Science.gov

Sample records for government regulation

  1. Government Regulation of Higher Education.

    ERIC Educational Resources Information Center

    Hobbs, Walter C., Ed.

    Only lately has government regulation developed with great force among colleges and universities. A collection of essays examines that development from the perspectives of the legal scholar, the university president, the university lawyer, the government lawyer, the university's affirmative action officer, the professional association's government…

  2. Effects of Government Regulations on Higher Education.

    ERIC Educational Resources Information Center

    Bernhard, John T.; Hannah, Robert W.

    Results of a self-study conducted by Western Michigan University on the effects of government regulations on higher education are presented. The self-study, conducted with the aid of questionnaires, followup visits, or telephone calls, addressed the following main concerns: (1) academic programs; (2) maintenance, buildings, physical plant, and…

  3. International Religion Indexes: Government Regulation, Government Favoritism, and Social Regulation of Religion*

    PubMed Central

    Grim, Brian J.; Finke, Roger

    2014-01-01

    The study of religion is severely handicapped by a lack of adequate cross-national data. Despite the prominence of religion in international events and recent theoretical models pointing to the consequences of regulating religion, cross-national research on religion has been lacking. We strive to fill this void by developing measurement models and indexes for government regulation, government favoritism, and social regulation of religion. The indexes rely on data from an extensive coding of the 2003 International Religious Freedom Report for 196 countries and territories. Using a series of tests to evaluate the new data and indexes, we find that the measures developed are highly reliable and valid. The three indexes will allow researchers and others to measure the government’s subsidy and regulation of religion as well as the restrictions placed on religion by social and cultural forces beyond the state. PMID:25484633

  4. 75 FR 79455 - OPEN GOVERNMENT AND EVIDENCE-BASED REGULATION

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-20

    ... From the Federal Register Online via the Government Publishing Office ] OPEN GOVERNMENT AND EVIDENCE-BASED REGULATION There is a close connection, even an inextricable relationship, between open government and evidence- based regulation. If regulatory choices are based on careful analysis of the evidence, and if opportunities are provided...

  5. 75 FR 17410 - Federal Acquisition Regulation; Information Collection; Government Property

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-06

    ... Regulation; Information Collection; Government Property AGENCY: Department of Defense (DOD), General Services... approved information collection requirement concerning Government Property. Public comments are.... Purpose Property, as used in Part 45, means all property, both real and personal. It includes...

  6. 78 FR 26518 - Federal Acquisition Regulation; Government Property

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-07

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF DEFENSE GENERAL SERVICES ADMINISTRATION NATIONAL AERONAUTICS AND SPACE ADMINISTRATION 48 CFR Part 52 Federal Acquisition Regulation; Government Property CFR Correction In Title 48 of the Code of Federal...

  7. 7 CFR 999.300 - Regulation governing importation of raisins.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 8 2012-01-01 2012-01-01 false Regulation governing importation of raisins. 999.300... SPECIALTY CROPS; IMPORT REGULATIONS § 999.300 Regulation governing importation of raisins. (a) Definitions. For purposes of this section: (1) Raisins means grapes from which a part of the natural moisture...

  8. 7 CFR 999.300 - Regulation governing importation of raisins.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 8 2014-01-01 2014-01-01 false Regulation governing importation of raisins. 999.300... SPECIALTY CROPS; IMPORT REGULATIONS § 999.300 Regulation governing importation of raisins. (a) Definitions. For purposes of this section: (1) Raisins means grapes from which a part of the natural moisture...

  9. 7 CFR 999.300 - Regulation governing importation of raisins.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 8 2013-01-01 2013-01-01 false Regulation governing importation of raisins. 999.300... SPECIALTY CROPS; IMPORT REGULATIONS § 999.300 Regulation governing importation of raisins. (a) Definitions. For purposes of this section: (1) Raisins means grapes from which a part of the natural moisture...

  10. 76 FR 9527 - Regulations Governing Fees for Services

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-18

    ... Surface Transportation Board 49 CFR Part 1002 Regulations Governing Fees for Services AGENCY: Surface... regulations governing user fees for ] services. The proposed amendment would set the fee for certain formal... fees in accordance with the Independent Offices Appropriation Act of 1952 (IOAA). The IOAA...

  11. 77 FR 75362 - Government in the Sunshine Act Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-20

    ... From the Federal Register Online via the Government Publishing Office EQUAL EMPLOYMENT OPPORTUNITY COMMISSION 29 CFR Part 1612 Government in the Sunshine Act Regulations CFR Correction 0 In Title 29 of the Code of Federal Regulations, Parts 900 to 1899, revised as of July 1, 2012, on page 266, in Sec....

  12. Government and Education: The University as a Regulated Industry.

    ERIC Educational Resources Information Center

    Gellhorn, Ernest; Boyer, Barry B.

    1977-01-01

    Issues in institutional autonomy and government regulation are addressed: discretion of university administrators to exert control; openness, confidentiality, and controls over information; and regulations, reports, and government sanctions. Available from William S. Hein and Co., 1285 Main St., Buffalo, NY 14209. (MSE)

  13. 76 FR 39788 - Regulations Governing Fees for Services

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-07

    ... Surface Transportation Board 49 CFR Part 1002 Regulations Governing Fees for Services AGENCY: Surface Transportation Board. ACTION: Final rule. SUMMARY: The Board is amending the regulations governing user fees for services performed. The amendment sets the fee for certain formal complaints at $350. DATES: Effective...

  14. Bureaucrats and Brainpower: Government Regulation of Universities.

    ERIC Educational Resources Information Center

    Seabury, Paul, Ed.

    The exploration of the growth and cost benefit effectiveness of governmental regulation of higher education is examined in this book. An introductory article by Robert Hatfield examines university regulation from a businessman's perspective. Hatfield concludes that business and higher education must work together to curb the stream of regulation.…

  15. Broadcasting and Government; Responsibilities and Regulations.

    ERIC Educational Resources Information Center

    Emery, Walter B.

    The role of governmental agencies in the control of wire and radio communication, especially broadcasting, is explained. A major portion of the book concerns the broadcast spectrum, its character and utility for communications, and the technical rules which govern the allocation of radio frequencies and their use by various classes of stations,…

  16. 7 CFR 999.300 - Regulation governing importation of raisins.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 8 2011-01-01 2011-01-01 false Regulation governing importation of raisins. 999.300 Section 999.300 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE SPECIALTY CROPS; IMPORT REGULATIONS §...

  17. 76 FR 18072 - Federal Acquisition Regulation; Government Property Disposal; Forms

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-01

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF DEFENSE GENERAL SERVICES ADMINISTRATION NATIONAL AERONAUTICS AND SPACE ADMINISTRATION 48 CFR Part 53 Federal Acquisition Regulation; Government Property Disposal; Forms CFR Correction In Title 48 of the Code of...

  18. Congress, Laws, and Regulations: Government Documents. Academic Library Guide. Government Documents Series Number 2.

    ERIC Educational Resources Information Center

    Amen, Kathleen L.

    This document is the second in a series of four guides to the government documents collection in the academic library at St. Mary's University (San Antonio, Texas); the library has been a selective depository for U.S. Government publications since 1964. Focusing on congressional publications pertaining to laws and regulations, this guide describes…

  19. 43 CFR 8341.1 - Regulations governing use.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Regulations governing use. 8341.1 Section 8341.1 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR RECREATION PROGRAMS OFF-ROAD VEHICLES Conditions of Use §...

  20. 43 CFR 8341.1 - Regulations governing use.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Regulations governing use. 8341.1 Section 8341.1 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR RECREATION PROGRAMS OFF-ROAD VEHICLES Conditions of Use §...

  1. SIGNALS AND REGULATORS THAT GOVERN STREPTOMYCES DEVELOPMENT

    PubMed Central

    McCormick, Joseph R.; Flärdh, Klas

    2012-01-01

    Streptomyces coelicolor is the genetically best characterized species of a populous genus belonging to the Gram-positive Actinobacteria. Streptomycetes are filamentous soil organisms, well known for the production of a plethora of biologically active secondary metabolic compounds. The Streptomyces developmental life cycle is uniquely complex, and involves coordinated multicellular development with both physiological and morphological differentiation of several cell types, culminating in production of secondary metabolites and dispersal of mature spores. This review presents a current appreciation of the signaling mechanisms used to orchestrate the decision to undergo morphological differentiation, and the regulators and regulatory networks that direct the intriguing development of multigenomic hyphae, first to form specialized aerial hyphae, and then to convert them into chains of dormant spores. This current view of S. coelicolor development is destined for rapid evolution as data from “-omics” studies shed light on gene regulatory networks, new genetic screens identify hitherto unknown players, and the resolution of our insights into the underlying cell biological processes steadily improve. PMID:22092088

  2. 31 CFR 380.0 - What do these regulations govern?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... regulations at 31 CFR part 202 (Depositaries and Financial Agents of the Government), 31 CFR part 203 (Payment of Federal Taxes and the Treasury Tax and Loan Program), and 31 CFR part 225 (Acceptance of Bonds... to the acceptability and valuation of collateral that may be pledged under these programs. 31...

  3. 49 CFR Appendix E to Part 99 - Statutes Regulating Post-Employment Responsibilities of Government and Special Government Employees

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 1 2014-10-01 2014-10-01 false Statutes Regulating Post-Employment... Part 99—Statutes Regulating Post-Employment Responsibilities of Government and Special Government Employees Note: This appendix applies only to employees who terminated government service before January...

  4. 49 CFR Appendix E to Part 99 - Statutes Regulating Post-Employment Responsibilities of Government and Special Government Employees

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 1 2011-10-01 2011-10-01 false Statutes Regulating Post-Employment... Part 99—Statutes Regulating Post-Employment Responsibilities of Government and Special Government Employees Note: This appendix applies only to employees who terminated government service before January...

  5. 49 CFR Appendix E to Part 99 - Statutes Regulating Post-Employment Responsibilities of Government and Special Government Employees

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 1 2012-10-01 2012-10-01 false Statutes Regulating Post-Employment... Part 99—Statutes Regulating Post-Employment Responsibilities of Government and Special Government Employees Note: This appendix applies only to employees who terminated government service before January...

  6. 49 CFR Appendix E to Part 99 - Statutes Regulating Post-Employment Responsibilities of Government and Special Government Employees

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 1 2013-10-01 2013-10-01 false Statutes Regulating Post-Employment... Part 99—Statutes Regulating Post-Employment Responsibilities of Government and Special Government Employees Note: This appendix applies only to employees who terminated government service before January...

  7. Should states and local governments regulate dietary supplements?

    PubMed

    Starr, Ranjani

    2016-03-01

    Federal regulation of dietary supplements in the United States is governed by the Dietary Supplement Health and Education Act of 1994. The law has been criticized as weak and ineffective. Alarming research has emerged demonstrating that supplements may be mislabelled, contaminated, adulterated with dangerous or unknown compounds, or sold at toxic doses. As a result, the health community has raised concerns about the safety and quality of dietary supplements. Increased federal oversight is an important avenue for improving supplement safety; however, states and local governments may also pursue strategies to strengthen the overall regulatory control of dietary supplements. States and local governments have substantial experience in regulating other products that pose a risk to public health, such as tobacco. Additionally, much has been learned about the tactics the tobacco industry has employed to protect its interests. Lessons learned may be applied to new regulatory efforts aimed at improving the safety of dietary supplements at the state and local levels. Copyright © 2015 John Wiley & Sons, Ltd. PMID:26594006

  8. Understanding Philip Morris's pursuit of US government regulation of tobacco

    PubMed Central

    McDaniel, P; Malone, R

    2005-01-01

    Objective: To investigate Philip Morris's support of US Food and Drug Administration (FDA) regulation of tobacco products and analyse its relationship to the company's image enhancement strategies. Data sources: Internal Philip Morris documents released as part of the Master Settlement Agreement. Methods: Searches of the Legacy Tobacco Documents Library (http://legacy.library.ucsf.edu) beginning with such terms as "FDA" and "regulatory strategy" and expanding to include relevant new terms. Results: Philip Morris's support for government regulation of tobacco is part of a broader effort to address its negative public image, which has a damaging impact on the company's stock price, political influence, and employee morale. Through regulation, the company seeks to enhance its legitimacy, redefine itself as socially responsible, and alter the litigation environment. Whereas health advocates frame tobacco use as a public health policy issue, Philip Morris's regulatory efforts focus on framing tobacco use as an individual choice by informed adults to use a risky product. This framing allows Philip Morris to portray itself as a reasonable and responsible manufacturer and marketer of risky products. Conclusions: Philip Morris's ability to improve its image through support of FDA regulation may undermine tobacco control efforts aimed at delegitimising the tobacco industry. It may also create the impression that Philip Morris's products are being made safer and ultimately protect the company from litigation. While strong regulation of tobacco products and promotion remain critical public health goals, previous experiences with tobacco regulation show that caution may be warranted. PMID:15923470

  9. Government regulation to promote healthy food environments--a view from inside state governments.

    PubMed

    Shill, J; Mavoa, H; Allender, S; Lawrence, M; Sacks, G; Peeters, A; Crammond, B; Swinburn, B

    2012-02-01

    Food policy interventions are an important component of obesity-prevention strategies and can potentially drive positive changes in obesogenic environments. This study sought to identify regulatory interventions targeting the food environment, and barriers/facilitators to their implementation at the Australian state government level. In-depth interviews were conducted with senior representatives from state/territory governments, statutory authorities and non-government organizations (n =45) to examine participants' (i) suggestions for regulatory interventions for healthier food environments and (ii) support for pre-selected regulatory interventions derived from a literature review. Data were analysed using thematic and constant comparative analyses. Interventions commonly suggested by participants were regulating unhealthy food marketing; limiting the density of fast food outlets; pricing reforms to decrease fruit/vegetable prices and increase unhealthy food prices; and improved food labelling. The most commonly supported pre-selected interventions were related to food marketing and service. Primary production and retail sector interventions were least supported. The dominant themes were the need for whole-of-government and collaborative approaches; the influence of the food industry; conflicting policies/agenda; regulatory challenges; the need for evidence of effectiveness; and economic disincentives. While interventions such as public sector healthy food service policies were supported by participants, marketing restrictions and fiscal interventions face substantial barriers including a push for deregulation and private sector opposition. PMID:21955783

  10. Effect of Government Regulation on the Evolution of Sports Nutrition

    NASA Astrophysics Data System (ADS)

    Collins, Rick; Kalman, Douglas

    The sports nutrition segment of the dietary supplement industry enjoyed nearly a decade of unfettered growth under federal legislation passed in 1994. A series of breakthroughs in the dietary supplement field led to the development and marketing of innovative products designed to enhance performance, build muscle, or lose excess fat. As the popularity of these products soared and evolved into a multi-billion dollar industry, the sports nutrition supplement market drew the attention of federal and state regulatory bodies and sports antidoping authorities. Growing concerns over potential health risks and unfair athletic advantages have spurred government regulators and legislators to heighten the scrutiny of this market, leading to recent legislative amendments and increased government enforcement action.

  11. Impact of government regulation on health care technology

    NASA Astrophysics Data System (ADS)

    Berkowitz, Robert D.

    1994-12-01

    Increased government regulation of the medical device industry produces higher expenses, a longer time to return investment capital, and greater uncertainty. As a result there are fewer new ventures and reduced efforts to develop new technology in established companies. The current federal regulatory framework has shifted from monitoring the product to monitoring the process. The inability to reach perfect performance in such a regulated environment subject to continuous and fluid interpretation guarantees non-compliance and growing ethical tension. Without new medical technology, we may be unable to maintain quality medical coverage in the face of rising demand. The author proposes risk assessment to set regulatory priorities; the conversion of a national weapons lab to a national device testing lab; the establishment of device standards and the monitoring of in-use performance against these standards; and the education of patients and users as to the results of these examinations.

  12. Controversy over genetically modified organisms: the governing laws and regulations.

    PubMed

    Keatley, K L

    2000-01-01

    Genetically Modified Organisms (GMOs) are increasingly becoming a topic of controversy in the U.S. and abroad. The public is questioning their safety and wanting the products labeled as genetically modified. There are other concerns from some of the scientific world and some government officials and organizations such as the Food & Agricultural Organization (FAO) that question whether adequate research has been done to qualify GMOs as safe for long-term use. Of particular concern are the allergenic properties, a GMO may impart, possible transfer effects of antibiotic resistance (given that antibiotic resistant marker genes are used for many GMOs), the expression of previously unexpressed traits, and the drift of pollen from genetically modified crops. It has also been noted that the laws and regulations governing the biotechnology world are outdated, are not comprehensive, and span too many agencies. The primary agencies currently regulating biotechnology are the U.S. Department of Agriculture (USDA), the Food and Drug Administration (FDA), and the Environmental Protection Agency (EPA). PMID:11710306

  13. Pharmaceuticals in Australia: developments in regulation and governance.

    PubMed

    Lofgren, Hans; Boer, Rebecca de

    2004-06-01

    The pharmaceutical domain represents a type of internationalised policy network theorised in recent writings on neo-liberalism, neo-corporatism and governance. This article presents an analysis of developments in prescription drug regulation in Australia. A relatively stable, state-managed pattern of interaction has been superseded by less closed exchange, and the government itself has fragmented into agencies pursuing different objectives. Developments in the three core regulatory areas are described: safety and efficacy controls, social policy (access and equity), and state support for industry (economic) development. Consensus-building occurs within the context of the National Medicines Policy. The pharmaceutical industry, represented by Medicines Australia, has a stake in all aspects of pharmaceutical policy and regulation, and draws upon unique resources (expertise and lobbying capacity). The context for the developments described is Australia's abandonment of a protectionist version of the Keynesian welfare national state in favour of the model of the competition state, which is oriented towards support for the growth of high technology industries such as pharmaceuticals, premised on partnerships with business. PMID:15081192

  14. Governing inside the organization: interpreting regulation and compliance.

    PubMed

    Gray, Garry C; Silbey, Susan S

    2014-07-01

    Looking inside organizations at the different positions, expertise, and autonomy of the actors, the authors use multisite ethnographic data on safety practices to develop a typology of how the regulator, as the focal actor in the regulatory process, is interpreted within organizations. The findings show that organizational actors express constructions of the regulator as an ally, threat, and obstacle that vary with organizational expertise, authority, and continuity of relationship between the organizational member and the regulator. The article makes three contributions to the current understandings of organizational governance and regulatory compliance, thereby extending both institutional and ecological accounts of organizations' behavior with respect to their environments. First, the authors document not only variation across organizations but variable compliance within an organization. Second, the variations described do not derive from alternative institutional logics, but from variations in positions, autonomy, and expertise within each organization. From their grounded theory, the authors hypothesize that these constructions carry differential normative interpretations of regulation and probabilities for compliance, and thus the third contribution, the typology, when correlated with organizational hierarchy provides the link between microlevel action and discourse and organizational performance. PMID:25705781

  15. 7 CFR 999.1 - Regulation governing the importation of dates.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 8 2013-01-01 2013-01-01 false Regulation governing the importation of dates. 999.1 Section 999.1 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING... CROPS; IMPORT REGULATIONS § 999.1 Regulation governing the importation of dates. (a) Definitions....

  16. 49 CFR Appendix E to Part 99 - Statutes Regulating Post-Employment Responsibilities of Government and Special Government Employees

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Statutes Regulating Post-Employment Responsibilities of Government and Special Government Employees E Appendix E to Part 99 Transportation Office of the Secretary of Transportation EMPLOYEE RESPONSIBILITIES AND CONDUCT Pt. 99, App. E Appendix E...

  17. 77 FR 30998 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Government...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-24

    ... Defense Acquisition Regulations System Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Government Property AGENCY: Defense Acquisition Regulations System, Department of... and Technical Information System,'' and is used when directed by the plant clearance officer. e....

  18. 78 FR 72878 - Revisions to Procedural Regulations Governing Filing, Indexing and Service by Oil Pipelines...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-04

    ... modified to be more descriptive. For more information, contact Aaron Kahn, Office of Energy Market... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Revisions to Procedural Regulations Governing Filing, Indexing and...

  19. 76 FR 6003 - Defense Federal Acquisition Regulation Supplement; Marking of Government-Furnished Property

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-02

    ... administrator or other responsible Government official during a property management system analysis or audit... partial, advance, progress, or performance-based payments; (G) Intellectual property or software; or (H... 252 Defense Federal Acquisition Regulation Supplements; Marking of Government-Furnished...

  20. Performance Government: Activating and Regulating the Self-Governing Capacities of Teachers and School Leaders

    ERIC Educational Resources Information Center

    O'Brien, Peter C.

    2015-01-01

    This article analyses "performance government" as an emergent form of rule in advanced liberal democracies. It discloses how teachers and school leaders in Australia are being governed by the practices of performance government which centre on the recently established Australian Institute for Teaching and School Leadership (AITSL) and…

  1. 75 FR 38675 - Federal Acquisition Regulation; FAR Case 2008-011, Government Property

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-02

    ...The Civilian Agency Acquisition Council and the Defense Acquisition Regulations Council (Councils) have agreed on a final rule amending the Federal Acquisition Regulation (FAR) to revise FAR part 45, Government Property, and its associated...

  2. 75 FR 22727 - Defense Federal Acquisition Regulation Supplement; Government-Assigned Serial Number Marking...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-30

    ... Regulation Supplement; Government- Assigned Serial Number Marking (DFARS Case 2008-D047) AGENCY: Defense.... SUMMARY: DoD proposes to amend the Defense Federal Acquisition Regulation Supplement (DFARS) to...

  3. Dimensions of Environmental Management: Legitimation of Government Regulation by Industrial Managers

    ERIC Educational Resources Information Center

    Rickson, Roy E.

    1977-01-01

    Examines the environmental management issue of government regulation of water use and waste processes. Discusses problems of establishing authority in the interorganizational network of industry-government relationships. Research data are presented from a three-year study of industry-government relationships and pollution abatement change by…

  4. 76 FR 12315 - Committees on Collaborative Governance, Regulation, Rulemaking, Judicial Review, and Adjudication

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-07

    ...; ] ADMINISTRATIVE CONFERENCE OF THE UNITED STATES Committees on Collaborative Governance, Regulation, Rulemaking... 20036; Telephone 202-480-2080. SUPPLEMENTARY INFORMATION: Committee on Collaborative Governance The Committee on Collaborative Governance will meet to consider a report by Professor James T. O'Reilly of...

  5. Government Legislation and Regulations in the United States

    EPA Science Inventory

    For centuries, customary or traditional laws have covered the use of biological resources throughout the world. As human population levels increase in all societies, voluntary actions governed by cultural practices are frequently insufficient to protect biodiversity, leading to...

  6. 76 FR 81362 - Regulations Governing the Performance of Actuarial Services Under the Employee Retirement Income...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-28

    ... published in the Federal Register on Thursday, March 31, 2011 (76 FR 17762). DATES: This correction is... ENROLLMENT OF ACTUARIES 20 CFR Part 901 RIN 1545-BC82 Regulations Governing the Performance of Actuarial...--REGULATIONS GOVERNING THE PERFORMANCE OF ACTUARIAL SERVICES UNDER THE EMPLOYEE RETIREMENT INCOME SECURITY...

  7. 78 FR 62362 - Revisions to Procedural Regulations Governing Transportation by Intrastate Pipelines; Electronic...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-21

    ... Sarikas, Office of Energy Market Regulation at (202) 502-6831 or send an email to FERConline@ferc.gov... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Revisions to Procedural Regulations Governing Transportation by...

  8. 14 CFR 221.61 - Rules and regulations governing foreign air transportation.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Rules and regulations governing foreign air transportation. 221.61 Section 221.61 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS TARIFFS Governing Tariffs § 221.61 Rules and...

  9. 46 CFR 30.01-10 - Application of regulations governing alterations or repairs-TB/ALL.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Application of regulations governing alterations or repairs-TB/ALL. 30.01-10 Section 30.01-10 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS GENERAL PROVISIONS Administration § 30.01-10 Application of regulations governing alterations...

  10. Governance.

    ERIC Educational Resources Information Center

    Academe, 1989

    1989-01-01

    Over the last 75 years the AAUP has made progress in specifying its standards of governance and in reconciling traditional governance with collective bargaining. Excerpts from the "Joint Statement on Government of Colleges and Universities" and the "Statement on Academic Government for Institutions Engaged in Collective Bargaining" are presented.…

  11. 7 CFR 301.91-4 - Conditions governing the interstate movement of regulated articles from regulated areas in...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 5 2012-01-01 2012-01-01 false Conditions governing the interstate movement of regulated articles from regulated areas in quarantined States. 2 301.91-4 Section 301.91-4 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE DOMESTIC...

  12. 77 FR 12937 - Federal Acquisition Regulation; Government Property

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-02

    ... INFORMATION: I. Background DoD, GSA, and NASA published a proposed rule in the Federal Register at 76 FR 18497...)(i), ``in consultation with the Property Administrator,'' and retain existing language at (j)(2). Add...)(v)(A). The language regarding the management of Government property in subcontractors' possession...

  13. Government and Campus: Federal Regulation of Religiously Affiliated Higher Education.

    ERIC Educational Resources Information Center

    Gaffney, Edward McGlynn, Jr.; Moots, Philip R.

    Federal regulation of church-related colleges and universities was studied. Usable responses were received from 210 of 800 church-related institutions concerning the role of religion in everyday life of the institutions and the particular problems created for them by federal regulation. A legal analysis is presented of the major problems that…

  14. Government Regulation of the Pursuit of Knowledge: The Recombinant DNA Controversy.

    ERIC Educational Resources Information Center

    Berger, Richard G.

    1978-01-01

    Government regulation of recombinant DNA research is addressed. Issues discussed include the potential of such research; National Institutes of Health guidelines; federal, state, and local regulation; the controversy over self-regulation; first amendment protection for scientific research; and problems in drafting legislation. (JMD)

  15. 7 CFR 999.200 - Regulation governing the importation of prunes.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 8 2014-01-01 2014-01-01 false Regulation governing the importation of prunes. 999.200 Section 999.200 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE SPECIALTY CROPS; IMPORT REGULATIONS §...

  16. 7 CFR 999.200 - Regulation governing the importation of prunes.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 8 2013-01-01 2013-01-01 false Regulation governing the importation of prunes. 999.200 Section 999.200 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE SPECIALTY CROPS; IMPORT REGULATIONS §...

  17. 32 CFR 700.857 - Safe navigation and regulations governing operation of ships and aircraft.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 5 2010-07-01 2010-07-01 false Safe navigation and regulations governing operation of ships and aircraft. 700.857 Section 700.857 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY UNITED STATES NAVY REGULATIONS AND OFFICIAL RECORDS UNITED STATES NAVY REGULATIONS AND OFFICIAL RECORDS The...

  18. 7 CFR 999.1 - Regulation governing the importation of dates.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Regulation governing the importation of dates. 999.1 Section 999.1 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE SPECIALTY CROPS; IMPORT REGULATIONS §...

  19. State Laws and Regulations Governing Teachers Certificates. Bulletin, 1921, No. 22

    ERIC Educational Resources Information Center

    Cook, Katherine M.

    1921-01-01

    This study is intended to present information as complete as possible concerning the laws and regulations which govern the issue of teachers' certificates in the United States in so far as they are regulated by State legislation or State administrative departments. Licenses to teach issued by city boards in accordance with regulations prescribed…

  20. 25 CFR 1000.220 - What regulations apply to self-governance Tribes?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 2 2011-04-01 2011-04-01 false What regulations apply to self-governance Tribes? 1000.220 Section 1000.220 Indians OFFICE OF THE ASSISTANT SECRETARY, INDIAN AFFAIRS, DEPARTMENT OF THE...-DETERMINATION AND EDUCATION ACT Waiver of Regulations § 1000.220 What regulations apply to...

  1. 25 CFR 1000.220 - What regulations apply to self-governance Tribes?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 2 2012-04-01 2012-04-01 false What regulations apply to self-governance Tribes? 1000.220 Section 1000.220 Indians OFFICE OF THE ASSISTANT SECRETARY, INDIAN AFFAIRS, DEPARTMENT OF THE...-DETERMINATION AND EDUCATION ACT Waiver of Regulations § 1000.220 What regulations apply to...

  2. 25 CFR 1000.220 - What regulations apply to self-governance Tribes?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 2 2014-04-01 2014-04-01 false What regulations apply to self-governance Tribes? 1000.220 Section 1000.220 Indians OFFICE OF THE ASSISTANT SECRETARY, INDIAN AFFAIRS, DEPARTMENT OF THE...-DETERMINATION AND EDUCATION ACT Waiver of Regulations § 1000.220 What regulations apply to...

  3. 25 CFR 1000.220 - What regulations apply to self-governance Tribes?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 2 2013-04-01 2013-04-01 false What regulations apply to self-governance Tribes? 1000.220 Section 1000.220 Indians OFFICE OF THE ASSISTANT SECRETARY, INDIAN AFFAIRS, DEPARTMENT OF THE...-DETERMINATION AND EDUCATION ACT Waiver of Regulations § 1000.220 What regulations apply to...

  4. 25 CFR 1000.220 - What regulations apply to self-governance Tribes?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false What regulations apply to self-governance Tribes? 1000.220 Section 1000.220 Indians OFFICE OF THE ASSISTANT SECRETARY, INDIAN AFFAIRS, DEPARTMENT OF THE...-DETERMINATION AND EDUCATION ACT Waiver of Regulations § 1000.220 What regulations apply to...

  5. Cell fate regulation governed by a repurposed bacterial histidine kinase

    SciTech Connect

    Childers, W. Seth; Xu, Qingping; Mann, Thomas H.; Mathews, Irimpan I.; Blair, Jimmy A.; Deacon, Ashley M.; Shapiro, Lucy; Stock, Ann M.

    2014-10-28

    One of the simplest organisms to divide asymmetrically is the bacterium Caulobacter crescentus. The DivL pseudo-histidine kinase, positioned at one cell pole, regulates cell-fate by controlling the activation of the global transcription factor CtrA via an interaction with the response regulator (RR) DivK. DivL uniquely contains a tyrosine at the histidine phosphorylation site, and can achieve these regulatory functions in vivo without kinase activity. Determination of the DivL crystal structure and biochemical analysis of wild-type and site-specific DivL mutants revealed that the DivL PAS domains regulate binding specificity for DivK~P over DivK, which is modulated by an allosteric intramolecular interaction between adjacent domains. We discovered that DivL's catalytic domains have been repurposed as a phosphospecific RR input sensor, thereby reversing the flow of information observed in conventional histidine kinase (HK)-RR systems and coupling a complex network of signaling proteins for cell-fate regulation.

  6. Cell Fate Regulation Governed by a Repurposed Bacterial Histidine Kinase

    PubMed Central

    Mann, Thomas H.; Mathews, Irimpan I.; Blair, Jimmy A.; Deacon, Ashley M.; Shapiro, Lucy

    2014-01-01

    One of the simplest organisms to divide asymmetrically is the bacterium Caulobacter crescentus. The DivL pseudo-histidine kinase, positioned at one cell pole, regulates cell-fate by controlling the activation of the global transcription factor CtrA via an interaction with the response regulator (RR) DivK. DivL uniquely contains a tyrosine at the histidine phosphorylation site, and can achieve these regulatory functions in vivo without kinase activity. Determination of the DivL crystal structure and biochemical analysis of wild-type and site-specific DivL mutants revealed that the DivL PAS domains regulate binding specificity for DivK∼P over DivK, which is modulated by an allosteric intramolecular interaction between adjacent domains. We discovered that DivL's catalytic domains have been repurposed as a phosphospecific RR input sensor, thereby reversing the flow of information observed in conventional histidine kinase (HK)-RR systems and coupling a complex network of signaling proteins for cell-fate regulation. PMID:25349992

  7. Cell fate regulation governed by a repurposed bacterial histidine kinase

    DOE PAGESBeta

    Childers, W. Seth; Xu, Qingping; Mann, Thomas H.; Mathews, Irimpan I.; Blair, Jimmy A.; Deacon, Ashley M.; Shapiro, Lucy; Stock, Ann M.

    2014-10-28

    One of the simplest organisms to divide asymmetrically is the bacterium Caulobacter crescentus. The DivL pseudo-histidine kinase, positioned at one cell pole, regulates cell-fate by controlling the activation of the global transcription factor CtrA via an interaction with the response regulator (RR) DivK. DivL uniquely contains a tyrosine at the histidine phosphorylation site, and can achieve these regulatory functions in vivo without kinase activity. Determination of the DivL crystal structure and biochemical analysis of wild-type and site-specific DivL mutants revealed that the DivL PAS domains regulate binding specificity for DivK~P over DivK, which is modulated by an allosteric intramolecular interactionmore » between adjacent domains. We discovered that DivL's catalytic domains have been repurposed as a phosphospecific RR input sensor, thereby reversing the flow of information observed in conventional histidine kinase (HK)-RR systems and coupling a complex network of signaling proteins for cell-fate regulation.« less

  8. 75 FR 38765 - Domestic Origin Verification System Questionnaire and Regulations Governing Inspection and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-06

    ..., container number, country of origin, customs entry number, bill of lading number, broker reference number... Agricultural Marketing Service Domestic Origin Verification System Questionnaire and Regulations Governing... submitting the comments will be made public. SUPPLEMENTARY INFORMATION: Title: ``Domestic Origin...

  9. 76 FR 64885 - Defense Federal Acquisition Regulation Supplement: Reporting of Government-Furnished Property...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-19

    ...DoD is proposing to amend the Defense Federal Acquisition Regulation Supplement (DFARS) to revise and expand reporting requirements for Government-furnished property to include items uniquely and non-uniquely identified and clarify policy for contractor access to Government supply...

  10. 75 FR 40754 - Government in the Sunshine Act Regulations of the National Science Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-14

    ... From the Federal Register Online via the Government Publishing Office NATIONAL SCIENCE FOUNDATION 45 CFR Part 614 RIN 3145-AA53 Government in the Sunshine Act Regulations of the National Science Board AGENCY: National Science Board (NSB), National Science Foundation (NSF). ACTION: Direct final...

  11. 26 CFR 1.892-3T - Income of foreign governments (temporary regulations).

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 9 2011-04-01 2011-04-01 false Income of foreign governments (temporary regulations). 1.892-3T Section 1.892-3T Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Miscellaneous Provisions § 1.892-3T Income of foreign governments...

  12. 75 FR 8329 - Regulations Governing the Conduct of Open Seasons for Alaska Natural Gas Transportation Projects...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-24

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Regulations Governing the Conduct of Open Seasons for Alaska Natural Gas Transportation Projects; Notice of Rescheduled Alaska Natural Gas Transportation Projects Open Season Pre-Filing Workshop February 17, 2010....

  13. 76 FR 11985 - Defense Federal Acquisition Regulation Supplement; Reporting of Government-Furnished Property

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-04

    ...DoD is proposing to amend the Defense Federal Acquisition Regulation Supplement (DFARS) to revise and expand reporting requirements for Government-furnished property to include items uniquely and non-uniquely identified, and to clarify policy for contractor access to Government supply...

  14. 75 FR 3395 - Migratory Bird Permits; Changes in the Regulations Governing Falconry

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-21

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF THE INTERIOR Fish and Wildlife Service 50 CFR Parts 21 and 22 RIN 1018-AW44 Migratory Bird Permits; Changes in the Regulations Governing Falconry Correction In rule document 2010-12 beginning on page 927 in the issue...

  15. How State and Local Governments Regulate Economic Activities: A Consumer Briefing.

    ERIC Educational Resources Information Center

    Nelson, Helen E.

    This paper depicts some of the ways State and local governments define, regulate, and police the communities and markets where consumers convert their income into a way of life. Explained are how regulatory processes are developed in State and local government, what the underlying concepts are, and some of the access points for fruitful citizen…

  16. Governing childhood obesity: framing regulation of fast food advertising in the Australian print media.

    PubMed

    Henderson, Julie; Coveney, John; Ward, Paul; Taylor, Anne

    2009-11-01

    Childhood obesity is widely constructed as reaching epidemic proportions with consumption of fast food viewed as a contributing factor. This paper analyses media reporting of the regulation of fast food consumption to children. A media search of five Australian newspapers for the period January 2006 to June 2008 elicited 100 articles relating to the regulation of fast food advertising to children. Content and thematic analysis of the articles reveal conflicting perspectives on the role of the state; the level of accountability of the food and advertising industries; and responsibilities of parents for regulating fast food consumption in children. The Federal Government, food and advertising industries and free to air broadcasters favour industry self-regulation and personal responsibility for fast food consumption while the proponents of government regulation include consumer groups, state government health ministers, nutrition and public health academics and medical and health foundations. The regulation of fast food advertising to children is discussed in relation to ideas about governance and the public health strategies which follow from these ideas. The paper argues that all proposed solutions are indicative of a neoliberal approach to the governance of health insofar as the responsibility for regulation of food marketing is viewed as lying with industry and the regulation of lifestyle risk is viewed as an individual responsibility. PMID:19758736

  17. Improving government regulations: a guidebook for conservation and renewable energy

    SciTech Connect

    Neese, R. J.; Scheer, R. M.; Marasco, A. L.

    1981-04-01

    An integrated view of the Office of Conservation and Solar Energy (CS) policy making encompassing both administrative procedures and policy analysis is presented. Chapter One very briefly sketches each step in the development of a significant regulation, noting important requirements and participants. Chapter Two expands upon the Overview, providing the details of the process, the rationale and source of requirements, concurrence procedures, and advice on the timing and synchronization of steps. Chapter Three explains the types of analysis documents that may be required for a program. Regulatory Analyses, Environmental Impact Statements, Urban and Community Impact Analyses, and Regulatory Flexibility Analyses are all discussed. Specific information to be included in the documents and the circumstances under which the documents need to be prepared are explained. Chapter Four is a step-by-step discussion of how to do good analysis. Use of models and data bases is discussed. Policy objectives, alternatives, and decision making are explained. In Chapter five guidance is provided on identifying the public that would most likely be interested in the regulation, involving its constituents in a dialogue with CS, evaluating and handling comments, and engineering the final response. Chapter Six provides direction on planning the evaluation, monitoring the regulation's success once it has been promulgated, and allowing for constructive support or criticism from outside DOE. (MCW)

  18. 20 CFR 220.37 - When a child's disability determination is governed by the regulations of the Social Security...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... governed by the regulations of the Social Security Administration. 220.37 Section 220.37 Employees... Disability Determinations Governed by the Regulations of the Social Security Administration § 220.37 When a child's disability determination is governed by the regulations of the Social Security...

  19. 20 CFR 220.37 - When a child's disability determination is governed by the regulations of the Social Security...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... governed by the regulations of the Social Security Administration. 220.37 Section 220.37 Employees... Disability Determinations Governed by the Regulations of the Social Security Administration § 220.37 When a child's disability determination is governed by the regulations of the Social Security...

  20. 20 CFR 220.37 - When a child's disability determination is governed by the regulations of the Social Security...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... governed by the regulations of the Social Security Administration. 220.37 Section 220.37 Employees... Disability Determinations Governed by the Regulations of the Social Security Administration § 220.37 When a child's disability determination is governed by the regulations of the Social Security...

  1. 20 CFR 220.37 - When a child's disability determination is governed by the regulations of the Social Security...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... governed by the regulations of the Social Security Administration. 220.37 Section 220.37 Employees... Disability Determinations Governed by the Regulations of the Social Security Administration § 220.37 When a child's disability determination is governed by the regulations of the Social Security...

  2. 20 CFR 220.37 - When a child's disability determination is governed by the regulations of the Social Security...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... governed by the regulations of the Social Security Administration. 220.37 Section 220.37 Employees... Disability Determinations Governed by the Regulations of the Social Security Administration § 220.37 When a child's disability determination is governed by the regulations of the Social Security...

  3. 43 CFR 3270.10 - What types of geothermal operations are governed by these utilization regulations?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false What types of geothermal operations are governed by these utilization regulations? 3270.10 Section 3270.10 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) GEOTHERMAL RESOURCE...

  4. 7 CFR 351.7 - Regulations governing importation by mail of plant material for immediate export.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 5 2012-01-01 2012-01-01 false Regulations governing importation by mail of plant material for immediate export. 351.7 Section 351.7 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE IMPORTATION OF PLANTS OR PLANT PRODUCTS BY MAIL §...

  5. 76 FR 81362 - Regulations Governing the Performance of Actuarial Services Under the Employee Retirement Income...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-28

    ..., 2011 (76 FR 17762) relating to the enrollment of actuaries. DATES: This correction is effective on..., the publication of the final regulations (TD 9517) which were the subject of FR Doc. 2011-7573 is... ENROLLMENT OF ACTUARIES 20 CFR Part 901 RIN 1545-BC82 Regulations Governing the Performance of...

  6. 76 FR 9527 - Defense Federal Acquisition Regulation Supplement; Reporting of Government-Furnished Property...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-18

    .... Background DoD published a proposed rule in the Federal Register on December 22, 2010 (75 FR 80426), with a... Regulation Supplement; Reporting of Government-Furnished Property (DFARS Case 2009-D043) AGENCY: Defense... period. SUMMARY: DoD is proposing to amend the Defense Federal Acquisition Regulation Supplement...

  7. 43 CFR 1812.1-1 - Regulations governing practice before the Department.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Department. 1812.1-1 Section 1812.1-1 Public Lands: Interior Regulations Relating to Public Lands (Continued... GUIDANCE Qualifications of Practitioners § 1812.1-1 Regulations governing practice before the Department..., must comply with the requirements of part 1 of this title....

  8. 43 CFR 1812.1-1 - Regulations governing practice before the Department.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Department. 1812.1-1 Section 1812.1-1 Public Lands: Interior Regulations Relating to Public Lands (Continued... GUIDANCE Qualifications of Practitioners § 1812.1-1 Regulations governing practice before the Department..., must comply with the requirements of part 1 of this title....

  9. 43 CFR 1812.1-1 - Regulations governing practice before the Department.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Department. 1812.1-1 Section 1812.1-1 Public Lands: Interior Regulations Relating to Public Lands (Continued... GUIDANCE Qualifications of Practitioners § 1812.1-1 Regulations governing practice before the Department..., must comply with the requirements of part 1 of this title....

  10. Governance.

    ERIC Educational Resources Information Center

    Moran, K. D.

    The author notes that two trends appear to be developing in litigation over the governance of the public schools. One trend is increasing participation of organized groups in suits against the schools. The other is a greater volume of litigation dealing with open meeting laws and freedom of information acts. Reflecting the second trend, the…

  11. Government regulations and other influences on the medical use of computers.

    PubMed

    Mishelevich, D J; Grams, R R; Mize, S G; Smith, J P

    1979-01-01

    This paper presents points brought out in a panel discussion held at the 12th Hawaiian International Conference on System Sciences, January 1979. The session was attended by approximately two dozen interested parties from various segments of the academic, government, and health care communities. The broad categories covered include the specific problems of government regulations and their impact on specific clinical information systems installed at The University of Texas Health Science Center at Dallas, opportunities in a regulated environment, problems in a regulated environment, vendor-related issues in the marketing and manufacture of computer-based information systems, rational approaches to government control, and specific issues related to medical computer science. PMID:548568

  12. 75 FR 927 - Migratory Bird Permits; Changes in the Regulations Governing Falconry

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-07

    ... Federal Register (73 FR 59448) to revise our regulations governing falconry in the United States. We... (75 FR 36158) to clarify or correct some provisions in the rule. Comments on the Proposed Rule We... falconer uses their bird in a Harry Potter movie, but the potential problems in that space are...

  13. 76 FR 46628 - Regulations Governing Fees for Services Performed in Connection With Licensing and Related...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-03

    ... Surface Transportation Board 49 CFR Part 1002 Regulations Governing Fees for Services Performed in Connection With Licensing and Related Services--2011 Update AGENCY: Surface Transportation Board. ACTION... proceedings $250. (61)(i) An appeal of a Surface Transportation Board $250. decision on the merits or...

  14. 75 FR 44158 - Regulations Governing Fees for Services Performed in Connection With Licensing and Related...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-28

    ... Surface Transportation Board 49 CFR Part 1002 Regulations Governing Fees for Services Performed in Connection With Licensing and Related Services--2010 Update AGENCY: Surface Transportation Board, DOT. ACTION... Surface $250. Transportation Board decision on the merits or petition to revoke an exemption pursuant...

  15. 34 CFR 655.1 - Which programs do these regulations govern?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... the Higher Education Act of 1965, as amended); (b) The Language Resource Centers Program (section 603... International Research and Studies Program (section 605); and (e) The Business and International Education... 34 Education 3 2011-07-01 2011-07-01 false Which programs do these regulations govern?...

  16. 75 FR 6370 - Regulations Governing the Conduct of Open Seasons for Alaska Natural Gas Transportation Projects...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-09

    ... Energy Regulatory Commission Regulations Governing the Conduct of Open Seasons for Alaska Natural Gas Transportation Projects; Notice of Alaska Natural Gas Transportation Projects Open Season Pre-Filing Workshop... hold a workshop on the procedures and process for holding and commenting on an open season for...

  17. 26 CFR 1.892-2T - Foreign government defined (temporary regulations).

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 9 2011-04-01 2011-04-01 false Foreign government defined (temporary regulations). 1.892-2T Section 1.892-2T Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY... in turn invests such contributions partially in United States Treasury obligations. The income of...

  18. 26 CFR 1.892-2T - Foreign government defined (temporary regulations).

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 9 2013-04-01 2013-04-01 false Foreign government defined (temporary regulations). 1.892-2T Section 1.892-2T Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY... in turn invests such contributions partially in United States Treasury obligations. The income of...

  19. 26 CFR 1.892-2T - Foreign government defined (temporary regulations).

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 9 2010-04-01 2010-04-01 false Foreign government defined (temporary regulations). 1.892-2T Section 1.892-2T Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY... in turn invests such contributions partially in United States Treasury obligations. The income of...

  20. 26 CFR 1.892-2T - Foreign government defined (temporary regulations).

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 9 2012-04-01 2012-04-01 false Foreign government defined (temporary regulations). 1.892-2T Section 1.892-2T Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY... in turn invests such contributions partially in United States Treasury obligations. The income of...

  1. 26 CFR 1.892-2T - Foreign government defined (temporary regulations).

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 9 2014-04-01 2014-04-01 false Foreign government defined (temporary regulations). 1.892-2T Section 1.892-2T Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY... in turn invests such contributions partially in United States Treasury obligations. The income of...

  2. 75 FR 15336 - Regulations Governing the Conduct of Open Seasons for Alaska Natural Gas Transportation Projects

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-29

    ...The Commission is amending its regulations, in order to clarify them in response to Order Nos. 717 and 717- A, governing the Standards of Conduct for transmission providers. These amendments are required in order to make clear to prospective applicants for an Alaska natural gas transportation project which Standards of Conduct are applicable to conducting open seasons for Alaska natural gas......

  3. 78 FR 53055 - Regulations Governing Fees for Services Performed in Connection With Licensing and Related...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-28

    ... Surface Transportation Board 49 CFR Part 1002 Regulations Governing Fees for Services Performed in Connection With Licensing and Related Services--2013 Update AGENCY: Surface Transportation Board, DOT. ACTION... Officer, Room 1200, Surface Transportation Board, Washington, DC 20423- 0001. * * * * * 0 3. In Sec....

  4. 75 FR 29917 - Migratory Bird Permits; Changes in the Regulations Governing Migratory Bird Rehabilitation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-28

    ... FR 61123) to establish regulations for the issuance of permits to rehabilitate migratory birds in the... Relations with Native American Tribal Governments'' (59 FR 22951), Executive Order 13175, and 512 DM 2, we... Fish and Wildlife Service 50 CFR Part 21 RIN 1018-AX09 Migratory Bird Permits; Changes in...

  5. 76 FR 71823 - Defense Federal Acquisition Regulation Supplement: Responsibility and Liability for Government...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-18

    ... Regulation Supplement: Responsibility and Liability for Government Property (DFARS Case 2010-D018) AGENCY.... SUPPLEMENTARY INFORMATION: I. Background DoD published a proposed rule at 76 FR 21852 on April 19, 2011. Twenty... responsibility for all costs and resulting profit and loss. The FAR already provides that contractors are...

  6. 76 FR 52139 - Defense Federal Acquisition Regulation Supplement; Government; Property (DFARS Case 2009-D008)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-19

    ... changes to FAR subparts 45.6 and 45.7, published in the Federal Register at 72 FR 27364 on May 15, 2007. A proposed DFARS rule was published in the Federal Register at 75 FR 75444 on December 3, 2010. The public... Acquisition Regulation Supplement; Government; Property (DFARS Case 2009-D008) AGENCY: Defense...

  7. 76 FR 11190 - Defense Federal Acquisition Regulation Supplement; Reporting of Government-Furnished Property...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-01

    ... published a proposed rule in the Federal Register on December 22, 2010 (75 FR 80427). DoD published an extension of the public comment period on February 18, 2011 (75 FR 9527). The public comment period ends on... Acquisition Regulation Supplement; Reporting of Government-Furnished Property (DFARS Case 2009-D043)...

  8. Limiting the Influence of Pharmaceutical Industry Gifts on Physicians: Self-Regulation or Government Intervention?

    PubMed Central

    2009-01-01

    Concerns over the influence of pharmaceutical gifts on physicians have surged in recent years. This has prompted wide ranging legislative proposals in numerous states and in the federal government as well as stepped up efforts at self-regulation by the pharmaceutical industry and the medical profession. Policymakers face the decision of whether to defer to self-regulation or support government intervention. This commentary describes efforts at self-regulation by the pharmaceutical industry and the medical profession. The author examines and critiques the wide ranging legislative strategies pursued to limit the influence of pharmaceutical gifts on physicians and concludes with suggestions for policymakers and the profession to limit influence and preserve public trust. PMID:19756874

  9. Limiting the influence of pharmaceutical industry gifts on physicians: self-regulation or government intervention?

    PubMed

    Grande, David

    2010-01-01

    Concerns over the influence of pharmaceutical gifts on physicians have surged in recent years. This has prompted wide ranging legislative proposals in numerous states and in the federal government as well as stepped up efforts at self-regulation by the pharmaceutical industry and the medical profession. Policymakers face the decision of whether to defer to self-regulation or support government intervention. This commentary describes efforts at self-regulation by the pharmaceutical industry and the medical profession. The author examines and critiques the wide ranging legislative strategies pursued to limit the influence of pharmaceutical gifts on physicians and concludes with suggestions for policymakers and the profession to limit influence and preserve public trust. PMID:19756874

  10. Participatory health impact assessment for the development of local government regulation on hazard control

    SciTech Connect

    Inmuong, Uraiwan; Rithmak, Panee; Srisookwatana, Soomol; Traithin, Nathathai; Maisuporn, Pornpun

    2011-07-15

    The Thai Public Health Act 1992 required the Thai local governments to issue respective regulations to take control of any possible health-hazard related activities, both from commercial and noncommercial sources. Since 1999, there has been centrally decentralized of power to a new form of local government establishment, namely Sub-district Administrative Organization (SAO). The SAO is asmall-scale local governing structure while its legitimate function is for community services, including control of health impact related activities. Most elected SAO administrators and officers are new and less experience with any of public health code of practice, particularly on health-hazard control. This action research attempted to introduce and apply a participatory health impact assessment (HIA) tool for the development of SAO health-hazard control regulation. The study sites were at Ban Meang and Kok See SAOs, Khon Kaen Province, Thailand, while all intervention activities conducted during May 2005-April 2006. A set of cooperative activities between researchers and community representatives were planned and organized by; surveying and identifying place and service base locally causing local environmental health problems, organizing community participatory workshops for drafting and proposing the health-hazard control regulation, and appropriate practices for health-hazard controlling measures. This action research eventually could successfully enable the SAO administrators and officers understanding of local environmental-related health problem, as well as development of imposed health-hazard control regulation for local community.

  11. United States Government Regulations and International Standards Related to Food Analysis

    NASA Astrophysics Data System (ADS)

    Nielsen, S. Suzanne

    Knowledge of government regulations relevant to the chemical analysis of foods is extremely important to persons working in the food industry. Federal laws and regulations reinforce the efforts of the food industry to provide wholesome foods, to inform consumers about the nutritional composition of foods, and to eliminate economic frauds. In some cases, they dictate what ingredients a food must contain, what must be tested, and the procedures used to analyze foods for safety factors and quality attributes. This chapter describes the US federal regulations related to the composition of foods. The reader is referred to references (1-4) for comprehensive coverage of US food laws and regulations. Many of the regulations referred to in this chapter are published in the various titles of the Code of Federal Regulations (CFR) (5). This chapter also includes information about food standards and safety practices established by international organizations. Internet addresses are given at the end of this chapter for many of the government agencies, organizations, and documents discussed.

  12. 36 CFR 251.14 - Conditions, rules and regulations to govern exercise of timber rights reserved in conveyance to...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... regulations to govern exercise of timber rights reserved in conveyance to the United States. 251.14 Section... Miscellaneous Land Uses Natural Resources Control § 251.14 Conditions, rules and regulations to govern exercise... undertakes to exercise the reserved rights, hereinafter called operator, shall give prior written notice...

  13. 36 CFR 251.14 - Conditions, rules and regulations to govern exercise of timber rights reserved in conveyance to...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... regulations to govern exercise of timber rights reserved in conveyance to the United States. 251.14 Section... Miscellaneous Land Uses Natural Resources Control § 251.14 Conditions, rules and regulations to govern exercise... undertakes to exercise the reserved rights, hereinafter called operator, shall give prior written notice...

  14. 36 CFR 251.15 - Conditions, rules and regulations to govern exercise of mineral rights reserved in conveyances to...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... regulations to govern exercise of mineral rights reserved in conveyances to the United States. 251.15 Section... Miscellaneous Land Uses Natural Resources Control § 251.15 Conditions, rules and regulations to govern exercise... obedience thereto: (1) Whoever undertakes to exercise the reserved rights shall give prior written notice...

  15. The Impact of Government Regulations on Early Childhood Services: Perceptions of Early Childhood Professionals in the South West of England.

    ERIC Educational Resources Information Center

    Rodd, Jillian

    1999-01-01

    Interviewed 24 early-childhood service managers to study impact of government regulations on daily practices within a range of early-childhood services in southwest England. Found that the majority of respondents considered government regulations to be related to meeting minimum standards rather than to quality assurance and were confused about…

  16. Governance strategies for living technologies: bridging the gap between stimulating and regulating technoscience.

    PubMed

    van Est, Rinie; Stemerding, Dirk

    2013-01-01

    The life sciences present a politically and ethically sensitive area of technology development. NBIC convergence-the convergence of nanotechnology, biotechnology, and information and cognitive technology-presents an increased interaction between the biological and physical sciences. As a result the bio-debate is no longer dominated by biotechnology, but driven by NBIC convergence. NBIC convergence enables two bioengineering megatrends: "biology becoming technology" and "technology becoming biology." The notion of living technologies captures the latter megatrend. Accordingly, living technology presents a politically and ethically sensitive area. This implies that governments sooner or later are faced with the challenge of both promoting and regulating the development of living technology. This article describes four current political models to deal with innovation promotion and risk regulation. Based on two specific developments in the field of living technologies-(psycho)physiological computing and synthetic biology-we reflect on appropriate governance strategies for living technologies. We conclude that recent pleas for anticipatory and deliberative governance tend to neglect the need for anticipatory regulation as a key factor in guiding the development of the life sciences from a societal perspective. In particular, when it is expected that a certain living technology will radically challenge current regulatory systems, one should opt for just such a more active biopolitical approach. PMID:23834596

  17. Impact of government regulations on leadtimes of coal facilities. Final report

    SciTech Connect

    Singh, J.; Carboni, J.V.; Shah, D.V.; White, J.M. Jr.

    1980-08-01

    The ability of the US to increase coal use depends on the leadtimes required to bring from inception into operation: (1) new coal use facilities such as powerplants, industrial boilers, coke ovens, and coal-based synfuel plants; and (2) new coal facilities including surface mines, deep mines, coal preparation plants, and railroad lines. This study examines the effect of government regulations on the leadtimes for the following ten facilities: surface mines on federal land; surface mines - private surface/private coal; underground coal mines; coal preparation plants; railroad lines; coal-fired electric generating plants; coal-fired industrial facilities; coke plants; synthetic fuels; and transmission lines. Environmental activities consume a significant portion of critical path time for all facilities. The time spent for obtaining permits and licenses account for as much as 63% of total critical path time in the case of a new railroad line servicing a coal mine in the western US. For surface mines, permitting accounts for 33% of total project critical path; for underground mines, it is 43%. Permitting requires 26 and 42% of the critical paths for new industrial facilities and power plants, respectively. Long durations of critical environmental activities account for much of the uncertainty surrounding the approval of large coal projects. Government regulations have also affected the way companies conduct their business. Dealing with government regulations has become as important to the completion of new coal facilities as project financing, design, and construction.

  18. Government regulation of gambling advertising: Replacing vice prevention with consumer protection.

    PubMed

    Rothman, M; Robbins, H

    1991-12-01

    From 1895 to 1975, federal law forbade gambling advertising by use of the mail, interstate commerce, and the broadcast media. Congress exempted state lotteries in 1975 and charitable gambling (including casino games) in 1988. However, the Supreme Court requires a significant government interest, directly applied and narrowly tailored, in order to justify a commercial speech regulation. The exemptions for private charity casino games has arguably destroyed any constitutionally defensible government interest in restricting for-profit casinos. Casinos in new gambling jurisdictions (such as Iowa or Illinois) will probably push the hardest for an exemption for all legal gambling, as they have the most to gain from the freedom to advertise. Federal regulation of gambling advertising will fall to the Federal Trade Commission under prohibitions against "unfair or deceptive" trade practices. But as State regulations are not well developed even in states that permit casino gambling, there is a pressing need for new research to review state laws regulating gambling advertising and to propose a model statute. PMID:24243220

  19. [Changes in the regulation and government of the health system. SESPAS report 2014].

    PubMed

    Repullo, José R

    2014-06-01

    The economic and fiscal crisis of 2008 has erupted into the debate on the sustainability of health systems; some countries, such as Spain, have implemented strong policies of fiscal consolidation and austerity. The institutional framework and governance model of the national health system (NHS) after its devolution to regions in 2002 had significant weaknesses, which were not apparent in the rapid growth stage but which have been clearly visible since 2010. In this article, we describe the changes in government regulation from the national and NHS perspective: both general changes (clearly prompted by the economic authorities), and those more specifically addressed to healthcare. The Royal Decree-Law 16/2012 represents the centerpiece of austerity policies in healthcare but also implies a rupture with existing political consensus and a return to social security models. Our characterization of austerity in healthcare explores impacts on savings, services, and on the healthcare model itself, although the available information only allows some indications. The conclusions highlight the need to change the path of linear, rapid and radical budget cuts, providing a time-frame for implementing key reforms in terms of internal sustainability; to do so, it is appropriate to restore political and institutional consensus, to emphasize "clinical management" and divestment of inappropriate services (approach to the medical profession and its role as micro-manager), and to create frameworks of good governance and organizational innovations that support these structural reforms. PMID:24863996

  20. AMPK governs lineage specification through Tfeb-dependent regulation of lysosomes

    PubMed Central

    Young, Nathan P.; Kamireddy, Anwesh; Van Nostrand, Jeanine L.; Eichner, Lillian J.; Shokhirev, Maxim Nikolaievich; Dayn, Yelena; Shaw, Reuben J.

    2016-01-01

    Faithful execution of developmental programs relies on the acquisition of unique cell identities from pluripotent progenitors, a process governed by combinatorial inputs from numerous signaling cascades that ultimately dictate lineage-specific transcriptional outputs. Despite growing evidence that metabolism is integrated with many molecular networks, how pathways that control energy homeostasis may affect cell fate decisions is largely unknown. Here, we show that AMP-activated protein kinase (AMPK), a central metabolic regulator, plays critical roles in lineage specification. Although AMPK-deficient embryonic stem cells (ESCs) were normal in the pluripotent state, these cells displayed profound defects upon differentiation, failing to generate chimeric embryos and preferentially adopting an ectodermal fate at the expense of the endoderm during embryoid body (EB) formation. AMPK−/− EBs exhibited reduced levels of Tfeb, a master transcriptional regulator of lysosomes, leading to diminished endolysosomal function. Remarkably, genetic loss of Tfeb also yielded endodermal defects, while AMPK-null ESCs overexpressing this transcription factor normalized their differential potential, revealing an intimate connection between Tfeb/lysosomes and germ layer specification. The compromised endolysosomal system resulting from AMPK or Tfeb inactivation blunted Wnt signaling, while up-regulating this pathway restored expression of endodermal markers. Collectively, these results uncover the AMPK pathway as a novel regulator of cell fate determination during differentiation. PMID:26944679

  1. 20 CFR 220.38 - When a widow(er)'s disability determination is governed by the regulations of the Social Security...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... is governed by the regulations of the Social Security Administration. 220.38 Section 220.38 Employees... Disability Determinations Governed by the Regulations of the Social Security Administration § 220.38 When a widow(er)'s disability determination is governed by the regulations of the Social...

  2. 20 CFR 220.38 - When a widow(er)'s disability determination is governed by the regulations of the Social Security...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... is governed by the regulations of the Social Security Administration. 220.38 Section 220.38 Employees... Disability Determinations Governed by the Regulations of the Social Security Administration § 220.38 When a widow(er)'s disability determination is governed by the regulations of the Social...

  3. 20 CFR 220.38 - When a widow(er)'s disability determination is governed by the regulations of the Social Security...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... governed by the regulations of the Social Security Administration. 220.38 Section 220.38 Employees... Disability Determinations Governed by the Regulations of the Social Security Administration § 220.38 When a widow(er)'s disability determination is governed by the regulations of the Social...

  4. 20 CFR 220.38 - When a widow(er)'s disability determination is governed by the regulations of the Social Security...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... governed by the regulations of the Social Security Administration. 220.38 Section 220.38 Employees... Disability Determinations Governed by the Regulations of the Social Security Administration § 220.38 When a widow(er)'s disability determination is governed by the regulations of the Social...

  5. 20 CFR 220.38 - When a widow(er)'s disability determination is governed by the regulations of the Social Security...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... is governed by the regulations of the Social Security Administration. 220.38 Section 220.38 Employees... Disability Determinations Governed by the Regulations of the Social Security Administration § 220.38 When a widow(er)'s disability determination is governed by the regulations of the Social...

  6. 7 CFR 301.85-3 - Conditions governing the interstate movement of regulated articles from quarantined States. 2

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... DOMESTIC QUARANTINE NOTICES Golden Nematode Quarantine and Regulations § 301.85-3 Conditions governing the... of the golden nematode and the person in possession thereof has been so notified; or (v) Through or... golden nematode exists; or (v) Through or reshipped from any regulated area if the articles...

  7. 10 CFR Appendix A to Part 603 - Applicable Federal Statutes, Executive Orders, and Government-wide Regulations

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Applicable Federal Statutes, Executive Orders, and Government-wide Regulations A Appendix A to Part 603 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS TECHNOLOGY INVESTMENT AGREEMENTS Pt. 603, App. A Appendix A to Part 603—Applicable Federal Statutes, Executive Orders, and...

  8. 7 CFR 301.74-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... DOMESTIC QUARANTINE NOTICES Plum Pox § 301.74-4 Conditions governing the interstate movement of regulated... Departmental permit and found by the Administrator to be adequate to prevent the spread of plum pox; and (4... plum pox while in the quarantined area; (2) The regulated article's point of origin is indicated on...

  9. 7 CFR 301.74-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... DOMESTIC QUARANTINE NOTICES Plum Pox § 301.74-4 Conditions governing the interstate movement of regulated... Departmental permit and found by the Administrator to be adequate to prevent the spread of plum pox; and (4... plum pox while in the quarantined area; (2) The regulated article's point of origin is indicated on...

  10. 7 CFR 301.74-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... DOMESTIC QUARANTINE NOTICES Plum Pox § 301.74-4 Conditions governing the interstate movement of regulated... Departmental permit and found by the Administrator to be adequate to prevent the spread of plum pox; and (4... plum pox while in the quarantined area; (2) The regulated article's point of origin is indicated on...

  11. 7 CFR 301.74-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... DOMESTIC QUARANTINE NOTICES Plum Pox § 301.74-4 Conditions governing the interstate movement of regulated... Departmental permit and found by the Administrator to be adequate to prevent the spread of plum pox; and (4... plum pox while in the quarantined area; (2) The regulated article's point of origin is indicated on...

  12. 7 CFR 301.74-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... DOMESTIC QUARANTINE NOTICES Plum Pox § 301.74-4 Conditions governing the interstate movement of regulated... Departmental permit and found by the Administrator to be adequate to prevent the spread of plum pox; and (4... plum pox while in the quarantined area; (2) The regulated article's point of origin is indicated on...

  13. A Position Paper on the Roles of Federal, State and Local Governments on Standards, Regulations and Laws for Day Care.

    ERIC Educational Resources Information Center

    Zaccaria, Michael A.; Hollomon, John W.

    The goals of this position paper are: (1) to describe some specific roles the federal state and local governments can play in regard to child care standards and regulations and (2) to make some straightforward and down-to-earth suggestions, which should undergird national child care standards and regulations, as these relate to day care. Some of…

  14. 7 CFR 301.86-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 5 2012-01-01 2012-01-01 false Conditions governing the interstate movement of regulated articles from quarantined areas. 301.86-4 Section 301.86-4 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE DOMESTIC QUARANTINE NOTICES Pale Cyst Nematode...

  15. 7 CFR 301.51-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... permit issued and attached in accordance with §§ 301.51-5 and 301.51-8; (2) Without a certificate or... regulated articles from quarantined areas. 301.51-4 Section 301.51-4 Agriculture Regulations of the... DOMESTIC QUARANTINE NOTICES Asian Longhorned Beetle § 301.51-4 Conditions governing the interstate...

  16. Spatial Regulation of Histidine Kinases Governing Biofilm Formation in Bacillus subtilis▿ †

    PubMed Central

    McLoon, Anna L.; Kolodkin-Gal, Ilana; Rubinstein, Shmuel M.; Kolter, Roberto; Losick, Richard

    2011-01-01

    Bacillus subtilis is able to form architecturally complex biofilms on solid medium due to the production of an extracellular matrix. A master regulator that controls the expression of the genes involved in matrix synthesis is Spo0A, which is activated by phosphorylation via a phosphorelay involving multiple histidine kinases. Here we report that four kinases, KinA, KinB, KinC, and KinD, help govern biofilm formation but that their contributions are partially masked by redundancy. We show that the kinases fall into two categories and that the members of each pair (one pair comprising KinA and KinB and the other comprising KinC and KinD) are partially redundant with each other. We also show that the kinases are spatially regulated: KinA and KinB are active principally in the older, inner regions of the colony, and KinC and KinD function chiefly in the younger, outer regions. These conclusions are based on the morphology of kinase mutants, real-time measurements of gene expression using luciferase as a reporter, and confocal microscopy using a fluorescent protein as a reporter. Our findings suggest that multiple signals from the older and younger regions of the colony are integrated by the kinases to determine the overall architecture of the biofilm community. PMID:21097618

  17. Oil on the water: Government regulation of a carcinogen in the twentieth-century Lancashire cotton spinning industry.

    PubMed

    Higgins, David; Tweedale, Geoffrey

    2010-01-01

    In the Lancashire cotton textile industry, mule spinners were prone to a chronic and sometimes fatal skin cancer (often affecting the groin). The disease had reached epidemic proportions by the 1920s, which necessitated action by the government, employers, and trade unions. In contrast to previous accounts, this article focuses on the government's reaction to mule spinners' cancer. Using official records in the National Archives, the slow introduction of health and safety measures by the government is explored in detail. Although obstructionism by the employers played a key role, one of the reasons for government inaction was the ambiguity of scientific research on engineering oils. On the other hand, prolonged scientific research suited a government policy that was framed around self regulation - a policy that had proved largely ineffective by the 1950s. PMID:20734570

  18. Private governance, public purpose? Assessing transparency and accountability in self-regulation of food advertising to children.

    PubMed

    Reeve, Belinda

    2013-06-01

    Reducing non-core food advertising to children is an important priority in strategies to address childhood obesity. Public health researchers argue for government intervention on the basis that food industry self-regulation is ineffective; however, the industry contends that the existing voluntary scheme adequately addresses community concerns. This paper examines the operation of two self-regulatory initiatives governing food advertising to children in Australia, in order to determine whether these regulatory processes foster transparent and accountable self-regulation. The paper concludes that while both codes appear to establish transparency and accountability mechanisms, they do not provide for meaningful stakeholder participation in the self-regulatory scheme. Accordingly, food industry self-regulation is unlikely to reflect public health concerns or to be perceived as a legitimate form of governance by external stakeholders. If industry regulation is to remain a feasible alternative to statutory regulation, there is a strong argument for strengthening government oversight and implementing a co-regulatory scheme. PMID:23585017

  19. 10 CFR Appendix A to Part 603 - Applicable Federal Statutes, Executive Orders, and Government-wide Regulations

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Government-wide common rule that the DOE has codified at 10 CFR part 601. The “List of Certifications and... Act of 1964 (42 U.S.C. 2000d, et seq.) as implemented by DOE regulations at 10 CFR part 1040. These... Discrimination Act of 1975 (42 U.S.C. 6101, et seq.) as implemented by DOE regulations at 10 CFR part 1040....

  20. 10 CFR Appendix A to Part 603 - Applicable Federal Statutes, Executive Orders, and Government-wide Regulations

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Government-wide common rule that the DOE has codified at 10 CFR part 601. The “List of Certifications and... Act of 1964 (42 U.S.C. 2000d, et seq.) as implemented by DOE regulations at 10 CFR part 1040. These... Discrimination Act of 1975 (42 U.S.C. 6101, et seq.) as implemented by DOE regulations at 10 CFR part 1040....

  1. Impact of government regulations on leadtimes of coal facilities. Final report

    SciTech Connect

    Not Available

    1980-08-01

    The ability of the US to increase coal use depends on the leadtimes required to bring from inception into operation: (1) new coal use facilities such as powerplants, industrial boilers, coke ovens, and coal-based synfuel plants; and (2) new coal facilities including surface mines, deep mines, coal preparation plants, and railroad lines. This study examines the effect of government regulations on the leadtimes for the following ten facilities: surface mines on federal land; surface mines - private surface/private coal; underground coal mines; coal preparation plants; railroad lines; coal-fired electric generating plants; coal-fired industrial facilities; coke plants; synthetic fuels; and transmission lines. These appendices contain summaries of legislation affecting the above coal facilities. Discussed are: the Clean Air Act; National Environmental Policy Act; Federal Coal Leasing Amendments Act; Surface Mining Control and Reclamation Act; Federal Land Policy and Management Act; River and Harbors Act; Federal Mine Health and Safety Amendments Act; Fish and Wildlife Coordination Act; National Historic Preservation Act; Endangered Species Act; the Clear Water Act; and the Resource Conservation and Recovery Act. (DMC)

  2. Health and social care regulation in Wales: an integrated system of political, corporate and professional governance for improving public health.

    PubMed

    Jewell, Tony; Wilkinson, Jane

    2008-11-01

    Wales is developing a unique integrated system of governance to improve public health, which is diverging from some recent developments in the rest of the UK but shares many common features. There is a focus on strengthening collaborative working and co-ordination between bodies inspecting, regulating and auditing health and social care. Systems are being developed that are proportionate to the level of risk, eliminate unnecessary burdens of external review and support the improvement of services for patients, service users and carers. This is consistent with the Assembly Government's aim to improve the way that public services are delivered in Wales, including strengthening input from the public in the planning, delivery and reporting of regulation and inspection work. The test in the future will be how far we can demonstrate quantitatively and qualitatively the added value from our uniquely Welsh approach, built as it is on devolution and the aspirations for small-country governance. PMID:19058471

  3. 36 CFR 251.15 - Conditions, rules and regulations to govern exercise of mineral rights reserved in conveyances to...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 2 2013-07-01 2013-07-01 false Conditions, rules and regulations to govern exercise of mineral rights reserved in conveyances to the United States. 251.15 Section 251.15 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE LAND USES Miscellaneous Land Uses Natural Resources Control...

  4. 36 CFR 251.15 - Conditions, rules and regulations to govern exercise of mineral rights reserved in conveyances to...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... regulations to govern exercise of mineral rights reserved in conveyances to the United States. 251.15 Section... of mineral rights reserved in conveyances to the United States. (a) Except as otherwise provided in... permit. (4) Timber and/or young growth cut or destroyed in connection with exercise of the reserved...

  5. 7 CFR 301.55-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... DOMESTIC QUARANTINE NOTICES South American Cactus Moth § 301.55-4 Conditions governing the interstate... woven cloth) adequate to prevent access by South American cactus moths while moving through the... a certificate or limited permit if the regulated articles are cactus pads and fruits for...

  6. 7 CFR 301.55-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... DOMESTIC QUARANTINE NOTICES South American Cactus Moth § 301.55-4 Conditions governing the interstate... woven cloth) adequate to prevent access by South American cactus moths while moving through the... a certificate or limited permit if the regulated articles are cactus pads and fruits for...

  7. 7 CFR 301.55-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... DOMESTIC QUARANTINE NOTICES South American Cactus Moth § 301.55-4 Conditions governing the interstate... woven cloth) adequate to prevent access by South American cactus moths while moving through the... a certificate or limited permit if the regulated articles are cactus pads and fruits for...

  8. 7 CFR 301.55-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... DOMESTIC QUARANTINE NOTICES South American Cactus Moth § 301.55-4 Conditions governing the interstate... woven cloth) adequate to prevent access by South American cactus moths while moving through the... a certificate or limited permit if the regulated articles are cactus pads and fruits for...

  9. 7 CFR 301.55-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... DOMESTIC QUARANTINE NOTICES South American Cactus Moth § 301.55-4 Conditions governing the interstate... woven cloth) adequate to prevent access by South American cactus moths while moving through the... a certificate or limited permit if the regulated articles are cactus pads and fruits for...

  10. 7 CFR 301.45-4 - Conditions governing the interstate movement of regulated articles and outdoor household articles...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... SERVICE, DEPARTMENT OF AGRICULTURE DOMESTIC QUARANTINE NOTICES Gypsy Moth § 301.45-4 Conditions governing... gypsy moth life stages. (c) A regulated article originating in a generally infested area may be moved... adequate to prevent the dissemination of the gypsy moth, i.e., conditions of treatment,...

  11. 7 CFR 301.45-4 - Conditions governing the interstate movement of regulated articles and outdoor household articles...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... SERVICE, DEPARTMENT OF AGRICULTURE DOMESTIC QUARANTINE NOTICES Gypsy Moth § 301.45-4 Conditions governing... gypsy moth life stages. (c) A regulated article originating in a generally infested area may be moved... adequate to prevent the dissemination of the gypsy moth, i.e., conditions of treatment,...

  12. 7 CFR 301.45-4 - Conditions governing the interstate movement of regulated articles and outdoor household articles...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... SERVICE, DEPARTMENT OF AGRICULTURE DOMESTIC QUARANTINE NOTICES Gypsy Moth § 301.45-4 Conditions governing... gypsy moth life stages. (c) A regulated article originating in a generally infested area may be moved... adequate to prevent the dissemination of the gypsy moth, i.e., conditions of treatment,...

  13. 7 CFR 301.45-4 - Conditions governing the interstate movement of regulated articles and outdoor household articles...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... SERVICE, DEPARTMENT OF AGRICULTURE DOMESTIC QUARANTINE NOTICES Gypsy Moth § 301.45-4 Conditions governing... gypsy moth life stages. (c) A regulated article originating in a generally infested area may be moved... adequate to prevent the dissemination of the gypsy moth, i.e., conditions of treatment,...

  14. 7 CFR 301.45-4 - Conditions governing the interstate movement of regulated articles and outdoor household articles...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... SERVICE, DEPARTMENT OF AGRICULTURE DOMESTIC QUARANTINE NOTICES Gypsy Moth § 301.45-4 Conditions governing... gypsy moth life stages. (c) A regulated article originating in a generally infested area may be moved... adequate to prevent the dissemination of the gypsy moth, i.e., conditions of treatment,...

  15. 78 FR 67004 - Removal of References to Credit Ratings in Certain Regulations Governing the Federal Home Loan Banks

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-08

    ... Certain Regulations Governing the Federal Home Loan Banks, 78 FR 30784, 30786-87 (May 23, 2013... Proposed Rule, 78 FR 30784 (proposing amendments to 12 CFR part 1267, part 1269, and part 1270). In... Corporation, and the Federal Home Loan Banks, 76 FR 5292 (Jan. 31, 2011). \\10\\ See Proposed Rule, Federal...

  16. 36 CFR 251.15 - Conditions, rules and regulations to govern exercise of mineral rights reserved in conveyances to...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... regulations to govern exercise of mineral rights reserved in conveyances to the United States. 251.15 Section... of mineral rights reserved in conveyances to the United States. (a) Except as otherwise provided in... prospect for, mine and remove minerals, oil, gas, or other inorganic substances, said reservations shall...

  17. 7 CFR 301.48-4 - Conditions governing the interstate movement of regulated articles from quarantined States.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... DOMESTIC QUARANTINE NOTICES Japanese Beetle Quarantine and Regulations § 301.48-4 Conditions governing the... threat to spread the Japanese beetle because adult beetle populations are not present; or (b) The... be free of and safeguarded against Japanese beetle; or (c) The aircraft is loaded during the hours...

  18. 49 CFR 350.337 - How may State laws and regulations governing motor carriers, CMV drivers, and CMVs in interstate...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... regulations governing motor carriers, CMV drivers, and CMVs in interstate commerce differ from the FMCSRs and still be considered compatible? States are not required to adopt 49 CFR parts 398 and 399, subparts A... carriers, CMV drivers, and CMVs in interstate commerce differ from the FMCSRs and still be...

  19. 49 CFR 350.337 - How may State laws and regulations governing motor carriers, CMV drivers, and CMVs in interstate...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... carriers, CMV drivers, and CMVs in interstate commerce differ from the FMCSRs and still be considered... regulations governing motor carriers, CMV drivers, and CMVs in interstate commerce differ from the FMCSRs and still be considered compatible? States are not required to adopt 49 CFR parts 398 and 399, subparts...

  20. 7 CFR 301.52-3 - Conditions governing the interstate movement of regulated articles from quarantined States. 2

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... DOMESTIC QUARANTINE NOTICES Pink Bollworm Quarantine and Regulations § 301.52-3 Conditions governing the... present a hazard of the spread of the pink bollworm and the person in possession thereof has been so... articles has been notified by an inspector that a hazard of spread of the pink bollworm exists; or...

  1. 7 CFR 301.52-3 - Conditions governing the interstate movement of regulated articles from quarantined States. 2

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... DOMESTIC QUARANTINE NOTICES Pink Bollworm Quarantine and Regulations § 301.52-3 Conditions governing the... present a hazard of the spread of the pink bollworm and the person in possession thereof has been so... articles has been notified by an inspector that a hazard of spread of the pink bollworm exists; or...

  2. 7 CFR 301.52-3 - Conditions governing the interstate movement of regulated articles from quarantined States. 2

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... DOMESTIC QUARANTINE NOTICES Pink Bollworm Quarantine and Regulations § 301.52-3 Conditions governing the... present a hazard of the spread of the pink bollworm and the person in possession thereof has been so... articles has been notified by an inspector that a hazard of spread of the pink bollworm exists; or...

  3. 7 CFR 301.52-3 - Conditions governing the interstate movement of regulated articles from quarantined States. 2

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... DOMESTIC QUARANTINE NOTICES Pink Bollworm Quarantine and Regulations § 301.52-3 Conditions governing the... present a hazard of the spread of the pink bollworm and the person in possession thereof has been so... articles has been notified by an inspector that a hazard of spread of the pink bollworm exists; or...

  4. 7 CFR 301.52-3 - Conditions governing the interstate movement of regulated articles from quarantined States. 2

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... DOMESTIC QUARANTINE NOTICES Pink Bollworm Quarantine and Regulations § 301.52-3 Conditions governing the... present a hazard of the spread of the pink bollworm and the person in possession thereof has been so... articles has been notified by an inspector that a hazard of spread of the pink bollworm exists; or...

  5. 49 CFR 350.337 - How may State laws and regulations governing motor carriers, CMV drivers, and CMVs in interstate...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... regulations governing motor carriers, CMV drivers, and CMVs in interstate commerce differ from the FMCSRs and still be considered compatible? States are not required to adopt 49 CFR parts 398 and 399, subparts A... carriers, CMV drivers, and CMVs in interstate commerce differ from the FMCSRs and still be...

  6. 36 CFR 251.14 - Conditions, rules and regulations to govern exercise of timber rights reserved in conveyance to...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... locality for sales of similar National Forest timber and timber products. (4) Slash and debris resulting... with the protection and administration of the National Forest. (11) Operator shall take all reasonable... regulations to govern exercise of timber rights reserved in conveyance to the United States. 251.14...

  7. 36 CFR 251.14 - Conditions, rules and regulations to govern exercise of timber rights reserved in conveyance to...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... locality for sales of similar National Forest timber and timber products. (4) Slash and debris resulting... with the protection and administration of the National Forest. (11) Operator shall take all reasonable... regulations to govern exercise of timber rights reserved in conveyance to the United States. 251.14...

  8. 36 CFR 251.14 - Conditions, rules and regulations to govern exercise of timber rights reserved in conveyance to...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... locality for sales of similar National Forest timber and timber products. (4) Slash and debris resulting... with the protection and administration of the National Forest. (11) Operator shall take all reasonable... regulations to govern exercise of timber rights reserved in conveyance to the United States. 251.14...

  9. 7 CFR 301.48-4 - Conditions governing the interstate movement of regulated articles from quarantined States.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... DOMESTIC QUARANTINE NOTICES Japanese Beetle Quarantine and Regulations § 301.48-4 Conditions governing the... threat to spread the Japanese beetle because adult beetle populations are not present; or (b) The... be free of and safeguarded against Japanese beetle; or (c) The aircraft is loaded during the hours...

  10. 49 CFR 350.337 - How may State laws and regulations governing motor carriers, CMV drivers, and CMVs in interstate...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... regulations governing motor carriers, CMV drivers, and CMVs in interstate commerce differ from the FMCSRs and still be considered compatible? States are not required to adopt 49 CFR parts 398 and 399, subparts A... carriers, CMV drivers, and CMVs in interstate commerce differ from the FMCSRs and still be...

  11. 49 CFR 350.337 - How may State laws and regulations governing motor carriers, CMV drivers, and CMVs in interstate...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... regulations governing motor carriers, CMV drivers, and CMVs in interstate commerce differ from the FMCSRs and still be considered compatible? States are not required to adopt 49 CFR parts 398 and 399, subparts A... carriers, CMV drivers, and CMVs in interstate commerce differ from the FMCSRs and still be...

  12. 10 CFR Appendix A to Part 603 - Applicable Federal Statutes, Executive Orders, and Government-wide Regulations

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 745 and rules on animal acquisition, transport, care, handling and use in 9 CFR parts 1 through 4... Government-wide common rule that the DOE has codified at 10 CFR part 601. The “List of Certifications and... Act of 1964 (42 U.S.C. 2000d, et seq.) as implemented by DOE regulations at 10 CFR part 1040....

  13. 10 CFR Appendix A to Part 603 - Applicable Federal Statutes, Executive Orders, and Government-wide Regulations

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 745 and rules on animal acquisition, transport, care, handling and use in 9 CFR parts 1 through 4... Government-wide common rule that the DOE has codified at 10 CFR part 601. The “List of Certifications and... Act of 1964 (42 U.S.C. 2000d, et seq.) as implemented by DOE regulations at 10 CFR part 1040....

  14. Fifty Educational Markets: A Playbook of State Laws and Regulations Governing Private Schools. School Choice Issues in Depth

    ERIC Educational Resources Information Center

    Hammons, Christopher

    2008-01-01

    There is a widespread misperception that private schools avoid government oversight or are "unregulated." In fact, private schools are subject to a wide variety of laws and regulations that run the gamut from reasonable rules to ensure health and safety to unreasonable rules that interfere with school curricula, preventing schools from pursuing…

  15. Government regulation and public opposition create high additional costs for field trials with GM crops in Switzerland.

    PubMed

    Bernauer, Thomas; Tribaldos, Theresa; Luginbühl, Carolin; Winzeler, Michael

    2011-12-01

    Field trials with GM crops are not only plant science experiments. They are also social experiments concerning the implications of government imposed regulatory constraints and public opposition for scientific activity. We assess these implications by estimating additional costs due to government regulation and public opposition in a recent set of field trials in Switzerland. We find that for every Euro spent on research, an additional 78 cents were spent on security, an additional 31 cents on biosafety, and an additional 17 cents on government regulatory supervision. Hence the total additional spending due to government regulation and public opposition was around 1.26 Euros for every Euro spent on the research per se. These estimates are conservative; they do not include additional costs that are hard to monetize (e.g. stakeholder information and dialogue activities, involvement of various government agencies). We conclude that further field experiments with GM crops in Switzerland are unlikely unless protected sites are set up to reduce these additional costs. PMID:21279684

  16. 76 FR 21852 - Defense Federal Acquisition Regulation Supplement; Responsibility and Liability for Government...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-19

    ...; Responsibility and Liability for Government Property (DFARS Case 2010-D018) AGENCY: Defense Acquisition... other than submission of certified cost or pricing data. FAR 45.104, Responsibility and liability for... read as follows: 245.104 Responsibility and liability for Government property. (a) In addition to...

  17. 31 CFR 363.201 - What other regulations govern book-entry marketable book-entry Treasury bills, notes, and bonds?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., and bonds? (a) 31 CFR part 356 governs the sale and issue of marketable book-entry Treasury securities... commercial book-entry system. (b) 31 CFR part 357 governs holding marketable book-entry Treasury bills, notes... 31 Money and Finance:Treasury 2 2011-07-01 2011-07-01 false What other regulations govern...

  18. 31 CFR 363.201 - What other regulations govern book-entry marketable book-entry Treasury bills, notes, and bonds?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., and bonds? (a) 31 CFR part 356 governs the sale and issue of marketable book-entry Treasury securities... commercial book-entry system. (b) 31 CFR part 357 governs holding marketable book-entry Treasury bills, notes... 31 Money and Finance:Treasury 2 2012-07-01 2012-07-01 false What other regulations govern...

  19. 31 CFR 363.201 - What other regulations govern book-entry marketable book-entry Treasury bills, notes, and bonds?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ..., and bonds? (a) 31 CFR part 356 governs the sale and issue of marketable book-entry Treasury securities... commercial book-entry system. (b) 31 CFR part 357 governs holding marketable book-entry Treasury bills, notes... 31 Money and Finance:Treasury 2 2013-07-01 2013-07-01 false What other regulations govern...

  20. 31 CFR 363.201 - What other regulations govern book-entry marketable book-entry Treasury bills, notes, and bonds?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ..., and bonds? (a) 31 CFR part 356 governs the sale and issue of marketable book-entry Treasury securities... commercial book-entry system. (b) 31 CFR part 357 governs holding marketable book-entry Treasury bills, notes... 31 Money and Finance: Treasury 2 2014-07-01 2014-07-01 false What other regulations govern...

  1. 31 CFR 363.201 - What other regulations govern book-entry marketable book-entry Treasury bills, notes, and bonds?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., and bonds? (a) 31 CFR part 356 governs the sale and issue of marketable book-entry Treasury securities... commercial book-entry system. (b) 31 CFR part 357 governs holding marketable book-entry Treasury bills, notes... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false What other regulations govern...

  2. Encouraging Maternal Sacrifice: How Regulations Governing the Consumption of Pharmaceuticals During Pregnancy Prioritize Fetal Safety over Maternal Health and Autonomy.

    PubMed

    Donley, Greer

    Pregnant women are routinely faced with the stressful decision of whether to consume needed medications during their pregnancies. Because the risks associated with pharmaceutical drug consumption during pregnancy are largely unknown, pregnant women both inadvertently consume dangerous medications and avoid needed drugs. Both outcomes are harmful to pregnant women and their fetuses. This unparalleled lack of drug safety information is a result of ill-conceived, paternalistic regulations in two areas of the law: regulations governing ethical research in human subjects and regulations that dictate the required labels on drugs. The former categorizes pregnant women as "vulnerable" and thus precludes them from most medical research. The result is that ninety-one percent of drugs lack any reliable safety information for pregnant consumers. The latter currently requires all drug labels to encourage drug avoidance during pregnancy, despite ample evidence that avoiding needed medications can harm pregnant women. On June 30, 2015, new pregnancy labeling regulations took effect. Though these regulations make important improvements, they continue to treat pregnant women unlike any population, including other unique subpopulations, such as children. As a result, the new regulations do not fix the problem of over-warning pregnant women about the risks of drug consumption. This article questions the legitimacy of both regulations and suggests three reforms for how to improve access to vital safety information: (1) amend the regulations governing ethical research in human subjects to reclassify pregnant women as non-vulnerable adults; (2) create incentives to generate safety data in pregnant women by granting a period of market exclusivity for drug companies that invest in this research; and (3) make the FDA pregnancy labeling regulations consistent with the routine FDA practice of requiring the display of balanced, human data on risk. PMID:26793823

  3. 75 FR 22729 - Defense Federal Acquisition Regulation Supplement; Reporting of Government Property Lost, Stolen...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-30

    ... inventory adjustments of ``low risk'' consumable material such as common hardware, as agreed to by the...'' consumable material such as common hardware, as agreed to by the Contractor and the Government...

  4. Reflections on different governance styles in regulating science: a contribution to 'Responsible Research and Innovation'.

    PubMed

    Landeweerd, Laurens; Townend, David; Mesman, Jessica; Van Hoyweghen, Ine

    2015-01-01

    In European science and technology policy, various styles have been developed and institutionalised to govern the ethical challenges of science and technology innovations. In this paper, we give an account of the most dominant styles of the past 30 years, particularly in Europe, seeking to show their specific merits and problems. We focus on three styles of governance: a technocratic style, an applied ethics style, and a public participation style. We discuss their merits and deficits, and use this analysis to assess the potential of the recently established governance approach of 'Responsible Research and Innovation' (RRI). Based on this analysis, we reflect on the current shaping of RRI in terms of 'doing governance'. PMID:26260065

  5. Governing through Prevent? Regulation and Contested Practice in State–Muslim Engagement

    PubMed Central

    O’Toole, Therese; Meer, Nasar; DeHanas, Daniel Nilsson; Jones, Stephen H; Modood, Tariq

    2016-01-01

    In this article, we consider the implications of the ‘Prevent’ strand of the government’s counter-terrorism strategy for the UK state’s engagement with Muslims. We argue that the logics of Prevent have been highly problematic for state–Muslim engagement. Nevertheless, we suggest that the characterisation of state approaches to engaging Muslims as a form of discipline is incomplete without an analysis of: first, differences in practices, habits and perspectives across governance domains; second, variations in approach and implementation between levels of governance; and third, the agency of Muslims who engage with the state. Through this approach we show how attention to the situated practices of governance reveals the contested nature of governing through Prevent. PMID:26877558

  6. 76 FR 61597 - Grants and Cooperative Agreements to State and Local Governments: DOT Amendments on Regulations...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-05

    ... and Agreements With Institutions of Higher Education, Hospitals and Other Non-Profit Organizations... Agreements to State and Local Governments; Grants and Agreements with Institutions of Higher Education... uniform administrative requirements for grants and agreements with Institutions of Higher...

  7. 49 CFR 805.735-14 - Specific regulations for special Government employees.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...) Receipt of gifts, entertainment, and favors. (1) A special Government employee, while employed by the... with the Board, anything of value such as a gift, gratuity, loan, entertainment, or favor for...

  8. 76 FR 72914 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Government...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-28

    ... Defense Acquisition Regulations System Information Collection Requirement; Defense Federal Acquisition... Foreign Disclosure and Technical Information System,'' and is used when directed by the plant clearance... Regulations System, Department of Defense (DoD). ACTION: Notice and request for comments. SUMMARY:...

  9. 76 FR 5292 - Alternatives to Use of Credit Ratings in Regulations Governing the Federal National Mortgage...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-31

    ... references to credit ratings in their capital regulations and prudential standards. See 75 FR 49423 (Aug. 13, 2010), and 75 FR 52283 (Aug. 25, 2010). The specific FHFA regulations at issue are discussed more...

  10. 31 CFR 351.1 - What regulations govern Series EE savings bonds?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...) The regulations in 31 CFR part 353 apply to definitive (paper) Series EE savings bonds that have not been converted to book-entry bonds through New Treasury Direct. (b) The regulations in 31 CFR part 363... through New Treasury Direct. (c) The regulations in 31 CFR part 370 apply to transactions for the...

  11. 31 CFR 351.1 - What regulations govern Series EE savings bonds?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...) The regulations in 31 CFR part 353 apply to definitive (paper) Series EE savings bonds that have not been converted to book-entry bonds through New Treasury Direct. (b) The regulations in 31 CFR part 363... through New Treasury Direct. (c) The regulations in 31 CFR part 370 apply to transactions for the...

  12. 31 CFR 351.1 - What regulations govern Series EE savings bonds?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...) The regulations in 31 CFR part 353 apply to definitive (paper) Series EE savings bonds that have not been converted to book-entry bonds through New Treasury Direct. (b) The regulations in 31 CFR part 363... through New Treasury Direct. (c) The regulations in 31 CFR part 370 apply to transactions for the...

  13. 31 CFR 351.1 - What regulations govern Series EE savings bonds?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...) The regulations in 31 CFR part 353 apply to definitive (paper) Series EE savings bonds that have not been converted to book-entry bonds through New Treasury Direct. (b) The regulations in 31 CFR part 363... through New Treasury Direct. (c) The regulations in 31 CFR part 370 apply to transactions for the...

  14. 31 CFR 351.1 - What regulations govern Series EE savings bonds?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) The regulations in 31 CFR part 353 apply to definitive (paper) Series EE savings bonds that have not been converted to book-entry bonds through New Treasury Direct. (b) The regulations in 31 CFR part 363... through New Treasury Direct. (c) The regulations in 31 CFR part 370 apply to transactions for the...

  15. 77 FR 24611 - Removal of Regulations Requiring 3% Withholding by Government Entities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-25

    ... 9524, 76 FR 26583, 2011-23 IRB 843) (the May 2011 final regulations). Those regulations were issued to... in the Federal Register on May 9, 2011 (REG-151687-10, 76 FR 26678, 2011-23 IRB 867). A related... Internal Revenue Service 26 CFR Part 31 RIN 1545-BK83 Removal of Regulations Requiring 3% Withholding...

  16. 7 CFR 301.87-4 - Conditions governing the interstate movement of regulated articles from regulated areas in...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ..., DEPARTMENT OF AGRICULTURE DOMESTIC QUARANTINE NOTICES Sugarcane Diseases Quarantine and Regulations § 301.87... identity has been maintained, and it has not been used for the production of sugarcane while in...

  17. 7 CFR 301.87-4 - Conditions governing the interstate movement of regulated articles from regulated areas in...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ..., DEPARTMENT OF AGRICULTURE DOMESTIC QUARANTINE NOTICES Sugarcane Diseases Quarantine and Regulations § 301.87... identity has been maintained, and it has not been used for the production of sugarcane while in...

  18. 7 CFR 301.87-4 - Conditions governing the interstate movement of regulated articles from regulated areas in...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ..., DEPARTMENT OF AGRICULTURE DOMESTIC QUARANTINE NOTICES Sugarcane Diseases Quarantine and Regulations § 301.87... identity has been maintained, and it has not been used for the production of sugarcane while in...

  19. 7 CFR 301.87-4 - Conditions governing the interstate movement of regulated articles from regulated areas in...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ..., DEPARTMENT OF AGRICULTURE DOMESTIC QUARANTINE NOTICES Sugarcane Diseases Quarantine and Regulations § 301.87... identity has been maintained, and it has not been used for the production of sugarcane while in...

  20. 7 CFR 301.87-4 - Conditions governing the interstate movement of regulated articles from regulated areas in...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ..., DEPARTMENT OF AGRICULTURE DOMESTIC QUARANTINE NOTICES Sugarcane Diseases Quarantine and Regulations § 301.87... identity has been maintained, and it has not been used for the production of sugarcane while in...

  1. [Governance and regulation in health: challenges for health management in Greater Metropolitan São Paulo, Brazil].

    PubMed

    Ibanhes, Lauro Cesar; Heimann, Luiza Sterman; Junqueira, Virginia; Boaretto, Roberta Cristina; Pessoto, Umberto Catarino; Cortizo, Carlos Tato; Castro, Iracema Ester do Nascimento; Rocha, Jucilene Leite da; Kayano, Jorge; Luiz, Olinda do Carmo; Barboza, Renato; Telesi, Emilio

    2007-03-01

    This paper discusses the relationship between the public and private sectors in the Unified National Health System (SUS), based on research whose objective was to identify governance strategies and mechanisms for public/private relations in the health sector, considering the search for equity in Greater Metropolitan Sao Paulo, Brazil. Governance was used as an analytical category, with health system regulation as the issue. Municipal and State health secretaries, members of health councils, and SUS staff were interviewed, and the empirical material was classified as: (a) regulatory mechanisms and instruments; (b) power loci; and (c) actors' positions concerning the SUS and its relationship to the private sector. Mechanisms and instruments have been created and used in the municipalities for regulation of their own services. Regulatory measures for the complementary and supplementary healthcare sector are practically nonexistent. There are numerous institutional power loci, seen more as places for submitting demands than as forums for negotiation. Despite some progress, governance appears to be more of a formal issue. Discussion is needed on the relationship between the public and private sectors and its regulation by municipalities in order to improve the health system. PMID:17334572

  2. 43 CFR 3270.10 - What types of geothermal operations are governed by these utilization regulations?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... facilities; (3) Related utilization facility operations; (4) Actual and allocated well field production and injection; and (5) Related well field operations. (b) The utilization regulations in subparts 3270...

  3. 75 FR 80426 - Defense Federal Acquisition Regulation Supplement; Reporting of Government-Furnished Property

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-22

    ... defined in FAR part 45; (2) Property under any statutory leasing authority; (3) Property to which the... recognized unique identification equivalent. Unit of issue means the physical measurement of count or...) Property under any statutory leasing authority; (3) Property to which the Government has acquired a lien...

  4. 32 CFR 761.20 - Additional regulations governing persons and vessels in Naval Defensive Sea Areas.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... promulgated thereunder (7 FR 7307; 32 CFR 765.19(b)). (2) It shall be the duty of the master or officer in... in Executive Order 9275 of November 23, 1942 (7 FR 9767; 1943 Cum. Supp. p. 1227) to govern...

  5. 32 CFR 761.20 - Additional regulations governing persons and vessels in Naval Defensive Sea Areas.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... promulgated thereunder (7 FR 7307; 32 CFR 765.19(b)). (2) It shall be the duty of the master or officer in... in Executive Order 9275 of November 23, 1942 (7 FR 9767; 1943 Cum. Supp. p. 1227) to govern...

  6. 76 FR 6006 - Defense Federal Acquisition Regulation Supplement; Reporting of Government Property Lost, Stolen...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-02

    ... comments on the proposed rule, which was published at 75 FR 22729 on April 30, 2010. Comments were due June... consumable material such as common hardware, as agreed to by the contractor and the Government property... low- risk consumable material such as common hardware, as agreed to by the Contractor and...

  7. 76 FR 12666 - Defense Federal Acquisition Regulation Supplement; Reporting of Government-Furnished Property

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-08

    ....m. to 4 p.m. DST. DoD published a notice of the public meeting on March 1, 2011 (76 FR 11190). This..., 2010 (75 FR 80427). DoD published an extension of the public comment period on February 18, 2011 (75 FR... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF...

  8. 76 FR 21812 - Defense Federal Acquisition Regulation Supplement; Ownership or Control by a Foreign Government...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-19

    .... SUPPLEMENTARY INFORMATION: I. Background DoD published an interim rule in the Federal Register at 75 FR 35684 on... or controlled by a foreign government. DoD published an interim rule in the Federal Register at 75 FR... 209 and 252 published at 75 FR 35684 on June 23, 2010, is adopted as final without change....

  9. TEQSA and Risk-Based Regulation: Considerations for University Governing Bodies

    ERIC Educational Resources Information Center

    Baird, Jeanette

    2013-01-01

    The advent of a new national regulatory and quality assurance regime in Australia, through the Tertiary Education Quality and Standards Agency (TEQSA), presents additional requirements to university governing bodies, for compliance with standards and for risk management. This paper discusses TEQSA's approach and potential vulnerabilities for…

  10. Governing Education through Data in England: From Regulation to Self-Evaluation

    ERIC Educational Resources Information Center

    Ozga, Jenny

    2009-01-01

    This paper explores the relationship between changing forms of the governance of education and the growth and uses of data in the context of England--a context that can be described as the most "advanced" in Europe in terms of data production and use. The paper links the shifting relations between the central department of education (variously…

  11. 75 FR 25160 - Defense Federal Acquisition Regulation Supplement; Marking of Government-Furnished Property...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-07

    ... Supplement; Marking of Government-Furnished Property (DFARS Case 2008-D050) AGENCY: Defense Acquisition... throughout their lifecycle (in acquisition and logistics business processes and systems) in an integrated approach across the Department of Defense, Federal and state agencies, non-governmental organizations,...

  12. 78 FR 42921 - Amendments to Regulations Governing Ocean Transportation Intermediary Licensing and Financial...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-18

    ... Licensing and Financial Responsibility Requirements, and General Duties AGENCY: Federal Maritime Commission... Commission proposes to amend its rules governing the licensing, financial responsibility requirements and... Rulemaking, published on May 31, 2013 (78 FR 32946), are due on or before August 30, 2013. ADDRESSES:...

  13. Roll-Out Neoliberalism and Hybrid Practices of Regulation in Australian Agri-Environmental Governance

    ERIC Educational Resources Information Center

    Lockie, Stewart; Higgins, Vaughan

    2007-01-01

    In the last 15 years, agri-environmental programmes in Australia have been underpinned by a neoliberal regime of governing which seeks to foster participation and "bottom-up" change at the regional level at the same time as encouraging farmers to become entrepreneurial and improve their productivity and environmental performance without government…

  14. 78 FR 32945 - Amendments to Regulations Governing Ocean Transportation Intermediary Licensing and Financial...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-31

    ...The Federal Maritime Commission proposes to amend its rules governing the licensing, financial responsibility requirements and duties of Ocean Transportation Intermediaries. The proposed rule is intended to adapt to changing industry conditions, improve regulatory effectiveness, improve transparency, streamline processes and reduce regulatory...

  15. 75 FR 75444 - Defense Federal Acquisition Regulation Supplement; Government Property (DFARS Case 2009-D008)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-03

    ... consistency with FAR changes published at 72 FR 27364 on May 15, 2007, that address management of Government property in the possession of contractors, as well as the related ] DFARS changes published at 74 FR 37645..., updated, and relocated from 245.608-1 and 245.608- 2. 245.602-70 Added subsection to address...

  16. 75 FR 52459 - Regulations Governing Agencies for Issue of United States Savings Bonds; Offering of United...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-26

    ... discontinuing the issuance of definitive (paper) savings bonds through payroll savings plans. DATES: Effective... through payroll savings plans. Treasury will eliminate the option to purchase paper savings bonds through payroll deductions for United States government employees on October 1, 2010, and for all other...

  17. God and Government at Yale: The Limits of Federal Regulation of Higher Education

    ERIC Educational Resources Information Center

    O'Neil, Robert M.

    1975-01-01

    A preliminary overview of the constitutional issues in the relationship between higher education and federal regulation or control is offered. Reference is made to the Dartmouth College case and the views of Yale President Kingman Brewster, and to implications of Title IX regulations. (LBH)

  18. 31 CFR 359.1 - What regulations govern Series I savings bonds?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) The regulations in 31 CFR part 360 apply to definitive (paper) Series I savings bonds that have not been converted to book-entry bonds through New Treasury Direct. (b) The regulations in 31 CFR part 363... Treasury Direct; and (2) definitive Series I savings bonds that have been converted to book-entry...

  19. 31 CFR 359.1 - What regulations govern Series I savings bonds?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...) The regulations in 31 CFR part 360 apply to definitive (paper) Series I savings bonds that have not been converted to book-entry bonds through New Treasury Direct. (b) The regulations in 31 CFR part 363... Treasury Direct; and (2) definitive Series I savings bonds that have been converted to book-entry...

  20. 31 CFR 359.1 - What regulations govern Series I savings bonds?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...) The regulations in 31 CFR part 360 apply to definitive (paper) Series I savings bonds that have not been converted to book-entry bonds through New Treasury Direct. (b) The regulations in 31 CFR part 363... Treasury Direct; and (2) definitive Series I savings bonds that have been converted to book-entry...

  1. 31 CFR 359.1 - What regulations govern Series I savings bonds?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...) The regulations in 31 CFR part 360 apply to definitive (paper) Series I savings bonds that have not been converted to book-entry bonds through New Treasury Direct. (b) The regulations in 31 CFR part 363... Treasury Direct; and (2) Definitive Series I savings bonds that have been converted to book-entry...

  2. 31 CFR 359.1 - What regulations govern Series I savings bonds?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...) The regulations in 31 CFR part 360 apply to definitive (paper) Series I savings bonds that have not been converted to book-entry bonds through New Treasury Direct. (b) The regulations in 31 CFR part 363... Treasury Direct; and (2) definitive Series I savings bonds that have been converted to book-entry...

  3. 76 FR 17762 - Regulations Governing the Performance of Actuarial Services Under the Employee Retirement Income...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-31

    ...This document contains final regulations under section 3042 of the Employee Retirement Income Security Act of 1974 (ERISA) relating to the enrollment of actuaries. These regulations update the eligibility requirements for performing actuarial services for ERISA-covered employee pension benefit plans, including the continuing professional education requirements, and the standards for performing......

  4. 78 FR 52851 - Revisions to Procedural Regulations Governing Transportation by Intrastate Pipelines; Correction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-27

    ... was published in the Federal Register on Tuesday, July 30, ] 2013 (78 FR 45850). The regulations... of Energy Market Regulation, Federal Energy Regulatory Commission, 888 First Street NE., Washington... ``total Annual Burden Hours'' column is changed from ``854'' to ``852''. Accordingly, in rule FR Doc....

  5. Some comments on the new regulations governing ethics committees in Italy.

    PubMed

    Petrini, Carlo

    2014-01-01

    Italy has recently introduced regulations that profoundly change the arrangement of ethics committees. Specifically, their numbers have been reduced from more than 200 to a few dozen.The decree defining the criteria for their composition and functioning includes regulations intended to improve efficiency and efficacy. The present article provides a brief overview of the new provisions and identifies some critical aspects. PMID:24968915

  6. 77 FR 22278 - Eagle Permits; Revisions to Regulations Governing Take Necessary To Protect Interests in...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-13

    ... eagles (74 FR 46836). Those regulations at 50 CFR 22.26 provide for permits to take bald eagles and... revisions to regulations under the Bald and Golden Eagle Protection Act for permits to take eagles where the...). Background The Bald and Golden Eagle Protection Act (16 U.S.C. 668-668d) (Eagle Act) prohibits take of...

  7. Regulations governing the issuance of certificates of airworthiness of aircraft in France

    NASA Technical Reports Server (NTRS)

    1923-01-01

    These regulations, approved by the Under Secretary of State for Aeronautics, in a ministerial decree 1124/2a, Feb. 19, 1923, cancels the regulations of Aug. 31, 1920, and supplements the decree of Aug. 14, 1920, fixing the conditions under which certificates of airworthiness may be issued,in conformity with Article 5 of said decree.

  8. 76 FR 32285 - Regulations Governing Practice Before the Internal Revenue Service

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-03

    ... periodically. The regulations were amended most recently on September 26, 2007 (TD 9359, 72 FR 54540), to...-138637-07) in the Federal Register (72 FR 54621) proposing to conform the professional standards under... Department published final regulations (TD 9436) in the Federal Register (73 FR 78430)...

  9. 76 FR 6311 - Regulations Affecting Publication of the United States Government Manual

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-04

    ... distributed to the general public and to officials of the Federal government in a print edition. 75 FR 33734.... 1506; sec. 6, E.O. 10530, 19 FR 2709; 3 CFR, 1954-1958 Comp., p. 189. ] Sec. 9.1 Publication required....C. 1506; sec. 6, E.O. 10530, 19 FR 2709, 3 CFR, 1954-1958 Comp., p. 189. 0 3. Revise Sec. 11.4...

  10. Structure of a Holliday junction complex reveals mechanisms governing a highly regulated DNA transaction

    PubMed Central

    Laxmikanthan, Gurunathan; Xu, Chen; Brilot, Axel F; Warren, David; Steele, Lindsay; Seah, Nicole; Tong, Wenjun; Grigorieff, Nikolaus; Landy, Arthur; Van Duyne, Gregory D

    2016-01-01

    The molecular machinery responsible for DNA expression, recombination, and compaction has been difficult to visualize as functionally complete entities due to their combinatorial and structural complexity. We report here the structure of the intact functional assembly responsible for regulating and executing a site-specific DNA recombination reaction. The assembly is a 240-bp Holliday junction (HJ) bound specifically by 11 protein subunits. This higher-order complex is a key intermediate in the tightly regulated pathway for the excision of bacteriophage λ viral DNA out of the E. coli host chromosome, an extensively studied paradigmatic model system for the regulated rearrangement of DNA. Our results provide a structural basis for pre-existing data describing the excisive and integrative recombination pathways, and they help explain their regulation. DOI: http://dx.doi.org/10.7554/eLife.14313.001 PMID:27223329

  11. Structure of a Holliday junction complex reveals mechanisms governing a highly regulated DNA transaction.

    PubMed

    Laxmikanthan, Gurunathan; Xu, Chen; Brilot, Axel F; Warren, David; Steele, Lindsay; Seah, Nicole; Tong, Wenjun; Grigorieff, Nikolaus; Landy, Arthur; Van Duyne, Gregory D

    2016-01-01

    The molecular machinery responsible for DNA expression, recombination, and compaction has been difficult to visualize as functionally complete entities due to their combinatorial and structural complexity. We report here the structure of the intact functional assembly responsible for regulating and executing a site-specific DNA recombination reaction. The assembly is a 240-bp Holliday junction (HJ) bound specifically by 11 protein subunits. This higher-order complex is a key intermediate in the tightly regulated pathway for the excision of bacteriophage λ viral DNA out of the E. coli host chromosome, an extensively studied paradigmatic model system for the regulated rearrangement of DNA. Our results provide a structural basis for pre-existing data describing the excisive and integrative recombination pathways, and they help explain their regulation. PMID:27223329

  12. 7 CFR 999.1 - Regulation governing the importation of dates.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Section 999.1 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE SPECIALTY... includes dates coated with a substance materially altering their color. (5) Dates prepared or...

  13. Codes and regulations governing handling, storage, use and release of toxic gases

    NASA Astrophysics Data System (ADS)

    Bolmen, Richard A.

    1988-07-01

    To control the hazards associated with the handling, storage, use and release of toxic gases in the manufacturing process, a number of codes and regulations have been promulgated. At the forefront of these regulations are the Uniform Fire Code (UFC), Article 51, ``Semiconductor Fabrication Facilities Using Hazardous Production Materials,'' 1985 Edition; UFC Article 80, ``Hazardous Materials,'' 1987 Revision; and the Toxic Gas Model Ordinance, California Assembly Bill 1021. Article 51 of the UFC is specific for semiconductor wafer fabrication facilities and regulates the storage, handling and use of hazardous production materials. Article 80 of the UFC has a much broader scope and incorporates requirements for prevention, control and mitigation of dangerous conditions related to hazardous materials. As it applies to toxic gases, Article 80 incorporates Article 51 requirements and in addition requires treatment systems to reduce discharge concentrations and mitigate unauthorized releases of toxic gases. The Toxic Gas Model Ordinance is specific to toxic gases and regulates storage, handling and use of toxic gases at new and existing facilities incorporating monitoring and treatment systems should an unauthorized release occur. This paper will focus on these regulations as they apply to toxic gases used by the semiconductor and photovoltaics industries.

  14. VEGF-A regulated by progesterone governs uterine angiogenesis and vascular remodelling during pregnancy

    PubMed Central

    Kim, Minah; Park, Hyeung Ju; Seol, Jae Won; Jang, Jeon Yeob; Cho, Young-Suk; Kim, Kyu Rae; Choi, Youngsok; Lydon, John P; DeMayo, Francesco J; Shibuya, Masabumi; Ferrara, Napoleone; Sung, Hoon-Ki; Nagy, Andras; Alitalo, Kari; Koh, Gou Young

    2013-01-01

    The features and regulation of uterine angiogenesis and vascular remodelling during pregnancy are poorly defined. Here we show that dynamic and variable decidual angiogenesis (sprouting, intussusception and networking), and active vigorous vascular remodelling such as enlargement and elongation of ‘vascular sinus folding’ (VSF) and mural cell drop-out occur distinctly in a spatiotemporal manner in the rapidly growing mouse uterus during early pregnancy — just after implantation but before placentation. Decidual angiogenesis is mainly regulated through VEGF-A secreted from the progesterone receptor (PR)-expressing decidual stromal cells which are largely distributed in the anti-mesometrial region (AMR). In comparison, P4-PR-regulated VEGF-A-VEGFR2 signalling, ligand-independent VEGFR3 signalling and uterine natural killer (uNK) cells positively and coordinately regulate enlargement and elongation of VSF. During the postpartum period, Tie2 signalling could be involved in vascular maturation at the endometrium in a ligand-independent manner, with marked reduction of VEGF-A, VEGFR2 and PR expressions. Overall, we show that two key vascular growth factor receptors — VEGFR2 and Tie2 — strikingly but differentially regulate decidual angiogenesis and vascular remodelling in rapidly growing and regressing uteri in an organotypic manner. PMID:23853117

  15. 75 FR 1525 - Walnuts Grown in California; Changes to Regulations Governing Voting Procedures

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-12

    ... the order (73 FR 11328, March 3, 2008). Prior to the amendment, the Board had the authority to vote by... published in the Federal Register on October 9, 2009 (74 FR 52154). Copies of the proposed rule were also... Board discussed the need to change the order's administrative regulations to include the use of...

  16. 77 FR 22267 - Eagle Permits; Changes in the Regulations Governing Eagle Permitting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-13

    ... for nonpurposeful take of eagles (74 FR 46836). Those regulations at 50 CFR 22.26 provide for permits... permits, see 74 FR 46841-46843. We can issue programmatic permits for disturbance as well as take... Interests in Particular Localities; Final Rules, (74 FR 46836- 46852, September 11, 2009). Monitoring...

  17. 77 FR 27174 - Eagle Permits; Changes in the Regulations Governing Eagle Permitting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-09

    ... published at 77 FR 22267, April 13, 2012, must be submitted via http://www.regulations.gov by 11:59 p.m... associated with, but not the purpose of, an activity (see 77 FR 22267, April 13, 2012). We proposed to extend... Bald and Golden Eagle Protection Act (16 U.S.C. 668-668d) to Federal, State, tribal, or...

  18. 17 CFR 230.161 - Amendments to rules and regulations governing exemptions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... securities under section 3(b) of the Act, as in effect at the time the securities are first bona fide offered... notwithstanding the subsequent amendment of such rules and regulations. This section shall not apply, however, to... amendment, nor shall it apply to any offering after January 1, 1959, of securities by an issuer...

  19. 17 CFR 230.161 - Amendments to rules and regulations governing exemptions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... securities under section 3(b) of the Act, as in effect at the time the securities are first bona fide offered... notwithstanding the subsequent amendment of such rules and regulations. This section shall not apply, however, to... amendment, nor shall it apply to any offering after January 1, 1959, of securities by an issuer...

  20. 17 CFR 230.161 - Amendments to rules and regulations governing exemptions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... securities under section 3(b) of the Act, as in effect at the time the securities are first bona fide offered... notwithstanding the subsequent amendment of such rules and regulations. This section shall not apply, however, to... amendment, nor shall it apply to any offering after January 1, 1959, of securities by an issuer...

  1. 17 CFR 230.161 - Amendments to rules and regulations governing exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... securities under section 3(b) of the Act, as in effect at the time the securities are first bona fide offered... notwithstanding the subsequent amendment of such rules and regulations. This section shall not apply, however, to... amendment, nor shall it apply to any offering after January 1, 1959, of securities by an issuer...

  2. 17 CFR 230.161 - Amendments to rules and regulations governing exemptions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... securities under section 3(b) of the Act, as in effect at the time the securities are first bona fide offered... notwithstanding the subsequent amendment of such rules and regulations. This section shall not apply, however, to... amendment, nor shall it apply to any offering after January 1, 1959, of securities by an issuer...

  3. 75 FR 2126 - Regulations Governing the Conduct of Open Seasons for Alaska Natural Gas Transportation Projects...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-14

    ... Gas Transportation Projects; Notice of Alaska Natural Gas Transportation Projects Open Season Pre... season for an Alaska Natural Gas Transportation Project. The Workshop is being hosted by the Alaska... docket, FERC enacted regulations under the Alaska Natural Gas Pipeline Act which established...

  4. 78 FR 33994 - Defense Federal Acquisition Regulation Supplement; Government Support Contractor Access to...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-06

    ... May 22, 2013 (78 FR 30233) in the amendatory language, correct the following: 252.212-7001 0 1. On...; correction. SUMMARY: This document corrects the amendatory language to a final rule published in the Federal Register on May 22, 2013, 78 FR 30233, regarding the Defense Federal Acquisition Regulation...

  5. 76 FR 29665 - Migratory Bird Permits; Changes in the Regulations Governing Raptor Propagation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-23

    ... propagation of raptors in the United States (70 FR 60052). We proposed to reorganize the current regulations... Propagation'' (71 FR 35599). We solicited comments on the draft environmental assessment until September 19... until November 21, 2006 (71 FR 54794). After consideration of all the comments received, we published...

  6. TORC1 Signaling Is Governed by Two Negative Regulators in Fission Yeast

    PubMed Central

    Ma, Ning; Liu, Qingbin; Zhang, Lili; Henske, Elizabeth P.; Ma, Yan

    2013-01-01

    The target of rapamycin (TOR) is a highly conserved protein kinase that regulates cell growth and metabolism. Here we performed a genome-wide screen to identify negative regulators of TOR complex 1 (TORC1) in Schizosaccharomyces pombe by isolating mutants that phenocopy Δtsc2, in which TORC1 signaling is known to be up-regulated. We discovered that Δnpr2 displayed similar phenotypes to Δtsc2 in terms of amino acid uptake defects and mislocalization of the Cat1 permease. However, Δnpr2 and Δtsc2 clearly showed different phenotypes in terms of rapamycin supersensitivity and Isp5 transcription upon various treatments. Furthermore, we showed that Tor2 controls amino acid homeostasis at the transcriptional and post-transcriptional levels. Our data reveal that both Npr2 and Tsc2 negatively regulate TORC1 signaling, and Npr2, but not Tsc2, may be involved in the feedback loop of a nutrient-sensing pathway. PMID:23934889

  7. 75 FR 51713 - Regulations Governing Practice Before the Internal Revenue Service

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-23

    ..., 2007 (72 FR 54540), to modify various provisions relating to the general standards of practice. For... issued a notice of proposed rulemaking (REG-138637-07) in the Federal Register (72 FR 54621) proposing to... IRS and the Treasury Department published final regulations (TD 9436) in the Federal Register (73...

  8. 77 FR 57055 - Regulations Governing Practice Before the Internal Revenue Service

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-17

    ... tax shelter offerings in accordance with American Bar Association Formal Opinion 346 (49 FR 6719). The.... See 66 FR 3276. The 2001 notice of proposed rulemaking addressed both general matters pertaining to..., Treasury and the IRS published in the Federal Register (68 FR 75186) (the 2003 proposed regulations)...

  9. Older smokers could be the strongest supporters for U.S. government regulation of tobacco: a focus group study

    PubMed Central

    2013-01-01

    Background Targeting of marginalized groups with aggressive tobacco marketing has been identified as exacerbating health disparities. However, interpretation of such targeting by groups varies, from surprise and outrage to regarding such marketing as evidence of social legitimacy. We sought to learn how an often-overlooked marginalized group, older adults, would respond to industry documents offering evidence of tobacco company target marketing. Methods We conducted 10 focus groups in California cities with older (≥50 years) smokers and former smokers. A set of previously-undisclosed tobacco industry documents related to target marketing was shown to the group in sequence. Audiotaped discussions were transcribed and data analyzed using qualitative approaches. Results Responses to evidence of tobacco industry targeting varied, with some regarding it as exploitive and others as normal business practice. However, in most groups, discussions turned to government’s failure to protect the public—even though government action /inaction was not prompted nor addressed in the discussion documents. Conclusion Given the Food and Drug Administration’s new authority to regulate tobacco products, these findings suggest that some of the tobacco industry’s “best customers” (older, established smokers and ex-smokers) may be strong supporters of government regulation of tobacco. PMID:23958397

  10. Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function.

    PubMed

    Arda, H Efsun; Li, Lingyu; Tsai, Jennifer; Torre, Eduardo A; Rosli, Yenny; Peiris, Heshan; Spitale, Robert C; Dai, Chunhua; Gu, Xueying; Qu, Kun; Wang, Pei; Wang, Jing; Grompe, Markus; Scharfmann, Raphael; Snyder, Michael S; Bottino, Rita; Powers, Alvin C; Chang, Howard Y; Kim, Seung K

    2016-05-10

    Intensive efforts are focused on identifying regulators of human pancreatic islet cell growth and maturation to accelerate development of therapies for diabetes. After birth, islet cell growth and function are dynamically regulated; however, establishing these age-dependent changes in humans has been challenging. Here, we describe a multimodal strategy for isolating pancreatic endocrine and exocrine cells from children and adults to identify age-dependent gene expression and chromatin changes on a genomic scale. These profiles revealed distinct proliferative and functional states of islet α cells or β cells and histone modifications underlying age-dependent gene expression changes. Expression of SIX2 and SIX3, transcription factors without prior known functions in the pancreas and linked to fasting hyperglycemia risk, increased with age specifically in human islet β cells. SIX2 and SIX3 were sufficient to enhance insulin content or secretion in immature β cells. Our work provides a unique resource to study human-specific regulators of islet cell maturation and function. PMID:27133132

  11. Identification of Nuclear Protein Targets for Six Leukemogenic Tyrosine Kinases Governed by Post-Translational Regulation

    PubMed Central

    Pierce, Andrew; Williamson, Andrew; Jaworska, Ewa; Griffiths, John R.; Taylor, Sam; Walker, Michael; O’Dea, Mark Aspinall; Spooncer, Elaine; Unwin, Richard D.; Poolman, Toryn; Ray, David; Whetton, Anthony D.

    2012-01-01

    Mutated tyrosine kinases are associated with a number of different haematological malignancies including myeloproliferative disorders, lymphoma and acute myeloid leukaemia. The potential commonalities in the action of six of these leukemogenic proteins on nuclear proteins were investigated using systematic proteomic analysis. The effects on over 3600 nuclear proteins and 1500 phosphopeptide sites were relatively quantified in seven isogenic cell lines. The effects of the kinases were diverse although some commonalities were found. Comparison of the nuclear proteomic data with transcriptome data and cytoplasmic proteomic data indicated that the major changes are due to post-translational mechanisms rather than changes in mRNA or protein distribution. Analysis of the promoter regions of genes whose protein levels changed in response to the kinases showed the most common binding site found was that for NFκB whilst other sites such as those for the glucocorticoid receptor were also found. Glucocorticoid receptor levels and phosphorylation were decreased by all 6 PTKs. Whilst Glucocorticoid receptor action can potentiate NFκB action those proteins where genes have NFκB binding sites were in often regulated post-translationally. However all 6 PTKs showed evidence of NFkB pathway modulation via activation via altered IkB and NFKB levels. Validation of a common change was also undertaken with PMS2, a DNA mismatch repair protein. PMS2 nuclear levels were decreased in response to the expression of all 6 kinases, with no concomitant change in mRNA level or cytosolic protein level. Response to thioguanine, that requires the mismatch repair pathway, was modulated by all 6 oncogenic kinases. In summary common targets for 6 oncogenic PTKs have been found that are regulated by post-translational mechanisms. They represent potential new avenues for therapies but also demonstrate the post-translational regulation is a key target of leukaemogenic kinases. PMID:22745689

  12. Neuroendocrine circuits governing energy balance and stress regulation: functional overlap and therapeutic implications

    PubMed Central

    Ulrich-Lai, Yvonne M.; Ryan, Karen K.

    2014-01-01

    Significant co-morbidities between obesity-related metabolic disease and stress-related psychological disorders suggest important functional interactions between energy balance and brain stress integration. Largely overlapping neural circuits control these systems, and this anatomical arrangement optimizes opportunities for mutual influence. Here we first review the current literature identifying effects of metabolic neuroendocrine signals on stress regulation, and vice versa. Next, the contributions of reward driven food intake to these metabolic and stress interactions are discussed. Lastly, we consider the inter-relationships among metabolism, stress and reward in light of their important implications in the development of therapies for metabolism- or stress-related disease. PMID:24630812

  13. Protein kinase G-regulated production of H2S governs oxygen sensing.

    PubMed

    Yuan, Guoxiang; Vasavda, Chirag; Peng, Ying-Jie; Makarenko, Vladislav V; Raghuraman, Gayatri; Nanduri, Jayasri; Gadalla, Moataz M; Semenza, Gregg L; Kumar, Ganesh K; Snyder, Solomon H; Prabhakar, Nanduri R

    2015-04-21

    Reflexes initiated by the carotid body, the principal O2-sensing organ, are critical for maintaining cardiorespiratory homeostasis during hypoxia. O2 sensing by the carotid body requires carbon monoxide (CO) generation by heme oxygenase-2 (HO-2) and hydrogen sulfide (H2S) synthesis by cystathionine-γ-lyase (CSE). We report that O2 stimulated the generation of CO, but not that of H2S, and required two cysteine residues in the heme regulatory motif (Cys(265) and Cys(282)) of HO-2. CO stimulated protein kinase G (PKG)-dependent phosphorylation of Ser(377) of CSE, inhibiting the production of H2S. Hypoxia decreased the inhibition of CSE by reducing CO generation resulting in increased H2S, which stimulated carotid body neural activity. In carotid bodies from mice lacking HO-2, compensatory increased abundance of nNOS (neuronal nitric oxide synthase) mediated O2 sensing through PKG-dependent regulation of H2S by nitric oxide. These results provide a mechanism for how three gases work in concert in the carotid body to regulate breathing. PMID:25900831

  14. CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice

    PubMed Central

    Shimokawa, Noriaki; Haglund, Kaisa; Hölter, Sabine M; Grabbe, Caroline; Kirkin, Vladimir; Koibuchi, Noriyuki; Schultz, Christian; Rozman, Jan; Hoeller, Daniela; Qiu, Chun-Hong; Londoño, Marina B; Ikezawa, Jun; Jedlicka, Peter; Stein, Birgit; Schwarzacher, Stephan W; Wolfer, David P; Ehrhardt, Nicole; Heuchel, Rainer; Nezis, Ioannis; Brech, Andreas; Schmidt, Mirko H H; Fuchs, Helmut; Gailus-Durner, Valerie; Klingenspor, Martin; Bogler, Oliver; Wurst, Wolfgang; Deller, Thomas; de Angelis, Martin Hrabé; Dikic, Ivan

    2010-01-01

    Despite extensive investigations of Cbl-interacting protein of 85 kDa (CIN85) in receptor trafficking and cytoskeletal dynamics, little is known about its functions in vivo. Here, we report the study of a mouse deficient of the two CIN85 isoforms expressed in the central nervous system, exposing a function of CIN85 in dopamine receptor endocytosis. Mice lacking CIN85 exon 2 (CIN85Δex2) show hyperactivity phenotypes, characterized by increased physical activity and exploratory behaviour. Interestingly, CIN85Δex2 animals display abnormally high levels of dopamine and D2 dopamine receptors (D2DRs) in the striatum, an important centre for the coordination of animal behaviour. Importantly, CIN85 localizes to the post-synaptic compartment of striatal neurons in which it co-clusters with D2DRs. Moreover, it interacts with endocytic regulators such as dynamin and endophilins in the striatum. Absence of striatal CIN85 causes insufficient complex formation of endophilins with D2DRs in the striatum and ultimately decreased D2DR endocytosis in striatal neurons in response to dopamine stimulation. These findings indicate an important function of CIN85 in the regulation of dopamine receptor functions and provide a molecular explanation for the hyperactive behaviour of CIN85Δex2 mice. PMID:20551902

  15. Pericytes Regulate Vascular Basement Membrane Remodeling and Govern Neutrophil Extravasation during Inflammation

    PubMed Central

    Wang, Shijun; Cao, Canhong; Chen, Zhongming; Bankaitis, Vytas; Tzima, Eleni; Sheibani, Nader; Burridge, Keith

    2012-01-01

    During inflammation polymorphonuclear neutrophils (PMNs) traverse venular walls, composed of the endothelium, pericyte sheath and vascular basement membrane. Compared to PMN transendothelial migration, little is known about how PMNs penetrate the latter barriers. Using mouse models and intravital microscopy, we show that migrating PMNs expand and use the low expression regions (LERs) of matrix proteins in the vascular basement membrane (BM) for their transmigration. Importantly, we demonstrate that this remodeling of LERs is accompanied by the opening of gaps between pericytes, a response that depends on PMN engagement with pericytes. Exploring how PMNs modulate pericyte behavior, we discovered that direct PMN-pericyte contacts induce relaxation rather than contraction of pericyte cytoskeletons, an unexpected response that is mediated by inhibition of the RhoA/ROCK signaling pathway in pericytes. Taking our in vitro results back into mouse models, we present evidence that pericyte relaxation contributes to the opening of the gaps between pericytes and to the enlargement of the LERs in the vascular BM, facilitating PMN extravasation. Our study demonstrates that pericytes can regulate PMN extravasation by controlling the size of pericyte gaps and thickness of LERs in venular walls. This raises the possibility that pericytes may be targeted in therapies aimed at regulating inflammation. PMID:23029055

  16. Regulations governing veterinary medicinal products containing genetically modified organisms in the European community.

    PubMed

    Moulin, G

    2005-04-01

    This paper describes particular aspects of the marketing of veterinary medicinal products (VMPs) that contain or consist of genetically modified micro-organisms (GMMs) or genetically modified organisms (GMOs). The regulatory requirements and the procedures applied in the European Union for each phase (pre-marketing, authorisation process, and post-authorisation labelling and monitoring) are explained. In most cases VMPs are subject to both pharmaceutical and GMO regulations. In the early stages of the process, before applications for marketing authorisation are submitted, the assessment of clinical trials and experiments in contained areas is principally the responsibility of national authorities. However, the marketing of all VMPs containing or consisting of GMOs must be authorised at European level, although the national authorities are informed and involved in the assessment process. PMID:16110880

  17. Risk for anxiety and implications for treatment: developmental, environmental, and genetic factors governing fear regulation

    PubMed Central

    Hartley, Catherine A.; Casey, BJ

    2013-01-01

    Anxiety disorders are the most common of the psychiatric disorders affecting as many as 10% of youth, with a peak during adolescence. A core component of these disorders is an unremitting fear in the absence of present threat. One of the most commonly used therapies to treat these disorders is exposure-based cognitive behavioral therapy that identifies the source of the fear and anxiety and then desensitizes the individual to it. This treatment builds on basic principles of fear extinction learning. A number of patients improve with this therapy, but 40–50% do not. This paper provides an overview of recent empirical studies employing both human imaging and cross-species behavioral genetics to examine how fear regulation varies across individuals and across development, especially during adolescence. These studies have important implications for understanding who may be at risk for anxiety disorders and for whom and when during development exposure-based therapies may be most effective. PMID:24147742

  18. mSin3A corepressor regulates diverse transcriptional networks governing normal and neoplastic growth and survival

    PubMed Central

    Dannenberg, Jan-Hermen; David, Gregory; Zhong, Sheng; van der Torre, Jaco; Wong, Wing H.; DePinho, Ronald A.

    2005-01-01

    involvement of mSin3A in the regulation of diverse pathways governing many aspects of normal and neoplastic growth and survival and provide an experimental framework for the analysis of essential genes with diverse biological functions. PMID:15998811

  19. Government Regulatory

    NASA Astrophysics Data System (ADS)

    Becker, Katie

    Government regulation of food products, food processing, and food preparation is imperative in bringing an unadulterated, nonmisleading, and safe food product to market and is relevant to all areas of food science, including engineering, processing, chemistry, and microbiology. The liability associated with providing consumers with an adulterated or substandard product cannot only tarnish a company's name and reputation, but also impose substantial financial repercussions on the company and those individuals who play an active role in the violation. In order for a company to fully comply with the relevant food laws (both federal and state), an intimate knowledge of food science is required. Individuals knowledgeable in food science play an integral role not only in implementing and counseling food companies/processors to ensure compliance with government regulations, but these individuals are also necessary to the state and federal governments that make and enforce the relevant laws and regulators.

  20. M.I.T. and the Federal Government. An Examination of the Effects of Government Regulation and Research Support on Selected Parts of M.I.T.

    ERIC Educational Resources Information Center

    Garvin, David

    A self-study was undertaken at the Massachusetts Institute of Technology (M.I.T.) to examine the impact of the federal government on it. M.I.T. is a large institution with an enrollment of 8,000, a faculty of 950, and a total teaching staff of 1,700. Of its operating expenses by far the largest source of funds in recent years has been sponsored…

  1. Renewing governance.

    PubMed

    Loos, Gregory P

    2003-01-01

    Globalization's profound influence on social and political institutions need not be negative. Critics of globalization have often referred to the "Impossible Trinity" because decision-making must 1. respect national sovereignty, 2. develop and implement firm regulation, and 3. allow capital markets to be as free as possible. To many, such goals are mutually exclusive because history conditions us to view policy-making and governance in traditional molds. Thus, transnational governance merely appears impossible because current forms of governance were not designed to provide it. The world needs new tools for governing, and its citizens must seize the opportunity to help develop them. The rise of a global society requires a greater level of generality and inclusion than is found in most policy bodies today. Politicians need to re-examine key assumptions about government. States must develop ways to discharge their regulatory responsibilities across borders and collaborate with neighboring jurisdictions, multilateral bodies, and business. Concepts such as multilateralism and tripartism show great promise. Governments must engage civil society in the spirit of shared responsibility and democratic decision-making. Such changes will result in a renewal of the state's purpose and better use of international resources and expertise in governance. PMID:17208717

  2. 7 CFR 301.86-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... if: (i) The regulated article is moved by the United States Department of Agriculture for experimental or scientific purposes; or (ii) The regulated article originates outside the quarantined area and... regulated articles from quarantined areas. (a) Any regulated article may be moved interstate from...

  3. 7 CFR 301.86-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... if: (i) The regulated article is moved by the United States Department of Agriculture for experimental or scientific purposes; or (ii) The regulated article originates outside the quarantined area and... regulated articles from quarantined areas. (a) Any regulated article may be moved interstate from...

  4. 7 CFR 301.50-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... regulated articles from quarantined areas. Any regulated article may be moved interstate from a quarantined... certificate or limited permit, if: (1)(i) The regulated article originates outside any quarantined area and is... temperature is below 10 °C (50 °F); or (ii) The regulated article originates outside any quarantined area...

  5. 7 CFR 301.50-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... regulated articles from quarantined areas. Any regulated article may be moved interstate from a quarantined... certificate or limited permit, if: (1)(i) The regulated article originates outside any quarantined area and is... temperature is below 10 °C (50 °F); or (ii) The regulated article originates outside any quarantined area...

  6. 7 CFR 301.51-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... limited permit if: (i) The regulated article is moved by the United States Department of Agriculture for experimental or scientific purposes; or (ii) The regulated article originates outside the quarantined area and... of regulated articles from quarantined areas. (a) Any regulated article may be moved interstate...

  7. 7 CFR 301.53-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... DOMESTIC QUARANTINE NOTICES Emerald Ash Borer § 301.53-4 Conditions governing the interstate movement of... infestation by emerald ash borer; and (iv) The article has not been combined or commingled with other...

  8. 7 CFR 301.53-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... DOMESTIC QUARANTINE NOTICES Emerald Ash Borer § 301.53-4 Conditions governing the interstate movement of... infestation by emerald ash borer; and (iv) The article has not been combined or commingled with other...

  9. 7 CFR 301.53-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... DOMESTIC QUARANTINE NOTICES Emerald Ash Borer § 301.53-4 Conditions governing the interstate movement of... infestation by emerald ash borer; and (iv) The article has not been combined or commingled with other...

  10. 7 CFR 301.53-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... DOMESTIC QUARANTINE NOTICES Emerald Ash Borer § 301.53-4 Conditions governing the interstate movement of... infestation by emerald ash borer; and (iv) The article has not been combined or commingled with other...

  11. 7 CFR 301.53-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... DOMESTIC QUARANTINE NOTICES Emerald Ash Borer § 301.53-4 Conditions governing the interstate movement of... infestation by emerald ash borer; and (iv) The article has not been combined or commingled with other...

  12. 7 CFR 301.92-4 - Conditions governing the interstate movement of regulated, restricted, and associated articles...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... regulated, restricted, and associated articles, and non-host nursery stock from quarantined and regulated... associated articles, and non-host nursery stock from quarantined and regulated areas. (a) Interstate movement... from nurseries in quarantined areas in accordance with paragraph (a) of this section. (2)...

  13. 7 CFR 301.92-4 - Conditions governing the interstate movement of regulated, restricted, and associated articles...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... regulated, restricted, and associated articles, and non-host nursery stock from quarantined and regulated... associated articles, and non-host nursery stock from quarantined and regulated areas. (a) Interstate movement... from nurseries in quarantined areas in accordance with paragraph (a) of this section. (2)...

  14. 7 CFR 301.92-4 - Conditions governing the interstate movement of regulated, restricted, and associated articles...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... regulated, restricted, and associated articles, and non-host nursery stock from quarantined and regulated... associated articles, and non-host nursery stock from quarantined and regulated areas. (a) Interstate movement... from nurseries in quarantined areas in accordance with paragraph (a) of this section. (2)...

  15. Self-Study Report by Roosevelt University on the Impact of Government Programs and the Cost of Compliance With Government Regulations for the Sloan Commission on Government and Higher Education.

    ERIC Educational Resources Information Center

    Perlman, Daniel H.

    A study was conducted to assess the impact of federal and state assistance, regulations, and requirements on Roosevelt University, Chicago. By means of a survey questionnaire and interviews, the University's vice presidents and other senior administrators were asked to estimate the amount of time and money spent by the school to comply with…

  16. 7 CFR 301.32-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... DOMESTIC QUARANTINE NOTICES Fruit Flies § 301.32-4 Conditions governing the interstate movement of... enclosed vehicle or is completely enclosed by a covering adequate to prevent access by fruit flies (such as... prevent the spread of fruit flies; and (4) With a tag or label bearing the number of the permit issued...

  17. 7 CFR 301.32-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... DOMESTIC QUARANTINE NOTICES Fruit Flies § 301.32-4 Conditions governing the interstate movement of... enclosed vehicle or is completely enclosed by a covering adequate to prevent access by fruit flies (such as... prevent the spread of fruit flies; and (4) With a tag or label bearing the number of the permit issued...

  18. 49 CFR 350.341 - What specific variances from the FMCSRs are allowed for State laws and regulations governing...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... mileage radius exemption contained in 49 CFR 395.1(e) from 100 to 150 miles. (e) Hours of service—State... intrastate commerce and not subject to Federal jurisdiction? 350.341 Section 350.341 Transportation Other... governing motor carriers, CMV drivers, and CMVs engaged in intrastate commerce and not subject to...

  19. Designing the Framework Conditions for Assuring Academic Standards: Lessons Learned about Professional, Market, and Government Regulation of Academic Quality

    ERIC Educational Resources Information Center

    Dill, David D.; Beerkens, Maarja

    2013-01-01

    The new demands of mass systems of higher education and the emerging environment of global academic competition are altering the traditional institutions for assuring academic standards in universities. As a consequence many nations are experimenting with new instruments for academic quality assurance. Contemporary government control of academic…

  20. 38 CFR Appendix B to Subpart E of... - List of Age Distinctions Contained in Statutes and Regulations Governing Federal Financial...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Section 90.31(f) of the governmentwide regulations (45 CFR part 90) requires each Federal agency to... Regulation Section and Age Distinction CFDA Veterans' Benefits Adjudication (38 CFR part 3) Section 3.57... death. . . .” Survivors' and Dependents' Educational Assistance Adjudication (38 CFR part 3) Section...

  1. 38 CFR Appendix B to Subpart E of... - List of Age Distinctions Contained in Statutes and Regulations Governing Federal Financial...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Section 90.31(f) of the governmentwide regulations (45 CFR part 90) requires each Federal agency to... Regulation Section and Age Distinction CFDA Veterans' Benefits Adjudication (38 CFR part 3) Section 3.57... death. . . .” Survivors' and Dependents' Educational Assistance Adjudication (38 CFR part 3) Section...

  2. 7 CFR 301.85-3 - Conditions governing the interstate movement of regulated articles from quarantined States. 2

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... applicable Federal domestic plant quarantines must also be met. (a) Any regulated articles except soil... Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... specifically authorized by the Deputy Administrator in emergency situations, soil samples for...

  3. 7 CFR 301.85-3 - Conditions governing the interstate movement of regulated articles from quarantined States. 2

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... applicable Federal domestic plant quarantines must also be met. (a) Any regulated articles except soil... Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... specifically authorized by the Deputy Administrator in emergency situations, soil samples for...

  4. 7 CFR 301.85-3 - Conditions governing the interstate movement of regulated articles from quarantined States. 2

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... applicable Federal domestic plant quarantines must also be met. (a) Any regulated articles except soil... Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... specifically authorized by the Deputy Administrator in emergency situations, soil samples for...

  5. 7 CFR 301.85-3 - Conditions governing the interstate movement of regulated articles from quarantined States. 2

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... applicable Federal domestic plant quarantines must also be met. (a) Any regulated articles except soil... Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... specifically authorized by the Deputy Administrator in emergency situations, soil samples for...

  6. Have government regulations improved workplace safety? A test of the asynchronous regulatory effects in China's coal industry, 1995-2006

    SciTech Connect

    Shi, X.P.

    2009-07-01

    Empirical studies on the effectiveness of workplace safety regulations are inconclusive. This study hypothesizes that the asynchronous effects of safety regulations occur because regulations need time to become effective. Safety regulations will work initially by reducing the most serious accidents, and later by improving overall safety performance. The hypothesis is tested by studying a provincial level aggregate panel dataset for China's coal industry using two different models with different sets of dependent variables: a fixed-effects model on mortality rate, which is defined as fatalities per 1,000 employees; and a negative binominal model on the annual number (frequency) of disastrous accidents. Safety regulations can reduce the frequency of disastrous accidents, but have not reduced mortality rate, which represents overall safety performance. Policy recommendations are made, including shifting production from small to large mines through industrial consolidation, improving the safety performance of large mines, addressing consequences of decentralization, and facilitating the implementation of regulations through carrying on institutional actions and supporting legislation.

  7. Spatial Phosphoprotein Profiling Reveals a Compartmentalized Extracellular Signal-regulated Kinase Switch Governing Neurite Growth and Retraction

    SciTech Connect

    Wang, Yingchun; Yang, Feng; Fu, Yi; Huang, Xiahe; Wang, Wei; Jiang, Xining; Gritsenko, Marina A.; Zhao, Rui; Monroe, Matthew E.; Pertz, Olivier C.; Purvine, Samuel O.; Orton, Daniel J.; Jacobs, Jon M.; Camp, David G.; Smith, Richard D.; Klemke, Richard L.

    2011-05-20

    Abstract - Brain development and spinal cord regeneration require neurite sprouting and growth cone navigation in response to extension and collapsing factors present in the extracellular environment. These external guidance cues control neurite growth cone extension and retraction processes through intracellular protein phosphorylation of numerous cytoskeletal, adhesion, and polarity complex signaling proteins. However, the complex kinase/substrate signaling networks that mediate neuritogenesis have not been investigated. Here, we compare the neurite phosphoproteome under growth and retraction conditions using neurite purification methodology combined with mass spectrometry. More than 4000 non-redundant phosphorylation sites from 1883 proteins have been annotated and mapped to signaling pathways that control kinase/phosphatase networks, cytoskeleton remodeling, and axon/dendrite specification. Comprehensive informatics and functional studies revealed a compartmentalized ERK activation/deactivation cytoskeletal switch that governs neurite growth and retraction, respectively. Our findings provide the first system-wide analysis of the phosphoprotein signaling networks that enable neurite growth and retraction and reveal an important molecular switch that governs neuritogenesis.

  8. 38 CFR Appendix B to Subpart E of... - List of Age Distinctions Contained in Statutes and Regulations Governing Federal Financial...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Section 90.31(f) of the governmentwide regulations (45 CFR part 90) requires each Federal agency to... Adjudication (38 CFR part 3) Section 3.57 defines the term “child” of a veteran as, “. . . an unmarried person... Adjudication (38 CFR part 3) Section 3.807(d) sets forth basic eligibility criteria for the program...

  9. 38 CFR Appendix B to Subpart E of... - List of Age Distinctions Contained in Statutes and Regulations Governing Federal Financial...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Section 90.31(f) of the governmentwide regulations (45 CFR part 90) requires each Federal agency to... Adjudication (38 CFR part 3) Section 3.57 defines the term “child” of a veteran as, “. . . an unmarried person... Adjudication (38 CFR part 3) Section 3.807(d) sets forth basic eligibility criteria for the program...

  10. 38 CFR Appendix B to Subpart E of... - List of Age Distinctions Contained in Statutes and Regulations Governing Federal Financial...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... veteran who meets the requirements of 38 CFR 3.57, except as to age or marital status 64.117 Survivors... Section 90.31(f) of the governmentwide regulations (45 CFR part 90) requires each Federal agency to... Adjudication (38 CFR part 3) Section 3.57 defines the term “child” of a veteran as, “. . . an unmarried...

  11. 7 CFR 301.80-3 - Conditions governing the interstate movement of regulated articles from quarantined States. 3

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... applicable Federal domestic plant quarantines must also be met. (a) Any regulated articles, except soil... Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... authorized by the Deputy Administrator in emergency situations, soil samples for processing, testing,...

  12. 7 CFR 301.92-4 - Conditions governing the interstate movement of regulated, restricted, and associated articles...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE DOMESTIC QUARANTINE NOTICES... all other applicable Federal domestic plant quarantines and regulations must also be met. (1) With a...) The nursery stock is not rooted in soil or growing media. 7 7 To be eligible for interstate...

  13. 7 CFR 301.80-3 - Conditions governing the interstate movement of regulated articles from quarantined States. 3

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... applicable Federal domestic plant quarantines must also be met. (a) Any regulated articles, except soil... Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... authorized by the Deputy Administrator in emergency situations, soil samples for processing, testing,...

  14. 7 CFR 301.80-3 - Conditions governing the interstate movement of regulated articles from quarantined States. 3

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... applicable Federal domestic plant quarantines must also be met. (a) Any regulated articles, except soil... Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... authorized by the Deputy Administrator in emergency situations, soil samples for processing, testing,...

  15. 7 CFR 301.80-3 - Conditions governing the interstate movement of regulated articles from quarantined States. 3

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... applicable Federal domestic plant quarantines must also be met. (a) Any regulated articles, except soil... Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... authorized by the Deputy Administrator in emergency situations, soil samples for processing, testing,...

  16. 7 CFR 301.92-4 - Conditions governing the interstate movement of regulated, restricted, and associated articles...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE DOMESTIC QUARANTINE NOTICES... all other applicable Federal domestic plant quarantines and regulations must also be met. (1) With a...) The nursery stock is not rooted in soil or growing media. 7 7 To be eligible for interstate...

  17. CpsR, a GntR family regulator, transcriptionally regulates capsular polysaccharide biosynthesis and governs bacterial virulence in Streptococcus pneumoniae

    PubMed Central

    Wu, Kaifeng; Xu, Hongmei; Zheng, Yuqiang; Wang, Libin; Zhang, Xuemei; Yin, Yibing

    2016-01-01

    Transcriptional regulation of capsule expression is critical for pneumococcal transition from carriage to infection, yet the underlying mechanism remains incompletely understood. Here, we describe the regulation of capsular polysaccharide, one of the most important pneumococcal virulence factor by a GntR family regulator, CpsR. Electrophoretic mobility-shift assays have shown the direct interaction between CpsR and the cps promoter (cpsp), and their interaction could be competitively interfered by glucose. DNase I footprinting assays localized the binding site to a region −146 to −114 base pairs relative to the transcriptional start site of the cps locus in S. pneumoniae D39. We found that CpsR negatively controlled the transcription of the cps locus and hence CPS production, which was confirmed by fine-tuning expression of CpsR in a ΔcpsR complemented strain. Increased expression of CpsR in complemented strain led to a decreased resistance to the whole-blood-mediated killing, suggesting a protective role for CpsR-cpsp interaction in the establishment of invasive infection. Finally, animal experiments showed that CpsR-cpsp interaction was necessary for both pneumococcal colonization and invasive infection. Taken together, our results provide a thorough insight into the regulation of capsule production mediated by CpsR and its important roles in pneumococcal pathogenesis. PMID:27386955

  18. Recent government regulations in the United States seek to ensure the effectiveness of antibiotics by limiting their agricultural use.

    PubMed

    Centner, Terence J

    2016-09-01

    The development of bacteria resistant to antibiotics is viewed as a medical health threat. Because thousands of people die every year due to antibiotic-resistant bacteria, efforts are underway to reduce antibiotic usage which in turn will reduce the development of antibiotic-resistant bacteria. In the United States, the use of antibiotics in the production of food animals to enhance animal growth has been identified as contributing to resistance. In 2015, a veterinary feed directive was adopted by the U.S. federal government prohibiting nontherapeutic uses of antibiotics in food animals that should reduce usage. The continued usage of antibiotics by producers for preventing disease may mean the directive is insufficient to reduce nontherapeutic antibiotic administration. This may lead some consumers to seek meat products from animals raised without antibiotics. A governmentally-sponsored labeling program could encourage reduction in antibiotic usage. PMID:27182666

  19. Reinventing government

    SciTech Connect

    Hanson, D.J.; Lepkowski, W.; Long, J.R.; Zurer, P.S.

    1993-10-11

    Both Clinton and Vice President Al Gore are committed to reinventing the federal government. To do so they will need more than a little help from Congress. But, if they succeed in turning the report's recommendations into reality, substantial change will occur in the way the federal government interacts with the chemical community in areas such as environmental and safety and health regulation, science and technology policy, education, and research priority setting. The report is the result of a six-month effort by the National Performance Review (NPR), a group led by Gore. It contains some 400 specific recommendations for changing the ways the federal government operates. These recommendations, if enacted the report claims, would produced savings of $108 billion over five years and reduce the size of the civilian, nonpostal work force by 12%, 252 positions, over the same period. The Department of Energy is the target of eight NPR recommendations. But the one with the most direct relevance to R and D calls for directing its national laboratories to pursue post-Cold War research priorities. Efforts to shift the labs away from their defense orientation began during the Carter presidency, when all of the labs began establishing stronger research programs in environmental science and technology and biology.

  20. Quorum-sensing regulation governs bacterial adhesion, biofilm development, and host colonization in Pantoea stewartii subspecies stewartii.

    PubMed

    Koutsoudis, Maria D; Tsaltas, Dimitrios; Minogue, Timothy D; von Bodman, Susanne B

    2006-04-11

    The phytopathogenic bacterium Pantoea stewartii subsp. stewartii synthesizes stewartan exo/capsular polysaccharide (EPS) in a cell density-dependent manner governed by the EsaI/EsaR quorum-sensing (QS) system. This study analyzes biofilm development and host colonization of the WT and QS regulatory mutant strains of P. stewartii. First, we show that the cell density-dependent synthesis of stewartan EPS, governed by the EsaI/EsaR QS system, is required for proper bacterial adhesion and development of spatially defined, 3D biofilms. Second, a nonvirulent mutant lacking the esaI gene adheres strongly to surfaces and develops densely packed, less structurally defined biofilms in vitro. This strain appears to be arrested in a low cell density developmental mode. Exposure of this strain to exogenous N-acyl-homoserine lactone counteracts this adhesion phenotype. Third, QS mutants lacking the EsaR repressor attach poorly to surfaces and form amorphous biofilms heavily enmeshed in excess EPS. Fourth, the WT strain disseminates efficiently within the xylem, primarily in a basipetal direction. In contrast, the two QS mutant strains remain largely localized at the site of infection. Fifth, and most significantly, epifluorescence microscopic imaging of infected leaf tissue and excised xylem vessels reveals that the bacteria colonize the xylem with unexpected specificity, particularly toward the annular rings and spiral secondary wall thickenings of protoxylem, as opposed to indiscriminate growth to fill the xylem lumen. These observations are significant to bacterial plant pathogenesis in general and may reveal targets for disease control. PMID:16585516

  1. The clinical governance of the soul: 'deep management' and the self-regulating subject in integrated community mental health teams.

    PubMed

    Brown, Brian; Crawford, Paul

    2003-01-01

    Health professionals have often been described as if they were in conflict with the new managerialist spirit in health care. However, because of their distributed and mobile sites of intervention, the work of community teams presents particular problems for traditional notions of management. In this UK study we identify how mental health team members are regulated by means of a subtle 'deep management'. Team members point to a lack of management direction from senior colleagues, even though some of them participate in the management process themselves. However, the lack of overt management leads them to prioritise clients and foreground professional identities in performing their duties and much additional administrative work besides. This also meant that the organisational structure-the team-was defined in subjective terms. Participants had become self-regulating 'deep managed' subjects under a largely hands-off management regime. PMID:12435552

  2. Regulators of G-protein signaling accelerate GPCR signaling kinetics and govern sensitivity solely by accelerating GTPase activity.

    PubMed

    Lambert, Nevin A; Johnston, Christopher A; Cappell, Steven D; Kuravi, Sudhakiranmayi; Kimple, Adam J; Willard, Francis S; Siderovski, David P

    2010-04-13

    G-protein heterotrimers, composed of a guanine nucleotide-binding G alpha subunit and an obligate G betagamma dimer, regulate signal transduction pathways by cycling between GDP- and GTP-bound states. Signal deactivation is achieved by G alpha-mediated GTP hydrolysis (GTPase activity) which is enhanced by the GTPase-accelerating protein (GAP) activity of "regulator of G-protein signaling" (RGS) proteins. In a cellular context, RGS proteins have also been shown to speed up the onset of signaling, and to accelerate deactivation without changing amplitude or sensitivity of the signal. This latter paradoxical activity has been variably attributed to GAP/enzymatic or non-GAP/scaffolding functions of these proteins. Here, we validated and exploited a G alpha switch-region point mutation, known to engender increased GTPase activity, to mimic in cis the GAP function of RGS proteins. While the transition-state, GDP x AlF(4)(-)-bound conformation of the G202A mutant was found to be nearly identical to wild-type, G alpha(i1)(G202A) x GDP assumed a divergent conformation more closely resembling the GDP x AlF(4)(-)-bound state. When placed within Saccharomyces cerevisiae G alpha subunit Gpa1, the fast-hydrolysis mutation restored appropriate dose-response behaviors to pheromone signaling in the absence of RGS-mediated GAP activity. A bioluminescence resonance energy transfer (BRET) readout of heterotrimer activation with high temporal resolution revealed that fast intrinsic GTPase activity could recapitulate in cis the kinetic sharpening (increased onset and deactivation rates) and blunting of sensitivity also engendered by RGS protein action in trans. Thus G alpha-directed GAP activity, the first biochemical function ascribed to RGS proteins, is sufficient to explain the activation kinetics and agonist sensitivity observed from G-protein-coupled receptor (GPCR) signaling in a cellular context. PMID:20351284

  3. REST-Governed Gene Expression Profiling in a Neuronal Cell Model Reveals Novel Direct and Indirect Processes of Repression and Up-Regulation

    PubMed Central

    Garcia-Manteiga, Jose M.; Bonfiglio, Silvia; Folladori, Lucrezia; Malosio, Maria L.; Lazarevic, Dejan; Stupka, Elia; Cittaro, Davide; Meldolesi, Jacopo

    2015-01-01

    The role of REST changes in neurons, including the rapid decrease of its level during differentiation and its fluctuations during many mature functions and diseases, is well established. However, identification of many thousand possible REST-target genes, mostly based on indirect criteria, and demonstration of their operative dependence on the repressor have been established for only a relatively small fraction. In the present study, starting from our recently published work, we have expanded the identification of REST-dependent genes, investigated in two clones of the PC12 line, a recognized neuronal cell model, spontaneously expressing different levels of REST: very low as in neurons and much higher as in most non-neural cells. The molecular, structural and functional differences of the two PC12 clones were shown to depend largely on their different REST level and the ensuing variable expression of some dependent genes. Comprehensive RNA-Seq analyses of the 13,700 genes expressed, validated by parallel RT-PCR and western analyses of mRNAs and encoded proteins, identified in the high-REST clone two groups of almost 900 repressed and up-regulated genes. Repression is often due to direct binding of REST to target genes; up-regulation to indirect mechanism(s) mostly mediated by REST repression of repressive transcription factors. Most, but not all, genes governing neurosecretion, excitability, and receptor channel signaling were repressed in the high REST clone. The genes governing expression of non-channel receptors (G protein-coupled and others), although variably affected, were often up-regulated together with the genes of intracellular kinases, small G proteins, cytoskeleton, cell adhesion, and extracellular matrix proteins. Expression of REST-dependent genes governing functions other than those mentioned so far were also identified. The results obtained by the parallel investigation of the two PC12 clones revealed the complexity of the REST molecular and

  4. 48 CFR 46.406 - Foreign governments.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Foreign governments. 46.406 Section 46.406 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT QUALITY ASSURANCE Government Contract Quality Assurance 46.406 Foreign governments. Government contract quality assurance performed for...

  5. Regulation of Endothelial Glutathione by ICAM-1 governs VEGF-A mediated eNOS Activity and Angiogenesis

    PubMed Central

    Langston, Will; Chidlow, John H.; Booth, Blake A.; Barlow, Shayne C.; Lefer, David J.; Patel, Rakesh P.; Kevil, Christopher G.

    2007-01-01

    Previous studies suggest that inflammatory cell adhesion molecules may modulate endothelial cell migration and angiogenesis through unknown mechanisms. Using a combination of in vitro and in vivo approaches, herein we reveal a novel redox sensitive mechanism by which ICAM-1 modulates endothelial GSH that controls VEGF-A induced eNOS activity, endothelial chemotaxis, and angiogenesis. In vivo disk angiogenesis assays showed attenuated VEGF-A mediated angiogenesis in ICAM-1−/− mice. Moreover, VEGF-A dependent chemotaxis, eNOS phosphorylation, and nitric oxide (NO) production were impaired in ICAM-1−/− MAEC compared to WT MAEC. Decreasing intracellular GSH in ICAM-1−/− MAEC to levels observed in WT MAEC with 150 μM buthionine sulfoximine (BSO) restored VEGF-A responses. Conversely, GSH supplementation of WT MAEC with 5 mM glutathione ethyl ester (GEE) mimicked defects observed in ICAM-1−/− cells. Deficient angiogenic responses in ICAM-1−/− cells were associated with increased expression of the lipid phosphatase, PTEN, consistent with antagonism of signaling pathways leading to eNOS activation. PTEN expression was also sensitive to GSH status, decreasing or increasing in proportion to intracellular GSH concentrations. These data suggest a novel role for ICAM-1 in modulating VEGF-A induced angiogenesis and eNOS activity through regulation of PTEN expression via modulation of intracellular GSH status. PMID:17291995

  6. An enzyme in the kynurenine pathway that governs vulnerability to suicidal behavior by regulating excitotoxicity and neuroinflammation.

    PubMed

    Brundin, L; Sellgren, C M; Lim, C K; Grit, J; Pålsson, E; Landén, M; Samuelsson, M; Lundgren, K; Brundin, P; Fuchs, D; Postolache, T T; Traskman-Bendz, L; Guillemin, G J; Erhardt, S

    2016-01-01

    Emerging evidence suggests that inflammation has a key role in depression and suicidal behavior. The kynurenine pathway is involved in neuroinflammation and regulates glutamate neurotransmission. In the cerebrospinal fluid (CSF) of suicidal patients, levels of inflammatory cytokines and the kynurenine metabolite quinolinic acid (QUIN), an N-methyl-d-aspartate receptor agonist, are increased. The enzyme amino-β-carboxymuconate-semialdehyde-decarboxylase (ACMSD) limits QUIN formation by competitive production of the neuroprotective metabolite picolinic acid (PIC). Therefore, decreased ACMSD activity can lead to excess QUIN. We tested the hypothesis that deficient ACMSD activity underlies suicidal behavior. We measured PIC and QUIN in CSF and plasma samples from 137 patients exhibiting suicidal behavior and 71 healthy controls. We used DSM-IV and the Montgomery-Åsberg Depression Rating Scale and Suicide Assessment Scale to assess behavioral changes. Finally, we genotyped ACMSD tag single-nucleotide polymorphisms (SNPs) in 77 of the patients and 150 population-based controls. Suicide attempters had reduced PIC and a decreased PIC/QUIN ratio in both CSF (P<0.001) and blood (P=0.001 and P<0.01, respectively). The reductions of PIC in CSF were sustained over 2 years after the suicide attempt based on repeated measures. The minor C allele of the ACMSD SNP rs2121337 was more prevalent in suicide attempters and associated with increased CSF QUIN. Taken together, our data suggest that increased QUIN levels may result from reduced activity of ACMSD in suicidal subjects. We conclude that measures of kynurenine metabolites can be explored as biomarkers of suicide risk, and that ACMSD is a potential therapeutic target in suicidal behavior. PMID:27483383

  7. Epigenetic Regulation of miRNA-211 by MMP-9 Governs Glioma Cell Apoptosis, Chemosensitivity and Radiosensitivity

    PubMed Central

    Asuthkar, Swapna; Velpula, Kiran Kumar; Chetty, Chandramu; Gorantla, Bharathi; Rao, Jasti S.

    2012-01-01

    Glioblastoma multiforme (GBM) is the most aggressive brain cancer, and to date, no curative treatment has been developed. In this study, we report that miR-211, a microRNA predicted to target MMP-9, is suppressed in grade IV GBM specimens. Furthermore, we found that miR-211 suppression in GBM involves aberrant methylation-mediated epigenetic silencing of the miR-211 promoter. Indeed, we observed a highly significant inverse correlation between miR-211 expression and MMP-9 protein levels, which is indicative of post-transcriptional control of gene expression. Additionally, shRNA specific for MMP-9 (pM) promoted miR-211 expression via demethylation of miR-211 promoter-associated CpG islands (-140 to +56). In independent experiments, we confirmed that miR-211 overexpression and pM treatments led to the activation of the intrinsic mitochondrial/Caspase-9/3-mediated apoptotic pathway in both glioma cells and cancer stem cells (CSC). We also investigated whether miR-211 is involved in the regulation of MMP-9 and thus plays a functional role in GBM. We found an acute inhibitory effect of miR-211 on glioma cell invasion and migration via suppression of MMP-9. Given the insensitivity of some GBMs to radiation and chemotherapy (temozolomide) along with the hypothesis that glioma CSC cause resistance to therapy, our study indicates that miR-211 or pM in combination with ionizing radiation (IR) and temozolomide significantly induces apoptosis and DNA fragmentation. Of note, miR-211- and pM-treated CSC demonstrated increased drug retention capacity, as observed by MDR1/P-gp mediated-Rhodamine 123 drug efflux activity assay. These results suggest that either rescuing miR-211 expression or downregulation of MMP-9 may have a new therapeutic application for GBM patients in the future. PMID:23183822

  8. Epigenetic regulation of miRNA-211 by MMP-9 governs glioma cell apoptosis, chemosensitivity and radiosensitivity.

    PubMed

    Asuthkar, Swapna; Velpula, Kiran Kumar; Chetty, Chandramu; Gorantla, Bharathi; Rao, Jasti S

    2012-11-01

    Glioblastoma multiforme (GBM) is the most aggressive brain cancer, and to date, no curative treatment has been developed. In this study, we report that miR-211, a microRNA predicted to target MMP-9, is suppressed in grade IV GBM specimens. Furthermore, we found that miR-211 suppression in GBM involves aberrant methylation-mediated epigenetic silencing of the miR-211 promoter. Indeed, we observed a highly significant inverse correlation between miR-211 expression and MMP-9 protein levels, which is indicative of post-transcriptional control of gene expression. Additionally, shRNA specific for MMP-9 (pM) promoted miR-211 expression via demethylation of miR-211 promoter-associated CpG islands (-140 to +56). In independent experiments, we confirmed that miR-211 overexpression and pM treatments led to the activation of the intrinsic mitochondrial/Caspase-9/3-mediated apoptotic pathway in both glioma cells and cancer stem cells (CSC). We also investigated whether miR-211 is involved in the regulation of MMP-9 and thus plays a functional role in GBM. We found an acute inhibitory effect of miR-211 on glioma cell invasion and migration via suppression of MMP-9. Given the insensitivity of some GBMs to radiation and chemotherapy (temozolomide) along with the hypothesis that glioma CSC cause resistance to therapy, our study indicates that miR-211 or pM in combination with ionizing radiation (IR) and temozolomide significantly induces apoptosis and DNA fragmentation. Of note, miR-211- and pM-treated CSC demonstrated increased drug retention capacity, as observed by MDR1/P-gp mediated-Rhodamine 123 drug efflux activity assay. These results suggest that either rescuing miR-211 expression or downregulation of MMP-9 may have a new therapeutic application for GBM patients in the future. PMID:23183822

  9. ESTABLISHING FINAL END STATE FOR A RETIRED NUCLEAR WEAPONS PRODUCTION REACTOR; COLLABORATION BETWEEN STAKEHOLDERS, REGULATORS, AND THE FEDERAL GOVERNMENT - 11052

    SciTech Connect

    Bergren, C.; Flora, M.; Belencan, H.

    2010-11-17

    The Savannah River Site (SRS) is a 310-square-mile United States Department of Energy nuclear facility located along the Savannah River (SRS) near Aiken, South Carolina. Nuclear weapons material production began in the early 1950s, utilizing five production reactors. In the early 1990s all SRS production reactor operations were terminated. The first reactor closure end state declaration was recently institutionalized in a Comprehensive Environmental Response and Compensation and Liability Act (CERCLA) Early Action Record of Decision. The decision for the final closure of the 318,000 square foot 105-P Reactor was determined to be in situ decommissioning (ISD). ISD is an acceptable and cost effective alternative to off-site disposal for the reactor building, which will allow for consolidation of remedial action wastes generated from other cleanup activities within the P Area. ISD is considered protective by the regulators, U. S. Environmental Protection Agency (US EPA) and the South Carolina Department of Health and Environmental Control (SCDHEC), public and stakeholders as waste materials are stabilized/immobilized, and radioactivity is allowed to naturally decay, thus preventing future exposure to the environment. Stakeholder buy-in was critical in the upfront planning in order to achieve this monumental final decision. Numerous public meetings and workshops were held in two different states (covering a 200 mile radius) with stakeholder and SRS Citizens Advisory Board participation. These meetings were conducted over an eight month period as the end state decision making progressed. Information provided to the public evolved from workshop to workshop as data became available and public input from the public meetings were gathered. ISD is being considered for the balance of the four SRS reactors and other hardened facilities such as the chemical Separation Facilities (canyons).

  10. ESTABLISHING FINAL END STATE FOR A RETIRED NUCLEAR WEAPONS PRODUCTION REACTOR; COLLABORATION BETWEEN STAKEHOLDERS, REGULATORS AND THE FEDERAL GOVERNMENT

    SciTech Connect

    Bergren, C

    2009-01-16

    The Savannah River Site (SRS) is a 310-square-mile United States Department of Energy nuclear facility located along the Savannah River (SRS) near Aiken, South Carolina. Nuclear weapons material production began in the early 1950s, utilizing five production reactors. In the early 1990s all SRS production reactor operations were terminated. The first reactor closure end state declaration was recently institutionalized in a Comprehensive Environmental Response and Compensation and Liability Act (CERCLA) Early Action Record of Decision. The decision for the final closure of the 318,000 square foot 105-P Reactor was determined to be in situ decommissioning (ISD). ISD is an acceptable and cost effective alternative to off-site disposal for the reactor building, which will allow for consolidation of remedial action wastes generated from other cleanup activities within the P Area. ISD is considered protective by the regulators, U. S. Environmental Protection Agency (US EPA) and the South Carolina Department of Health and Environmental Control (SCDHEC), public and stakeholders as waste materials are stabilized/immobilized, and radioactivity is allowed to naturally decay, thus preventing future exposure to the environment. Stakeholder buy-in was critical in the upfront planning in order to achieve this monumental final decision. Numerous public meetings and workshops were held in two different states (covering a 200 mile radius) with stakeholder and SRS Citizens Advisory Board participation. These meetings were conducted over an eight month period as the end state decision making progressed. Information provided to the public evolved from workshop to workshop as data became available and public input from the public meetings were gathered. ISD is being considered for the balance of the four SRS reactors and other hardened facilities such as the chemical processing canyons.

  11. 48 CFR 225.7303-3 - Government-to-government agreements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Government-to-government... Military Sales 225.7303-3 Government-to-government agreements. If a government-to-government agreement between the United States and a foreign government for the sale, coproduction, or cooperative...

  12. 48 CFR 225.7303-3 - Government-to-government agreements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Government-to-government... Military Sales 225.7303-3 Government-to-government agreements. If a government-to-government agreement between the United States and a foreign government for the sale, coproduction, or cooperative...

  13. 48 CFR 225.7303-3 - Government-to-government agreements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Government-to-government... Military Sales 225.7303-3 Government-to-government agreements. If a government-to-government agreement between the United States and a foreign government for the sale, coproduction, or cooperative...

  14. 48 CFR 225.7303-3 - Government-to-government agreements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Government-to-government... Military Sales 225.7303-3 Government-to-government agreements. If a government-to-government agreement between the United States and a foreign government for the sale, coproduction, or cooperative...

  15. 48 CFR 225.7303-3 - Government-to-government agreements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Government-to-government... Military Sales 225.7303-3 Government-to-government agreements. If a government-to-government agreement between the United States and a foreign government for the sale, coproduction, or cooperative...

  16. The master regulator for biofilm formation in Bacillus subtilis governs the expression of an operon encoding secreted proteins required for the assembly of complex multicellular communities.

    SciTech Connect

    Branda, Steven S.; Losick, Richard; Kolter, Roberto; Kearns, Daniel B.; Chu, Frances

    2005-08-01

    Wild strains of Bacillus subtilis are capable of forming architecturally complex communities of cells known as biofilms. Critical to biofilm formation is the eps operon, which is believed to be responsible for the biosynthesis of an exopolysaccharide that binds chains of cells together in bundles. We report that transcription of eps is under the negative regulation of SinR, a repressor that was found to bind to multiple sites in the regulatory region of the operon. Mutations in sinR bypassed the requirement in biofilm formation of two genes of unknown function, ylbF and ymcA, and sinI, which is known to encode an antagonist of SinR. We propose that these genes are members of a pathway that is responsible for counteracting SinR-mediated repression. We further propose that SinR is a master regulator that governs the transition between a planktonic state in which the bacteria swim as single cells in liquid or swarm in small groups over surfaces, and a sessile state in which the bacteria adhere to each other to form bundled chains and assemble into multicellular communities.

  17. The case for OFSMOKE: how tobacco price regulation is needed to promote the health of markets, government revenue and the public

    PubMed Central

    Branston, J Robert; Sweanor, David

    2010-01-01

    Mainstream economic theory outlines four main causes of market failure and it is already well established that two of these (information failure and externalities) exist in a tobacco market. A third cause of market failure, market power, is also a serious problem in many tobacco markets. Market power—combined with unintended and often overlooked consequences of tobacco tax policies, notably that gradual increases in specific taxes may allow the industry to disguise significant price increases—has, at least in high income countries, given cigarette manufacturers considerable pricing power and profits. This paper examines ways this market failure could be addressed and proposes as a solution a system of price cap regulation wherein a cap is placed on the pre-tax cigarette manufacturers' price but not on the retail price that consumers face. Well established in the utilities industry, price cap regulation would set a maximum price that cigarette companies can charge for their product based on an assessment of the genuine costs each firm faces in its operations and an assumption about the efficiency savings it would be expected to make. Such a system would achieve three main benefits. First, it would address the problem of market failure and excess profits while simultaneously allowing current tobacco control policies, including tax and price increases, to expand—thus tax increases would remain a central tenet of tobacco control policies and retail prices could continue to increase. Second, it would increase government revenue by transferring the excess profits from the industry to the government purse. Third, it would bring numerous public health benefits. In addition to addressing market power, while simultaneously allowing tobacco control policies to expand, it could offer a means of preventing down-trading to cheaper products and controlling unwanted industry practices such as cigarette smuggling, price fixing and marketing to the young. The paper outlines in

  18. To Government Regulations Be True.

    ERIC Educational Resources Information Center

    Gardner, Carrie

    2002-01-01

    Describes school-district compliance requirements for two recently enacted federal laws designed to protect children from obscene, pornographic, or harmful materials available on the Internet: Children's Internet Protection Act and Neighborhood Children's Internet Protection Act. District eligibility for federal funds, including the E-rate…

  19. Student Government.

    ERIC Educational Resources Information Center

    Morrow, Joyce

    Materials for running a student government program at the junior high school level are provided in three general sections. Section 1 is a description of student government operations. Topics covered include student government responsibilities and activities, student council meeting procedures, parliamentary rules, responsibilities of the…

  20. 48 CFR 46.406 - Foreign governments.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Foreign governments. 46... MANAGEMENT QUALITY ASSURANCE Government Contract Quality Assurance 46.406 Foreign governments. Government contract quality assurance performed for foreign governments or international agencies shall...

  1. 48 CFR 46.406 - Foreign governments.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Foreign governments. 46... MANAGEMENT QUALITY ASSURANCE Government Contract Quality Assurance 46.406 Foreign governments. Government contract quality assurance performed for foreign governments or international agencies shall...

  2. 48 CFR 46.406 - Foreign governments.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Foreign governments. 46... MANAGEMENT QUALITY ASSURANCE Government Contract Quality Assurance 46.406 Foreign governments. Government contract quality assurance performed for foreign governments or international agencies shall...

  3. 48 CFR 46.406 - Foreign governments.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Foreign governments. 46... MANAGEMENT QUALITY ASSURANCE Government Contract Quality Assurance 46.406 Foreign governments. Government contract quality assurance performed for foreign governments or international agencies shall...

  4. Representation and Misrepresentation of Scientific Evidence in Contemporary Tobacco Regulation: A Review of Tobacco Industry Submissions to the UK Government Consultation on Standardised Packaging

    PubMed Central

    Ulucanlar, Selda; Fooks, Gary J.; Hatchard, Jenny L.; Gilmore, Anna B.

    2014-01-01

    Background Standardised packaging (SP) of tobacco products is an innovative tobacco control measure opposed by transnational tobacco companies (TTCs) whose responses to the UK government's public consultation on SP argued that evidence was inadequate to support implementing the measure. The government's initial decision, announced 11 months after the consultation closed, was to wait for ‘more evidence’, but four months later a second ‘independent review’ was launched. In view of the centrality of evidence to debates over SP and TTCs' history of denying harms and manufacturing uncertainty about scientific evidence, we analysed their submissions to examine how they used evidence to oppose SP. Methods and Findings We purposively selected and analysed two TTC submissions using a verification-oriented cross-documentary method to ascertain how published studies were used and interpretive analysis with a constructivist grounded theory approach to examine the conceptual significance of TTC critiques. The companies' overall argument was that the SP evidence base was seriously flawed and did not warrant the introduction of SP. However, this argument was underpinned by three complementary techniques that misrepresented the evidence base. First, published studies were repeatedly misquoted, distorting the main messages. Second, ‘mimicked scientific critique’ was used to undermine evidence; this form of critique insisted on methodological perfection, rejected methodological pluralism, adopted a litigation (not scientific) model, and was not rigorous. Third, TTCs engaged in ‘evidential landscaping’, promoting a parallel evidence base to deflect attention from SP and excluding company-held evidence relevant to SP. The study's sample was limited to sub-sections of two out of four submissions, but leaked industry documents suggest at least one other company used a similar approach. Conclusions The TTCs' claim that SP will not lead to public health benefits is largely

  5. Governance and Institutional Autonomy: Governing and Governance in Portuguese Higher Education

    ERIC Educational Resources Information Center

    Magalhaes, Antonio; Veiga, Amelia; Ribeiro, Filipa; Amaral, Alberto

    2013-01-01

    This paper aims at looking at governance instruments beyond managerial technicality. It intends to do so by analysing the impact of governance reforms on the universities autonomy assumed as a regulation instrument to politically steer systems and institutions. The regulation efforts undertaken at the European and national levels reflect a trend…

  6. 48 CFR 245.602 - Reutilization of Government property.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Government property. 245.602 Section 245.602 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT GOVERNMENT PROPERTY Reporting, Reutilization, and Disposal 245.602 Reutilization of Government property....

  7. 48 CFR 245.602 - Reutilization of Government property.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Government property. 245.602 Section 245.602 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT GOVERNMENT PROPERTY Reporting, Reutilization, and Disposal 245.602 Reutilization of Government property....

  8. 48 CFR 245.602 - Reutilization of Government property.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Government property. 245.602 Section 245.602 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT GOVERNMENT PROPERTY Reporting, Reutilization, and Disposal 245.602 Reutilization of Government property....

  9. Remaking Governance.

    ERIC Educational Resources Information Center

    Carver, John

    2000-01-01

    The Policy Governance model's philosophical foundations lie in Rousseau's social contract, Greenleaf's servant-leadership, and modern management theory. Policy Governance stresses primacy of the owner-representative role; full-board authority; superintendents as chief executive officers; authoritative prescription of "ends," bounded freedom for…

  10. Reinventing Government.

    ERIC Educational Resources Information Center

    Osborne, David T.

    1993-01-01

    Throughout all levels of American government, a shift is taking place from the rigid, wasteful, centralized bureaucracies of the industrial era to the more flexible, entrepreneurial, decentralized government needed to succeed in today's world. This shift has been brought about by an unprecedented, ongoing fiscal crisis that has created a sudden…

  11. Biology and the Government

    ERIC Educational Resources Information Center

    Reid, Roger D.

    1969-01-01

    Emphasizes the social implications of biological knowledge and discusses two main government roles in biology: (1) a creative and supportive role, including support of education and research, (2) control, regulation and protection related to the applications of biological knowledge. Public control is considered necessary in areas such as food and…

  12. States turn up the heat. As self-regulation sputters, state legislatures are leading charge for more accountability in governance of not-for-profit hospitals.

    PubMed

    Mantone, Joseph

    2006-01-30

    Recent scandals have pushed some states to tackle transparency and governance issues at healthcare not-for-profits, which the federal government has been reluctant to touch. Rhode Island Lt. Gov. Charles Fogarty, left, supports a bill in his state that would establish a code of ethics for hospital boards. Fogarty sees leaders as getting too comfortable in their jobs and working without accountability. PMID:16479771

  13. 31 CFR 575.304 - Entity of the Government of Iraq; Iraqi Government entity.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Entity of the Government of Iraq... SANCTIONS REGULATIONS General Definitions § 575.304 Entity of the Government of Iraq; Iraqi Government entity. The term entity of the Government of Iraq or Iraqi Government entity includes: (a)...

  14. Governing the Governance of Education: The State Strikes Back?

    ERIC Educational Resources Information Center

    Hudson, Christine

    2007-01-01

    In many countries, there have been changes in the way in which education is governed, with greater fragmentation of responsibility between the state, local government, schools, individuals and the market often accompanied by a move from detailed regulation to framework legislation. Previously, these developments have been seen as part of the move…

  15. 48 CFR 51.103 - Ordering from Government supply sources.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Ordering from Government supply sources. 51.103 Section 51.103 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT USE OF GOVERNMENT SOURCES BY CONTRACTORS Contractor Use of Government Supply Sources 51.103 Ordering from Government...

  16. Hypothesis: Low frequency heart rate variability (LF-HRV) is an input for undisclosed yet biological adaptive control, governing the cardiovascular regulations to assure optimal functioning.

    PubMed

    Gabbay, Uri; Bobrovsky, Ben Zion

    2012-02-01

    Cardiovascular regulation is considered today as having three levels: autoregulations, neural regulations and hormonal regulations. We hypothesize that the cardiovascular regulation has an additional (fourth) control level which is outer, hierarchical (adaptive) loop where LF-HRV amplitude serves as a reference input which the neural cardiovascular center detects and responses in order to maintain LF-HRV around some prescribed level. Supporting evidences: LF-HRV absence during artificial cardiac pacing may be associated with "pacemaker syndrome" which had not been sufficiently understood regardless of apparently unimpaired cardiovascular performance. The hypothesis may provide an essential basis for understanding several cardiovascular morbidities and insight toward diagnostic measures and treatments (including but not limited to adding variability to the pulse generator of artificial pacemakers to eliminate "pace maker syndrome"). PMID:22100632

  17. 48 CFR 945.602 - Reutilization of Government property.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Government property. 945.602 Section 945.602 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CONTRACT MANAGEMENT GOVERNMENT PROPERTY Reporting, Reutilization, and Disposal 945.602 Reutilization of Government property....

  18. 48 CFR 945.602 - Reutilization of Government property.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Government property. 945.602 Section 945.602 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CONTRACT MANAGEMENT GOVERNMENT PROPERTY Reporting, Reutilization, and Disposal 945.602 Reutilization of Government property....

  19. The Aspergillus fumigatus StuA Protein Governs the Up-Regulation of a Discrete Transcriptional Program during the Acquisition of Developmental CompetenceD⃞

    PubMed Central

    Sheppard, Donald C.; Doedt, Thomas; Chiang, Lisa Y.; Kim, H. Stanley; Chen, Dan; Nierman, William C.; Filler, Scott G.

    2005-01-01

    Members of the Asm1p, Phd1p, Sok2p, Efg1p, and StuAp (APSES) family of fungal proteins regulate morphogenesis and virulence in ascomycetes. We cloned the Aspergillus fumigatus APSES gene encoding StuAp and demonstrated that stuA transcription is markedly up-regulated after the acquisition of developmental competence. A. fumigatus ΔstuA mutants were impaired in their ability to undergo asexual reproduction. Conidiophore morphology was markedly abnormal, and only small numbers of dysmorphic conidia were produced, which exhibited precocious germination. Whole genome transcriptional analysis during the onset of developmental competence was performed and identified a subset of developmentally regulated genes that were stuA dependent, including a cluster of putative secondary metabolite biosynthesis genes, genes encoding proteins implicated in the regulation of morphogenesis, and genes encoding allergens and other antigenic proteins. Additionally, hyphae of the ΔstuA mutant displayed reduced expression of the catalase gene CAT1 and were hypersusceptible to hydrogen peroxide. PMID:16207816

  20. Government Regulation and the First Amendment Religion Clauses--An Analysis of the NLRB Jurisdiction over Parochial Schools and Their Teachers.

    ERIC Educational Resources Information Center

    Bastress, Robert M., Jr.

    1978-01-01

    This article maintains that National Labor Relations Board regulation of parochial schools and teachers impermissibly intrudes on the decision-making processes that the First Amendment has committed to private individuals and institutions. Available from Duquesne Law Review, 901 Rockwell Hall, 600 Forbes Avenue, Pittsburgh, Pennsylvania 15219; sc…

  1. 48 CFR 1845.7210 - Contractor utilization of Government property.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Contractor utilization of Government property. 1845.7210 Section 1845.7210 Federal Acquisition Regulations System NATIONAL AERONAUTICS....7210 Contractor utilization of Government property....

  2. 48 CFR 246.470 - Government contract quality assurance actions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... quality assurance actions. 246.470 Section 246.470 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT QUALITY ASSURANCE Government Contract Quality Assurance 246.470 Government contract quality assurance actions....

  3. 5 CFR 2635.704 - Use of Government property.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... regulation. Example 1: Under regulations of the General Services Administration at 41 CFR 101-35.201, an... includes office supplies, telephone and other telecommunications equipment and services, the Government mails, automated data processing capabilities, printing and reproduction facilities, Government...

  4. 5 CFR 2635.704 - Use of Government property.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... regulation. Example 1: Under regulations of the General Services Administration at 41 CFR 101-35.201, an... includes office supplies, telephone and other telecommunications equipment and services, the Government mails, automated data processing capabilities, printing and reproduction facilities, Government...

  5. 5 CFR 2635.704 - Use of Government property.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... regulation. Example 1: Under regulations of the General Services Administration at 41 CFR 101-35.201, an... includes office supplies, telephone and other telecommunications equipment and services, the Government mails, automated data processing capabilities, printing and reproduction facilities, Government...

  6. 5 CFR 2635.704 - Use of Government property.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... regulation. Example 1: Under regulations of the General Services Administration at 41 CFR 101-35.201, an... includes office supplies, telephone and other telecommunications equipment and services, the Government mails, automated data processing capabilities, printing and reproduction facilities, Government...

  7. 48 CFR 2845.505-14 - Report of Government Property.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Report of Government Property. 2845.505-14 Section 2845.505-14 Federal Acquisition Regulations System DEPARTMENT OF JUSTICE CONTRACT MANAGEMENT GOVERNMENT PROPERTY Management of Government Property in the Possession of Contractors 2845.505-14 Report of Government Property....

  8. Mitogen-Dependent Regulation of DUSP1 Governs ERK and p38 Signaling During Early 3T3-L1 Adipocyte Differentiation.

    PubMed

    Ferguson, Bradley S; Nam, Heesun; Stephens, Jacqueline M; Morrison, Ron F

    2016-07-01

    Knowledge concerning mechanisms that control proliferation and differentiation of preadipocytes is essential to our understanding of adipocyte hyperplasia and the development of obesity. Evidence has shown that temporal regulation of mitogen-activated protein kinase (MAPK) phosphorylation and dephosphorylation is critical for coupling extracellular stimuli to cellular growth and differentiation. Using differentiating 3T3-L1 preadipocytes as a model of adipocyte hyperplasia, we examined a role for dual-specificity phosphatase 1 (DUSP1) on the timely modulation of MAPK signaling during states of growth arrest, proliferation, and differentiation. Using real-time reverse transcription PCR (qRT-PCR), we report that DUSP1 is induced during early preadipocyte proliferation concomitant with ERK and p38 dephosphorylation. As deactivation of ERK and p38 is essential for the progression of adipocyte differentiation, we further showed that de novo mRNA synthesis was required for ERK and p38 dephosphorylation, suggesting a role for "inducible" phosphatases in regulating MAPK signaling. Pharmacological and genetic inhibition of DUSP1 markedly increased ERK and p38 phosphorylation during early adipocyte differentiation. Based on these findings, we postulated that loss of DUSP1 would block adipocyte hyperplasia. However, genetic loss of DUSP1 was not sufficient to prevent preadipocyte proliferation or differentiation, suggesting a role for other phosphatases in the regulation of adipogenesis. In support of this, qRT-PCR identified several MAPK-specific DUSPs induced during early (DUSP2, -4, -5, & -6), mid (DUSP4 & -16) and late (DUSP9) stages of adipocyte differentiation. Collectively, these data suggest an important role for DUSPs in regulating MAPK dephosphorylation, with an emphasis on DUSP1, during early adipogenesis. PMID:26566083

  9. 7 CFR 3015.191 - Governments.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 15 2011-01-01 2011-01-01 false Governments. 3015.191 Section 3015.191 Agriculture... AGRICULTURE UNIFORM FEDERAL ASSISTANCE REGULATIONS Cost Principles § 3015.191 Governments. (a) OMB Circular No... be used in determining the allowable costs of activities conducted by governments. (b)...

  10. 48 CFR 246.406 - Foreign governments.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Foreign governments. 246..., DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT QUALITY ASSURANCE Government Contract Quality Assurance 246.406 Foreign governments. (1) Quality assurance among North Atlantic Treaty Organization (NATO) countries....

  11. 7 CFR 3015.191 - Governments.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Governments. 3015.191 Section 3015.191 Agriculture... AGRICULTURE UNIFORM FEDERAL ASSISTANCE REGULATIONS Cost Principles § 3015.191 Governments. (a) OMB Circular No... be used in determining the allowable costs of activities conducted by governments. (b)...

  12. 48 CFR 246.406 - Foreign governments.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Foreign governments. 246..., DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT QUALITY ASSURANCE Government Contract Quality Assurance 246.406 Foreign governments. (1) Quality assurance among North Atlantic Treaty Organization (NATO) countries....

  13. 7 CFR 3015.191 - Governments.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 15 2013-01-01 2013-01-01 false Governments. 3015.191 Section 3015.191 Agriculture... AGRICULTURE UNIFORM FEDERAL ASSISTANCE REGULATIONS Cost Principles § 3015.191 Governments. (a) OMB Circular No... be used in determining the allowable costs of activities conducted by governments. (b)...

  14. 48 CFR 836.572 - Government supervision.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Government supervision... CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS Contract Clauses 836.572 Government supervision. The contracting officer shall insert the clause at 852.236-78, Government supervision,...

  15. 48 CFR 246.406 - Foreign governments.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Foreign governments. 246..., DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT QUALITY ASSURANCE Government Contract Quality Assurance 246.406 Foreign governments. (1) Quality assurance among North Atlantic Treaty Organization (NATO) countries....

  16. 48 CFR 836.572 - Government supervision.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Government supervision... CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS Contract Clauses 836.572 Government supervision. The contracting officer shall insert the clause at 852.236-78, Government supervision,...

  17. 48 CFR 246.406 - Foreign governments.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Foreign governments. 246..., DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT QUALITY ASSURANCE Government Contract Quality Assurance 246.406 Foreign governments. (1) Quality assurance among North Atlantic Treaty Organization (NATO) countries....

  18. 7 CFR 3015.191 - Governments.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 15 2014-01-01 2014-01-01 false Governments. 3015.191 Section 3015.191 Agriculture... AGRICULTURE UNIFORM FEDERAL ASSISTANCE REGULATIONS Cost Principles § 3015.191 Governments. (a) OMB Circular No... be used in determining the allowable costs of activities conducted by governments. (b)...

  19. 48 CFR 836.572 - Government supervision.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Government supervision... CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS Contract Clauses 836.572 Government supervision. The contracting officer shall insert the clause at 852.236-78, Government supervision,...

  20. 48 CFR 836.572 - Government supervision.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Government supervision... CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS Contract Clauses 836.572 Government supervision. The contracting officer shall insert the clause at 852.236-78, Government supervision,...

  1. 7 CFR 3015.191 - Governments.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 15 2012-01-01 2012-01-01 false Governments. 3015.191 Section 3015.191 Agriculture... AGRICULTURE UNIFORM FEDERAL ASSISTANCE REGULATIONS Cost Principles § 3015.191 Governments. (a) OMB Circular No... be used in determining the allowable costs of activities conducted by governments. (b)...

  2. 48 CFR 1352.245-70 - Government furnished property.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Government furnished property. As prescribed in 48 CFR 1345.107-70, insert the following clause: Government Furnished Property (APR 2010) The Government will provide the following item(s) of Government property to... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Government...

  3. 48 CFR 1845.502-1 - Receipts for Government property.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Receipts for Government... SPACE ADMINISTRATION CONTRACT MANAGEMENT GOVERNMENT PROPERTY Management of Government Property in the Possession of Contractors 1845.502-1 Receipts for Government property. Receipts for Government property...

  4. 48 CFR 1345.107-70 - Government furnished property.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Government furnished... CONTRACT MANAGEMENT GOVERNMENT PROPERTY General 1345.107-70 Government furnished property. Insert clause 1352.245-70, Government Furnished Property, when Government property is to be furnished to...

  5. 48 CFR 1352.245-70 - Government furnished property.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Government furnished property. As prescribed in 48 CFR 1345.107-70, insert the following clause: Government Furnished Property (APR 2010) The Government will provide the following item(s) of Government property to... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Government...

  6. 48 CFR 1352.245-70 - Government furnished property.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Government furnished property. As prescribed in 48 CFR 1345.107-70, insert the following clause: Government Furnished Property (APR 2010) The Government will provide the following item(s) of Government property to... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Government...

  7. 48 CFR 1345.107-70 - Government furnished property.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Government furnished... CONTRACT MANAGEMENT GOVERNMENT PROPERTY General 1345.107-70 Government furnished property. Insert clause 1352.245-70, Government Furnished Property, when Government property is to be furnished to...

  8. 48 CFR 1352.245-70 - Government furnished property.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Government furnished property. As prescribed in 48 CFR 1345.107-70, insert the following clause: Government Furnished Property (APR 2010) The Government will provide the following item(s) of Government property to... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Government...

  9. 48 CFR 1345.107-70 - Government furnished property.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Government furnished... CONTRACT MANAGEMENT GOVERNMENT PROPERTY General 1345.107-70 Government furnished property. Insert clause 1352.245-70, Government Furnished Property, when Government property is to be furnished to...

  10. 48 CFR 836.572 - Government supervision.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Government supervision. 836.572 Section 836.572 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS SPECIAL... supervision. The contracting officer shall insert the clause at 852.236-78, Government supervision,...

  11. Integrative genomic analysis in K562 chronic myelogenous leukemia cells reveals that proximal NCOR1 binding positively regulates genes that govern erythroid differentiation and Imatinib sensitivity

    PubMed Central

    Long, Mark D.; van den Berg, Patrick R.; Russell, James L.; Singh, Prashant K.; Battaglia, Sebastiano; Campbell, Moray J.

    2015-01-01

    To define the functions of NCOR1 we developed an integrative analysis that combined ENCODE and NCI-60 data, followed by in vitro validation. NCOR1 and H3K9me3 ChIP-Seq, FAIRE-seq and DNA CpG methylation interactions were related to gene expression using bootstrapping approaches. Most NCOR1 combinations (24/44) were associated with significantly elevated level expression of protein coding genes and only very few combinations related to gene repression. DAVID's biological process annotation revealed that elevated gene expression was uniquely associated with acetylation and ETS binding. A matrix of gene and drug interactions built on NCI-60 data identified that Imatinib significantly targeted the NCOR1 governed transcriptome. Stable knockdown of NCOR1 in K562 cells slowed growth and significantly repressed genes associated with NCOR1 cistrome, again, with the GO terms acetylation and ETS binding, and significantly dampened sensitivity to Imatinib-induced erythroid differentiation. Mining public microarray data revealed that NCOR1-targeted genes were significantly enriched in Imatinib response gene signatures in cell lines and chronic myelogenous leukemia (CML) patients. These approaches integrated cistrome, transcriptome and drug sensitivity relationships to reveal that NCOR1 function is surprisingly most associated with elevated gene expression, and that these targets, both in CML cell lines and patients, associate with sensitivity to Imatinib. PMID:26117541

  12. A Nucleus-Encoded Chloroplast Protein Regulated by Iron Availability Governs Expression of the Photosystem I Subunit PsaA in Chlamydomonas reinhardtii1

    PubMed Central

    Lefebvre-Legendre, Linnka; Choquet, Yves; Kuras, Richard; Loubéry, Sylvain; Douchi, Damien; Goldschmidt-Clermont, Michel

    2015-01-01

    The biogenesis of the photosynthetic electron transfer chain in the thylakoid membranes requires the concerted expression of genes in the chloroplast and the nucleus. Chloroplast gene expression is subjected to anterograde control by a battery of nucleus-encoded proteins that are imported in the chloroplast, where they mostly intervene at posttranscriptional steps. Using a new genetic screen, we identify a nuclear mutant that is required for expression of the PsaA subunit of photosystem I (PSI) in the chloroplast of Chlamydomonas reinhardtii. This mutant is affected in the stability and translation of psaA messenger RNA. The corresponding gene, TRANSLATION OF psaA1 (TAA1), encodes a large protein with two domains that are thought to mediate RNA binding: an array of octatricopeptide repeats (OPR) and an RNA-binding domain abundant in apicomplexans (RAP) domain. We show that as expected for its function, TAA1 is localized in the chloroplast. It was previously shown that when mixotrophic cultures of C. reinhardtii (which use both photosynthesis and mitochondrial respiration for growth) are shifted to conditions of iron limitation, there is a strong decrease in the accumulation of PSI and that this is rapidly reversed when iron is resupplied. Under these conditions, TAA1 protein is also down-regulated through a posttranscriptional mechanism and rapidly reaccumulates when iron is restored. These observations reveal a concerted regulation of PSI and of TAA1 in response to iron availability. PMID:25673777

  13. 48 CFR 246.408 - Single-agency assignments of Government contract quality assurance.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... of Government contract quality assurance. 246.408 Section 246.408 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT QUALITY ASSURANCE Government Contract Quality Assurance 246.408 Single-agency assignments of Government...

  14. 48 CFR 1545.309 - Providing Government production and research property under special restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Regulations System ENVIRONMENTAL PROTECTION AGENCY CONTRACT MANAGEMENT GOVERNMENT PROPERTY Providing Government Property to Contractors 1545.309 Providing Government production and research property under... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Providing...

  15. 48 CFR 1545.309 - Providing Government production and research property under special restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Regulations System ENVIRONMENTAL PROTECTION AGENCY CONTRACT MANAGEMENT GOVERNMENT PROPERTY Providing Government Property to Contractors 1545.309 Providing Government production and research property under... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Providing...

  16. 48 CFR 1545.309 - Providing Government production and research property under special restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Regulations System ENVIRONMENTAL PROTECTION AGENCY CONTRACT MANAGEMENT GOVERNMENT PROPERTY Providing Government Property to Contractors 1545.309 Providing Government production and research property under... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Providing...

  17. 48 CFR 1545.309 - Providing Government production and research property under special restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Regulations System ENVIRONMENTAL PROTECTION AGENCY CONTRACT MANAGEMENT GOVERNMENT PROPERTY Providing Government Property to Contractors 1545.309 Providing Government production and research property under... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Providing...

  18. Fission Yeast SCYL1/2 Homologue Ppk32: A Novel Regulator of TOR Signalling That Governs Survival during Brefeldin A Induced Stress to Protein Trafficking.

    PubMed

    Kowalczyk, Katarzyna M; Petersen, Janni

    2016-05-01

    Target of Rapamycin (TOR) signalling allows eukaryotic cells to adjust cell growth in response to changes in their nutritional and environmental context. The two distinct TOR complexes (TORC1/2) localise to the cell's internal membrane compartments; the endoplasmic reticulum (ER), Golgi apparatus and lysosomes/vacuoles. Here, we show that Ppk32, a SCYL family pseudo-kinase, is a novel regulator of TOR signalling. The absence of ppk32 expression confers resistance to TOR inhibition. Ppk32 inhibition of TORC1 is critical for cell survival following Brefeldin A (BFA) induced stress. Treatment of wild type cells with either the TORC1 specific inhibitor rapamycin or the general TOR inhibitor Torin1 confirmed that a reduction in TORC1 activity promoted recovery from BFA induced stress. Phosphorylation of Ppk32 on two residues that are conserved within the SCYL pseudo-kinase family are required for this TOR inhibition. Phosphorylation on these sites controls Ppk32 protein levels and sensitivity to BFA. BFA induced ER stress does not account for the response to BFA that we report here, however BFA is also known to induce Golgi stress and impair traffic to lysosomes. In summary, Ppk32 reduce TOR signalling in response to BFA induced stress to support cell survival. PMID:27191590

  19. Fission Yeast SCYL1/2 Homologue Ppk32: A Novel Regulator of TOR Signalling That Governs Survival during Brefeldin A Induced Stress to Protein Trafficking

    PubMed Central

    Petersen, Janni

    2016-01-01

    Target of Rapamycin (TOR) signalling allows eukaryotic cells to adjust cell growth in response to changes in their nutritional and environmental context. The two distinct TOR complexes (TORC1/2) localise to the cell’s internal membrane compartments; the endoplasmic reticulum (ER), Golgi apparatus and lysosomes/vacuoles. Here, we show that Ppk32, a SCYL family pseudo-kinase, is a novel regulator of TOR signalling. The absence of ppk32 expression confers resistance to TOR inhibition. Ppk32 inhibition of TORC1 is critical for cell survival following Brefeldin A (BFA) induced stress. Treatment of wild type cells with either the TORC1 specific inhibitor rapamycin or the general TOR inhibitor Torin1 confirmed that a reduction in TORC1 activity promoted recovery from BFA induced stress. Phosphorylation of Ppk32 on two residues that are conserved within the SCYL pseudo-kinase family are required for this TOR inhibition. Phosphorylation on these sites controls Ppk32 protein levels and sensitivity to BFA. BFA induced ER stress does not account for the response to BFA that we report here, however BFA is also known to induce Golgi stress and impair traffic to lysosomes. In summary, Ppk32 reduce TOR signalling in response to BFA induced stress to support cell survival. PMID:27191590

  20. 76 FR 61072 - Committees on Administration and Management, Collaborative Governance, Judicial Review, and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-03

    ... Governance, Judicial Review, and Regulation ACTION: Notice of public meetings. SUMMARY: Notice is hereby... Governance The Committee on Collaborative Governance will consider recommending improvements to the Federal... or improve the transparency of FACA committees. The Committee on Collaborative Governance may...

  1. Achieving Accelerated Cleanup of Cesium Contaminated Stream at the Savannah River Site; Collaboration between Stakeholders, Regulators, and the Federal Government - 13182

    SciTech Connect

    Bergren, Chris; Flora, Mary; Socha, Ron; Burch, Joseph; Freeman, Candice; Hennessey, Brian

    2013-07-01

    's stakeholders including the regulators, U. S. Environmental Protection Agency (US EPA) and the South Carolina Department of Health and Environmental Control (SCDHEC), and the public including local property owners and the SRS Citizens Advisory Board. Stakeholder buy-in was critical in the up-front planning in order to achieve this challenging cleanup. (authors)

  2. 50 CFR 216.105 - Specific regulations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS REGULATIONS GOVERNING THE TAKING AND IMPORTING OF MARINE MAMMALS General Regulations Governing Small Takes of Marine Mammals Incidental to Specified Activities... mammals by harassment, serious injury, death or a combination thereof, specific regulations shall...

  3. 50 CFR 216.105 - Specific regulations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS REGULATIONS GOVERNING THE TAKING AND IMPORTING OF MARINE MAMMALS General Regulations Governing Small Takes of Marine Mammals Incidental to Specified Activities... mammals by harassment, serious injury, death or a combination thereof, specific regulations shall...

  4. 50 CFR 216.105 - Specific regulations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS REGULATIONS GOVERNING THE TAKING AND IMPORTING OF MARINE MAMMALS General Regulations Governing Small Takes of Marine Mammals Incidental to Specified Activities... mammals by harassment, serious injury, death or a combination thereof, specific regulations shall...

  5. 50 CFR 216.105 - Specific regulations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS REGULATIONS GOVERNING THE TAKING AND IMPORTING OF MARINE MAMMALS General Regulations Governing Small Takes of Marine Mammals Incidental to Specified Activities... mammals by harassment, serious injury, death or a combination thereof, specific regulations shall...

  6. Do Kids Need Government Censors?

    ERIC Educational Resources Information Center

    Rabkin, Rhoda

    2002-01-01

    Fashioning public policies restricting children's access to entertainment glamorizing violence, sex, drugs, and vulgarity is a complex task. The recently introduced Media Marketing Accountability Act would empower the federal government to regulate advertising of entertainment products to youth. Suggests that this power is undesirable compared to…

  7. 41 CFR 102-34.215 - May Government contractors use Government motor vehicles?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION PERSONAL PROPERTY 34-MOTOR VEHICLE MANAGEMENT Official Use of Government Motor Vehicles § 102-34.215 May Government... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false May...

  8. 41 CFR 102-34.215 - May Government contractors use Government motor vehicles?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION PERSONAL PROPERTY 34-MOTOR VEHICLE MANAGEMENT Official Use of Government Motor Vehicles § 102-34.215 May Government... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false May...

  9. 41 CFR 102-34.215 - May Government contractors use Government motor vehicles?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION PERSONAL PROPERTY 34-MOTOR VEHICLE MANAGEMENT Official Use of Government Motor Vehicles § 102-34.215 May Government... 41 Public Contracts and Property Management 3 2013-07-01 2013-07-01 false May...

  10. Federal Powers of Regulation.

    ERIC Educational Resources Information Center

    Rhyne, William S.

    1979-01-01

    Reflects the special considerations in affecting, rather than merely evaluating, the outcome of constitutional litigation over federal regulation of state and local government labor relations. (Author/IRT)

  11. 48 CFR 852.236-78 - Government supervision.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Government supervision. 852.236-78 Section 852.236-78 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS... Government supervision. As prescribed in 836.572, insert the following clause: Government Supervision...

  12. 48 CFR 852.236-78 - Government supervision.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Government supervision. 852.236-78 Section 852.236-78 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS... Government supervision. As prescribed in 836.572, insert the following clause: Government Supervision...

  13. 48 CFR 852.236-78 - Government supervision.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Government supervision. 852.236-78 Section 852.236-78 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS... Government supervision. As prescribed in 836.572, insert the following clause: Government Supervision...

  14. 48 CFR 245.103-71 - Transferring Government property accountability.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Transferring Government... ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT GOVERNMENT PROPERTY General 245.103-71 Transferring Government property accountability. Follow the procedures at PGI 245.103-71...

  15. 48 CFR 852.236-78 - Government supervision.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Government supervision. 852.236-78 Section 852.236-78 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS... Government supervision. As prescribed in 836.572, insert the following clause: Government Supervision...

  16. 48 CFR 245.103-71 - Transferring Government property accountability.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Transferring Government... ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT GOVERNMENT PROPERTY General 245.103-71 Transferring Government property accountability. Follow the procedures at PGI 245.103-71...

  17. 48 CFR 852.236-78 - Government supervision.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Government supervision. 852.236-78 Section 852.236-78 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS... Government supervision. As prescribed in 836.572, insert the following clause: Government Supervision...

  18. 31 CFR 540.304 - Government of the Russian Federation.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Government of the Russian Federation...) AGREEMENT ASSETS CONTROL REGULATIONS General Definitions § 540.304 Government of the Russian Federation. (a) The term Government of the Russian Federation means the Government of the Russian Federation,...

  19. 31 CFR 540.304 - Government of the Russian Federation.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Government of the Russian Federation...) AGREEMENT ASSETS CONTROL REGULATIONS General Definitions § 540.304 Government of the Russian Federation. (a) The term Government of the Russian Federation means the Government of the Russian Federation,...

  20. 48 CFR 42.1304 - Government delay of work.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Government delay of work... CONTRACT MANAGEMENT CONTRACT ADMINISTRATION AND AUDIT SERVICES Suspension of Work, Stop-Work Orders, and Government Delay of Work 42.1304 Government delay of work. (a) The clause at 52.242-17, Government Delay...

  1. 48 CFR 252.241-7001 - Government access.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Government access. 252.241... Clauses 252.241-7001 Government access. As prescribed in 241.501-70(b), use the following clause: Government Access (DEC 1991) Authorized representatives of the Government may have access to the...

  2. 48 CFR 252.241-7001 - Government access.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Government access. 252.241... Clauses 252.241-7001 Government access. As prescribed in 241.501-70(b), use the following clause: Government Access (DEC 1991) Authorized representatives of the Government may have access to the...

  3. 48 CFR 252.227-7022 - Government rights (unlimited).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Government rights... of Provisions And Clauses 252.227-7022 Government rights (unlimited). As prescribed at 227.7107-1(a), use the following clause: Government Rights (Unlimited) (MAR 1979) The Government shall have...

  4. 48 CFR 52.251-1 - Government Supply Sources.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Government Supply Sources....251-1 Government Supply Sources. As prescribed in 51.107, insert the following clause in solicitations... services from a Government supply source: Government Supply Sources (AUG 2010) The Contracting Officer...

  5. 48 CFR 552.246-71 - Source Inspection by Government.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Government. 552.246-71 Section 552.246-71 Federal Acquisition Regulations System GENERAL SERVICES....246-71 Source Inspection by Government. As prescribed in 546.302-71, insert the following clause: Source Inspection by Government (JUNE 1, 2009) (a) Inspection by Government personnel. (1) Supplies to...

  6. 48 CFR 552.227-70 - Government Rights (Unlimited).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Government Rights....227-70 Government Rights (Unlimited). As prescribed in 527.409, insert the following clause: Government Rights (Unlimited) (MAY 1989) The Government shall have unlimited rights in all drawings,...

  7. 48 CFR 1552.237-76 - Government-Contractor Relations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Government-Contractor... 1552.237-76 Government-Contractor Relations. As prescribed in 1537.110(g), insert the following clause: Government-Contractor Relations (JUN 1999) (a) The Government and the Contractor understand and agree...

  8. 48 CFR 42.1304 - Government delay of work.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Government delay of work... CONTRACT MANAGEMENT CONTRACT ADMINISTRATION AND AUDIT SERVICES Suspension of Work, Stop-Work Orders, and Government Delay of Work 42.1304 Government delay of work. (a) The clause at 52.242-17, Government Delay...

  9. 48 CFR 42.1304 - Government delay of work.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Government delay of work... CONTRACT MANAGEMENT CONTRACT ADMINISTRATION AND AUDIT SERVICES Suspension of Work, Stop-Work Orders, and Government Delay of Work 42.1304 Government delay of work. (a) The clause at 52.242-17, Government Delay...

  10. 48 CFR 1952.227-76 - Government rights (unlimited).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Government rights... 1952.227-76 Government rights (unlimited). As prescribed in 1927.405(g), insert the following clause: Government Rights (Unlimited) (FEB 1985) The Government shall have unlimited rights, in all drawings,...

  11. 48 CFR 47.207-8 - Government responsibilities.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Government....207-8 Government responsibilities. (a) The contracting officer shall state clearly the Government's... Government's responsibility to notify the contractor in advance when hazardous materials are included in...

  12. 48 CFR 1952.227-76 - Government rights (unlimited).

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Government rights... 1952.227-76 Government rights (unlimited). As prescribed in 1927.405(g), insert the following clause: Government Rights (Unlimited) (FEB 1985) The Government shall have unlimited rights, in all drawings,...

  13. 48 CFR 252.241-7001 - Government access.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Government access. 252.241... Clauses 252.241-7001 Government access. As prescribed in 241.501-70(b), use the following clause: Government Access (DEC 1991) Authorized representatives of the Government may have access to the...

  14. 48 CFR 52.251-1 - Government Supply Sources.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 2 2014-10-01 2014-10-01 false Government Supply Sources....251-1 Government Supply Sources. As prescribed in 51.107, insert the following clause: Government... Government supply sources in the performance of this contract. Title to all property acquired by...

  15. 48 CFR 252.241-7001 - Government access.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Government access. 252.241... Clauses 252.241-7001 Government access. As prescribed in 241.501-70(b), use the following clause: Government Access (DEC 1991) Authorized representatives of the Government may have access to the...

  16. 48 CFR 252.241-7001 - Government access.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Government access. 252.241... Clauses 252.241-7001 Government access. As prescribed in 241.501-70(b), use the following clause: Government Access (DEC 1991) Authorized representatives of the Government may have access to the...

  17. 48 CFR 47.207-8 - Government responsibilities.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Government....207-8 Government responsibilities. (a) The contracting officer shall state clearly the Government's... Government's responsibility to notify the contractor in advance when hazardous materials are included in...

  18. 48 CFR 47.207-8 - Government responsibilities.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Government....207-8 Government responsibilities. (a) The contracting officer shall state clearly the Government's... Government's responsibility to notify the contractor in advance when hazardous materials are included in...

  19. 48 CFR 2845.505-14 - Report of Government Property.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Report of Government... CONTRACT MANAGEMENT GOVERNMENT PROPERTY Management of Government Property in the Possession of Contractors 2845.505-14 Report of Government Property. (a) In compliance with FAR 45.505-14, by January 31 of...

  20. 48 CFR 832.202-4 - Security for Government financing.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Security for Government... for Government financing. An offeror's financial condition may be considered adequate security to protect the Government's interest when the Government provides contract financing. In assessing...

  1. 48 CFR 2452.227-70 - Government information.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Government information... 2452.227-70 Government information. As prescribed in 2427.470, use the following clause: Government Information (DEC 2012) (a) Definitions. As used in this clause, “Government information” includes—...

  2. 48 CFR 552.227-70 - Government Rights (Unlimited).

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 4 2013-10-01 2013-10-01 false Government Rights....227-70 Government Rights (Unlimited). As prescribed in 527.409, insert the following clause: Government Rights (Unlimited) (MAY 1989) The Government shall have unlimited rights in all drawings,...

  3. 48 CFR 2945.105 - Records of Government property.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 7 2014-10-01 2014-10-01 false Records of Government... MANAGEMENT GOVERNMENT PROPERTY General 2945.105 Records of Government property. Contracting officers must maintain a file on any Government-furnished property (GFP) in the possession of contractors. As a...

  4. 48 CFR 47.207-8 - Government responsibilities.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Government....207-8 Government responsibilities. (a) The contracting officer shall state clearly the Government's... Government's responsibility to notify the contractor in advance when hazardous materials are included in...

  5. 48 CFR 832.202-4 - Security for Government financing.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Security for Government... for Government financing. An offeror's financial condition may be considered adequate security to protect the Government's interest when the Government provides contract financing. In assessing...

  6. 31 CFR 537.307 - Government of Burma.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Government of Burma. 537.307 Section 537.307 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF....307 Government of Burma. The term Government of Burma means the Government of Burma...

  7. 48 CFR 2945.105 - Records of Government property.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 7 2011-10-01 2011-10-01 false Records of Government... MANAGEMENT GOVERNMENT PROPERTY General 2945.105 Records of Government property. Contracting officers must maintain a file on any Government-furnished property (GFP) in the possession of contractors. As a...

  8. 48 CFR 252.227-7022 - Government rights (unlimited).

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Government rights... of Provisions And Clauses 252.227-7022 Government rights (unlimited). As prescribed at 227.7107-1(a), use the following clause: Government Rights (Unlimited) (MAR 1979) The Government shall have...

  9. 48 CFR 52.251-1 - Government Supply Sources.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 2 2013-10-01 2013-10-01 false Government Supply Sources....251-1 Government Supply Sources. As prescribed in 51.107, insert the following clause: Government... Government supply sources in the performance of this contract. Title to all property acquired by...

  10. 48 CFR 942.705-4 - State and local governments.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... governments. 942.705-4 Section 942.705-4 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CONTRACT... governments. A list of cognizant agencies for State/local government organizations is periodically published... notified of such assignments. The current negotiated rates for State/local government activities...

  11. 48 CFR 225.7402-3 - Government support.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Government support. 225... States 225.7402-3 Government support. (a) Government support that may be authorized or required for... coordination with the combatant commander that— (1) Such Government support is available and is needed...

  12. 48 CFR 1552.237-76 - Government-Contractor Relations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Government-Contractor... 1552.237-76 Government-Contractor Relations. As prescribed in 1537.110(g), insert the following clause: Government-Contractor Relations (JUN 1999) (a) The Government and the Contractor understand and agree...

  13. 48 CFR 252.227-7022 - Government rights (unlimited).

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Government rights... of Provisions And Clauses 252.227-7022 Government rights (unlimited). As prescribed at 227.7107-1(a), use the following clause: Government Rights (Unlimited) (MAR 1979) The Government shall have...

  14. 48 CFR 225.7402-3 - Government support.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Government support. 225... States 225.7402-3 Government support. (a) Government support that may be authorized or required for... coordination with the combatant commander that— (1) Such Government support is available and is needed...

  15. 48 CFR 2845.105 - Records of Government property.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Records of Government... MANAGEMENT GOVERNMENT PROPERTY General 2845.105 Records of Government property. If departmental elements maintain the Government's official property management records, the contract records may be kept as...

  16. 31 CFR 537.307 - Government of Burma.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Government of Burma. 537.307 Section 537.307 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF....307 Government of Burma. The term Government of Burma means the Government of Burma...

  17. 48 CFR 252.227-7022 - Government rights (unlimited).

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Government rights... of Provisions And Clauses 252.227-7022 Government rights (unlimited). As prescribed at 227.7107-1(a), use the following clause: Government Rights (Unlimited) (MAR 1979) The Government shall have...

  18. 31 CFR 537.307 - Government of Burma.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Government of Burma. 537.307 Section 537.307 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF....307 Government of Burma. The term Government of Burma means the Government of Burma...

  19. 48 CFR 832.202-4 - Security for Government financing.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Security for Government... for Government financing. An offeror's financial condition may be considered adequate security to protect the Government's interest when the Government provides contract financing. In assessing...

  20. 48 CFR 2452.227-70 - Government information.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Government information... 2452.227-70 Government information. As prescribed in 2427.470, use the following clause: Government Information (DEC 2012) (a) Definitions. As used in this clause, “Government information” includes—...

  1. 48 CFR 552.227-70 - Government Rights (Unlimited).

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 4 2012-10-01 2012-10-01 false Government Rights....227-70 Government Rights (Unlimited). As prescribed in 527.409, insert the following clause: Government Rights (Unlimited) (MAY 1989) The Government shall have unlimited rights in all drawings,...

  2. 48 CFR 832.202-4 - Security for Government financing.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Security for Government... for Government financing. An offeror's financial condition may be considered adequate security to protect the Government's interest when the Government provides contract financing. In assessing...

  3. 48 CFR 552.246-71 - Source Inspection by Government.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Government. 552.246-71 Section 552.246-71 Federal Acquisition Regulations System GENERAL SERVICES....246-71 Source Inspection by Government. As prescribed in 546.302-71, insert the following clause: Source Inspection by Government (JUNE 1, 2009) (a) Inspection by Government personnel. (1) Supplies to...

  4. 48 CFR 552.246-71 - Source Inspection by Government.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Government. 552.246-71 Section 552.246-71 Federal Acquisition Regulations System GENERAL SERVICES....246-71 Source Inspection by Government. As prescribed in 546.302-71, insert the following clause: Source Inspection by Government (JUN 2009) (a) Inspection by Government personnel. (1) Supplies to...

  5. 31 CFR 537.307 - Government of Burma.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Government of Burma. 537.307 Section 537.307 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF....307 Government of Burma. The term Government of Burma means the Government of Burma (also known...

  6. 48 CFR 47.207-8 - Government responsibilities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Government....207-8 Government responsibilities. (a) The contracting officer shall state clearly the Government's... Government's responsibility to notify the contractor in advance when hazardous materials are included in...

  7. 48 CFR 225.7402-3 - Government support.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Government support. 225... States 225.7402-3 Government support. (a) Government support that may be authorized or required for... coordination with the combatant commander that— (1) Such Government support is available and is needed...

  8. 48 CFR 225.7402-3 - Government support.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Government support. 225... States 225.7402-3 Government support. (a) Government support that may be authorized or required for... coordination with the combatant commander that— (1) Such Government support is available and is needed...

  9. 48 CFR 2945.105 - Records of Government property.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Records of Government... MANAGEMENT GOVERNMENT PROPERTY General 2945.105 Records of Government property. Contracting officers must maintain a file on any Government-furnished property (GFP) in the possession of contractors. As a...

  10. 48 CFR 552.227-70 - Government Rights (Unlimited).

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 4 2014-10-01 2014-10-01 false Government Rights....227-70 Government Rights (Unlimited). As prescribed in 527.409, insert the following clause: Government Rights (Unlimited) (MAY 1989) The Government shall have unlimited rights in all drawings,...

  11. 48 CFR 942.705-4 - State and local governments.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... governments. 942.705-4 Section 942.705-4 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CONTRACT... governments. A list of cognizant agencies for State/local government organizations is periodically published... notified of such assignments. The current negotiated rates for State/local government activities...

  12. 48 CFR 942.705-4 - State and local governments.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... governments. 942.705-4 Section 942.705-4 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CONTRACT... governments. A list of cognizant agencies for State/local government organizations is periodically published... notified of such assignments. The current negotiated rates for State/local government activities...

  13. 48 CFR 225.7402-3 - Government support.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Government support. 225... States 225.7402-3 Government support. (a) Government support that may be authorized or required for... coordination with the combatant commander that— (1) Such Government support is available and is needed...

  14. 31 CFR 540.304 - Government of the Russian Federation.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Government of the Russian Federation...) AGREEMENT ASSETS CONTROL REGULATIONS General Definitions § 540.304 Government of the Russian Federation. (a) The term Government of the Russian Federation means the Government of the Russian Federation,...

  15. 31 CFR 540.304 - Government of the Russian Federation.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Government of the Russian Federation...) AGREEMENT ASSETS CONTROL REGULATIONS General Definitions § 540.304 Government of the Russian Federation. (a) The term Government of the Russian Federation means the Government of the Russian Federation,...

  16. 31 CFR 540.304 - Government of the Russian Federation.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Government of the Russian Federation...) AGREEMENT ASSETS CONTROL REGULATIONS General Definitions § 540.304 Government of the Russian Federation. (a) The term Government of the Russian Federation means the Government of the Russian Federation,...

  17. 10 CFR 603.220 - Government participation.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Government participation. 603.220 Section 603.220 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS TECHNOLOGY INVESTMENT AGREEMENTS Appropriate Use of... revisions of plans for future effort....

  18. 78 FR 44459 - Tribal Self-Governance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-24

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service 42 CFR Part 137 Tribal Self-Governance CFR Correction In Title 42 of the Code of Federal Regulations, Parts 1 to 399, revised as of October 1, 2012, on page 932,...

  19. 12 CFR 404.22 - Government contracts.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... section shall contain the standard contract clauses required by the Federal Acquisition Regulation (48 CFR... 12 Banks and Banking 5 2013-01-01 2013-01-01 false Government contracts. 404.22 Section 404.22... the Privacy Act of 1974 § 404.22 Government contracts. (a) Approval by Assistant General Counsel...

  20. 12 CFR 404.22 - Government contracts.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... section shall contain the standard contract clauses required by the Federal Acquisition Regulation (48 CFR... 12 Banks and Banking 5 2014-01-01 2014-01-01 false Government contracts. 404.22 Section 404.22... the Privacy Act of 1974 § 404.22 Government contracts. (a) Approval by Assistant General Counsel...

  1. 12 CFR 404.22 - Government contracts.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... section shall contain the standard contract clauses required by the Federal Acquisition Regulation (48 CFR... 12 Banks and Banking 5 2012-01-01 2012-01-01 false Government contracts. 404.22 Section 404.22... the Privacy Act of 1974 § 404.22 Government contracts. (a) Approval by Assistant General Counsel...

  2. 12 CFR 404.22 - Government contracts.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... section shall contain the standard contract clauses required by the Federal Acquisition Regulation (48 CFR... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Government contracts. 404.22 Section 404.22... the Privacy Act of 1974 § 404.22 Government contracts. (a) Approval by Assistant General Counsel...

  3. 12 CFR 404.22 - Government contracts.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... section shall contain the standard contract clauses required by the Federal Acquisition Regulation (48 CFR... 12 Banks and Banking 4 2011-01-01 2011-01-01 false Government contracts. 404.22 Section 404.22... the Privacy Act of 1974 § 404.22 Government contracts. (a) Approval by Assistant General Counsel...

  4. 48 CFR 32.202-4 - Security for Government financing.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Security for Government financing. 32.202-4 Section 32.202-4 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION... for Government financing. (a) Policy. (1) 10 U.S.C. 2307(f) and 41 U.S.C. 255(f) require...

  5. 48 CFR 35.014 - Government property and title.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Government property and title. 35.014 Section 35.014 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 35.014 Government property and title. (a) The requirements in part 45...

  6. 48 CFR 47.104-1 - Government rate tender procedures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Government rate tender procedures. 47.104-1 Section 47.104-1 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TRANSPORTATION General 47.104-1 Government rate tender procedures. (a) 49 U.S.C....

  7. 48 CFR 35.014 - Government property and title.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Government property and title. 35.014 Section 35.014 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 35.014 Government property and title. (a) The requirements in part 45...

  8. A COMPARATIVE ANALYSIS BETWEEN FRANCE AND JAPAN ON LOCAL GOVERNMENTS' INVOLVEMENT IN NUCLEAR SAFETY GOVERNANCE

    NASA Astrophysics Data System (ADS)

    Sugawara, Shin-Etsu; Shiroyama, Hideaki

    This paper shows a comparative analysis between France and Japan on the way of the local governments' involvement in nuclear safety governance through some interviews. In France, a law came into force that requires related local governments to establish "Commision Locale d'Information" (CLI), which means the local governments officially involve in nuclear regulatory activity. Meanwhile, in Japan, related local governments substantially involve in the operation of nuclear facilities through the "safety agreements" in spite of the lack of legal authority. As a result of comparative analysis, we can point out some institutional input from French cases as follows: to clarify the local governments' roles in the nuclear regulation system, to establish the official channels of communication among nuclear utilities, national regulatory authorities and local governments, and to stipulate explicitly the transparency as a purpose of safety regulation.

  9. The Right to Regulate

    NASA Technical Reports Server (NTRS)

    Vittek, J. F.

    1972-01-01

    An introduction to the historical and constitutional framework of industry regulation by local and Federal Governments is presented. Problems of the confiscation of private property without due process, government control and the rights and duties of the regulated industry are discussed.

  10. Conforming Amendments to the Regulations Governing Nondiscrimination on the Basis of Race, Color, National, Origin, Disability, Sex, and Age under the Civil Rights Restoration Act of 1987; Final Rule. Federal Register, Part IV: Department of Education, 34 CFR Parts 100, 104, 106, and 110.

    ERIC Educational Resources Information Center

    Federal Register, 2000

    2000-01-01

    The Secretary amends the regulations governing nondiscrimination on the basis of race, color, national origin, sex, handicap, and age to conform with statutory amendments made by the Civil Rights Restoration Act of 1987 (CRRA). These amendments add a definition of "program or activity" or "program" that adopts the statutory definition of "program…

  11. Leisure, Government and Governance: A Swedish Perspective

    ERIC Educational Resources Information Center

    Lindstrom, Lisbeth

    2011-01-01

    The leisure sector has witnessed a tremendous expansion since 1960. The purpose of this article is to analyse the decisions and goals of Swedish government policy during the period 1962 to 2005. The empirical analysis covers government Propositions and governmental investigations. The fields covered are sports, culture, exercise, tourism and…

  12. 76 FR 2001 - Government Property

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-12

    ...NASA is issuing a final rule to revise the NASA FAR Supplement (NFS) to update Agency-level, property-related provisions, clauses, prescriptions and procedures to be consistent with changes made to Part 45 and Part 52.245 of the Federal Acquisition Regulation in Federal Acquisition Circular (FAC) 2005-17. FAC 2005-17 significantly rewrote FAR Part 45, Government Property, and changed property......

  13. 48 CFR 846.408 - Single-agency assignments of Government contract quality assurance.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... of Government contract quality assurance. 846.408 Section 846.408 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS CONTRACT MANAGEMENT QUALITY ASSURANCE Government Contract Quality Assurance 846.408 Single-agency assignments of Government contract quality assurance....

  14. Clinical governance and pathology

    PubMed Central

    Crook, M

    2002-01-01

    This article looks at clinical governance and pathology. Clinical governance should be an important tool in seeking quality improvement within the Natinal Health Service. But how as pathologists should we go about it? PMID:11896066

  15. LACC Shared Governance Model.

    ERIC Educational Resources Information Center

    Spangler, Mary

    This document discusses Los Angeles City College's (LACC) (California) Shared Governance Model. In response to California Assembly Bill 1725, LACC set forth a plan to implement the statutory requirements of shared governance. Shared governance is a concept grounded in the idea that decision-making is a process that affects the entire campus…

  16. Teaching about Comparative Government

    ERIC Educational Resources Information Center

    Risinger, C. Frederick

    2009-01-01

    As international relationships become increasingly important (with both friendly and not-so-friendly governments), the author believes that it is important for U.S. students to learn about how a parliamentary democracy works--how it is similar, but different from a presidential-style government. Learning about the systems of government of other…

  17. Taking Student Government Seriously.

    ERIC Educational Resources Information Center

    Bolen, J. R.

    1999-01-01

    Discusses the student government at La Mesa Middle School (California) that was modeled after the three-branch U.S. government as a means for increasing students' civic understanding. Describes the structure of the legislative, judicial, and executive branches, the different activities of the student government, and the reasons for the hiatus.…

  18. Modelling University Governance

    ERIC Educational Resources Information Center

    Trakman, Leon

    2008-01-01

    Twentieth century governance models used in public universities are subject to increasing doubt across the English-speaking world. Governments question if public universities are being efficiently governed; if their boards of trustees are adequately fulfilling their trust obligations towards multiple stakeholders; and if collegial models of…

  19. Governance in Strategic Context

    ERIC Educational Resources Information Center

    Alfred, Richard L.

    2008-01-01

    This chapter begins with a retrospective look at governance in community colleges based on a working understanding of governance as a correlate of decision making. In its simplest form, governance is "a process for distributing authority, power, and influence in decision making among constituencies" (Alfred and Smydra, 1985, pp. 201-202). What…

  20. Wyoming Government, Unit VII.

    ERIC Educational Resources Information Center

    Robinson, Terry

    This unit on Wyoming government presents concepts, activities, and stories for elementary school students. Concepts stress that the functions of government are determined according to the demands, needs, and traditions of the people; each part of government has a special function; as citizens, we should be loyal to the underlying concepts of our…

  1. 48 CFR 436.203 - Government estimate of construction costs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Government estimate of... Contracting for Construction 436.203 Government estimate of construction costs. For acquisitions using sealed bid procedures, the contracting officer may disclose the overall amount of the Government's...

  2. 48 CFR 236.203 - Government estimate of construction costs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Government estimate of...-ENGINEER CONTRACTS Special Aspects of Contracting for Construction 236.203 Government estimate of construction costs. Follow the procedures at PGI 236.203 for handling the Government estimate of...

  3. 48 CFR 52.247-26 - Government Direction and Marking.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 2 2011-10-01 2011-10-01 false Government Direction and....247-26 Government Direction and Marking. As prescribed in 47.207-8(a)(3), insert the following clause... relocations are involved: Government Direction and Marking (APR 1984) The agency being relocated shall tag...

  4. 48 CFR 52.247-26 - Government Direction and Marking.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Government Direction and....247-26 Government Direction and Marking. As prescribed in 47.207-8(a)(3), insert the following clause... relocations are involved: Government Direction and Marking (APR 1984) The agency being relocated shall tag...

  5. 31 CFR 576.310 - Government of Iraq.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Government of Iraq. 576.310 Section... FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY IRAQ STABILIZATION AND INSURGENCY SANCTIONS REGULATIONS General Definitions § 576.310 Government of Iraq. The term Government of Iraq means: (a) Any interim...

  6. 31 CFR 576.310 - Government of Iraq.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Government of Iraq. 576.310 Section... FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY IRAQ STABILIZATION AND INSURGENCY SANCTIONS REGULATIONS General Definitions § 576.310 Government of Iraq. The term Government of Iraq means: (a) Any interim...

  7. 31 CFR 576.310 - Government of Iraq.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Government of Iraq. 576.310 Section... FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY IRAQ STABILIZATION AND INSURGENCY SANCTIONS REGULATIONS General Definitions § 576.310 Government of Iraq. The term Government of Iraq means: (a) Any interim...

  8. 31 CFR 576.310 - Government of Iraq.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Government of Iraq. 576.310 Section... FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY IRAQ STABILIZATION AND INSURGENCY SANCTIONS REGULATIONS General Definitions § 576.310 Government of Iraq. The term Government of Iraq means: (a) Any interim...

  9. 48 CFR 52.242-17 - Government Delay of Work.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Government Delay of Work....242-17 Government Delay of Work. As prescribed in 42.1305(c), insert the following clause in... services, or for supplies that are commercial or modified-commercial items. Government Delay of Work...

  10. 48 CFR 49.109-3 - Government property.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Government property. 49... MANAGEMENT TERMINATION OF CONTRACTS General Principles 49.109-3 Government property. Before execution of a settlement agreement, the TCO shall determine the accuracy of the Government property account for...

  11. 48 CFR 49.109-3 - Government property.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Government property. 49... MANAGEMENT TERMINATION OF CONTRACTS General Principles 49.109-3 Government property. Before execution of a settlement agreement, the TCO shall determine the accuracy of the Government property account for...

  12. 48 CFR 49.109-3 - Government property.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Government property. 49... MANAGEMENT TERMINATION OF CONTRACTS General Principles 49.109-3 Government property. Before execution of a settlement agreement, the TCO shall determine the accuracy of the Government property account for...

  13. 48 CFR 1545.107 - Government property clauses.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... defined in Federal Standard No. 313, or, the toxic chemicals listed 40 CFR 372.65, in the environment. (2... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Government property... CONTRACT MANAGEMENT GOVERNMENT PROPERTY General 1545.107 Government property clauses. (a) The...

  14. 48 CFR 1552.245-71 - Government-furnished data.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Government-furnished data... Government-furnished data. As prescribed in 1545.107(b), insert the following contract clause in any contract that the Government is to furnish the Contractor data. Identify in the clause the data to be...

  15. 48 CFR 1552.245-71 - Government-furnished data.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Government-furnished data... Government-furnished data. As prescribed in 1545.107(b), insert the following contract clause in any contract that the Government is to furnish the Contractor data. Identify in the clause the data to be...

  16. 48 CFR 1552.245-71 - Government-furnished data.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Government-furnished data... Government-furnished data. As prescribed in 1545.107(b), insert the following contract clause in any contract that the Government is to furnish the Contractor data. Identify in the clause the data to be...

  17. 48 CFR 252.239-7013 - Obligation of the Government.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Government. 252.239-7013 Section 252.239-7013 Federal Acquisition Regulations System DEFENSE ACQUISITION... of Provisions And Clauses 252.239-7013 Obligation of the Government. As prescribed in 239.7411(c), use the following clause: Obligation of the Government (JUL 2006) (a) This basic agreement is not...

  18. 48 CFR 1252.245-70 - Government property reports.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ....245-70 Government property reports. As prescribed in (TAR) 48 CFR 1245.505-70, insert the following clause: Government Property Reports (OCT 1994) (a) The Contractor shall prepare an annual report of... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Government...

  19. 48 CFR 3052.245-70 - Government property reports.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... (HSAR) 48 CFR 3045.505-70, insert the following clause: Government Property Reports (JUN 2006) (a) The... calendar year on DHS Form 0700-5, Contractor Report of Government Property. (End of clause) ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Government...

  20. 4 CFR 25.1 - Applicability and governing laws.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 4 Accounts 1 2010-01-01 2010-01-01 false Applicability and governing laws. 25.1 Section 25.1... OFFICE BUILDING AND ON ITS GROUNDS § 25.1 Applicability and governing laws. These rules and regulations, and the laws of the United States and the District of Columbia, apply to the Government...