMIM Genetic disorder catalog Conditions > Smith-Lemli-Opitz syndrome On this page: Description Genetic ... names Glossary definitions Reviewed July 2007 What is Smith-Lemli-Opitz syndrome? Smith-Lemli-Opitz syndrome is ...

  4. On the Line with Ray Smith.

    ERIC Educational Resources Information Center

    Educom Review, 1996

    1996-01-01

    Presents an interview with Ray Smith, Chairman and Chief Executive Officer of Bell Atlantic Corporation. As a member of several advisory boards (Business Roundtable, Library of Congress, Committee on Arts and Humanities, and National Information Infrastructure), Smith offers his view on the future of the telecommunications industry,…

  5. Constructivism and Development: Reply to Smith's Commentary.

    ERIC Educational Resources Information Center

    Muller, Ulrich; Sokol, Bryan; Overton, Willis F.

    1998-01-01

    Replies to commentary regarding authors' earlier article proposing a modified constructivist account of origins of mental representation. Elaborates on Smith's discussion contrasting empiricist and constructivist approaches. Discusses Smith's restatement of Piaget's position in terms of levels of representational capacities and replies to specific…

  6. Adam Smith and the Rhetoric of Style.

    ERIC Educational Resources Information Center

    Moran, Michael G.

    Historians of rhetoric have generally accepted the view that Adam Smith rejected the principles of classical rhetoric. However, while there can be no doubt that Smith greatly truncated the five classical arts of rhetoric (invention, arrangement, style, memory, and delivery) by reducing his concerns largely to style and arrangement, he did not…

  7. The Treatment of Smith's Invisible Hand

    ERIC Educational Resources Information Center

    Wight, Jonathan B.

    2007-01-01

    Adam Smith used the metaphor of an invisible hand to represent the instincts of human nature that direct behavior. Moderated by self-control and guided by proper institutional incentives, actions grounded in instincts can be shown to generate a beneficial social order even if not intended. Smith's concept, however, has been diluted and distorted…

  8. The hidden theology of Adam Smith

    Microsoft Academic Search

    Lisa Hill

    2001-01-01

    This paper contests late readings of Adam Smith's 'invisible hand' as an essentially secular device. It is argued that Smith's social and economic philosophy is inherently theological and that his entire model of social order is logically dependent on the notion of God's action in nature. It will be shown that far from being a purely secular, materialist or evolutionist

  9. J. E. Smith C. M. Smith C. L. Hunter An experimental analysis of the effects of herbivory and nutrient

    E-print Network

    Smith, Jennifer E.

    REPORT J. E. Smith á C. M. Smith á C. L. Hunter An experimental analysis of the effects become increasingly common (Smith et al. 1981; Hughes et al. 1987; Lapointe 1997; McClanahan et al. 1999 lead to substantial changes in ben- thic community structure (Smith et al. 1981; Littler and Littler

  10. SMITH IDEALS OF STRUCTURED RING SPECTRA Abstract. Pursuing ideas of Jeff Smith, we develop a homotopy theory of

    E-print Network

    Hovey, Mark

    SMITH IDEALS OF STRUCTURED RING SPECTRA MARK HOVEY Abstract. Pursuing ideas of Jeff Smith, we develop a homotopy theory of ideals of monoids in a symmetric monoidal model category. This includes Smith ideals of structured ring spectra and of differential graded algebras. Such Smith ideals

  11. Smith receives top teaching honors in Spartanburg District 2 Christopher Smith '06, band director at Chesnee Middle School and

    E-print Network

    Smith receives top teaching honors in Spartanburg District 2 Christopher Smith '06, band director Spartanburg School District 2 Teacher of the Year. Smith, initially selected as Chesnee Middle School administrators described Smith as a model teacher who goes far beyond the call of duty. "Chris is extremely

  12. Smith normal forms of incidence matrices

    NASA Astrophysics Data System (ADS)

    Sin, Peter

    2013-07-01

    A brief introduction is given to the topic of Smith normal forms of incidence matrices. A general discussion of techniques is illustrated by some classical examples. Some recent advances are described and the limits of our current understanding are indicated.

  13. Wendy Ryan, Nolan Doesken, and Rebecca Smith

    E-print Network

    Colorado DNR (state and local) Denver Water and other smaller water providers Northwest Council Colorado River Water Conservation District Northern Colorado Water Conservancy District EXCEL EnergyWendy Ryan, Nolan Doesken, and Rebecca Smith Colorado Climate Center #12; 1977: Systematic

  14. The Two Faces of Adam Smith

    Microsoft Academic Search

    Vernon L. Smith

    1998-01-01

    Adam Smith’s two major works are based on apparently contradictory themes in human nature: noncooperative self-interest and other-regarding sympathy. These views are not contradictory if we distinguish impersonal market exchange and personal exchange. Noncooperative behavior in the former maximizes the gains from exchange, the basis of specialization and wealth creation. Cooperative behavior in personal exchange is based on reciprocity—trading gifts,

  15. The Devil in Mr. Smith: A Conversation with Jonathan Z. Smith

    ERIC Educational Resources Information Center

    Smith, Jonathan Z.; Pearson, Thomas; Gallagher, Eugene V.; Jensen, Tim; Fujiwara, Satoko

    2014-01-01

    This interview was recorded in November 2012 in Jonathan Z. Smith's Hyde Park graystone. Professor Smith offers insights into how he thinks about his classroom teaching and his students' learning through descriptions of various assignments and classroom activities he has developed over more than forty years of teaching. The discussion…

  16. Chromospheric Variability: Analysis of 36 years of Time Series from the National Solar Observatory/Sacramento Peak Ca II K-line Monitoring Program

    NASA Technical Reports Server (NTRS)

    Scargle, Jeffrey D.; Keil, Stephen L.; Worden, Simon P.

    2014-01-01

    Analysis of more than 36 years of time series of seven parameters measured in the NSO/AFRL/Sac Peak K-line monitoring program elucidates five elucidates five components of the variation: (1) the solar cycle (period approx. 11 years), (2) quasi-periodic variations (periods approx 100 days), (3) a broad band stochastic process (wide range of periods), (4) rotational modulation, and (5) random observational errors. Correlation and power spectrum analyses elucidate periodic and aperiodic variation of the chromospheric parameters. Time-frequency analysis illuminates periodic and quasi periodic signals, details of frequency modulation due to differential rotation, and in particular elucidates the rather complex harmonic structure (1) and (2) at time scales in the range approx 0.1 - 10 years. These results using only full-disk data further suggest that similar analyses will be useful at detecting and characterizing differential rotation in stars from stellar light-curves such as those being produced by NASA's Kepler observatory. Component (3) consists of variations over a range of timescales, in the manner of a 1/f random noise process. A timedependent Wilson-Bappu effect appears to be present in the solar cycle variations (1), but not in the stochastic process (3). Component (4) characterizes differential rotation of the active regions, and (5) is of course not characteristic of solar variability, but the fact that the observational errors are quite small greatly facilitates the analysis of the other components. The recent data suggest that the current cycle is starting late and may be relatively weak. The data analyzed in this paper can be found at the National Solar Observatory web site http://nsosp.nso.edu/cak_mon/, or by file transfer protocol at ftp://ftp.nso.edu/idl/cak.parameters.

  17. Smith theory and geometric Hecke algebras

    E-print Network

    Treumann, David

    2011-01-01

    In 1960 Borel proved a "localization" result relating the rational cohomology of a topological space X to the rational cohomology of the fixed points for a torus action on X. This result and its generalizations have many applications in Lie theory. In 1934, P. Smith proved a similar localization result relating the mod p cohomology of X to the mod p cohomology of the fixed points for a Z/p-action on X. In this paper we study Z/p-localization ("Smith theory") for constructible sheaves and functions. We show that Smith theory on loop groups is related via the geometric Satake correspondence to some special homomorphisms that exist between algebraic groups defined over a field of small characteristic.

  18. STS-110 Crew Interviews: Steve Smith

    NASA Technical Reports Server (NTRS)

    2002-01-01

    STS-110 Mission Specialist Steve Smith is seen during this preflight interview, where he gives a quick overview of the mission before answering questions about his inspiration to become an astronaut and his career path. Smith outlines his role in the mission in general, and specifically during the docking and extravehicular activities (EVAs). He describes the payload (S0 Truss and Mobile Transporter) and the dry run installation of the S0 truss that will take place the day before the EVA for the actual installation. Smith discusses the planned EVAs in detail and outlines what supplies will be left for the resident crew of the International Space Station (ISS). He ends with his thoughts on the most valuable aspect of the ISS.

  19. SMITH FARM FROM COOK ROAD, LOOKING WEST. (The farm buildings ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    SMITH FARM FROM COOK ROAD, LOOKING WEST. (The farm buildings from left to right are: granary, garage, Gould house, and barn. The Olympic Mountains are visible in the distance.) - Smith Farm, 399 Ebey Road, Coupeville, Island County, WA

  20. Ionized gas in the Smith Cloud

    NASA Astrophysics Data System (ADS)

    Hill, A. S.; Haffner, L. M.; Reynolds, R. J.

    2012-09-01

    We present WHAM observations of H?, [N II], and [S II] in the Smith Cloud. A map of H? emission from the cloud shows ionized gas coincident with the brightest H I emission, but nearly-as-bright H? in some regions with faint H I. The ionized mass of the cloud is at least as large as the neutral mass, >106M?. Ionized gas in the core of the Smith Cloud has an electron temperature 6000 K < T < 16 000 K. The observed ratio [N II]/H? = 0.39 ± 0.09 shows that the cloud has a non-primordial nitrogen abundance, 0.1 - 1× solar.

  1. SMITH INVARIANTS AND DUAL GRADED GRAPHS ALEXANDER MILLER

    E-print Network

    Weinberger, Hans

    SMITH INVARIANTS AND DUAL GRADED GRAPHS ALEXANDER MILLER Abstract. The aim of this paper the Smith invariants immediately, as the eigenvalues are completely understood [3, 15]. Furthermore, we. Background 1 1.1. Differential posets 1 1.2. Eigenvalues 3 1.3. Smith invariants 3 2. Conjecture for r

  2. SMITH AND BARGHNONCONSCIOUS EFFECTS OF POWER NONCONSCIOUS EFFECTS OF POWER

    E-print Network

    Bargh, John A.

    SMITH AND BARGHNONCONSCIOUS EFFECTS OF POWER NONCONSCIOUS EFFECTS OF POWER ON BASIC APPROACH AND AVOIDANCE TENDENCIES Pamela K. Smith Radboud University Nijmegen John A. Bargh Yale University According-24 Address for correspondence: Pamela K. Smith, Department of Social Psychology, Behavioural Science

  3. MIXING CENTRE OF A CHANNEL By Ronald Smith1

    E-print Network

    1 HY-23095 MIXING CENTRE OF A CHANNEL By Ronald Smith1 ABSTRACT: For longitudinally uniform., Mathematical Sciences, Loughborough Univ., Loughborough, LE11 TU, UK. e-mail: Ron.Smith@lboro.ac.uk #12 shorelines. Smith (1982) showed that these two criteria define the same point, which will be defined herein

  4. J. E. SMITH1, 2 , L. KORSTEN1

    E-print Network

    230 J. E. SMITH1, 2 , L. KORSTEN1 AND T. A. S. AVELING2 " Department of Microbiology and Plant of a new anthracnose disease of cowpea (Vigna unguiculata (L.) Walp.) in South Africa (Smith & Aveling. Sunken, necrotic lesions and small black acervuli are visible on the stems (Smith & Aveling, 1997). Three

  5. Adam Smith, Behavioral Economist Nava Ashraf, Colin F. Camerer and

    E-print Network

    Greer, Julia R.

    Adam Smith, Behavioral Economist Nava Ashraf, Colin F. Camerer and George Loewenstein I n The Wealth of Nations, published in 1776, Adam Smith famously argued that economic behavior was motivated by self-interest. But 17 years earlier in 1759, Smith had proposed a theory of human behavior that looks

  6. Smith & Telang/Competing with Free RESEARCH ARTICLE

    E-print Network

    Sadeh, Norman M.

    Smith & Telang/Competing with Free RESEARCH ARTICLE COMPETING WITH FREE: THE IMPACT OF MOVIE BROADCASTS ON DVD SALES AND INTERNET PIRACY 1 By: Michael D. Smith H. John Heinz III School of Public Policy. 321-338/June 2009 321 #12;Smith & Telang/Competing with Free Introduction "We can't compete with free

  7. 10/24/11, Page 1 VITA -Doug Smith

    E-print Network

    Yang, Zong-Liang

    10/24/11, Page 1 VITA - Doug Smith Education: B.S., Geology, 1962, California Institute in Peer-reviewed Journals Smith, D., 2010, Antigorite Peridotite, Metaserpentinite, and other Inclusions-angle Subduction. Journal of Petrology 51, 1355-1379. doi: 10.1093/petrology/egq022 Smith, D., and Griffin, W. L

  8. SMITH NORMAL FORM OF A MULTIVARIATE MATRIX ASSOCIATED WITH PARTITIONS

    E-print Network

    SMITH NORMAL FORM OF A MULTIVARIATE MATRIX ASSOCIATED WITH PARTITIONS CHRISTINE BESSENRODT polynomials, and by determining not only the deter- minant but also the Smith normal form of these matrices. A priori the Smith form need not exist but its existence follows from the explicit computation

  9. THE SMITH COLLEGE DIPLOMA PROBLEM Ira M. Gessel

    E-print Network

    Gessel, Ira M.

    THE SMITH COLLEGE DIPLOMA PROBLEM Ira M. Gessel Department of Mathematics Brandeis University problem, proposed by Russell Maurer, appeared in the American Mathematical Monthly in 1974 [2]: At Smith the Smith College diploma problem, we explain the connection between this interpretation of the Eulerian

  10. Working Papers m 2011:04 Rediscovering Adam Smith

    E-print Network

    Guo, Zaoyang

    Working Papers m 2011:04 Rediscovering Adam Smith HowThe Theory of Moral Sentiments canexplainemergingevidencein experimentaleconomics Douglas E. Stevens #12;AdamSmithResearchFoundation Working Papers Series.AuthorsareadvisedtokeepinmindthegeneralistaudienceoftheWorkingPapersseries andavoidtechnicallanguageandextensivefootnotesasmuchaspossible. m TheAdamSmithResearchFoundation(ASRF)isbasedwithintheCollegeofSocialSciencesat the

  11. SMITH FARM FROM CEMETERY HILL, LOOKING SOUTHWEST. (This image shows ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    SMITH FARM FROM CEMETERY HILL, LOOKING SOUTHWEST. (This image shows the Smith Farm in the center of Ebey?s Prairie. Ebey?s Landing and the Puget Sound can be seen on the right. Farmers from the Sherman-Bishop Dairy are visible at the bottom left, cutting hay.) - Smith Farm, 399 Ebey Road, Coupeville, Island County, WA

  12. Dorothy Blakey Smith Compiled by April Haddad (1980)

    E-print Network

    Handy, Todd C.

    1980-01-01

    Dorothy Blakey Smith fonds Compiled by April Haddad (1980) Last revised October 2012 University (UBC Library catalogue) #12;Fonds Description Dorothy Blakey Smith fonds. ­ 1919-1978. 72 cm of textual records. 78 photographs. Biographical Sketch Born in Leeds, England, Dorothy Blakey Smith immigrated

  13. Rodney K. Smith Award The Rodney K. Smith Award is the highest service award given by the Dean of The University of

    E-print Network

    Dasgupta, Dipankar

    Rodney K. Smith Award The Rodney K. Smith Award is the highest service award given by the Dean of time in one year. Dean Kevin H. Smith explains, "Professor Rodney Smith was a colleague of mine.e., assisting with a visa application or preventing human trafficking). I believe Professor Smith would find

  14. Publications Raymond C Smith Carrillo, C. J., R. C. Smith and D. M. Karl (2004). "Processes regulating

    E-print Network

    California at Santa Barbara, University of

    2004-01-01

    Publications ­ Raymond C Smith Carrillo, C. J., R. C. Smith and D. M. Karl (2004). "Processes regulating oxygen and carbon dioxide in surface waters west of the Antarctic Peninsula." Marine Chemistry 84 and interactions with other climatic change factors." Photochemical and Photobiological Sciences 2: 39-50. Smith, R

  15. 33 CFR 117.841 - Smith Creek.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    33 ? Navigation and Navigable Waters ? 1 ? 2011-07-01 ? 2011-07-01 ? false ? Smith Creek. ? 117.841 ? Section 117.841 ? Navigation and Navigable Waters ? COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ? BRIDGES ? DRAWBRIDGE OPERATION REGULATIONS ? Specific Requirements ? North Carolina ? § 117.841...

  16. 33 CFR 117.841 - Smith Creek.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    33 ? Navigation and Navigable Waters ? 1 ? 2010-07-01 ? 2010-07-01 ? false ? Smith Creek. ? 117.841 ? Section 117.841 ? Navigation and Navigable Waters ? COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ? BRIDGES ? DRAWBRIDGE OPERATION REGULATIONS ? Specific Requirements ? North Carolina ? § 117.841...

  17. 33 CFR 117.841 - Smith Creek.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    33 ? Navigation and Navigable Waters ? 1 ? 2014-07-01 ? 2014-07-01 ? false ? Smith Creek. ? 117.841 ? Section 117.841 ? Navigation and Navigable Waters ? COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ? BRIDGES ? DRAWBRIDGE OPERATION REGULATIONS ? Specific Requirements ? North Carolina ? § 117.841...

  18. 33 CFR 117.841 - Smith Creek.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    33 ? Navigation and Navigable Waters ? 1 ? 2013-07-01 ? 2013-07-01 ? false ? Smith Creek. ? 117.841 ? Section 117.841 ? Navigation and Navigable Waters ? COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ? BRIDGES ? DRAWBRIDGE OPERATION REGULATIONS ? Specific Requirements ? North Carolina ? § 117.841...

  19. 33 CFR 117.841 - Smith Creek.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    33 ? Navigation and Navigable Waters ? 1 ? 2012-07-01 ? 2012-07-01 ? false ? Smith Creek. ? 117.841 ? Section 117.841 ? Navigation and Navigable Waters ? COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ? BRIDGES ? DRAWBRIDGE OPERATION REGULATIONS ? Specific Requirements ? North Carolina ? § 117.841...

  20. Immunological Memory is Associative Derek J. Smith

    E-print Network

    Somayaji, Anil

    Immunological Memory is Associative Derek J. Smith Department of Computer Science University of New Laboratory Los Alamos, NM 87545, USA asp@t10.lanl.gov Abstract This paper argues that immunological memory population in the immune system). Keywords: Immunological Memory, Associative Memory, Cross-Reactive Memory

  1. Adam Smith, Religion, and Tuition Tax Credits.

    ERIC Educational Resources Information Center

    Alexander, Kern

    1983-01-01

    Examines tuition tax credit programs in framework of Adam Smith's ideas on the economic impact of established churches. Finds that tuition tax credits would amount to state expenditures to relieve the financial burden of parochial school parents and would allow churches to invest commercially to maintain their charitable functions. (JW)

  2. CURRICULUM VITAE BRIDGET R. SMITH-KONTER

    E-print Network

    Smith-Konter, Bridget

    accumulation and failure on fractures of Europa and Enceladus Postdoctoral Researcher, Scripps Institution ______________________________________________________________________________ DISSERTATION Title: Three-dimensional Deformation and Stress Models: Exploring One-Thousand Years of Earthquake-analytic viscoelastic earthquake modeling as applied to faulting processes on Enceladus and Europa; PI = B. Smith

  3. Predictability Past Predictability Present Leonard A. Smith

    E-print Network

    Stevenson, Paul

    Predictability Past Predictability Present Leonard A. Smith Centre for the Analysis of Time Series it used to be. Tom Petty 1. Introduction Predictability evolves. The relation between our models and reality is one of similarity, not isomorphism, and predictability takes form only within the context

  4. Another Perspective: An Interview with David Smith

    ERIC Educational Resources Information Center

    Bowman, Ruth A.; Johnson, Kelli

    2005-01-01

    To provide another perspective on evaluation within nonformal settings, "New Directions for Evaluation" recently interviewed David Smith, the coordinator of the Professional Learning to Close the Achievement Gap program for the Kansas City, Kansas, Public Schools, who has extensive background in education and educational research. He formerly held…

  5. Dialogues with Marilyn Cochran-Smith

    ERIC Educational Resources Information Center

    Fiorentini, Dario; Crecci, Vanessa Moreira

    2015-01-01

    For more than 30 years, Dr. Marilyn Cochran-Smith has developed and directed research and contributed to publications about education and "practitioner research," especially about teachers' research and learning in inquiry communities. Her primary topics are inquiry communities, teacher research, teacher education for social…

  6. THE BREEDING BIOLOGY OF SMITH'S LONGSPUR

    Microsoft Academic Search

    JOSEPH R. JEIIL. JR

    INCE 1930, when the railroad connecting the Canadian prairies with the port of Churchill, Manitoba, on Hudson Bay, was completed, the Churchill area has been the scene of many ornithological investigations. Despite this, many of the region's most interesting birds have remained virtually unstudied. One of these is Smith's Longspur (Calcarius pictus) . Our present knowledge of this species on

  7. A mechanical version of the Smith Chart

    Microsoft Academic Search

    J E Knowles

    1958-01-01

    A modification of the Smith Chart has been devised for the purpose of computing the transmission characteristics of non-absorbing optical or electrical multi-element filters. The conventional printed chart is replaced by a system of mechanical linkages together with a spiral computing element. The computer is more accurate, faster and less laborious to use than the orthodox chart.

  8. Jason Owen-Smith Associate Professor

    E-print Network

    Edwards, Paul N.

    Cell Research Goes Global." Stem Cell Reviews and Reports Doi: 10.1007/s12015-012-9391-6. 2011 Scott Trajectories in Pluripotent Stem Cell Research." Cell. 145(6): 820-826. 2011 Owen-Smith, Jason. "The, University Re- search Commercialization, Regional Economic Development, Science Policy, Stem Cells, Collabo

  9. The Smith-Lemli-Opitz syndrome

    Microsoft Academic Search

    Richard I Kelley; Raoul C M Hennekam

    2000-01-01

    The Smith-Lemli-Opitz syndrome (SLOS) is one of the archetypical multiple congenital malformation syndromes. The recent discovery of the biochemical cause of SLOS and the subsequent redefinition of SLOS as an inborn error of cholesterol metabolism have led to important new treatment possibilities for affected patients. Moreover, the recent recognition of the important role of cholesterol in vertebrate embryogenesis, especially with

  10. William B. Atwood 2300 Smith Grade

    E-print Network

    California at Santa Cruz, University of

    for the DELCO experiment. 1979 7th SLAC Summer Institute on Particle Physics. I gave the lecture series entitledWilliam B. Atwood 2300 Smith Grade Santa Cruz, CA 95060 Degrees: B.S. (1970) B.S. in Physics (with

  11. Julian Smith: scientific surgeon, photographer, inventor.

    PubMed

    Vellar, Ivo D

    2002-01-01

    Julian Augustus Romaine Smith was one of the surgeons who, in the company of Thomas Dunhill, Hugh Devine, Douglas Shields and David Murray Morton, established Saint Vincent's Hospital, Melbourne, as arguably the premier surgical hospital in Victoria, if not Australia. Smith abandoned a most promising scientific career to study medicine, completing his medical course in Melbourne where he graduated top of his year in 1898/1899. He gained his MD in 1901 and set up practice in Morwell, a Victorian country town, where he initiated his surgical career. In 1905 Smith returned to Melbourne and worked as assistant to Mr F. D. Bird, a prominent surgeon. He travelled overseas in 1906, visiting leading medical centres in England where Almroth Wright's work on vaccination made a deep impression on him. On his return to Australia in 1908 he joined the surgical staff at Saint Vincent's Hospital as surgeon to outpatients, finally retiring as surgeon to inpatients in 1928. Smith was made a Foundation Fellow of the Australasian College of Surgeons in 1927. Smith was regarded by his peers as a brilliant innovative surgeon with a special interest in urology. He became an expert cystoscopist. After he retired, he continued his long-standing interest in portrait photography for which he was considered a master. During World War II he designed and built an elegant roller pump for use in direct blood transfusion. He died in 1947, survived by his wife, a daughter and three sons, one of whom became President of the Royal Australasian College of Surgeons. PMID:11906425

  12. Development of a commercial Automated Laser Gas Interface (ALGI) for AMS

    NASA Astrophysics Data System (ADS)

    Daniel, R.; Mores, M.; Kitchen, R.; Sundquist, M.; Hauser, T.; Stodola, M.; Tannenbaum, S.; Skipper, P.; Liberman, R.; Young, G.; Corless, S.; Tucker, M.

    2013-01-01

    National Electrostatics Corporation (NEC), Massachusetts Institute of Technology (MIT), and GlaxoSmithKline (GSK) collectively have been developing an interface to introduce CO2 produced by the laser combustion of liquid chromatograph eluate deposited on a CuO substrate directly into the ion source of an AMS system, thereby bypassing the customary graphitization process. The Automated Laser Gas Interface (ALGI) converts dried liquid samples to CO2 gas quickly and efficiently, allowing 96 samples to be measured in as little as 16 h. 14C:12C ratios stabilize typically within 2 min of analysis time per sample. Presented is the recent progress of NEC’s ALGI, a stand-alone accessory to an NEC gas-enabled multi-cathode source of negative ions by Cs sputtering (MC-SNICS) ion source.

  13. Comparative studies of the in vitro dissolution and in vivo pharmacokinetics for different formulation strategies (solid dispersion, micronization, and nanocrystals) for poorly water-soluble drugs: A case study for lacidipine.

    PubMed

    Fu, Qiang; Li, Bo; Zhang, Dong; Fang, Mingming; Shao, Jingbo; Guo, Mengran; Guo, Zhibin; Li, Mo; Sun, Jin; Zhai, Yinglei

    2015-08-01

    Different formulation strategies have been proposed for poorly water-soluble drugs. The objective of this study is to give an in vitro and in vivo comparison of a solid dispersion, micronization, and nanocrystals, with lacidipine as a model substance. Micronized lacidipine was obtained by jet milling, and nanocrystals were prepared by bead milling. The d50 for the microcrystals (11,200nm) was about 20 times larger than that for nanocrystals (623nm). Both colloidal dispersions maintained a crystalline state after milling. Lacipil(®), lacidipine solid dispersion, was purchased from GlaxoSmithKline. It exhibited a much higher in vitro dissolution profile than both the micronized and nanonized tablets while the micronized and nanonized tablets showed approximately a 1.30- and 2.05-fold increase in AUC0-24h compared with Lacipil(®), respectively. Among the three formulation approaches, Lacipil(®) (solid dispersion) exhibited highest dissolution profile, while nanocrystals produced the greatest increase in oral bioavailability. PMID:26047880

  14. Oxygen distribution in proteins defines functional significance of the genome and proteome of the malaria parasite Plasmodium falciparum 3D7.

    PubMed

    Palanisamy, Balamurugan; Heese, Klaus

    2014-02-01

    Although GlaxoSmithKline is on the way to launch the new vaccine candidate 'RTS, S', the search for suitable antimalarial drugs still remains an exceeding challenge because Plasmodium falciparum-mediated malaria is one of the most lethal diseases in the world. Novel innovative ideas are required to identify new potential molecular targets to be able to fight this lethal parasite efficiently. We used an unconventional bioinformatics approach to analyze the entire genome and proteome of the Pf3D7 strain. Because the oxygen (O-) content is a decisive parameter that determines the function of a protein, we analyzed the entire Pf3D7 proteome based on O-containing amino acid expression. Our data disclose a total of four proteins encoded by chromosome (Chr)-4 and Chr-9 that have an outstanding O-controlled character. The identification of the biological significance of these proteins could eventually lead to new vital drug targets. PMID:24330096

  15. Antagonists at the neurokinin receptors--recent patent literature.

    PubMed

    Giardina, Giuseppe A M; Gagliardi, Stefania; Martinelli, Marisa

    2003-08-01

    This review describes the patent applications and relevant scientific literature published during 2002 in the field of novel neurokinin receptor antagonists, with an emphasis on the medicinal chemistry of recent patent publications. A brief update on the development status of compounds including: the neurokinin-1 receptor antagonists aprepitant (Merck & Co Inc), vofopitant, ezlopitant (Pfizer Inc), R-673 (F Hoffmann-La Roche Ltd); the neurokinin-2 receptor antagonists nepadutant (Menarini Ricerche SpA), saredutant (Sanofi-Synthelabo), SR-144190 (Sanofi-Synthelabo) and UK-290795 (Pfizer Inc); and the neurokinin-3 receptor antagonists osanetant (Sanofi-Synthelabo) and talnetant (GlaxoSmithKline plc) will be given. The review also reports the recent published patent literature in the area of novel therapeutic uses and novel formulations and combinations claimed for neurokinin receptor antagonists. PMID:12917772

  16. Asthma & COPD--IQPC's Second Conference.

    PubMed

    Catley, Matthew C

    2010-09-01

    The International Quality & Productivity Center's (IQPC) Second Asthma & COPD conference, held in Philadelphia, included topics covering new therapeutic developments in the field of asthma and COPD. This conference report highlights selected presentations on mAb treatments for asthma, including targeting IL-5, IL-13, IL-9 and TNFa, CCR3 inhibitors, histamine H4 receptor inhibition, novel mouse models of COPD and inhaled antisense asthma therapies. Investigational drugs discussed include mepolizumab (GlaxoSmithKline plc), benralizumab (BioWa Inc/Kyowa Hakko Kirin Co Ltd/MedImmune LLC), AMG-317 (Amgen Inc/Takeda Bio Development Center Ltd), TPI-ASM-8 (Pharmaxis Ltd) and AIR-645 (Altair Therapeutics Inc). PMID:20799138

  17. OOMMPPAA: a tool to aid directed synthesis by the combined analysis of activity and structural data.

    PubMed

    Bradley, Anthony R; Wall, Ian D; Green, Darren V S; Deane, Charlotte M; Marsden, Brian D

    2014-10-27

    There is an ever increasing resource in terms of both structural information and activity data for many protein targets. In this paper we describe OOMMPPAA, a novel computational tool designed to inform compound design by combining such data. OOMMPPAA uses 3D matched molecular pairs to generate 3D ligand conformations. It then identifies pharmacophoric transformations between pairs of compounds and associates them with their relevant activity changes. OOMMPPAA presents this data in an interactive application providing the user with a visual summary of important interaction regions in the context of the binding site. We present validation of the tool using openly available data for CDK2 and a GlaxoSmithKline data set for a SAM-dependent methyl-transferase. We demonstrate OOMMPPAA's application in optimizing both potency and cell permeability and use OOMMPPAA to highlight nuanced and cross-series SAR. OOMMPPAA is freely available to download at http://oommppaa.sgc.ox.ac.uk/OOMMPPAA/ . PMID:25244105

  18. Casopitant, a neurokinin-1 receptor antagonist with anti-emetic and anti-nausea activities.

    PubMed

    Navari, Rudolph M

    2008-07-01

    Casopitant, an inhibitor of the neurokinin-1 receptor, and its mesylate salt, are being developed by GlaxoSmithKline plc for the potential treatment of chemotherapy-induced nausea and vomiting (CINV), post-operative nausea and vomiting (PONV), as well as for anxiety, depression and insomnia. Phase II trials are ongoing for anxiety, depression and insomnia, and further results are awaited from phase III trials of CINV and PONV. At the time of publication, it was expected that applications to the FDA for regulatory approval for CINV and PONV would be filed in 2008. Casopitant was previously being developed for the treatment of overactive bladder; however, in September 2007, this indication was no longer listed on the company's product pipeline. PMID:18600583

  19. Pooled analysis of safety data from pediatric Phase II RTS,S/AS malaria candidate vaccine trials.

    PubMed

    Vekemans, Johan; Guerra, Yolanda; Lievens, Marc; Benns, Sarah; Lapierre, Didier; Leach, Amanda; Verstraeten, Thomas

    2011-12-01

    Prior to progression to Clinical Development Phase III, GlaxoSmithKline Biologicals performed a pooled analysis of phase two safety data following administration of 8860 doses of RTS,S/AS to 2981 children under 5 years old. RTS,S/AS was associated with increased rates of non-serious URTI, rash and diaper dermatitis graded mild or moderate. There was no significant increased rate of overall or single SAEs. Two episodes of simple febrile seizure were estimated to be related to vaccination. Significant decreased relative risks of death, any SAE, any SAE excluding malaria and pneumonia were observed. The results suggest a favourable risk-benefit balance which is to be confirmed in the ongoing Phase III trials. PMID:22108035

  20. Magnetic Fields in the Smith Cloud

    NASA Astrophysics Data System (ADS)

    Hill, Alex S.; Benjamin, R. A.; Mao, S.; McClure-Griffiths, N. M.; Lockman, F. J.; Gaensler, B. M.

    2013-01-01

    The Smith Cloud is a high velocity cloud (HVC) with a cometary morphology indicating an ongoing interaction with the Galactic interstellar medium. Although it is among the best-studied HVCs and the only large HVC mapped in both H I and Halpha, its origin remains unknown. Most formation scenarios have difficulty explaining its coherence after passage through the Galactic halo, but magnetic fields may help to stabilize HVCs against disruption. We present measurements of Faraday rotation of extragalactic radio sources behind the Smith Cloud derived from the NRAO VLA Sky Survey as well as new Karl G. Jansky Very Large Array observations of Faraday rotation. The data show evidence of Faraday rotation due to the cloud; the Faraday rotation is better correlated with the Halpha emission than with the H I emission.

  1. The Smith-Lemli-Opitz syndrome

    PubMed Central

    Kelley, R.; Hennekam, R.

    2000-01-01

    The Smith-Lemli-Opitz syndrome (SLOS) is one of the archetypical multiple congenital malformation syndromes. The recent discovery of the biochemical cause of SLOS and the subsequent redefinition of SLOS as an inborn error of cholesterol metabolism have led to important new treatment possibilities for affected patients. Moreover, the recent recognition of the important role of cholesterol in vertebrate embryogenesis, especially with regard to the hedgehog embryonic signalling pathway and its effects on the expression of homeobox genes, has provided an explanation for the abnormal morphogenesis in the syndrome. The well known role of cholesterol in the formation of steroid hormones has also provided a possible explanation for the abnormal behavioural characteristics of SLOS.???Keywords: Smith-Lemli-Opitz syndrome; cholesterol metabolism; 7-dehydrocholesterol reductase; clinical history; management PMID:10807690

  2. Efficacy and Safety of Fluticasone Furoate/Vilanterol Compared With Fluticasone Propionate/Salmeterol Combination in Adult and Adolescent Patients With Persistent Asthma

    PubMed Central

    Bleecker, Eugene R.; Lötvall, Jan; O’Byrne, Paul M.; Bateman, Eric D.; Medley, Hilary; Ellsworth, Anna; Jacques, Loretta; Busse, William W.

    2013-01-01

    Background: The combination of fluticasone furoate (FF), a novel inhaled corticosteroid (ICS), and vilanterol (VI), a long-acting ?2 agonist, is under development as a once-daily treatment of asthma and COPD. The aim of this study was to compare the efficacy of FF/VI with fluticasone propionate (FP)/salmeterol (SAL) in patients with persistent asthma uncontrolled on a medium dose of ICS. Methods: In a randomized, double-blind, double-dummy, parallel group study, 806 patients received FF/VI (100/25 ?g, n = 403) once daily in the evening delivered through ELLIPTA (GlaxoSmithKline) dry powder inhaler, or FP/SAL (250/50 ?g, n = 403) bid through DISKUS/ACCUHALER (GlaxoSmithKline). The primary efficacy measure was 0- to 24-h serial weighted mean (wm) FEV1 after 24 weeks of treatment. Results: Improvements from baseline in 0- to 24-h wmFEV1 were observed with both FF/VI (341 mL) and FP/SAL (377 mL); the adjusted mean treatment difference was not statistically significant (?37 mL; 95% CI, ?88 to 15, P = 0.162). There were no differences between 0- to 4-h serial wmFEV1, trough FEV1, and asthma control and quality-of-life questionnaire scores. There was no difference in reported exacerbations between treatments. Both treatments were well tolerated, with no clinically relevant effect on urinary cortisol excretion or vital signs and no treatment-related serious adverse events. Conclusions: The efficacy of once-daily FF/VI was similar to bid FP/SAL in improving lung function in patients with persistent asthma. No safety issues were identified. Trial registry: ClinicalTrials.gov; No.: NCT01147848; URL: www.clinicaltrials.gov PMID:23846316

  3. Immune memory to hepatitis B persists in children aged 7-8 years, who were vaccinated in infancy with 4 doses of hexavalent DTPa-HBV-IPV/Hib (Infanrix™ hexa) vaccine.

    PubMed

    Van Der Meeren, Olivier; Bleckmann, Gerhard; Crasta, Priya D

    2014-01-01

    Protection against hepatitis B disease relies on either protective serum antibodies or on the ability of the immune system to mount an anamnestic response when confronted with the hepatitis B virus (HBV). This open multicenter study (EUDRACT: 2010-022538-10) measured antibodies to HBV surface antigen (anti-HBs) in 7-8-year-old children who had received 4 doses of hexavalent diphtheria-tetanus-acellular pertussis-HBV-inactivated poliovirus-Hemophilus influenzae type b conjugate vaccine (DTPa-HBV-IPV/Hib: Infanrix™ hexa; GlaxoSmithKline Vaccines) in the first 2 years of life through routine vaccine services in Germany. The ability of these children to mount an anamnestic response to a challenge dose of monovalent HBV vaccine (Engerix™ B Kinder; GlaxoSmithKline Vaccines) was also assessed. Before the challenge dose, 78.5% of children had anti-HBs levels ?6.2 mIU/mL (seropositive) and 72.2% had anti-HBs levels ?10 mIU/mL (seroprotected). Post-challenge, 98.9% had anti-HBs levels ?10 mIU/mL and 95.8% had anti-HBs ?100 mIU/mL. An anamnestic response to the challenge was observed in 96.6% of all subjects. The challenge dose was well tolerated, with a reactogenicity and safety profile consistent with published data. DTPa-HBV-IPV/Hib induces long-lasting immune memory to HBV that appears very similar to that induced by monovalent HBV vaccines. Protection against hepatitis B may be conferred through immune memory in subjects who responded to primary vaccination, even when they subsequently lose detectable levels of circulating anti-HBs antibodies. PMID:24637296

  4. Deagglomeration of dry powder pharmaceutical aerosols.

    PubMed

    Voss, Austin; Finlay, Warren H

    2002-11-01

    The effect of turbulence and mechanical impaction on dry powder aerosol deaggregation was tested using a novel powder deagglomeration rig, with fine particle fraction (FPF(ED<5.6 microm)), defined here as particles sized smaller than 5.6 microm, measured using an Anderson inertial impactor. Powder from GlaxoSmithKline Ventodisks was deaggregated either using turbulence generated with a ring of impinging jets, or by impacting the powder on bars of a wire mesh. This deaggregation was compared with deaggregation achieved with the GlaxoSmithKline Diskhaler. The turbulence levels in the test rig and at the exit of the Diskhaler were quantified using laser Doppler velocimetry (LDV). In addition, the Ventodisk powder's auto-adhesion properties were altered by introducing the powder into a high humidity environment (25 degrees C and 25% R.H.) and then deagglomerated by both the rig (using turbulence as the primary deagglomeration mechanism) and the Diskhaler. Fine particle fractions were found to increase from 13 to 24% as the level of turbulence in the rig was increased. However, fine particle fractions found with the Diskhaler were 35%. Turbulence levels found in the rig at the highest jet flow rate were significantly higher than that at the outlet of the Diskhaler, leading to the conclusion that turbulence is not the only method of deaggregation in this inhaler. The humidified powders were significantly more difficult to deaggregate, giving a FPF(ED<5.6 microm) of 9% when using the rig and 15% when using the Diskhaler. Fine particle fractions produced when deagglomerating the powder with the wire meshes were similar to those produced without a mesh, showing that mechanical impaction had little effect. The results underline the utility of having a rig that can explore the ability of a powder to deagglomerate with controlled variations in the deaggregation forces. PMID:12429458

  5. Non-clinical safety evaluation of single and repeated intramuscular administrations of MAGE-A3 Cancer Immunotherapeutic in rabbits and cynomolgus monkeys.

    PubMed

    Destexhe, Eric; Grosdidier, Emilie; Baudson, Nathalie; Forster, Roy; Gerard, Catherine; Garçon, Nathalie; Segal, Lawrence

    2015-07-01

    The MAGE-A3 recombinant protein combined with AS15 immunostimulant (MAGE-A3 Cancer Immunotherapeutic) is under development by GlaxoSmithKline for the treatment of lung cancer and melanoma. We performed non-clinical safety studies evaluating potential local and systemic toxic effects induced by MAGE-A3 Cancer Immunotherapeutic in rabbits (study 1) and cynomolgus monkeys (study 2). Animals were allocated to two groups to receive a single (rabbits) or 25 repeated (every 2?weeks) injections (monkeys) of MAGE-A3 Cancer Immunotherapeutic (treatment groups) or saline (control groups). All rabbits were sacrificed 3 days post-injection and monkeys 3 days following last injection (3/5 per gender per group) or after a 3-month treatment-free period (2/5 per gender per group). Local and systemic reactions and MAGE-A3-specific immune responses (monkeys) were assessed. Macroscopic and microscopic (for rabbits, injection site only) post-mortem examinations were performed on all animals. No systemic toxicity or unscheduled mortalities were recorded. Single (rabbits) and repeated (monkeys; up to four times at the same site) injections were well tolerated. Following five to seven repeated injections, limb circumferences increased up to 26% (5?h post-injection), but returned to normal after 1-8 days. Three days after the last injection, enlargements of iliac, popliteal, axillary and inguinal lymph nodes, and increased incidence or severity of mononuclear inflammatory cell infiltrates was observed in injected muscles of treated monkeys. No treatment-related macroscopic findings were recorded after the treatment-free period. MAGE-A3-specific antibody and T-cell responses were raised in all treated monkeys, confirming test item exposure. Single or repeated intramuscular injections of MAGE-A3 Cancer Immunotherapeutic were well tolerated in rabbits and monkeys. Copyright © 2014 GlaxoSmithKline Vaccines. Journal of Applied Toxicology published by John Wiley & Sons, Ltd. PMID:25219328

  6. Approaches to understanding the searching behavior of CrossFire users.

    PubMed

    Cooke, Frank; Kopelev, Nikolai; Schofield, Helen; Boyce, Geraldine; Dunne, Sean

    2002-01-01

    Due to the high costs of purchasing, supporting and training users of desktop chemical information systems, it is important to understand users' behavior in order that deficiencies in their search efficiency and effectiveness can be identified and addressed. CrossFire generates comprehensive log files that can be examined to determine the nature of search activity. At GSK (GlaxoSmithKline) a Log File Parser, CrossParse, has been developed in Visual Basic that enables analysis by individual user name, groups of users or the whole user population. Log files can be analyzed for occasions when specific structural features are built, specific types of search are done and how the results are manipulated. CrossParse produces output that can be saved and analyzed within Microsoft Excel. It also allows determination of numbers of active concurrent users on the CrossFire system. CrossParse has been used at GSK (ex-SmithKline Beecham sites) to examine the search behavior of medicinal and synthetic chemists. Additionally, it has been used by MIMAS (Manchester Information and Associated Services) to compare the search behavior of trained and untrained users in the higher education community and to identify any areas where improvements to training can be made. Use of CrossParse in both organizations has allowed identification of areas where users may have difficulties using CrossFire. This will provide valuable feedback to MDL Inc., the authors of the CrossFire application, and guide them in enhancing CrossFire. PMID:12376989

  7. Smith-Purcell free-electron laser

    SciTech Connect

    Woods, K.J.; Walsh, J.E. [Dartmount College, Hanover, NH (United States)

    1995-12-31

    The term Smith-Purcell free electron laser can be employed generally to describe any coherent radiation source in which a diffraction grating is used to couple an electron beam with the electromagnetic field. To date, most practical developments of this concept have focused on devices which operate in the millimeter spectral regime. In this paper construction of a Smith-Purcell free-electron laser operating in the far-infrared (FIR) region using a novel resonator cavity design and the electron beam from a low energy (0.5-5 MeV) radio-frequency accelerator will be discussed. A tunable source in this region would have many applications and since the beam energy is low, the small size and low overall cost of such a device would make it a laboratory instrument. Current projects which are progressing towards developing a FIR source are the programs at Stanford and CREOL. Both of these projects are using permanent magnet undulators to couple the electron beam with the electromagnetic field. An alternative approach is to use an electron beam passing over a diffraction grating as the radiating mechanism. This phenomenon is known as Smith-Purcell radiation and was first demonstrated for incoherent emission at visible wavelengths. The addition of feedback enhances the stimulated component of the emission which leads to the growth of coherence. Recent calculations for spontaneous emission have shown that the wiggler parameter and the grating efficiency are analogous. This result has important implications for the development of a Smith-Purcell FEL because a grating based free-electron laser would offer a greater range of tunability at a lower cost than its wiggler based counterpart.

  8. Improved Chen-Smith image coder

    Microsoft Academic Search

    Eduardo M. Rubino; Henrique S. Malvar; Ricardo L. de Queiroz

    1993-01-01

    An image compression system based on transform coding and zonal sampling is presented. It is based on the Chen-Smith coder, but with an improved technique for transform coefficient quantization and the replacement of the discrete cosine transform (DCT) by the lapped orthogonal transform (LOT). The system leads to signal-to-noise ratios that are from 1.5 to 2.0 dB above those obtained

  9. Improved Chen-Smith image coder

    Microsoft Academic Search

    Eduardo M. Rubino; Henrique S. Malvar; Ricardo L. De Queiroz

    1993-01-01

    An image compression system based on transform coding and zonal sampling is presented. It is based on the well- known Chen-Smith coder, but with an improved tech- nique for transform coefficient quantization and the re- placement of the discrete cosine transform (DCT) by the lapped orthogonal transform (LOT). The system leads to signal-to-noise ratios that are from 1.5 to 2.0

  10. The Smith Cloud: Galactic or Extragalactic?

    NASA Astrophysics Data System (ADS)

    Fox, Andrew

    2014-10-01

    The Milky Way is surrounded by a population of gaseous high-velocity clouds (HVCs), which play an important role in bringing fresh fuel for star formation into the disk. The Smith Cloud is an HVC in an advanced state of accretion, only ~30 Myr away from impacting the Galactic plane. It is unique among HVCs in having a known distance (12.4 kpc) and a well-constrained 3D velocity (300 km/s), but we do not yet know its metallicity, which would distinguish between Galactic (metal-enriched) and extragalactic (metal-poor) origins. Here we propose a program to measure the Smith Cloud's metallicity using HST/COS spectra of three AGN lying behind the Cloud and its wake. Combining the UV metal-line (O I and S II) column densities with existing H I column densities will lead to precise abundance measurements for the Smith Cloud, directly constraining its origin. In addition, the relative strength of depleted (Fe II, Si II) to undepleted (S II) UV absorption lines will be used to infer its dust content. Finally, we will search for variation in the ionization level and kinematics between the three sight lines, which would indicate a disruptive encounter with the hot Galactic corona.

  11. Comments on Smith Barney's uranium enrichment analysis

    SciTech Connect

    Rezendes, V.S.

    1990-07-01

    In a May 1990 report, Smith Barney, Harris Upham and Co. concluded that DOE's uranium enrichment program should be restructured as a government corporation; all past costs have been recovered, and DOE's customers have been overcharged about $1.2 billion; the government should retain responsibility for environment and decommissioning costs associated with enriched uranium production before the corporation's formation; and at some future time the corporation could be sold to the private sector. This report agrees with Smith Barney's recommendation to restructure the enrichment program as a government corporation, but disagrees that DOE's customers have paid for all past costs. According to the author, Smith Barney did not identify the total environmental or decommissioning costs between the government and the corporation. Since these costs are largely undefined, but could amount to billions, Congress should immediately require the program to begin setting aside funds for these costs. DOE estimates that government purchases are responsible for 50 percent of the decommissioning costs; therefore, the government should share these costs by matching the corporation's fund contributions. This requirement should continue until the existing plants have been decommissioned.

  12. The Smith plan, Texas frontier defense in the 1850's

    E-print Network

    Frysinger, Victor Francis

    1975-01-01

    THE SMITH PLAN TEXAS FRONTIER DEFENSE IN THE 1850'S A Thesis by VICTOR FRANCIS FRYSINGER Submitted to the Graduate College of Texas Algal University in partial fulfillment of the requirement for the degree of MASTER OF ARTS May 1975 Major... Subject: History THE SMITH PLAN TEXAS FRONTIER DEFENSE IN THE 1850'S A Thesis VICTOR FRANCIS FRYS INGER Approved as to style and content by: (Chairman of Committee) (Head of Department) / 7. (Member ) (Member) May 1975 ABSTRACT The Smith Plan...

  13. 2. Historic American Buildings Survey, Delos H. Smith, Photographer, 1940 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Historic American Buildings Survey, Delos H. Smith, Photographer, 1940 IN REAR OF PRESIDENT CANNON'S HOUSE. - St. George Tithing Office, Main & Tabernacle Streets, Saint George, Washington County, UT

  14. Rodney K. Smith Award The Rodney K. Smith Award is the highest service award given by the Dean of the University of

    E-print Network

    Memphis, University of

    Rodney K. Smith Award The Rodney K. Smith Award is the highest service award given by the Dean. Humphreys School of Law, Rodney K. Smith's interest in, and respect for, public service was not limited trafficking). Interim Dean William P. Kratzke explains, "I knew Professor Rodney Smith when he was a faculty

  15. michael smith ornlradioactive beams: equipment & techniques p-induced reaction measurements

    E-print Network

    michael smith ornlradioactive beams: equipment & techniques p-induced reaction measurements Silicon dealing with low purity #12;michael smith ornlradioactive beams: equipment & techniques p-induced reaction of impure beams possible! · Nearly background- free yields! #12;michael smith ornlradioactive beams

  16. Trois bicentenaires : Hume, Condillac, Smith. Adam Smith entre le marginalisme et le marxisme

    Microsoft Academic Search

    Gérard R. Pelletier

    1977-01-01

    It is not easy to understand why, and how, orthodox economists who do not believe either in the labor-theory or in the cost-theory of value, continue to favor Adam Smith's Wealth of Nations, but forget such economists as Condillac, whose value theory is nearer to theirs and whose bicentenary we also commemorate.

  17. 60% Review technical specifications, Deaf Smith Site

    SciTech Connect

    Gast, R.A.

    1987-08-01

    The enclosed documentation for the 60% Review Technical Specifications, Deaf Smith Site includes: Solicitation Documents which represent the eventual Federal Acquisition Regulations (FARs) and Department of Energy Acquisition Regulations (DEARs) that will comprise a segment of the contractual documents for bidders attention; Contract Clauses that will become integral parts for the Fixed Price Construction Contracts applicable to the Exploratory Shaft Facility; Special Contract Requirements that will become contract provisions requiring specific contractor attention; Technical Specifications which have been completed for 60% submission, and the current list of 241 Contract Drawings that have been separately forwarded for review and comment.

  18. The Smith chart and quantum mechanics

    SciTech Connect

    Rosner, J.L. (Enrico Fermi Institute and Department of Physics, University of Chicago, Chicago, Illinois 60637 (United States))

    1993-04-01

    The Schroedinger equation and the equation describing the behavior of voltage on a transmission line are both linear second-order equations, which may be solved by convenient matrix methods. By drawing analogies between these two problems, it is shown that a method used for antenna impedance matching based on the Smith chart corresponds in quantum mechanics to a simple conformal transformation of the logarithmic derivative of the wave function. One thereby can arrive at an elementary derivation of the Wentzel--Kramers--Brillouin quantization condition.

  19. Measurements of Smith--Purcell radiation

    SciTech Connect

    Shih, I.; Salisbury, W.; Masters, D.; Chang, D. (Hughes Aircraft Company, Support Systems, P.O. Box 9399, Long Beach, California 90810-0399 (US))

    1990-03-01

    We present experimental results on Smith--Purcell radiation. Our primary interest was in the measurement of radiation angular distribution, output power, and spectral content. The variations of the angular distribution and the output power were shown for different electron-beam voltages and currents. The output power measured with a 3-mA and 120-kV electron beam was {similar to}30 {mu}W/cm{sup 2}-sr. The spectral analysis of the radiation shows excellent agreement between the measurements and the theoretical predictions. Our results were compared with those obtained by Gover et al. (J. Opt. Soc. Am. B 1, 723 (1984)).

  20. Experimental investigations of Smith--Purcell radiation

    SciTech Connect

    Shih, I.; Chang, D.; Drummond, J.; Dubbs, K.; Masters, D.; Prohaska, R.; Salisbury, W. (Hughes Aircraft Company, Support Systems, P.O. Box 9399, Long Beach, California 90810-0399 (US))

    1990-03-01

    We present experimental investigations of Smith--Purcell radiation and Salisbury's model and emphasize the amplification mechanism and efforts to build a resonator operating in the visible wavelength region. The first experiment demonstrated that electrons can be reflected from a rough surface owing to crystal-lattice diffraction. The second experiment showed that the radiation output increases exponentially as the beam thickness increases, indicating a possible occurrence of lasing action; the results were consistent with Salisbury's model. The last experiment yielded inconclusive results; the use of a more stable electron beam and a blazed grating is suggested for future experiments.

  1. Age, plasticity, and equipotentiality: A reply to Smith

    Microsoft Academic Search

    Jack M. Fletcher; Paul Satz

    1983-01-01

    Responds to comments by A. Smith on the present authors' discussion of recovery of function from brain damage. It is argued that current interpretations of the literature on hemispherectomy and childhood aphasia are not consistent with Smith's viewpoints on age, plasticity, and equipotentiality. An evaluation of these concepts and the issues underlying recovery of function must be based on research

  2. Smith-Lemli-Opitz Syndrome: A Case with Annular Pancreas

    PubMed Central

    Demirdöven, Mehmet; Yazgan, Hamza; Korkmaz, Mevlit; Gebe?çe, Arzu; Tonbul, Alparslan

    2014-01-01

    Smith-Lemli-Opitz syndrome is an autosomal recessive disease of cholesterol metabolism. It is a multiple malformation syndrome with typical dysmorphic features such as bitemporal narrowing, ptosis, epicanthus, microcephaly, micrognathia, and cardiovascular, skeletal, urogenital, and gastrointestinal anomalies. This report presents a typical case of Smith-Lemli-Opitz syndrome with annular pancreas which is an unreported gastrointestinal abnormality. PMID:25165593

  3. Oscar F. Smith Middle School: One Extra Degree

    ERIC Educational Resources Information Center

    Principal Leadership, 2012

    2012-01-01

    This article features Oscar F. Smith Middle School, a challenging school in Chesapeake, Virginia. When Principal Linda Scott exclaims, "Oscar F. Smith Middle School is "hot"!" to visitors, she is not referring to the inside temperature of the bustling school of grades 6-8 located in the historic South Norfolk borough of Chesapeake. She is…

  4. 1. VIEW OF THE SMITH NO. 3 SITE AREA TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. VIEW OF THE SMITH NO. 3 SITE AREA TO THE NORTHWEST. THE MINE OFFICE BUILDING IS IN THE FOREGROUND AND THE TIPPLE AND PROCESSING PLANT ARE IN THE BACKGROUND. - Smith Mine, Bear Creek 1.5 miles West of Town of Bear Creek, Red Lodge, Carbon County, MT

  5. College of Agricultural Sciences Calvin & Merle Smith Wheat Research

    E-print Network

    Grünwald, Niklaus J.

    College of Agricultural Sciences Calvin & Merle Smith Wheat Research Endowment Fund Application PURPOSE The Calvin & Merle Smith Wheat Research Endowment Fund supports a student's work on an OSU wheat of Agricultural Sciences and related fields who are working on OSU wheat research projects. Funds may be used

  6. Evolutionary Ecology Research, 2001, 3: 331344 2001 Adam R. Smith

    E-print Network

    O'Donnell, Sean

    Evolutionary Ecology Research, 2001, 3: 331­344 © 2001 Adam R. Smith Correlated evolution of colony defence and social structure: A comparative analysis in eusocial wasps (Hymenoptera: Vespidae) Adam R. Smith,1 * Sean O'Donnell1 and Robert L. Jeanne2 1 Animal Behavior Area, Department of Psychology

  7. EIGENVALUES AND THE SMITH NORMAL FORM Joseph J. Rushanan

    E-print Network

    Rushanan, Joe J.

    , MA 01730 Abstract. Results are shown that compare the Smith Normal Form (SNF) over the integers on the size of the largest element of the SNF when the matrix is diagonalizable with nonzero integer and its Smith Normal Form (SNF) over the integers. Our goals are more general than those results

  8. (Mis)Representing Underachievement: A Rejoinder to Gorard and Smith

    ERIC Educational Resources Information Center

    Connolly, Paul

    2008-01-01

    This article provides a brief rejoinder to Gorard and Smith's reply to an article I published in a previous issue of British Journal of Sociology of Education. In that original article I provided a critical review of their quantitative research on gender and education in the United Kingdom. In their reply to this article, Gorard and Smith seem to…

  9. Father Knows Best: Using Adam Smith to Teach Transactions Costs

    ERIC Educational Resources Information Center

    Dupont, Brandon

    2014-01-01

    Adam Smith's moral philosophy can be used to introduce economics students to the important idea of transactions costs. The author provides a brief background in this article to Smith's moral philosophy and connects it to the costs of transacting in a way that fits easily into the standard principles of microeconomics classroom. By doing…

  10. H.O. SMITH BOTANIC GARDENS Welcome through Childhood's Gate,

    E-print Network

    Boyer, Elizabeth W.

    H.O. SMITH BOTANIC GARDENS Welcome through Childhood's Gate, the children's garden in the H.O Smith Botanic Gardens. This is your garden--a place of transformation, discovery, and learning. Experience generation. In addition to the Arboretum rules, in the children's garden we ask that visitors please

  11. Deborah K. Smith Department of Geology and Geophysics, MS 22

    E-print Network

    Smith, Deborah K.

    deep-towed side scan sonar images, 25o -29o N, J. Volcan. and Geotherm. Res., 67, 233- 262, 1995. Smith. Smith, Fault scarp identification in side scan sonar and bathymetry from the Mid-Atlantic Ridge using 2 and sizes of seafloor volcanoes on Earth and "Pancake" domes on Venus, J. Volcan. and Geotherm. Res., 73, 47

  12. Smith Forms of Palindromic Matrix Polynomials D. Steven Mackey

    E-print Network

    Mehl, Christian

    Smith Forms of Palindromic Matrix Polynomials D. Steven Mackey Niloufer Mackey Christian Mehl coefficients have a kind of reversal symmetry, a structure we call palindromic. Several properties of scalar to establish the Smith form of regular and singular T-palindromic matrix polyno- mials over arbitrary fields

  13. Smith Forms of Palindromic Matrix Polynomials D. Steven Mackey

    E-print Network

    Mackey, Niloufer

    Smith Forms of Palindromic Matrix Polynomials D. Steven Mackey Niloufer Mackey Christian Mehl coefficients have a kind of reversal symmetry, a structure we call palindromic. Several properties of scalar to establish the Smith form of regular and singular T-palindromic matrix polyno- mials, over arbitrary fields

  14. Numerical algorithms for the computation of the Smith normal

    E-print Network

    Seberry, Jennifer

    the Smith normal form (SNF). The above form of the SNF of a matrix was described in the original paper of Smith [23] on this topic. The SNF can be similarly defined on a nonsquare matrix. Several numerical methods have been proposed and developed for the com­ putation of the SNF of a given integral matrix, see

  15. Cross-situational learning: a mathematical Kenny Smith1

    E-print Network

    Vogt, Paul

    Cross-situational learning: a mathematical approach Kenny Smith1 , Andrew D. M. Smith1 , Richard A] In this paper, we present a mathematical model of cross-situational language learning and us, The Netherlands. {kenny,andrew,paulv}@ling.ed.ac.uk; R.A.Blythe@ed.ac.uk Abstract. We present a mathematical model

  16. Psychotherapy outcome: Smith and Glass' conclusions stand up under scrutiny

    Microsoft Academic Search

    Janet T. Landman; Robyn M. Dawes

    1982-01-01

    Selected a sample of the original set of psychotherapy outcome studies analyzed by M. L. Smith and G. V. Glass for reanalysis to address criticisms of the methodological quality of the studies in the original sample. Results uphold the positive conclusions regarding psychotherapeutic efficacy originally drawn by Smith and Glass. (37 ref)

  17. IONIZED GAS IN THE SMITH CLOUD

    SciTech Connect

    Hill, Alex S.; Haffner, L. Matthew; Reynolds, Ronald J., E-mail: hill@astro.wisc.ed, E-mail: haffner@astro.wisc.ed, E-mail: reynolds@astro.wisc.ed [Department of Astronomy, University of Wisconsin-Madison, Madison, WI 53706 (United States)

    2009-10-01

    We present Wisconsin Halpha Mapper observations of ionized gas in the Smith Cloud, a high-velocity cloud which Lockman et al. have recently suggested is interacting with the Galactic disk. Our Halpha map shows the brightest Halpha emission, 0.43 +- 0.04 R, coincident with the brightest H I, while slightly fainter Halpha emission (0.25 +- 0.02 R) is observed in a region with H I intensities <0.1 times as bright as the brightest H I. We derive an ionized mass of approx>3 x 10{sup 6} M {sub sun}, comparable to the H I mass, with the H{sup +} mass spread over a considerably larger area than that of H I. An estimated Galactic extinction correction could adjust these values upward by 40%. Halpha and [S II] line widths toward the region of brightest emission constrain the electron temperature of the gas to be between 8000 K and 23,000 K. A detection of [N II] lambda6583 in the same direction with a line ratio [N II]/Halpha = 0.32 +- 0.05 constrains the metallicity of the cloud: for typical photoionization temperatures of 8000-12,000 K, the nitrogen abundance is 0.15-0.44 times solar. These results lend further support to the claim that the Smith Cloud is new material accreting onto the Galaxy.

  18. The rise of China: Marx's solution or Adam Smith's? On China's rise in Adam Smith in Beijing by Giovanni Arrighi

    Microsoft Academic Search

    Wu Yuanhua

    2011-01-01

    Adam Smith in Beijing offers a subversive analysis of China's rise, an analysis which has provoked a strong reaction in the academic world outside China. Based on Adam Smith's economic principles and world systems analysis, the book comprehensively explores China's reform and opening up and its market economy, as well as the role they have played in China's rise. In

  19. List of Simons Group Co-workers Prof. Wesley D. Smith, Professor SmithW@byui.edu

    E-print Network

    Simons, Jack

    List of Simons Group Co-workers Prof. Wesley D. Smith, Professor SmithW@byui.edu Department of Chemistry, Brigham Young University, Idaho Rexburg, ID 83460-0500 Dr. Tsung-Tai Chen tt7chen@yahoo.com Computer Scientist, Legislative Assistant, New-Age Worker Vancouver, Canada Prof. John W. Kenney III John

  20. Footedness in world soccer: an analysis of France '98 DAVID P. CAREY,* GEOFF SMITH, DANIEL T. SMITH, JOHN W. SHEPHERD,

    E-print Network

    Aberdeen, University of

    Footedness in world soccer: an analysis of France '98 DAVID P. CAREY,* GEOFF SMITH, DANIEL T. SMITH of foot preference and performance, as well as demonstrating the usefulness of soccer for studies of lateral asymmetries. Keywords: asymmetry, footedness, soccer, World Cup. Introduction Homo sapiens

  1. Trinucleotide repeat expansion and DRPLA (Smith`s disease): Molecular characterization of atrophin-1

    SciTech Connect

    Margolis, R.L.; Li, S.H.; Li, X.J.; Ross, C.A. [Johns Hopkins Univ., Balitmore, MD (United States)

    1994-09-01

    Smith`s disease (also known as dentatorubral pallidoluysian atrophy or DRPLA) is a rare, progressive, fatal neuropsychiatric disorder similar to Huntington`s disease (HD). Smith`s disease is characterized by ataxia, choreoathetosis, myoclonic epilepsy, dementia, and genetic anticipation. Neuropathological findings include prominent cell loss in the dentate nucleus of the cerebellum, the globus pallidus, the red nucleus, and the subthalamic nucleus. An expansion of a CAG trinucleotide repeat encoding polyglutamine in a gene originally identified in our laboratory as part of a program to clone candidate genes for disorders with anticipation has recently been found to cause this disorder. We have identified two families that demonstrate the pathological and genetic features (expanded CAG repeat and anticipation) of this disease. Northern analysis indicates that the gene, which we have termed atrophin-1, is widely expressed as a 5 kb mRNA in normal human brain and peripheral tissues. Brain expression is highest in the cerebellum. The developmental expression of the rat homologues of IT-15 (the gene in which a CAG expansion causes HD) and atrophin-1 were compared. Atrophin-1 was most highly expressed in early rat embryo brain (E16), whereas the greatest expression of IT-15 was in the adult rat brain. Cloning and sequencing of the open reading frame from inserts contained in brain cDNA libraries is in progress. In addition to the CAG repeat, the ORF contains an unusual region of alternating acidic and basic amino acids. Further characterization of atrophin-1, and comparison of it to other genes in which trinucleotide repeat expansion leads to neuropsychiatric disorders, should lead to a better understanding of the pathophysiology by which CAG repeat expansion causes human disease.

  2. Smith-Purcell Radiation from Rough Surfaces

    E-print Network

    Gevorkian, Zh S

    2010-01-01

    Radiation of a charged particle moving parallel to a inhomogeneous surface is considered. Within a single formalism periodic and random gratings are examined. For the periodically inhomogeneous surface we derive new expressions for the dispersion relation and the spectral-angular intensity. In particular, for a given observation direction two wavelengths are emitted instead of one wavelength of the standard Smith-Purcell effect. For a rough surface we show that the main contribution to the radiation intensity is given by surface polaritons induced on the interface between two media. These polaritons are multiply scattered on the roughness of surface and convert into real photons. The spectral-angular intensity is calculated and its dependence on different parameters is revealed.

  3. Coherent Transition and Smith Purcell Radiation Experiments

    SciTech Connect

    Marsh, Roark A.; Kesar, Amit S.; Temkin, Richard J. [Plasma Science and Fusion Center, Massachusetts Institute of Technology, 167 Albany Street, Cambridge, Massachusetts 02139 (United States)

    2006-11-27

    We review results from radiation experiments done at MIT on the Haimson Research Corporation (HRC) 17 GHz linear accelerator. Both Smith-Purcell radiation (SPR), and Coherent Transition radiation (CTR) were observed. To understand SPR, an Electric Field Integral Equation (EFIE) method was developed and confirmed with an experiment. Because our linac produces a train of bunches, radiation was only observed at integer multiples of the RF frequency. New measurements made on CTR show excellent agreement with EFIE expectations, on an absolute scale, and also provide a bunch length measurement. The possibility for an absolute scale bunch length measurement is confirmed with a proof of principle experiment. Future extension of the EFIE code and corollary experiments are discussed.

  4. Sophia Smith Collection: Voices of Feminism

    NSDL National Science Digital Library

    Based at Smith College, the Voices of Feminism Oral History Project "documents the persistence and diversity of organizing for women in the United States in the latter half of the 20th century." The women interviewed here include labor, peace, and anti-racism activists, along with anti-poverty organizers and lesbian rights advocates. The project was funded by the Ford Foundation from 2002 to 2008, and visitors will find that they can also read transcripts of the interviews as well. The "Narrators" page features biographical profiles of each interviewee, along with links to the transcript of each interview. As a bonus feature, there are video excerpts for six of the women interviewed as part of the project.

  5. Laurie Brban and Andr Lapidus Adam Smith on Lotteries 01.12.2013 13:42

    E-print Network

    Paris-Sud XI, Université de

    Laurie Bréban and André Lapidus ­ Adam Smith on Lotteries 01.12.2013 13:42 1 ADAM SMITH The few pages that Adam Smith devoted to lotteries, mainly in the Wealth of Nations (1776) did not receive transformed into risk-aversion. Keywords: Adam Smith, decision, risk, lotteries, stochastic dominance, rank

  6. The Compositional Evolution of the Murid Genome Nick G.C. Smith,1

    E-print Network

    Eyre-Walker, Adam

    The Compositional Evolution of the Murid Genome Nick G.C. Smith,1 Adam Eyre-Walker2 1 Department-Walker 1999; Smith and Eyre- Walker 2001). Given that the GC content of protein- coding genes is highly polymorphism data fromCorrespondence to: Nick Smith; email: nick.smith@ebc.uu.se J Mol Evol (2002) 55

  7. A review of "Andrew Marvell: The Chameleon" by Nigel Smith 

    E-print Network

    Garganigo, Alex

    2012-01-01

    Marvell scholars Nicholas von Maltzahn and Nicholas McDowell, Smith has a #15;ne ear for intertextual echoes (or chimes) that aid attempts to pin down the dates and meanings of various Marvell?s poems. Of course, examinations of echoes and in#12;uence... and Cowley were echoing and revising Marvell?s garden poems, available in now lost manuscripts from the 1650s. Smith?s opening chapter identi#15;es the stakes in current Marvell biography and criticism, which form merely the latest episode in his...

  8. David Simpson Receives 2012 Waldo E. Smith Medal: Citation

    NASA Astrophysics Data System (ADS)

    Lerner-Lam, Arthur

    2013-01-01

    David Simpson was awarded the 2012 Waldo E. Smith Medal at the AGU Fall Meeting Honors Ceremony, held on 5 December 2012 in San Francisco, Calif. The medal is for "extraordinary service to geophysics".

  9. VIEW OF HOWLAND HILL ROAD, JEDEDIAH SMITH STATE PARK. CRESCENT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF HOWLAND HILL ROAD, JEDEDIAH SMITH STATE PARK. CRESCENT CITY, DEL NORTE COUNTY, CALIFORNIA. LOOKING E. - Redwood National & State Parks Roads, California coast from Crescent City to Trinidad, Crescent City, Del Norte County, CA

  10. 35. VIEW OF HOWLAND HILL ROAD, JEDEDIAH SMITH STATE PARK. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    35. VIEW OF HOWLAND HILL ROAD, JEDEDIAH SMITH STATE PARK. CRESCENT CITY, DEL NORTE COUNTY, CALIFORNIA. LOOKING E. - Redwood National & State Parks Roads, California coast from Crescent City to Trinidad, Crescent City, Del Norte County, CA

  11. VIEW OF HOWLAND HILL ROAD, JEDEDIAH SMITH STATE PARK. CRESCENT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF HOWLAND HILL ROAD, JEDEDIAH SMITH STATE PARK. CRESCENT CITY, DEL NORTE COUNTY, CALIFORNIA. LOOKING W. - Redwood National & State Parks Roads, California coast from Crescent City to Trinidad, Crescent City, Del Norte County, CA

  12. VIEW OF HOWLAND HILL ROAD, JEDEDIAH SMITH STATE PARK. CRESCENT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF HOWLAND HILL ROAD, JEDEDIAH SMITH STATE PARK. CRESCENT CITY, DEL NORTH COUNTY, CALIFORNIA. LOOKING ESE. - Redwood National & State Parks Roads, California coast from Crescent City to Trinidad, Crescent City, Del Norte County, CA

  13. MORTALITY ESTIMATES FROM SIZE DISTRIBUTIONS: A CRITIQUE OF SMITH'S MODEL

    EPA Science Inventory

    Smith (1972) described a method of computing mortality rates from growth and size-frequency data for a population which meets several assumptions. (Copyright (c) 1977 by The American Society of Limnology and Oceanography, Inc.)...

  14. 20. Photocopy of photograph (From Frances Rand Smith Collection, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    20. Photocopy of photograph (From Frances Rand Smith Collection, California Historical Society) Photographer unknown, Date unknown VIEW OF CHURCH FROM REAR - Mission San Miguel Arcangel, Highway 101, San Miguel, San Luis Obispo County, CA

  15. 16. Photocopy of photograph (from Frances Rand Smith Collection, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    16. Photocopy of photograph (from Frances Rand Smith Collection, California Historical Society, 1900) Photographer unknown, Date unknown FRONT VIEW OF MISSION, c. 1900 - Mission San Miguel Arcangel, Highway 101, San Miguel, San Luis Obispo County, CA

  16. DETAIL OF WESTINGHOUSE AND B. MORGAN SMITH NAMEPLATES ON ELECTRIC ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    DETAIL OF WESTINGHOUSE AND B. MORGAN SMITH NAMEPLATES ON ELECTRIC GENERATOR IN UPPER LEVEL OF HYDROELECTRIC POWER HOUSE - St. Lucie Canal, Lock No. 1, Hydroelectric Power House, St. Lucie, Cross State Canal, Okeechobee Intracoastal Waterway, Stuart, Martin County, FL

  17. Longitudinal profile monitors using Coherent Smith-Purcell radiation

    NASA Astrophysics Data System (ADS)

    Andrews, H. L.; Bakkali Taheri, F.; Barros, J.; Bartolini, R.; Cassinari, L.; Clarke, C.; Le Corre, S.; Delerue, N.; Doucas, G.; Fuster-Martinez, N.; Konoplev, I.; Labat, M.; Perry, C.; Reichold, A.; Stevenson, S.; Vieille Grosjean, M.

    2014-03-01

    Coherent Smith-Purcell radiation has the potential of providing information on the longitudinal profile of an electron bunch. The E-203 experiment at the FACET User Facility measures bunch profiles from the SLAC linac in the hundreds of femtoseconds range and the SPESO collaboration at Synchrotron SOLEIL is planning to make an accurate 2D map of the Coherent Smith-Purcell Radiation emission.

  18. Kiki Smith: Prints, Books & Things at MoMA

    NSDL National Science Digital Library

    Using a similar interface to that of Artists of Brücke (German Expressionist prints, reviewed in the December 5, 2003 and Nov.2, 2001 Scout Reports), the Museum of Modern Art (MoMA) presents this major retrospective of the work of Kiki Smith, born in 1954 in Nuremberg, Germany. Smith is the daughter of American sculptor Tony Smith, and her first experience with art was helping her father make cardboard models for his geometric sculptures. She is thought of as a sculptor and builder of installations, but since the 1980s, has created an extensive body of printed works, 135 of which are gathered in this web exhibition. Like the Expressionist show, the Smith show features a virtual light table of images that can be arranged dynamically by Themes -- early screen prints, anatomy, self-portraits, nature, feminine contexts -- or Mediums. In recent years, Smith has worked on etchings pulled from plates of monumental size, roughly 4 feet by 6 feet, such as a series based on Lewis Carroll, including Pool of Tears 2 (2000) and Come Away from Her (2003). The site also includes a chronology of Smith's life and a 35-page essay by Wendy Weitman, MoMA's Curator of Prints and illustrated Books.

  19. SMITH NORMAL FORMS OF INCIDENCE MATRICES Abstract. A brief introduction is given to the topic of Smith normal forms of incidence

    E-print Network

    Sin, Peter

    SMITH NORMAL FORMS OF INCIDENCE MATRICES PETER SIN Abstract. A brief introduction is given to the topic of Smith normal forms of incidence matrices. A general discussion of techniques is illustrated, the fundamental invariant is the Smith normal form of A, whose definition we now recall. A square integer matrix

  20. Smith-Purcell free-electron laser

    SciTech Connect

    Schachter, L.; Ron, A.

    1989-07-15

    We analyze the operation of a free-electron laser in an open periodicstructure. When operated as an amplifier, it is shown that exponential gain candevelop in such a device. An analytic expression for this gain is presented,and it is shown that this gain decays exponentially with the beam height abovethe grating; the gain dependence on the beam thickness is also analyzed. As theenergy extraction rate is much higher in an exponential gain regime, we alsoinvestigate the operation of an oscillator based on the same concept. In thiscase, the Smith-Purcell radiation ''provides the startup'' through a feedbacksystem. The latter consists of several mirrors, which are placed in such a waythat (1) only a wave with the desired frequency develops and, at the same time,(2) small deviations in the wave parameters due to the wave-beam interaction donot cause deflection of the wave from the feedback loop. The minimal currentneeded to sustain oscillations is given in an analytical form. Numericalcalculations show that this current is more than three orders of magnitudelower than that necessary for an oscillator which operates in an algebraic gainregime.

  1. Dermatologic features of smith-magenis syndrome.

    PubMed

    Guérin-Moreau, Morgane; Colin, Estelle; Nguyen, Sylvie; Andrieux, Joris; de Leersnyder, Hélène; Bonneau, Dominique; Martin, Ludovic

    2015-05-01

    Smith-Magenis syndrome (SMS) is characterized by distinctive facial and skeletal features, developmental delay, cognitive impairment, and behavioral abnormalities, including self-injurious behaviors. We aimed to investigate whether cutaneous features are common in SMS. We performed a complete skin examination in 20 young SMS patients. Skin features secondary to self-injurious behavior, such as bites, abrasions, dystrophic scars, limited spots of hyperkeratosis, anomalies of the nails, and whitlows, were found in the majority of patients. Acral pachydermia and fissured plantar keratoderma were common. Xerosis was constant and associated with extensive keratosis pilaris in the majority of patients. Dermatofibromas were frequent in older patients. The hair was dense and shiny, with an unusual hairline. Eyelash trichomegaly and heavy brows were common, as well as folliculitis on the back. The skin features of SMS have rarely been reported in the literature. Some of these are the consequence of neurobehavioral features, but some cutaneous features and abnormalities of appendages have not been reported in other related syndromes. Skin manifestations of SMS are varied, sometimes induced by self-injurious behavior and sometimes more specific. It remains to be determined whether the combination of the two kinds of signs could contribute to early diagnosis of the syndrome. PMID:25684097

  2. MAGNETIZED GAS IN THE SMITH HIGH VELOCITY CLOUD

    SciTech Connect

    Hill, Alex S.; McClure-Griffiths, Naomi M. [CSIRO Astronomy and Space Science, Marsfield, NSW (Australia); Mao, S. A. [Department of Astronomy, University of Wisconsin-Madison, Madison, WI (United States); Benjamin, Robert A. [Department of Physics, University of Wisconsin-Whitewater, Whitewater, WI (United States); Lockman, Felix J., E-mail: alex.hill@csiro.au, E-mail: naomi.mcclure-griffiths@csiro.au, E-mail: mao@astro.wisc.edu, E-mail: benjamir@uww.edu, E-mail: jlockman@nrao.edu [National Radio Astronomy Observatory, Green Bank, WV (United States)

    2013-11-01

    We report the first detection of magnetic fields associated with the Smith High Velocity Cloud. We use a catalog of Faraday rotation measures toward extragalactic radio sources behind the Smith Cloud, new H I observations from the Robert C. Byrd Green Bank Telescope, and a spectroscopic map of H? from the Wisconsin H-Alpha Mapper Northern Sky Survey. There are enhancements in rotation measure (RM) of ?100 rad m{sup –2} which are generally well correlated with decelerated H? emission. We estimate a lower limit on the line-of-sight component of the field of ?8 ?G along a decelerated filament; this is a lower limit due to our assumptions about the geometry. No RM excess is evident in sightlines dominated by H I or H? at the velocity of the Smith Cloud. The smooth H? morphology of the emission at the Smith Cloud velocity suggests photoionization by the Galactic ionizing radiation field as the dominant ionization mechanism, while the filamentary morphology and high (?1 Rayleigh) H? intensity of the lower-velocity magnetized ionized gas suggests an ionization process associated with shocks due to interaction with the Galactic interstellar medium. The presence of the magnetic field may contribute to the survival of high velocity clouds like the Smith Cloud as they move from the Galactic halo to the disk. We expect these data to provide a test for magnetohydrodynamic simulations of infalling gas.

  3. Magnetized Gas in the Smith High Velocity Cloud

    NASA Astrophysics Data System (ADS)

    Hill, Alex S.; Mao, S. A.; Benjamin, Robert A.; Lockman, Felix J.; McClure-Griffiths, Naomi M.

    2013-11-01

    We report the first detection of magnetic fields associated with the Smith High Velocity Cloud. We use a catalog of Faraday rotation measures toward extragalactic radio sources behind the Smith Cloud, new H I observations from the Robert C. Byrd Green Bank Telescope, and a spectroscopic map of H? from the Wisconsin H-Alpha Mapper Northern Sky Survey. There are enhancements in rotation measure (RM) of ?100 rad m-2 which are generally well correlated with decelerated H? emission. We estimate a lower limit on the line-of-sight component of the field of ?8 ?G along a decelerated filament; this is a lower limit due to our assumptions about the geometry. No RM excess is evident in sightlines dominated by H I or H? at the velocity of the Smith Cloud. The smooth H? morphology of the emission at the Smith Cloud velocity suggests photoionization by the Galactic ionizing radiation field as the dominant ionization mechanism, while the filamentary morphology and high (?1 Rayleigh) H? intensity of the lower-velocity magnetized ionized gas suggests an ionization process associated with shocks due to interaction with the Galactic interstellar medium. The presence of the magnetic field may contribute to the survival of high velocity clouds like the Smith Cloud as they move from the Galactic halo to the disk. We expect these data to provide a test for magnetohydrodynamic simulations of infalling gas.

  4. Thermodynamic implications of the Stiller-Smith mechanism

    SciTech Connect

    Lee, K.; Clark, N.; George, A.; Petrucci, V.

    1987-01-01

    The Stiller-Smith mechanism is a new mechanism for the translation of linear motion into rotary motion, and has been considered as an alternative to the conventional slider-crank mechanism in the design of internal combustion engines and piston compressors. Piston motion differs between the two mechanisms, being perfectly sinusoidal for the Stiller-Smith case. Plots of dimensionless volume and volume rate change are presented for one engine cycle. It is argued that the different motion is important when considering rate-based processes such as heat transfer to a cylinder wall and chemical kinetics during combustion. This paper also addresses the fact that a Stiller-Smith engine will be easier to configure for adiabatic operation, with many attendant benefits.

  5. Searching for Star Formation in the Smith Cloud

    NASA Astrophysics Data System (ADS)

    Baker, Ashley; Stark, D.; Kannappan, S.

    2013-01-01

    Recent discoveries of star formation in regions previously thought impossible implies new criteria for where stars can form. The Smith Cloud, a high velocity cloud (HVC) primarily comprised of neutral hydrogen located 12 kpc away in the halo of the Milky Way, meets these criteria by having a large reservoir of gas and the tidal pull of the Milky Way as a mechanism for perturbing the gas. We obtained GALEX NUV magnitudes for stars in the field of the Smith Cloud. These sources were matched with WISE and 2MASS catalogs to obtain infrared magnitudes. We determined the expected colors of young stars in these wavelength bands using synthetic spectral libraries. By comparing the observed UV and IR colors of stars to the expected colors of young stars, while also comparing star positions to existing 21cm data, we aim to isolate possible recent star formation in the Smith Cloud.

  6. Additional corrections to the Gross-Llewellyn Smith sum rule

    SciTech Connect

    Londergan, J. T.; Thomas, A. W. [Department of Physics and Center for Exploration of Energy and Matter, Indiana University, Bloomington, Indiana 47405 (United States); CSSM, School of Chemistry and Physics, University of Adelaide, Adelaide SA 5005 (Australia)

    2010-12-01

    We investigate some QCD corrections that contribute to the Gross-Llewellyn Smith sum rule but have not been included in previous analyses of it. We first review the techniques by which the xF{sub 3} structure function is extracted from combinations of neutrino and antineutrino cross sections. Next we investigate corrections to the Gross-Llewellyn Smith sum rule, with particular attention to contributions arising from strange quark distributions and from charge symmetry violating parton distributions. We find that additional corrections from strange quarks and parton charge symmetry violation are likely to have a small but potentially significant role in decreasing the current discrepancy between the experimental and theoretical estimates of the Gross-Llewellyn Smith sum rule.

  7. L.C. Smith College Of Engineering And Computer Science Laura J. Steinberg, Dean

    E-print Network

    Raina, Ramesh

    L.C. Smith College Of Engineering And Computer Science Laura J. Steinberg, Dean 227 Link Hall lcs world. Syracuse University's L.C. Smith College of Engineering and Computer Science (LCS) offers courses

  8. Glan Morfa Community Woodland Jeanette Mays, Collette Hughes, Peter Smith & Jimmy Walker (MRRA)

    E-print Network

    Glan Morfa Community Woodland Jeanette Mays, Collette Hughes, Peter Smith & Jimmy Walker (MRRA areas may have reduced anti-social behaviour. Excellent interpretation - leaflets, signs and Welsh Assembly Government. #12;Glan Morfa Community Woodland Jeanette Mays, Collette Hughes, Peter Smith

  9. COUNTY REVENUE GENERATION HANDBOOK Smith Lever Act and Fees for Service

    E-print Network

    Collins, Gary S.

    COUNTY REVENUE GENERATION HANDBOOK Smith Lever Act and Fees for Service The current USDA user fees is inconsistent with the statutorypurposes ofthe Smith-Lever Act. Therefore,user fees may not be charged

  10. Electron Bunch Length Diagnostic With Coherent Smith-Purcell Radiation

    SciTech Connect

    Nguyen, D.C.

    1997-05-12

    The authors have designed a new technique for measuring subpicosecond electron bunch lengths using coherent Smith-Purcell radiation. This new diagnostic technique involves passing the electron beam in close proximity of a grating with a period comparable to the electron bunch length. The emitted Smith-Purcell radiation will have a coherent component whose angular position and distribution are directly related to the electron bunch length and longitudinal profile, respectively. This new diagnostic technique is inherently simple, inexpensive and non-intercepting. The authors show that the new technique is also scaleable to femtosecond regime.

  11. Smith, D.C., et al., 2000 ODP Technical Note 28

    E-print Network

    Smith, D.C., et al., 2000 ODP Technical Note 28 METHODS FOR QUANTIFYING POTENTIAL MICROBIAL CONTAMINATION DURING DEEP OCEAN CORING 1,2 David C. Smith,3 Arthur J. Spivack,4 Martin R. Fisk,5 Shelley A that these contamination tests be routinely conducted when coring for microbiological studies. 1Smith, D.C., Spivack, A

  12. Smith, Higgin, and Raines Supplementary Data Site-specific folate conjugation to a cytotoxic protein

    E-print Network

    Raines, Ronald T.

    Smith, Higgin, and Raines Supplementary Data ­S1­ Site-specific folate conjugation to a cytotoxic protein Bryan D. Smith, Joshua J. Higgin, and Ronald T. Raines* Page Contents DNA Synthesis S4 References and Notes S5 1 H NMR Spectrum of Folate Analogue 1 #12;Smith, Higgin

  13. The Smith Normal Form of the Incidence Matrix of Skew Lines in PG(3, q)

    E-print Network

    Sin, Peter

    The Smith Normal Form of the Incidence Matrix of Skew Lines in PG(3, q) Peter Sin, University. In our case D = q4I. #12;Smith normal forms A, L define endomorphisms of the free Z-module on lines. Cokernel of A is called the Smith group and the torsion subgroup of the cokernel of L is known

  14. Smith-Type Methods for Balanced Truncation of Large Sparse Systems

    E-print Network

    Gugercin, Serkan

    Smith-Type Methods for Balanced Truncation of Large Sparse Systems Serkan Gugercin1 and Jing for paralleliza- tion. The Smith method [SMI68], the alternating direction implicit (ADI) iteration method [WAS88a], and the Smith(l) method [PEN00b] are the most popular iterative schemes developed for large sparse Lyapunov

  15. Smith Lever Act Cooperative extension work between the Land-Grant Colleges and the United State

    E-print Network

    Tullos, Desiree

    Smith Lever Act Cooperative extension work between the Land-Grant Colleges and the United State Department of Agriculture is authorized by the Smith-Lever Act. The provisions of the Act, in effect in Oregon Oregon 4-H Program Handbook Smith Lever Act February 1995 The amount paid by the Federal

  16. Smith theory and the functor T William G. Dwyer and Clarence W. Wilkerson

    E-print Network

    Wilkerson, Clarence

    Smith theory and the functor T William G. Dwyer and Clarence W. Wilkerson University of Notre Dame]. In this paper we will use techniques of Smith theory [DW] to calculate the functor T explicitly in certain key here our calculation produces a direct analogue of Smith theory (1.2) for actions of elementary abelian

  17. The Smith Normal Form of a Matrix Associated with Young's Lattice

    E-print Network

    The Smith Normal Form of a Matrix Associated with Young's Lattice Tommy Wuxing Cai and Richard P. Stanley Abstract. We prove a conjecture of Miller and Reiner on the Smith normal form of the operator DU be a commutative ring with 1 and M an m×m matrix over R. We say that M has a Smith normal form (SNF) over R

  18. orignal paper: Beyond natural selection and divine intervention: The Lamarckian implication of Adam Smith's invisible hand

    Microsoft Academic Search

    Elias L. Khalil

    2000-01-01

    Adam Smith's invisible hand metaphor (IH) is examined in light of two different accounts of the origin of traits: Charles Darwin's theory of evolutionary optimization and William Paley's theory of divine intervention. Smith's stand supersedes both accounts. For Smith, intermediating drives, such as the sexual one, neither arise accidentally and favored according to their fitness , la Darwin nor planted

  19. Adam Smith School of Business Management Ltd GUIDE TO INFORMATION AVAILABLE THROUGH OUR PUBLICATION SCHEME

    E-print Network

    Glasgow, University of

    Adam Smith School of Business Management Ltd GUIDE TO INFORMATION AVAILABLE THROUGH OUR PUBLICATION and what it might cost. Adam Smith School of Business Management Ltd is wholly publicly owned Where Adam Smith School of Business Management Ltd holds the copyright in its published information

  20. Corruption des travailleurs et ducation dans les socits commerciales selon Adam Smith1

    E-print Network

    Boyer, Edmond

    1 Corruption des travailleurs et éducation dans les sociétés commerciales selon Adam Smith1 Benoît Walraevens2 Résumé : Cet article vise à démontrer la richesse et l'originalité de l'analyse par Smith des effets déshumanisants de la division du travail. Nous soulignons tout d'abord comment Smith se

  1. Local Reasoning about Mashups Philippa Gardner, Gareth Smith, and Adam Wright

    E-print Network

    Gardner, Philippa

    Local Reasoning about Mashups Philippa Gardner, Gareth Smith, and Adam Wright Imperial College homepage Lorem ipsum dolor sit amet, Updates Testing.. Adam Wright Proving... Gareth Smith updates... Adam Wright Proving... Gareth Smith Twitter twitter.example.com Web Browser Fig. 1. Twitter mashup

  2. A Cabinet of Mathematical Curiosities at Teachers College: David Eugene Smith's Collection

    ERIC Educational Resources Information Center

    Murray, Diane R.

    2012-01-01

    This dissertation is a history of David Eugene Smith's collection of historical books, manuscripts, portraits, and instruments related to mathematics. The study analyzes surviving documents, images, objects, college announcements and catalogs, and secondary sources related to Smith's collection. David Eugene Smith (1860-1944) travelled…

  3. 2010 MSU Horticulture Gardens Glass Art by Craig Mitchell Smith Photos by Art and Marlene Cameron

    E-print Network

    2010 MSU Horticulture Gardens ­ Glass Art by Craig Mitchell Smith Photos by Art and Marlene Cameron #12;2010 MSU Horticulture Gardens ­ Glass Art by Craig Mitchell Smith Photos by Art and Marlene Cameron #12;2010 MSU Horticulture Gardens ­ Glass Art by Craig Mitchell Smith Photos by Art and Marlene

  4. Reading Adam Smith after Darwin: On the evolution of propensities, institutions, and sentiments

    Microsoft Academic Search

    Eric Schliesser

    2011-01-01

    This paper calls attention to Smith's “Considerations Concerning the First Formation of Languages” in order to facilitate understanding Adam Smith from an evolutionary perspective. In particular, such an evolutionary view can be discerned in how Smith saw that generic “natural sentiments” are applied and articulated, in light of local circumstances, into “moral sentiments.” In doing so, the paper calls attention

  5. David E. Smith Receives 2012 Charles A. Whitten Medal: Citation

    NASA Astrophysics Data System (ADS)

    Phillips, Roger J.

    2013-01-01

    David E. Smith was awarded the 2012 Charles A. Whitten Medal at the AGU Fall Meeting Honors Ceremony, held on 5 December 2012 in San Francisco, Calif. The medal is for "outstanding achievement in research on the form and dynamics of the Earth and planets."

  6. Living the art of humanbecoming with the Smith family.

    PubMed

    Doucet, Thomas J

    2015-04-01

    The author presents the humanbecoming family model with family living with dementia. A brief overview of the humanbecoming paradigm is presented followed by a discussion about the humanbecoming family model, true presence, and living the art of humanbecoming. A description of the Smith family living with dementia illustrates living the art of humanbecoming. PMID:25805383

  7. Exponential gain in a Smith--Purcell amplifier

    SciTech Connect

    Schaechter, L.; Ron, A.

    1988-09-05

    We study here the gain of an amplifier based on the Smith--Purcell effect. The grating is characterized by a reflection matrix and the gain, in the exponential region, is calculated as a function of the beam height and thickness.

  8. Metacognition as discrimination: Commentary on Smith et al. (2014)

    PubMed Central

    Basile, Benjamin M.; Hampton, Robert R.

    2015-01-01

    Smith et al. critique recent “low-level” associative process models of nonhuman metacognition. We agree with many aspects of their critique. However, the alternative account they offer may not help specify the mechanisms of metacognition. We propose a middle-ground approach, based on the methods of comparative psychophysics, by which metacognition is treated as a discrimination problem. PMID:24866002

  9. Luxury and Economic Development: David Hume and Adam Smith

    Microsoft Academic Search

    Anthony Brewer

    1998-01-01

    David Hume thought that a taste for luxury was desirable because it promoted economic and political development (it brought down feudalism, among other things). Adam Smith's early works follow a very similar line though, unlike Hume, he saw a taste for luxury as rather contemptible despite its desirable effects. In the Wealth of Nations, however, saving is the key to

  10. A Modular Control System for Remote Subsea Eric Stephen Smith

    E-print Network

    Wood, Stephen L.

    for the degree of Master of Science In Ocean Engineering Melbourne, Florida July, 2003 #12;ii © Copyright 2003 by Eric Stephen Smith Stephen L. Wood, Ph.D., P.E. Assistant Professor Ocean Engineering Principle Advisor Andrew Zborowski, Ph.D. Professor and Program Chair Ocean Engineering Héctor Gutierrez, Ph.D., P

  11. A search for star formation in the Smith Cloud

    NASA Astrophysics Data System (ADS)

    Stark, David V.; Baker, Ashley D.; Kannappan, Sheila J.

    2015-01-01

    Motivated by the idea that a subset of high-velocity clouds (HVCs) trace dark matter substructure in the Local Group, we search for signs of star formation in the Smith Cloud, a nearby ˜2 × 106 M? HVC currently falling into the Milky Way. Using GALEX NUV and WISE/2MASS NIR photometry, we apply a series of colour and apparent magnitude cuts to isolate candidate O and B stars that are plausibly associated with the Smith Cloud. We find an excess of stars along the line of sight to the cloud, but not at a statistically significant level relative to a control region. The number of stars found in projection on the cloud after removing an estimate of the contamination by the Milky Way implies an average star formation rate surface density of 10-4.8±0.3 M? yr-1 kpc-2, assuming the cloud has been forming stars at a constant rate since its first passage through the Milky Way ˜70 Myr ago. This value is consistent with the star formation rate expected based on the average gas density of the cloud. We also discuss how the newly discovered star-forming galaxy Leo P has very similar properties to the Smith Cloud, but its young stellar population would not have been detected at a statistically significant level using our method. Thus, we cannot yet rule out the idea that the Smith Cloud is really a dwarf galaxy.

  12. Improving Developer Participation Rates in Surveys Edward Smith

    E-print Network

    Massachusetts at Amherst, University of

    likely contributed to response bias, meaning that the few developers who do respond to such surveys for survey design suggest that non-responders may bias results [5]. Seven papers at the 2012 InternationalImproving Developer Participation Rates in Surveys Edward Smith Computer Science University

  13. Adam Smith and the Teaching of English Literature.

    ERIC Educational Resources Information Center

    Court, Franklin E.

    1985-01-01

    Adam Smith used selections from English literature in his classroom during the eighteenth century because he believed that vernacular literature could provide a ready context for the teaching of ideological, social, and moral lessons. He believed that higher education should prepare students for the real business of the real world. (RM)

  14. Adam Smith and the Moral Economy of the Classroom System.

    ERIC Educational Resources Information Center

    Hamilton, D.

    1980-01-01

    Traces the development of mass schooling to its origins in 19th-century Glasgow. Its importance as an intellectual and economic center enabled Glasgow to invent a solution to the problem of urban schooling, while the association of scholars like Adam Smith with Glasgow University made Scottish educational theories acceptable around the world. (DB)

  15. NETWORK-BASED INTRUSION DETECTION USING NEURAL RASHEDA SMITH

    E-print Network

    Varela, Carlos

    1 NETWORK-BASED INTRUSION DETECTION USING NEURAL NETWORKS RASHEDA SMITH Department of Computer With the growth of computer networking, electronic commerce, and web services, security of networking systems has hacking poses significant problems to these companies, as distributed attacks can render their cyber

  16. THE DMODULE STRUCTURE OF FSPLIT RINGS K. E. Smith \\Lambda

    E-print Network

    Smith, Karen E.

    characteristic as a (left) module over its ring of differential operators and various well studied propertiesTHE D­MODULE STRUCTURE OF F­SPLIT RINGS K. E. Smith \\Lambda The purpose of this note is to point out an interesting connection between the structure of a commutative, Noetherian ring of prime

  17. Ants (Formicidae): Models for Social Complexity Chris R. Smith,1

    E-print Network

    Tschinkel, Walter R.

    Ants (Formicidae): Models for Social Complexity Chris R. Smith,1 Adam Dolezal, Dorit Eliyahu, C INTRODUCTION The family Formicidae (ants) is composed of more than 12,000 described species that vary greatly in size, morphology, behavior, life history, ecology, and social organization. Ants occur in most

  18. Karen Smith: Language Arts Educator of the Year

    ERIC Educational Resources Information Center

    Hudelson, Sarah

    2009-01-01

    This article honors Karen Smith, who has been given NCTE's Outstanding Educator in the English Language Arts award for 2009. Through the voices of many colleagues and former students, the article celebrates Karen as a teacher, learner, mentor, collaborator, scholar, storyteller, and visionary thinker and doer.

  19. TROPHIC DYNAMICS OF STRIPED BASS IN SMITH MOUNTAIN LAKE, VIRGINIA

    EPA Science Inventory

    We examined the adequacy of the forage base to meet demand of striped bass in Smith Mountain Lake, Virginia. In regards to prey supply, mean alewife biomass from 1993-1998 was 37 kg/ha and mean gizzard shad biomass from 1990-1997 was 112 kg/ha. Mean annual alewife surplus produ...

  20. Functional Food Product Development Jim Smith and Edward Charter

    E-print Network

    Haddadi, Hamed

    Functional Food Product Development Edited by Jim Smith and Edward Charter Prince Edward Island Food Technology Centre Charlottetown, Canada A John Wiley & Sons, Ltd., Publication #12;#12;Functional Food Product Development #12;A John Wiley & Sons, Ltd., Publication Functional Food Science

  1. from "The Celebes" (Sulawesi), Apis nigrocincta Fabr. Smith, 1861. However,

    E-print Network

    Paris-Sud XI, Université de

    from "The Celebes" (Sulawesi), Apis nigrocincta Fabr. Smith, 1861. However, most reports about-nest- ing honey bees inhabit Sulawesi and the sur- rounding islands of Indonesia. Maa (1953) recognized Sulawesi, Indonesia were quantitatively analyzed by gas chromatography- mass spectrometry for several

  2. Theory and Design of Smith-Purcell Semiconductor Terahertz Sources 

    E-print Network

    Smith, Don DeeWayne

    2013-12-06

    difficulties reaching the THz, and no THz device of any type operates on the full range at room temperature. This dissertation proposes a novel semiconductor source which utilizes the transferred-electron (Gunn) effect and the Smith-Purcell effect to operate...

  3. A tutorial on Principal Components Analysis Lindsay I Smith

    E-print Network

    Tino, Peter

    this big set of data, and you want to analyse that set in terms of the relationships between the individualA tutorial on Principal Components Analysis Lindsay I Smith February 26, 2002 #12;Chapter 1 Introduction This tutorial is designed to give the reader an understanding of Principal Components Analysis

  4. Captain John Smith and the Enterprise of Virginia: Update.

    ERIC Educational Resources Information Center

    Schick, James B. M.

    1986-01-01

    This article describes the modern-day equivalent prices of items Captain John Smith required for colonists traveling from England to Virginia in 1624. Includes information on wages and cost of living in 1624 and today in the United States. Concludes that the colonists paid a high price for traveling to the New World. (JDH)

  5. Should NASA Embrace Agile Processes? Jefferey Smith, Tim Menzies

    E-print Network

    Menzies, Tim

    Should NASA Embrace Agile Processes? Jefferey Smith, Tim Menzies Lane Department of Computer@jeffereysmith.com,tim@menzies.com Abstract As a growing number of NASA software projects tend to stray from the conventional waterfall method small number of cases. 1 Introduction A growing trend among NASA software projects is the tendency

  6. Titan's atomic and molecular nitrogen tori H. T. Smith,1

    E-print Network

    Johnson, Robert E.

    Titan's atomic and molecular nitrogen tori H. T. Smith,1 R. E. Johnson,1 and V. I. Shematovich2] Shematovich et al. recently showed plasma induced sputtering in Titan's atmosphere is a source of neutral a toroidal nitrogen cloud roughly centered at Titan's orbital radius but gravitationally bound to Saturn

  7. Modeling Building Thermal Response to HVAC Zoning Virginia Smith

    E-print Network

    Whitehouse, Kamin

    Modeling Building Thermal Response to HVAC Zoning Virginia Smith Department of Computer Science HVAC systems account for 38% of building energy usage. Studies have indicated at least 5-15% waste due to unoccu- pied spaces being conditioned. Our goal is to minimize this waste by retrofitting HVAC systems

  8. an interview with Richard Alba Extraordinary Lives: Patti Smith

    E-print Network

    Dennehy, John

    When racial boundaries fade an interview with Richard Alba Extraordinary Lives: Patti Smith What #12;FEATURES A MORE INTEGRATED AMERICA (FOR SOME) 8 In this interview, Distinguished Professor Richard JACKIE GLASTHAL KERRI LINDEN KC TROMMER BARRY DISMAN Director of Graphic Design DONALD CHERRY Graphic

  9. Right Size, Right Way: Smith College's Successful Voluntary Separation Plan.

    ERIC Educational Resources Information Center

    Lovell, Jonathan B.; Keefe, Janice A.

    1992-01-01

    The program of voluntary separation at Smith College (Massachusetts), implemented as an alternative to forced staff layoffs, is described. The plan included generous separation benefits and counseling services. Related issues are discussed, including tax considerations, eligibility, cost estimation, the plan's timeline, information dissemination,…

  10. FUZZY SPATIAL DATA MINING George Brannon Smith Susan M. Bridges

    E-print Network

    Bridges, Susan M.

    FUZZY SPATIAL DATA MINING George Brannon Smith Susan M. Bridges Department of Computer Science Box@cs.mssstate.edu Abstract A fuzzy spatial data mining technique has been developed to extract relationships describing been tested with hand-generated, synthetic, and sonar imagery. Keywords: data mining, spatial relations

  11. A NEW SET OF THERMAL CONDUCTIVITY MEASUREMENTS Michael Smith1

    E-print Network

    Jamieson, Bruce

    A NEW SET OF THERMAL CONDUCTIVITY MEASUREMENTS Michael Smith1 ,Bruce Jamieson1 2 1 Dept. of Civil, AB, Canada ABSTRACT: A new set of thermal conductivity measurements collected over the course of one for empirical relationships between thermal conductivity and layer density. Further subsetting by moist or dry

  12. L.C. SMITH COLLEGE OF ENGINEERING AND COMPUTER SCIENCE

    E-print Network

    Mohan, Chilukuri K.

    L.C. SMITH COLLEGE OF ENGINEERING AND COMPUTER SCIENCE DEPARTMENT OF CIVIL AND ENVIRONMENTAL IN ENVIRONMENTAL ENGINEERING MASTER OF SCIENCE IN ENVIRONMENTAL ENGINEERING SCIENCE MASTER OF SCIENCE laboratories for graduate instruction and research. They include an environmental unit operations laboratory

  13. Harry Smith — recipient of the 2008 Molecular Ecology Prize

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Harry Smith is a scholar, mentor, internationally renowned researcher, eloquent speaker and author, pioneering journal editor and highly valued colleague who has contributed greatly in multiple ways to plant science and the community. He richly deserves the honour of the Molecular Ecology Prize....

  14. A BESSEL FUNCTION MULTIPLIER Daniel Oberlin and Hart F. Smith

    E-print Network

    Aluffi, Paolo

    A BESSEL FUNCTION MULTIPLIER Daniel Oberlin and Hart F. Smith Abstract. We obtain nearly sharp transform, convolution operator, oscillatory integral, Bessel function. Both authors are partially supported n if 0 Ÿ r Ÿ 3n 4 : (7) #12; A BESSEL FUNCTION MULTIPLIER 3 To begin the proof of (4), let ae

  15. experiment actually sees," Smith says. "When we were

    E-print Network

    Pennycook, Steve

    in science depend on atoms and molecules moving," Smith says. "We want to create movies of molecules student Frank Noe, now at the Free University of Berlin, can then link the two datasets. Supercomputer Newsletter April 2011 "We want to create movies of molecules in motion and check experimentally

  16. Air Effects on Large Droplet Impact Frank T Smith1

    E-print Network

    Purvis, Richard

    Air Effects on Large Droplet Impact Frank T Smith1 and Richard Purvis2 UCL, London WC1E 6BT, UK A study is presented of the interaction(s) between air and water in determining the motion of a large surrounding air motion. I.Nomenclature A = magnitude of shear flow in the air c = ratio U /V D

  17. Vision Aid for Power Wheelchair Users Kyle C. Smith

    E-print Network

    Duerstock, Bradley

    recumbency to crouching, to standing, and to many positions in between 1,2 . Therefore, power wheelchairVision Aid for Power Wheelchair Users Kyle C. Smith Carlos A. C. Kemeny Raymond Cipra School University Sreet, West Lafayette, IN 47907 e-mail: bsd@purdue.edu The sitting posture of power wheelchair (WC

  18. Modeling Ocean-Forced Changes in Smith Glacier

    NASA Astrophysics Data System (ADS)

    Lilien, D.; Joughin, I. R.; Smith, B. E.

    2014-12-01

    Glaciers along the Amundsen Coast are changing rapidly, which has drawn substantial scientific and public attention. Modeling and observation suggest warm-water intrusion and consequent melting as the cause of observed changes, and that unstoppable retreat may have already been triggered in some drainages. While Pine Island and Thwaites Glaciers are losing the most mass and have been the predominant objects study, other systems, particularly Smith, Pope and Kohler Glaciers and the corresponding Dotson and Crosson Shelves, are changing more rapidly relative to their size. Though smaller, these glaciers still have potentially large implications for overall regional dynamics as their beds connect below sea level to surrounding basins. In particular, the long, deep trough of Smith Glacier nearly links to the large eastern tributary of Thwaites, potentially causing rapid changes of Smith to have significant impact on the continuing retreat of Thwaites.We implemented a numerical model in Elmer/Ice, an open-source, full-Stokes, finite-element software package, to investigate the response of the Smith/Pope/Kohler system to different initial conditions. We use various parameterizations of sub-shelf melting with constant magnitude to examine the sensitivity of overall dynamics to melt distribution. Because melt distribution affects lateral buttressing and upstream grounded areas, it is potentially an important control on ice shelf and outlet glacier dynamics. Through comparison to the most recent velocity data, we evaluate the ability of differing melt parameterizations to reproduce the behavior currently seen in Smith/Pope/Kohler glaciers. In addition, we investigate the effect of using different years of velocity data with constant elevation input when initiating model runs. By comparing results over the satellite record to initiation with synchronous observations, we assess the accuracy of the often necessary practice of using differently timestamped datasets.

  19. X-29 Research Pilot Rogers Smith

    NASA Technical Reports Server (NTRS)

    1988-01-01

    Rogers Smith, a NASA research pilot, is seen here at the cockpit of the X-29 forward-swept-wing technology demonstrator at NASA's Ames-Dryden Flight Research Facility (later the Dryden Flight Research Center), Edwards, California, in 1988. The X-29 explored the use of advanced composites in aircraft construction; variable camber wing surfaces; the unique forward-swept-wing and its thin supercritical airfoil; strake flaps; and a computerized fly-by-wire flight control system that overcame the aircraft's instability. Grumman Aircraft Corporation built two X-29s. They were flight tested at Dryden from 1984 to 1992 in a joint NASA, DARPA (Defense Advanced Research Projects Agency) and U.S. Air Force program. Two X-29 aircraft, featuring one of the most unusual designs in aviation history, flew at the Ames-Dryden Flight Research Facility (now the Dryden Flight Research Center, Edwards, California) from 1984 to 1992. The fighter-sized X-29 technology demonstrators explored several concepts and technologies including: the use of advanced composites in aircraft construction; variable-camber wing surfaces; a unique forward- swept wing and its thin supercritical airfoil; strakes; close-coupled canards; and a computerized fly-by-wire flight control system used to maintain control of the otherwise unstable aircraft. Research results showed that the configuration of forward-swept wings, coupled with movable canards, gave pilots excellent control response at angles of attack of up to 45 degrees. During its flight history, the X-29 aircraft flew 422 research missions and a total of 436 missions. Sixty of the research flights were part of the X-29 follow-on 'vortex control' phase. The forward-swept wing of the X-29 resulted in reverse airflow, toward the fuselage rather than away from it, as occurs on the usual aft-swept wing. Consequently, on the forward-swept wing, the ailerons remained unstalled at high angles of attack. This provided better airflow over the ailerons and prevented stalling (loss of lift) at high angles of attack. Introduction of composite materials in the 1970s opened a new field of aircraft construction. It also made possible the construction of the X-29's thin supercritical wing. State-of-the-art composites allowed aeroelastic tailoring which, in turn, allowed the wing some bending but limited twisting and eliminated structural divergence within the flight envelope (i.e. deformation of the wing or the wing breaking off in flight). Additionally, composite materials allowed the wing to be sufficiently rigid for safe flight without adding an unacceptable weight penalty. The X-29 project consisted of two phases plus the follow-on vortex-control phase. Phase 1 demonstrated that the forward sweep of the X-29 wings kept the wing tips unstalled at the moderate angles of attack flown in that phase (a maximum of 21 degrees). Phase I also demonstrated that the aeroelastic tailored wing prevented structural divergence of the wing within the flight envelope, and that the control laws and control-surface effectiveness were adequate to provide artificial stability for an otherwise unstable aircraft. Phase 1 further demonstrated that the X-29 configuration could fly safely and reliably, even in tight turns. During Phase 2 of the project, the X-29, flying at an angle of attack of up to 67 degrees, demonstrated much better control and maneuvering qualities than computational methods and simulation models had predicted . During 120 research flights in this phase, NASA, Air Force, and Grumman project pilots reported the X-29 aircraft had excellent control response to an angle of attack of 45 degrees and still had limited controllability at a 67-degree angle of attack. This controllability at high angles of attack can be attributed to the aircraft's unique forward-swept wing- canard design. The NASA/Air Force-designed high-gain flight control laws also contributed to the good flying qualities. During the Air Force-initiated vortex-control phase, the X-29 successfully demonstrated vortex flow control (VFC). This VFC was more effective t

  20. AMERICAN JOURNAL OF SCIENCE KLINE GEOLOGY LABORATORY

    E-print Network

    Royer, Dana

    for a "double-hump" in CO2 during the Phanerozoic, with high values during the early Paleozoic and Mesozoic, and low values during the late Paleozoic and late Mesozoic-to- Cenozoic. Our analyses also support a distinct atmospheric O2 peak during the late Paleozoic (>30%) followed by low values near the Triassic

  1. SMITH: a LIMS for handling next-generation sequencing workflows

    PubMed Central

    2014-01-01

    Background Life-science laboratories make increasing use of Next Generation Sequencing (NGS) for studying bio-macromolecules and their interactions. Array-based methods for measuring gene expression or protein-DNA interactions are being replaced by RNA-Seq and ChIP-Seq. Sequencing is generally performed by specialized facilities that have to keep track of sequencing requests, trace samples, ensure quality and make data available according to predefined privileges. An integrated tool helps to troubleshoot problems, to maintain a high quality standard, to reduce time and costs. Commercial and non-commercial tools called LIMS (Laboratory Information Management Systems) are available for this purpose. However, they often come at prohibitive cost and/or lack the flexibility and scalability needed to adjust seamlessly to the frequently changing protocols employed. In order to manage the flow of sequencing data produced at the Genomic Unit of the Italian Institute of Technology (IIT), we developed SMITH (Sequencing Machine Information Tracking and Handling). Methods SMITH is a web application with a MySQL server at the backend. Wet-lab scientists of the Centre for Genomic Science and database experts from the Politecnico of Milan in the context of a Genomic Data Model Project developed SMITH. The data base schema stores all the information of an NGS experiment, including the descriptions of all protocols and algorithms used in the process. Notably, an attribute-value table allows associating an unconstrained textual description to each sample and all the data produced afterwards. This method permits the creation of metadata that can be used to search the database for specific files as well as for statistical analyses. Results SMITH runs automatically and limits direct human interaction mainly to administrative tasks. SMITH data-delivery procedures were standardized making it easier for biologists and analysts to navigate the data. Automation also helps saving time. The workflows are available through an API provided by the workflow management system. The parameters and input data are passed to the workflow engine that performs de-multiplexing, quality control, alignments, etc. Conclusions SMITH standardizes, automates, and speeds up sequencing workflows. Annotation of data with key-value pairs facilitates meta-analysis. PMID:25471934

  2. Wayne Smith Leadership Award Application The Wayne Smith Leadership Award was established "To be used at the discretion of the Director of the School

    E-print Network

    Watson, Craig A.

    Wayne Smith Leadership Award Application The Wayne Smith Leadership Award was established "To be used at the discretion of the Director of the School to support leadership of professional projects of student organizations in the School and/or to support student leaders who participate in formal leadership

  3. Defenses and morality: Adam Smith, Sigmund Freud, and contemporary psychoanalysis.

    PubMed

    Gabrinetti, Paul A; Özler, Sule

    2014-10-01

    In this paper we follow the development and transmission of moral learning from Adam Smith's impartial spectator to Sigmund Freud's superego and then to contemporary psychoanalysis. We argue that defenses are an integral component in the acquisition of any moral system. Elaborating on this argument, we assert that there is a progression from defensive systems that are "closed" to defensive systems that are "open," as defined in a recent work by Novick and Novick. The former system is "static, avoids reality, and is characterized by power dynamics, sadomasochism, and omnipotent defense." The latter, on the other hand, is a system that allows for "joy, creativity, spontaneity, love and it is attuned to reality." Furthermore, while Smith and Freud's systems are more one-person systems of defense, contemporary psychoanalysis has moved to more of a two-person system. PMID:25247288

  4. The Stiller-Smith Engine: Floating gear analysis

    SciTech Connect

    Craven, R.; Smith, J.E.; Butler, S.

    1987-01-01

    The Stiller-Smith Engine employs a non-standard gear train and as such requires a closer examination of the design and sizing of the gears. To accomplish this the motion of the Stiller-Smith gear train is compared to more familiar arrangements. The results of a kinematic and dynamic analysis introduce the irregular forces that the gears are subjected to. The ''floating'' or ''trammel'' gear is examined more closely, first stochastically and then with finite element analysis. This pinpoints high stress concentrations on the gear and where they occur during the engine cycle. The configuration considered is an output shaft, negligible idler gear forces, and floating gear pins that are part of the connecting rods rather than the floating gear. Various loading techniques are discussed with possible ramifications of each.

  5. Fenimore Art Museum: The Smith and Telfer Photographic Collection

    NSDL National Science Digital Library

    The Fenimore Art Museum in New York has a wide-ranging collection that includes significant pieces of American Indian art, folk art, and thousands of photographs and negatives. Working together with other institutions, including the New York State Historical Association, they have digitized over 300 images from the Smith and Telfer Photographic Collection. The firm of Smith and Telfer documented the town of Cooperstown, NY for well over a century, and they took photos of circus animals, civic monuments, and prominent individuals. Visitors can browse through the images at their leisure, and they can also search the entire collection by keyword. A couple of images of note include the shot of a man holding a dog in his lap while sitting on a tractor ("Ainslie Cornfield") and the photo entitled "Balloon Ascension".

  6. X-ray generation by the Smith-Purcell effect

    SciTech Connect

    Moran, M.J. (Lawrence Livermore National Laboratory, University of California L-41, P.O. Box 808, Livermore, California 94550 (United States))

    1992-10-26

    Smith-Purcell (S-P) radiation is produced when electrons graze the surface of a grating. Calculations based on the theory of diffraction radiation show that, given severe restrictions on {ital e}{sup {minus}}-beam quality, S-P radiation is highly efficient. Efficient S-P x-ray generation requires relativistic {ital e}{sup {minus}} beams having a transverse momentum and dimension whose product approaches the Heisenberg uncertainty limit.

  7. NORTH FORK SMITH RIVER ROADLESS AREA, CALIFORNIA AND OREGON.

    USGS Publications Warehouse

    Gray, Floyd; Hamilton, Michael

    1984-01-01

    Geologic, geochemical, and geophysical investigations and a survey of mines and prospects were conducted to evaluate the mineral-resource potential of the North Fork Smith River Roadless Area, California. The area has probable and sustantiated resource potential for nickel, chromium, copper, and mercury and approximately 2300 mining claims exist in or adjacent to the area. The geologic terrane precludes the occurrence of fossil fuel resources.

  8. Optimization of parameters of Smith-Purcell BWO.

    SciTech Connect

    Kumar, V.; Kim, K.-J.; Accelerator Systems Division (APS); RRCAT

    2006-01-01

    We study the dependence of start current in Smith-Purcell backwardwave oscillator (SP-BWO) on grating parameters and electron beam parameters. The attenuation due to finite conductivity of the grating material is taken into account and three-dimensional effects are included in an approximate way in the analysis. We find that the start current can be significantly reduced by optimizing the grating parameters.

  9. The fine structure of Mastogloia grevillei Wm. Smith

    Microsoft Academic Search

    E. F. Stoermer; H. S. Pankratz; R. W. Drum

    1964-01-01

    Summary 1.An account of the cellular fine structure ofMastogloia grevillei Wm. Smith is presented.2.The chambers of the punctae become flattened as they pass through the wall and open to the cell interior through three smaller pores.3.Voigt's (1955) observation that, during cell division, the new hypotheca is fully formed before the septum is implaced is confirmed.4.The locules contain cytoplasm which is

  10. Metacognition as discrimination: commentary on Smith et al. (2014).

    PubMed

    Basile, Benjamin M; Hampton, Robert R

    2014-05-01

    Smith, Couchman, and Beran (2014, pp. 115-131) critique recent "low-level" associative process models of nonhuman metacognition. We agree with many aspects of their critique. However, the alternative account they offer may not help specify the mechanisms of metacognition. We propose a middle-ground approach, based on the methods of comparative psychophysics, by which metacognition is treated as a discrimination problem. PMID:24866002

  11. Numerical simulation of Smith-Purcell free-electron lasers.

    SciTech Connect

    Kumar, V.; Kim, K.-J.; Accelerator Systems Division (APS)

    2005-01-01

    We present a one-dimensional time-dependent analysis and simulation of Smith-Purcell (SP) free-electron lasers (FELs). The coupled Maxwell-Lorentz equations are set up, and the details of numerical simulation are presented. At low electron beam energy, a SP-FEL is a backward wave oscillator (BWO), and oscillations can be achieved without the need for feedback mirrors. In the linear regime, we show that the optical power grows exponentially if the current is larger than a certain value, the start current. Results of our numerical calculation compare well with the analytic calculation in the linear regime and show saturation behavior in the nonlinear regime. An electron beam traveling close and parallel to a mettalic grating, with grating rulings perpendicular to the electron motion, gives off polarized electromagnetic radiation known as Smith-Purcell radiation. A Smith-Purcell free-electron laser (SP-FEL) based on this effect is interesting as a possible compact source of tunable, coherent THz radiation. Analytic theory of SP-FELs in the linear regime has been discussed by several authors under different approximations. Here, we present a fully self-consistent nonlinear analysis, which can be used to understand the saturation behavior and simulate the realistic effects; coupled Maxwell-Lorentz equations for an SP-FEL driven by sheet beam are derived and solved numerically to perform detailed analysis.

  12. Immunogenicity of HBV vaccine during stated shelf-life.

    PubMed

    Gloriani, Nina G; Srinivasa, Karthik; Bock, Hans L; Hoet, Bernard

    2010-07-01

    Thiomersal has been used as preservative in multi-dose vials of hepatitis B vaccine (Engerix-B). Due to safety concerns, thiomersal was replaced with 2-phenoxyethanol (2PE) as preservative in multi-dose vials. The potency of 2PE preserved hepatitis B vaccine multiple use vials was measured over the shelf-life in terms of immunogenicity, reactogenicity and safety. This single-blind, randomized study was conducted with the assistance of employees of GlaxoSmithKline Biologicals, makers of the Engerix-B vaccine. Four hundred twenty subjects aged > or =18 years were randomized to receive three doses (0, 1, 6 months) of 2PE preserved hepatitis B vaccine kept on the shelf <12 months (2PE New group), 2PE preserved hepatitis B vaccine kept on the shelf >18 months (2PE Old group), or thiomersal preserved hepatitis B vaccine [HBV(Thio) group]. Anti-HBs was measured by GlaxoSmithKline Biologicals post-vaccination; the reactogenicity and safety of the vaccines were assessed. Protective anti-HBs levels (> or =10 mIU/ml) were measured one month after dose 3. The results showed protective levels in 86.8% (2PE New), 89% (2PE Old) and 95.3% [HBV(Thio)]. There was no difference detected between the 2PE New and 2PE Old groups in terms of anti-HBs seroprotection rates and geometric mean concentrations one month after dose 3. However, both 2PE groups had significantly lower seroprotection rates than the HBV(Thio) group and the number of non-responders was higher in the 2PE groups than in the Thio group. A antibody response rates over time were similar between the 2PE New and Old groups. The reactogenicity profiles were acceptable and the ranges were similar for each group. The shelf-life of the vaccines had no impact on immunogenicity or reactogenicity and 2PE preserved hepatitis B vaccine can be considered stable over time. PMID:21073062

  13. Distortion of the Terminal Portion of the QRS on the Admission Electrocardiogram in Acute Myocardial Infarction and Correlation With Infarct Size and Long-Term Prognosis (Thrombolysis In Myocardial Infarction 4 Trial) * * This study was supported in part by a grant from SmithKline Beecham, Philadelphia, Pennsylvania

    Microsoft Academic Search

    Yochai Birnbaum; Robert A. Kloner; Samuel Sclarovsky; Christopher P. Cannon; Carolyn H. McCabe; Vicki G. Davis; Barry L. Zaret; Frans J. Th. Wackers; Eugene Braunwald

    1996-01-01

    Previous studies have shown an association between distortion of the terminal portion of the QRS (QRS[+] pattern: emergence of the J point ?50% of the R wave in leads with qR configuration, or disappearance of the S wave in leads with an Rs configuration) on admission and in-hospital mortality in acute myocardial infarction (AMI). However, the mechanism for this association

  14. Smith-Purcell free electron laser based on a semi-conical resonator

    NASA Astrophysics Data System (ADS)

    Meng (???), Xianzhu

    2012-03-01

    We investigate a Smith-Purcell free electron laser composed of an electron gun, a semi-conical resonator, a metallic grating and collector. The semi-conical resonator could reflect all Smith-Purcell radiation with emission angle ?, and with random azimuthal angles, back onto the electron beam and causes the electrons to be modulated. Tunable coherent far-infrared Smith-Purcell radiation with a high output peak power at millimeter wavelengths can be generated.

  15. 78 FR 23845 - Drawbridge Operation Regulations; Narrow Bay, Smith Point, NY

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-23

    The Commander, First Coast Guard District, has issued a temporary deviation from the regulation governing the operation of the Smith Point Bridge, mile 6.1, across Narrow Bay, between Smith Point and Fire Island, New York. The deviation is necessary to facilitate the Smith Point Triathlon. This deviation allows the bridge to remain closed for two hours to facilitate public safety during a public......

  16. Beyond natural selection and divine intervention: The Lamarckian implication of Adam Smith's invisible hand

    Microsoft Academic Search

    Elias L. Khalil

    2000-01-01

    .   Adam Smith's invisible hand metaphor (IH) is examined in light of two different accounts of the origin of traits: Charles\\u000a Darwin's theory of evolutionary optimization and William Paley's theory of divine intervention. Smith's stand supersedes both\\u000a accounts. For Smith, intermediating drives, such as the sexual one, neither arise accidentally and favored according to their\\u000a fitness à la Darwin nor

  17. Three-dimensional simulation of super-radiant Smith-Purcell radiation

    SciTech Connect

    Li, D.; Imasaki, K.; Yang, Z.; Park, Gun-Sik [Institute for Laser Technology, 2-6 Yamada-oka, Suita, Osaka 565-0871 (Japan); Institute of High-Energy Electronics, University of Electronic Science and Technology of China, Chengdu 610054 (China); School of Physics, Seoul National University, Seoul 151-747 (Korea, Republic of)

    2006-05-15

    A simulation of coherent and super-radiant Smith-Purcell radiation is performed in the gigahertz regime using a three-dimensional particle-in-cell code. The simulation model supposes a rectangular grating to be driven by a single electron bunch and a train of periodic bunches, respectively. The true Smith-Purcell radiation is distinguished from the evanescent wave, which has an angle independent frequency lower than the minimum allowed Smith-Purcell frequency. We also find that the super-radiant radiations excited by periodic bunches are emitted at higher harmonics of the bunching frequency and at the corresponding Smith-Purcell angles.

  18. Analysis of super-radiant Smith-Purcell emission

    SciTech Connect

    Flory, Curt A. [Agilent Laboratories, Palo Alto, California 94304 (United States)

    2006-03-01

    Smith-Purcell emission is studied for a system with no incident field or electromagnetic feedback mechanism other than what is provided by the grating itself. A model is developed that analyzes the interaction between the electron beam and the grating electromagnetic modes. The system of equations is solved numerically, demonstrating linear emitted power versus current at low current levels and super-radiant power emission at higher currents. These results are compared to the previously published experimental data, and the model is used to gain some understanding of the physical mechanisms at work.

  19. Boundaries and interfaces in materials: The David A. Smith symposium

    SciTech Connect

    Pond, R.C. (ed.) (Univ. of Liverpool (United Kingdom). Dept. of Materials Science and Engineering); Clark, W.A.T. (ed.) (Ohio State Univ., Columbus, OH (United States). Dept. of Materials Science and Engineering); King, A.H. (ed.) (State Univ. of New York, Stony Brook, NY (United States). Dept. of Materials Science and Engineering); Williams, D.B. (ed.) (Lehigh Univ., Bethlehem, PA (United States

    1998-01-01

    Just over a year ago David Smith died. Then the loss of a distinguished scientist and dedicated teacher was mourned. Now it is time to celebrate his accomplishments both as a scientist and teacher and this book serves as a reminder of his many contributions to the field of boundaries and interfaces. Researchers from ten countries contributed their work to the symposium, many of whom were former students of David from his years in Oxford. This emphasizes David's tremendous effect on the career of many established scientists through his role as both a teacher and an advisor. Separate abstracts were prepared for 38 papers in this book.

  20. Understanding the output of a Smith-Root GPP electrofisher

    USGS Publications Warehouse

    Miranda, L.E.; Spencer, A.B.

    2005-01-01

    There is confusion among biologists about the use of the percent of range control in the GPP series of Smith-Root electrofishers. We evaluated the output of a GPP 7.5 electrofisher to examine how adjustments to the percent of range control affect voltage, pulse width, duty cycle, and waveform. We found that contrary to how most users interpret the labels on the GPP unit, adjustments to the percent of range control are linked only indirectly to changes in peak voltage. Suggestions for dealing with the restrictions of the GPP units are offered. ?? Copyright by the American Fisheries Society 2005.

  1. Forward directed Smith-Purcell radiation from relativistic electrons

    SciTech Connect

    Woods, K.J.; Walsh, J.E. [Department of Physics and Astronomy, Dartmouth College, Hanover, New Hampshire 03755 (United States)] [Department of Physics and Astronomy, Dartmouth College, Hanover, New Hampshire 03755 (United States); Stoner, R.E. [Massachusetts Institute of Technology and Research Laboratory of Electronics, Cambridge, Massachusetts 02139 (United States)] [Massachusetts Institute of Technology and Research Laboratory of Electronics, Cambridge, Massachusetts 02139 (United States); Kirk, H.G.; Fernow, R.C. [Department of Physics, Brookhaven National Laboratory, Upton, New York 11973 (United States)] [Department of Physics, Brookhaven National Laboratory, Upton, New York 11973 (United States)

    1995-05-08

    The requirements for the generation of forward directed Smith-Purcell emission from relativistic electrons are introduced, and the first experimental evidence of this phenomenon is presented. The experiments were conducted with a 2.8 MeV/{ital c} electron beam interacting with a 1 cm period grating. Radiation emitted in two bands with wavelengths ranging from 600 to 650 {mu}m and 1.2 to 1.7 mm were measured. Grating period to wavelength ratios were as high as 16. The measured intensities are higher than that predicted by incoherent emission.

  2. STS-110 M.S. Smith suits up for TCDT

    NASA Technical Reports Server (NTRS)

    2002-01-01

    KENNEDY SPACE CENTER, FLA. -- STS-110 Mission Specialist Steven Smith relaxes during suit fit, which is part of Terminal Countdown Demonstration Test activities. The TCDT is held at KSC prior to each Space Shuttle flight to provide flight crews an opportunity to participate in simulated launch countdown activities. Scheduled for launch April 4, the 11-day mission will feature Shuttle Atlantis docking with the International Space Station (ISS) and delivering the S0 truss, the centerpiece-segment of the primary truss structure that will eventually extend over 300 feet.

  3. L.C. Smith College Of Engineering And Computer Science Laura J. Ste inbe rg, De an

    E-print Network

    Raina, Ramesh

    L.C. Smith College Of Engineering And Computer Science Laura J. Ste inbe rg, De an 227 Link Hall in a dynamic, rapidly changing world. Syracuse University's L.C. Smith College of Engineering and Computer

  4. 77 FR 442 - Changes To Implement Miscellaneous Post Patent Provisions of the Leahy-Smith America Invents Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-05

    ...Miscellaneous Post Patent Provisions of the Leahy-Smith America Invents Act AGENCY: United States Patent and Trademark Office, Commerce. ACTION: Notice of proposed rulemaking...SUMMARY: The Leahy-Smith America Invents Act expands the...

  5. 77 FR 42149 - Changes To Implement the Preissuance Submissions by Third Parties Provision of the Leahy-Smith...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-17

    ...United States Patent and...Provision of the Leahy-Smith America Invents Act...DEPARTMENT OF COMMERCE United States Patent and...Provision of the Leahy-Smith America Invents Act AGENCY: United States Patent...

  6. 76 FR 60733 - Drawbridge Operation Regulations; Narrow Bay, Smith Point, NY

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-30

    The Commander, First Coast Guard District, has issued a temporary deviation from the regulation governing the operation of the Smith Point Bridge, 6.1, across Narrow Bay, between Smith Point and Fire Island, New York. The deviation is necessary to facilitate bridge rehabilitation. This deviation allows the bridge to open only one of the two moveable spans for the passage of vessel...

  7. 2. VIEW OF THE SMITH NO.3 SITE ARE TO THE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. VIEW OF THE SMITH NO.3 SITE ARE TO THE NORTHEAST. THE BLACKSMITH/MINE CAR REPAIR SHOP IS LEFT CENTER. THE PROCESSING PLANT AND TIPPLE ARE RIGHT CENTER. - Smith Mine, Bear Creek 1.5 miles West of Town of Bear Creek, Red Lodge, Carbon County, MT

  8. Modelling the joint torques and loadings during squatting at the Smith machine

    Microsoft Academic Search

    Andrea Biscarini; Paolo Benvenuti; Fabio Botti; Francesco Mastrandrea; Silvano Zanuso

    2011-01-01

    An analytical biomechanical model was developed to establish the relevant properties of the Smith squat exercise, and the main differences from the free barbell squat. The Smith squat may be largely patterned to modulate the distributions of muscle activities and joint loadings. For a given value of the included knee angle (?knee), bending the trunk forward, moving the feet forward

  9. Fast Parallel Computation of Hermite and Smith Forms of Polynomial Matrices

    Microsoft Academic Search

    Erich Kaltofen; M. S. Krishnamoorthy; B. David Saunders

    1987-01-01

    Boolean circuits of polynomial size and poly-logarithmic depth are given for com- puting the Hermite and Smith normal forms of polynomial matrices over finite fields and the field of rational numbers. The circuits for the Smith normal form computation are probabilis- tic ones and also determine very efficient sequential algorithms. Furthermore, we give a polynomial-time deterministic sequential algorithm for the

  10. Two Rival Conceptions of Vocational Education: Adam Smith and Friedrich List.

    ERIC Educational Resources Information Center

    Winch, Christopher

    1998-01-01

    Examines and discusses two views of political economy: (1) the classical model of Adam Smith; and (2) the social capitalist model associated with Friedrich List. Explores two varieties of vocational education and training that emerge from a comparison of Smith's and List's ideas. (CMK)

  11. Rhetorical Studies: A Reassessment of Adam Smith's Lectures on Rhetoric and Belles Lettres.

    ERIC Educational Resources Information Center

    Purcell, William M.

    1986-01-01

    Offers a dissenting interpretation of Adam Smith's Lectures on Rhetoric and Belles Lettres and a more conservative perspective on Smith's significance to the history of rhetorical theory. Views the lectures as an historical commentary on literature and rhetoric from the perspective of an eighteenth-century lecturer. (JD)

  12. How To Survive in Postindustrial Environments: Adam Smith's Advice for Today's Colleges and Universities.

    ERIC Educational Resources Information Center

    Ortmann, Andreas

    1997-01-01

    Adam Smith's discussion of the payment modes of teachers and resulting consequences for the quality of teaching and process of curricular innovation are reviewed through the conceptual lens of modern agency theory. Smith's analysis of higher education in his day (eighteenth century) sheds light on faculty incentive and assessment problems that…

  13. James Anderson's Political Economy--His Influence on Smith and Malthus

    Microsoft Academic Search

    Renee Prendergast

    1987-01-01

    James Anderson's powerful critique of Adam Smith's position on the corn export bounty was published in 1777. It focuse d on Smith's proposition that the bounty could not lead to increased corn production because it could not increase corn's real price. Smit h's response to the critique is traced in later editions of Wealth of Nations. While Anderson's critique of

  14. 75 FR 9441 - Lucas-Smith Automotive, Inc.: Potosi, MO; Notice of Negative Determination Regarding Application...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-02

    ...TA-W-71,388] Lucas-Smith Automotive, Inc.: Potosi, MO; Notice of Negative...and former workers of Lucas- Smith Automotive, Inc., Potosi, Missouri (subject...automobiles to individual owners at an automotive dealership. The workers of the...

  15. Products of Weighted Logic Programs Shay B. Cohen, Robert J. Simmons and Noah A. Smith

    E-print Network

    Eskenazi, Maxine

    Products of Weighted Logic Programs Shay B. Cohen, Robert J. Simmons and Noah A. Smith CMU-LTI-08., Pittsburgh, PA 15213 www.lti.cs.cmu.edu © 2008, Shay B. Cohen and Robert J. Simmons and Noah A. Smith #12

  16. Connectionism and French Gender Attribution: Sokolik and Smith Re-Visited.

    ERIC Educational Resources Information Center

    Matthews, Clive A.

    1999-01-01

    Examines claims made by Sokolik and Smith (1992) about a connectionist model of acquisition of French gender attribution by reference to various results gained through a number of extensions to their network model. These results suggest a degree of caution in accepting Sokolik and Smith's conclusions.(Author/VWL)

  17. Reconsidering the Teacher Education Reform Debate: A Commentary on Cochran-Smith and Fries

    Microsoft Academic Search

    Gary D Fenstermacher

    2002-01-01

    In the November 2001 issue of Educational Researcher, Marilyn Cochran-Smith and Mary Kim Fries provided a penetrating analysis of the discourse that comprises the debate between those who advocate highly professionalized teacher preparation and those who seek simpler and more abundant routes to teacher training and certification. This commentary extends the Cochran-Smith and Fries analysis in several directions, inquiring into

  18. Dyadic Power Theory, Touch, and Counseling Psychology: A Response to Smith, Vogel, Madon, and Edwards (2011)

    ERIC Educational Resources Information Center

    Dunbar, Norah E.; Abra, Gordon

    2012-01-01

    Smith, Vogel, Madon, and Edwards' (2011) recent article tested dyadic power theory (DPT) by examining the use of touch as a compliance-gaining tactic in the conflicts of married couples. In this response, we raise a methodological issue about the touch behaviors examined by Smith et al. and also pose a theoretical critique that their test of DPT…

  19. An Alternative View of the Instructional Design Process: A Response to Smith and Boling

    ERIC Educational Resources Information Center

    Gibbons, Andrew S.; Yanchar, Stephen C.

    2010-01-01

    A recent literature review by Smith and Boling (2009) critically examines the received view of instructional design in educational technology. Smith and Boling conclude that the foundational literature characterizes design in a way that leads to a constrained understanding of design, especially by novices. They suggest that as a field we move…

  20. Unconscious Odour Conditioning 25 Years Later: Revisiting and Extending "Kirk-Smith, Van Toller and Dodd"

    ERIC Educational Resources Information Center

    Zucco, Gesualdo M.; Paolini, Michela; Schaal, Benoist

    2009-01-01

    The pioneering work by Kirk-Smith, Van Toller, and Dodd [Kirk-Smith, M. D., Van Toller, C., & Dodd, G. H. (1983). "Unconscious odour conditioning in human subjects." "Biological Psychology," 17, 221-231], established that an unnoticed odorant paired with an emotionally meaningful task can influence mood and attitudes when the odorant alone is…

  1. The Behavioural Phenotype of Smith-Magenis Syndrome: Evidence for a Gene-Environment Interaction

    ERIC Educational Resources Information Center

    Taylor, L.; Oliver, C.

    2008-01-01

    Background: Behaviour problems and a preference for adult contact are reported to be prominent in the phenotype of Smith-Magenis syndrome. In this study we examined the relationship between social interactions and self-injurious and aggressive/disruptive behaviour in Smith-Magenis syndrome to explore potential operant reinforcement of problem…

  2. Final Report - Conservation & Renewable Energy Potential Study For Smith River Rancheria

    Microsoft Academic Search

    Greg Retzlaff

    2007-01-01

    In January 2006 the Smith River Rancheria (SRR), located in Smith River, California, contracted with the team of Strategic Energy Solutions (SES) and Evergreen NRG to conduct a study for the community. The objective of the study was to identify renewable generation opportunities that would facilitate Rancheria energy independence through SRR owned and operated power projects. These generation facilities were

  3. A Disciplinary Immigrant. Alexander Smith at the University of Chicago, 1894-1911

    ERIC Educational Resources Information Center

    Cotter, Donald

    2008-01-01

    The publication in 1906 of Alexander Smith's "Introduction to general inorganic chemistry" inaugurated a decisive change in chemical pedagogy in the US, the effects of which are still evident. The nature and extent of Smith's innovations are described through a comparison of his text to its source material and contemporaries. His authoritative…

  4. Response to "Ethanol Production and Gasoline Prices: A Spurious Correlation" by Knittel and Smith

    E-print Network

    Rothman, Daniel

    Response to "Ethanol Production and Gasoline Prices: A Spurious Correlation" by Knittel and Smith Beardshear Hall, (515) 294-7612." #12;1 Response to "Ethanol Production and Gasoline Prices: A Spurious and Aaron Smith attack the paper "The Impact of Ethanol Production on US and Regional Gasoline Markets

  5. The futility of utility: how market dynamics marginalize Adam Smith

    NASA Astrophysics Data System (ADS)

    McCauley, Joseph L.

    2000-10-01

    Economic theorizing is based on the postulated, nonempiric notion of utility. Economists assume that prices, dynamics, and market equilibria are supposed to be derived from utility. The results are supposed to represent mathematically the stabilizing action of Adam Smith's invisible hand. In deterministic excess demand dynamics I show the following. A utility function generally does not exist mathematically due to nonintegrable dynamics when production/investment are accounted for, resolving Mirowski's thesis. Price as a function of demand does not exist mathematically either. All equilibria are unstable. I then explain how deterministic chaos can be distinguished from random noise at short times. In the generalization to liquid markets and finance theory described by stochastic excess demand dynamics, I also show the following. Market price distributions cannot be rescaled to describe price movements as ‘equilibrium’ fluctuations about a systematic drift in price. Utility maximization does not describe equilibrium. Maximization of the Gibbs entropy of the observed price distribution of an asset would describe equilibrium, if equilibrium could be achieved, but equilibrium does not describe real, liquid markets (stocks, bonds, foreign exchange). There are three inconsistent definitions of equilibrium used in economics and finance, only one of which is correct. Prices in unregulated free markets are unstable against both noise and rising or falling expectations: Adam Smith's stabilizing invisible hand does not exist, either in mathematical models of liquid market data, or in real market data.

  6. [Anesthetic management of a patient with Mulvihill-Smith syndrome].

    PubMed

    Kuribayashi, Junya; Yamada, Tatsuya; Morisaki, Hiroshi; Takeda, Junzo

    2007-07-01

    Mulvihill-Smith syndrome is a rare disease that belongs to progeroid syndromes. This syndrome is characterized by a senile face with an underdeveloped lower half, short stature, microcephaly, multiple pigmented nevi, immunodeficiency, hearing loss, and high-pitched voice. We report anesthetic management of a 27-year-old woman, 138 cm and 27 kg, with this syndrome, who underwent removal of mandibular cyst, partial resection of tongue and keratoplasty. Anesthesia was induced with fentanyl, propofol and vecuronium. There was difficulty in maintaining adequate ventilation with a face mask for children, and we used a mask for infants. Her Cormack grade was rated 3 but her trachea could be intubated assisted by BURP procedure. Anesthesia was maintained with sevoflurane, nitrous oxide and oxygen supplemented with fentanyl. The changes of blood pressure during anesthesia were extraordinary, suggesting the presence of advanced arteriosclerosis. The postoperative course was uneventful, with stable hemodynamics, and the patient was discharged from the hospital on 9th postoperative day. Anesthesia for Mulvihill-Smith syndrome should be performed with caution for the potential risk of difficult airway and unstable hemodynamics. PMID:17633848

  7. Novel ODE-Type Smith Predictor for Nonlinear Control Systems with Delay

    NASA Astrophysics Data System (ADS)

    Teng, Xuanxuan; Yamashita, Yuh

    This paper proposes a novel ODE-type Smith predictor for nonlinear control systems with transmission delays. The presence of time delays in the transmission of the control signals and the sensor signals may severely affect the performance of the closed-loop system and prevent the successful application of established nonlinear control methodologies. First, we investigate a backstepping interpretation of Smith predictors for linear time-variant (LTV) systems in the state space. Second, we propose a new nonlinear Smith predictor, the error dynamics of which is locally stabilized by another Smith predictor for the LTV systems. The Smith predictor can reduce the computational cost of the controller, because integral equations, which should be solved at each time in previously proposed predictive controllers, are replaced by inner-product operations.

  8. ASRF Visiting Senior Research Fellow Scheme The Adam Smith Research Foundation, based in the College of Social Sciences at the

    E-print Network

    Guo, Zaoyang

    1 ASRF Visiting Senior Research Fellow Scheme The Adam Smith Research Foundation, based in the College of Social Sciences at the University of Glasgow, brings the Enlightenment legacy of Adam Smith these aims the Adam Smith Research Foundation invites applications for VISITING SENIOR RESEARCH FELLOWS

  9. Allelic Variation in Malawi Cichlid Opsins: A Tale of Two Genera Adam R. Smith Karen L. Carleton

    E-print Network

    Carleton, Karen L.

    Allelic Variation in Malawi Cichlid Opsins: A Tale of Two Genera Adam R. Smith · Karen L. Carleton speciation (Kornfield and Smith 2000; Danley and Kocher 2001; Gen- ner and Turner 2005). Lakes Malawi00239-010-9355-x) contains supplementary material, which is available to authorized users. A. R. Smith

  10. Alfred Marshall's use of Adam Smith: Coming to grips with an aspect of Alfred Marshall's citation practice

    Microsoft Academic Search

    Peter Groenewegen

    2007-01-01

    This paper outlines Marshall's use of Smith's writings in his own published work as an aspect of Marshall's citation practice and to demonstrate Marshall's great admiration for Smith as economist. Section 2 reviews the Smith citations in Marshall's Principles of Economics', section 3 those in Marshall's other published work. The conclusion notes that this citation practice matches Marshall's great admiration

  11. SSW Library: An SIMD Smith-Waterman C/C++ Library for Use in Genomic Applications

    PubMed Central

    Zhao, Mengyao; Lee, Wan-Ping; Garrison, Erik P.; Marth, Gabor T.

    2013-01-01

    Background The Smith-Waterman algorithm, which produces the optimal pairwise alignment between two sequences, is frequently used as a key component of fast heuristic read mapping and variation detection tools for next-generation sequencing data. Though various fast Smith-Waterman implementations are developed, they are either designed as monolithic protein database searching tools, which do not return detailed alignment, or are embedded into other tools. These issues make reusing these efficient Smith-Waterman implementations impractical. Results To facilitate easy integration of the fast Single-Instruction-Multiple-Data Smith-Waterman algorithm into third-party software, we wrote a C/C++ library, which extends Farrar’s Striped Smith-Waterman (SSW) to return alignment information in addition to the optimal Smith-Waterman score. In this library we developed a new method to generate the full optimal alignment results and a suboptimal score in linear space at little cost of efficiency. This improvement makes the fast Single-Instruction-Multiple-Data Smith-Waterman become really useful in genomic applications. SSW is available both as a C/C++ software library, as well as a stand-alone alignment tool at: https://github.com/mengyao/Complete-Striped-Smith-Waterman-Library. Conclusions The SSW library has been used in the primary read mapping tool MOSAIK, the split-read mapping program SCISSORS, the MEI detector TANGRAM, and the read-overlap graph generation program RZMBLR. The speeds of the mentioned software are improved significantly by replacing their ordinary Smith-Waterman or banded Smith-Waterman module with the SSW Library. PMID:24324759

  12. Obituary: Harding Eugene (Gene) Smith, Jr., 1947-2007

    NASA Astrophysics Data System (ADS)

    Lonsdale, Carol; Soifer, Tom

    2009-01-01

    Harding Eugene Smith Junior, or Gene, as he was known to family, friends, and colleagues, passed away after an automobile accident in Encinitas, California, on 16 August 2007. He was 60 years old. Gene had recently retired from UCSD after thirty years of service. A memorial service was held at Quail Botanical Gardens in Encinitas, California, on 23 August 2007. A web page is dedicated to his memory at http://harding.smith.muchloved.com, where contributions of memories are invited. Gene was born in San Jose, California in 1947, to Harding Eugene Smith Senior, and Bernice Smith (nee Smith). Harding Smith Senior was an air-force navigator; therefore Gene spent his childhood moving from one air-force base to another. Although an only child, Gene was very close to his cousin Meg, whom he lived nearby to in Gilroy for a time, and the two were like brother and sister. The elder Harding Smith was lost in action over Cambodia in the mid-sixties. Gene was a dedicated student, a boy scout, and a Presidential Scholar. He majored in Physics at Caltech, where he also took a lively interest in the football team and the Glee Club, and was elected a House Officer. To his close friends, he was known at Caltech as Smitty, and the closest of them was Rob Drew, who gave a glimpse into that period of Gene's life at the memorial: "Gene arrived early at campus his first year, in response to an invitation to join the football team. Gene's size and features reminded the head coach of a long-forgotten player named 'Johnson.' After a few days of confusion, Gene simply replaced the name on his helmet. 'Johnson!' coach would yell, 'get in there!' If Johnson was going to get to play, Gene was going to be the best Johnson available!" Gene spent the summer of 1966 working at Kitt Peak, where his lifetime love of observing with ground-based telescopes began, though he learned some things the hard way, such as the fact that trying to squeeze 40,000 numbers onto a computer that stored only 32,000 resulted in blown fuses. In a final letter of that summer back to Drew he wrote: "My summer is now complete. I have achieved the highest pinnacle in my quest for fulfillment. Striking a blow for humanity I just blew the whole Kitt Peak CDC3200 computer system. Those fuses were nothing compared to this!" Gene's graduate work, on the metal abundances in HII regions of nearby galaxies, was done at Berkeley, where Hyron Spinrad was his thesis advisor. He loved observing and spent numerous fun nights at Lick, Kitt Peak, Cerro Tololo, Keck, and many other observatories. He joined Margaret Burbidge at UCSD for a postdoctoral fellowship, and joined the teaching faculty there in 1978. Gene spent his entire professional career at UCSD. His research ranged from the study of quasar absorptions lines to the astrophysics of Ultra-luminous Infrared Galaxies. He was a key participant in UC-wide astronomy support, including being the chair of the science-advisory committee for the Ten Meter Telescope project, which later "morphed" into the Keck Observatory. His contributions to enabling that project were both essential and unheralded. Gene was a dedicated and enthusiastic teacher. One of his favorite undergraduate classes gave him the opportunity to dress up in Renaissance garb and pretend to be Galileo, while the experiment most loved by his students was when they got to attempt to drop an egg on his head from several stories high. Gene was also an outstanding advisor and mentor, and both his first post-doc, Rick Puetter, and his last graduate student, Brian Siana, were able to attend his memorial service and provide some special memories of their experiences with him. Rick recalled a memorable trip to Cerro Tololo when they packed up two infrared spectrometers for the trip, and everything conceivable went wrong, from inspections at the airport to spectrometer parts broken on the plane and instrument failures at the observatory, to finally being completely clouded out. Brian recounted: "I spent countless cloudy nights listening to Gene's stories

  13. Smith-Purcell radiation emission in aligned nanoparticles

    SciTech Connect

    Garcia de Abajo, F. J. [Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720 (United States)

    2000-05-01

    Smith-Purcell (SP) radiation produced by interaction of fast electron beams running parallel to strings of nanoparticles is investigated. Results for the radiation emission probability and electron energy loss spectra using finite and infinite strings of Al and silica spheres are presented. Both of these quantities are obtained by solving Maxwell's equations exactly using a multipole expansion approach. The response of the spheres is described in terms of their local frequency-dependent dielectric functions. In silica, the emission probability is seen to coincide with the energy loss probability within the gap region, where the solid cannot absorb any energy. Large emission rates are predicted for Al, suggesting its possible application in tunable soft uv light generation. The dependence of the emission on the size of the spheres, the string period, and the electron energy is discussed in detail. Finite size effects are also studied for strings of 1-15 Al spheres. (c) 2000 The American Physical Society.

  14. Growth Charts for Individuals with Smith-Lemli-Opitz Syndrome

    PubMed Central

    Lee, Ryan W.Y.; McGready, John; Conley, Sandra K.; Yanjanin, Nicole M.; Nowaczyk, Ma?gorzata J.M.; Porter, Forbes D.

    2012-01-01

    Smith-Lemli-Opitz syndrome (SLOS) is a rare multiple congenital anomaly neurodevelopmental syndrome of impaired cholesterol synthesis. Growth restriction and developmental delay are very common clinical manifestations of SLOS. The degree, etiology, and consequences of growth restriction in SLOS remain an area of limited knowledge to the scientific community. There have been no studies describing the growth parameters and providing reference growth charts for individuals with SLOS. Our longitudinal data from 78 patients between the ages of 0.1 and 16 years with SLOS shows a growth restriction of about 2 standard deviations below the Centers for Disease Control (CDC) norms for age. This study represents comprehensive anthropometric data from the largest cohort available, and proposes growth charts for widespread use in the management and study of individuals with SLOS. PMID:22615010

  15. Periventricular nodular heterotopia in Smith-Magenis syndrome.

    PubMed

    Capra, Valeria; Biancheri, Roberta; Morana, Giovanni; Striano, Pasquale; Novara, Francesca; Ferrero, Giovanni Battista; Boeri, Luca; Celle, Maria Elena; Mancardi, Maria Margherita; Zuffardi, Orsetta; Parrini, Elena; Guerrini, Renzo

    2014-12-01

    Smith-Magenis syndrome (SMS) is caused by an interstitial microdeletion of chromosome 17p11.2. A few patients with the typical SMS phenotype have RAI1 gene mutations. The syndrome is characterized by minor craniofacial anomalies, short stature, sleep disturbances, behavioural and neurocognitive abnormalities, as well as variable multisystemic manifestations. Periventricular nodular heterotopia (PNH) is a genetically heterogeneous neuronal migration disorder characterized by subependymal heterotopic nodules, and is variably associated with other brain malformations, epileptic seizures and intellectual disability. Here we report on two patients harboring deletions of the 17p11.2 region in whom the SMS typical phenotype was associated with bilateral PNH. Our observations expand the spectrum of chromosomal rearrangements associated with PNH and indicate that abnormal neuronal migration may contribute to the neurocognitive phenotype of SMS. PMID:25257626

  16. Analysis of Smith-Purcell BWO with end reflections.

    SciTech Connect

    Kumar, V.; Kim, K.-J.; Accelerator Systems Division (APS); RRCAT

    2006-01-01

    We present a one-dimensional time-dependent analysis and simulation of Smith-Purcell (SP) backward wave oscillator (BWO) taking end reflections and attenuation into account. In the linear regime, we obtain an analytic solution and calculate the start current. The dependence of start current on end reflections is studied taking the attenuation due to finite conductivity into account. In this paper, we have set up Maxwell-Lorentz equations for the one-dimensional time-dependent analysis of SP-BWO including end reflection and attenuation due to finite conductivity. We have obtained a solution in the linear regime and extended the analysis to the nonlinear regime by solving the Maxwell-Lorentz equations numerically. Our analysis can be used for detailed optimization of outcoupled power and start current in SP-BWO taking end reflection and attenuation into account.

  17. Special Smith-Purcell radiation from an open resonator array

    NASA Astrophysics Data System (ADS)

    Liu, Weihao; Xu, Zhengyuan

    2014-07-01

    An interesting new physical phenomenon is uncovered—an open resonator array excited by an electron beam and able to generate a special kind of Smith-Purcell radiation (SPR). Although the frequency and direction satisfy the SPR relation, this is a single frequency radiation in a specific direction that is essentially different from ordinary SPR. The spectral density of this special radiation is also much higher than that of ordinary SPR. By means of theoretical analysis and digital simulations, the radiation mechanism together with its requirements are explored. This radiation may have great influence in modern physics and optics as it offers new ways to carry out coherent radiation generation and beam diagnostics.

  18. The analysis of convolutional codes via the extended Smith algorithm

    NASA Technical Reports Server (NTRS)

    Mceliece, R. J.; Onyszchuk, I.

    1993-01-01

    Convolutional codes have been the central part of most error-control systems in deep-space communication for many years. Almost all such applications, however, have used the restricted class of (n,1), also known as 'rate 1/n,' convolutional codes. The more general class of (n,k) convolutional codes contains many potentially useful codes, but their algebraic theory is difficult and has proved to be a stumbling block in the evolution of convolutional coding systems. In this article, the situation is improved by describing a set of practical algorithms for computing certain basic things about a convolutional code (among them the degree, the Forney indices, a minimal generator matrix, and a parity-check matrix), which are usually needed before a system using the code can be built. The approach is based on the classic Forney theory for convolutional codes, together with the extended Smith algorithm for polynomial matrices, which is introduced in this article.

  19. Sophia Smith Collection: Population and Reproductive Health Oral History Project

    NSDL National Science Digital Library

    2013-05-16

    Funded by the William and Flora Hewlett Foundation, the Population and Reproductive Health Oral History Project includes accounts of individuals throughout the world who have made valued contributions to the field. The materials here are part of the Women's History Archives at Smith College and the series includes the voices and perspectives of advocates, communication specialists, lawyers, managers, physicians, researchers, and social workers from the period 1965 to 2005. First-time visitors should read the Project History essay and then take a closer look at the several dozen interviews offered here. Those profiled here include the "mother of Asian demography," Mercedes Concepcion, and Lee Minto, the president of Planned Parenthood of Seattle-King County from 1967 to 1993. Other people interviewed here include Daniel E. Pellegrom, Nafis Sadik, and Sara Seims. It's a wonderful archive for persons interested in public health, women's studies, and a range of other crucial areas of academic study.

  20. Smith-Purcell radiation in the highly relativistic regime

    SciTech Connect

    Walsh, J.E.; Woods, K.J. [Dartmouth College, Hanover, NH (United States); Kirk, H.G. [Brookhaven National Lab., Upton, NY (United States)] [and others

    1995-12-31

    An electron moving over the surface of a diffraction grating will transfer a part of its kinetic energy to radiation via a velocity synchronous coupling with a slow space harmonic component of the field. Since the phase velocity of a slow space harmonic is less than the speed of light, the slow components decay exponentially, or evanesce, with distance above the grating and the evanescence scale is determined by the product of the relative velocity, {beta}, the relative energy, {gamma}, and the wavelength {lambda}. Thus, in the relativistic regime, good electron - grating coupling can be maintained at beam heights that are greater than the emitted wavelength. In order to explore this regime a series of experiments have been carried out with moderately energetic beams and an experiment with the 70-MeV beam at the Accelerator Test Facility is in the planning stage. The work has two basic goals: the first is to explore the characteristics of the spontaneous emission produced by the beam as it moves over the grating, and the second is to evaluate the potential of grating-coupled or Smith-Purcell free electron lasers. The spontaneous emission is of direct interest. It appears on the basis of work to date that the broad spectral distribution produced by a relativistic electron beam moving over a grating is potentially an alternative source for experiments of the type now carried out on synchrotron infrared beam lines. The grating, or a system of gratings, are also a potential alternative to the magnetic undulator and thus another basic approach to free electron laser design. The presentation will include a summary of the design of the experiment which is to be carried out on the 70-MeV A.T.F. beam line and a review of the theory of Smith-Purcell radiation in the high energy limit. Gain calculations and the role of beam quality in establishing performance limits will be discussed.

  1. Analysis of Smith-Purcell free-electron lasers

    SciTech Connect

    Kumar, Vinit; Kim, Kwang-Je [Advanced Photon Source, Argonne National Laboratory, Argonne, Illinois 60439 (United States)

    2006-02-15

    We present an analysis of the beam dynamics in a Smith-Purcell free-electron laser (FEL). In this system, an electron beam interacts resonantly with a copropagating surface electromagnetic mode near the grating surface. The surface mode arises as a singularity in the frequency dependence of the reflection matrix. Since the surface mode is confined very close to the grating surface, the interaction is significant only if the electrons are moving very close to the grating surface. The group velocity of the surface mode resonantly interacting with a low-energy electron beam is in the direction opposite to the electron beam. The Smith-Purcell FEL is therefore a backward wave oscillator in which, if the beam current exceeds a certain threshold known as start current, the optical intensity grows to saturation even if no mirrors are employed for feedback. We derive the coupled Maxwell-Lorentz equations for describing the interaction between the surface mode and the electron beam, starting from the slowly varying approximation and the singularity in the reflection matrix. In the linear regime, we derive an analytic expression for the start current and calculate the growth rate of optical power in time. The analysis is extended to the nonlinear regime by performing a one-dimensional time-dependent numerical simulation. Results of our numerical calculation compare well with the analytic calculation in the linear regime and show saturation behavior in the nonlinear regime. We find that a significant amount of power grows in the surface mode due to this interaction. Several ways to outcouple this power to freely propagating modes are discussed.

  2. Smith college secondary math and science outreach program

    SciTech Connect

    Powell, J.A.; Clark, C. [Smith College, Northhampton, MA (United States)

    1994-12-31

    The Smith College Secondary Math and Science Outreach Program works collaboratively with front-line educators to encourage young women students of all abilities, especially underrepresented and underserved minorities, to continue studying math and science throughout high school. The program includes three main components: (1) Twenty-five to thirty teams of math/science teachers and guidance counselors participate in a year-long program which begins with a three-day Current Students/Future Scientists and Engineering Workshop. This event includes a keynote address, presentations and workshops by successful women in science and engineering, and hands-on laboratory sessions. Each participant receives a stipend and free room and board. Returning to their schools, the teacher-counselor teams implement ongoing plans designed to counteract gender bias in the sciences and to alert female students to the broad range of math, science, and engineering career choices open to them. A follow-up session in the spring allows the teams to present and discuss their year-long activities. (2) TRI-ON, a day of science for 120 ninth- and tenth- grade girls from schools with a large underserved and underrepresented population, is held in early spring. Girls discover the excitement of laboratory investigation and interact with female college science and math majors. (3) Teaching Internships, initiated in 1991, involve ten to fifteen Smith College math and science majors in teaching in public schools. The teaching interns experience the rewards and challenges of classroom teaching, and they also serve as role models for younger students.

  3. Bioequivalence study of 8?mg ondansetron film-coated tablets in healthy Caucasian volunteers.

    PubMed

    Rudzki, P J; Kaza, M; Le?, A; Gilant, E; Ksyci?ska, H; Serafin-Byczak, K; Tro?, M; Raszek, J; Pi?tkowska-Chabuda, E; Skowro?ska-Smolak, M; Tarasiuk, A; Wilkowska, E; ?azowski, T

    2014-04-01

    The aim of the study was to investigate the bioequivalence of a generic product of 8?mg film-coated tablets (test) to the branded product (reference) at the same strength in order to apply for regulatory approval. The secondary objective of the study was to compare the tolerability of both products. A double blinded, randomized, cross-over, 2-period, comparative study was conducted in healthy Caucasian volunteers under fasting conditions. A single oral dose administration of the test or reference product was followed by a 7-day wash-out period. The ondansetron concentration was determined using a validated high performance liquid chromatography with a UV detection method. The 90% confidence interval of the point estimate (test over reference products) for C(max) and AUC(0-t) fell within the 80.00-125.00% acceptance range. The results of the study indicate that the film-coated tablets of Ondatron 8?mg manufactured by Tarchomi?skie Zak?ady Farmaceutyczne Polfa S.A. (test product) are bioequivalent to those of Zofran manufactured by GlaxoSmithKline Export Ltd (reference product). Both products were well tolerated. PMID:24132707

  4. Central nervous system penetration for small molecule therapeutic agents does not increase in multiple sclerosis- and Alzheimer's disease-related animal models despite reported blood-brain barrier disruption.

    PubMed

    Cheng, Ziqiang; Zhang, Jinqiang; Liu, Houfu; Li, Yi; Zhao, Yonggang; Yang, Eric

    2010-08-01

    Therapy for central nervous system (CNS) diseases requires drugs that can cross the blood-brain barrier (BBB). BBB disruption has been reported in patients with multiple sclerosis (MS) and Alzheimer's disease (AD) and the related animal models as evidenced by increased infiltration of inflammatory cells or increased staining of Igs in the central nervous system. Although CNS penetration of therapeutic agents under pathological conditions has rarely been investigated, it is commonly assumed that BBB disruption may lead to enhanced CNS penetration and also provide a "window of opportunity" through which drugs that do not normally cross BBB are able to do so. In this article, we have compared brain penetration of eight small molecules in naive animals and experimental autoimmune encephalomyelitis (EAE) mice, streptozotocin-induced mice, and TASTPM transgenic mice. The tool compounds are lipophilic transcellular drugs [GlaxoSmithKline (GSK)-A, GSK-B, GSK-C, and naproxen], lipophilic P-glycoprotein (P-gp) substrates (amprenavir and loperamide), and hydrophilic paracellular compounds (sodium fluorescein and atenolol). Our data showed that rate and extent of CNS penetration for lipophilic transcellular drugs and P-gp substrates are similar in naive and all tested animal models. The brain penetration for paracellular drugs in EAE mice is transiently increased but similar to that in naive mice at steady state. Our data suggest that, despite reported BBB disruption, CNS penetration for small molecule therapeutic agents does not increase in MS- and AD-related animal models. PMID:20427691

  5. An analysis of the attrition of drug candidates from four major pharmaceutical companies.

    PubMed

    Waring, Michael J; Arrowsmith, John; Leach, Andrew R; Leeson, Paul D; Mandrell, Sam; Owen, Robert M; Pairaudeau, Garry; Pennie, William D; Pickett, Stephen D; Wang, Jibo; Wallace, Owen; Weir, Alex

    2015-07-01

    The pharmaceutical industry remains under huge pressure to address the high attrition rates in drug development. Attempts to reduce the number of efficacy- and safety-related failures by analysing possible links to the physicochemical properties of small-molecule drug candidates have been inconclusive because of the limited size of data sets from individual companies. Here, we describe the compilation and analysis of combined data on the attrition of drug candidates from AstraZeneca, Eli Lilly and Company, GlaxoSmithKline and Pfizer. The analysis reaffirms that control of physicochemical properties during compound optimization is beneficial in identifying compounds of candidate drug quality and indicates for the first time a link between the physicochemical properties of compounds and clinical failure due to safety issues. The results also suggest that further control of physicochemical properties is unlikely to have a significant effect on attrition rates and that additional work is required to address safety-related failures. Further cross-company collaborations will be crucial to future progress in this area. PMID:26091267

  6. Gabapentin enacarbil, a gabapentin prodrug for the treatment of the neurological symptoms associated with disorders such as restless legs syndrome.

    PubMed

    Merlino, Giovanni; Serafini, Anna; Young, Jeong Jin; Robiony, Francesca; Gigli, Gian Luigi; Valente, Mariarosaria

    2009-01-01

    Restless Legs Syndrome (RLS) is a sleep-related movement disorder characterized by an urge to move the legs accompanied by unpleasant symptoms. Dopaminergic agents currently represent the first-line therapy for RLS. However, some patients are unable to continue with this pharmacological approach in the long term because of augmentation or other adverse events. Limited studies with the anticonvulsant/analgesic agent gabapentin have demonstrated that this drug might be useful in the treatment of primary and uremic RLS. Unfortunately, gabapentin has an unfavorable pharmacokinetic profile characterized by a dose-dependent bioavailability. Gabapentin enacarbil, a prodrug of gabapentin, is currently being developed by XenoPort Inc/Astellas Pharma Inc/GlaxoSmithKline plc in order to overcome this limitation. In vitro and in vivo studies have demonstrated that gabapentin enacarbil provides a dose-proportional exposure to gabapentin when orally administered. Gabapentin enacarbil has proved to be beneficial in treating RLS symptoms in several phase II and III clinical trials. In addition, these trials have demonstrated that gabapentin enacarbil is safe and well tolerated, causing transient and mild or moderate adverse events. Gabapentin enacarbil is an interesting compound, which is potentially useful in treating RLS patients who report severe adverse events under dopaminergic agents. The author concludes that additional studies are required in order to better assess the efficacy and safety of gabapentin enacarbil on RLS. PMID:19127491

  7. A practical derivatization LC/MS approach for determination of trace level alkyl sulfonates and dialkyl sulfates genotoxic impurities in drug substances.

    PubMed

    An, Jianguo; Sun, Mingjiang; Bai, Lin; Chen, Ted; Liu, David Q; Kord, Alireza

    2008-11-01

    Derivatization LC/MS methodology has been developed for the determination of a group of commonly encountered alkyl esters of sulfonates or sulfates in drug substances at low ppm levels. This general method uses trimethylamine as the derivatizing reagent for ethyl/propyl/isopropyl esters and triethylamine for methyl esters. The resulting quaternary ammonium derivatization products are highly polar (ionic) and can be retained by a hydrophilic interaction liquid chromatography (HILIC) column and readily separated from the main interfering active pharmaceutical ingredient (API) peak that is usually present at very high concentration. The method gives excellent sensitivity for all the alkyl esters at typical target analyte level of 1-2 ppm when the API samples were prepared at 5mg/mL. The recoveries at 1-2 ppm were generally above 85% for all the alkyl esters in the various APIs tested. The injection precisions of the lowest concentration standards were excellent with R.S.D.=0.4-4%. A linear range for concentrations from 0.2 to 20 ppm has been established with R(2)>or=0.99. This general method has been tested in a number of API matrices and used successfully for determination of alkyl sulfonates or dialkyl sulfates in support of API batch releases at GlaxoSmithKline. PMID:18687555

  8. A Bayesian Approach for Investigating the Risk of QT Prolongation

    PubMed Central

    Anand, Suraj P.; Ghosh, Sujit K.

    2009-01-01

    The standard approach to investigating a drug for its potential for QT prolongation is to construct a 90% two-sided (or a 95% one-sided) confidence interval (CI), for the difference in baseline corrected mean QTc (heart-rate corrected version of QT) between drug and placebo at each time-point, and to conclude non-inferiority if the upper limit for each CI is less than a pre-specified constant. An alternative approach is to base the non-inferiority inference on the largest difference in population mean QTc (baseline corrected) between drug and placebo. In this paper, we propose a Bayesian approach to resolving this problem using a Monte Carlo simulation method. We use simulated data to assess the performance of the proposed approach, discuss its advantages over the standard approach, and illustrate the method by applying it to a real data set obtained from a thorough QT study conducted at GlaxoSmithKline (GSK). PMID:21857840

  9. Combined hexavalent diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus-Haemophilus influenzae type B vaccine; Infanrix™ hexa: twelve years of experience in Italy.

    PubMed

    Baldo, Vincenzo; Bonanni, Paolo; Castro, Marcela; Gabutti, Giovanni; Franco, Elisabetta; Marchetti, Federico; Prato, Rosa; Vitale, Francesco

    2014-01-01

    Infant vaccination using 2-dose priming at 3 and 5 mo of age with a booster at 11-12 mo of age was pioneered in Italy. The 3-5-11 schedule is now used in a growing number of European countries. Infanrix™ hexa (DTPa-HBV-IPV/Hib, GlaxoSmithKline Vaccines) was first licensed for use in 2000 and has been the only pediatric hexavalent vaccine available since 2005. We reviewed available clinical trial data describing the immunogenicity of DTPa-HBV-IPV/Hib when administered at 3, 5, and 11 mo of age, and conducted an analysis of safety using global and Italian post-marketing surveillance data. In Italy, DTPa-HBV-IPV/Hib has a demonstrated safety record extending over a decade of use, it has been associated with record levels of vaccine coverage, and with sustained disease control in vaccinated cohorts. Hexavalent vaccines will continue to contribute to high vaccine coverage in Italy and across Europe. PMID:24004825

  10. Mechanisms of Acquired Resistance to Tyrosine Kinase Inhibitors in Clear - Cell Renal Cell Carcinoma (ccRCC)

    PubMed Central

    Bielecka, Zofia F; Czarnecka, Anna M; Solarek, Wojciech; Kornakiewicz, Anna; Szczylik, Cezary

    2013-01-01

    Clear - cell renal cell carcinoma (ccRCC) is a histological subtype of renal cell carcinoma - the most prevalent adult kidney cancer. Causes of ccRCC are not completely understood and therefore number of available therapies is limited. As a consequence of tumor chemo- and radioresistance as well as restrictions in offered targeted therapies, overall response rate is still unsatisfactory. Moreover, a significant group of patients (circa 1/4) does not respond to the targeted first-line treatment, while in other cases, after an initial period of stable improvement, disease progression occurs. Owing to this, more data on resistance mechanisms are needed, especially those concerning widely used, relatively lately approved and more successful than previous therapies - tyrosine kinase inhibitors (TKIs). Up to date, five TKIs have been licensed for ccRCC treatment: sunitinib (SUTENT®, Pfizer Inc.), sorafenib (Nexavar®, Bayer HealthCare/Onyx Pharmaceuticals), pazopanib (Votrient®, GlaxoSmithKline), axitinib (Inlyta®, Pfitzer Inc.) and tivozanib (AV-951®, AVEO Pharmaceuticals). Researchers have specified different subsets of tyrosine kinase inhibitors potential resistance mechanisms in clear-cell renal cell carcinoma. In most papers published until now, drug resistance is divided into intrinsic and acquired, and typically multi-drug resistance (MDR) protein is described. Herein, the authors focus on molecular analysis concerning acquired, non-genetic resistance to TKIs, with insight into specific biological processes. PMID:25152704

  11. Validation of a static Franz diffusion cell system for in vitro permeation studies.

    PubMed

    Ng, Shiow-Fern; Rouse, Jennifer J; Sanderson, Francis D; Meidan, Victor; Eccleston, Gillian M

    2010-09-01

    Over the years, in vitro Franz diffusion experiments have evolved into one of the most important methods for researching transdermal drug administration. Unfortunately, this type of testing often yields permeation data that suffer from poor reproducibility. Moreover, this feature frequently occurs when synthetic membranes are used as barriers, in which case biological tissue-associated variability has been removed as an artefact of total variation. The objective of the current study was to evaluate the influence of a full-validation protocol on the performance of a tailor-made array of Franz diffusion cells (GlaxoSmithKline, Harlow, UK) available in our laboratory. To this end, ibuprofen was used as a model hydrophobic drug while synthetic membranes were used as barriers. The parameters investigated included Franz cell dimensions, stirring conditions, membrane type, membrane treatment, temperature regulation and sampling frequency. It was determined that validation dramatically reduced derived data variability as the coefficient of variation for steady-state ibuprofen permeation from a gel formulation was reduced from 25.7% to 5.3% (n = 6). Thus, validation and refinement of the protocol combined with improved operator training can greatly enhance reproducibility in Franz cell experimentation. PMID:20842539

  12. Rotarix in developing countries: paving the way for inclusion in national childhood immunization programs in Africa.

    PubMed

    Pawinski, Robert; Debrus, Serge; Delem, Andrée; Smolenov, Igor; Suryakiran, Pemmaraju V; Han, Htay Htay

    2010-09-01

    Rotavirus gastroenteritis causes more than half a million deaths annually among children aged <5 years, the great majority of which occur in Africa and Asia. Vaccination is considered to be the most effective public health strategy to prevent rotavirus disease and to reduce the significant global burden of rotavirus gastroenteritis. Rotarix (GlaxoSmithKline Biologicals) is an oral, live attenuated rotavirus vaccine derived from a human G1P[8] rotavirus strain. Results of phase III studies in Europe, Latin America, and Asia have shown that Rotarix offers sustained high protection against severe rotavirus gastroenteritis during the first 2 years of life, when disease burden is highest, with broad protection demonstrated against each of the 5 main rotavirus types that circulate globally (G1, G2, G3, G4, and G9). Coupled with the availability of local burden of disease data and promising interim efficacy data from an ongoing study in Malawi and South Africa, this further reinforces the case for introduction of this rotavirus vaccine in national childhood immunization programs in Africa, where rotavirus-related mortality is significant. PMID:20684722

  13. Once-weekly albiglutide in the management of type 2 diabetes: patient considerations.

    PubMed

    Woodward, Heather N; Anderson, Sarah L

    2014-01-01

    This review describes the pharmacologic, pharmacokinetic, and pharmacodynamic properties of albiglutide, as well as its clinical efficacy and safety. Albiglutide is a novel, once-weekly, injectable glucagon-like peptide-1 receptor agonist for the treatment of type 2 diabetes. The European Commission recently granted marketing authorization for the drug in the European Union and on April 15, 2014, the US Food and Drug Administration approved albiglutide (Tanzeum™ [GlaxoSmithKline LLC, Wilmington, DE, USA]) to improve glycemic control in adults with type 2 diabetes. Albiglutide has been studied in Phase I, II, and III clinical trials. In the Phase III clinical trials, known as the Harmony series, weekly dosing of albiglutide demonstrated reductions in fasting plasma glucose, postprandial plasma glucose, and glycated hemoglobin, and was associated with weight loss. In all phases of the clinical trials, albiglutide administered once weekly showed a safety and tolerability profile similar to that of placebo, with mild gastrointestinal-related complaints and injection site erythema being the most commonly encountered adverse effects. Compared with pioglitazone and liraglutide, albiglutide has been shown to be clinically less effective. However, it offers the benefit of weight loss that pioglitazone does not, with fewer gastrointestinal side effects than liraglutide. As guidelines continue to advocate for patient-centered treatment strategies, once-weekly albiglutide will be an important addition to the growing armamentarium of treatment options for adults with type 2 diabetes needing target glycemic control. PMID:24926194

  14. Once-weekly albiglutide in the management of type 2 diabetes: patient considerations

    PubMed Central

    Woodward, Heather N; Anderson, Sarah L

    2014-01-01

    This review describes the pharmacologic, pharmacokinetic, and pharmacodynamic properties of albiglutide, as well as its clinical efficacy and safety. Albiglutide is a novel, once-weekly, injectable glucagon-like peptide-1 receptor agonist for the treatment of type 2 diabetes. The European Commission recently granted marketing authorization for the drug in the European Union and on April 15, 2014, the US Food and Drug Administration approved albiglutide (Tanzeum™ [GlaxoSmithKline LLC, Wilmington, DE, USA]) to improve glycemic control in adults with type 2 diabetes. Albiglutide has been studied in Phase I, II, and III clinical trials. In the Phase III clinical trials, known as the Harmony series, weekly dosing of albiglutide demonstrated reductions in fasting plasma glucose, postprandial plasma glucose, and glycated hemoglobin, and was associated with weight loss. In all phases of the clinical trials, albiglutide administered once weekly showed a safety and tolerability profile similar to that of placebo, with mild gastrointestinal-related complaints and injection site erythema being the most commonly encountered adverse effects. Compared with pioglitazone and liraglutide, albiglutide has been shown to be clinically less effective. However, it offers the benefit of weight loss that pioglitazone does not, with fewer gastrointestinal side effects than liraglutide. As guidelines continue to advocate for patient-centered treatment strategies, once-weekly albiglutide will be an important addition to the growing armamentarium of treatment options for adults with type 2 diabetes needing target glycemic control. PMID:24926194

  15. Review of 8 years of experience with Infanrix hexa (DTPa-HBV-IPV/Hib hexavalent vaccine).

    PubMed

    Zepp, Fred; Schmitt, Heinz-Josef; Cleerbout, Jan; Verstraeten, Thomas; Schuerman, Lode; Jacquet, Jeanne-Marie

    2009-06-01

    Combination vaccines that include multiple antigens within one formulation are now widely accepted as an effective means of eliciting protection against several diseases at the same time. Owing to improvements in quality and convenient modes of administration, they have become part of routine pediatric practice. Hexavalent vaccines, including diphtheria, tetanus, pertussis, hepatitis B, polio and Haemophilus influenzae type b antigens represent the latest advance in the development of combination vaccines. Over 8 years since its first licensure, this review looks at the immunogenicity, efficacy and safety profile of the only hexavalent pediatric vaccine currently in use--Infanrix hexa (diphtheria, tetanus, acellular pertusis-hepatitis B virus-inactivated poliovirus vaccine/Haemophilus influenzae type b vaccine [DTPa-HBV-IPV/Hib]; GlaxoSmithKline Biologicals, Rixensart, Belgium)--through published clinical trials and postmarketing surveillance data. These data show DTPa-HBV-IPV/Hib to be highly immunogenic and well tolerated across a range of different primary and booster vaccination schedules, as well as when administered concomitantly with other licensed vaccines (e.g., pneumococcal conjugate vaccine). Additional issues surrounding the use of hexavalent vaccines are also reviewed. PMID:19485747

  16. Vardenafil Bayer Yakuhin.

    PubMed

    Sommer, Frank; Engelmann, Udo

    2002-04-01

    Bayer is developing vardenafil, an orally active phosphodiesterase (PDE) 5 inhibitor for the potential treatment of erectile dysfunction (ED) [314382]. NDAs were filed in September 2001 in the US and Mexico [423096], and vardenafil was submitted for Canadian approval in October 2001. As of November 2001, Bayer was expecting a response from the FDA in the second half of 2002 [429499]; the EMEA accepted a filing in January 2002, following a December 2001 submission [438163]. By October 2000, phase III trials were underway in Japan [384751] and by December 2001, a Japanese NDA had been filed; at the same time an application was filed in South Africa [426526], [433060]. At this time Japanese launch was expected in 2003 [434758]. By February 2001, Bayer was also investigating a nasal formulation of vardenafil for the potential treatment of erectile dysfunction [397608]. In November 2001, Bayer and GlaxoSmithKline signed a worldwide copromotion agreement for vardenafil, under which Bayer was to be responsible for all regulatory work required to obtain approval [429499]. In February 1999, Lehman Brothers predicted a 10% probability that vardenafil would reach the market, with launch in 2002. Peak Japanese sales of US$600 million were predicted for 2014 [319225]. In May 2000, Bayer predicted peak sales of Euro900 million [397137]. In July 2001, Lehman Brothers predicted a 75% chance that vardenafil would reach the market, and forecast peak sales of US $0.85 billion worldwide; the analyst also speculated that Bayer would seek a comarketing partner [414766]. PMID:12090732

  17. New compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites: an open resource.

    PubMed

    Peña, Imanol; Pilar Manzano, M; Cantizani, Juan; Kessler, Albane; Alonso-Padilla, Julio; Bardera, Ana I; Alvarez, Emilio; Colmenarejo, Gonzalo; Cotillo, Ignacio; Roquero, Irene; de Dios-Anton, Francisco; Barroso, Vanessa; Rodriguez, Ana; Gray, David W; Navarro, Miguel; Kumar, Vinod; Sherstnev, Alexander; Drewry, David H; Brown, James R; Fiandor, Jose M; Julio Martin, J

    2015-01-01

    Using whole-cell phenotypic assays, the GlaxoSmithKline high-throughput screening (HTS) diversity set of 1.8 million compounds was screened against the three kinetoplastids most relevant to human disease, i.e. Leishmania donovani, Trypanosoma cruzi and Trypanosoma brucei. Secondary confirmatory and orthogonal intracellular anti-parasiticidal assays were conducted, and the potential for non-specific cytotoxicity determined. Hit compounds were chemically clustered and triaged for desirable physicochemical properties. The hypothetical biological target space covered by these diversity sets was investigated through bioinformatics methodologies. Consequently, three anti-kinetoplastid chemical boxes of ~200 compounds each were assembled. Functional analyses of these compounds suggest a wide array of potential modes of action against kinetoplastid kinases, proteases and cytochromes as well as potential host-pathogen targets. This is the first published parallel high throughput screening of a pharma compound collection against kinetoplastids. The compound sets are provided as an open resource for future lead discovery programs, and to address important research questions. PMID:25740547

  18. [Medication of the month. Vardenafil (Levitra)].

    PubMed

    Scheen, A J

    2003-09-01

    Vardenafil (Levitra), recently launched in Belgium by Bayer and Glaxo-SmithKline, is a new drug that potently and selectively inhibits phosphodiesterase type 5 (PDE5) in the cavernosum tissue of the penis. Inhibition of PDE5 blocks the hydrolysis of cyclic guanosine monophosphate (GMPc) and results in increased arterial blood flow leading to enlargement of the corpus cavernosum and resulting in erection. In controlled clinical trials, vardenafil at least doubled the rate of successful erections as compared to placebo, whatever the evaluation parameter considered and the subgroup of patients studied. Vardenafil is thus indicated in the treatment of patients with erectile dysfunction. It is presented as 5, 10 and 20 mg tablets and the usual dose is 10 mg to be ingested 25 to 60 minutes before sexual activity. Vardenafil has a more potent inhibitory activity of PDE5 in vitro than sildenafil or tadalafil while its pharmacokinetics in vivo is somewhat more rapid than that of the two other compounds. The dosage of vardenafil may be reduced to 5 mg (especially in older individuals) to improve tolerance or be increased up to 20 mg (especially in the presence of organic diseases aggravating erectile dysfunction) to improve efficacy. Contra-indications (co-administration with drugs increasing nitric oxide) and side-effects (headache and flushing due to vasodilatation) of vardenafil are similar to those of other PDE5 inhibitors. PMID:14626653

  19. [Narcolepsy with cataplexy: an autoimmune disease?].

    PubMed

    Jacob, Louis; Dauvilliers, Yves

    2014-12-01

    Narcolepsy type 1 (also named narcolepsy-cataplexy or hypocretin deficiency syndrome) is a rare sleep disorder characterized by excessive daytime sleepiness and cataplexy, plus frequently hypnagogic hallucinations, sleep paralysis and nocturnal sleep disturbances. Narcolepsy type 1 is an immune system-associated disease linked with the destruction of 70.000-90.000 hypocretin neurons notably involved in wakefulness. Among narcoleptic patients, 98% are positive for HLA-DQB1*06:02, a HLA class II allele, against 20-25% in general population. Individuals carrying HLA-DQB1*06:02 have an extraordinary risk to develop narcolepsy (odd ratio: 251). Other genes involved in CD4+ T cells and immune system activation as T-cell receptor ? are also associated with narcolepsy. The development of the disease is linked with environmental factors such as influenza and streptococcal infections. Narcolepsy type 1 incidence also increased in Europe following the use of Pandemrix, a 2009 H1N1 AS03-adjuvanted vaccine manufactured by GlaxoSmithKline. Interestingly, such increase was not observed with Arepanrix, another vaccine developed by GSK very similar to Pandemrix. PMID:25537044

  20. Ropinirole for the treatment of restless legs syndrome

    PubMed Central

    Kushida, Clete A

    2006-01-01

    Dopaminergic agents, anticonvulsants, benzodiazepines, opiates, and iron supplementation comprise the classes of medications commonly used to treat restless legs syndrome (RLS), which is a disorder that is estimated to affect about 1 in 10 individuals worldwide and impacts an affected patient’s sleep, mood, daytime function, and quality of life. RLS is characterized by an urge to move the legs that is worse at bedtime and at rest; the symptoms are temporarily relieved by leg movement. It is frequently accompanied by periodic limb movements during sleep (PLMS), which may independently disrupt sleep and may cause daytime drowsiness. Dopaminergic agents are considered to be first-line therapy in the management of RLS as well as PLMS. Ropinirole (Requip®, GlaxoSmithKline) is a dopamine agonist that was the first medication approved by the US Food and Drug Administration (FDA) for the treatment of moderate-to-severe primary RLS. Based on several large-scale clinical trials and open-label clinical series, this medication has been demonstrated to be effective and safe in treating the motor symptoms of RLS and improving sleep quality. PMID:19412490

  1. Effects of omega-3 fatty acid supplementation on neurocognitive functioning and mood in deployed U.S. soldiers: a pilot study.

    PubMed

    Dretsch, Michael N; Johnston, Daniel; Bradley, Ryan S; MacRae, Holden; Deuster, Patricia A; Harris, William S

    2014-04-01

    Omega-3 fatty acids (FAs) may have neuroprotective properties for psychological health and cognition. The objective of this study was to evaluate the effectiveness of omega-3 FAs (eicosapentaenoic + docosahexaenoic; Harris-Schacky [HS]-Omega-3 Index) on neuropsychological functioning among U.S. Soldiers deployed to Iraq. This randomized, double-blind, placebo-controlled trial included Soldiers between the ages of 18 and 55 years who were randomly assigned to either the active treatment group (n = 44) or placebo group (n = 34). Active treatment was 2.5 g per day of eicosapentaenoic + docosahexaenoic (Lovaza; GlaxoSmithKline, Research Triangle Park, North Carolina). The placebo was corn oil ethyl esters. HS-Omega-3 Index, a neurocognitive battery (Central Nervous System-Vital Signs, Morrisville, North Carolina), and psychological health scales were assessed at baseline and after 60 days of treatment. Although the results revealed that omega-3 FAs significantly increased the HS-Omega-3 Index (p = 0.001), there were no significant effects on indices psychological health and neurocognitive functioning by treatment group. Nevertheless, there was a significant inverse correlation between the changes in the HS-Omega-3 Index and daytime sleepiness (r = 0.30, p = 0.009). Short-term treatment with 2.5 g of omega-3 FAs did not alter measures of neurocognition or psychological health, but there was evidence of a relationship between omega-3 levels and daytime sleepiness. PMID:24690964

  2. Identification, biological characterization and pharmacophoric analysis of a new potent and selective NK1 receptor antagonist clinical candidate.

    PubMed

    Di Fabio, Romano; Alvaro, Giuseppe; Braggio, Simone; Carletti, Renzo; Gerrard, Philip A; Griffante, Cristiana; Marchioro, Carla; Pozzan, Alfonso; Melotto, Sergio; Poffe, Alessandro; Piccoli, Laura; Ratti, Emiliangelo; Tranquillini, Elvira; Trower, Michael; Spada, Simone; Corsi, Mauro

    2013-11-01

    The last two decades have provided a large weight of preclinical data implicating the neurokinin-1 receptor (NK1) and its cognate ligand substance P (SP) in a broad range of both central and peripheral disease conditions. However, to date, only the NK1 receptor antagonist aprepitant has been approved as a therapeutic and this is to prevent chemotherapy-induced nausea & vomiting (CINV). The belief remained that the full therapeutic potential of NK1 receptor antagonists had yet to be realized; therefore clinical evidence that NK1 receptor antagonists may be effective in major depression disorder, resulted in a significant further investment in discovering novel CNS penetrant druggable NK1 receptor antagonists to address this condition. At GlaxoSmithKline after the discovery of casopitant, that went on to demonstrate efficacy as a novel antidepressant in the clinic, additional novel analogues of this NK1 receptor antagonist were designed to further enhance its drug developability characteristics. Herein, we therefore describe the discovery process and the vivo pharmacological and pharmacokinetic profile of the new NK1 receptor antagonist 3a (also called orvepitant), selected as clinical candidate and further progressed into clinical studies for major depressive disorder. Moreover, molecular modeling studies enabled us to improve the pharmacophore model of the NK1 receptor antagonists with the identification of a region able to accommodate a variety of heterocycle moieties. PMID:24075145

  3. Efficient Synthesis and Anti-Tubercular Activity of a Series of Spirocycles: An Exercise in Open Science

    PubMed Central

    Badiola, Katrina A.; Quan, Diana H.; Triccas, James A.; Todd, Matthew H.

    2014-01-01

    Tuberculosis afflicts an estimated 2 billion people worldwide and causes 1.3 million deaths annually. Chemotherapeutic solutions rely on drugs developed many years ago, with only one new therapeutic having been approved in the last 40 years. Given the rise of drug-resistant strains, there is an urgent need for the development of a more robust drug development pipeline. GlaxoSmithKline recently placed the structures and activities of 177 novel anti-tubercular leads in the public domain, as well as the results of ongoing optimisation of some of the series. Since many of the compounds arose from screening campaigns, their provenance was unclear and synthetic routes were in many cases not reported. Here we present the efficient synthesis of several novel analogues of one family of the GSK compounds—termed “Spiros”—using an oxa-Pictet–Spengler reaction. The new compounds are attractive from a medicinal chemistry standpoint and some were potent against the virulent strain, suggesting this class is worthy of further study. The research was carried out using open source methodology, providing the community with full access to all raw experimental data in real time. PMID:25493550

  4. A generic approach for the determination of trace hydrazine in drug substances using in situ derivatization-headspace GC-MS.

    PubMed

    Sun, Mingjiang; Bai, Lin; Liu, David Q

    2009-02-20

    In situ derivatization-headspace GC-MS methodology has been developed for the determination of hydrazine in drug substance at low ppm levels. This general method uses acetone or acetone-d(6) as the derivatization reagent. The resulting acetone azine or acetone azine-d(12) can then be analyzed by headspace GC-MS. The method gives excellent sensitivity with a limit of quantitation (LOQ) as low as 0.1ppm when the API (active pharmaceutical ingredient) samples are prepared at 10mg per headspace injection vial. The spike recoveries of hydrazine at the 1ppm level were between 79% and 117% in various APIs tested. The precisions (%RSD) of six preparations of the hydrazine standards at the concentration of 1ppm level were typically between 2.7 and 5.6%. A linear range of concentrations from 0.1 to 10ppm has been demonstrated with R(2)> or =0.999. This general method has been tested in a number of API matrices and successfully applied to the determination of hydrazine in support of API batch releases and process chemistry at GlaxoSmithKline. PMID:19097722

  5. Impact of rotavirus vaccination in Australian children below 5 years of age

    PubMed Central

    Pendleton, Annmarie; Galic, Maja; Clarke, Christopher; Ng, Su Peing; Ledesma, Emilio; Ramakrishnan, Gunasekaran; Liu, Yanfang

    2013-01-01

    This study was conducted to assess the impact of administration of two-dose rotavirus (RV) vaccine (RIX4414; GlaxoSmithKline Vaccines) among children aged less than 5 y in three states/territories of Australia. Aggregated and de-identified data on rotavirus gastroenteritis (RVGE) and all-cause gastroenteritis (AGE) from July 1998–June 2009 were obtained from the Australian Institute of Health and Welfare database. The baseline incidence (July 1998–June 2006) of RVGE hospitalizations before RV vaccine introduction in New South Wales (NSW), the Australian Capital Territory (ACT) and the Northern Territory (NT) were 33.75, 42.93 and 288.67 per 10?000 child-years, respectively among children aged 0–11 mo. Following RV vaccine introduction in NSW, the ACT and the NT, incidence of RVGE hospitalizations reduced to 13.06, 17.35 and 47.52 per 10?000 child-years, respectively, during July 2007–June 2008 and 3.87, 8.40 and 122.79 per 10,000 child-years, respectively, during July 2008–June 2009 among children aged 0–11 mo. Reductions in RVGE and AGE were also observed in all children below 5 y of age in NSW and the ACT. Overall reduction in hospitalizations due to RVGE and AGE was observed following RV vaccine introduction into the NIP in Australia. PMID:23733041

  6. Use of MenACWY-CRM vaccine in children aged 2 through 23 months at increased risk for meningococcal disease: recommendations of the Advisory Committee on Immunization Practices, 2013.

    PubMed

    MacNeil, Jessica R; Rubin, Lorry; McNamara, Lucy; Briere, Elizabeth C; Clark, Thomas A; Cohn, Amanda C

    2014-06-20

    During its October 2013 meeting, the Advisory Committee on Immunization Practices (ACIP) recommended use of a third meningococcal conjugate vaccine, MenACWY-CRM (Menveo, Novartis), as an additional option for vaccinating infants aged 2 through 23 months at increased risk for meningococcal disease. MenACWY-CRM is the first quadrivalent meningococcal conjugate vaccine licensed for use in children aged 2 through 8 months. MenACWY-D (Menactra, Sanofi Pasteur) is recommended for use in children aged 9 through 23 months who are at increased risk for meningococcal disease, and Hib-MenCY-TT (MenHibrix, GlaxoSmithKline) is recommended for use in children aged 6 weeks through 18 months at increased risk. This report summarizes information on MenACWY-CRM administration in infants and provides recommendations for vaccine use in infants aged 2 through 23 months who are at increased risk for meningococcal disease. Because the burden of meningococcal disease in infants is low in the United States and the majority of cases that do occur are caused by serogroup B, which is not included in any vaccine licensed in the United States, only those infants who are at increased risk for meningococcal disease are recommended to receive a meningococcal vaccine. PMID:24941332

  7. [Historical aspects and new formulations of levothyroxine sodium for hypothyroidism treatment].

    PubMed

    Shacham, Elena Chertok; Ishay, Avraham; Luboshitsky, Rafael

    2013-09-01

    At the end of the 19th century symptoms and signs of hypothyroidism were described in the medical literature. At that time myxedema was a main clinical presentation of the hypothyroid patient. Today, the diagnosis of hypothyroidism is determined mainly by laboratory evaluation with most patients exhibiting only a few clinical signs of thyroid dysfunction. The treatment of hypothyroidism has progressed from partially purified extracts of bovine thyroid gland to an oral administration of synthetic hormone. Since 1981 the only thyroid hormone replacement drug approved by the Israeli Ministry of Health was the Eltroxin brand, made by GlaxoSmithKline. Levothyroxine has a narrow therapeutic range, thus a potential variance exists in the therapeutic efficacy among different levothyroxine preparations. In 2007 the Food and Drugs Administration (FDA) announced that the difference in potency of various levothyroxine brands should not exceed ten percent. In 2007 the GSK Company moved the manufacturing of Eltroxin from Canada to Germany. This resulted in a change of the inert ingredients of the drug. It is of interest to know that since the arrival of the new thyroxine formulation in the Israeli pharmaceutical market there has been a dramatic increase in reports of adverse reactions. The media coverage of adverse effects associated with Eltroxin became widespread in television, newspapers and internet sites. This led to a burden on the healthcare system, manifesting itself by an increase in thyroid blood tests, physician follow-up visits, as well as the importing and distribution of a new brand of thyroxine. PMID:24364099

  8. A local construction of the Smith normal form of a matrix polynomial

    SciTech Connect

    Wilkening, Jon; Yu, Jia

    2008-09-01

    We present an algorithm for computing a Smith form with multipliers of a regular matrix polynomial over a field. This algorithm differs from previous ones in that it computes a local Smith form for each irreducible factor in the determinant separately and then combines them into a global Smith form, whereas other algorithms apply a sequence of unimodular operations to the original matrix row by row (or column by column). The performance of the algorithm in exact arithmetic is reported for several test cases.

  9. The eleventh reported case of Mulvihill-Smith syndrome in the literature

    PubMed Central

    2014-01-01

    Background The Mulvihill-Smith Syndrome was first recognized in 1975. After the recognition of the Mulvihill-Smith Syndrome, ten cases have been described. Case presentation This article describes the eleventh case of this syndrome in a male patient, 24 years-old with short stature and microcephaly with mild cognitive impairment, deafness and allergic conjunctivitis. The patient was hospitalized several times for repeated infections, and the presence of multiple melanocytic nevi on his skin was noticed. Conclusions Based on the entire set of signs and symptoms presented in our study, it was diagnosed the patient with Mulvihill-Smith Syndrome. PMID:24397283

  10. Camp H.M. Smith and Navy Public Works Center Manana Title ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Camp H.M. Smith and Navy Public Works Center Manana Title VII (Capehart) Housing, U-Shaped Two-Bedroom Single-Family Type 6, Birch Circle, Elm Drive, Elm Circle, and Date Drive, Pearl City, Honolulu County, HI

  11. Camp H.M. Smith and Navy Public Works Center Manana Title ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Camp H.M. Smith and Navy Public Works Center Manana Title VII (Capehart) Housing, Three-Bedroom Single-Family Types 8 and 11, Birch Circle, Elm Drive, Elm Circle, and Date Drive, Pearl City, Honolulu County, HI

  12. Camp H.M. Smith and Navy Public Works Center Manana Title ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Camp H.M. Smith and Navy Public Works Center Manana Title VII (Capehart) Housing, U-Shaped Three-Bedroom Duplex Type 4, Acacia Road, Birch Circle, Cedar Drive and Elm Drive, Pearl City, Honolulu County, HI

  13. Camp H.M. Smith and Navy Public Works Center Manana Title ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Camp H.M. Smith and Navy Public Works Center Manana Title VII (Capehart) Housing, Four-Bedroom, Single-Family Type 10, Birch Circle, Elm Drive, Elm Circle, and Date Drive, Pearl City, Honolulu County, HI

  14. Camp H.M. Smith and Navy Public Works Center Manana Title ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Camp H.M. Smith and Navy Public Works Center Manana Title VII (Capehart) Housing, Three-Bedroom Single-Family Type 7, Birch Circle, Elm Drive, Elm Circle, and Date Drive, Pearl City, Honolulu County, HI

  15. Modeling Language Acquisition in Atypical Phenotypes Michael S. C. Thomas and Annette Karmiloff-Smith

    E-print Network

    Yu, Chen

    -Smith Institute of Child Health An increasing number of connectionist models have been proposed to explain to a series of new simulations investigating past-tense formation in Williams syndrome. This syndrome

  16. Single-longitudinal-mode fiber optic parametric oscillator based on Smith predictor control scheme

    NASA Astrophysics Data System (ADS)

    Salehiomran, Ali; Modirnia, Seyed-Rahi; Boulet, Benoit; Rochette, Martin

    2011-08-01

    Fiber optical parametric oscillators are laser sources with multiple longitudinal modes arising from their cavity length reaching several tens of meters. To reduce the noise due to multimode beating, the spacing between neighboring modes is increased using a Smith predictor internal control scheme. The Smith predictor utilizes a model of the dynamic behaviour of the system to deal with pure time delay and eliminate the effect of the delay in the overall closed-loop system. Applying the smith predictor, the system can be made to operate in a single-longitudinal mode, removing the excess modes. In this paper a linear model for operation of parametric oscillator is proposed and based on that transfer function of Smith predictor enhanced parametric oscillator is established. Numerical analysis of resulting transfer function will lead us toward single-longitudinal mode operation.

  17. George E. KidderSmith, April 1945, Photograph #1338. VIEW OF BUILDING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    George E. Kidder-Smith, April 1945, Photograph #133-8. VIEW OF BUILDING 23, FRONT SIDE FROM ACROSS COURTYARD, FACING WEST - Roosevelt Base, Auditorium-Gymnasium, West Virginia Street between Richardson & Reeves Avenues, Long Beach, Los Angeles County, CA

  18. George E. KidderSmith, photographer, April 1945, Photograph #1101. VIEW OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    George E. Kidder-Smith, photographer, April 1945, Photograph #110-1. VIEW OF BUILDING 23, SOUTH SIDE WITH ARCADE, FACING NORTHWEST - Roosevelt Base, Auditorium-Gymnasium, West Virginia Street between Richardson & Reeves Avenues, Long Beach, Los Angeles County, CA

  19. Paul Edward Smith Department of Biochemistry, 36 Willard Hall, Kansas State University

    E-print Network

    Smith, Paul E.

    Paul Edward Smith Department of Biochemistry, 36 Willard Hall, Kansas State University Manhattan, 1985 Research Experience Assistant Professor, 1996 to present, Department of Biochemistry, Kansas State University, Manhattan, Kansas. Research Assistant Professor, 1993 to 1996, Department of Chemistry

  20. Vehicle Placement to Intercept Moving Targets Shaunak D. Bopardikar Stephen L. Smith Francesco Bullo

    E-print Network

    Bullo, Francesco

    that the target either moves with fixed speed and in a fixed direction or moves to maximize the vertical height. Smith is with the Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute

  1. Measuring short electron bunch lengths using coherent Smith-Purcell radiation

    DOEpatents

    Nguyen, D.C.

    1999-03-30

    A method is provided for directly determining the length of sub-picosecond electron bunches. A metallic grating is formed with a groove spacing greater than a length expected for the electron bunches. The electron bunches are passed over the metallic grating to generate coherent and incoherent Smith-Purcell radiation. The angular distribution of the coherent Smith-Purcell radiation is then mapped to directly deduce the length of the electron bunches. 8 figs.

  2. Digital geologic map of Fort Smith Quadrangle, east-central Oklahoma

    USGS Publications Warehouse

    Cederstrand, J.R.

    1997-01-01

    This data set consists of digital data and accompanying documentation of the surficial geology of the 1:250,000-scale Fort Smith quadrangle, Oklahoma. The original data are from the Geologic Map, sheet 1 of 4, included in the Oklahoma Geological Survey publication, Reconnaissance of the water resources of the Fort Smith quadrangle, east-central Oklahoma, Hydrologic Atlas 1, Marcher, 1969. The geology was compiled by M.V. Marcher, in 1967.

  3. Measuring short electron bunch lengths using coherent smith-purcell radiation

    SciTech Connect

    Nguyen, Dinh C. (Los Alamos, NM)

    1999-01-01

    A method is provided for directly determining the length of sub-picosecond electron bunches. A metallic grating is formed with a groove spacing greater than a length expected for the electron bunches. The electron bunches are passed over the metallic grating to generate coherent and incoherent Smith-Purcell radiation. The angular distribution of the coherent Smith-Purcell radiation is then mapped to directly deduce the length of the electron bunches.

  4. Unconscious odour conditioning 25 years later: Revisiting and extending ‘Kirk-Smith, Van Toller and Dodd’

    Microsoft Academic Search

    Gesualdo M. Zucco; Michela Paolini; Benoist Schaal

    2009-01-01

    The pioneering work by Kirk-Smith, Van Toller, and Dodd [Kirk-Smith, M. D., Van Toller, C., & Dodd, G. H. (1983). Unconscious odour conditioning in human subjects. Biological Psychology, 17, 221–231], established that an unnoticed odorant paired with an emotionally meaningful task can influence mood and attitudes when the odorant alone is re-encountered subsequently. This study was particularly important in highlighting

  5. Smith-Doxey Classification, Fiber Testing and Problems of the Cotton Trade.

    E-print Network

    Hunt, Robert L.

    1956-01-01

    Smith-Doxi Class;fication, Fiber Testing and Problems of the Cotton Trade TEXAS AGRICULTURAL EXPERIMENT STATION R. D. LEWIS, DIRECTOR. COLLEGE STATION. TEXAS SUMMARY Members of the Texas Cotton Association were either interviewed personally... or we mailed a questionnaire in June 1955 and were asked the following questions: 1. To what extent are Texas cotton merchants buying cotton on the basis of Smith-Dox classification and what are their chief criticisms of this classing service? 2...

  6. Distribution of capsular materials on the cell wall surface of strain Smith diffuse of Staphylococcus aureus.

    PubMed Central

    Arizono, T; Umeda, A; Amako, K

    1991-01-01

    The fine structure of the capsule of Staphylococcus aureus Smith diffuse was examined by the technique of freeze-substitution and immunoelectron microscopy. The cell surface was covered with a thick layer consisting of fine fibrous structures which were absent from an unencapsulated strain, Smith compact. Anti-teichoic acid antibody did not react with this surface layer but reacted with the surface of strain Smith compact. Anti-capsular antibody, made from the serum of a rabbit immunized with strain Smith diffuse and specific absorption with unencapsulated strain Wood 46, reacted with the fibrous layer of the Smith diffuse strain. Since the anti-teichoic acid antibody did not react with the encapsulated strain Smith diffuse, the capsular layer acts as a barrier to penetration of the anti-teichoic acid antibody through the capsular layer. A portion of a few cell surfaces of the encapsulated strain remained accessible to the anti-teichoic acid antibody. The capsular layer in this portion of the cell surface was thin, and this surface seemed to be a new cell wall surface created by the cell separation. Images PMID:2066333

  7. A comparison of free weight squat to Smith machine squat using electromyography.

    PubMed

    Schwanbeck, Shane; Chilibeck, Philip D; Binsted, Gordon

    2009-12-01

    The purpose of this experiment was to determine whether free weight or Smith machine squats were optimal for activating the prime movers of the legs and the stabilizers of the legs and the trunk. Six healthy participants performed 1 set of 8 repetitions (using a weight they could lift 8 times, i.e., 8RM, or 8 repetition maximum) for each of the free weight squat and Smith machine squat in a randomized order with a minimum of 3 days between sessions, while electromyographic (EMG) activity of the tibialis anterior, gastrocnemius, vastus medialis, vastus lateralis, biceps femoris, lumbar erector spinae, and rectus abdominus were simultaneously measured. Electromyographic activity was significantly higher by 34, 26, and 49 in the gastrocnemius, biceps femoris, and vastus medialis, respectively, during the free weight squat compared to the Smith machine squat (p < 0.05). There were no significant differences between free weight and Smith machine squat for any of the other muscles; however, the EMG averaged over all muscles during the free weight squat was 43% higher when compared to the Smith machine squat (p < 0.05). The free weight squat may be more beneficial than the Smith machine squat for individuals who are looking to strengthen plantar flexors, knee flexors, and knee extensors. PMID:19855308

  8. Cardiovascular malformations in Smith-Lemli-Opitz syndrome

    SciTech Connect

    Lin, A.E.; Ardinger, H.H.; Ardinger, R.H. Jr. [Univ. of Kansas, Kansas City, KS (United States)] [and others] [Univ. of Kansas, Kansas City, KS (United States); and others

    1997-01-31

    We reviewed 215 patients (59 new, 156 from the literature) with Smith-Lemli-Opitz syndrome (SLOS), and found that 95 (44%) had a cardiovascular malformation (CVM). Classifying CVMs by disordered embryonic mechanisms, there were 5 (5.3%) class I (ectomesenchymal tissue migration abnormalities), 56 (58.9%) class II (abnormal intracardiac blood flow), 25 (26.3%) class IV (abnormal extracellular matrix), and 5 (5.3%) class V (abnormal targeted growth). Comparing the frequencies of individual CVMs in this series with a control group (the Baltimore-Washington Infant Study), there were 6 individual CVMs which showed a significant difference from expected values. When frequencies of CVMs in SLOS were analyzed by mechanistic class, classes IV and V were significantly more frequent, and class I significantly less frequent, than the control group. Although CVMs in SLOS display mechanistic heterogeneity, with an overall predominance of class II CVMs, the developmental error appears to favor alteration of the cardiovascular developmental mechanisms underlying atrioventricular canal and anomalous pulmonary venous return. This information should assist the clinical geneticist evaluating a patient with possible SLOS, and should suggest research direction for the mechanisms responsible for the SLOS phenotype. 102 refs., 1 fig., 7 tabs.

  9. Basic repository environmental assessment design basis: Deaf Smith County site

    SciTech Connect

    Not Available

    1988-03-01

    This study examines the engineering factors and costs associated with the construction, operation, and decommissioning of a high-level nuclear waste repository in salt in the Palo Duro Basin in Deaf Smith County, Texas. The study assumes a repository capacity of 36,000 metric tons of heavy metal (MTHM) of unreprocessed spent fuel and 36,000 MTHM of commercial high-level reprocessing waste, along with 7,020 canisters of defense high-level reprocessing waste and associated quantities or remote- and contact-handled transuranic waste (TRU). With the exception of TRU, all the waste forms are placed in 300- to 1000-year-life carbon-steel waste packages in a collocated waste handling and packaging facility (WHPF), which is also described. The construction, operation, and decommissioning of the proposed repository is estimated to cost approximately $4.64 billion. Costs include those for the collocate WHPF, engineering, and contingency, but exclude waste form assembly and shipment to the site and waste package fabrication and shipment to the site. These costs reflect the relative average wage rates of the region, the relatively easy access to the site, and the relatively weak nature of the salt at this site. Construction would require an estimated 7 to 7.5 years. Engineering factors and costs are not strongly influenced by environmental considerations. 62 refs., 24 figs., 20 tabs.

  10. Risk should be objectively defined: reply to Zentall and Smith.

    PubMed

    Sueur, Cédric; Pelé, Marie

    2015-07-01

    Zentall and Smith (2014) have published a comment on Pelé and Sueur (Anim Cogn 16:543-556, 2013) in which they raise two issues, one about the definition of risk and a second concerning the optimality of decisions. When making a choice, subjects are faced not only with several possible alternatives but also with the risk of opting for an unsuitable choice which depends on several variables (context, internal state, knowledge and perception). Although it is true that animals might learn about their environment and adapt their decisions to the context and to their experience, strong constraints make some behavioural traits stable over individual lifetime and even generations. We therefore consider that experience has limited impact on the variability of temporal discounting. These behavioural traits make the difference between perceived and actual risk. If the perceived risk strongly differs from the actual risk, a decision should be considered as suboptimal. If we want to lead individual and collective cognition to a common decision science, it is crucial to use the same definitions for terms implied in decision-making. PMID:25771966

  11. Smith River Rancheria's Development of an Energy Organization Investigation

    SciTech Connect

    W.G Buehler & Associates

    2007-08-27

    Smith River Rancheria (SRR), for some time, has had a strong commitment to attaining energy selfsufficiency, to reduce overall energy costs and concurrently initiate economic development within the community. Early on it was recognized that the development of an energy organization was important and for this reason was made part of the SRR's strategic review not only for economic development but also the reduction of energy costs. Towards this end, SRR retained Werner G. Buehler of W.G. Buehler & Associates to investigate the many phases or steps required to establish such an energy organization and determine, if in fact, it could benefit the Tribe. The basic phases are delineated as: (1) Identify potential sources of wholesale power and transmission paths; (2) Evaluating the various forms of energy organizations; (3) Determining the benefits (and disadvantages) of each form of organization; (4) Gathering costs to organize and operate the selected form or energy organization; (5) Performing an economic analysis of forming and operating an energy organization; and (6) Develop an implementation plan.

  12. Peroxisomal cholesterol biosynthesis and Smith-Lemli-Opitz syndrome

    SciTech Connect

    Weinhofer, Isabelle [Center for Brain Research, Medical University of Vienna, Vienna (Austria); Kunze, Markus [Center for Brain Research, Medical University of Vienna, Vienna (Austria); Stangl, Herbert [Department of Medical Chemistry, Medical University of Vienna, Vienna (Austria); Porter, Forbes D. [National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD (United States); Berger, Johannes [Center for Brain Research, Medical University of Vienna, Vienna (Austria)]. E-mail: johannes.berger@meduniwien.ac.at

    2006-06-23

    Smith-Lemli-Opitz syndrome (SLOS), caused by 7-dehydrocholesterol-reductase (DHCR7) deficiency, shows variable severity independent of DHCR7 genotype. To test whether peroxisomes are involved in alternative cholesterol synthesis, we used [1-{sup 14}C]C24:0 for peroxisomal {beta}-oxidation to generate [1-{sup 14}C]acetyl-CoA as cholesterol precursor inside peroxisomes. The HMG-CoA reductase inhibitor lovastatin suppressed cholesterol synthesis from [2-{sup 14}C]acetate and [1-{sup 14}C]C8:0 but not from [1-{sup 14}C]C24:0, implicating a peroxisomal, lovastatin-resistant HMG-CoA reductase. In SLOS fibroblasts lacking DHCR7 activity, no cholesterol was formed from [1-{sup 14}C]C24:0-derived [1-{sup 14}C]acetyl-CoA, indicating that the alternative peroxisomal pathway also requires this enzyme. Our results implicate peroxisomes in cholesterol biosynthesis but provide no link to phenotypic variation in SLOS.

  13. The Futility of Utility: how market dynamics marginalize Adam Smith

    E-print Network

    Joseph L. McCauley

    2000-02-02

    Econometrics is based on the nonempiric notion of utility. Prices, dynamics, and market equilibria are supposed to be derived from utility. Utility is usually treated by economists as a price potential, other times utility rates are treated as Lagrangians. Assumptions of integrability of Lagrangians and dynamics are implicitly and uncritically made. In particular, economists assume that price is the gradient of utility in equilibrium, but I show that price as the gradient of utility is an integrability condition for the Hamiltonian dynamics of an optimization problem in econometric control theory. One consequence is that, in a nonintegrable dynamical system, price cannot be expressed as a function of demand or supply variables. Another consequence is that utility maximization does not describe equiulibrium. I point out that the maximization of Gibbs entropy would describe equilibrium, if equilibrium could be achieved, but equilibrium does not describe real markets. To emphasize the inconsistency of the economists' notion of 'equilibrium', I discuss both deterministic and stochastic dynamics of excess demand and observe that Adam Smith's stabilizing hand is not to be found either in deterministic or stochastic dynamical models of markets, nor in the observed motions of asset prices. Evidence for stability of prices of assets in free markets simply has not been found.

  14. Efecto biocida del «barbasco» Lonchocarpus utilis (Smith,1930) como regulador de larvas de mosquitos Biocidal effect of «barbasco» Lonchocarpus utilis (Smith,1930) as regulator of mosquitoes larvae

    Microsoft Academic Search

    Carlos Mariños; Julia Castro; Diana Nongrados

    2004-01-01

    Seven bioassays in laboratory were carried out in order to evaluate the biocidal capacity of Lonchocarpus utilis (Smith,1930) «barbasco» on 7000 larvae of third and fourth stage of Anopheles benarrochi (Gabaldon,1941), main vector of malaria in Yurimaguas and Loreto. The biocidal activity was probed with two types of quality water. Fresh roots of L. utilis were processed by Vílchez (1993)

  15. Conical diffraction effect in optical and x-ray Smith-Purcell radiation

    NASA Astrophysics Data System (ADS)

    Sergeeva, D. Yu.; Tishchenko, A. A.; Strikhanov, M. N.

    2015-05-01

    Smith-Purcell radiation is a well-known phenomenon, which provides a noninvasive scheme for diagnostics of charged particle beams and is used as an effective source of electromagnetic waves, e.g., in the orotron, the free electron laser, etc. In this paper we develop the theory of Smith-Purcell radiation (SPR) for the little-investigated case of arbitrary angles between the charged particle trajectories and the rulings of a grating. The effect of conical diffraction arising here changes drastically the space distribution of the radiation. By contrast to the only existing approach, described by Haeberle et al. [Phys. Rev. E 55, 4675 (1997)], which requires difficult numerical calculations, we give a fully analytic theory of SPR. Also, in this paper we present for the first time the theory of x-ray Smith-Purcell radiation. Evanescent waves on the surface are shown to lead to strong enhancement of Smith-Purcell radiation, through a resonant mechanism. The results are important for the description of real divergent high-brightness beams and for the development of novel noninvasive diagnostic schemes based on the Smith-Purcell effect.

  16. Searching for Dark Matter Annihilation in the Smith High-velocity Cloud

    NASA Astrophysics Data System (ADS)

    Drlica-Wagner, Alex; Gómez-Vargas, Germán A.; Hewitt, John W.; Linden, Tim; Tibaldo, Luigi

    2014-07-01

    Recent observations suggest that some high-velocity clouds may be confined by massive dark matter halos. In particular, the proximity and proposed dark matter content of the Smith Cloud make it a tempting target for the indirect detection of dark matter annihilation. We argue that the Smith Cloud may be a better target than some Milky Way dwarf spheroidal satellite galaxies and use ?-ray observations from the Fermi Large Area Telescope to search for a dark matter annihilation signal. No significant ?-ray excess is found coincident with the Smith Cloud, and we set strong limits on the dark matter annihilation cross section assuming a spatially extended dark matter profile consistent with dynamical modeling of the Smith Cloud. Notably, these limits exclude the canonical thermal relic cross section (~ 3 × 10-26 cm3 s-1) for dark matter masses <~ 30 GeV annihilating via the b \\bar{b} or ?+?- channels for certain assumptions of the dark matter density profile; however, uncertainties in the dark matter content of the Smith Cloud may significantly weaken these constraints.

  17. Searching for Dark Matter Annihilation in the Smith High-Velocity Cloud

    E-print Network

    Alex Drlica-Wagner; German A. Gomez-Vargas; John W. Hewitt; Tim Linden; Luigi Tibaldo

    2014-06-30

    Recent observations suggest that some high-velocity clouds may be confined by massive dark matter halos. In particular, the proximity and proposed dark matter content of the Smith Cloud make it a tempting target for the indirect detection of dark matter annihilation. We argue that the Smith Cloud may be a better target than some Milky Way dwarf spheroidal satellite galaxies and use gamma-ray observations from the Fermi Large Area Telescope to search for a dark matter annihilation signal. No significant gamma-ray excess is found coincident with the Smith Cloud, and we set strong limits on the dark matter annihilation cross section assuming a spatially-extended dark matter profile consistent with dynamical modeling of the Smith Cloud. Notably, these limits exclude the canonical thermal relic cross section ($\\sim 3\\times10^{-26}{\\rm cm}^{3}{\\rm s}^{-1}$) for dark matter masses $\\lesssim 30$ GeV annihilating via the $b \\bar b$ or $\\tau^{+}\\tau^{-}$ channels for certain assumptions of the dark matter density profile; however, uncertainties in the dark matter content of the Smith Cloud may significantly weaken these constraints.

  18. VizieR Online Data Catalog: Optical and UV colors of Coma galaxies (Smith+, 2012)

    NASA Astrophysics Data System (ADS)

    Smith, R. J.; Lucey, J. R.; Carter, D.

    2013-03-01

    Our approach is to measure UV/optical colours for galaxies drawn from a catalogue of galaxies with measured spectroscopic ages and metallicities. Full details of the spectroscopy are given in related papers (Smith et al. 2012MNRAS.419.3167S; Smith et al., in preparation). Broadly the parent sample comprises spectra for 242 bright Coma cluster members from SDSS (analysed in Price et al. 2010, Cat. J/MNRAS/411/2558) and 169 fainter members observed using long integrations with Hectospec at the 6.5-m MMT. The MMT sample is an extended version of that reported by Smith et al. (2009, cat. J/MNRAS/392/1265). Velocity dispersions were compiled from a variety of literature sources, supplemented with new observations from VLT/FLAMES, and combined using observations from multiple data sources to determine relative systematic offsets. (2 data files).

  19. Groundwater and surface-water interaction within the upper Smith River Watershed, Montana 2006-2010

    USGS Publications Warehouse

    Caldwell, Rodney R.; Eddy-Miller, Cheryl A.

    2013-01-01

    The 125-mile long Smith River, a tributary of the Missouri River, is highly valued as an agricultural resource and for its many recreational uses. During a drought starting in about 1999, streamflow was insufficient to meet all of the irrigation demands, much less maintain streamflow needed for boating and viable fish habitat. In 2006, the U.S. Geological Survey, in cooperation with the Meagher County Conservation District, initiated a multi-year hydrologic investigation of the Smith River watershed. This investigation was designed to increase understanding of the water resources of the upper Smith River watershed and develop a detailed description of groundwater and surface-water interactions. A combination of methods, including miscellaneous and continuous groundwater-level, stream-stage, water-temperature, and streamflow monitoring was used to assess the hydrologic system and the spatial and temporal variability of groundwater and surface-water interactions. Collectively, data are in agreement and show: (1) the hydraulic connectedness of groundwater and surface water, (2) the presence of both losing and gaining stream reaches, (3) dynamic changes in direction and magnitude of water flow between the stream and groundwater with time, (4) the effects of local flood irrigation on groundwater levels and gradients in the watershed, and (5) evidence and timing of irrigation return flows to area streams. Groundwater flow within the alluvium and older (Tertiary) basin-fill sediments generally followed land-surface topography from the uplands to the axis of alluvial valleys of the Smith River and its tributaries. Groundwater levels were typically highest in the monitoring wells located within and adjacent to streams in late spring or early summer, likely affected by recharge from snowmelt and local precipitation, leakage from losing streams and canals, and recharge from local flood irrigation. The effects of flood irrigation resulted in increased hydraulic gradients (increased groundwater levels relative to stream stage) or even reversed gradient direction at several monitoring sites coincident with the onset of nearby flood irrigation. Groundwater-level declines in mid-summer were due to groundwater withdrawals and reduced recharge from decreased precipitation, increased evapotranspiration, and reduced leakage in some area streams during periods of low flow. Groundwater levels typically rebounded in late summer, a result of decreased evapotranspiration, decreased groundwater use for irrigation, increased flow in losing streams, and the onset of late-season flood irrigation at some sites. The effect of groundwater and surface-water interactions is most apparent along the North and South Forks of the Smith River where the magnitude of streamflow losses and gains can be greater than the magnitude of flow within the stream. Net gains consistently occurred over the lower 15 miles of the South Fork Smith River. A monitoring site near the mouth of the South Fork Smith River gained (flow from the groundwater to the stream) during all seasons, with head gradients towards the stream. Two upstream sites on the South Fork Smith River exhibited variable conditions that ranged from gaining during the spring, losing (flowing from the stream to the groundwater) during most of the summer as groundwater levels declined, and then approached or returned to gaining conditions in late summer. Parts of the South Fork Smith River became dry during periods of losing conditions, thus classifying this tributary as intermittent. The North Fork Smith River is highly managed at times through reservoir releases. The North Fork Smith River was perennial throughout the study period although irrigation diversions removed a large percentage of streamflow at times and losing conditions persisted along a lower reach. The lowermost reach of the North Fork Smith River near its mouth transitioned from a losing reach to a gaining reach throughout the study period. Groundwater and surface-water interactions occur downstream from the confluence of the North and South F

  20. Geology, paleoclimatology and the evolution of the kidney: some explorations into the legacy of Homer Smith.

    PubMed

    Kooman, Jeroen P

    2012-01-01

    The aim of this review is to perform an overview of the relation between kidney development in different species and new developments in plate tectonics and paleoclimatology, which likely had a remarkable effect on evolution. The review follows the ideas of Homer Smith, but adds new data on the subjects which were unknown in Homer Smith's time. The structure and function of the kidney are a result of hundreds of millions of years of evolution, in which adaptations had to be made in response to environmental demands while maintaining the kidney's integrated function. The ideas of Homer Smith have greatly contributed to our understanding of this process, and continue to be of relevance both for researchers as well as physicians working in the field of kidney disease. PMID:22572704

  1. Maternal apo E genotype is a modifier of the Smith-Lemli-Opitz syndrome

    PubMed Central

    Witsch-Baumgartne..., M; Gruber, M; Kraft, H; Rossi, M; Clayton, P; Giros, M; Haas, D; Kelley, R; Krajewska-Walasek, M; Utermann, G

    2004-01-01

    Background: Smith-Lemli-Opitz syndrome (MIM 270400) is an autosomal recessive malformation and mental retardation syndrome that ranges in clinical severity from minimal dysmorphism and mild mental retardation to severe congenital anomalies and intrauterine death. Smith-Lemli-Opitz syndrome is caused by mutations in the ?7 sterol-reductase gene (DHCR7; EC 1.3.1.21), which impair endogenous cholesterol biosynthesis and make the growing embryo dependent on exogenous (maternal) sources of cholesterol. We have investigated whether apolipoprotein E, a major component of the cholesterol transport system in human beings, is a modifier of the clinical severity of Smith-Lemli-Opitz syndrome. Method: Common apo E, DHCR7, and LDLR genotypes were determined in 137 biochemically characterised patients with Smith-Lemli-Opitz syndrome and 59 of their parents. Results: There was a significant correlation between patients' clinical severity scores and maternal apo E genotypes (p = 0.028) but not between severity scores and patients' or paternal apo E genotypes. In line with their effects on serum cholesterol levels, the maternal apo ?2 genotypes were associated with a severe Smith-Lemli-Opitz syndrome phenotype, whereas apo E genotypes without the ?2 allele were associated with a milder phenotype. The correlation of maternal apo E genotype with disease severity persisted after stratification for DHCR7 genotype. There was no association of Smith-Lemli-Opitz syndrome severity with LDLR gene variation. Conclusions: These results suggest that the efficiency of cholesterol transport from the mother to the embryo is affected by the maternal apo E genotype and extend the role of apo E and its disease associations to modulation of embryonic development and malformations. PMID:15286151

  2. 37 CFR 1.130 - Affidavit or declaration of attribution or prior public disclosure under the Leahy-Smith America...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...attribution or prior public disclosure under the Leahy-Smith America Invents Act. 1.130 Section 1.130 Patents, Trademarks...attribution or prior public disclosure under the Leahy-Smith America Invents Act. (a) Affidavit or declaration of...

  3. 37 CFR 1.130 - Affidavit or declaration of attribution or prior public disclosure under the Leahy-Smith America...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...attribution or prior public disclosure under the Leahy-Smith America Invents Act. 1.130 Section 1.130 Patents, Trademarks...attribution or prior public disclosure under the Leahy-Smith America Invents Act. (a) Affidavit or declaration of...

  4. MOLECULAR-BASED STUDIES IN SONGBIRDS E.D. Jarvis V.A. Smith K. Wada M.V. Rivas

    E-print Network

    Smulders, Tom

    MOLECULAR-BASED STUDIES IN SONGBIRDS E.D. Jarvis Æ V.A. Smith Æ K. Wada Æ M.V. Rivas M. McElroy Æ T Physiol A (2002) 188: 961­980 DOI 10.1007/s00359-002-0358-y E.D. Jarvis (&) Æ V.A. Smith Æ K. Wada Æ M. Mc

  5. 78 FR 16182 - Changes To Implement the First Inventor To File Provisions of the Leahy-Smith America Invents Act...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-14

    ...Changes To Implement the First Inventor To File Provisions of the Leahy-Smith America...the changes in the first inventor to file provisions of the Leahy-Smith America Invents Act (AIA) (First Inventor to File Final Rule). Due to a technical...

  6. 77 FR 43759 - Examination Guidelines for Implementing the First-Inventor-to-File Provisions of the Leahy-Smith...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-26

    ...Implementing the First-Inventor-to- File Provisions of the Leahy-Smith America...concerning the first-inventor-to-file (FITF) provisions of the Leahy-Smith...invent'' system to a ``first inventor to file'' system, treats United States...

  7. 78 FR 11059 - Examination Guidelines for Implementing the First Inventor To File Provisions of the Leahy-Smith...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-14

    ...for Implementing the First Inventor To File Provisions of the Leahy-Smith America...guidelines concerning the first inventor to file provisions of the Leahy-Smith America...invent'' system to a ``first inventor to file'' system, treats patents and...

  8. 78 FR 11023 - Changes To Implement the First Inventor To File Provisions of the Leahy-Smith America Invents Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-14

    ...for Implementing the First Inventor To File Provisions of the Leahy-Smith America...Changes To Implement the First Inventor To File Provisions of the Leahy-Smith America...invent'' system to a ``first inventor to file'' system; treats U.S. patents...

  9. 77 FR 448 - Changes To Implement the Preissuance Submissions by Third Parties Provision of the Leahy-Smith...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-05

    ...Parties Provision of the Leahy-Smith America Invents Act AGENCY: United States Patent and Trademark...ACTION: Notice of proposed rulemaking...the Leahy-Smith America Invents Act. B...for General Law of the United States Patent and...

  10. Inequality and political stability from Ancien Régime to revolution: The reception of Adam Smith's Theory of Moral Sentiments in France

    Microsoft Academic Search

    Ruth Scurr

    2009-01-01

    This article examines the excitement that Adam Smith's Theory of Moral Sentiments generated in France during the French Revolution, focusing particularly on the writings of political theorists, participants and commentators such as the abbé Sieyès, Pierre-Louis Rœderer, the Marquis de Condorcet and Sophie de Grouchy Condorcet, who were dismayed at their political opponents’ use of Rousseau, and looked to Smith

  11. Adrenal function in Smith-Lemli-Opitz Syndrome

    PubMed Central

    Bianconi, Simona E; Conley, Sandra K; Keil, Meg F; Sinaii, Ninet; Rother, Kristina I; Porter, Forbes D; Stratakis, Constantine A

    2012-01-01

    Smith-Lemli-Opitz syndrome (SLOS) is a multiple malformation syndrome due to mutations of the 7-dehydrocholesterol reductase gene (DHCR7), which leads to a deficiency of cholesterol synthesis and an accumulation of 7-dehydrocholesterol and related metabolites. The SLOS clinical spectrum ranges from multiple major malformations to a mild phenotype with dysmorphic features, intellectual disability and a specific behavioral presentation. Several cases of SLOS with adrenal insufficiency have been described. We performed ovine corticotropin (oCRH) testing in 35 SLOS patients and 16 age- and gender-matched controls. We reviewed prior ACTH stimulation tests of our SLOS patients (19 of 35 available) and reviewed ACTH stimulation tests from additional 10 other SLOS patients. Results from oCRH testing showed that patients with SLOS had significantly higher ACTH baseline values than healthy controls (24.8 ± 15.3 pg/mL vs. 17.8 ± 7.5 pg/mL, p=0.034). However, no statistically significant differences were noted for peak ACTH values (74.4 ± 35.0 pg/mL vs. 64.0 ± 24.9 pg/mL, p=0.303) and for baseline (14.2 ± 7.8 mcg/dL vs. 14.2 ± 6.3 mcg/dL, p=0.992) and peak cortisol values (28.2 ± 7.9 mcg/dL vs. 24.8 ± 8.1 mcg/dL, p=0.156). The area-under-the-curve (AUC) was not significantly different in SLOS patients compared to controls for both ACTH (250.1 ± 118.7 pg/mL vs. 195.3 ± 96.6 pg/mL, p=0.121) as well as cortisol secretion (83.1 ± 26.1 mcg/dL vs. 77.8 ± 25.9 mcg/dL, p=0.499). ACTH stimulation test was normal in 28 of 29 tests. The individual with the abnormal ACTH stimulation test had a normal oCRH test during the same evaluation. The slightly increased baseline ACTH level seen during oCRH testing may be due to compensated mild adrenocortical insufficiency. However, we were able to show that our cohort affected with SLOS had an adequate stress response and that in mild to moderate cases of SLOS stress steroid coverage should not be required. PMID:21990131

  12. Automatic flatness control strategy with a Smith predictor for steel strip rolling

    NASA Astrophysics Data System (ADS)

    Zhang, Ruicheng; Zheng, Xin

    2011-10-01

    The simplified transfer function diagram block for a automatic flatness control (AFC) system of strip steel rolling process was investigated. For the problem of automatic flatness control (AFC) in cold tandem mills this paper proposes control techniques based on Smith predictor to compensate for the numerous delays present in the mill. After a Smith predictor was used to the AFC system, the control laws were deduced for both proportional and integral regulators. Control algorithms are tested in simulation considering a tandem mill with four stands as a benchmark, and results are shown to demonstrate the performance of the proposed schemes.

  13. Design of a grating for studying Smith-Purcell radiation and electron acceleration

    SciTech Connect

    Fernow, R.C. (Brookhaven National Laboratory, Upton, NY 11973 (US))

    1989-10-15

    We describe work on the design fo a diffracton grating which we intend to use for studying the production of Smith-Purcell radiation and the acceleration of electrons. We have developed computer codes based on the solution of the appropriate Maxwell's equations. A specific grating profile is given which is feasible to construct and which supports enhanced surface accelerating modes. We examine the possibility of using the Smith-Purcell effect to make a beam position monitor. {copyright} 1989 American Institute of Physics

  14. Reduce the start current of Smith-Purcell backward wave oscillator by sidewall grating

    SciTech Connect

    Li, D.; Imasaki, K.; Gao, X.; Yang, Z.; Park, Gun-Sik [Institute for Laser Technology, 2-6 Yamada-oka, Suita, Osaka 565-0871 (Japan); Institute of High-Energy Electronics, University of Electronic Science and Technology of China, Chengdu 610054 (China); School of Physics and Astronomy, Seoul National University, Seoul 151-747 (Korea, Republic of)

    2007-11-26

    A sidewall grating for the Smith-Purcell device is proposed to enhance the coupling of the optical mode with the electron beam and, consequently, relax the stringent requirements to the electron beam. With the help of three-dimensional particle-in-cell simulations, it has been shown that, comparing with the general grating, the usage of a sidewall grating improves the growth rate and dramatically shortens the time for the device to reach saturation. It is also found that the sidewall grating holds the potential to reduce the start current for the operation of a Smith-Purcell backward wave oscillator.

  15. Design of a grating for studying Smith-Purcell radiation and electron acceleration

    SciTech Connect

    Fernow, R.C.

    1989-01-01

    We describe work on the design of a diffraction grating which we intend to use for studying the production of Smith-Purcell radiation and the acceleration of electrons. We have developed computer codes based on the solution of the appropriate Maxwell's equations. A specific grating profile is given which is feasible to construct and which supports enhanced surface accelerating modes. We examine the possibility of using the Smith-Purcell effect to make a beam position monitor. 13 refs., 10 figs., 2 tabs.

  16. Improve growth rate of Smith-Purcell free-electron laser by Bragg reflector

    SciTech Connect

    Li, D.; Imasaki, K. [Institute for Laser Technology, Suita, Osaka 565-0871 (Japan); Yang, Z. [Institute of High Energy Electronics, University of Electronic Science and Technology of China, Chengdu 610054 (China); Tsunawaki, Y. [Department of Electronics, Information and Communication Engineering, Osaka Sangyo University, Osaka 574-8530 (Japan); Asakawa, M. R. [Department of Pure and Applied Physics, Faculty of Engineering Science, Kansai University, Osaka 64-8680 (Japan); Hangyo, M. [Institute of Laser Engineering, Osaka University, Suita, Osaka 565-0871 (Japan); Miyamoto, S. [Laboratory of Advanced Science and Technology for Industry, University of Hyogo, Ako, Hyogo 678-1205 (Japan)

    2011-05-23

    Grating with Bragg reflectors for the Smith-Purcell free-electron laser is proposed to improve the reflection coefficient, resulting in enhancing the interaction of the surface wave with the electron beam and, consequently, relax the requirements to the electron beam. With the help of particle-in-cell simulations, it has been shown that the usage of Bragg reflectors may improve the growth rate, shorten the time for the device to reach saturation, and lower the start current for the operation of a Smith-Purcell free-electron laser.

  17. Adam Smith and Social Justice: the Ethical Basis of the Weath of Nations

    E-print Network

    Ossar, Jacob

    "Adam Smith and Social Justice: the Ethical Basis of the Wealth of Nations'' JACOB OSSÄR The University of Kansas /. Introduction Many in the West seem to regard the collapse of the so-called communist regimes in the Eastern Europe..., No. 2 126 AUSLEGUNG In this paper, I will examine the works of Adam Smith, one of the most influential exponents of modern capitalist economic theory.3 I will argue that his theory does rest and must rest on a number of claims that have far...

  18. Beyond Sweetgrass: The Life and Art of Jaune Quick-to-See Smith

    E-print Network

    Murphy, Joni Lisa

    2008-10-27

    of Smith?s body of work, and I suggest further directions her career may take. My research is framed by the following questions. 1) In dealing with art galleries, making art for profit, being interviewed, photographed, televised and written about, how do... as a mainstream artist? (2) American Indians traditionally loathe the written word, so how do they re-invent their self- image and work to meet the often-literary demands of critics, galleries, and museums? In his essay ?Contexts for Growth...

  19. Fort Smith, mother post of the southwest quartermaster supply and archeological patterning

    E-print Network

    Bento, Sylvia Deborah

    1988-01-01

    FORT SMITH~ MOTHER POST OF THE SOUTHWEST QUARTERMASTER SUPPLY AND ARCHEOLOG I CAL PATTERNING A Thesis by SYLVIA DEBORAH BENTO Submitted to the Graduate College of Texas ASM University in partial fulf i 1 lment of the requirements... for the degree of MASTER OF ARTS May 1988 Major Subject: Anthropo logy FORT SMITH, MOTHER POST OF TIRE SOUTHHEST QUARTERMASTER SUPPLY At4D ARCHEOLOG ICAL PATTER) iING A Thesis by SYLVIA DEBORAH BENTO Approved as to style and content by: David L. Carlson...

  20. A la recherche du spectateur impartial perdu A propos d' Adam Smith and the economy of the passions de J-H Keppler, Routledge,

    E-print Network

    Paris-Sud XI, Université de

    A la recherche du spectateur impartial perdu A propos d'« Adam Smith and the economy of the passions » de J-H Keppler, Routledge, 2010 Benoît Walraevens1 "Unlike old soldiers, old Adam Smith Problems'Economie des passions selon Adam Smith » paru deux ans plus tôt aux éditions Kimé. Au sein d'une littérature

  1. Andr Lapidus Le profit ou la domination : La figure de l'esclave dans l'conomie d'Adam Smith 1 Le profit ou la domination

    E-print Network

    Boyer, Edmond

    André Lapidus ­ Le profit ou la domination : La figure de l'esclave dans l'économie d'Adam Smith 1 Le profit ou la domination : La figure de l'esclave dans l'économie d'Adam Smith André Lapidus l'esclavage au moyen des théories du droit naturel. 2 Les références aux oeuvres d'Adam Smith (voir

  2. A Parallel Java Grande Benchmark Suite L. A. Smith and J. M. Bull

    E-print Network

    Bull, Mark

    A Parallel Java Grande Benchmark Suite L. A. Smith and J. M. Bull EPCC, The King's Buildings Republic. email: xobdrzal@fi.muni.cz Abstract Increasing interest is being shown in the use of Java for large scale or Grande applications. This new use of Java places specific demands on the Java execution

  3. 40 CFR 81.63 - Metropolitan Fort Smith Interstate Air Quality Control Region.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    40 ? Protection of Environment ? 18 ? 2014-07-01 ? 2014-07-01 ? false ? Metropolitan Fort Smith Interstate Air Quality Control Region. ? 81.63 ? Section 81.63 ? Protection of Environment ? ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ? AIR PROGRAMS (CONTINUED) ? DESIGNATION OF AREAS FOR AIR...

  4. 78 FR 32250 - CDM Smith and Dynamac Corp; Transfer of Data

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-29

    This notice announces that pesticide related information submitted to EPA's Office of Pesticide Programs pursuant to the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) and the Federal Food, Drug, and Cosmetic Act (FFDCA), including information that may have been claimed as Confidential Business Information (CBI) by the submitter, will be transferred to CDM Smith and its......

  5. 40 CFR 81.63 - Metropolitan Fort Smith Interstate Air Quality Control Region.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    40 ? Protection of Environment ? 18 ? 2013-07-01 ? 2013-07-01 ? false ? Metropolitan Fort Smith Interstate Air Quality Control Region. ? 81.63 ? Section 81.63 ? Protection of Environment ? ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ? AIR PROGRAMS (CONTINUED) ? DESIGNATION OF AREAS FOR AIR...

  6. Discovery and antitumor activities of constituents from Cyrtomium fortumei (J.) Smith rhizomes

    PubMed Central

    2013-01-01

    Background Cyrtomium fortumei (J.) Smith is an important Chinese herbal medicine because of its biological functions. However, systematic and comprehensive studies on the phytochemicals from Cyrtomium fortumei (J.) Smith and their bioactivity are limited. Results Using the bioassay-guided technique, the ethyl acetate and n-BuOH extracts of the rhizomes of Cyrtomium fortumei (J.) Smith were shown to exhibit good antitumor activities, consequently leading to the isolation of 23 compounds. All compounds were isolated from the plant for the first time. The inhibitory activities of these compounds were investigated on tumor cells MGC-803, PC3, and A375 in vitro by MTT (thiazolyl blue tetrazolium bromide) assay, and the results showed that pimpinellin (3) had potent cytotoxic activities against the three cell lines, with the IC50 values of 14.4?±?0.3??M, 20.4?±?0.5??M, and 29.2?±?0.6??M, respectively. The mechanism of the antitumor action indicated that pimpinellin inhibited the growth of MGC-803 cells via the induction of tumor cell apoptosis, with apoptosis ratio of 27.44% after 72?h of treatment at 20??M. Conclusions This study suggests that most of the compounds from the roots of Cyrtomium fortumei (J.) Smith could inhibit the growth of human carcinoma cells. Moreover, pimpinellin inhibited the growth of tumor cells via the induction of tumor cell apoptosis. PMID:23379693

  7. Fiber Fox--Smith resonators: application to single-longitudinal-mode operation of fiber lasers

    SciTech Connect

    Barnsley, P.; Urquhart, P.; Millar, C.; Brierley, M.

    1988-08-01

    An optical-fiber Fox--Smith resonator was demonstrated for the first time to our knowledge. It was applied to obtain single-longitudinal-mode operation from an erbium-doped fiber laser. Both the passive performance and the active performance of the device are studied in detail. Good agreement is found between theoretical and experimental results.

  8. 77 FR 64411 - Safety Zone; Cooper T. Smith Fireworks Event; Mobile River; Mobile, AL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-22

    The Coast Guard is establishing a temporary safety zone for a portion of the Mobile River, Mobile, AL in the vicinity of Cooper Riverside Park. This action is necessary for the protection of persons and vessels on navigable waters during the Cooper T. Smith Fireworks Event. Entry into, transiting or anchoring in this zone is prohibited to all vessels, mariners, and persons unless specifically......

  9. The Stiller-Smith, cross-slider engine: A balanced engine concept

    SciTech Connect

    Smith, J.E.; Nesbit, S.; Churchill, R.

    1987-01-01

    The Stiller-Smith Engine employs a double cross-slider that has several advantageous dynamic characteristics. These characteristics are described and developed analytically. This paper also develops and presents the force equations that describe the two-dimensional model of this engine. The necessary requirements to produce a balanced engine are derived and evaluated analytically.

  10. Inhibitory effects of Cyrtomium fortunei J. Smith root extract on melanogenesis

    PubMed Central

    Choi, Sang Yoon

    2013-01-01

    Background: Recently, a great deal of attention has been directed toward the use of crude extracts from natural products for cosmetic applications. Thus, we performed a series of experiments to investigate skin depigmenting properties of a crude extract that was derived from a traditional Korean medicinal plant. Materials and Methods: In this study, the depigmentational potency of Cyrtomium fortunei J. Smith was investigated. The inhibitory effects of the root of Cyrtomium fortunei J. Smith extract on melanin production were evaluated by assessing its tyrosinase inhibitory effects, melanin production-inhibitory properties in melan-a cells and depigmenting ability in brown guinea pig skin. Results: The methanolic extract of the root of Cyrtomium fortunei J. Smith appeared to inhibit tyrosinase activity and melanin production in melan-a cells. In addition, this extract exhibited depigmenting ability on Ultra violet-induced hyper pigmentation in brown guinea pig skin. Conclusion: These results suggested that root of Cyrtomium fortunei J. Smith might prove useful in treating skin hyperpigmentation associated with excess sun-exposure. PMID:23930006

  11. 77 FR 50155 - Neal Smith National Wildlife Refuge, Jasper County, IA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-20

    We, the U.S. Fish and Wildlife Service (Service), announce the availability of a draft comprehensive conservation plan (CCP) and environmental assessment (EA) for Neal Smith National Wildlife Refuge (Refuge, NWR) for public review and comment. In this draft CCP/EA we describe how we propose to manage the refuge for the next 15...

  12. Smith-Purcell frequency multiplier with synchronization of radiation from a wide electron beam

    SciTech Connect

    Bratman, V. L.; Fedotov, A. E.; Makhalov, P. B. [Institute of Applied Physics, Russian Academy of Sciences, Nizhny Novgorod (Russian Federation); Rusin, F. S. [Federal State Unitary Enterprise 'VNIIFTRI', Mendeleevo, Moscow region (Russian Federation)

    2009-02-09

    An orotronlike feedback can provide a significant increase in the selectivity and power of frequency-multiplied Smith-Purcell radiation of the electron bunches formed in the course of self-excitation of a grating surface eigenmode. This method looks promising for efficient terahertz generation from both weakly and mildly relativistic electron beams.

  13. 40 CFR 81.63 - Metropolitan Fort Smith Interstate Air Quality Control Region.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    40 ? Protection of Environment ? 17 ? 2011-07-01 ? 2011-07-01 ? false ? Metropolitan Fort Smith Interstate Air Quality Control Region. ? 81.63 ? Section 81.63 ? Protection of Environment ? ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ? AIR PROGRAMS (CONTINUED) ? DESIGNATION OF AREAS FOR AIR...

  14. 75 FR 37462 - Official Trail Marker for the Captain John Smith Chesapeake National Historic Trail

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-29

    This notice issues the official trail marker insignias of the Captain John Smith Chesapeake National Historic Trail. The insignia for this trail was completed in August 2008. The National Park Service has officially used an earlier version of this insignia since the trail was designated in 2006. It has been slightly redesigned since then so that lettering and framing match other National Trail......

  15. 78 FR 16286 - Neal Smith National Wildlife Refuge, Jasper County, IA; Final Comprehensive Conservation Plan and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-14

    We, the U.S. Fish and Wildlife Service (Service), announce the availability of a final comprehensive conservation plan (CCP) and finding of no significant impact (FONSI) for the Environmental Assessment (EA) for Neal Smith National Wildlife Refuge (Refuge, NWR). In this final CCP, we describe how we intend to manage the refuge for the next 15...

  16. 40 CFR 81.63 - Metropolitan Fort Smith Interstate Air Quality Control Region.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    40 ? Protection of Environment ? 17 ? 2010-07-01 ? 2010-07-01 ? false ? Metropolitan Fort Smith Interstate Air Quality Control Region. ? 81.63 ? Section 81.63 ? Protection of Environment ? ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ? AIR PROGRAMS (CONTINUED) ? DESIGNATION OF AREAS FOR AIR...

  17. 40 CFR 81.63 - Metropolitan Fort Smith Interstate Air Quality Control Region.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    40 ? Protection of Environment ? 18 ? 2012-07-01 ? 2012-07-01 ? false ? Metropolitan Fort Smith Interstate Air Quality Control Region. ? 81.63 ? Section 81.63 ? Protection of Environment ? ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ? AIR PROGRAMS (CONTINUED) ? DESIGNATION OF AREAS FOR AIR...

  18. I Experientially Remember, Therefore I Exist? A Reply to R. D. Smith.

    ERIC Educational Resources Information Center

    Lloyd, D. I.

    1983-01-01

    Smith (Journal of Philosophy of Education; v17 n1 p85-96) must clarify the importance of memory to identity by explaining experiential memory's unique cognitive state, why it is not as fallible as other forms of memory, and why forgetting affective experiences may not be as important as remembering them. (SR)

  19. DEVLOPMENT OF A LOW EMITTANCE DC GUN FOR SMITH-PURCELL BWO FEL

    Microsoft Academic Search

    K. Kasamsook; K. Akiyama; K. Nanbu; M. Kawai; F. Hinode; T. Muto; T. Tanaka; M. Yasuda

    An electron DC gun capable for producing very low emittance beam is now under evaluation of beam qualities at Laboratory of Nuclear Science, Tohoku University. The DC gun employs a high voltage of 50 kV to extract electrons, which is suitable to drive Smith-Purcell backward wave oscillator free electron laser (BWO FEL) (1). From a result of numerical simulation using

  20. Analysis of the Sensory Profile in Children with Smith-Magenis Syndrome

    ERIC Educational Resources Information Center

    Hildenbrand, Hanna L.; Smith, Ann C. M.

    2012-01-01

    This study systematically assessed sensory processing in 34 children, aged 3-14 years, with Smith-Magenis syndrome (SMS) using the Sensory Profile Caregiver Questionnaire. Scores for the SMS cohort were significantly different from scores of the national sample of children with and without disabilities in all Sensory Profile categories and…

  1. A Case Study of Early Development in Smith-Magenis Syndrome

    ERIC Educational Resources Information Center

    Fidler, Deborah J.; Philofsky, Amy D.; Hepburn, Susan L.

    2006-01-01

    The aim of this article is to provide an in-depth description of early development in a young child with Smith-Magenis syndrome (SMS). SMS is a multisystem, neurodevelopmental genetic disorder associated with mental retardation that predisposes individuals to a distinct pattern of maladaptive behaviors and other neuropsychological impairments.…

  2. Accuracy and resolution of shuttle radar topography mission data Bridget Smith and David Sandwell

    E-print Network

    Sandwell, David T.

    ascending and descending C-band swaths from the Shuttle interferometer were processed into a digitalAccuracy and resolution of shuttle radar topography mission data Bridget Smith and David Sandwell provided by the Shuttle Radar Topography Mission (SRTM) through spectral comparisons with the National

  3. Ideology and Reform in Teacher Education in England: Some Reflections on Cochran-Smith and Fries.

    ERIC Educational Resources Information Center

    Furlong, John

    2002-01-01

    Presents an international perspective on Cochran-Smith and Fries' recent analysis of the ways that two competing ideologies (deregulation and professionalization) are being employed in the United States to support teacher education reform, noting important differences between the United States and England in how these ideologies have been advanced…

  4. Ibas: A Tool for Finding Minimal Unary NFAs Daniel Cazalis and Geoffrey Smith

    E-print Network

    Smith, Geoffrey

    Ibas: A Tool for Finding Minimal Unary NFAs Daniel Cazalis and Geoffrey Smith School of Computing, we describe Ibas, a tool for finding minimal unary NFAs. The input to Ibas is a bit-vector describing-state NFAs, and would take many trillions of year for 10-state NFAs. Ibas, in contrast, can often find

  5. User Interface for the Control of the Gemini Telescopes S. S. Smith and K. Gillies

    E-print Network

    to follow the ESO Graphical User Interface Common Conventions.2 Although several graphical user interfaceUser Interface for the Control of the Gemini Telescopes S. S. Smith and K. Gillies Gemini 8-M operator user interface developed for the Gemini 8-m Telescopes is presented. Topics include the use

  6. User Interface for the Control of the Gemini Telescopes S. S. Smith and K. Gillies

    E-print Network

    are being built using Tcl/Tk 1 and are implemented to follow the ESO Graphical User Interface Common Conventions. 2 Although several graphical user interface (GUI) builders were investigated, a decisionUser Interface for the Control of the Gemini Telescopes S. S. Smith and K. Gillies Gemini 8­M

  7. CONTRIBUTIONS TO THE BIOLOGY OF THE ROYAL RED SHRIMP, Hymenopenaeus robustus SMITH'

    E-print Network

    CONTRIBUTIONS TO THE BIOLOGY OF THE ROYAL RED SHRIMP, Hymenopenaeus robustus SMITH' WILLIAM W. ANDERSON' AND MILTON J. LINDNER" ABSTRACf The royal red shrimp, HymenopenaeuB robuBtus, has been located collections of the M/V Theodore N. Gill. Juveniles under 50 mm total length were not caught. Size of shrimp

  8. LATTICE POLYMER AUTOMATA Steen RASMUSSEN a;b and Joshua R. SMITH b;c

    E-print Network

    Herr, Hugh

    LATTICE POLYMER AUTOMATA Steen RASMUSSEN a;b and Joshua R. SMITH b;c a TSA­DO/SA MS M997 and CNLS MS B258 Los Alamos National Laboratory Los Alamos, NM 87545 U.S.A. b Santa Fe Institute 1660 Old, the Lattice Polymer Automaton [LPA]. In the LPA all interactions, including electromagnetic forces

  9. Stress in Families of Young Children with Down Syndrome, Williams Syndrome, and Smith-Magenis Syndrome.

    ERIC Educational Resources Information Center

    Fidler, Deborah J.; Hodapp, Robert M.; Dykens, Elizabeth M.

    2000-01-01

    Compared stress levels in families of children with Down syndrome (DS), Williams syndrome (WS), or Smith-Magenis syndrome (SMS). Found that DS families experienced less Pessimism than others and less Parent and Family Problems than SMS families. Strongest predictors of Parent and Family Problems were maladaptive behavior in SMS, younger age in DS,…

  10. Biomarkers of Leukemia Risk: Benzene Martyn T. Smith and Luoping Zhang

    E-print Network

    California at Berkeley, University of

    Biomarkers of Leukemia Risk: Benzene as a Model Martyn T. Smith and Luoping Zhang Division relatively rare, leukemias place a considerable financial burden on society and cause psychologic trauma to many families. Leukemia is the most common cancer in children. The causes of leukemia in adults

  11. IMPROVED CHEN-SMITH IMAGE CODER * Eduardo M. Rubino, Henrique S. Malvar

    E-print Network

    de Queiroz, Ricardo L.

    and the re- placement of the discrete cosine transform (DCT) by the lapped orthogonal transform (LOTIMPROVED CHEN-SMITH IMAGE CODER * Eduardo M. Rubino, Henrique S. Malvar Dept. de Engenharia El An image compression system based on transform coding and zonal sampling is presented. It is based

  12. Back to Beginnings: Credentialism, Productivity, and Adam Smith's Division of Labour.

    ERIC Educational Resources Information Center

    Davis, Denis J.

    1981-01-01

    The foundation of factional pressures for upgrading educational credentials in the labor market is examined through a review of human capital and screening theories. The writings of Adam Smith are referenced to show that the claims of the beneficial effects of educational upgrading have been questioned for 200 years. (Author/MLW)

  13. Comparing Adam Smith's Wealth of Nations to James Madison's Federalist #10.

    ERIC Educational Resources Information Center

    Mundell, Jean

    1987-01-01

    Presents a lesson which calls upon students to compare Adam Smith's WEALTH OF NATIONS to James Madison's FEDERALIST #10 to see how the ancient concept of individual rights and liberties was used to describe both economic and governmental systems. Presents questions to provide the basis for comparison. (GEA)

  14. Adam Smith, Adam Ferguson and Karl Marx on the Division of Labour

    Microsoft Academic Search

    Lisa Hill

    2007-01-01

    Adam Smith (1723—90) and Adam Ferguson (1723—1816) shared a keen interest in the social, economic and individual effects of specialization. Though this mutual interest led to a protracted priority dispute between them, nevertheless their approaches differed significantly. Ferguson was generally more negative in his attitude and was also less interested in the economic effects of specialization, focusing instead on its

  15. UWAgents: A Mobile Agent System Optimized for Grid Computing Munehiro Fukuda Duncan Smith

    E-print Network

    Fukuda, Munehiro

    , consider grid computing as a potential application for mobile agents. Grid computing applications benefitUWAgents: A Mobile Agent System Optimized for Grid Computing Munehiro Fukuda Duncan Smith Computing-based mobile agent system opti- mized for implementing grid computing infrastructure. Un- like most mobile

  16. ON THE SUITABILITY OF LONGITUDINAL PROFILE MEASUREMENTS USING COHERENT SMITH-PURCELL RADIATION

    E-print Network

    Boyer, Edmond

    monitors using Smith-Purcell radiation for such proton beams. INTRODUCTION Handling high current proton FOR HIGH CURRENT PROTON BEAMS J. Barros, N. Delerue, M. Vieille-Grosjean, LAL, Orsay, France I. Dolenc energy sections, it is highly advis- able to use non interceptive devices to avoid radiations or damage

  17. UTILIZING GOOGLE EARTH AS A GIS PLATFORM FOR WEATHER APPLICATIONS Travis M. Smith1,2

    E-print Network

    Smith, Travis

    UTILIZING GOOGLE EARTH AS A GIS PLATFORM FOR WEATHER APPLICATIONS Travis M. Smith1,2 and Valliappa Lakshmanan1,2 1 U. of Oklahoma/CIMMS; 2 NOAA/NSSL 1. Introduction Google Earth (formerly known as Keyhole; http://earth.google.com) is a free-for- personal-use application that streams high- resolution static

  18. INFRARED LIGHT CURVES OF MIRA VARIABLE STARS FROM COBE DIRBE DATA Beverly J. Smith

    E-print Network

    Luttermoser, Donald G.

    INFRARED LIGHT CURVES OF MIRA VARIABLE STARS FROM COBE DIRBE DATA Beverly J. Smith Department have used the COBE DIRBE database to derive near- and mid-infrared light curves for a well-defined sample of 38 infrared-bright Mira variable stars and compared with optical data from the AAVSO

  19. Analyzing (Social Media) Networks with NodeXL Marc A. Smith1

    E-print Network

    Golbeck, Jennifer

    Analyzing (Social Media) Networks with NodeXL Marc A. Smith1 , Ben Shneiderman2 , Natasa Milic with a social media data sample drawn from an enterprise intranet social network. A sequence of Node relevant differences in the patterns of interconnection among employee participants in the social media

  20. Travel Time Models MacGregor Smith & Cruz State Dependent Travel Time Models, Properties,

    E-print Network

    Cruz, Frederico

    Travel Time Models MacGregor Smith & Cruz State Dependent Travel Time Models, Properties, & Kerner networks is an accurate estimate of travel time on arterial links, highway, and freeways way to esti- mate travel times for this complex task. Realistically, however, travel time is a random

  1. The Perceived Significance of Suicide in Male vs. Female Breadwinners Steven M. Smith 1

    E-print Network

    Zhou, Yaoqi

    The Perceived Significance of Suicide in Male vs. Female Breadwinners Steven M. Smith 1 1 significance of male and female suicide as viewed by a third party member/member of the public. Specifically it investigates if differences exist in perceived significance of a male or female suicide when the suicide

  2. Pathways: Possibilities for Reform and Social Justi ce A Reaction Paper to Smith

    Microsoft Academic Search

    Robyn Zevenbergen

    From Smith's paper, I understand him to be raising a number of points. First, that the pathways that students take through mathematics should be meaningful and lead to productive lives in the new labour markets. He sug gests that the old forms of mathematics teaching are not as effective as they s hould be and that there is a need

  3. Ideology and Reform in Teacher Education in England: Some Reflections on Cochran-Smith and Fries

    Microsoft Academic Search

    John Furlong

    2002-01-01

    This article presents an international perspective on Cochran-Smith and Fries’ (2001) recent analysis of the ways in which two competing ideologies are currently being employed in the United States in support of teacher education reform. In England over the last 15 years, teacher education has been fundamentally reformed and the arguments of both the “deregulators” and the “professionalizers” have been

  4. Celebrating the Past, Ensuring the Future--A Profile of President Glenn Smith

    ERIC Educational Resources Information Center

    Blumenthal, Anita

    2013-01-01

    "I had no idea how to convince someone to hire me," recalls APPA President, Glen Smith. His first interview was with Bryn Mawr College, a small, prestigious private college with Quaker roots, located 12 miles west of Philadelphia. That was in 1997, after 24 years in the Naval Civil Engineer Corps, and he still remembers a certain…

  5. ESTIMATION OF SURPLUS BIOMASS OF CLUPEIDS IN SMITH MOUNTAIN LAKE, VIRGINIA

    EPA Science Inventory

    Mean annual estimates of surplus biomass of alewife Alosa pseudoharengus and gizzard shad Dorosoma cepedianum in Smith Mountain Lake, Virginia, were calculated using data on the biomass, growth, and mortality of each clupeid species. Surplus biomass, defined as production over a...

  6. Another Look at the Glass and Smith Study on Class Size

    ERIC Educational Resources Information Center

    Phelps, James L.

    2011-01-01

    One of the most influential studies affecting educational policy is Glass and Smith's 1978 study, "Meta-Analysis of Research on the Relationship of Class-Size and Achievement." Since its publication, educational policymakers have referenced it frequently as the justification for reducing class size. While teachers and the public had long believed…

  7. LIFE HISTORY MONITORING OF SALMONIDS IN THE WEST FORK SMITH RIVER, UMPQUA BASIN, OREGON

    EPA Science Inventory

    As a life-cycle monitoring basin for the Oregon Salmon Plan, the Oregon Department of Fish and Wildlife has estimated adult returns, distribution and smolt outmigration of coho, chinook and winter steelhead in the West Fork Smith River since 1998. In 2001/2002, the Environmenta...

  8. EFFECTS OF SOME TRACE ELEMENTS ON THE BLOOD OF KUWAIT MULLETS 'LIZA MACROLEPS' (SMITH)

    EPA Science Inventory

    Haemopathological changes attributed to heavy metal poisoning observed in blood smears of Liza macrolepis (Smith) taken after exposures of 96 h to graded doses (mg/l) of copper (0.11-1.80), lead (1.15-18.36), and mercury (0.04-0.59), in a flow-through marine bioassay system. In g...

  9. Development of Novel Data Compression Technique for Accelerate DNA Sequence Alignment Based on Smith

    Microsoft Academic Search

    S. A. M. Al Junid; M. A. Haron; Z. Abd Majid; A. K. Halim; F. N. Osman; H. Hashim

    2009-01-01

    This paper presents the development of high performance accelerating technique for DNA sequences alignment. The scope of the paper focuses on speed optimization and memory reduction of the existing technique on initialization module. The novel development of the optimization using data compression technique for accelerates the Smith-Waterman (SW) algorithm has been revealed through this paper. This technique has been implemented

  10. Improved Routing Wasps for Distributed Factory Control Vincent A. Cicirello and Stephen F. Smith

    E-print Network

    Cicirello, Vincent A.

    Improved Routing Wasps for Distributed Factory Control Vincent A. Cicirello and Stephen F. Smith approach to coordinating factory routing and scheduling based on a computational model of wasp behavior. The natural multi-agent sys- tem of the wasp colony is highly effective in self- organizing the allocation

  11. Modeling Building Thermal Response to HVAC Virginia Smith, Tamim Sookoor, and Kamin Whitehouse

    E-print Network

    Whitehouse, Kamin

    Modeling Building Thermal Response to HVAC Zoning Virginia Smith, Tamim Sookoor, and Kamin;2 Modeling Building Thermal Response to HVAC Zoning the HVAC system to be focused on maintaining occupied rooms at a comfortable temperature without wasting any energy conditioning unoccupied rooms. Many homes

  12. Multi-product pricing for electric Shmuel S. Oren, Stephen A. Smith and Robert B. Wilson

    E-print Network

    Oren, Shmuel S.

    Multi-product pricing for electric power Shmuel S. Oren, Stephen A. Smith and Robert B. Wilson This paper describes methods for determining the prices for a discrete set of interrelated products oflered by a single supplier. Each product has a fixed marginal rate per unit, the demand for each product depends

  13. A Sound Polymorphic Type System for a Dialect of C Geoffrey Smith

    E-print Network

    Smith, Geoffrey

    A Sound Polymorphic Type System for a Dialect of C Geoffrey Smith School of Computer Science into a dialect of C, which we call Polymorphic C. It has the same pointer operations as C, including the address of Computer Programming, vol. 32, nos. 2­3, 1998. This material is based upon work supported by the National

  14. RapidSmith: Do-It-Yourself CAD Tools for Xilinx FPGAs

    Microsoft Academic Search

    Christopher Lavin; Marc Padilla; Jaren Lamprecht; Philip Lundrigan; Brent Nelson; Brad Hutchings

    2011-01-01

    Creating CAD tools for commercial FPGAs is a dif- ficult task. Closed proprietary device databases and unsupported interfaces are largely to blame for the lack of CAD research found on commercial architectures versus hypothetical architectures. This paper formally introduces RapidSmith, a new set of tools and APIs that enable CAD tool creation for Xilinx FPGAs. Based on the Xilinx Design

  15. Hidden species complexes within distinctive taxa: the case of Epanthidium bicoloratum (Smith) (Hymenoptera: Megachilidae)

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Epanthidium bicoloratum (Smith) differs from all other Neotropical Anthidiini in the distinctive tegula, which is narrowed posteriorly forming a slender wedge. Examination of material standing under this name revealed that it represents a species complex that includes three new cryptic species, E. ...

  16. SOLUBLE GROUPS WITH A FINITE REWRITING SYSTEM J.R.J. Groves & G.C. Smith

    E-print Network

    Smith, Geoff

    SOLUBLE GROUPS WITH A FINITE REWRITING SYSTEM J.R.J. Groves & G.C. Smith Abstract. We describe a class of soluble groups with a finite complete re* *writing system which includes all the soluble groups known to have such a system.* *It is an open question

  17. Has "Wisconsin v. Yoder" Been Reversed? Analysis of "Employment Division v. Smith."

    ERIC Educational Resources Information Center

    Mawdsley, Ralph D.

    1990-01-01

    Compares the Supreme Court ruling in "Employment Division, Department of Human Resources of Oregon v. Smith," involving the denial of unemployment compensation to two employees discharged because they ingested peyote, to "Wisconsin v. Yoder," mandating exemption to Amish parents of the state's uniformly applied compulsory attendance statute. (MLF)

  18. CHARACTERIZATION OF AMPHIPLOID HYBRIDS BETWEEN PSEUDOROEGNERIA SPICATA (PURSH.) A. LOVE AND ELYMUS LANCEOLATUS (SCRIBNER & SMITH) GOULD

    Technology Transfer Automated Retrieval System (TEKTRAN)

    An amphiploid derivative from hybrids between bluebunch wheatgrass (2n=2x=14) [Pseudoroegneria spicata (Pursh) A. Love] and thickspike wheatgrass (2n=4x=28) [Elymus lanceolatus (Scribner and Smith) (Gould] was developed to compare cytological, morphological, anatomical, and seed charateristics betwe...

  19. Synthesis of a Parallel Smith-Waterman Sequence Alignment Kernel into FPGA Hardware

    E-print Network

    Greaves, David J.

    the issue of making FPGA- based co-processors accessible to systems biologists who do not have an extensive to exploit FPGA-based co-processors to compute operations like DNA sequence matching without a requirementSynthesis of a Parallel Smith-Waterman Sequence Alignment Kernel into FPGA Hardware David Greaves

  20. 26. The StillwellBierce and SmithVaile Company, Dayton, Ohio, 13 April ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    26. The Stillwell-Bierce and Smith-Vaile Company, Dayton, Ohio, 13 April 1904 ELEVATION AND CUTAWAY DRAWINGS OF A TURBINE-GENERATOR UNIT IDENTICAL TO UNITS 4 AND 5 - Washington Water Power Company Monroe Street Plant, Units 4 & 5, South Bank Spokane River, below Monroe Street Bridge, Spokane, Spokane County, WA