Sample records for global daily irradiation

  1. Parameterization of daily solar global ultraviolet irradiation.

    PubMed

    Feister, U; Jäkel, E; Gericke, K

    2002-09-01

    Daily values of solar global ultraviolet (UV) B and UVA irradiation as well as erythemal irradiation have been parameterized to be estimated from pyranometer measurements of daily global and diffuse irradiation as well as from atmospheric column ozone. Data recorded at the Meteorological Observatory Potsdam (52 degrees N, 107 m asl) in Germany over the time period 1997-2000 have been used to derive sets of regression coefficients. The validation of the method against independent data sets of measured UV irradiation shows that the parameterization provides a gain of information for UVB, UVA and erythemal irradiation referring to their averages. A comparison between parameterized daily UV irradiation and independent values of UV irradiation measured at a mountain station in southern Germany (Meteorological Observatory Hohenpeissenberg at 48 degrees N, 977 m asl) indicates that the parameterization also holds even under completely different climatic conditions. On a long-term average (1953-2000), parameterized annual UV irradiation values are 15% and 21% higher for UVA and UVB, respectively, at Hohenpeissenberg than they are at Potsdam. Daily global and diffuse irradiation measured at 28 weather stations of the Deutscher Wetterdienst German Radiation Network and grid values of column ozone from the EPTOMS satellite experiment served as inputs to calculate the estimates of the spatial distribution of daily and annual values of UV irradiation across Germany. Using daily values of global and diffuse irradiation recorded at Potsdam since 1937 as well as atmospheric column ozone measured since 1964 at the same site, estimates of daily and annual UV irradiation have been derived for this site over the period from 1937 through 2000, which include the effects of changes in cloudiness, in aerosols and, at least for the period of ozone measurements from 1964 to 2000, in atmospheric ozone. It is shown that the extremely low ozone values observed mainly after the eruption of Mt

  2. The frequency distribution of daily global irradiation at Kumasi

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Akuffo, F.O.; Brew-Hammond, A.

    1993-02-01

    Cumulative frequency distribution curves (CDC) for daily global irradiation on the horizontal produced by Liu and Jordan in 1963 have until recently been considered to have universal validity. Results obtained by Saunier et al. in 1987 and Ideriah and Suleman in 1989 for two tropical locations, Ibadan in Nigeria and Bangkok in Thailand, respectively, have thrown into question the universal validity of the Liu and Jordan generalized CDC. Saunier et al., in particular, showed that their results disagreed with the generalized CDC mainly because of differences in the values of the maximum clearness index (Kmax), as well as the underlyingmore » probability density functions. Consequently, they proposed two expressions for determining Kmax and probability densities in tropical locations. This paper presents the results of statistical analysis of daily global irradiation for Kumasi, Ghana, also a tropical location. The results show that the expressions of Saunier et al. provide a better description of the observations than the generalized CDC and, in particular, the empirical equation for Kmax may be valid for Kumasi. Furthermore, the results show that the values of the minimum clearness index (Kmin) for Kumasi are much higher than the generally accepted value of 0.05 for overcast sky conditions. A comparison of the results for Kumasi and Ibadan shows that there is satisfactory agreement when the values of Kmax and Kmin are comparable; in cases where there are discrepancies in the Kmax and Kmin values, the CDC also disagree. 13 refs., 3 figs., 5 tabs.« less

  3. Reconstruction of daily solar UV irradiation from 1893 to 2002 in Potsdam, Germany

    NASA Astrophysics Data System (ADS)

    Junk, Jürgen; Feister, Uwe; Helbig, Alfred

    2007-08-01

    Long-term records of solar UV radiation reaching the Earth’s surface are scarce. Radiative transfer calculations and statistical models are two options used to reconstruct decadal changes in solar UV radiation from long-term records of measured atmospheric parameters that contain information on the effect of clouds, atmospheric aerosols and ground albedo on UV radiation. Based on earlier studies, where the long-term variation of daily solar UV irradiation was derived from measured global and diffuse irradiation as well as atmospheric ozone by a non-linear regression method [Feister et al. (2002) Photochem Photobiol 76:281 293], we present another approach for the reconstruction of time series of solar UV radiation. An artificial neural network (ANN) was trained with measurements of solar UV irradiation taken at the Meteorological Observatory in Potsdam, Germany, as well as measured parameters with long-term records such as global and diffuse radiation, sunshine duration, horizontal visibility and column ozone. This study is focussed on the reconstruction of daily broad-band UV-B (280 315 nm), UV-A (315 400 nm) and erythemal UV irradiation (ER). Due to the rapid changes in cloudiness at mid-latitude sites, solar UV irradiance exhibits appreciable short-term variability. One of the main advantages of the statistical method is that it uses doses of highly variable input parameters calculated from individual spot measurements taken at short time intervals, which thus do represent the short-term variability of solar irradiance.

  4. Forecasting Plant Productivity and Health Using Diffuse-to-Global Irradiance Ratios Extracted from the OMI Aerosol Product

    NASA Technical Reports Server (NTRS)

    Knowlton, Kelly; Andrews, Jane C.; Ryan, Robert E.

    2007-01-01

    Atmospheric aerosols are a major contributor to diffuse irradiance. This Candidate Solution suggests using the OMI (Ozone Monitoring Instrument) aerosol product as input into a radiative transfer model, which would calculate the ratio of diffuse to global irradiance at the Earth s surface. This ratio can significantly influence the rate of photosynthesis in plants; increasing the ratio of diffuse to global irradiance can accelerate photosynthesis, resulting in greater plant productivity. Accurate values of this ratio could be useful in predicting crop productivity, thereby improving forecasts of regional food resources. However, disagreements exist between diffuse-to-global irradiance values measured by different satellites and ground sensors. OMI, with its unique combination of spectral bands, high resolution, and daily global coverage, may be able to provide more accurate aerosol measurements than other comparable sensors.

  5. Classification of daily solar irradiation by fractional analysis of 10-min-means of solar irradiance

    NASA Astrophysics Data System (ADS)

    Harrouni, S.; Guessoum, A.; Maafi, A.

    2005-02-01

    This paper deals with fractal analysis of daily solar irradiances measured with a time step of 10 minutes at Golden and Boulder located in Colorado. The aim is to estimate the fractal dimensions in order to perform classification of daily solar irradiances. The estimated fractal dimension hat{D} and the clearness index KT are used as classification criteria. The results show that these criteria lead to three classes: clear sky, partially covered sky and overcast sky. The results also show that the evaluation of the fractal dimension of the irradiance signal based on a data set with 10 minutes time step is possible.

  6. Global Mapping of Underwater UV Irradiances and DNA-Weighted Exposures using TOMS and SeaWiFS Data Products

    NASA Technical Reports Server (NTRS)

    Vasilkov, Alexander; Krotkov, Nickolay; Herman, Jay; McClain, Charles; Arrigo, Kevin; Robinson, Wayne

    1999-01-01

    The global stratospheric ozone-layer depletion results In an increase in biologically harmful ultraviolet (UV) radiation reaching the surface and penetrating to ecologically significant depths in natural waters. Such an increase can be estimated on a global scale by combining satellite estimates of UV irradiance at the ocean surface from the Total Ozone Mapping Spectrometer (TOMS) satellite instrument with the SeaWIFS satellite ocean-color measurements in the visible spectral region. In this paper we propose a model of seawater optical properties in the UV spectral region based on the Case I water model in the visible range. The inputs to the model are standard monthly SeaWiFS products: chlorophyll concentration and the diffuse attenuation coefficient at 490nm. Penetration of solar UV radiation to different depths in open ocean waters is calculated using the RT (radiative transfer) quasi-single scattering approximation (QSSA). The accuracy of the QSSA approximation in the water is tested using more accurate codes. The sensitivity study of the underwater UV irradiance to atmospheric and oceanic optical properties have shown that the main environmental parameters controlling the absolute levels of the UVB (280-320nm) and DNA-weighted irradiance underwater are: solar-zenith angle, cloud transmittance, water optical properties, and total ozone. Weekly maps of underwater UV irradiance and DNA-weighted exposure are calculated using monthly-mean SeaWiFS chlorophyll and diffuse attenuation coefficient products, daily SeaWiFS cloud fraction data, and the TOMS-derived surface UV irradiance daily maps. The final products include global maps of weekly-average UVB irradiance and DNA-weighted daily exposures at 3m and 10m, and depths where the UVB irradiance and DNA-weighted dose rate at local noon are equal to 10% of their surface values.

  7. Creating a global sub-daily precipitation dataset

    NASA Astrophysics Data System (ADS)

    Lewis, Elizabeth; Blenkinsop, Stephen; Fowler, Hayley

    2017-04-01

    Extremes of precipitation can cause flooding and droughts which can lead to substantial damages to infrastructure and ecosystems and can result in loss of life. It is still uncertain how hydrological extremes will change with global warming as we do not fully understand the processes that cause extreme precipitation under current climate variability. The INTENSE project is using a novel and fully-integrated data-modelling approach to provide a step-change in our understanding of the nature and drivers of global precipitation extremes and change on societally relevant timescales, leading to improved high-resolution climate model representation of extreme rainfall processes. The INTENSE project is in conjunction with the World Climate Research Programme (WCRP)'s Grand Challenge on 'Understanding and Predicting Weather and Climate Extremes' and the Global Water and Energy Exchanges Project (GEWEX) Science questions. The first step towards achieving this is to construct a new global sub-daily precipitation dataset. Data collection is ongoing and already covers North America, Europe, Asia and Australasia. Comprehensive, open source quality control software is being developed to set a new standard for verifying sub-daily precipitation data and a set of global hydroclimatic indices will be produced based upon stakeholder recommendations. This will provide a unique global data resource on sub-daily precipitation whose derived indices, e.g. monthly/annual maxima, will be freely available to the wider scientific community.

  8. A 24.5-Year Global Dataset of Direct Normal Irradiance: Result from the Application of a Global-to-Beam Model to the NASA GEWEX SRB Global Horizontal Irradiance

    NASA Astrophysics Data System (ADS)

    Zhang, T.; Stackhouse, P. W.; Chandler, W.; Hoell, J. M., Jr.; Westberg, D. J.

    2015-12-01

    The DIRINDEX model has previously been applied to the NASA GEWEX SRB Release 3.0 global horizontal irradiances (GHIs) to derive 3-hourly, daily and monthly mean direct normal irradiances (DNIs) for the period from 2000 to 2005 (http://dx.doi.org/10.1016/j.solener.2014.09.006), though the model was originally designed to estimate hourly DNIs from hourly GHIs. Input to the DIRINDEX model comprised 1.) the 3-hourly all-sky and clear-sky GHIs from the GEWEX SRB dataset; 2.) the surface pressure and the atmospheric column water vapor from the GEOS4 dataset; and 3.) daily mean aerosol optical depth at 700 nm derived from the daily mean aerosol data from the Model of Atmospheric Transport and CHemistry (MATCH). The GEWEX SRB data is spatially available on a quasi-equal-area global grid system consisting of 44016 boxes ranging from 1 degree latitude by 1 degree longitude around the Equator to 1 degree latitude by 120 degree longitude next to the poles. The derived DNIs were on the same grid system. Due to the limited availability of the MATCH aerosol data, the model was applied to the years from 2000 to 2005 only. The results were compared with ground-based measurements from 39 sites of the Baseline Surface Radiation Network (BSRN). The comparison statistics show that the results were in better agreement with their BSRN counterparts than the current Surface meteorology and Solar Energy (SSE) Release 6.0 data (https://eosweb.larc.nasa.gov/sse/). In this paper, we present results from the model over the entire time span of the GEWEX SRB Release 3.0 data (July 1983 to December2007) in which the MERRA atmospheric data were substituted for the GEOS4 data, and the Max-Planck Aerosol Climatology Version 1 (MAC-v1) data for the MATCH data. As a consequence, we derived a 24.5-year DNI dataset of global coverage continuous from July 1983 to December 2007. Comparisons with the BSRN data show that the results are comparable in quality with that from the earlier application.

  9. Statistical analysis of global horizontal solar irradiation GHI in Fez city, Morocco

    NASA Astrophysics Data System (ADS)

    Bounoua, Z.; Mechaqrane, A.

    2018-05-01

    An accurate knowledge of the solar energy reaching the ground is necessary for sizing and optimizing the performances of solar installations. This paper describes a statistical analysis of the global horizontal solar irradiation (GHI) at Fez city, Morocco. For better reliability, we have first applied a set of check procedures to test the quality of hourly GHI measurements. We then eliminate the erroneous values which are generally due to measurement or the cosine effect errors. Statistical analysis show that the annual mean daily values of GHI is of approximately 5 kWh/m²/day. Daily monthly mean values and other parameter are also calculated.

  10. Prediction of global solar irradiance based on time series analysis: Application to solar thermal power plants energy production planning

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Martin, Luis; Marchante, Ruth; Cony, Marco

    2010-10-15

    Due to strong increase of solar power generation, the predictions of incoming solar energy are acquiring more importance. Photovoltaic and solar thermal are the main sources of electricity generation from solar energy. In the case of solar thermal energy plants with storage energy system, its management and operation need reliable predictions of solar irradiance with the same temporal resolution as the temporal capacity of the back-up system. These plants can work like a conventional power plant and compete in the energy stock market avoiding intermittence in electricity production. This work presents a comparisons of statistical models based on time seriesmore » applied to predict half daily values of global solar irradiance with a temporal horizon of 3 days. Half daily values consist of accumulated hourly global solar irradiance from solar raise to solar noon and from noon until dawn for each day. The dataset of ground solar radiation used belongs to stations of Spanish National Weather Service (AEMet). The models tested are autoregressive, neural networks and fuzzy logic models. Due to the fact that half daily solar irradiance time series is non-stationary, it has been necessary to transform it to two new stationary variables (clearness index and lost component) which are used as input of the predictive models. Improvement in terms of RMSD of the models essayed is compared against the model based on persistence. The validation process shows that all models essayed improve persistence. The best approach to forecast half daily values of solar irradiance is neural network models with lost component as input, except Lerida station where models based on clearness index have less uncertainty because this magnitude has a linear behaviour and it is easier to simulate by models. (author)« less

  11. High-resolution global irradiance monitoring from photovoltaic systems

    NASA Astrophysics Data System (ADS)

    Buchmann, Tina; Pfeilsticker, Klaus; Siegmund, Alexander; Meilinger, Stefanie; Mayer, Bernhard; Pinitz, Sven; Steinbrecht, Wolfgang

    2016-04-01

    Reliable and regional differentiated power forecasts are required to guarantee an efficient and economic energy transition towards renewable energies. Amongst other renewable energy technologies, e.g. wind mills, photovoltaic systems are an essential component of this transition being cost-efficient and simply to install. Reliable power forecasts are however required for a grid integration of photovoltaic systems, which among other data requires high-resolution spatio-temporal global irradiance data. Hence the generation of robust reviewed global irradiance data is an essential contribution for the energy transition. To achieve this goal our studies introduce a novel method which makes use of photovoltaic power generation in order to infer global irradiance. The method allows to determine high-resolution temporal global irradiance data (one data point every 15 minutes at each location) from power data of operated photovoltaic systems. Due to the multitude of installed photovoltaic systems (in Germany) the detailed spatial coverage is much better than for example only using global irradiance data from conventional pyranometer networks (e.g. from the German Weather Service). Our designated method is composed of two components: a forward component, i.e. to conclude from predicted global irradiance to photovoltaic (PV) power, and a backward component, i.e. from PV power with suitable calibration to global irradiance. The forward process is modelled by using the radiation transport model libRadtran (B. Mayer and A. Kylling (1)) for clear skies to obtain the characteristics (orientation, size, temperature dependence, …) of individual PV systems. For PV systems in the vicinity of a meteorological station, these data are validated against calibrated pyranometer readings. The forward-modelled global irradiance is used to determine the power efficiency for each photovoltaic system using non-linear optimisation techniques. The backward component uses the power efficiency

  12. A globally calibrated scheme for generating daily meteorology from monthly statistics: Global-WGEN (GWGEN) v1.0

    NASA Astrophysics Data System (ADS)

    Sommer, Philipp S.; Kaplan, Jed O.

    2017-10-01

    While a wide range of Earth system processes occur at daily and even subdaily timescales, many global vegetation and other terrestrial dynamics models historically used monthly meteorological forcing both to reduce computational demand and because global datasets were lacking. Recently, dynamic land surface modeling has moved towards resolving daily and subdaily processes, and global datasets containing daily and subdaily meteorology have become available. These meteorological datasets, however, cover only the instrumental era of the last approximately 120 years at best, are subject to considerable uncertainty, and represent extremely large data files with associated computational costs of data input/output and file transfer. For periods before the recent past or in the future, global meteorological forcing can be provided by climate model output, but the quality of these data at high temporal resolution is low, particularly for daily precipitation frequency and amount. Here, we present GWGEN, a globally applicable statistical weather generator for the temporal downscaling of monthly climatology to daily meteorology. Our weather generator is parameterized using a global meteorological database and simulates daily values of five common variables: minimum and maximum temperature, precipitation, cloud cover, and wind speed. GWGEN is lightweight, modular, and requires a minimal set of monthly mean variables as input. The weather generator may be used in a range of applications, for example, in global vegetation, crop, soil erosion, or hydrological models. While GWGEN does not currently perform spatially autocorrelated multi-point downscaling of daily weather, this additional functionality could be implemented in future versions.

  13. A global dataset of sub-daily rainfall indices

    NASA Astrophysics Data System (ADS)

    Fowler, H. J.; Lewis, E.; Blenkinsop, S.; Guerreiro, S.; Li, X.; Barbero, R.; Chan, S.; Lenderink, G.; Westra, S.

    2017-12-01

    It is still uncertain how hydrological extremes will change with global warming as we do not fully understand the processes that cause extreme precipitation under current climate variability. The INTENSE project is using a novel and fully-integrated data-modelling approach to provide a step-change in our understanding of the nature and drivers of global precipitation extremes and change on societally relevant timescales, leading to improved high-resolution climate model representation of extreme rainfall processes. The INTENSE project is in conjunction with the World Climate Research Programme (WCRP)'s Grand Challenge on 'Understanding and Predicting Weather and Climate Extremes' and the Global Water and Energy Exchanges Project (GEWEX) Science questions. A new global sub-daily precipitation dataset has been constructed (data collection is ongoing). Metadata for each station has been calculated, detailing record lengths, missing data, station locations. A set of global hydroclimatic indices have been produced based upon stakeholder recommendations including indices that describe maximum rainfall totals and timing, the intensity, duration and frequency of storms, frequency of storms above specific thresholds and information about the diurnal cycle. This will provide a unique global data resource on sub-daily precipitation whose derived indices will be freely available to the wider scientific community.

  14. Application of a Global-to-Beam Irradiance Model to the NASA GEWEX SRB Dataset: An Extension of the NASA Surface Meteorology and Solar Energy Datasets

    NASA Technical Reports Server (NTRS)

    Zhang, Taiping; Stackhouse, Paul W., Jr.; Chandler, William S.; Westberg, David J.

    2014-01-01

    The DIRINDEX model was designed to estimate hourly solar beam irradiances from hourly global horizontal irradiances. This model was applied to the NASA GEWEX SRB(Rel. 3.0) 3-hourly global horizontal irradiance data to derive3-hourly global maps of beam, or direct normal, irradiance for the period from January 2000 to December 2005 at the 1 deg. x 1 deg. resolution. The DIRINDEX model is a combination of the DIRINT model, a quasi-physical global-to-beam irradiance model based on regression of hourly observed data, and a broadband simplified version of the SOLIS clear-sky beam irradiance model. In this study, the input variables of the DIRINDEX model are 3-hourly global horizontal irradiance, solar zenith angle, dew-point temperature, surface elevation, surface pressure, sea-level pressure, aerosol optical depth at 700 nm, and column water vapor. The resulting values of the 3-hourly direct normal irradiance are then used to compute daily and monthly means. The results are validated against the ground-based BSRN data. The monthly means show better agreement with the BSRN data than the results from an earlier endeavor which empirically derived the monthly mean direct normal irradiance from the GEWEX SRB monthly mean global horizontal irradiance. To assimilate the observed information into the final results, the direct normal fluxes from the DIRINDEX model are adjusted according to the comparison statistics in the latitude-longitude-cosine of solar zenith angle phase space, in which the inverse-distance interpolation is used for the adjustment. Since the NASA Surface meteorology and Solar Energy derives its data from the GEWEX SRB datasets, the results discussed herein will serve to extend the former.

  15. On nonstationarity and antipersistency in global temperature series

    NASA Astrophysics Data System (ADS)

    KäRner, O.

    2002-10-01

    Statistical analysis is carried out for satellite-based global daily tropospheric and stratospheric temperature anomaly and solar irradiance data sets. Behavior of the series appears to be nonstationary with stationary daily increments. Estimating long-range dependence between the increments reveals a remarkable difference between the two temperature series. Global average tropospheric temperature anomaly behaves similarly to the solar irradiance anomaly. Their daily increments show antipersistency for scales longer than 2 months. The property points at a cumulative negative feedback in the Earth climate system governing the tropospheric variability during the last 22 years. The result emphasizes a dominating role of the solar irradiance variability in variations of the tropospheric temperature and gives no support to the theory of anthropogenic climate change. The global average stratospheric temperature anomaly proceeds like a 1-dim random walk at least up to 11 years, allowing good presentation by means of the autoregressive integrated moving average (ARIMA) models for monthly series.

  16. On the diffuse fraction of daily and monthly global radiation for the island of Cyprus

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Jacovides, C.P.; Hadjioannou, L.; Pashiardis, S.

    1996-06-01

    Six years of hourly global and diffuse irradiation measurements on a horizontal surface performed at Athalassa, Cyprus, are used to establish a relationship between the daily diffuse fraction and the daily clearness index. Two types of correlations - yearly and seasonal - have been developed. These correlations, of first and third order in the clearness index are compared to the various correlations established by Collares-Pereira and Rabl (1979), Newland (1989), Erbs et al. (1982), Rao et al. (1984), Page (1961), Liu and Jordan (1960) and Lalas et al. (1987). The comparison has been performed in terms of the widely usedmore » statistical indicators (MBE) and (RMSE) errors; and additional statistical indicator, the t-statistic, combining the earlier indicators, is introduced. The results indicate that the proposed yearly correlation matches the earlier correlations quite closely and all correlations examined yield results that are statistically significant. For large K{sub t} > 0.60 values, most of the earlier correlations exhibit a slight tendency to systematically overestimate the diffuse fraction. This marginal disagreement between the earlier correlations and the proposed model is probably significantly affected by the clear sky conditions that prevail over Cyprus for most of the time as well as atmospheric humidity content. It is clear that the standard correlations examined in this analysis appear to be location-independent models for diffuse irradiation predictions, at least for the Cyprus case. 13 refs., 5 figs., 4 tabs.« less

  17. Determination of Semivariogram Models to Krige Hourly and Daily Solar Irradiance in Western Nebraska(.

    NASA Astrophysics Data System (ADS)

    Merino, G. G.; Jones, D.; Stooksbury, D. E.; Hubbard, K. G.

    2001-06-01

    In this paper, linear and spherical semivariogram models were determined for use in kriging hourly and daily solar irradiation for every season of the year. The data used to generate the models were from 18 weather stations in western Nebraska. The models generated were tested using cross validation. The performance of the spherical and linear semivariogram models were compared with each other and also with the semivariogram models based on the best fit to the sample semivariogram of a particular day or hour. There were no significant differences in the performance of the three models. This result and the comparable errors produced by the models in kriging indicated that the linear and spherical models could be used to perform kriging at any hour and day of the year without deriving an individual semivariogram model for that day or hour.The seasonal mean absolute errors associated with kriging, within the network, when using the spherical or the linear semivariograms models were between 10% and 13% of the mean irradiation for daily irradiation and between 12% and 20% for hourly irradiation. These errors represent an improvement of 1%-2% when compared with replacing data at a given site with the data of the nearest weather station.

  18. Comparison of several databases of downward solar daily irradiation data at ocean surface with PIRATA measurements

    NASA Astrophysics Data System (ADS)

    Trolliet, Mélodie; Wald, Lucien

    2017-04-01

    The solar radiation impinging at sea surface is an essential variable in climate system. There are several means to assess the daily irradiation at surface, such as pyranometers aboard ship or on buoys, meteorological re-analyses and satellite-derived databases. Among the latter, assessments made from the series of geostationary Meteosat satellites offer synoptic views of the tropical and equatorial Atlantic Ocean every 15 min with a spatial resolution of approximately 5 km. Such Meteosat-derived databases are fairly recent and the quality of the estimates of the daily irradiation must be established. Efforts have been made for the land masses and must be repeated for the Atlantic Ocean. The Prediction and Research Moored Array in the Tropical Atlantic (PIRATA) network of moorings in the Tropical Atlantic Ocean is considered as a reference for oceanographic data. It consists in 17 long-term Autonomous Temperature Line Acquisition System (ATLAS) buoys equipped with sensors to measure near-surface meteorological and subsurface oceanic parameters, including downward solar irradiation. Corrected downward solar daily irradiation from PIRATA were downloaded from the NOAA web site and were compared to several databases: CAMS RAD, HelioClim-1, HelioClim-3 v4 and HelioClim-3 v5. CAMS-RAD, the CAMS radiation service, combines products of the Copernicus Atmosphere Monitoring Service (CAMS) on gaseous content and aerosols in the atmosphere together with cloud optical properties deduced every 15 min from Meteosat imagery to supply estimates of the solar irradiation. Part of this service is the McClear clear sky model that provides estimates of the solar irradiation that should be observed in cloud-free conditions. The second and third databases are HelioClim-1 and HelioClim-3 v4 that are derived from Meteosat images using the Heliosat-2 method and the ESRA clear sky model, based on the Linke turbidity factor. HelioClim-3 v5 is the fourth database and differs from v4 by the

  19. Evaluation of Daily Extreme Precipitation Derived From Long-term Global Satellite Quantitative Precipitation Estimates (QPEs)

    NASA Astrophysics Data System (ADS)

    Prat, O. P.; Nelson, B. R.; Nickl, E.; Ferraro, R. R.

    2017-12-01

    This study evaluates the ability of different satellite-based precipitation products to capture daily precipitation extremes over the entire globe. The satellite products considered are the datasets belonging to the Reference Environmental Data Records (REDRs) program (PERSIANN-CDR, GPCP, CMORPH, AMSU-A,B, Hydrologic bundle). Those products provide long-term global records of daily adjusted Quantitative Precipitation Estimates (QPEs) that range from 20-year (CMORPH-CDR) to 35-year (PERSIANN-CDR, GPCP) record of daily adjusted global precipitation. The AMSU-A,B, Hydro-bundle is an 11-year record of daily rain rate over land and ocean, snow cover and surface temperature over land, and sea ice concentration, cloud liquid water, and total precipitable water over ocean among others. The aim of this work is to evaluate the ability of the different satellite QPE products to capture daily precipitation extremes. This evaluation will also include comparison with in-situ data sets at the daily scale from the Global Historical Climatology Network (GHCN-Daily), the Global Precipitation Climatology Centre (GPCC) gridded full data daily product, and the US Climate Reference Network (USCRN). In addition, while the products mentioned above only provide QPEs, the AMSU-A,B hydro-bundle provides additional hydrological information (precipitable water, cloud liquid water, snow cover, sea ice concentration). We will also present an analysis of those additional variables available from global satellite measurements and their relevance and complementarity in the context of long-term hydrological and climate studies.

  20. Global Precipitation at One-Degree Daily Resolution From Multi-Satellite Observations

    NASA Technical Reports Server (NTRS)

    Huffman, George J.; Adler, Robert F.; Morrissey, Mark M.; Curtis, Scott; Joyce, Robert; McGavock, Brad; Susskind, Joel

    2000-01-01

    The One-Degree Daily (1DD) technique is described for producing globally complete daily estimates of precipitation on a 1 deg x 1 deg lat/long grid from currently available observational data. Where possible (40 deg N-40 deg S), the Threshold-Matched Precipitation Index (TMPI) provides precipitation estimates in which the 3-hourly infrared brightness temperatures (IR T(sub b)) are thresholded and all "cold" pixels are given a single precipitation rate. This approach is an adaptation of the Geostationary Operational Environmental Satellite (GOES) Precipitation Index (GPI), but for the TMPI the IR Tb threshold and conditional rain rate are set locally by month from Special Sensor Microwave/Imager (SSM/I)-based precipitation frequency and the Global Precipitation Climatology Project (GPCP) satellite-gauge (SG) combined monthly precipitation estimate, respectively. At higher latitudes the 1DD features a rescaled daily Television Infrared Observation Satellite (TIROS) Operational Vertical Sounder (TOVS) precipitation. The frequency of rain days in the TOVS is scaled down to match that in the TMPI at the data boundaries, and the resulting non-zero TOVS values are scaled locally to sum to the SG (which is a globally complete monthly product). The time series of the daily 1DD global images shows good continuity in time and across the data boundaries. Various examples are shown to illustrate uses. Validation for individual grid -box values shows a very high root-mean-square error but, it improves quickly when users perform time/space averaging according to their own requirements.

  1. Reducing Noise in the MSU Daily Lower-Tropospheric Global Temperature Dataset

    NASA Technical Reports Server (NTRS)

    Christy, John R.; Spencer, Roy W.; McNider, Richard T.

    1996-01-01

    The daily global-mean values of the lower-tropospheric temperature determined from microwave emissions measured by satellites are examined in terms of their signal, noise, and signal-to-noise ratio. Daily and 30-day average noise estimates are reduced by almost 50% and 35%. respectively, by analyzing and adjusting (if necessary) for errors due to 1) missing data, 2) residual harmonics of the annual cycle unique to particular satellites, 3) lack of filtering, and 4) spurious trends. After adjustments, the decadal trend of the lower-tropospheric global temperature from January 1979 through February 1994 becomes -0.058 C. or about 0.03 C per decade cooler than previously calculated.

  2. Reducing Noise in the MSU Daily Lower-Tropospheric Global Temperature Dataset

    NASA Technical Reports Server (NTRS)

    Christy, John R.; Spencer, Roy W.; McNider, Richard T.

    1995-01-01

    The daily global-mean values of the lower-tropospheric temperature determined from microwave emissions measured by satellites are examined in terms of their signal, noise, and signal-to-noise ratio. Daily and 30-day average noise estimates are reduced by, almost 50% and 35%, respectively, by analyzing and adjusting (if necessary) for errors due to (1) missing data, (2) residual harmonics of the annual cycle unique to particular satellites, (3) lack of filtering, and (4) spurious trends. After adjustments, the decadal trend of the lower-tropospheric global temperature from January 1979 through February 1994 becomes -0.058 C, or about 0.03 C per decade cooler than previously calculated.

  3. Effects of cloudiness on global and diffuse UV irradiance in a high-mountain area

    NASA Astrophysics Data System (ADS)

    Blumthaler, M.; Ambach, W.; Salzgeber, M.

    1994-03-01

    At the high-mountain station Jungfraujoch (3576 m a.s.l., Switzerland), measurements of the radiation fluxes were made during 16 periods of six to eight weeks by means of a Robertson—Berger sunburn meter (UVB data), an Eppley UVA radiometer and an Eppley pyranometer. Cloudiness, opacity and altitude of clouds were recorded at 30-minute intervals. A second set of instruments was employed for separate measurement of the diffuse radiation fluxes using shadow bands. The global and diffuse UVA- and UVB radiation fluxes change less with cloudiness than the corresponding total radiation fluxes. When the sun is covered by clouds, the global UVA- and UVB radiation fluxes are also affected less than the global total radiation flux. The roughly equal influence of cloudiness on the UVA- and UVB radiation fluxes suggests that the reduction is influenced more by scattering than by ozone. Also, the share of diffuse irradiance in global irradiance is considerably higher for UVA- and UVB irradiance than for total irradiance. At 50° solar elevation and 0/10 cloudiness, the share is 39% for UVB irradiance, 34% for UVA irradiance and 11% for total irradiance. The increased aerosol turbidity after the eruptions of El Chichon and Pinatubo has caused a significant increase in diffuse total irradiance but has not produced any significant changes in diffuse UVA- and UVB irradiances.

  4. Hematopoietic responses under protracted exposures to low daily dose gamma irradiation

    NASA Astrophysics Data System (ADS)

    Seed, T. M.; Fritz, T. E.; Tolle, D. V.; Jackson, W. E.

    In attempting to evaluate the possible health consequences of chronic ionizing radiation exposure during extended space travel (e.g., Mars Mission), ground-based experimental studies of the clinical and pathological responses of canines under low daily doses of 60Co gamma irradiation (0.3-26.3 cGy d -1) have been examined. Specific reference was given to responses of the blood forming system. Results suggest that the daily dose rate of 7.5 cGy d -1 represents a threshold below which the hematopoietic system can retain either partial or full trilineal cell-producing capacity (erythropoiesis, myelopoiesis, and megakaryopoiesis) for extended periods of exposure (> 1yr). Trilineal capacity was fully retained for several years of exposure at the lowest dose-rate tested (0.3 cGy d -1) but was completely lost within several hundred days at the highest dose-rate (26.3 cGy d -1). Retention of hematopoietic capacity under chronic exposure has been demonstrated to be mediated by hematopoietic progenitors with acquired radioresistance and repair functions, altered cytogenetics, and cell-cycle characteristics. Radiological, biological, and temporal parameters responsible for these vital acquisitions by hematopoietic progenitors have been partially characterized. These parameters, along with threshold responses, are described and discussed in relation to potential health risks of the space traveler under chronic stress of low-dose irradiation.

  5. Hematopoietic responses under protracted exposures to low daily dose gamma irradiation.

    PubMed

    Seed, T M; Fritz, T E; Tolle, D V; Jackson, W E

    2002-01-01

    In attempting to evaluate the possible health consequences of chronic ionizing radiation exposure during extended space travel (e.g., Mars Mission), ground-based experimental studies of the clinical and pathological responses of canines under low daily doses of 60Co gamma irradiation (0.3-26.3 cGy d-1) have been examined. Specific reference was given to responses of the blood forming system. Results suggest that the daily dose rate of 7.5 cGy d-1 represents a threshold below which the hematopoietic system can retain either partial or full trilineal cell-producing capacity (erythropoiesis, myelopoiesis, and megakaryopoiesis) for extended periods of exposure (>1 yr). Trilineal capacity was fully retained for several years of exposure at the lowest dose-rate tested (0.3 cGy d-1) but was completely lost within several hundred days at the highest dose-rate (26.3 cGy d-1). Retention of hematopoietic capacity under chronic exposure has been demonstrated to be mediated by hematopoietic progenitors with acquired radioresistance and repair functions, altered cytogenetics, and cell-cycle characteristics. Radiological, biological, and temporal parameters responsible for these vital acquisitions by hematopoietic progenitors have been partially characterized. These parameters, along with threshold responses, are described and discussed in relation to potential health risks of the space traveler under chronic stress of low-dose irradiation. Published by Elsevier Science Ltd on behalf of COSPAR.

  6. Usefulness of Daily Fractionated Administration of Wortmannin Combined With γ-Ray Irradiation in Terms of Local Tumor Response and Lung Metastasis

    PubMed Central

    Masunaga, Shin-ichiro; Sakurai, Yoshinori; Tanaka, Hiroki; Suzuki, Minoru; Kondo, Natsuko; Narabayashi, Masaru; Tano, Keizo; Maruhashi, Akira; Ono, Koji

    2013-01-01

    Background To evaluate the usefulness of fractionated administration of wortmannin combined with γ-ray irradiation in terms of local tumor response and lung metastatic potential, referring to the response of intratumor quiescent (Q) cells. Methods B16-BL6 melanoma tumor-bearing C57BL/6 mice were continuously given 5-bromo-2’-deoxyuridine (BrdU) to label all proliferating (P) cells. The tumor-bearing mice then received γ-ray irradiation after wortmannin treatment through a single or 4 consecutive daily intraperitoneal administrations up to a total dose of 4 mg/kg in combination with an acute hypoxia-releasing agent (nicotinamide) or mild temperature hyperthermia (MTH). Immediately after the irradiation, cells from some tumors were isolated and incubated with a cytokinesis blocker. The responses of the Q and total (= P + Q) cell populations were assessed based on the frequency of micronuclei using immunofluorescence staining for BrdU. In other tumor-bearing mice, 17 days after irradiation, macroscopic lung metastases were enumerated. Results Wortmannin raised the sensitivity of Q cells more remarkably than the total cell population in both single and daily administrations. Daily administration of wortmannin elevated the sensitivity of both the total and Q cell populations, but especially the total cell population, compared with single administration. Daily administration, especially combined with MTH, decreased the number of lung metastases. Conclusion Daily fractionated administration of wortmannin in combination with γ-ray irradiation was thought to be more promising than single administration because of its potential to enhance local tumor response and repress lung metastatic potential. PMID:29147327

  7. A global gridded dataset of daily precipitation going back to 1950, ideal for analysing precipitation extremes

    NASA Astrophysics Data System (ADS)

    Contractor, S.; Donat, M.; Alexander, L. V.

    2017-12-01

    Reliable observations of precipitation are necessary to determine past changes in precipitation and validate models, allowing for reliable future projections. Existing gauge based gridded datasets of daily precipitation and satellite based observations contain artefacts and have a short length of record, making them unsuitable to analyse precipitation extremes. The largest limiting factor for the gauge based datasets is a dense and reliable station network. Currently, there are two major data archives of global in situ daily rainfall data, first is Global Historical Station Network (GHCN-Daily) hosted by National Oceanic and Atmospheric Administration (NOAA) and the other by Global Precipitation Climatology Centre (GPCC) part of the Deutsche Wetterdienst (DWD). We combine the two data archives and use automated quality control techniques to create a reliable long term network of raw station data, which we then interpolate using block kriging to create a global gridded dataset of daily precipitation going back to 1950. We compare our interpolated dataset with existing global gridded data of daily precipitation: NOAA Climate Prediction Centre (CPC) Global V1.0 and GPCC Full Data Daily Version 1.0, as well as various regional datasets. We find that our raw station density is much higher than other datasets. To avoid artefacts due to station network variability, we provide multiple versions of our dataset based on various completeness criteria, as well as provide the standard deviation, kriging error and number of stations for each grid cell and timestep to encourage responsible use of our dataset. Despite our efforts to increase the raw data density, the in situ station network remains sparse in India after the 1960s and in Africa throughout the timespan of the dataset. Our dataset would allow for more reliable global analyses of rainfall including its extremes and pave the way for better global precipitation observations with lower and more transparent uncertainties.

  8. The EUSTACE project: delivering global, daily information on surface air temperature

    NASA Astrophysics Data System (ADS)

    Ghent, D.; Rayner, N. A.

    2017-12-01

    Day-to-day variations in surface air temperature affect society in many ways; however, daily surface air temperature measurements are not available everywhere. A global daily analysis cannot be achieved with measurements made in situ alone, so incorporation of satellite retrievals is needed. To achieve this, in the EUSTACE project (2015-2018, https://www.eustaceproject.eu) we have developed an understanding of the relationships between traditional (land and marine) surface air temperature measurements and retrievals of surface skin temperature from satellite measurements, i.e. Land Surface Temperature, Ice Surface Temperature, Sea Surface Temperature and Lake Surface Water Temperature. Here we discuss the science needed to produce a fully-global daily analysis (or ensemble of analyses) of surface air temperature on the centennial scale, integrating different ground-based and satellite-borne data types. Information contained in the satellite retrievals is used to create globally-complete fields in the past, using statistical models of how surface air temperature varies in a connected way from place to place. This includes developing new "Big Data" analysis methods as the data volumes involved are considerable. We will present recent progress along this road in the EUSTACE project, i.e.: • identifying inhomogeneities in daily surface air temperature measurement series from weather stations and correcting for these over Europe; • estimating surface air temperature over all surfaces of Earth from surface skin temperature retrievals; • using new statistical techniques to provide information on higher spatial and temporal scales than currently available, making optimum use of information in data-rich eras. Information will also be given on how interested users can become involved.

  9. Evaluation of various procedures transposing global tilted irradiance to horizontal surface irradiance

    NASA Astrophysics Data System (ADS)

    Housmans, Caroline; Bertrand, Cédric

    2017-02-01

    Many transposition models have been proposed in the literature to convert solar irradiance on the horizontal plane to that on a tilted plane. The inverse process, i.e. the conversion from tilted to horizontal is investigated here based upon seven months of in-plane global solar irradiance measurements recorded on the roof of the Royal Meteorological Institute of Belgium's radiation tower in Uccle (Longitude 4.35° E, Latitude 50.79° N). Up to three pyranometers mounted on inclined planes of different tilts and orientations were involved in the inverse transposition process. Our results indicate that (1) the tilt to horizontal irradiance conversion is improved when measurements from more than one tilted pyranometer are considered (i.e. by using a multi-pyranometer approach) and (2) the improvement from using an isotropic model to anisotropic models in the inverse transposition problem is not significant.

  10. Reported Exposure and Emotional Reactivity to Daily Stressors: The Roles of Adult-Age and Global Perceived Stress

    PubMed Central

    Stawski, Robert S.; Sliwinski, Martin J.; Almeida, David M.; Smyth, Joshua M.

    2012-01-01

    A central goal of daily stress research is to identify resilience and vulnerability factors associated with exposure and reactivity to daily stressors. The current study examined how age differences and global perceptions of stress relate to exposure and emotional reactivity to daily stressors. Sixty-seven younger (Mage = 20) and 116 older (Mage = 80) adults completed a daily stress diary and measures of positive and negative affect on 6 days over a 14 day period. Participants also completed a measure of global perceived stress. Results revealed that reported exposure to daily stressors is reduced in old age, but that emotional reactivity to daily stressors did not differ between young and older adults. Global perceived stress was associated with greater reported exposure to daily stressors in old adults, and greater stress-related increases in negative affect in younger adults. Furthermore, across days on which daily stressors were reported, intraindividual variability in the number and severity of stressors reported was associated with increased negative affect, but only among younger adults. PMID:18361654

  11. Reported exposure and emotional reactivity to daily stressors: the roles of adult age and global perceived stress.

    PubMed

    Stawski, Robert S; Sliwinski, Martin J; Almeida, David M; Smyth, Joshua M

    2008-03-01

    A central goal of daily stress research is to identify resilience and vulnerability factors associated with exposure and reactivity to daily stressors. The present study examined how age differences and global perceptions of stress relate to exposure and emotional reactivity to daily stressors. Sixty-seven younger (M age = 20) and 116 older (M age = 80) adults completed a daily stress diary and measures of positive and negative affect on 6 days over a 14-day period. Participants also completed a measure of global perceived stress. Results revealed that reported exposure to daily stressors is reduced in old age but that emotional reactivity to daily stressors did not differ between younger and older adults. Global perceived stress was associated with greater reported exposure to daily stressors in older adults and greater stress-related increases in negative affect in younger adults. Furthermore, across days on which daily stressors were reported, intraindividual variability in the number and severity of stressors reported was associated with increased negative affect, but only among younger adults. (c) 2008 APA, all rights reserved.

  12. Evaluation of an innovative sensor for measuring global and diffuse irradiance, and sunshine duration

    NASA Astrophysics Data System (ADS)

    Muneer, Tariq; Zhang, Xiaodong; Wood, John

    2002-03-01

    Delta-T Device Limited of Cambridge, UK have developed an integrated device which enables simultaneous measurement of horizontal global and diffuse irradiance as well as sunshine status at any given instance in time. To evaluate the performance of this new device, horizontal global and diffuse irradiance data were simultaneously collected from Delta-T device and Napier University's CIE First Class daylight monitoring station. To enable a cross check a Kipp & Zonen CM11 global irradiance sensor has also been installed in Currie, south-west Edinburgh. Sunshine duration data have been recorded at the Royal Botanical Garden, Edinburgh using their Campbell-Stokes recorder. Hourly data sets were analysed and plotted within the Microsoft Excel environment. Using the common statistical measures, Root Mean Square Difference (RMSD) and Mean Bias Difference (MBD) the accuracy of measurements of Delta-T sensor's horizontal global and diffuse irradiance, and sunshine duration were investigated. The results show a good performance on the part of Delta-T device for the measurement of global and diffuse irradiance. The sunshine measurements were found to have a lack of consistency and accuracy. It is argued herein that the distance between the respective sensors and the poor accuracy of Campbell-Stokes recorder may be contributing factors to this phenomenon.

  13. Toxicity and cosmesis following partial breast irradiation consisting of 40 Gy in 10 daily fractions.

    PubMed

    Trovo, Marco; Roncadin, Mario; Polesel, Jerry; Piccoli, Erica; Mileto, Mario; Micheli, Elvia; Perin, Tiziana; Carbone, Antonino; Massarut, Samuele; Trovo, Mauro G

    2013-10-01

    To assess the toxicity and cosmetic results in breast cancer patients undergoing adjuvant partial breast irradiation (PBI) to a total dose of 40 Gy in 10 daily fractions (4 Gy/fraction). Patients affected by early-stage breast cancer were enrolled in this phase II trial. Patients had to be 60 years old and treated with breast conservative surgery for early stage (pT1-T2 pN0-N1a) invasive ductal carcinoma. 77 patients were enrolled. Median follow-up was 18 months. The proposed schedule was well tolerated. One patient reported Grade 3 pain at the site of irradiation. Four (5%) patients experience Grade 2 erythema. Late Grade 2 and 1 fibrosis was observed in 3 (4%) and 14 (18%) patients, respectively. Cosmesis was judged "good/excellent" and "poor" in 75 (97%) and in 2 (3%) patients, respectively. 40 Gy in 10 daily fractions, 4 Gy/fraction, is a well tolerated regimen to deliver PBI. Copyright © 2013 Elsevier Ltd. All rights reserved.

  14. The EUSTACE project: delivering global, daily information on surface air temperature

    NASA Astrophysics Data System (ADS)

    Rayner, Nick

    2017-04-01

    Day-to-day variations in surface air temperature affect society in many ways; however, daily surface air temperature measurements are not available everywhere. A global daily analysis cannot be achieved with measurements made in situ alone, so incorporation of satellite retrievals is needed. To achieve this, in the EUSTACE project (2015-June 2018, https://www.eustaceproject.eu) we are developing an understanding of the relationships between traditional (land and marine) surface air temperature measurements and retrievals of surface skin temperature from satellite measurements, i.e. Land Surface Temperature, Ice Surface Temperature, Sea Surface Temperature and Lake Surface Water Temperature. Here we discuss the science needed to produce a fully-global daily analysis (or ensemble of analyses) of surface air temperature on the centennial scale, integrating different ground-based and satellite-borne data types. Information contained in the satellite retrievals is used to create globally-complete fields in the past, using statistical models of how surface air temperature varies in a connected way from place to place. As the data volumes involved are considerable, such work needs to include development of new "Big Data" analysis methods. We will present recent progress along this road in the EUSTACE project: 1. providing new, consistent, multi-component estimates of uncertainty in surface skin temperature retrievals from satellites; 2. identifying inhomogeneities in daily surface air temperature measurement series from weather stations and correcting for these over Europe; 3. estimating surface air temperature over all surfaces of Earth from surface skin temperature retrievals; 4. using new statistical techniques to provide information on higher spatial and temporal scales than currently available, making optimum use of information in data-rich eras. Information will also be given on how interested users can become involved.

  15. The EUSTACE project: delivering global, daily information on surface air temperature

    NASA Astrophysics Data System (ADS)

    Ghent, D.; Rayner, N. A.

    2016-12-01

    Day-to-day variations in surface air temperature affect society in many ways; however, daily surface air temperature measurements are not available everywhere. A global daily analysis cannot be achieved with measurements made in situ alone, so incorporation of satellite retrievals is needed. To achieve this, in the EUSTACE project (2015-June 2018, https://www.eustaceproject.eu) we are developing an understanding of the relationships between traditional (land and marine) surface air temperature measurements and retrievals of surface skin temperature from satellite measurements, i.e. Land Surface Temperature, Ice Surface Temperature, Sea Surface Temperature and Lake Surface Water Temperature. Here we discuss the science needed to produce a fully-global daily analysis (or ensemble of analyses) of surface air temperature on the centennial scale, integrating different ground-based and satellite-borne data types. Information contained in the satellite retrievals is used to create globally-complete fields in the past, using statistical models of how surface air temperature varies in a connected way from place to place. As the data volumes involved are considerable, such work needs to include development of new "Big Data" analysis methods. We will present recent progress along this road in the EUSTACE project, i.e.: • providing new, consistent, multi-component estimates of uncertainty in surface skin temperature retrievals from satellites; • identifying inhomogeneities in daily surface air temperature measurement series from weather stations and correcting for these over Europe; • estimating surface air temperature over all surfaces of Earth from surface skin temperature retrievals; • using new statistical techniques to provide information on higher spatial and temporal scales than currently available, making optimum use of information in data-rich eras. Information will also be given on how interested users can become involved.

  16. Analysis of direct to diffuse partitioning of global solar irradiance at the radiometric station in Badajoz (Spain)

    NASA Astrophysics Data System (ADS)

    Sanchez, G.; Cancillo, M. L.; Serrano, A.

    2010-09-01

    This study is aimed at the analysis of the partitioning of global solar irradiance into its direct and diffuse components at the radiometric station in Badajoz (Spain). The detailed knowledge of the solar radiation field is of increasing interest in Southern Europe due to its use as renewable energy. In particular, the knowledge of the solar radiation partitioning into direct and diffuse radiation has become a major demand for the design and suitable orientation of solar panels in solar power plants. In this study the first measurements of solar diffuse irradiance performed in the radiometric station in Badajoz (Spain) are presented and analyzed in the framework of the partitioning of solar global radiation. Thus, solar global and diffuse irradiance were measured at one-minute basis from 23 November 2009 to 31 March 2010. Solar irradiances were measured by two Kipp&Zonen CMP11 pyranometers, using a Kipp&Zonen CM121 shadow ring for the measurements of solar diffuse irradiance. Diffuse measurements were corrected from the solid angle hidden by the ring and direct irradiance was calculated as the difference between global and diffuse measurements. Irradiance was obtained from the pyranomenters by applying calibration coefficients obtained in an inter-comparison campaign performed at INTA/El Arenosillo, in Huelva (Spain), last September 2009. There, calibration coefficients were calculated using as a reference a CMP11 pyranometer which had been previously calibrated by the Physikalisch-Meteorologisches Observatorium Davos/World Radiation Centre in Switzerland. In order to study the partitioning of the solar radiation, the global and diffuse irradiances have been analyzed for three typical different sky conditions: cloud-free, broken clouds and overcast. Particular days within the period of study have been selected by visual inspection. Along with the analysis of the global and diffuse irradiances themselves, ratios of these irradiances to the downward irradiance at the

  17. Tilt to horizontal global solar irradiance conversion: application to PV systems data

    NASA Astrophysics Data System (ADS)

    Housmans, Caroline; Leloux, Jonathan; Bertrand, Cédric

    2017-04-01

    Many transposition models have been proposed in the literature to convert solar irradiance on the horizontal plane to that on a tilted plane requiring that at least two of the three solar components (i.e. global, direct and diffuse) are known. When only global irradiance measurements are available, the conversion from horizontal to tilted planes is still possible but in this case transposition models have to be coupled with decomposition models (i.e. models that predict the direct and diffuse components from the global one). Here, two different approaches have been considered to solve the reverse process, i.e. the conversion from tilted to horizontal: (i) one-sensor approach and (ii) multi-sensors approach. Because only one tilted plane is involved in the one-sensor approach, a decomposition model need to be coupled with a transposition model to solve the problem. By contrast, at least two tilted planes being considered in the multi-sensors approach, only a transposition model is required to perform the conversion. First, global solar irradiance measurements recorded on the roof of the Royal Meteorological Institute of Belgium's radiation tower in Uccle were used to evaluate the performance of both approaches. Four pyranometers (one mounted in the horizontal plane and three on inclined surfaces with different tilts and orientations) were involved in the validation exercise. Second, the inverse transposition was applied to tilted global solar irradiance values retrieved from the energy production registered at residential PV systems located in the vicinity of Belgian radiometric stations operated by RMI (for validation purposes).

  18. DAPAGLOCO - A global daily precipitation dataset from satellite and rain-gauge measurements

    NASA Astrophysics Data System (ADS)

    Spangehl, T.; Danielczok, A.; Dietzsch, F.; Andersson, A.; Schroeder, M.; Fennig, K.; Ziese, M.; Becker, A.

    2017-12-01

    The BMBF funded project framework MiKlip(Mittelfristige Klimaprognosen) develops a global climate forecast system on decadal time scales for operational applications. Herein, the DAPAGLOCO project (Daily Precipitation Analysis for the validation of Global medium-range Climate predictions Operationalized) provides a global precipitation dataset as a combination of microwave-based satellite measurements over ocean and rain gauge measurements over land on daily scale. The DAPAGLOCO dataset is created for the evaluation of the MiKlip forecast system in the first place. The HOAPS dataset (Hamburg Ocean Atmosphere Parameter and Fluxes from Satellite data) is used for the derivation of precipitation rates over ocean and is extended by the use of measurements from TMI, GMI, and AMSR-E, in addition to measurements from SSM/I and SSMIS. A 1D-Var retrieval scheme is developed to retrieve rain rates from microwave imager data, which also allows for the determination of uncertainty estimates. Over land, the GPCC (Global Precipitation Climatology Center) Full Data Daily product is used. It consists of rain gauge measurements that are interpolated on a regular grid by ordinary Kriging. The currently available dataset is based on a neuronal network approach, consists of 21 years of data from 1988 to 2008 and is currently extended until 2015 using the 1D-Var scheme and with improved sampling. Three different spatial resolved dataset versions are available with 1° and 2.5° global, and 0.5° for Europe. The evaluation of the MiKlip forecast system by DAPAGLOCO is based on ETCCDI (Expert Team on Climate Change and Detection Indices). Hindcasts are used for the index-based comparison between model and observations. These indices allow for the evaluation of precipitation extremes, their spatial and temporal distribution as well as for the duration of dry and wet spells, average precipitation amounts and percentiles on global scale. Besides, an ETCCDI-based climatology of the DAPAGLOCO

  19. Global daily reference evapotranspiration modeling and evaluation

    USGS Publications Warehouse

    Senay, G.B.; Verdin, J.P.; Lietzow, R.; Melesse, Assefa M.

    2008-01-01

    Accurate and reliable evapotranspiration (ET) datasets are crucial in regional water and energy balance studies. Due to the complex instrumentation requirements, actual ET values are generally estimated from reference ET values by adjustment factors using coefficients for water stress and vegetation conditions, commonly referred to as crop coefficients. Until recently, the modeling of reference ET has been solely based on important weather variables collected from weather stations that are generally located in selected agro-climatic locations. Since 2001, the National Oceanic and Atmospheric Administration’s Global Data Assimilation System (GDAS) has been producing six-hourly climate parameter datasets that are used to calculate daily reference ET for the whole globe at 1-degree spatial resolution. The U.S. Geological Survey Center for Earth Resources Observation and Science has been producing daily reference ET (ETo) since 2001, and it has been used on a variety of operational hydrological models for drought and streamflow monitoring all over the world. With the increasing availability of local station-based reference ET estimates, we evaluated the GDAS-based reference ET estimates using data from the California Irrigation Management Information System (CIMIS). Daily CIMIS reference ET estimates from 85 stations were compared with GDAS-based reference ET at different spatial and temporal scales using five-year daily data from 2002 through 2006. Despite the large difference in spatial scale (point vs. ∼100 km grid cell) between the two datasets, the correlations between station-based ET and GDAS-ET were very high, exceeding 0.97 on a daily basis to more than 0.99 on time scales of more than 10 days. Both the temporal and spatial correspondences in trend/pattern and magnitudes between the two datasets were satisfactory, suggesting the reliability of using GDAS parameter-based reference ET for regional water and energy balance studies in many parts of the world

  20. A Global Solar Irradiance Climatology of an Intermountain Region.

    DTIC Science & Technology

    1986-01-01

    D-A!171 97 A GLOBAL SOLAIR IRRRDIANCE CLIMATOLOGY OF AN INTERMOUNTAIN REGION(U) AIR FORCE INST OF TECH MRIGHT-PATTERSON APR ON E W DOBRY 1986...DD~ I JAN 73 1473 EDITION OF I NOV 65 IS OBSOLETE SECURITY CLASSIFICATION OF THIS PAGE Denfata E1ilered) %.ir.. , t . ~. ~ ~ ~ $~:V ( e vis ABSTRACT...Professor: Dr. G. E . Bingham De artment: Soil Science and Biometeorology A global solar irradiance climatology of an intermountain region is developed using

  1. Hematopoietic tissue repair under chronic low daily dose irradiation

    NASA Astrophysics Data System (ADS)

    Seed, T. M.

    The capacity of the hematopoietic system to repair constantly accruing cellular damage under chronic, low daily dose gamma irradiation is essential for the maintenance of a functional hematopoietic system, and, in turn, long term survival. In certain individuals, however, such continuous cycles of damage and repair provide an essential inductive environment for selected types of hematopathologies, e.g., myeloid leukemia (ML). In our laboratory we have been studying temporal and causal relationships between hematopoietic capacity, associated repair functions, and propensities for hematologic disease in canines under variable levels of chronic radiation stress (0.3-26.3 cGy d^-1). Results indicate that the maximum exposure rate tolerated by the hematopoietic system is highly individual-specific (three major responding subgroups identified) and is based largely on the degree to which repair capacity, and, in turn, hematopoietic restoration, is augmented under chronic exposure. In low-tolerance individuals (prone to aplastic anemia, subgroup 1), the failure to augment basic repair functions seemingly results in a progressive accumulation of genetic and cellular damage within vital progenitorial marrow compartments (particularly marked within erythroid compartments) that results in loss of reproductive capacity and ultimately in collapse of the hematopoietic system. The high-tolerance individuals (radioaccommodated and either prone- or not prone to ML, subgroup 2 & 3) appear to minimize the accumulating damage effect of daily exposures by extending repair functions, which preserves reproductive integrity and fosters regenerative hematopoietic responses. As the strength of the regenerative response manifests the extent of repair augmentation, the relatively strong response of high-tolerance individuals progressing to patent ML suggests an insufficiency of repair quality rather than repair quantity. The kinetics of these repair-mediated, regenerative hematopoietic

  2. White Paper on SBUV/2 Solar Irradiance Measurements

    NASA Technical Reports Server (NTRS)

    Hilsenrath, Ernest; DeLand, Matthew T.; Cebula, Richard P.

    1996-01-01

    The importance of solar irradiance measurements by the Solar Backscatter Ultraviolet, Model 2 (SBUV/2) instruments on NOAA's operational satellites is described. These measurements are necessary accurately monitor the long-term changes in the global column ozone amount, the altitude distribution of ozone in the upper stratosphere, and the degree to which ozone changes are caused by anthropogenic sources. Needed to accomplish these goals are weekly solar irradiance measurements at the operational ozone wavelengths, daily measurements of the Mg II proxy index, instrument-specific Mg II scale factors, and daily measurements of the solar spectral irradiance at photochemically important wavelengths. Two solar measurement schedules are provided: (1) a baseline schedule for all instruments except the NOAA-14 instrument and (2) a modified schedule for the NOAA-14 SBUV/2 instrument. This latter schedule is needed due to the NOAA-14 grating drive problems.

  3. [Comparison of three daily global solar radiation models].

    PubMed

    Yang, Jin-Ming; Fan, Wen-Yi; Zhao, Ying-Hui

    2014-08-01

    Three daily global solar radiation estimation models ( Å-P model, Thornton-Running model and model provided by Liu Ke-qun et al.) were analyzed and compared using data of 13 weather stations from 1982 to 2012 from three northeastern provinces and eastern Inner Mongolia. After cross-validation analysis, the result showed that mean absolute error (MAE) for each model was 1.71, 2.83 and 1.68 MJ x m(-2) x d(-1) respectively, showing that Å-P model and model provided by Liu Ke-qun et al. which used percentage of sunshine had an advantage over Thornton-Running model which didn't use percentage of sunshine. Model provided by Liu Ke-qun et al. played a good effect on the situation of non-sunshine, and its MAE and bias percentage were 18.5% and 33.8% smaller than those of Å-P model, respectively. High precision results could be obtained by using the simple linear model of Å-P. Å-P model, Thornton-Running model and model provided by Liu Ke-qun et al. overvalued daily global solar radiation by 12.2%, 19.2% and 9.9% respectively. MAE for each station varied little with the spatial change of location, and annual MAE decreased with the advance of years. The reason for this might be that the change of observation accuracy caused by the replacement of radiation instrument in 1993. MAEs for rainy days, non-sunshine days and warm seasons of the three models were greater than those for days without rain, sunshine days and cold seasons respectively, showing that different methods should be used for different weather conditions on estimating solar radiation with meteorological elements.

  4. Evaluation of global horizontal irradiance to plane-of-array irradiance models at locations across the United States

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lave, Matthew; Hayes, William; Pohl, Andrew

    2015-02-02

    We report an evaluation of the accuracy of combinations of models that estimate plane-of-array (POA) irradiance from measured global horizontal irradiance (GHI). This estimation involves two steps: 1) decomposition of GHI into direct and diffuse horizontal components and 2) transposition of direct and diffuse horizontal irradiance (DHI) to POA irradiance. Measured GHI and coincident measured POA irradiance from a variety of climates within the United States were used to evaluate combinations of decomposition and transposition models. A few locations also had DHI measurements, allowing for decoupled analysis of either the decomposition or the transposition models alone. Results suggest that decompositionmore » models had mean bias differences (modeled versus measured) that vary with climate. Transposition model mean bias differences depended more on the model than the location. Lastly, when only GHI measurements were available and combinations of decomposition and transposition models were considered, the smallest mean bias differences were typically found for combinations which included the Hay/Davies transposition model.« less

  5. Global spectral irradiance variability and material discrimination at Boulder, Colorado.

    PubMed

    Pan, Zhihong; Healey, Glenn; Slater, David

    2003-03-01

    We analyze 7,258 global spectral irradiance functions over 0.4-2.2 microm that were acquired over a wide range of conditions at Boulder, Colorado, during the summer of 1997. We show that low-dimensional linear models can be used to capture the variability in these spectra over both the visible and the 0.4-2.2 microm spectral ranges. Using a linear model, we compare the Boulder data with the previous study of Judd et al. [J. Opt. Soc. Am. 54, 1031 (1964)] over the visible wavelengths. We also examine the agreement of the Boulder data with a spectral database generated by using the MODTRAN 4.0 radiative transfer code. We use a database of 223 minerals to consider the effect of the spectral variability in the global spectral irradiance functions on hyperspectral material identification. We show that the 223 minerals can be discriminated accurately over the variability in the Boulder data with subspace projection techniques.

  6. Probing the photoresponse of individual Nb2O5 nanowires with global and localized laser beam irradiation.

    PubMed

    Tamang, Rajesh; Varghese, Binni; Mhaisalkar, Subodh G; Tok, Eng Soon; Sow, Chorng Haur

    2011-03-18

    Photoresponse of isolated Nb(2)O(5) nanowires (NW) padded with platinum (Pt) at both ends were studied with global irradiation by a laser beam and localized irradiation using a focused laser beam. Global laser irradiation on individual NW in ambient and vacuum conditions revealed photocurrent contributions with different time characteristics (rapid and slowly varying components) arising from defect level excitations, thermal heating effect, surface states and NW-Pt contacts. With a spot size of < 1 µm, localized irradiation highlighted the fact that the measured photocurrent in this single NW device (with and without applied bias) depended sensitively on the photoresponse at the NW-Pt contacts. At applied bias, unidirectional photocurrent was observed and higher photocurrent was achieved with localized laser irradiation at reverse-biased NW-Pt contacts. At zero bias, the opposite polarity of photocurrents was detected when the two NW-Pt contacts were subjected to focused laser beam irradiation. A reduced Schottky barrier/width resulting from an increase in charge carriers and thermoelectric effects arising from the localized thermal heating due to focused laser beam irradiation were proposed as the mechanisms dictating the photocurrent at the NW-Pt interface. Comparison of photocurrents generated upon global and localized laser irradiation showed that the main contribution to the photocurrent was largely due to the photoresponse of the NW-Pt contacts.

  7. Global life satisfaction predicts ambulatory affect, stress, and cortisol in daily life in working adults.

    PubMed

    Smyth, Joshua M; Zawadzki, Matthew J; Juth, Vanessa; Sciamanna, Christopher N

    2017-04-01

    Global life satisfaction has been linked with long-term health advantages, yet how life satisfaction impacts the trajectory of long-term health is unclear. This paper examines one such possible mechanism-that greater life satisfaction confers momentary benefits in daily life that accumulate over time. A community sample of working adults (n = 115) completed a measure of life satisfaction and then three subsequent days of ecological momentary assessment surveys (6 times/day) measuring affect (i.e., emotional valence, arousal), and perceived stress, and also provided salivary cortisol samples. Multilevel models indicated that people with higher (vs. lower) levels of life satisfaction reported better momentary affect, less stress, marginally lower momentary levels and significantly altered diurnal slopes of cortisol. Findings suggest individuals with high global life satisfaction have advantageous daily experiences, providing initial evidence for potential mechanisms through which global life satisfaction may help explain long-term health benefits.

  8. Improved entrance optic for global irradiance measurements with a Brewer spectrophotometer.

    PubMed

    Gröbner, Julian

    2003-06-20

    A new entrance optic for a Brewer spectrophotometer has been designed and tested both in the laboratory and during solar measurements. The integrated cosine response deviates by 2.4% from the ideal, with an uncertainty of +/- 1%. The systematic uncertainties of global solar irradiance measurements with this new entrance optic are considerably reduced compared with measurements with the traditional design. Simultaneous solar irradiance measurements between the Brewer spectrophotometer and a spectroradiometer equipped with a state-of-the-art shaped diffuser agreed to within +/- 2% during a five-day measurement period.

  9. Intercomparison of 51 radiometers for determining global horizontal irradiance and direct normal irradiance measurements

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Habte, Aron; Sengupta, Manajit; Andreas, Afshin

    Accurate solar radiation measurements require properly installed and maintained radiometers with calibrations traceable to the World Radiometric Reference. This study analyzes the performance of 51 commercially available and prototype radiometers used for measuring global horizontal irradiances or direct normal irradiances. These include pyranometers, pyrheliometers, rotating shadowband radiometers, and a pyranometer with an internal shading mask deployed at the National Renewable Energy Laboratory's (NREL) Solar Radiation Research Laboratory. The radiometers in this study were deployed for one year (from April 1, 2011, through March 31, 2012), and their measurements were compared under clear-sky, partly cloudy, and mostly cloudy conditions to referencemore » values of low estimated measurement uncertainties. The intent of this paper is to present a general overview of each radiometer's performance based on the instrumentation and environmental conditions available at NREL.« less

  10. The calculated influence of atmospheric conditions on solar cell ISC under direct and global solar irradiances

    NASA Technical Reports Server (NTRS)

    Mueller, Robert L.

    1987-01-01

    Calculations of the influence of atmospheric conditions on solar cell short-circuit current (Isc) are made using a recently developed computer model for solar spectral irradiance distribution. The results isolate the dependence of Isc on changes in the spectral irradiance distribution without the direct influence of the total irradiance level. The calculated direct normal irradiance and percent diffuse irradiance are given as a reference to indicate the expected irradiance levels. This method can be applied to the calibration of photovoltaic reference cells. Graphic examples are provided for amorphous silicon and monocrystalline silicon solar cells under direct normal and global normal solar irradiances.

  11. New method for estimating daily global solar radiation over sloped topography in China

    NASA Astrophysics Data System (ADS)

    Shi, Guoping; Qiu, Xinfa; Zeng, Yan

    2018-03-01

    A new scheme for the estimation of daily global solar radiation over sloped topography in China is developed based on the Iqbal model C and MODIS cloud fraction. The effects of topography are determined using a digital elevation model. The scheme is tested using observations of solar radiation at 98 stations in China, and the results show that the mean absolute bias error is 1.51 MJ m-2 d-1 and the mean relative absolute bias error is 10.57%. Based on calculations using this scheme, the distribution of daily global solar radiation over slopes in China on four days in the middle of each season (15 January, 15 April, 15 July and 15 October 2003) at a spatial resolution of 1 km × 1 km are analyzed. To investigate the effects of topography on global solar radiation, the results determined in four mountains areas (Tianshan, Kunlun Mountains, Qinling, and Nanling) are discussed, and the typical characteristics of solar radiation over sloped surfaces revealed. In general, the new scheme can produce reasonable characteristics of solar radiation distribution at a high spatial resolution in mountain areas, which will be useful in analyses of mountain climate and planning for agricultural production.

  12. The Effect of Improved Sub-Daily Earth Rotation Models on Global GPS Data Processing

    NASA Astrophysics Data System (ADS)

    Yoon, S.; Choi, K. K.

    2017-12-01

    Throughout the various International GNSS Service (IGS) products, strong periodic signals have been observed around the 14 day period. This signal is clearly visible in all IGS time-series such as those related to orbit ephemerides, Earth rotation parameters (ERP) and ground station coordinates. Recent studies show that errors in the sub-daily Earth rotation models are the main factors that induce such noise. Current IGS orbit processing standards adopted the IERS 2010 convention and its sub-daily Earth rotation model. Since the IERS convention had published, recent advances in the VLBI analysis have made contributions to update the sub-daily Earth rotation models. We have compared several proposed sub-daily Earth rotation models and show the effect of using those models on orbit ephemeris, Earth rotation parameters and ground station coordinates generated by the NGS global GPS data processing strategy.

  13. Randomized trial comparing two methods of re-irradiation after salvage surgery in head and neck squamous cell carcinoma: Once daily split-course radiotherapy with concomitant chemotherapy or twice daily radiotherapy with cetuximab.

    PubMed

    Tao, Yungan; Faivre, Laura; Laprie, Anne; Boisselier, Pierre; Ferron, Christophe; Jung, Guy Michel; Racadot, Séverine; Gery, Bernard; Even, Caroline; Breuskin, Ingrid; Bourhis, Jean; Janot, François

    2018-05-18

    A previous randomized trial in recurrent Head and Neck squamous-cell carcinoma (HNSCC) has shown re-irradiation combined with chemotherapy after salvage surgery significantly improved disease-free survival (DFS). The objective of this randomized trial was to compare two methods of re-irradiation in terms of toxicity and survival. Patients with recurrence/second primary in previously irradiated area were randomly allocated to receive either 60 Gy over 11 weeks with concomitant 5FU - hydroxyurea (VP-arm), or 60 Gy (1.2 Gy twice daily) over 5 weeks with cetuximab (HFR-arm). Primary endpoint was treatment interruption >15 days (acute toxicity). Twenty-six patients were included in VP-arm and 27 in HFR-arm. One patient in VP-arm experienced >15 days interruption due to toxicity, and none in HFR-arm. In both arms, all patients received at least 60 Gy. In VP-arm, 8/26 patients had chemotherapy delay and/or dose reduction. In HFR-arm, 4/27 patients had <6 cycles cetuximab. There was no significant difference in overall survival (Median OS: 37.4 months vs 21.9 months, p = 0.12). Toxicities and DFS were not different between 2 arms. Twice daily schedule of re-irradiation of 60 Gy/5 weeks with cetuximab was tolerable and no significant difference in treatment delays occurred between two arms. Copyright © 2018 Elsevier B.V. All rights reserved.

  14. A daily global mesoscale ocean eddy dataset from satellite altimetry.

    PubMed

    Faghmous, James H; Frenger, Ivy; Yao, Yuanshun; Warmka, Robert; Lindell, Aron; Kumar, Vipin

    2015-01-01

    Mesoscale ocean eddies are ubiquitous coherent rotating structures of water with radial scales on the order of 100 kilometers. Eddies play a key role in the transport and mixing of momentum and tracers across the World Ocean. We present a global daily mesoscale ocean eddy dataset that contains ~45 million mesoscale features and 3.3 million eddy trajectories that persist at least two days as identified in the AVISO dataset over a period of 1993-2014. This dataset, along with the open-source eddy identification software, extract eddies with any parameters (minimum size, lifetime, etc.), to study global eddy properties and dynamics, and to empirically estimate the impact eddies have on mass or heat transport. Furthermore, our open-source software may be used to identify mesoscale features in model simulations and compare them to observed features. Finally, this dataset can be used to study the interaction between mesoscale ocean eddies and other components of the Earth System.

  15. A daily global mesoscale ocean eddy dataset from satellite altimetry

    PubMed Central

    Faghmous, James H.; Frenger, Ivy; Yao, Yuanshun; Warmka, Robert; Lindell, Aron; Kumar, Vipin

    2015-01-01

    Mesoscale ocean eddies are ubiquitous coherent rotating structures of water with radial scales on the order of 100 kilometers. Eddies play a key role in the transport and mixing of momentum and tracers across the World Ocean. We present a global daily mesoscale ocean eddy dataset that contains ~45 million mesoscale features and 3.3 million eddy trajectories that persist at least two days as identified in the AVISO dataset over a period of 1993–2014. This dataset, along with the open-source eddy identification software, extract eddies with any parameters (minimum size, lifetime, etc.), to study global eddy properties and dynamics, and to empirically estimate the impact eddies have on mass or heat transport. Furthermore, our open-source software may be used to identify mesoscale features in model simulations and compare them to observed features. Finally, this dataset can be used to study the interaction between mesoscale ocean eddies and other components of the Earth System. PMID:26097744

  16. Estimation of height-dependent solar irradiation and application to the solar climate of Iran

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Samimi, J.

    1994-05-01

    An explicitly height-dependent model has been used to estimate the solar irradiation over Iran which has a vast range of altitudes. The parameters of the model have been chosen on general grounds and not by parameters best fitting to any of the available measured irradiation data in Iran. The estimated global solar irradiation on the horizontal surface shows a very good agreement (4.1% deviation) with the 17-year long pyranometric measurements in Tehran, and also, is in good agreement with other, shorter available measured data. The entire data base of the Iranian meteorological stations have been used to establish a simplemore » relation between the sunshine duration records and the cloud cover reports which can be utilized in solar energy estimations for sites with no sunshine duration recorders. Clear sky maps of Iran for direct solar irradiation on tracking, horizontal, and south-facing vertical planes are presented. The global solar irradiation map for horizontal surface with cloudiness is zoned into four irradiation zones. In about four-fifths of the land in Iran, the annual-mean daily global solar irradiation on horizontal surface ranges from 4.5 to 5.4 kWh/m[sup 2].« less

  17. Directional and Spectral Irradiance in Ocean Models: Effects on Simulated Global Phytoplankton, Nutrients, and Primary Production

    NASA Technical Reports Server (NTRS)

    Gregg, Watson W.; Rousseaux, Cecile S.

    2016-01-01

    The importance of including directional and spectral light in simulations of ocean radiative transfer was investigated using a coupled biogeochemical-circulation-radiative model of the global oceans. The effort focused on phytoplankton abundances, nutrient concentrations and vertically-integrated net primary production. The importance was approached by sequentially removing directional (i.e., direct vs. diffuse) and spectral irradiance and comparing results of the above variables to a fully directionally and spectrally-resolved model. In each case the total irradiance was kept constant; it was only the pathways and spectral nature that were changed. Assuming all irradiance was diffuse had negligible effect on global ocean primary production. Global nitrate and total chlorophyll concentrations declined by about 20% each. The largest changes occurred in the tropics and sub-tropics rather than the high latitudes, where most of the irradiance is already diffuse. Disregarding spectral irradiance had effects that depended upon the choice of attenuation wavelength. The wavelength closest to the spectrally-resolved model, 500 nm, produced lower nitrate (19%) and chlorophyll (8%) and higher primary production (2%) than the spectral model. Phytoplankton relative abundances were very sensitive to the choice of non-spectral wavelength transmittance. The combined effects of neglecting both directional and spectral irradiance exacerbated the differences, despite using attenuation at 500 nm. Global nitrate decreased 33% and chlorophyll decreased 24%. Changes in phytoplankton community structure were considerable, representing a change from chlorophytes to cyanobacteria and coccolithophores. This suggested a shift in community function, from light-limitation to nutrient limitation: lower demands for nutrients from cyanobacteria and coccolithophores favored them over the more nutrient-demanding chlorophytes. Although diatoms have the highest nutrient demands in the model, their

  18. Retrieving atmospheric transmissivity for biologically active daily dose, in various european sites

    NASA Astrophysics Data System (ADS)

    de La Casinière, A.; Touré, M. L.; Lenoble, J.; Cabot, T.

    2003-04-01

    In the frame of the European Project EDUCE, global UV irradiance spectra recorded all along the year in several European sites are stored in a common database located in Finland. From the spectra set of some of these stations, are calculated atmospheric transmissivities for daily doses of four biologically active UV radiation, namely: UV-B, erythema, DNA damage, and plant damage. A transmissivity is defined as the ratio of the ground level value of the daily dose of interest to its corresponding extra-atmospheric value. Multiple linear correlation of the various transmissivities with three predictors (daily sunshine fraction, cosine of the daily minimum SZA, and daily total ozone column) assumed to be independent variables, are done for year 2000. The coefficients obtained from year 2000 correlation in a given site are expected to retrieve, from the local predictors, the daily dose for year 2001 in the same site, the average error being lesser than 10% for monthly mean values, and lesser than 5% for three-monthly mean values, depending on the daily dose type. Comparison of yearly mean daily doses retrieved in a given site from coefficients obtained in other sites is also presented.

  19. Evaluation of the Delta-T SPN1 radiometer for the measurement of solar irradiance components

    NASA Astrophysics Data System (ADS)

    Estelles, Victor; Serrano, David; Segura, Sara; Wood, John; Webb, Nick; Utrillas, Maria Pilar

    2016-04-01

    In this study we analyse the performance of an SPN1 radiometer built by Delta-T Devices Ltd. to retrieve global solar irradiance at ground and its components (diffuse, direct) in comparison with measurements from two Kipp&Zonen CMP21 radiometers and a Kipp&Zonen CHP1 pirheliometer, mounted on an active Solys-2 suntracker at the Burjassot site (Valencia, Spain) using data acquired every minute during years 2013 - 2015. The measurement site is close to sea level (60 m a.s.l.), near the Mediterranean coast (10 km) and within the metropolitan area of Valencia City (over 1.500.000 inhabitants). The SPN1 is an inexpensive and versatile instrument for the measurement of the three components of the solar radiation without any mobile part and without any need to azimuthally align the instrument to track the sun (http://www.delta-t.co.uk). The three components of the solar radiation are estimated from a combination of measurements performed by 7 different miniature thermopiles. The SPN1 pyranometer measures the irradiance between 400 and 2700 nm, and the nominal uncertainty for the individual readings is about 8% ± 10 W/m2 (5% for the daily averages). The pyranometer Kipp&Zonen CMP21 model is a secondary standard for the measurement of broadband solar global irradiance in horizontal planes. Two ventilated CMP21 are used for the measurement of the global and diffuse irradiances. The expected total daily uncertainty of the radiometer is estimated to be 2%. The pirheliometer Kipp&Zonen CHP1 is designed for the measurement of the direct irradiance. The principles are similar to the CMP21 pyranometer. The results of the comparison show that the global irradiance from the SPN1 compares very well with the CMP21, with absolute RMSD and MBD differences below the combined uncertainties (15 W/m2 and -5.4 W/m2, respectively; relative RMSD of 3.1%). Both datasets are very well correlated, with a correlation coefficient higher than 0.997 and a slope and intercept very close to 1 and 0

  20. AMINO ACIDURIA IN PRIMATES FOLLOWING IRRADIATION

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hunter, C.G.

    The daily urine amino N excretion of 4 monkeys was followed before and after whole body irradiation with doses in the lower lethal range. In 2 non- survivors, there was little change in the daily quantity excreted until terminally. In 2 survivors given the same food intakes as in the irradiated study and sham irradiated, the daily urine amino N excretion during the first week differed but slightly from the values after irradiation, but in the second week more amino N was excreted after irradiation in one animal and less in the other. It would appear that amino aciduria inmore » primates irradiated with doses in the lower lethal range is inseparable from the natural response of the over-all protein metabolism associated with any injury. (auth)« less

  1. Fundamental statistical relationships between monthly and daily meteorological variables: Temporal downscaling of weather based on a global observational dataset

    NASA Astrophysics Data System (ADS)

    Sommer, Philipp; Kaplan, Jed

    2016-04-01

    Accurate modelling of large-scale vegetation dynamics, hydrology, and other environmental processes requires meteorological forcing on daily timescales. While meteorological data with high temporal resolution is becoming increasingly available, simulations for the future or distant past are limited by lack of data and poor performance of climate models, e.g., in simulating daily precipitation. To overcome these limitations, we may temporally downscale monthly summary data to a daily time step using a weather generator. Parameterization of such statistical models has traditionally been based on a limited number of observations. Recent developments in the archiving, distribution, and analysis of "big data" datasets provide new opportunities for the parameterization of a temporal downscaling model that is applicable over a wide range of climates. Here we parameterize a WGEN-type weather generator using more than 50 million individual daily meteorological observations, from over 10'000 stations covering all continents, based on the Global Historical Climatology Network (GHCN) and Synoptic Cloud Reports (EECRA) databases. Using the resulting "universal" parameterization and driven by monthly summaries, we downscale mean temperature (minimum and maximum), cloud cover, and total precipitation, to daily estimates. We apply a hybrid gamma-generalized Pareto distribution to calculate daily precipitation amounts, which overcomes much of the inability of earlier weather generators to simulate high amounts of daily precipitation. Our globally parameterized weather generator has numerous applications, including vegetation and crop modelling for paleoenvironmental studies.

  2. Two global data sets of daily fire emission injection heights since 2003

    NASA Astrophysics Data System (ADS)

    Rémy, Samuel; Veira, Andreas; Paugam, Ronan; Sofiev, Mikhail; Kaiser, Johannes W.; Marenco, Franco; Burton, Sharon P.; Benedetti, Angela; Engelen, Richard J.; Ferrare, Richard; Hair, Jonathan W.

    2017-02-01

    The Global Fire Assimilation System (GFAS) assimilates fire radiative power (FRP) observations from satellite-based sensors to produce daily estimates of biomass burning emissions. It has been extended to include information about injection heights derived from fire observations and meteorological information from the operational weather forecasts of ECMWF. Injection heights are provided by two distinct methods: the Integrated Monitoring and Modelling System for wildland fires (IS4FIRES) parameterisation and the one-dimensional plume rise model (PRM). A global database of daily biomass burning emissions and injection heights at 0.1° resolution has been produced for 2003-2015 and is continuously extended in near-real time with the operational GFAS service of the Copernicus Atmospheric Monitoring Service (CAMS). In this study, the two injection height data sets were compared with the new MPHP2 (MISR Plume Height Project 2) satellite-based plume height retrievals. The IS4FIRES parameterisation showed a better overall agreement than the observations, while the PRM was better at capturing the variability of injection heights. The performance of both parameterisations is also dependent on the type of vegetation. Furthermore, the use of biomass burning emission heights from GFAS in atmospheric composition forecasts was assessed in two case studies: the South AMerican Biomass Burning Analysis (SAMBBA) campaign which took place in September 2012 in Brazil, and a series of large fire events in the western USA in August 2013. For these case studies, forecasts of biomass burning aerosol species by the Composition Integrated Forecasting System (C-IFS) of CAMS were found to better reproduce the observed vertical distribution when using PRM injection heights from GFAS compared to aerosols emissions being prescribed at the surface. The globally available GFAS injection heights introduced and evaluated in this study provide a comprehensive data set for future fire and atmospheric

  3. Validation and Development of the GPCP Experimental One-Degree Daily (1DD) Global Precipitation Product

    NASA Technical Reports Server (NTRS)

    Huffman, George J.; Adler, Robert F.; Bolvin, David T.; Einaud, Franco (Technical Monitor)

    2000-01-01

    The One-Degree Daily (1DD) precipitation dataset has been developed for the Global Precipitation Climatology Project (GPCP) and is currently in beta test preparatory to release as an official GPCP product. The 1DD provides a globally-complete, observation-only estimate of precipitation on a daily 1 deg. x 1 deg. grid for the period 1997 through early 2000 (by the time of the conference). In the latitude band 40N-40S the 1DD uses the Threshold-Matched Precipitation Index (TMPI), a GPI-like IR product with the pixel-level T(sub b) threshold and (single) conditional rain rate determined locally for each month by the frequency of precipitation in the GPROF SSM/I product and by, the precipitation amount in the GPCP monthly satellite-gauge (SG) combination. Outside 40N-40S the 1DD uses a scaled TOVS precipitation estimate that has month-by-month adjustments based on the TMPI and the SG. Early validation results are encouraging. The 1DD shows relatively large scatter about the daily validation values in individual grid boxes, as expected for a technique that depends on cloud-sensing schemes such as the TMPI and TOVS. On the other hand, the time series of 1DD shows good correlation with validation in individual boxes. For example, the 1997-1998 time series of 1DD and Oklahoma Mesonet values in a grid box in northeastern Oklahoma have the correlation coefficient = 0.73. Looking more carefully at these two time series, the number of raining days for the 1DD is within 7% of the Mesonet value, while the distribution of daily rain values is very similar. Other tests indicate that area- or time-averaging improve the error characteristics, making the data set highly attractive to users interested in stream flow, short-term regional climatology, and model comparisons. The second generation of the 1DD product is currently under development; it is designed to directly incorporate TRMM and other high-quality precipitation estimates. These data are generally sparse because they are

  4. A technique for global monitoring of net solar irradiance at the ocean surface. I - Model

    NASA Technical Reports Server (NTRS)

    Frouin, Robert; Chertock, Beth

    1992-01-01

    An accurate long-term (84-month) climatology of net surface solar irradiance over the global oceans from Nimbus-7 earth radiation budget (ERB) wide-field-of-view planetary-albedo data is generated via an algorithm based on radiative transfer theory. Net surface solar irradiance is computed as the difference between the top-of-atmosphere incident solar irradiance (known) and the sum of the solar irradiance reflected back to space by the earth-atmosphere system (observed) and the solar irradiance absorbed by atmospheric constituents (modeled). It is shown that the effects of clouds and clear-atmosphere constituents can be decoupled on a monthly time scale, which makes it possible to directly apply the algorithm with monthly averages of ERB planetary-albedo data. Compared theoretically with the algorithm of Gautier et al. (1980), the present algorithm yields higher solar irradiance values in clear and thin cloud conditions and lower values in thick cloud conditions.

  5. A reconstruction of solar irradiance using a flux transport model

    NASA Astrophysics Data System (ADS)

    Dasi Espuig, Maria; Krivova, Natalie; Solanki, Sami K.; Jiang, Jie

    2012-07-01

    Solar irradiance is one of the important drivers of the Earth's global climate, but it has only been measured for the past 33 years. Its reconstructions are therefore crucial to study longer term variations relevant to climate timescales. Most successful in reproducing the measured irradiance variations have being the models that are based on the assumption that irradiance changes are caused by the evolution of the photospheric magnetic field. Our SATIRE-S model is one of these, which uses solar full-disc magnetograms as an input, and these are available for less than four decades. To reconstruct the irradiance back to times when no observed magnetograms are available, we combine the SATIRE-S model with synthetic magnetograms, produced using a surface flux transport model. The model is fed with daily, observed or modelled statistically, records of sunspot positions, areas, and tilt angles. The concept of overlapping ephemeral region cycles is used to describe the secular change in the irradiance.

  6. Reconstruction of erythemal UV irradiance at Hohenpeissenberg (1968-2001) considering trends of total ozone, cloudiness, and turbidity

    NASA Astrophysics Data System (ADS)

    Trepte, S.; Winkler, P.

    2003-04-01

    The global mean total column ozone amount for the period 1997-2001 was approximately 3% below the 1964-1980 average. The largest ozone decreases in the northern hemisphere midlatitudes are observed during winter-spring (˜4%), with summer-autumn decreases approximately half as large. Total ozone measured at Hohenpeissenberg, Germany (48^oN, 11^oE) shows a strong decrease by about 10% since 1968, representing the long-term downward trend over Central Europe. The main consequence of this phenomenon is the expected increase of solar ultraviolet irradiation (UV-B) reaching the Earth's surface with the known harmful effects on the biosphere. Global data records of reliable routine observations of UV irradiance are still too short for accurate estimation of long-term UV variations and trends. While direct UV mesaurements at Hohenpeissenberg are available only since 1990, the long-term development of UV-B have to be reconstructed. Besides on the amount of total ozone the UV irradiation at the ground depends also on atmospheric turbidity and cloudiness. The reconstruction method is based on statistical correlations of measured UV-B data with the influencing parameters total ozone, turbidity and cloud modification factors derived from eye-observations in connection with total solar irradiance data. These observed data allow a realistic reconstruction of the UV-B time series, since no assumption on these influencing data have to be made. A model is presented, using hourly observed spectral UV-B irradiance (1990-1998), total solar irradiance, total ozone amount (daily mean) and clouds to derive erythemal UV irradiance and daily doses at Hohenpeissenberg in the period 1968-2001. A comparison with recorded UV data shows good agreement. Due to long-term total ozone loss, peak values of erythemal UV irradiance in spring and summer at clear-sky conditions have strongly increased (+4.2%/decade in June). Mean daily doses have also increased in this season (+5.4%/decade in May) but

  7. Empirical evaluation of global vitamin D effective ultraviolet irradiances under cloudy conditions for a subtropical southern hemisphere site.

    PubMed

    Turnbull, David J; Parisi, Alfio V; Schouten, Peter W

    2010-05-01

    This paper evaluates the global vitamin D effective UV (UV(vitd)) irradiances under cloudy conditions at a subtropical, southern hemisphere site. The UV(vitd) irradiances were analyzed on a horizontal plane and sampled at 5-min intervals over 18 months so that a wide range of parameters including cloud conditions, solar zenith angles (SZA) and ozone levels were taken into account. Cloud modification factors were determined from the influence of clouds on the global broadband solar radiation, and these were applied to the cloud-free vitamin D effective UV irradiance to evaluate the UV(vitd) irradiances on a horizontal plane for cloudy conditions. For vitamin D effective UV irradiance, cloud modification factors were found to range from 0.9 to 1.0 for no cloud and 0.4 to 0.5 for 8 octa of cloud cover. SZA played a minimal role in this variation. A comparison of the measured and calculated UV(vitd) irradiances for the 2004 data set in the range of SZA of 70 degrees or less provided an R(2) value of 0.90. The output of the model was compared to data measured during the first 6 months of 2005 for an SZA of 70 degrees or less and provided an R(2) value of approximately 0.82.

  8. Global horizontal irradiance clear sky models : implementation and analysis.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Stein, Joshua S.; Hansen, Clifford W.; Reno, Matthew J.

    2012-03-01

    Clear sky models estimate the terrestrial solar radiation under a cloudless sky as a function of the solar elevation angle, site altitude, aerosol concentration, water vapor, and various atmospheric conditions. This report provides an overview of a number of global horizontal irradiance (GHI) clear sky models from very simple to complex. Validation of clear-sky models requires comparison of model results to measured irradiance during clear-sky periods. To facilitate validation, we present a new algorithm for automatically identifying clear-sky periods in a time series of GHI measurements. We evaluate the performance of selected clear-sky models using measured data from 30 differentmore » sites, totaling about 300 site-years of data. We analyze the variation of these errors across time and location. In terms of error averaged over all locations and times, we found that complex models that correctly account for all the atmospheric parameters are slightly more accurate than other models, but, primarily at low elevations, comparable accuracy can be obtained from some simpler models. However, simpler models often exhibit errors that vary with time of day and season, whereas the errors for complex models vary less over time.« less

  9. MARs Color Imager (MARCI) Daily Global Ozone Column Mapping from the Mars Reconnaissance Orbiter (MRO): A Survey of 2006-2010 Results

    NASA Astrophysics Data System (ADS)

    Clancy, R. T.; Wolff, M. J.; Malin, M. C.; Cantor, B. A.

    2010-12-01

    MARCI UV band imaging photometry within (260nm) and outside (320nm) the Hartley ozone band absorption supports daily global mapping of Mars ozone column abundances. Key retrieval issues include accurate UV radiometric calibrations, detailed specifications of surface and atmospheric background reflectance (surface albedo, atmospheric Raleigh and dust scattering/absorption), and simultaneous cloud retrievals. The implementation of accurate radiative transfer (RT) treatments of these processes has been accomplished (Wolff et al., 2010) such that daily global mapping retrievals for Mars ozone columns have been completed for the 2006-2010 period of MARCI global imaging. Ozone retrievals are most accurate for high column abundances associated with mid-to-high latitude regions during fall, winter, and spring seasons. We present a survey of these MARCI ozone column retrievals versus season, latitude, longitude, and year.

  10. Retrieving vertical ozone profiles from measurements of global spectral irradiance

    NASA Astrophysics Data System (ADS)

    Bernhard, Germar; Petropavlovskikh, Irina; Mayer, Bernhard

    2017-12-01

    A new method is presented to determine vertical ozone profiles from measurements of spectral global (direct Sun plus upper hemisphere) irradiance in the ultraviolet. The method is similar to the widely used Umkehr technique, which inverts measurements of zenith sky radiance. The procedure was applied to measurements of a high-resolution spectroradiometer installed near the centre of the Greenland ice sheet. Retrieved profiles were validated with balloon-sonde observations and ozone profiles from the space-borne Microwave Limb Sounder (MLS). Depending on altitude, the bias between retrieval results presented in this paper and MLS observations ranges between -5 and +3 %. The magnitude of this bias is comparable, if not smaller, to values reported in the literature for the standard Dobson Umkehr method. Total ozone columns (TOCs) calculated from the retrieved profiles agree to within 0.7±2.0 % (±1σ) with TOCs measured by the Ozone Monitoring Instrument on board the Aura satellite. The new method is called the Global-Umkehr method.

  11. Solutions Network Formulation Report. Aerosol Polarimetry Sensor Measurements of Diffuse-to-Global Irradiance Ratio for Improved Forecasting of Plant Productivity and Health

    NASA Technical Reports Server (NTRS)

    Knowlton, Kelly; Andrews, Jane C.; Ryan, Robert E.

    2007-01-01

    Studies have shown that vegetation is directly sensitive to changes in the diffuse-to-global irradiance ratio and that increased percentage of diffuse irradiation can accelerate photosynthesis. Therefore, measurements of diffuse versus global irradiance could be useful for monitoring crop productivity and overall vegetative health as they relate to the total amount of particulates in the air that result from natural disasters or anthropogenic (manmade) causes. While the components of solar irradiance are measured by satellite and surface sensors and calculated with atmospheric models, disagreement exists between the results, creating a need for more accurate and comprehensive retrievals of atmospheric aerosol parameters. Two satellite sensors--APS and VIIRS--show promise for retrieving aerosol properties at an unprecedented level of accuracy. APS is expected to be launched in December 2008. The planned launch date for VIIRS onboard NPP is September 2009. Identified partners include the USDA s ARS, North Carolina State University, Purdue Climate Change Research Center, and the Cooperative Institute for Research in the Atmosphere at Colorado State University. Although at present no formal DSSs (decision support systems) require accurate values of diffuse-to-global irradiance, this parameter is sufficiently important that models are being developed that will incorporate these measurements. This candidate solution is aligned with the Agricultural Efficiency and Air Quality National Applications.

  12. A comparison between one year of daily global irradiation from ground-based measurements versus meteosat images from seven locations in Tunisia

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Djemaa, A.B.; Delorme, C.

    1992-01-01

    Three numerical images from METEOSAT B2 per day have been processed over a period of 12 months, from October 1985 to September 1986, to estimate the daily values of available solar radiation in Tunisia. The methodology used, GISTEL, on the images of the visible' channel of METEOSAT, is described. Results are compared with measured radiation values from seven stations of the Institut de la Meteorologie de Tunisie.' Among more than 2,200 measured-estimated daily pairs, a high percentage, 89%, show a relative error of + or {minus}10%. Many figures concerning Sidi-Bou-Said, Kairouan, Thala, and Gafsa are presented to show the capabilitymore » of GISTEL to map the daily available solar radiation with a sufficient spatial resolution in countries where radiation measurements are too scarce.« less

  13. Quantitative Assessment of the Integrated Response in Global Heat and Moisture Budgets to Changing Solar Irradiance

    NASA Technical Reports Server (NTRS)

    White, Warren B.; Cayan, Daniel R.; Dettinger, Michael; Sharber, James (Technical Monitor)

    2001-01-01

    Earlier, we found time sequences of basin- and global-average upper ocean temperature (that is, diabatic heat storage above the main pycnocline) for 40 years from 1955-1994 and of sea surface temperature for 95 years from 1900-1994 associated with changes in the Sun's radiative forcing on decadal and interdecadal timescales, lagging by 10 deg.- 30 deg. of phase and confined to the upper 60-120 m. Yet, the observed changes in upper ocean temperature (approx. 0.1 K) were approximately twice those expected from the Stefan-Boltzmann black-body radiation law for the Earth's surface, with phase lags (0 deg. to 30 deg. of phase) much shorter than the 90 deg. phase shift expected as well. Moreover, White et al. (1997, 1998) found the Earth's global decadal mode in covarying SST and SLP anomalies phase locked to the decadal signal in the Sun's irradiance. Yet, Allan (2000) found this decadal signal also characterized by patterns similar to those observed on biennial and interannual time scales; that is, the Troposphere Biennial Oscillation (TBO) and the El Nino and the Southern Oscillation (ENSO). This suggested that small changes in the Sun's total irradiance could excite this global decadal mode in the Earth's ocean-atmosphere-terrestrial system similar to those excited internally on biennial and interannual period scales. This is a significant finding, proving that energy budget models (that is, models based on globally-averaged radiation balances) yield unrealistic responses. Thus, the true response must include positive and negative feedbacks in the Earth's ocean-atmosphere-terrestrial system as its internal mode (that is, the natural mode of the system) respond in damped resonance to quasi-periodic decadal changes in the Sun's irradiance. Moreover, these responses are not much different from those occurring internally on biennial and interannual period scales.

  14. 33 Years of Near-Global Daily Precipitation from Multisatellite Observations and its Application to Drought Monitoring

    NASA Astrophysics Data System (ADS)

    Ashouri, H.; Hsu, K.; Sorooshian, S.; Braithwaite, D.; Knapp, K. R.; Cecil, L. D.

    2013-12-01

    PERSIANN Climate Data Record (PERSIANN-CDR) is a new retrospective satellite-based precipitation data set that is constructed for long-term hydrological and climate studies. The PERSIANN-CDR is a near-global (60°S-60°N) long-term (1980-2012), multi-satellite, high-resolution precipitation product that provides rain rate estimates at 0.25° and daily spatiotemporal resolution. PERSIANN-CDR is aimed at addressing the need for a consistent, long-term, high resolution precipitation data set for studying the spatial and temporal variations and changes of precipitation patterns, particularly in a scale relevant to climate extremes at the global scale. PERSIANN-CDR is generated from the PERSIANN algorithm using GridSat-B1 infrared data from the International Satellite Cloud Climatology Project (ISCCP). PERSIANN-CDR is adjusted using the Global Precipitation Climatology Project (GPCP) monthly precipitation to maintain consistency of two data sets at 2.5° monthly scale throughout the entire reconstruction period. PERSIANN-CDR daily precipitation data demonstrates considerable consistency with both GPCP monthly and GPCP 1DD precipitation products. Verification studies over Hurricane Katrina show that PERSIANN-CDR has a good agreement with NCEP Stage IV radar data, noting that PERSIANN-CDR has better spatial coverage. In addition, the Probability Density Function (PDF) of PERSIANN-CDR over the contiguous United States was compared with the PDFs extracted from CPC gauge data and the TMPA precipitation product. The experiment also shows good agreement of the PDF of PERSIANN-CDR with the PDFs of TMPA and CPC gauge data. The application of PERSIANN-CDR in regional and global drought monitoring is investigated. Consisting of more than three decades of high-resolution precipitation data, PERSIANN-CDR makes us capable of long-term assessment of droughts at a higher resolution (0.25°) than previously possible. The results will be presented at the meeting.

  15. Long-term global temperature variations under total solar irradiance, cosmic rays, and volcanic activity.

    PubMed

    Biktash, Lilia

    2017-07-01

    The effects of total solar irradiance (TSI) and volcanic activity on long-term global temperature variations during solar cycles 19-23 were studied. It was shown that a large proportion of climate variations can be explained by the mechanism of action of TSI and cosmic rays (CRs) on the state of the lower atmosphere and other meteorological parameters. The role of volcanic signals in the 11-year variations of the Earth's climate can be expressed as several years of global temperature drop. Conversely, it was shown that the effects of solar, geophysical, and human activity on climate change interact. It was concluded that more detailed investigations of these very complicated relationships are required, in order to be able to understand issues that affect ecosystems on a global scale.

  16. Using Global Total Electron Content to Understand Interminimum Changes in Solar EUV Irradiance and Thermospheric Composition

    NASA Astrophysics Data System (ADS)

    McDonald, S. E.; Emmert, J. T.; Krall, J.; Mannucci, A. J.; Vergados, P.

    2017-12-01

    To understand how and why the distribution of geospace plasma in the ionosphere/plasmasphere is evolving over multi-decadal time scales in response to solar, heliospheric and atmospheric forcing, it is critically important to have long-term, stable datasets. In this study, we use a newly constructed dataset of GPS-based total electron content (TEC) developed by JPL. The JPL Global Ionosphere Mapping (GIM) algorithm was used to generate a 35-station dataset spanning two solar minimum periods (1993-2014). We also use altimeter-derived TEC measurements from TOPEX-Poseidon and Jason-1 to construct a continuous dataset for the 1995-2014 time period. Both longterm datasets are compared to each other to study interminimum changes in the global TEC (during 1995-1995 and 2008-2009). We use the SAMI3 physics-based model of the ionosphere to compare the simulations of 1995-2014 with the JPL TEC and TOPEX/Jason-1 datasets. To drive SAMI3, we use the Naval Research Laboratory Solar Spectral Irradiance (NRLSSI) model to specify the EUV irradiances, and NRLMSIS to specify the thermosphere. We adjust the EUV irradiances and thermospheric constituents to match the TEC datasets and draw conclusions regarding sources of the differences between the two solar minimum periods.

  17. Deployment and early results from the CanSIM (Canadian Solar Spectral Irradiance Meter) network

    NASA Astrophysics Data System (ADS)

    Tatsiankou, Viktar; Hinzer, Karin; Schriemer, Henry; McVey-White, Patrick; Beal, Richard

    2017-09-01

    Three of seven stations have been deployed as part of the Canadian Solar Spectral Irradiance (CanSIM) network situated in Ottawa, Varennes and Egbert to measure long term spectral variation of the direct normal (DNI) and global horizontal irradiances (GHI) across the country. Every station is equipped with a solar tracker, SolarSIM-D2+, SolarSIM-G+, and SR20 pyranometer, reporting the spectral DNI, GHI, diffuse horizontal irradiance (DHI) and aerosol optical depth in the 280-4000 nm range, broadband DNI, GHI, and DHI, atmospheric total column ozone and water vapour amounts. The spectral GHI as measured by the SolarSIM-G+ was within 5% as compared to EKO MS-700 spectroradiometer in 350-1050 nm range on 17 March 2017. The difference in the GHI as reported by SolarSIM-G+ and SR20 pyranometer from all stations was within 2% on 14 April 2017. Furthermore, on this day, the daily GHI sum for the Ottawa, Varennes, and Egbert stations was 7.01, 6.95, and 7.11 kWh/m2, respectively, while the daily DNI sum was 10.65, 10.86, 10.04 kWh/m2, respectively.

  18. A technique for global monitoring of net solar irradiance at the ocean surface. II - Validation

    NASA Technical Reports Server (NTRS)

    Chertock, Beth; Frouin, Robert; Gautier, Catherine

    1992-01-01

    The generation and validation of the first satellite-based long-term record of surface solar irradiance over the global oceans are addressed. The record is generated using Nimbus-7 earth radiation budget (ERB) wide-field-of-view plentary-albedo data as input to a numerical algorithm designed and implemented based on radiative transfer theory. The mean monthly values of net surface solar irradiance are computed on a 9-deg latitude-longitude spatial grid for November 1978-October 1985. The new data set is validated in comparisons with short-term, regional, high-resolution, satellite-based records. The ERB-based values of net surface solar irradiance are compared with corresponding values based on radiance measurements taken by the Visible-Infrared Spin Scan Radiometer aboard GOES series satellites. Errors in the new data set are estimated to lie between 10 and 20 W/sq m on monthly time scales.

  19. Optimal Normal Tissue Sparing in Craniospinal Axis Irradiation Using IMRT With Daily Intrafractionally Modulated Junction(s)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kusters, Johannes M.A.M.; Louwe, Rob J.W.; Kollenburg, Peter G.M. van

    2011-12-01

    Purpose: To develop a treatment technique for craniospinal irradiation using intensity-modulated radiotherapy (IMRT) with improved dose homogeneity at the field junction(s), increased target volume conformity, and minimized dose to the organs at risk (OARs). Methods and Materials: Five patients with high-risk medulloblastoma underwent CT simulation in supine position. For each patient, an IMRT plan with daily intrafractionally modulated junction(s) was generated, as well as a treatment plan based on conventional three-dimensional planning (3DCRT). A dose of 39.6 Gy in 22 daily fractions of 1.8 Gy was prescribed. Dose-volume parameters for target volumes and OARs were compared for the two techniques.more » Results: The maximum dose with IMRT was <107% in all patients. V{sub <95} and V{sub >107} were <1 cm{sup 3} for IMRT compared with 3-9 cm{sup 3} for the craniospinal and 26-43 cm{sup 3} for the spinal-spinal junction with 3DCRT. These observations corresponded with a lower homogeneity index and a higher conformity index for the spinal planning target volume with IMRT. IMRT provided considerable sparing of acute and late reacting tissues. V{sub 75} for the esophagus, gastroesophageal junction, and intestine was 81%, 81%, and 22% with 3DCRT versus 5%, 0%, and 1% with IMRT, respectively. V{sub 75} for the heart and thyroid was 42% and 32% vs. 0% with IMRT. Conclusion: IMRT with daily intrafractionally modulated junction results in a superior target coverage and junction homogeneity compared with 3DCRT. A significant dose reduction can be obtained for acute as well as late-reacting tissues.« less

  20. The potential of different artificial neural network (ANN) techniques in daily global solar radiation modeling based on meteorological data

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Behrang, M.A.; Assareh, E.; Ghanbarzadeh, A.

    2010-08-15

    The main objective of present study is to predict daily global solar radiation (GSR) on a horizontal surface, based on meteorological variables, using different artificial neural network (ANN) techniques. Daily mean air temperature, relative humidity, sunshine hours, evaporation, and wind speed values between 2002 and 2006 for Dezful city in Iran (32 16'N, 48 25'E), are used in this study. In order to consider the effect of each meteorological variable on daily GSR prediction, six following combinations of input variables are considered: (I)Day of the year, daily mean air temperature and relative humidity as inputs and daily GSR as output.more » (II)Day of the year, daily mean air temperature and sunshine hours as inputs and daily GSR as output. (III)Day of the year, daily mean air temperature, relative humidity and sunshine hours as inputs and daily GSR as output. (IV)Day of the year, daily mean air temperature, relative humidity, sunshine hours and evaporation as inputs and daily GSR as output. (V)Day of the year, daily mean air temperature, relative humidity, sunshine hours and wind speed as inputs and daily GSR as output. (VI)Day of the year, daily mean air temperature, relative humidity, sunshine hours, evaporation and wind speed as inputs and daily GSR as output. Multi-layer perceptron (MLP) and radial basis function (RBF) neural networks are applied for daily GSR modeling based on six proposed combinations. The measured data between 2002 and 2005 are used to train the neural networks while the data for 214 days from 2006 are used as testing data. The comparison of obtained results from ANNs and different conventional GSR prediction (CGSRP) models shows very good improvements (i.e. the predicted values of best ANN model (MLP-V) has a mean absolute percentage error (MAPE) about 5.21% versus 10.02% for best CGSRP model (CGSRP 5)). (author)« less

  1. Sensitivity of Daily Doses of Biologically Active Radiation, To Ozone Changes In Southern French Alps

    NASA Astrophysics Data System (ADS)

    de La Casinière, A.; Touré, M. L.; Masserot, D.; Lenoble, J.; Cabot, T.; Pinedo Vega, J. L.

    Global UV irradiance spectra we re recorded each half an hour between sunrise and sunset, along the year 2000 in Briançon (1300m asl) at the CEMBREU (Centre Européen Médical Bioclimatique de Recherche et d'Enseignement Universitaire), a site of the French spectral UV network in Southern Alps. From these spectra are retrieved atmospheric transmissivities corresponding to daily doses of various biologically active radiation. A transmissivity is defined as the ratio of the ground level value of a daily dose to the extra -atmospheric value of this daily dose. The daily doses studied relate to UVB, erythema, DNA damage, and plant damage. Multiple linear correlations of the various transmissivities with the three predictors (daily sunshine fraction), µmin (cosine of the daily minimum SZA), and (daily total ozone column) assumed to be independent variables, are done for year 2000. These correlations permit to assess the mean sensitivities of the various transmissivities, to changes in for different cloud cover conditions in Briançon. The variations of each sensitivity is studied as a function of , µmin and . Comparing the results obtained with those given in the literature, we find for = 1 (that is for a strong probability of clear sky conditions) and SZA min = 45°, a radiation amplification factor (RAF) of the erythemal daily dose equal to 1.1 when = 285 DU, and to 1.4 when = 315 DU.

  2. An unsupervised method for estimating the global horizontal irradiance from photovoltaic power measurements

    NASA Astrophysics Data System (ADS)

    Nespoli, Lorenzo; Medici, Vasco

    2017-12-01

    In this paper, we present a method to determine the global horizontal irradiance (GHI) from the power measurements of one or more PV systems, located in the same neighborhood. The method is completely unsupervised and is based on a physical model of a PV plant. The precise assessment of solar irradiance is pivotal for the forecast of the electric power generated by photovoltaic (PV) plants. However, on-ground measurements are expensive and are generally not performed for small and medium-sized PV plants. Satellite-based services represent a valid alternative to on site measurements, but their space-time resolution is limited. Results from two case studies located in Switzerland are presented. The performance of the proposed method at assessing GHI is compared with that of free and commercial satellite services. Our results show that the presented method is generally better than satellite-based services, especially at high temporal resolutions.

  3. The Global Streamflow Indices and Metadata Archive (GSIM) - Part 1: The production of a daily streamflow archive and metadata

    NASA Astrophysics Data System (ADS)

    Do, Hong Xuan; Gudmundsson, Lukas; Leonard, Michael; Westra, Seth

    2018-04-01

    This is the first part of a two-paper series presenting the Global Streamflow Indices and Metadata archive (GSIM), a worldwide collection of metadata and indices derived from more than 35 000 daily streamflow time series. This paper focuses on the compilation of the daily streamflow time series based on 12 free-to-access streamflow databases (seven national databases and five international collections). It also describes the development of three metadata products (freely available at https://doi.pangaea.de/10.1594/PANGAEA.887477): (1) a GSIM catalogue collating basic metadata associated with each time series, (2) catchment boundaries for the contributing area of each gauge, and (3) catchment metadata extracted from 12 gridded global data products representing essential properties such as land cover type, soil type, and climate and topographic characteristics. The quality of the delineated catchment boundary is also made available and should be consulted in GSIM application. The second paper in the series then explores production and analysis of streamflow indices. Having collated an unprecedented number of stations and associated metadata, GSIM can be used to advance large-scale hydrological research and improve understanding of the global water cycle.

  4. Mars Daily Global Image from April 1999

    NASA Image and Video Library

    2000-09-08

    Twelve orbits a day provide NASA Mars Global Surveyor MOC wide angle cameras a global napshot of weather patterns across the planet. Here, bluish-white water ice clouds hang above the Tharsis volcanoes.

  5. Global surface mass time variations by using a two-step inversion for cumulating daily satellite gravity information

    NASA Astrophysics Data System (ADS)

    Ramillien, Guillaume; Frappart, Frappart; Seoane, Lucia

    2015-04-01

    We propose a new method to produce time series of global maps of surface mass variations by progressive integration of daily geopotential variations measured by orbiting satellites. In the case of the GRACE mission (2002 - 2012), these geopotential variations can be determined from very accurate inter-satellite K-Band Range Rate (KBRR) measurements of 5-second daily orbits. In particular, the along-track gravity contribution of hydrology is extracted by removing de-aliasing models for static field, atmosphere, oceans mass variations (including periodical tides), as well as polar movements. Our determination of surface mass sources consists of two successive dependent Kalman filter stages. The first one consists of reducing the satellite-based potential anomalies by adjusting the longest spatial wavelengths (i.e., low-degree spherical harmonics less than 5-6). In the second stage, the residual potential anomalies from the previous stage are used to recover surface mass density changes - in terms of Equivalent-Water Height (EWH) - over a global network of juxtaposed triangular elements. These surface tiles of ~40,000 km x km are imposed to be identical and homogeneously-distributed over the terrestrial sphere, however they can be adapted to the local geometry of the surface mass. Our global approach was tested by inverting simulated hydrology-related geopotential data, and successfully applied to estimate time-varying surface mass densities from real GRACE-based residuals. This strategy of combined Kalman filter-type inversions can also be useful for exploring the possibility of reaching better time and space resolutions for hydrology, that would be hopefully brought by future low altitude geodetic missions.

  6. Control of continuous irradiation injury on potatoes with daily temperature cycling

    NASA Technical Reports Server (NTRS)

    Tibbitts, T. W.; Bennett, S. M.; Cao, W.

    1990-01-01

    Two controlled-environment experiments were conducted to determine the effects of temperature fluctuations under continuous irradiation on growth and tuberization of two potato (Solanum tuberosum L.) cultivars, Kennebec and Superior. These cultivars had exhibited chlorotic and stunted growth under continuous irradiation and constant temperatures. The plants were grown for 4 weeks in the first experiment and for 6 weeks in the second experiment. Each experiment was conducted under continuous irradiation of 400 micromoles per square meter per second of photosynthetic photon flux and included two temperature treatments: constant 18 degrees C and fluctuating 22 degrees C/14 degrees C on a 12-hour cycle. A common vapor pressure deficit of 0.62 kilopascal was maintained at all temperatures. Plants under constant 18 degrees C were stunted and had chlorotic and abscised leaves and essentially no tuber formation. Plants grown under the fluctuating temperature treatment developed normally, were developing tubers, and had a fivefold or greater total dry weight as compared with those under the constant temperature. These results suggest that a thermoperiod can allow normal plant growth and tuberization in potato cultivars that are unable to develop effectively under continuous irradiation.

  7. Daily Global Mapping of Mars Ozone Column Abundances with MARCI UV Band Imaging

    NASA Technical Reports Server (NTRS)

    Clancy, R. Todd; Wolff, Michael J.; Lefevre, Franck; Cantor, Bruce A.; Malin, Michael C.; Smith, Michael D.

    2015-01-01

    Since November of 2006, The Mars Color Imager (MARCI) onboard the Mars Reconnaissance Orbiter (MRO) has obtained multiple-filter daily global images of Mars centered upon a local time (LT) of 3 pm. Ultraviolet imaging bands placed within (260 nm) and longward (320 nm) of Hartley band (240-300 nm) ozone (O3) absorption support retrievals of atmospheric ozone columns, with detection limits (approximately 1 micrometer-atm) appropriate to mapping elevated O3 abundances at low latitudes around Mars aphelion, and over mid-to-high latitudes during fall/winter/spring seasons. MARCI O3 maps for these regions reveal the detailed spatial (approximately 1 deg lat/long, for 8 x 8 pixel binned resolution) and temporal (daily, with substantial LT coverage at pole) behaviors of water vapor saturation conditions that force large variations in water vapor photolysis products (HOx-OH, HO2, and H) responsible for the catalytic destruction of O3 in the Mars atmosphere. A detailed description of the MARCI O3 data set, including measurement and retrieval characteristics, is provided in conjunction with comparisons to Mars Express SPICAM ozone measurements (Perrier, S. et al. [2006]. J. Geophys. Res. (Planets) 111) and LMD GCM simulated O3 abundances (Lefevre, F. [2004]. J. Geophys. Res. (Planets) 109). Presented aspects of the MARCI ozone mapping data set include aphelion increases in low latitude O3, dynamically evolving high latitude O3 maxima associated with planetary waves and weather fronts during northern early spring, and distinctive winter/spring O3 and CO increases within the Hellas Basin associated with transport of condensation enhanced south polar air mass. Comparisons of coincident MARCI measurements and LMD simulations for ice cloud and O3 columns are considered in the context of potential heterogeneous photochemical processes (Lefevre, F. [2008]. Nature 454, 971-975), which are not strongly evidenced in the MARCI observations. Modest interannual variations are exhibited

  8. Daily global mapping of Mars ozone column abundances with MARCI UV band imaging

    NASA Astrophysics Data System (ADS)

    Todd Clancy, R.; Wolff, Michael J.; Lefèvre, Franck; Cantor, Bruce A.; Malin, Michael C.; Smith, Michael D.

    2016-03-01

    Since November of 2006, The Mars Color Imager (MARCI) onboard the Mars Reconnaissance Orbiter (MRO) has obtained multiple-filter daily global images of Mars centered upon a local time (LT) of 3 pm. Ultraviolet imaging bands placed within (260 nm) and longward (320 nm) of Hartley band (240-300 nm) ozone (O3) absorption support retrievals of atmospheric ozone columns, with detection limits (∼1 μm-atm) appropriate to mapping elevated O3 abundances at low latitudes around Mars aphelion, and over mid-to-high latitudes during fall/winter/spring seasons. MARCI O3 maps for these regions reveal the detailed spatial (∼1° lat/long, for 8 × 8 pixel binned resolution) and temporal (daily, with substantial LT coverage at pole) behaviors of water vapor saturation conditions that force large variations in water vapor photolysis products (HOx-OH, HO2, and H) responsible for the catalytic destruction of O3 in the Mars atmosphere. A detailed description of the MARCI O3 data set, including measurement and retrieval characteristics, is provided in conjunction with comparisons to Mars Express SPICAM ozone measurements (Perrier, S. et al. [2006]. J. Geophys. Res. (Planets) 111) and LMD GCM simulated O3 abundances (Lefèvre, F. [2004]. J. Geophys. Res. (Planets) 109). Presented aspects of the MARCI ozone mapping data set include aphelion increases in low latitude O3, dynamically evolving high latitude O3 maxima associated with planetary waves and weather fronts during northern early spring, and distinctive winter/spring O3 and CO increases within the Hellas Basin associated with transport of condensation-enhanced south polar air mass. Comparisons of coincident MARCI measurements and LMD simulations for ice cloud and O3 columns are considered in the context of potential heterogeneous photochemical processes (Lefèvre, F. [2008]. Nature 454, 971-975), which are not strongly evidenced in the MARCI observations. Modest interannual variations are exhibited, most notably a 20% reduction

  9. Hypofractionated Prostate Radiotherapy with or without Conventionally Fractionated Nodal Irradiation: Clinical Toxicity Observations and Retrospective Daily Dosimetry.

    PubMed

    McDonald, Andrew M; Bishop, Justin M; Jacob, Rojymon; Dobelbower, Michael C; Kim, Robert Y; Yang, Eddy S; Smith, Heather; Wu, Xingen; Fiveash, John B

    2012-01-01

    Purpose. To evaluate toxicity associated with the addition of elective nodal irradiation (ENI) to a hypofractionated regimen for the treatment of prostate cancer. Methods and Materials. Fifty-seven patients received pelvic image-guided IMRT to 50.4 Gy in 28 fractions with a hypofractionated simultaneous boost to the prostate to 70 Gy. Thirty-one patients received prostate-only treatment to 70 Gy in 28 fractions. Results. Median followup was 41.1 months. Early grade ≥2 urinary toxicity rates were 49% (28 of 57) for patients receiving ENI and 58% (18 of 31) for those not (P = 0.61). Early grade ≥2 rectal toxicity rates were 40% (23 of 57) and 23% (7 of 31), respectively (P = 0.09). The addition of ENI resulted in a 21% actuarial rate of late grade ≥2 rectal toxicity at 4 years, compared to 0% for patients treated to the prostate only (P = 0.02). Retrospective daily dosimetry of patients experiencing late rectal toxicity revealed an average increase of 2.67% of the rectal volume receiving 70 Gy compared to the original plan. Conclusions. The addition of ENI resulted in an increased risk of late rectal toxicity. Grade ≥2 late rectal toxicity was associated with worse daily rectal dosimetry compared to the treatment plan.

  10. Incorporating TRMM and Other High-Quality Estimates into the One-Degree Daily (1DD) Global Precipitation Product

    NASA Technical Reports Server (NTRS)

    Huffman, George J.; Adler, Robert F.; Bolvin, David T.

    1999-01-01

    The One-Degree Daily (1DD) precipitation dataset was recently developed for the Global Precipitation Climatology Project (GPCP). The IDD provides a globally-complete, observation-only estimate of precipitation on a daily 1 deg x 1 deg grid for the period 1997 through late 1999 (by the time of the conference). In the latitude band 40 N - 40 S the IDD uses the Threshold-Matched Precipitation Index (TMPI), a GPI-like IR product with the T(sub b) threshold and (single) conditional rain rate determined locally for each month by the frequency of precipitation in the GPROF SSNU product and by the precipitation amount in the GPCP satellite-gauge (SG) combination. Outside 40 N - 40 S the 1DD uses a scaled TOVS precipitation estimate that has adjustments based on the TMPI and the SG. This first-generation 1DD has been in beta test preparatory to release as an official GPCP product. In this paper we discuss further development of the 1DD framework to allow the direct incorporation of TRMM and other high-quality precipitation estimates. First, these data are generally sparse (typically from low-orbit satellites), so a fair amount of work was devoted to data boundaries. Second, these data are not the same as the original 1DD estimates, so we had to give careful consideration to the best scheme for forcing the 1DD to sum to the SG for the month. Finally, the non-sun-synchronous, low-inclination orbit occupied by TRMM creates interesting variations against the sun-synchronous, high-inclination orbits occupied by the Defense Meteorological Satellite Program satellites that carry the SSM/I. Examples will be given of each of the development issues, then comparisons will be made to daily raingauge analyses.

  11. Twice-daily versus once-daily applications of pimecrolimus cream 1% for the prevention of disease relapse in pediatric patients with atopic dermatitis.

    PubMed

    Ruer-Mulard, Mireille; Aberer, Werner; Gunstone, Anthony; Kekki, Outi-Maria; López Estebaranz, Jose Luis; Vertruyen, André; Guettner, Achim; Hultsch, Thomas

    2009-01-01

    The aim of this study is to compare twice-daily and once-daily applications of pimecrolimus cream 1% for prevention of atopic dermatitis relapses in pediatric patients. This multicenter trial enrolled 300 outpatients aged 2 to 17 years, with mild-to-severe atopic dermatitis. The patients were initially treated with twice-daily topical pimecrolimus until complete clearance or for up to 6 weeks (open-label period). Those who achieved a decrease of at least 1 point in the Investigator's Global Assessment score were then randomized to double-blind treatment with pimecrolimus cream 1% either twice daily or once daily for up to 16 weeks. Study medication was discontinued during periods of disease remission (Investigator's Global Assessment = 0). The primary efficacy end point of the double-blind phase was disease relapse (worsening requiring topical corticosteroids or additional/alternative therapy and confirmed by Investigator's Global Assessment score > or = 3 and pruritus score > or = 2). Of the 300 patients enrolled in the study, 268 were randomized to treatment with pimecrolimus cream 1% either twice daily or once daily (n = 134 in each group). The relapse rate was lower in the twice-daily dose group (9.9%) than that in the once-daily dose group (14.7%), but analysis of the time to disease relapse, using a Cox proportional model to adjust for confounding variables, did not show a statistically significant difference between treatment arms (hazard ratio: 0.64; 95% CI: 0.31-1.30). Treatment of active atopic dermatitis lesions with pimecrolimus cream 1% twice daily, followed by the once-daily dosing regimen, was sufficient to prevent subsequent atopic dermatitis relapses over 16 weeks in pediatric patients.

  12. Accuracy of silicon versus thermopile radiometers for daily and monthly integrated total hemispherical solar radiation

    NASA Astrophysics Data System (ADS)

    Stoffel, Thomas L.; Myers, Daryl R.

    2010-08-01

    Measurement stations for solar radiation resource assessment data are expensive and labor intensive. For this reason, long-term solar radiation measurements are not widely available. Growing interest in solar renewable energy systems has generated a great number of questions about the quality of data obtained from inexpensive silicon photodiode radiometers versus costly thermopile radiometers. We analyze a year of daily total and monthly mean global horizontal irradiance measurements derived from 1-minute averages of 3-second samples of pyranometer signals. The data were collected simultaneously from both types of radiometers at the Solar Radiation Research Laboratory (SRRL) operated by the National Renewable Energy Laboratory in Golden, Colorado. All broadband radiometers in service at SRRL are calibrated annually using an outdoor method with reference radiometers traceable to the World Radiometric Reference. We summarized the data by daily total and monthly mean daily total amounts of solar radiation. Our results show that systematic and random errors (identified in our outdoor calibration process) in each type of radiometer cancel out over periods of one day or more. Daily total and mean monthly daily total solar energy measured by the two pyranometer types compare within 1% to 2%. The individual daily variations among different models of thermopile radiometers may be up to twice as large, up to +/-5%, being highest in the winter (higher average solar zenith angle conditions) and lowest in summer, consistent with the lower solar zenith angle conditions.

  13. A Comparison Between Heliosat-2 and Artificial Neural Network Methods for Global Horizontal Irradiance Retrievals over Desert Environments

    NASA Astrophysics Data System (ADS)

    Ghedira, H.; Eissa, Y.

    2012-12-01

    Global horizontal irradiance (GHI) retrievals at the surface of any given location could be used for preliminary solar resource assessments. More accurately, the direct normal irradiance (DNI) and diffuse horizontal irradiance (DHI) are also required to estimate the global tilt irradiance, mainly used for fixed flat plate collectors. Two different satellite-based models for solar irradiance retrievals have been applied over the desert environment of the United Arab Emirates (UAE). Both models employ channels of the SEVIRI instrument, onboard the geostationary satellite Meteosat Second Generation, as their main inputs. The satellite images used in this study have a temporal resolution of 15-min and a spatial resolution of 3-km. The objective of this study is to compare between the GHI retrieved using the Heliosat-2 method and an artificial neural network (ANN) ensemble method over the UAE. The high-resolution visible channel of SEVIRI is used in the Heliosat-2 method to derive the cloud index. The cloud index is then used to compute the cloud transmission, while the cloud-free GHI is computed from the Linke turbidity factor. The product of the cloud transmission and the cloud-free GHI denotes the estimated GHI. A constant underestimation is observed in the estimated GHI over the dataset available in the UAE. Therefore, the cloud-free DHI equation in the model was recalibrated to fix the bias. After recalibration, results over the UAE show a root mean square error (RMSE) value of 10.1% and a mean bias error (MBE) of -0.5%. As for the ANN approach, six thermal channels of SEVIRI were used to estimate the DHI and the total optical depth of the atmosphere (δ). An ensemble approach is employed to obtain a better generalizability of the results, as opposed to using one single weak network. The DNI is then computed from the estimated δ using the Beer-Bouguer-Lambert law. The GHI is computed from the DNI and DHI estimates. The RMSE for the estimated GHI obtained over an

  14. ONCE DAILY RISPERIDONE IN TREATMENT OF SCHIZOPHRENIA

    PubMed Central

    Agarwal, Vivek; Chadda, Rakesh K.

    2001-01-01

    Forty four schizophrenic patients were randomly assigned to receive risperidone in 4-8 mg doses either once daily or twice daily for 8 weeks. An open trial was conducted to determine the efficacy of once daily administration of risperidone as compared to twice daily administration. Assessment were done on Positive and Negative Syndrome Scale (PANSS) and Clinical Global Impression (CGI) scale Eighty two percent of the once daily patients and 79% of the twice daily patients showed a significant treatment response. No significant differences were observed between the two groups in response pattern and adverse effects at the end point. Risperidone given once daily was as effective as twice daily administration. PMID:21407835

  15. Daily and Hourly Variability in Global Fire Emissions and Consequences for Atmospheric Model Predictions of Carbon Monoxide

    NASA Technical Reports Server (NTRS)

    Mu, M.; Randerson, J. T.; van der Werf, G. R.; Giglio, L.; Kasibhatla, P.; Morton, D.; Collatz, G. J.; DeFries, R. S.; Hyer, E. J.; Prins, E. M.; hide

    2011-01-01

    Attribution of the causes of atmospheric trace gas and aerosol variability often requires the use of high resolution time series of anthropogenic and natural emissions inventories. Here we developed an approach for representing synoptic- and diurnal-scale temporal variability in fire emissions for the Global Fire Emissions Database version 3 (GFED3). We distributed monthly GFED3 emissions during 2003-2009 on a daily time step using Moderate Resolution Imaging Spectroradiometer (MODIS)-derived measurements of active fires from Terra and Aqua satellites. In parallel, mean diurnal cycles were constructed from Geostationary Operational Environmental Satellite (GOES) active fire observations. We found that patterns of daily variability in fires varied considerably across different biomes, with short but intense periods of daily emissions in boreal ecosystems and lower intensity (but more continuous) periods of bunting in savannas. On diurnal timescales, our analysis of the GOES active fires indicated that fires in savannas, grasslands, and croplands occurred earlier in the day as compared to fires in nearby forests. Comparison with Total Carbon Column Observing Network (TCCON) and Measurements of Pollution in the Troposphere (MOPITT) column CO observations provided evidence that including daily variability in emissions moderately improved atmospheric model simulations, particularly during the fire season and near regions with high levels of biomass burning. The high temporal resolution estimates of fire emissions developed here may ultimately reduce uncertainties related to fire contributions to atmospheric trace gases and aerosols. Important future directions include reconciling top-down and bottom up estimates of fire radiative power and integrating burned area and active fire time series from multiple satellite sensors to improve daily emissions estimates.

  16. Design and performance of daily quality assurance system for carbon ion therapy at NIRS

    NASA Astrophysics Data System (ADS)

    Saotome, N.; Furukawa, T.; Hara, Y.; Mizushima, K.; Tansho, R.; Saraya, Y.; Shirai, T.; Noda, K.

    2017-09-01

    At National Institute of Radiological Sciences (NIRS), we have been commissioning a rotating-gantry system for carbon-ion radiotherapy. This rotating gantry can transport heavy ions at 430 MeV/u to an isocenter with irradiation angles of ±180° that can rotate around the patient so that the tumor can be irradiated from any direction. A three-dimensional pencil-beam scanning irradiation system equipped with the rotating gantry enables the optimal use of physical characteristics of carbon ions to provide accurate treatment. To ensure the treatment quality using such a complex system, the calibration of the primary dose monitor, output check, range check, dose rate check, machine safety check, and some mechanical tests should be performed efficiently. For this purpose, we have developed a measurement system dedicated for quality assurance (QA) of this gantry system: the Daily QA system. The system consists of an ionization chamber system and a scintillator system. The ionization chamber system is used for the calibration of the primary dose monitor, output check, and dose rate check, and the scintillator system is used for the range check, isocenter, and gantry angle. The performance of the Daily QA system was verified by a beam test. The stability of the output was within 0.5%, and the range was within 0.5 mm. The coincidence of the coordinates between the patient-positioning system and the irradiation system was verified using the Daily QA system. Our present findings verified that the new Daily QA system for a rotating gantry is capable of verifying the irradiation system with sufficient accuracy.

  17. Reconstruction of solar spectral surface UV irradiances using radiative transfer simulations.

    PubMed

    Lindfors, Anders; Heikkilä, Anu; Kaurola, Jussi; Koskela, Tapani; Lakkala, Kaisa

    2009-01-01

    UV radiation exerts several effects concerning life on Earth, and spectral information on the prevailing UV radiation conditions is needed in order to study each of these effects. In this paper, we present a method for reconstruction of solar spectral UV irradiances at the Earth's surface. The method, which is a further development of an earlier published method for reconstruction of erythemally weighted UV, relies on radiative transfer simulations, and takes as input (1) the effective cloud optical depth as inferred from pyranometer measurements of global radiation (300-3000 nm); (2) the total ozone column; (3) the surface albedo as estimated from measurements of snow depth; (4) the total water vapor column; and (5) the altitude of the location. Reconstructed daily cumulative spectral irradiances at Jokioinen and Sodankylä in Finland are, in general, in good agreement with measurements. The mean percentage difference, for instance, is mostly within +/-8%, and the root mean square of the percentage difference is around 10% or below for wavelengths over 310 nm and daily minimum solar zenith angles (SZA) less than 70 degrees . In this study, we used pseudospherical radiative transfer simulations, which were shown to improve the performance of our method under large SZA (low Sun).

  18. Estimation of atmospheric turbidity and surface radiative parameters using broadband clear sky solar irradiance models in Rio de Janeiro-Brasil

    NASA Astrophysics Data System (ADS)

    Flores, José L.; Karam, Hugo A.; Marques Filho, Edson P.; Pereira Filho, Augusto J.

    2016-02-01

    The main goal of this paper is to estimate a set of optimal seasonal, daily, and hourly values of atmospheric turbidity and surface radiative parameters Ångström's turbidity coefficient ( β), Ångström's wavelength exponent ( α), aerosol single scattering albedo ( ω o ), forward scatterance ( F c ) and average surface albedo ( ρ g ), using the Brute Force multidimensional minimization method to minimize the difference between measured and simulated solar irradiance components, expressed as cost functions. In order to simulate the components of short-wave solar irradiance (direct, diffuse and global) for clear sky conditions, incidents on a horizontal surface in the Metropolitan Area of Rio de Janeiro (MARJ), Brazil (22° 51' 27″ S, 43° 13' 58″ W), we use two parameterized broadband solar irradiance models, called CPCR2 and Iqbal C, based on synoptic information. The meteorological variables such as precipitable water ( u w ) and ozone concentration ( u o ) required by the broadband solar models were obtained from moderate-resolution imaging spectroradiometer (MODIS) sensor on Terra and Aqua NASA platforms. For the implementation and validation processes, we use global and diffuse solar irradiance data measured by the radiometric platform of LabMiM, located in the north area of the MARJ. The data were measured between the years 2010 and 2012 at 1-min intervals. The performance of solar irradiance models using optimal parameters was evaluated with several quantitative statistical indicators and a subset of measured solar irradiance data. Some daily results for Ångström's wavelength exponent α were compared with Ångström's parameter (440-870 nm) values obtained by aerosol robotic network (AERONET) for 11 days, showing an acceptable level of agreement. Results for Ångström's turbidity coefficient β, associated with the amount of aerosols in the atmosphere, show a seasonal pattern according with increased precipitation during summer months (December

  19. A Temperature-Based Model for Estimating Monthly Average Daily Global Solar Radiation in China

    PubMed Central

    Li, Huashan; Cao, Fei; Wang, Xianlong; Ma, Weibin

    2014-01-01

    Since air temperature records are readily available around the world, the models based on air temperature for estimating solar radiation have been widely accepted. In this paper, a new model based on Hargreaves and Samani (HS) method for estimating monthly average daily global solar radiation is proposed. With statistical error tests, the performance of the new model is validated by comparing with the HS model and its two modifications (Samani model and Chen model) against the measured data at 65 meteorological stations in China. Results show that the new model is more accurate and robust than the HS, Samani, and Chen models in all climatic regions, especially in the humid regions. Hence, the new model can be recommended for estimating solar radiation in areas where only air temperature data are available in China. PMID:24605046

  20. Azelaic acid 15% gel once daily versus twice daily in papulopustular rosacea.

    PubMed

    Thiboutot, Diane M; Fleischer, Alan B; Del Rosso, James Q; Graupe, Klaus

    2008-06-01

    Twice-daily azelaic acid (AzA) is the conventional regimen for papulopustular rosacea, but once-daily AzA may be equally effective, with greater convenience and dosing flexibility. In order to test this hypothesis, an exploratory study was conducted. The evaluable efficacy population of this 12-week double-blind, parallel-group study included 72 patients and the population that was used to report safety results included 92 patients. Baseline characteristics were comparable between the once-daily and twice-daily study groups. Evaluations were performed at baseline and at weeks 4, 8, and 12. No significant difference was found between the once-daily and twice-daily groups at the end of study therapy in mean investigator global assessment (IGA) scores, treatment success, or treatment response. The mean number of inflammatory lesions, the intensity of erythema intensity, and the intensity of telangiectasia at treatment end were likewise not significantly different (P>.205 for all). More than 90% of subjects in each group rated cosmetic acceptability of this AzA gel as satisfactory or better. Based on these findings and those of prior studies, once-daily AzA 15% gel can therefore be utilized as a safe, effective, and economical dosing option for the treatment of mild-to-moderate papulopustular rosacea. Once-daily dosing of AzA 15% gel was well accepted by patients and can offer considerable dosing flexibility and convenience for the patient as well as for the dermatologist.

  1. TU-H-CAMPUS-TeP2-02: FLASH Irradiation Improves the Therapeutic Index Following GI Tract Irradiation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Schueler, E; Trovati, S; King, G

    Purpose: To investigate and characterize the radiobiological effectiveness of very high dose rate radiotherapy (FLASH) compared to conventional irradiation in an in vivo model. Methods: The gastrointestinal (GI) tract of C57BL/6 mice were irradiated with doses ranging between 10 and 18 Gy using a custom stereotactic jig. A Varian Clinac 21EX was modified to allow dose rates ranging from 0.05 to 240 Gy/s at the position of the mirror. With the gantry at 180 degrees, the jig holding the individual animals was placed above the mirror to take advantage of the reduced source to target distance. Mice were irradiated withmore » 20MeV electrons. Following irradiation, the mice were monitored twice daily for morbidity and daily for weight changes. Results: Mice irradiated with FLASH irradiation had lower weight loss compared to the mice receiving conventional irradiation. Following FLASH irradiation, a maximum weight loss of ∼20% was observed at day 6 with subsequent recovery, while following conventional irradiation, higher weight losses was observed with fewer instances of recovery. Concerning survival, all mice in the conventionally irradiated groups had a 100% mortality in the range of 15.5–18 Gy, while the mice irradiated with FLASH irradiation had a 100% survival in the same range. Conclusion: These results have demonstrated proof of principle that FLASH irradiations have a dramatic impact on the overall survival of mice following GI tract irradiations. If the increase in the therapeutic window can be validated and understood, this would revolutionize the field of radiation oncology and lead to increased cure rates with reduced side effects following treatment, resulting in increased quality of life for cancer survivors. Funding: DoD, Award#:W81XWH-14-1-0014, Weston Havens Foundation, Bio-X (Stanford University), the Office of the Dean of the Medical School, the Office of the Provost (Stanford University), and the Swedish Childhood Cancer Foundation; BL and PM

  2. Recent Trends in Global Ocean Chlorophyll

    NASA Technical Reports Server (NTRS)

    Gregg, Watson; Casey, Nancy

    2004-01-01

    Recent analyses of SeaWiFS data have shown that global ocean chlorophyll has increased more than 5% since 1998. The North Pacific ocean basin has increased nearly 19%. To understand the causes of these trends we have applied the newly developed NASA Ocean Biogeochemical Assimilation Model (OBAM), which is driven in mechanistic fashion by surface winds, sea surface temperature, atmospheric iron deposition, sea ice, and surface irradiance. The mode1 utilizes chlorophyll from SeaWiFS in a daily assimilation. The model has in place many of the climatic variables that can be expected to produce the changes observed in SeaWiFS data. Ths enables us to diagnose the model performance, the assimilation performance, and possible causes for the increase in chlorophyll.

  3. Probabilistic global maps of the CO2 column at daily and monthly scales from sparse satellite measurements

    NASA Astrophysics Data System (ADS)

    Chevallier, Frédéric; Broquet, Grégoire; Pierangelo, Clémence; Crisp, David

    2017-07-01

    The column-average dry air-mole fraction of carbon dioxide in the atmosphere (XCO2) is measured by scattered satellite measurements like those from the Orbiting Carbon Observatory (OCO-2). We show that global continuous maps of XCO2 (corresponding to level 3 of the satellite data) at daily or coarser temporal resolution can be inferred from these data with a Kalman filter built on a model of persistence. Our application of this approach on 2 years of OCO-2 retrievals indicates that the filter provides better information than a climatology of XCO2 at both daily and monthly scales. Provided that the assigned observation uncertainty statistics are tuned in each grid cell of the XCO2 maps from an objective method (based on consistency diagnostics), the errors predicted by the filter at daily and monthly scales represent the true error statistics reasonably well, except for a bias in the high latitudes of the winter hemisphere and a lack of resolution (i.e., a too small discrimination skill) of the predicted error standard deviations. Due to the sparse satellite sampling, the broad-scale patterns of XCO2 described by the filter seem to lag behind the real signals by a few weeks. Finally, the filter offers interesting insights into the quality of the retrievals, both in terms of random and systematic errors.

  4. Global, Daily, Near Real-Time Satellite-based Flood Monitoring and Product Dissemination

    NASA Astrophysics Data System (ADS)

    Slayback, D. A.; Policelli, F. S.; Brakenridge, G. R.; Tokay, M. M.; Smith, M. M.; Kettner, A. J.

    2013-12-01

    Flooding is the most destructive, frequent, and costly natural disaster faced by modern society, and is expected to increase in frequency and damage with climate change and population growth. Some of 2013's major floods have impacted the New York City region, the Midwest, Alberta, Australia, various parts of China, Thailand, Pakistan, and central Europe. The toll of these events, in financial costs, displacement of individuals, and deaths, is substantial and continues to rise as climate change generates more extreme weather events. When these events do occur, the disaster management community requires frequently updated and easily accessible information to better understand the extent of flooding and better coordinate response efforts. With funding from NASA's Applied Sciences program, we developed and are now operating a near real-time global flood mapping system to help provide critical flood extent information within 24-48 hours of events. The system applies a water detection algorithm to MODIS imagery received from the LANCE (Land Atmosphere Near real-time Capability for EOS) system at NASA Goddard within a few hours of satellite overpass. Using imagery from both the Terra (10:30 AM local time overpass) and Aqua (1:30 PM) platforms allows an initial daily assessment of flooding extent by late afternoon, and more robust assessments after accumulating cloud-free imagery over several days. Cloud cover is the primary limitation in detecting surface water from MODIS imagery. Other issues include the relatively coarse scale of the MODIS imagery (250 meters), the difficulty of detecting flood waters in areas with continuous canopy cover, confusion of shadow (cloud or terrain) with water, and accurately identifying detected water as flood as opposed to normal water extents. We have made progress on many of these issues, and are working to develop higher resolution flood detection using alternate sensors, including Landsat and various radar sensors. Although these

  5. Global surface density of water mass variations by using a two-step inversion by cumulating daily satellite gravity information

    NASA Astrophysics Data System (ADS)

    Ramillien, Guillaume; Frappart, Frédéric; Seoane, Lucia

    2016-04-01

    We propose a new method to produce time series of global maps of surface mass variations by progressive integration of daily geopotential variations measured by orbiting satellites. In the case of the GRACE mission, these geopotential variations can be determined from very accurate inter-satellite K-Band Range Rate (KBRR) measurements of 5-second daily orbits. In particular, the along-track gravity contribution of hydrological mass changes is extracted by removing de-aliasing models for static field, atmosphere, oceans mass variations (including periodical tides), as well as polar movements. Our determination of surface mass sources is composed of two successive dependent Kalman filter stages. The first one consists of reducing the satellite-based potential anomalies by adjusting the longest spatial wavelengths (i.e., low-degree spherical harmonics lower than 2). In the second stage, the residual potential anomalies from the previous stage are used to recover surface mass density changes - in terms of Equivalent-Water Height (EWH) - over a global network of juxtaposed triangular elements. These surface tiles of ~100,000 km x km (or equivalently 330 km by 330 km) are defined to be of equal areas over the terrestrial sphere. However they can be adapted to the local geometry of the surface mass. Our global approach was tested by inverting geopotential data, and successfully applied to estimate time-varying surface mass densities from real GRACE-based residuals. This strategy of combined Kalman filter-type inversions can also be useful for exploring the possibility of improving time and space resolutions for ocean and land studies that would be hopefully brought by future low altitude geodetic missions.

  6. Intergenerational Support in a Daily Context

    PubMed Central

    Fingerman, Karen L.; Kim, Kyungmin; Tennant, Patrick S.; Birditt, Kira S.; Zarit, Steven H.

    2016-01-01

    Purpose of the Study: Using retrospective global reports, studies have found that middle-aged adults in the United States provide intermittent support to their aging parents and more frequent support to grown children. To date, studies have not examined support middle-aged adults provide to different generations on a daily basis. Daily support may include mundane everyday exchanges that may (or may not) affect well-being. Design and Methods: Middle-aged adults (N = 191, mean age 55.93) completed a general interview regarding family ties, followed by interviews each day for 7 days (N = 1,261 days). Daily interviews assessed support (e.g., advice, emotional, practical help) participants provided each grown child (n = 454) and aging parent (n = 253). Participants also reported daily mood. Results: Most participants provided emotional support (80%), advice (87%), and practical help (69%) to a grown child and also provided emotional support (61%) and advice (61%) or practical help (43%) to a parent that week. Multilevel models confirmed generational differences; grown children were more likely to receive everyday support than parents. Providing support to grown children was associated with positive mood, whereas providing support to parents was associated with more negative mood. Implications: Daily intergenerational support was more common than studies using global reports of support have found. Some daily support may be fleeting and not stand out in memory. The findings were consistent with the intergenerational stake hypothesis, which suggests middle-aged adults are more invested in their grown children than in their parents. Nonetheless, middle-aged adults were highly involved with aging parents. PMID:26035892

  7. The impact of laser irradiation on global stability in patients with vertebrobasilar insufficiency: A clinical report

    PubMed Central

    Lukowicz, Malgorzata; Zalewski, Pawel; Bulatowicz, Irena; Buszko, Katarzyna; Klawe, Jacek J.

    2011-01-01

    Summary Background The purpose of our experiment was to determine whether laser stimulation can improve microcirculation in the posterior regions of the brain in patients with vertebrobasilar insufficiency (VBI). Material/Methods We studied 25 patients (20 female, 5 male, mean age 64) diagnosed with chronic VBI. All were evaluated using the De Klyn test, followed by qualitative assessment of stability using a Berg Balance Scale and evaluation of global stability using an electronic balance platform. A CTL-1100 low power laser was used with standard parameters. We established a protocol for laser irradiation at 5 points along the vertebral artery in the cervical region bilaterally. Irradiation was performed 10 times over two weeks. Results Significant improvement occurred after therapy in headache (p=0.0005), vertigo (p<0.0000), and tinnitus (p=0.0387). No significant differences were observed in nausea or nystagmus caused by head rotation. The Berg Balance Scale results showed significant differences in almost all features. There was a tendency towards improved stability in all parameters, and statistically significant differences in the total surface of support and the spread surface of support for the left foot. Conclusions Laser stimulation as applied in this study can be useful in the treatment of patients with VBI. The main reason for improvement in global stability, balance, and other VBI symptoms is better blood perfusion. PMID:21873949

  8. Active Cavity Irradiance Monitor Satellite ACRIMSAT Artist Concept

    NASA Image and Video Library

    1999-12-21

    The Active Cavity Irradiance Monitor Satellite, or ACRIMSAT, mission is a climate change investigation that measures changes in how much of the sun's energy reaches Earth's atmosphere. This energy, called solar irradience, creates winds, heats the land and drives ocean currents, and therefore contains significant data that climatologists can use to improve predictions of climate change and global warming. The satellite's Active Cavity Irradiance Monitor III instrument, now in its third generation, has been used since the 1980s to study solar irradiance and its impacts on global warming. Scientists, using data from the instrument, now theorize that there is a significant correlation between solar radiation and global warming. ACRIMSAT completed its five-year primary mission in 2005 when it began operating under its extended mission. http://photojournal.jpl.nasa.gov/catalog/PIA18157

  9. Daily and 3-hourly Variability in Global Fire Emissions and Consequences for Atmospheric Model Predictions of Carbon Monoxide

    NASA Technical Reports Server (NTRS)

    Mu, M.; Randerson, J. T.; vanderWerf, G. R.; Giglio, L.; Kasibhatla, P.; Morton, D.; Collatz, G. J.; DeFries, R. S.; Hyer, E. J.; Prins, E. M.; hide

    2011-01-01

    Attribution of the causes of atmospheric trace gas and aerosol variability often requires the use of high resolution time series of anthropogenic and natural emissions inventories. Here we developed an approach for representing synoptic- and diurnal-scale temporal variability in fire emissions for the Global Fire Emissions Database version 3 (GFED3). We disaggregated monthly GFED3 emissions during 2003.2009 to a daily time step using Moderate Resolution Imaging Spectroradiometer (MODIS) ]derived measurements of active fires from Terra and Aqua satellites. In parallel, mean diurnal cycles were constructed from Geostationary Operational Environmental Satellite (GOES) Wildfire Automated Biomass Burning Algorithm (WF_ABBA) active fire observations. Daily variability in fires varied considerably across different biomes, with short but intense periods of daily emissions in boreal ecosystems and lower intensity (but more continuous) periods of burning in savannas. These patterns were consistent with earlier field and modeling work characterizing fire behavior dynamics in different ecosystems. On diurnal timescales, our analysis of the GOES WF_ABBA active fires indicated that fires in savannas, grasslands, and croplands occurred earlier in the day as compared to fires in nearby forests. Comparison with Total Carbon Column Observing Network (TCCON) and Measurements of Pollution in the Troposphere (MOPITT) column CO observations provided evidence that including daily variability in emissions moderately improved atmospheric model simulations, particularly during the fire season and near regions with high levels of biomass burning. The high temporal resolution estimates of fire emissions developed here may ultimately reduce uncertainties related to fire contributions to atmospheric trace gases and aerosols. Important future directions include reconciling top ]down and bottom up estimates of fire radiative power and integrating burned area and active fire time series from

  10. Downward solar global irradiance at the surface in São Paulo city—The climatological effects of aerosol and clouds

    NASA Astrophysics Data System (ADS)

    Yamasoe, M. A.; do Rosário, N. M. E.; Barros, K. M.

    2017-01-01

    We analyzed the variability of downward solar irradiance reaching the surface at São Paulo city, Brazil, and estimated the climatological aerosol and cloud radiative effects. Eleven years of irradiance were analyzed, from 2005 to 2015. To distinguish the aerosol from the cloud effect, the radiative transfer code LibRadtran was used to calculate downward solar irradiance. Two runs were performed, one considering only ozone and water vapor daily variability, with AOD set to zero and the second allowing the three variables to change, according to mean climatological values. The difference of the 24 h mean irradiance calculated with and without aerosol resulted in the shortwave aerosol direct radiative effect, while the difference between the measured and calculated, including the aerosol, represented the cloud effect. Results showed that, climatologically, clouds can be 4 times more effective than aerosols. The cloud shortwave radiative effect presented a maximum reduction of about -170 W m-2 in January and a minimum in July, of -37 W m-2. The aerosol direct radiative effect was maximum in spring, when the transport of smoke from the Amazon and central parts of South America is frequent toward São Paulo. Around mid-September, the 24 h radiative effect due to aerosol only was estimated to be -50 W m-2. Throughout the rest of the year, the mean aerosol effect was around -20 W m-2 and was attributed to local urban sources. The effect of the cloud fraction on the cloud modification factor, defined as the ratio of all-sky irradiation to cloudless sky irradiation, showed dependence on the cloud height. Low clouds presented the highest impact while the presence of high clouds only almost did not affect solar transmittance, even in overcast conditions.

  11. Uncertainty Assessment of the NASA Earth Exchange Global Daily Downscaled Climate Projections (NEX-GDDP) Dataset

    NASA Technical Reports Server (NTRS)

    Wang, Weile; Nemani, Ramakrishna R.; Michaelis, Andrew; Hashimoto, Hirofumi; Dungan, Jennifer L.; Thrasher, Bridget L.; Dixon, Keith W.

    2016-01-01

    The NASA Earth Exchange Global Daily Downscaled Projections (NEX-GDDP) dataset is comprised of downscaled climate projections that are derived from 21 General Circulation Model (GCM) runs conducted under the Coupled Model Intercomparison Project Phase 5 (CMIP5) and across two of the four greenhouse gas emissions scenarios (RCP4.5 and RCP8.5). Each of the climate projections includes daily maximum temperature, minimum temperature, and precipitation for the periods from 1950 through 2100 and the spatial resolution is 0.25 degrees (approximately 25 km x 25 km). The GDDP dataset has received warm welcome from the science community in conducting studies of climate change impacts at local to regional scales, but a comprehensive evaluation of its uncertainties is still missing. In this study, we apply the Perfect Model Experiment framework (Dixon et al. 2016) to quantify the key sources of uncertainties from the observational baseline dataset, the downscaling algorithm, and some intrinsic assumptions (e.g., the stationary assumption) inherent to the statistical downscaling techniques. We developed a set of metrics to evaluate downscaling errors resulted from bias-correction ("quantile-mapping"), spatial disaggregation, as well as the temporal-spatial non-stationarity of climate variability. Our results highlight the spatial disaggregation (or interpolation) errors, which dominate the overall uncertainties of the GDDP dataset, especially over heterogeneous and complex terrains (e.g., mountains and coastal area). In comparison, the temporal errors in the GDDP dataset tend to be more constrained. Our results also indicate that the downscaled daily precipitation also has relatively larger uncertainties than the temperature fields, reflecting the rather stochastic nature of precipitation in space. Therefore, our results provide insights in improving statistical downscaling algorithms and products in the future.

  12. The NASA POWER SSE: Deriving the Direct Normal Counterpart from the CERES SYN1deg Hourly Global Horizontal Irradiance during Early 2000 to Near Present

    NASA Astrophysics Data System (ADS)

    Zhang, T.; Stackhouse, P. W., Jr.; Westberg, D. J.

    2017-12-01

    The NASA Prediction of Worldwide Energy Resource (POWER) Surface meteorology and Solar Energy (SSE) provides solar direct normal irradiance (DNI) data as well as a variety of other solar parameters. The currently available DNIs are monthly means on a quasi-equal-area grid system with grid boxes roughly equivalent to 1 degree longitude by 1 degree latitude around the equator from July 1983 to June 2005, and the data were derived from the GEWEX Surface Radiation Budget (SRB) monthly mean global horizontal irradiance (GHI, Release 3) and regression analysis of the Baseline Surface Radiation Network (BSRN) data. To improve the quality of the DNI data and push the temporal coverage of the data to near present, we have applied a modified version of the DIRINDEX global-to-beam model to the GEWEX SRB (Release 3) all-sky and clear-sky 3-hourly GHI data and derived their DNI counterparts for the period from July 1983 to December 2007. The results have been validated against the BSRN data. To further expand the data in time to near present, we are now applying the DIRINDEX model to the Clouds and the Earth's Radiant Energy System (CERES) data. The CERES SYN1deg (Edition 4A) offers hourly all-sky and clear-sky GHIs on a 1 degree longitude by 1 degree latitude grid system from March 2000 to October 2016 as of this writing. Comparisons of the GHIs with their BSRN counterparts show remarkable agreements. Besides the GHIs, the inputs will also include the atmospheric water vapor and surface pressure from the Modern Era Retrospective-Analysis for Research and Applications (MERRA) and the aerosol optical depth from the Max-Planck Institute Climatology (MAC-v1). Based on the performance of the DIRINDEX model with the GEWEX SRB GHI data, we expect at least equally good or even better results. In this paper, we will show the derived hourly, daily, and monthly mean DNIs from the CERES SYN1deg hourly GHIs from March 2000 to October 2016 and how they compare with the BSRN data.

  13. Intergenerational Support in a Daily Context.

    PubMed

    Fingerman, Karen L; Kim, Kyungmin; Tennant, Patrick S; Birditt, Kira S; Zarit, Steven H

    2016-10-01

    Using retrospective global reports, studies have found that middle-aged adults in the United States provide intermittent support to their aging parents and more frequent support to grown children. To date, studies have not examined support middle-aged adults provide to different generations on a daily basis. Daily support may include mundane everyday exchanges that may (or may not) affect well-being. Middle-aged adults (N = 191, mean age 55.93) completed a general interview regarding family ties, followed by interviews each day for 7 days (N = 1,261 days). Daily interviews assessed support (e.g., advice, emotional, practical help) participants provided each grown child (n = 454) and aging parent (n = 253). Participants also reported daily mood. Most participants provided emotional support (80%), advice (87%), and practical help (69%) to a grown child and also provided emotional support (61%) and advice (61%) or practical help (43%) to a parent that week. Multilevel models confirmed generational differences; grown children were more likely to receive everyday support than parents. Providing support to grown children was associated with positive mood, whereas providing support to parents was associated with more negative mood. Daily intergenerational support was more common than studies using global reports of support have found. Some daily support may be fleeting and not stand out in memory. The findings were consistent with the intergenerational stake hypothesis, which suggests middle-aged adults are more invested in their grown children than in their parents. Nonetheless, middle-aged adults were highly involved with aging parents. © The Author 2015. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  14. Hyperspectral radiometer for automated measurement of global and diffuse sky irradiance

    NASA Astrophysics Data System (ADS)

    Kuusk, Joel; Kuusk, Andres

    2018-01-01

    An automated hyperspectral radiometer for the measurement of global and diffuse sky irradiance, SkySpec, has been designed for providing the SMEAR-Estonia research station with spectrally-resolved solar radiation data. The spectroradiometer has been carefully studied in the optical radiometry laboratory of Tartu Observatory, Estonia. Recorded signals are corrected for spectral stray light as well as for changes in dark signal and spectroradiometer spectral responsivity due to temperature effects. Comparisons with measurements of shortwave radiation fluxes made at the Baseline Surface Radiation Network (BSRN) station at Tõravere, Estonia, and with fluxes simulated using the atmospheric radiative transfer model 6S and Aerosol Robotic Network (AERONET) data showed that the spectroradiometer is a reliable instrument that provides accurate estimates of integrated fluxes and of their spectral distribution. The recorded spectra can be used to estimate the amount of atmospheric constituents such as aerosol and column water vapor, which are needed for the atmospheric correction of spectral satellite images.

  15. An extended global Earth system data record on daily landscape freeze-thaw status determined from satellite passive microwave remote sensing

    NASA Astrophysics Data System (ADS)

    Kim, Youngwook; Kimball, John S.; Glassy, Joseph; Du, Jinyang

    2017-02-01

    The landscape freeze-thaw (FT) signal determined from satellite microwave brightness temperature (Tb) observations has been widely used to define frozen temperature controls on land surface water mobility and ecological processes. Calibrated 37 GHz Tb retrievals from the Scanning Multichannel Microwave Radiometer (SMMR), Special Sensor Microwave Imager (SSM/I), and SSM/I Sounder (SSMIS) were used to produce a consistent and continuous global daily data record of landscape FT status at 25 km grid cell resolution. The resulting FT Earth system data record (FT-ESDR) is derived from a refined classification algorithm and extends over a larger domain and longer period (1979-2014) than prior FT-ESDR releases. The global domain encompasses all land areas affected by seasonal frozen temperatures, including urban, snow- and ice-dominant and barren land, which were not represented by prior FT-ESDR versions. The FT retrieval is obtained using a modified seasonal threshold algorithm (MSTA) that classifies daily Tb variations in relation to grid-cell-wise FT thresholds calibrated using surface air temperature data from model reanalysis. The resulting FT record shows respective mean annual spatial classification accuracies of 90.3 and 84.3 % for evening (PM) and morning (AM) overpass retrievals relative to global weather station measurements. Detailed data quality metrics are derived characterizing the effects of sub-grid-scale open water and terrain heterogeneity, as well as algorithm uncertainties on FT classification accuracy. The FT-ESDR results are also verified against other independent cryospheric data, including in situ lake and river ice phenology, and satellite observations of Greenland surface melt. The expanded FT-ESDR enables new investigations encompassing snow- and ice-dominant land areas, while the longer record and favorable accuracy allow for refined global change assessments that can better distinguish transient weather extremes, landscape phenological shifts

  16. Age differences in emotional responses to daily stress: The role of timing, severity, and global perceived stress

    PubMed Central

    Scott, Stacey B.; Sliwinski, Martin J.; Blanchard Fields, Fredda

    2013-01-01

    Research on age differences in emotional responses to daily stress has produced inconsistent findings. Guided by recent theoretical advances in aging theory (Charles, 2010) that emphasize the importance of context for predicting when and how age is related to affective well-being, the current study examined age differences in emotional responses to everyday stressors. The present study examines how three contextual features (e.g., timing of exposure, stressor severity, global perceived stress [GPS]) moderate age differences in emotional experience in an ecological momentary assessment study of adults aged 18–81 (N=190). Results indicated older adults’ negative affect (NA) was less affected by exposure to recent stressors than younger adults, but that there were no age differences in the effects of stressor exposure three to six hours afterward. Higher levels of GPS predicted amplified NA responses to daily stress, and controlling for GPS eliminated age differences in NA responses to stressors. No age differences in NA responses as a function of stressor severity were observed. In contrast, older age was associated with less of a decrease in PA when exposed to recent stressors or with more severe recent stressors. There were no age differences in the effect of previous stressor exposure or severity on PA, nor any interactions between momentary or previous stress and GPS on PA. Together, these results support the notion that chronic stress plays a central role in emotional experience in daily life. Implications of these results for emotion theories of aging are discussed. PMID:24364410

  17. Global Horizontal Irradiance Anomalies in Long Term Series Over India

    NASA Astrophysics Data System (ADS)

    Cony, Marco; Liria, Juan; Weisenberg, Ralf; Serrano, Enrique

    2014-05-01

    India has a high potential for solar energy applications due to its geographic position within the Sun Belt and the large number of cloudless days in many regions of the country. However, certain regions of India, particularly those largely populated, can exhibit large aerosol loading in the atmosphere as a consequence of anthropogenic emissions that could have a negative feedback in the solar resource potential. This effect, named as solar dimming, has already been observed in India, and in some other regions in the world, by some authors using ground data from the last two decades. The recent interest in the promotion of solar energy applications in India highlights the need of extending and improving the knowledge of the solar radiation resources in this country, since most of the long term measurements available correspond to global horizontal radiation (GHI) and most of them are also located big cities or highly populated areas. In addition, accurate knowledge on the aerosol column quantification and on its dynamical behavior with high spatial resolution is particularly important in the case of India, due to their impact on direct normal irradiation. Long term studies of solar irradiation over India can be performed using monthly means of GHI measurements from the Indian Meteorological Department. Ground data are available from 1964 till today through the World Radiation Data Centre that publish these values in the web. This work shows a long term analysis of GHI using anomalies techniques over ten different sites over India. Besides, techniques of linear trends have been applied for to show the evolution over this period. The analysis of anomalies has also found two periods of different behavior. From 1964 till 1988 the anomalies observed were positive and the last 20 years seems to be a period of negative anomalies. The results exhibit a decreasing trend and negative anomalies confirming thus the darkening effect already reported by solar dimming studies

  18. Comparison of once-daily versus twice-daily combination of ropinirole prolonged release in Parkinson's disease.

    PubMed

    Yun, Ji Young; Kim, Han-Joon; Lee, Jee-Young; Kim, Young Eun; Kim, Ji Seon; Kim, Jong-Min; Jeon, Beom S

    2013-09-02

    Ropinirole prolonged release (RPR) is a once-daily formulation. However, there may be individual pharmacokinetic differences so that multiple dosing may be preferred in some individuals. This study compares once-daily and twice-daily RPR in patients with Parkinson's disease. This study was an open-label crossover study. We enrolled Parkinson's disease patients on dopamine agonist therapy with unsatisfactory control such as motor fluctuation, dyskinesia and sleep-related problems. Agonists were switched into equivalent dose of RPR. Subjects were consecutively enrolled into either once-daily first or twice-daily first groups, and received the same amount of RPR in a single and two divided dosing for 8 weeks respectively in a crossover manner without a washout period.The primary outcome was a questionnaire of the preference completed by patients in the last visit. The secondary outcome measures included the Unified Parkinson's Disease Rating Scale part 3 (mUPDRS), Hoehn and Yahr stage (H&Y); sleep questionnaire including overall quality of sleep, nocturnal off symptoms and early morning symptoms; Epworth Sleep Scale (ESS); compliances and patient global impression (PGI). A total of 82 patients were enrolled and 61 completed the study. 31 patients preferred twice-daily regimen, 17 preferred the once-daily regimen, and 13 had no preference. Their mean mUPDRS, H&Y, ESS, sleep quality, compliance and adverse events were not statistically different in both regimens. PGI-improvement on wearing off defined was better in twice-daily dosing regimen. RPR is a once-daily formulation, but multiple dosing was preferred in many patients. Multiple dosing of RPR might be a therapeutic option if once-daily dosing is unsatisfactory.

  19. Time-course study of different innate immune mediators produced by UV-irradiated skin: comparative effects of short and daily versus a single harmful UV exposure.

    PubMed

    Cela, Eliana M; Friedrich, Adrian; Paz, Mariela L; Vanzulli, Silvia I; Leoni, Juliana; González Maglio, Daniel H

    2015-05-01

    The modulatory effects of solar UV radiation on the immune system have been widely studied. As the skin is the main target of UV radiation, our purpose was to compare the impact on skin innate immunity of two contrasting ways to be exposed to sunlight. Hairless mice were UV irradiated with a single high UV dose simulating a harmful exposure, or with repetitive low UV doses simulating short occasional daily exposures. Skin samples were taken at different times after UV irradiation to evaluate skin histology, inflammatory cell recruitment, epidermal T-cell population and the mitochondrial function of epidermal cells. The transcriptional profiles of pro-inflammatory cytokines, chemokines, antimicrobial peptides and Toll-like receptors were evaluated by RT-PCR and ELISA in tissue homogenates. Finally, a lymphangiography was performed to assess modification in the lymphatic vessel system. A single high UV dose produces a deep inflammatory state characterized by the production of pro-inflammatory cytokines and chemokines that, in turn, induces the recruitment of neutrophils and macrophages into the irradiated area. On the other hand, repetitive low UV doses drive the skin to a photo-induced alert state in which there is no sign of inflammation, but the epithelium undergoes changes in thickness, the lymphatic circulation increases, and the transcription of antimicrobial peptides is induced. © 2014 John Wiley & Sons Ltd.

  20. Local warming: daily temperature change influences belief in global warming.

    PubMed

    Li, Ye; Johnson, Eric J; Zaval, Lisa

    2011-04-01

    Although people are quite aware of global warming, their beliefs about it may be malleable; specifically, their beliefs may be constructed in response to questions about global warming. Beliefs may reflect irrelevant but salient information, such as the current day's temperature. This replacement of a more complex, less easily accessed judgment with a simple, more accessible one is known as attribute substitution. In three studies, we asked residents of the United States and Australia to report their opinions about global warming and whether the temperature on the day of the study was warmer or cooler than usual. Respondents who thought that day was warmer than usual believed more in and had greater concern about global warming than did respondents who thought that day was colder than usual. They also donated more money to a global-warming charity if they thought that day seemed warmer than usual. We used instrumental variable regression to rule out some alternative explanations.

  1. Three-year outcomes of a once daily fractionation scheme for accelerated partial breast irradiation (APBI) using 3-D conformal radiotherapy (3D-CRT)

    PubMed Central

    Goyal, Sharad; Daroui, Parima; Khan, Atif J; Kearney, Thomas; Kirstein, Laurie; Haffty, Bruce G

    2013-01-01

    The aim of this study was to report 3-year outcomes of toxicity, cosmesis, and local control using a once daily fractionation scheme (49.95 Gy in 3.33 Gy once daily fractions) for accelerated partial breast irradiation (APBI) using three-dimensional conformal radiotherapy (3D-CRT). Between July 2008 and August 2010, women aged ≥40 years with ductal carcinoma in situ or node-negative invasive breast cancer ≤3 cm in diameter, treated with breast-conserving surgery achieving negative margins, were accrued to a prospective study. Women were treated with APBI using 3–5 photon beams, delivering 49.95 Gy over 15 once daily fractions over 3 weeks. Patients were assessed for toxicities, cosmesis, and local control rates before APBI and at specified time points. Thirty-four patients (mean age 60 years) with Tis 0 (n = 9) and T1N0 (n = 25) breast cancer were treated and followed up for an average of 39 months. Only 3% (1/34) patients experienced a grade 3 subcutaneous fibrosis and breast edema and 97% of the patients had good/excellent cosmetic outcome at 3 years. The 3-year rate of ipsilateral breast tumor recurrence (IBTR) was 0% while the rate of contralateral breast events was 6%. The 3-year disease-free survival (DFS), overall survival (OS), and breast cancer-specific survival (BCSS) was 94%, 100%, and 100%, respectively. Our novel accelerated partial breast fractionation scheme of 15 once daily fractions of 3.33 Gy (49.95 Gy total) is a remarkably well-tolerated regimen of 3D-CRT-based APBI. A larger cohort of patients is needed to further ascertain the toxicity of this accelerated partial breast regimen. PMID:24403270

  2. Global intensification in observed short-duration rainfall extremes

    NASA Astrophysics Data System (ADS)

    Fowler, H. J.; Lewis, E.; Guerreiro, S.; Blenkinsop, S.; Barbero, R.; Westra, S.; Lenderink, G.; Li, X.

    2017-12-01

    Extreme rainfall events are expected to intensify with a warming climate and this is currently driving extensive research. While daily rainfall extremes are widely thought to have increased globally in recent decades, changes in rainfall extremes on shorter timescales, often associated with flash flooding, have not been documented at global scale due to surface observational limitations and the lack of a global sub-daily rainfall database. The access to and use of such data remains a challenge. For the first time, we have synthesized across multiple data sources providing gauge-based sub-daily rainfall observations across the globe over the last 6 decades. This forms part of the INTENSE project (part of the World Climate Research Programme (WCRP)'s Grand Challenge on 'Understanding and Predicting Weather and Climate Extremes' and the Global Water and Energy Exchanges (GEWEX) Hydroclimate Project cross-cut on sub-daily rainfall). A set of global hydroclimatic indices have been produced based upon stakeholder recommendations including indices that describe maximum rainfall totals and timing, the intensity, duration and frequency of storms, frequency of storms above specific thresholds and information about the diurnal cycle. This will provide a unique global data resource on sub-daily precipitation whose derived indices will be freely available to the wider scientific community. Because of the physical connection between global warming and the moisture budget, we also sought to infer long-term changes in sub-daily rainfall extremes contingent on global mean temperature. Whereas the potential influence of global warming is uncertain at regional scales, where natural variability dominates, aggregating surface stations across parts of the world may increase the global warming-induced signal. Changes in terms of annual maximum rainfall across various resolutions ranging from 1-h to 24-h are presented and discussed.

  3. Effects of recombinant human granulocyte colony-stimulating factor on the hematologic recovery and survival of irradiated mice

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Tanikawa, S.; Nose, M.; Aoki, Y.

    1990-08-01

    We studied the effects of intraperitoneal injections of recombinant human granulocyte colony-stimulating factor (rhG-CSF) according to various administration schedules on the recovery of spleen colony-forming units (CFU-S) and peripheral blood counts, and on the survival of irradiated mice. The sooner and more frequently the mice were injected with rhG-CSF after irradiation, the more enhanced the recovery of CFU-S in bone marrow was obtained on day 7. Twice-daily injections of rhG-CSF from day 0 to day 2 significantly enhanced the recovery of platelets and hematocrit, but two injections of rhG-CSF on only day 0 did not. Twice-daily injections of rhG-CSF frommore » day 0 to day 6 enhanced the recovery of platelets more effectively than twice-daily injections of rhG-CSF from day 1 to day 7, and increased the survival of irradiated mice more effectively than any other examined administration schedules. Twice-daily injections of rhG-CSF from day 0 to day 6 were significantly effective in enhancing the survival of mice irradiated with 8.5-, 9.0-, and 9.5-Gy x-rays, although not effective after irradiation of 10.5-Gy x-rays.« less

  4. Solar Irradiance Data Products at the LASP Interactive Solar IRradiance Datacenter (LISIRD)

    NASA Astrophysics Data System (ADS)

    Ware Dewolfe, A.; Wilson, A.; Lindholm, D. M.; Pankratz, C. K.; Snow, M. A.; Woods, T. N.

    2010-12-01

    The Laboratory for Atmospheric and Space Physics (LASP) has developed the LASP Interactive Solar IRradiance Datacenter (LISIRD) to provide access to a comprehensive set of solar irradiance measurements. LISIRD has recently been updated to serve many new datasets and models, including data from SORCE, UARS-SOLSTICE, SME, and TIMED-SEE, and model data from the Flare Irradiance Spectral Model (FISM). The user interface emphasizes web-based interactive visualizations, allowing users to explore and compare this data before downloading it for analysis. The data provided covers a wavelength range from soft X-ray (XUV) at 0.1 nm up to the near infrared (NIR) at 2400 nm, as well as wavelength-independent Total Solar Irradiance (TSI). Combined data from the SORCE, TIMED-SEE, UARS-SOLSTICE, and SME instruments provide continuous coverage from 1981 to the present, while Lyman-alpha measurements, FISM daily data, and TSI models date from the 1940s to the present. LISIRD will also host Glory TSI data as part of the SORCE data system. This poster provides an overview of the LISIRD system, summarizes the data sets currently available, describes future plans and capabilities, and provides details on how to access solar irradiance data through LISIRD’s interfaces.

  5. Age differences in emotional responses to daily stress: the role of timing, severity, and global perceived stress.

    PubMed

    Scott, Stacey B; Sliwinski, Martin J; Blanchard-Fields, Fredda

    2013-12-01

    Research on age differences in emotional responses to daily stress has produced inconsistent findings. Guided by recent theoretical advances in aging theory (S. T. Charles, 2010, Strength and vulnerability integration: A model of emotional well-being across adulthood, Psychological Bulletin, Vol. 136, pp. 1068-1091) that emphasize the importance of context for predicting when and how age is related to affective well-being, the current study examined age differences in emotional responses to everyday stressors. The present study examined how three contextual features (e.g., timing of exposure, stressor severity, global perceived stress [GPS]) moderate age differences in emotional experience in an ecological momentary assessment study of adults (N = 190) aged 18-81 years. Results indicated that older adults' negative affect (NA) was less affected by exposure to recent stressors than younger adults, but that there were no age differences in the effects of stressor exposure 3-6 hr afterward. Higher levels of GPS predicted amplified NA responses to daily stress, and controlling for GPS eliminated age differences in NA responses to stressors. No age differences in NA responses as a function of stressor severity were observed. In contrast, older age was associated with less of a decrease in PA when exposed to recent stressors or with more severe recent stressors. There were no age differences in the effect of previous stressor exposure or severity on PA, or any interactions between momentary or previous stress and GPS on PA. Together, these results support the notion that chronic stress plays a central role in emotional experience in daily life. We discuss the implications of these results for emotion theories of aging. PsycINFO Database Record (c) 2013 APA, all rights reserved.

  6. Study of the biochemical indicators of chronic irradiation in rats.

    PubMed

    Szabo, L D; Benko, A B; Gyenge, L; Predmerszky, T

    1976-01-01

    Daily urinary excretion of pseudouridine, creatinine and creatine of chronically irradiated Wistar rats was estimated. The irradiation conditions were: 60Co gamma source, dose-rate 10 rad/day, total dose 200, 400 and 600 rad. Control groups were kept under similar conditions. Urine samples were taken three times after the end of the irradiation period. It was found that: (1) pseudouridine excretion seems more suitable for indicating radiation injury than the creatine/creatinine ratio in chronic irradiation in rats; (ii) there are significant changes in dose dependence of pseudouridine excretion in the post-irradiation period; (iii) a new method for pseudouridine estimation gives closely similar data to those of earlier investigations.

  7. Patterns and Variability in Global Ocean Chlorophyll: Satellite Observations and Modeling

    NASA Technical Reports Server (NTRS)

    Gregg, Watson

    2004-01-01

    Recent analyses of SeaWiFS data have shown that global ocean chlorophyll has increased more than 4% since 1998. The North Pacific ocean basin has increased nearly 19%. These trend analyses follow earlier results showing decadal declines in global ocean chlorophyll and primary production. To understand the causes of these changes and trends we have applied the newly developed NASA Ocean Biogeochemical Assimilation Model (OBAM), which is driven in mechanistic fashion by surface winds, sea surface temperature, atmospheric iron deposition, sea ice, and surface irradiance. The model utilizes chlorophyll from SeaWiFS in a daily assimilation. The model has in place many of the climatic variables that can be expected to produce the changes observed in SeaWiFS data. This enables us to diagnose the model performance, the assimilation performance, and possible causes for the increase in chlorophyll. A full discussion of the changes and trends, possible causes, modeling approaches, and data assimilation will be the focus of the seminar.

  8. Influence of synoptic weather patterns on solar irradiance variability in Europe

    NASA Astrophysics Data System (ADS)

    Parding, Kajsa; Hinkelman, Laura; Liepert, Beate; Ackerman, Thomas; Dagestad, Knut-Frode; Asle Olseth, Jan

    2014-05-01

    Solar radiation is important for many aspects of existence on Earth, including the biosphere, the hydrological cycle, and creatures living on the planet. Previous studies have reported decadal trends in observational records of surface shortwave (SW) irradiance around the world, too strong to be caused by varying solar output. These observed decadal trends have been dubbed "solar dimming and brightening" and are believed to be related to changes in atmospheric aerosols and cloud cover. Because the observed solar variability coincides with qualitative air pollution histories, the dimming and brightening have become almost synonymous with shortwave attenuation by anthropogenic aerosols. However, there are indications that atmospheric circulation patterns have influenced the dimming and brightening in some regions, e.g., Alaska and Scandinavia. In this work, we focus on the role of atmospheric circulation patterns in modifying shortwave irradiance. An examination of European SW irradiance data from the Global Energy Balance Archive (GEBA) shows that while there are periods of predominantly decreasing (~1970-1985) and increasing (~1985-2007) SW irradiance, the changes are not spatially uniform within Europe and in a majority of locations not statistically significant. To establish a connection between weather patterns and sunshine, regression models of SW irradiance are fitted using a daily classification of European weather called Grosswetterlagen (GWL). The GWL reconstructions of shortwave irradiance represent the part of the solar variability that is related to large scale weather patterns, which should be effectively separated from the influence of varying anthropogenic aerosol emissions. The correlation (R) between observed and reconstruced SW irradiance is between 0.31 and 0.75, depending on station and season, all statistically significant (p<0.05, estimated with a bootstrap test). In central and eastern parts of Europe, the observed decadal SW variability is

  9. Phytosanitary irradiation and fresh fruit quality: Cultivar and maturity effects

    USDA-ARS?s Scientific Manuscript database

    Irradiation is an effective quarantine treatment for global trade of fresh produce. Variation in cultivars and maturity stages can impact the tolerance of fresh fruits to irradiation for the purposes of quarantine security. Tolerance thresholds for irradiated fruit are lacking for a large number of ...

  10. Recent advances in satellite observations of solar variability and global atmospheric ozone

    NASA Technical Reports Server (NTRS)

    Heath, D. F.

    1974-01-01

    A description is given of the temporal behavior of the sun as an ultraviolet variable star in relation to daily zonal means of atmospheric ozone from the total amount to that above the 10-mb and 4-mb pressure levels. A significant correlation has been observed between enhancements in the ultraviolet solar irradiances and terrestrial passages of the solar magnetic field sector boundary structure. However, it has not yet been possible to separate solar from the dynamical effects on the variability in the zonal means of ozone. Attention is given to global changes in ozone which have been derived from the satellite observations in terms of season, solar variability, and major stratospheric disturbances such as stratospheric warmings.

  11. Total solar irradiance reconstruction since 1700 using a flux transport model

    NASA Astrophysics Data System (ADS)

    Dasi Espuig, Maria; Krivova, Natalie; Solanki, Sami K.; Jiang, Jie

    Reconstructions of solar irradiance into the past are crucial for studies of solar influence on climate. Models based on the assumption that irradiance changes are caused by the evolution of the photospheric magnetic fields have been most successful in reproducing the measured irradiance variations. Daily magnetograms, such as those from MDI and HMI, provide the most detailed information on the changing distribution of the photospheric magnetic fields. Since such magnetograms are only available from 1974, we used a surface flux transport model to describe the evolution of the magnetic fields on the solar surface due to the effects of differential rotation, meridional circulation, and turbulent diffusivity, before 1974. In this model, the sources of magnetic flux are the active regions, which are introduced based on sunspot group areas, positions, and tilt angles. The RGO record is, however, only available since 1874. Here we present a model of solar irradiance since 1700, which is based on a semi-synthetic sunspot record. The semi-synthetic record was obtained using statistical relationships between sunspot group properties (areas, positions, tilt angles) derived from the RGO record on one hand, and the cycle strength and phase derived from the sunspot group number (Rg) on the other. These relationships were employed to produce daily records of sunspot group positions, areas, and tilt angles before 1874. The semi-synthetic records were fed into the surface flux transport model to simulate daily magnetograms since 1700. By combining the simulated magnetograms with a SATIRE-type model, we then reconstructed total solar irradiance since 1700.

  12. Advanced solar irradiances applied to satellite and ionospheric operational systems

    NASA Astrophysics Data System (ADS)

    Tobiska, W. Kent; Schunk, Robert; Eccles, Vince; Bouwer, Dave

    Satellite and ionospheric operational systems require solar irradiances in a variety of time scales and spectral formats. We describe the development of a system using operational grade solar irradiances that are applied to empirical thermospheric density models and physics-based ionospheric models used by operational systems that require a space weather characterization. The SOLAR2000 (S2K) and SOLARFLARE (SFLR) models developed by Space Environment Technologies (SET) provide solar irradiances from the soft X-rays (XUV) through the Far Ultraviolet (FUV) spectrum. The irradiances are provided as integrated indices for the JB2006 empirical atmosphere density models and as line/band spectral irradiances for the physics-based Ionosphere Forecast Model (IFM) developed by the Space Environment Corporation (SEC). We describe the integration of these irradiances in historical, current epoch, and forecast modes through the Communication Alert and Prediction System (CAPS). CAPS provides real-time and forecast HF radio availability for global and regional users and global total electron content (TEC) conditions.

  13. Level 4 Global and European Chl-a Daily Analyses for End Users and Data Assimilation in the Frame of the Copernicus-Marine Environment Monitoring Service

    NASA Astrophysics Data System (ADS)

    Saulquin, Bertrand; Gohin, Francis; Garnesson, Philippe; Demaria, Julien; Mangin, Antoine; Fanton d'Andon, Odile

    2016-08-01

    The level-4 daily chl-a products are a combination of a water typed merge of chl-a estimates and an optimal interpolation based on the kriging method with regional anisotropic models [1, 2]. The Level 4 products basically pro- vide a global continuous (cloud free) estimation of the surface chl-a concentration at 4 km resolution over the world and 1 km resolution over the Europe. The level-4 products gather MODIS, MERIS, SeaWiFS, VIIRS and OLCI daily observations from 1998 to now.The Level 4 product avoids end users to consider typical lack of data as observed during cloudy conditions and the historical multiplicity of available algorithms such as involved by case 1 (oligotrophic) and case 2 (turbid) water issues in ocean colour. [3, 4].A total product uncertainty, i.e. a combination of the interpolation and the estimation error, is provided for each daily product. The L4 products are freely distributed in the frame of the Copernicus - Marine environment monitoring service.

  14. Phytosanitary irradiation - Development and application

    NASA Astrophysics Data System (ADS)

    Hallman, Guy J.; Loaharanu, Paisan

    2016-12-01

    Phytosanitary irradiation, the use of ionizing radiation to disinfest traded agricultural commodities of regulated pests, is a growing use of food irradiation that has great continued potential for increase in commercial application. In 2015 approximately 25,000 t of fresh fruits and vegetables were irradiated globally for phytosanitary purposes. Phytosanitary irradiation has resulted in a paradigm shift in phytosanitation in that the final burden of proof of efficacy of the treatment has shifted from no live pests upon inspection at a port of entry (as for all previous phytosanitary treatments) to total dependence on certification that the treatment for target pests is based on adequate science and is commercially conducted and protected from post-treatment infestation. In this regard phytosanitary irradiation is managed more like a hazard analysis and critical control point (HACCP) approach more consistent with food safety than phytosanitation. Thus, phytosanitary irradiation offers a more complete and rigorous methodology for safeguarding than other phytosanitary measures. The role of different organizations in achieving commercial application of phytosanitary irradiation is discussed as well as future issues and applications, including new generic doses.

  15. Solar EUV irradiance for space weather applications

    NASA Astrophysics Data System (ADS)

    Viereck, R. A.

    2015-12-01

    Solar EUV irradiance is an important driver of space weather models. Large changes in EUV and x-ray irradiances create large variability in the ionosphere and thermosphere. Proxies such as the F10.7 cm radio flux, have provided reasonable estimates of the EUV flux but as the space weather models become more accurate and the demands of the customers become more stringent, proxies are no longer adequate. Furthermore, proxies are often provided only on a daily basis and shorter time scales are becoming important. Also, there is a growing need for multi-day forecasts of solar EUV irradiance to drive space weather forecast models. In this presentation we will describe the needs and requirements for solar EUV irradiance information from the space weather modeler's perspective. We will then translate these requirements into solar observational requirements such as spectral resolution and irradiance accuracy. We will also describe the activities at NOAA to provide long-term solar EUV irradiance observations and derived products that are needed for real-time space weather modeling.

  16. MISR L3 Global Products

    Atmospheric Science Data Center

    2016-10-31

    Global Products The MISR Level 3 Products are global or regional maps of select parameters from the Level 2 products and ... from multiple orbits are combined to make complete Level 3 global maps at daily (D), monthly (M), quarterly (Q), and yearly (Y) time ...

  17. Spatial And Temporal Patterns As Well As Major Influencing Factors Of Global And Diffuse Horizontal Irradiance Over China: 1960-2014

    NASA Astrophysics Data System (ADS)

    Wang, H.; Sun, F.

    2017-12-01

    Global Horizontal Irradiance (GHI) on Earth is a central element of climate systems. With changes in the climate and regional development, the patterns and influencing factors of GHI, in addition to presenting global consistency, are increasingly showing regional particularities. Based on data for GHI, Diffuse Horizontal Irradiance (DHI) and potential impact factors (geographical position, elevation, cloud cover, water vapor, and ground atmospheric transparency related variables) from 1960 to 2014 in China, we analyzed the pattern and major influencing factors of GHI and DHI. The results showed that the major influencing factors of the GHI spatial pattern were the total cloud cover (TCC) and relative humidity (RH) in China. Dividing all of China into two regions, the major factors were the water vapor pressure (WVP) in the northern region and TCC in the southern region. And we divided the GHI and DHI data into two periods (1960-1987 and 1988-2014) due to global dimming and brightening observed in China in the late 1980's. The temporal GHI showed that 31 of 58 decreased significantly with an average decreasing rate of 95 MJ.10yr-1 during the periods of 1960-2014 and 49 of 76 stations decreased significantly with an rate of 342 MJ.10yr-1 during 1960-1987, whereas 57 of 88 stations did not change and 24 stations increased significantly with an rate of 201 MJ.10yr-1 during the period of 1988-2014. The temporal DHI showed that 40 of 61sites did not change significantly from 1960 to 1987. The major influencing factors for temporal changes of GHI in nine typical cities from 1960 to 2013 were as follows: air quality-related variables in super cities, sandstorms and wind in desert oasis cities, clouds in cities with good air quality and a low cloud amount (LCA) and annual fog days (FD) in Chengdu. Overall, we identified characteristics of GHI and DHI based on global climate change and regional urban development and found that the spatial characteristics of GHI results for

  18. Photosynthesis-irradiance parameters of marine phytoplankton: synthesis of a global data set

    NASA Astrophysics Data System (ADS)

    Bouman, Heather A.; Platt, Trevor; Doblin, Martina; Figueiras, Francisco G.; Gudmundsson, Kristinn; Gudfinnsson, Hafsteinn G.; Huang, Bangqin; Hickman, Anna; Hiscock, Michael; Jackson, Thomas; Lutz, Vivian A.; Mélin, Frédéric; Rey, Francisco; Pepin, Pierre; Segura, Valeria; Tilstone, Gavin H.; van Dongen-Vogels, Virginie; Sathyendranath, Shubha

    2018-02-01

    The photosynthetic performance of marine phytoplankton varies in response to a variety of factors, environmental and taxonomic. One of the aims of the MArine primary Production: model Parameters from Space (MAPPS) project of the European Space Agency is to assemble a global database of photosynthesis-irradiance (P-E) parameters from a range of oceanographic regimes as an aid to examining the basin-scale variability in the photophysiological response of marine phytoplankton and to use this information to improve the assignment of P-E parameters in the estimation of global marine primary production using satellite data. The MAPPS P-E database, which consists of over 5000 P-E experiments, provides information on the spatio-temporal variability in the two P-E parameters (the assimilation number, PmB, and the initial slope, αB, where the superscripts B indicate normalisation to concentration of chlorophyll) that are fundamental inputs for models (satellite-based and otherwise) of marine primary production that use chlorophyll as the state variable. Quality-control measures consisted of removing samples with abnormally high parameter values and flags were added to denote whether the spectral quality of the incubator lamp was used to calculate a broad-band value of αB. The MAPPS database provides a photophysiological data set that is unprecedented in number of observations and in spatial coverage. The database will be useful to a variety of research communities, including marine ecologists, biogeochemical modellers, remote-sensing scientists and algal physiologists. The compiled data are available at https://doi.org/10.1594/PANGAEA.874087 (Bouman et al., 2017).

  19. A randomized, single-blind trial of 5% minoxidil foam once daily versus 2% minoxidil solution twice daily in the treatment of androgenetic alopecia in women.

    PubMed

    Blume-Peytavi, Ulrike; Hillmann, Kathrin; Dietz, Ekkehart; Canfield, Douglas; Garcia Bartels, Natalie

    2011-12-01

    Although twice-daily application of propylene glycol-containing 2% minoxidil topical solution (MTS) stimulates new hair growth, higher concentrations of minoxidil in a once-daily, propylene glycol-free formulation may improve efficacy and reduce unpleasant side effects. We sought to compare the efficacy, safety, and acceptability and to show noninferiority of once-daily 5% minoxidil topical foam (MTF) with twice-daily 2% MTS in women with androgenetic alopecia. A total of 113 women with androgenetic alopecia were randomized to 24 weeks of treatment with 5% MTF or 2% MTS. The primary efficacy parameter was change from baseline in nonvellus target area hair count at week 24. Secondary end points included change in nonvellus target area hair width, overall efficacy by global photographic review as assessed by treatment-blinded evaluators and the subject herself, adverse events, and participants' assessment of product aesthetics. After 24 weeks, women randomized to 5% MTF once daily showed noninferior target area hair count and target area hair width and experienced greater, but nonsignificant, improvements in target area hair count, target area hair width, and overall efficacy by global photographic review than those randomized to 2% MTS used twice daily. 5% MTF was significantly superior to 2% MTS in participants' agreement with "the treatment does not interfere with styling my hair" (P = .002). Women randomized to 5% MTF experienced significantly lower rates of local intolerance (P = .046) especially in pruritus and dandruff compared with 2% MTS. Because of differences in the formulations tested, study participants were not blinded to treatment. Once-daily 5% MTF is noninferior and as effective for stimulating hair growth as twice-daily 2% MTS in women with androgenetic alopecia and is associated with several aesthetic and practical advantages. Copyright © 2010 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.

  20. Forecasting Global Horizontal Irradiance Using the LETKF and a Combination of Advected Satellite Images and Sparse Ground Sensors

    NASA Astrophysics Data System (ADS)

    Harty, T. M.; Lorenzo, A.; Holmgren, W.; Morzfeld, M.

    2017-12-01

    The irradiance incident on a solar panel is the main factor in determining the power output of that panel. For this reason, accurate global horizontal irradiance (GHI) estimates and forecasts are critical when determining the optimal location for a solar power plant, forecasting utility scale solar power production, or forecasting distributed, behind the meter rooftop solar power production. Satellite images provide a basis for producing the GHI estimates needed to undertake these objectives. The focus of this work is to combine satellite derived GHI estimates with ground sensor measurements and an advection model. The idea is to use accurate but sparsely distributed ground sensors to improve satellite derived GHI estimates which can cover large areas (the size of a city or a region of the United States). We use a Bayesian framework to perform the data assimilation, which enables us to produce irradiance forecasts and associated uncertainties which incorporate both satellite and ground sensor data. Within this framework, we utilize satellite images taken from the GOES-15 geostationary satellite (available every 15-30 minutes) as well as ground data taken from irradiance sensors and rooftop solar arrays (available every 5 minutes). The advection model, driven by wind forecasts from a numerical weather model, simulates cloud motion between measurements. We use the Local Ensemble Transform Kalman Filter (LETKF) to perform the data assimilation. We present preliminary results towards making such a system useful in an operational context. We explain how localization and inflation in the LETKF, perturbations of wind-fields, and random perturbations of the advection model, affect the accuracy of our estimates and forecasts. We present experiments showing the accuracy of our forecasted GHI over forecast-horizons of 15 mins to 1 hr. The limitations of our approach and future improvements are also discussed.

  1. The effects of sunspots on solar irradiance

    NASA Technical Reports Server (NTRS)

    Hudson, H. S.; Silva, S.; Woodard, M.; Willson, R. C.

    1982-01-01

    It is pointed out that the darkness of a sunspot on the visible hemisphere of the sun will reduce the solar irradiance on the earth. Approaches are discussed for obtaining a crude estimate of the irradiance deficit produced by sunspots and of the total luminosity reduction for the whole global population of sunspots. Attention is given to a photometric sunspot index, a global measure of spot flux deficit, and models for the compensating flux excess. A model is shown for extrapolating visible-hemisphere spot areas to the invisible hemisphere. As an illustration, this extrapolation is used to calculate a very simple model for the reradiation necessary to balance the flux deficit.

  2. Short-Term Global Horizontal Irradiance Forecasting Based on Sky Imaging and Pattern Recognition

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hodge, Brian S; Feng, Cong; Cui, Mingjian

    Accurate short-term forecasting is crucial for solar integration in the power grid. In this paper, a classification forecasting framework based on pattern recognition is developed for 1-hour-ahead global horizontal irradiance (GHI) forecasting. Three sets of models in the forecasting framework are trained by the data partitioned from the preprocessing analysis. The first two sets of models forecast GHI for the first four daylight hours of each day. Then the GHI values in the remaining hours are forecasted by an optimal machine learning model determined based on a weather pattern classification model in the third model set. The weather pattern ismore » determined by a support vector machine (SVM) classifier. The developed framework is validated by the GHI and sky imaging data from the National Renewable Energy Laboratory (NREL). Results show that the developed short-term forecasting framework outperforms the persistence benchmark by 16% in terms of the normalized mean absolute error and 25% in terms of the normalized root mean square error.« less

  3. Drinking-to-cope motivation and negative mood-drinking contingencies in a daily diary study of college students.

    PubMed

    O'Hara, Ross E; Armeli, Stephen; Tennen, Howard

    2014-07-01

    This study examined whether global drinking-to-cope (DTC) motivation moderates negative mood-drinking contingencies and negative mood-motivation contingencies at the daily level of analysis. Data came from a daily diary study of college student drinking (N = 1,636; 53% female; Mage = 19.2 years). Fixed-interval models tested whether global DTC motivation moderated relations between daily negative mood and that evening's drinking and episodic DTC. Time-to-drink models examined whether global DTC motivation moderated the effects of weekly negative mood on the immediacy of drinking and DTC in the weekly cycle. More evening drinking occurred on days characterized by relatively higher anxiety or anger, and students were more likely to report DTC on days when they experienced greater sadness. However, only the daily Anxiety × Global DTC Motivation interaction for number of drinks consumed was consistent with hypotheses. Moreover, students reported drinking, heavy drinking, and DTC earlier in weeks characterized by relatively higher anxiety or anger, but no hypothesized interactions with global DTC motivation were found. RESULTS indicate that negative mood is associated with increased levels of drinking and drinking for coping reasons among college students but that the strength of these relations does not differ by global levels of DTC motivation. These findings raise the possibility that global DTC measures are insufficient for examining within-person DTC processes. Further implications of these results are discussed, including future directions that may determine the circumstances under which, and for whom, DTC occurs.

  4. Uncertainty Estimate of Surface Irradiances Computed with MODIS-, CALIPSO-, and CloudSat-Derived Cloud and Aerosol Properties

    NASA Astrophysics Data System (ADS)

    Kato, Seiji; Loeb, Norman G.; Rutan, David A.; Rose, Fred G.; Sun-Mack, Sunny; Miller, Walter F.; Chen, Yan

    2012-07-01

    Differences of modeled surface upward and downward longwave and shortwave irradiances are calculated using modeled irradiance computed with active sensor-derived and passive sensor-derived cloud and aerosol properties. The irradiance differences are calculated for various temporal and spatial scales, monthly gridded, monthly zonal, monthly global, and annual global. Using the irradiance differences, the uncertainty of surface irradiances is estimated. The uncertainty (1σ) of the annual global surface downward longwave and shortwave is, respectively, 7 W m-2 (out of 345 W m-2) and 4 W m-2 (out of 192 W m-2), after known bias errors are removed. Similarly, the uncertainty of the annual global surface upward longwave and shortwave is, respectively, 3 W m-2 (out of 398 W m-2) and 3 W m-2 (out of 23 W m-2). The uncertainty is for modeled irradiances computed using cloud properties derived from imagers on a sun-synchronous orbit that covers the globe every day (e.g., moderate-resolution imaging spectrometer) or modeled irradiances computed for nadir view only active sensors on a sun-synchronous orbit such as Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observation and CloudSat. If we assume that longwave and shortwave uncertainties are independent of each other, but up- and downward components are correlated with each other, the uncertainty in global annual mean net surface irradiance is 12 W m-2. One-sigma uncertainty bounds of the satellite-based net surface irradiance are 106 W m-2 and 130 W m-2.

  5. Ship-borne measurements of erythemal UV irradiance and ozone content in various climate zones.

    PubMed

    Wuttke, Sigrid; El Naggar, Saad; Bluszcz, Thaddäus; Schrems, Otto

    2007-10-01

    Ship-borne measurements of spectral as well as biologically effective UV irradiance have been performed on the German research vessel Polarstern during the Atlantic transect from Bremerhaven, Germany (53.5 degrees N, 8.5 degrees E), to Cape Town, South Africa (33.6 degrees S, 18.3 degrees E), from 13 October to 17 November 2005. Such measurements are required to study UV effects on marine organisms. They are also necessary to validate satellite-derived surface UV irradiance. Cloud free radiative transfer calculations support the investigation of this latitudinal dependence. Input parameters, such as total ozone column and aerosol optical depth have been measured on board as well. Using these measured parameters, the modelled cloudless noontime UVA irradiance (320-400 nm) shows the expected dependence on varying minimum solar zenith angles (SZA) at different latitudes. The modelled cloudless noontime UVB irradiance (290-320 nm) does not show this clear dependence on SZA due to the strong influence of ozone absorption in this spectral range. The maximum daily dose of erythemal irradiance of 5420 J m(-1) was observed on 14 November 2005, when the ship was in the tropical Atlantic south of the equator. The expected UV maximum should have been observed with the sun in the zenith during local noon (11 November). Stratiform clouds reduced the dose to 3835 J m(-1). In comparison, the daily erythemal doses in the mid-latitudinal Bay of Biscay only reached values between 410 and 980 J m(-1) depending on cloud conditions. The deviation in daily erythemal dose derived from different instruments is around 5%. The feasibility to perform ship-borne measurements of spectral UV irradiance is demonstrated.

  6. Modeling the relationship between photosynthetically active radiation and global horizontal irradiance using singular spectrum analysis

    NASA Astrophysics Data System (ADS)

    Zempila, Melina-Maria; Taylor, Michael; Bais, Alkiviadis; Kazadzis, Stelios

    2016-10-01

    We report on the construction of generic models to calculate photosynthetically active radiation (PAR) from global horizontal irradiance (GHI), and vice versa. Our study took place at stations of the Greek UV network (UVNET) and the Hellenic solar energy network (HNSE) with measurements from NILU-UV multi-filter radiometers and CM pyranometers, chosen due to their long (≈1 M record/site) high temporal resolution (≈1 min) record that captures a broad range of atmospheric environments and cloudiness conditions. The uncertainty of the PAR measurements is quantified to be ±6.5% while the uncertainty involved in GHI measurements is up to ≈±7% according to the manufacturer. We show how multi-linear regression and nonlinear neural network (NN) models, trained at a calibration site (Thessaloniki) can be made generic provided that the input-output time series are processed with multi-channel singular spectrum analysis (M-SSA). Without M-SSA, both linear and nonlinear models perform well only locally. M-SSA with 50 time-lags is found to be sufficient for identification of trend, periodic and noise components in aerosol, cloud parameters and irradiance, and to construct regularized noise models of PAR from GHI irradiances. Reconstructed PAR and GHI time series capture ≈95% of the variance of the cross-validated target measurements and have median absolute percentage errors <2%. The intra-site median absolute error of M-SSA processed models were ≈8.2±1.7 W/m2 for PAR and ≈9.2±4.2 W/m2 for GHI. When applying the models trained at Thessaloniki to other stations, the average absolute mean bias between the model estimates and measured values was found to be ≈1.2 W/m2 for PAR and ≈0.8 W/m2 for GHI. For the models, percentage errors are well within the uncertainty of the measurements at all sites. Generic NN models were found to perform marginally better than their linear counterparts.

  7. Significance of Fractionated Administration of Thalidomide Combined With γ-Ray Irradiation in Terms of Local Tumor Response and Lung Metastasis

    PubMed Central

    Masunaga, Shin-ichiro; Sanada, Yu; Moriwaki, Takahiro; Tano, Keizo; Sakurai, Yoshinori; Tanaka, Hiroki; Suzuki, Minoru; Kondo, Natsuko; Narabayashi, Masaru; Watanabe, Tsubasa; Nakagawa, Yosuke; Maruhashi, Akira; Ono, Koji

    2014-01-01

    Background The aim of this study was to evaluate the significance of fractionated administration of thalidomide combined with γ-ray irradiation in terms of local tumor response and lung metastatic potential, referring to the response of intratumor quiescent (Q) cells. Methods B16-BL6 melanoma tumor-bearing C57BL/6 mice were continuously given 5-bromo-2’-deoxyuridine (BrdU) to label all proliferating (P) cells. The tumor-bearing mice then received γ-ray irradiation after thalidomide treatment through a single or two consecutive daily intraperitoneal administrations up to a total dose of 400 mg/kg in combination with an acute hypoxia-releasing agent (nicotinamide) or mild temperature hyperthermia (MTH). Immediately after the irradiation, cells from some tumors were isolated and incubated with a cytokinesis blocker. The responses of the Q and total (= P + Q) cell populations were assessed based on the frequency of micronuclei using immunofluorescence staining for BrdU. In other tumor-bearing mice, 17 days after irradiation, macroscopic lung metastases were enumerated. Results Thalidomide raised the sensitivity of the total cell population more remarkably than Q cells in both single and daily administrations. Daily administration of thalidomide elevated the sensitivity of both the total and Q cell populations, but especially the total cell population, compared with single administration. Daily administration, especially combined with MTH, decreased the number of lung metastases. Conclusion Daily fractionated administration of thalidomide in combination with γ-ray irradiation was thought to be more promising than single administration because of its potential to enhance local tumor response and repress lung metastatic potential. PMID:29147396

  8. Modelling total solar irradiance using a flux transport model

    NASA Astrophysics Data System (ADS)

    Dasi Espuig, Maria; Jiang, Jie; Krivova, Natalie; Solanki, Sami

    2014-05-01

    Reconstructions of solar irradiance into the past are of considerable interest for studies of solar influence on climate. Models based on the assumption that irradiance changes are caused by the evolution of the photospheric magnetic field have been the most successful in reproducing the measured irradiance variations. Our SATIRE-S model is one of these. It uses solar full-disc magnetograms as an input, and these are available for less than four decades. Thus, to reconstruct the irradiance back to times when no observed magnetograms are available, we combine the SATIRE-S model with synthetic magnetograms, produced using a surface flux transport model. The model is fed with daily, observed or modelled statistically, records of sunspot positions, areas, and tilt angles. To describe the secular change in the irradiance, we used the concept of overlapping ephemeral region cycles. With this technique TSI can be reconstructed back to 1700.

  9. Energetics of global ocean tides from Geosat altimetry

    NASA Technical Reports Server (NTRS)

    Cartwright, David E.; Ray, Richard D.

    1991-01-01

    The present paper focuses on resonance and energetics of the daily tides, especially in the southern ocean, the distribution of gravitational power input of daily and half-daily tides, and comparison with other estimates of global dissipation rates. The present global tidal maps, derived from Geosat altimetry, compare favorably with ground truth data at about the same rms level as the models of Schwiderski (1983), and are slightly better in lunar than in solar tides. Diurnal admittances clearly show Kelvin wave structure in the southern ocean and confirm the resonant mode of Platzman (1984) at 28.5 + or - 0.1 hr with an apparent Q of about 4. Driving energy is found to enter dominantly in the North Pacific for the daily tides and is strongly peaked in the tropical oceans for the half-daily tides. Global rates of working on all major tide constituents except S2 agree well with independent results from analyses of gravity through satellite tracking. Comparison at S2 is improved by allowing for the air tide in gravitational results but suggests deficiencies in all solar tide models.

  10. Larval x-ray irradiation influences protein expression in pupae of the Oriental fruit fly, Bactrocera Dorsalis

    USDA-ARS?s Scientific Manuscript database

    Third instar larvae were exposed to X-ray treatment of the Oriental fruit fly, Bactrocera dorsalis. Irradiated pupae were collected daily. Biological performance parameters of pupae and adults of larvae treated with X-ray irradiation were evaluated. Standard proteomics procedures such as densitometr...

  11. Improvements of top-of-atmosphere and surface irradiance computations with CALIPSO-, CloudSat-, and MODIS-derived cloud and aerosol properties

    NASA Astrophysics Data System (ADS)

    Kato, Seiji; Rose, Fred G.; Sun-Mack, Sunny; Miller, Walter F.; Chen, Yan; Rutan, David A.; Stephens, Graeme L.; Loeb, Norman G.; Minnis, Patrick; Wielicki, Bruce A.; Winker, David M.; Charlock, Thomas P.; Stackhouse, Paul W., Jr.; Xu, Kuan-Man; Collins, William D.

    2011-10-01

    One year of instantaneous top-of-atmosphere (TOA) and surface shortwave and longwave irradiances are computed using cloud and aerosol properties derived from instruments on the A-Train Constellation: the Cloud-Aerosol Lidar with Orthogonal Polarization (CALIOP) on the Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observation (CALIPSO) satellite, the CloudSat Cloud Profiling Radar (CPR), and the Aqua Moderate Resolution Imaging Spectrometer (MODIS). When modeled irradiances are compared with those computed with cloud properties derived from MODIS radiances by a Clouds and the Earth's Radiant Energy System (CERES) cloud algorithm, the global and annual mean of modeled instantaneous TOA irradiances decreases by 12.5 W m-2 (5.0%) for reflected shortwave and 2.5 W m-2 (1.1%) for longwave irradiances. As a result, the global annual mean of instantaneous TOA irradiances agrees better with CERES-derived irradiances to within 0.5W m-2 (out of 237.8 W m-2) for reflected shortwave and 2.6W m-2 (out of 240.1 W m-2) for longwave irradiances. In addition, the global annual mean of instantaneous surface downward longwave irradiances increases by 3.6 W m-2 (1.0%) when CALIOP- and CPR-derived cloud properties are used. The global annual mean of instantaneous surface downward shortwave irradiances also increases by 8.6 W m-2 (1.6%), indicating that the net surface irradiance increases when CALIOP- and CPR-derived cloud properties are used. Increasing the surface downward longwave irradiance is caused by larger cloud fractions (the global annual mean by 0.11, 0.04 excluding clouds with optical thickness less than 0.3) and lower cloud base heights (the global annual mean by 1.6 km). The increase of the surface downward longwave irradiance in the Arctic exceeds 10 W m-2 (˜4%) in winter because CALIOP and CPR detect more clouds in comparison with the cloud detection by the CERES cloud algorithm during polar night. The global annual mean surface downward longwave irradiance of

  12. Retrieval of the aerosol optical thickness from UV global irradiance measurements

    NASA Astrophysics Data System (ADS)

    Costa, M. J.; Salgueiro, V.; Bortoli, D.; Obregón, M. A.; Antón, M.; Silva, A. M.

    2015-12-01

    The UV irradiance is measured at Évora since several years, where a CIMEL sunphotometer integrated in AERONET is also installed. In the present work, measurements of UVA (315 - 400 nm) irradiances taken with Kipp&Zonen radiometers, as well as satellite data of ozone total column values, are used in combination with radiative transfer calculations, to estimate the aerosol optical thickness (AOT) in the UV. The retrieved UV AOT in Évora is compared with AERONET AOT (at 340 and 380 nm) and a fairly good agreement is found with a root mean square error of 0.05 (normalized root mean square error of 8.3%) and a mean absolute error of 0.04 (mean percentage error of 2.9%). The methodology is then used to estimate the UV AOT in Sines, an industrialized site on the Atlantic western coast, where the UV irradiance is monitored since 2013 but no aerosol information is available.

  13. Solar Irradiance from GOES Albedo performance in a Hydrologic Model Simulation of Snowmelt Runoff

    NASA Astrophysics Data System (ADS)

    Sumargo, E.; Cayan, D. R.; McGurk, B. J.

    2015-12-01

    In many hydrologic modeling applications, solar radiation has been parameterized using commonly available measures, such as the daily temperature range, due to scarce in situ solar radiation measurement network. However, these parameterized estimates often produce significant biases. Here we test hourly solar irradiance derived from the Geostationary Operational Environmental Satellite (GOES) visible albedo product, using several established algorithms. Focusing on the Sierra Nevada and White Mountain in California, we compared the GOES irradiance and that from a traditional temperature-based algorithm with incoming irradiance from pyranometers at 19 stations. The GOES based estimates yielded 21-27% reduction in root-mean-squared error (average over 19 sites). The derived irradiance is then prescribed as an input to Precipitation-Runoff Modeling System (PRMS). We constrain our experiment to the Tuolumne River watershed and focus our attention on the winter and spring of 1996-2014. A root-mean-squared error reduction of 2-6% in daily inflow to Hetch Hetchy at the lower end of the Tuolumne catchment was achieved by incorporating the insolation estimates at only 8 out of 280 Hydrologic Response Units (HRUs) within the basin. Our ongoing work endeavors to apply satellite-derived irradiance at each individual HRU.

  14. Implications of solar irradiance variability upon long-term changes in the Earth's atmospheric temperatures

    NASA Technical Reports Server (NTRS)

    Lee, Robert B., III

    1992-01-01

    From 1979 through 1987, it is believed that variability in the incoming solar energy played a significant role in changing the Earth's climate. Using high-precision spacecraft radiometric measurements, the incoming total solar irradiance (total amount of solar power per unit area) and the Earth's mean, global atmospheric temperatures were found to vary in phase with each other. The observed irradiance and temperature changes appeared to be correlated with the 11-year cycle of solar magnetic activity. During the period from 1979 through 1985, both the irradiance and temperature decreased. From 1985 to 1987, they increased. The irradiance changed approximately 0.1 percent, while the temperature varied as much as 0.6 C. During the 1979-1987 period, the temperatures were forecasted to rise linearly because of the anthropogenic build-up of carbon dioxide and the hypothesized 'global warming', 'greenhouse effect', scenarios. Contrary to these scenarios, the temperatures were found to vary in a periodic manner in phase with the solar irradiance changes. The observed correlations between irradiance and temperature variabilily suggest that the mean, global temperature of the Earth may decline between 1990 and 1997 as solar magnetic activity decreases.

  15. An introduction to quiet daily geomagnetic fields

    USGS Publications Warehouse

    Campbell, W.H.

    1989-01-01

    On days that are quiet with respect to solar-terrestrial activity phenomena, the geomagnetic field has variations, tens of gamma in size, with major spectral components at about 24, 12, 8, and 6 hr in period. These quiet daily field variations are primarily due to the dynamo currents flowing in the E region of the earth's ionosphere, are driven by the global thermotidal wind systems, and are dependent upon the local tensor conductivity and main geomagnetic field vector. The highlights of the behavior and interpretation of these quiet field changes, from their discovery in 1634 until the present, are discussed as an introduction to the special journal issue on Quiet Daily Geomagnetic Fields. ?? 1989 Birkha??user Verlag.

  16. Photometric measurements of solar irradiance variations due to sunspots

    NASA Technical Reports Server (NTRS)

    Chapman, G. A.; Herzog, A. D.; Laico, D. E.; Lawrence, J. K.; Templer, M. S.

    1989-01-01

    A photometric telescope constructed to obtain photometric sunspot areas and deficits on a daily basis is described. Data from this Cartesian full disk telescope (CFDT) are analyzed with attention given to the period between June 4 and June 17, 1985 because of the availability of overlapping sunspot area and irradiance deficit data from high-resolution digital spectroheliograms made with the San Fernando Observatory 28 cm vacuum solar telescope and spectroheliograph. The CFDT sunspot deficits suggest a substantial irradiance contribution from faculae and active region plage.

  17. Recent changes in solar irradiance and infrared irradiance related with air temperature and cloudiness at the King Sejong Station, Antarctica

    NASA Astrophysics Data System (ADS)

    Jung, Y.; Kim, J.; Cho, H.; Lee, B.

    2006-12-01

    The polar region play a critical role in the surface energy balance and the climate system of the Earth. The important question in the region is that what is the role of the Antarctic atmospheric heat sink of global climate. Thus, this study shows the trends of global solar irradiance, infrared irradiance, air temperature and cloudiness measured at the King Sejong station, Antarctica, during the period of 1996-2004 and determines their relationship and variability of the surface energy balance. Annual average of solar radiation and cloudiness is 81.8 Wm-2 and 6.8 oktas and their trends show the decrease of -0.24 Wm-2yr-1(-0.30 %yr-1) and 0.02 oktas yr-1(0.30 %yr-1). The change of solar irradiance is directly related to change of cloudiness and decrease of solar irradiance presents radiative cooling at the surface. Monthly mean infrared irradiance, air temperature and specific humidity shows the decrease of -2.11 Wm^{- 2}yr-1(-0.75 %yr-1), -0.07 'Cyr-1(-5.15 %yr-1) and -0.044 gkg-1yr-1(-1.42 %yr-1), respectively. Annual average of the infrared irradiance is 279.9 Wm-2 and correlated with the air temperature, specific humidity and cloudiness. A multiple regression model for estimation of the infrared irradiance using the components has been developed. Effects of the components on the infrared irradiance changes show 52 %, 19 % and 10 % for air temperature, specific humidity and cloudiness, respectively. Among the components, air temperature has a great influence on infrared irradiance. Despite the increase of cloudiness, the decrease in the infrared irradiance is due to the decrease of air temperature and specific humidity which have a cooling effect. Therefore, the net radiation of the surface energy balance shows radiative cooling of negative 11-24 Wm^{- 2} during winter and radiative warming of positive 32-83 Wm-2 during the summer. Thus, the amount of shortage and surplus at the surface is mostly balanced by turbulent flux of sensible and latent heat.

  18. Global upper ocean heat storage response to radiative forcing from changing solar irradiance and increasing greenhouse gas/aerosol concentrations

    NASA Astrophysics Data System (ADS)

    White, Warren B.; Cayan, Daniel R.; Lean, Judith

    1998-09-01

    We constructed gridded fields of diabatic heat storage changes in the upper ocean from 20°S to 60°N from historical temperature profiles collected from 1955 to 1996. We filtered these 42 year records for periods of 8 to 15 years and 15 to 30 years, producing depth-weighted vertical average temperature (DVT) changes from the sea surface to the top of the main pycnocline. Basin and global averages of these DVT changes reveal decadal and interdecadal variability in phase across the Indian, Pacific, Atlantic, and Global Oceans, each significantly correlated with changing surface solar radiative forcing at a lag of 0+/-2 years. Decadal and interdecadal changes in global average DVT are 0.06°+/-0.01°K and 0.04°K+/-0.01°K, respectively, the same as those expected from consideration of the Stefan-Boltzmann radiation balance (i.e., 0.3°K per Wm-2) in response to 0.1% changes in surface solar radiative forcing of 0.2 Wm-2 and 0.15 Wm-2, respectively. Global spatial patterns of DVT changes are similar to temperature changes simulated in coupled ocean-atmosphere models, suggesting that natural modes of Earth's variability are phase-locked to the solar irradiance cycle. A trend in global average DVT of 0.15°K over this 42 year record cannot be explained by changing surface solar radiative forcing. But when we consider the 0.5 Wm-2 increase in surface radiative forcing estimated from the increase in atmospheric greenhouse gas and aerosol (GGA) concentrations over this period [Intergovernmental Panel on Climate Change, 1995], the Stefan-Boltzmann radiation balance yields this observed change. Moreover, the sum of solar and GGA surface radiative forcing can explain the relatively sharp increase in global and basin average DVT in the late 1970's.

  19. A reconstruction of solar irradiance using a flux transport model

    NASA Astrophysics Data System (ADS)

    Dasi Espuig, Maria; Jiang, Jie; Krivova, Natalie; Solanki, Sami

    2013-04-01

    Reconstructions of solar irradiance into the past are of considerable interest for studies of solar influence on climate. Models based on the assumption that irradiance changes are caused by the evolution of the photospheric magnetic field have been the most successful in reproducing the measured irradiance variations. Our SATIRE-S model is one of these. It uses solar full-disc magnetograms as an input, and these are available for less than four decades. Thus, to reconstruct the irradiance back to times when no observed magnetograms are available, we combine the SATIRE-S model with synthetic magnetograms, produced using a surface flux transport model. The model is fed with daily, observed or modelled statistically, records of sunspot positions, areas, and tilt angles. To describe the secular change in the irradiance, we used the concept of overlapping ephemeral region cycles. With this technique TSI can be reconstructed back to 1610.

  20. A Bayesian modelling method for post-processing daily sub-seasonal to seasonal rainfall forecasts from global climate models and evaluation for 12 Australian catchments

    NASA Astrophysics Data System (ADS)

    Schepen, Andrew; Zhao, Tongtiegang; Wang, Quan J.; Robertson, David E.

    2018-03-01

    Rainfall forecasts are an integral part of hydrological forecasting systems at sub-seasonal to seasonal timescales. In seasonal forecasting, global climate models (GCMs) are now the go-to source for rainfall forecasts. For hydrological applications however, GCM forecasts are often biased and unreliable in uncertainty spread, and calibration is therefore required before use. There are sophisticated statistical techniques for calibrating monthly and seasonal aggregations of the forecasts. However, calibration of seasonal forecasts at the daily time step typically uses very simple statistical methods or climate analogue methods. These methods generally lack the sophistication to achieve unbiased, reliable and coherent forecasts of daily amounts and seasonal accumulated totals. In this study, we propose and evaluate a Rainfall Post-Processing method for Seasonal forecasts (RPP-S), which is based on the Bayesian joint probability modelling approach for calibrating daily forecasts and the Schaake Shuffle for connecting the daily ensemble members of different lead times. We apply the method to post-process ACCESS-S forecasts for 12 perennial and ephemeral catchments across Australia and for 12 initialisation dates. RPP-S significantly reduces bias in raw forecasts and improves both skill and reliability. RPP-S forecasts are also more skilful and reliable than forecasts derived from ACCESS-S forecasts that have been post-processed using quantile mapping, especially for monthly and seasonal accumulations. Several opportunities to improve the robustness and skill of RPP-S are identified. The new RPP-S post-processed forecasts will be used in ensemble sub-seasonal to seasonal streamflow applications.

  1. The Impact of Maternal, Child, and Family Characteristics on the Daily Well-Being and Parenting Experiences of Mothers of Children with Autism Spectrum Disorder

    ERIC Educational Resources Information Center

    Pruitt, Megan M.; Willis, Kelcie; Timmons, Lisa; Ekas, Naomi V.

    2016-01-01

    This study utilized a daily diaries method to explore the global factors that impact daily general affect and daily parenting interactions of mothers of children with autism spectrum disorder. Eighty-three mothers of a child with autism spectrum disorder between the ages of 3 and 13 years completed global assessments of maternal depressive…

  2. A new method for estimating the turbulent heat flux at the bottom of the daily mixed layer

    NASA Technical Reports Server (NTRS)

    Imawaki, Shiro; Niiler, Pearn P.; Gautier, Catherine H.; Knox, Robert A.; Halpern, David

    1988-01-01

    Temperature data in the mixed layer and net solar irradiance data at the sea surface are used to estimate the vertical turbulent heat flux at the bottom of the daily mixed layer. The method is applied to data obtained in the eastern tropical Pacific, where the daily cycle in the temperature field is confined to the upper 10-25 m. Equatorial turbulence measurements indicate that the turbulent heat flux is much greater during nighttime than daytime.

  3. Daily allergic multimorbidity in rhinitis using mobile technology: A novel concept of the MASK study.

    PubMed

    Bousquet, J; Devillier, P; Anto, J M; Bewick, M; Haahtela, T; Arnavielhe, S; Bedbrook, A; Murray, R; van Eerd, M; Fonseca, J A; Morais Almeida, M; Todo Bom, A; Menditto, E; Passalacqua, G; Stellato, C; Triggiani, M; Ventura, M T; Vezzani, G; Annesi-Maesano, I; Bourret, R; Bosse, I; Caimmi, D; Cartier, C; Demoly, P; Just, J; Portejoie, F; Siroux, V; Viart, F; Bergmann, K C; Keil, T; Klimek, L; Mösges, R; Pfaar, O; Shamai, S; Zuberbier, T; Mullol, J; Valero, A; Spranger, O; Tomazic, P V; Kowalski, M L; Kuna, P; Kupczyk, M; Raciborski, F; Samolinski, B; Toppila-Salmi, S K; Valovirta, E; Cruz, A A; Sarquis-Serpa, F; da Silva, J; Stelmach, R; Larenas-Linnemann, D; Rodriguez Gonzalez, M; Burguete Cabañas, M T; Kvedariene, V; Valiulis, A; Chavannes, N H; Fokkens, W J; Ryan, D; Sheikh, A; Bachert, C; Hellings, P W; VandenPlas, O; Ballardini, N; Kull, I; Melén, E; Westman, M; Wickman, M; Bindslev-Jensen, C; Eller, E; Bosnic-Anticevich, S; O'Hehir, R E; Agache, I; Bieber, T; Casale, T; Gemicioğlu, B; Ivancevich, J C; De Vries, G; Sorensen, M; Yorgancioglu, A; Laune, D

    2018-03-22

    Multimorbidity in allergic airway diseases is well known, but no data exist about the daily dynamics of symptoms and their impact on work. To better understand this, we aimed to assess the presence and control of daily allergic multimorbidity (asthma, conjunctivitis, rhinitis) and its impact on work productivity using a mobile technology, the Allergy Diary. We undertook a 1-year prospective observational study in which 4 210 users and 32 585 days were monitored in 19 countries. Five visual analogue scales (VAS) assessed the daily burden of the disease (i.e., global evaluation, nose, eyes, asthma and work). Visual analogue scale levels <20/100 were categorized as "Low" burden and VAS levels ≥50/100 as "High" burden. Visual analogue scales global measured levels assessing the global control of the allergic disease were significantly associated with allergic multimorbidity. Eight hypothesis-driven patterns were defined based on "Low" and "High" VAS levels. There were <0.2% days of Rhinitis Low and Asthma High or Conjunctivitis High patterns. There were 5.9% days with a Rhinitis High-Asthma Low pattern. There were 1.7% days with a Rhinitis High-Asthma High-Conjunctivitis Low pattern. A novel Rhinitis High-Asthma High-Conjunctivitis High pattern was identified in 2.9% days and had the greatest impact on uncontrolled VAS global measured and impaired work productivity. Work productivity was significantly correlated with VAS global measured levels. In a novel approach examining daily symptoms with mobile technology, we found considerable intra-individual variability of allergic multimorbidity including a previously unrecognized extreme pattern of uncontrolled multimorbidity. © 2018 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.

  4. Effect of clouds on UV and total irradiance at Paradise Bay, Antarctic Peninsula, from a summer 2000 campaign

    NASA Astrophysics Data System (ADS)

    Luccini, E.; Cede, A.; Piacentini, R. D.

    The analysis of ground-based measurements of solar erythemal ultraviolet (UV) irradiance with a Solar Light 501 biometer, and total (300-3000nm) irradiance with an Eppley B&W pyranometer at the Argentine Antarctic Base ``Almirante Brown'', Paradise Bay (64.9°S, 62.9°W, 10ma.s.l.) is presented. Measurement period extends from February 16 to March 28 2000. A relatively high mean albedo and a very clean atmosphere characterise the place. Sky conditions were of generally high cloud cover percentage. Clear-sky irradiance for each day was estimated with model calculations, and the effect of the cloudiness was studied through the ratio of measured to clear-sky value (r). Two particular cases were analysed: overcast sky without precipitation and overcast sky with rain or slight snowfall, the last one presenting frequently dense fog. Total irradiance was more attenuated than UV by the homogeneous cloudiness, obtaining mean r values of 0.54 for erythemal irradiance and 0.30 for total irradiance in the first case (without precipitation) and 0.27 and 0.17 respectively in the second case (with precipitation). Mean r values for the complete period were 0.58 for erythemal irradiance and 0.43 for total irradiance. Erythemal and total daily insolations reduce quickly at this epoch due to the increase of the noon solar zenith angle and the decrease of daylight time. Additionally, they were strongly modulated by cloudiness. Measured maxima were 2.71kJ/m2 and 18.42MJ/m2 respectively. Measurements were compared with satellite data. TOMS-inferred erythemal daily insolation shows the typical underestimation with respect to ground measurements at regions of high mean albedo. Measured mean total daily insolation agrees with climatological satellite data for the months of the campaign.

  5. A method for estimating direct normal solar irradiation from satellite data for a tropical environment

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Janjai, Serm

    In order to investigate a potential use of concentrating solar power technologies and select an optimum site for these technologies, it is necessary to obtain information on the geographical distribution of direct normal solar irradiation over an area of interest. In this work, we have developed a method for estimating direct normal irradiation from satellite data for a tropical environment. The method starts with the estimation of global irradiation on a horizontal surface from MTSAT-1R satellite data and other ground-based ancillary data. Then a satellite-based diffuse fraction model was developed and used to estimate the diffuse component of the satellite-derivedmore » global irradiation. Based on this estimated global and diffuse irradiation and the solar radiation incident angle, the direct normal irradiation was finally calculated. To evaluate its performance, the method was used to estimate the monthly average hourly direct normal irradiation at seven pyrheliometer stations in Thailand. It was found that values of monthly average hourly direct normal irradiation from the measurements and those estimated from the proposed method are in reasonable agreement, with a root mean square difference of 16% and a mean bias of -1.6%, with respect to mean measured values. After the validation, this method was used to estimate the monthly average hourly direct normal irradiation over Thailand by using MTSAT-1R satellite data for the period from June 2005 to December 2008. Results from the calculation were displayed as hourly and yearly irradiation maps. These maps reveal that the direct normal irradiation in Thailand was strongly affected by the tropical monsoons and local topography of the country. (author)« less

  6. Influence of daily versus monthly fire emissions on atmospheric model applications in the tropics

    NASA Astrophysics Data System (ADS)

    Marlier, M. E.; Voulgarakis, A.; Faluvegi, G.; Shindell, D. T.; DeFries, R. S.

    2012-12-01

    Fires are widely used throughout the tropics to create and maintain areas for agriculture, but are also significant contributors to atmospheric trace gas and aerosol concentrations. However, the timing and magnitude of fire activity can vary strongly by year and ecosystem type. For example, frequent, low intensity fires dominate in African savannas whereas Southeast Asian peatland forests are susceptible to huge pulses of emissions during regional El Niño droughts. Despite the potential implications for modeling interactions with atmospheric chemistry and transport, fire emissions have commonly been input into global models at a monthly resolution. Recognizing the uncertainty that this can introduce, several datasets have parsed fire emissions to daily and sub-daily scales with satellite active fire detections. In this study, we explore differences between utilizing the monthly and daily Global Fire Emissions Database version 3 (GFED3) products as inputs into the NASA GISS-E2 composition climate model. We aim to understand how the choice of the temporal resolution of fire emissions affects uncertainty with respect to several common applications of global models: atmospheric chemistry, air quality, and climate. Focusing our analysis on tropical ozone, carbon monoxide, and aerosols, we compare modeled concentrations with available ground and satellite observations. We find that increasing the temporal frequency of fire emissions from monthly to daily can improve correlations with observations, predominately in areas or during seasons more heavily affected by fires. Differences between the two datasets are more evident with public health applications: daily resolution fire emissions increases the number of days exceeding World Health Organization air quality targets.

  7. Variability of daily UV index in Jokioinen, Finland, in 1995-2015

    NASA Astrophysics Data System (ADS)

    Heikkilä, A.; Uusitalo, K.; Kärhä, P.; Vaskuri, A.; Lakkala, K.; Koskela, T.

    2017-02-01

    UV Index is a measure for UV radiation harmful for the human skin, developed and used to promote the sun awareness and protection of people. Monitoring programs conducted around the world have produced a number of long-term time series of UV irradiance. One of the longest time series of solar spectral UV irradiance in Europe has been obtained from the continuous measurements of Brewer #107 spectrophotometer in Jokioinen (lat. 60°44'N, lon. 23°30'E), Finland, over the years 1995-2015. We have used descriptive statistics and estimates of cumulative distribution functions, quantiles and probability density functions in the analysis of the time series of daily UV Index maxima. Seasonal differences in the estimated distributions and in the trends of the estimated quantiles are found.

  8. Measurements of global UV irradiance at Terranova Bay, Antactica, by a home made narrow band filter radiometer

    NASA Astrophysics Data System (ADS)

    Salvatore, Scaglione; di Sarcina, Ilaria; Flori, Daniele; Menchini, Francesca

    2010-05-01

    Filter radiometers measure the solar radiation in several channels (typically 4 to 7) with a bandwith from 2 to 10 nm. They require less maintenance than the spectroradiometer and they are able to work in hostile environment as for instance the polar regions. The spectral resolution depends on the width at half maximum (FWHM) of the filters and is generally lower than the spectroradiometer resolution (0.5 nm). Other than the robustness of this instruments, the main advantage of the filter radiometers is the high frequency with which all wavelengths can be measured, making this class of instrument well suited for investigating short term irradiance variation. In this work is presented the results of UV irradiance measurements performed by a very narrow band (FWHM less than 1 nm) filter radiometer at Antarctica Italia Base, Mario Zucchelli Station, Terranova Bay, lat. 74° 41.6084' south and lon. 164° 05.9224' est. All-dielectric Fabry-Perot filters were manufactured in the laboratories of the Optical Coating Group, ENEA, by the ion beam assistance physical vapor deposition technique. Nine filters select nine different wavelengths in the UV spectral range from 296.5 nm to 377 nm with about 1 minute of measurement period, i.e. each wavelength is measured about 1250 times per day. At the moment the radiometer are permanently located near MZS and the data are daily downloaded in ENEA, Rome, by a dedicated satellite channel. During the Antarctica winter the radiometer will be in standby mode, in this season MZS is closed, and it will be start to measure again in the Antarctica spring.

  9. In-vivo confirmation of the use of the dart thrower's motion during activities of daily living.

    PubMed

    Brigstocke, G H O; Hearnden, A; Holt, C; Whatling, G

    2014-05-01

    The dart thrower's motion is a wrist rotation along an oblique plane from radial extension to ulnar flexion. We report an in-vivo study to confirm the use of the dart thrower's motion during activities of daily living. Global wrist motion in ten volunteers was recorded using a three-dimensional optoelectronic motion capture system, in which digital infra-red cameras track the movement of retro-reflective marker clusters. Global wrist motion has been approximated to the dart thrower's motion when hammering a nail, throwing a ball, drinking from a glass, pouring from a jug and twisting the lid of a jar, but not when combing hair or manipulating buttons. The dart thrower's motion is the plane of global wrist motion used during most activities of daily living. Arthrodesis of the radiocarpal joint instead of the midcarpal joint will allow better wrist function during most activities of daily living by preserving the dart thrower's motion.

  10. Use of LiDAR for calculating solar irradiance on roofs and façades of buildings at city scale: Methodology, validation, and analysis

    NASA Astrophysics Data System (ADS)

    Cheng, Liang; Xu, Hao; Li, Shuyi; Chen, Yanming; Zhang, Fangli; Li, Manchun

    2018-04-01

    As the rate of urbanization continues to accelerate, the utilization of solar energy in buildings plays an increasingly important role in sustainable urban development. For this purpose, we propose a LiDAR-based joint approach for calculating the solar irradiance incident on roofs and façades of buildings at city scale, which includes a methodology for calculating solar irradiance, the validation of the proposed method, and analysis of its application. The calculation of surface irradiance on buildings may then inform photovoltaic power generation simulations, architectural design, and urban energy planning. Application analyses of the proposed method in the experiment area found that: (1) Global and direct irradiations vary significantly by hour, day, month and season, both following the same trends; however, diffuse irradiance essentially remains unchanged over time. (2) Roof irradiation, but not façade irradiation, displays distinct time-dependent patterns. (3) Global and direct irradiations on roofs are highly correlated with roof aspect and slope, with high global and direct irradiations observed on roofs of aspect 100-250° and slopes of 0-60°, whereas diffuse irradiation on roofs is only affected by roof slope. (4) The façade of a building receives higher levels of global and direct irradiations if facing southeast, south, and southwest; however, diffuse irradiation remains constant regardless of façade orientation.

  11. College students' daily-level reasons for not drinking.

    PubMed

    O'Hara, Ross E; Armeli, Stephen; Tennen, Howard

    2014-07-01

    Motivational models of alcohol use posit opposing approach and avoidance motives related to drinking, yet no micro-longitudinal study of college students has examined avoidance motives [i.e. reasons for not drinking (RND)]. This exploratory study examined daily- and person-level correlates of students' RNDs to identify factors that may inhibit alcohol use. College students (n = 1631; 54% female) participated in a 30-day daily diary study in which they reported RNDs for non-drinking evenings, as well as daily moods, global drinking motives and alcohol expectancies. Daily sadness was positively associated with not drinking due to having nobody with whom to drink but negatively associated with not drinking due to school work. Daily anxiety was negatively associated with not drinking due to lack of desire and positively associated with not drinking due to habit or having school or job responsibilities. At the person level, multiple RNDs were associated with both coping and conformity motives (but not social or enhancement motives), as well as positive (but not negative) alcohol expectancies. Results demonstrate the complexity of modelling mood-drinking contingencies proposed by motivational theories of alcohol use. Distinct moods may promote or inhibit drinking through various pathways, which could help explain the weak associations between daily mood and drinking level observed in previous studies. Measuring reasons both for and against drinking in micro-longitudinal studies (e.g. daily diaries) is recommended to better understand the processes underlying alcohol use and to inform future prevention efforts. © 2014 Australasian Professional Society on Alcohol and other Drugs.

  12. Global canopy interception from satellite observations

    USDA-ARS?s Scientific Manuscript database

    A new methodology for retrieving rainfall interception rates from multi satellite observations is presented. The approach makes use of the daily productof the Global Precipitation Climatology Project (GPCP) as driving data and applies Gash’s analytical model to derive interception rates at global sc...

  13. Solar UV-B irradiance and total ozone in Italy: Fluctuations and trends

    NASA Astrophysics Data System (ADS)

    Casale, G. R.; Meloni, D.; Miano, S.; Palmieri, S.; Siani, A. M.; Cappellani, F.

    2000-02-01

    Solar UV irradiance spectra (290-325 nm) together with daily total ozone column observations have been collected since 1992 by means of Brewer spectrophotometers at two Italian stations (Rome and Ispra). The available Brewer irradiance data, recorded around noon and at fixed solar zenith angles, together with the output of a radiative transfer model (the STAR model) are presented and analyzed. The Brewer irradiance measurements and total ozone fluctuations and anomalies are investigated, pointing out the correlation between the high-frequency O3 components and irradiance at 305 nm. In addition, the total ozone long time series of Arosa (170 km apart from Ispra) and Vigna di Valle (very close to Rome) are analyzed to illustrate evidence of temporal variations and a possible trend.

  14. The effect of surface irradiance on the absorption spectrum of chromophoric dissolved organic matter in the global ocean

    NASA Astrophysics Data System (ADS)

    Swan, Chantal M.; Nelson, Norman B.; Siegel, David A.; Kostadinov, Tihomir S.

    2012-05-01

    The cycling pathways of chromophoric dissolved organic matter (CDOM) within marine systems must be constrained to better assess the impact of CDOM on surface ocean photochemistry and remote sensing of ocean color. Photobleaching, the loss of absorption by CDOM due to light exposure, is the primary sink for marine CDOM. Herein the susceptibility of CDOM to photobleaching by sea surface-level solar radiation was examined in 15 samples collected from wide-ranging open ocean regimes. Samples from the Pacific, Atlantic, Indian and Southern Oceans were irradiated over several days with full-spectrum light under a solar simulator at in situ temperature in order to measure photobleaching rate and derive an empirical matrix, ɛsurf (m-1 μEin-1), which quantifies the effect of surface irradiance on the spectral absorption of CDOM. Irradiation responses among the ocean samples were similar within the ultraviolet (UV) region of the spectrum spanning 300-360 nm, generally exhibiting a decrease in the CDOM absorption coefficient (m-1) and concomitant increase in the CDOM spectral slope parameter, S (nm-1). However, an unexpected irradiation-induced increase in CDOM absorption between approximately 360 and 500 nm was observed for samples from high-nutrient low-chlorophyll (HNLC) environments. This finding was linked to the presence of dissolved nitrate and may explain discrepancies in action spectra for dimethylsulfide (DMS) photobleaching observed between the Equatorial Pacific and Subtropical North Atlantic Oceans. The nitrate-to-phosphate ratio explained 27-70% of observed variability in ɛsurf at observation wavelengths of 330-440 nm, while the initial spectral slope of the samples explained up to 52% of variability in ɛsurf at observation wavelengths of 310-330 nm. These results suggest that the biogeochemical and solar exposure history of the water column, each of which influence the chemical character and thus the spectral quality of CDOM and its photoreactivity, are the

  15. New global fire emission estimates and evaluation of volatile organic compounds

    Treesearch

    C. Wiedinmyer; L. K. Emmons; S. K. Akagi; R. J. Yokelson; J. J. Orlando; J. A. Al-Saadi; A. J. Soja

    2010-01-01

    A daily, high-resolution, global fire emissions model has been built to estimate emissions from open burning for air quality modeling applications: The Fire INventory from NCAR (FINN version 1). The model framework uses daily fire detections from the MODIS instruments and updated emission factors, specifically for speciated non-methane organic compounds (NMOC). Global...

  16. Estimation of the daily global solar radiation based on the Gaussian process regression methodology in the Saharan climate

    NASA Astrophysics Data System (ADS)

    Guermoui, Mawloud; Gairaa, Kacem; Rabehi, Abdelaziz; Djafer, Djelloul; Benkaciali, Said

    2018-06-01

    Accurate estimation of solar radiation is the major concern in renewable energy applications. Over the past few years, a lot of machine learning paradigms have been proposed in order to improve the estimation performances, mostly based on artificial neural networks, fuzzy logic, support vector machine and adaptive neuro-fuzzy inference system. The aim of this work is the prediction of the daily global solar radiation, received on a horizontal surface through the Gaussian process regression (GPR) methodology. A case study of Ghardaïa region (Algeria) has been used in order to validate the above methodology. In fact, several combinations have been tested; it was found that, GPR-model based on sunshine duration, minimum air temperature and relative humidity gives the best results in term of mean absolute bias error (MBE), root mean square error (RMSE), relative mean square error (rRMSE), and correlation coefficient ( r) . The obtained values of these indicators are 0.67 MJ/m2, 1.15 MJ/m2, 5.2%, and 98.42%, respectively.

  17. Globalization and the Experiences of Aging

    ERIC Educational Resources Information Center

    Fry, Christine L.

    2005-01-01

    Globalization is a product of urbanization and economic intensification which has escalated since the 1970s. Globalized markets have created many of the features of modern life including consumerism, increased cultural homogeneity, increased social polarization, erosion of the sovereignty of nation states, and delocalization of daily life. The…

  18. THE INFLUENCE OF ANTITUBERCULOUS VACCINATION ON THE COURSE OF THE TUBERCULOUS PROCESS IN CHRONIC IRRADIATION (in Russian)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Khudushina, T.A.

    1961-10-01

    Preliminary antituberculosis vaccination of tuberculosisinfected rabbits subjected to protracted x irradiation (10 r daily) yields a positive effect only during the first stages of irradiation. Disturbance of specific antituberculous immunity occurs in the process of development of chronic radiation sickness. At this period the tuberculous process acquires a marked exudative-necrotic character. (auth)

  19. Computing diffuse fraction of global horizontal solar radiation: A model comparison.

    PubMed

    Dervishi, Sokol; Mahdavi, Ardeshir

    2012-06-01

    For simulation-based prediction of buildings' energy use or expected gains from building-integrated solar energy systems, information on both direct and diffuse component of solar radiation is necessary. Available measured data are, however, typically restricted to global horizontal irradiance. There have been thus many efforts in the past to develop algorithms for the derivation of the diffuse fraction of solar irradiance. In this context, the present paper compares eight models for estimating diffuse fraction of irradiance based on a database of measured irradiance from Vienna, Austria. These models generally involve mathematical formulations with multiple coefficients whose values are typically valid for a specific location. Subsequent to a first comparison of these eight models, three better performing models were selected for a more detailed analysis. Thereby, the coefficients of the models were modified to account for Vienna data. The results suggest that some models can provide relatively reliable estimations of the diffuse fractions of the global irradiance. The calibration procedure could only slightly improve the models' performance.

  20. ARIMA representation for daily solar irradiance and surface air temperature time series

    NASA Astrophysics Data System (ADS)

    Kärner, Olavi

    2009-06-01

    Autoregressive integrated moving average (ARIMA) models are used to compare long-range temporal variability of the total solar irradiance (TSI) at the top of the atmosphere (TOA) and surface air temperature series. The comparison shows that one and the same type of the model is applicable to represent the TSI and air temperature series. In terms of the model type surface air temperature imitates closely that for the TSI. This may mean that currently no other forcing to the climate system is capable to change the random walk type variability established by the varying activity of the rotating Sun. The result should inspire more detailed examination of the dependence of various climate series on short-range fluctuations of TSI.

  1. Reconstruction of solar UV irradiance since 1974

    NASA Astrophysics Data System (ADS)

    Krivova, N. A.; Solanki, S. K.; Wenzler, T.; Podlipnik, B.

    2009-09-01

    Variations of the solar UV irradiance are an important driver of chemical and physical processes in the Earth's upper atmosphere and may also influence global climate. Here we reconstruct solar UV irradiance in the range 115-400 nm over the period 1974-2007 by making use of the recently developed empirical extension of the Spectral And Total Irradiance Reconstruction (SATIRE) models employing Solar Ultraviolet Spectral Irradiance Monitor (SUSIM) data. The evolution of the solar photospheric magnetic flux, which is a central input to the model, is described by the magnetograms and continuum images recorded at the Kitt Peak National Solar Observatory between 1974 and 2003 and by the Michelson Doppler Imager instrument on SOHO since 1996. The reconstruction extends the available observational record by 1.5 solar cycles. The reconstructed Ly-α irradiance agrees well with the composite time series by Woods et al. (2000). The amplitude of the irradiance variations grows with decreasing wavelength and in the wavelength regions of special interest for studies of the Earth's climate (Ly-α and oxygen absorption continuum and bands between 130 and 350 nm) is 1-2 orders of magnitude stronger than in the visible or if integrated over all wavelengths (total solar irradiance).

  2. Indoor and Outdoor Spectroradiometer Intercomparison for Spectral Irradiance Measurement

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Habte, A.; Andreas, A.; Ottoson, L.

    2014-05-01

    This report details the global spectral irradiance intercomparison using spectroradiometers that was organized by the National Renewable Energy Laboratory's Solar Radiation Research Laboratory. The intercomparison was performed both indoors and outdoors on September 17, 2013. Five laboratories participated in the intercomparison using 10 spectroradiometers, and a coordinated measurement setup and a common platform were employed to compare spectral irradiances under both indoor and outdoor conditions. The intercomparison aimed to understand the performance of the different spectroradiometers and to share knowledge in making spectral irradiance measurements. This intercomparison was the first of its kind in the United States.

  3. An Improved Approach for Estimating Daily Net Radiation over the Heihe River Basin

    PubMed Central

    Wu, Bingfang; Liu, Shufu; Zhu, Weiwei; Yan, Nana; Xing, Qiang; Tan, Shen

    2017-01-01

    Net radiation plays an essential role in determining the thermal conditions of the Earth’s surface and is an important parameter for the study of land-surface processes and global climate change. In this paper, an improved satellite-based approach to estimate the daily net radiation is presented, in which sunshine duration were derived from the geostationary meteorological satellite (FY-2D) cloud classification product, the monthly empirical as and bs Angstrom coefficients for net shortwave radiation were calibrated by spatial fitting of the ground data from 1997 to 2006, and the daily net longwave radiation was calibrated with ground data from 2007 to 2010 over the Heihe River Basin in China. The estimated daily net radiation values were validated against ground data for 12 months in 2008 at four stations with different underlying surface types. The average coefficient of determination (R2) was 0.8489, and the averaged Nash-Sutcliffe equation (NSE) was 0.8356. The close agreement between the estimated daily net radiation and observations indicates that the proposed method is promising, especially given the comparison between the spatial distribution and the interpolation of sunshine duration. Potential applications include climate research, energy balance studies and the estimation of global evapotranspiration. PMID:28054976

  4. An Improved Approach for Estimating Daily Net Radiation over the Heihe River Basin.

    PubMed

    Wu, Bingfang; Liu, Shufu; Zhu, Weiwei; Yan, Nana; Xing, Qiang; Tan, Shen

    2017-01-04

    Net radiation plays an essential role in determining the thermal conditions of the Earth's surface and is an important parameter for the study of land-surface processes and global climate change. In this paper, an improved satellite-based approach to estimate the daily net radiation is presented, in which sunshine duration were derived from the geostationary meteorological satellite (FY-2D) cloud classification product, the monthly empirical a s and b s Angstrom coefficients for net shortwave radiation were calibrated by spatial fitting of the ground data from 1997 to 2006, and the daily net longwave radiation was calibrated with ground data from 2007 to 2010 over the Heihe River Basin in China. The estimated daily net radiation values were validated against ground data for 12 months in 2008 at four stations with different underlying surface types. The average coefficient of determination ( R ²) was 0.8489, and the averaged Nash-Sutcliffe equation ( NSE ) was 0.8356. The close agreement between the estimated daily net radiation and observations indicates that the proposed method is promising, especially given the comparison between the spatial distribution and the interpolation of sunshine duration. Potential applications include climate research, energy balance studies and the estimation of global evapotranspiration.

  5. Analysis of Global Horizontal Irradiance in Version 3 of the National Solar Radiation Database.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hansen, Clifford; Martin, Curtis E.; Guay, Nathan Gene

    We report an analysis that compares global horizontal irradiance (GHI) estimates from version 3 of the National Solar Radiation Database (NSRDB v3) with surface measurements of GHI at a wide variety of locations over the period spanning from 2005 to 2012. The NSRDB v3 estimate of GHI are derived from the Physical Solar Model (PSM) which employs physics-based models to estimate GHI from measurements of reflected visible and infrared irradiance collected by Geostationary Operational Environment Satellites (GOES) and several other data sources. Because the ground measurements themselves are uncertain our analysis does not establish the absolute accuracy for PSM GHI.more » However by examining the comparison for trends and for consistency across a large number of sites, we may establish a level of confidence in PSM GHI and identify conditions which indicate opportunities to improve PSM. We focus our evaluation on annual and monthly insolation because these quantities directly relate to prediction of energy production from solar power systems. We find that generally, PSM GHI exhibits a bias towards overestimating insolation, on the order of 5% when all sky conditions are considered, and somewhat less (-3%) when only clear sky conditions are considered. The biases persist across multiple years and are evident at many locations. In our opinion the bias originates with PSM and we view as less credible that the bias stems from calibration drift or soiling of ground instruments. We observe that PSM GHI may significantly underestimate monthly insolation in locations subject to broad snow cover. We found examples of days where PSM GHI apparently misidentified snow cover as clouds, resulting in significant underestimates of GHI during these days and hence leading to substantial understatement of monthly insolation. Analysis of PSM GHI in adjacent pixels shows that the level of agreement between PSM GHI and ground data can vary substantially over distances on the order of 2 km

  6. Trends in Ocean Irradiance using a Radiative Model Forced with Terra Aerosols and Clouds

    NASA Technical Reports Server (NTRS)

    Gregg, Watson; Casey, Nancy; Romanou, Anastasia

    2010-01-01

    Aerosol and cloud information from MODIS on Terra provide enhanced capability to understand surface irradiance over the oceans and its variability. These relationships can be important for ocean biology and carbon cycles. An established radiative transfer model, the Ocean-Atmosphere Spectral Irradiance Model (OASIM) is used to describe ocean irradiance variability on seasonal to decadal time scales. The model is forced with information on aerosols and clouds from the MODIS sensor on Terra and Aqua. A 7-year record (2000-2006) showed no trends in global ocean surface irradiance or photosynthetic available irradiance (PAR). There were significant (P<0.05) negative trends in the Mediterranean Sea, tropical Pacific) and tropical Indian Oceans, of -7.0, -5.0 and -2.7 W/sq m respectively. Global interannual variability was also modest. Regional interannual variability was quite large in some ocean basins, where monthly excursions from climatology were often >20 W/sq m. The trends using MODIS data contrast with results from OASIM using liquid water path estimates from the International Satellite Cloud Climatology Project (ISCCP). Here, a global trend of -2 W/sq m was observed, largely dues to a large negative trend in the Antarctic -12 W/sq m. These results suggest the importance of the choice of liquid water path data sets in assessments of medium-length trends in ocean surface irradiance. The choices also impact the evaluation of changes in ocean biogeochemistry.

  7. Analysis of satellite-derived solar irradiance over the Netherlands

    NASA Astrophysics Data System (ADS)

    Dirksen, Marieke; Fokke Meirink, Jan; Sluiter, Raymond

    2017-04-01

    Measurements from geostationary satellites allow the retrieval of surface solar irradiance homogeneously over large areas, thereby providing essential information for the solar energy sector. In this paper, the SICCS solar irradiance data record derived from 12 years of Meteosat Second Generation satellite measurements is analysed with a focus on the Netherlands, where the spatial resolution is about 6 by 3 km2. Extensive validation of the SICCS data with pyranometer observations is performed, indicating a bias of approximately 3 W/m2 and RMSE of 11 W/m2 for daily data. Long term averages and seasonal variations of solar irradiance show regional patterns related to the surface type (e.g., coastal waters, forests, cities). The inter-annual variability over the time frame of the data record is quantified. Methods to merge satellite and surface observations into an optimized data record are explored.

  8. The Impact of Different Absolute Solar Irradiance Values on Current Climate Model Simulations

    NASA Technical Reports Server (NTRS)

    Rind, David H.; Lean, Judith L.; Jonas, Jeffrey

    2014-01-01

    Simulations of the preindustrial and doubled CO2 climates are made with the GISS Global Climate Middle Atmosphere Model 3 using two different estimates of the absolute solar irradiance value: a higher value measured by solar radiometers in the 1990s and a lower value measured recently by the Solar Radiation and Climate Experiment. Each of the model simulations is adjusted to achieve global energy balance; without this adjustment the difference in irradiance produces a global temperature change of 0.48C, comparable to the cooling estimated for the Maunder Minimum. The results indicate that by altering cloud cover the model properly compensates for the different absolute solar irradiance values on a global level when simulating both preindustrial and doubled CO2 climates. On a regional level, the preindustrial climate simulations and the patterns of change with doubled CO2 concentrations are again remarkably similar, but there are some differences. Using a higher absolute solar irradiance value and the requisite cloud cover affects the model's depictions of high-latitude surface air temperature, sea level pressure, and stratospheric ozone, as well as tropical precipitation. In the climate change experiments it leads to an underestimation of North Atlantic warming, reduced precipitation in the tropical western Pacific, and smaller total ozone growth at high northern latitudes. Although significant, these differences are typically modest compared with the magnitude of the regional changes expected for doubled greenhouse gas concentrations. Nevertheless, the model simulations demonstrate that achieving the highest possible fidelity when simulating regional climate change requires that climate models use as input the most accurate (lower) solar irradiance value.

  9. Measurement and modeling of solar irradiance components on horizontal and tilted planes

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Padovan, Andrea; Col, Davide del

    2010-12-15

    In this work new measurements of global and diffuse solar irradiance on the horizontal plane and global irradiance on planes tilted at 20 and 30 oriented due South and at 45 and 65 oriented due East are used to discuss the modeling of solar radiation. Irradiance data are collected in Padova (45.4 N, 11.9 E, 12 m above sea level), Italy. Some diffuse fraction correlations have been selected to model the hourly diffuse radiation on the horizontal plane. The comparison with the present experimental data shows that their prediction accuracy strongly depends on the sky characteristics. The hourly irradiance measurementsmore » taken on the tilted planes are compared with the estimations given by one isotropic and three anisotropic transposition models. The use of an anisotropic model, based on a physical description of the diffuse radiation, provides a much better accuracy, especially when measurements of the diffuse irradiance on the horizontal plane are not available and thus transposition models have to be applied in combination with a diffuse fraction correlation. This is particularly significant for the planes oriented away from South. (author)« less

  10. Radiation-Induced Epigenetic Alterations after Low and High LET Irradiations

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Aypar, Umut; Morgan, William F.; Baulch, Janet E.

    Epigenetics, including DNA methylation and microRNA (miRNA) expression, could be the missing link in understanding the delayed, non-targeted effects of radiation including radiationinduced genomic instability (RIGI). This study tests the hypothesis that irradiation induces epigenetic aberrations, which could eventually lead to RIGI, and that the epigenetic aberrations induced by low linear energy transfer (LET) irradiation are different than those induced by high LET irradiations. GM10115 cells were irradiated with low LET x-rays and high LET iron (Fe) ions and evaluated for DNA damage, cell survival and chromosomal instability. The cells were also evaluated for specific locus methylation of nuclear factor-kappamore » B (NFκB), tumor suppressor in lung cancer 1 (TSLC1) and cadherin 1 (CDH1) gene promoter regions, long interspersed nuclear element 1 (LINE-1) and Alu repeat element methylation, CpG and non-CpG global methylation and miRNA expression levels. Irradiated cells showed increased micronucleus induction and cell killing immediately following exposure, but were chromosomally stable at delayed times post-irradiation. At this same delayed time, alterations in repeat element and global DNA methylation and miRNA expression were observed. Analyses of DNA methylation predominantly showed hypomethylation, however hypermethylation was also observed. MiRNA shown to be altered in expression level after x-ray irradiation are involved in chromatin remodeling and DNA methylation. Different and higher incidence of epigenetic changes were observed after exposure to low LET x-rays than high LET Fe ions even though Fe ions elicited more chromosomal damage and cell killing. This study also shows that the irradiated cells acquire epigenetic changes even though they are chromosomally stable suggesting that epigenetic aberrations may arise in the cell without initiating RIGI.« less

  11. Global Lightning Response to Forbush Decreases in Short-term

    NASA Astrophysics Data System (ADS)

    Li, H.; Wu, Q.; Wang, C.

    2017-12-01

    During the past three decades, particular scientific attention has been drawn to the potential link between solar activities and global climate change. How the sun modulates the climate has always been controversial. There are three relatively widely accepted mechanisms illustrating this process: the total solar irradiance (TSI), the solar ultraviolet radiation (SUR), and the space weather mechanisms. As for space weather mechanism, the sun influences the microphysical process in cloud by modulating the cosmic ray flux and thus changes the cloud cover, which finally affects the earth's radiation balance. Unfortunately, the lack of related observations and some opposite research results make this mechanism rather debatable. In order to provide possible evidence for space weather mechanism, we study the influence of Forbush decreases (FDs) of galactic cosmic ray on global lightning activities, which to some extent represents the basic process of cosmic ray-atmospheric coupling. We use the daily lightning counts from 1998 to 2014 observed by LIS sensor aboard the TRMM satellite. Considering the "diurnal distribution" (occurring more in the afternoon than in the morning) and the "seasonal distribution" (occurring more in summer than in winter) of lightning activities as well as the 49-day precession of TRMM satellite, the daily lightning counts show an intricate periodic fluctuation. We propose a 3-step approach - latitude zone limitation, orbit branch selection and local time normalization - to eliminate it. As for FDs, we select them by checking the hourly neutron counts variation of each month of 17 years obtained from the Oulu Cosmic Ray Station. During the selection, we choose the FDs which are "strong" (decrease more than 6%) and "standard" (strongly decrease in a few hours to one day and gradually recover in about one week) to diminish the meteorological influence and other possible disturbance. For both case study and temporal superposition of several cases

  12. Response of Solar Irradiance to Sunspot-area Variations

    NASA Astrophysics Data System (ADS)

    Dudok de Wit, T.; Kopp, G.; Shapiro, A.; Witzke, V.; Kretzschmar, M.

    2018-02-01

    One of the important open questions in solar irradiance studies is whether long-term variability (i.e., on timescales of years and beyond) can be reconstructed by means of models that describe short-term variability (i.e., days) using solar proxies as inputs. Preminger & Walton showed that the relationship between spectral solar irradiance and proxies of magnetic-flux emergence, such as the daily sunspot area, can be described in the framework of linear system theory by means of the impulse response. We significantly refine that empirical model by removing spurious solar-rotational effects and by including an additional term that captures long-term variations. Our results show that long-term variability cannot be reconstructed from the short-term response of the spectral irradiance, which questions the extension of solar proxy models to these timescales. In addition, we find that the solar response is nonlinear in a way that cannot be corrected simply by applying a rescaling to a sunspot area.

  13. Modelling 1-minute directional observations of the global irradiance.

    NASA Astrophysics Data System (ADS)

    Thejll, Peter; Pagh Nielsen, Kristian; Andersen, Elsa; Furbo, Simon

    2016-04-01

    Direct and diffuse irradiances from the sky has been collected at 1-minute intervals for about a year from the experimental station at the Technical University of Denmark for the IEA project "Solar Resource Assessment and Forecasting". These data were gathered by pyrheliometers tracking the Sun, as well as with apertured pyranometers gathering 1/8th and 1/16th of the light from the sky in 45 degree azimuthal ranges pointed around the compass. The data are gathered in order to develop detailed models of the potentially available solar energy and its variations at high temporal resolution in order to gain a more detailed understanding of the solar resource. This is important for a better understanding of the sub-grid scale cloud variation that cannot be resolved with climate and weather models. It is also important for optimizing the operation of active solar energy systems such as photovoltaic plants and thermal solar collector arrays, and for passive solar energy and lighting to buildings. We present regression-based modelling of the observed data, and focus, here, on the statistical properties of the model fits. Using models based on the one hand on what is found in the literature and on physical expectations, and on the other hand on purely statistical models, we find solutions that can explain up to 90% of the variance in global radiation. The models leaning on physical insights include terms for the direct solar radiation, a term for the circum-solar radiation, a diffuse term and a term for the horizon brightening/darkening. The purely statistical model is found using data- and formula-validation approaches picking model expressions from a general catalogue of possible formulae. The method allows nesting of expressions, and the results found are dependent on and heavily constrained by the cross-validation carried out on statistically independent testing and training data-sets. Slightly better fits -- in terms of variance explained -- is found using the purely

  14. Inverse Analysis of Irradiated NuclearMaterial Gamma Spectra via Nonlinear Optimization

    NASA Astrophysics Data System (ADS)

    Dean, Garrett James

    Nuclear forensics is the collection of technical methods used to identify the provenance of nuclear material interdicted outside of regulatory control. Techniques employed in nuclear forensics include optical microscopy, gas chromatography, mass spectrometry, and alpha, beta, and gamma spectrometry. This dissertation focuses on the application of inverse analysis to gamma spectroscopy to estimate the history of pulse irradiated nuclear material. Previous work in this area has (1) utilized destructive analysis techniques to supplement the nondestructive gamma measurements, and (2) been applied to samples composed of spent nuclear fuel with long irradiation and cooling times. Previous analyses have employed local nonlinear solvers, simple empirical models of gamma spectral features, and simple detector models of gamma spectral features. The algorithm described in this dissertation uses a forward model of the irradiation and measurement process within a global nonlinear optimizer to estimate the unknown irradiation history of pulse irradiated nuclear material. The forward model includes a detector response function for photopeaks only. The algorithm uses a novel hybrid global and local search algorithm to quickly estimate the irradiation parameters, including neutron fluence, cooling time and original composition. Sequential, time correlated series of measurements are used to reduce the uncertainty in the estimated irradiation parameters. This algorithm allows for in situ measurements of interdicted irradiated material. The increase in analysis speed comes with a decrease in information that can be determined, but the sample fluence, cooling time, and composition can be determined within minutes of a measurement. Furthermore, pulse irradiated nuclear material has a characteristic feature that irradiation time and flux cannot be independently estimated. The algorithm has been tested against pulse irradiated samples of pure special nuclear material with cooling times of

  15. Estimates of tropical analysis differences in daily values produced by two operational centers

    NASA Technical Reports Server (NTRS)

    Kasahara, Akira; Mizzi, Arthur P.

    1992-01-01

    To assess the uncertainty of daily synoptic analyses for the atmospheric state, the intercomparison of three First GARP Global Experiment level IIIb datasets is performed. Daily values of divergence, vorticity, temperature, static stability, vertical motion, mixing ratio, and diagnosed diabatic heating rate are compared for the period of 26 January-11 February 1979. The spatial variance and mean, temporal mean and variance, 2D wavenumber power spectrum, anomaly correlation, and normalized square difference are employed for comparison.

  16. Solar spectral irradiance variability in cycle 24: observations and models

    NASA Astrophysics Data System (ADS)

    Marchenko, Sergey V.; DeLand, Matthew T.; Lean, Judith L.

    2016-12-01

    Utilizing the excellent stability of the Ozone Monitoring Instrument (OMI), we characterize both short-term (solar rotation) and long-term (solar cycle) changes of the solar spectral irradiance (SSI) between 265 and 500 nm during the ongoing cycle 24. We supplement the OMI data with concurrent observations from the Global Ozone Monitoring Experiment-2 (GOME-2) and Solar Radiation and Climate Experiment (SORCE) instruments and find fair-to-excellent, depending on wavelength, agreement among the observations, and predictions of the Naval Research Laboratory Solar Spectral Irradiance (NRLSSI2) and Spectral And Total Irradiance REconstruction for the Satellite era (SATIRE-S) models.

  17. Spatial estimation of sub-hour Global Horizontal Irradiance based on official observations and remote sensors.

    PubMed

    Gutierrez-Corea, Federico-Vladimir; Manso-Callejo, Miguel-Angel; Moreno-Regidor, María-Pilar; Velasco-Gómez, Jesús

    2014-04-11

    This study was motivated by the need to improve densification of Global Horizontal Irradiance (GHI) observations, increasing the number of surface weather stations that observe it, using sensors with a sub-hour periodicity and examining the methods of spatial GHI estimation (by interpolation) with that periodicity in other locations. The aim of the present research project is to analyze the goodness of 15-minute GHI spatial estimations for five methods in the territory of Spain (three geo-statistical interpolation methods, one deterministic method and the HelioSat2 method, which is based on satellite images). The research concludes that, when the work area has adequate station density, the best method for estimating GHI every 15 min is Regression Kriging interpolation using GHI estimated from satellite images as one of the input variables. On the contrary, when station density is low, the best method is estimating GHI directly from satellite images. A comparison between the GHI observed by volunteer stations and the estimation model applied concludes that 67% of the volunteer stations analyzed present values within the margin of error (average of ±2 standard deviations).

  18. Spatial Estimation of Sub-Hour Global Horizontal Irradiance Based on Official Observations and Remote Sensors

    PubMed Central

    Gutierrez-Corea, Federico-Vladimir; Manso-Callejo, Miguel-Angel; Moreno-Regidor, María-Pilar; Velasco-Gómez, Jesús

    2014-01-01

    This study was motivated by the need to improve densification of Global Horizontal Irradiance (GHI) observations, increasing the number of surface weather stations that observe it, using sensors with a sub-hour periodicity and examining the methods of spatial GHI estimation (by interpolation) with that periodicity in other locations. The aim of the present research project is to analyze the goodness of 15-minute GHI spatial estimations for five methods in the territory of Spain (three geo-statistical interpolation methods, one deterministic method and the HelioSat2 method, which is based on satellite images). The research concludes that, when the work area has adequate station density, the best method for estimating GHI every 15 min is Regression Kriging interpolation using GHI estimated from satellite images as one of the input variables. On the contrary, when station density is low, the best method is estimating GHI directly from satellite images. A comparison between the GHI observed by volunteer stations and the estimation model applied concludes that 67% of the volunteer stations analyzed present values within the margin of error (average of ±2 standard deviations). PMID:24732102

  19. Large uncertainties in observed daily precipitation extremes over land

    NASA Astrophysics Data System (ADS)

    Herold, Nicholas; Behrangi, Ali; Alexander, Lisa V.

    2017-01-01

    We explore uncertainties in observed daily precipitation extremes over the terrestrial tropics and subtropics (50°S-50°N) based on five commonly used products: the Climate Hazards Group InfraRed Precipitation with Stations (CHIRPS) dataset, the Global Precipitation Climatology Centre-Full Data Daily (GPCC-FDD) dataset, the Tropical Rainfall Measuring Mission (TRMM) multi-satellite research product (T3B42 v7), the Precipitation Estimation from Remotely Sensed Information using Artificial Neural Networks-Climate Data Record (PERSIANN-CDR), and the Global Precipitation Climatology Project's One-Degree Daily (GPCP-1DD) dataset. We use the precipitation indices R10mm and Rx1day, developed by the Expert Team on Climate Change Detection and Indices, to explore the behavior of "moderate" and "extreme" extremes, respectively. In order to assess the sensitivity of extreme precipitation to different grid sizes we perform our calculations on four common spatial resolutions (0.25° × 0.25°, 1° × 1°, 2.5° × 2.5°, and 3.75° × 2.5°). The impact of the chosen "order of operation" in calculating these indices is also determined. Our results show that moderate extremes are relatively insensitive to product and resolution choice, while extreme extremes can be very sensitive. For example, at 0.25° × 0.25° quasi-global mean Rx1day values vary from 37 mm in PERSIANN-CDR to 62 mm in T3B42. We find that the interproduct spread becomes prominent at resolutions of 1° × 1° and finer, thus establishing a minimum effective resolution at which observational products agree. Without improvements in interproduct spread, these exceedingly large observational uncertainties at high spatial resolution may limit the usefulness of model evaluations. As has been found previously, resolution sensitivity can be largely eliminated by applying an order of operation where indices are calculated prior to regridding. However, this approach is not appropriate when true area averages are desired

  20. Central nervous system transplantation benefited by low-level laser irradiation

    NASA Astrophysics Data System (ADS)

    Rochkind, S.; Lubart, Rachel; Wollman, Yoram; Simantov, Rabi; Nissan, Moshe; Barr-Nea, Lilian

    1990-06-01

    Effect of low-level laser irradiation on the central nervous system transplantation is reported. Ernbryonal brain allografts were transplanted into the brain of 20 adult rats and peripheral nerve graft transplanted into the severely injured spinal cord of 16 dogs. The operated wound of 10 rats and 8 dogs were exposed daily for 21 days to lowpower laser irradiation CW HeNe laser (35 mW, 632.8 run, energy density of 30 J/cm2 at each point for rats and 70 J/cm2 at each point for dogs). This study shows that (i) the low-level laser irradiation prevents extensive glial scar formation (a limiting factor in CNS regeneration) between embryonal transplants and host brain; (ii) Dogs made paraplegic by spinal cord injury were able to walk 3-6 months later. Recovery of these dogs was effected by the implantation of a fragment of autologous sciatic nerve at the site of injury and subsequently exposing the dogs to low-level laser irradiation. The effect of laser irradiation on the embryonal nerve cells grown in tissue culture was also observed. We found that low-level laser irradiation induced intensive migration of neurites outward of the aggregates 15-22 The results of the present study and our previous investigations suggest that low-level laser irradiation is a novel tool for treatment of peripheral and central nervous system injuries.

  1. The impact of maternal, child, and family characteristics on the daily well-being and parenting experiences of mothers of children with autism spectrum disorder.

    PubMed

    Pruitt, Megan M; Willis, Kelcie; Timmons, Lisa; Ekas, Naomi V

    2016-11-01

    This study utilized a daily diaries method to explore the global factors that impact daily general affect and daily parenting interactions of mothers of children with autism spectrum disorder. Eighty-three mothers of a child with autism spectrum disorder between the ages of 3 and 13 years completed global assessments of maternal depressive symptoms, child autism spectrum disorder symptom severity, and family functioning. Mothers then reported on their daily negative and positive affect as well as their daily positive and frustrating parenting interactions for 14 consecutive days. The results indicated that higher levels of maternal depressive symptoms were related to decreased daily positive affect, whereas greater child social motivation impairments were related to increased daily positive affect. Only maternal depressive symptoms were associated with increased daily negative affect. Furthermore, higher levels of family cohesion were related to increased daily positive parenting interactions. Finally, higher maternal depressive symptoms as well as family rigidity were related to increased daily frustrating parenting interactions. Implications for interventions focused on the family system are discussed. © The Author(s) 2016.

  2. Comparison of High-Frequency Solar Irradiance: Ground Measured vs. Satellite-Derived

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lave, Matthew; Weekley, Andrew

    2016-11-21

    High-frequency solar variability is an important to grid integration studies, but ground measurements are scarce. The high resolution irradiance algorithm (HRIA) has the ability to produce 4-sceond resolution global horizontal irradiance (GHI) samples, at locations across North America. However, the HRIA has not been extensively validated. In this work, we evaluate the HRIA against a database of 10 high-frequency ground-based measurements of irradiance. The evaluation focuses on variability-based metrics. This results in a greater understanding of the errors in the HRIA as well as suggestions for improvement to the HRIA.

  3. Intent to Quit among Daily and Non-Daily College Student Smokers

    ERIC Educational Resources Information Center

    Pinsker, E. A.; Berg, C. J.; Nehl, E. J.; Prokhorov, A. V.; Buchanan, T. S.; Ahluwalia, J. S.

    2013-01-01

    Given the high prevalence of young adult smoking, we examined (i) psychosocial factors and substance use among college students representing five smoking patterns and histories [non-smokers, quitters, native non-daily smokers (i.e. never daily smokers), converted non-daily smokers (i.e. former daily smokers) and daily smokers] and (ii) smoking…

  4. LISIRD: Where to go for Solar Irradiance Data

    NASA Astrophysics Data System (ADS)

    Wilson, A.; Pankratz, C. K.; Lindholm, D. M.; Snow, M.; Knapp, B.; Woodraska, D.; Templeman, B.; Woods, T.; Eparvier, F.; Fontenla, J.; Harder, J.; Bill, M.

    2008-12-01

    LASP, the Laboratory for Atmospheric and Space Physics, has been providing web access to solar irradiance measurements, reference spectra, composites and model data covering the solar spectrum from .1 to 2400 nm through LISIRD, the LASP Interactive Solar IRradiance Datacenter. No single instrument can measure the solar spectral irradiance from X-rays to the IR, but the ensemble of LASP instruments can. LISIRD uses a single interface to provide easy, logical access to a variety of mission data, merged in time and wavelength. Daily space weather measurements are available, including total solar irradiance (TSI), Lyman Alpha (121 nm), Magnesium II Index (280 nm), He II (30.4 nm), FE XVI (33.5 nm), and the FUV continuum (145 to 165 nm). More recently, LISIRD has recently added the Whole Heliosphere Interval (WHI) Solar Irradiance time series, which provides a quiet sun reference spectra for the period of April 10-16 of 2008. LISIRD also recently added a composite solar spectral irradiance product over the range of 120 to 400 nm for the time period from November 8, 1978 to August 1, 2005. This product, created by Mathew Deland at SSAI, merges data from six different satellites into a single SSI product. And, we are currently adding a time series for daily solar spectral irradiance from 1950 to 2006, created by Judith Lean of the Naval Research Lab. This product adjusts observed irradiance for a given wavelength with parameters that represent known sources of variability at that wavelength. LISIRD remains committed to improving data access in a variety of ways. We are planning and developing a means for the broader community of scientists to easily determine data availability for a particular date range without having to know mission or instrument details. Improved data subsetting will allow users to request only the time range or spectra that users need, making data management generally easier. We expect to continue to enhance our data offerings. Future vision for

  5. VIRGO: Experiment for helioseismology and solar irradiance monitoring

    NASA Technical Reports Server (NTRS)

    Froehlich, Claus; Andersen, Bo N.

    1995-01-01

    The scientific objectives of the variability of solar irradiance and gravity oscillations (VIRGO) experiment are as follows: to determine the characteristics of pressure and internal gravity oscillations by observing irradiance and radiance variations; to measure the solar total and spectral irradiance, and to quantify their variability. Helioseismological methods can be applied to these data in order to probe the solar interior. Certain convection characteristics and their interaction with magnetic fields will be studied from the results of the irradiance monitoring and from the comparison of the amplitudes and phases of the oscillations as observed from the brightness by VIRGO and from velocity by the global oscillations at low frequency (GOLF) experiment. The VIRGO experiment contains two active-cavity radiometers that monitor the solar constant, two three-channel sunphotometers that measure the spectral irradiance, and a low resolution imager with 12 pixels that measures the radiance distribution over the solar disk at 500 nm. The scientific objectives of VIRGO are presented, the instruments and the data acquisition and control system are described, and their measured performances are given.

  6. Monitoring global snow cover

    NASA Technical Reports Server (NTRS)

    Armstrong, Richard; Hardman, Molly

    1991-01-01

    A snow model that supports the daily, operational analysis of global snow depth and age has been developed. It provides improved spatial interpolation of surface reports by incorporating digital elevation data, and by the application of regionalized variables (kriging) through the use of a global snow depth climatology. Where surface observations are inadequate, the model applies satellite remote sensing. Techniques for extrapolation into data-void mountain areas and a procedure to compute snow melt are also contained in the model.

  7. Volumetric response of intracranial meningioma after photon or particle irradiation.

    PubMed

    Mozes, Petra; Dittmar, Jan Oliver; Habermehl, Daniel; Tonndorf-Martini, Eric; Hideghety, Katalin; Dittmar, Anne; Debus, Jürgen; Combs, Stephanie E

    2017-03-01

    Meningiomas are usually slow growing, well circumscribed intracranial tumors. In symptom-free cases observation with close follow-up imaging could be performed. Symptomatic meningiomas could be surgically removed and/or treated with radiotherapy. The study aimed to evaluate the volumetric response of intracranial meningiomas at different time points after photon, proton, and a mixed photon and carbon ion boost irradiation. In Group A 38 patients received proton therapy (median dose: 56 GyE in 1.8-2 GyE daily fractions) or a mixed photon/carbon ion therapy (50 Gy in 2 Gy daily fractions with intensity modulated radiotherapy (IMRT) and 18 GyE in 3 GyE daily dose carbon ion boost). Thirty-nine patients (Group B) were treated by photon therapy with IMRT or fractionated stereotactic radiotherapy technique (median dose: 56 Gy in 1.8-2 Gy daily fractions). The delineation of the tumor volume was based on the initial, one- and two-year follow-up magnetic resonance imaging and these volumes were compared to evaluate the volumetric tumor response. Significant tumor volume shrinkage was detected at one- and at two-year follow-up both after irradiation by particles and by photons. No significant difference in tumor volume change was observed between photon, proton or combined photon plus carbon ion boost treated patients. WHO grade and gender appear to be determining factors for tumor volume shrinkage. Significant volumetric shrinkage of meningiomas could be observed independently of the applied radiation modality. Long-term follow-up is recommended to evaluate further dynamic of size reduction and its correlation with outcome data.

  8. Longitudinal Investigation of Adaptive Functioning following Conformal Irradiation for Pediatric Craniopharyngioma and Low-Grade Glioma

    PubMed Central

    Netson, Kelli L.; Conklin, Heather M.; Wu, Shengjie; Xiong, Xiaoping; Merchant, Thomas E.

    2013-01-01

    Purpose Children treated for brain tumors with conformal radiation therapy experience preserved cognitive outcomes. Early evidence suggests that adaptive functions or independent living skills may be spared. This longitudinal investigation prospectively examined intellectual and adaptive functioning during the first 5 years following irradiation for childhood craniopharyngioma and low-grade glioma (LGG). The effect of visual impairment on adaptive outcomes was investigated. Methods and Materials Children with craniopharyngioma (n=62) and LGG (n=77) were treated using conformal or intensity-modulated radiation therapy. The median age was 8.05 years (3.21 years –17.64 years) and 8.09 years (2.20 years–19.27 years), respectively. Serial cognitive evaluations including measures of intelligence quotient (IQ) and the Vineland Adaptive Behavior Scales (VABS) were conducted at pre-irradiation baseline, 6 months after treatment, and annually through 5 years. A total of 588 evaluations were completed during the follow-up period. Results Baseline assessment revealed no deficits in IQ and VABS indices for children with craniopharyngioma, with significant (p < .05) longitudinal decline in VABS Communication and Socialization indices. Clinical factors associated with more rapid decline included females and pre-irradiation chemotherapy (interferon). The only change in VABS Daily Living Skills correlated with IQ change (r = .34; p = .01) in children with craniopharyngioma. Children with LGG performed below population norms (p < .05) at baseline on VABS Communication, Daily Living Indices, and the Adaptive Behavior Composite, with significant (p < .05) longitudinal decline limited to VABS Communication. Older age at irradiation was a protective factor against longitudinal decline. Severe visual impairment did not independently correlate with poorer adaptive outcomes for either tumor group. Conclusions There was relative sparing of post-irradiation functional outcomes over time

  9. The Thermal Regulation of Gravitational Instabilities in Protoplanetary Disks. IV. Simulations with Envelope Irradiation

    NASA Astrophysics Data System (ADS)

    Cai, Kai; Durisen, Richard H.; Boley, Aaron C.; Pickett, Megan K.; Mejía, Annie C.

    2008-02-01

    It is generally thought that protoplanetary disks embedded in envelopes are more massive and thus more susceptible to gravitational instabilities (GIs) than exposed disks. We present three-dimensional radiative hydrodynamic simulations of protoplanetary disks with the presence of envelope irradiation. For a disk with a radius of 40 AU and a mass of 0.07 M⊙ around a young star of 0.5 M⊙, envelope irradiation tends to weaken and even suppress GIs as the irradiating flux is increased. The global mass transport induced by GIs is dominated by lower order modes, and irradiation preferentially suppresses higher order modes. As a result, gravitational torques and mass inflow rates are actually increased by mild irradiation. None of the simulations produce dense clumps or rapid cooling by convection, arguing against direct formation of giant planets by disk instability, at least in irradiated disks. However, dense gas rings and radial mass concentrations are produced, and these might be conducive to accelerated planetary core formation. Preliminary results from a simulation of a massive embedded disk with physical characteristics similar to one of the disks in the embedded source L1551 IRS 5 indicate a long radiative cooling time and no fragmentation. The GIs in this disk are dominated by global two- and three-armed modes.

  10. Enhancement of the MODIS Daily Snow Albedo Product

    NASA Technical Reports Server (NTRS)

    Hall, Dorothy K.; Schaaf, Crystal B.; Wang, Zhuosen; Riggs, George A.

    2009-01-01

    The MODIS daily snow albedo product is a data layer in the MOD10A1 snow-cover product that includes snow-covered area and fractional snow cover as well as quality information and other metadata. It was developed to augment the MODIS BRDF/Albedo algorithm (MCD43) that provides 16-day maps of albedo globally at 500-m resolution. But many modelers require daily snow albedo, especially during the snowmelt season when the snow albedo is changing rapidly. Many models have an unrealistic snow albedo feedback in both estimated albedo and change in albedo over the seasonal cycle context, Rapid changes in snow cover extent or brightness challenge the MCD43 algorithm; over a 16-day period, MCD43 determines whether the majority of clear observations was snow-covered or snow-free then only calculates albedo for the majority condition. Thus changes in snow albedo and snow cover are not portrayed accurately during times of rapid change, therefore the current MCD43 product is not ideal for snow work. The MODIS daily snow albedo from the MOD10 product provides more frequent, though less robust maps for pixels defined as "snow" by the MODIS snow-cover algorithm. Though useful, the daily snow albedo product can be improved using a daily version of the MCD43 product as described in this paper. There are important limitations to the MOD10A1 daily snow albedo product, some of which can be mitigated. Utilizing the appropriate per-pixel Bidirectional Reflectance Distribution Functions (BRDFs) can be problematic, and correction for anisotropic scattering must be included. The BRDF describes how the reflectance varies with view and illumination geometry. Also, narrow-to-broadband conversion specific for snow on different surfaces must be calculated and this can be difficult. In consideration of these limitations of MOD10A1, we are planning to improve the daily snow albedo algorithm by coupling the periodic per-pixel snow albedo from MCD43, with daily surface ref|outanoom, In this paper, we

  11. Chronic and Daily Stressors Along With Negative Affect Interact to Predict Daily Tiredness.

    PubMed

    Hartsell, Elizabeth N; Neupert, Shevaun D

    2017-11-01

    The present study examines the within-person relationship of daily stressors and tiredness and whether this depends on daily negative affect and individual differences in chronic stress. One hundred sixteen older adult participants were recruited via Amazon's Mechanical Turk for a 9-day daily diary study. Daily tiredness, daily stressors, and negative affect were measured each day, and chronic stress was measured at baseline. Daily stressors, daily negative affect, and chronic stress interacted to predict daily tiredness. People with high chronic stress who experienced an increase in daily negative affect were the most reactive to daily stressors in terms of experiencing an increase in daily tiredness. We also found that people with low levels of chronic stress were the most reactive to daily stressors when they experienced low levels of daily negative affect. Our results highlight the need for individualized and contextualized approaches to combating daily tiredness in older adults.

  12. Dose-time relationships for post-irradiation cutaneous telangiectasia

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Cohen, L.; Ubaldi, S.E.

    1977-01-01

    Seventy-five patients who had received electron beam radiation a year or more previously were studied. The irradiated skin portals were photographed and late reactions graded in terms of the number and severity of telangiectatic lesions observed. The skin dose, number of fractions, overall treatment time and irradiated volume were recorded in each case. A Strandqvist-type iso-effect line was derived for this response. A multi-probit search program also was used to derive best-fitting cell population kinetic parameters for the same data. From these parameters a comprehensive iso-effect table could be computed for a wide range of treatment schedules including daily treatmentmore » as well as fractionation at shorter and longer intervals; this provided a useful set of normal tissue tolerance limits for late effects.« less

  13. ECPC’s weekly to seasonal global forecasts

    Treesearch

    John O. Roads; Shyh-Chin Chen; Francis M. Fujioka

    2001-01-01

    The Scripps Experimental Climate Prediction Center (ECPC) has been making experimental, near-real-time seasonal global forecasts since 26 September 1997 with the NCEP global spectral model used for the reanalysis. Images of these forecasts, at daily to seasonal timescales, are provided on the World Wide Web and digital forecast products are provided on the ECPC...

  14. Relationships between meaning in life, social and achievement events, and positive and negative affect in daily life.

    PubMed

    Machell, Kyla A; Kashdan, Todd B; Short, Jerome L; Nezlek, John B

    2015-06-01

    Research on meaning in life has generally focused on global meaning judgments. This study examined how people's daily experiences, represented by events that occur in daily life, influence their perceived sense of meaning on a daily basis. One hundred sixty-two college students completed daily reports for 2 weeks. We examined the relationships among daily social and achievement events, daily positive and negative affect, and daily meaning in life. In addition, we tested the possible moderating influence of depressive symptoms on these relationships. Positive daily social and achievement events were related to greater daily meaning, above and beyond the contributions of daily positive and negative affect. Negative social and achievement events were related to less daily meaning, and negative achievement events covaried with daily meaning above and beyond positive and negative affect. Depression moderated the relationships between positive events and meaning, such that people who reported more depressive symptoms had greater increases in daily meaning in response to positive social and achievement events than individuals who reported fewer symptoms. These findings suggest the important role that daily events may play in fluctuations in people's affective experiences and sense of meaning in life. © 2014 Wiley Periodicals, Inc.

  15. Estimations of the Global Distribution and Time Series of UV Noontime Irradiance (305, 310, 324, 380 nm, and Erythemal) from TOMS and SeaWiFS Data

    NASA Technical Reports Server (NTRS)

    Herman, J.

    2004-01-01

    The amount of UV irradiance reaching the Earth's surface is estimated from the measured cloud reflectivity, ozone, aerosol amounts, and surface reflectivity time series from 1980 to 1992 and 1997 to 2000 to estimate changes that have occurred over a 21-year period. Recent analysis of the TOMS data shows that there has been an apparent increase in reflectivity (decrease in W) in the Southern Hemisphere that is related to a calibration error in EP-TOMS. Data from the well-calibrated SeaWiFS satellite instrument have been used to correct the EP-TOMS reflectivity and UV time series. After correction, some of the local trend features seen in the N7 time series (1980 to 1992) have been continued in the combined time series, but the overall zonal average and global trends have changed. In addition to correcting the EP-TOMS radiance calibration, the use of SeaWiFS cloud data permits estimation of UV irradiance at higher spatial resolution (1 to 4 km) than is available from TOMS (100 km) under the assumption that ozone is slowly varying over a scale of 100 km. The key results include a continuing decrease in cloud cover over Europe and North America with a corresponding increase in UV and a decrease in UV irradiance near Antarctica.

  16. Intraindividual change and variability in daily stress processes: Findings from two measurement-burst diary studies

    PubMed Central

    Sliwinski, Martin J.; Almeida, David M.; Smyth, Joshua; Stawski, Robert S.

    2010-01-01

    There is little longitudinal information on aging-related changes in emotional responses to negative events. The present manuscript examined intraindividual change and variability in the within-person coupling of daily stress and negative affect (NA) using data from two-measurement burst daily diary studies. Three main findings emerged. First, average reactivity to daily stress increased longitudinally, and this increase was evident across most the adult lifespan. Second, individual differences in emotional reactivity to daily stress exhibited long-term temporal stability, but this stability was greatest in midlife and decreased in old age. And third, reactivity to daily stress varied reliably within-persons (across-time), with individual exhibiting higher levels of reactivity during times when reporting high levels of global subject stress in previous month. Taken together, the present results emphasize the importance of modeling dynamic psychosocial and aging processes that operate across different time scales for understanding age-related changes in daily stress processes. PMID:20025399

  17. Effect of gamma irradiation on the wear behavior of human tooth dentin.

    PubMed

    Qing, Ping; Huang, Shengbin; Gao, ShanShan; Qian, LinMao; Yu, HaiYang

    2016-12-01

    The objective of this study was to evaluate the effect of gamma irradiation on the wear behavior of human tooth dentin in terms of possible alterations in crystallinity, grain size, and composition. Human premolars (n = 19) were collected to obtain the perpendicular or parallel to the direction of the dentin tubule specimens. Each specimen was subjected to 60 Gy of gamma irradiation, in daily increments of 2 Gy. The nanoscratch tests were conducted. The scratch traces were observed via scanning electron microscope (SEM) and surface profilometer. X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR) were used to investigate the alteration of crystallography and chemical composition of dentin after irradiation. The change of surface microhardness (SMH) was also evaluated. The nanoscratch results showed that the friction coefficient of dentin after irradiation became higher, and the depths and widths of scratch were greater than that of dentin before irradiation. Additionally, irradiation decreased the crystallinity of dentin and induced the formation of bigger crystals. The carbonate/mineral ratio was increased. Furthermore, a significant reduction in microhardness after irradiation was observed. The main damage mechanisms consisted of the formation of delamination and crack in both the specimens cut perpendicular and parallel to tubule dentin after irradiation. Irradiation affected directly the wear behavior of tooth dentin, accompanied by the alterations in crystallography, chemical composition, and surface microhardness of dentin. This would help extend understanding the influence of irradiation on dentin and provide suggestions for selecting more suitable materials for irradiated tooth.

  18. Mastering Social and Organization Goals: Strategy Use by Two Children with Asperger Syndrome during Cognitive Orientation to Daily Occupational Performance

    ERIC Educational Resources Information Center

    Rodger, Sylvia; Vishram, Alysha

    2010-01-01

    Preliminary data supports the effectiveness of Cognitive Orientation to (daily) Occupational Performance (CO-OP) for children with Asperger syndrome (AS). Children with AS often experience social and organizational difficulties spanning daily occupations. This case study explored the pattern of Global Strategies and Domain-Specific Strategies…

  19. Impacts of ENSO on global hydrology

    NASA Astrophysics Data System (ADS)

    Ward, P. J.; Eisner, S.; Flörke, M.; Kummu, M.

    2012-04-01

    The economic consequences of flooding are huge, as exemplified by recent major floods in Thailand, Pakistan, and Australia. Moreover, research shows that economic losses due to flooding have increased dramatically in recent decades. Whilst much research is being carried out to assess how this may be related to socioeconomic development (increased exposure to floods) or climate change (increased hazard), the role of interannual climate variability is poorly understood at the global scale. We provide the first global assessment of the sensitivity of extreme global river discharge to the El Niño Southern Oscillation (ENSO). Past studies have either: (a) assessed this at the local scale; or (b) assessed only global correlations between ENSO and mean river discharge. Firstly, we used a daily observed discharge dataset for 622 gauging stations (from the GRDC database), and assessed and mapped correlations and sensitivities between these time-series and several indices of ENSO. We found that, on average, for the stations studied ENSO has a greater impact on annual high-flow events than on mean annual discharge, especially in the extra-tropics. However, the geographical coverage of the dataset is poor in some regions, and is highly skewed towards certain areas (e.g. North America, Europe, and eastern Australia). This renders a truly global assessment of ENSO impacts impossible based on these observed time-series. Hence, we are also using a modelling approach to estimate correlations and sensitivities in all basins, gauged and ungauged. For this, we are using a gridded time-series of modelled daily discharge from the EU-WATCH project, and analysing relationships between these time-series (per grid-cell) and indices of ENSO. This allows for the first truly global assessment of the impact of ENSO variability on river discharge; these analyses are ongoing. Of course, this approach entails its own problems; the use of global hydrological models to derive daily discharge time

  20. Development, Production and Validation of the NOAA Solar Irradiance Climate Data Record

    NASA Astrophysics Data System (ADS)

    Coddington, O.; Lean, J.; Pilewskie, P.; Snow, M. A.; Lindholm, D. M.

    2015-12-01

    A new climate data record of Total Solar Irradiance (TSI) and Solar Spectral Irradiance (SSI), including source code and supporting documentation is now publicly available as part of the National Oceanographic and Atmospheric Administration's (NOAA) National Centers for Environmental Information (NCEI) Climate Data Record (CDR) Program. Daily and monthly averaged values of TSI and SSI, with associated time and wavelength dependent uncertainties, are estimated from 1882 to the present with yearly averaged values since 1610, updated quarterly for the foreseeable future. The new Solar Irradiance Climate Data Record, jointly developed by the University of Colorado at Boulder's Laboratory for Atmospheric and Space Physics (LASP) and the Naval Research Laboratory (NRL), is constructed from solar irradiance models that determine the changes from quiet Sun conditions when bright faculae and dark sunspots are present on the solar disk. The magnitudes of the irradiance changes that these features produce are determined from linear regression of the proxy Mg II index and sunspot area indices against the approximately decade-long solar irradiance measurements made by instruments on the SOlar Radiation and Climate Experiment (SORCE) spacecraft. We describe the model formulation, uncertainty estimates, operational implementation and validation approach. Future efforts to improve the uncertainty estimates of the Solar Irradiance CDR arising from model assumptions, and augmentation of the solar irradiance reconstructions with direct measurements from the Total and Spectral Solar Irradiance Sensor (TSIS: launch date, July 2017) are also discussed.

  1. Intent to quit among daily and non-daily college student smokers

    PubMed Central

    Pinsker, E. A.; Berg, C. J.; Nehl, E. J.; Prokhorov, A. V.; Buchanan, T. S.; Ahluwalia, J. S.

    2013-01-01

    Given the high prevalence of young adult smoking, we examined (i) psychosocial factors and substance use among college students representing five smoking patterns and histories [non-smokers, quitters, native non-daily smokers (i.e. never daily smokers), converted non-daily smokers (i.e. former daily smokers) and daily smokers] and (ii) smoking category as it relates to readiness to quit among current smokers. Of the 4438 students at six Southeast colleges who completed an online survey, 69.7% (n = 3094) were non-smokers, 6.6% (n = 293) were quitters, 7.1% (n = 317) were native non-daily smokers, 6.4% (n = 283) were converted non-daily smokers and 10.2% (n = 451) were daily smokers. There were differences in sociodemographics, substance use (alcohol, marijuana, other tobacco products) in the past 30 days and psychosocial factors among these subgroups of students (P < 0.001). Among current smokers, there were differences in cigarettes smoked per day, recent quit attempts, self-identification as a smoker, self-efficacy and motivation to quit (P < 0.001). After controlling for important factors, converted non-daily smokers were more likely to be ready to quit in the next month versus native non-daily smokers (OR = 2.15, CI 1.32–3.49, P = 0.002). Understanding differences among young adults with different smoking patterns and histories is critical in developing interventions targeting psychosocial factors impacting cessation among this population. PMID:23197630

  2. A New method for identifying possible causal relationships between CO2, total solar irradiance and global temperature change

    NASA Astrophysics Data System (ADS)

    Seip, Knut L.; Grøn, Øyvind

    2017-02-01

    We apply a novel method based upon "before" and "after" relationships to investigate and quantify interconnections between global temperature anomaly (GTA), as response variable, and greenhouse gases (CO2) and total solar irradiance (TSI) as candidate causal variables for the period 1880 to 2010. The most likely interpretations of our results for the 6 to 8 years cyclic components of the variables are that during the period 1929 to 1936, CO2 significantly leads GTA. However, during the period 1960-2003, GTA apparently leads CO2, that is, the peaks (and troughs) in GTA are in front of, and close to, the peaks (and troughs) in CO2. For time windows outside these periods, we did not find significant before or after-relations. An alternative interpretation is that there is a shift between short (≈1.5 year) and long (≈5 years) durations between cause and effect. Relationships between GTA and TSI suggest that "inertia" of the global sea, land, and atmosphere system leads to delays longer than half their common cycle length of about 10 years. Based on the interaction patterns between the variables GTA, CO2, and TSI, we suggest the possibility that a new regime for how the variables interact started around 1960. From trend forms, and not considering physical mechanisms, we found that the trend in CO2 contributes ≈ 90 %, and the trend in TSI ≈ 10 %, to the trend in GTA during the last 130 years.

  3. Exercise contagion in a global social network.

    PubMed

    Aral, Sinan; Nicolaides, Christos

    2017-04-18

    We leveraged exogenous variation in weather patterns across geographies to identify social contagion in exercise behaviours across a global social network. We estimated these contagion effects by combining daily global weather data, which creates exogenous variation in running among friends, with data on the network ties and daily exercise patterns of ∼1.1M individuals who ran over 350M km in a global social network over 5 years. Here we show that exercise is socially contagious and that its contagiousness varies with the relative activity of and gender relationships between friends. Less active runners influence more active runners, but not the reverse. Both men and women influence men, while only women influence other women. While the Embeddedness and Structural Diversity theories of social contagion explain the influence effects we observe, the Complex Contagion theory does not. These results suggest interventions that account for social contagion will spread behaviour change more effectively.

  4. Solar Irradiance, Plage and SOHO UV Images

    NASA Astrophysics Data System (ADS)

    Lopresto, James C.; Manross, Kevin

    1996-05-01

    Calcium K and H alpha plage and sunspot area have been monitored using Big Bear Observatory images on the INTERNET since November of 1992. The purpose of the project is to determine the correlation of changing plage area and solar irradiance changes. We also monitor changes in the K2 spec- tral index provided daily from Sacramento Peak. With the recent launching of the SOHO satellite, we are able to monitor the plage in the He II 304 Angstroms UV image. This image is near the top of the chromosphere nar or just under the transition region. The images show limb brightening as expected. Since it is widely believed that short time scale changes in the UV may be the dominant cause for low amplitude solar irradiance changes, the comparison of the "plage" ara in these UV images to those in conventional visible images should prove instructive.

  5. Magnitude of Interfractional Vaginal Cuff Movement: Implications for External Irradiation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ma, Daniel J.; Michaletz-Lorenz, Martha; Goddu, S. Murty

    2012-03-15

    Purpose: To quantify the extent of interfractional vaginal cuff movement in patients receiving postoperative irradiation for cervical or endometrial cancer in the absence of bowel/bladder instruction. Methods and Materials: Eleven consecutive patients with cervical or endometrial cancer underwent placement of three gold seed fiducial markers in the vaginal cuff apex as part of standard of care before simulation. Patients subsequently underwent external irradiation and brachytherapy treatment based on institutional guidelines. Daily megavoltage CT imaging was performed during each external radiation treatment fraction. The daily positions of the vaginal apex fiducial markers were subsequently compared with the original position of themore » fiducial markers on the simulation CT. Composite dose-volume histograms were also created by summing daily target positions. Results: The average ({+-} standard deviation) vaginal cuff movement throughout daily pelvic external radiotherapy when referenced to the simulation position was 16.2 {+-} 8.3 mm. The maximum vaginal cuff movement for any patient during treatment was 34.5 mm. In the axial plane the mean vaginal cuff movement was 12.9 {+-} 6.7 mm. The maximum vaginal cuff axial movement was 30.7 mm. In the craniocaudal axis the mean movement was 10.3 {+-} 7.6 mm, with a maximum movement of 27.0 mm. Probability of cuff excursion outside of the clinical target volume steadily dropped as margin size increased (53%, 26%, 4.2%, and 1.4% for 1.0, 1.5, 2.0, and 2.5 cm, respectively.) However, rectal and bladder doses steadily increased with larger margin sizes. Conclusions: The magnitude of vaginal cuff movement is highly patient specific and can impact target coverage in patients without bowel/bladder instructions at simulation. The use of vaginal cuff fiducials can help identify patients at risk for target volume excursion.« less

  6. Daily social interactions, close relationships, and systemic inflammation in two samples: Healthy middle-aged and older adults.

    PubMed

    Bajaj, Amoha; John-Henderson, Neha A; Cundiff, Jenny M; Marsland, Anna L; Manuck, Stephen B; Kamarck, Thomas W

    2016-11-01

    Systemic inflammation is thought to be a biological mediator between social relationship quality and premature mortality. Empirical work has yielded mixed support for an association of social relationship variables with systemic inflammation, perhaps due to methodological limitations. To date, research in this literature has focused on global perceptions of social relationships, with limited attention to the covariance of characteristics of daily social interactions with inflammation. Here, we examine whether daily interactions, as assessed by ecological momentary assessment (EMA), associate with peripheral markers of inflammation among midlife and older adults. Global social support and integration were measured using the Interpersonal Support Evaluation List (ISEL) and the Social Network Index (SNI), respectively, in older adults from the Pittsburgh Healthy Heart Project (PHHP), and in middle-aged adults from the Adult Health and Behavior Project-II (AHAB-II). Using time-sampled EMA, we assessed the proportion of the day spent in positive and negative social interactions. Systemic markers of inflammation were interleukin (IL)-6 and C-reactive protein (CRP). Global measures of support and integration did not associate with inflammation in either sample. In older adults, relative frequency of total positive interactions, those with close others (i.e. spouse, friends, family), and those with coworkers predicted lower concentrations of IL-6 in fully adjusted models, accounting for age, sex, race, education, BMI, smoking and alcohol. In middle-aged adults, relative frequency of positive interactions with close others was also inversely associated with IL-6 level and relative frequency of negative marital interactions was unexpectedly inversely associated with CRP level. Characteristics of daily social interactions among midlife and older adults associate with markers of systemic inflammation that are known to predict risk for cardiovascular disease. Ambulatory

  7. Spatiotemporal variations in the difference between satellite-observed daily maximum land surface temperature and station-based daily maximum near-surface air temperature

    NASA Astrophysics Data System (ADS)

    Lian, Xu; Zeng, Zhenzhong; Yao, Yitong; Peng, Shushi; Wang, Kaicun; Piao, Shilong

    2017-02-01

    There is an increasing demand to integrate land surface temperature (LST) into climate research due to its global coverage, which requires a comprehensive knowledge of its distinctive characteristics compared to near-surface air temperature (Tair). Using satellite observations and in situ station-based data sets, we conducted a global-scale assessment of the spatial and seasonal variations in the difference between daily maximum LST and daily maximum Tair (δT, LST - Tair) during 2003-2014. Spatially, LST is generally higher than Tair over arid and sparsely vegetated regions in the middle-low latitudes, but LST is lower than Tair in tropical rainforests due to strong evaporative cooling, and in the high-latitude regions due to snow-induced radiative cooling. Seasonally, δT is negative in tropical regions throughout the year, while it displays a pronounced seasonality in both the midlatitudes and boreal regions. The seasonality in the midlatitudes is a result of the asynchronous responses of LST and Tair to the seasonal cycle of radiation and vegetation abundance, whereas in the boreal regions, seasonality is mainly caused by the change in snow cover. Our study identified substantial spatial heterogeneity and seasonality in δT, as well as its determinant environmental drivers, and thus provides a useful reference for monitoring near-surface air temperature changes using remote sensing, particularly in remote regions.

  8. Decadal changes in shortwave irradiance at the surface in the period from 1960 to 2000 estimated from Global Energy Balance Archive Data

    NASA Astrophysics Data System (ADS)

    Gilgen, H.; Roesch, A.; Wild, M.; Ohmura, A.

    2009-05-01

    Decadal changes in shortwave irradiance at the Earth's surface are estimated for the period from approximately 1960 through to 2000 from pyranometer records stored in the Global Energy Balance Archive. For this observational period, estimates could be calculated for a total of 140 cells of the International Satellite Cloud Climatology Project grid (an equal area 2.5° × 2.5° grid at the equator) using regression models allowing for station effects. In large regions worldwide, shortwave irradiance decreases in the first half of the observational period, recovers from the decrease in the 1980s, and thereafter increases, in line with previous reports. Years of trend reversals are determined for the grid cells which are best described with a second-order polynomial model. This reversal of the trend is observed in the majority of the grid cells in the interior of Europe and in Japan. In China, shortwave irradiance recovers during the 1990s in the majority of the grid cells in the southeast and northeast from the decrease observed in the period from 1960 through to 1990. A reversal of the trend in the 1980s or early 1990s is also observed for two grid cells in North America, and for the grid cells containing the Kuala Lumpur (Malaysia), Singapore, Casablanca (Morocco), Valparaiso (Chile) sites, and, noticeably, the remote South Pole and American Samoa sites. Negative trends persist, i.e., shortwave radiation decreases, for the observational period 1960 through to 2000 at the European coasts, in central and northwest China, and for three grid cells in India and two in Africa.

  9. Uncertainty and sensitivity analysis for photovoltaic system modeling.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hansen, Clifford W.; Pohl, Andrew Phillip; Jordan, Dirk

    2013-12-01

    We report an uncertainty and sensitivity analysis for modeling DC energy from photovoltaic systems. We consider two systems, each comprised of a single module using either crystalline silicon or CdTe cells, and located either at Albuquerque, NM, or Golden, CO. Output from a PV system is predicted by a sequence of models. Uncertainty in the output of each model is quantified by empirical distributions of each model's residuals. We sample these distributions to propagate uncertainty through the sequence of models to obtain an empirical distribution for each PV system's output. We considered models that: (1) translate measured global horizontal, directmore » and global diffuse irradiance to plane-of-array irradiance; (2) estimate effective irradiance from plane-of-array irradiance; (3) predict cell temperature; and (4) estimate DC voltage, current and power. We found that the uncertainty in PV system output to be relatively small, on the order of 1% for daily energy. Four alternative models were considered for the POA irradiance modeling step; we did not find the choice of one of these models to be of great significance. However, we observed that the POA irradiance model introduced a bias of upwards of 5% of daily energy which translates directly to a systematic difference in predicted energy. Sensitivity analyses relate uncertainty in the PV system output to uncertainty arising from each model. We found that the residuals arising from the POA irradiance and the effective irradiance models to be the dominant contributors to residuals for daily energy, for either technology or location considered. This analysis indicates that efforts to reduce the uncertainty in PV system output should focus on improvements to the POA and effective irradiance models.« less

  10. A Multiyear Dataset of SSM/I-Derived Global Ocean Surface Turbulent Fluxes

    NASA Technical Reports Server (NTRS)

    Chou, Shu-Hsien; Shie, Chung-Lin; Atlas, Robert M.; Ardizzone, Joe; Nelkin, Eric; Einaudi, Franco (Technical Monitor)

    2001-01-01

    The surface turbulent fluxes of momentum, latent heat, and sensible heat over global oceans are essential to weather, climate and ocean problems. Evaporation is a key component of the hydrological cycle and the surface heat budget, while the wind stress is the major forcing for driving the oceanic circulation. The global air-sea fluxes of momentum, latent and sensible heat, radiation, and freshwater (precipitation-evaporation) are the forcing for driving oceanic circulation and, hence, are essential for understanding the general circulation of global oceans. The global air-sea fluxes are required for driving ocean models and validating coupled ocean-atmosphere global models. We have produced a 7.5-year (July 1987-December 1994) dataset of daily surface turbulent fluxes over the global oceans from the Special Sensor microwave/Imager (SSM/I) data. Daily turbulent fluxes were derived from daily data of SSM/I surface winds and specific humidity, National Centers for Environmental Prediction (NCEP) sea surface temperatures, and European Centre for Medium-Range Weather Forecasts (ECMWF) air-sea temperature differences, using a stability-dependent bulk scheme. The retrieved instantaneous surface air humidity (with a 25-km resolution) validated well with that of the collocated radiosonde observations over the global oceans. Furthermore, the retrieved daily wind stresses and latent heat fluxes were found to agree well with that of the in situ measurements (IMET buoy, RV Moana Wave, and RV Wecoma) in the western Pacific warm pool during the TOGA COARE intensive observing period (November 1992-February 1993). The global distributions of 1988-94 seasonal-mean turbulent fluxes will be presented. In addition, the global distributions of 1990-93 annual-means turbulent fluxes and input variables will be compared with those of UWM/COADS covering the same period. The latter is based on the COADS (comprehensive ocean-atmosphere data set) and is recognized to be one of the best

  11. Reconstruction of total and spectral solar irradiance from 1974 to 2013 based on KPVT, SoHO/MDI, and SDO/HMI observations

    NASA Astrophysics Data System (ADS)

    Yeo, K. L.; Krivova, N. A.; Solanki, S. K.; Glassmeier, K. H.

    2014-10-01

    Context. Total and spectral solar irradiance are key parameters in the assessment of solar influence on changes in the Earth's climate. Aims: We present a reconstruction of daily solar irradiance obtained using the SATIRE-S model spanning 1974 to 2013 based on full-disc observations from the KPVT, SoHO/MDI, and SDO/HMI. Methods: SATIRE-S ascribes variation in solar irradiance on timescales greater than a day to photospheric magnetism. The solar spectrum is reconstructed from the apparent surface coverage of bright magnetic features and sunspots in the daily data using the modelled intensity spectra of these magnetic structures. We cross-calibrated the various data sets, harmonizing the model input so as to yield a single consistent time series as the output. Results: The model replicates 92% (R2 = 0.916) of the variability in the PMOD TSI composite including the secular decline between the 1996 and 2008 solar cycle minima. The model also reproduces most of the variability in observed Lyman-α irradiance and the Mg II index. The ultraviolet solar irradiance measurements from the UARS and SORCE missions are mutually consistent up to about 180 nm before they start to exhibit discrepant rotational and cyclical variability, indicative of unresolved instrumental effects. As a result, the agreement between model and measurement, while relatively good below 180 nm, starts to deteriorate above this wavelength. As with earlier similar investigations, the reconstruction cannot reproduce the overall trends in SORCE/SIM SSI. We argue, from the lack of clear solar cycle modulation in the SIM record and the inconsistency between the total flux recorded by the instrument and TSI, that unaccounted instrumental trends are present. Conclusions: The daily solar irradiance time series is consistent with observations from multiple sources, demonstrating its validity and utility for climate models. It also provides further evidence that photospheric magnetism is the prime driver of

  12. Impact of electron beam irradiation on quality of sea buckthorn (Hippophae rhamnoides L.) oil.

    PubMed

    Nemţanu, Monica R; Braşoveanu, Mirela

    2016-03-30

    Sea buckthorn oil is a valuable product that can be incorporated into daily foodstuffs, cosmetics or pharmaceuticals. The effect of accelerated electron irradiation up to 8 kGy on quality characteristics of sea buckthorn oil was investigated in this study. Irradiation had no significant influence on phenolic content. Conversely, carotenoid content, antioxidant activity, and oxidative status suffered alterations as the irradiation dose increased. Although no colour changes were visible for oil irradiated up to 3 kGy, the total colour difference indicated clearly changes that involved a two-step pattern associated with slow degradation of oil colour up to 3 kGy, followed by a fast degradation up to 8 kGy. Some changes of the oil spectral features related to the frequency and intensity of some bands have been found after irradiation, indicating an alteration of the structural integrity induced by irradiation. The present investigation may be a useful starting point for irradiation processing of food or non-food matrices containing sea buckthorn oil. Thus, sea buckthorn oil safety can be ensured with minimal undesirable changes in its quality by applying irradiation doses up to 3 kGy, which allow control of the microbial contamination depending on microorganism type and initial microbial load. © 2015 Society of Chemical Industry.

  13. Solar Spectral Irradiance Variability in Cycle 24: Model Predictions and OMI Observations

    NASA Technical Reports Server (NTRS)

    Marchenko, S.; DeLand, M.; Lean, J.

    2016-01-01

    Utilizing the excellent stability of the Ozone Monitoring Instrument (OMI), we characterize both short-term (solar rotation) and long-term (solar cycle) changes of the solar spectral irradiance (SSI) between 265-500 nanometers during the ongoing Cycle 24. We supplement the OMI data with concurrent observations from the GOME-2 (Global Ozone Monitoring Experiment - 2) and SORCE (Solar Radiation and Climate Experiment) instruments and find fair-to-excellent agreement between the observations and predictions of the NRLSSI2 (Naval Research Laboratory Solar Spectral Irradiance - post SORCE) and SATIRE-S (the Naval Research Laboratory's Spectral And Total Irradiance REconstruction for the Satellite era) models.

  14. Comparison between satellite and instrumental solar irradiance data at the city of Athens, Greece

    NASA Astrophysics Data System (ADS)

    Markonis, Yannis; Dimoulas, Thanos; Atalioti, Athina; Konstantinou, Charalampos; Kontini, Anna; Pipini, Magdalini-Io; Skarlatou, Eleni; Sarantopoulos, Vasilis; Tzouka, Katerina; Papalexiou, Simon; Koutsoyiannis, Demetris

    2015-04-01

    In this study, we examine and compare the statistical properties of satellite and instrumental solar irradiance data at the capital of Greece, Athens. Our aim is to determine whether satellite data are sufficient for the requirements of solar energy modelling applications. To this end we estimate the corresponding probability density functions, the auto-correlation functions and the parameters of some fitted simple stochastic models. We also investigate the effect of sample size to the variance in the temporal interpolation of daily time series. Finally, as an alternative, we examine if temperature can be used as a better predictor for the daily irradiance non-seasonal component instead of the satellite data. Acknowledgement: This research is conducted within the frame of the undergraduate course "Stochastic Methods in Water Resources" of the National Technical University of Athens (NTUA). The School of Civil Engineering of NTUA provided moral support for the participation of the students in the Assembly.

  15. Variations/Changes in Daily Precipitation Extremes Derived from Satellite-Based Products

    NASA Astrophysics Data System (ADS)

    Gu, G.; Adler, R. F.

    2017-12-01

    Oscillation (PDO) and anthropogenic forcings including the greenhouse-gases (GHG) related warming. Comparisons are also made over global land with the results from two gridded daily rain-gauge products, GPCC Full-record daily (1988-2013) and NOAA/CPC Unified daily (1979-present).

  16. Impacts of Irrigation on Daily Extremes in the Coupled Climate System

    NASA Technical Reports Server (NTRS)

    Puma, Michael J.; Cook, Benjamin I.; Krakauer, Nir; Gentine, Pierre; Nazarenka, Larissa; Kelly, Maxwell; Wada, Yoshihide

    2014-01-01

    Widespread irrigation alters regional climate through changes to the energy and water budgets of the land surface. Within general circulation models, simulation studies have revealed significant changes in temperature, precipitation, and other climate variables. Here we investigate the feedbacks of irrigation with a focus on daily extremes at the global scale. We simulate global climate for the year 2000 with and without irrigation to understand irrigation-induced changes. Our simulations reveal shifts in key climate-extreme metrics. These findings indicate that land cover and land use change may be an important contributor to climate extremes both locally and in remote regions including the low-latitudes.

  17. Efficacy and safety of once-daily metronidazole 1% gel compared with twice-daily azelaic acid 15% gel in the treatment of rosacea.

    PubMed

    Wolf, John E; Kerrouche, Nabil; Arsonnaud, Stephanie

    2006-04-01

    Rosacea is an inflammatory dermatologic disorder characterized by the presence of facial erythema, visible blood vessels, papules, and pustules. The National Rosacea Society has established a classification system that identifies 4 distinct rosacea subtypes based on clinical presentation: erythematotelangiectatic, papulopustular, phymatous, and ocular. The goal of topical therapy for rosacea is to reduce inflammatory lesion counts; decrease intensity of erythema; and reduce symptoms such as stinging, burning, and pruritus. Metronidazole and azelaic acid are thought to reduce the inflammation associated with rosacea by inhibiting the production of reactive oxygen species produced by neutrophils. Both metronidazole 1% gel and azelaic acid 15% gel recently have been approved for the treatment of rosacea. The current study was conducted to compare the once-daily application of metronidazole 1% gel with twice-daily applications of azelaic acid 15% gel for the treatment of patients with moderate rosacea (N=160). Both treatments showed similar reductions in inflammatory lesion counts (77% for metronidazole 1% gel and 80% for azelaic acid 15% gel) and high success rates in both global severity (53.7% vs 56.4% for metronidazole 1% gel and azelaic acid 15% gel, respectively) and erythema (42.7% vs 42.3% for metronidazole 1% gel and azelaic acid 15% gel, respectively). On average, the efficacy (including reduction in erythema) of the once-daily application of metronidazole 1% gel and twice-daily applications of azelaic acid 15% gel were similar.

  18. Toxicological and radiological safety of chicken meat irradiated with 7.5 MeV X-rays

    NASA Astrophysics Data System (ADS)

    Song, Beom-Seok; Lee, Yunjong; Park, Jong-Heum; Kim, Jae-Kyung; Park, Ha-Young; Kim, Dong-Ho; Kim, Chang-Jong; Kang, Il-Jun

    2018-03-01

    This study was conducted to evaluate the toxicological and radiological safety of chicken meat that had been irradiated at 30 kGy with 7.5 MeV X-rays. In a sub-chronic toxicity study, ICR mice were fed X-ray-irradiated chicken meat at 2500 mg/kg body weight daily for 90 days, and no mortality or abnormal clinical signs were observed throughout the study period. However, several hematological and serum biochemical parameters of the ICR mice differed significantly from those in the control group; nevertheless, the observed values were all within the normal range for the respective parameters. In addition, no toxicological effects were determined in male or female mice. Furthermore, no differences in gamma-ray spectrometric patterns were detected between the non-irradiated and irradiated samples, indicating that the radioactivity induced by 7.5 MeV X-ray irradiation was below the detection limit. These results tentatively suggest that chicken meat irradiated with 7.5 MeV X-rays would be safe for human consumption in terms of toxicology and radiology.

  19. Disaggregating from daily to sub-daily rainfall under a future climate

    NASA Astrophysics Data System (ADS)

    Westra, S.; Evans, J.; Mehrotra, R.; Sharma, A.

    2012-04-01

    We describe an algorithm for disaggregating daily rainfall into sub-daily rainfall 'fragments' (continuous fine-resolution rainfall sequences whose total depth sums to the daily rainfall amount) under a future, warmer climate. The basis of the algorithm is re-sample sub-daily fragments from the historical record conditional on the total daily rainfall amount and a range of atmospheric predictors representative of the future climate. The logic is that as the atmosphere warms, future rainfall patterns will be more reflective of historical rainfall patterns which occurred on warmer days at the same location, or at locations which have an atmospheric profile more reflective of expected future conditions. When looking at the scaling from daily to sub-daily rainfall over the historical record, it was found that the relationship varied significantly by season and by location, with rainfall patterns on warmer seasons or at warmer locations typically showing more intense rain falling over shorter periods compared with cooler seasons and stations. Importantly, by regressing against atmospheric covariates such as temperature this effect was almost entirely eliminated, providing a basis for suggesting the approach may be valid when extrapolating sub-daily sequences to a future climate. The method of fragments algorithm was then applied to nine stations around Australia, and showed that when holding the total daily rainfall constant, the maximum intensity of a short duration (6 minute) rainfall increased by between 4.1% and 13.4% per degree change in temperature for the maximum six minute burst, between 3.1% and 6.8% for the maximum one hour burst, and between 1.5% and 3.5% for the fraction of the day with no rainfall. This highlights that a large proportion of the change to the distribution of precipitation in the future is likely to occur at sub-daily timescales, with significant implications for many hydrological systems.

  20. The Latest SORCE Solar Spectral Irradiance Data Release: Inter-Comparison and a First Look at TSIS SIM Measurement.

    NASA Astrophysics Data System (ADS)

    Beland, S.; Sandoval, L.; Vanier, B.; Elliott, J.; Harder, J. W.; Snow, M. A.; Woods, T. N.; Richard, E. C.; Pilewskie, P.

    2017-12-01

    The Spectral Irradiance Monitor (SIM), the SOLar STellar Irradiance Comparison Experiment (SOLSTICE), and the XUV Photometer System (XPS) instruments on board the Solar Radiation and Climate Experiment (SORCE) mission have been taking daily Solar spectral irradiance (SSI) measurements since April 2003. We present the latest data releases from these instruments, describing the improvements in the new datasets and the trends measured during Solar cycles 23 and 24. An inter-comparison of the SSI over the overlapping wavelengths for SIM and SOLSTICE is presented as well as, if the data is available, a comparison with the first light measurements from TSIS-SIM.

  1. Twice-Daily versus Once-Daily Pramipexole Extended Release Dosage Regimens in Parkinson's Disease.

    PubMed

    Yun, Ji Young; Kim, Young Eun; Yang, Hui-Jun; Kim, Han-Joon; Jeon, Beomseok

    2017-01-01

    This open-label study aimed to compare once-daily and twice-daily pramipexole extended release (PER) treatment in Parkinson's disease (PD). PD patients on dopamine agonist therapy, but with unsatisfactory control, were enrolled. Existing agonist doses were switched into equivalent PER doses. Subjects were consecutively enrolled into either once-daily-first or twice-daily-first groups and received the prescribed amount in one or two, respectively, daily doses for 8 weeks. For the second period, subjects switched regimens in a crossover manner. The forty-four patients completed a questionnaire requesting preference during their last visit. We measured the UPDRS-III, Hoehn and Yahr stages (H&Y) in medication-on state, Parkinson's disease sleep scale (PDSS), and Epworth Sleepiness Scale. Eighteen patients preferred a twice-daily regimen, 12 preferred a once-daily regimen, and 14 had no preference. After the trial, 14 subjects wanted to be on a once-daily regimen, 25 chose a twice-daily regimen, and 5 wanted to maintain the prestudy regimen. Main reasons for choosing the twice-daily regimen were decreased off-duration, more tolerable off-symptoms, and psychological stability. The mean UPDRS-III, H&Y, and PDSS were not different. Daytime sleepiness was significantly high in the once-daily regimen, whereas nocturnal hallucinations were more common in the twice-daily. Multiple dosing should be considered if once-daily dosing is unsatisfactory. This study is registered as NCT01515774 at ClinicalTrials.gov.

  2. Cranial irradiation in children with lymphoblastic acute leukemia: results and damages. [Incidence of asthenia, anorexia, somnolence, and lethergy as related to irradiation procedure

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Cecchetti, E.; Brandoli, V.

    1979-03-01

    From 1973 to 1976, 81 children with lymphoblastic acute leukemia were treated with cranial prophylactic irradiation at the Istituto di Radioterapia ''L. Galvani'' del'Universita di Bologna. We divided the patients into 6 groups according to different characteristics. At the beginning of 1978 the survival rate was 82%; 60 patients (74%) were in complete continuous remission. We studied the encephalic post irradiation syndrome that is present in children over 2 years of age only when doses are higher than 2500 rad and in children under 2 years of age when doses exceed 2000 rad. This complication occurs frequently in the experiencemore » of other authors; however, it is absent under certain doses with which it is possible to obtain the same good results. We feel that among the different techniques and methods, the best radiological treatment is daily bilateral cranial irradiation for patients early in remission; we recommend doses of 2400 rad for children above 2 years of age and 1950 rad for those under 2 years.« less

  3. Daily spectral energy conversions of the global circulation during 10-27 January 1979

    NASA Technical Reports Server (NTRS)

    Huang, Huo-Jin; Vincent, Dayton G.

    1988-01-01

    A modified version of ECMWF Level III-b analyses is used to examine the energetics of the daily low and middle latitude wave activity that occurred over the globe during part of FGGE. The results indicate that the eddy available potential is increased by sensible heat transport down the temperature gradient at all wavenumbers; it is immediately converted to eddy kinetic energy through warmer air rising and/or colder air sinking. In the present study, particular attention is given to Southern Hemispheric energetics.

  4. Evaluation of different models to estimate the global solar radiation on inclined surface

    NASA Astrophysics Data System (ADS)

    Demain, C.; Journée, M.; Bertrand, C.

    2012-04-01

    Global and diffuse solar radiation intensities are, in general, measured on horizontal surfaces, whereas stationary solar conversion systems (both flat plate solar collector and solar photovoltaic) are mounted on inclined surface to maximize the amount of solar radiation incident on the collector surface. Consequently, the solar radiation incident measured on a tilted surface has to be determined by converting solar radiation from horizontal surface to tilted surface of interest. This study evaluates the performance of 14 models transposing 10 minutes, hourly and daily diffuse solar irradiation from horizontal to inclined surface. Solar radiation data from 8 months (April to November 2011) which include diverse atmospheric conditions and solar altitudes, measured on the roof of the radiation tower of the Royal Meteorological Institute of Belgium in Uccle (Longitude 4.35°, Latitude 50.79°) were used for validation purposes. The individual model performance is assessed by an inter-comparison between the calculated and measured solar global radiation on the south-oriented surface tilted at 50.79° using statistical methods. The relative performance of the different models under different sky conditions has been studied. Comparison of the statistical errors between the different radiation models in function of the clearness index shows that some models perform better under one type of sky condition. Putting together different models acting under different sky conditions can lead to a diminution of the statistical error between global measured solar radiation and global estimated solar radiation. As models described in this paper have been developed for hourly data inputs, statistical error indexes are minimum for hourly data and increase for 10 minutes and one day frequency data.

  5. Predictors of Daily Relationship Quality in Mothers of Children with Autism Spectrum Disorder

    ERIC Educational Resources Information Center

    Timmons, Lisa; Willis, Kelcie D.; Pruitt, Megan M.; Ekas, Naomi V.

    2016-01-01

    Mothers of children with autism spectrum disorder (n = 70) completed online measures of global constructs (i.e., stable individual characteristics measured at time 1), which included resilience, depressive symptoms, and family functioning, followed by 14 daily questionnaires assessing relationship quality and affect on a given day. The global…

  6. Changes to the temporal distribution of daily precipitation

    NASA Astrophysics Data System (ADS)

    Rajah, Kailash; O'Leary, Tess; Turner, Alice; Petrakis, Gabriella; Leonard, Michael; Westra, Seth

    2014-12-01

    Changes to the temporal distribution of daily precipitation were investigated using a data set of 12,513 land-based stations from the Global Historical Climatology Network. The distribution of precipitation was measured using the Gini index (which describes how uniformly precipitation is distributed throughout a year) and the annual number of wet days. The Mann-Kendall test and a regression analysis were used to assess the direction and rate of change to both indices. Over the period of 1976-2000, East Asia, Central America, and Brazil exhibited a decrease in the number of both wet and light precipitation days, and eastern Europe exhibited a decrease in the number of both wet and moderate precipitation days. In contrast, the U.S., southern South America, western Europe, and Australia exhibited an increase in the number of both wet and light precipitation days. Trends in both directions were field significant at the global scale.

  7. Reconstruction of spectral solar irradiance since 1700 from simulated magnetograms

    NASA Astrophysics Data System (ADS)

    Dasi-Espuig, M.; Jiang, J.; Krivova, N. A.; Solanki, S. K.; Unruh, Y. C.; Yeo, K. L.

    2016-05-01

    Aims: We present a reconstruction of the spectral solar irradiance since 1700 using the SATIRE-T2 (Spectral And Total Irradiance REconstructions for the Telescope era version 2) model. This model uses as input magnetograms simulated with a surface flux transport model fed with semi-synthetic records of emerging sunspot groups. Methods: The record of sunspot group areas and positions from the Royal Greenwich Observatory (RGO) is only available since 1874. We used statistical relationships between the properties of sunspot group emergence, such as the latitude, area, and tilt angle, and the sunspot cycle strength and phase to produce semi-synthetic sunspot group records starting in the year 1700. The semi-synthetic records are fed into a surface flux transport model to obtain daily simulated magnetograms that map the distribution of the magnetic flux in active regions (sunspots and faculae) and their decay products on the solar surface. The magnetic flux emerging in ephemeral regions is accounted for separately based on the concept of extended cycles whose length and amplitude are linked to those of the sunspot cycles through the sunspot number. The magnetic flux in each surface component (sunspots, faculae and network, and ephemeral regions) was used to compute the spectral and total solar irradiance (TSI) between the years 1700 and 2009. This reconstruction is aimed at timescales of months or longer although the model returns daily values. Results: We found that SATIRE-T2, besides reproducing other relevant observations such as the total magnetic flux, reconstructs the TSI on timescales of months or longer in good agreement with the PMOD composite of observations, as well as with the reconstruction starting in 1878 based on the RGO-SOON data. The model predicts an increase in the TSI of 1.2+0.2-0.3 Wm-2 between 1700 and the present. The spectral irradiance reconstruction is in good agreement with the UARS/SUSIM measurements as well as the Lyman-α composite. The

  8. Estimating daily global solar radiation by day of the year in Algeria

    NASA Astrophysics Data System (ADS)

    Aoun, Nouar; Bouchouicha, Kada

    2017-05-01

    This study presents six empirical models based on the day-of-the-year number for estimating global solar radiation on a horizontal surface. For this case study, 21 years of experimental data sets for 21 cities over the whole Algerian territory are utilized to develop these models for each city and for all of Algeria. In this study, the territory of Algeria was divided into four different climatic zones, i.e., Arid, Semi-arid, Highlands and Mediterranean. The accuracy of the all-Algeria model was tested for each city and for each climate zone. To evaluate the accuracy of the models, the RMSE, rRMSE, MABE, MAPE, and R, which are the most commonly applied statistical parameters, were utilized. The results show that the six developed models provide excellent predictions for global solar radiation for each city and for all-Algeria. Furthermore, the model showing the greatest accuracy is the sine and cosine wave trigonometric model.

  9. Adolescent daily and general maladjustment: is there reactivity to daily repeated measures methodologies?

    PubMed

    Nishina, Adrienne

    2012-01-01

    The present study examined whether repeated exposure to daily surveys about negative social experiences predicts changes in adolescents' daily and general maladjustment, and whether question content moderates these changes. Across a 2-week period, 6th-grade students (N = 215; mode age = 11) completed 5 daily reports tapping experienced or experienced and witnessed negative events, or they completed no daily reports. General maladjustment was measured in 2-week intervals before, at the end of, and 2 weeks after the daily report study. Daily maladjustment either decreased or did not change across the 5 daily report exposures. General maladjustment decreased across the three 2-week intervals. Combined, results indicate that short-term daily report studies do not place youth at risk for increased maladjustment. © 2012 The Authors. Child Development © 2012 Society for Research in Child Development, Inc.

  10. The Global Streamflow Indices and Metadata archive (G-SIM): A compilation of global streamflow time series indices and meta-data

    NASA Astrophysics Data System (ADS)

    Do, Hong; Gudmundsson, Lukas; Leonard, Michael; Westra, Seth; Senerivatne, Sonia

    2017-04-01

    In-situ observations of daily streamflow with global coverage are a crucial asset for understanding large-scale freshwater resources which are an essential component of the Earth system and a prerequisite for societal development. Here we present the Global Streamflow Indices and Metadata archive (G-SIM), a collection indices derived from more than 20,000 daily streamflow time series across the globe. These indices are designed to support global assessments of change in wet and dry extremes, and have been compiled from 12 free-to-access online databases (seven national databases and five international collections). The G-SIM archive also includes significant metadata to help support detailed understanding of streamflow dynamics, with the inclusion of drainage area shapefile and many essential catchment properties such as land cover type, soil and topographic characteristics. The automated procedure in data handling and quality control of the project makes G-SIM a reproducible, extendible archive and can be utilised for many purposes in large-scale hydrology. Some potential applications include the identification of observational trends in hydrological extremes, the assessment of climate change impacts on streamflow regimes, and the validation of global hydrological models.

  11. Status of FeCrAl ODS Irradiations in the High Flux Isotope Reactor

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Field, Kevin G.; Howard, Richard H.

    2016-08-19

    FeCrAl oxide-dispersion strengthened (ODS) alloys are an attractive sub-set alloy class of the more global FeCrAl material class for nuclear applications due to their high-temperature steam oxidation resistance and hypothesized enhanced radiation tolerance. A need currently exists to determine the radiation tolerance of these newly developed alloys. To address this need, a preliminary study was conducted using the High Flux Isotope Reactor (HFIR) to irradiate an early generation FeCrAl ODS alloy, 125YF. Preliminary post-irradiation examination (PIE) on these irradiated specimens have shown good radiation tolerance at elevated temperatures (≥330°C) but possible radiation-induced hardening and embrittlement at irradiations of 200°C tomore » a damage level of 1.9 displacement per atom (dpa). Building on this experience, a new series of irradiations are currently being conceptualized. This irradiation series called the FCAD irradiation program will irradiate the latest generation FeCrAl ODS and FeCr ODS alloys to significantly higher doses. These experiments will provide the necessary information to determine the mechanical performance of irradiated FeCrAl ODS alloys at light water reactor and fast reactor conditions.« less

  12. An Expanded UV Irradiance Database from TOMS Including the Effects of Ozone, Clouds, and Aerosol Attenuation

    NASA Technical Reports Server (NTRS)

    Herman, J.; Krotkov, N.

    2003-01-01

    The TOMS UV irradiance database (1978 to 2003) has been expanded to include five new products (noon irradiance at 305,310,324, and 380 nm, and noon erythemal-weighted irradiance), in addition to the existing erythemal daily exposure, that permit direct comparisons with ground-based measurements from spectrometers and broadband instruments. The new data are available on http://toms.gsfc.nasa.gov/>http://toms.gsfc.nasa.gov. Comparisons of the TOMS estimated irradiances with ground-based instruments are given along with a review of the sources of known errors, especially the recent improvements in accounting for aerosol attenuation. Trend estimations from the new TOMS irradiances permit the clear separation of changes caused by ozone and those caused by aerosols and clouds. Systematic differences in cloud cover are shown to be the most important factor in determining regional differences in UV radiation reaching the ground for locations at the same latitude (e.g., the summertime differences between Australia and the US southwest).

  13. A semiparametric spatio-temporal model for solar irradiance data

    DOE PAGES

    Patrick, Joshua D.; Harvill, Jane L.; Hansen, Clifford W.

    2016-03-01

    Here, we evaluate semiparametric spatio-temporal models for global horizontal irradiance at high spatial and temporal resolution. These models represent the spatial domain as a lattice and are capable of predicting irradiance at lattice points, given data measured at other lattice points. Using data from a 1.2 MW PV plant located in Lanai, Hawaii, we show that a semiparametric model can be more accurate than simple interpolation between sensor locations. We investigate spatio-temporal models with separable and nonseparable covariance structures and find no evidence to support assuming a separable covariance structure. These results indicate a promising approach for modeling irradiance atmore » high spatial resolution consistent with available ground-based measurements. Moreover, this kind of modeling may find application in design, valuation, and operation of fleets of utility-scale photovoltaic power systems.« less

  14. Children as Global Citizens: A Socratic Approach to Teaching Character

    ERIC Educational Resources Information Center

    Helterbran, Valeri R.; Strahler, Brianna R.

    2013-01-01

    Educators around the world are being challenged to promote positive global citizenship skills in the face of daily news concerning widespread discord, dissonance, injustice, and corruption. This article describes a Socratic approach to developing global citizenship. Recognizing the central role of teachers in educating future generations of a…

  15. Comparative Flight Activities and Pathogen Load of Two Stocks of Honey Bees Reared in Gamma-Irradiated Combs

    PubMed Central

    de Guzman, Lilia I.; Frake, Amanda M.

    2017-01-01

    Gamma irradiation is known to inactivate various pathogens that negatively affect honey bee health. Bee pathogens, such as Deformed wing virus (DWV) and Nosema spp., have a deleterious impact on foraging activities and bee survival, and have been detected in combs. In this study, we assessed the effects of gamma irradiation on the flight activities, pathogen load, and survival of two honey bee stocks that were reared in irradiated and non-irradiated combs. Overall, bee genotype influenced the average number of daily flights, the total number of foraging flights, and total flight duration, in which the Russian honey bees outperformed the Italian honey bees. Exposing combs to gamma irradiation only affected the age at first flight, with worker bees that were reared in non-irradiated combs foraging prematurely compared to those reared in irradiated combs. Precocious foraging may be associated with the higher levels of DWV in bees reared in non-irradiated combs and also with the lower amount of pollen stores in colonies that used non-irradiated combs. These data suggest that gamma irradiation of combs can help minimize the negative impact of DWV in honey bees. Since colonies with irradiated combs stored more pollen than those with non-irradiated combs, crop pollination efficiency may be further improved when mite-resistant stocks are used, since they performed more flights and had longer flight durations. PMID:29186033

  16. A Daily Analysis of Physical Activity and Satisfaction with Life in Emerging Adults

    PubMed Central

    Maher, Jaclyn P.; Doerksen, Shawna E.; Elavsky, Steriani; Hyde, Amanda L.; Pincus, Aaron L.; Ram, Nilam; Conroy, David E.

    2014-01-01

    Objective Subjective well-being has well-established positive health consequences. During emerging adulthood, from ages 18 to 25 years, people’s global evaluations of their well-being (i.e., satisfaction with life [SWL]) appear to worsen more than any other time in the adult lifespan, indicating that this population would benefit from strategies to enhance SWL. In these studies, we investigated top-down (i.e., time-invariant, trait-like) and bottom-up (i.e., time-varying, state-like) influences of physical activity (PA) on daily SWL. Methods Two daily diary studies lasting 8 days (N = 190) and 14 days (N = 63) were conducted with samples of emerging adults enrolled in college to evaluate relations between daily PA and SWL while controlling for established and plausible top-down and bottom-up influences on SWL. Results In both studies, multilevel models indicated that people reported greater SWL on days when they were more active (a within-person, bottom-up effect). Top-down effects of PA were not significant in either study. These findings were robust when we controlled for competing top-down influences (e.g., sex, personality traits, self-esteem, body mass index, mental health symptoms, fatigue) and bottom-up influences (e.g., daily self-esteem, daily mental health symptoms, daily fatigue). Conclusions We concluded that SWL was impacted by people’s daily PA rather than their trait level of PA over time. These findings extend evidence that PA is a health behavior with important consequences for daily well-being and should be considered when developing national policies to enhance SWL. PMID:23088171

  17. Assessment of VIIRS daily BRDF/Albedo product using in situ measurement of SURFRAD sites and MODIS V006 daily BRDF/Albedo product

    NASA Astrophysics Data System (ADS)

    Liu, Y.; Wang, Z.; Sun, Q.; Schaaf, C.; Roman, M. O.

    2014-12-01

    Surface albedo is defined as the ratio of upwelling to downwelling radiative flux. It's important for understanding the global energy budget. Remote sensing albedo products provide global time continuous coverage to help capture global energy variability and change. The Visible Infrared Imaging Radiometer Suite (VIIRS) on the Suomi-NPP satellite, launched on October 28, 2011, is aiming to provide continues data record with the MODerate resolution Imaging Spectroradiometer (MODIS), which has been providing Bidirectional Reflectance Distribution Function (BRDF)/Albedo product since 2000. By utilizing the same approach that was used for the most recently V006 daily MODIS BRDF/Albedo product, VIIRS has the ability to keep providing products for research and operational users. Validating albedo product of VIIRS using in situmeasured albedo can assure the quality for land surface climate and biosphere models, and comparing with MODIS product can assure time continues of BRDF/albedo product. The daily BRDF/Albedo product still uses 16-day period multispectral, cloud-cleared, atmospherically-corrected surface reflectances to fit the Ross-Thick/Li-Sparse-Reciprocal semi-empirical BRDF model. But the multiday observations are also weighted based on proximity to the production date in order to emphasis on that individual day. Surface Radiation Budget Network (SURFRAD) was established in 1993 through the support of NOAA's Office of Global Programs. In situ albedo was driven from downwelling and upwelling radiative flux measured from the towers. Fraction of diffuse sky light was calculated using the direct and diffuse solar recorded in the data. It was further used to translate VIIRS, MODIS black sky and white sky albedos into actual albedo at local solar noon. Results show that VIIRS, MODIS and in situ albedo agree well at SURFARD spatially representative sites. While the VIIRS surface reflectance, snow, and cloud algorithms are still undergoing revision, the result shows that

  18. Models of Solar Irradiance Variability and the Instrumental Temperature Record

    NASA Technical Reports Server (NTRS)

    Marcus, S. L.; Ghil, M.; Ide, K.

    1998-01-01

    The effects of decade-to-century (Dec-Cen) variations in total solar irradiance (TSI) on global mean surface temperature Ts during the pre-Pinatubo instrumental era (1854-1991) are studied by using two different proxies for TSI and a simplified version of the IPCC climate model.

  19. Real-world implications of apathy among older adults: Independent associations with activities of daily living and quality of life.

    PubMed

    Tierney, Savanna M; Woods, Steven Paul; Weinborn, Michael; Bucks, Romola S

    2018-03-13

    Apathy is common in older adults and has been linked to adverse health outcomes. The current study examined whether apathy contributes to problems managing activities of daily living (ADLs) and lower quality of life (QoL) in older adults. Participants included 83 community-dwelling older adults. Apathy was assessed using a composite of the self and family-rating scales from the Frontal Systems Behavioral Scale (FrSBe). A knowledgeable informant completed the Activities of Daily Living Questionnaire (ADLQ), and participants completed the World Health Organization Quality of Life (WHOQol) scale. Nominal logistic regressions controlling for age, anxiety and depression symptoms, chronic medical conditions, and global cognition revealed that higher levels of apathy were significantly associated with a wide range of mild ADL problems. In parallel, a multiple linear regression indicated that greater apathy was significantly associated with lower QoL independent of ADL problems, anxious and depressive symptomology, chronic medical conditions, global cognition and age. Findings suggest that apathy confers an increased risk of problems in the independent management of daily activities and poorer well-being among community-dwelling older adults. Neurobehavioral and pharmacological interventions to improve apathy may have beneficial effects on the daily lives of older adults.

  20. Observations of Solar Spectral Irradiance Change During Cycle 22 from NOAA-9 SBUV/2

    NASA Technical Reports Server (NTRS)

    DeLand, Matthew T.; Cebula, Richard P.; Hilsenrath, Ernest

    2003-01-01

    The NOM-9 Solar Backscatter Ultraviolet, model 2 (SBUV/2) instrument is one of a series of instruments providing daily solar spectral irradiance measurements in the middle and near ultraviolet since 1978. The SBUV/2 instruments are primarily designed to measure stratospheric profile and total column ozone, using the directional albedo as the input to the ozone processing algorithm. As a result, the SBUV/2 instrument does not have onboard monitoring of all time-dependent response changes. We have applied internal comparisons and vicarious (external) comparisons to determine the long-term instrument characterization for NOAA-9 SBUV/2 to derive accurate solar spectral irradiances from March 1985 to May 1997 spanning two solar cycle minima with a single instrument. The NOAA-9 data show an amplitude of 9.3(+/- 2.3)% (81-day averaged) at 200-205 nm for solar cycle 22. This is consistent with the result of (Delta)F(sub 200-205) = 8.3(+/- 2.6)% for cycle 21 from Nimbus-7 SBUV and (Delta)F(sub 200-205) = 10(+/- 2)% (daily values) for cycle 23 from UARS SUSIM. NOAA-9 data at 245-250 nm show a solar cycle amplitude of (Delta)F(sub 245-250) = 5.7(+/- 1.8)%. NOAA-9 SBUV/2 data can be combined with other instruments to create a 25-year record of solar UV irradiance.

  1. Effect of infrared laser irradiation on amino acid neurotransmitters in an epileptic animal model induced by pilocarpine.

    PubMed

    Radwan, Nasr Mahmoud; El Hay Ahmed, Nawal Abd; Ibrahim, Khayria Mansour; Khedr, Mona Emam; Aziz, Mona A; Khadrawy, Yasser Ashry

    2009-06-01

    The aim of the present study was to investigate the effect of daily laser irradiation on the levels of amino acid neurotransmitters in the cortex and hippocampus in an epileptic animal model induced by pilocarpine. It has been claimed that at specific wavelengths and energy densities, laser irradiation is a novel and useful tool for the treatment of peripheral and central nervous system injuries and disorders. Adult male albino rats were divided into three groups: control rats, pilocarpinized rats (epileptic animal model), and pilocarpinized rats treated daily with laser irradiation (90 mW at 830 nm) for 7 d. The following parameters were assayed in cortex and hippocampus: amino acid neurotransmitters (excitatory: glutamic acid and aspartate; and inhibitory: gamma-aminobutyric acid [GABA], glycine, and taurine) by high-performance liquid chromatography (HPLC), glucose content, and the activity of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), using a spectrophotometer. Significant increases in the concentrations of glutamic acid, glutamine, glycine, and taurine were recorded in the cortices of pilocarpinized rats, and they returned to initial levels after laser treatment. In the hippocampus, a moderate increase in aspartate accompanied by a significant increase in glycine were observed in the epileptic animal model, and these dropped to near-control values after laser treatment. In addition, a significant increase in cortical AST activity and a significant decrease in ALT activity and glucose content were obtained in the pilocarpinized animals and pilocarpinized rats treated with laser irradiation. In the hippocampus, significant decreases in the activity of AST and ALT and glucose content were recorded in the epileptic animals and in the epileptic animals treated with laser irradiation. Based on the results obtained in this study, it may be suggested that nearinfrared laser irradiation may reverse the neurochemical changes in amino acid

  2. Analysis of the solar radiation data for Beer Sheva, Israel, and its environs

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kudish, A.I.; Ianetz, A.

    The solar radiation climate of Beer Sheva, Israel, is reported upon in detail. The database utilized in this analysis consisted of global radiation on a horizontal surface, normal incidence beam radiation, and global radiation on a south-facing surface tilted at 40{degree}. Monthly-average hourly and daily values are reported for each of these three types of measured radiations, together with the calculated monthly-average daily values for the components of the global radiation, viz. the horizontal beam and diffuse radiations. The monthly-average hourly and daily clearness index values have also been calculated and analyzed. Monthly-average daily frequency distributions of the clearness indexmore » values are reported for each month. The solar radiation climate of Beer Sheva has also been compared to those reported for a number of countries in this region. The annual-average daily global radiation incident on a horizontal surface is 18.91 MG/m{sup 2} and that for normal incidence beam radiation is 21.17 MG/m{sup 2}. The annual-average daily fraction of the horizontal global radiation that is beam is 0.72. The annual-average daily value for the clearness index is 0.587 and the average frequency of clear days annually is 58.6%. The authors conclude, based upon the above analysis, that Beer Sheva and its environs are characterized by relatively high, average-daily irradiation rates, both global and beam, and a relatively high frequency of clear days.« less

  3. First application of hemi-body electron beam irradiation for Kaposi sarcoma at the lower extremities.

    PubMed

    Platoni, Kalliopi; Diamantopoulos, Stefanos; Dilvoi, Maria; Delinikolas, Panagiotis; Kypraiou, Efrosyni; Efstathopoulos, Efstathios; Kouloulias, Vassilis

    2018-01-01

    Kaposi's sarcoma (KS) is a systemic neoplastic disease that can present cutaneous symptoms and is usually treated with a systematic approach due to its extent. Due to its radiosensitivity, radiotherapy is considered one of its main treatments, for palliation and local control of the skin and mucosal lesions. The aim of this paper was to report the first case of KS treated by hemi-body electron irradiation protocol in Greece. A fractionated 40 Gy hemi-body electron irradiation was prescribed to a 60-year-old male patient with KS at his legs. Dose uniformity was verified on a daily basis by thermoluminescence dosimetry (TLD). The treatment resulted to complete clinical response. Limited irradiation-derived side effects appeared. This is the first case ever to be treated with hemi-body electron irradiation protocol in Greece. To the best of our knowledge, this is also the first time that a single field hemi-body electron beam irradiation at a total skin electron beam (TSEB)-like configuration is reported to be used for KS.

  4. Solar Spectral Irradiance and Climate

    NASA Technical Reports Server (NTRS)

    Pilewskie, P.; Woods, T.; Cahalan, R.

    2012-01-01

    Spectrally resolved solar irradiance is recognized as being increasingly important to improving our understanding of the manner in which the Sun influences climate. There is strong empirical evidence linking total solar irradiance to surface temperature trends - even though the Sun has likely made only a small contribution to the last half-century's global temperature anomaly - but the amplitudes cannot be explained by direct solar heating alone. The wavelength and height dependence of solar radiation deposition, for example, ozone absorption in the stratosphere, absorption in the ocean mixed layer, and water vapor absorption in the lower troposphere, contribute to the "top-down" and "bottom-up" mechanisms that have been proposed as possible amplifiers of the solar signal. New observations and models of solar spectral irradiance are needed to study these processes and to quantify their impacts on climate. Some of the most recent observations of solar spectral variability from the mid-ultraviolet to the near-infrared have revealed some unexpected behavior that was not anticipated prior to their measurement, based on an understanding from model reconstructions. The atmospheric response to the observed spectral variability, as quantified in climate model simulations, have revealed similarly surprising and in some cases, conflicting results. This talk will provide an overview on the state of our understanding of the spectrally resolved solar irradiance, its variability over many time scales, potential climate impacts, and finally, a discussion on what is required for improving our understanding of Sun-climate connections, including a look forward to future observations.

  5. A daily wetness index from satellite gravity for near-real time global monitoring of hydrological extremes

    NASA Astrophysics Data System (ADS)

    Gouweleeuw, Ben; Kvas, Andreas; Gruber, Christian; Mayer-Gürr, Torsten; Flechtner, Frank; Hasan, Mehedi; Güntner, Andreas

    2017-04-01

    Since April 2002, the Gravity Recovery and Climate Experiment (GRACE) satellite mission has been churning out water storage anomaly data, which has been shown to be a unique descriptor of large-scale hydrological extreme events. Nonetheless, efforts to assess the comprehensive information from GRACE on total water storage variations for near-real time flood or drought monitoring have been limited so far, primarily due to its coarse temporal (weekly to monthly) and spatial (> 150.000 km2) resolution and the latency of standard products of about 2 months,. Pending the status of the aging GRACE satellite mission, the Horizon 2020 funded EGSIEM (European Gravity Service for Improved Emergency Management) project is scheduled to launch a 6 month duration near-real time test run of GRACE gravity field data from April 2017 onward, which will provide daily gridded data with a latency of 5 days. This fast availability allows the monitoring of total water storage variations related to hydrological extreme events, as they occur, as opposed to a 'confirmation after occurrence', which is the current situation. This contribution proposes a global GRACE-derived gridded wetness indicator, expressed as a gravity anomaly in dimensionless units of standard deviation. Results of a retrospective evaluation (April 2002-December 2015) of the proposed index against databases of hydrological extremes will be presented. It is shown that signals for large extreme floods related to heavy/monsoonal rainfall are picked up really well in the Southern Hemisphere and lower Northern Hemisphere (Africa, S-America, Australia, S-Asia), while extreme floods in the Northern Hemisphere (Russia) related to snow melt are often not. The latter is possibly related to a lack of mass movement over longer distances, e.g. when melt water is not drained due to river ice blocking.

  6. Performance assessment of different day-of-the-year-based models for estimating global solar radiation - Case study: Egypt

    NASA Astrophysics Data System (ADS)

    Hassan, Gasser E.; Youssef, M. Elsayed; Ali, Mohamed A.; Mohamed, Zahraa E.; Shehata, Ali I.

    2016-11-01

    Different models are introduced to predict the daily global solar radiation in different locations but there is no specific model based on the day of the year is proposed for many locations around the world. In this study, more than 20 years of measured data for daily global solar radiation on a horizontal surface are used to develop and validate seven models to estimate the daily global solar radiation by day of the year for ten cities around Egypt as a case study. Moreover, the generalization capability for the best models is examined all over the country. The regression analysis is employed to calculate the coefficients of different suggested models. The statistical indicators namely, RMSE, MABE, MAPE, r and R2 are calculated to evaluate the performance of the developed models. Based on the validation with the available data, the results show that the hybrid sine and cosine wave model and 4th order polynomial model have the best performance among other suggested models. Consequently, these two models coupled with suitable coefficients can be used for estimating the daily global solar radiation on a horizontal surface for each city, and also for all the locations around the studied region. It is believed that the established models in this work are applicable and significant for quick estimation for the average daily global solar radiation on a horizontal surface with higher accuracy. The values of global solar radiation generated by this approach can be utilized in the design and estimation of the performance of different solar applications.

  7. Is This Global Warming? Communicating the Intangibles of Climate Change

    NASA Astrophysics Data System (ADS)

    Warner, L.; Henson, R.

    2004-05-01

    Unlike weather, which is immediate, tangible, and relevant on a daily basis, climate change is long-term, slow to evolve, and often difficult to relate to the public's daily concerns. By explaining global-change research to wide and diverse audiences through a variety of vehicles, including publications, exhibits, Web sites, and television B-roll, UCAR has gained experience and perspective on the challenges involved. This talk will explore some of the lessons learned and some of the key difficulties that face global-change communicators, including: --The lack of definitive findings on regional effects of global change -- The long time frame in which global change plays out, versus the short attention span of media, the public, and policy makers --The use of weather events as news pegs (they pique interest, but they may not be good exemplars of global change and are difficult to relate directly to changes in greenhouse-gas emissions) --The perils of the traditional journalistic technique of point-counterpoint in discussing climate change --The presence of strong personal/political convictions among various interest groups and how these affect the message(s) conveyed

  8. Alterations in Rubisco activity and in stomatal behavior induce a daily rhythm in photosynthesis of aerial leaves in the amphibious-plant Nuphar lutea.

    PubMed

    Snir, Ainit; Gurevitz, Michael; Marcus, Yehouda

    2006-12-01

    Nuphar lutea is an amphibious plant with submerged and aerial foliage, which raises the question how do both leaf types perform photosynthetically in two different environments. We found that the aerial leaves function like terrestrial sun-leaves in that their photosynthetic capability was high and saturated under high irradiance (ca. 1,500 mumol photons m(-2) s(-1)). We show that stomatal opening and Rubisco activity in these leaves co-limited photosynthesis at saturating irradiance fluctuating in a daily rhythm. In the morning, sunlight stimulated stomatal opening, Rubisco synthesis, and the neutralization of a night-accumulated Rubisco inhibitor. Consequently, the light-saturated quantum efficiency and rate of photosynthesis increased 10-fold by midday. During the afternoon, gradual closure of the stomata and a decrease in Rubisco content reduced the light-saturated photosynthetic rate. However, at limited irradiance, stomatal behavior and Rubisco content had only a marginal effect on the photosynthetic rate, which did not change during the day. In contrast to the aerial leaves, the photosynthesis rate of the submerged leaves, adapted to a shaded environment, was saturated under lower irradiance. The light-saturated quantum efficiency of these leaves was much lower and did not change during the day. Due to their low photosynthetic affinity for CO(2) (35 muM) and inability to utilize other inorganic carbon species, their photosynthetic rate at air-equilibrated water was CO(2)-limited. These results reveal differences in the photosynthetic performance of the two types of Nuphar leaves and unravel how photosynthetic daily rhythm in the aerial leaves is controlled.

  9. Results of a Phase 2, Randomized,Vehicle-Controlled Study Evaluating the Efficacy,Tolerability, and Safety of Daily or Twice Daily SB204 for the Treatment of Acne Vulgaris.

    PubMed

    Eichenfield, Lawrence F; Gold, Linda Stein; Nahm, Walter K; Cook-Bolden, Fran E; Pariser, David M

    2016-12-01

    This randomized, double-blind, placebo-controlled, Phase 2 study compared efficacy, tolerability, and safety of SB204 once or twice daily to vehicle in the treatment of acne vulgaris. Eligible subjects were to be between 12 and 40 years old, have facial acne vulgaris with 25 to 70 non-inflammatory lesions, 20 to 40 inflammatory lesions, no more than 2 nodules, and a baseline Investigator's Global Assessment (IGA) score of moderate or severe. The co-primary efficacy endpoints were the absolute change in inflammatory and non-inflammatory lesion counts and IGA success rate (baseline to week 12). Safety assessments included reported adverse events (AEs), physical examinations, and laboratory testing. Tolerability was evaluated by the investigators based on the occurrence and severity of erythema, scaling, dryness, pruritus, and burning/stinging. A total of 213 subjects were randomized: 27 subjects to vehicle once daily; 29 subjects to vehicle twice daily; 53 subjects to SB204 2% twice daily; 52 subjects to SB204 4% once daily; and 52 subjects to SB204 4% twice daily. When compared to vehicle, treatment with all 3 SB204 regimens significantly reduced the absolute inflammatory lesion count and SB204 4% once daily reduced the absolute non-inflammatory lesion count. Treatment with SB204 4% once daily demonstrated a significant reduction in percent inflammatory lesions by week 4. There were no significant differences in the IGA success rates between groups at the end of treatment. All treatment regimens of SB204 were found to be safe and well tolerated. When compared to vehicle, SB204 2% and SB204 4% significantly decreased the absolute inflammatory lesion count and SB204 4% once daily also significantly decreased the absolute non-inflammatory lesion count in subjects with acne vulgaris treated for 12 weeks. Treatment with SB204 2% and 4% was found to be safe and well tolerated. J Drugs Dermatol. 2016;15(12):1496-1502.

  10. Photovoltaic System Modeling. Uncertainty and Sensitivity Analyses

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hansen, Clifford W.; Martin, Curtis E.

    2015-08-01

    We report an uncertainty and sensitivity analysis for modeling AC energy from ph otovoltaic systems . Output from a PV system is predicted by a sequence of models. We quantify u ncertainty i n the output of each model using empirical distribution s of each model's residuals. We propagate uncertainty through the sequence of models by sampli ng these distributions to obtain a n empirical distribution of a PV system's output. We consider models that: (1) translate measured global horizontal, direct and global diffuse irradiance to plane - of - array irradiance; (2) estimate effective irradiance; (3) predict cell temperature;more » (4) estimate DC voltage, current and power ; (5) reduce DC power for losses due to inefficient maximum power point tracking or mismatch among modules; and (6) convert DC to AC power . O ur analysis consider s a notional PV system com prising an array of FirstSolar FS - 387 modules and a 250 kW AC inverter ; we use measured irradiance and weather at Albuquerque, NM. We found the uncertainty in PV syste m output to be relatively small, on the order of 1% for daily energy. We found that unce rtainty in the models for POA irradiance and effective irradiance to be the dominant contributors to uncertainty in predicted daily energy. Our analysis indicates that efforts to reduce the uncertainty in PV system output predictions may yield the greatest improvements by focusing on the POA and effective irradiance models.« less

  11. GROWTH AND DEVELOPMENT OF MICE OFFSPRING AFTER IRRADIATION IN UTERO WITH 2,450-MHZ MICROWAVES

    EPA Science Inventory

    Mice offspring irradiated in utero with 2,450-MHz radio-frequency (RF) radiation at 0 or 28 mW/cm. sq. (whole-body averaged specific absorption rate = 0 or 16.5 W/kg) for 100 minutes daily on days 6 through 17 of gestation were evaluated for maturation and development on days 1, ...

  12. Globalization and the "Identity Remix" among Urban Adolescents in India

    ERIC Educational Resources Information Center

    Rao, Mrinalini A.; Berry, Ruhi; Gonsalves, Ayesha; Hastak, Yogita; Shah, Mukti; Roeser, Robert W.

    2013-01-01

    This study examined adolescents' perceptions of cultural change and identity development during an age of globalization in India. Analyses of data from 1497 Indian, urban, middle-class 12-15-year-olds (46% girls) revealed that these youth were aware of changes in their daily lives due to globalization and evaluated such changes in a pragmatic…

  13. Relationships Among Nightly Sleep Quality, Daily Stress, and Daily Affect

    PubMed Central

    Bergeman, Cindy S.; Whitehead, Brenda R.; Braun, Marcia E.; Payne, Jessic D.

    2017-01-01

    Abstract Objectives. We explored the prospective, microlevel relationship between nightly sleep quality (SQ) and the subsequent day’s stress on positive (PA) and negative affect (NA) as well as the moderating relationships between nightly SQ, subsequent stress, and subsequent PA on NA. We investigated whether age moderated these relationships. Method. We collected 56 days of sleep, stress, and affect data using daily diary questionnaires (N = 552). We used multilevel modeling to assess relationships at the between- and within-person levels. Results. Daily increases in SQ and decreases in stress interacted to predict higher daily PA and lower daily NA. Better SQ in older adults enhanced the benefits of PA on the stress–NA relationship more during times of low stress, whereas better sleep in younger adults enhanced the benefits of PA more during times of high stress. Between-person effects were stronger predictors of well-being outcomes than within-person variability. Discussion. The combination of good SQ and higher PA buffered the impact of stress on NA. The moderating impact of age suggests that sleep and stress play different roles across adulthood. Targeting intervention and prevention strategies to improve SQ and enhance PA could disrupt the detrimental relationship between daily stress and NA. PMID:26307483

  14. Medicare's "Global" terrorism: where is the pay for performance?

    PubMed

    Reed, R Lawrence; Luchette, Fred A; Esposito, Thomas J; Pyrz, Karen; Gamelli, Richard L

    2008-02-01

    Medicare and Medicaid Services (CMS) payment policies for surgical operations are based on a global package concept. CMS' physician fee schedule splits the global package into preoperative, intraoperative, and postoperative components of each procedure. We hypothesized that these global package component valuations were often lower than comparable evaluation and management (E&M) services and that billing for E&M services instead of the operation could often be more profitable. Our billing database and Trauma Registry were queried for the operative procedures and hospital lengths of stay for trauma patients during the past 5 years. Determinations of preoperative, intraoperative, and postoperative payments were calculated for 10-day and 90-day global packages, comparing them to CMS payments for comparable E&M codes. Of 90-day and 10-day Current Procedural Terminology codes, 88% and 100%, respectively, do not pay for the comprehensive history and physical that trauma patients usually receive, whereas 41% and 98%, respectively, do not even meet payment levels for a simple history and physical. Of 90-day global package procedures, 70% would have generated more revenue had comprehensive daily visits been billed instead of the operation ($3,057,500 vs. $1,658,058). For 10-day global package procedures, 56% would have generated more revenue with merely problem-focused daily visits instead of the operation ($161,855 vs. $156,318). Medicare's global surgical package underpays E&M services in trauma patients. In most cases, trauma surgeons would fare better by not billing for operations to receive higher reimbursement for E&M services that are considered "bundled" in the global package payment.

  15. The effect of irradiance on the carbon balance and tissue characteristics of five herbaceous species differing in shade-tolerance

    PubMed Central

    Pons, Thijs L.; Poorter, Hendrik

    2014-01-01

    The carbon balance is defined here as the partitioning of daily whole-plant gross CO2 assimilation (A) in C available for growth and C required for respiration (R). A scales positively with growth irradiance and there is evidence for an irradiance dependence of R as well. Here we ask if R as a fraction of A is also irradiance dependent, whether there are systematic differences in C-balance between shade-tolerant and shade-intolerant species, and what the causes could be. Growth, gas exchange, chemical composition and leaf structure were analyzed for two shade-tolerant and three shade-intolerant herbaceous species that were hydroponically grown in a growth room at five irradiances from 20 μmol m−2 s−1 (1.2 mol m−2 day−1) to 500 μmol m−2 s−1 (30 mol m−2 day−1). Growth analysis showed little difference between species in unit leaf rate (dry mass increase per unit leaf area) at low irradiance, but lower rates for the shade-tolerant species at high irradiance, mainly as a result of their lower light-saturated rate of photosynthesis. This resulted in lower relative growth rates in these conditions. Daily whole-plant R scaled with A in a very tight manner, giving a remarkably constant R/A ratio of around 0.3 for all but the lowest irradiance. Although some shade-intolerant species showed tendencies toward a higher R/A and inefficiencies in terms of carbon and nitrogen investment in their leaves, no conclusive evidence was found for systematic differences in C-balance between the shade-tolerant and intolerant species at the lowest irradiance. Leaf tissue of the shade-tolerant species was characterized by high dry matter percentages, C-concentration and construction costs, which could be associated with a better defense in shade environments where leaf longevity matters. We conclude that shade-intolerant species have a competitive advantage at high irradiance due to superior potential growth rates, but that shade-tolerance is not necessarily associated

  16. Self-critical perfectionism, daily stress, and disclosure of daily emotional events.

    PubMed

    Richardson, Clarissa M E; Rice, Kenneth G

    2015-10-01

    Although disclosure of stressful events can alleviate distress, self-critical perfectionism may pose an especially strong impediment to disclosure during stress, likely contributing to poorer psychological well-being. In the current study, after completing a measure of self-critical perfectionism (the Discrepancy subscale of the Almost Perfect Scale--Revised; Slaney, Rice, Mobley, Trippi, & Ashby, 2001), 396 undergraduates completed measures of stress and disclosure at the end of each day for 1 week. Consistent with hypotheses and previous research, multilevel modeling results indicated significant intraindividual coupling of daily stress and daily disclosure where disclosure was more likely when experiencing high stress than low stress. As hypothesized, Discrepancy moderated the relationship between daily stress and daily disclosure. Individuals higher in self-critical perfectionism (Discrepancy) were less likely to engage in disclosure under high stress, when disclosure is often most beneficial, than those with lower Discrepancy scores. These results have implications for understanding the role of stress and coping in the daily lives of self-critical perfectionists. (c) 2015 APA, all rights reserved).

  17. Daily Temperature and Precipitation Data for 223 Former-USSR Stations (NDP-040)

    DOE Data Explorer

    Razuvaev, V. N. [Russian Research Institute of Hydrometeorological Information-World Data Centre; Apasova, E. B. [Russian Research Institute of Hydrometeorological Information-World Data Centre; Martuganov, R. A. [Russian Research Institute of Hydrometeorological Information-World Data Centre

    1990-01-01

    The stations in this dataset are considered by RIHMI to comprise one of the best networks suitable for temperature and precipitation monitoring over the the former-USSR. Factors involved in choosing these 223 stations included length or record, amount of missing data, and achieving reasonably good geographic coverage. There are indeed many more stations with daily data over this part of the world, and hundreds more station records are available through NOAA's Global Historical Climatology Network - Daily (GHCND) database. The 223 stations comprising this database are included in GHCND, but different data processing, updating, and quality assurance methods/checks mean that the agreement between records will vary depending on the station. The relative quality and accuracy of the common station records in the two databases also cannot be easily assessed. As of this writing, most of the common stations contained in the GHCND have more recent records, but not necessarily records starting as early as the records available here. This database contains four variables: daily mean, minimum, and maximum temperature, and daily total precipitation (liquid equivalent). Temperature were taken three times a day from 1881-1935, four times a day from 1936-65, and eight times a day since 1966. Daily mean temperature is defined as the average of all observations for each calendar day. Daily maximum/minimum temperatures are derived from maximum/minimum thermometer measurements. See the measurement description file for further details. Daily precipitation totals are also available (to the nearest tenth of a millimeter) for each station. Throughout the record, daily precipitation is defined as the total amount of precipitation recorded during a 24-h period, snowfall being converted to a liquid total by melting the snow in the gauge. From 1936 on, rain gauges were checked several times each day; the cumulative total of all observations during a calendar day was presumably used as the

  18. Self-Regulatory Strategies in Daily Life: Selection, Optimization, and Compensation and Everyday Memory Problems

    PubMed Central

    Stephanie, Robinson; Margie, Lachman; Elizabeth, Rickenbach

    2015-01-01

    The effective use of self-regulatory strategies, such as selection, optimization, and compensation (SOC) requires resources. However, it is theorized that SOC use is most advantageous for those experiencing losses and diminishing resources. The present study explored this seeming paradox within the context of limitations or constraints due to aging, low cognitive resources, and daily stress in relation to everyday memory problems. We examined whether SOC usage varied by age and level of constraints, and if the relationship between resources and memory problems was mitigated by SOC usage. A daily diary paradigm was used to explore day-to-day fluctuations in these relationships. Participants (n=145, ages 22 to 94) completed a baseline interview and a daily diary for seven consecutive days. Multilevel models examined between- and within-person relationships between daily SOC use, daily stressors, cognitive resources, and everyday memory problems. Middle-aged adults had the highest SOC usage, although older adults also showed high SOC use if they had high cognitive resources. More SOC strategies were used on high stress compared to low stress days. Moreover, the relationship between daily stress and memory problems was buffered by daily SOC use, such that on high-stress days, those who used more SOC strategies reported fewer memory problems than participants who used fewer SOC strategies. The paradox of resources and SOC use can be qualified by the type of resource-limitation. Deficits in global resources were not tied to SOC usage or benefits. Conversely, under daily constraints tied to stress, the use of SOC increased and led to fewer memory problems. PMID:26997686

  19. Effect of gamma irradiation on phenol content, antioxidant activity and biological activity of black maca and red maca extracts (Lepidium meyenii walp).

    PubMed

    Zevallos-Concha, A; Nuñez, D; Gasco, M; Vasquez, C; Quispe, M; Gonzales, G F

    2016-01-01

    This study was performed to determine the effects of gamma irradiation on UV spectrum on maca, total content of polyphenols, 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging activities and in vivo biological activities of red and black maca extracts (Lepidium meyenii). Adult mice of the strain Swiss aged 3 months and weighing 30-35 g in average were used to determine biological activities. Daily sperm production, effect on testosterone-induced prostate hyperplasia and forced swimming test were used to determine the effect of irradiation on biological activities of maca extracts. Irradiation did not show differences in UV spectrum but improves the amount of total polyphenols in red maca as well as in black maca extracts. In both cases, black maca extract has more content of polyphenols than red maca extract (p < 0.01). Gamma irradiation significantly increased the antioxidant capacity (p < 0.05). No difference was observed in daily sperm production when irradiated and nonirradiated maca extract were administered to mice (p > 0.05). Black maca extract but not red maca extract has more swimming endurance capacity in the forced swimming test. Irradiation of black maca extract increased the swimming time to exhaustion (p < 0.05). This is not observed with red maca extract (p > 0.05). Testosterone enanthate (TE) increased significantly the ventral prostate weight. Administration of red maca extract in animals treated with TE prevented the increase in prostate weight. Irradiation did not modify effect of red maca extract on prostate weight (p > 0.05). In conclusion, irradiation does not alter the biological activities of both black maca and red maca extracts. It prevents the presence of microorganisms in the extracts of black or red maca, but the biological activities were maintained.

  20. The Impacts of Daily Surface Forcing in the Upper Ocean over Tropical Pacific: A Numerical Study

    NASA Technical Reports Server (NTRS)

    Sui, C.-H.; Rienecker, Michele M.; Li, Xiaofan; Lau, William K.-M.; Laszlo, Istvan; Pinker, Rachel T.

    2001-01-01

    Tropical Pacific Ocean is an important region that affects global climate. How the ocean responds to the atmospheric surface forcing (surface radiative, heat and momentum fluxes) is a major topic in oceanographic research community. The ocean becomes warm when more heat flux puts into the ocean. The monthly mean forcing has been used in the past years since daily forcing was unavailable due to the lack of observations. The daily forcing is now available from the satellite measurements. This study investigates the response of the upper ocean over tropical Pacific to the daily atmospheric surface forcing. The ocean surface heat budgets are calculated to determine the important processes for the oceanic response. The differences of oceanic responses between the eastern and western Pacific are intensively discussed.

  1. The TROPOMI surface UV algorithm

    NASA Astrophysics Data System (ADS)

    Lindfors, Anders V.; Kujanpää, Jukka; Kalakoski, Niilo; Heikkilä, Anu; Lakkala, Kaisa; Mielonen, Tero; Sneep, Maarten; Krotkov, Nickolay A.; Arola, Antti; Tamminen, Johanna

    2018-02-01

    The TROPOspheric Monitoring Instrument (TROPOMI) is the only payload of the Sentinel-5 Precursor (S5P), which is a polar-orbiting satellite mission of the European Space Agency (ESA). TROPOMI is a nadir-viewing spectrometer measuring in the ultraviolet, visible, near-infrared, and the shortwave infrared that provides near-global daily coverage. Among other things, TROPOMI measurements will be used for calculating the UV radiation reaching the Earth's surface. Thus, the TROPOMI surface UV product will contribute to the monitoring of UV radiation by providing daily information on the prevailing UV conditions over the globe. The TROPOMI UV algorithm builds on the heritage of the Ozone Monitoring Instrument (OMI) and the Satellite Application Facility for Atmospheric Composition and UV Radiation (AC SAF) algorithms. This paper provides a description of the algorithm that will be used for estimating surface UV radiation from TROPOMI observations. The TROPOMI surface UV product includes the following UV quantities: the UV irradiance at 305, 310, 324, and 380 nm; the erythemally weighted UV; and the vitamin-D weighted UV. Each of these are available as (i) daily dose or daily accumulated irradiance, (ii) overpass dose rate or irradiance, and (iii) local noon dose rate or irradiance. In addition, all quantities are available corresponding to actual cloud conditions and as clear-sky values, which otherwise correspond to the same conditions but assume a cloud-free atmosphere. This yields 36 UV parameters altogether. The TROPOMI UV algorithm has been tested using input based on OMI and the Global Ozone Monitoring Experiment-2 (GOME-2) satellite measurements. These preliminary results indicate that the algorithm is functioning according to expectations.

  2. Design principles and field performance of a solar spectral irradiance meter

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Tatsiankou, V.; Hinzer, K.; Haysom, J.

    2016-08-01

    A solar spectral irradiance meter (SSIM), designed for measuring the direct normal irradiance (DNI) in six wavelength bands, has been combined with models to determine key atmospheric transmittances and the resulting spectral irradiance distribution of DNI under all sky conditions. The design principles of the SSIM, implementation of a parameterized transmittance model, and field performance comparisons of modeled solar spectra with reference radiometer measurements are presented. Two SSIMs were tested and calibrated at the National Renewable Energy Laboratory (NREL) against four spectroradiometers and an absolute cavity radiometer. The SSIMs' DNI was on average within 1% of the DNI values reportedmore » by one of NREL's primary absolute cavity radiometers. An additional SSIM was installed at the SUNLAB Outdoor Test Facility in September 2014, with ongoing collection of environmental and spectral data. The SSIM's performance in Ottawa was compared against a commercial pyrheliometer and a spectroradiometer over an eight month study. The difference in integrated daily spectral irradiance between the SSIM and the ASD spectroradiometer was found to be less than 1%. The cumulative energy density collected by the SSIM over this duration agreed with that measured by an Eppley model NIP pyrheliometer to within 0.5%. No degradation was observed.« less

  3. Medium range flood forecasts at global scale

    NASA Astrophysics Data System (ADS)

    Voisin, N.; Wood, A. W.; Lettenmaier, D. P.; Wood, E. F.

    2006-12-01

    While weather and climate forecast methods have advanced greatly over the last two decades, this capability has yet to be evidenced in mitigation of water-related natural hazards (primarily floods and droughts), especially in the developing world. Examples abound of extreme property damage and loss of life due to floods in the underdeveloped world. For instance, more than 4.5 million people were affected by the July 2000 flooding of the Mekong River and its tributaries in Cambodia, Vietnam, Laos and Thailand. The February- March 2000 floods in the Limpopo River of Mozambique caused extreme disruption to that country's fledgling economy. Mitigation of these events through advance warning has typically been modest at best. Despite the above noted improvement in weather and climate forecasts, there is at present no system for forecasting of floods globally, notwithstanding that the potential clearly exists. We describe a methodology that is eventually intended to generate global flood predictions routinely. It draws heavily from the experimental North American Land Data Assimilation System (NLDAS) and the companion Global Land Data Assimilation System (GLDAS) for development of nowcasts, and the University of Washington Experimental Hydrologic Prediction System to develop ensemble hydrologic forecasts based on Numerical Weather Prediction (NWP) models which serve both as nowcasts (and hence reduce the need for in situ precipitation and other observations in parts of the world where surface networks are critically deficient) and provide forecasts for lead times as long as fifteen days. The heart of the hydrologic modeling system is the University of Washington/Princeton University Variable Infiltration Capacity (VIC) macroscale hydrology model. In the prototype (tested using retrospective data), VIC is driven globally up to the time of forecast with daily ERA40 precipitation (rescaled on a monthly basis to a station-based global climatology), ERA40 wind, and ERA40

  4. CMSAF products Cloud Fraction Coverage and Cloud Type used for solar global irradiance estimation

    NASA Astrophysics Data System (ADS)

    Badescu, Viorel; Dumitrescu, Alexandru

    2016-08-01

    Two products provided by the climate monitoring satellite application facility (CMSAF) are the instantaneous Cloud Fractional Coverage (iCFC) and the instantaneous Cloud Type (iCTY) products. Previous studies based on the iCFC product show that the simple solar radiation models belonging to the cloudiness index class n CFC = 0.1-1.0 have rRMSE values ranging between 68 and 71 %. The products iCFC and iCTY are used here to develop simple models providing hourly estimates for solar global irradiance. Measurements performed at five weather stations of Romania (South-Eastern Europe) are used. Two three-class characterizations of the state-of-the-sky, based on the iCTY product, are defined. In case of the first new sky state classification, which is roughly related with cloud altitude, the solar radiation models proposed here perform worst for the iCTY class 4-15, with rRMSE values ranging between 46 and 57 %. The spreading error of the simple models is lower than that of the MAGIC model for the iCTY classes 1-4 and 15-19, but larger for iCTY classes 4-15. In case of the second new sky state classification, which takes into account in a weighted manner the chance for the sun to be covered by different types of clouds, the solar radiation models proposed here perform worst for the cloudiness index class n CTY = 0.7-0.1, with rRMSE values ranging between 51 and 66 %. Therefore, the two new sky state classifications based on the iCTY product are useful in increasing the accuracy of solar radiation models.

  5. Relationships Among Nightly Sleep Quality, Daily Stress, and Daily Affect.

    PubMed

    Blaxton, Jessica M; Bergeman, Cindy S; Whitehead, Brenda R; Braun, Marcia E; Payne, Jessic D

    2017-05-01

    We explored the prospective, microlevel relationship between nightly sleep quality (SQ) and the subsequent day's stress on positive (PA) and negative affect (NA) as well as the moderating relationships between nightly SQ, subsequent stress, and subsequent PA on NA. We investigated whether age moderated these relationships. We collected 56 days of sleep, stress, and affect data using daily diary questionnaires (N = 552). We used multilevel modeling to assess relationships at the between- and within-person levels. Daily increases in SQ and decreases in stress interacted to predict higher daily PA and lower daily NA. Better SQ in older adults enhanced the benefits of PA on the stress-NA relationship more during times of low stress, whereas better sleep in younger adults enhanced the benefits of PA more during times of high stress. Between-person effects were stronger predictors of well-being outcomes than within-person variability. The combination of good SQ and higher PA buffered the impact of stress on NA. The moderating impact of age suggests that sleep and stress play different roles across adulthood. Targeting intervention and prevention strategies to improve SQ and enhance PA could disrupt the detrimental relationship between daily stress and NA. © The Author 2015. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  6. Modelling daily PM2.5 concentrations at high spatio-temporal resolution across Switzerland.

    PubMed

    de Hoogh, Kees; Héritier, Harris; Stafoggia, Massimo; Künzli, Nino; Kloog, Itai

    2018-02-01

    Spatiotemporal resolved models were developed predicting daily fine particulate matter (PM 2.5 ) concentrations across Switzerland from 2003 to 2013. Relatively sparse PM 2.5 monitoring data was supplemented by imputing PM 2.5 concentrations at PM 10 sites, using PM 2.5 /PM 10 ratios at co-located sites. Daily PM 2.5 concentrations were first estimated at a 1 × 1km resolution across Switzerland, using Multiangle Implementation of Atmospheric Correction (MAIAC) spectral aerosol optical depth (AOD) data in combination with spatiotemporal predictor data in a four stage approach. Mixed effect models (1) were used to predict PM 2.5 in cells with AOD but without PM 2.5 measurements (2). A generalized additive mixed model with spatial smoothing was applied to generate grid cell predictions for those grid cells where AOD was missing (3). Finally, local PM 2.5 predictions were estimated at each monitoring site by regressing the residuals from the 1 × 1km estimate against local spatial and temporal variables using machine learning techniques (4) and adding them to the stage 3 global estimates. The global (1 km) and local (100 m) models explained on average 73% of the total,71% of the spatial and 75% of the temporal variation (all cross validated) globally and on average 89% (total) 95% (spatial) and 88% (temporal) of the variation locally in measured PM 2.5 concentrations. Copyright © 2017 Elsevier Ltd. All rights reserved.

  7. External Beam Accelerated Partial-Breast Irradiation Using 32 Gy in 8 Twice-Daily Fractions: 5-Year Results of a Prospective Study

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Pashtan, Itai M.; Recht, Abram; Ancukiewicz, Marek

    Purpose: External beam accelerated partial breast irradiation (APBI) is an increasingly popular technique for treatment of patients with early stage breast cancer following breast-conserving surgery. Here we present 5-year results of a prospective trial. Methods and Materials: From October 2003 through November 2005, 98 evaluable patients with stage I breast cancer were enrolled in the first dose step (32 Gy delivered in 8 twice-daily fractions) of a prospective, multi-institutional, dose escalation clinical trial of 3-dimensional conformal external beam APBI (3D-APBI). Median age was 61 years; median tumor size was 0.8 cm; 89% of tumors were estrogen receptor positive; 10% hadmore » a triple-negative phenotype; and 1% had a HER-2-positive subtype. Median follow-up was 71 months (range, 2-88 months; interquartile range, 64-75 months). Results: Five patients developed ipsilateral breast tumor recurrence (IBTR), for a 5-year actuarial IBTR rate of 5% (95% confidence interval [CI], 1%-10%). Three of these cases occurred in patients with triple-negative disease and 2 in non-triple-negative patients, for 5-year actuarial IBTR rates of 33% (95% CI, 0%-57%) and 2% (95% CI, 0%-6%; P<.0001), respectively. On multivariable analysis, triple-negative phenotype was the only predictor of IBTR, with borderline statistical significance after adjusting for tumor grade (P=.0537). Conclusions: Overall outcomes were excellent, particularly for patients with estrogen receptor-positive disease. Patients in this study with triple-negative breast cancer had a significantly higher IBTR rate than patients with other receptor phenotypes when treated with 3D-APBI. Larger, prospective 3D-APBI clinical trials should continue to evaluate the effect of hormone receptor phenotype on IBTR rates.« less

  8. External beam accelerated partial-breast irradiation using 32 gy in 8 twice-daily fractions: 5-year results of a prospective study.

    PubMed

    Pashtan, Itai M; Recht, Abram; Ancukiewicz, Marek; Brachtel, Elena; Abi-Raad, Rita F; D'Alessandro, Helen A; Levy, Antonin; Wo, Jennifer Y; Hirsch, Ariel E; Kachnic, Lisa A; Goldberg, Saveli; Specht, Michelle; Gadd, Michelle; Smith, Barbara L; Powell, Simon N; Taghian, Alphonse G

    2012-11-01

    External beam accelerated partial breast irradiation (APBI) is an increasingly popular technique for treatment of patients with early stage breast cancer following breast-conserving surgery. Here we present 5-year results of a prospective trial. From October 2003 through November 2005, 98 evaluable patients with stage I breast cancer were enrolled in the first dose step (32 Gy delivered in 8 twice-daily fractions) of a prospective, multi-institutional, dose escalation clinical trial of 3-dimensional conformal external beam APBI (3D-APBI). Median age was 61 years; median tumor size was 0.8 cm; 89% of tumors were estrogen receptor positive; 10% had a triple-negative phenotype; and 1% had a HER-2-positive subtype. Median follow-up was 71 months (range, 2-88 months; interquartile range, 64-75 months). Five patients developed ipsilateral breast tumor recurrence (IBTR), for a 5-year actuarial IBTR rate of 5% (95% confidence interval [CI], 1%-10%). Three of these cases occurred in patients with triple-negative disease and 2 in non-triple-negative patients, for 5-year actuarial IBTR rates of 33% (95% CI, 0%-57%) and 2% (95% CI, 0%-6%; P<.0001), respectively. On multivariable analysis, triple-negative phenotype was the only predictor of IBTR, with borderline statistical significance after adjusting for tumor grade (P=.0537). Overall outcomes were excellent, particularly for patients with estrogen receptor-positive disease. Patients in this study with triple-negative breast cancer had a significantly higher IBTR rate than patients with other receptor phenotypes when treated with 3D-APBI. Larger, prospective 3D-APBI clinical trials should continue to evaluate the effect of hormone receptor phenotype on IBTR rates. Copyright © 2012 Elsevier Inc. All rights reserved.

  9. Trends and variability of daily temperature extremes during 1960-2012 in the Yangtze River Basin, China

    USDA-ARS?s Scientific Manuscript database

    The variability of temperature extremes has been the focus of attention during the past few decades, and may exert a great influence on the global hydrologic cycle and energy balance through thermal forcing. Based on daily minimum and maximum temperature observed by the China Meteorological Administ...

  10. Magnitude and variability of land evaporation and its components at the global scale

    USDA-ARS?s Scientific Manuscript database

    A physics-based methodology is applied to estimate global land-surface evaporation from multi-satellite observations. GLEAM (Global Land-surface Evaporation: the Amsterdam Methodology) combines a wide range of remotely sensed observations within a Priestley and Taylor-based framework. Daily actual e...

  11. Global geodesy using GPS without fiducial sites

    NASA Technical Reports Server (NTRS)

    Heflin, Michael; Bertiger, Willy; Blewitt, Geoff; Freedman, Adam; Hurst, Ken; Lichten, Steve; Lindqwister, Ulf; Vigue, Yvonne; Webb, Frank; Yunck, Tom

    1992-01-01

    Baseline lengths and geocentric radii have been determined from GPS data without the use of fiducial sites. Data from the first GPS experiment for the IERS and Geodynamics (GIG '91) have been analyzed with a no-fiducial strategy. A baseline length daily repeatability of 2 mm + 4 parts per billion was obtained for baselines in the Northern Hemisphere. Comparison of baseline lengths from GPS and the global VLBI solution GLB659 (Caprette et al. 1990) show rms agreement of 2.1 parts per billion. The geocentric radius mean daily repeatability for all sites was 15 cm. Comparison of geocentric radii from GPS and SV5 (Murray et al. 1990) show rms agreement of 3.8 cm. Given n globally distributed stations, the n(n - 1)/2 baseline lengths and n geocentric radii uniquely define a rigid closed polyhedron with a well-defined center of mass. Geodetic information can be obtained by examining the structure of the polyhedron and its change with time.

  12. Adolescent Daily and General Maladjustment: Is There Reactivity to Daily Repeated Measures Methodologies?

    ERIC Educational Resources Information Center

    Nishina, Adrienne

    2012-01-01

    The present study examined whether repeated exposure to daily surveys about negative social experiences predicts changes in adolescents' daily and general maladjustment, and whether question content moderates these changes. Across a 2-week period, 6th-grade students (N = 215; mode age = 11) completed 5 daily reports tapping experienced or…

  13. A grid for a precise analysis of daily activities.

    PubMed

    Wojtasik, V; Olivier, C; Lekeu, F; Quittre, A; Adam, S; Salmon, E

    2010-01-01

    Assessment of daily living activities is essential in patients with Alzheimer's disease. Most current tools quantitatively assess overall ability but provide little qualitative information on individual difficulties. Only a few tools allow therapists to evaluate stereotyped activities and record different types of errors. We capitalised on the Kitchen Activity Assessment to design a widely applicable analysis grid that provides both qualitative and quantitative data on activity performance. A cooking activity was videotaped in 15 patients with dementia and assessed according to the different steps in the execution of the task. The evaluations obtained with our grid showed good correlations between raters, between versions of the grid and between sessions. Moreover, the degree of independence obtained with our analysis of the task correlated with the Kitchen Activity Assessment score and with a global score of cognitive functioning. We conclude that assessment of a daily living activity with this analysis grid is reproducible and relatively independent of the therapist, and thus provides quantitative and qualitative information useful for both evaluating and caring for demented patients.

  14. Combining Radar and Daily Precipitation Data to Estimate Meaningful Sub-daily Precipitation Extremes

    NASA Astrophysics Data System (ADS)

    Pegram, G. G. S.; Bardossy, A.

    2016-12-01

    Short duration extreme rainfalls are important for design. The purpose of this presentation is not to improve the day by day estimation of precipitation, but to obtain reasonable statistics for the subdaily extremes at gauge locations. We are interested specifically in daily and sub-daily extreme values of precipitation at gauge locations. We do not employ the common procedure of using time series of control station to determine the missing data values in a target. We are interested in individual rare events, not sequences. The idea is to use radar to disaggregate daily totals to sub-daily amounts. In South Arica, an S-band radar operated relatively continuously at Bethlehem from 1998 to 2003, whose scan at 1.5 km above ground [CAPPI] overlapped a dense (10 km spacing) set of 45 pluviometers recording in the same 6-year period. Using this valuable set of data, we are only interested in rare extremes, therefore small to medium values of rainfall depth were neglected, leaving 12 days of ranked daily maxima in each set per year, whose sum typically comprised about 50% of each annual rainfall total. The method presented here uses radar for disaggregating daily gauge totals in subdaily intervals down to 15 minutes in order to extract the maxima of sub-hourly through to daily rainfall at each of 37 selected radar pixels [1 km square in plan] which contained one of the 45 pluviometers not masked out by the radar foot-print. The pluviometer data were aggregated to daily totals, to act as if they were daily read gauges; their only other task was to help in the cross-validation exercise. The extrema were obtained as quantiles by ordering the 12 daily maxima of each interval per year. The unusual and novel goal was not to obtain the reproduction of the precipitation matching in space and time, but to obtain frequency distributions of the gauge and radar extremes, by matching their ranks, which we found to be stable and meaningful in cross-validation tests. We provide and

  15. Evaluation and intercomparison of GPM-IMERG and TRMM 3B42 daily precipitation products over Greece

    NASA Astrophysics Data System (ADS)

    Kazamias, A. P.; Sapountzis, M.; Lagouvardos, K.

    2017-09-01

    Accurate precipitation data at high temporal and spatial resolutions are needed for numerous applications in hydrology, water resources management and flood risk management. Satellite-based precipitation estimations/products offer a potential alternative source of rainfall data for regions with sparse rain gauge network. The recently launched Global Precipitation Measurement (GPM) mission is the successor of Tropical Rainfall Measuring Mission (TRMM) providing global precipitation estimates at spatial resolution of 0.1 degree x 0.1 degree and half-hourly temporal resolution. This study aims at evaluating the accuracy of the Integrated Multi-satellite Retrievals for GPM (IMERG) near-real-time daily product (GPM-3IMERGDL) against rain gauge observations from a network of stations distributed across Greece for the year 2016. Moreover, the GPM-IMERG product is also compared with its predecessor, the Version-7 near-real-time (3B42RT) daily product of TRMM Multisatellite Precipitation Analysis (TMPA). Several statistical metrics are used to quantitatively evaluate the performance of the satellite-based precipitation estimates against rain gauge observations. In addition, categorical statistical indices are used to assess rain detection capabilities of the two satellite products. The GPM-IMERG daily product shows reasonable agreement (CC=0.60) against rain gauge observations, with the exception of coastal areas in which low correlations are achieved. The GPM-IMERG daily precipitation product tends to overestimate rainfall, especially in complex terrain areas with high annual precipitation. In particular, rainfall estimates in western Greece have a strong positive bias. On the other hand, the TRMM 3B42 product shows low correlation (CC=0.45) against rain gauge observations and slightly underestimates rainfall. This study is a first attempt to evaluate and compare the newly introduced GPM-IMERG and the TRMM 3B42 rainfall products at daily timescale over Greece.

  16. The Ultraviolet Total Ozone Unit (TOU) IN-ORBIT PERFORMANCE AND CALIBRATION

    NASA Astrophysics Data System (ADS)

    Wang, Yongmei; Fu, Liping; Zhang, Zhongmou

    The Ultraviolet Total Ozone Unit (TOU) was launched on 27 May 2008 on FY-3 meteorological satellite. The main purpose of TOU is to measure the incident solar radiation and backscattered ultraviolet radiance for retrieving daily global map of atmospheric ozone. TOU is a fixed grating and slit-array Ebert-Fastie grating spectrograph system. It has the multi-wavelengths detecting and two-dimensional scanning which enables global daily ground coverage. This paper discusses the recent working status of the instrument, including the sensitivity, measuring precision of solar irradiance, diffuser degradation and wavelength drift, and then presents the in-flight calibration and performance results.

  17. Factors influencing quit attempts among male daily smokers in China✩

    PubMed Central

    Zhao, Luhua; Song, Yang; Xiao, Lin; Palipudi, Krishna; Asma, Samira

    2015-01-01

    Background China has the largest population of smokers in the world, yet the quit rate is low. We used data from the 2010 Global Adult Tobacco Survey China to identify factors influencing quit attempts among male Chinese daily smokers. Methods The study sample included 3303 male daily smokers. To determine the factors that were significantly associated with making a quit attempt, we conducted logistic regression analyses. In addition, mediation anal yses were carried out to investigate how the intermediate association among demographics (age, education, urbanicity) and smoking related variables affected making a quit attempt. Results An estimated 11.0% of male daily smokers tried to quit smoking in the 12 months prior to the survey. Logistic regression analysis indicated that younger age (15–24 years), being advised to quit by a health care provider (HCP) in the past 12 months, lower cigarette cost per pack, monthly or less frequent exposure to smoking at home, and awareness of the harms of tobacco use were significantly associated with making a quit attempt. Additional mediation analyses showed that having knowledge of the harm of tobacco, exposure to smoking at home, and having been advised to quit by an HCP were mediators of making a quit attempt for other independent variables. Conclusion Evidence-based tobacco control measures such as conducting educational campaigns on the harms of tobacco use, establishing smoke-free policies at home, and integrating tobacco cessation advice into primary health care services can increase quit attempts and reduce smoking among male Chinese daily smokers. PMID:26441296

  18. Factors influencing quit attempts among male daily smokers in China.

    PubMed

    Zhao, Luhua; Song, Yang; Xiao, Lin; Palipudi, Krishna; Asma, Samira

    2015-12-01

    China has the largest population of smokers in the world, yet the quit rate is low. We used data from the 2010 Global Adult Tobacco Survey China to identify factors influencing quit attempts among male Chinese daily smokers. The study sample included 3303 male daily smokers. To determine the factors that were significantly associated with making a quit attempt, we conducted logistic regression analyses. In addition, mediation analyses were carried out to investigate how the intermediate association among demographics (age, education, urbanicity) and smoking-related variables affected making a quit attempt. An estimated 11.0% of male daily smokers tried to quit smoking in the 12 months prior to the survey. Logistic regression analysis indicated that younger age (15-24 years), being advised to quit by a health care provider (HCP) in the past 12 months, lower cigarette cost per pack, monthly or less frequent exposure to smoking at home, and awareness of the harms of tobacco use were significantly associated with making a quit attempt. Additional mediation analyses showed that having knowledge of the harm of tobacco, exposure to smoking at home, and having been advised to quit by an HCP were mediators of making a quit attempt for other independent variables. Evidence-based tobacco control measures such as conducting educational campaigns on the harms of tobacco use, establishing smoke-free policies at home, and integrating tobacco cessation advice into primary health care services can increase quit attempts and reduce smoking among male Chinese daily smokers. Copyright © 2015 Elsevier Inc. All rights reserved.

  19. Mesalamine once daily is more effective than twice daily in patients with quiescent ulcerative colitis.

    PubMed

    Dignass, Axel U; Bokemeyer, Bernd; Adamek, Henning; Mross, Michael; Vinter-Jensen, Lars; Börner, Norbert; Silvennoinen, Jouni; Tan, Gie; Pool, Marco Oudkerk; Stijnen, Theo; Dietel, Peter; Klugmann, Tobias; Vermeire, Severine; Bhatt, Aomesh; Veerman, Henri

    2009-07-01

    Oral mesalamine (5-aminosalicylate) is the current standard of care for mild-to-moderate ulcerative colitis. We investigated the efficacy and safety of once daily administration of prolonged-release mesalamine granules in maintenance of remission in patients with quiescent ulcerative colitis, compared with the well established twice daily dosing regimen. In this multicenter, randomized, single blind, noninferiority trial, 362 patients with quiescent ulcerative colitis were randomly assigned (1:1) to groups that were given oral mesalamine 2 g, once daily, or 1 g, twice daily, for 12 months. The primary objective was to compare remission rates at 1 year, based on the ulcerative colitis disease activity index score, using Kaplan-Meier methodology. At 1 year, 70.9% of the group given 2 g mesalamine once daily remained in remission vs 58.9% of the group given 1 g mesalamine twice daily; this difference was statistically significant (P = .024), indicating the increased efficacy of once daily, compared with twice daily, dosing. Self-reported adherence to therapy, measured by visual analog scale score after 4, 8, and 12 months, was significantly greater in the group given 2 g mesalamine once daily, compared with twice daily, at all but 1 study visit (P < .05). Compliance measured by medication taken was not significantly different between the groups. The difference between the 2 groups in overall incidence of adverse events was not statistically significant (P = .23). Patients with ulcerative colitis given prolonged-release oral mesalamine 2 g once daily had better remission rates, acceptability, and self-reported adherence to therapy compared with patients given oral mesalamine 1 g twice daily.

  20. Climate-induced variations in global wildfire danger from 1979 to 2013

    Treesearch

    W. Matt Jolly; Mark A. Cochrane; Patrick H. Freeborn; Zachary A. Holden; Timothy J. Brown; Grant J. Williamson; David M. J. S. Bowman

    2015-01-01

    Climate strongly influences global wildfire activity, and recent wildfire surges may signal fire weather-induced pyrogeographic shifts. Here we use three daily global climate data sets and three fire danger indices to develop a simple annual metric of fire weather season length, and map spatio-temporal trends from 1979 to 2013. We show that fire weather seasons have...

  1. Ameliorative effect of black grape juice on systemic alterations and mandibular osteoradionecrosis induced by whole brain irradiation in rats.

    PubMed

    Freitas, Robson B; González, Paquita; Martins, Nara Maria B; Andrade, Edson R; Cesteros Morante, María Jesús; Conles Picos, Iban; Costilla García, Serafín; Bauermann, Liliane F; Barrio, Juan Pablo

    2017-02-01

    Whole brain irradiation (WBI) causes a variety of secondary side-effects including anorexia and bone necrosis. We evaluated the radiomodifying effect of black grape juice (BGJ) on WBI alterations in rats measuring food and water intake, body weight, hemogram, and morphological and histological mandibular parameters. Forty male rats (200-250 g) were exposed to eight sessions of cranial X-ray irradiation. The total dose absorbed was 32 Gy delivered over 2 weeks. Four groups were defined: (i) NG: non-irradiated, glucose and fructose solution-supplemented (GFS); (ii) NJ: non-irradiated, BGJ-supplemented; (iii) RG: irradiated, GFS-supplemented; and (iv) RJ: irradiated, BGJ-supplemented. Rats received daily BGJ or GFS dosing by gavage starting 4 days before, continuing during, and ending 4 days after WBI. RJ rats ingested more food and water and showed less body weight loss than RG rats during the irradiation period. Forty days after WBI, irradiated animals started losing weight again compared with controls as a consequence of masticatory hypofunction by mandibular osteoradionecrosis (ORN). Osteoclastic activity and inflammation were apparent in RG rat mandibles. BGJ was able to attenuate the severity of ORN as well as to improve white and red blood cell counts. Fractionated whole brain irradiation induces mandibular changes that interfere with normal feeding. BGJ can be used to mitigate systemic side-effects of brain irradiation and ORN.

  2. Optimizing UV Index determination from broadband irradiances

    NASA Astrophysics Data System (ADS)

    Tereszchuk, Keith A.; Rochon, Yves J.; McLinden, Chris A.; Vaillancourt, Paul A.

    2018-03-01

    A study was undertaken to improve upon the prognosticative capability of Environment and Climate Change Canada's (ECCC) UV Index forecast model. An aspect of that work, and the topic of this communication, was to investigate the use of the four UV broadband surface irradiance fields generated by ECCC's Global Environmental Multiscale (GEM) numerical prediction model to determine the UV Index. The basis of the investigation involves the creation of a suite of routines which employ high-spectral-resolution radiative transfer code developed to calculate UV Index fields from GEM forecasts. These routines employ a modified version of the Cloud-J v7.4 radiative transfer model, which integrates GEM output to produce high-spectral-resolution surface irradiance fields. The output generated using the high-resolution radiative transfer code served to verify and calibrate GEM broadband surface irradiances under clear-sky conditions and their use in providing the UV Index. A subsequent comparison of irradiances and UV Index under cloudy conditions was also performed. Linear correlation agreement of surface irradiances from the two models for each of the two higher UV bands covering 310.70-330.0 and 330.03-400.00 nm is typically greater than 95 % for clear-sky conditions with associated root-mean-square relative errors of 6.4 and 4.0 %. However, underestimations of clear-sky GEM irradiances were found on the order of ˜ 30-50 % for the 294.12-310.70 nm band and by a factor of ˜ 30 for the 280.11-294.12 nm band. This underestimation can be significant for UV Index determination but would not impact weather forecasting. Corresponding empirical adjustments were applied to the broadband irradiances now giving a correlation coefficient of unity. From these, a least-squares fitting was derived for the calculation of the UV Index. The resultant differences in UV indices from the high-spectral-resolution irradiances and the resultant GEM broadband irradiances are typically within 0

  3. Progress Towards Deriving an Improved Long-Term Global Solar Resource

    NASA Technical Reports Server (NTRS)

    Cox, Stephen J.; Mikovitz, J. Colleen; Zhang, Taiping; Sorlie, Susan; Stackhouse, Paul W., Jr.; Perez, Richard; Hemker, Karl, Jr.; Schlemmer, James; Kivalov, Sergey; Renne, David; hide

    2013-01-01

    This paper describes an ongoing project to provide the National Renewable Energy Laboratory (NREL) with a global long-term advanced global solar mapping production system for improved depiction of historical solar resources and to provide a mechanism for continual updates. This new production system is made possible by the efforts of NASA and NOAA to completely reprocess the International Satellite Cloud Climatology Project (ISCCP) data set that provides satellite visible and infrared radiances together with retrieved cloud and surface properties on a 10 km, 3-hourly basis beginning July 1983. We provide a general overview of this project, samples of the new solar irradiance mapped data products, and comparisons to surface measurements. Samples of the use of the SUNY-Albany solar irradiance algorithm applied to the ISCCP data show very good agreement with high quality surface measurements. We identify the next steps in the production of the data set.

  4. Total daily physical activity and the risk of AD and cognitive decline in older adults

    PubMed Central

    Boyle, P.A.; Yu, L.; Shah, R.C.; Wilson, R.S.; Bennett, D.A.

    2012-01-01

    Objective: Studies examining the link between objective measures of total daily physical activity and incident Alzheimer disease (AD) are lacking. We tested the hypothesis that an objective measure of total daily physical activity predicts incident AD and cognitive decline. Methods: Total daily exercise and nonexercise physical activity was measured continuously for up to 10 days with actigraphy (Actical®; Philips Healthcare, Bend, OR) from 716 older individuals without dementia participating in the Rush Memory and Aging Project, a prospective, observational cohort study. All participants underwent structured annual clinical examination including a battery of 19 cognitive tests. Results: During an average follow-up of about 4 years, 71 subjects developed clinical AD. In a Cox proportional hazards model adjusting for age, sex, and education, total daily physical activity was associated with incident AD (hazard ratio = 0.477; 95% confidence interval 0.273–0.832). The association remained after adjusting for self-report physical, social, and cognitive activities, as well as current level of motor function, depressive symptoms, chronic health conditions, and APOE allele status. In a linear mixed-effect model, the level of total daily physical activity was associated with the rate of global cognitive decline (estimate 0.033, SE 0.012, p = 0.007). Conclusions: A higher level of total daily physical activity is associated with a reduced risk of AD. PMID:22517108

  5. Total daily physical activity and the risk of AD and cognitive decline in older adults.

    PubMed

    Buchman, A S; Boyle, P A; Yu, L; Shah, R C; Wilson, R S; Bennett, D A

    2012-04-24

    Studies examining the link between objective measures of total daily physical activity and incident Alzheimer disease (AD) are lacking. We tested the hypothesis that an objective measure of total daily physical activity predicts incident AD and cognitive decline. Total daily exercise and nonexercise physical activity was measured continuously for up to 10 days with actigraphy (Actical®; Philips Healthcare, Bend, OR) from 716 older individuals without dementia participating in the Rush Memory and Aging Project, a prospective, observational cohort study. All participants underwent structured annual clinical examination including a battery of 19 cognitive tests. During an average follow-up of about 4 years, 71 subjects developed clinical AD. In a Cox proportional hazards model adjusting for age, sex, and education, total daily physical activity was associated with incident AD (hazard ratio = 0.477; 95% confidence interval 0.273-0.832). The association remained after adjusting for self-report physical, social, and cognitive activities, as well as current level of motor function, depressive symptoms, chronic health conditions, and APOE allele status. In a linear mixed-effect model, the level of total daily physical activity was associated with the rate of global cognitive decline (estimate 0.033, SE 0.012, p = 0.007). A higher level of total daily physical activity is associated with a reduced risk of AD.

  6. Drawbacks of proactivity: Effects of daily proactivity on daily salivary cortisol and subjective well-being.

    PubMed

    Fay, Doris; Hüttges, Annett

    2017-10-01

    The benefit of proactive work behaviors for performance-related outcomes has been well established. However, this approach to studying proactivity has not yet acknowledged its potential implications for the actor's well-being. Drawing on the fact that resources at work are limited and that the workplace is a social system characterized by interdependencies, we proposed that daily proactivity could have a negative effect on daily well-being. We furthermore proposed that this effect should be mediated by work overload and negative affect. We conducted a daily diary study (N = 72) to test the potential negative effects of proactivity on daily well-being. Data was collected across 3 consecutive work days. During several daily measurement occasions, participants reported proactivity, work overload, negative affect, and fatigue. They also provided 4 saliva samples per day, from which cortisol was assayed. Based on the 4 samples, a measure of daily cortisol output was produced. Multilevel analyses showed that daily proactivity was positively associated with higher daily cortisol output. The positive association of daily proactivity with bedtime fatigue was marginally significant. There was no support for a mediating effect of work overload and negative affect. Implications for theory-building on the proactivity-well-being link are discussed. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  7. Associations among daily stressors and salivary cortisol: findings from the National Study of Daily Experiences.

    PubMed

    Stawski, Robert S; Cichy, Kelly E; Piazza, Jennifer R; Almeida, David M

    2013-11-01

    While much research has focused on linking stressful experiences to emotional and biological reactions in laboratory settings, there is an emerging interest in extending these examinations to field studies of daily life. The current study examined day-to-day associations among naturally occurring daily stressors and salivary cortisol in a national sample of adults from the second wave of the National Study of Daily Experiences (NSDE). A sample of 1694 adults (age=57, range=33-84; 44% male) completed telephone interviews detailing their stressors and emotions on eight consecutive evenings. Participants also provided saliva samples upon waking, 30min post-waking, before lunch and before bed, on four consecutive interview days resulting in 5995 days of interview/cortisol data. Analyses revealed three main findings. First, cortisol AUC was significantly higher on stressor days compared to stressor-free days, particularly for arguments and overloads at home, suggesting that daily stressors are associated with increased cortisol output, but that not all daily stressors have such an influence. Second, individuals reporting a greater frequency of stressor days also exhibited a steeper diurnal cortisol slope. Finally, daily stressor-cortisol associations were unaltered after adjustment for daily negative affect and physical symptoms. Our discussion focuses on the influence of naturally occurring daily stressors on daily cortisol and the role of daily diary approaches for studying healthy cortisol responses to psychosocial stressors outside of traditional laboratory settings. Copyright © 2013 Elsevier Ltd. All rights reserved.

  8. Associations among Daily Stressors and Salivary Cortisol: Findings from the National Study of Daily Experiences

    PubMed Central

    Stawski, Robert S.; Cichy, Kelly E.; Piazza, Jennifer R.; Almeida, David M.

    2013-01-01

    While much research has focused on linking stressful experiences to emotional and biological reactions in laboratory settings, there is an emerging interest in extending these examinations to field studies of daily life. The current study examined day-to-day associations among naturally-occurring daily stressors and salivary cortisol in a national sample of adults from the second wave of the National Study of Daily Experiences (NSDE). A sample of 1,694 adults (Age=57, Range=33–84; 44% male) completed telephone interviews detailing their stressors and emotions on eight consecutive evenings. Participants also provided saliva samples upon waking, 30 minutes post-waking, before lunch and before bed, on four consecutive interview days resulting in 5,995 days of interview/cortisol data. Analyses revealed three main findings. First, cortisol AUC was significantly higher on stressor days compared to stressor-free days, particularly for arguments and overloads at home, suggesting that daily stressors are associated with increased cortisol output, but that not all daily stressors have such an influence. Second, individuals reporting a greater frequency of stressor days also exhibited a steeper diurnal cortisol slope. Finally, daily stressor-cortisol associations were unaltered after adjustment for daily negative affect and physical symptoms. Our discussion focuses on the influence of naturally-occurring daily stressors on daily cortisol and the role of daily diary approaches for studying healthy cortisol responses to psychosocial stressors outside of traditional laboratory settings. PMID:23856186

  9. Building global and diffuse solar radiation series and assessing decadal trends in Girona (NE Iberian Peninsula)

    NASA Astrophysics Data System (ADS)

    Calbó, Josep; González, Josep-Abel; Sanchez-Lorenzo, Arturo

    2017-08-01

    Measurement of solar radiation was initiated in Girona, northeast of the Iberian Peninsula, in the late 1980s. Initially, two pyranometers were installed, one of them equipped with a shadowband for measuring the diffuse component. Two other pyranometers currently exist, both ventilated and one of them shadowed, with a sphere, and a pyrheliometer for measuring direct radiation. Additional instruments for other shortwave and longwave components, clouds, and atmospheric aerosols have been installed in recent years. The station is subject to daily inspection, data are saved at high temporal resolution, and instruments are periodically calibrated, all in accordance with the directions of the Baseline Surface Radiation Network. The present paper describes how the entire series of global solar radiation (1987-2014) and diffuse radiation (1994-2014) were built, including the quality control process. Appropriate corrections to the diffuse component were made when a shadowband was employed to make measurements. Analysis of the series reveals that annual mean global irradiance presents a statistically significant increase of 2.5 W m-2 (1.4 %) decade-1 (1988-2014 period), mainly due to what occurs in summer (5.6 W m-2 decade-1). These results constitute the first assessment of solar radiation trends for the northeastern region of the Iberian Peninsula and are consistent with trends observed in the regional surroundings and also by satellite platforms, in agreement with the global brightening phenomenon. Diffuse radiation has decreased at -1.3 W m-2 (-2 %) decade-1 (1994-2014 period), which is a further indication of the reduced cloudiness and/or aerosol load causing the changes.

  10. Treatment of streptococcal pharyngitis with once-daily compared with twice-daily amoxicillin: a noninferiority trial.

    PubMed

    Clegg, Herbert W; Ryan, Amy G; Dallas, Steven D; Kaplan, Edward L; Johnson, Dwight R; Norton, H James; Roddey, Oliver F; Martin, Edward S; Swetenburg, Raymond L; Koonce, Elizabeth W; Felkner, Mary M; Giftos, P Michael

    2006-09-01

    Two relatively small previous studies comparing once-daily amoxicillin with conventional therapy for group A streptococcal (GAS) pharyngitis reported similar rates of bacteriologic success for each treatment group. The purpose of this study was to further evaluate once-daily amoxicillin for GAS pharyngitis in a larger study. In a single pediatric practice, from October through May for 2 consecutive years (2001-2003), we recruited children 3 to 18 years of age who had symptoms and signs suggestive of GAS pharyngitis. Patients with a positive rapid test for GAS were stratified by weight (<40 kg or >or=40 kg) and then randomly assigned to receive once-daily (750 mg or 1000 mg) or twice-daily (2 doses of 375 mg or 500 mg) amoxicillin for 10 days. We determined bacteriologic failure rates for GAS in the pharynx from subsequent swabs taken at 14 to 21 (visit 2) and 28 to 35 (visit 3) days after treatment initiation. We conducted a randomized, controlled, investigator-blinded, noninferiority trial to evaluate whether amoxicillin given once daily would have a bacteriologic failure rate no worse than that of amoxicillin given twice daily within a prespecified margin of 10%. GAS isolates were characterized to distinguish bacteriologic failures from new acquisitions. Adverse events were described and adherence was evaluated by review of returned daily logs and dosage bottles. Of 2139 potential study patients during the 2-year period, we enrolled 652 patients, 326 into each treatment group. Children in the 2 groups were comparable with respect to all demographic and clinical characteristics except that children <40 kg more often presented with rash in each treatment group. At visit 2, failure rates were 20.1% (59 of 294) for the once-daily group and 15.5% (46 of 296) for the twice-daily group (difference, 4.53%; 90% confidence interval [CI], -0.6 to 9.7). At visit 3, failure rates were 2.8% (6 of 216) for the once-daily group and 7.1% (16 of 225) for the twice-daily group

  11. ATF Neutron Irradiation Program Irradiation Vehicle Design Concepts

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Geringer, J. W.; Katoh, Yutai; Howard, Richard H.

    The Japan Atomic Energy Agency (JAEA) under the Civil Nuclear Energy Working Group (CNWG) is engaged in a cooperative research effort with the U.S. Department of Energy (DOE) to explore issues related to nuclear energy, including research on accident-tolerant fuels and materials for use in light water reactors. This work develops a draft technical plan for a neutron irradiation program on the candidate accident-tolerant fuel cladding materials and elements using the High Flux Isotope Reactor (HFIR). The research program requires the design of a detailed experiment, development of test vehicles, irradiation of test specimens, possible post irradiation examination and characterizationmore » of irradiated materials and the shipment of irradiated materials to Japan. This report discusses the conceptual design, the development and irradiation of the test vehicles.« less

  12. Effects of Cell-Free Spleen Extract Treatment on the Hematopoietic Tissues of Irradiated Guinea-Pigs

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ellinger, Friedrigh; Strike, Thomas A.

    2004-07-01

    Guinea pigs were given whole-body Co 60 irradiation (650 r) and injected daily thereafter with cell-free extracts of homologous and heterologous spleen. Spleen of irradiated control guinea pigs showed a progressive reduction of alkaline phosphatase staining commencing after the 3rd postirradiation day and reaching a maximum on or about the 9th day. Treatment of the animals with spleen extracts modified the radioinduced changes in alkaline phosphatase staining, so that an almost normal appearance was noted over the entire 14-day observation period. Most of the alkaiine phosphatase-staining spleen elements were mature neutrophils. It was concluded that spleen extract treatment affects apparentlymore » various celluiar elements of spleen in a different way. The results support the hypothesis that protection of phosphorylization processes against effects of irradiation represent one of the mechanisms by which the radiation protective effect of spleen extracts is effected.« less

  13. Evaluation of solar irradiance models for climate studies

    NASA Astrophysics Data System (ADS)

    Ball, William; Yeo, Kok-Leng; Krivova, Natalie; Solanki, Sami; Unruh, Yvonne; Morrill, Jeff

    2015-04-01

    Instruments on satellites have been observing both Total Solar Irradiance (TSI) and Spectral Solar Irradiance (SSI), mainly in the ultraviolet (UV), since 1978. Models were developed to reproduce the observed variability and to compute the variability at wavelengths that were not observed or had an uncertainty too high to determine an accurate rotational or solar cycle variability. However, various models and measurements show different solar cycle SSI variability that lead to different modelled responses of ozone and temperature in the stratosphere, mainly due to the different UV variability in each model, and the global energy balance. The NRLSSI and SATIRE-S models are the most comprehensive reconstructions of solar irradiance variability for the period from 1978 to the present day. But while NRLSSI and SATIRE-S show similar solar cycle variability below 250 nm, between 250 and 400 nm SATIRE-S typically displays 50% larger variability, which is however, still significantly less then suggested by recent SORCE data. Due to large uncertainties and inconsistencies in some observational datasets, it is difficult to determine in a simple way which model is likely to be closer to the true solar variability. We review solar irradiance variability measurements and modelling and employ new analysis that sheds light on the causes of the discrepancies between the two models and with the observations.

  14. ASTRO-H CdTe detectors proton irradiation at PIF

    NASA Astrophysics Data System (ADS)

    Limousin, O.; Renaud, D.; Horeau, B.; Dubos, S.; Laurent, P.; Lebrun, F.; Chipaux, R.; Boatella Polo, C.; Marcinkowski, R.; Kawaharada, M.; Watanabe, S.; Ohta, M.; Sato, G.; Takahashi, T.

    2015-07-01

    ASTRO-H will be operated in a Low Earth Orbit with a 31° inclination at 550 km altitude, thus passing daily through the South Atlantic Anomaly radiation belt, a specially harsh environment where the detectors are suffering the effect of the interaction with trapped high energy protons. As CdTe detector performance might be affected by the irradiation, we investigate the effect of the accumulated proton fluence on their spectral response. To do so, we have characterized and irradiated representative samples of SGD and HXI detector under different conditions. The detectors in question, from ACRORAD, are single-pixels having a size of 2 mm by 2 mm and 750 μm thick. The Schottky contact is either made of an Indium or Aluminum for SGD and HXI respectively. We ran the irradiation test campaign at the Proton Irradiation Facility (PIF) at PSI, and ESA approved equipment to evaluate the radiation hardness of flight hardware. We simulated the proton flux expected on the sensors over the entire mission, and secondary neutrons flux due to primary proton interactions into the surrounding BGO active shielding. We eventually characterized the detector response evolution, emphasizing each detector spectral response as well as its stability by studying the so-called Polarization effect. The latter is provoking a spectral response degradation against time as a charge accumulation process occurs in Schottky type CdTe sensors. In this paper, we report on the test campaigns at PIF and will show up our experimental setup. We will pursue describing the irradiation conditions associated with our GEANT 4 predictions and finally, we report the main results of our campaigns concluding that the proton effect does not severely affect the CdTe response neither the detector stability while the secondary neutrons might be more active to reduce the performance on the long run.

  15. Changes and Attribution of Extreme Precipitation in Climate Models: Subdaily and Daily Scales

    NASA Astrophysics Data System (ADS)

    Zhang, W.; Villarini, G.; Scoccimarro, E.; Vecchi, G. A.

    2017-12-01

    Extreme precipitation events are responsible for numerous hazards, including flooding, soil erosion, and landslides. Because of their significant socio-economic impacts, the attribution and projection of these events is of crucial importance to improve our response, mitigation and adaptation strategies. Here we present results from our ongoing work.In terms of attribution, we use idealized experiments [pre-industrial control experiment (PI) and 1% per year increase (1%CO2) in atmospheric CO2] from ten general circulation models produced under the Coupled Model Intercomparison Project Phase 5 (CMIP5) and the fraction of attributable risk to examine the CO2 effects on extreme precipitation at the sub-daily and daily scales. We find that the increased CO2 concentration substantially increases the odds of the occurrence of sub-daily precipitation extremes compared to the daily scale in most areas of the world, with the exception of some regions in the sub-tropics, likely in relation to the subsidence of the Hadley Cell. These results point to the large role that atmospheric CO2 plays in extreme precipitation under an idealized framework. Furthermore, we investigate the changes in extreme precipitation events with the Community Earth System Model (CESM) climate experiments using the scenarios consistent with the 1.5°C and 2°C temperature targets. We find that the frequency of annual extreme precipitation at a global scale increases in both 1.5°C and 2°C scenarios until around 2070, after which the magnitudes of the trend become much weaker or even negative. Overall, the frequency of global annual extreme precipitation is similar between 1.5°C and 2°C for the period 2006-2035, and the changes in extreme precipitation in individual seasons are consistent with those for the entire year. The frequency of extreme precipitation in the 2°C experiments is higher than for the 1.5°C experiment after the late 2030s, particularly for the period 2071-2100.

  16. Longitudinal Investigation of Adaptive Functioning Following Conformal Irradiation for Pediatric Craniopharyngioma and Low-Grade Glioma

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Netson, Kelli L.; Conklin, Heather M.; Wu, Shengjie

    2013-04-01

    Purpose: Children treated for brain tumors with conformal radiation therapy experience preserved cognitive outcomes. Early evidence suggests that adaptive functions or independent-living skills may be spared. This longitudinal investigation prospectively examined intellectual and adaptive functioning during the first 5 years following irradiation for childhood craniopharyngioma and low-grade glioma (LGG). The effect of visual impairment on adaptive outcomes was investigated. Methods and Materials: Children with craniopharyngioma (n=62) and LGG (n=77) were treated using conformal or intensity modulated radiation therapy. The median age was 8.05 years (3.21-17.64 years) and 8.09 years (2.20-19.27 years), respectively. Serial cognitive evaluations including measures of intelligence quotientmore » (IQ) and the Vineland Adaptive Behavior Scales (VABS) were conducted at preirradiation baseline, 6 months after treatment, and annually through 5 years. Five hundred eighty-eight evaluations were completed during the follow-up period. Results: Baseline assessment revealed no deficits in IQ and VABS indices for children with craniopharyngioma, with significant (P<.05) longitudinal decline in VABS Communication and Socialization indices. Clinical factors associated with more rapid decline included females and preirradiation chemotherapy (interferon). The only change in VABS Daily Living Skills correlated with IQ change (r=0.34; P=.01) in children with craniopharyngioma. Children with LGG performed below population norms (P<.05) at baseline on VABS Communication, Daily Living Indices, and the Adaptive Behavior Composite, with significant (P<.05) longitudinal decline limited to VABS Communication. Older age at irradiation was a protective factor against longitudinal decline. Severe visual impairment did not independently correlate with poorer adaptive outcomes for either tumor group. Conclusions: There was relative sparing of postirradiation functional outcomes over time in

  17. Global Increase in UV Irradiance during the Past 30 Years (1979-2008) Estimated from Satellite Data

    NASA Technical Reports Server (NTRS)

    Herman, Jay R.

    2010-01-01

    Zonal average ultraviolet irradiance (flux ultraviolet, F(sub uv)) reaching the Earth's surface has significantly increased since 1979 at all latitudes except the equatorial zone. Changes are estimated in zonal average F(sub uv) caused by ozone and cloud plus aerosol reflectivity using an approach based on Beer's law for monochromatic and action spectrum weighted irradiances. For four different cases, it is shown that Beer's Law leads to a power law form similar to that applied to erythemal action spectrum weighted irradiances. Zonal and annual average increases in F(sub uv) were caused by decreases in ozone amount from 1979 to 1998. After 1998, midlatitude annual average ozone amounts and UV irradiance levels have been approximately constant. In the Southern Hemisphere, zonal and annual average UV increase is partially offset by tropospheric cloud and aerosol transmission decreases (hemispherical dimming), and to a lesser extent in the Northern Hemisphere. Ozone and 340 nm reflectivity changes have been obtained from multiple joined satellite time series from 1978 to 2008. The largest zonal average increases in F(sub uv) have occurred in the Southern Hemisphere. For clear-sky conditions at 50 S, zonal average F(sub uv) changes are estimated (305 nm, 23%; erythemal, 8.5%; 310 nm, 10%; vitamin D production, 12%). These are larger than at 50 N (305 nm, 9%; erythemal, 4%; 310 nm, 4%; vitamin D production, 6%). At the latitude of Buenos Aires, Argentina (34.6 S), the clear-sky Fuv increases are comparable to the increases near Washington, D. C. (38.9 N): 305 nm, 9% and 7%; erythemal, 6% and 4%; and vitamin D production, 7% and 5%, respectively.

  18. The Copernicus Atmosphere Monitoring Service: facilitating the prediction of air quality from global to local scales

    NASA Astrophysics Data System (ADS)

    Engelen, R. J.; Peuch, V. H.

    2017-12-01

    The European Copernicus Atmosphere Monitoring Service (CAMS) operationally provides daily forecasts of global atmospheric composition and regional air quality. The global forecasting system is using ECMWF's Integrated Forecasting System (IFS), which is used for numerical weather prediction and which has been extended with modules for atmospheric chemistry, aerosols and greenhouse gases. The regional forecasts are produced by an ensemble of seven operational European air quality models that take their boundary conditions from the global system and provide an ensemble median with ensemble spread as their main output. Both the global and regional forecasting systems are feeding their output into air quality models on a variety of scales in various parts of the world. We will introduce the CAMS service chain and provide illustrations of its use in downstream applications. Both the usage of the daily forecasts and the usage of global and regional reanalyses will be addressed.

  19. Daily workload in the embryology laboratory and in vitro fertilization results.

    PubMed

    Expósito, Antonia; Matorras, Roberto; Mendoza, Rosario; Crisol, Lorena; Martínez-Astorquiza, Txanton; Prieto, Begoña

    2010-01-01

    To ascertain if the daily activity in the in vitro fertilization (IVF) laboratory is related to pregnancy rates (PR) and fertilization rates (FR) in an IVF program. A retrospective study was performed to compare the PR and the FR obtained in 845 oocyte retrievals (OR) and 713 embryo transfers (ET), according to the daily workload. Different cutoffs were established: < or = 3 OR per day vs. > 3 OR per day; < or = 3 ET per day vs. > 3 ET per day, and also a cutoff considering the global activity in 3 different categories: optimal (level I), overload (level II) and high overload (level III), both the day of OR and of ET. The PR on the days with < or = 3 OR and with > 3 OR were similar, as were the days with < or = 3 ET or > 3 ET. There were no differences in PR when the activity the day of OR was level I, II or III (24.4%, 25.2% and 28.3%, respectively) or when the activity on the day of ET was level I, II or III (29.6%, 37.3% and 23.7%, respectively). We failed to show any adverse results on our IVF program associated with the daily workload.

  20. Time variation analysis of the daily Forbush decrease indices

    NASA Astrophysics Data System (ADS)

    Patra, Sankar Narayan; Ghosh, Koushik; Panja, Subhash Chandra

    2011-08-01

    In the present paper we have analyzed the daily Forbush decrease indices from January 1, 1967 to December 31, 2003. First filtering the time series by Simple Exponential Smoothing, we have applied Scargle Method of Periodogram on the processed time series in order to search for its time variation. Study exhibits periodicities around 174, 245, 261, 321, 452, 510, 571, 584, 662, 703, 735, 741, 767, 774, 820, 970, 1062, 1082, 1489, 1715, 2317, 2577, 2768, 3241 and 10630 days with confidence levels higher than 90%. Some of these periods are significantly similar to the observed periodicities of other solar activities, like solar filament activity, solar electron flare occurrence, solar-flare rate, solar proton events, solar neutrino flux, solar irradiance, cosmic ray intensity and flare, spectrum of the sunspot, solar wind, southern coronal hole area and solar cycle, which may suggest that the Forbush decrease behaves similarly to these solar activities and these activities may have a common origin.

  1. Measurement Variation and the Factors Influencing the UV Index

    ERIC Educational Resources Information Center

    Downs, Nathan; Parisi, Alfio; McDonnell, Brendan; Thornton, Peter

    2008-01-01

    The article presents a technique to measure the ultraviolet index using a personal hand-held ultraviolet meter to illustrate concepts of physics. Measurements of the erythemally effective (sun-burning) direct solar beam, diffuse skylight, and total global ultraviolet irradiance are converted to daily ultraviolet index measurements. Daily…

  2. Insulin-Like Growth Factor 1 Mitigates Hematopoietic Toxicity After Lethal Total Body Irradiation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Zhou, Dunhua; Deoliveira, Divino; Kang, Yubin

    2013-03-15

    Purpose: To investigate whether and how insulin-like growth factor 1 (IGF-1) mitigates hematopoietic toxicity after total body irradiation. Methods and Materials: BALB/c mice were irradiated with a lethal dose of radiation (7.5 Gy) and treated with IGF-1 at a dose of 100 μg/dose intravenously once a day for 5 consecutive days starting within 1 hour after exposure. Survival and hematopoietic recovery were monitored. The mechanisms by which IGF-1 promotes hematopoietic recovery were also studied by use of an in vitro culture system. Results: IGF-1 protected 8 of 20 mice (40%) from lethal irradiation, whereas only 2 of 20 mice (10%) inmore » the saline control group survived for more than 100 days after irradiation. A single dose of IGF-1 (500 μg) was as effective as daily dosing for 5 days. Positive effects were noted even when the initiation of treatment was delayed as long as 6 hours after irradiation. In comparison with the saline control group, treatment with IGF-1 significantly accelerated the recovery of both platelets and red blood cells in peripheral blood, total cell numbers, hematopoietic stem cells, and progenitor cells in the bone marrow when measured at day 14 after irradiation. IGF-1 protected both hematopoietic stem cells and progenitor cells from radiation-induced apoptosis and cell death. In addition, IGF-1 was able to facilitate the proliferation and differentiation of nonirradiated and irradiated hematopoietic progenitor cells. Conclusions: IGF-1 mitigates radiation-induced hematopoietic toxicity through protecting hematopoietic stem cells and progenitor cells from apoptosis and enhancing proliferation and differentiation of the surviving hematopoietic progenitor cells.« less

  3. IRRADIATION PROCTITIS

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bishop, J.F.

    1963-03-01

    The incidence, pathology, symptoms, and treatment of radiation injury of the distal large bowel resulting from Ra or x-ray therapy of uterine cervical cancer are surveyed, and observations on 25 cases of irradiation proctitis are presented. In this series of patierts the incidence of significart rectal injury following irradiation of cervical cancer was approximates 10%. Each of the 25 women had symptoms sufficiently distressing so that the radiologist, gynecologist, or family doctor felt specialized care was needed. The histopathology of irradiation proctitis presented varying degrees of damage to the rectal epithelium. With severe injury, outright cell death occurred, whereas withmore » lesser involvemert, there were irregular areas of ulceration and a definite lag in the healing process. There were varying degrees of fibrosis and thickening of collagen and muscle fibers, which often resulted in loss of elasticity of the rectal wall, along with fixation of the mucosa to the underlying scar tissue and muscle. Gross pathology presented a variable picture. A few patients experienced first symptoms 3 to 4 months after the completion of treatment, but the largest group noticed the onset of difficulties from 6 to 9 months after trentment. Others had an even longer interval of a year or two, and three had no symptoms until between three and five years later. The symptoms varied with the severity of the involvement. Where rectal bleeding and tenesmus occurred and bowel damage was not excessive, ora1 steroids were of great value. Prednisone was used, beginning with 5 mg every 6 hr and increasing or decreasing in dosage in accordance with the response. As improvement occurred, the minimum maintenance dosage was sought, and when it was found it sometimes had to be continued for months. One patient needed 5 mg daily or on alternate days for 2 years, to prevent recurrence of bleeding. Hectal instillation of various therapeutic substances has been recommended but steroid

  4. Status of Post Irradiation Examination of FCAB and FCAT Irradiation Capsules

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Field, Kevin G.; Yamamoto, Yukinori; Howard, Richard H.

    A series of irradiation programs are ongoing to address the need for determining the radiation tolerance of FeCrAl alloys. These irradiation programs, deemed the FCAT and FCAB irradiation programs, use the High Flux Isotope Reactor (HFIR) to irradiate second generation wrought FeCrAl alloys and early-generation powder-metallurgy (PM) oxide dispersion-strengthened (ODS) FeCrAl alloys. Irradiations have been or are being performed at temperatures of 200°C, 330°C, and 550°C from doses of 1.8 dpa up to 16 dpa. Preliminary post-irradiation examination (PIE) on low dose (<2 dpa) irradiation capsules of tensile specimens has been performed. Analysis of co-irradiated SiC thermometry have shown reasonablemore » matching between the nominal irradiation temperatures and the target irradiation temperatures. Room temperature tensile tests have shown typical radiation-induced hardening and embrittlement at irradiations of 200°C and 330°C, but a propensity for softening when irradiated to 550°C for the wrought alloys. The PM-ODS FeCrAl specimens showed less hardening compared to the wrought alloys. Future PIE includes high temperature tensile tests on the low dose irradiation capsules as well as the determination of reference fracture toughness transition temperature, T o, in alloys irradiated to 7 dpa and higher.« less

  5. Evaluation of the Global Land Data Assimilation System (GLDAS) air temperature data products

    USGS Publications Warehouse

    Ji, Lei; Senay, Gabriel B.; Verdin, James P.

    2015-01-01

    There is a high demand for agrohydrologic models to use gridded near-surface air temperature data as the model input for estimating regional and global water budgets and cycles. The Global Land Data Assimilation System (GLDAS) developed by combining simulation models with observations provides a long-term gridded meteorological dataset at the global scale. However, the GLDAS air temperature products have not been comprehensively evaluated, although the accuracy of the products was assessed in limited areas. In this study, the daily 0.25° resolution GLDAS air temperature data are compared with two reference datasets: 1) 1-km-resolution gridded Daymet data (2002 and 2010) for the conterminous United States and 2) global meteorological observations (2000–11) archived from the Global Historical Climatology Network (GHCN). The comparison of the GLDAS datasets with the GHCN datasets, including 13 511 weather stations, indicates a fairly high accuracy of the GLDAS data for daily temperature. The quality of the GLDAS air temperature data, however, is not always consistent in different regions of the world; for example, some areas in Africa and South America show relatively low accuracy. Spatial and temporal analyses reveal a high agreement between GLDAS and Daymet daily air temperature datasets, although spatial details in high mountainous areas are not sufficiently estimated by the GLDAS data. The evaluation of the GLDAS data demonstrates that the air temperature estimates are generally accurate, but caution should be taken when the data are used in mountainous areas or places with sparse weather stations.

  6. Forecasting daily streamflow using online sequential extreme learning machines

    NASA Astrophysics Data System (ADS)

    Lima, Aranildo R.; Cannon, Alex J.; Hsieh, William W.

    2016-06-01

    While nonlinear machine methods have been widely used in environmental forecasting, in situations where new data arrive continually, the need to make frequent model updates can become cumbersome and computationally costly. To alleviate this problem, an online sequential learning algorithm for single hidden layer feedforward neural networks - the online sequential extreme learning machine (OSELM) - is automatically updated inexpensively as new data arrive (and the new data can then be discarded). OSELM was applied to forecast daily streamflow at two small watersheds in British Columbia, Canada, at lead times of 1-3 days. Predictors used were weather forecast data generated by the NOAA Global Ensemble Forecasting System (GEFS), and local hydro-meteorological observations. OSELM forecasts were tested with daily, monthly or yearly model updates. More frequent updating gave smaller forecast errors, including errors for data above the 90th percentile. Larger datasets used in the initial training of OSELM helped to find better parameters (number of hidden nodes) for the model, yielding better predictions. With the online sequential multiple linear regression (OSMLR) as benchmark, we concluded that OSELM is an attractive approach as it easily outperformed OSMLR in forecast accuracy.

  7. Preventing Electromagnetic Pulse Irradiation Damage on Testis Using Selenium-rich Cordyceps Fungi. A Preclinical Study in Young Male Mice.

    PubMed

    Miao, Xia; Wang, Yafeng; Lang, Haiyang; Lin, Yanyun; Guo, Qiyan; Yang, Mingjuan; Guo, Juan; Zhang, Yanjun; Zhang, Jie; Liu, Junye; Liu, Yaning; Zeng, Lihua; Guo, Guozhen

    2017-02-01

    Networked 21st century society, globalization, and communications technologies are paralleled by the rise of electromagnetic energy intensity in our environments and the growing pressure of the environtome on human biology and health. The latter is the entire complement of environmental factors, including the electromagnetic energy and the technologies that generate them, enacting on the digital citizen in the new century. Electromagnetic pulse (EMP) irradiation might have serious damaging effects not only on electronic equipment but also in the whole organism and reproductive health, through nonthermal effects and oxidative stress. We sought to determine whether EMP exposure (1) induces biological damage on reproductive health and (2) the extent to which selenium-rich Cordyceps fungi (daily coadministration) offer protection on the testicles and spermatozoa. In a preclinical randomized study, 3-week-old male BALB/c mice were repeatedly exposed to EMP (peak intensity 200 kV/m, pulse edge 3.5 ns, pulse width 15 ns, 0.1 Hz, and 400 pulses/day) 5 days per week for four consecutive weeks, with or without coadministration of daily selenium-rich Cordyceps fungi (100 mg/kg). Testicular index and spermatozoa formation were measured at baseline and 1, 7, 14, 28, and 60 day time points after EMP exposure. The group without Cordyceps cotreatment displayed decreased spermatozoa formation, shrunk seminiferous tubule diameters, and diminished antioxidative capacity at 28 and 60 days after exposure (p < 0.05). The Cordyceps daily cotreatment alleviated the testicular damage by EMP exposure, increased spermatozoa formation, and reduced apoptotic spermatogenic cells. These observations warrant further preclinical and clinical studies as an innovative approach for potential protection against electromagnetic radiation in the current age of networked society and digital citizenship.

  8. Production of ochratoxin A by Aspergillus ochraceus NRRL-3174 before and after exposures to 60Co irradiation.

    PubMed Central

    Applegate, K L; Chipley, J R

    1976-01-01

    Spores from the toxigenic organism Aspergillus ochraceus NRRL-3174 were exposed to specific levels of gamma irradiation and then allowed to germinate on selected media. Increases in ochratoxin A production by irradiated, compared to non-irradiated, spores were observed after inoculation of spores onto a cracked red wheat or into a synthetic liquid medium. Variations in daily ochratoxin production were also observed for control and irradiated spore-derived cultures developing on both media, with maximum toxin production varying from 7 to 11 days of incubation. The most notable increases in ochratoxin A production occurred from cultures developing from spores having been irradiated with 10, 25, or 50 krad. Exposures to 400 or 600 krad resulted in complete inhibition of spore germination and, consequently, no ochratoxin production. Of the two substrates used, wheat and synthetic, the quantities of ochratoxin A produced were significantly lower in the synthetic media than on the natural substrate. Higher and more rapid toxin production occurred from spores having been irradiated with 10, 25, 50, and 100 krad than occurred from the non-irradiated control spores when grown on synthetic media. Cultures derived from spores having been exposed to 10, 25, 50, and 100 krad produced significantly higher levels of ochratoxin A after 8 days of incubation on natural substrate than did the controls. Analysis of variance revealed that substrate, length of incubation, as well as irradiation levels all affected the time required to produce maximum levels of ochratoxin A. PMID:938031

  9. Integrating Research on Global Climate Change and Human Use of the Oceans: a Geospatial Method for Daily Monitoring of Sea Ice and Ship Traffic in the Arctic

    NASA Astrophysics Data System (ADS)

    Eucker, W.; McGillivary, P. A.

    2012-12-01

    One apparent consequence of global climate change has been a decrease in the extent and thickness of Arctic sea ice more rapidly than models have predicted, while Arctic ship traffic has likewise increased beyond economic predictions. To ensure representative observations of changing climate conditions and human use of the Arctic Ocean, we concluded a method of tracking daily changes in both sea ice and shipping in the Arctic Ocean was needed. Such a process improves the availability of sea ice data for navigational safety and allows future developments to be monitored for understanding of ice and shipping in relation to policy decisions appropriate to optimize sustainable use of a changing Arctic Ocean. The impetus for this work was the 2009 Arctic Marine Shipping Assessment (AMSA) which provided baseline data on Arctic ship traffic. AMSA was based on responses from circumpolar countries, was manpower intensive, and took years to compile. A more timely method of monitoring human use of the Arctic Ocean was needed. To address this, a method of monitoring sea ice on a scale relevant to ship-navigation (<10km) was developed and implemented in conjunction with arctic ship tracking using S-AIS (Satellite Automatic Identification Systems). S-AIS is internationally required on ships over a certain size, which includes most commercial vessels in the Arctic Ocean. Daily AIS and sea ice observations were chosen for this study. Results of this method of geospatial analysis of the entire arctic are presented for a year long period from April 1, 2010 to March 31, 2011. This confirmed the dominance of European Arctic ship traffic. Arctic shipping is maximal during August and diminishes in September with a minimum in winter, although some shipping continues year-round in perennially ice-free areas. Data are analyzed for the four principal arctic quadrants around the North Pole by season for number and nationality of vessels. The goal of this study was not merely to monitor ship

  10. Object Perception Impairments Predict Instrumental Activities of Daily Living Dependence in Alzheimer's Disease

    PubMed Central

    JEFFERSON, ANGELA L.; BARAKAT, LAMIA P.; GIOVANNETTI, TANIA; PAUL, ROBERT H.; GLOSSER, GUILA

    2009-01-01

    This study examined the contribution of object perception and spatial localization to functional dependence among Alzheimer's disease (AD) patients. Forty patients with probable AD completed measures assessing verbal recognition memory, working memory, object perception, spatial localization, semantic knowledge, and global cognition. Primary caregivers completed a measure of activities of daily living (ADLs) that included instrumental and basic self-care subscales (i.e., IADLs and BADLs, respectively). Stepwise multiple regressions revealed that global cognition accounted for significant portions of variance among the ADL total, IADL, and BADL scores. However, when global cognition was removed from the model, object perception was the only significant cognitive predictor of the ADL total and IADL subscale scores, accounting for 18.5% and 19.3% of the variance, respectively. When considering multiple cognitive components simultaneously, object perception and the integrity of the inferotemporal cortex is important in the completion of functional abilities in general and IADLs in particular among AD patients. PMID:16822730

  11. Effects of a turmeric extract (Curcuma longa) on chronic ultraviolet B irradiation-induced skin damage in melanin-possessing hairless mice.

    PubMed

    Sumiyoshi, Maho; Kimura, Yoshiyuki

    2009-12-01

    Turmeric (the rhizomes of Curcuma longa L., Zingiberacease) is widely used as a dietary pigment and spice, and has been traditionally used for the treatment of inflammation, skin wounds and hepatic disorders in Ayurvedic, Unani and Chinese medicine. Although the topical application or oral administration of turmeric is used to improve skin trouble, there is no evidence to support this effect. The aim of this study was to clarify whether turmeric prevents chronic ultraviolet B (UVB)-irradiated skin damage. We examined the effects of a turmeric extract on skin damage including changes in skin thickness and elasticity, pigmentation and wrinkling caused by long-term, low-dose ultraviolet B irradiation in melanin-possessing hairless mice. The extract (at 300 or 1000 mg/kg, twice daily) prevented an increase in skin thickness and a reduction in skin elasticity induced by chronic UVB exposure. It also prevented the formation of wrinkles and melanin (at 1000 mg/kg, twice daily) as well as increases in the diameter and length of skin blood vessels and in the expression of matrix metalloproteinase-2 (MMP-2). Prevention of UVB-induced skin aging by turmeric may be due to the inhibition of increases in MMP-2 expression caused by chronic irradiation.

  12. Positioning accuracy during VMAT of gynecologic malignancies and the resulting dosimetric impact by a 6-degree-of-freedom couch in combination with daily kilovoltage cone beam computed tomography.

    PubMed

    Yao, Lihong; Zhu, Lihong; Wang, Junjie; Liu, Lu; Zhou, Shun; Jiang, ShuKun; Cao, Qianqian; Qu, Ang; Tian, Suqing

    2015-04-26

    To improve the delivery of radiotherapy in gynecologic malignancies and to minimize the irradiation of unaffected tissues by using daily kilovoltage cone beam computed tomography (kV-CBCT) to reduce setup errors. Thirteen patients with gynecologic cancers were treated with postoperative volumetric-modulated arc therapy (VMAT). All patients had a planning CT scan and daily CBCT during treatment. Automatic bone anatomy matching was used to determine initial inter-fraction positioning error. Positional correction on a six-degrees-of-freedom (6DoF) couch was followed by a second scan to calculate the residual inter-fraction error, and a post-treatment scan assessed intra-fraction motion. The margins of the planning target volume (MPTV) were calculated from these setup variations and the effect of margin size on normal tissue sparing was evaluated. In total, 573 CBCT scans were acquired. Mean absolute pre-/post-correction errors were obtained in all six planes. With 6DoF couch correction, the MPTV accounting for intra-fraction errors was reduced by 3.8-5.6 mm. This permitted a reduction in the maximum dose to the small intestine, bladder and femoral head (P=0.001, 0.035 and 0.032, respectively), the average dose to the rectum, small intestine, bladder and pelvic marrow (P=0.003, 0.000, 0.001 and 0.000, respectively) and markedly reduced irradiated normal tissue volumes. A 6DoF couch in combination with daily kV-CBCT can considerably improve positioning accuracy during VMAT treatment in gynecologic malignancies, reducing the MPTV. The reduced margin size permits improved normal tissue sparing and a smaller total irradiated volume.

  13. Characterization of Irradiated and Non-Irradiated Rubber from Automotive Scrap Tires

    NASA Astrophysics Data System (ADS)

    Souza, Clécia Moura; Silva, Leonardo G.

    The aim of this work was to characterize the samples of irradiated and non-irradiated rubber from automotive scrap tires. Rubber samples from scrap tires were irradiated at irradiation doses of 200, 400 and 600kGy in an electron beam accelerator. Subsequently, both the irradiated and non-irradiated samples were characterized by thermogravimetry (TG), differential scanning calorimetry (DSC), tensile strength mechanical test, and Fourier transform infrared (FTIR) spectrophotometry.

  14. Development of AM 1.5 global measurement procedures and international cell measurement round robin

    NASA Technical Reports Server (NTRS)

    Mueller, R.

    1985-01-01

    The development of the capability for measurement under global irradiance spectral distribution is reported. The airmass 1.5 global measurement procedure is given. Also given is the procedure and justification for using the large area pulsed solar simulator (LAPSS). The status of the international round robin of reference cell measurements managed by the Commission of European Communities (CEC) is described.

  15. The impact of cigarette tax increase on smoking behavior of daily smokers.

    PubMed

    Kengganpanich, Mondha; Termsirikulchai, Lakkhana; Benjakul, Sarunya

    2009-12-01

    To assess the impact of excise tax increase on smoking behavior of daily smokers aged 15 years and over and to explore the association between smokers' characteristics and smoking behavior prior and after excise tax increase. This cross-sectional survey was performed in 504 daily smokers, who were selected from data records of Global Adult Tobacco Survey (GATS) between February and April, 2009. The data were collected by telephone interview in the first and second weeks of July, 2009. Data were analyzed by frequency distribution and binary logistic regression. After the cigarette tax increase, 9.7% of daily smokers quitted smoking and 48.0% reduced the amount of cigarettes and/or changed the brands and types of tobacco, from manufactured cigarettes to hand-rolled cigarettes. After other covariance being adjusted, the analysis revealed that the amount of cigarettes per day, the types of cigarettes (manufactured and hand-rolled cigarettes), and the smokers' reaction towards the increased price after the excise tax increase were respectively associated with the fact that the smokers quitted smoking or reduced the amount of cigarettes (p < 0.05). Cigarette tax increase is beneficial for government revenue and it also affects smoking behavior change of daily smokers. However Ministry of Public Health should co-operate with Ministry of Finance to raise the tax rate on both cigarettes and hand-rolled cigarettes continuously and provide sufficient cessation service to respond to the need to quit smoking.

  16. Cost analysis of once-daily ISMN versus twice-daily ISMN or transdermal patch for nitrate prophylaxis.

    PubMed

    Brown, R E; Kendall, M J; Halpern, M T

    1997-02-01

    To compare the costs and outcomes of treating exercise-induced angina with once- or twice-daily isosorbide mononitrate (ISMN) or transdermal patch. A decision-analytic model was designed based on published literature showing compliance and increasing symptoms and estimates from physicians on treatment patterns and worsening symptoms. Data show that patients are more compliant with once-daily ISMN (Imdur, Astra Hässle, Mölndal, Sweden) and patch regimens than with twice-daily dose. Based upon the assumption that more compliant patients are better controlled, the model found that fewer medical care resources were consumed by patients treated with the once-daily and the patch regimens. The unit cost of the twice-daily ISMN regimen is 40% of the unit cost of the once-daily. Annual costs of treating an exercise-induced angina patient are 248 pounds for Imdur compared to 250 pounds for the twice-daily ISMN and 299 pounds for the transdermal patch. Unit prices alone are not good indicators for estimating medical management costs.

  17. Combination of radar and daily precipitation data to estimate meaningful sub-daily point precipitation extremes

    NASA Astrophysics Data System (ADS)

    Pegram, Geoff; Bardossy, Andras; Sinclair, Scott

    2017-04-01

    The use of radar measurements for the space time estimation of precipitation has for many decades been a central topic in hydro-meteorology. In this presentation we are interested specifically in daily and sub-daily extreme values of precipitation at gauged or ungauged locations which are important for design. The purpose of the presentation is to develop a methodology to combine daily precipitation observations and radar measurements to estimate sub-daily extremes at point locations. Radar data corrected using precipitation-reflectivity relationships lead to biased estimations of extremes. Different possibilities of correcting systematic errors using the daily observations are investigated. Observed gauged daily amounts are interpolated to un-sampled points and subsequently disaggregated using the sub-daily values obtained by the radar. Different corrections based on the spatial variability and the sub-daily entropy of scaled rainfall distributions are used to provide unbiased corrections of short duration extremes. In addition, a statistical procedure not based on a matching day by day correction is tested. In this last procedure, as we are only interested in rare extremes, low to medium values of rainfall depth were neglected leaving 12 days of ranked daily maxima in each set per year, whose sum typically comprises about 50% of each annual rainfall total. The sum of these 12 day maxima is first interpolated using a Kriging procedure. Subsequently this sum is disaggregated to daily values using a nearest neighbour procedure. The daily sums are then disaggregated by using the relative values of the biggest 12 radar based days in each year. Of course, the timings of radar and gauge maxima can be different, so the new method presented here uses radar for disaggregating daily gauge totals down to 15 min intervals in order to extract the maxima of sub-hourly through to daily rainfall. The methodologies were tested in South Africa, where an S-band radar operated

  18. Global health: the ethical responsibility of the pharmaceutical industry.

    PubMed

    Lassen, Lars Christian; Thomsen, Mads Krogsgaard

    2007-02-01

    Health as a global issue concerns all and clearly manifests global inequality. All stakeholders of the healthcare systems and disease treatment--including the pharmaceutical industry--have an ethical obligation to contribute to promoting global health. At Novo Nordisk we primarily focus on providing our contribution to global health through defeating diabetes. At the same time we stand by being a private company required to deliver a financial profit, which is why we must create positive results on the financial, the environmental and the social bottom lines. In this article we attempt to provide a brief overview of some of the initiatives that we think business companies can take--and therefore are also obliged to in promoting global health. Further, we have pointed out a number of dilemmas within research and development as well as business ethics that all companies face when they convert the ethical principles to daily practice globally.

  19. Combination of radar and daily precipitation data to estimate meaningful sub-daily point precipitation extremes

    NASA Astrophysics Data System (ADS)

    Bárdossy, András; Pegram, Geoffrey

    2017-01-01

    The use of radar measurements for the space time estimation of precipitation has for many decades been a central topic in hydro-meteorology. In this paper we are interested specifically in daily and sub-daily extreme values of precipitation at gauged or ungauged locations which are important for design. The purpose of the paper is to develop a methodology to combine daily precipitation observations and radar measurements to estimate sub-daily extremes at point locations. Radar data corrected using precipitation-reflectivity relationships lead to biased estimations of extremes. Different possibilities of correcting systematic errors using the daily observations are investigated. Observed gauged daily amounts are interpolated to unsampled points and subsequently disaggregated using the sub-daily values obtained by the radar. Different corrections based on the spatial variability and the subdaily entropy of scaled rainfall distributions are used to provide unbiased corrections of short duration extremes. Additionally a statistical procedure not based on a matching day by day correction is tested. In this last procedure as we are only interested in rare extremes, low to medium values of rainfall depth were neglected leaving a small number of L days of ranked daily maxima in each set per year, whose sum typically comprises about 50% of each annual rainfall total. The sum of these L day maxima is first iterpolated using a Kriging procedure. Subsequently this sum is disaggregated to daily values using a nearest neighbour procedure. The daily sums are then disaggregated by using the relative values of the biggest L radar based days. Of course, the timings of radar and gauge maxima can be different, so the method presented here uses radar for disaggregating daily gauge totals down to 15 min intervals in order to extract the maxima of sub-hourly through to daily rainfall. The methodologies were tested in South Africa, where an S-band radar operated relatively continuously at

  20. Evaluation of radio-protective effect of melatonin on whole body irradiation induced liver tissue damage.

    PubMed

    Shirazi, Alireza; Mihandoost, Ehsan; Ghobadi, Ghazale; Mohseni, Mehran; Ghazi-Khansari, Mahmoud

    2013-01-01

    Ionizing radiation interacts with biological systems to induce excessive fluxes of free radicals that attack various cellular components. Melatonin has been shown to be a direct free radical scavenger and indirect antioxidant via its stimulatory actions on the antioxidant system.The aim of this study was to evaluate the antioxidant role of melatonin against radiation-induced oxidative injury to the rat liver after whole body irradiation. In this experimental study,thirty-two rats were divided into four groups. Group 1 was the control group, group 2 only received melatonin (30 mg/kg on the first day and 30 mg/kg on the following days), group 3 only received whole body gamma irradiation of 10 Gy, and group 4 received 30 mg/kg melatonin 30 minutes prior to radiation plus whole body irradiation of 10 Gy plus 30 mg/kg melatonin daily through intraperitoneal (IP) injection for three days after irradiation. Three days after irradiation, all rats were sacrificed and their livers were excised to measure the biochemical parameters malondialdehyde (MDA) and glutathione (GSH). Each data point represents mean ± standard error on the mean (SEM) of at least eight animals per group. A one-way analysis of variance (ANOVA) was performed to compare different groups, followed by Tukey's multiple comparison tests (p<0.05). The results demonstrated that whole body irradiation induced liver tissue damage by increasing MDA levels and decreasing GSH levels. Hepatic MDA levels in irradiated rats that were treated with melatonin (30 mg/kg) were significantly decreased, while GSH levels were significantly increased, when compared to either of the control groups or the melatonin only group. The data suggest that administration of melatonin before and after irradiation may reduce liver damage caused by gamma irradiation.

  1. Successful pregnancy after total body irradiation and bone marrow transplantation for acute leukaemia.

    PubMed

    Giri, N; Vowels, M R; Barr, A L; Mameghan, H

    1992-07-01

    We report successful pregnancies in two young women (aged 24 and 20 years) following allogeneic bone marrow transplantation (BMT) for acute non-lymphoblastic leukaemia. Conditioning therapy consisted of cyclophosphamide (120 mg/kg) and total body irradiation (TBI, 12 Gy) in 2 Gy fractions once daily for 6 days or twice daily for 3 days. Graft-versus-host disease prophylaxis was with methotrexate alone. Both women were amenorrhoeic after BMT and gonadal testing indicated hypergonadotrophic hypogonadism. Both women had normal pregnancies (2 years and 5 years after BMT) resulting in normal healthy infants. Previously successful pregnancy has been reported after TBI in three women in whom the TBI dose was less than 8 Gy. Our cases illustrate that normal outcome of pregnancy is possible at even higher doses of TBI.

  2. Inter-comparison of daily precipitation products for large-scale hydro-climatic applications over Canada

    NASA Astrophysics Data System (ADS)

    Wong, Jefferson S.; Razavi, Saman; Bonsal, Barrie R.; Wheater, Howard S.; Asong, Zilefac E.

    2017-04-01

    A number of global and regional gridded climate products based on multiple data sources are available that can potentially provide reliable estimates of precipitation for climate and hydrological studies. However, research into the consistency of these products for various regions has been limited and in many cases non-existent. This study inter-compares several gridded precipitation products over 15 terrestrial ecozones in Canada for different seasons. The spatial and temporal variability of the errors (relative to station observations) was quantified over the period of 1979 to 2012 at a 0.5° and daily spatio-temporal resolution. These datasets were assessed in their ability to represent the daily variability of precipitation amounts by four performance measures: percentage of bias, root mean square error, correlation coefficient, and standard deviation ratio. Results showed that most of the datasets were relatively skilful in central Canada. However, they tended to overestimate precipitation amounts in the west and underestimate in the north and east, with the underestimation being particularly dominant in northern Canada (above 60° N). The global product by WATCH Forcing Data ERA-Interim (WFDEI) augmented by Global Precipitation Climatology Centre (GPCC) data (WFDEI [GPCC]) performed best with respect to different metrics. The Canadian Precipitation Analysis (CaPA) product performed comparably with WFDEI [GPCC]; however, it only provides data starting in 2002. All the datasets performed best in summer, followed by autumn, spring, and winter in order of decreasing quality. Findings from this study can provide guidance to potential users regarding the performance of different precipitation products for a range of geographical regions and time periods.

  3. Variability in solar irradiance observed at two contrasting Antarctic sites

    NASA Astrophysics Data System (ADS)

    Petkov, Boyan H.; Láska, Kamil; Vitale, Vito; Lanconelli, Christian; Lupi, Angelo; Mazzola, Mauro; Budíková, Marie

    2016-05-01

    The features of erythemally weighted (EW) and short-wave downwelling (SWD) solar irradiances, observed during the spring-summer months of 2007-2011 at Johann Gregor Mendel (63°48‧S, 57°53‧W, 7 m a.s.l.) and Dome Concordia (75°06‧S, 123°21‧E, 3233 m a.s.l.) stations, placed at the Antarctic coastal region and on the interior plateau respectively, have been analysed and compared to each other. The EW and SWD spectral components have been presented by the corresponding daily integrated values and were examined taking into account the different geographic positions and different environmental conditions at both sites. The results indicate that at Mendel station the surface solar irradiance is strongly affected by the changes in the cloud cover, aerosols and albedo that cause a decrease in EW between 20% and 35%, and from 0% to 50% in SWD component, which contributions are slightly lower than the seasonal SWD variations evaluated to be about 71%. On the contrary, the changes in the cloud cover features at Concordia station produce only a 5% reduction of the solar irradiance, whilst the seasonal oscillations of 94% turn out to be the predominant mode. The present analysis leads to the conclusion that the variations in the ozone column cause an average decrease of about 46% in EW irradiance with respect to the value found in the case of minimum ozone content at each of the stations. In addition, the ratio between EW and SWD spectral components can be used to achieve a realistic assessment of the radiation amplification factor that quantifies the relationship between the atmospheric ozone and the surface UV irradiance.

  4. Mice receiving infrared irradiation have a higher survival rate under forced swimming in cold.

    PubMed

    Tsai, Jui-Feng

    2009-10-01

    To explore the effect of infrared (IR) irradiation on the survival rates of mice under forced swimming in cold conditions. IR irradiation has been found to be beneficial for wound healing, tumor reduction, pain relief, and even against depression. However, whether the antidepressant effect of IR irradiation came from heat has remained unanswered. The goals of the study were originally aimed at using an animal model for depression to understand the relationship between the antidepressant effect of IR irradiation and hyperthermia as well as seasonality. Forty-four mice were housed in cages in a room subject to the outdoor temperature, and randomly assigned to the IR-treated group (n = 15), the heat-treated group (n = 14), and the control group (n = 15) during winter. The mice of the IR-treated group received whole-body IR irradiation for 60 min daily, while the heat-treated group received heat diffusion to reach the same temperature level. The control group received neither IR nor heat. All groups of mice underwent a forced swimming test weekly. Incidentally, two episodes of cold current occurred during the study period, and some mice died. The survival rates were compared pairwise against the control. The IR-treated group had a significantly reduced relative risk (p = 0.013) when compared with the control group, while the heat-treated group did not show any significant reduction (p = 0.087). There was no significant difference in body temperatures of the three groups before and after the irradiation. IR irradiation resulted in a significantly higher survival rate for mice that were concurrently subjected to cold and a forced swimming test. This result may be beyond the thermal effect.

  5. Sharing Data to Build a Medical Information Commons: From Bermuda to the Global Alliance.

    PubMed

    Cook-Deegan, Robert; Ankeny, Rachel A; Maxson Jones, Kathryn

    2017-08-31

    The Human Genome Project modeled its open science ethos on nematode biology, most famously through daily release of DNA sequence data based on the 1996 Bermuda Principles. That open science philosophy persists, but daily, unfettered release of data has had to adapt to constraints occasioned by the use of data from individual people, broader use of data not only by scientists but also by clinicians and individuals, the global reach of genomic applications and diverse national privacy and research ethics laws, and the rising prominence of a diverse commercial genomics sector. The Global Alliance for Genomics and Health was established to enable the data sharing that is essential for making meaning of genomic variation. Data-sharing policies and practices will continue to evolve as researchers, health professionals, and individuals strive to construct a global medical and scientific information commons.

  6. Rapid differentiation between gamma-irradiated and non irradiated potato tubers

    NASA Astrophysics Data System (ADS)

    Jona, Roberto; Fronda, Anna

    The use of gamma irradiation as commercial method for the preservation of fruits and vegetables calls for methods of differentiation between irradiated and non-irradiated foodstuffs. In a previous research, the polysaccharidic content of cell walls of irradiated tissue has been investigated, but it required rather long time to reach the result. A method devised to ascertain the vitality of cells has been applied to distinguish irradiated from non-irradiated potato tubers. 500 mg of tissue excised from tubers have been infiltrated with tetrazolium chloride 0.6% in phosphate buffer, pH 7.4. After 15 hrs of incubation at 30°C the treated tissues have been extracted with 95% ethanol whose O.D. has been measured at 530 mμ wavelength. The colour intensity of the alcohol allowed a very clearcut recognition of the irradiated tubers.

  7. Imaging Fourier Transform Spectroscopy of the Boundary Layer Plume from Laser Irradiated Polymers and Carbon Materials

    DTIC Science & Technology

    2014-06-16

    with surface desorption of the monomer. For laser-irradiated porous graphite targets, experimental results indicated a dominant CO2 production at...global models [78, 79, 87-89]. For simplicity, established global kinetics are considered and compare with experimental results obtained from IFTS...investigated up to 3 mm away from the surface into the boundary layer. At 0.72 mm from the surface, experimental results indicated a dominant production of

  8. Quantification of Daily Physical Activity

    NASA Technical Reports Server (NTRS)

    Whalen, Robert; Breit, Greg; Quintana, Jason

    1994-01-01

    The influence of physical activity on the maintenance and adaptation of musculoskeletal tissue is difficult to assess. Cumulative musculoskeletal loading is hard to quantify and the attributes of the daily tissue loading history affecting bone metabolism have not been completely identified. By monitoring the vertical component of the daily ground reaction force (GRFz), we have an indirect measure of cumulative daily lower limb musculoskeletal loading to correlate with bone density and structure. The objective of this research is to develop instrumentation and methods of analysis to quantify activity level in terms of the daily history of ground reaction forces.

  9. Hypoxia-Inducible Factor Pathway Inhibition Resolves Tumor Hypoxia and Improves Local Tumor Control After Single-Dose Irradiation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Helbig, Linda; Department of Radiation Oncology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden; Koi, Lydia

    2014-01-01

    Purpose: To study the effects of BAY-84-7296, a novel orally bioavailable inhibitor of mitochondrial complex I and hypoxia-inducible factor 1 (HIF-1) activity, on hypoxia, microenvironment, and radiation response of tumors. Methods and Materials: UT-SCC-5 and UT-SCC-14 human squamous cell carcinomas were transplanted subcutaneously in nude mice. When tumors reached 4 mm in diameter BAY-84-7296 (Bayer Pharma AG) or carrier was daily administered to the animals. At 7 mm tumors were either excised for Western blot and immunohistologic investigations or were irradiated with single doses. After irradiation animals were randomized to receive BAY-84-7296 maintenance or carrier. Local tumor control was evaluatedmore » 150 days after irradiation, and the dose to control 50% of tumors (TCD{sub 50}) was calculated. Results: BAY-84-7296 decreased nuclear HIF-1α expression. Daily administration of inhibitor for approximately 2 weeks resulted in a marked decrease of pimonidazole hypoxic fraction in UT-SCC-5 (0.5% vs 21%, P<.0001) and in UT-SCC-14 (0.3% vs 19%, P<.0001). This decrease was accompanied by a significant increase in fraction of perfused vessels in UT-SCC-14 but not in UT-SCC-5. Bromodeoxyuridine and Ki67 labeling indices were significantly reduced only in UT-SCC-5. No significant changes were observed in vascular area or necrosis. BAY-84-7296 before single-dose irradiation significantly decreased TCD{sub 50}, with an enhancement ratio of 1.37 (95% confidence interval [CI] 1.13-1.72) in UT-SCC-5 and of 1.55 (95% CI 1.26-1.94) in UT-SCC-14. BAY-84-7296 maintenance after irradiation did not further decrease TCD{sub 50}. Conclusions: BAY-84-7296 resulted in a marked decrease in tumor hypoxia and substantially reduced radioresistance of tumor cells with the capacity to cause a local recurrence after irradiation. The data suggest that reduction of cellular hypoxia tolerance by BAY-84-7296 may represent the primary biological mechanism underlying the observed enhancement

  10. Comparison of Irradiation and Wolbachia Based Approaches for Sterile-Male Strategies Targeting Aedes albopictus

    PubMed Central

    Atyame, Célestine M.; Labbé, Pierrick; Lebon, Cyrille; Weill, Mylène; Moretti, Riccardo; Marini, Francesca; Gouagna, Louis Clément; Calvitti, Maurizio; Tortosa, Pablo

    2016-01-01

    The global expansion of Aedes albopictus together with the absence of vaccines for most of the arboviruses transmitted by this mosquito has stimulated the development of sterile-male strategies aiming at controlling disease transmission through the suppression of natural vector populations. In this context, two environmentally friendly control strategies, namely the Sterile Insect Technique (SIT) and the Wolbachia-based Incompatible Insect Technique (IIT) are currently being developed in several laboratories worldwide. So far however, there is a lack of comparative assessment of these strategies under the same controlled conditions. Here, we compared the mating capacities, i.e. insemination capacity, sterilization capacity and mating competitiveness of irradiated (35 Gy) and incompatible Ae. albopictus males at different ages and ratios under laboratory controlled conditions. Our data show that there was no significant difference in insemination capacity of irradiated and incompatible males, both male types showing lower capacities than untreated males at 1 day but recovering full capacity within 5 days following emergence. Regarding mating competitiveness trials, a global observed trend is that incompatible males tend to induce a lower hatching rate than irradiated males in cage controlled confrontations. More specifically, incompatible males were found more competitive than irradiated males in 5:1 ratio regardless of age, while irradiated males were only found more competitive than incompatible males in the 1:1 ratio at 10 days old. Overall, under the tested conditions, IIT seemed to be slightly more effective than SIT. However, considering that a single strategy will likely not be adapted to all environments, our data stimulates the need for comparative assessments of distinct strategies in up-scaled conditions in order to identify the most suitable and safe sterilizing technology to be implemented in a specific environmental setting and to identify the

  11. Global patterns of synchronization in human communications

    PubMed Central

    Vavilala, Vaibhav; Benito, Rosa M.; Bar-Yam, Yaneer

    2017-01-01

    Social media are transforming global communication and coordination and provide unprecedented opportunities for studying socio-technical domains. Here we study global dynamical patterns of communication on Twitter across many scales. Underlying the observed patterns is both the diurnal rotation of the Earth, day and night, and the synchrony required for contingency of actions between individuals. We find that urban areas show a cyclic contraction and expansion that resembles heartbeats linked to social rather than natural cycles. Different urban areas have characteristic signatures of daily collective activities. We show that the differences detected are consistent with a new emergent global synchrony that couples behaviour in distant regions across the world. Although local synchrony is the major force that shapes the collective behaviour in cities, a larger-scale synchronization is beginning to occur. PMID:28250100

  12. On the impacts of computing daily temperatures as the average of the daily minimum and maximum temperatures

    NASA Astrophysics Data System (ADS)

    Villarini, Gabriele; Khouakhi, Abdou; Cunningham, Evan

    2017-12-01

    Daily temperature values are generally computed as the average of the daily minimum and maximum observations, which can lead to biases in the estimation of daily averaged values. This study examines the impacts of these biases on the calculation of climatology and trends in temperature extremes at 409 sites in North America with at least 25 years of complete hourly records. Our results show that the calculation of daily temperature based on the average of minimum and maximum daily readings leads to an overestimation of the daily values of 10+ % when focusing on extremes and values above (below) high (low) thresholds. Moreover, the effects of the data processing method on trend estimation are generally small, even though the use of the daily minimum and maximum readings reduces the power of trend detection ( 5-10% fewer trends detected in comparison with the reference data).

  13. Novel Once-Daily Extended-Release Tacrolimus Versus Twice-Daily Tacrolimus in De Novo Kidney Transplant Recipients: Two-Year Results of Phase 3, Double-Blind, Randomized Trial.

    PubMed

    Rostaing, Lionel; Bunnapradist, Suphamai; Grinyó, Josep M; Ciechanowski, Kazimierz; Denny, Jason E; Silva, Helio Tedesco; Budde, Klemens

    2016-04-01

    1-year data from this trial showed the noninferiority of a novel once-daily extended-release tacrolimus (LCPT; Envarsus XR) to immediate-release tacrolimus (IR-Tac) twice daily after kidney transplantation. Final 24-month analysis of a 2-armed, parallel-group, randomized, double-blind, double-dummy, multicenter, phase 3 trial. 543 de novo kidney recipients randomly assigned to LCPT (n=268) or IR-Tac (n=275); 507 (93.4%) completed the 24-month study. LCPT tablets once daily at 0.17 mg/kg/d or IR-Tac twice daily at 0.1 mg/kg/d; subsequent doses were adjusted to maintain target trough ranges (first 30 days, 6-11 ng/mL; thereafter, 4-11 ng/mL). The intervention was 24 months; the study was double blinded for the entirety. Treatment failure (death, transplant failure, biopsy-proven acute rejection, or loss to follow up) within 24 months. Safety end points included adverse events, serious adverse events, new-onset diabetes, kidney function, opportunistic infections, and malignancies. Pharmacokinetic measures included total daily dose (TDD) of study drugs and tacrolimus trough levels. 24-month treatment failure was LCPT, 23.1%; IR-Tac, 27.3% (treatment difference, -4.14% [95% CI, -11.38% to +3.17%], well below the +10% noninferiority criterion defined for the primary 12-month end point). Subgroup analyses showed fewer treatment failures for LCPT versus IR-Tac among black, older, and female recipients. Safety was similar between groups. From month 1, TDD was lower for LCPT; the difference increased over time. At month 24, mean TDD for LCPT was 24% lower than for the IR-Tac group (P<0.001), but troughs were similar (means at 24 months: LCPT, 5.47 ± 0.17 ng/mL; IR-Tac, 5.8 ± 0.30 ng/mL; P=0.4). Trial participant eligibility criteria may limit the generalizability of results to the global population of de novo kidney transplant recipients. Results suggest that once-daily LCPT in de novo kidney transplantation has comparable efficacy and safety profile to that of IR

  14. A Daily Diary Approach to the Examination of Chronic Stress, Daily Hassles and Safety Perceptions in Hospital Nursing.

    PubMed

    Louch, Gemma; O'Hara, Jane; Gardner, Peter; O'Connor, Daryl B

    2017-12-01

    Stress is a significant concern for individuals and organisations. Few studies have explored stress, burnout and patient safety in hospital nursing on a daily basis at the individual level. This study aimed to examine the effects of chronic stress and daily hassles on safety perceptions, the effect of chronic stress on daily hassles experienced and chronic stress as a potential moderator. Utilising a daily diary design, 83 UK hospital nurses completed three end-of-shift diaries, yielding 324 person days. Hassles, safety perceptions and workplace cognitive failure were measured daily, and a baseline questionnaire included a measure of chronic stress. Hierarchical multivariate linear modelling was used to analyse the data. Higher chronic stress was associated with more daily hassles, poorer perceptions of safety and being less able to practise safely, but not more workplace cognitive failure. Reporting more daily hassles was associated with poorer perceptions of safety, being less able to practise safely and more workplace cognitive failure. Chronic stress did not moderate daily associations. The hassles reported illustrate the wide-ranging hassles nurses experienced. The findings demonstrate, in addition to chronic stress, the importance of daily hassles for nurses' perceptions of safety and the hassles experienced by hospital nurses on a daily basis. Nurses perceive chronic stress and daily hassles to contribute to their perceptions of safety. Measuring the number of daily hassles experienced could proactively highlight when patient safety threats may arise, and as a result, interventions could usefully focus on the management of daily hassles.

  15. Global impact of asthma on children and adolescents' daily lives: the room to breathe survey.

    PubMed

    Wildhaber, Johannes; Carroll, William D; Brand, Paul L P

    2012-04-01

    To establish children and adolescents' perspectives regarding their asthma and its impact upon their daily lives. A 14-item questionnaire. Canada, Greece, Hungary, The Netherlands, the United Kingdom, and South Africa. Children/adolescents (aged 8-15 years) with physician-diagnosed asthma. Interviews were conducted by telephone (Canada, Greece, Hungary, The Netherlands, and the United Kingdom) or face-to-face (South Africa). Asthma symptoms, impact on activities, and quality of life. Of the 943 children/adolescents interviewed, 60% were male. Most (81%) described their asthma as "not too bad" or "I only get it every now and then," with only 4% reporting their asthma as being "very bad"; however, 92% experienced asthma-related coughing and 59% reported nocturnal awakening. Over half (57%) of children/adolescents believed they could predict when their asthma would make them ill; the most common initial symptoms being breathlessness (41%) and bad cough (33%). They considered the worst things about having asthma to be the symptoms of an asthma attack (32%) and not being able to play sport (25%). Almost half (47%) of children/adolescents felt that their asthma affected their ability to play sport or engage in physical activity. One in ten reported they had suffered asthma-related bullying. Children/adolescents underestimate the severity of their asthma, and overestimate its control, indicating that they expect their illness to be symptomatic. Asthma has a substantial impact on their daily lives, particularly on physical activity and social functioning. Efforts are required to improve asthma control and expectations of health in children/adolescents. Copyright © 2011 Wiley Periodicals, Inc.

  16. [Safinamide from daily clinical practice: first clinical steps].

    PubMed

    Pagonabarraga, J; Kulisevsky, J

    2017-11-16

    The management of motor complications in Parkinson's disease (PD) is still limited. Safinamide, a new drug that has MAO-B inhibition and antiglutamatergic effects through inhibition of sodium channels, has shown efficacy for the treatment of fluctuations at doses of 50-100 mg/day. From daily clinical practice, we describe the efficacy and tolerability of safinamide at three months in PD patients with motor complications. Efficacy was assessed by the Clinical Global Impression of Change scale and change in 'off' time during the daytime. All reported adverse events were recorded. Fifty patients were recruited. 57.4% reported to be much better or moderately better at three months, improving both motor and non-motor fluctuations. Significant decrease of 0.9 ± 0.6 h/day was achieved at three months. In 13 patients (27.6%), levodopa equivalent daily dose was reduced in 132 mg/day. In patients with dyskinesias, safinamide 100 mg/day was better for controlling fluctuations and dyskinesias. 19% of patients had mild adverse events. Seven patients stopped treatment after development of confusional syndrome. The dopaminergic and non-dopaminergic action of safinamide exerts a good control of motor fluctuations. In patients with fluctuations and dyskinesias the dose of 100 mg/day of safinamide is preferred. Tolerability was good, except for patients older than 75 years or in advanced stages of the disease.

  17. Depression Among Non-Daily Smokers Compared to Daily Smokers and Never-Smokers in the United States: An Emerging Problem.

    PubMed

    Weinberger, Andrea H; Gbedemah, Misato; Wall, Melanie M; Hasin, Deborah S; Zvolensky, Michael J; Chaiton, Michael; Goodwin, Renee D

    2017-09-01

    Depression is strongly associated with daily smoking. Yet, little is known about the association between depression and non-daily smoking. The aim of this study was to investigate the prevalence of past-year depression and changes in past-year depression over time among non-daily smokers, compared to daily smokers and never-smokers, overall and stratified by age, gender, income, nicotine dependence, and cigarettes per day. Data were drawn from the National Household Survey on Drug Use (NSDUH), an annual cross-sectional study of persons aged 12 and over (total study population N = 496 805). The prevalence of past-year depression was examined annually among non-daily smokers, daily smokers, and never-smokers from 2005 to 2013 using linear trend analyses. Past-year depression was common among 10.10% of non-daily smokers, common among 10.78% of daily smokers, and 5.51% of never-smokers in 2013. The prevalence of depression increased from 2005 to 2013 among non-daily smokers (9.06% vs. 10.10%; p = .034) while there was no significant change in depression over time among daily smokers. Increases in depression among non-daily smokers occurred for both men and women and appear most pronounced youth, those smoking fewer cigarettes, and those without nicotine dependence. The prevalence of depression among non-daily smokers was equivalent to daily smokers and nearly twice that among nonsmokers. Depression appears to be increasing over time in non-daily smokers especially among youth, those who smoke less, and those without nicotine dependence. More work on the mental health of non-daily smokers is needed as this is an increasing and understudied group. This is the first study to investigate changes in the prevalence of depression among non-daily smokers compared to daily smokers and never-smokers over the past decade in a nationally representative sample of the United States. The results suggest an increase in depression among non-daily smokers over time that did not

  18. Modeling Cortisol Daily Rhythms of Family Caregivers of Individuals With Dementia: Daily Stressors and Adult Day Services Use.

    PubMed

    Liu, Yin; Almeida, David M; Rovine, Michael J; Zarit, Steven H

    2018-03-02

    The study examined the typical diurnal cortisol trajectory and its differential associations with an intervention, the adult day services (ADS) use, among a sample of family caregivers who experienced high levels of daily stress. On hundred and sixty-five caregivers of individuals with dementia completed an 8-day diary on daily stressors, positive events, sleep quality, and ADS use. The caregivers also provided five saliva samples on each diary day. Daily cortisol trajectories were modeled as a function of time elapsed since awakening, and three spline growth curve models were fit to the cortisol data. Based on the best-fitting linear spline model, the effect of daily ADS use was examined at both daily and person levels. Covariates included daily experiences and other caregiving characteristics. On ADS days, caregivers had a steeper cortisol awakening response (CAR) slope and a steeper morning decline. ADS use remained significant after controlling for covariates at both daily and person levels. The findings suggested potential biophysiological benefits of daily ADS use for a sample that was under chronic stress and high levels of daily stress.

  19. The selection of light emitting diode irradiation parameters for stimulation of human mesenchymal stem cells proliferation

    NASA Astrophysics Data System (ADS)

    Lewandowski, Rafał; Trafny, ElŻbieta A.; Stepińska, Małgorzata; Gietka, Andrzej; Kotowski, Paweł; Dobrzyńska, Monika; Łapiński, Mariusz P.

    2016-12-01

    Human mesenchymal stem cells (hMSCs) with their vast differentiation potential are very useful for cell-based regenerative medicine. To achieve sufficient numbers of cells for tissue engineering, many different methods have been used to reach the effective increase of cell proliferation. Low-energy red light provided by light emitting diodes (LEDs) have been recently introduced as a method that promoted biomodulation and proliferation of hMSCs in vitro. The purpose of this study was to find the optimum stimulatory dosimetric parameters of LED (630 nm) irradiation on the hMSCs proliferation. The energy density was 2, 3, 4, 10, 20 J/cm2 and the power density used was 7, 17 or 30 mW/cm2. Human MSCs were irradiated with single or triple exposures daily at room temperature and the cell proliferation rate was evaluated during nine days after irradiation. The results showed that after irradiation 4 J/cm2 and 17 mW/cm2 at a single dose the proliferation rate of hMSCs increased on day 5 and 9 (13% and 7%, respectively) when compared to nonirradiated cells. However, triple LED irradiation under the same parameters resulted in the decline in the cell proliferation rate on day 5, but the proliferation rate was at the same level on day 9, when compared with the cell proliferation after irradiation with a single dose. The effect of a single dose irradiation with 4 J/cm2 and 17 mW/cm2 on the proliferation of cells was the highest when the cells were irradiated in phosphate-buffered saline (PBS) instead of MSCGM culture medium.

  20. How Well Can Aerosol Measurements from the Terra Morning Polar Orbiting Satellite Represent the Daily Aerosol Abundance and Properties?

    NASA Technical Reports Server (NTRS)

    Kaufman, Y. J.; Holben, B. N.; Tanre, D.; Slutzker, I.; Eck, T. F.; Smirnov, A.; Einaudi, Franco (Technical Monitor)

    2000-01-01

    The Terra mission, launched at the dawn of 1999, and Aqua mission to be launched soon, will possess innovative measurements of the aerosol daily spatial distribution, distinguish between dust, smoke and regional pollution and measure aerosol radiative forcing of climate. Their polar orbit gives daily global coverage, however measurements are acquired at specific time of the day. To what degree can present measurements from Terra taken between 10:00 and 11:30 AM local time, represent the daily average aerosol forcing of climate? Here we answer this question using 7 years of data from the distributed ground based 50-70 instrument Aerosol Robotic Network (AERONET) This (AERONET) half a million measurement data set shows that Terra aerosol measurements represent the daily average values within 5%. The excellent representation is found for large dust particles or small aerosol particles from Fires or regional pollution and for any range of the optical thickness, a measure of the amount of aerosol in the atmosphere.

  1. Image irradiance distribution in the 3MI wide field of view polarimeter

    NASA Astrophysics Data System (ADS)

    Gabrieli, Riccardo; Bartoli, Alessandro; Maiorano, Michele; Bruno, Umberto; Olivieri, Monica; Calamai, Luciano; Manolis, Ilias; Labate, Demetrio

    2015-09-01

    The Multi-Viewing, Multi-Channel, Multi-Polarisation Imager (3MI) is an imaging radiometer for the ESA/Eumetsat MeteOp-SG programme. Based on the heritage of the POLDER/PARASOL instrument, 3MI is designed to collect global observations of the top-of-atmosphere polarised bi-directional reflectance distribution function in 12 spectral bands, by observing the same target from multiple views using a pushbroom scanning concept. The demanding challenge of the 3MI optical design is represented by the polarisation and image irradiance fall-off (throughput uniformity) requirements. In a generic optical system, the image irradiance fall-off is a function of: target radiance distribution and polarisation, entrance pupil size and optical transmittance variations across the field of view (FOV), distortion and vignetting. In most applications these aspects can be considered as independent; however, when high image irradiance uniformity is required, they have to be considered as linked together. This is particularly true in case of a wide FOV polarimeter as 3MI is. In order to properly account for these aspects, an irradiance fall-off analytical model has been developed in the frame of 3MI Optics Pre-Development (OPD), whose aim is to mitigate any technological risks associated with the 3MI instrument development. It is shown how it is possible to control the image irradiance distribution acting on optical design parameters (e.g. distortion and entrance pupil size variation with FOV). Moreover, the impact of polarisation performances on irradiance fall-off is discussed.

  2. Recent solar extreme ultraviolet irradiance observations and modeling: A review

    NASA Technical Reports Server (NTRS)

    Tobiska, W. Kent

    1993-01-01

    For more than 90 years, solar extreme ultraviolet (EUV) irradiance modeling has progressed from empirical blackbody radiation formulations, through fudge factors, to typically measured irradiances and reference spectra was well as time-dependent empirical models representing continua and line emissions. A summary of recent EUV measurements by five rockets and three satellites during the 1980s is presented along with the major modeling efforts. The most significant reference spectra are reviewed and threee independently derived empirical models are described. These include Hinteregger's 1981 SERF1, Nusinov's 1984 two-component, and Tobiska's 1990/1991/SERF2/EUV91 flux models. They each provide daily full-disk broad spectrum flux values from 2 to 105 nm at 1 AU. All the models depend to one degree or another on the long time series of the Atmosphere Explorer E (AE-E) EUV database. Each model uses ground- and/or space-based proxies to create emissions from solar atmospheric regions. Future challenges in EUV modeling are summarized including the basic requirements of models, the task of incorporating new observations and theory into the models, the task of comparing models with solar-terrestrial data sets, and long-term goals and modeling objectives. By the late 1990s, empirical models will potentially be improved through the use of proposed solar EUV irradiance measurements and images at selected wavelengths that will greatly enhance modeling and predictive capabilities.

  3. Quality assessment of solar UV irradiance measured with array spectroradiometers

    NASA Astrophysics Data System (ADS)

    Egli, Luca; Gröbner, Julian; Hülsen, Gregor; Bachmann, Luciano; Blumthaler, Mario; Dubard, Jimmy; Khazova, Marina; Kift, Richard; Hoogendijk, Kees; Serrano, Antonio; Smedley, Andrew; Vilaplana, José-Manuel

    2016-04-01

    The reliable quantification of ultraviolet (UV) radiation at the earth's surface requires accurate measurements of spectral global solar UV irradiance in order to determine the UV exposure to human skin and to understand long-term trends in this parameter. Array spectroradiometers (ASRMs) are small, light, robust and cost-effective instruments, and are increasingly used for spectral irradiance measurements. Within the European EMRP ENV03 project "Solar UV", new devices, guidelines and characterization methods have been developed to improve solar UV measurements with ASRMs, and support to the end user community has been provided. In order to assess the quality of 14 end user ASRMs, a solar UV intercomparison was held on the measurement platform of the World Radiation Center (PMOD/WRC) in Davos, Switzerland, from 10 to 17 July 2014. The results of the blind intercomparison revealed that ASRMs, currently used for solar UV measurements, show a large variation in the quality of their solar UV measurements. Most of the instruments overestimate the erythema-weighted UV index - in particular at large solar zenith angles - due to stray light contribution in the UV-B range. The spectral analysis of global solar UV irradiance further supported the finding that the uncertainties in the UV-B range are very large due to stray light contribution in this wavelength range. In summary, the UV index may be detected by some commercially available ASRMs within 5 % compared to the world reference spectroradiometer, if well characterized and calibrated, but only for a limited range of solar zenith angles. Generally, the tested instruments are not yet suitable for solar UV measurements for the entire range between 290 and 400 nm under all atmospheric conditions.

  4. Quality assessment of solar UV irradiance measured with array spectroradiometers

    NASA Astrophysics Data System (ADS)

    Egli, L.; Gröbner, J.; Hülsen, G.; Bachmann, L.; Blumthaler, M.; Dubard, J.; Khazova, M.; Kift, R.; Hoogendijk, K.; Serrano, A.; Smedley, A. R. D.; Vilaplana, J.-M.

    2015-12-01

    The reliable quantification of ultraviolet (UV) radiation at the Earth's surface requires accurate measurements of spectral global solar UV irradiance in order to determine the UV exposure to human skin and to understand long-term trends in this parameter. Array spectroradiometers are small, light, robust and cost effective instruments and are increasingly used for spectral irradiance measurements. Within the European EMRP-ENV03 project "Solar UV", new devices, guidelines, and characterization methods have been developed to improve solar UV measurements with array spectroradiometers and support to the end-user community has been provided. In order to assess the quality of 14 end-user array spectroradiometers, a solar UV intercomparison was held on the measurement platform of the World Radiation Center (PMOD/WRC) in Davos, Switzerland, from 10 to 17 July 2014. The results of the intercomparison revealed that array spectroradiometers, currently used for solar UV measurements, show a large variation in the quality of their solar UV measurements. Most of the instruments overestimate the erythema weighted UV index - in particular at low solar zenith angles - due to stray light contribution in the UV-B range. The spectral analysis of global solar UV irradiance further supported the finding that the uncertainties in the UV-B range are very large due to stray light contribution in this wavelength range. In summary, the UV index may be detected by some commercially available array spectroradiometer within 5 % compared to the world reference spectroradiometer, if well characterized and calibrated, but only for a limited range or solar zenith angle. Generally, the tested instruments are not yet suitable for solar UV measurements for the entire range between 290 to 400 nm under all atmospheric conditions.

  5. Quantifying solar spectral irradiance in aquatic habitats for the assessment of photoenhanced toxicity

    USGS Publications Warehouse

    Barron, M.G.; Little, E.E.; Calfee, R.; Diamond, S.

    2000-01-01

    The spectra and intensity of solar radiation (solar spectral irradiance [SSI]) was quantified in selected aquatic habitats in the vicinity of an oil field on the California coast. Solar spectral irradiance measurements consisted of spectral scans (280–700 nm) and radiometric measurements of ultraviolet (UV): UVB (280–320 nm) and UVA (320–400 nm). Solar spectral irradiance measurements were taken at the surface and at various depths in two marsh ponds, a shallow wetland, an estuary lagoon, and the intertidal area of a high-energy sandy beach. Daily fluctuation in SSI showed a general parabolic relationship with time; maximum structure–activity relationship (SAR) was observed at approximate solar noon. Solar spectral irradiance measurements taken at 10-cm depth at approximate solar noon in multiple aquatic habitats exhibited only a twofold variation in visible light and UVA and a 4.5-fold variation in UVB. Visible light ranged from 11,000 to 19,000 μW/cm2, UVA ranged from 460 to 1,100 μW/cm2, and UVB ranged from 8.4 to 38 μW/cm2. In each habitat, the attenuation of light intensity with increasing water depth was differentially affected over specific wavelengths of SSI. The study results allowed the development of environmentally realistic light regimes necessary for photoenhanced toxicity studies.

  6. The effect of premenstrual symptoms on activities of daily life.

    PubMed

    Dennerstein, Lorraine; Lehert, Philippe; Bäckström, Torbjörn Carl; Heinemann, Klaas

    2010-08-01

    To assess impact of premenstrual symptoms on activities of women's daily lives (ADL). Cross-sectional population-based survey. Market research company. A total of 4,085 women aged 14-50 years recruited by random telephone digit dialing in France, Germany, Hungary, Italy, Spain, the United Kingdom, Brazil, and Mexico. None. A telephone interview checklist of 23 premenstrual symptoms, sociodemographic and lifestyle variables, and ADL effects (global question and seven areas). Stepwise regression measured the effect of premenstrual symptoms and sociodemographic factors on ADL. Symptoms and symptom domains (physical and mental) had similar negative effects on ADL. Activities of daily life were predominantly affected by symptom severity. Income level, age, and country also significantly affected ADL. In all, 2,638 women (64.6%) were minimally affected in ADL, 981 (24%) were moderately affected, and 454 (11.1%) were severely affected. Both physical and mental premenstrual symptoms have significant impact on quality of life, assessed as ADL. Up to 35% of women of reproductive age in Europe and Latin America were moderately or severely affected in ADL by cyclical premenstrual symptoms. Copyright (c) 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

  7. Rapid Loss of Bone Mass and Strength in Mice after Abdominal Irradiation

    PubMed Central

    Jia, Dan; Gaddy, Dana; Suva, Larry J.; Corry, Peter M.

    2011-01-01

    Localized irradiation is a common treatment modality for malignancies in the pelvic-abdominal cavity. We report here on the changes in bone mass and strength in mice 7–14 days after abdominal irradiation. Male C57BL/6 mice of 10–12 weeks of age were given a single-dose (0, 5, 10, 15 or 20 Gy) or fractionated (3 Gy × 2 per day × 7.5 days) X rays to the abdomen and monitored daily for up to 14 days. A decrease in the serum bone formation marker and ex vivo osteoblast differentiation was detected 7 days after a single dose of radiation, with little change in the serum bone resorption marker and ex vivo osteoclast formation. A single dose of radiation elicited a loss of bone mineral density (BMD) within 14 days of irradiation. The BMD loss was up to 4.1% in the whole skeleton, 7.3% in tibia, and 7.7% in the femur. Fractionated abdominal irradiation induced similar extents of BMD loss 10 days after the last fraction: 6.2% in the whole skeleton, 5.1% in tibia, and 13.8% in the femur. The loss of BMD was dependent on radiation dose and was more profound in the trabecula-rich regions of the long bones. Moreover, BMD loss in the total skeleton and the femurs progressed with time. Peak load and stiffness in the mid-shaft tibia from irradiated mice were 11.2–14.2% and 11.5–25.0% lower, respectively, than sham controls tested 7 days after a single-dose abdominal irradiation. Our data demonstrate that abdominal irradiation induces a rapid loss of BMD in the mouse skeleton. These effects are bone type- and region-specific but are independent of radiation fractionation. The radiation-induced abscopal damage to the skeleton is manifested by the deterioration of biomechanical properties of the affected bone. PMID:21859327

  8. Potential Beneficial Effects of Si-Wu-Tang on White Blood Cell Numbers and the Gastrointestinal Tract of γ-Ray Irradiated Mice

    PubMed Central

    Ni, Jin; Romero-Weaver, Ana L.; Kennedy, Ann R.

    2014-01-01

    Si-Wu-Tang (SWT) is a decoction consisting of a mixture of ingredients of Rehmanniae Radix, Angelica Radix, Chuanxiong Rhizoma and Paeoniae Radix. As a traditional Chinese herbal decoction, SWT has been widely used for the treatment of diseases characterized as blood and/or energy deficit. The present study was performed to evaluate the effects of SWT on the different populations of circulating white blood cells (WBCs) and gastrointestinal changes in γ-ray irradiated mice. Female mice were treated daily with orally administered SWT seven days before irradiation, until one day before irradiation or until one day before sample collection. WBC counts were determined from peripheral blood samples taken from the mice at different times post-irradiation. Hematoxylin and eosin (H&E) staining, as well as immunohistochemical analysis of fibrinogen, were utilized to evaluate the effects of SWT in the intestines of mice after radiation exposure. The results of the present studies demonstrate that SWT has protective effects against radiation damage to circulating WBCs, specifically to lymphocytes, and to the gastrointestinal tract of the irradiated animals. PMID:25324699

  9. Development of a Global Fire Weather Database

    NASA Technical Reports Server (NTRS)

    Field, R. D.; Spessa, A. C.; Aziz, N. A.; Camia, A.; Cantin, A.; Carr, R.; de Groot, W. J.; Dowdy, A. J.; Flannigan, M. D.; Manomaiphiboon, K.; hide

    2015-01-01

    The Canadian Forest Fire Weather Index (FWI) System is the mostly widely used fire danger rating system in the world. We have developed a global database of daily FWI System calculations, beginning in 1980, called the Global Fire WEather Database (GFWED) gridded to a spatial resolution of 0.5 latitude by 2/3 longitude. Input weather data were obtained from the NASA Modern Era Retrospective- Analysis for Research and Applications (MERRA), and two different estimates of daily precipitation from rain gauges over land. FWI System Drought Code calculations from the gridded data sets were compared to calculations from individual weather station data for a representative set of 48 stations in North, Central and South America, Europe, Russia, Southeast Asia and Australia. Agreement between gridded calculations and the station-based calculations tended to be most different at low latitudes for strictly MERRA based calculations. Strong biases could be seen in either direction: MERRA DC over the Mato Grosso in Brazil reached unrealistically high values exceeding DCD1500 during the dry season but was too low over Southeast Asia during the dry season. These biases are consistent with those previously identified in MERRA's precipitation, and they reinforce the need to consider alternative sources of precipitation data. GFWED can be used for analyzing historical relationships between fire weather and fire activity at continental and global scales, in identifying large-scale atmosphere-ocean controls on fire weather, and calibration of FWI-based fire prediction models.

  10. Introducing GFWED: The Global Fire Weather Database

    NASA Technical Reports Server (NTRS)

    Field, R. D.; Spessa, A. C.; Aziz, N. A.; Camia, A.; Cantin, A.; Carr, R.; de Groot, W. J.; Dowdy, A. J.; Flannigan, M. D.; Manomaiphiboon, K.; hide

    2015-01-01

    The Canadian Forest Fire Weather Index (FWI) System is the mostly widely used fire danger rating system in the world. We have developed a global database of daily FWI System calculations, beginning in 1980, called the Global Fire WEather Database (GFWED) gridded to a spatial resolution of 0.5 latitude by 2-3 longitude. Input weather data were obtained from the NASA Modern Era Retrospective-Analysis for Research and Applications (MERRA), and two different estimates of daily precipitation from rain gauges over land. FWI System Drought Code calculations from the gridded data sets were compared to calculations from individual weather station data for a representative set of 48 stations in North, Central and South America, Europe, Russia,Southeast Asia and Australia. Agreement between gridded calculations and the station-based calculations tended to be most different at low latitudes for strictly MERRA based calculations. Strong biases could be seen in either direction: MERRA DC over the Mato Grosso in Brazil reached unrealistically high values exceeding DCD1500 during the dry season but was too low over Southeast Asia during the dry season. These biases are consistent with those previously identified in MERRAs precipitation, and they reinforce the need to consider alternative sources of precipitation data. GFWED can be used for analyzing historical relationships between fire weather and fire activity at continental and global scales, in identifying large-scale atmosphereocean controls on fire weather, and calibration of FWI-based fire prediction models.

  11. Solar influences on global change

    NASA Technical Reports Server (NTRS)

    1994-01-01

    Monitoring of the Sun and the Earth has yielded new knowledge essential to this debate. There is now no doubt that the total radiative energy from the Sun that heats the Earth's surface changes over decadal time scales as a consequence of solar activity. Observations indicate as well that changes in ultraviolet radiation and energetic particles from the Sun, also connected with the solar activity, modulate the layer of ozone that protects the biosphere from the solar ultraviolet radiation. This report reassesses solar influences on global change in the light of this new knowledge of solar and atmospheric variability. Moreover, the report considers climate change to be encompassed within the broader concept of global change; thus the biosphere is recognized to be part of a larger, coupled Earth system. Implementing a program to continuously monitor solar irradiance over the next several decades will provide the opportunity to estimate solar influences on global change, assuming continued maintenance of observations of climate and other potential forcing mechanisms. In the lower atmosphere, an increase in solar radiation is expected to cause global warming. In the stratosphere, however, the two effects produce temperature changes of opposite sign. A monitoring program that would augment long term observations of tropospheric parameters with similar observations of stratospheric parameters could separate these diverse climate perturbations and perhaps isolate a greenhouse footprint of climate change. Monitoring global change in the troposphere is a key element of all facets of the United States Global Change Research Program (USGCRP), not just of the study of solar influences on global change. The need for monitoring the stratosphere is also important for global change research in its own right because of the stratospheric ozone layer.

  12. Intra-oral administration of rebamipide liquid prevents tongue injuries induced by X-ray irradiation in rats.

    PubMed

    Nakashima, Takako; Uematsu, Naoya; Sakurai, Kazushi

    2017-07-01

    Oral mucositis is a common and serious side effect in patients who undergo cytotoxic cancer therapies. The purpose of this study was to investigate the preventive effects of rebamipide on radiation-induced glossitis model in rats. Glossitis was induced by a single dose of 15 Gy of X-rays to the snouts of rats (day 0). A novel form of rebamipide liquid comprising its submicronized crystals was administered intra-orally. The preventive effect of rebamipide on tongue injuries was macroscopically evaluated on day 7 following irradiation. The pretreatment period, dosing frequency, and dose dependency of rebamipide were examined. Two percent rebamipide liquid, administered six times a day for 14 days from day -7 to day 6, significantly decreased the ulcer-like area. However, no significant effect was observed when rebamipide was given either from day -4 or from day -1. Four or six times daily, 2% rebamipide liquid significantly inhibited the ulcer-like injury area ratio, but not when given twice daily. Rebamipide liquid, 1, 2, and 4% six times daily significantly reduced the area ratios of total injury and ulcer-like injury in a dose-dependent manner. Gene expression and protein levels of proinflammatory cytokines and chemokines were dramatically elevated in the irradiated tongues of control rats on day 7 without rebamipide liquid treatment. They were dose-dependently and significantly suppressed in rebamipide-treated groups. Intra-oral administration of rebamipide liquid prevented oral mucositis dose-dependently accompanied by the suppression of inflammatory expression in the radiation-induced rats' glossitis model.

  13. Image-guided total-marrow irradiation using helical tomotherapy in patients with multiple myeloma and acute leukemia undergoing hematopoietic cell transplantation.

    PubMed

    Wong, Jeffrey Y C; Rosenthal, Joseph; Liu, An; Schultheiss, Timothy; Forman, Stephen; Somlo, George

    2009-01-01

    Total-body irradiation (TBI) has an important role in patients undergoing hematopoietic cell transplantation (HCT), but is associated with significant toxicities. Targeted TBI using helical tomotherapy results in reduced doses to normal organs, which predicts for reduced toxicities compared with standard TBI. Thirteen patients with multiple myeloma were treated in an autologous tandem transplantation Phase I trial with high-dose melphalan, followed 6 weeks later by total-marrow irradiation (TMI) to skeletal bone. Dose levels were 10, 12, 14, and 16 Gy at 2 Gy daily/twice daily. In a separate allogeneic HCT trial, 8 patients (5 with acute myelogenous leukemia, 1 with acute lymphoblastic leukemia, 1 with non-Hodgkin's lymphoma, and 1 with multiple myeloma) were treated with TMI plus total lymphoid irradiation plus splenic radiotherapy to 12 Gy (1.5 Gy twice daily) combined with fludarabine/melphalan. For the 13 patients in the tandem autologous HCT trial, median age was 54 years (range, 42-66 years). Median organ doses were 15-65% that of the gross target volume dose. Primarily Grades 1-2 acute toxicities were observed. Six patients reported no vomiting; 9 patients, no mucositis; 6 patients, no fatigue; and 8 patients, no diarrhea. For the 8 patients in the allogeneic HCT trial, median age was 52 years (range, 24-61 years). Grades 2-3 nausea, vomiting, mucositis, and diarrhea were observed. In both trials, no Grade 4 nonhematologic toxicity was observed, and all patients underwent successful engraftment. This study shows that TMI using helical tomotherapy is clinically feasible. The reduced acute toxicities observed compare favorably with those seen with standard TBI. Initial results are encouraging and warrant further evaluation as a method to dose escalate with acceptable toxicity or to offer TBI-containing regimens to patients unable to tolerate standard approaches.

  14. Global patterns of synchronization in human communications.

    PubMed

    Morales, Alfredo J; Vavilala, Vaibhav; Benito, Rosa M; Bar-Yam, Yaneer

    2017-03-01

    Social media are transforming global communication and coordination and provide unprecedented opportunities for studying socio-technical domains. Here we study global dynamical patterns of communication on Twitter across many scales. Underlying the observed patterns is both the diurnal rotation of the Earth, day and night, and the synchrony required for contingency of actions between individuals. We find that urban areas show a cyclic contraction and expansion that resembles heartbeats linked to social rather than natural cycles. Different urban areas have characteristic signatures of daily collective activities. We show that the differences detected are consistent with a new emergent global synchrony that couples behaviour in distant regions across the world. Although local synchrony is the major force that shapes the collective behaviour in cities, a larger-scale synchronization is beginning to occur. © 2017 The Author(s).

  15. Effects of low intensity laser acupoint irradiation on inhibiting islet beta-cell apoptosis in rats with type 2 diabetes

    NASA Astrophysics Data System (ADS)

    Xiong, Guoxin; Xiong, Leilei; Li, Xinzhong

    2016-09-01

    To investigate the effects of low intensity semiconductor laser acupoint irradiation on inhibiting islet beta-cell apoptosis in rats with type 2 diabetes, a method using a high-fat diet and low-dose intraperitoneal injections of streptozotocin established a type 2 diabetes mellitus rat model. Model rats were randomly divided into a laser acupoint irradiation group, rosiglitazone control group, and placebo group; each group had 10 rats. In addition, 10 normal male rats were selected for the normal control group. The Housanli, Neiting and Yishu acupoints of the rats in the laser acupoint irradiation group were irradiated with a 10 mW semiconductor laser; each point was irradiated for 15 min, once every 2 d over 28 d, for a total of 14 episodes of irradiation. The rosiglitazone group rats were given rosiglitazone (0.2 mg kg-1) intragastrically; the placebo group rats were given 0.9% brine (0.2 mg kg-1) intragastrically, once daily, for four consecutive weeks. The change of fasting blood glucose was determined before and after each treatment. The islet beta-cell apoptosis was determined. The islet beta-cell apoptosis rates of the laser acupoint irradiation group and the rosiglitazone group were significantly lower than the rate of the placebo group. Even though the rate was lower in the laser acupoint irradiation group than in the rosiglitazone group, there was no significant difference between them. It is shown that acupoint irradiation with a semiconductor laser can effectively inhibit islet beta-cell apoptosis in rats with type 2 diabetes.

  16. Spring snow albedo feedback in daily data over Russia: Comparing in-situ measurements with reanalysis products.

    NASA Astrophysics Data System (ADS)

    Wegmann, M.; Zolina, O.; Jacobi, H. W.

    2016-12-01

    Global warming is enhanced at high northern latitudes where the Arctic surface air temperature has risen at twice the rate of the global average in recent decades - a feature called Arctic amplification. This recent Arctic warming signal likely results from several factors such as the albedo feedback due to a diminishing cryosphere, enhanced poleward atmospheric and oceanic heat transport, and changes in humidity. Surface albedo feedback is stating that the additional amount of shortwave radiation at the top of the atmosphere decreases with decreasing surface albedo whereas surface air temperature increases with decreasing surface albedo. It is considered a positive feedback in that an initial warming perturbation than kicks off a strengthening warming. Looking at the Northern Hemisphere with its large landmasses, snow albedo feedback is especially strong since most of these landmasses experience snow cover during boreal wintertime. Unfortunately, so far there remains a lack of reliable observational data over large parts of the cryosphere. Satellite products cover large parts of the NH, however lack high temporal resolution and have problems with large solar zenith angles as well as over complex terrain (eg. Wang et al. 2014). Our analysis focuses at the Russian territory where we utilize in-situ radiation and snow depth measurements. We found 50 stations which measure both variables on a daily basis for the period 2000-2013. Since Hall (2004) found that 50% of the notal NH snow albedo feedback caused by global warming occurs during NH spring, we focus on the transition period of March to June (MAMJ). Thackeray & Fletcher 2006 compared albedo feedback processes CMIP3 and CMIP5 model families and found while the models represent the feedback process accurately, there are still inherent biases and outdated parameterizations. Therefore we use the daily observations and state of the art reanalysis products to 1) evaluate reanalysis and model products in respect to

  17. Tissue irradiator

    DOEpatents

    Hungate, F.P.; Riemath, W.F.; Bunnell, L.R.

    1975-12-16

    A tissue irradiator is provided for the in-vivo irradiation of body tissue. The irradiator comprises a radiation source material contained and completely encapsulated within vitreous carbon. An embodiment for use as an in- vivo blood irradiator comprises a cylindrical body having an axial bore therethrough. A radioisotope is contained within a first portion of vitreous carbon cylindrically surrounding the axial bore, and a containment portion of vitreous carbon surrounds the radioisotope containing portion, the two portions of vitreous carbon being integrally formed as a single unit. Connecting means are provided at each end of the cylindrical body to permit connections to blood- carrying vessels and to provide for passage of blood through the bore. In a preferred embodiment, the radioisotope is thulium-170 which is present in the irradiator in the form of thulium oxide. A method of producing the preferred blood irradiator is also provided, whereby nonradioactive thulium-169 is dispersed within a polyfurfuryl alcohol resin which is carbonized and fired to form the integral vitreous carbon body and the device is activated by neutron bombardment of the thulium-169 to produce the beta-emitting thulium-170.

  18. Modelling total solar irradiance since 1878 from simulated magnetograms

    NASA Astrophysics Data System (ADS)

    Dasi-Espuig, M.; Jiang, J.; Krivova, N. A.; Solanki, S. K.

    2014-10-01

    Aims: We present a new model of total solar irradiance (TSI) based on magnetograms simulated with a surface flux transport model (SFTM) and the Spectral And Total Irradiance REconstructions (SATIRE) model. Our model provides daily maps of the distribution of the photospheric field and the TSI starting from 1878. Methods: The modelling is done in two main steps. We first calculate the magnetic flux on the solar surface emerging in active and ephemeral regions. The evolution of the magnetic flux in active regions (sunspots and faculae) is computed using a surface flux transport model fed with the observed record of sunspot group areas and positions. The magnetic flux in ephemeral regions is treated separately using the concept of overlapping cycles. We then use a version of the SATIRE model to compute the TSI. The area coverage and the distribution of different magnetic features as a function of time, which are required by SATIRE, are extracted from the simulated magnetograms and the modelled ephemeral region magnetic flux. Previously computed intensity spectra of the various types of magnetic features are employed. Results: Our model reproduces the PMOD composite of TSI measurements starting from 1978 at daily and rotational timescales more accurately than the previous version of the SATIRE model computing TSI over this period of time. The simulated magnetograms provide a more realistic representation of the evolution of the magnetic field on the photosphere and also allow us to make use of information on the spatial distribution of the magnetic fields before the times when observed magnetograms were available. We find that the secular increase in TSI since 1878 is fairly stable to modifications of the treatment of the ephemeral region magnetic flux.

  19. Enhanced susceptibility of irradiated tumor vessels to vascular endothelial growth factor receptor tyrosine kinase inhibition.

    PubMed

    Zips, Daniel; Eicheler, Wolfgang; Geyer, Peter; Hessel, Franziska; Dörfler, Annegret; Thames, Howard D; Haberey, Martin; Baumann, Michael

    2005-06-15

    Previous experiments with PTK787/ZK222584, a specific inhibitor of vascular endothelial growth factor receptor (VEGFR) tyrosine kinases, using irradiated human FaDu squamous cell carcinoma in nude mice, suggested that radiation-damaged tumor vessels are more sensitive to VEGFR inhibition. To test this hypothesis, the tumor transplantation site (i.e., the right hind leg of nude mice) was irradiated 10 days before transplantation of FaDu to induce radiation damage in the host tissue. FaDu tumors vascularized by radiation-damaged blood vessels appeared later, grew at a slower rate, and showed more necrosis and a smaller vessel area per central tumor section than controls. PTK787/ZK222584 at a daily dose of 50 mg/kg body weight had no impact on growth of control tumors. In contrast, tumors vascularized by radiation-damaged vessels responded to PTK787/ZK222584 with longer latency and slower growth rate than controls, and a trend toward further increase in necrosis, indicating that irradiated tumor vessels are more susceptible to VEGFR inhibition than unirradiated vessels. Although not proving causality, expression analysis of VEGF and VEGFR2 shows that enhanced sensitivity of irradiated vessels to a specific inhibitor of VEGFR tyrosine kinases correlates with increased expression of the molecular target.

  20. Global-scale assessment and combination of SMAP with ASCAT (Active) and AMSR2 (Passive) soil moisture products

    USDA-ARS?s Scientific Manuscript database

    Global-scale surface soil moisture (SSM) products retrieved from active and passive microwave remote sensing provide an effective method for monitoring near-real-time SSM content with nearly daily temporal resolution. In the present study, we first inter-compared global-scale error patterns and comb...

  1. Analysis of spatial patterns underlying the linkage between solar irradiance and near-surface air temperatures

    NASA Astrophysics Data System (ADS)

    Balling, Robert C.; Roy, Shouraseni Sen

    2005-06-01

    Many scientists have noted that global temperature anomalies were highly correlated with solar irradiance values until sometime in the 1970s, but since that time, the pronounced warming in the near-surface temperature record is not explained by variations or trends in solar receipt. In this investigation, spatial dimensions are explored in the relationship between irradiance and near-surface air temperatures. At the scale of individual 5° by 5° grid cells, the solar control on annual temperature variations is not statistically significant. When the temperature data are aggregated by 5° latitudinal bands, the solar - temperature connect is generally significant, and in every band, there is substantial evidence that a non-solar control has become dominant in recent decades. The buildup of greenhouse gases and/or some other global-scale feedback, such as widespread changes in atmospheric water vapor, emerge as potential explanations for the recent residual warming found in all latitudinal bands.

  2. Mastering social and organization goals: strategy use by two children with Asperger syndrome during cognitive orientation to daily occupational performance.

    PubMed

    Rodger, Sylvia; Vishram, Alysha

    2010-11-01

    Preliminary data supports the effectiveness of Cognitive Orientation to (daily) Occupational Performance (CO-OP) for children with Asperger syndrome (AS). Children with AS often experience social and organizational difficulties spanning daily occupations. This case study explored the pattern of Global Strategies and Domain-Specific Strategies (DSS) use, the type of guidance, and dimensions of time on task used by two children with AS (aged 10 and 12 years) in addressing social and organizational goals during the CO-OP intervention. Coding of the videotaped CO-OP sessions suggested that both children (a) utilized all the Global strategies, particularly "understanding the context” and "plan"; (b) used six common DSS, namely transitional supports, affective supports, attending, task-specification, task modification, and supplementing task knowledge, with task-specification being most prominent; (c) required minimal guidance while "doing"; and (d) engaged in considerable time "talking about the task.” The results provide initial insights into strategies that may enable children with AS to achieve social and organizational goals.

  3. Analytical Assessment of the Relationship between 100MWp Large-scale Grid-connected Photovoltaic Plant Performance and Meteorological Parameters

    NASA Astrophysics Data System (ADS)

    Sheng, Jie; Zhu, Qiaoming; Cao, Shijie; You, Yang

    2017-05-01

    This paper helps in study of the relationship between the photovoltaic power generation of large scale “fishing and PV complementary” grid-tied photovoltaic system and meteorological parameters, with multi-time scale power data from the photovoltaic power station and meteorological data over the same period of a whole year. The result indicates that, the PV power generation has the most significant correlation with global solar irradiation, followed by diurnal temperature range, sunshine hours, daily maximum temperature and daily average temperature. In different months, the maximum monthly average power generation appears in August, which related to the more global solar irradiation and longer sunshine hours in this month. However, the maximum daily average power generation appears in October, this is due to the drop in temperature brings about the improvement of the efficiency of PV panels. Through the contrast of monthly average performance ratio (PR) and monthly average temperature, it is shown that, the larger values of monthly average PR appears in April and October, while it is smaller in summer with higher temperature. The results concluded that temperature has a great influence on the performance ratio of large scale grid-tied PV power system, and it is important to adopt effective measures to decrease the temperature of PV plant properly.

  4. The Combined Effects of Daily Stressors and Major Life Events on Daily Subjective Ages.

    PubMed

    Bellingtier, Jennifer A; Neupert, Shevaun D; Kotter-Grühn, Dana

    2017-07-01

    Stressors may be a contributing factor in determining how old an individual feels, looks, or would like to be. Currently, little research has been devoted to understanding the relationship between stressors and subjective age in older adults. We focus on the combined impact of major life-event stressors and daily stressors on multiple indicators of subjective age: felt age, ideal age, and look age. Furthermore, we examine the process by which daily stressors relate to subjective ages by testing whether positive affect, control, and negative affect mediate this relationship. Using a daily-diary design, the current study measured older adults' (60-96 years old) stressors, subjective ages, personal control, and affect. Felt, ideal, and look ages each demonstrated a unique pattern of interactions between daily stressors and major life-event stressors. Furthermore, our findings suggest that on the daily level, the relationship between stressors and felt age is mediated by negative affect but not by control and positive affect. Findings indicate the need to consider the broader contextual picture of stressors, as well as their differential impact on multiple indicators of subjective age. © The Author 2015. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  5. Automated semi-spherical irradiance meter

    NASA Astrophysics Data System (ADS)

    Tecpoyotl-Torres, M.; Vera-Dimas, J. G.; Escobedo-Alatorre, J.; Cabello-Ruiz, R.; Varona, J.

    2011-09-01

    In this semi-spherical meter, a single detector is used to realize all measurements, which is located on the extreme of a rectangular ring (assumed as joined two mobile branches in order to compensate the weights), describing half-meridians from 0° up to 170°. The illumination source under test is located at the center of the mobile support, which can rotate 360° horizontally. The two combined movements allow us to obtain a semi-spherical geometry. The number of measurement points is determined by the two step-motors located under the mobile support of the luminary and on one of the two fixed arms, which support the mobile rectangular ring, respectively. The mechanical arrangement has the enough rigidity to support the precision required for the acquisition stage, based on a dsPIC. The main advantages of this arrange are: Its low costs (using recyclable materials only such as "electronic waste"), a reliable detection based on a single photo-detector, with an integrated amplification stage, and the mechanical design. The received power by the detector is useful to obtain the irradiance profile of the lighting sources under test. The semi-spherical geometry of the meter makes it useful for the analysis of directive and non directive sources, in accordance with the angle described by the mobile ring. In this work, special attention is given to LED lamps due to its impact in several sceneries of the daily life. A comparison between the irradiance patterns of two LED lamps is also given.

  6. The Daily Practices of Successful Principals

    ERIC Educational Resources Information Center

    Brock, Barbara L.; Grady, Marilyn L.

    2011-01-01

    While many books outline the attributes of successful school leaders, few describe how those traits manifest in daily practice. "The Daily Practices of Successful Principals" goes beyond the outward picture of excellence and provides a compendium of daily practices used by successful principals in various settings. Written by former administrators…

  7. Comparison of twice-daily vs once-daily deferasirox dosing in a gerbil model of iron cardiomyopathy

    PubMed Central

    Otto-Duessel, Maya; Aguilar, Michelle; Nick, Hanspeter; Moats, Rex; Wood, John C.

    2010-01-01

    Objective Despite the availability of deferoxamine chelation therapy for more than 20 years, iron cardiomyopathy remains the leading cause of death in thalassemia major patients. Effective chelation of cardiac iron is difficult; cardiac iron stores respond more slowly to chelation therapy and require a constant gradient of labile iron species between serum and myocytes. We have previously demonstrated the efficacy of once-daily deferasirox in removing previously stored cardiac iron in the gerbil, but changes in cardiac iron were relatively modest compared with hepatic iron. We postulated that daily divided dosing, by sustaining a longer labile iron gradient from myocytes to serum, would produce better cardiac iron chelation than a comparable daily dose. Methods Twenty-four 8- to 10-week-old female gerbils underwent iron dextran—loading for 10 weeks, followed by a 1-week iron equilibration period. Animals were divided into three treatment groups of eight animals each and were treated with deferasirox 100 mg/kg/day as a single dose, deferasirox 100 mg/kg/day daily divided dose, or sham chelation for a total of 12 weeks. Following euthanasia, organs were harvested for quantitative iron and tissue histology. Results Hepatic and cardiac iron contents were not statistically different between the daily single-dose and daily divided-dose groups. However, the ratio of cardiac to hepatic iron content was lower in the divided-dose group (0.78% vs 1.11%, p = 0.0007). Conclusion Daily divided dosing of deferasirox changes the relative cardiac and liver iron chelation profile compared with daily single dosing, trading improvements in cardiac iron elimination for less-effective hepatic chelation. PMID:17588475

  8. cMOOCs and Global Learning: An Authentic Alternative

    ERIC Educational Resources Information Center

    Yeager, Carol; Hurley-Dasgupta, Betty; Bliss, Catherine A.

    2013-01-01

    Massive open online courses (MOOCs) continue to attract press coverage as they change almost daily in their format, number of registrations, and potential for credentialing. An enticing aspect of the MOOC is its global reach. In this paper, we will focus on a type of MOOC called a cMOOC because it is based on the theory of connectivism and fits…

  9. In vitro analysis of low-level laser irradiation on human osteoblast-like cells proliferation

    NASA Astrophysics Data System (ADS)

    Bloise, Nora; Saino, Enrica; Bragheri, Francesca; Minzioni, Paolo; Cristiani, Ilaria; Imbriani, Marcello; Visai, Livia

    2011-07-01

    The objective of this study was to examine the in vitro effect of a single or a multiple doses of low-level laser irradiation (LLLI) on proliferation of the human osteosarcoma cell line, SAOS-2. SAOS-2 cells were divided in five groups and exposed to LLLI (659 nm diode laser; 11 mW power output): group I as a control (dark), group II exposed to a single laser dose of 1 J/cm2, group III irradiated with a single dose of 3 J/cm2, and group IV and V exposed for three consecutive days to 1 or 3 J/cm², respectively. Cellular proliferation was assessed daily up to 7 days of culturing. The obtained results showed an increase in proliferative capacity of SAOS-2 cells during the first 96 h of culturing time in once-irradiated cells, as compared to control cells. Furthermore, a significantly higher proliferation in the group IV and V was detected if compared to a single dose or to control group after 96 h and 7 days. In conclusion, the effect of the single dose on cell proliferation was transitory and repeated irradiations were necessary to observe a strong enhancement of SAOS-2 growth. As a future perspective, we would like to determine the potential of LLLI as a new approach for promoting bone regeneration onto biomaterials.

  10. Incidence of deep vein thrombosis is increased with 30 mg twice daily dosing of enoxaparin compared with 40 mg daily.

    PubMed

    Riha, Gordon M; Van, Philbert Y; Differding, Jerome A; Schreiber, Martin A

    2012-05-01

    The purpose of this study was to analyze whether 2 standard dosing regimens of enoxaparin (30 mg twice daily vs 40 mg once daily) would result in different deep vein thrombosis (DVT) rates and anti-factor Xa activity (anti-Xa) in surgical patients. Patients who required enoxaparin for prophylaxis were followed prospectively. Demographics were recorded. Patients underwent standardized duplex screening. Peak anti-Xa levels were drawn on 4 consecutive days. Sixty-three patients were followed up (28 patients on 30 mg twice daily, 35 patients on 40 mg once daily). There was no significant difference in demographics between groups. Twenty-five percent of patients on 30 mg twice daily developed a DVT, whereas 2.9% of patients on 40 mg once daily developed a DVT. Patients on 30 mg twice daily had significantly lower anti-Xa levels. The incidence of DVT is increased in surgical patients who receive 30 mg twice daily dosing of enoxaparin compared with 40 mg daily. Dosing of 40 mg once daily results in significantly higher peak anti-Xa levels compared with 30 mg twice daily. Copyright © 2012 Elsevier Inc. All rights reserved.

  11. Global Warming And Meltwater

    NASA Astrophysics Data System (ADS)

    Bratu, S.

    2012-04-01

    In order to find new approaches and new ideas for my students to appreciate the importance of science in their daily life, I proposed a theme for them to debate. They had to search for global warming information and illustrations in the media, and discuss the articles they found in the classroom. This task inspired them to search for new information about this important and timely theme in science. I informed my students that all the best information about global warming and meltwater they found would be used in a poster that would help us to update the knowledge base of the Physics laboratory. I guided them to choose the most eloquent images and significant information. Searching and working to create this poster, the students arrived to better appreciate the importance of science in their daily life and to critically evaluate scientific information transmitted via the media. In the poster we created, one can find images, photos and diagrams and some interesting information: Global warming refers to the rising average temperature of the Earth's atmosphere and oceans and its projected evolution. In the last 100 years, the Earth's average surface temperature increased by about 0.8 °C with about two thirds of the increase occurring over just the last three decades. Warming of the climate system is unequivocal, and scientists are more than 90% certain most of it is caused by increasing concentrations of greenhouse gases produced by human activities such as deforestation and burning fossil fuel. They indicate that during the 21st century the global surface temperature is likely to rise a further 1.1 to 2.9 °C for the lowest emissions scenario and 2.4 to 6.4 °C for the highest predictions. An increase in global temperature will cause sea levels to rise and will change the amount and pattern of precipitation, and potentially result in expansion of subtropical deserts. Warming is expected to be strongest in the Arctic and would be associated with continuing decrease of

  12. Variability in daily, zonal mean lower-stratospheric temperatures

    NASA Technical Reports Server (NTRS)

    Christy, John R.; Drouilhet, S. James, Jr.

    1994-01-01

    Satellite data from the microwave sounding unit (MSU) channel 4, when carefully merged, provide daily zonal anomalies of lower-stratosphere temperature with a level of precision between 0.01 and 0.08 C per 2.5 deg latitude band. Global averages of these daily zonal anomalies reveal the prominent warming events due to volcanic aerosol in 1982 (El Chichon) and 1991 (Mt. Pinatubo), which are on the order of 1 C. The quasibiennial oscillation (QBO) may be extracted from these zonal data by applying a spatial filter between 15 deg N and 15 deg S latitude, which resembles the meridional curvature. Previously published relationships between the QBO and the north polar stratospheric temperatures during northern winter are examined but were not found to be reproduced in the MSU4 data. Sudden stratospheric warmings in the north polar region are represented in the MSU4 data for latitudes poleward of 70 deg N. In the Southern Hemisphere, there appears to be a moderate relationship between total ozone concentration and MSU4 temperatures, though it has been less apparent in 1991 and 1992. In terms of empirical modes of variability, the authors find a strong tendency in EOF 1 (39.2% of the variance) for anomalies in the Northern Hemisphere polar regions to be counterbalanced by anomalies equatorward of 40 deg N and 40 deg S latitudes. In addition, most of the modes revealed significant power in the 15-20 day period band.

  13. Modelling of Sub-daily Hydrological Processes Using Daily Time-Step Models: A Distribution Function Approach to Temporal Scaling

    NASA Astrophysics Data System (ADS)

    Kandel, D. D.; Western, A. W.; Grayson, R. B.

    2004-12-01

    Mismatches in scale between the fundamental processes, the model and supporting data are a major limitation in hydrologic modelling. Surface runoff generation via infiltration excess and the process of soil erosion are fundamentally short time-scale phenomena and their average behaviour is mostly determined by the short time-scale peak intensities of rainfall. Ideally, these processes should be simulated using time-steps of the order of minutes to appropriately resolve the effect of rainfall intensity variations. However, sub-daily data support is often inadequate and the processes are usually simulated by calibrating daily (or even coarser) time-step models. Generally process descriptions are not modified but rather effective parameter values are used to account for the effect of temporal lumping, assuming that the effect of the scale mismatch can be counterbalanced by tuning the parameter values at the model time-step of interest. Often this results in parameter values that are difficult to interpret physically. A similar approach is often taken spatially. This is problematic as these processes generally operate or interact non-linearly. This indicates a need for better techniques to simulate sub-daily processes using daily time-step models while still using widely available daily information. A new method applicable to many rainfall-runoff-erosion models is presented. The method is based on temporal scaling using statistical distributions of rainfall intensity to represent sub-daily intensity variations in a daily time-step model. This allows the effect of short time-scale nonlinear processes to be captured while modelling at a daily time-step, which is often attractive due to the wide availability of daily forcing data. The approach relies on characterising the rainfall intensity variation within a day using a cumulative distribution function (cdf). This cdf is then modified by various linear and nonlinear processes typically represented in hydrological and

  14. GPS Recovery of Daily Hydrologic and Atmospheric Mass Variation: A Methodology and Results From the Australian Continent

    NASA Astrophysics Data System (ADS)

    Han, Shin-Chan; Razeghi, S. Mahdiyeh

    2017-11-01

    We present a methodology to invert a regional set of vertical displacement data from Global Positioning System (GPS) to determine the surface mass redistribution. It is assumed that GPS deformation is a result of the Earth's elastic response to the surface mass load of hydrology, atmosphere, and/or ocean. We develop an algorithm to estimate the spectral information of displacements from "regional" GPS data through regional spherical (Slepian) basis functions and apply the load Love numbers to estimate the mass load. The same approach is applied to determine global mass changes from "global" geopotential change data of Gravity Recovery and Climate Experiment (GRACE). We rigorously examine all systematic errors caused by various truncations (spherical harmonic series and Slepian series) and the smoothing constraint applied to the GPS inversion. We demonstrate the technique by processing 16 years of daily vertical motions determined from 114 GPS stations in Australia. The GPS-inverted surface mass changes are validated against GRACE data, atmosphere and ocean models, and a land surface model. Seasonal and interannual terrestrial mass variations from GPS are in good agreement with GRACE data and the water storage models. The GPS recovery compares better with the water storage model around the smaller coastal basins than two different GRACE solutions. The submonthly mass changes from GPS provide meaningful results agreeing with atmospheric mass changes in central Australia. Finally, it is suggested to integrate GPS and GRACE data to draw a comprehensive picture of daily mass changes on different continents.

  15. Optical imaging of irradiated and non-irradiated hearts (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Bolin, Stephanie; Chen, Guanchu; Medhora, Meetha M.; Camara, Amadou K. S.; Ranji, Mahsa

    2016-03-01

    Objective: In this study, the metabolic state of the heart tissue is studied in a rodent model of ischemia and reperfusion (IR) in rats exposed to irradiation injury using a cryofluorescence imaging technique. Mitochondrial metabolic state is evaluated by autofluorescence of mitochondrial metabolic coenzymes NADH and FAD. The redox ratio (NADH/FAD) is used as a biochemical/metabolic marker of oxidative stress, before, during and after IR. Materials and methods: Hearts were extracted from non-irradiated (control) and irradiated rats (Irr) given 15 Gy whole thorax irradiation rats (WTI). After 35 days, before the onset of radiation pneumonitis, these two groups of hearts were subjected to one of three treatments; Time control (TC; hearts perfused for the duration of the protocol without ischemia or IR), 25 minutes ischemia with no reperfusion and 25 minutes ischemia followed by 60 minutes reperfusion (IR). Hearts were removed from the Langendorff perfusion system and immediately snap frozen in liquid N2 to preserve the metabolic state after injury; 3-dimensional (3D) cryo-fluorescent imager was used to obtain in fixed time NADH and FAD fluorescence images and their distribution across the entire ventricles. In this study, a 30-μm axial resolution was used resulting in 550 cross-section images per heart. The 3D images of the redox ratio and their respective histograms were calculated in the six groups of hearts. Results: We compared the mean values of the redox ratio in each group, which demonstrate a reduced mitochondrial redox state in both irradiated and non-irradiated ischemic hearts and an oxidized mitochondrial redox state for both irradiated and non-irradiated ischemia-reperfusion hearts compared to control hearts. For non-irradiated hearts, ischemia and IR injuries resulted respectively in 61% increase and 54% decrease in redox ratio when compared with TC. For irradiated hearts, ischemia and IR injuries resulted respectively in 90% increase and 50% decrease

  16. Morphological degradation of human hair cuticle due to simulated sunlight irradiation and washing.

    PubMed

    Richena, M; Rezende, C A

    2016-08-01

    Morphological changes in hair surface are undesirable, since they cause shine loss, roughness increase and split ends. These effects occur more frequently in the cuticle, which is the outermost layer of the hair strand, and thus the most exposed to the environmental damages. Sunlight irradiation contributes significantly to these morphological alterations, which motivates the investigation of this effect on hair degradation. In this work, the influence of irradiation and hand-washing steps on the morphology of pigmented and non-pigmented hair cuticle was investigated using field emission scanning electron microscopy (FESEM) and transmission electron microscopy (TEM). To simulate daily conditions, where hair is hand-washed and light exposed, samples of dark brown and gray hair underwent three different conditions: 1) irradiation with a mercury lamp for up to 600h; 2) irradiation with the mercury lamp combined with washes with a sodium lauryl sulphate solution; and 3) only washing. A new preparation procedure was applied for TEM samples to minimize natural variations among different hair strands: a single hair strand was cut into two neighbouring halves and only one of them underwent irradiation and washing. The non-exposed half was used as a control, so that the real effects caused by the controlled irradiation and washing procedures could be highlighted in samples that had very similar morphologies initially. More than 25images/sample were analysed using FESEM (total of 300 images) and ca. 150images/sample were obtained with TEM (total of 900 images). The results presented herein show that the endocuticle and the cell membrane complex (CMC) are the cuticle structures more degraded by irradiation. Photodegradation alone results in fracturing, cavities (Ø≈20-200nm) and cuticle cell lifting, while the washing steps were able to remove cuticle cells (≈1-2 cells removed after 60 washes). Finally, the combined action of irradiation and washing caused the most severe

  17. Irradiation hardening of pure tungsten exposed to neutron irradiation

    DOE PAGES

    Hu, Xunxiang; Koyanagi, Takaaki; Fukuda, Makoto; ...

    2016-08-26

    In this paper, pure tungsten samples have been neutron irradiated in HFIR at 90–850 °C to 0.03–2.2 dpa. A dispersed barrier hardening model informed by the available microstructure data has been used to predict the hardness. Comparison of the model predictions and the measured Vickers hardness reveals the dominant hardening contribution at various irradiation conditions. For tungsten samples irradiated in HFIR, the results indicate that voids and dislocation loops contributed to the hardness increase in the low dose region (<0.3 dpa), while the formation of intermetallic second phase precipitation, resulting from transmutation, dominates the radiation-induced strengthening beginning with a relativelymore » modest dose (>0.6 dpa). Finally, the precipitate contribution is most pronounced for the HFIR irradiations, whereas the radiation-induced defect cluster microstructure can rationalize the entirety of the hardness increase observed in tungsten irradiated in the fast neutron spectrum of Joyo and the mixed neutron spectrum of JMTR.« less

  18. Identification of periods of clear sky irradiance in time series of GHI measurements

    DOE PAGES

    Reno, Matthew J.; Hansen, Clifford W.

    2016-01-18

    In this study, we present a simple algorithm for identifying periods of time with broadband global horizontal irradiance (GHI) similar to that occurring during clear sky conditions from a time series of GHI measurements. Other available methods to identify these periods do so by identifying periods with clear sky conditions using additional measurements, such as direct or diffuse irradiance. Our algorithm compares characteristics of the time series of measured GHI with the output of a clear sky model without requiring additional measurements. We validate our algorithm using data from several locations by comparing our results with those obtained from amore » clear sky detection algorithm, and with satellite and ground-based sky imagery.« less

  19. Identification of periods of clear sky irradiance in time series of GHI measurements

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Reno, Matthew J.; Hansen, Clifford W.

    In this study, we present a simple algorithm for identifying periods of time with broadband global horizontal irradiance (GHI) similar to that occurring during clear sky conditions from a time series of GHI measurements. Other available methods to identify these periods do so by identifying periods with clear sky conditions using additional measurements, such as direct or diffuse irradiance. Our algorithm compares characteristics of the time series of measured GHI with the output of a clear sky model without requiring additional measurements. We validate our algorithm using data from several locations by comparing our results with those obtained from amore » clear sky detection algorithm, and with satellite and ground-based sky imagery.« less

  20. PARAFAC Modeling of Irradiation- and Oxidation-Induced Changes in Fluorescent Dissolved Organic Matter Extracted from Poultry Litter.

    PubMed

    Mangalgiri, Kiranmayi P; Timko, Stephen A; Gonsior, Michael; Blaney, Lee

    2017-07-18

    Parallel factor analysis (PARAFAC) applied to fluorescence excitation emission matrices (EEMs) allows quantitative assessment of the composition of fluorescent dissolved organic matter (DOM). In this study, we fit a four-component EEM-PARAFAC model to characterize DOM extracted from poultry litter. The data set included fluorescence EEMs from 291 untreated, irradiated (253.7 nm, 310-410 nm), and oxidized (UV-H 2 O 2 , ozone) poultry litter extracts. The four components were identified as microbial humic-, terrestrial humic-, tyrosine-, and tryptophan-like fluorescent signatures. The Tucker's congruence coefficients for components from the global (i.e., aggregated sample set) model and local (i.e., single poultry litter source) models were greater than 0.99, suggesting that the global EEM-PARAFAC model may be suitable to study poultry litter DOM from individual sources. In general, the transformation trends of the four fluorescence components were comparable for all poultry litter sources tested. For irradiation at 253.7 nm, ozonation, and UV-H 2 O 2 advanced oxidation, transformation of the humic-like components was slower than that of the tryptophan-like component. The opposite trend was observed for irradiation at 310-410 nm, due to differences in UV absorbance properties of components. Compared to the other EEM-PARAFAC components, the tyrosine-like component was fairly recalcitrant in irradiation and oxidation processes. This novel application of EEM-PARAFAC modeling provides insight into the composition and fate of agricultural DOM in natural and engineered systems.

  1. Intercomparison of spectral irradiance measurements and provision of alternative radiation scheme for CCMs of middle atmosphere

    NASA Astrophysics Data System (ADS)

    Pagaran, Joseph; Weber, Mark; Burrows, John P.

    The Sun's radiative output (total solar irradiance or TSI) determines the thermal structure of the Earth's atmosphere. Its variability is a strong function of wavelength, which drives the photochemistry and general circulation. Contributions to TSI variability from UV wavelengths below 400 nm, i.e. 0.227-day solar rotation or 0.1to be in the 40-60three decades of UV and about a decade of vis-IR observations. Significant progress in UV/vis-IR regions has been achieved with daily monitoring from SCIAMACHY aboard Envisat (ESA) in 2002 and by SIM aboard SORCE (NASA) about a year after. In this contribution, we intercompare SSI measurements from SCIAMACHY and SIM and RGB filters of SPM/VIRGO SoHO: same (a) day and (b) few 27-day time series of spectral measurements in both irradiance and integrated irradiance over selected wavelength intervals. Finally, we show how SSI measurements from GOME, SOLSTICE, in addition to SCIAMACHY and SIM, can be modeled together with solar proxies F10.7 cm, Mg II and sunspot index (PSI) to derive daily SSI variability in the period 1947-2008. The derived variabilities are currently being used as solar input to Bremen's 3D-CTM and are to be recommended as extended alternative to Berlin's FUBRaD radiation scheme. This proxy-based radiation scheme are compared with SATIRE, NRLSSI (or Lean et al.), SUSIM, SSAI (or DeLand et al), and SIP (or Solar2000) models. The use of realistic spectrally resolved solar input to CCMs is to better understand the effects of solar variability on chemistry and temperature in the middle atmosphere over several decades.

  2. UV-B radiation amplification factor determined based on the simultaneous observation of total ozone and global spectral irradiance

    NASA Technical Reports Server (NTRS)

    Ito, T.; Sakoda, Y.; Matsubara, K.; Kajihara, R.; Uekubo, T.; Kobayashi, M.; Shitamichi, M.; Ueno, T.; Ito, M.

    1994-01-01

    The Japan Meteorological Agency started the spectral observation of solar ultraviolet (UV) irradiance on 1 January 1990 at Tateno, Aerological Observatory in Tsukuba (35 deg N, 140 deg E). The observation has been carried out using the Brewer spectrophotometer for the wavelengths from 290 to 325 nm with a 0.5 nm interval every hour from 30 minutes before sunrise to 30 minutes after sunset throughout a year. Because of remarkable similarity within observed spectra, an observed spectrum can be expressed by a simple combination of a reference spectrum and two parameters expressing the deformation of the observed spectrum from the reference. By use of the relation between one of the deformation parameters and the total ozone simultaneously observed with the Dobson spectrophotometer, the possible increase of UV irradiance due to ozone depletion is estimated. For damaging UV, the irradiance possibly increases about 19 percent with the ozone depletion of 10 percent at noon throughout the year in the northern midlatitudes. DUV at noon on the summer solstice possibly increases about 5.6 percent with the ozone depletion of 10 m atm-cm for all latitudes in the Northern Hemisphere.

  3. Dosimetric advantages of a clinical daily adaptive plan selection strategy compared with a non-adaptive strategy in cervical cancer radiation therapy.

    PubMed

    van de Schoot, Agustinus J A J; de Boer, Peter; Visser, Jorrit; Stalpers, Lukas J A; Rasch, Coen R N; Bel, Arjan

    2017-05-01

    Radiation therapy (RT) using a daily plan selection adaptive strategy can be applied to account for interfraction organ motion while limiting organ at risk dose. The aim of this study was to quantify the dosimetric consequences of daily plan selection compared with non-adaptive RT in cervical cancer. Ten consecutive patients who received pelvic irradiation, planning CTs (full and empty bladder), weekly post-fraction CTs and pre-fraction CBCTs were included. Non-adaptive plans were generated based on the PTV defined using the full bladder planning CT. For the adaptive strategy, multiple PTVs were created based on both planning CTs by ITVs of the primary CTVs (i.e., GTV, cervix, corpus-uterus and upper part of the vagina) and corresponding library plans were generated. Daily CBCTs were rigidly aligned to the full bladder planning CT for plan selection. For daily plan recalculation, selected CTs based on initial similarity were deformably registered to CBCTs. Differences in daily target coverage (D 98%  > 95%) and in V 0.5Gy , V 1.5Gy , V 2Gy , D 50% and D 2% for rectum, bladder and bowel were assessed. Non-adaptive RT showed inadequate primary CTV coverage in 17% of the daily fractions. Plan selection compensated for anatomical changes and improved primary CTV coverage significantly (p < 0.01) to 98%. Compared with non-adaptive RT, plan selection decreased the fraction dose to rectum and bowel indicated by significant (p < 0.01) improvements for daily V 0.5Gy , V 1.5Gy , V 2Gy , D 50% and D 2% . However, daily plan selection significantly increased the bladder V 1.5Gy , V 2Gy , D 50% and D 2% . In cervical cancer RT, a non-adaptive strategy led to inadequate target coverage for individual patients. Daily plan selection corrected for day-to-day anatomical variations and resulted in adequate target coverage in all fractions. The dose to bowel and rectum was decreased significantly when applying adaptive RT.

  4. Impact of Abbreviated Filgrastim Schedule on Survival and Hematopoietic Recovery after Irradiation in Four Mouse Strains with Different Radiosensitivity

    PubMed Central

    Satyamitra, Merriline; Kumar, Vidya P.; Biswas, Shukla; Cary, Lynnette; Dickson, Leonora; Venkataraman, Srinivasan; Ghosh, Sanchita P.

    2017-01-01

    Filgrastim (Neupogen®, granulocyte-colony stimulating factor) is among the few countermeasures recommended for management of patients in the event of lethal total-body irradiation. Despite the plethora of studies using filgrastim as a radiation countermeasure, relatively little is known about the optimal dose schedule of filgrastim to mitigate radiation lethality. We evaluated the efficacy of filgrastim in improving 30-day survival of CD2F1 mice irradiated with a lethal dose (LD70/30) in the AFRRI cobalt-60 facility. We tested different schedules of 1, 3, 5,10 or 16 once-daily injections of filgrastim initiated one day after irradiation. Time optimization studies with filgrastim treatment were also performed, beginning 6–48 h postirradiation. Maximum survival was observed with 3 daily doses of 0.17 mg/kg filgrastim. Survival efficacy of the 3-day treatment was compared against the conventional 16-day filgrastim treatment after irradiation in four mouse strains with varying radiation sensitivities: C3H/HeN, C57BL/6, B6C3F1 and CD2F1. Blood indices, bone marrow histopathology and colony forming unit assays were also evaluated. Filgrastim significantly increased 30-day survival (P < 0.001) with a 3-day treatment compared to 16-day treatment. Filgrastim did not prevent cytopenia nadirs, but facilitated faster recovery of white blood cells, neutrophils, red blood cells, platelets, lymphocytes and hematocrits in all four strains. Accelerated hematopoietic recovery was also reflected in faster bone marrow reconstitution and significant increase in hematopoietic progenitors (P < 0.001) in all four mouse strains. These data indicate that prompt and abbreviated filgrastim treatment has potential benefit for triage in the event of a radiological incident for treating acute hematopoietic syndrome. PMID:28362168

  5. Annually and monthly resolved solar irradiance and atmospheric temperature data across the Hawaiian archipelago from 1998 to 2015 with interannual summary statistics.

    PubMed

    Bryce, Richard; Losada Carreño, Ignacio; Kumler, Andrew; Hodge, Bri-Mathias; Roberts, Billy; Brancucci Martinez-Anido, Carlo

    2018-08-01

    This article contains data and summary statistics of solar irradiance and dry bulb temperature across the Hawaiian archipelago resolved on a monthly basis and spanning years 1998-2015. This data was derived in association with an article titled "Consequences of Neglecting the Interannual Variability of the Solar Resource: A Case Study of Photovoltaic Power Among the Hawaiian Islands" (Bryce et al., 2018 [7]). The solar irradiance data is presented in terms of Direct Normal Irradiance (DNI), Diffuse Horizontal Irradiance (DHI), and Global Horizontal Irradiance (GHI) and was obtained from the satellite-derived data contained in the National Solar Radiation Database (NSRDB). The temperature data is also obtained from this source. We have processed the NSRDB data and compiled these monthly resolved data sets, along with interannual summary statistics including the interannual coefficient of variability.

  6. The influence of late-stage pupal irradiation and increased irradiated: un-irradiated male ratio on mating competitiveness of the malaria mosquito Anopheles arabiensis Patton.

    PubMed

    Helinski, M E H; Knols, B G J

    2009-06-01

    Competitiveness of released males in genetic control programmes is of critical importance. In this paper, we explored two scenarios to compensate for the loss of mating competitiveness after pupal stage irradiation in males of the malaria mosquito Anopheles arabiensis. First, competition experiments with a higher ratio of irradiated versus un-irradiated males were performed. Second, pupae were irradiated just prior to emergence and male mating competitiveness was determined. Males were irradiated in the pupal stage with a partially or fully-sterilizing dose of 70 or 120 Gy, respectively. Pupae were irradiated aged 20-26 h (young) as routinely performed, or the pupal stage was artificially prolonged by cooling and pupae were irradiated aged 42-48 h (old). Irradiated males competed at a ratio of 3:1:1 to un-irradiated males for mates in a large cage design. At the 3:1 ratio, the number of females inseminated by males irradiated with 70 Gy as young pupae was similar to the number inseminated by un-irradiated males for the majority of the replicates. At 120 Gy, significantly fewer females were inseminated by irradiated than by un-irradiated males. The irradiation of older pupae did not result in a significantly improved male mating competitiveness compared to the irradiation of young pupae. Our findings indicate that the loss of competitiveness after pupal stage irradiation can be compensated for by a threefold increase of irradiated males, but only for the partially-sterilizing dose. In addition, cooling might be a useful tool to facilitate handling processes of large numbers of mosquitoes in genetic control programmes.

  7. Development of Sub-Daily Intensity Duration Frequency (IDF) Curves for Major Urban Areas in India

    NASA Astrophysics Data System (ADS)

    Ali, H.; Mishra, V.

    2014-12-01

    Extreme precipitation events disrupt urban transportation and cause enormous damage to infrastructure. Urban areas are fast responding catchments due to significant impervious surface. Stormwater designs based on daily rainfall data provide inadequate information. We, therefore, develop intensity-duration-frequency curves using sub-daily (1 hour to 12 hour) rainfall data for 57 major urban areas in India. While rain gage stations data from urban areas are most suitable, but stations are unevenly distributed and their data have gaps and inconsistencies. Therefore, we used hourly rainfall data from the Modern Era Retrospective-analysis for Research and Applications (MERRA), which provides a long term data (1979 onwards). Since reanalysis products have uncertainty associated with them we need to enhance their accuracy before their application. We compared daily rain gage station data obtained from Global Surface Summary of Day Data (GSOD) available for 65 stations for the period of 2000-2010 with gridded daily rainfall data provided by Indian Meteorological Department (IMD). 3-hourly data from NOAA/Climate Prediction Center morphing technique (CMORPH), Precipitation Estimation from Remotely Sensed Information using Artificial Neural Networks (PERSIANN), and the Tropical Rainfall Measuring Mission (TRMM) Multisatellite Precipitation Analysis (TMPA) were aggregated to daily for comparison with GSOD station data . TMPA is found to be best correlated with GSOD data. We used TMPA data to correct MERRA's hourly precipitation, which were applied to develop IDF curves. We compared results with IDF curves from empirical methods and found substantial disparities in the existing stormwater designs in India.

  8. [Stochastic characteristics of daily precipitation and its spatiotemporal difference over China based on information entropy].

    PubMed

    Li, Xin Xin; Sang, Yan Fang; Xie, Ping; Liu, Chang Ming

    2018-04-01

    Daily precipitation process in China showed obvious randomness and spatiotemporal variation. It is important to accurately understand the influence of precipitation changes on control of flood and waterlogging disaster. Using the daily precipitation data measured at 520 stations in China during 1961-2013, we quantified the stochastic characteristics of daily precipitation over China based on the index of information entropy. Results showed that the randomness of daily precipitation in the southeast region were larger than that in the northwest region. Moreover, the spatial distribution of stochastic characteristics of precipitation was different at various grades. Stochastic characteri-stics of P 0 (precipitation at 0.1-10 mm) was large, but the spatial variation was not obvious. The stochastic characteristics of P 10 (precipitation at 10-25 mm) and P 25 (precipitation at 25-50 mm) were the largest and their spatial difference was obvious. P 50 (precipitation ≥50 mm) had the smallest stochastic characteristics and the most obviously spatial difference. Generally, the entropy values of precipitation obviously increased over the last five decades, indicating more significantly stochastic characteristics of precipitation (especially the obvious increase of heavy precipitation events) in most region over China under the scenarios of global climate change. Given that the spatial distribution and long-term trend of entropy values of daily precipitation could reflect thespatial distribution of stochastic characteristics of precipitation, our results could provide scientific basis for the control of flood and waterlogging disaster, the layout of agricultural planning, and the planning of ecological environment.

  9. Memantine extended release (28 mg once daily): a review of its use in Alzheimer's disease.

    PubMed

    Plosker, Greg L

    2015-05-01

    Memantine is an uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist that is a well-established treatment option for moderate to severe dementia of the Alzheimer's type, either alone or in combination with cholinesterase inhibitors. The immediate-release (IR) formulations of memantine (tablets and oral solution) have been available in numerous countries, including the USA, for more than a decade and are administered orally twice daily at a maximum recommended total daily dosage of 20 mg/day. The memantine extended-release (ER) (Namenda XR(®)) 28 mg once-daily capsule formulation was approved in the USA in 2010 and became available more recently. The potential advantages of memantine ER over the IR formulation include a more convenient dosage regimen and lower pill burden that may improve adherence to therapy; also, memantine ER capsules may be opened and the contents sprinkled on applesauce for patients who have difficulty swallowing. Memantine ER provides a higher total daily dosage than the recommended memantine IR regimen and pharmacokinetic data indicate greater exposure with the ER formulation, but the clinical implications of this are unclear, as the two formulations have not been assessed in a comparative clinical trial. The efficacy of memantine ER 28 mg once daily was demonstrated in a large, multinational, phase III trial, which showed that the addition of memantine ER to ongoing oral cholinesterase inhibitors improved key outcomes compared with cholinesterase inhibitor monotherapy, including measures of cognition and global status, which were the co-primary endpoints of the study. The most common adverse events were headache, diarrhoea and dizziness.

  10. Effects of laser acupoint irradiation on blood glucose and glycosylated hemoglobin in type 2 diabetes mellitus

    NASA Astrophysics Data System (ADS)

    Hui-Hui, Liu; Guo-Xin, Xiong; Li-Ping, Zhang

    2016-06-01

    To investigate the effects of semiconductor laser acupoint irradiation on blood glucose, glycosylated hemoglobin and physical fitness in type 2 diabetes mellitus, 44 cases of type 2 diabetic patients were randomly divided into a control group and a treatment group. All patients in both groups were given a drug treatment. The Hegu, Quchi and Zusanli acupoints of patients in the treatment group were then irradiated daily for 15 d with a 10 MW semiconductor laser. Before and after treatment, patients in both groups underwent a variety of tests and measurements: a two-hour postprandial blood glucose test; a glycosylated hemoglobin test and body mass index (BMI), waist-to-hip ratio (WHR) and body fat percentage (BFP) measurements. The data detected after treatment greatly decreased in the treatment group and was significantly different from that in the control group. It is shown that the acupoint irradiation with a semiconductor laser can improve two-hour postprandial blood glucose, glycosylated hemoglobin and some physical fitness measurements in type 2 diabetes mellitus patients.

  11. Low-energy helium-neon laser irradiation and the tensile strength of incisional wounds in the rat.

    PubMed

    Broadley, C; Broadley, K N; Disimone, G; Riensch, L; Davidson, J M

    1995-01-01

    Low-level laser energy has been reported to modulate the wound healing process in some but not all studies. To examine this hypothesis, we investigated incisional wounds made on the dorsal pelt of rats for changes in the healing produced by low-level irradiation with a helium-neon laser. The incisions were made with a scalpel and closed with sutures. The rats were irradiated daily for 12 days with four levels of laser light (0.0, 0.47, 0.93, and 1.73 J/cm(2)). Analysis of wound tensile strength indicated a possible strengthening of fresh wounds at the highest levels of irradiation (1.73 J/cm(2)). No change was observed in the tensile strength of formalin-fixed wounds. The distribution of measured tensile strengths did not follow normal statistics; instead they showed a platykurtic distribution. Using resampling statistics, where no assumption is made as to the nature of the distribution, we found that the results were contrary to other studies: no biostimulatory effect was seen.

  12. Unravelling daily human mobility motifs

    PubMed Central

    Schneider, Christian M.; Belik, Vitaly; Couronné, Thomas; Smoreda, Zbigniew; González, Marta C.

    2013-01-01

    Human mobility is differentiated by time scales. While the mechanism for long time scales has been studied, the underlying mechanism on the daily scale is still unrevealed. Here, we uncover the mechanism responsible for the daily mobility patterns by analysing the temporal and spatial trajectories of thousands of persons as individual networks. Using the concept of motifs from network theory, we find only 17 unique networks are present in daily mobility and they follow simple rules. These networks, called here motifs, are sufficient to capture up to 90 per cent of the population in surveys and mobile phone datasets for different countries. Each individual exhibits a characteristic motif, which seems to be stable over several months. Consequently, daily human mobility can be reproduced by an analytically tractable framework for Markov chains by modelling periods of high-frequency trips followed by periods of lower activity as the key ingredient. PMID:23658117

  13. CD47 Receptor Globally Regulates Metabolic Pathways That Control Resistance to Ionizing Radiation*

    PubMed Central

    Miller, Thomas W.; Soto-Pantoja, David R.; Schwartz, Anthony L.; Sipes, John M.; DeGraff, William G.; Ridnour, Lisa A.; Wink, David A.; Roberts, David D.

    2015-01-01

    Modulating tissue responses to stress is an important therapeutic objective. Oxidative and genotoxic stresses caused by ionizing radiation are detrimental to healthy tissues but beneficial for treatment of cancer. CD47 is a signaling receptor for thrombospondin-1 and an attractive therapeutic target because blocking CD47 signaling protects normal tissues while sensitizing tumors to ionizing radiation. Here we utilized a metabolomic approach to define molecular mechanisms underlying this radioprotective activity. CD47-deficient cells and cd47-null mice exhibited global advantages in preserving metabolite levels after irradiation. Metabolic pathways required for controlling oxidative stress and mediating DNA repair were enhanced. Some cellular energetics pathways differed basally in CD47-deficient cells, and the global declines in the glycolytic and tricarboxylic acid cycle metabolites characteristic of normal cell and tissue responses to irradiation were prevented in the absence of CD47. Thus, CD47 mediates signaling from the extracellular matrix that coordinately regulates basal metabolism and cytoprotective responses to radiation injury. PMID:26311851

  14. Wavelength Dependence of Solar Flare Irradiation and its Influence on the Thermosphere

    NASA Technical Reports Server (NTRS)

    Huang, Yanshi; Richmond, Arthur D.; Deng, Yue; Qian, L.; Solomon, S.; Chamberlin, P.

    2012-01-01

    The wavelength dependence of solar flare enhancement is one of the important factors determining how the Thermosphere-Ionosphere (T-I) system response to flares. To investigate the wavelength dependence of solar flare, the Flare Irradiance Spectral Model (FISM) has been run for 34 X-class flares. The results show that the percentage increases of solar irradiance at flare peak comparing to pre-flare condition have a clear wavelength dependence. In the wavelength range between 0 - 195 nm, it can vary from 1% to 10000%. The solar irradiance enhancement is largest ( 1000%) in the XUV range (0 - 25 nm), and is about 100% in EUV range (25 - 120 nm). The influence of different wavebands on the T-I system during the October 28th, 2003 flare (X17.2-class) has also been examined using the latest version of National Center for Atmospheric Research (NCAR) Thermosphere- Ionosphere-Electrodynamics General Circulation Model (TIE-GCM). While the globally integrated solar energy deposition is largest in the 0 - 14 nm waveband, the impact of solar irradiance enhancement on the thermosphere at 400 km is largest for 25 - 105 nm waveband. The effect of 122 - 195 nm is small in magnitude, but it decays slowly.

  15. Mass spectrometric evidence for the modification of small molecules in a cobalt-60-irradiated rodent diet.

    PubMed

    Prasain, J K; Wilson, L S; Arabshahi, A; Grubbs, C; Barnes, S

    2017-08-01

    The purpose of this study was to investigate the effect of radiation on the content of animal diet constituents using global metabolomics. Aqueous methanolic extracts of control and cobalt-60-irradiated Teklad 7001 diets were comprehensively analyzed using nano-liquid chromatography-MS/MS. Among the over 2000 ions revealed by XCMS followed by data preprocessing, 94 positive and 143 negative metabolite ions had greater than 1.5-fold changes and p-values <0.01. Use of MetaboAnalyst statistical software demonstrated complete separation of the irradiated and non-radiated diets in unsupervised principal components analysis and supervised partial least squares discriminant analysis. Irradiation led to an increase in the content of phytochemicals such as glucosinolates and oxidized lipids in the diet. Twenty-eight metabolites that were significantly changed in the irradiated samples were putatively identified at the level of molecular formulae by MS/MS. MS/MS ALL analysis of chloroform-methanol extracts of the irradiated diet showed increased levels of a number of unique linoleic acid-derived branched fatty acid esters of hydroxy fatty acids. These data imply that gamma irradiation of animal diets causes chemical changes to dietary components, which in turn may influence the risk of mammary cancer. Copyright © 2017 John Wiley & Sons, Ltd. Copyright © 2017 John Wiley & Sons, Ltd.

  16. Dosimetry Formalism and Implementation of a Homogenous Irradiation Protocol to Improve the Accuracy of Small Animal Whole-Body Irradiation Using a Cesium-137 Irradiator

    PubMed Central

    Brodin, N. Patrik; Chen, Yong; Yaparpalvi, Ravindra; Guha, Chandan; Tomé, Wolfgang A.

    2015-01-01

    Shielded 137Cs irradiators are routinely used in pre-clinical radiation research to perform in vitro or in vivo investigations. Without appropriate dosimetry and irradiation protocols in place, there can be large uncertainty in the delivered dose of radiation between irradiated subjects that could lead to inaccurate and possibly misleading results. Here, a dosimetric evaluation of the JL Shepard Mark I-68A 137Cs irradiator and an irradiation technique for whole-body irradiation of small animals that allows one to limit the between subject variation in delivered dose to ±3% are provided. Mathematical simulation techniques and Gafchromic EBT film were used to describe the region within the irradiation cavity with homogeneous dose distribution (100% ±5%), the dosimetric impact of varying source-to-subject distance, and the variation in attenuation thickness due to turntable rotation. Furthermore, an irradiation protocol and dosimetry formalism that allows calculation of irradiation time for whole-body irradiation of small animals is proposed, that is designed to ensure a more consistent dose delivery between irradiated subjects. To compare this protocol with the conventional irradiation protocol suggested by the vendor, high-resolution film dosimetry measurements evaluating the dose difference between irradiation subjects and the dose distribution throughout subjects was performed, using phantoms resembling small animals. Based on these results, there can be considerable variation in the delivered dose of > ±5% using the conventional irradiation protocol for whole-body irradiation doses below 5 Gy. Using the proposed irradiation protocol this variability can be reduced to within ±3% and the dosimetry formalism allows for more accurate calculation of the irradiation time in relation to the intended prescription dose. PMID:26710162

  17. A Phase 1/2 Trial of a Combination of Paclitaxel and Trastuzumab With Daily Irradiation or Paclitaxel Alone With Daily Irradiation After Transurethral Surgery for Noncystectomy Candidates With Muscle-Invasive Bladder Cancer (Trial NRG Oncology RTOG 0524)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Michaelson, M. Dror, E-mail: dmichaelson1@partners.org; Hu, Chen; Sydney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland

    Purpose: Bladder preservation therapy is an effective treatment for muscle-invasive urothelial carcinoma (UC). In this study we treated noncystectomy candidates with daily radiation and weekly paclitaxel for 7 weeks. Patients whose tumors showed her2/neu overexpression were additionally treated with weekly trastuzumab. Methods and Materials: Sixty-eight evaluable patients were treated with radiation therapy and either paclitaxel + trastuzumab (group 1) or paclitaxel alone (group 2). Groups were assigned on the basis of her2/neu immunohistochemistry results. Patients received 1.8-Gy fractions to a total dose of 64.8 Gy. The primary endpoint of the study was treatment-related toxicity, and secondary endpoints included complete response (CR) rate, protocol completionmore » rate, and survival. Results: A total of 20 evaluable patients were treated in group 1 and 46 patients in group 2. Acute treatment-related adverse events (AEs) were observed in 7 of 20 patients in group 1 (35%) and 14 of 46 patients in group 2 (30.4%). Protocol therapy was completed by 60% (group 1) and 74% (group 2) of patients. Most incompletions were due to toxicity, and the majority of AEs were gastrointestinal, including 1 grade 5 AE (group 1). Two other deaths (both in group 2) were unrelated to protocol therapy. No unexpected cardiac, hematologic, or other toxicities were observed. The CR rate at 1 year was 72% for group 1 and 68% for group 2. Conclusions: In patients with muscle-invasive UC who are not candidates for cystectomy, daily radiation combined with paclitaxel is an effective treatment strategy with a high completion rate and moderate toxicity. In patients with her2/neu-positive tumors, a group generally considered to have worse outcomes, the addition of trastuzumab appears to result in comparable efficacy and toxicity. Further biomarker-driven trials should be undertaken in advancing treatment of this challenging disease.« less

  18. New and Updated Gridded Analysis Products provided by the Global Precipitation Climatology Centre (GPCC)

    NASA Astrophysics Data System (ADS)

    Ziese, Markus; Schneider, Udo; Meyer-Christoffer, Anja; Finger, Peter; Schamm, Kirstin; Rustemeier, Elke; Becker, Andreas

    2016-04-01

    Since its start in 1989 the Global Precipitation Climatology Centre (GPCC) performs global analyses of monthly precipitation for the earth's land-surface on the basis of in-situ measurements. Meanwhile, the data set has continuously grown both in temporal coverage (original start of the evaluation period was 1986), as well as extent and quality of the underlying data base. The high spatio-temporal variability of precipitation requires an accordingly high density of measurement data. Data collected from national meteorological and hydrological services are the core of the GPCC data base, supported by global and regional data collections. Also the GPCC receives SYNOP and CLIMAT reports via WMO-GTS, which are mainly applied for near-real-time products. A high quality control effort is undertaken to remove miscoded and temporal or spatial dislocated data before entry into the GPCC archive, serving the basis for further interpolation and product generation. The GPCC archive holds records from almost 100 000 stations, among those three quarters with records long enough to serve the data basis of the GPCC suite of global precipitation products, comprising near-real-time as well as non-real-time products. Near-real-time products are the 'First Guess Monthly', 'First Guess Daily', 'Monitoring Product' and 'GPCC Drought Index'. These products are based on WMO-GTS data, e.g., SYNOP and CLIMAT reports and monthly totals calculated at CPC. Non-real-time products are the 'Full Data Monthly', 'Full Data Daily', 'Climatology', and 'HOMPRA-Europe'. Data from national meteorological and hydrological services and regional and global data collections are mainly used to calculate these products. Also WMO-GTS data are used if no other data are available. The majority of the products were released in an updated version, but 'Full Data Daily' and HOMPRA-Europe' are new products provided the first time. 'Full Data Daily' is a global analysis of daily precipitation totals from 1988 to 2013

  19. Irradiated foods

    MedlinePlus

    ... materials that kill bacteria. The process is called irradiation. It is used to remove germs from food. ... it reduces the risk for food poisoning . Food irradiation is used in many countries. It was first ...

  20. The ability of filgrastim to mitigate mortality following LD50/60 total-body irradiation is administration time-dependent.

    PubMed

    Farese, Ann M; Brown, Cassandra R; Smith, Cassandra P; Gibbs, Allison M; Katz, Barry P; Johnson, Cynthia S; Prado, Karl L; MacVittie, Thomas J

    2014-01-01

    The identification of the optimal administration schedule for an effective medical countermeasure is critical for the effective treatment of individuals exposed to potentially lethal doses of radiation. The efficacy of filgrastim (Neupogen®), a potential medical countermeasure, to improve survival when initiated at 48 h following total body irradiation in a non-human primate model of the hematopoietic syndrome of the acute radiation syndrome was investigated. Animals were exposed to total body irradiation, antero-posterior exposure, total midline tissue dose of 7.5 Gy, (target lethal dose 50/60) delivered at 0.80 Gy min, using linear accelerator-derived 6 MV photons. All animals were administered medical management. Following irradiation on day 0, filgrastim (10 μg kg d) or the control (5% dextrose in water) was administered subcutaneously daily through effect (absolute neutrophil count ≥ 1,000 cells μL for three consecutive days). The study (n = 80) was powered to demonstrate a 25% improvement in survival following the administration of filgrastim or control beginning at 48 ± 4 h post-irradiation. Survival analysis was conducted on the intention-to-treat population using a two-tailed null hypothesis at a 5% significance level. Filgrastim, initiated 48 h after irradiation, did not improve survival (2.5% increase, p = 0.8230). These data demonstrate that efficacy of a countermeasure to mitigate lethality in the hematopoietic syndrome of the acute radiation syndrome can be dependent on the interval between irradiation and administration of the medical countermeasure.

  1. Random matrix theory and cross-correlations in global financial indices and local stock market indices

    NASA Astrophysics Data System (ADS)

    Nobi, Ashadun; Maeng, Seong Eun; Ha, Gyeong Gyun; Lee, Jae Woo

    2013-02-01

    We analyzed cross-correlations between price fluctuations of global financial indices (20 daily stock indices over the world) and local indices (daily indices of 200 companies in the Korean stock market) by using random matrix theory (RMT). We compared eigenvalues and components of the largest and the second largest eigenvectors of the cross-correlation matrix before, during, and after the global financial the crisis in the year 2008. We find that the majority of its eigenvalues fall within the RMT bounds [ λ -, λ +], where λ - and λ + are the lower and the upper bounds of the eigenvalues of random correlation matrices. The components of the eigenvectors for the largest positive eigenvalues indicate the identical financial market mode dominating the global and local indices. On the other hand, the components of the eigenvector corresponding to the second largest eigenvalue are positive and negative values alternatively. The components before the crisis change sign during the crisis, and those during the crisis change sign after the crisis. The largest inverse participation ratio (IPR) corresponding to the smallest eigenvector is higher after the crisis than during any other periods in the global and local indices. During the global financial the crisis, the correlations among the global indices and among the local stock indices are perturbed significantly. However, the correlations between indices quickly recover the trends before the crisis.

  2. Choline magnesium trisalicylate: comparative pharmacokinetic study of once-daily and twice-daily dosages.

    PubMed

    Levitt, M J; Kann, J

    1984-07-01

    This randomized crossover study compared the pharmacokinetics of choline magnesium trisalicylate tablets administered once daily (3000 mg of salicylate) or twice daily (1500 mg of salicylate) for six d. Serum salicylate levels were measured by HPLC. Mean "trough" concentrations fell within the therapeutic range (5-30 mg/dL) with either regimen and were relatively constant, indicating that the steady state had been reached. The 24-h area under the salicylate curve (AUC0-24 h) after the final 3000-mg salicylate dose averaged about twice the mean 12-h AUC after the last 1500-mg dose, indicating that the two dosing regimens were equally bioavailable. Clinical observations and results of laboratory safety studies indicate that both dosage schedules of the drug are well tolerated. The present findings support the once-daily therapeutic use of choline magnesium trisalicylate.

  3. Climate-induced variations in global wildfire danger from 1979 to 2013

    PubMed Central

    Jolly, W. Matt; Cochrane, Mark A.; Freeborn, Patrick H.; Holden, Zachary A.; Brown, Timothy J.; Williamson, Grant J.; Bowman, David M. J. S.

    2015-01-01

    Climate strongly influences global wildfire activity, and recent wildfire surges may signal fire weather-induced pyrogeographic shifts. Here we use three daily global climate data sets and three fire danger indices to develop a simple annual metric of fire weather season length, and map spatio-temporal trends from 1979 to 2013. We show that fire weather seasons have lengthened across 29.6 million km2 (25.3%) of the Earth's vegetated surface, resulting in an 18.7% increase in global mean fire weather season length. We also show a doubling (108.1% increase) of global burnable area affected by long fire weather seasons (>1.0 σ above the historical mean) and an increased global frequency of long fire weather seasons across 62.4 million km2 (53.4%) during the second half of the study period. If these fire weather changes are coupled with ignition sources and available fuel, they could markedly impact global ecosystems, societies, economies and climate. PMID:26172867

  4. Thermal performance curves under daily thermal fluctuation: A study in helmeted water toad tadpoles.

    PubMed

    Bartheld, José L; Artacho, Paulina; Bacigalupe, Leonardo

    2017-12-01

    Most research in physiological ecology has focused on the effects of mean changes in temperature under the classic "hot vs cold" acclimation treatment; however, current evidence suggests that an increment in both the mean and variance of temperature could act synergistically to amplify the negative effects of global temperature increase and how it would affect fitness and performance-related traits in ectothermic organisms. We assessed the effects of acclimation to daily variance of temperature on thermal performance curves of swimming speed in helmeted water toad tadpoles (Calyptocephalella gayi). Acclimation treatments were 20°C ± 0.1 SD (constant) and 20°C ± 1.5 SD (fluctuating). We draw two key findings: first, tadpoles exposed to daily temperature fluctuation had reduced maximal performance (Z max ), and flattened thermal performance curves, thus supporting the "vertical shift or faster-slower" hypothesis, and suggesting that overall swimming performance would be lower through an examination of temperatures under more realistic and ecologically-relevant fluctuating regimens; second, there was significant interindividual variation in performance traits by means of significant repeatability estimates. Our present results suggest that the widespread use of constant acclimation temperatures in laboratory experiments to estimate thermal performance curves (TPCs) may lead to an overestimation of actual organismal performance. We encourage the use of temperature fluctuation acclimation treatments to better understand the variability of physiological traits, which predict ecological and evolutionary responses to global change. Copyright © 2017 Elsevier Ltd. All rights reserved.

  5. Sequential estimation of surface water mass changes from daily satellite gravimetry data

    NASA Astrophysics Data System (ADS)

    Ramillien, G. L.; Frappart, F.; Gratton, S.; Vasseur, X.

    2015-03-01

    We propose a recursive Kalman filtering approach to map regional spatio-temporal variations of terrestrial water mass over large continental areas, such as South America. Instead of correcting hydrology model outputs by the GRACE observations using a Kalman filter estimation strategy, regional 2-by-2 degree water mass solutions are constructed by integration of daily potential differences deduced from GRACE K-band range rate (KBRR) measurements. Recovery of regional water mass anomaly averages obtained by accumulation of information of daily noise-free simulated GRACE data shows that convergence is relatively fast and yields accurate solutions. In the case of cumulating real GRACE KBRR data contaminated by observational noise, the sequential method of step-by-step integration provides estimates of water mass variation for the period 2004-2011 by considering a set of suitable a priori error uncertainty parameters to stabilize the inversion. Spatial and temporal averages of the Kalman filter solutions over river basin surfaces are consistent with the ones computed using global monthly/10-day GRACE solutions from official providers CSR, GFZ and JPL. They are also highly correlated to in situ records of river discharges (70-95 %), especially for the Obidos station where the total outflow of the Amazon River is measured. The sparse daily coverage of the GRACE satellite tracks limits the time resolution of the regional Kalman filter solutions, and thus the detection of short-term hydrological events.

  6. Combined treatment of UVA irradiation and antibiotics induces greater bactericidal effects on Vibrio parahaemolyticus.

    PubMed

    Hou, Yanfei; Nakahashi, Mutsumi; Mawatari, Kazuaki; Shimohata, Takaaki; Uebanso, Takashi; Harada, Yumi; Tsunedomi, Akari; Emoto, Takahiro; Akutagawa, Masatake; Kinouchi, Yohsuke; Takahashi, Akira

    2016-01-01

    The presence of antibiotics in the environment and their subsequent impact on the development of multi-antibiotic resistant bacteria has raised concerns globally. Consequently, much research is focused on a method to produce a better disinfectant. We have established a disinfectant system using UVA-LED that inactivates pathogenic bacteria. We assessed the bactericidal efficiency of a combination of UVA-LED and antibiotics against Vibrio parahaemolyticus. Combined use of antibiotic drugs and UVA irradiation was more bactericidal than UVA irradiation or antibacterial drugs alone. The bactericidal synergy was observed at low concentrations of each drug that are normally unable to kill the bacteria. This combination has the potential to become a sterilization technology.

  7. [Chronic daily headache: clinical presentation].

    PubMed

    Krymchantowski, A V; Moreira Filho, P F

    2000-06-01

    Chronic daily headache (CDH) represents a group of any headache disorder that occurs on a daily or near daily basis, for longer than 6 months. Even though it is a common problem, it is not a well defined disorder, resulting in controversies regarding its identification, description and approach. Three hundred patients, 232 women and 68 men, ages 16 to 86 (mean 38 years old for the women and 42 for the men), attending a headache center and fulfilling the proposed criteria for CDH (Silberstein et al.) and presenting headache 28 days per month were retrospectively studied. The clinical features allowed the primary headache diagnosis, before the transformation into daily presentation as: transformed migraine (TM ) in 271 patients (90,3%), chronic tension-type headache (CTTH) in 26 patients (8,7%) and new daily persistent headache (NDPH) in 3 patients (1%). Among the TM patients, the most observed presentation was pressure or tightening, bilateral fronto-temporal, moderate non-continuous headache, with a progressive onset. The association with nausea and phonophobia was demonstrated in 60% and 32% of the patients respectively. The association with photophobia and sleep disturbances, as well as the occurrence of intermittent headache attacks, was different among male and female patients. With regard to the CTTH patients, pressure or tightening, bilateral fronto-temporal, moderate non-continuous headache, with sleep disturbances and no associated symptoms, was the predominant presentation.

  8. The effects of employment status and daily stressors on time spent on daily household chores in middle-aged and older adults.

    PubMed

    Wong, Jen D; Almeida, David M

    2013-02-01

    This study examines how employment status (worker vs. retiree) and life course influences (age, gender, and marital status) are associated with time spent on daily household chores. Second, this study assesses whether the associations between daily stressors and time spent on daily household chores differ as a function of employment status and life course influences. Men and women aged 55-74 from the National Study of Daily Experiences (N = 268; 133 workers and 135 retirees), a part of the National Survey of Midlife in the United States (MIDUS), completed telephone interviews regarding their daily experiences across 8 consecutive evenings. Working women spent more than double the amount of time on daily household chores than working men. Unmarried retirees spent the most time on daily household chores in comparison to their counterparts. There was a trend toward significance for the association between home stressors from the previous day and time spent on daily household chores as a function of employment and marital status. These findings highlight the importance of gender and marital status in the associations between employment status and time spent on daily household chores and the role that daily stressors, in particular home stressful events, have on daily household chore participation.

  9. Randomized controlled trial comparing impact on platelet reactivity of twice-daily with once-daily aspirin in people with Type 2 diabetes.

    PubMed

    Bethel, M A; Harrison, P; Sourij, H; Sun, Y; Tucker, L; Kennedy, I; White, S; Hill, L; Oulhaj, A; Coleman, R L; Holman, R R

    2016-02-01

    Reduced aspirin efficacy has been demonstrated in people with Type 2 diabetes. Because increased platelet reactivity and/or turnover are postulated mechanisms, we examined whether higher and/or more frequent aspirin dosing might reduce platelet reactivity more effectively. Participants with Type 2 diabetes (n = 24) but without known cardiovascular disease were randomized in a three-way crossover design to 2-week treatment periods with aspirin 100 mg once daily, 200 mg once daily or 100 mg twice daily. The primary outcome was platelet reactivity, assessed using the VerifyNow(™) ASA method. Relationships between platelet reactivity and aspirin dosing were examined using generalized linear mixed models with random subject effects. Platelet reactivity decreased from baseline with all doses of aspirin. Modelled platelet reactivity was more effectively reduced with aspirin 100 mg twice daily vs. 100 mg once daily, but not vs. 200 mg once daily. Aspirin 200 mg once daily did not differ from 100 mg once daily. Aspirin 100 mg twice daily was also more effective than once daily as measured by collagen/epinephrine-stimulated platelet aggregation and urinary thromboxane levels, with a similar trend measured by serum thromboxane levels. No episodes of bleeding occurred. In Type 2 diabetes, aspirin 100 mg twice daily reduced platelet reactivity more effectively than 100 mg once daily, and numerically more than 200 mg once daily. Clinical outcome trials evaluating primary cardiovascular disease prevention with aspirin in Type 2 diabetes may need to consider using a more frequent dosing schedule. © 2015 The Authors. Diabetic Medicine © 2015 Diabetes UK.

  10. Use of Irradiated Foods

    NASA Technical Reports Server (NTRS)

    Brynjolfsson, A.

    1985-01-01

    The safety of irradiated foods is reviewed. Guidelines and regulations for processing irradiated foods are considered. The radiolytic products formed in food when it is irradiated and its wholesomeness is discussed. It is concluded that food irradiation processing is not a panacea for all problems in food processing but when properly used will serve the space station well.

  11. A 7.5-Year Dataset of SSM/I-Derived Surface Turbulent Fluxes Over Global Oceans

    NASA Technical Reports Server (NTRS)

    Chou, Shu-Hsien; Shie, Chung-Lin; Atlas, Robert M.; Adizzone, Joe; Nelkin, Eric; Starr, David OC. (Technical Monitor)

    2001-01-01

    The global air-sea turbulent fluxes are needed for driving ocean models and validating coupled ocean-atmosphere global models. A method was developed to retrieve surface air humidity from the radiances measured by the Special Sensor Microwave/Imager (SSM/I) Using both SSM/I-retrieved surface wind and air humidity, they computed daily turbulent fluxes over global oceans with a stability-dependent bulk scheme. Based on this method, we have produced Version 1 of Goddard Satellite-Based Surface Turbulent Fluxes (GSSTF) dataset from the SSM/I data and other data. It provides daily- and monthly-mean surface turbulent fluxes and some relevant parameters over global oceans for individual F8, F10, and F11 satellites covering the period July 1987-December 1994. It also provides 1988-94 annual- and monthly-mean climatologies of the same variables, using only F8 and F1 1 satellite data. It has a spatial resolution of 2.0 degrees x 2.5 degrees lat-long and is archived at the NASA/GSFC DAAC. The purpose of this paper is to present an updated assessment of the GSSTF 1.0 dataset.

  12. Daily job demands and employee work engagement: The role of daily transformational leadership behavior.

    PubMed

    Breevaart, Kimberley; Bakker, Arnold B

    2018-07-01

    Using job demands-resources (JD-R) theory, the present study integrates the challenge stressor-hindrance stressor framework and leadership theory to investigate the relationship between daily transformational leadership behavior and employee work engagement. We hypothesized that daily transformational leadership behavior (a) sustains employee work engagement on days characterized by high challenge job demands, and (b) protects work engagement on days characterized by high hindrance job demands. Teachers filled out a short online questionnaire at the end of each workday during a 2-week period (N = 271 × 5.68 days = 1539). Results of latent moderated structural equation modeling showed that teachers' daily challenge demands (workload and cognitive demands) had a positive relationship with work engagement on the days transformational leadership was high (vs. low). In addition, teachers' daily hindrance demands (role-conflict, but not family to work conflict) had a negative relationship with work engagement on the days transformational leadership was low (vs. high). These findings show that the function of transformational leadership behavior changes from day to day, and depends on the type of job demand. We discuss the practical and theoretical implications of these findings. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

  13. Productive and counterproductive job crafting: A daily diary study.

    PubMed

    Demerouti, Evangelia; Bakker, Arnold B; Halbesleben, Jonathon R B

    2015-10-01

    The present study aims to uncover the way daily job crafting influences daily job performance (i.e., task performance, altruism, and counterproductive work behavior). Job crafting was conceptualized as "seeking resources," "seeking challenges," and "reducing demands" and viewed as strategies individuals use to optimize their job characteristics. We hypothesized that daily job crafting relates to daily job demands and resources (work pressure and autonomy), which consequently relate to daily work engagement and exhaustion and ultimately to job performance. A sample of 95 employees filled in a quantitative diary for 5 consecutive working days (n occasions = 475). We predicted and found that daily seeking resources was positively associated with daily task performance because daily autonomy and work engagement increased. In contrast, daily reducing demands was detrimental for daily task performance and altruism, because employees lower their daily workload and consequently their engagement and exhaustion, respectively. Only daily seeking challenges was positively (rather than negatively) associated with daily counterproductive behavior. We conclude that employee job crafting can have both beneficial and detrimental effects on job performance. (c) 2015 APA, all rights reserved).

  14. Global scale modeling of riverine sediment loads: tropical rivers in a global context

    NASA Astrophysics Data System (ADS)

    Cohen, Sagy; Syvitski, James; Kettner, Albert

    2015-04-01

    A global scale riverine sediment flux model (termed WBMsed) is introduced. The model predicts spatially and temporally explicit water, suspended sediment and nutrients flux in relatively high resolutions (6 arc-min and daily). Modeled riverine suspended sediment flux through global catchments is used in conjunction with observational data for 35 tropical basins to highlight key basin scaling relationships. A 50 year, daily model simulation illuminates how precipitation, relief, lithology and drainage basin area affect sediment load, yield and concentration. Tropical river systems, wherein much of a drainage basin experiences tropical climate are strongly influenced by the annual and inter-annual variations of the Inter-tropical Convergence Zone (ITCZ) and its derivative monsoonal winds, have comparatively low inter-annual variation in sediment yield. Rivers draining rainforests and those subjected to tropical monsoons typically demonstrate high runoff, but with notable exceptions. High rainfall intensities from burst weather events are common in the tropics. The release of rain-forming aerosols also appears to uniquely increase regional rainfall, but its geomorphic manifestation is hard to detect. Compared to other more temperate river systems, climate-driven tropical rivers do not appear to transport a disproportionate amount of particulate load to the world's oceans, and their warmer, less viscous waters are less competent. Multiple-year hydrographs reveal that seasonality is a dominant feature of most tropical rivers, but the rivers of Papua New Guinea are somewhat unique being less seasonally modulated. Local sediment yield within the Amazon is highest near the Andes, but decreases towards the ocean as the river's discharge is diluted by water influxes from sediment-deprived rainforest tributaries

  15. Insufficient cure under the condition of high irradiance and short irradiation time.

    PubMed

    Feng, Li; Carvalho, Ricardo; Suh, Byoung I

    2009-03-01

    To investigate if and why a plasma arc curing (PAC) light tends to undercure methacrylate-based resins or resin composites. Model dimethacrylate resins, commercial dental adhesives, and commercial resin composites were cured using a PAC light and a halogen light with the similar radiant exposures but different combinations of irradiance and irradiation time. The degree of double bond conversion (DC) was measured with FTIR spectroscopy and analyzed as a function of radiant exposure. The PAC light produced a lower DC than the halogen light for the model resin with the lowest viscosity and for three of the four adhesives. With a high irradiance, the PAC light could cure three of the four composites as thoroughly as its halogen counterpart. When the irradiance was reduced, however, three composites yielded a lower DC. Insufficient cure by PAC lights or any curing lights with very high irradiance is likely to happen when too short an irradiation time is used. It is because under higher irradiance, the lifetime of free radicals is shorter.

  16. Analysis of the global ISCCP TOVS water vapor climatology

    NASA Technical Reports Server (NTRS)

    Wittmeyer, Ian L.; Vonder Haar, Thomas H.

    1994-01-01

    A climatological examination of the global water vapor field based on a multiyear period of successfull satellite-based observations is presented. Results from the multiyear global ISCCP TIROS Operational Vertical Sounder (TOVS) water vapor dataset as operationally produced by NESDIS and ISCCP are shown. The methods employed for the retrieval of precipitable water content (PWC) utilize infrared measurements collected by the TOVS instrument package flown aboard the NOAA series of operational polar-orbiting satellites. Strengths of this dataset include the nearly global daily coverage, availability for a multiyear period, operational internal quality checks, and its description of important features in the mean state of the atmosphere. Weaknesses of this PWC dataset include that the infrared sensors are unable to collect data in cloudy regions, the retrievals are strongly biased toward a land-based radiosonde first-guess dataset, and the description of high spatial and temporal variability is inadequate. Primary consequences of these factors are seen in the underestimation of ITCZ water vapor maxima, and underestimation of midlatitude water vapor mean and standard deviation values where transient atmospheric phenomena contribute significantly toward time means. A comparison of TOVS analyses to SSM/I data over ocean for the month of July 1988 shows fair agreement in the magnitude and distribution of the monthly mean values, but the TOVS fields exhibit much less temporal and spatial variability on a daily basis in comparison to the SSM/I analyses. The emphasis of this paper is on the presentation and documentation of an early satellite-based water vapor climatology, and description of factors that prevent a more accurate representation of the global water vapor field.

  17. Chronic Daily Headaches

    MedlinePlus

    ... headache New daily persistent headache Hemicrania continua Chronic migraine This type typically occurs in people with a history of episodic migraines. Chronic migraines tend to: Affect one side or ...

  18. Extending the Precipitation Map Offshore Using Daily and 3-Hourly Combined Precipitation Estimates

    NASA Technical Reports Server (NTRS)

    Huffman, George J.; Adler, Robert F.; Bolvin, David T.; Curtis, Scott; Einaudi, Franco (Technical Monitor)

    2001-01-01

    One of the difficulties in studying landfalling extratropical cyclones along the Pacific Coast is the lack of antecedent data over the ocean, including precipitation. Recent research on combining various satellite-based precipitation estimates opens the possibility of realistic precipitation estimates on a global 1 deg. x 1 deg. latitude-longitude grid at the daily or even 3-hourly interval. The goal in this work is to provide quantitative precipitation estimates that correctly represent the precipitation- related variables in the hydrological cycle: surface accumulations (fresh-water flux into oceans), frequency and duration statistics, net latent heating, etc.

  19. Effect of Gamma Ray Irradiation on Interlaminar Shear Strength of Glass Fiber Reinforced Plastics at 77 K

    NASA Astrophysics Data System (ADS)

    Nishimura, A.; Nishijima, S.; Izumi, Y.

    2008-03-01

    It is known that an organic material is damaged by gamma ray irradiation, and the strength after irradiation has dependence on the gamma ray dose. These issues are important not only to make global understanding of electric insulating performance of glass fiber reinforced plastics (GFRP) under irradiation condition but also to develop new insulation materials. This paper presents the dependence of fracture mode and interlaminar shear strength (ILSS) on the material and the gamma ray irradiation effect on the fracture mode and the ILSS. 6 mm radius loading nose and supports were used to prompt ILS fracture for a short beam test. A 2.5 mm thick small specimen machined out of a 13 mm thick G-10CR GFRP plate (sliced specimen) showed lower ILSS and translaminar shear (TLS) fracture, although the same size specimen prepared from a 2.5 mm G-10CR GFRP plate (non-sliced specimen) showed ILS fracture and the higher ILSS. Both type of specimens showed the degradation of ILSS after gamma ray irradiation. The fracture mode of the non-sliced specimen changed from ILS to TLS fracture and no bending fracture was observed. The resistance to shear deformation of glass cloth/epoxy laminate structure would be damaged by the irradiation.

  20. Integrated safety and efficacy analysis of once-daily fluticasone furoate for the treatment of asthma.

    PubMed

    O'Byrne, Paul M; Jacques, Loretta; Goldfrad, Caroline; Kwon, Namhee; Perrio, Michael; Yates, Louisa J; Busse, William W

    2016-11-24

    Fluticasone furoate is a once-daily inhaled corticosteroid. This report provides an overview of safety and efficacy data that support the use of once-daily fluticasone furoate 100 μg or 200 μg in adult and adolescent asthma patients. Fourteen clinical studies (six Phase II and eight Phase III) were conducted as part of the fluticasone furoate global clinical development programme in asthma. Safety data from 10 parallel-group, randomised, double-blind Phase II and III studies (including 3345 patients who received at least one dose of fluticasone furoate) were integrated to provide information on adverse events, withdrawals, laboratory assessments, vital signs and hypothalamic-pituitary-adrenal axis function. The efficacy of once-daily fluticasone furoate was evaluated in all included studies. Once-daily fluticasone furoate 100 μg and 200 μg safety profiles were consistent with those reported for other inhaled corticosteroids, and both doses consistently demonstrated efficacy versus placebo. In the integrated analysis, no dose-response relationship was observed for the overall incidence of adverse events and there were no significant effects of fluticasone furoate on hypothalamic-pituitary-adrenal axis function. Once-daily fluticasone furoate 100 μg and 200 μg had acceptable safety profiles and was efficacious in adult and adolescent patients with asthma. There was no evidence of cortisol suppression at studied doses. GSK (NCT01499446/FFA20001, NCT00398645/FFA106783, NCT00766090/112202, NCT00603746/FFA109684, NCT00603278/FFA109685, NCT00603382/FFA109687, NCT01436071/115283, NCT01436110/115285, NCT01159912/112059, NCT01431950/114496, NCT01165138/HZA106827, NCT01086384/106837, NCT01134042/HZA106829 and NCT01244984/1139879).

  1. Measuring Daily Stress in Children.

    ERIC Educational Resources Information Center

    Parfenoff, Sheila H.; Jose, Paul E.

    A study of school-age children was designed to: (1) identify hassles that children experience in their families, among peers, and at school; (2) determine the ability of hassles to predict unhealthy psychological and physical functioning; and (3) explore the effect of daily hassles on school behavior. A measure of children's daily stress that used…

  2. Digital Daily Cycles of Individuals

    NASA Astrophysics Data System (ADS)

    Aledavood, Talayeh; Lehmann, Sune; Saramäki, Jari

    2015-10-01

    Humans, like almost all animals, are phase-locked to the diurnal cycle. Most of us sleep at night and are active through the day. Because we have evolved to function with this cycle, the circadian rhythm is deeply ingrained and even detectable at the biochemical level. However, within the broader day-night pattern, there are individual differences: e.g., some of us are intrinsically morning-active, while others prefer evenings. In this article, we look at digital daily cycles: circadian patterns of activity viewed through the lens of auto-recorded data of communication and online activity. We begin at the aggregate level, discuss earlier results, and illustrate differences between population-level daily rhythms in different media. Then we move on to the individual level, and show that there is a strong individual-level variation beyond averages: individuals typically have their distinctive daily pattern that persists in time. We conclude by discussing the driving forces behind these signature daily patterns, from personal traits (morningness/eveningness) to variation in activity level and external constraints, and outline possibilities for future research.

  3. Assessment of Histological Remission in Ulcerative Colitis: Discrepancies Between Daily Practice and Expert Opinion.

    PubMed

    Römkens, Tessa E H; Kranenburg, Pim; Tilburg, Arjan van; Bronkhorst, Carolien; Nagtegaal, Iris D; Drenth, Joost P H; Hoentjen, Frank

    2018-03-28

    Histological remission [HR] is a potential treatment target in ulcerative colitis [UC]. Limited 'real world' data are available on the reliability of histological scoring when assessing minimal histological inflammation. The aim of this study was to investigate the reliability of UC histological scores in colonic biopsies showing mucosal healing [MH] and limited histological inflammation, and to compare the 'daily practice' histological assessment with expert reviews by gastrointestinal [GI] pathologists. We performed a retrospective single-centre study. Colonic biopsies from UC patients with MH [Mayo score ≤ 1] were included. All biopsies assessed in daily practice were reassessed by three blinded GI pathologists using three histological scores (Geboes score [GS], Riley score [RS], Harpaz [Gupta] Index [HGI]) and a global visual scale [GVS]. We evaluated inter- and intra-observer variation between GI pathologists and correlations between scores including the initial histological assessment using Cronbach's alpha and Spearman rho analysis. In total, 270 biopsies from 39 UC patients were included. The inter-observer concordance for all histological indexes was substantial to almost perfect [GS 0.84; HGI 0.61; GVS 0.74, RS 0.91]. Correlation between the RS and GS was almost perfect [R = 0.86], but we found no correlation between the primary histological assessment and reassessment by GI pathologists. Current UC histological scores reliably assess limited histological inflammation in UC patients. The discrepancy between the initial histological assessment and the reassessment by dedicated GI pathologists suggests a gap between daily practice and academic expertise. This issue may limit the implementation of HR as a treatment target for UC in daily practice.

  4. Comparing daily drivers of problem drinking among older and younger adults: An electronic daily diary study using smartphones.

    PubMed

    Kuerbis, Alexis; Treloar Padovano, Hayley; Shao, Sijing; Houser, Jessica; Muench, Frederick J; Morgenstern, Jon

    2018-02-01

    By 2030, numbers and proportions of older adults with substance-use problems are expected to increase. While risk factors for problem drinking in late life have been identified, it remains unknown whether these factors drive daily drinking among older problem drinkers. This study examined the daily drivers of drinking among problem drinkers, moderated by age, utilizing ecological momentary assessment (EMA). Participants (N = 139), ages 20-73, received daily EMA online surveys completed via a smartphone prior to initiation of treatment. Multilevel modeling tested the moderating impact of age on within- and between-person relationships between drinking and focal predictors (mood, loneliness, boredom, stress, poor sleep, social factors, alcohol salience, commitment and confidence not to drink heavily). Older adults reported greater alcohol consumption when daily boredom levels were higher. Heavier drinking among younger adults was associated with poorer sleep quality. Greater daily confidence, daily commitment and daily alcohol salience did not impact drinking to the same extent for older adults as for younger adults. Greater person-level commitment predicted reduced drinking equivalently across age, but low person-level commitment predicted greater drinking among older adults compared to their younger counterparts. Older adults may have unique daily drivers of drinking that are not fully realized in current research and intervention efforts. Addressing the growing substance-use treatment needs among this population will require identifying the unique drivers of drinking among older adults, such as boredom, when compared to younger adults. Copyright © 2018 Elsevier B.V. All rights reserved.

  5. Changes in surface solar UV irradiances and total ozone during the solar eclipse of August 11, 1999

    NASA Astrophysics Data System (ADS)

    Zerefos, C. S.; Balis, D. S.; Meleti, C.; Bais, A. F.; Tourpali, K.; Kourtidis, K.; Vanicek, K.; Cappellani, F.; Kaminski, U.; Colombo, T.; Stübi, R.; Manea, L.; Formenti, P.; Andreae, M. O.

    2000-11-01

    During the solar eclipse of August 11, 1999, intensive measurements of UV solar irradiance and total ozone were performed at a number of observatories located near the path of the Moon's shadow. At the Laboratory of Atmospheric Physics (LAP) of the Aristotle University of Thessaloniki, Greece, global and direct spectra of UV solar irradiances (285-365 nm) were recorded with a double monochromator, and erythemal irradiances were measured with broadband pyranometers. In addition, higher-frequency measurements of global and direct irradiances at six UV wavelengths were performed with a single Brewer spectrophotometer. Total ozone measurements were also performed with Dobson and Brewer spectrophotometers at Hradec Kralove (Czech Republic), Ispra (Italy), Sestola (Italy), Hohenpeissenberg (Germany), Bucharest (Romania), Arosa (Switzerland), and Thessaloniki (Greece). From the spectral UV measurements the limb darkening effect of the solar disk was tentatively quantified from differences of measured solar spectral irradiances at the peak of the eclipse (near to limb conditions) and before the eclipse. Two blackbody curves were fit to the preeclipse and peak eclipse spectra, which have shown a difference in effective temperatures of about 165°K between the limb and the whole of the solar disk. The limb darkening effect is larger at the shorter UV wavelengths. The ratio of the diffuse to direct solar irradiances during the eclipse shows that the diffuse component is reduced much less compared to the decline of the direct solar irradiance at the shorter wavelengths. Moreover, a 20-min oscillation of erythemal UV-B solar irradiance was observed before and after the time of the eclipse maximum under clear skies, indicating a possible 20-min fluctuation in total ozone, presumably caused by the eclipse-induced gravity waves. This work also shows that routine total ozone measurements with a Brewer or a Dobson spectrophotometer should be used with caution during a solar eclipse

  6. "Self-critical perfectionism, daily stress, and disclosure of daily emotional events": Correction to Richardson and Rice (2015).

    PubMed

    2016-01-01

    Reports an error in "Self-critical perfectionism, daily stress, and disclosure of daily emotional events" by Clarissa M. E. Richardson and Kenneth G. Rice (Journal of Counseling Psychology, 2015[Oct], Vol 62[4], 694-702). In the article, the labels of the two lines in Figure 1 were inadvertently transposed. The dotted line should be labeled High SCP and the solid line should be labeled Low SCP. The correct version is present in the erratum. (The following abstract of the original article appeared in record 2015-30890-001.) Although disclosure of stressful events can alleviate distress, self-critical perfectionism may pose an especially strong impediment to disclosure during stress, likely contributing to poorer psychological well-being. In the current study, after completing a measure of self-critical perfectionism (the Discrepancy subscale of the Almost Perfect Scale-Revised; Slaney, Rice, Mobley, Trippi, & Ashby, 2001), 396 undergraduates completed measures of stress and disclosure at the end of each day for 1 week. Consistent with hypotheses and previous research, multilevel modeling results indicated significant intraindividual coupling of daily stress and daily disclosure where disclosure was more likely when experiencing high stress than low stress. As hypothesized, Discrepancy moderated the relationship between daily stress and daily disclosure. Individuals higher in self-critical perfectionism (Discrepancy) were less likely to engage in disclosure under high stress, when disclosure is often most beneficial, than those with lower Discrepancy scores. These results have implications for understanding the role of stress and coping in the daily lives of self-critical perfectionists. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

  7. DREAMS-SIS: The Solar Irradiance Sensor on-board the ExoMars 2016 lander

    NASA Astrophysics Data System (ADS)

    Arruego, I.; Apéstigue, V.; Jiménez-Martín, J.; Martínez-Oter, J.; Álvarez-Ríos, F. J.; González-Guerrero, M.; Rivas, J.; Azcue, J.; Martín, I.; Toledo, D.; Gómez, L.; Jiménez-Michavila, M.; Yela, M.

    2017-07-01

    The Solar Irradiance Sensor (SIS) was part of the DREAMS (Dust characterization, Risk assessment, and Environment Analyzer on the Martian Surface) payload package on board the ExoMars 2016 Entry and Descent Module (EDM), "Schiaparelli". DREAMS was a meteorological station aimed at the measurement of several atmospheric parameters, as well as the presence of electric fields, during the surface operations of EDM. DREAMS-SIS is a highly miniaturized lightweight sensor designed for small meteorological stations, capable of estimating the aerosol optical depth (AOD) several times per sol, as well as performing a direct measurement of the global (direct plus scattered) irradiance on the Martian surface in the spectral range between 200 and 1100 nm. AOD is estimated from the irradiance measurements at two different spectral bands - Ultraviolet (UV) and near infrared (NIR) - which also enables color index (CI) analysis for the detection of clouds. Despite the failure in the landing of Schiaparelli, DREAMS-SIS is a valuable precursor for new developments being carried-on at present. The concept and design of DREAMS-SIS are here presented and its operating principles, supported by preliminary results from a short validation test, are described. Lessons learnt and future work towards a new generation of Sun irradiance sensors is also outlined.

  8. Maintenance of heartburn relief after step-down from twice-daily proton pump inhibitor to once-daily dexlansoprazole modified release.

    PubMed

    Fass, Ronnie; Inadomi, John; Han, Cong; Mody, Reema; O'Neil, Janet; Perez, M Claudia

    2012-03-01

    Many patients with gastroesophageal reflux disease (GERD) take a proton pump inhibitor (PPI) twice daily to control symptoms. Once-daily dexlansoprazole modified release (MR) has a dual-delayed release formulation, making it attractive for step-down management of patients whose symptoms are well controlled on twice-daily PPIs. We investigated whether step-down to once-daily dexlansoprazole controls heartburn in patients with GERD who were receiving twice-daily PPI therapy. Patients 18 years and older taking a twice-daily PPI for symptom control were enrolled (n = 178) in a single-blind, multicenter study; 163 patients completed the study and 142 patients met criteria for the efficacy analysis. During the 6-week screening and treatment periods, patients recorded the presence of heartburn symptoms twice daily in electronic diaries. Patients' heartburn was considered well controlled if they had an average of 1 symptom or fewer per week during the last 4 weeks of screening and treatment. After screening, qualified patients were switched to masked dexlansoprazole MR 30 mg and placebo for 6 weeks. The primary efficacy end point was the proportion of patients whose heartburn remained well controlled after step-down. GERD-related symptoms and quality of life (QOL) also were evaluated using the Patient Assessment of Upper Gastrointestinal Disorders Symptom Severity Index (PAGI-SYM) and the PAGI-QOL questionnaires, respectively. After step-down to once-daily dexlansoprazole MR 30 mg, heartburn remained well controlled in 88% of patients (125 of 142). These patients were able to maintain their GERD-related symptom severity and QOL, indicated by marginal changes in the PAGI-SYM and PAGI-QOL total and subscale scores, respectively. Most patients with GERD who take twice-daily PPI to control heartburn are able to successfully step down to once-daily dexlansoprazole 30 mg. Copyright © 2012 AGA Institute. Published by Elsevier Inc. All rights reserved.

  9. Effects of wearing a daily disposable lens on tear film: a randomised controlled trial.

    PubMed

    Chong, Pamela Qin Yi; Yeo, Sharon; Too, Cheah Loon; Boo, Cynthia; Tong, Louis

    2016-05-01

    Contact lens-induced dry eye is commonly encountered, although its extent is not well documented with daily disposable lenses. A novel type of contact lens system incorporating moisturising agent (alginic acid) has been developed. The aim of this study was to evaluate the effect of wearing daily 2-hydroxyethyl methacrylate disposable contact lenses for seven days on tear stability, conjunctival and limbal redness and dry eye symptoms. Then, we aimed to determine whether lens solutions containing alginic acid had any influence on tear parameters. This was a seven-day parallel group double-masked clinical trial of previous contact lens wearers, where participants were randomly assigned to wearing SEED 1dayPure moisture contact lenses with (n = 15) or without alginic acid (n = 15). Tear lipid layer thickness (LLT), non-invasive tear break-up time (NIBUT), conjunctival redness, corneal fluorescein staining, tear break-up time and Schirmer I readings were measured. Symptom severity and frequency were evaluated and combined using a global score from visual analogue scales. The mean age and standard deviation of the participants was 25 ± 3.8 years. There were 24 females and six males. After reintroduction of contact lens wear for one week, there was significant improvement in the global symptom score; however, this may not be clinically significant. There were small and clinically insignificant changes in limbal and conjunctival hyperaemia but no significant changes in lipid layer thickness, Schirmer I and NIBUT in overall participants. The use of alginic acid in lens solutions did not affect these parameters compared to control lenses (p > 0.05). After seven days of wearing a modern daily disposable lens, there was no significant deterioration of tear function in a group of young contact lens wearers. In this short-term study, there was no evidence of significant benefit of lens solutions containing alginic acid used with HEMA lenses. © 2016 The Authors Clinical and

  10. Nicaraven reduces cancer metastasis to irradiated lungs by decreasing CCL8 and macrophage recruitment.

    PubMed

    Yan, Chen; Luo, Lan; Urata, Yoshishige; Goto, Shinji; Li, Tao-Sheng

    2018-04-01

    Radiotherapy for cancer patients damages normal tissues, thereby inducing an inflammatory response and promoting cancer metastasis. We investigated whether nicaraven, a compound with radioprotective and anti-inflammatory properties, could attenuate radiation-induced cancer metastasis to the lungs of mice. Nicaraven and amifostine, another commercial radioprotective agent, had limited effects on both the radiosensitivity of Lewis lung carcinoma cells in vitro and radiation-induced tumor growth inhibition in vivo. Using experimental and spontaneous metastasis models, we confirmed that thorax irradiation with 5 Gy X-rays dramatically increased the number of tumors in the lungs. Interestingly, the number of tumors in the lungs was significantly reduced by administering nicaraven but not by administering amifostine daily after radiation exposure. Furthermore, nicaraven administration effectively inhibited CCL8 expression and macrophage recruitment in the lungs 1 day after thorax irradiation. Our data suggest that nicaraven attenuates radiation-induced lung metastasis, likely by regulating the inflammatory response after radiation exposure. Copyright © 2018 Elsevier B.V. All rights reserved.

  11. Gamma-irradiated β-glucan modulates signaling molecular targets of hepatocellular carcinoma in rats.

    PubMed

    Elsonbaty, Sawsan M; Zahran, Walid E; Moawed, Fatma Sm

    2017-08-01

    β-glucans are one of the most abundant forms of polysaccharides known as biological response modifiers which influence host's biological response and stimulate immune system. Accordingly, this study was initiated to evaluate irradiated β-glucan as a modulator for cellular signaling growth factors involved in the pathogenesis of hepatocellular carcinoma in rats. Hepatocellular carcinoma was induced with 20 mg diethylnitrosamine/kg BW. Rats received daily by gastric gavage 65 mg irradiated β-glucan/kg BW. It was found that treatment of rats with diethylnitrosamine induced hepatic injury and caused significant increase in liver injury markers with a concomitant significant increase in both hepatic oxidative and inflammatory indices: alpha-fetoprotein, interferon gamma, and interleukin 6 in comparison with normal and irradiated β-glucan-treated groups. Western immunoblotting showed a significant increase in the signaling growth factors: extracellular signal-regulated kinase 1 and phosphoinositide 3-kinase proteins in a diethylnitrosamine-treated group while both preventive and therapeutic irradiated β-glucan treatments recorded significant improvement versus diethylnitrosamine group via the modulation of growth factors that encounters hepatic toxicity. The transcript levels of vascular endothelial growth factor A and inducible nitric oxide synthase genes were significantly higher in the diethylnitrosamine-treated group in comparison with controls. Preventive and therapeutic treatments with irradiated β-glucan demonstrated that the transcript level of these genes was significantly decreased which demonstrates the protective effect of β-glucan. Histological investigations revealed that diethylnitrosamine treatment affects the hepatic architecture throughout the significant severe appearance of inflammatory cell infiltration in the portal area and congestion in the portal vein in association with severe degeneration and dysplasia in hepatocytes all over hepatic

  12. Conversion from twice-daily tacrolimus to once-daily extended release tacrolimus (LCPT): the phase III randomized MELT trial.

    PubMed

    Bunnapradist, S; Ciechanowski, K; West-Thielke, P; Mulgaonkar, S; Rostaing, L; Vasudev, B; Budde, K

    2013-03-01

    Phase III noninferiority trial examining efficacy and safety of converting stable renal transplant recipients from twice-daily tacrolimus to a novel extended-release once-daily tacrolimus formulation (LCPT) with a controlled agglomeration technology. Controls maintained tacrolimus twice daily. The primary efficacy endpoint was proportion of patients with efficacy failures (death, graft failure, locally read biopsy-proven acute rejection [BPAR], or loss to follow-up) within 12 months. Starting LCPT dose was 30% lower (15% for blacks) than preconversion tacrolimus dose; target trough levels were 4-15 ng/mL. A total of 326 patients were randomized; the mITT population (n = 162 each group) was similar demographically in the two groups. Mean daily dose of LCPT was significantly (p < 0.0001) lower than preconversion tacrolimus dose at each visit; mean trough levels between groups were similar. There were four efficacy failures in each group; safety outcomes were similar between groups. Frequency of premature study drug discontinuation was LCPT: 12% versus tacrolimus twice daily: 5% (p = 0.028). LCPT demonstrated noninferiority to tacrolimus twice daily in efficacy failure rates. LCPT may offer a safe and effective alternative for converting patients to a once-daily formulation. Compared to currently available tacrolimus formulation, LCPT requires lower doses to achieve target trough levels. © Copyright 2012 The American Society of Transplantation and the American Society of Transplant Surgeons.

  13. 27 CFR 19.740 - Daily storage records.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Daily storage records. 19..., DEPARTMENT OF THE TREASURY LIQUORS DISTILLED SPIRITS PLANTS Records and Reports Storage Account § 19.740 Daily storage records. (a) General. Proprietors shall maintain daily records in the storage account...

  14. Proton irradiation of simple gas mixtures: Influence of irradiation parameters

    NASA Technical Reports Server (NTRS)

    Sack, Norbert J.; Schuster, R.; Hofmann, A.

    1990-01-01

    In order to get information about the influence of irradiation parameters on radiolysis processes of astrophysical interest, methane gas targets were irradiated with 6.5 MeV protons at a pressure of 1 bar and room temperature. Yields of higher hydrocarbons like ethane or propane were found by analysis of irradiated gas samples using gas chromatography. The handling of the proton beam was of great experimental importance for determining the irradiation parameters. In a series of experiments current density of the proton beam and total absorbed energy were shown to have a large influence on the yields of produced hydrocarbons. Mechanistic interpretations of the results are given and conclusions are drawn with regard to the chemistry and the simulation of various astrophysical systems.

  15. Simulating PACE Global Ocean Radiances

    NASA Technical Reports Server (NTRS)

    Gregg, Watson W.; Rousseaux, Cecile S.

    2017-01-01

    The NASA PACE mission is a hyper-spectral radiometer planned for launch in the next decade. It is intended to provide new information on ocean biogeochemical constituents by parsing the details of high resolution spectral absorption and scattering. It is the first of its kind for global applications and as such, poses challenges for design and operation. To support pre-launch mission development and assess on-orbit capabilities, the NASA Global Modeling and Assimilation Office has developed a dynamic simulation of global water-leaving radiances, using an ocean model containing multiple ocean phytoplankton groups, particulate detritus, particulate inorganic carbon (PIC), and chromophoric dissolved organic carbon (CDOC) along with optical absorption and scattering processes at 1 nm spectral resolution. The purpose here is to assess the skill of the dynamic model and derived global radiances. Global bias, uncertainty, and correlation are derived using available modern satellite radiances at moderate spectral resolution. Total chlorophyll, PIC, and the absorption coefficient of CDOC (aCDOC), are simultaneously assimilated to improve the fidelity of the optical constituent fields. A 5-year simulation showed statistically significant (P < 0.05) comparisons of chlorophyll (r = 0.869), PIC (r = 0.868), and a CDOC (r =0.890) with satellite data. Additionally, diatoms (r = 0.890), cyanobacteria (r = 0.732), and coccolithophores (r = 0.716) were significantly correlated with in situ data. Global assimilated distributions of optical constituents were coupled with a radiative transfer model (Ocean-Atmosphere Spectral Irradiance Model, OASIM) to estimate normalized water-leaving radiances at 1 nm for the spectral range 250-800 nm. These unassimilated radiances were within 0.074 mW/sq cm/micron/sr of MODIS-Aqua radiances at 412, 443, 488, 531, 547, and 667 nm. This difference represented a bias of 10.4% (model low). A mean correlation of 0.706 (P < 0.05) was found with global

  16. Simulating PACE Global Ocean Radiances

    PubMed Central

    Gregg, Watson W.; Rousseaux, Cécile S.

    2017-01-01

    The NASA PACE mission is a hyper-spectral radiometer planned for launch in the next decade. It is intended to provide new information on ocean biogeochemical constituents by parsing the details of high resolution spectral absorption and scattering. It is the first of its kind for global applications and as such, poses challenges for design and operation. To support pre-launch mission development and assess on-orbit capabilities, the NASA Global Modeling and Assimilation Office has developed a dynamic simulation of global water-leaving radiances, using an ocean model containing multiple ocean phytoplankton groups, particulate detritus, particulate inorganic carbon (PIC), and chromophoric dissolved organic carbon (CDOC) along with optical absorption and scattering processes at 1 nm spectral resolution. The purpose here is to assess the skill of the dynamic model and derived global radiances. Global bias, uncertainty, and correlation are derived using available modern satellite radiances at moderate spectral resolution. Total chlorophyll, PIC, and the absorption coefficient of CDOC (aCDOC), are simultaneously assimilated to improve the fidelity of the optical constituent fields. A 5-year simulation showed statistically significant (P <0.05) comparisons of chlorophyll (r = 0.869), PIC (r = 0.868), and aCDOC (r = 0.890) with satellite data. Additionally, diatoms (r = 0.890), cyanobacteria (r = 0.732), and coccolithophores (r = 0.716) were significantly correlated with in situ data. Global assimilated distributions of optical constituents were coupled with a radiative transfer model (Ocean-Atmosphere Spectral Irradiance Model, OASIM) to estimate normalized water-leaving radiances at 1 nm for the spectral range 250–800 nm. These unassimilated radiances were within −0.074 mW cm−2 μm1 sr−1 of MODIS-Aqua radiances at 412, 443, 488, 531, 547, and 667 nm. This difference represented a bias of −10.4% (model low). A mean correlation of 0.706 (P < 0.05) was found with

  17. KEY RESULTS FROM IRRADIATION AND POST-IRRADIATION EXAMINATION OF AGR-1 UCO TRISO FUEL

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Demkowicz, Paul A.; Hunn, John D.; Petti, David A.

    The AGR-1 irradiation experiment was performed as the first test of tristructural isotropic (TRISO) fuel in the US Advanced Gas Reactor Fuel Development and Qualification Program. The experiment consisted of 72 right cylinder fuel compacts containing approximately 3×105 coated fuel particles with uranium oxide/uranium carbide (UCO) fuel kernels. The fuel was irradiated in the Advanced Test Reactor for a total of 620 effective full power days. Fuel burnup ranged from 11.3 to 19.6% fissions per initial metal atom and time average, volume average irradiation temperatures of the individual compacts ranged from 955 to 1136°C. This paper focuses on key resultsmore » from the irradiation and post-irradiation examination, which revealed a robust fuel with excellent performance characteristics under the conditions tested and have significantly improved the understanding of UCO coated particle fuel irradiation behavior within the US program. The fuel exhibited a very low incidence of TRISO coating failure during irradiation and post-irradiation safety testing at temperatures up to 1800°C. Advanced PIE methods have allowed particles with SiC coating failure to be isolated and meticulously examined, which has elucidated the specific causes of SiC failure in these specimens. The level of fission product release from the fuel during irradiation and post-irradiation safety testing has been studied in detail. Results indicated very low release of krypton and cesium through intact SiC and modest release of europium and strontium, while also confirming the potential for significant silver release through the coatings depending on irradiation conditions. Focused study of fission products within the coating layers of irradiated particles down to nanometer length scales has provided new insights into fission product transport through the coating layers and the role various fission products may have on coating integrity. The broader implications of these results and the application

  18. The ability of filgrastim to mitigate mortality following LD50/60 total-body irradiation is administration time-dependent

    PubMed Central

    Farese, AM; Brown, CR; Smith, CP; Gibbs, AM; Katz, B P; Johnson, CS; Prado, K; MacVittie, TJ

    2013-01-01

    The identification of the optimal administration schedule for an effective medical countermeasure is critical for the effective treatment of individuals exposed to potentially lethal doses of radiation. The efficacy of filgrastim (Neupogen®), a potential medical countermeasure, to improve survival when initiated at 48 hours following total body irradiation in a nonhuman primate model of the hematopoietic syndrome of the acute radiation syndrome was investigated. Animals were exposed to total body irradiation, antero-posterior exposure, total midline tissue dose of 7.5 Gray, (target lethal dose 50/60) delivered at 0.80 Gray minute-1, using linear accelerator-derived 6 Megavolt photons. All animals were administered medical management. Following irradiation on day 0, filgrastim (10 μg kg day-1) or the control (5% dextrose in water) was administered subcutaneously, daily through effect (absolute neutrophil count ≥ 1,000 cells μL-1 for 3 consecutive days). The study (n = 80) was powered to demonstrate a 25% improvement in survival following the administration of filgrastim or control beginning at 48 ± 4 hours post-irradiation. Survival analysis was conducted on the intention-to-treat population using a two-tailed null hypothesis at a 5% significance level. Filgrastim, initiated 48 hours after irradiation, did not improve survival (2.5% increase, P = 0.8230). These data demonstrate that efficacy of a countermeasure to mitigate lethality in the hematopoietic syndrome of the acute radiation syndrome can be dependent on the interval between irradiation and administration of the medical countermeasure. PMID:24276548

  19. Interleukin-1 modulatory effect on the action of chemotherapeutic drugs and localized irradiation of the lip, duodenum, and tumor

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Zaghloul, M.S.; Dorie, M.J.; Kallman, R.F.

    1993-06-15

    This study was conducted to examine the radioprotective and radiochemoprotective capabilities of interleukin 1[beta] (IL-1) on two acute-reacting normal tissues of the C3H mouse, the mucosa of the lip and the duodenum. Also assessed was the modulating effect of IL-1 on tumor growth in the same strain of mice. IL-1 was administered to C3H-Km mice in combination with fractionated irradiation, or with cyclophosphamide, cisplatin, or 5-fluorouracil (5FU) followed by irradiation. Normal tissue damage was evaluated in the mouse lip, using a subjective scoring system for tissue reaction, and in the duodenum, using the crypt cell survival assay. RIF-1 fibrosarcoma tumormore » response was assayed with the regrowth delay method. IL-1 protected against the acute reaction produced by fractionated irradiation in the lip mucosa, shifting the dose-response curve by 3.8 Gy. IL-1 was protective when injected intraperitoneally 24 hr before CY or c-DDP, which were given immediately before the first of five daily radiation dose fractions. The dose-response curves for cyclophosphamide and cisplatin were shifted 4.0 Gy and 1.6 Gy, respectively. IL-1 did not protect against 5FU toxicity when treatments were administered in that same sequence; however, when 5FU was given 4 or 8 hr before IL-1 and the first radiation dose fraction followed 20 or 16 hr later, there was significant protection and the curves were separated by 1.5 Gy or 3.5 Gy. IL-1 also protected duodenal crypt cells against the cytocidal effect of fractionated irradiation, with a dose difference of 1.5 Gy and an improvement of crypt survival of 11.7%. It was even more immediately before the first of five daily radiation doses, with the dose differences of 4.4 and 5.3 Gy, respectively, and improvements of crypt survival of 33.8 and 29.9%, respectively. There was no modification by IL-1 of the effect of irradiation alone on the RIF-1 tumor. 45 refs., 8 figs., 1 tab.« less

  20. Effects of UV-B irradiation on isoforms of antioxidant enzymes and their activities in red alga Grateloupia filicina (Rhodophyta)

    NASA Astrophysics Data System (ADS)

    Zhao, Jiqiang; Li, Lixia

    2014-11-01

    Macroalgae in a littoral zone are inevitably exposed to UV-B irradiance. We analyzed the effects of UV-B on isoenzyme patterns and activities of superoxide dismutase (SOD), peroxidase (POX), catalase (CAT), and ascorbate peroxidase (APX) of red algae Grateloupia filicina (Lamour.) C. Agardh. The activities of SOD, CAT, and APX changed in response to UV-B in a time- and dose-dependent manner. POX activity increased significantly under all three UV-B treatments. The enzymatic assay showed three distinct bands of SODI (Mn-SOD), SODII (Fe-SOD), and SODIII (CuZn-SOD) under a low (Luv) and medium (Muv) dose of UV-B irradiation, while SODI and SODIII activities decreased significantly when exposed to a high dose of UV-B irradiation (Huv). The activity of POX isoenzymes increased significantly after exposure to UV-B, which is consistent with the total activity. In addition, a clear decrease in activity of CATIV was detected in response to all the three doses of UV treatments. Some bands of APX isoenzyme were also clearly influenced by UV-B irradiation. Correspondingly, the daily growth rate declined under all the three exposure doses, and was especially significant under Muv and Huv treatments. These data suggest that, although the protection mechanisms of antioxidant defense system are partly inducible by UV-B to prevent the damage, G. filicina has incomplete tolerance to higher UV-B irradiation stress.

  1. The global SMOS Level 3 daily soil moisture and brightness temperature maps

    NASA Astrophysics Data System (ADS)

    Bitar, Ahmad Al; Mialon, Arnaud; Kerr, Yann H.; Cabot, François; Richaume, Philippe; Jacquette, Elsa; Quesney, Arnaud; Mahmoodi, Ali; Tarot, Stéphane; Parrens, Marie; Al-Yaari, Amen; Pellarin, Thierry; Rodriguez-Fernandez, Nemesio; Wigneron, Jean-Pierre

    2017-06-01

    The objective of this paper is to present the multi-orbit (MO) surface soil moisture (SM) and angle-binned brightness temperature (TB) products for the SMOS (Soil Moisture and Ocean Salinity) mission based on a new multi-orbit algorithm. The Level 3 algorithm at CATDS (Centre Aval de Traitement des Données SMOS) makes use of MO retrieval to enhance the robustness and quality of SM retrievals. The motivation of the approach is to make use of the longer temporal autocorrelation length of the vegetation optical depth (VOD) compared to the corresponding SM autocorrelation in order to enhance the retrievals when an acquisition occurs at the border of the swath. The retrieval algorithm is implemented in a unique operational processor delivering multiple parameters (e.g. SM and VOD) using multi-angular dual-polarisation TB from MO. A subsidiary angle-binned TB product is provided. In this study the Level 3 TB V310 product is showcased and compared to SMAP (Soil Moisture Active Passive) TB. The Level 3 SM V300 product is compared to the single-orbit (SO) retrievals from the Level 2 SM processor from ESA with aligned configuration. The advantages and drawbacks of the Level 3 SM product (L3SM) are discussed. The comparison is done on a global scale between the two datasets and on the local scale with respect to in situ data from AMMA-CATCH and USDA ARS Watershed networks. The results obtained from the global analysis show that the MO implementation enhances the number of retrievals: up to 9 % over certain areas. The comparison with the in situ data shows that the increase in the number of retrievals does not come with a decrease in quality, but rather at the expense of an increased time lag in product availability from 6 h to 3.5 days, which can be a limiting factor for applications like flood forecast but reasonable for drought monitoring and climate change studies. The SMOS L3 soil moisture and L3 brightness temperature products are delivered using an open licence and

  2. Rescue of CD8+ T cell vaccine memory following sublethal γ irradiation.

    PubMed

    McFarland, Hugh I; Berkson, Julia D; Lee, Jay P; Elkahloun, Abdel G; Mason, Karen P; Rosenberg, Amy S

    2015-07-31

    Sublethal γ irradiation eliminates CD8+ T cell mediated memory responses. In this work, we explored how these memory responses could be rescued in the aftermath of such exposure. We utilized two models of CD8+ T cell mediated immunity: a mouse model of Listeria monocytogenes (LM) infection in which CD8+ T cells specific for LM expressed antigens (Listeriolysin O, LLO) can be tracked, and a murine skin graft model in which CD8+ T cells mediate rejection across a MHC class I (D(d)) disparity. In the LM immunized mice, LL0 specific CD8+ T memory cells were lost on irradiation, preserved with rapid revaccination with an attenuated strain 1-3 days post-irradiation (PI), and these mice survived a subsequent wild type LM challenge. A genetic "signature of rescue" identified a group of immune-associated mRNA maintained or upregulated following irradiation and rescue. A number of these factors, including IL-36γ, dectin-2 (Clec4n), and mir101c are upregulated rapidly after exposure of mice to sublethal γ radiation alone and are sustained by early, but not later rescue. Such factors will be evaluated as potential therapeutics to replace individual vaccines for global rescue of CD8+ T memory cell responses following sublethal γ irradiation. The skin allograft model mirrored that of the LM model in that the accelerated D(d) skin allograft rejection response was lost in mice exposed to sublethal γ radiation, but infusion of allogeneic D(d) expressing bone marrow cells 1-4 days PI preserved the CD8+ T memory mediated accelerated rejection response, further suggesting that innate immune responses may not always be essential to rescue of CD8+ memory T cells following γ irradiation. Published by Elsevier Ltd.

  3. Global map of solar power production efficiency, considering micro climate factors

    NASA Astrophysics Data System (ADS)

    Hassanpour Adeh, E.; Higgins, C. W.

    2017-12-01

    Natural resources degradation and greenhouse gas emissions are creating a global crisis. Renewable energy is the most reliable option to mitigate this environmental dilemma. Abundancy of solar energy makes it highly attractive source of electricity. The existing global spatial maps of available solar energy are created with various models which consider the irradiation, latitude, cloud cover, elevation, shading and aerosols, and neglect the influence of local meteorological conditions. In this research, the influences of microclimatological variables on solar energy productivity were investigated with an in-field study at the Rabbit Hills solar arrays near Oregon State University. The local studies were extended to a global level, where global maps of solar power were produced, taking the micro climate variables into account. These variables included: temperature, relative humidity, wind speed, wind direction, solar radiation. The energy balance approach was used to synthesize the data and compute the efficiencies. The results confirmed that the solar power efficiency can be directly affected by the air temperature and wind speed.

  4. Climatology and Interannual Variability of Quasi-Global Intense Precipitation Using Satellite Observations

    NASA Technical Reports Server (NTRS)

    Ricko, Martina; Adler, Robert F.; Huffman, George J.

    2016-01-01

    Climatology and variations of recent mean and intense precipitation over a near-global (50 deg. S 50 deg. N) domain on a monthly and annual time scale are analyzed. Data used to derive daily precipitation to examine the effects of spatial and temporal coverage of intense precipitation are from the current Tropical Rainfall Measuring Mission (TRMM) Multisatellite Precipitation Analysis (TMPA) 3B42 version 7 precipitation product, with high spatial and temporal resolution during 1998 - 2013. Intense precipitation is defined by several different parameters, such as a 95th percentile threshold of daily precipitation, a mean precipitation that exceeds that percentile, or a fixed threshold of daily precipitation value [e.g., 25 and 50 mm day(exp -1)]. All parameters are used to identify the main characteristics of spatial and temporal variation of intense precipitation. High correlations between examined parameters are observed, especially between climatological monthly mean precipitation and intense precipitation, over both tropical land and ocean. Among the various parameters examined, the one best characterizing intense rainfall is a fraction of daily precipitation Great than or equal to 25 mm day(exp. -1), defined as a ratio between the intense precipitation above the used threshold and mean precipitation. Regions that experience an increase in mean precipitation likely experience a similar increase in intense precipitation, especially during the El Nino Southern Oscillation (ENSO) events. Improved knowledge of this intense precipitation regime and its strong connection to mean precipitation given by the fraction parameter can be used for monitoring of intense rainfall and its intensity on a global to regional scale.

  5. Improving the MODIS Global Snow-Mapping Algorithm

    NASA Technical Reports Server (NTRS)

    Klein, Andrew G.; Hall, Dorothy K.; Riggs, George A.

    1997-01-01

    An algorithm (Snowmap) is under development to produce global snow maps at 500 meter resolution on a daily basis using data from the NASA MODIS instrument. MODIS, the Moderate Resolution Imaging Spectroradiometer, will be launched as part of the first Earth Observing System (EOS) platform in 1998. Snowmap is a fully automated, computationally frugal algorithm that will be ready to implement at launch. Forests represent a major limitation to the global mapping of snow cover as a forest canopy both obscures and shadows the snow underneath. Landsat Thematic Mapper (TM) and MODIS Airborne Simulator (MAS) data are used to investigate the changes in reflectance that occur as a forest stand becomes snow covered and to propose changes to the Snowmap algorithm that will improve snow classification accuracy forested areas.

  6. A Global Precipitation Perspective on Persistent Extratropical Flow Anomalies

    NASA Technical Reports Server (NTRS)

    Huffman, George J.; Adler, Robert F.; Bolvin, David T.

    1999-01-01

    Two globally-complete, observation-only precipitation datasets have recently been developed for the Global Precipitation Climatology Project (GPCP). Both depend heavily on a variety of satellite input, as well as gauge data over land. The first, Version 2 x 79, provides monthly estimates on a 2.5 deg x 2.5 deg lat/long grid for the period 1979 through late 1999 (by the time of the conference). The second, the One-Degree Daily (1DD), provides daily estimates on a 1 deg x 1 deg grid for the period 1997 through late 1999 (by the time of the conference). Both are in beta test preparatory to release as official GPCP products. These datasets provide a unique perspective on the hydrological effects of the various atmospheric flow anomalies that have been identified by meteorologists. In this paper we discuss the regional precipitation effects that result from persistent extratropical flow anomalies. We will focus on the Pacific-North America (PNA) and North Atlantic Oscillation (NAO) patterns. Each characteristically becomes established on synoptic time scales, but then persists for periods that can exceed a month. The onset phase of each appears to have systematic mobile features, while the mature phase tend to be more stationary. Accordingly, composites of monthly data for outstanding positive and negative events (separately) contained in the 20-year record reveal the climatological structure of the precipitation during the mature phase. The climatological anomalies of the positive, negative, and (positive-negative) composites show the expected storm-track-related shifts in precipitation, and provide the advantage of putting the known precipitation effects over land in the context of the total pattern over land and ocean. As well, this global perspective points out some unexpected areas of correlation. Day-by-day composites of daily data anchored to the onset date demonstrate the systematic features during the onset. Although the 1DD has a fairly short record, some

  7. New daily persistent headache.

    PubMed

    Rozen, Todd D

    2010-01-01

    New daily persistent headache (NDPH) is a unique form of chronic daily headache (CDH) which is marked by a daily headache from onset, typically occurring in individuals without a significant prior history of headaches. There are two subforms of NDPH: one which is self-limited and normally goes away without therapy, and a more chronic refractory form which is unresponsive to typical headache treatment strategies. The pathogenesis of NDPH is unknown but recent observations suggest a connection with cervical spine hypermobility and elevation of proinflammatory cytokines in the cerebrospinal fluid (CSF). Recognized triggers for NDPH include infection, stressful life events, and surgical procedures. Clinically, NDPH is characterized by continuous head pain of mild to severe intensity. Migrainous symptoms are common. The syndrome appears to affect women in their teens and 20s, while males develop NDPH later in life in their 50s or 60s. There are no recognized treatments for this condition, although treatment options will be discussed. Secondary mimics of NDPH will also be touched upon in this chapter. Copyright © 2011 Elsevier B.V. All rights reserved.

  8. Grafting of styrene into pre-irradiated fluoropolymer films: Influence of base material and irradiation temperature

    NASA Astrophysics Data System (ADS)

    Lappan, Uwe; Geißler, Uwe; Gohs, Uwe; Uhlmann, Steffi

    2010-10-01

    In this study, the influence of irradiation temperature on mechanical properties of three fluoropolymers and on grafting of styrene into the polymers by the pre-irradiation method was investigated. Electron paramagnetic resonance spectroscopy and infrared spectroscopy were used to characterize the irradiated polymers regarding trapped radical species and changes in the chemical structure, respectively. For poly(tetrafluoroethylene-co-perfluoropropyl vinyl ether) (PFA) the irradiation temperature was found to be an important factor for tensile strength and elongation at break of the pre-irradiated film. No strong effect of irradiation temperature on the mechanical properties was noticed for poly(tetrafluoroethylene-co-ethylene) (ETFE); however the yield of grafting drops at high irradiation temperatures. Finally, mechanical properties of poly(tetrafluoroethylene) (PTFE) were found to be dramatically altered, even if the film was irradiated at elevated temperature.

  9. The Measurement of the Solar Spectral Irradiance Variability at 782 nm during the Solar Cycle 24 using the SES on-board PICARD

    NASA Astrophysics Data System (ADS)

    Meftah, Mustapha; Hauchecorne, Alain; Irbah, Abdanour; Bekki, Slimane

    2016-04-01

    A Sun Ecartometry Sensor (SES) was developed to provide the stringent pointing requirements of the PICARD satellite. The SES sensor produced an image of the Sun at 782+/-5 nm. From the SES data, we obtained a new time series of the solar spectral irradiance at 782nm from 2010 to 2014. SES observations provided a qualitatively consistent evolution of the solar spectral irradiance variability at 782 nm during the solar cycle 24. Comparisons will be made with Spectral And Total Irradiance REconstruction for the Satellite era (SATIRE-S) semi-empirical model and with the Spectral Irradiance Monitor instrument (SIM) on-board the Solar Radiation and Climate Experiment satellite (SORCE). These data will help to improve the representation of the solar forcing in the IPSL Global Circulation Model.

  10. Early Parental Abuse and Daily Assistance to Aging Parents With Disability: Associations With the Middle-Aged Adults' Daily Well-being.

    PubMed

    Liu, Yin; Kong, Jooyoung; Bangerter, Lauren R; Zarit, Steven H; Almeida, David M

    2018-01-09

    The current study examined the within-person association between providing daily assistance to aging parents with disability and adult children's daily mood in the context of early relationship with parents. We used data from 782 participants and 5,758 daily interviews from the Midlife in the United States (MIDUS) Refresher, with 248 people self-reported providing daily assistance ranging from 1 to 8 days out of the entire daily-interview period. Multilevel models were fit to examine the moderating effect of physical and emotional abuse from parents in early life on the associations between daily assistance to parents today and yesterday and daily mood. Additional analyses were conducted to examine whether the moderating effect of parental abuse remained when the assistance was provided for other family members and friends. Providing assistance today and yesterday to parents had immediate and lagged associations with higher negative affect when adult children experienced childhood emotional abuse from parents. No significant findings were found for daily positive affect. The moderating effect of parental abuse became nonsignificant when the assistance was provided to other family members or friends. Daily assistance to parents with disability needs to be examined in the context of the relationship history with parents. The impact of childhood abuse can linger long after the actual incident. Frequent early emotional abuse from parents was associated with greater distress when the middle-aged provided daily assistance to their aging parents. © The Author(s) 2018. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  11. Once-daily USL255 as adjunctive treatment of partial-onset seizures: Randomized phase III study

    PubMed Central

    Chung, Steve S; Fakhoury, Toufic A; Hogan, R Edward; Nagaraddi, Venkatesh N; Blatt, Ilan; Lawson, Balduin; Arnold, Stephan; Anders, Bob; Clark, Annie M; Laine, Dawn; Meadows, R Shawn; Halvorsen, Mark B

    2014-01-01

    Objective To evaluate the efficacy and safety of USL255, Qudexy™ XR (topiramate) extended-release capsules, as an adjunctive treatment for refractory partial-onset seizures (POS) in adults taking one to three concomitant antiepileptic drugs. Methods In this global phase III study (PREVAIL; NCT01142193), 249 adults with POS were randomized 1:1 to once-daily USL255 (200 mg/day) or placebo. The primary and key secondary efficacy endpoints were median percent reduction in weekly POS frequency and responder rate (proportion of patients with ≥50% reduction in seizure frequency). Seizure freedom was also assessed. Safety (adverse events, clinical and laboratory findings), as well as treatment effects on quality of life (QOLIE-31-P) and clinical global impression of change (CGI-C), were evaluated. Results Across the entire 11-week treatment phase, USL255 significantly reduced the median percent seizure frequency and significantly improved responder rate compared with placebo. Efficacy over placebo was observed early in treatment, in patients with highly refractory POS, and in those with the most debilitating seizure types (i.e., complex partial, partial secondarily generalized). USL255 was safe and generally well tolerated with a low incidence of neurocognitive adverse events. USL255 was associated with significant clinical improvement without adversely affecting quality of life. Significance The PREVAIL phase III clinical study demonstrated that once-daily USL255 (200 mg/day) significantly improved seizure control and was safe and generally well tolerated with few neurocognitive side effects. PMID:24902983

  12. Cyclic, low-dose total body irradiation for metastatic neuroblastoma

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    D'Angio, G.J.; Evans, A.E.

    1983-12-01

    Total body irradiation (TBI) can be thought of as a systemic anticancer agent. It therefore might best be given like an adjuvant drug, i.e., in tolerable doses, cyclically. The therapeutic ratio between normal bone marrow stem cells and suitably sensitive cancer cells should be widened by these means. Fourteen children with advanced (Stage IV) neuroblastomas were given 100-150 rad TBI in 50 rad daily fractions along with each three-week cycle of standard triple-agent chemotherapy (vincristine, DTIC, cyclophosphamide). Two patients died of toxicity and one is still undergoing therapy. Four of the remaining 12 survive free of disease for 12+ tomore » 31+ months. The regimen is well tolerated, but prolonged, pronounced bone marrow depression, especially thrombocytopenia, commonly occurs after doses of 300-450 rad.« less

  13. The polymyalgia rheumatica activity score in daily use: proposal for a definition of remission.

    PubMed

    Leeb, Burkhard F; Rintelen, Bernhard; Sautner, Judith; Fassl, Christian; Bird, Howard A

    2007-06-15

    To confirm the reliability and applicability of the Polymyalgia Rheumatica Disease Activity Score (PMR-AS), and to establish a threshold for remission. First, 78 patients with PMR (50 women/28 men, mean age 65.97 years) were enrolled in a cross-sectional evaluation. The PMR-AS, patient's satisfaction with disease status (PATSAT; range 1-5), erythrocyte sedimentation rate (ESR; first hour), and a visual analog scale of patients' general health assessment (VAS patient global; range 0-100) were recorded. Subsequently, another 39 PMR patients (24 women/15 men, mean age 68.12 years) were followed longitudinally. Relationships between the PMR-AS, PATSAT, ESR, and VAS patient global were analyzed by the Kruskal-Wallis test, Spearman's rank correlation, and kappa statistics. PMR-AS values in patients with a PATSAT score of 1 and a VAS patient global <10 formed the basis to establish a remission threshold. PMR-AS values were significantly related to PATSAT (P < 0.001), VAS patient global (P < 0.001), and ESR (P < 0.01). PATSAT and VAS patient global were reasonably different (kappa = 0.226). The median PMR-AS score in patients with PATSAT score 1 and VAS patient global <10 was 0.7 (range 0-3.3), and the respective 75th percentile was 1.3. To enhance applicability, a range from 0 to 1.5 was proposed to define remission in PMR. The median ESR in these patients was 10 mm/hour (range 3-28), indicating external validity. We demonstrated the reliability, validity, and applicability of the PMR-AS in daily routine. Moreover, we proposed a remission threshold (0-1.5) founded on patient-dependent parameters.

  14. Optical metabolic imaging of irradiated rat heart exposed to ischemia-reperfusion injury

    NASA Astrophysics Data System (ADS)

    la Cour, Mette Funding; Mehrvar, Shima; Heisner, James S.; Motlagh, Mohammad Masoudi; Medhora, Meetha; Ranji, Mahsa; Camara, Amadou K. S.

    2018-01-01

    Whole thoracic irradiation (WTI) is known to cause deterioration in cardiac function. Whether irradiation predisposes the heart to further ischemia and reperfusion (IR) injury is not well known. The aim of this study is to examine the susceptibility of rat hearts to IR injury following a single fraction of 15 Gy WTI and to investigate the role of mitochondrial metabolism in the differential susceptibility to IR injury. After day 35 of irradiation, ex vivo hearts from irradiated and nonirradiated rats (controls) were exposed to 25-min global ischemia followed by 60-min IR, or hearts were perfused without IR for the same protocol duration [time controls (TC)]. Online fluorometry of metabolic indices [redox state: reduced nicotinamide adenine dinucleotide (NADH), oxidized flavin adenine dinucleotide (FAD), and NADH/FAD redox ratio] and functional variables [systolic left ventricular pressure (LVP), diastolic LVP (diaLVP), coronary flow (CF), and heart rate were recorded in the beating heart; developed LVP (dLVP) and rate pressure product (RPP)] were derived. At the end of each experimental protocol, hearts were immediately snap frozen in liquid N2 for later three-dimensional imaging of the mitochondrial redox state using optical cryoimaging. Irradiation caused a delay in recovery of dLVP and RPP after IR when compared to nonirradiated hearts but recovered to the same level at the end of reperfusion. CF in the irradiated hearts recovered better than the control hearts after IR injury. Both fluorometry and 3-D cryoimaging showed that in WTI and control hearts, the redox ratio increased during ischemia (reduced) and decreased on reperfusion (oxidized) when compared to their respective TCs; however, there was no significant difference in the redox state between WTI and controls. In conclusion, our results show that although irradiation of rat hearts compromised baseline cardiovascular function, it did not alter cardiac mitochondrial redox state and induce greater

  15. Global Sensitivity Analysis and Parameter Calibration for an Ecosystem Carbon Model

    NASA Astrophysics Data System (ADS)

    Safta, C.; Ricciuto, D. M.; Sargsyan, K.; Najm, H. N.; Debusschere, B.; Thornton, P. E.

    2013-12-01

    We present uncertainty quantification results for a process-based ecosystem carbon model. The model employs 18 parameters and is driven by meteorological data corresponding to years 1992-2006 at the Harvard Forest site. Daily Net Ecosystem Exchange (NEE) observations were available to calibrate the model parameters and test the performance of the model. Posterior distributions show good predictive capabilities for the calibrated model. A global sensitivity analysis was first performed to determine the important model parameters based on their contribution to the variance of NEE. We then proceed to calibrate the model parameters in a Bayesian framework. The daily discrepancies between measured and predicted NEE values were modeled as independent and identically distributed Gaussians with prescribed daily variance according to the recorded instrument error. All model parameters were assumed to have uninformative priors with bounds set according to expert opinion. The global sensitivity results show that the rate of leaf fall (LEAFALL) is responsible for approximately 25% of the total variance in the average NEE for 1992-2005. A set of 4 other parameters, Nitrogen use efficiency (NUE), base rate for maintenance respiration (BR_MR), growth respiration fraction (RG_FRAC), and allocation to plant stem pool (ASTEM) contribute between 5% and 12% to the variance in average NEE, while the rest of the parameters have smaller contributions. The posterior distributions, sampled with a Markov Chain Monte Carlo algorithm, exhibit significant correlations between model parameters. However LEAFALL, the most important parameter for the average NEE, is not informed by the observational data, while less important parameters show significant updates between their prior and posterior densities. The Fisher information matrix values, indicating which parameters are most informed by the experimental observations, are examined to augment the comparison between the calibration and global

  16. Irradiation of meat products, chicken and use of irradiated spices for sausages

    NASA Astrophysics Data System (ADS)

    Kiss, I. F.; Beczner, J.; Zachariev, Gy.; Kovács, S.

    The shelf-life of packed minced meat has been increased at least threefold at 4°C by applying a 2 kGy dose. Results have been confirmed by detailed quatitative microbiological examinations. Sensory evaluations show no significant difference between the unirradiated samples. The optimal average dose was 4 kGy for packed-frosen chicken. The number of mesophilic aerobic microbes was reduced by 2, that of psychrotolerant by 2-3 and that of Enterbacteriaceae by 3-4 orders of magnitude by 4 kGy. S. aureus and Salmonella could not be detected in the irradiated samples. In sensory evaluations there was no significant difference between untreated and irradiated samples. In 1984-1985 5100 kg irradiated chickens were marketed labelled as radiation treated. Irradiated spices (5 kGy) were used in the production of sausages (heat-treated and non-heat-treated) under industrial conditions. The microbiological contamination of irradiated spices was lower than that of ethylene oxide treated ones. The cell count in products made with irradiated spices was lower than in those made with unirradiated spices. The sausages proved to be of very good quality. In accordance with the permission, products were marketed and because of the low ratio of spices there was no need to declare them as using irradiated spices.

  17. Modelling sub-daily evaporation from a small reservoir.

    NASA Astrophysics Data System (ADS)

    McGloin, Ryan; McGowan, Hamish; McJannet, David; Burn, Stewart

    2013-04-01

    Accurate quantification of evaporation from small water storages is essential for water management and is also required as input in some regional hydrological and meteorological models. Global estimates of the number of small storages or lakes (< 0.1 kilometers) are estimated to be in the order of 300 million (Downing et al., 2006). However, direct evaporation measurements at small reservoirs using the eddy covariance or scintillometry techniques have been limited due to their expensive and complex nature. To correctly represent the effect that small water bodies have on the regional hydrometeorology, reliable estimates of sub-daily evaporation are necessary. However, evaporation modelling studies at small reservoirs have so far been limited to quantifying daily estimates. In order to ascertain suitable methods for accurately modelling hourly evaporation from a small reservoir, this study compares evaporation results measured by the eddy covariance method at a small reservoir in southeast Queensland, Australia, to results from several modelling approaches using both over-water and land-based meteorological measurements. Accurate predictions of hourly evaporation were obtained by a simple theoretical mass transfer model requiring only over-water measurements of wind speed, humidity and water surface temperature. An evaporation model that was recently developed for use in small reservoir environments by Granger and Hedstrom (2011), appeared to overestimate the impact stability had on evaporation. While evaporation predictions made by the 1-dimensional hydrodynamics model, DYRESM (Dynamic Reservoir Simulation Model) (Imberger and Patterson, 1981), showed reasonable agreement with measured values. DYRESM did not show any substantial improvement in evaporation prediction when inflows and out flows were included and only a slighter better correlation was shown when over-water meteorological measurements were used in place of land-based measurements. Downing, J. A., Y. T

  18. Anti-inflammatory effect of 635 nm irradiations on in vitro direct/indirect irradiation model.

    PubMed

    Lim, WonBong; Choi, Hongran; Kim, Jisun; Kim, Sangwoo; Jeon, SangMi; Zheng, Hui; Kim, DoMan; Ko, Youngjong; Kim, Donghwi; Sohn, HongMoon; Kim, OkJoon

    2015-02-01

    Low-level laser therapy (LLLT) has been promoted for its beneficial effects on tissue healing and pain relief. As during laser treatment it is possible to irradiate only a small area of the surface body or wound and, correspondingly, of a very small volume of the circulating blood, it is necessary to explain how its photomodification can lead to a wide spectrum of therapeutic effects. To establish the experimental model for indirect irradiation, irradiation with 635 nm was performed on immortalized human gingival fibroblasts (IGFs) in the presence of Porphyromonas gingivalis lipopolysaccharides (LPS). The irradiated medium was transferred to non-irradiated IGFs which were compared with direct irradiated IGFs. The protein expressions were assessed by Western blot, and prostaglandin E2 (PGE2 ) was measured using an enzyme-linked immunoassay. Reactive oxygen species (ROS) were measured by DCF-DA; cytokine profiles were assessed using a human inflammation antibody array. Cyclooxygenase-2 (COX-2) protein expression and PGE2 production were significantly increased in the LPS-treated group and decreased in both direct and indirect irradiated IGFs. Unlike direct irradiated IGFs, ROS level in indirect irradiated IGFs was decreased by time-dependent manners. There were significant differences of released granulocyte colony-stimulating factor (G-CSF), regulated on activated normal T-cell expressed and secreted (RANTES), and I-TAC level observed compared with direct and indirect irradiated IGFs. In addition, in the indirect irradiation group, phosphorylations of C-Raf and Erk1/2 increased significantly compared with the direct irradiation group. Thus, we suggest that not only direct exposure with 635 nm light, but also indirect exposure with 635 nm light can inhibit activation of pro-inflammatory mediators and may be clinically useful as an anti-inflammatory tool. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  19. Attributing Historical Changes in Probabilities of Record-Breaking Daily Temperature and Precipitation Extreme Events

    DOE PAGES

    Shiogama, Hideo; Imada, Yukiko; Mori, Masato; ...

    2016-08-07

    Here, we describe two unprecedented large (100-member), longterm (61-year) ensembles based on MRI-AGCM3.2, which were driven by historical and non-warming climate forcing. These ensembles comprise the "Database for Policy Decision making for Future climate change (d4PDF)". We compare these ensembles to large ensembles based on another climate model, as well as to observed data, to investigate the influence of anthropogenic activities on historical changes in the numbers of record-breaking events, including: the annual coldest daily minimum temperature (TNn), the annual warmest daily maximum temperature (TXx) and the annual most intense daily precipitation event (Rx1day). These two climate model ensembles indicatemore » that human activity has already had statistically significant impacts on the number of record-breaking extreme events worldwide mainly in the Northern Hemisphere land. Specifically, human activities have altered the likelihood that a wider area globally would suffer record-breaking TNn, TXx and Rx1day events than that observed over the 2001- 2010 period by a factor of at least 0.6, 5.4 and 1.3, respectively. However, we also find that the estimated spatial patterns and amplitudes of anthropogenic impacts on the probabilities of record-breaking events are sensitive to the climate model and/or natural-world boundary conditions used in the attribution studies.« less

  20. Food irradiation in the United States: irradiation as a phytosanitary treatment for fresh fruits and vegetables and for the control of microorganisms in meat and poultry

    NASA Astrophysics Data System (ADS)

    Ross, Ralph T.; Engeljohn, Dan

    2000-03-01

    Recently there has been a renewed focus on food irradiation in the United States (US) for the disinfestation of fresh fruits and vegetables to eliminate pests from imported agricultural commodities that could threaten the economic viability of American agriculture and for the control of bacterium E. coli 0157:H7 in beef, a pathogen that threatens the safety of the US domestic food supply. In January 1999 USDA/APHIS published in the Federal Register a rule which authorized irradiation as a guarantee treatment for papayas for movement from Hawaii to the US mainland. This treatment was never used for a number of reasons. However, in December, 1993, the US Environmental Protection Agency (EPA) published its final rule to terminate production and consumption of methyl bromide, the only remaining broad spectrum fumigant for disinfesting agricultural commodities for pests of quarantine significance on imported and exported commodities. With increased global trade pressures and the possible loss of methyl bromide as a fumigant for regulatory pests treatment made it imperative that practical treatment options be explored including irradiation. In May 1996, USDA/APHIS published a Notice of Policy which sets forth a policy statement that share positions and policies of USDA concerning the use of irradiation as a phytosanitary treatment. Subsequently in July, 1997, USDA/APHIS amended its Hawaiian regulation by increasing the dose required for papayas intended for interstate movement and by allowing carambolas and litchis also to move interstate as well. Fruits from Hawaii to the US mainland are currently being irradiated and distributed in commerce throughout the US Irradiation treatments now afford movement of many exotic fruits to the US mainland that could not be done earlier due to the lack of available treatment methods. To help combat this potential public health problem, the US Food and Drug Administration (FDA) approved treating red meat products. This process has been

  1. Colorimetry provides a rapid objective measurement of de novo hair growth rate in mice.

    PubMed

    Tzung, Tien-Yi; Yang, Chia-Yi; Huang, Yung-Chang; Kao, Fu-Jen

    2009-11-01

    Depilated mice have been used as a test platform for hair growth-regulating agents. However, currently available assessment tools for hair growth in mice are less than ideal. Tristimulus colorimetry of the fur color of depilated agouti, albino, and black mice with L*, a*, and b* values were performed daily until the full growth of pelage. Using light-emitting diode (LED) irradiation (650 and 890 nm) with a daily dose of 3.5 J/cm(2) as hair growth regulators, the hair growth rates observed by the global assessment were compared with those derived from colorimetry. In contrast to a* and b* values, L* values changed more drastically over time in the anagen phase regardless of fur color. Unlike the inhibitory effect of 650 nm irradiation, LED of 890 nm promoted de novo hair regrowth in mice. The difference in hair growth rates detected by colorimetry paralleled the observation made by the global assessment. The L* value of fur color obtained by tristimulus colorimetry was a sensitive yet quantitative indicator of de novo hair growth, and could be used to project the hair growth rate in mice.

  2. Daily Living Resources

    MedlinePlus

    ... PPMD. Click here to review PPMD’s policy on corporate support . Daily Living Resources PPMD Resource Fair Participants ... About PPMD ❯ Mission & Impact Staff & Board News History Finance & Operations Partners Media Contact us Get Involved ❯ Donate ...

  3. Key results from irradiation and post-irradiation examination of AGR-1 UCO TRISO fuel

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Demkowicz, Paul A.; Hunn, John D.; Petti, David A.

    The AGR-1 irradiation experiment was performed as the first test of tristructural isotropic (TRISO) fuel in the US Advanced Gas Reactor Fuel Development and Qualification Program. The experiment consisted of 72 right cylinder fuel compacts containing approximately 3 × 105 coated fuel particles with uranium oxide/uranium carbide (UCO) fuel kernels. The fuel was irradiated in the Advanced Test Reactor for a total of 620 effective full power days. Fuel burnup ranged from 11.3 to 19.6% fissions per initial metal atom and time-average, volume-average irradiation temperatures of the individual compacts ranged from 955 to 1136 °C. This paper focuses on keymore » results from the irradiation and post-irradiation examination, which revealed a robust fuel with excellent performance characteristics under the conditions tested and have significantly improved the understanding of UCO coated particle fuel irradiation behavior. The fuel exhibited zero TRISO coating failures (failure of all three dense coating layers) during irradiation and post-irradiation safety testing at temperatures up to 1700 °C. Advanced PIE methods have allowed particles with SiC coating failure that were discovered to be present in a very-low population to be isolated and meticulously examined, which has elucidated the specific causes of SiC failure in these specimens. The level of fission product release from the fuel during irradiation and post-irradiation safety testing has been studied in detail. Results indicated very low release of krypton and cesium through intact SiC and modest release of europium and strontium, while also confirming the potential for significant silver release through the coatings depending on irradiation conditions. Focused study of fission products within the coating layers of irradiated particles down to nanometer length scales has provided new insights into fission product transport through the coating layers and the role various fission products may have on coating

  4. Key results from irradiation and post-irradiation examination of AGR-1 UCO TRISO fuel

    DOE PAGES

    Demkowicz, Paul A.; Hunn, John D.; Petti, David A.; ...

    2017-09-10

    The AGR-1 irradiation experiment was performed as the first test of tristructural isotropic (TRISO) fuel in the US Advanced Gas Reactor Fuel Development and Qualification Program. The experiment consisted of 72 right cylinder fuel compacts containing approximately 3 × 105 coated fuel particles with uranium oxide/uranium carbide (UCO) fuel kernels. The fuel was irradiated in the Advanced Test Reactor for a total of 620 effective full power days. Fuel burnup ranged from 11.3 to 19.6% fissions per initial metal atom and time-average, volume-average irradiation temperatures of the individual compacts ranged from 955 to 1136 °C. This paper focuses on keymore » results from the irradiation and post-irradiation examination, which revealed a robust fuel with excellent performance characteristics under the conditions tested and have significantly improved the understanding of UCO coated particle fuel irradiation behavior. The fuel exhibited zero TRISO coating failures (failure of all three dense coating layers) during irradiation and post-irradiation safety testing at temperatures up to 1700 °C. Advanced PIE methods have allowed particles with SiC coating failure that were discovered to be present in a very-low population to be isolated and meticulously examined, which has elucidated the specific causes of SiC failure in these specimens. The level of fission product release from the fuel during irradiation and post-irradiation safety testing has been studied in detail. Results indicated very low release of krypton and cesium through intact SiC and modest release of europium and strontium, while also confirming the potential for significant silver release through the coatings depending on irradiation conditions. Focused study of fission products within the coating layers of irradiated particles down to nanometer length scales has provided new insights into fission product transport through the coating layers and the role various fission products may have on coating

  5. Positioning accuracy and daily dose assessment for prostate cancer treatment using in-room CT image guidance at a proton therapy facility.

    PubMed

    Maeda, Yoshikazu; Sato, Yoshitaka; Minami, Hiroki; Yasukawa, Yutaka; Yamamoto, Kazutaka; Tamamura, Hiroyasu; Shibata, Satoshi; Bou, Sayuri; Sasaki, Makoto; Tameshige, Yuji; Kume, Kyo; Ooto, Hiroshi; Kasahara, Shigeru; Shimizu, Yasuhiro; Saga, Yusuke; Omoya, Akira; Saitou, Makoto

    2018-05-01

    To evaluate the effectiveness of CT image-guided proton radiotherapy for prostate cancer by analyzing the positioning uncertainty and assessing daily dose change due to anatomical variations. Patients with prostate cancer were treated by opposed lateral proton beams based on a passive scattering method using an in-room CT image-guided system. The system employs a single couch for both CT scanning and beam delivery. The patient was positioned by matching the boundary between the prostate and the rectum's anterior region identified in the CT images to the corresponding boundary in the simulator images after bone matching. We acquired orthogonal kV x-ray images after couch movement and confirmed the body position by referring to the bony structure prior to treatment. In offline analyses, we contoured the targeted anatomical structures on 375 sets of daily in-room CT images for 10 patients. The uncertainty of the image-matching procedure was evaluated using the prostate contours and actual couch corrections. We also performed dose calculations using the same set of CT images, and evaluated daily change of dose-volume histograms (DVHs) to compare the effectiveness of the treatment using prostate matching to the bone-matching procedure. The isocenter shifts by prostate matching after bone matching were 0.5 ± 1.8 and -0.8 ± 2.6 mm along the superior-inferior (SI) and anterior-posterior (AP) directions, respectively. The body movement errors (σ) after couch movement were 0.7, 0.5, and 0.3 mm along the lateral, SI and AP direction, respectively, for 30 patients. The estimated errors (σ) in the prostate matching were 1.0 and 1.3 mm, and, in conjunction with the movement errors, the total positioning uncertainty was estimated to be 1.0 and 1.4 mm along the SI and AP directions, respectively. Daily DVH analyses showed that in the prostate matching, 98.7% and 86.1% of the total 375 irradiations maintained a dose condition of V 95%  > 95% for the prostate and a

  6. Activities of daily living measured by the Harvard Automated Phone Task track with cognitive decline over time in non-demented elderly.

    PubMed

    Marshall, Gad A; Aghjayan, Sarah L; Dekhtyar, Maria; Locascio, Joseph J; Jethwani, Kamal; Amariglio, Rebecca E; Johnson, Keith A; Sperling, Reisa A; Rentz, Dorene M

    2017-01-01

    Impairment in activities of daily living is a major burden to both patients and caregivers. Mild impairment in instrumental activities of daily living is often seen at the stage of mild cognitive impairment. The field of Alzheimer's disease is moving toward earlier diagnosis and intervention and more sensitive and ecologically valid assessments of instrumental or complex activities of daily living are needed. The Harvard Automated Phone Task, a novel performance-based activities of daily living instrument, has the potential to fill this gap. To further validate the Harvard Automated Phone Task by assessing its longitudinal relationship to global cognition and specific cognitive domains in clinically normal elderly and individuals with mild cognitive impairment. In a longitudinal study, the Harvard Automated Phone Task was associated with cognitive measures using mixed effects models. The Harvard Automated Phone Task's ability to discriminate across diagnostic groups at baseline was also assessed. Academic clinical research center. Two hundred and seven participants (45 young normal, 141 clinically normal elderly, and 21 mild cognitive impairment) were recruited from the community and the memory disorders clinics at Brigham and Women's Hospital and Massachusetts General Hospital. Participants performed the three tasks of the Harvard Automated Phone Task, which consist of navigating an interactive voice response system to refill a prescription (APT-Script), select a new primary care physician (APT-PCP), and make a bank account transfer and payment (APT-Bank). The 3 tasks were scored based on time, errors, repetitions, and correct completion of the task. The primary outcome measure used for each of the tasks was total time adjusted for correct completion. The Harvard Automated Phone Task discriminated well between young normal, clinically normal elderly, and mild cognitive impairment participants (APT-Script: p<0.001; APT-PCP: p<0.001; APT-Bank: p=0.04). Worse

  7. The impact of irritable bowel syndrome on daily functioning: Characterizing and understanding daily consequences of IBS.

    PubMed

    Ballou, S; Keefer, L

    2017-04-01

    Despite the well-documented economic and psychosocial burden of irritable bowel syndrome (IBS), few studies have focused on the impact of IBS on daily activities. This study aims to quantitate impairment in daily activities among IBS patients and to evaluate the relationship between impairment, IBS, quality of life, and psychiatric symptoms. A total of 179 participants meeting ROME-III criteria for IBS completed an online research survey evaluating the following variables: (i) the impact of IBS on daily activities, (ii) comorbid psychiatric diagnoses, (iii) symptom severity, (iv) quality of life, and (v) symptom-specific cognitive affective factors related to IBS. This sample reported a high degree of impairment due to IBS, with 76% of the sample reporting some degree of IBS-related impairment in at least five different domains of daily life. Rates of impairment were significantly higher for participants who met criteria for anxiety, depression, and/or panic disorder. This study contributes to existing literature by demonstrating a high level of daily impairment among patients with IBS, particularly those who meet criteria for anxiety, depression, and panic disorder. These findings support the importance of integrated psychosocial and medical care for IBS patients, and highlight the utility of evaluation and intervention for behavioral avoidance/impairment especially among those who exhibit signs or symptoms of psychiatric diagnoses. © 2016 John Wiley & Sons Ltd.

  8. Craniospinal Irradiation for Trilateral Retinoblastoma Following Ocular Irradiation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Marks, Lawrence B.; Bentel, Gunilla; Sherouse, George W.

    A case study is presented. Craniospinal radiotherapy and a three-field pineal boost for trilateral retinoblastoma were delivered to a patient previously irradiated for ocular retinoblastoma. The availability of CT-based three-dimensional treatment planning provided the capability of identifying the previously irradiated volume as a three-dimensional anatomic structure and of designing a highly customized set of treatment beams that minimized reirradiation of that volume.

  9. Daily physical activity in stable heart failure patients.

    PubMed

    Dontje, Manon L; van der Wal, Martje H L; Stolk, Ronald P; Brügemann, Johan; Jaarsma, Tiny; Wijtvliet, Petra E P J; van der Schans, Cees P; de Greef, Mathieu H G

    2014-01-01

    Physical activity is the only nonpharmacological therapy that is proven to be effective in heart failure (HF) patients in reducing morbidity. To date, little is known about the levels of daily physical activity in HF patients and about related factors. The objectives of this study were to (a) describe performance-based daily physical activity in HF patients, (b) compare it with physical activity guidelines, and (c) identify related factors of daily physical activity. The daily physical activity of 68 HF patients was measured using an accelerometer (SenseWear) for 48 hours. Psychological characteristics (self-efficacy, motivation, and depression) were measured using questionnaires. To have an indication how to interpret daily physical activity levels of the study sample, time spent on moderate- to vigorous-intensity physical activities was compared with the 30-minute activity guideline. Steps per day was compared with the criteria for healthy adults, in the absence of HF-specific criteria. Linear regression analyses were used to identify related factors of daily physical activity. Forty-four percent were active for less than 30 min/d, whereas 56% were active for more than 30 min/d. Fifty percent took fewer than 5000 steps per day, 35% took 5000 to 10 000 steps per day, and 15% took more than 10 000 steps per day. Linear regression models showed that New York Heart Association classification and self-efficacy were the most important factors explaining variance in daily physical activity. The variance in daily physical activity in HF patients is considerable. Approximately half of the patients had a sedentary lifestyle. Higher New York Heart Association classification and lower self-efficacy are associated with less daily physical activity. These findings contribute to the understanding of daily physical activity behavior of HF patients and can help healthcare providers to promote daily physical activity in sedentary HF patients.

  10. Ion irradiation to simulate neutron irradiation in model graphites: Consequences for nuclear graphite

    NASA Astrophysics Data System (ADS)

    Galy, N.; Toulhoat, N.; Moncoffre, N.; Pipon, Y.; Bérerd, N.; Ammar, M. R.; Simon, P.; Deldicque, D.; Sainsot, P.

    2017-10-01

    Due to its excellent moderator and reflector qualities, graphite was used in CO2-cooled nuclear reactors such as UNGG (Uranium Naturel-Graphite-Gaz). Neutron irradiation of graphite resulted in the production of 14C which is a key issue radionuclide for the management of the irradiated graphite waste. In order to elucidate the impact of neutron irradiation on 14C behavior, we carried out a systematic investigation of irradiation and its synergistic effects with temperature in Highly Oriented Pyrolitic Graphite (HOPG) model graphite used to simulate the coke grains of nuclear graphite. We used 13C implantation in order to simulate 14C displaced from its original structural site through recoil. The collision of the impinging neutrons with the graphite matrix carbon atoms induces mainly ballistic damage. However, a part of the recoil carbon atom energy is also transferred to the graphite lattice through electronic excitation. The effects of the different irradiation regimes in synergy with temperature were simulated using ion irradiation by varying Sn(nuclear)/Se(electronic) stopping power. Thus, the samples were irradiated with different ions of different energies. The structure modifications were followed by High Resolution Transmission Electron Microscopy (HRTEM) and Raman microspectrometry. The results show that temperature generally counteracts the disordering effects of irradiation but the achieved reordering level strongly depends on the initial structural state of the graphite matrix. Thus, extrapolating to reactor conditions, for an initially highly disordered structure, irradiation at reactor temperatures (200 - 500 °C) should induce almost no change of the initial structure. On the contrary, when the structure is initially less disordered, there should be a "zoning" of the reordering: In "cold" high flux irradiated zones where the ballistic damage is important, the structure should be poorly reordered; In "hot" low flux irradiated zones where the ballistic

  11. Treatment of Hypertension: Favourable Effect of the Twice-Daily Compared to the Once-Daily (Evening) Administration of Perindopril and Losartan.

    PubMed

    Szauder, Ipoly; Csajági, Eszter; Major, Zsuzsanna; Pavlik, Gabor; Ujhelyi, Gabriella

    2015-01-01

    Little is known about the effect of twice daily administration of same dose of ACE inhibitor and ARB on the diurnal/nocturnal blood pressure (BP) ratio. We aimed to assess the effect of two widely used long-acting drugs: perindopril and losartan in the treatment of hypertension comparing the once-daily (evening) vs. twice-daily (morning and evening) administration with the same daily doses. Untreated primary hypertensive patients without complaints (a total of 164: 65 men, 99 women, 55.7 ± 13.7 years of age, 41-41 patients per treated groups) were selected with non-dipper phenomenon, estimated by diurnal index (DI) <10%. The effect of evening (8 mg perindopril or 100 mg losartan) vs morning and evening (4-4 mg perindopril or 50-50 mg losartan) administration was determined on a 14-day treatment by ABPM. The mean BP, the percent time elevation index, and the hyperbaric impact decreased in both drug groups. Significant difference was observed in the DI in the case of twice-daily administration vs once-daily evening dosing. The twice-daily administration with the same daily dose of perindopril or losartan seems to be more effective compared to the once daily evening administration in eliminating the non-dipper phenomenon. According to some authors the non-dipping phenomenon increases cardiovascular risk, while others are of the opinion that the association of non-dipping with cardiovascular events does not necessarily mean that selective treatment of non-dipping improves cardiovascular outcomes. © 2015 S. Karger AG, Basel.

  12. Definition of parameters of daily anisotropy of cosmic rays according to the world network of neutron monitors

    NASA Astrophysics Data System (ADS)

    Grigoryev, V. G.; Starodubtsev, S. A.; Potapova, V. D.

    2013-02-01

    In our previous works we have created the method of determination of parameters of cosmic ray daily anisotropy in the interplanetary environment based on the data provided by only single station - cosmic ray spectrograph named after A.I.Kuzmin. This method allows to predict the ingress of the Earth into large-scale solar wind disturbances with a probability of more than 70% and in advance time of about from several hours up to 2 days. Now it became possible to use the data of the neutron monitor networks, which can be seen in the neutron monitor database (NMDB) in real time. In this case the well-known method of global survey is applied for determination of cosmic ray anisotropy. Usage of the data of the cosmic ray station network allows to determine parameters of daily cosmic ray anisotropy with a greater accuracy.

  13. Never, non-daily, and daily smoking status and progression to daily cigarette smoking as correlates of major depressive episode in a national sample of youth: Results from the National Survey of Drug Use and Health 2013 to 2015.

    PubMed

    Cohn, Amy M

    2018-09-01

    Cigarette smoking is associated with depression, and new initiates who progress more quickly to daily smoking may be at enhanced risk. In a nationally representative sample of youth, this study examined the association between daily, non-daily, and never smoking with past-year and lifetime major depressive episode (MDE) and, among daily smokers, whether faster progression to daily smoking was associated with increased MDE risk. Data were from n = 44,921 youth aged 12-17 in the 2013-2015 National Survey on Drug Use and Health. Weighted adjusted multivariable logistic regression models were used to examine the association of smoking status (daily, non-daily, never) with lifetime and past-year MDE, and the association between progression from cigarette trial to daily smoking with MDE outcomes among daily smokers. Daily and non-daily smokers had similar rates of lifetime and past-year MDE; rates of MDE were approximately 50% lower among never smokers. Compared to never smokers, adjusted models showed that non-daily smokers had a higher risk of past-year and lifetime MDE, while daily smokers had a higher risk of past-year but not lifetime MDE. Daily smoking youth who progressed more quickly from cigarette trial to daily use had an increased risk of both lifetime and past-year MDE. Prevention programs should target factors associated with the shift from cigarette experimentation to regular use to curb deleterious consequences of use. Copyright © 2018. Published by Elsevier Ltd.

  14. Voluntary Running Prevents Progressive Memory Decline and Increases Adult Hippocampal Neurogenesis and Growth Factor Expression After Whole-Brain Irradiation

    PubMed Central

    Wong-Goodrich, Sarah J.E.; Pfau, Madeline L.; Flores, Catherine T.; Fraser, Jennifer A.; Williams, Christina L.; Jones, Lee W.

    2010-01-01

    Whole-brain irradiation (WBI) therapy produces progressive learning and memory deficits in patients with primary or secondary brain tumors. Exercise enhances memory and adult hippocampal neurogenesis in the intact brain, so we hypothesized that exercise may be an effective treatment to alleviate consequences of WBI. Previous studies using animal models to address this issue have yielded mixed results and have not examined potential molecular mechanisms. We investigated the short- and long-term effects of WBI on spatial learning and memory retention, and determined whether voluntary running after WBI aids recovery of brain and cognitive function. Forty adult female C57Bl/6 mice given a single dose of 5 Gy or sham WBI were trained 2.5 weeks and up to four months after WBI in a Barnes maze. Half of the mice received daily voluntary wheel access starting one month after sham- or WBI. Daily running following WBI prevented the marked decline in spatial memory retention observed months after irradiation. Bromodeoxyuridine (BrdU) immunolabeling and ELISA indicated that this behavioral rescue was accompanied by a partial restoration of newborn BrdU+/NeuN+ neurons in the dentate gyrus and increased hippocampal expression of brain-derived vascular endothelial growth factor and insulin-like growth factor, and occurred despite irradiation-induced elevations in hippocampal pro-inflammatory cytokines. WBI in adult mice produced a progressive memory decline consistent with what has been reported in cancer patients receiving WBI therapy. Our findings show that running can abrogate this memory decline and aid recovery of adult hippocampal plasticity, thus highlighting exercise as a potential therapeutic intervention. PMID:20884629

  15. Global risk of deadly heat

    NASA Astrophysics Data System (ADS)

    Mora, Camilo; Dousset, Bénédicte; Caldwell, Iain R.; Powell, Farrah E.; Geronimo, Rollan C.; Bielecki, Coral R.; Counsell, Chelsie W. W.; Dietrich, Bonnie S.; Johnston, Emily T.; Louis, Leo V.; Lucas, Matthew P.; McKenzie, Marie M.; Shea, Alessandra G.; Tseng, Han; Giambelluca, Thomas W.; Leon, Lisa R.; Hawkins, Ed; Trauernicht, Clay

    2017-07-01

    Climate change can increase the risk of conditions that exceed human thermoregulatory capacity. Although numerous studies report increased mortality associated with extreme heat events, quantifying the global risk of heat-related mortality remains challenging due to a lack of comparable data on heat-related deaths. Here we conducted a global analysis of documented lethal heat events to identify the climatic conditions associated with human death and then quantified the current and projected occurrence of such deadly climatic conditions worldwide. We reviewed papers published between 1980 and 2014, and found 783 cases of excess human mortality associated with heat from 164 cities in 36 countries. Based on the climatic conditions of those lethal heat events, we identified a global threshold beyond which daily mean surface air temperature and relative humidity become deadly. Around 30% of the world's population is currently exposed to climatic conditions exceeding this deadly threshold for at least 20 days a year. By 2100, this percentage is projected to increase to ~48% under a scenario with drastic reductions of greenhouse gas emissions and ~74% under a scenario of growing emissions. An increasing threat to human life from excess heat now seems almost inevitable, but will be greatly aggravated if greenhouse gases are not considerably reduced.

  16. Pharmacokinetic study of once–daily versus twice-daily abacavir and lamivudine in HIV type-1-infected children aged 3–<36 months

    PubMed Central

    2013-01-01

    Background Once-daily dosing of abacavir and lamivudine has been approved for adults, but paediatric data are insufficient. We conducted a pharmacokinetic study of once-daily and twice-daily abacavir and lamivudine in children aged 3–<36 months. Methods Children with stable HIV type-1 (HIV-1) RNA levels after 12 weeks treatment with twice-daily abacavir (8 mg/kg) with or without lamivudine (4 mg/kg) underwent plasma pharmacokinetic sampling. Children then switched to once-daily abacavir (16 mg/kg) with or without lamivudine (8 mg/kg), and sampling was repeated 4 weeks later. The area under the plasma concentration–time curve over 24 h (AUC0–24) and the maximum concentration (Cmax) were compared using geometric mean ratios (GMRs); 90% confidence intervals (CIs) within the range of 0.80–1.25 were considered bioequivalent. Results A total of 18 children (4, 6 and 8 in the 3–<12, 12–<24 and 24–<36 month age ranges, respectively) provided pharmacokinetic data for abacavir (17 for lamivudine). The GMR of AUC0–24, once-daily versus twice-daily, was 1.07 (90% CI 0.92–1.23) for abacavir and 0.91 (90% CI 0.79–1.06) for lamivudine. Cmax almost doubled on once-daily versus twice-daily dosing: abacavir and lamivudine GMRs were 2.04 (90% CI 1.73–2.42) and 1.78 (90% CI 1.52–2.09), respectively. At baseline, 12, 24 and 48 weeks, 89%, 94%, 100% and 89% of children had HIV-1 RNA<400 copies/ml, respectively. Conclusions Bioequivalence was demonstrated on AUC0–24 between twice-daily and once-daily abacavir; very similar AUC0–24 values were seen for twice-daily and once-daily lamivudine. Given that viral load suppression rates were maintained, these data suggest that once-daily abacavir and lamivudine might be an option for children aged 3–<36 months. PMID:20516550

  17. Efficacy and tolerability of rasagiline in daily clinical use--a post-marketing observational study in patients with Parkinson's disease.

    PubMed

    Reichmann, H; Jost, W H

    2010-09-01

    The MAO-B inhibitor rasagiline is indicated for the treatment of idiopathic Parkinson's disease (PD), and its use is supported by evidence from large-scale, controlled clinical studies. The post-marketing observational study presented here investigated the efficacy and tolerability of rasagiline treatment (monotherapy or combination therapy) in daily clinical practice. The study included patients with idiopathic PD who received rasagiline (recommended dose 1 mg, once daily) as monotherapy or combination therapy. The treatment and observation period was approximately 4 months. Outcome measures included the change from baseline in the Columbia University Rating Scale (CURS), the Unified PD Rating Scale fluctuation subscale, daily OFF time (patient home diaries) and the PD Questionnaire-39. Adverse drug reactions/adverse events (ADRs/AEs) and the physician's global judgement of tolerability and efficacy were also examined. Overall, 754 patients received rasagiline during the study. Patients treated with rasagiline (monotherapy or combination therapy) showed significant improvements from baseline in symptom severity (including classical motor and non-classical motor/non-motor symptoms) and quality of life (QoL). Patients receiving combination therapy also experienced significant reductions in daily OFF time. Tolerability was rated as good/very good in over 90% of patients. In daily clinical practice, monotherapy or combination therapy with rasagiline is able to improve PD symptoms, reduce OFF time, and improve QoL, whilst demonstrating favourable tolerability. In addition, rasagiline has a simple dosing schedule of one tablet, once daily, with no titration. These results are consistent with the pivotal rasagiline clinical studies (TEMPO, LARGO and PRESTO).

  18. Daily light integral and day light quality: Potentials and pitfalls of nighttime UV treatments on cucumber powdery mildew.

    PubMed

    Suthaparan, Aruppillai; Solhaug, Knut Asbjørn; Stensvand, Arne; Gislerød, Hans Ragnar

    2017-10-01

    Nighttime ultraviolet (UV) radiation, if applied properly, has a significant potential for management of powdery mildews in many crop species. In this study, the role of growth light duration, irradiance, a combination of both (daily light integral) and light spectral quality (blue or red) on the efficacy of UV treatments against powdery mildew caused by Podosphaera xanthii and the growth performance of cucumber plants was studied in growth chambers. Increasing daily light integral provided by high-pressure sodium lamps (HPS) decreased efficacy of nighttime UV treatments against P. xanthii, but it increased plant growth. Furthermore, the efficacy of nighttime UV decreased when day length was increased from 16 to 20h at a constant daily light integral. The efficacy of nighttime UV increased if red light was applied after UV treatment, showing the possibility of day length extension without reducing the effect of UV. Increasing the dose of blue light during daytime reduced the efficacy of nighttime UV in controlling the disease, whereas blue deficient growth light (<6% of blue) caused UV mediated curling of young leaves. Furthermore, application of blue light after nighttime UV reduced its disease control efficacy. This showed the importance of maintaining a minimum of blue light in the growth light before nighttime UV treatment. Findings from this study showed that optimization of nighttime UV for management of powdery mildew is dependent on the spectral composition of the photosynthetically active radiation. Copyright © 2017 Elsevier B.V. All rights reserved.

  19. Epidemiology of chronic daily headache.

    PubMed

    Pascual, J; Colás, R; Castillo, J

    2001-12-01

    Daily or near-daily headache is a widespread problem in clinical practice. The general term of chronic daily headache (CDH) encompasses those primary headaches presenting more than 15 days per month and lasting more than 4 hours per day. CDH includes transformed migraine (TM), chronic tension-type headache (CTTH), new daily persistent headache (NDPH), and hemicrania continua (HC). Around 40% of patients attending a specialized headache clinic meet CDH diagnostic criteria, of which 80% are women. In these clinics about 60% of patients suffer from TM, 20% from CTTH, and 20% meet NDPH criteria. Most, some 80%, overuse symptomatic medications. One should be very cautious on extrapolating these numbers to the general population. CDH prevalence in the general population seems to be around 4% to 5% (up to 8% to 9% for women). Regarding the prevalence of CDH subtypes, NDPH is rare (0.1%), whereas the prevalence of TM (1.5% to 2%) and CTTH (2.5% to 3%) is clearly higher. In contrast to data from specialized clinics, only around a quarter of CDH subjects in the general population overuse analgesics; the prevalence of CDH subjects with analgesic overuse being 1.1% to 1.9% of the general population. Most of these patients with analgesic overuse are TM patients.

  20. Hyperfractionated or Accelerated Hyperfractionated Re-irradiation with ≥42 Gy in Combination with Paclitaxel for Secondary/Recurrent Head-and-Neck Cancer.

    PubMed

    Rades, Dirk; Bartscht, Tobias; Idel, Christian; Schild, Steven E; Hakim, Samer G

    2018-06-01

    Patients with secondary/ recurrent squamous cell head and neck cancer (SCCHN) have poor prognoses. Outcomes of re-irradiation with ≥42 Gy plus paclitaxel for secondary/recurrent SCCHN are herein presented. Two patients re-irradiated for secondary/recurrent SCCHN were evaluated. Patients received 44.4 Gy (2×1.2 Gy/day) or 42.0 Gy (2×1.5 Gy/day), respectively, plus concurrent paclitaxel (35 mg/m 2 weekly or 20 mg/m 2 twice per week). One patient developed a locoregional recurrence and additional metastases at 12 months after re-irradiation and died at 13 months. The other patient developed multiple bone metastases at 103 months and died at 104 months. Acute toxicities included grade 2 anemia and mucositis in both patients. Radiation dermatitis was grade 2 in one patient and grade 3 in the other. Re-irradiation with 42.0-44.4 Gy given twice daily plus paclitaxel was well tolerated and achieved a favorable response. The results need to be confirmed in a prospective trial. Copyright© 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.