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Sample records for grifola frondosa solving

  1. Isolation, purification and antioxidant activities of polysaccharides from Grifola frondosa.

    PubMed

    Chen, Gui-tang; Ma, Xue-mei; Liu, Sheng-to; Liao, Yan-li; Zhao, Guo-qang

    2012-06-01

    The crude polysaccharides (GFP) were isolated from the fruiting bodies of Grifola frondosa and purified by DEAE cellulose-52 chromatography and Sephadex G-100 size-exclusion chromatography in that order. Three main fractions, GFP-1, GFP-2 and GFP-3, were obtained through the isolation and purification steps. Then the antioxidant activities of these three fractions were investigated in vitro. The results showed that GFP-1, GFP-2 and GFP-3 possessed significant inhibitory effects on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, hydroxyl radical and superoxide radical; their reducing power, ferrous ions chelating effect and the inhibition ability of the rat liver lipid oxidation where also strong. These results suggest that G. frondosa polysaccharides could be a suitable natural antioxidant and may be the functional foods for humans. PMID:24750604

  2. Immunomodulatory activity of macromolecular polysaccharide isolated from Grifola frondosa.

    PubMed

    Ma, Xiao-Lei; Meng, Meng; Han, Li-Rong; Li, Zheng; Cao, Xiao-Hong; Wang, Chun-Ling

    2015-12-01

    The present study was designed to evaluate the immune-modulating effects of the polysaccharide from Grifola frondosa (GFP) by using mouse peritoneal macrophage and cytoxan (CTX) induced immunosuppression models. Our results from the phagocytotic and mononuclear phagocytic system function assays showed that GFP-A (one component from GFP) stimulated the phagocytosis of the phagocytes. The splenocyte proliferation assay showed that GFP-A acted the effect combing ConA or LPS in splenocyte proliferation. The results showed that GFP-A increased indices of thymus and spleen, the levels of LDH and ACP in the spleen, the mRNA levels of IL-1β, IL-2, IL-6 and IFN-γ in splenocyte. And GFP-A also significantly increased the expression of CD4(+) and CD8(+) splenic T lymphocytes, which were suppressed by the CTX in peripheral blood. In conclusion, our results indicate that the GFP-A is involved in immunomodulatory effects leading to its modulatory effects on immunosuppression. PMID:26721709

  3. Antioxidant properties and antioxidant compounds of various extracts from the edible basidiomycete Grifola frondosa (Maitake).

    PubMed

    Yeh, Jan-Ying; Hsieh, Li-Hui; Wu, Kaun-Tzer; Tsai, Cheng-Fang

    2011-01-01

    Grifola frondosa is an edible mushroom currently available in Taiwan. Ethanolic, cold-water and hot-water extracts were prepared and their antioxidant properties were investigated. At 1 mg/mL, G. frondosa T1 and T2 cold-water extracts showed high reducing powers of 1.02 and 0.50, respectively. Chelating abilities on ferrous ions of G. frondosa T1 and T2 were higher for cold-water extracts than for ethanolic and hot-water extracts. For the scavenging ability on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, G. frondosa T1 and T2 extracts were effective in the following order: ethanolic > hot-water > cold-water. The G. frondosa hot-water extract showed high scavenging ability on superoxide anions. Total phenols, flavonoids, ascorbic acid and α-tocopherol are the major antioxidant components found in the various G. frondosa extracts. Based on EC(50) values (<20 mg/mL) obtained, the various extracts from G. frondosa investigated in this study display potent antioxidative properties. PMID:21499220

  4. The Mechanisms Underlying the Hypolipidaemic Effects of Grifola frondosa in the Liver of Rats.

    PubMed

    Ding, Yinrun; Xiao, Chun; Wu, Qingping; Xie, Yizhen; Li, Xiangmin; Hu, Huiping; Li, Liangqiu

    2016-01-01

    The present study investigated the hypolipidaemic effects of Grifola frondosa and its regulation mechanism involved in lipid metabolism in liver of rats fed a high-cholesterol diet. The body weights and serum lipid levels of control rats, of hyperlipidaemic rats, and of hyperlipidaemic rats treated with oral G. frondosa were determined. mRNA expression and concentration of key lipid metabolism enzymes were investigated. Serum cholesterol, triacylglycerol, and low-density lipoprotein cholesterol levels were markedly decreased in hyperlipidaemic rats treated with G. frondosa compared with untreated hyperlipidaemic rats. mRNA expression of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), acyl-coenzyme A: cholesterol acyltransferase (ACAT2), apolipoprotein B (ApoB), fatty acid synthase (FAS), and acetyl-CoA carboxylase (ACC1) were significantly down-regulated, while expression of cholesterol 7-alpha-hydroxylase (CYP7A1) was significantly up-regulated in the livers of treated rats compared with untreated hyperlipidaemic rats. The concentrations of these enzymes also paralleled the observed changes in mRNA expression. Two-dimensional polyacrylamide gel electrophoresis (2-DE) and Matrix-Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry (MALDI-TOF-MS) were used to identify 20 proteins differentially expressed in livers of rats treated with G. frondosa compared with untreated hyperlipidemic rats. Of these 20 proteins, seven proteins were down-regulated, and 13 proteins were up-regulated. These findings indicate that the hypolipidaemic effects of G. frondosa reflected its modulation of key enzymes involved in cholesterol and triacylglycerol biosynthesis, absorption, and catabolic pathways. G. frondosa may exert anti-atherosclerotic effects by inhibiting LDL oxidation through down-regulation and up-regulating proteins expression in the liver of rats. Therefore, G. frondosa may produce both hypolipidaemic and anti-atherosclerotic effects, and potentially

  5. The Mechanisms Underlying the Hypolipidaemic Effects of Grifola frondosa in the Liver of Rats

    PubMed Central

    Ding, Yinrun; Xiao, Chun; Wu, Qingping; Xie, Yizhen; Li, Xiangmin; Hu, Huiping; Li, Liangqiu

    2016-01-01

    The present study investigated the hypolipidaemic effects of Grifola frondosa and its regulation mechanism involved in lipid metabolism in liver of rats fed a high-cholesterol diet. The body weights and serum lipid levels of control rats, of hyperlipidaemic rats, and of hyperlipidaemic rats treated with oral G. frondosa were determined. mRNA expression and concentration of key lipid metabolism enzymes were investigated. Serum cholesterol, triacylglycerol, and low-density lipoprotein cholesterol levels were markedly decreased in hyperlipidaemic rats treated with G. frondosa compared with untreated hyperlipidaemic rats. mRNA expression of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), acyl-coenzyme A: cholesterol acyltransferase (ACAT2), apolipoprotein B (ApoB), fatty acid synthase (FAS), and acetyl-CoA carboxylase (ACC1) were significantly down-regulated, while expression of cholesterol 7-alpha-hydroxylase (CYP7A1) was significantly up-regulated in the livers of treated rats compared with untreated hyperlipidaemic rats. The concentrations of these enzymes also paralleled the observed changes in mRNA expression. Two-dimensional polyacrylamide gel electrophoresis (2-DE) and Matrix-Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry (MALDI-TOF-MS) were used to identify 20 proteins differentially expressed in livers of rats treated with G. frondosa compared with untreated hyperlipidemic rats. Of these 20 proteins, seven proteins were down-regulated, and 13 proteins were up-regulated. These findings indicate that the hypolipidaemic effects of G. frondosa reflected its modulation of key enzymes involved in cholesterol and triacylglycerol biosynthesis, absorption, and catabolic pathways. G. frondosa may exert anti-atherosclerotic effects by inhibiting LDL oxidation through down-regulation and up-regulating proteins expression in the liver of rats. Therefore, G. frondosa may produce both hypolipidaemic and anti-atherosclerotic effects, and potentially

  6. Biological activities of Fructus arctii fermented with the basidiomycete Grifola frondosa.

    PubMed

    Kim, Jin-Hwa; Bae, Jun-Tae; Song, Min-Hyeon; Lee, Geun-Su; Choe, Soo-Young; Pyo, Hyeong-Bae

    2010-12-01

    Fructus arctii extract containing phenolic glycosides was cultured with Grifola frondosa mycelia to produce β-glucosidase and its biological activities were studied. This β-glucosidase converted the glycosides (arctiin and caffeic acid derivatives) into aglycones (arctigenin and caffeic acid). Fermented Fructus arctii extract (G-FAE) with G. frondosa had antioxidant and 5-lipoxygenase inhibitory activities. The photoprotective potential of G-FAE was tested in human dermal fibroblasts (HDF) exposed to ultra-violet A (UVA). It was revealed that G-FAE had an inhibitory effect on human interstitial collagenase (matrix metalloproteinase, MMP-1) expression in UVA-irradiated HDF. The treatment of UVA-irradiated HDF with G-FAE resulted in a dose-dependent decrease in the expression level of MMP-1 mRNA. G-FAE also showed notable stimulation of collagen biosynthetic activity for fibroblasts. These diverse functionalities suggest that G-FAE could be a promising cosmetic ingredient. PMID:21191759

  7. Physical characteristics and antioxidant effect of polysaccharides extracted by boiling water and enzymolysis from Grifola frondosa.

    PubMed

    Fan, Yina; Wu, Xiangyang; Zhang, Min; Zhao, Ting; Zhou, Ye; Han, Liang; Yang, Liuqing

    2011-06-01

    Grifola frondosa has been widely consumed in China and other Asian countries. Recent studies on G. frondosa have focused on the activities of polysaccharides extracted by water, and the activities of polysaccharides extracted by enzymolysis have not been studied. In this work, the relationship between the physical properties and antioxidant activity of polysaccharides extracted from G. frondosa by boiling water and enzymolysis was studied. Five polysaccharide extracts from the fruit body of G. frondosa were prepared by different extracting methods including boiling water, single enzyme enzymolysis with three different single enzymes (cellulose, pectinase, and pancreatin), and combined enzyme enzymolysis (cellulose:pectinase:pancreatin; 2:2:1). Characteristics such as the viscosity, Mw, polysaccharide content, protein content, infrared spectra, and antioxidant activities of the extracts were evaluated. The highest antioxidant activity was exhibited by the extracts prepared by combined enzyme extraction. The correlation analysis between antioxidant activity and polysaccharide content, protein content, Mw or viscosity indicated that the Mw had a more important role in antioxidant activity. Overall, the results indicate that the combined enzyme polysaccharide extracts can be developed as a new potential natural antioxidant. PMID:21458482

  8. Growth, fruiting and lignocellulolytic enzyme production by the edible mushroom Grifola frondosa (maitake).

    PubMed

    Montoya, Sandra; Orrego, Carlos Eduardo; Levin, Laura

    2012-04-01

    Cultivation of specialty mushrooms on lignocellulosic wastes represents one of the most economical organic recycling processes. Compared with other cultivated mushrooms, very little is known about the nature of the lignocellulolytic enzymes produced by the edible and medicinal fungus Grifola frondosa, the parameters affecting their production, and enzyme activity profiles during different stages of the developmental cycle. In this work we investigated the enzymes that enable G. frondosa, to colonize and deconstruct two formulations based on industrial lignocellulosic by-products. G. frondosa degraded both substrates (oak-sawdust plus corn bran, and oak/corn bran supplemented with coffee spent-ground) decreasing 67 and 50% of their lignin content, along with 44 and 37% of the polysaccharides (hemicellulose and cellulose) respectively. 35.3% biological efficiency was obtained when using oak sawdust plus corn bran as substrate. Coffee spent-ground addition inhibited mushroom production, decreased growth, xylanase and cellulase activities. However, taking into account that G. frondosa successfully colonized this residue; this substrate formula might be considered for its growth and medicinal polysaccharide production. Although G. frondosa tested positive for Azure B plate degradation, a qualitative assay for lignin-peroxidase, attempts to detect this activity during solid state fermentation were unsuccessful. Enzyme activities peaked during colonization but declined drastically during fruiting body formation. Highest activities achieved were: endoglucanase 12.3, exoglucanase 16.2, β-glucosidase 2.3, endoxylanase 20.3, amylase 0.26, laccase 14.8 and Mn-peroxidase 7.4 U/g dry substrate. PMID:22805935

  9. Structural characterization and antiviral activity of a novel heteropolysaccharide isolated from Grifola frondosa against enterovirus 71.

    PubMed

    Zhao, Chao; Gao, Luying; Wang, Chunyang; Liu, Bin; Jin, Yu; Xing, Zheng

    2016-06-25

    A novel heteropolysaccharide from Grifola frondosa mycelia was extracted and purified using DEAE Sephadex A-50 and Sephadex G-200 chromatography. Fourier transform infrared (FT-IR) spectroscopy and nuclear magnetic resonance ((1)H NMR and (13)C NMR) spectroscopy were used to decipher the structure of the purified G. frondosa polysaccharide (GFP1). Chemical and spectral analysis revealed that GFP1, with an average molecular weight of 40.5kDa, possessed a 1,6-β-d-glucan backbone with a single 1,3-α-d-fucopyranosyl side-branching unit. Enterovirus 71 (EV71) is the causative pathogen of hand-foot-and-mouth disease. GFP1 was tested for its anti-EV71 activity in cultured cells, which showed that EV71 viral replication was blocked and viral VP1 protein expression and genomic RNA synthesis were suppressed. Moreover, GFP1 exhibited apoptotic and other activities by suppressing the EV71-induced caspase-3 cleavage and IκBα down regulation. Our results demonstrate that the novel G. frondosa polysaccharide has antiviral activity, which could be valuable as a potentially new anti-EV71 therapeutic compound. PMID:27083830

  10. [Experimental study on intervention effect of Grifola frondosa on nonalcoholic steatohepatitis].

    PubMed

    Dai, Xian-wei; Chen, Zhi-yun; Yan, Mao-xiang; He, Bei-hui

    2015-05-01

    To study the preventive effect of Grifola frondosa on nonalcoholic steatohepatitis (NASH). The rat model of NASH was established by feeding high-fat diets for 12 weeks and intervened with 0.5 g · kg(-1) · d(-1) and 1.0 g · kg(-1) · d(-1) of C. frondosa powder suspensions. The degrees of hepatocyte fatty degeneration and inflammation were observed under the optical microscope with routine HE staining. The NAFLD activity scores (NAS) were calculated. Serum ALT, AST and hepatic TG and CHOL were tested by the biochemical method. The hepatic MDA was examined by thiobarbituric acid method. The hepatic SOD was tested by the xanthine oxidase test. The hepatic GSH-PX activity was determined by the dithio-nitrobenzoic acid method. Hepatic TNF-α and IL-6 were detected by the enzyme-linked immunosorbent assay (ELISA). The NASH model group induced by high-fat diets showed higher hepatic NAS, ser- um ALT, AST, CHOL and hepatic TG, CHOL, MDA, TNF-α, IL-6 (P < 0.01 or P < 0.05) and lower serum TG and hepatic SOD, GSH-PX (P < 0.01, P < 0.05) than the normal control group. After being intervened with different doses of G. frondosa, the NASH group revealed significantly lower hepatic NAS, serum ALT and hepatic TG, CHOL, MDA, TNF-α and IL-6 (P < 0.05) and higher hepatic SOD, GSH-PX (P < 0.05) than the model group. G. frondosa may prevent the further development of NASH by improving the disorder of lipid metabolism in rats with NASH induced by high-fat diets, relieving the level of oxidative stress and reducing the generation of inflammatory cytokines. PMID:26323153

  11. Lignin degradation, ligninolytic enzymes activities and exopolysaccharide production by Grifola frondosa strains cultivated on oak sawdust.

    PubMed

    Fernandes, Nona A; Isikhuemhen, Omoanghe S; Ohimain, Elijah I

    2011-07-01

    Fourteen strains of Grifola frondosa (Dicks.) S. F. Gray, originating from different regions (Asia, Europe and North America) were tested for lignin degradation, ligninolytic enzyme activities, protein accumulation and exopolysaccharide production during 55 days of cultivation on oak sawdust. Lignin degradation varied from 2.6 to7.1 % of dry weight of the oak sawdust substrate among tested strains. The loss of dry matter in all screened fungi varied between 11.7 and 33.0%, and the amount of crude protein in the dry substrate varied between 0.94 to 2.55%. The strain, MBFBL 596, had the highest laccase activity (703.3 U/l), and the maximum peroxidase activity of 22.6 U/l was shown by the strain MBFBL 684. Several tested strains (MBFBL 21, 638 and 662) appeared to be good producers of exopolysaccharides (3.5, 3.5 and 3.2 mg/ml respectively). PMID:24031728

  12. Immunomodulatory activities of medicinal mushroom Grifola frondosa extract and its bioactive constituent.

    PubMed

    Wu, Shu-Jing; Lu, Tzy-Ming; Lai, Min-Nan; Ng, Lean-Teik

    2013-01-01

    Grifola frondosa (GF), a high value medicinal mushroom in China and Japan, is popularly consumed as traditional medicines and health foods, especially for enhancing immune functions. In this study, our aim was to examine the immunomodulatory activities of GF and its bioactive compound ergosterol peroxide (EPO) in lipopolysaccharide (LPS)-induced human monocytic (THP-1) cells. At low concentrations, EPO but not other extracts showed a full protection against LPS-induced cell toxicity. EPO significantly blocked MyD88 and VCAM-1 expression, and cytokine (IL-1β, IL-6 and TNF-α) production in LPS-stimulated cells. It also effectively inhibited NF-κB activation, which was further confirmed with siRNA treatment. These results conclude that EPO may play an important role in the immunomodulatory activity of GF through inhibiting the production of pro-inflammatory mediators and activation of NF-κB signaling pathway. PMID:23336512

  13. Extraction, identification and antimicrobial activity of a new furanone, grifolaone A, from Grifola frondosa.

    PubMed

    He, Xiaoyun; Du, Xuezhu; Zang, Xiangyun; Dong, Lili; Gu, Zijian; Cao, Liping; Chen, Dafu; Keyhani, Nemat O; Yao, Lindan; Qiu, Junzhi; Guan, Xiong

    2016-04-01

    A furanone (1), (S)-methyl 2-(2-hydroxy-3,4-dimethyl-5-oxo-2,5-dihydrofuran-2-yl)acetate, was isolated from the edible mushroom Grifola frondosa. Mass spectrometry and NMR analyses were used to elucidate the structure of this compound, and its absolute configuration was determined using circular dichroism spectroscopy. Compound 1 exhibited specific antifungal activity against the plant pathogens, Fusarium oxysporum, Gibberella zeae and Piricularia oryzae and the opportunistic human pathogen, Pseudallescheria boydii, resulting in minimum inhibitory concentration values of 2.5, 2.5, 1.25 and 0.15 μg/mL, respectively. In contrast, the furanone showed only weak activity towards Aspergillus spp., Candida albicans and several other fungal strains tested as well as no appreciable antibacterial activity. PMID:26374926

  14. Optimization of subcritical water extraction of polysaccharides from Grifola frondosa using response surface methodology

    PubMed Central

    Yang, Liuqing; Qu, Hongyuan; Mao, Guanghua; Zhao, Ting; Li, Fang; Zhu, Bole; Zhang, Bingtao; Wu, Xiangyang

    2013-01-01

    Background: This research is among the few that has been conducted on the feasibility of subcritical water extraction (SWE) as a rapid and efficient extraction tool for polysaccharides. Objective: The aim of the study was to extractand optimize the parameter conditions of SWE of polysaccharides from Grifola frondosa using response surface methodology. Materials and Methods: In the study, SWEwas applied to extractbioactive compounds from G. frondosa. A preliminary analysis was made on the physical properties and content determination of extracts using SWE and hot water extraction (HWE). Analysis of the sample residues and antioxidant activities of the polysaccharides extracted by SWE and HWE were then evaluated. Results: The optimal extraction conditions include: extraction temperature of 210°C, extraction time of 43.65 min and the ratio of water to raw material of 26.15:1. Under these optimal conditions, the experimental yield of the polysaccharides (25.1 ± 0.3%) corresponded with the mean value predicted by the model and two times more than the mean value obtained by the traditional HWE. The antioxidant activities of polysaccharides extracted by SWE were generally higher than those extracted by HWE. From the study, the SWE technology could be a time-saving, high yield, and bioactive technique for production of polysaccharides. PMID:23772107

  15. Antitumor and immunomodulatory activity of a water-soluble polysaccharide from Grifola frondosa.

    PubMed

    Mao, Guang-Hua; Ren, Yi; Feng, Wei-Wei; Li, Qian; Wu, Hui-Yu; Jin, Dun; Zhao, Ting; Xu, Cai-Quan; Yang, Liu-Qing; Wu, Xiang-Yang

    2015-12-10

    Grifola frondosa has long been known and respected as a medically important fungus. This study investigated the characterization, antitumor and immunomodulatory activity of a polysaccharide named GP11 purified from G. frondosa. The results revealed that GP11 was composed of → 1)-D-Manp-(6 →,→ 1)-D-Glcp-(4 →,→ 1)-D-Galp-(6 → and → 2,3,6)-D-Glcp-(1 →, with branches attached at O-2,3 of 1,2,3,6-linked Glcp residues and terminal T-Glcp. GP11 exhibited indirect cytotoxic activity against HepG-2 cells in vitro, and it significantly inhibited the growth of Heps cells in vivo. GP11 increased the relative thymus and spleen weights as well as serum tumor necrosis factor-alpha and interleukin-2 levels. GP11 stimulated tumoricidal activity and the production of nitric oxide (NO), TNF-α and interleukin-1β, and it also stimulated the protein expression of iNOS and mRNA expression of iNOS and TNF-α. TLR-4 is a potential receptor for GP11-mediated macrophage activation. The results suggested that the antitumor activity of GP11 may be due to the improvement of immune functions through the TLR-4-mediated up-regulation of NO and TNF-α. PMID:26428141

  16. Decolorization of synthetic dyes and biodegradation of bisphenol a by laccase from the edible mushroom, Grifola frondosa.

    PubMed

    Nitheranont, Thitinard; Watanabe, Akira; Suzuki, Toshisada; Katayama, Takeshi; Asada, Yasuhiko

    2011-01-01

    A major laccase isozyme from Grifola frondosa (Lac 1) was found to be effective for decolorizing of synthetic dyes and degrading of bisphenol A. The oxidative capability of Lac 1 toward synthetic dyes and bisphenol A was enhanced in the presence of the redox mediator, 1-hydroxybenzotriazole. The major product from the degradation of bisphenol A by Lac 1 was determined to be 4-isopropenylphenol. PMID:21897011

  17. A polysaccharide from Grifola frondosa relieves insulin resistance of HepG2 cell by Akt-GSK-3 pathway.

    PubMed

    Ma, Xiaolei; Zhou, Fuchuan; Chen, Yuanyuan; Zhang, Yuanyuan; Hou, Lihua; Cao, Xiaohong; Wang, Chunling

    2014-07-01

    Grifola frondosa is an important fungal research resource. However, there was little report about hyperglycemic activity of Grifola frondosa polysaccharide on insulin resistance in vitro. In this study, the hypoglycemic activity of a polysaccharide obtained from Grifola frondosa (GFP) on HepG2 cell and hpyerglycemic mechanism were investigated. The purity of the isolated polysaccharides was examined by HPLC. In this research, it was found that GFP enhanced the absorption of glucose of HepG2 cells in a dose dependent manner at 24 h of 30 ugmL⁻¹. GC-MS and FT-IR spectroscopy analysis results showed that glucose and galactose were the dominant monosaccharides in GFP and the major component of GFP was β-pyranoside. Western-blotting results showed that the HepG2 cell model treated with GFP activated the insulin receptor protein (IRS) in the cell membrane and increased phosphorylated-AktSer473 expression, which had an inhibition of glycogen synthase kinase (GSK-3). The down-regulation of GSK-3 stimulated synthesis of intracellular glycogen. The results above suggested that the GFP increased the metabolism of glucose and stimulated synthesis of intracellular glycogen through the Akt/GSK-3 pathway. PMID:24908430

  18. Experimental analysis on the main contents of Rhizoma gastrodiae extract and inter-transformation throughout the fermentation process of Grifola frondosa.

    PubMed

    Wang, Na; Wu, Tian-xiang; Zhang, Yong; Xu, Xiao-bao; Tan, Sha; Fu, Hong-Wei

    2013-03-01

    Gastrodin (GA), p-hydroxylbenzaldehyde (HBA), p-hydroxybenzyl alcohol (gastrodigenin, HA) and parishin not only are the major active ingredients of Rhizoma gastrodiae, but exist transformed relations from each other throughout the fermentation process of Grifola frondosa in this work. We had found that parishin (non-free gastrodin) almost could completely transformed into gastrodin (GA, free gastrodin) after R. gastrodiae alcohol extract was sterilized by moist heat (121 °C, 30 min), but before was added into submerged cultivation of G. frondosa. However, interestingly and importantly, gastrodin re-synthesized of parishin after R. gastrodiae alcohol extract's addition into submerged cultivation of G. frondosa. In addition, the reduction of p-hydroxylbenzaldehyde and p-hydroxybenzyl alcohol in G. frondosa fermentation process reconfirmed that the G. frondosa strain 51616 really could synthesize gastrodin into parishin by submerged fermentation. This paper firstly also reported G. frondosa's effects on R. gastrodiae. PMID:23435908

  19. Extracellular laccase produced by an edible basidiomycetous mushroom, Grifola frondosa: purification and characterization.

    PubMed

    Nitheranont, Thitinard; Watanabe, Akira; Asada, Yasuhiko

    2011-01-01

    A major laccase isozyme (Lac 1) was isolated from the culture fluid of an edible basidiomycetous mushroom, Grifola frondosa. Lac 1 was revealed to be a monomeric protein with a molecular mass of 71 kDa. The N-terminal amino acid sequence of Lac 1 was highly similar to those of laccases of some other white-rot basidiomycetes. Lac 1 showed the typical absorption spectrum of a copper-containing enzyme. The enzyme was stable in a wide pH range (4.0 to 10.0), and lost no activity up to 60 °C for 60 min. The optimal pH of the enzyme activity varied among substrates. The K(m) values of Lac 1 toward 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid), 2,6-dimethoxyphenol, guaiacol, catechol, and 3,4-dihydroxy-L-phenylalanine were 0.0137 mM, 0.608 mM, 0.531 mM, 2.51 mM, and 0.149 mM respectively. Lac 1 activity was remarkably inhibited by the chloride ion, in a reversible manner. Lac 1 activity was also inhibited by thiol compounds. PMID:21389619

  20. [Role of the NO Synthase System in Response to Abiotic Stress Factors for Basidiomycetes Lentinula edodes and Grifola frondosa].

    PubMed

    Loshchinina, E A; Nikitina, V E

    2016-01-01

    Effect of stressors (unfavorable pH and temperature or carbon and nitrogen limitation) on the synthesis of the components of the NO synthase signaling system was studied in submerged cultures of xylotrophic basidiomycetes Lentinula edodes and Grifola frondosa. Marker compounds of the NO synthase signaling system were found in both cultures. A simultaneous increase of the concentrations of NO and citrulline in the culture liquid of the basidiomycetes grown at superoptimal pH and in nitrogen-limited medium indicates the activation of the NO synthase signaling system under such stress conditions. PMID:27476203

  1. A novel breeding strategy for new strains of Hypsizygus marmoreus and Grifola frondosa based on ligninolytic enzymes.

    PubMed

    Sun, Shujing; Li, Xiaojing; Ruan, Lingyun; Zhang, Liaoyuan; Hu, Kaihui

    2014-07-01

    A novel breeding strategy for new strains of Hypsizygus marmoreus and Grifola frondosa using ligninolytic enzymes as markers was evaluated with the detection and analysis of activities and composition of 15 edible fungi. The results showed that the activity and composition of ligninolytic enzyme system varied in response to changes of fungal strains. By analyzing the growth rate of mycelia and their ability to produce ligninolytic enzymes, H. marmoreus and P. geesteranus, G. frondosa and P. sajor-caju were screened for further study. Three colonies of 26 regenerated colonies of H. marmoreus and P. geesteranus protoplast fusion and one colony of 48 regenerated colonies of G. frondosa and P. sajor-caju were selected respectively. At the same time, these four strains were identified using RAPD and ISSR molecular markers. The results showed that the strains HM5G1 and PS7F1 are new strains and have low similarity to parental strains H. marmoreus and G. frondosa. These results are supported by the results of antagonism tests. These two fusants were significantly higher in their ligninolytic enzyme activity than H. marmoreus and G. frondosa. The growth rates of strains HM5G1and PS7F1 were also noticeably higher than those of H. marmoreus and G. frondosa, by 1.36 and 1.5 times respectively. The biological efficiency of the strain HM5G1 was 11.5% higher than that of the parental strain H. marmoreus. This work suggests that it is an efficient way of breeding new strains to use the decolorization of ligninolytic enzymes as a preliminary screening marker. PMID:24535613

  2. Effect of dietary Maitake (Grifola frondosa) mushrooms on plasma cholesterol and hepatic gene expression in cholesterol-fed mice.

    PubMed

    Sato, Mayumi; Tokuji, Yoshihiko; Yoneyama, Shozo; Fujii-Akiyama, Kyoko; Kinoshita, Mikio; Chiji, Hideyuki; Ohnishi, Masao

    2013-01-01

    To investigate the effects of dietary Grifola frondosa on cholesterol, normal mice were fed a diet containing 1% cholesterol (HC group) or 1% cholesterol and 10% freeze-dried G. frondosa powder (HC+G group) for 4 weeks and hepatic and plasma lipid levels were compared with those of a cholesterol-free diet-fed mice (N group). Hepatic total cholesterol (TC), triacylglycerol contents were considerably increased and plasma TC / phospholipid (PL) was also increased significantly in the HC group compared with the N group. However, plasma TC content decreased in the HC+G group compared with the HC group. To characterize the mechanisms responsible for lowered plasma cholesterol in G. frondosa-supplemented mice, hepatic gene expression was profiled using DNA microarray and gene ontology. Genome analyses revealed that de novo cholesterol synthesis genes were suppressed following cholesterol intake. However, expression of bile acid biosynthesis and low-density lipoprotein receptor genes showed little change. Scarb1, Abcg5, and Abcg8, involved in cholesterol transport and excretion, were slightly upregulated in the HC+G group compared with the HC group. These data indicate the plasma cholesterol-lowering effect of G. frondosa. Moreover, fatty acid (FA) β-oxidation was promoted via adipocytokine signaling pathways, and Saa, encodes serum amyloid A related to arteriosclerosis, was suppressed in the HC+G group. PMID:24292357

  3. Purification and characterization of a novel small-molecule polysaccharide from the Maitake medicinal mushroom Grifola frondosa (higher Basidiomycetes).

    PubMed

    Zhou, Changyan; Qiao, Yanru; Tang, Qingjiu; Jia, Wei; Liu, Yanfang; Wu, Aizhong

    2013-01-01

    A novel small-molecule polysaccharide with a molecular mass of 2.6 kDa, was isolated from the culinary-medicinal Maitake mushroom Grifola frondosa. GFPS is composed of fucose, rhamnose, galactose, glucose, and mannose; galactose, glucose, and mannose were the dominant monosaccharides. Absorption peaks at 1077 cm-1, 1024 cm-1, and 873 cm-1, as revealed by infrared spectrum, suggesting that GFPS consists of pyranoside. GFPS significantly enhanced the production of nitric oxide and secretion of cytokines (tumor necrosis factor-α, interleukin-1β, and interleukin-δ) from macrophages in vitro. These results indicate that this novel small-molecule polysaccharide might be beneficial for immune defense. PMID:23557366

  4. Functional polysaccharides from Grifola frondosa aqueous extract inhibit atopic dermatitis-like skin lesions in NC/Nga mice.

    PubMed

    Park, Hyeon Soo; Hwang, Yong Hyeon; Kim, Mun Ki; Hong, Gyeong Eun; Lee, Ho Jeong; Nagappan, Arulkumar; Yumnam, Silvia; Kim, Eun Hee; Heo, Jeong Doo; Lee, Sang Joon; Won, Chung Kil; Kim, Gon Sup

    2015-01-01

    Grifola frondosa (GF), distributed widely in far east Asia including Korea, is popularly used as traditional medicines and health supplementary foods, especially for enhancing the immune functions of the body. To extend the application of GF polysaccharides (GFP) for atopic dermatitis (AD), we investigated the effects of GFP on the 2,4-dinitrochlorobenzene-induced AD-like skin lesion in NC/Nga mice. GFP treatment significantly reduced the dorsa skin dermatitis score and combination treatment with GFP, and dexamethasone has a synergistic effect in AD-like skin lesion by reduced Serum IgE, mast cells infiltration, and cytokines expression. These results indicate that GFP suppressed the AD-like skin lesions by controlling the Th-1/Th-2-type cytokines in NC/Nga mice. These findings strongly suggest that GFP can be useful for AD patients as a novel therapeutic agent and might be used for corticosteroids replacement or supplement agent. PMID:25248662

  5. Control of Grifola frondosa Morphology by Agitation and Aeration for Improving Mycelia and Exo-Polymer Production.

    PubMed

    Cui, Feng-Jie; Chen, Xiao-Xiao; Liu, Wei-Min; Sun, Wen-Jing; Huo, Shuhao; Yang, Yan

    2016-06-01

    The present study describes the improved mycelia and exo-polymer production under control of Grifola frondosa morphology by changing the aeration rate and agitation intensity in a 25-L stirred fermentor. The aeration rate of 1.0 vvm yielded a highest mycelia biomass of 24.754 g/L with the lowest pellet percentage of 20.5 %. The maximum exo-polymer (2.324 g/L) was achieved at 0.75 vvm with mycelia polysaccharide production (0.321 g/g), whereas clumps and filaments dominated the ratios of 45.6 and 33.9 %, respectively. The change of aeration rate and agitation intensity had slight influence on the monosaccharide compositions in exo-polymers and significantly affected glucose and mannose contents in the mycelia polysaccharides. These findings will provide a clue for exploring the relationship between fermentation parameters, morphologies, and polysaccharide synthesis pathway of G. frondosa. PMID:26861733

  6. Structural analysis of anti-tumor heteropolysaccharide GFPS1b from the cultured mycelia of Grifola frondosa GF9801.

    PubMed

    Cui, F J; Tao, W Y; Xu, Z H; Guo, W J; Xu, H Y; Ao, Z H; Jin, J; Wei, Y Q

    2007-01-01

    A 21-kDa heteropolysaccharide, coded as GFPS1b, was obtained from the cultured mycelia of Grifola frondosa GF9801 by hot-water extraction, ethanol precipitation, and fractioned by DEAE Sepharose Fast-flow, followed by the purification with Sephadex G-100 column chromatography using an AKTA purifier. It exhibited more potent anti-proliferative activity on MCF-7 cells than other polysaccharide fractions. GFPS1b was an acidic polysaccharide with approximately 16.60% protein and 4.3% uronic acid. Gas chromatography of absolute acid hydrolysate of GFPS1b suggested that it was composed of D-glucose, D-galactose, and L-arabinose with a molar ratio of 4:2:1. Periodate oxidation, Smith degradation, partial acid hydrolyzation, methylation analysis, FT-IR, and (1)H, (13)C NMR spectroscopy analysis revealed that GFPS1b had a backbone consisting of alpha-(1-->4)-linked D-galacopyranosyl and alpha-(1-->3)-linked D-glucopyranosyl residues substituted at O-6 with glycosyl residues composed of alpha-L-arabinose-(1-->4)-alpha-D-glucose (1--> linked residues. PMID:16459075

  7. Purification and Partial Characterization of a Novel Anti-tumor Glycoprotein from Cultured Mycelia of Grifola frondosa.

    PubMed

    Cui, Fengjie; Zan, Xinyi; Li, Yunhong; Yang, Yan; Sun, Wenjing; Zhou, Qiang; Yu, Silian; Dong, Ying

    2013-10-25

    A novel glycoprotein GFG-3a with the molecular weight of 88.01 kDa and potent anti-tumor activity was isolated from the cultured mycelia of Grifola frondosa GF9801. GFG-3a was heat-sensitive with the decreasing anti-proliferative activity after treated from 56°C to 100°C for 10-120min. GFG-3a was a glycoprotein with O-glycosylation and contained 6.20% carbohydrate composed of D-arabinose, D-fructose, D-mannose, and D-glucose with a molar ratio of 1.33:4.51:2.46:1.00. FT-IR and NMR spectra proved that GFG-3a contained protein and carbohydrate portions with 3-O-methyl-galactose residues, (1→4)-linked β- galactose residues, and β-linked glucose residues. Circular dichroism (CD) revealed that GFG-3a was a predominantly β-sheet glycoprotein with a relatively small α-helical content. Protein sequencing and 3D model of GFG-3a were finally obtained by using MALDI-TOF-MS, NCBI blast search and online SWISS-MODLE Workspace service. Our findings will be a reference for the further structure-activity relationship analysis of the mushroom glycoproteins. PMID:24512992

  8. Anti-tumor and immunomodulatory activity of selenium (Se)-polysaccharide from Se-enriched Grifola frondosa.

    PubMed

    Mao, Guang-Hua; Ren, Yi; Li, Qian; Wu, Hui-Yu; Jin, Dun; Zhao, Ting; Xu, Cai-Quan; Zhang, Deng-Hong; Jia, Qing-Dong; Bai, Yan-Peng; Yang, Liu-Qing; Wu, Xiang-Yang

    2016-01-01

    A polysaccharide termed Se-GP11 was extracted and purified from Se-enriched Grifola frondosa in our previous study. This study investigated the characterization, anti-tumor and immunomodulatory activity of Se-GP11. The results showed that Se-GP11 was composed of mannose, glucose and galactose with a molar ratio of 1:4.91:2.41. The weight-average molecular weight (Mw) and weight-average mean square radius (Rw) of Se-GP11 in 0.1M sodium chloride solution were 3.3×10(4)Da and 32.8 nm. Se-GP11 existed as a globular conformation with random coil structure. Se-GP11 had no anti-tumor activity against HepG-2 cells in vitro, and it significantly inhibited the growth of Heps tumor in vivo. Se-GP11 increased the relatively thymus and spleen weights as well as serum necrosis factor-alpha (TNF-α) and interleukin-2 (IL-2) levels. In addition, Se-GP11 promoted the phagocytosis and NO production of RAW264.7 as compared with that of the normal control group. The results revealed that the Se-GP11 may exhibit the anti-tumor through improving immunologic function of the tumor bearing mice. PMID:26522247

  9. Inhibitory potential of Grifola frondosa bioactive fractions on α-amylase and α-glucosidase for management of hyperglycemia.

    PubMed

    Su, Chun-Han; Lu, Tzy-Ming; Lai, Min-Nan; Ng, Lean-Teik

    2013-01-01

    This study examined the inhibitory effects of Grifola frondosa (GF), a medicinal mushroom popularly consumed in traditional medicine and health food, on digestive enzymes related to type 2 diabetes; chemical profiles and inhibitory kinetics of its bioactive fractions were also analyzed. Results showed that all GF extracts showed weak anti-α-amylase activity; however, strong anti-α-glucosidase activity was noted on GF n-hexane extract (GF-H). Further fractionation confirmed that compared with acarbose (a commercial α-glucosidase inhibitor), the nonpolar fraction of GF possessed a stronger anti-α-glucosidase activity but a weaker anti-α-amylase activity. These activities were not derived from ergosterol and ergosterol peroxide, two major compounds of this fraction. The inhibitory kinetics of GF-H on α-glucosidase was competitive inhibition. GF-H was as good as acarbose in inhibiting the starch digestion in vitro. Oleic acid and linoleic acid could be the major active constituents that have contributed to the potency of GF in inhibiting α-glucosidase activity. PMID:24033596

  10. Grifola frondosa Glycoprotein GFG-3a Arrests S phase, Alters Proteome, and Induces Apoptosis in Human Gastric Cancer Cells.

    PubMed

    Cui, Fengjie; Zan, Xinyi; Li, Yunhong; Sun, Wenjing; Yang, Yan; Ping, Lifeng

    2016-01-01

    GFG-3a is a novel glycoprotein previously purified from the fermented mycelia of Grifola frondosa with novel sugar compositions and protein sequencing. The present study aims to investigate its effects on the cell cycle, differential proteins expression, and apoptosis of human gastric cancer SGC-7901 cells. Our findings revealed that GFG-3a induced the cell apoptosis and arrested cell cycle at S phase. GFG-3a treatment resulted in the differential expression of 21 proteins in SGC-7901 cells by upregulating 10 proteins including RBBP4 associated with cell cycle arrest and downregulating 11 proteins including RUVBL1, NPM, HSP90AB1, and GRP78 involved in apoptosis and stress response. qRT-PCR and Western blot analysis also suggested that GFG-3a could increase the expressions of Caspase-8/-3, p53, Bax, and Bad while decrease the expressions of Bcl2, Bcl-xl, PI3K, and Akt1. These results indicated that the stress response, p53-dependent mitochondrial-mediated, Caspase-8/-3-dependent, and PI3k/Akt pathways were involved in the GFG-3a-induced apoptosis process in SGC-7901 cells. These findings might provide a basis to prevent or treat human gastric cancer with GFG-3a and understand the tumor-inhibitory molecular mechanisms of mushroom glycoproteins. PMID:27040446

  11. Characterization of a novel maitake (Grifola frondosa) protein that activates natural killer and dendritic cells and enhances antitumor immunity in mice.

    PubMed

    Tsao, Yao-Wei; Kuan, Yen-Chou; Wang, Jia-Lin; Sheu, Fuu

    2013-10-16

    Grifola frondosa, also known as maitake, is a culinary mushroom with immune-enhancing and antitumor effects. Numerous studies have investigated the activity of maitake polysaccharide extracts, but studies of maitake proteins are scarce. In this study, we purified and characterized a new G. frondosa protein, GFP, from maitake fruiting bodies. GFP is a nonglucan heterodimeric 83 kDa protein that consists of two 41 kDa subunits. GFP induced interferon-γ secretion by murine splenocytes and natural killer cells and activated the maturation of bone marrow-derived dendritic cells (BMDCs) via a TLR4-dependent mechanism. GFP-treated BMDCs promoted a Th1 response and exhibited significant antitumor activity when transferred into tumor-bearing mice. In conclusion, we are the first to reveal the critical role of GFP in modulating the immune response and to link the immune-enhancing effects of maitake to its antitumor activities. PMID:24020458

  12. Pharmacological and pharmacokinetic studies with agaricoglycerides, extracted from Grifola frondosa, in animal models of pain and inflammation.

    PubMed

    Han, Chuncho; Cui, Bo

    2012-08-01

    The objective of the present study was to demonstrate the anti-inflammatory and antinociceptive properties of agaricoglycerides of the fermented mushroom of Grifola frondosa (AGF). The effects of AGF on interleukin-1β (IL-1β) levels, tumor necrosis factor-α (TNF-α) levels, nuclear factor kappa B (NF-κB) levels, intercellular adhesion molecule-1 (ICAM-1) levels, cyclooxygenase-2 (COX-2) levels, and inducible nitric oxide synthase (iNOS) levels were determined by ELISA. The antinociceptive effects of AGF were also analyzed in acetic acid-induced pain model and formalin-induced inflammatory pain model, respectively. At the same time, the pharmacokinetic assay of AGF was also made. AGF at the dose level of 500 mg/kg significantly inhibited LPS-induced upregulation of NF-κB activation and the production of IL-1β, TNF-α, iNOS, ICAM-1, and COX-2. Moreover, AGF at the dose level of 500 mg/kg suppressed the acetic acid-induced abdominal constrictions (p < 0.05) and the formalin-induced spontaneous nociceptive behaviors (p < 0.05) in rats. The total plasma concentrations of drug after oral administration of AGF at the dose level of 500 mg/kg led to an improvement in oral bioavailability. It accounts for the anti-inflammatory and antinociceptive activity of AGF. The present study demonstrated that AGF at the dose level of 500 mg/kg has important anti-inflammatory and antinociceptive effects in preclinical models of inflammation and in some models of pain and thus may be used as an alternative medicine for inflammatory pain. PMID:22327864

  13. Hypoglycemic effects of Grifola frondosa (Maitake) polysaccharides F2 and F3 through improvement of insulin resistance in diabetic rats.

    PubMed

    Xiao, Chun; Wu, Qingping; Xie, Yizhen; Zhang, Jumei; Tan, Jianbin

    2015-11-01

    Our laboratory has previously demonstrated that Grifola frondosa polysaccharides (GFPs) showed hypoglycemic effects. This study aimed to investigate which polysaccharide-enriched fractions of GFPs were the main active constituents, and to disclose their hypoglycemic mechanism. F2 and F3 were obtained from GFPs and their hypoglycemic effects were investigated. Fasting serum glucose (FSG) levels, fasting serum insulin (FSI) levels and a homeostasis model assessment of insulin resistance (HOMA-IR) were measured, and the hepatic mRNA levels of insulin receptor (IR), insulin receptor substrate-1 (IRS-1), protein tyrosine phosphatase-1B (PTP1B), phosphatidylinositol 3-kinase (PI3K) and Akt/protein kinase B (PKB) were determined by a quantitative polymerase chain reaction (qPCR). The activity of IR and IRS-1 were determined by an enzyme-linked immunosorbent assay (ELISA), and their phospho-protein levels were analyzed with western blotting. F2 and F3 significantly decreased the levels of FSG, FSI and HOMA-IR compared with a diabetic control group (P < 0.05). F2 and F3 increased the activity and mRNA levels of IR, and the latter also increased the mRNA levels of IRS-1. As for the protein levels of phospho-IR and IRS-1, both F2 and F3 increased the protein levels of IR (Try 1361), but decreased IRS-1 (Ser307). In the PI3K/Akt pathway, F3 increased the mRNA levels of PI3K and Akt, however, F2 inhibited PTP1B expression. F2 and F3 are presumed to cause an improvement in insulin resistance, triggered by the reactivation of IR and IRS-1. PMID:26311233

  14. Submerged-Culture Mycelia and Broth of the Maitake Medicinal Mushroom Grifola frondosa (Higher Basidiomycetes) Alleviate Type 2 Diabetes-Induced Alterations in Immunocytic Function.

    PubMed

    Chen, Ya-Hui; Lee, Chien-Hsing; Hsu, Tai-Hao; Lo, Hui-Chen

    2015-01-01

    Type 2 Diabetes mellitus (T2DM), a disease with impaired glucose, protein and lipid metabolism, low-grade chronic inflammation, and immune dysfunction, is a global public health crisis. We previously demonstrated that Grifola frondosa has bioactivities in improving glycemic responses in diabetic rats. Herein, we investigated the immunomodulatory effects of the submerged-culture mycelia and broth of G. frondosa on the peripheral blood cells (PBL) and splenocytes. Male Wistar rats were administered with saline (normal rats) or streptozotocin plus nicotinamide (T2DM rats) and were intragastrically administered with placebo, fermented mycelia, broth, or mycelia plus broth (1 g kg-1 day-1) for two weeks. In normal rats, ingestion of mycelia significantly decreased monocytes and ingestion of mycelia and broth significantly decreased the productions of interferon (IFN)-γ and interleukin (IL)-4 from the PBL and splenocytes. In T2DM rats, ingestion of mycelia, broth, and mycelia plus broth significantly alleviated the increases in 2 h postprandial blood glucose and the productions of IFN-γ from the T-leukocytes, IL-4, and IL-6 from the monocytes and IL-4 from the T-splenocytes, as well as significantly improved the productions of tumor-necrosis factor-α from the macrophages. In conclusion, submerged-culture mycelia and broth of G. frondosa may decrease cell-medicated immunity in normal rats and improve hyperglycemia and diabetes-induced alterations in cell-medicated and innate immunities in T2DM rats. PMID:26349512

  15. Profiling of hepatic gene expression of mice fed with edible japanese mushrooms by DNA microarray analysis: comparison among Pleurotus ostreatus, Grifola frondosa, and Hypsizigus marmoreus.

    PubMed

    Sato, Mayumi; Tokuji, Yoshihiko; Yoneyama, Shozo; Fujii-Akiyama, Kyoko; Kinoshita, Mikio; Ohnishi, Masao

    2011-10-12

    To compare and estimate the effects of dietary intake of three kinds of mushrooms (Pleurotus ostreatus, Grifola frondosa, and Hypsizigus marmoreus), mice were fed a diet containing 10-14% of each mushroom for 4 weeks. Triacylglycerol in the liver and plasma decreased and plasma cholesterol increased in the P. ostreatus-fed group compared with those in the control group. Cholesterol in the liver was lower in the G. frondosa-fed group than in the control group, but no changes were found in the H. marmoreus-fed group. DNA microarray analysis of the liver revealed differences of gene expression patterns among mushrooms. Ctp1a and Fabp families were upregulated in the P. ostreatus-fed group, which were considered to promote lipid transport and β-oxidation. In the G. frondosa-fed group, not only the gene involved in signal transduction of innate immunity via TLR3 and interferon but also virus resistance genes, such as Mx1, Rsad2, and Oas1, were upregulated. PMID:21910414

  16. Immunomodulating activities of cultivated maitake medicinal mushroom Grifola frondosa (Dicks.: Fr.) S.F. Gray (higher Basidiomycetes) on peripheral blood mononuclear cells.

    PubMed

    Svagelj, Mirjan; Berovic, Marin; Gregori, Andrej; Wraber, Branka; Simcic, Sasa; Boh, Bojana

    2012-01-01

    Grifola frondosa is a culinary-medicinal mushroom that contains several physiologically active compounds, of which polysaccharides, specifically β-glucans, are known to possess immunomodulating properties. Its extracts are studied for application as adjuncts for chemotherapy, and experiments in animal models support the use of this mushroom for cancer treatment. The effect of extracts obtained from mushrooms cultivated on different substrates and their capacity of inducing the secretion of cytokines from human peripheral blood mononuclear cells were studied. The activity of extracts at concentrations 12.5, 100, and 200 μg/mL on induction of TNF-α, IFN-γ, and IL-12 was screened. Two extracts from substrates fortified with olive oil press cakes showed appreciable activity and induced the secretion of TNF-α, IL-12, and INF-γ. The extracts differed from the others in the amount of sugar, protein, and β-glucans, which can explain their higher activity. Present results show that different substrates and different source materials can reasonably modify the bioactivity of cultivated G. frondosa. PMID:23510175

  17. Structural characterization and immunomodulatory activity of Grifola frondosa polysaccharide via toll-like receptor 4-mitogen-activated protein kinases-nuclear factor κB pathways.

    PubMed

    Ma, Xiaolei; Meng, Meng; Han, Lirong; Cheng, Dai; Cao, Xiaohong; Wang, Chunling

    2016-06-15

    We isolated a neutral polysaccharide from the fruiting body of a mushroom Grifola frondosa (GFP-A). The aim of this study was to characterize a neutral α-d-polysaccharide derived from G. frondosa and evaluate its immunomodulatory effect on toll-like receptor 4, mitogen-activated protein kinases and nuclear factor κB pathways of protein expression in macrophages. The structural features of GFP-A were characterized by physicochemical and instrumental analyses. Its molecular weight was found to be 8.48 × 10(2) kDa. The main chain of GFP-A consisted of (1 → 4)-linked and (1 → 6)-linked α-d-glucopyranosyl, and (1 → 3,6)-linked α-d-mannopyranosyl residues, which branched at C-3. The branches consisted of (1 → 6)-linked α-d-galactopyranosyl and t-l-rhamnopyranosyl residues. An in vitro immunomodulatory assay for pro-inflammatory cytokines (interleukin-1β, interleukin-2, tumor necrosis factor alpha, etc.) using the macrophage cell line, RAW 264.7, revealed that GFP-A exhibited significant immunomodulatory activity by stimulating the toll-like receptor 4, mitogen-activated protein kinases to nuclear factor κB/pathway. PMID:27220562

  18. Solid-state cultivation of Grifola frondosa (Dicks: Fr) S.F. Gray biomass and immunostimulatory effects of fungal intra- and extracellular beta-polysaccharides.

    PubMed

    Svagelj, Mirjan; Berovic, Marin; Boh, Bojana; Menard, Anja; Simcic, Sasa; Wraber, Branka

    2008-01-01

    Grifola frondosa strain GF3, was cultivated on solid-state substrate consisting of milled whole corn plant (Zea mays) and olive press cake supplemented with mineral additives and olive oil. Maintenance of the moisture content in the solid substrate is of crucial importance. Moistures higher than 70% promote growth of G. frondosa mycelium and polysaccharide production. Four fractions of pure extracellular beta-D-glucans with total mass 127.2mg and four fractions of intracellular polysaccharides with total mass 47.2mg were isolated. Polysaccharides were further separated by ion-exchange, gel and affinity chromatography. Isolated polysaccharide fractions from fungal mycelium proved to induce moderate amounts of TNF-alpha in PBMC cells in vitro. The extent of TNF-alpha induction was up to 322pgmL(-1) at a polysaccharide concentration of 200microgmL(-1) for the intracellular fraction. The TNF-alpha inducing activity is comparable to romurtide, which has been used as a supporting therapy in cancer patients treated with radiotherapy and/or chemotherapy. PMID:18786661

  19. MT-α-glucan from the fruit body of the maitake medicinal mushroom Grifola frondosa (higher Basidiomyetes) shows protective effects for hypoglycemic pancreatic β-cells.

    PubMed

    Lei, Hong; Zhang, Minmin; Wang, Qin; Guo, Shuzhen; Han, Juncheng; Sun, Hanju; Wu, Wutong

    2013-01-01

    The hypoglycemic effect of an α-glucan (designated here as MT-α-glucan) from the fruit body of the Maitake medicinal mushroom, Grifola frondosa, on a murine type 2 diabetes mellitus (T2DM) model was evaluated. Body weight and levels of fasting plasma glucose, glycosylated hemoglobin, triglycerides, cholesterol, free fatty acid, nitric oxide (NO), NO synthase, inducible NO synthase, and hepatic malondialdehyde content decreased significantly when MT-α-glucan was administered to T2DM mice. The content of serum insulin, hepatic glycogen, and reduced glutathione and the activity of superoxide dismutase and glutathione peroxidase increased significantly when MT-α-glucan was administered to T2DM mice. Histopathological changes of the pancreas were ameliorated in the treatment group. These data suggest that MT-α-glucan has a hypoglycemic effect on T2DM mice, which might be related to its protective effect of pancreatic β-cells exerted by decreasing levels of factors that destroy β-cells, such as oxidative stress and NO synthesis. PMID:23796219

  20. Investigation of the Optimum Farming Temperature for Grifola frondosa and Growth Promotion using the Bio-Electric Potential as an Index

    NASA Astrophysics Data System (ADS)

    Yanagibashi, Hideyuki; Hirama, Junji; Matsuda, Masato; Miyamoto, Toshio

    The purpose of this study was to investigate the optimum farming conditions for mushrooms from the view point of engineering field. As the bio-electric potential of mushrooms is considered to be closely related to the activation of mushroom cells, this relationship has been used to analyze the dependence of the morphogenetic characteristics of Grifola frondosa on farming temperatures (from 16 to 22 degree C). The experimental results indicated that a maximum response was exhibited, with correspondingly favorable morphogenesis obtained at 18 degree C. Based on the experimental results, including those in a previous study, it was assumed that the larger the bio-electric potential becomes, the higher the growth yield reaches. In order to support this assumption, growth promotion was conducted by intentionally activating the bio-electric potential within the mushrooms by stimulating them with short bursts of illumination. The resulting observation of growth promotion permitted the conclusion that the bio-electric potential can, indeed, be regarded as an index of growth.

  1. Oral administration of soluble β-glucans extracted from Grifola frondosa induces systemic antitumor immune response and decreases immunosuppression in tumor-bearing mice.

    PubMed

    Masuda, Yuki; Inoue, Hiroko; Ohta, Hiroya; Miyake, Ayumi; Konishi, Morichika; Nanba, Hiroaki

    2013-07-01

    Maitake D (MD)-Fraction is a highly purified soluble β-glucan derived from Grifola frondosa (an oriental edible mushroom). Intraperitoneal (i.p.) injection of MD-Fraction has been reported to inhibit tumor growth via enhancement of the host immune system. In this study, we demonstrated that oral administration of MD-Fraction as well as i.p. injection significantly inhibited tumor growth in murine tumor models. After oral administration, MD-Fraction was not transferred to the blood in its free form but was captured by antigen-presenting cells such as macrophages and dendritic cells (DCs) present in the Peyer's patch. The captured MD-Fraction was then transported to the spleen, thereby inducing the systemic immune response. Our study showed that MD-Fraction directly induced DC maturation via a C-type lectin receptor dectin-1 pathway. The therapeutic response of orally administered MD-Fraction was associated with (i) induced systemic tumor-antigen specific T cell response via dectin-1-dependent activation of DCs, (ii) increased infiltration of the activated T cells into the tumor and (iii) decreased number of tumor-caused immunosuppressive cells such as regulatory T cells and myeloid-derived suppressor cells. Our preclinical study suggests that MD-Fraction is a useful oral therapeutic agent in the management of patients with cancer. PMID:23280601

  2. A heteropolysaccharide, L-fuco-D-manno-1,6-α-D-galactan extracted from Grifola frondosa and antiangiogenic activity of its sulfated derivative.

    PubMed

    Wang, Ying; Shen, Xiaokun; Liao, Wenfeng; Fang, Jianping; Chen, Xia; Dong, Qun; Ding, Kan

    2014-01-30

    The tumor growth and metastasis are angiogenesis dependent, thus blockade of angiogenesis is a promising approach for treatment of cancer. Herein we reported the structural and biological features of a novel water-soluble polysaccharide named GFPW from the fruit body of Grifola frondosa. Chemical and spectral analysis revealed that GFPW with an average molecular weight of 15.7 kDa, possessed a backbone consisting of α-1,6-linked galactopyranosyl residues, with branches attached to O-2 of α-1,3-linked fucose residues and α-terminal mannose. By the chlorosulfonic acid-pyridine method, we prepared a sulfated derivative of GFPW, Sul-GFPW, with a substitution degree of 0.33. According to the (13)C NMR spectrum, the substitution position was deduced at C-2 and C-3. The angiogenesis assays in vitro showed that Sul-GFPW significantly inhibited endothelial cell proliferation in a dose- and time-dependent manner, and reduced endothelial cell migration and tube formation as well. PMID:24299820

  3. Cold-water extracts of Grifola frondosa and its purified active fraction inhibit hepatocellular carcinoma in vitro and in vivo.

    PubMed

    Lin, Chia-Hung; Chang, Ching-Yao; Lee, Kuan-Rong; Lin, Hui-Ju; Lin, Wu-Chou; Chen, Ter-Hsin; Wan, Lei

    2016-07-01

    Mushrooms are used in traditional Chinese medicine to treat a variety of diseases. Grifola frondosa (GF) is an edible mushroom indigenous to many Asian countries with a large fruiting body characterized by overlapping caps. In particular, GF is known for its anti-tumor activity, which has been targeted by scientific and clinical research. This study aimed to investigate the effects of the cold-water extract of GF (GFW) and its active fraction (GFW-GF) on autophagy and apoptosis, and the underlying mechanisms in vitro and in vivo Our results revealed that GFW and GFW-GF inhibited phosphatidylinositol 3-kinase (PI3K) and stimulated c-Jun N-terminal kinase (JNK) pathways, thereby inducing autophagy. We also demonstrated that GFW and GFW-GF inhibited proliferation, induced cell cycle arrest, and apoptosis in Hep3B hepatoma cells. GFW and GFW-GF markedly arrested cells in S phase and promoted cleavage of caspase-3 and -9. In addition, GFW and GFW-GF decreased the expression levels of the anti-apoptotic proteins protein kinase B and extracellular signal-regulated kinase. We also found that GFW significantly inhibited tumor growth in nude mice implanted with Hep3B cells. Our work demonstrates that GF and its active fraction inhibit hepatoma growth by inducing autophagy and apoptosis. PMID:27013543

  4. Soluble β-glucan from Grifola frondosa induces proliferation and Dectin-1/Syk signaling in resident macrophages via the GM-CSF autocrine pathway.

    PubMed

    Masuda, Yuki; Togo, Takuya; Mizuno, Shigeto; Konishi, Morichika; Nanba, Hiroaki

    2012-04-01

    MD-Fraction, a highly purified, soluble β-(1,3) (1,6)-glucan obtained from Grifola frondosa (an oriental edible mushroom), has been reported to inhibit tumor growth by modulating host immunity. β-Glucan, a major component of the fungal cell wall, is generally recognized by PRRs expressed on macrophages and DCs, such as Dectin-1, and the ability of β-glucans to modulate host immunity is influenced by their structure and purity. Most cellular studies have used particulate β-glucans, such as yeast zymosan (crude β-glucan) and curdlan (purified β-glucan). However, little is known about the cellular mechanism of soluble β-glucans, including MD-Fraction, despite significant therapeutic implications. In this study, we investigated the cellular mechanism of MD-Fraction in murine resident macrophages and compared it with two well-known β-glucan particles. MD-Fraction induced GM-CSF production rapidly through Dectin-1-independent ERK and p38 MAPK activation. Subsequently, MD-Fraction-induced GM-CSF enhanced proliferation and Dectin-1 expression, which permitted Dectin-1-mediated TNF-α induction through the Syk pathway. Curdlan induced not only the proliferation and activation of Dectin-1/Syk signaling in a manner similar to MD-Fraction but also the uncontrolled, proinflammatory cytokine response. Contrastingly, zymosan reduced proliferation and Dectin-1 expression significantly, indicating that the mechanism of macrophage activation by MD-Fraction differs from that of zymosan. This is the first study to demonstrate that purified β-glucans, such as MD-Fraction and curdlan, induce GM-CSF production directly, resulting in Dectin-1/Syk activation in resident macrophages. In conclusion, we demonstrated that MD-Fraction induces cell proliferation and cytokine production without excessive inflammation in resident macrophages, supporting its immunotherapeutic potential. PMID:22028332

  5. Structure of a β-glucan from Grifola frondosa and its antitumor effect by activating Dectin-1/Syk/NF-κB signaling.

    PubMed

    Fang, Jianping; Wang, Ying; Lv, Xiaofen; Shen, Xiaokun; Ni, Xinyan; Ding, Kan

    2012-08-01

    A soluble homogeneous β-glucan, GFPBW1, with a molecular mass of 300 kDa was purified from the fraction of the fruit bodies of Grifola frondosa extracted with 5% NaOH. Using various methods, such as infrared spectroscopy, NMR, methylation and monosaccharide composition analysis, its structure was determined to be a β-D-(1-3)-linked glucan backbone with a single β-D-(1-6)-linked glucopyranosyl residue branched at C-6 on every third residue. It induced TNF-α and IL-6 production and the activation of Syk and NF-κB signaling in resident peritoneal macrophages from ICR mice, which could be significantly inhibited by the blocking reagent laminarin. A competitive phagocytosis assay with FITC-zymosan indicated that GFPBW1 could bind to DC-associated C-type lectin 1 (Dectin-1). The TNF-α secretion and activation of Syk/NF-κB signaling triggered by GFPBW1 were enhanced in RAW264.7 cells overexpressing wild but not mutant (Δ38 and Y15S) Dectin-1. Furthermore, GFPBW1 potentiated the Concanavalin A-induced proliferative response of splenocytes and inhibited Sarcoma-180 growth allografted in ICR mice but not in immunodeficient BALB/c nu/nu mice. These results suggested that the antitumor activity of GFPBW1 was partially associated with the activation of macrophages via the Dectin-1/Syk/NF-κB signaling pathway. This molecule could be a promising biological response modifier with clear application for antitumor therapies. PMID:22744837

  6. Soluble β-glucan from Grifola frondosa induces tumor regression in synergy with TLR9 agonist via dendritic cell-mediated immunity.

    PubMed

    Masuda, Yuki; Nawa, Daiki; Nakayama, Yoshiaki; Konishi, Morichika; Nanba, Hiroaki

    2015-12-01

    The maturation of dendritic cells into more-immunostimulatory dendritic cells by stimulation with different combinations of immunologic agents is expected to provide efficient, adoptive immunotherapy against cancer. Soluble β-glucan maitake D-fraction, extracted from the maitake mushroom Grifola frondosa, acts as a potent immunotherapeutic agent, eliciting innate and adoptive immune responses, thereby contributing to its antitumor activity. Here, we evaluated the efficacy of maitake D-fraction, in combination with a Toll-like receptor agonist, to treat tumors in a murine model. Our results showed that maitake D-fraction, in combination with the Toll-like receptor 9 agonist, cytosine-phosphate-guanine oligodeoxynucleotide, synergistically increased the expression of dendritic cell maturation markers and interleukin-12 production in dendritic cells, but it did not increase interleukin-10 production, generating strong effector dendritic cells with an augmented capacity for efficiently priming an antigen-specific, T helper 1-type T cell response. Maitake D-fraction enhances cytosine-phosphate-guanine oligodeoxynucleotide-induced dendritic cell maturation and cytokine responses in a dectin-1-dependent pathway. We further showed that a combination therapy using cytosine-phosphate-guanine oligodeoxynucleotide and maitake D-fraction was highly effective, either as adjuvants for dendritic cell vaccination or by direct administration against murine tumor. Therapeutic responses to direct administration were associated with increased CD11c(+) dendritic cells in the tumor site and the induction of interferon-γ-producing CD4(+) and CD8(+) T cells. Our results indicate that maitake D-fraction and cytosine-phosphate-guanine oligodeoxynucleotide synergistically activated dendritic cells, resulting in tumor regression via an antitumor T helper cell 1-type response. Our findings provide the basis for a potent antitumor therapy using a novel combination of immunologic agents for

  7. A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: immunological effects

    PubMed Central

    Lin, Hong; Seidman, Andrew; Fornier, Monica; D’Andrea, Gabriella; Wesa, Kathleen; Yeung, Simon; Cunningham-Rundles, Susanna; Vickers, Andrew J.; Cassileth, Barrie

    2013-01-01

    Background Cancer patients commonly use dietary supplements to “boost immune function”. A polysaccharide extract from Grifola frondosa (Maitake extract) showed immunomodulatory effects in preclinical studies and therefore the potential for clinical use. Whether oral administration in human produces measurable immunologic effects, however, is unknown. Methods In a phase I/II dose escalation trial, 34 postmenopausal breast cancer patients, free of disease after initial treatment, were enrolled sequentially in five cohorts. Maitake liquid extract was taken orally at 0.1, 0.5, 1.5, 3, or 5 mg/kg twice daily for 3 weeks. Peripheral blood was collected at days −7, 0 (prior to the first dosing), 7, 14, and 21 for ex vivo analyses. The primary endpoints were safety and tolerability. Results No dose-limiting toxicity was encountered. Two patients withdrew prior to completion of the study due to grade I possibly related side effects: nausea and joint swelling in one patient; rash and pruritus in the second. There was a statistically significant association between Maitake and immunologic function (p < 0.0005). Increasing doses of Maitake increased some immunologic parameters and depressed others; the dose–response curves for many endpoints were non-monotonic with intermediate doses having either immune enhancing or immune suppressant effects compared with both high and low doses. Conclusions Oral administration of a polysaccharide extract from Maitake mushroom is associated with both immunologically stimulatory and inhibitory measurable effects in peripheral blood. Cancer patients should be made aware of the fact that botanical agents produce more complex effects than assumed, and may depress as well as enhance immune function. PMID:19253021

  8. Inducement of cytokine release by GFPBW2, a novel polysaccharide from fruit bodies of Grifola frondosa , through dectin-1 in macrophages.

    PubMed

    Wang, Ying; Fang, Jianping; Ni, Xinyan; Li, Jie; Liu, Qin; Dong, Qun; Duan, Jinyou; Ding, Kan

    2013-11-27

    Polysaccharides, especially β-glucans isolated from various species of mushrooms, are considered as biological response modifiers (BRMs) to be widely used in the treatment of cancer, especially due to their immunostimulatory activity. We herein characterized the structure of a novel water-soluble homogeneous polysaccharide (GFPBW2) from the fruit bodies of mushroom Grifola frondosa and investigated its immunomodulatory activity in vitro. GFPBW2 was purified from the alkali-extracted fractions by stepwise elution with a molecular weight of 26.2 kDa. On the basis of infrared and NMR spectroscopy, methylation and monosaccharide composition analysis, partial acid hydrolysis, and Smith degradation, its structure was elucidated to possess a backbone consisting of β-d-1,3- and β-d-1,4-linked glucopyranosyl residues, with branches attached to O-6 of β-d-1,3-linked glucopyranosyl residues. Functionally, it is an effective inducer of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) secretion in murine resident peritoneal macrophages. Using quartz crystal microbalance (QCM) analysis, we found that GFPBW2 could bind dendritic cell-associated C-type lectin-1 (Dectin-1) with an affinity constant (Kd) value of 1.08 × 10 (-7) M, while it could activate Syk and enhance TNF-α production in RAW264.7 cells overexpressing wild type but not mutant Dectin-1. Furthermore, Syk, NF-κB signaling, and cytokine release in resident peritoneal macrophages induced by GFPBW2 could be significantly inhibited by a specific Dectin-1 blocking reagent, Laminarin. These data suggested that GFPBW2 might be a potential ligand of Dectin-1, and the potential of GFPBW2 to activate macrophage through triggering cytokine secretion might be attributed, at least in part, to the involvement of Dectin-1. PMID:24229406

  9. Effects of Lentinus edodes, Grifola frondosa and Pleurotus ostreatus administration on cancer outbreak, and activities of macrophages and lymphocytes in mice treated with a carcinogen, N-butyl-N-butanolnitrosoamine.

    PubMed

    Kurashige, S; Akuzawa, Y; Endo, F

    1997-05-01

    ICR mice were treated with a carcinogen, N-butyl-N'-butanolnitrosoamine BBN), every day for 8 consecutive weeks and the effects of oral administration of edible mushrooms on the induction of urinary bladder carcinoma and on the activities of macrophages and lymphocytes were studied. Bladder carcinoma were found in all 10 mice (100%) treated with BBN alone, while we observed carcinoma only in 9 of 17 mice (52.9%), in 7 of 15 mice (46.7%) and 13 of 20 mice (65.0%) treated with Lentinus edodes, Grifola frondosa and Pleurotus ostreatus, respectively. Chemotactic activity of macrophages was suppressed in mice treated with BBN alone but maintained almost the normal level in mice treated with BBN plus Lentinus, Grifola or Pleurotus. Lymphocytes collected from mice treated with BBN plus each mushroom showed almost normal blastogenic response against concanavalin A, although those from mice treated with BBN alone completely retarded their response. Cytotoxic activity of lymphocytes against Yac-1 cells was also maintained at a normal level in mice treated with BBN plus each mushroom. Whereas in mice treated with BBN alone significant depression of NK cell activity occurred. Significantly higher cytotoxic activity against P-815 cells was observed in lymphocytes from mice treated with BBN plus each mushroom than that in lymphocytes from normal mice or mice treated with BBN alone. PMID:9130004

  10. In Vitro Studies of Secondary Metabolite-Related Responses in Some Species of Genus Grifola (Agaricomycetes) from Argentina.

    PubMed

    Postemsky, Pablo Daniel; Curvetto, Nestor Raul

    2016-01-01

    Grifola gargal Singer and Grifola sordulenta (Mont.) Singer mushrooms are related to Grifola frondosa (Dicks.) Gray, which is well known for its medicinal properties. In vitro studies were performed to find a useful guide for optimizing the environmental parameters through biotransformation of lignocellulosic materials and basidiome development, also considering secondary metabolism-related responses (SMRRs) associated with these processes and the variability among species and strains; this optimization is necessary to make the mushroom's industrial cultivation profitable. Morphological features of mycelial cultures revealed that intraspecific variability was of taxonomic relevance. A low ligninolytic capacity in studied Grifola species was observed when compared with 2 control species: G. frondosa and Ganoderma lucidum. Experiments with nutrient media containing different carbohydrate sources indicated that G. gargal mycelia grew better in xylulose and G. sordulenta, in xylulose or cellulose; in addition, the latter species presented cellobiose dehydrogenase activity. An additional study of SMRRs under different light conditions (aroma, pigmentation, and morphogenic manifestations) showed that white light was better than blue, green, or red-filtered light at inducing advanced SMRRs. The results of SMRR stimulation are proposed as useful guidance for optimizing the environmental parameters for bioprocesses aimed at metabolite production. PMID:27481302

  11. Enhancement of wheat grain antioxidant activity by solid state fermentation with Grifola spp.

    PubMed

    Postemsky, Pablo; Curvetto, Néstor

    2014-05-01

    Grifola frondosa, Grifola gargal, and Grifola sordulenta are edible and medicinal mushrooms with antioxidant properties. To obtain wheat flour (Wf ) with a higher antioxidant activity than the one exhibited by regular Wf, solid state fermentation (SSF) of wheat grains with mycelia of those Grifola spp. was used to obtain biotransformed wheat grain (BWG) flour. The methanolic extract of control Wf and BWG flour of G. gargal, G. sordulenta, and G. frondosa (GfWG, GgWG, and GsWG, respectively) were studied for their radical scavenging (RS) activity against 2,2-diphenyl-1-picrylhydracyl (DPPH) and their Fe(III) reducing power (RP). The values for RS-EC50 decreased in BWG flour, therefore presenting a higher antioxidant activity: GgWG (0.56 mg/mL), GfWG (0.81 mg/mL), and GsWG (5.80 mg/mL) in comparison to Wf (57.60 mg/mL). The antioxidant content for this RS activity in terms of ascorbic acid content (RS-EQAA) was highest in GfWG, followed by GgWG and GsWG (71.73, 14.46, and 3.02 mg/g, respectively) and lowest in Wf (0.25 mg/g). The RP-EC50 values in GgWG, GfWG, and GsWG were low (0.55, 0.64, and 4.20 mg/mL, respectively) with respect to Wf (55.00 mg/mL). Compared with Wf (0.56 mg/g), the RP capacity in terms of ascorbic acid content (RP-EQAA) was very high in GfWG (193.67 mg/g) followed by GgWG and GsWG (31.42 and 8.74 mg/g, respectively). The high content in gallic acid equivalents was consistent with RS-EQ(AA) and RP-EQ(AA) contents. TLC revealed that antioxidant activity in BWG could be related to the presence of phenolic compounds. Thus, a valuable food alternative can easily be obtained with wheat grains, that is, by markedly increasing their antioxidant value through SSF with Grifola spp. PMID:24552201

  12. Submerged Culture of Grifola gargal and G. sordulenta (Higher Basidiomycetes) from Argentina as a Source of Mycelia with Antioxidant Activity.

    PubMed

    Postemsky, Pablo Daniel; Curvetto, Néstor Raúl

    2015-01-01

    Submerged culture is an alternative mycelium source for Grifola gargal and G. sordulenta, two rare edible mushrooms related to Grifola frondosa. This work studies their mycelia as a source of antioxidants. The efficient concentrations of methanolic extracts in both radical scavenging (RS) and reducing power (RP) abilities in G. gargal and in G. sordulenta showed a high antioxidant activity. In the experimental design used, the antioxidant activity mainly depended on the culture conditions rather than on the media composition. Irrespective of the basal culture medium, mycelium methanolic extracts of G. sordulenta obtained from culture in Erlenmeyer flasks showed equivalents to ascorbic acid (EQ(AA)) RS-EQ(AA) and RP-EQ(AA) contents higher than the corresponding values obtained with jar cultures. Under stationary cultivation, G. sordulenta produced approximately 50% higher content in both RS-EQ(AA) and RP-EQ(AA) than the medicinal mushroom G. frondosa. Phenolics correlated with RS-EQ(AA) and RP-EQ(AA) in G. gargal and with RP-EQ(AA) in G. sordulenta; besides, thin-layer chromatography showed these compounds to be at least in part related to the RS capacity. It is concluded that G. gargal and G. sordulenta mycelia are excellent sources of antioxidant metabolites. PMID:25746407

  13. Immune-enhancing effects of Maitake (Grifola frondosa) and Shiitake (Lentinula edodes) extracts

    PubMed Central

    Vetvickova, Jana

    2014-01-01

    Background The role of glucan in stimulation of immune reactions has been studied for several decades. In this report, we focused on the effects of orally administered glucan Maitake and Shiitake on immune reactions. Materials and methods We measured phagocytosis, NK cell activity, and secretion of IL-6, IL-12, IFN-γ as well as C-reactive protein (CRP) after 14 days of oral application of tested glucans. For comparison, active hexose correlated compound (AHCC) was used in all reactions. Results We found significant stimulation of defense reaction. In all cases, the most active was the Maitake-Shiitake combination, with Maitake alone being the second strongest, followed by Shiitake on its own and AHCC. Conclusions Short-term oral application of natural immunomodulating glucans from Maitake and Shiitake mushrooms strongly stimulated both the cellular and humoral branch of immune reactions. These activities were significantly higher than those of AHCC. PMID:25332990

  14. Effect of Maitake (Grifola frondosa) D-Fraction on the activation of NK cells in cancer patients.

    PubMed

    Kodama, Noriko; Komuta, Kiyoshi; Nanba, Hiroaki

    2003-01-01

    Maitake D-Fraction, extracted from maitake mushroom, has been reported to exert its antitumor effect in tumor-bearing mice by enhancing the immune system through activation of macrophages, T cells, and natural killer (NK) cells. In a previous study, the combination of immunotherapy with the maitake D-Fraction and chemotherapy suggested that the D-Fraction may have the potential to decrease the size of lung, liver, and breast tumors in cancer patients. In the present study, we administered maitake D-Fraction to cancer patients without anticancer drugs, and at the same time NK cell activity was monitored to investigate whether the activity is closely related with disease progression. The numbers of CD4(+) and CD8(+) cells in the peripheral blood were measured in 10 patients, and NK cell activity was assessed using K-562 cells as target cells. Serum soluble interleukin-2 receptor (sIL-2R) levels in three patients and the expression of tumor markers in four patients were determined by enzyme-linked immunosorbent assay. The slight changes observed in the CD4(+) and CD8(+) cell numbers were independent of disease severity or stage as well as serum sIL-2R levels. In contrast, maitake D-Fraction hindered metastatic progress, lessened the expression of tumor markers, and increased NK cell activity in all patients examined. Thus maitake D-Fraction appears to repress cancer progression and primarily exerts its effect through stimulation of NK activity. In addition, we conclude that measurement of NK cell activity may be a useful clinical parameter in monitoring disease progression during and following immunotherapy with maitake D-Fraction. PMID:14977447

  15. Anti-Inflammatory Constituents from Bidens frondosa.

    PubMed

    Le, Jiamei; Lu, Wenquan; Xiong, Xiaojuan; Wu, Zhijun; Chen, Wansheng

    2015-01-01

    A new polyacetylene glucoside (3E,5E,11E)-tridecatriene-7,9-diyne-1,2,13-triol-2-O-β-D-glucopyranoside (1), a new phenylpropanoid glucoside 2'-butoxyethylconiferin (2), and a new flavonoid glycoside 8,3',4'-trihydroxyflavone-7-O-(6''-O-p-coumaroyl)-β-D-glucopyranoside (3), have been isolated from Bidens frondosa together with fifty-three known compounds 4-56. The structures of these compounds were established by spectroscopic methods. mainly ESIMS, 1D- and 2D-NMR spectroscopic data. and comparison with literature data. Compounds 1-34, 36, 39, 43, 47, 51, and 52 were tested for inhibition of nuclear factor kappa B (NF-κB) in 293-NF-κB-luciferase report cell line induced by lipopolysaccharide (LPS), and compounds 1, 2, 3, 9, 15, 21, 24 and 51 were tested for the production of TNF-α, IL-1β, IL-6, IL-10 in RAW 264.7 macrophages induced by LPS. In conclusion, the isolated compounds 1, 2, 3, 9, 15, 21, 24 and 51 exhibited significant activity in anti-inflammatory activity assays. PMID:26473814

  16. A chemically sulfated polysaccharide from Grifola frondos induces HepG2 cell apoptosis by notch1-NF-κB pathway.

    PubMed

    Wang, Chun-ling; Meng, Meng; Liu, Sheng-bin; Wang, Li-rui; Hou, Li-hua; Cao, Xiao-hong

    2013-06-01

    Sulfated polysaccharides have been known to inhibit proliferation in tumor cells. However, the molecular mechanisms involved in sulfated polysaccharides-induced apoptosis are still uncharacterized. In this study, the effect of a chemically sulfated polysaccharide obtained from Grifola frondosa (S-GFB) on HepG2 cell proliferation and apoptosis-related mechanism were investigated. It was found that S-GFB inhibited proliferation of HepG2 cells in a dose-dependent manner with IC50 at 48 h of 61 μg ml(-1). The results of scanning electron micrographs indicated that S-GFB induced typical apoptotic morphological feature in HepG2 cells. Flow cytometric analysis demonstrated that S-GFB caused apoptosis of HepG2 cells through cells arrested at S phase. Western-blotting results showed that S-GFB inhibited notch1 expression, IκB-α degradation and NF-κB/p65 translocation from cytoplasm into nucleus. Simultaneously, the apoptotic mechanism of HepG2 cells induced by S-GFB was associated with down regulation of FLIP, and activation of caspase-3 and caspase-8. Taken together, these findings suggest that the S-GFB induces apoptosis through a notch1/NF-κB/p65-mediated caspase pathway. PMID:23618270

  17. Amelioration of Atherosclerosis by the New Medicinal Mushroom Grifola gargal Singer.

    PubMed

    Harada, Etsuko; D'Alessandro-Gabazza, Corina N; Toda, Masaaki; Morizono, Toshihiro; Chelakkot-Govindalayathil, Ayshwarya-Lakshmi; Roeen, Ziaurahman; Urawa, Masahito; Yasuma, Taro; Yano, Yutaka; Sumiya, Toshimitsu; Gabazza, Esteban C

    2015-08-01

    The beneficial effects of edible mushrooms for improving chronic intractable diseases have been documented. However, the antiatherogenic activity of the new medicinal mushroom Grifola gargal is unknown. Therefore, we evaluated whether Grifola gargal can prevent or delay the progression of atherosclerosis. Atherosclerosis was induced in ApoE lipoprotein-deficient mice by subcutaneous infusion of angiotensin II. Grifola gargal extract (GGE) was prepared and intraperitoneally injected. The weight of heart and vessels, dilatation/atheroma formation of thoracic and abdominal aorta, the percentage of peripheral granulocytes, and the blood concentration of MCP-1/CCL2 were significantly reduced in mice treated with GGE compared to untreated mice. By contrast, the percentage of regulatory T cells and the plasma concentration of SDF-1/CXCL12 were significantly increased in mice treated with the mushroom extract compared to untreated mice. In vitro, GGE significantly increased the secretion of SDF-1/CXCL12, VEGF, and TGF-β1 from fibroblasts compared to control. This study demonstrated for the first time that Grifola gargal therapy can enhance regulatory T cells and ameliorate atherosclerosis in mice. PMID:25799023

  18. Amelioration of Atherosclerosis by the New Medicinal Mushroom Grifola gargal Singer

    PubMed Central

    Harada, Etsuko; D'Alessandro-Gabazza, Corina N.; Toda, Masaaki; Morizono, Toshihiro; Chelakkot-Govindalayathil, Ayshwarya-Lakshmi; Roeen, Ziaurahman; Urawa, Masahito; Yasuma, Taro; Yano, Yutaka; Sumiya, Toshimitsu

    2015-01-01

    ABSTRACT The beneficial effects of edible mushrooms for improving chronic intractable diseases have been documented. However, the antiatherogenic activity of the new medicinal mushroom Grifola gargal is unknown. Therefore, we evaluated whether Grifola gargal can prevent or delay the progression of atherosclerosis. Atherosclerosis was induced in ApoE lipoprotein-deficient mice by subcutaneous infusion of angiotensin II. Grifola gargal extract (GGE) was prepared and intraperitoneally injected. The weight of heart and vessels, dilatation/atheroma formation of thoracic and abdominal aorta, the percentage of peripheral granulocytes, and the blood concentration of MCP-1/CCL2 were significantly reduced in mice treated with GGE compared to untreated mice. By contrast, the percentage of regulatory T cells and the plasma concentration of SDF-1/CXCL12 were significantly increased in mice treated with the mushroom extract compared to untreated mice. In vitro, GGE significantly increased the secretion of SDF-1/CXCL12, VEGF, and TGF-β1 from fibroblasts compared to control. This study demonstrated for the first time that Grifola gargal therapy can enhance regulatory T cells and ameliorate atherosclerosis in mice. PMID:25799023

  19. Role of Butea Frondosa in Ameliorating Gastric Markers in Induced Gastric Lesions of Rats

    PubMed Central

    Banji, D.; Banji, Otilia J. F.; Singh, Meenu; Annamalai, A. R.

    2011-01-01

    The study evaluated the ability of the alcohol extract of Butea frondosa to protect the gastro-duodenal lining from injury inflicted by acetic acid and pyloric ligation in rats. The induced gastric lesions lead to the generation of alkaline phosphatase and pepsin, which serve as important markers of gastric damage. Alcohol extract of Butea frondosa was administered in doses of 10, 100, 300 and 500 mg/kg as a single schedule and for the time dependent studies in a dose of 100 mg/kg for 7, 14, 21 and 28 days, respectively. Our studies reveal a decline in the formation of alkaline phosphatase and pepsin with 300 and 500 mg/kg of the extract and following treatment for 21 and 28 days, respectively. Extract of Butea frondosa produces significant diminution in the formation of gastric markers implying possible gastro-protective action. PMID:22457555

  20. Antibacterial activity in Strongylocentrotus droebachiensis (Echinoidea), Cucumaria frondosa (Holothuroidea), and Asterias rubens (Asteroidea).

    PubMed

    Haug, Tor; Kjuul, Anita K; Styrvold, Olaf B; Sandsdalen, Erling; Olsen, Ørjan M; Stensvåg, Klara

    2002-10-01

    A search for antibacterial activity in different body parts of the green sea urchin Strongylocentrotus droebachiensis, the common starfish Asterias rubens, and the sea cucumber Cucumaria frondosa was conducted. Antibacterial activity was detected in extracts from several tissues in all species tested, but mainly in the coelomocyte and body wall extracts. Relatively high antibacterial activity could also be detected in gastrointestinal organs and eggs from A. rubens and in eggs from C. frondosa. Differences between active extracts regarding hydrophobicity and sensitivity to heat and proteinase K treatment indicated that several different compounds were responsible for the antibacterial activities detected. Lysozyme-like activity could be detected in several tissues from A. rubens. Haemolytic activity could be detected in all species tested, especially in the body wall extracts. Results from the current study suggest that marine echinoderms are a potential source for the discovery of novel antibiotics. PMID:12445793

  1. Biological and physicochemical properties of two polysaccharides from the mycelia of Grifola umbellate.

    PubMed

    Bi, Yunpeng; Miao, Ye; Han, Yan; Xu, Jian; Wang, Qing

    2013-06-20

    In the present study, we firstly reported the antioxidant, antitumor and immunomodulatory effects of two polysaccharides (GUMP-1-1 and GUMP-1-2) isolated from Grifola umbellata mycelia. Chemical analysis indicated that two polysaccharide fractions contained different content of neutral sugar, uronic acid and protein, as well as varying monosaccharide compositions and average molecular weight. We found that they could significantly inhibit the growth of H22 implanted tumor and enhance the spleen index and splenocyte proliferation of H22 tumor-bearing mice. In addition, GUMP-1-2 had the stronger free radicals scavenging and ferrous ion chelating abilities than GUMP-1-1 in vitro. These results indicated that antitumor activity of two purified polysaccharides might be achieved by improving immune response and the different chemical composition and average molecular weight could affect their antitumor, antioxidant and immunomodulatory activities. PMID:23648036

  2. Allelopathy of the invasive plant Bidens frondosa on the seed germination of Geum japonicum var. chinense.

    PubMed

    Wang, X F; Hassani, D; Cheng, Z W; Wang, C Y; Wu, J

    2014-01-01

    Five gradient concentrations (0.02, 0.04, 0.06, 0.08, and 0.10 g/mL) of leaching liquors from the roots, stems, and leaves of the invasive plant Bidens frondosa were used as conditioning fluid to examine its influence on seed germination conditions of the native plant Geum japonicum var. chinense in Huangshan. All leaching liquors of organs suppressed the seed germination of Geum japonicum var. chinense and reduced the final germination percentage and rate, and increased the germination inhibition rate, with a bimodal dependence on concentration. The leaching liquor inhibited the seed germination significantly at the concentration of 0.02 g/mL respectively. The seed germination was also inhibited as the concentration reached to 0.04 g/mL and beyond. Hence the allelopathic effects of the organs were significantly enhanced respectively. This phenomenon represented the presence of allelopathy substances in the root, stem and leaf of Bidens frondosa. PMID:25511044

  3. NASA Solve

    NASA Video Gallery

    NASA Solve lists opportunities available to the general public to contribute to solving tough problems related to NASA’s mission through challenges, prize competitions, and crowdsourcing activities...

  4. Purification, characterization and cloning of tensilin, the collagen-fibril binding and tissue-stiffening factor from Cucumaria frondosa dermis.

    PubMed

    Tipper, Jennifer P; Lyons-Levy, Gillian; Atkinson, Mark A L; Trotter, John A

    2002-12-01

    The inner dermis of the sea cucumber, Cucumaria frondosa, is a mutable collagenous tissue characterized by rapid and reversible changes in its mechanical properties regulated by one or more protein effectors that are released from neurosecretory cells. One such effector, tensilin, is a collagen-fibril binding protein, named for its ability to induce dermis stiffening. Tensilin was purified using an affinity column constructed from C. frondosa collagen-fibrils. The protein migrates as a single band on SDS-PAGE (Mr approximately 33 kDa) and has an isoelectric point of 5.8. Equilibrium sedimentation experiments suggest a molecular mass of approximately 28.5-29.4 kDa. Carbohydrate analysis of tensilin revealed no measurable sugar content. The molar amount of tensilin was determined to be 0.38% that of collagen and 47% that of stiparin, a constitutive matrix glycoprotein. A full-length cDNA clone for tensilin was obtained from a C. frondosa inner dermis cDNA expression library. Predicted properties derived from the deduced peptide sequence were in agreement with those of the native protein. A noted feature of tensilin's deduced peptide sequence, particularly in its N-terminal domain, is its homology to tissue inhibitor of metalloproteinases. Tensilin's C-terminal tail has no known homology to other proteins but contains a putative collagen-fibril binding site. PMID:12524049

  5. Compositional characteristics and antioxidant properties of fresh and processed sea cucumber (Cucumaria frondosa).

    PubMed

    Zhong, Ying; Khan, Muhammad Ahmad; Shahidi, Fereidoon

    2007-02-21

    The antioxidant activity of fresh and rehydrated sea cucumber (Cucumaria frondosa) samples with/without internal organs was evaluated for the first time. In addition, their proximate, amino acid, and fatty acid compositions were examined. Rehydrated sea cucumber samples in distilled water were prepared from oven-dried products. All samples contained 83-90% moisture, but showed a significant difference among groups in their protein and lipid contents. Glutamic acid was the predominant amino acid in sea cucumber, followed by glycine and aspartic acid. Essential amino acids such as leucine and lysine were also present at high levels. The trend for free amino acid was different from that of total amino acids and varied among groups. Lipids in sea cucumber were dominated by eicosapentaenoic acid (EPA, C20:5n-3), ranging from 43.2 to 56.7% of the total fatty acids. Docosahexaenoic acid (DHA, C22:6n-3) was present at a much lower concentration of 2.0-5.8%. All sea cucumber samples exhibited radical scavenging property against 2,2'-azobis(2-aminopropane) dihydrochloride (AAPH) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals, with rehydrated samples, especially those with internal organs, possessing higher antioxidant activity than their fresh counterparts. No correlation existed between radical scavenging capacity and total phenolics content, suggesting that other components, in addition to phenolic compounds, contribute to the antioxidant activity of sea cucumber. PMID:17243707

  6. Solving Quartics

    ERIC Educational Resources Information Center

    Kulkarni, R. G.

    2007-01-01

    A technique is presented, which is different from the well-known Ferrari's method, to solve a general quartic equation. Formulae for the four roots of quartic are derived. A numerical example verifies the formulae obtained.

  7. Novel Use of PIT Tags in Sea Cucumbers: Promising Results with the Commercial Species Cucumaria frondosa.

    PubMed

    Gianasi, Bruno L; Verkaik, Katie; Hamel, Jean-François; Mercier, Annie

    2015-01-01

    The lack of a reliable and innocuous mark-recapture method has limited studies that would provide essential information for the management of commercial sea cucumbers. Tagging sea cucumbers is notoriously difficult because of their plastic nature and autolysis capacities. The markers that have so far been tested, mainly on or through the body wall, were either lost rapidly or had major drawbacks (e.g. suitable only for batch identification, requiring complex analysis, causing infections, necrosis, behavioural changes and mortality). The present study explored the efficacy of passive integrated transponder (PIT) tags for individually marking sea cucumbers by assessing retention rates and long-term side effects of tags inserted in previously unstudied tissues/organs. Individuals of the species Cucumaria frondosa were tagged in the body wall, aquapharyngeal bulb and at the base of the oral tentacles. They were monitored closely for evidence of stress, infection, change in feeding and spawning behaviour and tag retention rate. Implanting the tag in an oral tentacle to reach the hydrovascular system of the aquapharyngeal bulb achieved the best retention rates in full-size individuals: from a maximum of 92% after 30 days to 68% at the end of the experimental period (300 days). Efficacy was lower in smaller individuals (84% after 30 d and 42% after 300 d). Following a slight increase in cloacal movements for 15 h post tagging, no side effect was noted in sea cucumbers tagged in the aquapharyngeal bulb via the tentacles. Feeding and spawning behaviours were not affected and no signs of infections or abnormal cell development in the vicinity of the tags were observed. This study indicates that marking sea cucumbers with 8.2 mm long PIT tags implanted via the oral tentacle is an effective technique, yielding relatively high retention rates over long periods without any detectable physiological or behavioural effects. PMID:26011165

  8. Novel Use of PIT Tags in Sea Cucumbers: Promising Results with the Commercial Species Cucumaria frondosa

    PubMed Central

    Gianasi, Bruno L.; Verkaik, Katie; Hamel, Jean-François; Mercier, Annie

    2015-01-01

    The lack of a reliable and innocuous mark-recapture method has limited studies that would provide essential information for the management of commercial sea cucumbers. Tagging sea cucumbers is notoriously difficult because of their plastic nature and autolysis capacities. The markers that have so far been tested, mainly on or through the body wall, were either lost rapidly or had major drawbacks (e.g. suitable only for batch identification, requiring complex analysis, causing infections, necrosis, behavioural changes and mortality). The present study explored the efficacy of passive integrated transponder (PIT) tags for individually marking sea cucumbers by assessing retention rates and long-term side effects of tags inserted in previously unstudied tissues/organs. Individuals of the species Cucumaria frondosa were tagged in the body wall, aquapharyngeal bulb and at the base of the oral tentacles. They were monitored closely for evidence of stress, infection, change in feeding and spawning behaviour and tag retention rate. Implanting the tag in an oral tentacle to reach the hydrovascular system of the aquapharyngeal bulb achieved the best retention rates in full-size individuals: from a maximum of 92% after 30 days to 68% at the end of the experimental period (300 days). Efficacy was lower in smaller individuals (84% after 30 d and 42% after 300 d). Following a slight increase in cloacal movements for 15 h post tagging, no side effect was noted in sea cucumbers tagged in the aquapharyngeal bulb via the tentacles. Feeding and spawning behaviours were not affected and no signs of infections or abnormal cell development in the vicinity of the tags were observed. This study indicates that marking sea cucumbers with 8.2 mm long PIT tags implanted via the oral tentacle is an effective technique, yielding relatively high retention rates over long periods without any detectable physiological or behavioural effects. PMID:26011165

  9. Solving Triangles

    ERIC Educational Resources Information Center

    Jarrrett, Joscelyn

    2005-01-01

    This article discusses the four categories of triangles that are standard in most textbooks when "solving" triangles: (a) Given the lengths of two sides and the measure of an angle opposite one of the two given sides, (b) Given the lengths of two sides and the measure of the included angle, (c) Given the lengths of all three sides, d) Given the…

  10. In Vivo Anti-Cancer Mechanism of Low-Molecular-Weight Fucosylated Chondroitin Sulfate (LFCS) from Sea Cucumber Cucumaria frondosa.

    PubMed

    Liu, Xiaoxiao; Liu, Yong; Hao, Jiejie; Zhao, Xiaoliang; Lang, Yinzhi; Fan, Fei; Cai, Chao; Li, Guoyun; Zhang, Lijuan; Yu, Guangli

    2016-01-01

    The low-molecular-weight fucosylated chondroitin sulfate (LFCS) was prepared from native fucosylated chondroitin sulfate (FCS), which was extracted and isolated from sea cucumber Cucumaria frondosa, and the anti-cancer mechanism of LFCS on mouse Lewis lung carcinoma (LLC) was investigated. The results showed that LFCS remarkably inhibited LLC growth and metastasis in a dose-dependent manner. LFCS induced cell cycle arrest by increasing p53/p21 expression and apoptosis through activation of caspase-3 activity in LLC cells. Meanwhile, LFCS suppressed the expression of vascular endothelial growth factor (VEGF), increased the expression of tissue inhibitor of metalloproteinase-1 (TIMP-1) and downregulated the matrix metalloproteinases (MMPs) level. Furthermore, LFCS significantly suppressed the activation of ERK1/2/p38 MAPK/NF-κB pathway, which played a prime role in expression of MMPs. All of these data indicate LFCS may be used as anti-cancer drug candidates and deserve further study. PMID:27187337

  11. Structure of Sphingolipids From Sea Cucumber Cucumaria frondosa and Structure-Specific Cytotoxicity Against Human HepG2 Cells.

    PubMed

    Jia, Zicai; Song, Yu; Tao, Suyuan; Cong, Peixu; Wang, Xiaoxu; Xue, Changhu; Xu, Jie

    2016-03-01

    To investigate the relationship between structure and activity, three glucocerebroside series (CFC-1, CFC-2 and CFC-3), ceramides (CF-Cer) and long-chain bases (CF-LCB) of sea cucumber Cucumaria frondosa (C. frondosa) were isolated and evaluated in HepG2 cells. The molecular species of CFC-1, CFC-2 and CFC-3 and CF-Cer were identified using reversed-phase liquid chromatography with heated electrospray ionization coupled to high-resolution mass spectrometry (RPLC-HESI-HRMS), and determined on the basis of chemical and spectroscopic evidence: For the three glucocerebroside series, fatty acids (FA) were mainly saturated (18:0 and 22:0), monounsaturated (22:1, 23:1 and 24:1) and 2-hydroxyl FA (2-HFA) (23:1 h and 24:1 h), the structure of long-chain bases (LCB) were dihydroxy (d17:1, d18:1 and d18:2) and trihydroxy (t16:0 and t17:0), and the glycosylation was glucose; For CF-Cer, FA were primarily saturated (17:0) and monounsaturated (16:1 and 19:1), the structure of LCB were dihydroxy (d17:1 and d18:1), and trihydroxy (t16:0). The results of cell experiment indicated that all of three glucocerebroside series, CF-Cer and CF-LCB exhibited an inhibitory effects on cell proliferation. Moreover, CFC-3 was most effective in three glucocerebrosides to HepG-2 cell viability. The inhibition effect of CF-LCB was the strongest, and the inhibition effect of CF-Cer was much stronger than glucocerebrosides. PMID:26861868

  12. Protective effects of new medicinal mushroom, Grifola gargal singer (higher Basidiomycetes), on induced DNA damage in somatic cells of Drosophila melanogaster.

    PubMed

    Postemsky, Pablo Daniel; Palermo, Ana Maria; Curvetto, Néstor Raúl

    2011-01-01

    Grifola gargal is an edible mushroom with attributed antioxidant properties. Different sources of G. gargal materials, i.e., fruit bodies and mycelia grown in liquid or solid media, were used to study its potential protective capacity when somatic mutation and recombination is induced in Drosophila melanogaster using DMBA (7-12-dimethyl-benz(α)anthracene) as promutagen. Heterozygote larvae (white/white+) were grown in media with different concentrations of DMBA. Grifola gargal fruit bodies (GgFB) or mycelia from liquid culture (GgLC) or from solid culture (GgWG), i.e., biotransformed wheat kernel flour, were added to the culture media in combined treatments with DMBA. Water, DMBA solvent, or wheat flour (WF) plus DMBA solvent were used as negative controls. Larval mortality increased from 9% to 11% in negative controls to 31% to 36% in DMBA treatments. The addition of GgFB, GgLC, or GgWG materials produced a protective effect on 25 μmol/vial DMBA-induced mortality. Mutations observed in SMART, as light spots per 100 eyes (LS/100 eyes), increased with increasing doses of DMBA; this was also true when considering the mutation incidence expressed as percentage of eyes exhibiting light spots (% eyes with LS). Interestingly, mycelia from GgFB, GgLC, or GgWG, in the presence of 25 μmol/vial DMBA, showed lower values in SMART of both the total LS/100 eyes and the percentage of eyes with LS. Thus, Grifola gargal materials were not only nontoxic, but in combination with 25 μmol/vial DMBA lowered the mortality induced by the promutagen and showed antimutagenic effects. Protective effects of G. gargal against DMBA are discussed in terms of the onset of desmutagenic and/or bioantimutagenic mechanisms of detoxification in the host organism, probably due to some bioactive compounds known to occur in higher mushrooms. PMID:22181846

  13. Immunomodulatory properties of frondoside A, a major triterpene glycoside from the North Atlantic commercially harvested sea cucumber Cucumaria frondosa.

    PubMed

    Aminin, D L; Agafonova, I G; Kalinin, V I; Silchenko, A S; Avilov, S A; Stonik, V A; Collin, P D; Woodward, C

    2008-09-01

    Frondoside A, a major triterpene glycoside from North Atlantic commercially harvested sea cucumber Cucumaria frondosa, possesses strong immunomodulatory properties in subtoxic doses. Frondoside A stimulates lysosomal activity of mouse macrophages in vivo at a maximal effective stimulatory dose of 0.2 microg per mouse and is maintained over 10 days. This glycoside also shows a 30% stimulation of lysosomal activity in mouse macrophages in vitro at concentrations of 0.1-0.38 microg/mL. Frondoside A enhances macrophage phagocytosis of the bacterium Staphylococcus aureus in vitro at a maximal effective concentration of 0.001 microg/mL. Frondoside A stimulates reactive oxygen species formation in macrophages in vitro at a maximal effective concentration of 0.001 microg/mL. Frondoside A stimulates an increase in the number of antibody plaque-forming cells (normally B-cells in spleen) in vivo with a maximal stimulatory effect at a concentration of 0.2 microg per mouse (stimulatory index, 1.86). Frondoside A has a weak effect upon immunoglobulin (Ig) M production after immunization with sheep erythrocytes in mice. Frondoside A does not stimulate Ig production in mice and does not significantly enhance the ovalbumin-stimulated IgM and IgG antibody levels in ovalbumin-immunized mice. Hence frondoside A is an immunostimulant of cell-based immunity including phagocytosis without a significant effect on amplification of humoral immune activity or adjuvant properties. Therefore, frondoside A may provide curative and/or preventive treatment options against diseases wherein a depleted immune status contributes to the pathological processes. PMID:18800890

  14. TRAINING IN PROBLEM SOLVING.

    ERIC Educational Resources Information Center

    DEVANE, J.R.; RIMOLDI, H.J.A.

    CHANGES WERE STUDIED IN THE PROBLEM-SOLVING BEHAVIOR OF HIGH SCHOOL STUDENTS AS A FUNCTION OF A CAREFULLY DESIGNED TRAINING PROGRAM. TRAINING WAS DEFINED AS THE DEVELOPMENT OF STUDENT AWARENESS OF PROBLEM-SOLVING STRATEGIES USED. INSTRUMENTS WERE DEVELOPED AND REFINED TO MEASURE PROBLEM-SOLVING BEHAVIOR. SPECIFICALLY TESTED WAS THE FOLLOWING…

  15. Isolation of cytotoxic glucoerebrosides and long-chain bases from sea cucumber Cucumaria frondosa using high speed counter-current chromatography.

    PubMed

    Xu, Jie; Guo, Shuang; Du, Lei; Wang, Yu-Ming; Sugawara, Tatsuya; Hirata, Takashi; Xue, Chang-Hu

    2013-01-01

    Total glucocerebrosides of the sea cucumber Cucumaria frondosa (CFC) have been isolated from the less polar lipid fraction of the chloroform-methanol extract using high speed counter-current chromatography (HSCCC) with a two-phase solvent system composed of petroleum ether-methanol-water (5:4:1, v/v). Three glucocerebroside molecular species (CFC-1, CFC-2 and CFC-3) were isolated from crude total cerebrosides with repeated column chromatography. The structures of these three glucocerebroside molecular species were determined on the basis of chemical and spectroscopic evidence: fatty acids were mainly saturated (C22:0 and C18:0), monounsaturated (C24:1 and C20:1) and α-hydroxyl fatty acids (C24:1h, C23:0h, C23:1h and C22:0h), the structures of long-chain bases were dihydroxy (d17:1, d18:2 and d18:1) and trihydroxy (t17:0 and t16:0), and the glycosylation was glucose. High purity long-chain bases of sea cucumber Cucumaria frondosa (CF-LCB) were prepared from total lipids by HSCCC with a two-phase solvent system composed of n-hexane-methyl tert butyl ether-methanol-water (1:1:2:1, v/v). Compare with traditional preparative methods, the method of HSCCC is short cycle, high yield and less solvent consumption. The composition analysis of CF-LCB showed that the ratio of d18:2 and d17:1 was approximately 2:1. The four glucocerebrosides and long-chain bases from sea cucumber Cucumaria frondosa were evaluated for activity in vitro assays for the cytotoxic activities against Caco-2 colon cancer cells. The results indicated that both glucocerebrosides and long-chain bases exhibited an inhibitory effect on cell proliferation. Moreover, CFC-3 was most effective in four glucocerebrosides to Caco-2 cell viability. The inhibition effect of CF-LCB was much stronger than glucocerebrosides. PMID:23470440

  16. Teaching through Problem Solving

    ERIC Educational Resources Information Center

    Fi, Cos D.; Degner, Katherine M.

    2012-01-01

    Teaching through Problem Solving (TtPS) is an effective way to teach mathematics "for" understanding. It also provides students with a way to learn mathematics "with" understanding. In this article, the authors present a definition of what it means to teach through problem solving. They also describe a professional development vignette that…

  17. Chemical Reaction Problem Solving.

    ERIC Educational Resources Information Center

    Veal, William

    1999-01-01

    Discusses the role of chemical-equation problem solving in helping students predict reaction products. Methods for helping students learn this process must be taught to students and future teachers by using pedagogical skills within the content of chemistry. Emphasizes that solving chemical reactions should involve creative cognition where…

  18. Problem Solving in Nursing.

    ERIC Educational Resources Information Center

    Karns, Phyllis Spear

    The relationship of educational preparation to the problem- solving performance of 55 hospital employed baccalaureate and associate degree nurses working in Wyoming hospitals was studied. Participant data were collected that might correlate with problem-solving ability: age, years of experience in nursing, years of work experience in a…

  19. Problem Solving and Intelligence.

    ERIC Educational Resources Information Center

    Resnick, Lauren B.; Glaser, Robert

    This paper argues that a major aspect of intelligence is the ability to solve problems and that careful analysis of problem-solving behavior is a means of specifying many of the psychological processes that make up intelligence. The focus is on the mechanisms involved when, in the absence of complete instruction, a person must "invent" a new…

  20. Techniques of Problem Solving.

    ERIC Educational Resources Information Center

    Krantz, Steven G.

    The purpose of this book is to teach the basic principles of problem solving in both mathematical and non-mathematical problems. The major components of the book consist of learning to translate verbal discussion into analytical data, learning problem solving methods for attacking collections of analytical questions or data, and building a…

  1. Effect of the Medicinal Mushroom, Grifola gargal (Agaricomycetes), on Bone Turnover Markers and Serum Lipids in Middle-Aged and Elderly Japanese Women.

    PubMed

    Harada, Etsuko; Morizono, Toshihiro; Sumiya, Toshimitsu; Kawagishi, Hirokazu

    2016-01-01

    A clinical study was performed to examine the effect of the edible mushroom, Grifola gargal, on bone turnover markers and serum lipids in middle-aged and elderly Japanese women. Postmenopausal women aged 51-73 years (mean age, 61 years) received daily oral administration of 5 g G. gargal fruiting bodies (hot air-dried and powdered; G. gargal powder [GGP]). Serum levels of bone alkaline phosphatase (BAP) and lipids and urinary deoxypyridinoline (DPD) levels were measured before and 2 weeks after the start of GGP treatment. As a result, urinary DPD bone resorption marker levels in women treated with GGP decreased significantly. Serum levels of the BAP bone formation marker also tended to increase, but the difference was not significant. By contrast, the atherogenic index decreased and the high-density lipoprotein (HDL) ratio increased significantly. However, there were no statistically significant differences in serum lipids of total cholesterol, HDL cholesterol, and low-density lipoprotein cholesterol. In addition, this study demonstrated for the first time that G. gargal is safe for human consumption. PMID:27279439

  2. NAEP Note: Problem Solving.

    ERIC Educational Resources Information Center

    Carpenter, Thomas P.; And Others

    1980-01-01

    Student weaknesses on problem-solving portions of the NAEP mathematics assessment are discussed using Polya's heuristics as a framework. Recommendations for classroom instruction are discussed. (MP) Aspect of National Assessment (NAEP) dealt with in this document: Results (Interpretation).

  3. Solving Tommy's Writing Problems.

    ERIC Educational Resources Information Center

    Burdman, Debra

    1986-01-01

    The article describes an approach by which word processing helps to solve some of the writing problems of learning disabled students. Aspects considered include prewriting, drafting, revising, and completing the story. (CL)

  4. Solving Word Problems.

    ERIC Educational Resources Information Center

    Karrison, Joan; Carroll, Margaret Kelly

    1991-01-01

    Students with language and learning disabilities may have difficulty solving mathematics word problems. Use of a sequential checklist, identifying clues and keywords, and illustrating a problem can all help the student identify and implement the correct computational process. (DB)

  5. Problem-Solving Software

    NASA Technical Reports Server (NTRS)

    1992-01-01

    CBR Express software solves problems by adapting sorted solutions to new problems specified by a user. It is applicable to a wide range of situations. The technology was originally developed by Inference Corporation for Johnson Space Center's Advanced Software Development Workstation. The project focused on the reuse of software designs, and Inference used CBR as part of the ACCESS prototype software. The commercial CBR Express is used as a "help desk" for customer support, enabling reuse of existing information when necessary. It has been adopted by several companies, among them American Airlines, which uses it to solve reservation system software problems.

  6. What Is Problem Solving?

    ERIC Educational Resources Information Center

    Martinez, Michael E.

    1998-01-01

    Many important human activities involve accomplishing goals without a script. There is no formula for true problem-solving. Heuristic, cognitive "rules of thumb" are the problem-solver's best guide. Learners should understand heuristic tools such as means-end analysis, working backwards, successive approximation, and external representation. Since…

  7. Inquiry and Problem Solving.

    ERIC Educational Resources Information Center

    Thorson, Annette, Ed.

    1999-01-01

    This issue of ENC Focus focuses on the topic of inquiry and problem solving. Featured articles include: (1) "Inquiry in the Everyday World of Schools" (Ronald D. Anderson); (2) "In the Cascade Reservoir Restoration Project Students Tackle Real-World Problems" (Clint Kennedy with Advanced Biology Students from Cascade High School); (3) "Project…

  8. [Problem Solving Activities.

    ERIC Educational Resources Information Center

    Wisconsin Univ. - Stout, Menomonie. Center for Vocational, Technical and Adult Education.

    The teacher directed problem solving activities package contains 17 units: Future Community Design, Let's Build an Elevator, Let's Construct a Catapult, Let's Design a Recreational Game, Let's Make a Hand Fishing Reel, Let's Make a Wall Hanging, Let's Make a Yo-Yo, Marooned in the Past, Metrication, Mousetrap Vehicles, The Multi System…

  9. On Solving Linear Recurrences

    ERIC Educational Resources Information Center

    Dobbs, David E.

    2013-01-01

    A direct method is given for solving first-order linear recurrences with constant coefficients. The limiting value of that solution is studied as "n to infinity." This classroom note could serve as enrichment material for the typical introductory course on discrete mathematics that follows a calculus course.

  10. Electric Current Solves Mazes

    ERIC Educational Resources Information Center

    Ayrinhac, Simon

    2014-01-01

    We present in this work a demonstration of the maze-solving problem with electricity. Electric current flowing in a maze as a printed circuit produces Joule heating and the right way is instantaneously revealed with infrared thermal imaging. The basic properties of electric current can be discussed in this context, with this challenging question:…

  11. Solving Problems in Genetics

    ERIC Educational Resources Information Center

    Aznar, Mercedes Martinez; Orcajo, Teresa Ibanez

    2005-01-01

    A teaching unit on genetics and human inheritance using problem-solving methodology was undertaken with fourth-level Spanish Secondary Education students (15 year olds). The goal was to study certain aspects of the students' learning process (concepts, procedures and attitude) when using this methodology in the school environment. The change…

  12. Problem Solving Using Calculators.

    ERIC Educational Resources Information Center

    Billings, Karen; Moursund, David

    1978-01-01

    The first part in the serialized version of a book on the use of calculators for problem solving is presented. It contains prefaces for teachers and students and a chapter on getting started which includes topics such as symmetries, operations, powers, and chaining. (MP)

  13. Solving Common Mathematical Problems

    NASA Technical Reports Server (NTRS)

    Luz, Paul L.

    2005-01-01

    Mathematical Solutions Toolset is a collection of five software programs that rapidly solve some common mathematical problems. The programs consist of a set of Microsoft Excel worksheets. The programs provide for entry of input data and display of output data in a user-friendly, menu-driven format, and for automatic execution once the input data has been entered.

  14. Universal Design Problem Solving

    ERIC Educational Resources Information Center

    Sterling, Mary C.

    2004-01-01

    Universal design is made up of four elements: accessibility, adaptability, aesthetics, and affordability. This article addresses the concept of universal design problem solving through experiential learning for an interior design studio course in postsecondary education. Students' experiences with clients over age 55 promoted an understanding of…

  15. Problem Solving with Patents

    ERIC Educational Resources Information Center

    Moore, Jerilou; Sumrall, William J.

    2008-01-01

    Exploring our patent system is a great way to engage students in creative problem solving. As a result, the authors designed a teaching unit that uses the study of patents to explore one avenue in which scientists and engineers do science. Specifically, through the development of an idea, students learn how science and technology are connected.…

  16. Solving Problems through Circles

    ERIC Educational Resources Information Center

    Grahamslaw, Laura; Henson, Lisa H.

    2015-01-01

    Several problem-solving interventions that utilise a "circle" approach have been applied within the field of educational psychology, for example, Circle Time, Circle of Friends, Sharing Circles, Circle of Adults and Solution Circles. This research explored two interventions, Solution Circles and Circle of Adults, and used thematic…

  17. Problem Solving Techniques Seminar.

    ERIC Educational Resources Information Center

    Massachusetts Career Development Inst., Springfield.

    This booklet is one of six texts from a workplace literacy curriculum designed to assist learners in facing the increased demands of the workplace. Six problem-solving techniques are developed in the booklet to assist individuals and groups in making better decisions: problem identification, data gathering, data analysis, solution analysis,…

  18. Problem Solving in Electricity.

    ERIC Educational Resources Information Center

    Caillot, Michel; Chalouhi, Elias

    Two studies were conducted to describe how students perform direct current (D-C) circuit problems. It was hypothesized that problem solving in the electricity domain depends largely on good visual processing of the circuit diagram and that this processing depends on the ability to recognize when two or more electrical components are in series or…

  19. Circumference and Problem Solving.

    ERIC Educational Resources Information Center

    Blackburn, Katie; White, David

    The concept of pi is one of great importance to all developed civilization and one that can be explored and mastered by elementary students through an inductive and problem-solving approach. Such an approach is outlined and discussed. The approach involves the following biblical quotation: "And he made a moltin sea ten cubits from one brim to the…

  20. Problem Solving by Design

    ERIC Educational Resources Information Center

    Capobianco, Brenda M.; Tyrie, Nancy

    2009-01-01

    In a unique school-university partnership, methods students collaborated with fifth graders to use the engineering design process to build their problem-solving skills. By placing the problem in the context of a client having particular needs, the problem took on a real-world appeal that students found intriguing and inviting. In this article, the…

  1. Mathematics as Problem Solving.

    ERIC Educational Resources Information Center

    Soifer, Alexander

    This book contains about 200 problems. It is suggested that it be used by students, teachers or anyone interested in exploring mathematics. In addition to a general discussion on problem solving, there are problems concerned with number theory, algebra, geometry, and combinatorics. (PK)

  2. Fucoidan from sea cucumber Cucumaria frondosa exhibits anti-hyperglycemic effects in insulin resistant mice via activating the PI3K/PKB pathway and GLUT4.

    PubMed

    Wang, Yiming; Wang, Jingfeng; Zhao, Yanlei; Hu, Shiwei; Shi, Di; Xue, Changhu

    2016-01-01

    The present study investigated the anti-hyperglycemic properties and mechanisms of fucoidan, isolated from Cucumaria frondosa (Cf-FUC), in insulin resistant mice. Male C57BL/6J mice were fed regular diet or high-fat/high-sucrose diet for 19 weeks. Model animals were dietary administrated either rosiglitazone (RSG, 1 mg/kg·bw), fucoidan (Cf-FUC, 80 mg/kg·bw) or their combinations. Results showed that Cf-FUC significantly reduced fasting blood glucose and insulin levels, and enhanced glucose tolerance and insulin tolerance in insulin-resistant mice. Quantitative real-time PCR analysis showed that Cf-FUC increased the mRNA expressions of insulin receptors (IR), insulin receptor substrate 1 (IRS-1), phosphatidylinositol 3 kinase (PI3K), protein kinase B (PKB), and glucose transporter 4 (GLUT4). Western blot assays demonstrated that Cf-FUC showed no effect on total protein expression but nevertheless enhanced the phosphorylation of proteins listed above and increased translocation of GLUT4 to the cell membrane. Furthermore, Cf-FUC enhanced the effects of RSG. These results indicated that Cf-FUC exhibited significant anti-hyperglycemic effects via activating PI3K/PKB pathway and GLUT4 in skeletal muscle and adipose tissue. PMID:26194305

  3. Cytotoxic and apoptosis-inducing activity of triterpene glycosides from Holothuria scabra and Cucumaria frondosa against HepG2 cells.

    PubMed

    Wang, Juanjuan; Han, Hua; Chen, Xiangfeng; Yi, Yanghua; Sun, Hongxiang

    2014-08-01

    The cytotoxic effects of thirteen triterpene glycosides from Holothuria scabra Jaeger and Cucumaria frondosa Gunnerus (Holothuroidea) against four human cell lines were detected and their cytotoxicity-structure relationships were established. The apoptosis-inducing activity of a more potent glycoside echinoside A (1) in HepG2 cells was further investigated by determining its effect on the morphology, mitochondrial transmembrane potential (Δψm) and mRNA expression levels of the apoptosis-related genes. The results showed that the number of glycosyl residues in sugar chains and the side chain of aglycone could affect their cytotoxicity towards tumor cells and selective cytotoxicity. 1 significantly inhibited cell viability and induced apoptosis in HepG2 cells. 1 also markedly decreased the Δψm and Bcl-2/Bax mRNA express ratio, and up-regulated the mRNA expression levels of Caspase-3, Caspase-8 and Caspase-9 in HepG2 cells. Therefore, 1 induced apoptosis in HepG2 cells through both intrinsic and extrinsic pathway. These findings could potentially promote the usage of these glycosides as leading compounds for developing new antitumor drugs. PMID:25062508

  4. Cytotoxic and Apoptosis-Inducing Activity of Triterpene Glycosides from Holothuria scabra and Cucumaria frondosa against HepG2 Cells

    PubMed Central

    Wang, Juanjuan; Han, Hua; Chen, Xiangfeng; Yi, Yanghua; Sun, Hongxiang

    2014-01-01

    The cytotoxic effects of thirteen triterpene glycosides from Holothuria scabra Jaeger and Cucumaria frondosa Gunnerus (Holothuroidea) against four human cell lines were detected and their cytotoxicity-structure relationships were established. The apoptosis-inducing activity of a more potent glycoside echinoside A (1) in HepG2 cells was further investigated by determining its effect on the morphology, mitochondrial transmembrane potential (Δψm) and mRNA expression levels of the apoptosis-related genes. The results showed that the number of glycosyl residues in sugar chains and the side chain of aglycone could affect their cytotoxicity towards tumor cells and selective cytotoxicity. 1 significantly inhibited cell viability and induced apoptosis in HepG2 cells. 1 also markedly decreased the Δψm and Bcl-2/Bax mRNA express ratio, and up-regulated the mRNA expression levels of Caspase-3, Caspase-8 and Caspase-9 in HepG2 cells. Therefore, 1 induced apoptosis in HepG2 cells through both intrinsic and extrinsic pathway. These findings could potentially promote the usage of these glycosides as leading compounds for developing new antitumor drugs. PMID:25062508

  5. The WNT/β-catenin pathway is involved in the anti-adipogenic activity of cerebrosides from the sea cucumber Cucumaria frondosa.

    PubMed

    Xu, Hui; Wang, Fei; Wang, Jingfeng; Xu, Jie; Wang, Yuming; Xue, Changhu

    2015-07-01

    Both adipocyte hypertrophy and hyperplasia lead to obesity. Here, we isolated cerebrosides from the sea cucumber Cucumaria frondosa (CFC) and examined its anti-adipogenic activity in vitro. CFC inhibited the lipid accumulation of 3T3-L1 cells and suppressed PPARγ and C/EBPα expressions, proving its anti-adipogenic activity. Furthermore, CFC suppressed lipogenesis in mature adipocytes. The WNT/β-catenin pathway acts as an anti-adipogenic factor. CFC enhanced β-catenin expression, promoted its nuclear translocation and up-regulated the expression of CCND1 and c-myc, two target genes of β-catenin. Moreover, after cells were treated with the β-catenin inhibitor 21H7, β-catenin nuclear translocation and transcription activity can be recovered by CFC. These findings suggested that CFC promoted the activation of the WNT/β-catenin pathway. Besides, CFC enhanced the expressions of Fz1, LRP5 and LRP6, while it had no effect on the expressions of Wnt10b and GSK3β. These findings indicated that CFC exhibits anti-adipogenic activity through enhancing the activation of the WNT/β-catenin pathway, which was mediated by FZ and LRPs. PMID:26091058

  6. Electric current solves mazes

    NASA Astrophysics Data System (ADS)

    Ayrinhac, Simon

    2014-07-01

    We present in this work a demonstration of the maze-solving problem with electricity. Electric current flowing in a maze as a printed circuit produces Joule heating and the right way is instantaneously revealed with infrared thermal imaging. The basic properties of electric current can be discussed in this context, with this challenging question: how can the electric current choose the right way and avoid dead ends?

  7. Solving crimes with hypnosis.

    PubMed

    Wester, William C; Hammond, D Corydon

    2011-04-01

    Following a brief review of the literature on hypnosis and memory, this paper overviews the procedures that are used in conducting forensic hypnosis interviews. Ten forensic hypnosis cases are then described. These real world cases are in stark contrast to research done in an artificial laboratory setting where the information to be recalled lacks personal relevance and was not associated with emotionally arousing situations. These cases illustrate how forensic hypnosis can result in obtaining important additional investigative leads which lead to the solving of crimes. PMID:21598840

  8. Eicosapentaenoic acid-enriched phosphatidylcholine isolated from Cucumaria frondosa exhibits anti-hyperglycemic effects via activating phosphoinositide 3-kinase/protein kinase B signal pathway.

    PubMed

    Hu, Shiwei; Xu, Leilei; Shi, Di; Wang, Jingfeng; Wang, Yuming; Lou, Qiaoming; Xue, Changhu

    2014-04-01

    Eicosapentaenoic acid-enriched phosphatidylcholine was isolated from the sea cucumber Cucumaria frondosa (Cucumaria-PC) and its effects on streptozotocin (STZ)-induced hyperglycemic rats were investigated. Male Sprague-Dawley rats were randomly divided into normal control, model control (STZ), low- and high-dose Cucumaria-PC groups (STZ + Cucumaria-PC at 25 and 75 mg/Kg·b·wt, intragastrically, respectively). Blood glucose, insulin, glycogen in liver and gastrocnemius were determined over 60 days. Insulin signaling in the rats' gastrocnemius was determined by reverse transcriptase-polymerase chain reaction (RT-PCR) and Western blotting. The results showed that Cucumaria-PC significantly decreased blood glucose level, increased insulin secretion and glycogen synthesis in diabetic rats. RT-PCR analysis revealed that Cucumaria-PC significantly promoted the expressions of glycometabolism-related genes of insulin receptor (IR), insulin receptor substrate-1 (IRS-1), phosphoinositide 3-kinase (PI3K), protein kinase B (PKB), and glucose transporter 4 (GLUT4) in gastrocnemius. Western blotting assay demonstrated that Cucumaria-PC remarkably enhanced the proteins abundance of IR-β, PI3K, PKB, GLUT4, as well as phosphorylation of Tyr-IR-β, p85-PI3K, Ser473-PKB (P < 0.05 and P < 0.01). These findings suggested that Cucumaria-PC exhibited significant anti-hyperglycemic activities through up-regulating PI3K/PKB signal pathway mediated by insulin. Nutritional supplementation with Cucumaria-PC, if validated for human studies, may offer an adjunctive therapy for diabetes mellitus. PMID:24168893

  9. The protective effect of eicosapentaenoic acid-enriched phospholipids from sea cucumber Cucumaria frondosa on oxidative stress in PC12 cells and SAMP8 mice.

    PubMed

    Wu, Feng-Juan; Xue, Yong; Liu, Xiao-Fang; Xue, Chang-Hu; Wang, Jing-Feng; Du, Lei; Takahashi, Koretaro; Wang, Yu-Ming

    2014-01-01

    Alzheimer's disease (AD) is a common neurodegenerative disorders, in which oxidative stress plays an important role. The present study investigated the effect of eicosapentaenoic acid-enriched phospholipids (EPA-enriched PL) from the sea cucumber Cucumaria frondosa on oxidative injury in PC12 cells induced by hydrogen peroxide (H2O2) and tert-butylhydroperoxide (t-BHP). We also studied the effect of EPA-enriched PL on learning and memory functions in senescence-accelerated prone mouse strain 8 (SAMP8) in vivo. Pretreatment with EPA-enriched PL resulted in an enhancement of survival in a dose-dependent manner in H2O2 or t-BHP damaged PC12 cells. EPA-enriched PL pretreatment could also reduce the leakage of lactate dehydrogenase (LDH), and increase the intracellular total antioxidant capacity (T-AOC) and superoxide dismutase (SOD) activity compared with the H2O2 or t-BHP group. The down-regulated Bcl-2 mRNA level and up-regulated Bax, Caspase-9, and Caspase-3 mRNA expression induced by H2O2 or t-BHP could be restored by EPA-enriched PL pretreatment. These results demonstrated that EPA-enriched PL exhibited its neuroprotective effects by virtue of its antioxidant activity, which might be achieved by inhibiting the mitochondria-dependent apoptotic pathway. The neuroprotective effect of EPA-enriched PL was also verified in vivo test: the EPA-enriched PL administration prevented the development of learning and memory impairments in SAMP8 mice. Our results indicated that EPA-enriched PL could offer an efficient and novel strategy to explore novel drugs or functional food for neuronprotection and cognitive improvement. PMID:24231470

  10. Solving Differential Equations in R: Package deSolve

    EPA Science Inventory

    In this paper we present the R package deSolve to solve initial value problems (IVP) written as ordinary differential equations (ODE), differential algebraic equations (DAE) of index 0 or 1 and partial differential equations (PDE), the latter solved using the method of lines appr...

  11. Solving Quasars (Part 1)

    SciTech Connect

    Elvis, Martin

    2003-10-29

    Quasars are a frustratingly unsolved problem in astrophysics. For 40 years quasars and AGN have presented an ever-proliferating list of diverse and confusing phenomenology from optical to X-ray wavelengths. The result has been that despite being the most powerful objects in the universe, quasars have been increasingly sidelined in astrophysics. This is unfortunate, as quasars pose major physics, as well as astrophysics puzzles, and should be important in cosmology. The problem, I believe, is not that we do not know enough physics, but rather that we do not have the right geometry. I have proposed a simple geometric and kinematic model that allows all of the quasar diversity to be understood as part of a single structure, the 'Quasar Atmosphere'. This structure suggests a natural physical interpretation, that builds on our understanding of stars (the only fully solved problem in astrophysics), and offers the prospect that we can use quasars for cosmology at last.

  12. The Problem-Solving Revolution.

    ERIC Educational Resources Information Center

    Bardige, Art

    1983-01-01

    Discusses the use of microcomputers and software as problem-solving tools, including comments on "TK! Solver," automatic problem-solving program (reviewed in detail on pp.84-86 in this same issue). Also discusses problem-solving approaches to bridge the disciplines, such as music/physics, junior high science/mathematics (genetics),…

  13. The Identity of Problem Solving

    ERIC Educational Resources Information Center

    Mamona-Downs, Joanna; Downs, Martin

    2005-01-01

    This paper raises issues motivated by considering the "identity" of problem solving. This means that we are concerned with how other mathematics education topics impinge on problem solving, and with themes that naturally arise within the problem-solving agenda. We claim that some of these issues need more attention by educational research, while…

  14. Solving the Antibiotic Crisis.

    PubMed

    Wright, Gerard D

    2015-02-13

    Antibiotics are essential for both treating and preventing infectious diseases. Paradoxically, despite their importance as pillars of modern medicine, we are in danger of losing antibiotics because of the evolution and dissemination of resistance mechanisms throughout all pathogenic microbes. This fact, coupled with an inability to bring new drugs to market at a pace that matches resistance, has resulted in a crisis of global proportion. Solving this crisis requires the actions of many stakeholders, but chemists, chemical biologists, and microbiologists must drive the scientific innovation that is required to maintain our antibiotic arsenal. This innovation requires (1) a deep understanding of the evolution and reservoirs of resistance; (2) full knowledge of the molecular mechanisms of antibiotic action and resistance; (3) the discovery of chemical and genetic probes of antibiotic action and resistance; (4) the integration of systems biology into antibiotic discovery; and (5) the discovery of new antimicrobial chemical matter. Addressing these pressing scientific gaps will ensure that we can meet the antibiotic crisis with creativity and purpose. PMID:27622298

  15. Computer Problem-Solving Coaches

    NASA Astrophysics Data System (ADS)

    Hsu, Leon; Heller, Kenneth

    2005-09-01

    Computers might be able to play an important role in physics instruction by coaching students to develop good problem-solving skills. Building on previous research on student problem solving and on designing computer programs to teach cognitive skills, we are developing a prototype computer coach to provide students with guided practice in solving problems. In addition to helping students become better problem solvers, such programs can be useful in studying how students learn to solve problems and how and if problem-solving skills can be transferred from a computer to a pencil-and-paper environment.

  16. Chemopreventive effects of Frondanol A5, a Cucumaria frondosa extract, against rat colon carcinogenesis and inhibition of human colon cancer cell growth.

    PubMed

    Janakiram, Naveena B; Mohammed, Altaf; Zhang, Yuting; Choi, Chang-In; Woodward, Carl; Collin, Peter; Steele, Vernon E; Rao, Chinthalapally V

    2010-01-01

    Sea cucumber extracts have been widely used to treat individuals with inflammatory conditions in East Asia. The present study has been designed to test potential colon cancer-preventive properties of Frondanol A5, a glycolipid extract from the sea cucumber, Cucumaria frondosa, using in vivo and in vitro models of colon cancer. Chemopreventive efficacy of Frondanol A5 was evaluated on azoxymethane-induced rat colon carcinogenesis using colonic aberrant crypt foci (ACF) as efficacy marker. At 7 weeks of age, groups of rats (12 per group) were fed the AIN-76A diet, and ACFs were induced by azoxymethane (15 mg/kg body weight). Three days after azoxymethane treatment, rats were fed with the diets containing 0, 150, and 450 ppm of Frondanol A5 and continued on the diets for 8 weeks, at which time ACFs were evaluated. Expression levels of proliferating cell nuclear antigen and p21(WAF1/CIP1) were determined in ACFs. Further, Frondanol A5 (10-120 microg/mL) was studied for its growth-inhibitory and apoptotic effects in the HCT-116 cell line. Dietary administration of 150 and 450 ppm of Frondanol A5 significantly suppressed azoxymethane-induced total colonic ACF formation, approximately 34% to 55% (P < 0.01 to P < 0.0001), and multicrypt aberrant foci (48-68.5%, P < 0.0001) in a dose-dependent manner. ACFs in rats treated with Frondanol A5 showed significant upregulation of p21(WAF1/CIP1) and downregulation of proliferating cell nuclear antigen compared with control group. Frondanol A5 showed growth inhibition at S and G(2)-M phase with a decrease in Cdc25c and an increase in p21(WAF1/CIP) with significant apoptosis associated with H2AX phosphorylation and caspase-2 cleavage in HCT116 cells. Overall, Frondanol A5 exhibits potential chemopreventive properties for colon carcinogenesis, which suggests further development of this sea cucumber extract. PMID:20051375

  17. Parent Problem Solving: Analysis of Problem Solving in Parenthood Transition.

    ERIC Educational Resources Information Center

    Alpert, Judith L.; And Others

    The general purpose of this study was to explore the possibility of adapting the Means-Ends Problem-Solving procedure (MEPS) to the investigation of the individual's transition to parenthood. Specific purposes were to determine (1) the internal consistency of the Parent Problem-Solving Scale (PPSS), of its subclasses, and of a combined subscale;…

  18. Pulsating Star Mystery Solved

    NASA Astrophysics Data System (ADS)

    2010-11-01

    By discovering the first double star where a pulsating Cepheid variable and another star pass in front of one another, an international team of astronomers has solved a decades-old mystery. The rare alignment of the orbits of the two stars in the double star system has allowed a measurement of the Cepheid mass with unprecedented accuracy. Up to now astronomers had two incompatible theoretical predictions of Cepheid masses. The new result shows that the prediction from stellar pulsation theory is spot on, while the prediction from stellar evolution theory is at odds with the new observations. The new results, from a team led by Grzegorz Pietrzyński (Universidad de Concepción, Chile, Obserwatorium Astronomiczne Uniwersytetu Warszawskiego, Poland), appear in the 25 November 2010 edition of the journal Nature. Grzegorz Pietrzyński introduces this remarkable result: "By using the HARPS instrument on the 3.6-metre telescope at ESO's La Silla Observatory in Chile, along with other telescopes, we have measured the mass of a Cepheid with an accuracy far greater than any earlier estimates. This new result allows us to immediately see which of the two competing theories predicting the masses of Cepheids is correct." Classical Cepheid Variables, usually called just Cepheids, are unstable stars that are larger and much brighter than the Sun [1]. They expand and contract in a regular way, taking anything from a few days to months to complete the cycle. The time taken to brighten and grow fainter again is longer for stars that are more luminous and shorter for the dimmer ones. This remarkably precise relationship makes the study of Cepheids one of the most effective ways to measure the distances to nearby galaxies and from there to map out the scale of the whole Universe [2]. Unfortunately, despite their importance, Cepheids are not fully understood. Predictions of their masses derived from the theory of pulsating stars are 20-30% less than predictions from the theory of the

  19. Problem Solving in the Professions.

    ERIC Educational Resources Information Center

    Jackling, Noel; And Others

    1990-01-01

    It is proposed that algorithms and heuristics are useful in improving professional problem-solving abilities when contextualized within the academic discipline. A basic algorithm applied to problem solving in undergraduate engineering education and a similar algorithm applicable to legal problems are used as examples. Problem complexity and…

  20. Problem Solving vis Soap Bubbles

    ERIC Educational Resources Information Center

    Bader, William A.

    1975-01-01

    Describes the use of a scientific phenomenon related to the concept of surface tension as an intriguing vehicle to direct attention to useful problem solving techniques. The need for a definite building process in attempts to solve mathematical problems is stressed. (EB)

  1. Contextual Problem Solving Model Origination

    ERIC Educational Resources Information Center

    Ernst, Jeremy V.

    2009-01-01

    Problem solving has become a central focus of instructional activity in technology education classrooms at all levels (Boser, 1993). Impact assessment considerations incorporating society, culture, and economics are factors that require high-level deliberation involving critical thinking and the implementation of problem solving strategy. The…

  2. Difficulties in Genetics Problem Solving.

    ERIC Educational Resources Information Center

    Tolman, Richard R.

    1982-01-01

    Examined problem-solving strategies of 30 high school students as they solved genetics problems. Proposes a new sequence of teaching genetics based on results: meiosis, sex chromosomes, sex determination, sex-linked traits, monohybrid and dihybrid crosses (humans), codominance (humans), and Mendel's pea experiments. (JN)

  3. A Method for Solving Problems.

    ERIC Educational Resources Information Center

    Knoop, Robert

    1987-01-01

    Problem solving and decision making are considered to be keys to successful management. A normative method for problem solving is presented, suggesting that the analysis of the problem be structured along a five-step procedure: problem identification, analysis, decision alternatives, decision making, and decision implementation. Follow-up…

  4. Learning Impasses in Problem Solving

    NASA Technical Reports Server (NTRS)

    Hodgson, J. P. E.

    1992-01-01

    Problem Solving systems customarily use backtracking to deal with obstacles that they encounter in the course of trying to solve a problem. This paper outlines an approach in which the possible obstacles are investigated prior to the search for a solution. This provides a solution strategy that avoids backtracking.

  5. Problem Solving, Scaffolding and Learning

    ERIC Educational Resources Information Center

    Lin, Shih-Yin

    2012-01-01

    Helping students to construct robust understanding of physics concepts and develop good solving skills is a central goal in many physics classrooms. This thesis examine students' problem solving abilities from different perspectives and explores strategies to scaffold students' learning. In studies involving analogical problem solving…

  6. Creative Thinking and Problem Solving.

    ERIC Educational Resources Information Center

    Lacy, Grace

    The booklet considers the nature of creativity in children and examines classroom implications. Among the topics addressed are the following: theories about creativity; research; developments in brain research; the creative process; creative problem solving; the Structure of Intellect Problem Solving (SIPS) model; a rationale for creativity in the…

  7. Multiple Ways to Solve Proportions

    ERIC Educational Resources Information Center

    Ercole, Leslie K.; Frantz, Marny; Ashline, George

    2011-01-01

    When solving problems involving proportions, students may intuitively draw on strategies that connect to their understanding of fractions, decimals, and percents. These two statements--"Instruction in solving proportions should include methods that have a strong intuitive basis" and "Teachers should begin instruction with more intuitive…

  8. Problem Solving with General Semantics.

    ERIC Educational Resources Information Center

    Hewson, David

    1996-01-01

    Discusses how to use general semantics formulations to improve problem solving at home or at work--methods come from the areas of artificial intelligence/computer science, engineering, operations research, and psychology. (PA)

  9. Robot, computer problem solving system

    NASA Technical Reports Server (NTRS)

    Becker, J. D.

    1972-01-01

    The development of a computer problem solving system is reported that considers physical problems faced by an artificial robot moving around in a complex environment. Fundamental interaction constraints with a real environment are simulated for the robot by visual scan and creation of an internal environmental model. The programming system used in constructing the problem solving system for the simulated robot and its simulated world environment is outlined together with the task that the system is capable of performing. A very general framework for understanding the relationship between an observed behavior and an adequate description of that behavior is included.

  10. Problem-Solving Test: Pyrosequencing

    ERIC Educational Resources Information Center

    Szeberenyi, Jozsef

    2013-01-01

    Terms to be familiar with before you start to solve the test: Maxam-Gilbert sequencing, Sanger sequencing, gel electrophoresis, DNA synthesis reaction, polymerase chain reaction, template, primer, DNA polymerase, deoxyribonucleoside triphosphates, orthophosphate, pyrophosphate, nucleoside monophosphates, luminescence, acid anhydride bond,…

  11. Robot computer problem solving system

    NASA Technical Reports Server (NTRS)

    Becker, J. D.; Merriam, E. W.

    1974-01-01

    The conceptual, experimental, and practical aspects of the development of a robot computer problem solving system were investigated. The distinctive characteristics were formulated of the approach taken in relation to various studies of cognition and robotics. Vehicle and eye control systems were structured, and the information to be generated by the visual system is defined.

  12. Solving Problems by Reading Mathematics.

    ERIC Educational Resources Information Center

    Witkowski, Joseph C.

    1988-01-01

    A course at the University of Georgia is described that helps students acquire problem-solving skills so that ultimately the entire remedial program would be improved, giving students with major deficiencies in basic skills a better chance to succeed in their regular university courses. (MLW)

  13. Robot computer problem solving system

    NASA Technical Reports Server (NTRS)

    Becker, J. D.; Merriam, E. W.

    1974-01-01

    The conceptual, experimental, and practical phases of developing a robot computer problem solving system are outlined. Robot intelligence, conversion of the programming language SAIL to run under the THNEX monitor, and the use of the network to run several cooperating jobs at different sites are discussed.

  14. Time Out for Problem Solving.

    ERIC Educational Resources Information Center

    Champagne, Audrey B.; And Others

    Teachers in elementary schools, supervisors of instruction, and other educational practitioners are the primary audience for this publication. The paper presents philosophical, psychological, and practical reasons for including a problem-solving approach in elementary school instruction. It draws on the writings of John Dewey, Jean Piaget, James…

  15. Problem Solving through Paper Folding

    ERIC Educational Resources Information Center

    Wares, Arsalan

    2014-01-01

    The purpose of this article is to describe a couple of challenging mathematical problems that involve paper folding. These problem-solving tasks can be used to foster geometric and algebraic thinking among students. The context of paper folding makes some of the abstract mathematical ideas involved relatively concrete. When implemented…

  16. Customer Service & Team Problem Solving.

    ERIC Educational Resources Information Center

    Martin, Sabrina Budasi

    This curriculum guide provides materials for a six-session, site-specific training course in customer service and team problem solving for the Claretian Medical Center. The course outline is followed the six lesson plans. Components of each lesson plan include a list of objectives, an outline of activities and discussion topics for the lesson,…

  17. Quantitative Reasoning in Problem Solving

    ERIC Educational Resources Information Center

    Ramful, Ajay; Ho, Siew Yin

    2015-01-01

    In this article, Ajay Ramful and Siew Yin Ho explain the meaning of quantitative reasoning, describing how it is used in the to solve mathematical problems. They also describe a diagrammatic approach to represent relationships among quantities and provide examples of problems and their solutions.

  18. Supporting Problem Solving in PBL

    ERIC Educational Resources Information Center

    Jonassen, David

    2011-01-01

    Although the characteristics of PBL (problem focused, student centered, self-directed, etc.) are well known, the components of a problem-based learning environment (PBLE) and the cognitive scaffolds necessary to support learning to solve different kinds of problems with different learners is less clear. This paper identifies the different…

  19. Students' Problem Solving and Justification

    ERIC Educational Resources Information Center

    Glass, Barbara; Maher, Carolyn A.

    2004-01-01

    This paper reports on methods of students' justifications of their solution to a problem in the area of combinatorics. From the analysis of the problem solving of 150 students in a variety of settings from high-school to graduate study, four major forms of reasoning evolved: (1) Justification by Cases, (2) Inductive Argument, (3) Elimination…

  20. Genetics problem solving and worldview

    NASA Astrophysics Data System (ADS)

    Dale, Esther

    The research goal was to determine whether worldview relates to traditional and real-world genetics problem solving. Traditionally, scientific literacy emphasized content knowledge alone because it was sufficient to solve traditional problems. The contemporary definition of scientific literacy is, "The knowledge and understanding of scientific concepts and processes required for personal decision-making, participation in civic and cultural affairs and economic productivity" (NRC, 1996). An expanded definition of scientific literacy is needed to solve socioscientific issues (SSI), complex social issues with conceptual, procedural, or technological associations with science. Teaching content knowledge alone assumes that students will find the scientific explanation of a phenomenon to be superior to a non-science explanation. Formal science and everyday ways of thinking about science are two different cultures (Palmer, 1999). Students address this rift with cognitive apartheid, the boxing away of science knowledge from other types of knowledge (Jedege & Aikenhead, 1999). By addressing worldview, cognitive apartheid may decrease and scientific literacy may increase. Introductory biology students at the University of Minnesota during fall semester 2005 completed a written questionnaire-including a genetics content-knowledge test, four genetic dilemmas, the Worldview Assessment Instrument (WAI) and some items about demographics and religiosity. Six students responded to the interview protocol. Based on statistical analysis and interview data, this study concluded the following: (1) Worldview, in the form of metaphysics, relates to solving traditional genetic dilemmas. (2) Worldview, in the form of agency, relates to solving traditional genetics problems. (3) Thus, worldview must be addressed in curriculum, instruction, and assessment.

  1. An NOy* Algorithm for SOLVE

    NASA Technical Reports Server (NTRS)

    Loewenstein, M.; Greenblatt. B. J.; Jost, H.; Podolske, J. R.; Elkins, Jim; Hurst, Dale; Romanashkin, Pavel; Atlas, Elliott; Schauffler, Sue; Donnelly, Steve; Condon, Estelle (Technical Monitor)

    2000-01-01

    De-nitrification and excess re-nitrification was widely observed by ER-2 instruments in the Arctic vortex during SOLVE in winter/spring 2000. Analyses of these events requires a knowledge of the initial or pre-vortex state of the sampled air masses. The canonical relationship of NOy to the long-lived tracer N2O observed in the unperturbed stratosphere is generally used for this purpose. In this paper we will attempt to establish the current unperturbed NOy:N2O relationship (NOy* algorithm) using the ensemble of extra-vortex data from in situ instruments flying on the ER-2 and DC-8, and from the Mark IV remote measurements on the OMS balloon. Initial analysis indicates a change in the SOLVE NOy* from the values predicted by the 1994 Northern Hemisphere NOy* algorithm which was derived from the observations in the ASHOE/MAESA campaign.

  2. Quantum Computing: Solving Complex Problems

    ScienceCinema

    DiVincenzo, David [IBM Watson Research Center

    2009-09-01

    One of the motivating ideas of quantum computation was that there could be a new kind of machine that would solve hard problems in quantum mechanics. There has been significant progress towards the experimental realization of these machines (which I will review), but there are still many questions about how such a machine could solve computational problems of interest in quantum physics. New categorizations of the complexity of computational problems have now been invented to describe quantum simulation. The bad news is that some of these problems are believed to be intractable even on a quantum computer, falling into a quantum analog of the NP class. The good news is that there are many other new classifications of tractability that may apply to several situations of physical interest.

  3. Quantum Computing: Solving Complex Problems

    SciTech Connect

    DiVincenzo, David

    2007-04-12

    One of the motivating ideas of quantum computation was that there could be a new kind of machine that would solve hard problems in quantum mechanics. There has been significant progress towards the experimental realization of these machines (which I will review), but there are still many questions about how such a machine could solve computational problems of interest in quantum physics. New categorizations of the complexity of computational problems have now been invented to describe quantum simulation. The bad news is that some of these problems are believed to be intractable even on a quantum computer, falling into a quantum analog of the NP class. The good news is that there are many other new classifications of tractability that may apply to several situations of physical interest.

  4. Quantum Computing: Solving Complex Problems

    SciTech Connect

    DiVincenzo, David

    2007-04-11

    One of the motivating ideas of quantum computation was that there could be a new kind of machine that would solve hard problems in quantum mechanics. There has been significant progress towards the experimental realization of these machines (which I will review), but there are still many questions about how such a machine could solve computational problems of interest in quantum physics. New categorizations of the complexity of computational problems have now been invented to describe quantum simulation. The bad news is that some of these problems are believed to be intractable even on a quantum computer, falling into a quantum analog of the NP class. The good news is that there are many other new classifications of tractability that may apply to several situations of physical interest.

  5. Maze Solving by Chemotactic Droplets

    SciTech Connect

    Lagzi, Istvan; Soh, Siowling; Wesson, Paul J.; Browne, Kevin P.; Grzybowski, Bartosz A.

    2010-01-11

    Droplets emitting surface-active chemicals exhibit chemotaxis toward low-pH regions. Such droplets are self-propelled and navigate through a complex maze to seek a source of acid placed at one of the maze’s exits. In doing so, the droplets find the shortest path through the maze. Chemotaxis and maze solving are due to an interplay between acid/base chemistry and surface tension effects.

  6. Journey toward Teaching Mathematics through Problem Solving

    ERIC Educational Resources Information Center

    Sakshaug, Lynae E.; Wohlhuter, Kay A.

    2010-01-01

    Teaching mathematics through problem solving is a challenge for teachers who learned mathematics by doing exercises. How do teachers develop their own problem solving abilities as well as their abilities to teach mathematics through problem solving? A group of teachers began the journey of learning to teach through problem solving while taking a…

  7. Problem Solving in the Context of Medicine.

    ERIC Educational Resources Information Center

    Woods, Donald R.

    1997-01-01

    Reviews the book "Medical Problem Solving: An Analysis of Clinical Reasoning," a seminal book whose conclusions on problem solving in medical fields are still valid today. Discusses major problem-solving findings of this book, the application of the findings to education, and relating knowledge to problem-solving skills. (JRH)

  8. Assessing Algebraic Solving Ability: A Theoretical Framework

    ERIC Educational Resources Information Center

    Lian, Lim Hooi; Yew, Wun Thiam

    2012-01-01

    Algebraic solving ability had been discussed by many educators and researchers. There exists no definite definition for algebraic solving ability as it can be viewed from different perspectives. In this paper, the nature of algebraic solving ability in terms of algebraic processes that demonstrate the ability in solving algebraic problem is…

  9. Solving the Dark Matter Problem

    ScienceCinema

    Baltz, Ted

    2009-09-01

    Cosmological observations have firmly established that the majority of matter in the universe is of an unknown type, called 'dark matter'. A compelling hypothesis is that the dark matter consists of weakly interacting massive particles (WIMPs) in the mass range around 100 GeV. If the WIMP hypothesis is correct, such particles could be created and studied at accelerators. Furthermore they could be directly detected as the primary component of our galaxy. Solving the dark matter problem requires that the connection be made between the two. We describe some theoretical and experimental avenues that might lead to this connection.

  10. Solving Equations of Multibody Dynamics

    NASA Technical Reports Server (NTRS)

    Jain, Abhinandan; Lim, Christopher

    2007-01-01

    Darts++ is a computer program for solving the equations of motion of a multibody system or of a multibody model of a dynamic system. It is intended especially for use in dynamical simulations performed in designing and analyzing, and developing software for the control of, complex mechanical systems. Darts++ is based on the Spatial-Operator- Algebra formulation for multibody dynamics. This software reads a description of a multibody system from a model data file, then constructs and implements an efficient algorithm that solves the dynamical equations of the system. The efficiency and, hence, the computational speed is sufficient to make Darts++ suitable for use in realtime closed-loop simulations. Darts++ features an object-oriented software architecture that enables reconfiguration of system topology at run time; in contrast, in related prior software, system topology is fixed during initialization. Darts++ provides an interface to scripting languages, including Tcl and Python, that enable the user to configure and interact with simulation objects at run time.

  11. Modeling Applied to Problem Solving

    NASA Astrophysics Data System (ADS)

    Pawl, Andrew; Barrantes, Analia; Pritchard, David E.

    2009-11-01

    We describe a modeling approach to help students learn expert problem solving. Models are used to present and hierarchically organize the syllabus content and apply it to problem solving, but students do not develop and validate their own Models through guided discovery. Instead, students classify problems under the appropriate instructor-generated Model by selecting a system to consider and describing the interactions that are relevant to that system. We believe that this explicit System, Interactions and Model (S.I.M.) problem modeling strategy represents a key simplification and clarification of the widely disseminated modeling approach originated by Hestenes and collaborators. Our narrower focus allows modeling physics to be integrated into (as opposed to replacing) a typical introductory college mechanics course, while preserving the emphasis on understanding systems and interactions that is the essence of modeling. We have employed the approach in a three-week review course for MIT freshmen who received a D in the fall mechanics course with very encouraging results.

  12. Robot computer problem solving system

    NASA Technical Reports Server (NTRS)

    Merriam, E. W.; Becker, J. D.

    1973-01-01

    A robot computer problem solving system which represents a robot exploration vehicle in a simulated Mars environment is described. The model exhibits changes and improvements made on a previously designed robot in a city environment. The Martian environment is modeled in Cartesian coordinates; objects are scattered about a plane; arbitrary restrictions on the robot's vision have been removed; and the robot's path contains arbitrary curves. New environmental features, particularly the visual occlusion of objects by other objects, were added to the model. Two different algorithms were developed for computing occlusion. Movement and vision capabilities of the robot were established in the Mars environment, using LISP/FORTRAN interface for computational efficiency. The graphical display program was redesigned to reflect the change to the Mars-like environment.

  13. SOLV-DB: Solvents Data

    DOE Data Explorer

    SOLV-DB provides a specialized mix of information on commercially available solvents. The development of the database was funded under the Strategic Environmental Research and Development Program (SERDP) with funds from EPA and DOE's Office of Industrial Technologies in EE. The information includes: • Health and safety considerations involved in choosing and using solvents • Chemical and physical data affecting the suitability of a particular solvent for a wide range of potential applications • Regulatory responsibilities, including exposure and effluent limits, hazard classification status with respect to several key statutes, and selected reporting requirements • Environmental fate data, to indicate whether a solvent is likely to break down or persist in air or water, and what types of waste treatment techniques may apply to it • CAS numbers (from Chemical Abstracts Service) and Sax Numbers (from Sax, et.al., Dangerous Properties of Industrial Materials) Supplier Information See help information at http://solvdb.ncms.org/welcome.htm (Specialized Interface)

  14. Maze-solving by chemotaxis

    NASA Astrophysics Data System (ADS)

    Reynolds, A. M.

    2010-06-01

    Here, we report on numerical simulations showing that chemotaxis will take a body through a maze via the shortest possible route to the source of a chemoattractant. This is a robust finding that does not depend on the geometrical makeup of the maze. The predictions are supported by recent experimental studies which have shown that by moving down gradients in pH , a droplet of organic solvent can find the shortest of multiple possible paths through a maze to an acid-soaked exit. They are also consistent with numerical and experimental evidence that plant-parasitic nematodes take the shortest route through the labyrinth of air-filled pores within soil to preferred host plants that produce volatile chemoattractants. The predictions support the view that maze-solving is a robust property of chemotaxis and is not specific to particular kinds of maze or to the fractal structure of air-filled channels within soils.

  15. Solving the structure of metakaolin

    SciTech Connect

    Proffen, Thomas E; White, Claire E; Provis, John L; Riley, Daniel P; Van Deventer, Jannie S J

    2009-01-01

    Metakaolin has been used extensively as a cement additive and paint extender, and recently as a geopolymer precursor. This disordered layered aluminosilicate is formed via the dehydroxylation of kaolinite. However, an accurate representation of its atomic structure has bever before been presented. Here, a novel synergy between total scattering and density functional modeling is presented to solve the structure of metakaolin. The metastable structure is elucidated by iterating between least-squares real-space refinement using neutron pair distribution function data, and geometry optimization using density functional modeling. The resulting structural representation is both energetically feasible and in excellent agreement with experimental data. This accurate structure of metakaolin provides new insight into the local environment of the aluminum atoms, with evidence of the existence of tri-coordinated aluminum. By the availability of this detailed atomic description, there exists the opportunity to tailor chemical and mechanical processes involving metakaolin at the atomic level to obtain optimal performance at the macro-scale.

  16. Problem Solving in the General Mathematics Classroom

    ERIC Educational Resources Information Center

    Troutman, Andria Price; Lichtenberg, Betty Plunkett

    1974-01-01

    Five steps common to different problem solving models are listed. Next, seven specific abilities related to solving problems are discussed and examples given. Sample activities, appropriate to help in developing these specific abilities, are suggested. (LS)

  17. Using Logo to Develop Problem Solving Skills.

    ERIC Educational Resources Information Center

    Denenberg, Stewart A.

    1993-01-01

    Proposes using computer programing teaching problem solving. Describes the problem-solving technique of Top-Down Design, discusses its application to LOGO, and provides examples of programs using LOGO. (MDH)

  18. Some Applications of Algebraic System Solving

    ERIC Educational Resources Information Center

    Roanes-Lozano, Eugenio

    2011-01-01

    Technology and, in particular, computer algebra systems, allows us to change both the way we teach mathematics and the mathematical curriculum. Curiously enough, unlike what happens with linear system solving, algebraic system solving is not widely known. The aim of this paper is to show that, although the theory lying behind the "exact solve"…

  19. Research on Computers and Problem Solving.

    ERIC Educational Resources Information Center

    Burton, John K.; And Others

    1988-01-01

    Eight articles review and report on research involving computers and problem solving skills. Topics discussed include research design; problem solving skills and programing languages, including BASIC and LOGO; computer anxiety; diagnostic programs for arithmetic problems; and relationships between ability and problem solving scores and between…

  20. Theoretical and Philosophical Perspectives to Problem Solving.

    ERIC Educational Resources Information Center

    Sherman, Thomas M.; And Others

    1988-01-01

    Five articles explore various theoretical aspects of problems and problem solving skills. Highlights include strategies to learn problem solving skills; knowledge structures; metacognition; behavioral processes and cognitive psychology; erotetic logic; creativity as an aspect of computer problem solving; and programing as a problem-solving…

  1. Perspectives on Problem Solving and Instruction

    ERIC Educational Resources Information Center

    van Merrienboer, Jeroen J. G.

    2013-01-01

    Most educators claim that problem solving is important, but they take very different perspective on it and there is little agreement on how it should be taught. This article aims to sort out the different perspectives and discusses problem solving as a goal, a method, and a skill. As a goal, problem solving should not be limited to well-structured…

  2. Developing Creativity through Collaborative Problem Solving

    ERIC Educational Resources Information Center

    Albert, Lillie R.; Kim, Rina

    2013-01-01

    This paper discusses an alternative approach for developing problem solving experiences for students. The major argument is that students can develop their creativity by engaging in collaborative problem solving activities in which they apply a variety of mathematical methods creatively to solve problems. The argument is supported by: considering…

  3. King Oedipus and the Problem Solving Process.

    ERIC Educational Resources Information Center

    Borchardt, Donald A.

    An analysis of the problem solving process reveals at least three options: (1) finding the cause, (2) solving the problem, and (3) anticipating potential problems. These methods may be illustrated by examining "Oedipus Tyrannus," a play in which a king attempts to deal with a problem that appears to be beyond his ability to solve, and applying…

  4. Disciplinary Foundations for Solving Interdisciplinary Scientific Problems

    ERIC Educational Resources Information Center

    Zhang, Dongmei; Shen, Ji

    2015-01-01

    Problem-solving has been one of the major strands in science education research. But much of the problem-solving research has been conducted on discipline-based contexts; little research has been done on how students, especially individuals, solve interdisciplinary problems. To understand how individuals reason about interdisciplinary problems, we…

  5. Kindergarten Students Solving Mathematical Word Problems

    ERIC Educational Resources Information Center

    Johnson, Nickey Owen

    2013-01-01

    The purpose of this study was to explore problem solving with kindergarten students. This line of inquiry is highly significant given that Common Core State Standards emphasize deep, conceptual understanding in mathematics as well as problem solving in kindergarten. However, there is little research on problem solving with kindergarten students.…

  6. Collis-Romberg Mathematical Problem Solving Profiles.

    ERIC Educational Resources Information Center

    Collis, K. F.; Romberg, T. A.

    Problem solving has become a focus of mathematics programs in Australia in recent years, necessitating the assessment of students' problem-solving abilities. This manual provides a problem-solving assessment and teaching resource package containing four elements: (1) profiles assessment items; (2) profiles diagnostic forms for recording individual…

  7. Affect and Problem Solving: Two Theoretical Perspectives.

    ERIC Educational Resources Information Center

    McLeod, Douglas B.

    Cognitive factors related to problem solving have been explored, but affective factors also play an important role in the teaching of mathematical problem solving. This paper outlines the theories of George Mandler and Bernard Weiner, providing a useful background for research related to affect and problem solving. Data related to the two theories…

  8. LEGO Robotics: An Authentic Problem Solving Tool?

    ERIC Educational Resources Information Center

    Castledine, Alanah-Rei; Chalmers, Chris

    2011-01-01

    With the current curriculum focus on correlating classroom problem solving lessons to real-world contexts, are LEGO robotics an effective problem solving tool? This present study was designed to investigate this question and to ascertain what problem solving strategies primary students engaged with when working with LEGO robotics and whether the…

  9. Community-powered problem solving.

    PubMed

    Gouillart, Francis; Billings, Douglas

    2013-04-01

    Traditionally, companies have managed their constituencies with specific processes: marketing to customers, procuring from vendors, developing HR policies for employees, and so on. The problem is, such processes focus on repeatability and compliance, so they can lead to stagnation. Inviting your constituencies to collectively help you solve problems and exploit opportunities--"co-creation"--is a better approach. It allows you to continually tap the skills and insights of huge numbers of stakeholders and develop new ways to produce value for all. The idea is to provide stakeholders with platforms (physical and digital forums) on which they can interact, get them to start exploring new experiences and connections, and let the system grow organically. A co-creation initiative by a unit of Becton, Dickinson and Company demonstrates how this works. A global leader in syringes, BD set out to deepen its ties with hospital customers and help them reduce the incidence of infections from unsafe injection and syringe disposal practices. The effort began with a cross-functional internal team, brought in the hospital procurement and supply managers BD had relationships with, and then reached out to hospitals' infection-prevention and occupational health leaders. Eventually product designers, nurses, sustainability staffers, and even hospital CFOs were using the platform, contributing data that generated new best practices and reduced infections. PMID:23593769

  10. Distance Measurement Solves Astrophysical Mysteries

    NASA Astrophysics Data System (ADS)

    2003-08-01

    Location, location, and location. The old real-estate adage about what's really important proved applicable to astrophysics as astronomers used the sharp radio "vision" of the National Science Foundation's Very Long Baseline Array (VLBA) to pinpoint the distance to a pulsar. Their accurate distance measurement then resolved a dispute over the pulsar's birthplace, allowed the astronomers to determine the size of its neutron star and possibly solve a mystery about cosmic rays. "Getting an accurate distance to this pulsar gave us a real bonanza," said Walter Brisken, of the National Radio Astronomy Observatory (NRAO) in Socorro, NM. Monogem Ring The Monogem Ring, in X-Ray Image by ROSAT satellite CREDIT: Max-Planck Institute, American Astronomical Society (Click on Image for Larger Version) The pulsar, called PSR B0656+14, is in the constellation Gemini, and appears to be near the center of a circular supernova remnant that straddles Gemini and its neighboring constellation, Monoceros, and is thus called the Monogem Ring. Since pulsars are superdense, spinning neutron stars left over when a massive star explodes as a supernova, it was logical to assume that the Monogem Ring, the shell of debris from a supernova explosion, was the remnant of the blast that created the pulsar. However, astronomers using indirect methods of determining the distance to the pulsar had concluded that it was nearly 2500 light-years from Earth. On the other hand, the supernova remnant was determined to be only about 1000 light-years from Earth. It seemed unlikely that the two were related, but instead appeared nearby in the sky purely by a chance juxtaposition. Brisken and his colleagues used the VLBA to make precise measurements of the sky position of PSR B0656+14 from 2000 to 2002. They were able to detect the slight offset in the object's apparent position when viewed from opposite sides of Earth's orbit around the Sun. This effect, called parallax, provides a direct measurement of

  11. Analog Processor To Solve Optimization Problems

    NASA Technical Reports Server (NTRS)

    Duong, Tuan A.; Eberhardt, Silvio P.; Thakoor, Anil P.

    1993-01-01

    Proposed analog processor solves "traveling-salesman" problem, considered paradigm of global-optimization problems involving routing or allocation of resources. Includes electronic neural network and auxiliary circuitry based partly on concepts described in "Neural-Network Processor Would Allocate Resources" (NPO-17781) and "Neural Network Solves 'Traveling-Salesman' Problem" (NPO-17807). Processor based on highly parallel computing solves problem in significantly less time.

  12. Solving global optimization problems on GPU cluster

    NASA Astrophysics Data System (ADS)

    Barkalov, Konstantin; Gergel, Victor; Lebedev, Ilya

    2016-06-01

    The paper contains the results of investigation of a parallel global optimization algorithm combined with a dimension reduction scheme. This allows solving multidimensional problems by means of reducing to data-independent subproblems with smaller dimension solved in parallel. The new element implemented in the research consists in using several graphic accelerators at different computing nodes. The paper also includes results of solving problems of well-known multiextremal test class GKLS on Lobachevsky supercomputer using tens of thousands of GPU cores.

  13. Fibonacci's Triangle: A Vehicle for Problem Solving.

    ERIC Educational Resources Information Center

    Ouellette, Hugh

    1979-01-01

    A method for solving certain types of problems is illustrated by problems related to Fibonacci's triangle. The method involves pattern recognition, generalizing, algebraic manipulation, and mathematical induction. (MP)

  14. Mobile serious games for collaborative problem solving.

    PubMed

    Sanchez, Jaime; Mendoza, Claudia; Salinas, Alvaro

    2009-01-01

    This paper presents the results obtained from the implementation of a series of learning activities based on mobile serious games (MSG) for the development of problem-solving and collaborative skills in Chilean 8th grade students. Three MSGs were developed and played by teams of four students, who had to solve the problems posed by the game collaboratively. The data shows that the experimental group had a higher perception of their own skills of collaboration and of the plan execution dimension of problem solving than the control group, providing empirical evidence regarding the contribution of MSGs to the development of collaborative problem-solving skills. PMID:19592762

  15. Taking "From Scratch" out of Problem Solving

    ERIC Educational Resources Information Center

    Brown, Wayne

    2007-01-01

    Solving problems and creating processes and procedures from the ground up has long been part of the IT department's way of operating. IT staffs will continue to encounter new problems to solve and new technologies to be implemented. They also must involve their constituents in the creation of solutions. Nonetheless, for many issues they no longer…

  16. A Problem-Solving Model for Instruction.

    ERIC Educational Resources Information Center

    Scott, Roger O.

    This second in a series of three papers on the Associated Staff Training Program of the Foreign Language Innovative Curriculum Study concentrates on the problem solving strategy employed by the program's specially trained innovative agents--the Instructional Systems Consultants (ISC). The problem-solving method used is first illustrated by citing…

  17. Error Detection Processes in Problem Solving.

    ERIC Educational Resources Information Center

    Allwood, Carl Martin

    1984-01-01

    Describes a study which analyzed problem solvers' error detection processes by instructing subjects to think aloud when solving statistical problems. Effects of evaluative episodes on error detection, detection of different error types, error detection processes per se, and relationship of error detection behavior to problem-solving proficiency…

  18. Conceptual Problem Solving in High School Physics

    ERIC Educational Resources Information Center

    Docktor, Jennifer L.; Strand, Natalie E.; Mestre, José P.; Ross, Brian H.

    2015-01-01

    Problem solving is a critical element of learning physics. However, traditional instruction often emphasizes the quantitative aspects of problem solving such as equations and mathematical procedures rather than qualitative analysis for selecting appropriate concepts and principles. This study describes the development and evaluation of an…

  19. Solving Problems in Genetics II: Conceptual Restructuring

    ERIC Educational Resources Information Center

    Orcajo, Teresa Ibanez; Aznar, Mercedes Martinez

    2005-01-01

    This paper presents the results of part of an investigation carried out with fourth-level Spanish secondary education students (15 years old), in which we implemented a teaching unit based on problem-solving methodology as an investigation to teach genetics and human inheritance curricular contents. By solving open problems, the students…

  20. Teaching Top-Down Problem Solving.

    ERIC Educational Resources Information Center

    Patrick, Charles

    Top-down problem solving is a methodical approach to obtaining real solutions for open-ended problems common in the realms of engineering and science. The technique provides a means for logically understanding a problem prior to attempting a solution. Steps in the top-down problem-solving method include the following: (1) identifying a need; (2)…

  1. Problem Solving Software for Math Classes.

    ERIC Educational Resources Information Center

    Troutner, Joanne

    1987-01-01

    Described are 10 computer software programs for problem solving related to mathematics. Programs described are: (1) Box Solves Story Problems; (2) Safari Search; (3) Puzzle Tanks; (4) The King's Rule; (5) The Factory; (6) The Royal Rules; (7) The Enchanted Forest; (8) Gears; (9) The Super Factory; and (10) Creativity Unlimited. (RH)

  2. Solving Problems with Charts & Tables. Pipefitter.

    ERIC Educational Resources Information Center

    Greater Baton Rouge Chamber of Commerce, LA.

    Developed as part of the ABCs of Construction National Workplace Literacy Project, this instructional module is designed to help individuals employed as pipefitters learn to solve problems with charts and tables. Outlined in the first section is a five-step procedure for solving problems involving tables and/or charts: identifying the question to…

  3. Student Modeling Based on Problem Solving Times

    ERIC Educational Resources Information Center

    Pelánek, Radek; Jarušek, Petr

    2015-01-01

    Student modeling in intelligent tutoring systems is mostly concerned with modeling correctness of students' answers. As interactive problem solving activities become increasingly common in educational systems, it is useful to focus also on timing information associated with problem solving. We argue that the focus on timing is natural for certain…

  4. Metacognition: Student Reflections on Problem Solving

    ERIC Educational Resources Information Center

    Wismath, Shelly; Orr, Doug; Good, Brandon

    2014-01-01

    Twenty-first century teaching and learning focus on the fundamental skills of critical thinking and problem solving, creativity and innovation, and collaboration and communication. Metacognition is a crucial aspect of both problem solving and critical thinking, but it is often difficult to get students to engage in authentic metacognitive…

  5. Distributed problem solving by pilots and dispatchers

    NASA Technical Reports Server (NTRS)

    Orasanu, Judith; Wich, Mike; Fischer, Ute; Jobe, Kim; Mccoy, Elaine; Beatty, Roger; Smith, Phil

    1993-01-01

    The study addressed the following question: Are flight planning problems solved differently by PILOTS and DISPATCHERS when they work alone versus when they work together? Aspect of their performance that were of interest include the following: Problem perception and definition; Problem solving strategies and information use; Options considered; Solution and rational; and errors.

  6. Mathematical Problem Solving through Sequential Process Analysis

    ERIC Educational Resources Information Center

    Codina, A.; Cañadas, M. C.; Castro, E.

    2015-01-01

    Introduction: The macroscopic perspective is one of the frameworks for research on problem solving in mathematics education. Coming from this perspective, our study addresses the stages of thought in mathematical problem solving, offering an innovative approach because we apply sequential relations and global interrelations between the different…

  7. General Description of Human Problem Solving.

    ERIC Educational Resources Information Center

    Klein, Gary A.; Weitzenfeld, Julian

    A theoretical model relating problem identification to problem solving is presented. The main purpose of the study is to increase understanding of decision making among Air Force educators. The problem-solving process is defined as the generation and evaluation of alternatives that will accomplish what is needed and the reidentification of what is…

  8. Problem Solving and Technology. ACESIA Monograph 2.

    ERIC Educational Resources Information Center

    Lomon, Earle L.; And Others

    1977-01-01

    The two articles dealing with problem solving and technology in this publication should be useful to those developing the kinds of materials, experiences, and thinking that elementary school industrial arts offers children. The first article accepts problem solving as an educational goal and reports a timely and universally acceptable approach.…

  9. Geographic Information Systems: Implications for Problem Solving.

    ERIC Educational Resources Information Center

    Audet, Richard H.; Abegg, Gerald L.

    1996-01-01

    Compares expert-/novice-based problem-solving behaviors with a Geographic Information Systems program. Uses naturalistic methods to analyze problem-solving strategies for occurrence of thematic elements. Reports that experts relied on logical formulations to query the database while novices used trial-and-error methods and midlevel cognitive…

  10. Children Solving Problems. The Developing Child Series.

    ERIC Educational Resources Information Center

    Thornton, Stephanie

    The developmental increase in the ability to solve problems is a puzzle. Does it come from basic changes in mental skills, or is it a matter of practice? This book from the Developing Child series synthesizes recent research examining children's problem-solving skills development. Chapter 1 presents the major themes: (1) there is increasing…

  11. Dynamic Problem Solving: A New Assessment Perspective

    ERIC Educational Resources Information Center

    Greiff, Samuel; Wustenberg, Sascha; Funke, Joachim

    2012-01-01

    This article addresses two unsolved measurement issues in dynamic problem solving (DPS) research: (a) unsystematic construction of DPS tests making a comparison of results obtained in different studies difficult and (b) use of time-intensive single tasks leading to severe reliability problems. To solve these issues, the MicroDYN approach is…

  12. Could HPS Improve Problem-Solving?

    ERIC Educational Resources Information Center

    Coelho, Ricardo Lopes

    2013-01-01

    It is generally accepted nowadays that History and Philosophy of Science (HPS) is useful in understanding scientific concepts, theories and even some experiments. Problem-solving strategies are a significant topic, since students' careers depend on their skill to solve problems. These are the reasons for addressing the question of whether problem…

  13. Problem Solving Interactions on Electronic Networks.

    ERIC Educational Resources Information Center

    Waugh, Michael; And Others

    Arguing that electronic networking provides a medium which is qualitatively superior to the traditional classroom for conducting certain types of problem solving exercises, this paper details the Water Problem Solving Project, which was conducted on the InterCultural Learning Network in 1985 and 1986 with students from the United States, Mexico,…

  14. Teaching and Learning through Problem Solving

    ERIC Educational Resources Information Center

    Ollerton, Mike

    2007-01-01

    In this article, the author relates some problem solving work with primary schools to Department for Children, Schools, and Families (DfES) support. In four primary schools in the West Midlands, the focus was teaching mathematics through problem solving, based on materials published on the DfES "standards" website. The author noticed the way…

  15. Super 7: Daily Exercises in Problem Solving.

    ERIC Educational Resources Information Center

    Hamilton, Octavia

    This book is a year-long program of daily exercises in problem solving for 2nd and 3rd grade students that presents 144 lessons, each with seven problems. The problems cover number sense, computation, measurements, geometry, problem solving, and patterns. The material is presented in a sequential fashion with concepts repeated and expanded, and…

  16. Measuring Problem Solving Skills in "Portal 2"

    ERIC Educational Resources Information Center

    Shute, Valerie J.; Wang, Lubin

    2013-01-01

    This paper examines possible improvement to problem solving skills as a function of playing the video game "Portal 2." Stealth assessment is used in the game to evaluate students' problem solving abilities--specifically basic and flexible rule application. The stealth assessment measures will be validated against commonly accepted…

  17. A Multivariate Model of Physics Problem Solving

    ERIC Educational Resources Information Center

    Taasoobshirazi, Gita; Farley, John

    2013-01-01

    A model of expertise in physics problem solving was tested on undergraduate science, physics, and engineering majors enrolled in an introductory-level physics course. Structural equation modeling was used to test hypothesized relationships among variables linked to expertise in physics problem solving including motivation, metacognitive planning,…

  18. Applications of Symmetry to Problem Solving.

    ERIC Educational Resources Information Center

    Leikin, Roza; Berman, Abraham; Zaslavsky, Orit

    2000-01-01

    Symmetry is an important mathematical concept that plays an extremely important role as a problem solving technique. Presents examples of problems from several branches of mathematics that can be solved using different types of symmetry. Discusses teachers' attitudes and beliefs regarding the use of symmetry in the solutions of these problems.…

  19. Problem Solving Software: What Does It Teach?

    ERIC Educational Resources Information Center

    Duffield, Judith A.

    The purpose of this study was to examine the potential of computer-assisted instruction (CAI) for teaching problem solving skills. It was conducted in three phases. During the first phase, two pieces of problem solving software, "The King's Rule" and "Safari Search," were identified and analyzed. During the second phase, two groups of six…

  20. Developing Legal Problem-Solving Skills.

    ERIC Educational Resources Information Center

    Nathanson, Stephen

    1994-01-01

    A law professor explains how he came to view legal problem solving as the driving concept in law school curriculum design and draws on personal experience and a survey of students concerning teaching methods in a commercial law course. He outlines six curriculum design principles for teaching legal problem solving. (MSE)

  1. Solving Cubic Equations by Polynomial Decomposition

    ERIC Educational Resources Information Center

    Kulkarni, Raghavendra G.

    2011-01-01

    Several mathematicians struggled to solve cubic equations, and in 1515 Scipione del Ferro reportedly solved the cubic while participating in a local mathematical contest, but did not bother to publish his method. Then it was Cardano (1539) who first published the solution to the general cubic equation in his book "The Great Art, or, The Rules of…

  2. Problem solving in health services organizations.

    PubMed

    Rakich, J S; Krigline, A B

    1996-01-01

    Health services organization managers at all levels are constantly confronted with problems. Conditions encountered that initiate the need for problem solving are opportunity, threat, crisis, deviation, and improvement. A general problem-solving model presenting an orderly process by which managers can approach this important task is described. An example of the model applied to the current strategic climate is presented. PMID:10158720

  3. Beyond Computation: Improving Mathematical Problem Solving.

    ERIC Educational Resources Information Center

    Anderson, Jennifer M.; Olson, Jennifer S.; Wrobel, Margaret L.

    This action research describes a program for improving mathematical problem solving skills. The targeted population consisted of first grade students in a transient, middle class community as well as third and sixth grade students from a growing, middle to upper class in Illinois. The concerns of problem solving were documented through teacher…

  4. Parallel Algorithm Solves Coupled Differential Equations

    NASA Technical Reports Server (NTRS)

    Hayashi, A.

    1987-01-01

    Numerical methods adapted to concurrent processing. Algorithm solves set of coupled partial differential equations by numerical integration. Adapted to run on hypercube computer, algorithm separates problem into smaller problems solved concurrently. Increase in computing speed with concurrent processing over that achievable with conventional sequential processing appreciable, especially for large problems.

  5. Enigma of Runaway Stars Solved

    NASA Astrophysics Data System (ADS)

    1997-01-01

    Supernova Propels Companion Star through Interstellar Space The following success story is a classical illustration of scientific progress through concerted interplay of observation and theory. It concerns a 35-year old mystery which has now been solved by means of exciting observations of a strange double star. An added touch is the successive involvement of astronomers connected to the European Southern Observatory. For many years, astronomers have been puzzled by the fact that, among the thousands of very young, hot and heavy stars which have been observed in the Milky Way, there are some that move with exceptionally high velocities. In some cases, motions well above 100 km/sec, or ten times more than normal for such stars, have been measured. How is this possible? Which mechanism is responsible for the large amounts of energy needed to move such heavy bodies at such high speeds? Could it be that these stars are accelerated during the powerful explosion of a companion star as a supernova? Such a scenario was proposed in 1961 by Adriaan Blaauw [1], but until now, observational proof has been lacking. Now, however, strong supporting evidence for this mechanism has become available from observations obtained at the ESO La Silla observatory. The mysterious runaway stars OB-runaway stars [2] are heavy stars that travel through interstellar space with an anomalously high velocity. They have been known for several decades, but it has always been a problem to explain their high velocities. Although most OB-runaway stars are located at distances of several thousands of lightyears, their high velocity results in a measurable change in position on sky photos taken several years apart. The velocity component in the direction of the Earth can be measured very accurately from a spectrogram. From a combination of such observations, it is possible to measure the space velocity of OB-runaways. Bow shocks reveal runaway stars It has also been found that some OB-runaways display

  6. [Antiviral properties of basidiomycetes metabolites].

    PubMed

    Avtonomova, A V; Krasnopolskaya, L M

    2014-01-01

    The data on the antiviral action of the Ganoderma lucidum, Lentinus edodes, Grifola frondosa, Agaricus brasiliensis and other basidiomycetes metabolites are summurized. The metabolites of these species of basidiomycetes exhibit a direct antiviral effect on herpes simplex virus types I and II, human immunodeficiency virus (HIV), hepatitis B virus, vesicular stomatitis virus, influenza virus, Epstein-Barr virus, and others. Moreover, metabolites of basidiomycetes increased antiviral immunity. PMID:25975107

  7. WickSolve Version 1.0

    Energy Science and Technology Software Center (ESTSC)

    2011-09-27

    WickSolve is a code used to design wick structures for sodium heat pipe receivers for dish Stirling systems. WickSolve can model distributed pore size wicks in domes and cylinders, and interfaces with CIRCE2, another Sandia code, to determine flux boundary conditions to the wick. WickSolve is available as an executable for Windows computer systems. Wicksolve is used for design of wick structures for high temperature sodium heat pipes for solar applications. These wick structures maymore » contain a distribution of pore sizes (felt metal, sintered metal powders, etc) to enhance heat transfer by allowing partial wick dryout. WickSolve incorporates a 2-D liquid flow model (finite differencing) to model in-plane liquid flow, and a 1-D vapor flow finite difference model for vapor flow perpendicular to the liquid flow surface. The models are coupled by the liquid void fraction in the wick, and solved iteratively.« less

  8. WickSolve Version 1.0

    SciTech Connect

    Andraka, Charles E.

    2011-09-27

    WickSolve is a code used to design wick structures for sodium heat pipe receivers for dish Stirling systems. WickSolve can model distributed pore size wicks in domes and cylinders, and interfaces with CIRCE2, another Sandia code, to determine flux boundary conditions to the wick. WickSolve is available as an executable for Windows computer systems. Wicksolve is used for design of wick structures for high temperature sodium heat pipes for solar applications. These wick structures may contain a distribution of pore sizes (felt metal, sintered metal powders, etc) to enhance heat transfer by allowing partial wick dryout. WickSolve incorporates a 2-D liquid flow model (finite differencing) to model in-plane liquid flow, and a 1-D vapor flow finite difference model for vapor flow perpendicular to the liquid flow surface. The models are coupled by the liquid void fraction in the wick, and solved iteratively.

  9. The Cyclic Nature of Problem Solving: An Emergent Multidimensional Problem-Solving Framework

    ERIC Educational Resources Information Center

    Carlson, Marilyn P.; Bloom, Irene

    2005-01-01

    This paper describes the problem-solving behaviors of 12 mathematicians as they completed four mathematical tasks. The emergent problem-solving framework draws on the large body of research, as grounded by and modified in response to our close observations of these mathematicians. The resulting "Multidimensional Problem-Solving Framework" has four…

  10. Pre-Service Class Teacher' Ability in Solving Mathematical Problems and Skills in Solving Daily Problems

    ERIC Educational Resources Information Center

    Aljaberi, Nahil M.; Gheith, Eman

    2016-01-01

    This study aims to investigate the ability of pre-service class teacher at University of Petrain solving mathematical problems using Polya's Techniques, their level of problem solving skills in daily-life issues. The study also investigates the correlation between their ability to solve mathematical problems and their level of problem solving…

  11. Lesion mapping of social problem solving

    PubMed Central

    Colom, Roberto; Paul, Erick J.; Chau, Aileen; Solomon, Jeffrey; Grafman, Jordan H.

    2014-01-01

    Accumulating neuroscience evidence indicates that human intelligence is supported by a distributed network of frontal and parietal regions that enable complex, goal-directed behaviour. However, the contributions of this network to social aspects of intellectual function remain to be well characterized. Here, we report a human lesion study (n = 144) that investigates the neural bases of social problem solving (measured by the Everyday Problem Solving Inventory) and examine the degree to which individual differences in performance are predicted by a broad spectrum of psychological variables, including psychometric intelligence (measured by the Wechsler Adult Intelligence Scale), emotional intelligence (measured by the Mayer, Salovey, Caruso Emotional Intelligence Test), and personality traits (measured by the Neuroticism-Extraversion-Openness Personality Inventory). Scores for each variable were obtained, followed by voxel-based lesion–symptom mapping. Stepwise regression analyses revealed that working memory, processing speed, and emotional intelligence predict individual differences in everyday problem solving. A targeted analysis of specific everyday problem solving domains (involving friends, home management, consumerism, work, information management, and family) revealed psychological variables that selectively contribute to each. Lesion mapping results indicated that social problem solving, psychometric intelligence, and emotional intelligence are supported by a shared network of frontal, temporal, and parietal regions, including white matter association tracts that bind these areas into a coordinated system. The results support an integrative framework for understanding social intelligence and make specific recommendations for the application of the Everyday Problem Solving Inventory to the study of social problem solving in health and disease. PMID:25070511

  12. Disciplinary Foundations for Solving Interdisciplinary Scientific Problems

    NASA Astrophysics Data System (ADS)

    Zhang, Dongmei; Shen, Ji

    2015-10-01

    Problem-solving has been one of the major strands in science education research. But much of the problem-solving research has been conducted on discipline-based contexts; little research has been done on how students, especially individuals, solve interdisciplinary problems. To understand how individuals reason about interdisciplinary problems, we conducted an interview study with 16 graduate students coming from a variety of disciplinary backgrounds. During the interviews, we asked participants to solve two interdisciplinary science problems on the topic of osmosis. We investigated participants' problem reasoning processes and probed in their attitudes toward general interdisciplinary approach and specific interdisciplinary problems. Through a careful inductive content analysis of their responses, we studied how disciplinary, cognitive, and affective factors influenced their interdisciplinary problems-solving. We found that participants' prior discipline-based science learning experiences had both positive and negative influences on their interdisciplinary problem-solving. These influences were embodied in their conceptualization of the interdisciplinary problems, the strategies they used to integrate different disciplinary knowledge, and the attitudes they had toward interdisciplinary approach in general and specific interdisciplinary problems. This study sheds light on interdisciplinary science education by revealing the complex relationship between disciplinary learning and interdisciplinary problem-solving.

  13. Lesion mapping of social problem solving.

    PubMed

    Barbey, Aron K; Colom, Roberto; Paul, Erick J; Chau, Aileen; Solomon, Jeffrey; Grafman, Jordan H

    2014-10-01

    Accumulating neuroscience evidence indicates that human intelligence is supported by a distributed network of frontal and parietal regions that enable complex, goal-directed behaviour. However, the contributions of this network to social aspects of intellectual function remain to be well characterized. Here, we report a human lesion study (n = 144) that investigates the neural bases of social problem solving (measured by the Everyday Problem Solving Inventory) and examine the degree to which individual differences in performance are predicted by a broad spectrum of psychological variables, including psychometric intelligence (measured by the Wechsler Adult Intelligence Scale), emotional intelligence (measured by the Mayer, Salovey, Caruso Emotional Intelligence Test), and personality traits (measured by the Neuroticism-Extraversion-Openness Personality Inventory). Scores for each variable were obtained, followed by voxel-based lesion-symptom mapping. Stepwise regression analyses revealed that working memory, processing speed, and emotional intelligence predict individual differences in everyday problem solving. A targeted analysis of specific everyday problem solving domains (involving friends, home management, consumerism, work, information management, and family) revealed psychological variables that selectively contribute to each. Lesion mapping results indicated that social problem solving, psychometric intelligence, and emotional intelligence are supported by a shared network of frontal, temporal, and parietal regions, including white matter association tracts that bind these areas into a coordinated system. The results support an integrative framework for understanding social intelligence and make specific recommendations for the application of the Everyday Problem Solving Inventory to the study of social problem solving in health and disease. PMID:25070511

  14. Assertiveness and problem solving in midwives

    PubMed Central

    Yurtsal, Zeliha Burcu; Özdemir, Levent

    2015-01-01

    Background: Midwifery profession is required to bring solutions to problems and a midwife is expected to be an assertive person and to develop midwifery care. This study was planned to examine the relationship between assertiveness and problem-solving skills of midwives. Materials and Methods: This cross-sectional study was conducted with 201 midwives between July 2008 and February 2009 in the city center of Sivas. The Rathus Assertiveness Schedule (RAS) and Problem Solving Inventory (PSI) were used to determine the level of assertiveness and problem-solving skills of midwives. Statistical methods were used as mean, standard deviation, percentage, Student's T, ANOVA and Tukey HSD, Kruskal Wallis, Fisher Exact, Pearson Correlation and Chi-square tests and P < 0.05. Results: The RAS mean scores and the PSI mean scores showed statistically significant differences in terms of a midwife's considering herself as a member of the health team, expressing herself within the health care team, being able to say “no” when necessary, cooperating with her colleagues, taking part in problem-solving skills training. A statistically significant negative correlation was found between the RAS and PSI scores. The RAS scores decreased while the problem-solving scores increased (r: -0451, P < 0.01). Conclusions: There were significant statistical differences between assertiveness levels and problem solving skills of midwives, and midwives who were assertive solved their problems better than did others. Assertiveness and problem-solving skills training will contribute to the success of the midwifery profession. Midwives able to solve problems, and display assertive behaviors will contribute to the development of midwifery profession. PMID:26793247

  15. Solving the Schroedinger equation using Smolyak interpolants

    SciTech Connect

    Avila, Gustavo; Carrington, Tucker Jr.

    2013-10-07

    In this paper, we present a new collocation method for solving the Schroedinger equation. Collocation has the advantage that it obviates integrals. All previous collocation methods have, however, the crucial disadvantage that they require solving a generalized eigenvalue problem. By combining Lagrange-like functions with a Smolyak interpolant, we device a collocation method that does not require solving a generalized eigenvalue problem. We exploit the structure of the grid to develop an efficient algorithm for evaluating the matrix-vector products required to compute energy levels and wavefunctions. Energies systematically converge as the number of points and basis functions are increased.

  16. Spatial visualization in physics problem solving.

    PubMed

    Kozhevnikov, Maria; Motes, Michael A; Hegarty, Mary

    2007-07-01

    Three studies were conducted to examine the relation of spatial visualization to solving kinematics problems that involved either predicting the two-dimensional motion of an object, translating from one frame of reference to another, or interpreting kinematics graphs. In Study 1, 60 physics-naíve students were administered kinematics problems and spatial visualization ability tests. In Study 2, 17 (8 high- and 9 low-spatial ability) additional students completed think-aloud protocols while they solved the kinematics problems. In Study 3, the eye movements of fifteen (9 high- and 6 low-spatial ability) students were recorded while the students solved kinematics problems. In contrast to high-spatial students, most low-spatial students did not combine two motion vectors, were unable to switch frames of reference, and tended to interpret graphs literally. The results of the study suggest an important relationship between spatial visualization ability and solving kinematics problems with multiple spatial parameters. PMID:21635308

  17. Organizational Structure and Complex Problem Solving

    ERIC Educational Resources Information Center

    Becker, Selwyn W.; Baloff, Nicholas

    1969-01-01

    The problem-solving efficiency of different organization structures is discussed in relation to task requirements and the appropriate organizational behavior, to group adaptation to a task over time, and to various group characteristics. (LN)

  18. Physics: Quantum problems solved through games

    NASA Astrophysics Data System (ADS)

    Maniscalco, Sabrina

    2016-04-01

    Humans are better than computers at performing certain tasks because of their intuition and superior visual processing. Video games are now being used to channel these abilities to solve problems in quantum physics. See Letter p.210

  19. Problem Solving, Patterns, Probability, Pascal, and Palindromes.

    ERIC Educational Resources Information Center

    Hylton-Lindsay, Althea Antoinette

    2003-01-01

    Presents a problem-solving activity, the birth order problem, and several solution-seeking strategies. Includes responses of current and prospective teachers and a comparison of various strategies. (YDS)

  20. Problem-solving test: Tryptophan operon mutants.

    PubMed

    Szeberényi, József

    2010-09-01

    Terms to be familiar with before you start to solve the test: tryptophan, operon, operator, repressor, inducer, corepressor, promoter, RNA polymerase, chromosome-polysome complex, regulatory gene, cis-acting element, trans-acting element, plasmid, transformation. PMID:21567855

  1. Using Problem Solving to Teach the Disabled.

    ERIC Educational Resources Information Center

    Cardon, Phillip L.; Scott, Michael L.

    2000-01-01

    Technology education can and should play a role in the development of ideas through problem solving to assist teachers of students with disabilities. Technology teachers can adapt the Engineering for Success model in working with these students. (JOW)

  2. Neural Network Solves "Traveling-Salesman" Problem

    NASA Technical Reports Server (NTRS)

    Thakoor, Anilkumar P.; Moopenn, Alexander W.

    1990-01-01

    Experimental electronic neural network solves "traveling-salesman" problem. Plans round trip of minimum distance among N cities, visiting every city once and only once (without backtracking). This problem is paradigm of many problems of global optimization (e.g., routing or allocation of resources) occuring in industry, business, and government. Applied to large number of cities (or resources), circuits of this kind expected to solve problem faster and more cheaply.

  3. Could HPS Improve Problem-Solving?

    NASA Astrophysics Data System (ADS)

    Coelho, Ricardo Lopes

    2013-05-01

    It is generally accepted nowadays that History and Philosophy of Science (HPS) is useful in understanding scientific concepts, theories and even some experiments. Problem-solving strategies are a significant topic, since students' careers depend on their skill to solve problems. These are the reasons for addressing the question of whether problem solving could be improved by means of HPS. Three typical problems in introductory courses of mechanics—the inclined plane, the simple pendulum and the Atwood machine—are taken as the object of the present study. The solving strategies of these problems in the eighteenth and nineteenth century constitute the historical component of the study. Its philosophical component stems from the foundations of mechanics research literature. The use of HPS leads us to see those problems in a different way. These different ways can be tested, for which experiments are proposed. The traditional solving strategies for the incline and pendulum problems are adequate for some situations but not in general. The recourse to apparent weights in the Atwood machine problem leads us to a new insight and a solving strategy for composed Atwood machines. Educational implications also concern the development of logical thinking by means of the variety of lines of thought provided by HPS.

  4. Conceptual problem solving in high school physics

    NASA Astrophysics Data System (ADS)

    Docktor, Jennifer L.; Strand, Natalie E.; Mestre, José P.; Ross, Brian H.

    2015-12-01

    Problem solving is a critical element of learning physics. However, traditional instruction often emphasizes the quantitative aspects of problem solving such as equations and mathematical procedures rather than qualitative analysis for selecting appropriate concepts and principles. This study describes the development and evaluation of an instructional approach called Conceptual Problem Solving (CPS) which guides students to identify principles, justify their use, and plan their solution in writing before solving a problem. The CPS approach was implemented by high school physics teachers at three schools for major theorems and conservation laws in mechanics and CPS-taught classes were compared to control classes taught using traditional problem solving methods. Information about the teachers' implementation of the approach was gathered from classroom observations and interviews, and the effectiveness of the approach was evaluated from a series of written assessments. Results indicated that teachers found CPS easy to integrate into their curricula, students engaged in classroom discussions and produced problem solutions of a higher quality than before, and students scored higher on conceptual and problem solving measures.

  5. Innovative problem solving by wild spotted hyenas

    PubMed Central

    Benson-Amram, Sarah; Holekamp, Kay E.

    2012-01-01

    Innovative animals are those able to solve novel problems or invent novel solutions to existing problems. Despite the important ecological and evolutionary consequences of innovation, we still know very little about the traits that vary among individuals within a species to make them more or less innovative. Here we examine innovative problem solving by spotted hyenas (Crocuta crocuta) in their natural habitat, and demonstrate for the first time in a non-human animal that those individuals exhibiting a greater diversity of initial exploratory behaviours are more successful problem solvers. Additionally, as in earlier work, we found that neophobia was a critical inhibitor of problem-solving success. Interestingly, although juveniles and adults were equally successful in solving the problem, juveniles were significantly more diverse in their initial exploratory behaviours, more persistent and less neophobic than were adults. We found no significant effects of social rank or sex on success, the diversity of initial exploratory behaviours, behavioural persistence or neophobia. Our results suggest that the diversity of initial exploratory behaviours, akin to some measures of human creativity, is an important, but largely overlooked, determinant of problem-solving success in non-human animals. PMID:22874748

  6. Innovative problem solving by wild spotted hyenas.

    PubMed

    Benson-Amram, Sarah; Holekamp, Kay E

    2012-10-01

    Innovative animals are those able to solve novel problems or invent novel solutions to existing problems. Despite the important ecological and evolutionary consequences of innovation, we still know very little about the traits that vary among individuals within a species to make them more or less innovative. Here we examine innovative problem solving by spotted hyenas (Crocuta crocuta) in their natural habitat, and demonstrate for the first time in a non-human animal that those individuals exhibiting a greater diversity of initial exploratory behaviours are more successful problem solvers. Additionally, as in earlier work, we found that neophobia was a critical inhibitor of problem-solving success. Interestingly, although juveniles and adults were equally successful in solving the problem, juveniles were significantly more diverse in their initial exploratory behaviours, more persistent and less neophobic than were adults. We found no significant effects of social rank or sex on success, the diversity of initial exploratory behaviours, behavioural persistence or neophobia. Our results suggest that the diversity of initial exploratory behaviours, akin to some measures of human creativity, is an important, but largely overlooked, determinant of problem-solving success in non-human animals. PMID:22874748

  7. Why students still can't solve physics problems after solving over 2000 problems

    NASA Astrophysics Data System (ADS)

    Byun, Taejin; Lee, Gyoungho

    2014-09-01

    This study investigates the belief that solving a large number of physics problems helps students better learn physics. We investigated the number of problems solved, student confidence in solving these problems, academic achievement, and the level of conceptual understanding of 49 science high school students enrolled in upper-level physics classes from Spring 2010 to Summer 2011. The participants solved an average of 2200 physics problems before entering high school. Despite having solved so many problems, no statistically significant correlation was found between the number of problems solved and academic achievement on either a mid-term or physics competition examination. In addition, no significant correlation was found between the number of physics problems solved and performance on the Force Concept Inventory (FCI). Lastly, four students were selected from the 49 participants with varying levels of experience and FCI scores for a case study. We determined that their problem solving and learning strategies was more influential in their success than the number of problems they had solved.

  8. AI tools in computer based problem solving

    NASA Technical Reports Server (NTRS)

    Beane, Arthur J.

    1988-01-01

    The use of computers to solve value oriented, deterministic, algorithmic problems, has evolved a structured life cycle model of the software process. The symbolic processing techniques used, primarily in research, for solving nondeterministic problems, and those for which an algorithmic solution is unknown, have evolved a different model, much less structured. Traditionally, the two approaches have been used completely independently. With the advent of low cost, high performance 32 bit workstations executing identical software with large minicomputers and mainframes, it became possible to begin to merge both models into a single extended model of computer problem solving. The implementation of such an extended model on a VAX family of micro/mini/mainframe systems is described. Examples in both development and deployment of applications involving a blending of AI and traditional techniques are given.

  9. Problem solving in a distributed environment

    NASA Technical Reports Server (NTRS)

    Rashid, R. F.

    1980-01-01

    Distributed problem solving is anayzed as a blend of two disciplines: (1) problem solving and ai; and (2) distributed systems (monitoring). It may be necessary to distribute because the application itself is one of managing distributed resources (e.g., distributed sensor net) and communication delays preclude centralized processing, or it may be desirable to distribute because a single computational engine may not satisfy the needs of a given task. In addition, considerations of reliability may dictate distribution. Examples of multi-process language environment are given.

  10. Problem solving and decisionmaking: An integration

    NASA Technical Reports Server (NTRS)

    Dieterly, D. L.

    1980-01-01

    An attempt was made to redress a critical fault of decisionmaking and problem solving research-a lack of a standard method to classify problem or decision states or conditions. A basic model was identified and expanded to indicate a possible taxonomy of conditions which may be used in reviewing previous research or for systematically pursuing new research designs. A generalization of the basic conditions was then made to indicate that the conditions are essentially the same for both concepts, problem solving and decisionmaking.

  11. Problem solving with genetic algorithms and Splicer

    NASA Technical Reports Server (NTRS)

    Bayer, Steven E.; Wang, Lui

    1991-01-01

    Genetic algorithms are highly parallel, adaptive search procedures (i.e., problem-solving methods) loosely based on the processes of population genetics and Darwinian survival of the fittest. Genetic algorithms have proven useful in domains where other optimization techniques perform poorly. The main purpose of the paper is to discuss a NASA-sponsored software development project to develop a general-purpose tool for using genetic algorithms. The tool, called Splicer, can be used to solve a wide variety of optimization problems and is currently available from NASA and COSMIC. This discussion is preceded by an introduction to basic genetic algorithm concepts and a discussion of genetic algorithm applications.

  12. Solving coiled-coil protein structures

    DOE PAGESBeta

    Dauter, Zbigniew

    2015-02-26

    With the availability of more than 100,000 entries stored in the Protein Data Bank (PDB) that can be used as search models, molecular replacement (MR) is currently the most popular method of solving crystal structures of macromolecules. Significant methodological efforts have been directed in recent years towards making this approach more powerful and practical. This resulted in the creation of several computer programs, highly automated and user friendly, that are able to successfully solve many structures even by researchers who, although interested in structures of biomolecules, are not very experienced in crystallography.

  13. Partitioning SAT Instances for Distributed Solving

    NASA Astrophysics Data System (ADS)

    Hyvärinen, Antti E. J.; Junttila, Tommi; Niemelä, Ilkka

    In this paper we study the problem of solving hard propositional satisfiability problem (SAT) instances in a computing grid or cloud, where run times and communication between parallel running computations are limited.We study analytically an approach where the instance is partitioned iteratively into a tree of subproblems and each node in the tree is solved in parallel.We present new methods for constructing partitions which combine clause learning and lookahead. The methods are incorporated into the iterative approach and its performance is demonstrated with an extensive comparison against the best sequential solvers in the SAT competition 2009 as well as against two efficient parallel solvers.

  14. Solving inversion problems with neural networks

    NASA Technical Reports Server (NTRS)

    Kamgar-Parsi, Behzad; Gualtieri, J. A.

    1990-01-01

    A class of inverse problems in remote sensing can be characterized by Q = F(x), where F is a nonlinear and noninvertible (or hard to invert) operator, and the objective is to infer the unknowns, x, from the observed quantities, Q. Since the number of observations is usually greater than the number of unknowns, these problems are formulated as optimization problems, which can be solved by a variety of techniques. The feasibility of neural networks for solving such problems is presently investigated. As an example, the problem of finding the atmospheric ozone profile from measured ultraviolet radiances is studied.

  15. Problem-Solving Models for Computer Literacy: Getting Smarter at Solving Problems. Student Lessons.

    ERIC Educational Resources Information Center

    Moursund, David

    This book is intended for use as a student guide. It is about human problem solving and provides information on how the mind works, placing a major emphasis on the role of computers as an aid in problem solving. The book is written with the underlying philosophy of discovery-based learning based on two premises: first, through the appropriate…

  16. Understanding Individual Problem-Solving Style: A Key to Learning and Applying Creative Problem Solving

    ERIC Educational Resources Information Center

    Treffinger, Donald J.; Selby, Edwin C.; Isaksen, Scott G.

    2008-01-01

    More than five decades of research and development have focused on making the Creative Problem Solving process and tools accessible across a wide range of ages and contexts. Recent evidence indicates that when individuals, in both school and corporate settings, understand their own style of problem solving, they are able to learn and apply process…

  17. The Effect of Learning Environments Based on Problem Solving on Students' Achievements of Problem Solving

    ERIC Educational Resources Information Center

    Karatas, Ilhan; Baki, Adnan

    2013-01-01

    Problem solving is recognized as an important life skill involving a range of processes including analyzing, interpreting, reasoning, predicting, evaluating and reflecting. For that reason educating students as efficient problem solvers is an important role of mathematics education. Problem solving skill is the centre of mathematics curriculum.…

  18. Encouraging Sixth-Grade Students' Problem-Solving Performance by Teaching through Problem Solving

    ERIC Educational Resources Information Center

    Bostic, Jonathan D.; Pape, Stephen J.; Jacobbe, Tim

    2016-01-01

    This teaching experiment provided students with continuous engagement in a problem-solving based instructional approach during one mathematics unit. Three sections of sixth-grade mathematics were sampled from a school in Florida, U.S.A. and one section was randomly assigned to experience teaching through problem solving. Students' problem-solving…

  19. Students' Errors in Solving the Permutation and Combination Problems Based on Problem Solving Steps of Polya

    ERIC Educational Resources Information Center

    Sukoriyanto; Nusantara, Toto; Subanji; Chandra, Tjang Daniel

    2016-01-01

    This article was written based on the results of a study evaluating students' errors in problem solving of permutation and combination in terms of problem solving steps according to Polya. Twenty-five students were asked to do four problems related to permutation and combination. The research results showed that the students still did a mistake in…

  20. Assessing Affect after Mathematical Problem Solving Tasks: Validating the Chamberlin Affective Instrument for Mathematical Problem Solving

    ERIC Educational Resources Information Center

    Chamberlin, Scott A.; Powers, Robert A.

    2013-01-01

    The focus of the article is the validation of an instrument to assess gifted students' affect after mathematical problem solving tasks. Participants were 225 students identified by their district as gifted in grades four to six. The Chamberlin Affective Instrument for Mathematical Problem Solving was used to assess feelings, emotions, and…

  1. Preschoolers' Cooperative Problem Solving: Integrating Play and Problem Solving

    ERIC Educational Resources Information Center

    Ramani, Geetha B.; Brownell, Celia A.

    2014-01-01

    Cooperative problem solving with peers plays a central role in promoting children's cognitive and social development. This article reviews research on cooperative problem solving among preschool-age children in experimental settings and social play contexts. Studies suggest that cooperative interactions with peers in experimental settings are…

  2. Computer Enhanced Problem Solving Skill Acquisition.

    ERIC Educational Resources Information Center

    Slotnick, Robert S.

    1989-01-01

    Discusses the implementation of interactive educational software that was designed to enhance critical thinking, scientific reasoning, and problem solving in a university psychology course. Piagetian and computer learning perspectives are explained; the courseware package, PsychWare, is described; and the use of heuristics and algorithms in…

  3. ADHD and Problem-Solving in Play

    ERIC Educational Resources Information Center

    Borg, Suzanne

    2009-01-01

    This paper reports a small-scale study to determine whether there is a difference in problem-solving abilities, from a play perspective, between individuals who are diagnosed as ADHD and are on medication and those not on medication. Ten children, five of whom where on medication and five not, diagnosed as ADHD predominantly inattentive type, were…

  4. Correlates of Problem-Solving Flexibility.

    ERIC Educational Resources Information Center

    Greenberger, Ellen; And Others

    Problem solving flexibility (PSF), an ability commonly assessed in creativity batteries, was studied in a sample of middle class children (grades 1 through 3, average IQ 114), tested on questions resembling Guilford's consequences procedure. An hypothesis linking PSF with alertness to and interest in the environment was generally supported, more…

  5. Problem-Solving Skills for Office Supervisors.

    ERIC Educational Resources Information Center

    Hathaway, Sandy

    This package contains a selection of exercises designed to facilitate learning of problem-solving/communication skills within the area of office supervision. It does not provide the learning material or lesson plans. Section 1 is an overview that explains the scope of the material, learning methods, use of the teaching package, teaching resources,…

  6. Euler's Amazing Way to Solve Equations.

    ERIC Educational Resources Information Center

    Flusser, Peter

    1992-01-01

    Presented is a series of examples that illustrate a method of solving equations developed by Leonhard Euler based on an unsubstantiated assumption. The method integrates aspects of recursion relations and sequences of converging ratios and can be extended to polynomial equation with infinite exponents. (MDH)

  7. Complex Problem Solving--More than Reasoning?

    ERIC Educational Resources Information Center

    Wustenberg, Sascha; Greiff, Samuel; Funke, Joachim

    2012-01-01

    This study investigates the internal structure and construct validity of Complex Problem Solving (CPS), which is measured by a "Multiple-Item-Approach." It is tested, if (a) three facets of CPS--"rule identification" (adequateness of strategies), "rule knowledge" (generated knowledge) and "rule application" (ability to control a system)--can be…

  8. Task Variables in Mathematical Problem Solving.

    ERIC Educational Resources Information Center

    Goldin, Gerald A., Ed.; McClintock, C. Edwin, Ed.

    A framework for research in problem solving is provided by categorizing and defining variables describing problem tasks. A model is presented in an article by Kulm for the classification of task variables into broad categories. The model attempts to draw realtionships between these categories of task variables and the stages of problem solving…

  9. The Functional Equivalence of Problem Solving Skills

    ERIC Educational Resources Information Center

    Simon, Herbert A.

    1975-01-01

    This analysis of solutions to the Tower of Hanoi Problem underscores the importance of subject-by-subject analysis of "What is learned" in understanding human behavior in problem-solving situations, and provides a technique for describing subjects' task performance programs in detail. (Author/BJG)

  10. Using Bibliotherapy To Teach Problem Solving.

    ERIC Educational Resources Information Center

    Forgan, James W.

    2002-01-01

    This article discusses how students with high-incidence disabilities can benefit from using bibliotherapy by learning to become proactive problem solvers. A sample lesson plan is presented based on a teaching framework for bibliotherapy and problem solving that contains the elements of prereading, guided reading, post-reading discussion, and a…

  11. Solves the Multigroup Neutron Diffusion Equation

    Energy Science and Technology Software Center (ESTSC)

    1995-06-23

    GNOMER is a program which solves the multigroup neutron diffusion equation in 1D, 2D and 3D cartesian geometry. The program is designed to calculate the global core power distributions (with thermohydraulic feedbacks), as well as power distribution and homogenized cross sections over a fuel assembly.

  12. Solving Absolute Value Equations Algebraically and Geometrically

    ERIC Educational Resources Information Center

    Shiyuan, Wei

    2005-01-01

    The way in which students can improve their comprehension by understanding the geometrical meaning of algebraic equations or solving algebraic equation geometrically is described. Students can experiment with the conditions of the absolute value equation presented, for an interesting way to form an overall understanding of the concept.

  13. Option X, Level B Problem Solving.

    ERIC Educational Resources Information Center

    Hawaii State Dept. of Education, Honolulu. Office of Instructional Services.

    This guide outlines an Option X course on problem solving techniques. The 16 learner objectives identified in the Mathematics Program Guide stress applications orientation to concepts about numbers and operations and common plane and solid figures. Techniques covered include working with diagrams, organizing information, using patterns,…

  14. Design and Problem Solving in Technology Education.

    ERIC Educational Resources Information Center

    Custer, Rodney L.

    1999-01-01

    Collectively, technological literacy embraces everything from intelligent consumerism to concerns about environmental degradation, ethics, and elitism. Technological problem solving can have social, ecological, or technological goals and may be categorized by four types: invention, design, trouble shooting, and procedures. Every citizen should be…

  15. Taylor series to solve friction problems

    NASA Astrophysics Data System (ADS)

    Béchet, Fabien; Lejeune, Arnaud; Potier-Ferry, Michel

    2010-06-01

    Thin metallic sheet transportation appears in numerous manufacturing processes such as continuous annealing, levelling or galvanization. It involves various nonlinear phenomena and, in particular, contact with friction. We develop a numerical method to solve this kind of mechanical problem, using shell finite elements and the Asymptotic Numerical Method (ANM). This article focuses on the treatment of the friction equations with ANM.

  16. Assessing Mathematical Problem Solving Using Comparative Judgement

    ERIC Educational Resources Information Center

    Jones, Ian; Swan, Malcolm; Pollitt, Alastair

    2015-01-01

    There is an increasing demand from employers and universities for school leavers to be able to apply their mathematical knowledge to problem solving in varied and unfamiliar contexts. These aspects are however neglected in most examinations of mathematics and, consequentially, in classroom teaching. One barrier to the inclusion of mathematical…

  17. Solving Rational Expectations Models Using Excel

    ERIC Educational Resources Information Center

    Strulik, Holger

    2004-01-01

    Simple problems of discrete-time optimal control can be solved using a standard spreadsheet software. The employed-solution method of backward iteration is intuitively understandable, does not require any programming skills, and is easy to implement so that it is suitable for classroom exercises with rational-expectations models. The author…

  18. Collaborative Problem Solving in Shared Space

    ERIC Educational Resources Information Center

    Lin, Lin; Mills, Leila A.; Ifenthaler, Dirk

    2015-01-01

    The purpose of this study was to examine collaborative problem solving in a shared virtual space. The main question asked was: How will the performance and processes differ between collaborative problem solvers and independent problem solvers over time? A total of 104 university students (63 female and 41 male) participated in an experimental…

  19. Problem Solving: Can Anybody Do It?

    ERIC Educational Resources Information Center

    Bennett, Stuart W.

    2008-01-01

    This paper examines the definition of a problem and at the process of problem solving. An analysis of a number of first and third year chemistry examination papers from English universities revealed that over ninety per cent of the "problems" fell into the "algorithm" category. Using Bloom's taxonomy and the same examination papers, we found that…

  20. Making Problem-Solving Simulations More Realistic.

    ERIC Educational Resources Information Center

    Cotton, Samuel E.

    2002-01-01

    Many problem-solving activities include mathematical principles but students do not use them during the design and experimentation phases before creating a prototype or product. Restricting the amount and/or type of materials available to students will require them to calculate and requisition the materials needed. (JOW)

  1. Using CAS to Solve Classical Mathematics Problems

    ERIC Educational Resources Information Center

    Burke, Maurice J.; Burroughs, Elizabeth A.

    2009-01-01

    Historically, calculus has displaced many algebraic methods for solving classical problems. This article illustrates an algebraic method for finding the zeros of polynomial functions that is closely related to Newton's method (devised in 1669, published in 1711), which is encountered in calculus. By exploring this problem, precalculus students…

  2. Models of Strategy for Solving Physics Problems.

    ERIC Educational Resources Information Center

    Larkin, Jill H.

    A set of computer implemented models are presented which can assist in developing problem solving strategies. The three levels of expertise which are covered are beginners (those who have completed at least one university physics course), intermediates (university level physics majors in their third year of study), and professionals (university…

  3. Problem-Solving Test: Southwestern Blotting

    ERIC Educational Resources Information Center

    Szeberényi, József

    2014-01-01

    Terms to be familiar with before you start to solve the test: Southern blotting, Western blotting, restriction endonucleases, agarose gel electrophoresis, nitrocellulose filter, molecular hybridization, polyacrylamide gel electrophoresis, proto-oncogene, c-abl, Src-homology domains, tyrosine protein kinase, nuclear localization signal, cDNA,…

  4. Is Problem Solving Dependent on Language?

    ERIC Educational Resources Information Center

    Baldo, J.V.; Dronkers, N.F.; Wilkins, D.; Ludy, C.; Raskin, P.; Kim, J.

    2005-01-01

    There has been a long-standing debate in the fields of philosophy and cognitive science surrounding the relationship of language to cognition, but the exact nature of this relationship is still unclear (Sokolov, 1968/1972). In the current study, we explored the role of language in one aspect of cognition, namely problem solving, by administering…

  5. Teaching, Learning and Assessing Statistical Problem Solving

    ERIC Educational Resources Information Center

    Marriott, John; Davies, Neville; Gibson, Liz

    2009-01-01

    In this paper we report the results from a major UK government-funded project, started in 2005, to review statistics and handling data within the school mathematics curriculum for students up to age 16. As a result of a survey of teachers we developed new teaching materials that explicitly use a problem-solving approach for the teaching and…

  6. Structural and Linguistic Variables in Problem Solving.

    ERIC Educational Resources Information Center

    Jerman, Max; Mirman, Sanford

    This paper reports on an experiment designed to investigate the effect of structural and linguistic variables on level of difficulty in solving arithmetic word problems. Identification of such variables is intended to assist curriculum writers in preparing exercises at a specified level of difficulty for students at various age levels. The study…

  7. GIS Live and Web Problem Solving

    ERIC Educational Resources Information Center

    Hagevik, R.; Hales, D.; Harrell, J.

    2007-01-01

    GIS Live is a live, interactive, web problem-solving (WPS) program that partners Geographic Information Systems (GIS) professionals with educators to implement geospatial technologies as curriculum-learning tools. It is a collaborative effort of many government agencies, educational institutions, and professional organizations. Problem-based…

  8. Collaborative Problem Solving Methods towards Critical Thinking

    ERIC Educational Resources Information Center

    Yin, Khoo Yin; Abdullah, Abdul Ghani Kanesan; Alazidiyeen, Naser Jamil

    2011-01-01

    This research attempts to examine the collaborative problem solving methods towards critical thinking based on economy (AE) and non economy (TE) in the SPM level among students in the lower sixth form. The quasi experiment method that uses the modal of 3X2 factorial is applied. 294 lower sixth form students from ten schools are distributed…

  9. Effective Practices (Part 4): Problem Solving.

    ERIC Educational Resources Information Center

    Moursund, Dave

    1996-01-01

    Discusses the use of computers to help with problem solving. Topics include information science, including effective procedure and procedural thinking; templates; artificially intelligent agents and expert systems; and applications in education, including the goal of computer literacy for all students, and integrated software packages such as…

  10. Using Programmable Calculators to Solve Electrostatics Problems.

    ERIC Educational Resources Information Center

    Yerian, Stephen C.; Denker, Dennis A.

    1985-01-01

    Provides a simple routine which allows first-year physics students to use programmable calculators to solve otherwise complex electrostatic problems. These problems involve finding electrostatic potential and electric field on the axis of a uniformly charged ring. Modest programing skills are required of students. (DH)

  11. Nanomedicine: Problem Solving to Treat Cancer

    ERIC Educational Resources Information Center

    Hemling, Melissa A.; Sammel, Lauren M.; Zenner, Greta; Payne, Amy C.; Crone, Wendy C.

    2006-01-01

    Many traditional classroom science and technology activities often ask students to complete prepackaged labs that ensure that everyone arrives at the same "scientifically accurate" solution or theory, which ignores the important problem-solving and creative aspects of scientific research and technological design. Students rarely have the…

  12. Partial Metacognitive Blindness in Collaborative Problem Solving

    ERIC Educational Resources Information Center

    Ng, Kit Ee Dawn

    2010-01-01

    This paper investigates the impact of group dynamics on metacognitive behaviours of students (aged 13-14) during group collaborative problem solving attempts involving a design-based real-world applications project. It was discovered that group dynamics mediated the impact of metacognitive judgments related red flag situations and metacognitive…

  13. Problem-Solving Competitions: Just the Solution!

    ERIC Educational Resources Information Center

    Riley, Tracy L.; Karnes, Frances A.

    2005-01-01

    This article describes competitions across a range of curricular areas that develop students' problem solving skills by setting authentic, real-world tasks. As individuals or members of a team, students in these competitions are challenged with finding solutions to problems faced not only in today's scientific and technological world, but also in…

  14. Spatial Visualization in Physics Problem Solving

    ERIC Educational Resources Information Center

    Kozhevnikov, Maria; Motes, Michael A.; Hegarty, Mary

    2007-01-01

    Three studies were conducted to examine the relation of spatial visualization to solving kinematics problems that involved either predicting the two-dimensional motion of an object, translating from one frame of reference to another, or interpreting kinematics graphs. In Study 1, 60 physics-naive students were administered kinematics problems and…

  15. Probelm Solving in Pre-Operational Youngsters.

    ERIC Educational Resources Information Center

    Zetlin, Andrea G.

    1981-01-01

    The problem solving behavior of three groups of trainable retarded youngsters (N=54) and three groups of intellectually average children (N=54) of comparable mental age was examined to determine individual differences in task performance within and between populations and the effect of prompting cues on the performance of those students who do not…

  16. Solving Wicked Problems through Action Learning

    ERIC Educational Resources Information Center

    Crul, Liselore

    2014-01-01

    This account of practice outlines the Oxyme Action Learning Program which was conducted as part of the Management Challenge in my final year of the MSc in Coaching and Behavioral Change at Henley Business School. The central research questions were: (1) how action learning can help to solve wicked problems and (2) what the effect of an action…

  17. Teaching Teamwork and Problem Solving Concurrently

    ERIC Educational Resources Information Center

    Goltz, Sonia M.; Hietapelto, Amy B.; Reinsch, Roger W.; Tyrell, Sharon K.

    2008-01-01

    Teamwork and problem-solving skills have frequently been identified by business leaders as being key competencies; thus, teaching methods such as problem-based learning and team-based learning have been developed. However, the focus of these methods has been on teaching one skill or the other. A key argument for teaching the skills concurrently is…

  18. Problem-solving for better health.

    PubMed

    Smith, B; Barnett, S; Collado, D; Connor, M; DePasquale, J; Gross, L; McDermott, V; Sykes, A

    1994-01-01

    An outline is given of an approach to the health-for-all goals which involves optimizing resource use, prioritizing people's well-being, achieving excellence and a measurable impact at all levels of care, and solving health problems in a broad developmental context. PMID:8141991

  19. Pose and Solve Varignon Converse Problems

    ERIC Educational Resources Information Center

    Contreras, José N.

    2014-01-01

    The activity of posing and solving problems can enrich learners' mathematical experiences because it fosters a spirit of inquisitiveness, cultivates their mathematical curiosity, and deepens their views of what it means to do mathematics. To achieve these goals, a mathematical problem needs to be at the appropriate level of difficulty,…

  20. Reinventing the Wheel: Design and Problem Solving

    ERIC Educational Resources Information Center

    Blasetti, Sean M.

    2010-01-01

    This article describes a design problem that not only takes students through the technological design process, but it also provides them with real-world problem-solving experience as it relates to the manufacturing and engineering fields. It begins with a scenario placing the student as a custom wheel designer for an automotive manufacturing…

  1. Problem? "No Problem!" Solving Technical Contradictions

    ERIC Educational Resources Information Center

    Kutz, K. Scott; Stefan, Victor

    2007-01-01

    TRIZ (pronounced TREES), the Russian acronym for the theory of inventive problem solving, enables a person to focus his attention on finding genuine, potential solutions in contrast to searching for ideas that "may" work through a happenstance way. It is a patent database-backed methodology that helps to reduce time spent on the problem,…

  2. How Instructional Designers Solve Workplace Problems

    ERIC Educational Resources Information Center

    Fortney, Kathleen S.; Yamagata-Lynch, Lisa C.

    2013-01-01

    This naturalistic inquiry investigated how instructional designers engage in complex and ambiguous problem solving across organizational boundaries in two corporations. Participants represented a range of instructional design experience, from novices to experts. Research methods included a participant background survey, observations of…

  3. Problem Solving. Workplace Education Program Curriculum.

    ERIC Educational Resources Information Center

    Burkhart, Jennifer

    The BUILD Program (Businesses United to Increase Literacy Development) was conducted from June 1991 through December 1992 as a cooperative workplace literacy program joining Arapahoe Community College and four companies in Littleton, Colorado. This document consists of three modules for the problem-solving and computer learning systems classes of…

  4. The Use of Transformations in Solving Equations

    ERIC Educational Resources Information Center

    Libeskind, Shlomo

    2010-01-01

    Many workshops and meetings with the US high school mathematics teachers revealed a lack of familiarity with the use of transformations in solving equations and problems related to the roots of polynomials. This note describes two transformational approaches to the derivation of the quadratic formula as well as transformational approaches to…

  5. Student Problem Solving in High School Genetics.

    ERIC Educational Resources Information Center

    Stewart, James

    1983-01-01

    Describes set of specific steps (procedural knowledge) used when solving monohybrid/dihybrid cross problems and extent to which students could justify execution of each step in terms of their conceptual knowledge of genetics and meiosis. Implications for genetics instruction are discussed. (JN)

  6. Insightful problem solving in an Asian elephant.

    PubMed

    Foerder, Preston; Galloway, Marie; Barthel, Tony; Moore, Donald E; Reiss, Diana

    2011-01-01

    The "aha" moment or the sudden arrival of the solution to a problem is a common human experience. Spontaneous problem solving without evident trial and error behavior in humans and other animals has been referred to as insight. Surprisingly, elephants, thought to be highly intelligent, have failed to exhibit insightful problem solving in previous cognitive studies. We tested whether three Asian elephants (Elephas maximus) would use sticks or other objects to obtain food items placed out-of-reach and overhead. Without prior trial and error behavior, a 7-year-old male Asian elephant showed spontaneous problem solving by moving a large plastic cube, on which he then stood, to acquire the food. In further testing he showed behavioral flexibility, using this technique to reach other items and retrieving the cube from various locations to use as a tool to acquire food. In the cube's absence, he generalized this tool utilization technique to other objects and, when given smaller objects, stacked them in an attempt to reach the food. The elephant's overall behavior was consistent with the definition of insightful problem solving. Previous failures to demonstrate this ability in elephants may have resulted not from a lack of cognitive ability but from the presentation of tasks requiring trunk-held sticks as potential tools, thereby interfering with the trunk's use as a sensory organ to locate the targeted food. PMID:21876741

  7. Facilitating problem solving in high school chemistry

    NASA Astrophysics Data System (ADS)

    Gabel, Dorothy L.; Sherwood, Robert D.

    The major purpose for conducting this study was to determine whether certain instructional strategies were superior to others in teaching high school chemistry students problem solving. The effectiveness of four instructional strategies for teaching problem solving to students of various proportional reasoning ability, verbal and visual preference, and mathematics anxiety were compared in this aptitude by treatment interaction study. The strategies used were the factor-label method, analogies, diagrams, and proportionality. Six hundred and nine high school students in eight schools were randomly assigned to one of four teaching strategies within each classroom. Students used programmed booklets to study the mole concept, the gas laws, stoichiometry, and molarity. Problem-solving ability was measured by a series of immediate posttests, delayed posttests and the ACS-NSTA Examination in High School Chemistry. Results showed that mathematics anxiety is negatively correlated with science achievement and that problem solving is dependent on students' proportional reasoning ability. The factor-label method was found to be the most desirable method and proportionality the least desirable method for teaching the mole concept. However, the proportionality method was best for teaching the gas laws. Several second-order interactions were found to be significant when mathematics anxiety was one of the aptitudes involved.

  8. Reflect ... for Better Problem Solving and Reasoning.

    ERIC Educational Resources Information Center

    Krulik, Stephen; Rudnick, Jesse A.

    1994-01-01

    Elaborates the final step of Polya's heuristic model, reflecting, to improve students' problem-solving performance. After checking answers for accuracy, the following steps are suggested: (1) test reasonableness and practicality; (2) write a summary paragraph; (3) find other solutions; (4) change the conditions; and (5) extend the problem. (MKR)

  9. Raise the Bar on Problem Solving

    ERIC Educational Resources Information Center

    Englard, Lisa

    2010-01-01

    In a 1981 diagnostic test, the Ministry of Education in Singapore found its country facing a challenge: Only 46 percent of students in grades 2-4 could solve word problems that were presented without such key words as "altogether" or "left." Yet today, according to results from the Trends in International Mathematics and Science Study (TIMSS…

  10. Informal Evaluation Strategies for Real Problem Solving

    ERIC Educational Resources Information Center

    Ellis, Arthur K.; Alleman-Brooks, Janet

    1978-01-01

    Examples of possible methods for unobtrusively evaluating student progress through real problem solving outcomes without formal testing are illustrated. These methods include the use of interviews, artifacts, observations, I learned statements, checklists, flow of discussion charts, and self-awareness exercises. (MN)

  11. Mental Imagery in Creative Problem Solving.

    ERIC Educational Resources Information Center

    Polland, Mark J.

    In order to investigate the relationship between mental imagery and creative problem solving, a study of 44 separate accounts reporting mental imagery experiences associated with creative discoveries were examined. The data included 29 different scientists, among them Albert Einstein and Stephen Hawking, and 9 artists, musicians, and writers,…

  12. Problem Solving and Behavior Therapy Revisited

    ERIC Educational Resources Information Center

    Nezu, Arthur M.

    2004-01-01

    Over three decades ago, D'Zurilla and Goldfried (1971) published a seminal article delineating a model of problem-solving training geared to enhance social competence and decrease psychological distress. Since that time, a substantial amount of research has been conducted to test various hypotheses that this model has engendered. Much of this…

  13. Should Children Learn to Solve Problems?

    ERIC Educational Resources Information Center

    Watras, Joseph

    2011-01-01

    In this comparative essay, the author discusses the opposing educational theories of John Dewey and Gregory Bateson. While Dewey believed that the scientific method was the dominant method of solving problems and thereby acquiring knowledge that mattered, Bateson warned that this one-sided approach would lead to actions that could destroy the…

  14. Synthesizing Strategies Creatively: Solving Linear Equations

    ERIC Educational Resources Information Center

    Ponce, Gregorio A.; Tuba, Imre

    2015-01-01

    New strategies can ignite teachers' imagination to create new lessons or adapt lessons created by others. In this article, the authors present the experience of an algebra teacher and his students solving linear and literal equations and explain how the use of ideas found in past NCTM journals helped bring this lesson to life. The…

  15. Problem-Solving Test: Tryptophan Operon Mutants

    ERIC Educational Resources Information Center

    Szeberenyi, Jozsef

    2010-01-01

    This paper presents a problem-solving test that deals with the regulation of the "trp" operon of "Escherichia coli." Two mutants of this operon are described: in mutant A, the operator region of the operon carries a point mutation so that it is unable to carry out its function; mutant B expresses a "trp" repressor protein unable to bind…

  16. A Versatile Technique for Solving Quintic Equations

    ERIC Educational Resources Information Center

    Kulkarni, Raghavendra G.

    2006-01-01

    In this paper we present a versatile technique to solve several types of solvable quintic equations. In the technique described here, the given quintic is first converted to a sextic equation by adding a root, and the resulting sextic equation is decomposed into two cubic polynomials as factors in a novel fashion. The resultant cubic equations are…

  17. Instruction Emphasizing Effort Improves Physics Problem Solving

    ERIC Educational Resources Information Center

    Li, Daoquan

    2012-01-01

    Effectively using strategies to solve complex problems is an important educational goal and is implicated in successful academic performance. However, people often do not spontaneously use the effective strategies unless they are motivated to do so. The present study was designed to test whether educating students about the importance of effort in…

  18. A SURVEY OF PROBLEM-SOLVING COURSES.

    ERIC Educational Resources Information Center

    EDWARDS, M.O.

    TO DETERMINE THE DESIRABILITY OF HAVING ITS OWN CREATIVITY COURSE, THE STANFORD RESEARCH INSTITUTE SURVEYED 43 ORGANIZATIONS ON THEIR PROBLEM SOLVING COURSES. FIFTEEN INDUSTRIAL CORPORATIONS, FOUR CONSULTING FIRMS, A GOVERNMENT AGENCY, A RESEARCH CORPORATION, AND NINE COLLEGES AND UNIVERSITIES RESPONDED WITH SPECIFIC INFORMATION ON COURSE LENGTH…

  19. Solving Problems with the Percentage Bar

    ERIC Educational Resources Information Center

    van Galen, Frans; van Eerde, Dolly

    2013-01-01

    At the end of primary school all children more of less know what a percentage is, but yet they often struggle with percentage problems. This article describes a study in which students of 13 and 14 years old were given a written test with percentage problems and a week later were interviewed about the way they solved some of these problems. In a…

  20. ARPACK: Solving large scale eigenvalue problems

    NASA Astrophysics Data System (ADS)

    Lehoucq, Rich; Maschhoff, Kristi; Sorensen, Danny; Yang, Chao

    2013-11-01

    ARPACK is a collection of Fortran77 subroutines designed to solve large scale eigenvalue problems. The package is designed to compute a few eigenvalues and corresponding eigenvectors of a general n by n matrix A. It is most appropriate for large sparse or structured matrices A where structured means that a matrix-vector product w

  1. Solving Geometry Problems via Mechanical Principles

    ERIC Educational Resources Information Center

    Man, Yiu Kwong

    2004-01-01

    The application of physical principles in solving mathematics problems have often been neglected in the teaching of physics or mathematics, especially at the secondary school level. This paper discusses how to apply the mechanical principles to geometry problems via concrete examples, which aims at providing insight and inspirations to physics or…

  2. Model Formulation for Physics Problem Solving. Draft.

    ERIC Educational Resources Information Center

    Novak, Gordon S., Jr.

    The major task in solving a physics problem is to construct an appropriate model of the problem in terms of physical principles. The functions performed by such a model, the information which needs to be represented, and the knowledge used in selecting and instantiating an appropriate model are discussed. An example of a model for a mechanics…

  3. Colorado Assessment of Problem Solving (CAPS) -- Identifying student's problem solving skills

    NASA Astrophysics Data System (ADS)

    Adams, Wendy; Wieman, Carl

    2009-05-01

    Problem solving is central to any physics curriculum and physics educators have put extensive effort into understanding successful problem solving; however, there is currently no efficient way to evaluate problem solving skill. Attempts have been made in the past; however, knowledge of the principles required to solve the subject problem are so absolutely critical that they completely overshadow any other skills students may use when solving a problem. The work presented here is unique because CAPS removes the requirement that the student already have a grasp of physics concepts. CAPS has been developed and validated at Colorado and measures a person's competence in 44 separate skills that are used when solving a wide range of in-depth problems including classical mechanics and quantum mechanics problems. Understanding the specific processes that impact how a person solves a problem identifies which components are specific to physics and those that transfer across discipline, and provides insight for improved methods for teaching. 1. Supported in part by funding from National Science Foundation

  4. Interactive Problem Solving Tutorials Through Visual Programming

    NASA Astrophysics Data System (ADS)

    Undreiu, Lucian; Schuster, David; Undreiu, Adriana

    2008-10-01

    We have used LabVIEW visual programming to build an interactive tutorial to promote conceptual understanding in physics problem solving. This programming environment is able to offer a web-accessible problem solving experience that enables students to work at their own pace and receive feedback. Intuitive graphical symbols, modular structures and the ability to create templates are just a few of the advantages this software has to offer. The architecture of an application can be designed in a way that allows instructors with little knowledge of LabVIEW to easily personalize it. Both the physics solution and the interactive pedagogy can be visually programmed in LabVIEW. Our physics pedagogy approach is that of cognitive apprenticeship, in that the tutorial guides students to develop conceptual understanding and physical insight into phenomena, rather than purely formula-based solutions. We demonstrate how this model is reflected in the design and programming of the interactive tutorials.

  5. Solving Problems in Genetics II: Conceptual restructuring

    NASA Astrophysics Data System (ADS)

    Ibáñez Orcajo, Teresa; Martínez Aznar, Mercedes

    2005-10-01

    This paper presents the results of part of an investigation carried out with fourth-level Spanish secondary education students (15 years old), in which we implemented a teaching unit based on problem-solving methodology as an investigation to teach genetics and human inheritance curricular contents. By solving open problems, the students experienced a conceptual restructuring that stayed with them over time and involved the following specific theories: the location of hereditary information, the transmission of hereditary information, and the appearance of new characteristic. The learning connections between these specific theories were also studied. Furthermore, these results were compared with a control group that worked with closed problems, the usual approach to genetics teaching in Spanish classrooms. Consequently, we were able to verify that our methodology results in better learning.

  6. Solving ptychography with a convex relaxation

    PubMed Central

    Chen, Richard Y; Ou, Xiaoze; Ames, Brendan; Tropp, Joel A; Yang, Changhuei

    2015-01-01

    Ptychography is a powerful computational imaging technique that transforms a collection of low-resolution images into a high-resolution sample reconstruction. Unfortunately, algorithms that currently solve this reconstruction problem lack stability, robustness, and theoretical guarantees. Recently, convex optimization algorithms have improved the accuracy and reliability of several related reconstruction efforts. This paper proposes a convex formulation of the ptychography problem. This formulation has no local minima, it can be solved using a wide range of algorithms, it can incorporate appropriate noise models, and it can include multiple a priori constraints. The paper considers a specific algorithm, based on low-rank factorization, whose runtime and memory usage are near-linear in the size of the output image. Experiments demonstrate that this approach offers a 25% lower background variance on average than alternating projections, the ptychographic reconstruction algorithm that is currently in widespread use. PMID:26146480

  7. Black Carbon Measurements in SOLVE-2

    NASA Technical Reports Server (NTRS)

    Kok, Gregory L.; Baumgardner, Darrel R.

    2004-01-01

    Droplet Measurement Technologies (DMT), under funding from NASA s Radiation Sciences Program, participated in the SOLVE II field campaign with measurements of light absorbing particles (black carbon and metals). These measurements were made with the Single Particle Soot Photometer (SP-2) on the NASA DC-8. The SP-2 is a new measurement technique that was developed under the SBIR program with funding from the Office of Naval Research. The original instrument suite for the DC-8 did not include the SP-2 and its addition and operation during SOLVE II was intended solely as a means to test its functionality and prepare it for future flight operations. For this reason it required several flights in the early stages of the project to tune its operation and fix some problems that arose. During the flights of January 26, 29, and 30, and February 2, 4 and 6, however, it worked as designed and acquired credible data.

  8. Solving multiconstraint assignment problems using learning automata.

    PubMed

    Horn, Geir; Oommen, B John

    2010-02-01

    This paper considers the NP-hard problem of object assignment with respect to multiple constraints: assigning a set of elements (or objects) into mutually exclusive classes (or groups), where the elements which are "similar" to each other are hopefully located in the same class. The literature reports solutions in which the similarity constraint consists of a single index that is inappropriate for the type of multiconstraint problems considered here and where the constraints could simultaneously be contradictory. This feature, where we permit possibly contradictory constraints, distinguishes this paper from the state of the art. Indeed, we are aware of no learning automata (or other heuristic) solutions which solve this problem in its most general setting. Such a scenario is illustrated with the static mapping problem, which consists of distributing the processes of a parallel application onto a set of computing nodes. This is a classical and yet very important problem within the areas of parallel computing, grid computing, and cloud computing. We have developed four learning-automata (LA)-based algorithms to solve this problem: First, a fixed-structure stochastic automata algorithm is presented, where the processes try to form pairs to go onto the same node. This algorithm solves the problem, although it requires some centralized coordination. As it is desirable to avoid centralized control, we subsequently present three different variable-structure stochastic automata (VSSA) algorithms, which have superior partitioning properties in certain settings, although they forfeit some of the scalability features of the fixed-structure algorithm. All three VSSA algorithms model the processes as automata having first the hosting nodes as possible actions; second, the processes as possible actions; and, third, attempting to estimate the process communication digraph prior to probabilistically mapping the processes. This paper, which, we believe, comprehensively reports the

  9. DC-8 MTP calibration for SOLVE-2

    NASA Technical Reports Server (NTRS)

    Mahoney, M. J.

    2003-01-01

    The Jet Propulsion Laboratory (JPL) Microwave Temperature Profiler (MTP) was the only instrument making temperature measurements at and below flight level on the DC-8 during the SOLVE-2 campaign. Many years of careful comparison of MTP measurements with radiosondes near the DC-8 flight track have shown that the flight level temperature can be determined to an accuracy of 0.2K relative to radiosondes.

  10. Analytical methods for solving the Boltzmann equation

    NASA Astrophysics Data System (ADS)

    Struminskii, V. V.

    The principal analytical methods for solving the Boltzmann equation are reviewed, and a very general solution is proposed. The method makes it possible to obtain a solution to the Cauchy problem for the nonlinear Boltzmann equation and thus determine the applicability regions for the various analytical methods. The method proposed here also makes it possible to demonstrate that Hilbert's theorem of macroscopic causality does not apply and Hilbert's paradox does not exist.

  11. Optimal Planning and Problem-Solving

    NASA Technical Reports Server (NTRS)

    Clemet, Bradley; Schaffer, Steven; Rabideau, Gregg

    2008-01-01

    CTAEMS MDP Optimal Planner is a problem-solving software designed to command a single spacecraft/rover, or a team of spacecraft/rovers, to perform the best action possible at all times according to an abstract model of the spacecraft/rover and its environment. It also may be useful in solving logistical problems encountered in commercial applications such as shipping and manufacturing. The planner reasons around uncertainty according to specified probabilities of outcomes using a plan hierarchy to avoid exploring certain kinds of suboptimal actions. Also, planned actions are calculated as the state-action space is expanded, rather than afterward, to reduce by an order of magnitude the processing time and memory used. The software solves planning problems with actions that can execute concurrently, that have uncertain duration and quality, and that have functional dependencies on others that affect quality. These problems are modeled in a hierarchical planning language called C_TAEMS, a derivative of the TAEMS language for specifying domains for the DARPA Coordinators program. In realistic environments, actions often have uncertain outcomes and can have complex relationships with other tasks. The planner approaches problems by considering all possible actions that may be taken from any state reachable from a given, initial state, and from within the constraints of a given task hierarchy that specifies what tasks may be performed by which team member.

  12. Geogebra for Solving Problems of Physics

    NASA Astrophysics Data System (ADS)

    Kllogjeri, Pellumb; Kllogjeri, Adrian

    Today is highly speed progressing the computer-based education, which allowes educators and students to use educational programming language and e-tutors to teach and learn, to interact with one another and share together the results of their work. In this paper we will be concentrated on the use of GeoGebra programme for solving problems of physics. We have brought an example from physics of how can be used GeoGebra for finding the center of mass(centroid) of a picture(or system of polygons). After the problem is solved graphically, there is an application of finding the center of a real object(a plate)by firstly, scanning the object and secondly, by inserting its scanned picture into the drawing pad of GeoGebra window and lastly, by finding its centroid. GeoGebra serve as effective tool in problem-solving. There are many other applications of GeoGebra in the problems of physics, and many more in different fields of mathematics.

  13. Solving Nonlinear Euler Equations with Arbitrary Accuracy

    NASA Technical Reports Server (NTRS)

    Dyson, Rodger W.

    2005-01-01

    A computer program that efficiently solves the time-dependent, nonlinear Euler equations in two dimensions to an arbitrarily high order of accuracy has been developed. The program implements a modified form of a prior arbitrary- accuracy simulation algorithm that is a member of the class of algorithms known in the art as modified expansion solution approximation (MESA) schemes. Whereas millions of lines of code were needed to implement the prior MESA algorithm, it is possible to implement the present MESA algorithm by use of one or a few pages of Fortran code, the exact amount depending on the specific application. The ability to solve the Euler equations to arbitrarily high accuracy is especially beneficial in simulations of aeroacoustic effects in settings in which fully nonlinear behavior is expected - for example, at stagnation points of fan blades, where linearizing assumptions break down. At these locations, it is necessary to solve the full nonlinear Euler equations, and inasmuch as the acoustical energy is of the order of 4 to 5 orders of magnitude below that of the mean flow, it is necessary to achieve an overall fractional error of less than 10-6 in order to faithfully simulate entropy, vortical, and acoustical waves.

  14. Teaching Problem Solving Skills to Elementary Age Students with Autism

    ERIC Educational Resources Information Center

    Cote, Debra L.; Jones, Vita L.; Barnett, Crystal; Pavelek, Karin; Nguyen, Hoang; Sparks, Shannon L.

    2014-01-01

    Students with disabilities need problem-solving skills to promote their success in solving the problems of daily life. The research into problem-solving instruction has been limited for students with autism. Using a problem-solving intervention and the Self Determined Learning Model of Instruction, three elementary age students with autism were…

  15. Young Children's Analogical Problem Solving: Gaining Insights from Video Displays

    ERIC Educational Resources Information Center

    Chen, Zhe; Siegler, Robert S.

    2013-01-01

    This study examined how toddlers gain insights from source video displays and use the insights to solve analogous problems. Two- to 2.5-year-olds viewed a source video illustrating a problem-solving strategy and then attempted to solve analogous problems. Older but not younger toddlers extracted the problem-solving strategy depicted in the video…

  16. Journey into Problem Solving: A Gift from Polya

    ERIC Educational Resources Information Center

    Lederman, Eric

    2009-01-01

    In "How to Solve It", accomplished mathematician and skilled communicator George Polya describes a four-step universal solving technique designed to help students develop mathematical problem-solving skills. By providing a glimpse at the grace with which experts solve problems, Polya provides definable methods that are not exclusive to…

  17. Effects of the SOLVE Strategy on the Mathematical Problem Solving Skills of Secondary Students with Learning Disabilities

    ERIC Educational Resources Information Center

    Freeman-Green, Shaqwana M.; O'Brien, Chris; Wood, Charles L.; Hitt, Sara Beth

    2015-01-01

    This study examined the effects of explicit instruction in the SOLVE Strategy on the mathematical problem solving skills of six Grade 8 students with specific learning disabilities. The SOLVE Strategy is an explicit instruction, mnemonic-based learning strategy designed to help students in solving mathematical word problems. Using a multiple probe…

  18. Problem-Solving Appraisal and Human Adjustment: A Review of 20 Years of Research Using the Problem Solving Inventory

    ERIC Educational Resources Information Center

    Heppner, P. Paul; Witty, Thomas E.; Dixon, Wayne A.

    2004-01-01

    This article reviews and synthesizes more than 120 studies from 20 years (1982-2002) of research that has examined problem-solving appraisal as measured by the Problem Solving Inventory (PSI). The goals of the article are fourfold: (a) introduce the construct of problem-solving appraisal and the PSI within the applied problem-solving literature,…

  19. Solving a specific Thue-Mahler equation

    NASA Astrophysics Data System (ADS)

    Tzanakis, N.; de Weger, B. M. M.

    1991-10-01

    The diophantine equation {x^3} - 3x{y^2} - {y^3} = ± {3^{{n_0}}}{17^{{n_1}}}{19^{{n_2}}} is completely solved as follows. First, a large upper bound for the variables is obtained from the theory of linear forms in p-adic and real logarithms of algebraic numbers. Then this bound is reduced to a manageable size by p-adic and real computational diophantine approximation, based on the {L^3} -algorithm. Finally the complete list of solutions is found in a sieving process. The method is in principle applicable to any Thue-Mahler equation, as the authors will show in a forthcoming paper.

  20. Solving combinatorial problems: the 15-puzzle.

    PubMed

    Pizlo, Zygmunt; Li, Zheng

    2005-09-01

    We present a series of experiments in which human subjects were tested with a well-known combinatorial problem called the 15-puzzle and in different-sized variants of this puzzle. Subjects can solve these puzzles reliably by systematically building a solution path, without performing much search and without using distances among the states of the problem. The computational complexity of the underlying mental mechanisms is very low. We formulated a computational model of the underlying cognitive processes on the basis of our results. This model applied a pyramid algorithm to individual stages of each problem. The model's performance proved to be quite similar to the subjects' performance. PMID:16496727

  1. Expert Mining for Solving Social Harmony Problems

    NASA Astrophysics Data System (ADS)

    Gu, Jifa; Song, Wuqi; Zhu, Zhengxiang; Liu, Yijun

    Social harmony problems are being existed in social system, which is an open giant complex system. For solving such kind of problems the Meta-synthesis system approach proposed by Qian XS et al will be applied. In this approach the data, information, knowledge, model, experience and wisdom should be integrated and synthesized. Data mining, text mining and web mining are good techniques for using data, information and knowledge. Model mining, psychology mining and expert mining are new techniques for mining the idea, opinions, experiences and wisdom. In this paper we will introduce the expert mining, which is based on mining the experiences, knowledge and wisdom directly from experts, managers and leaders.

  2. Using worksheets to solve the Einstein equation

    NASA Astrophysics Data System (ADS)

    Moore, Thomas A.

    2016-05-01

    This article describes how one can use worksheets to guide undergraduate students through the process of finding solutions to specific cases of the Einstein equation of general relativity. The worksheets provide expressions for a metric's Christoffel symbols and Ricci tensor components for fairly general metrics. Students can use a worksheet to adapt these expressions to specific cases where symmetry or other considerations constrain the metric components' dependencies, and then use the worksheet's results to reduce the Einstein equation to a set of simpler differential equations that they can solve. This article illustrates the process for both a diagonal metric and a metric with one off-diagonal element.

  3. Optimization neural network for solving flow problems.

    PubMed

    Perfetti, R

    1995-01-01

    This paper describes a neural network for solving flow problems, which are of interest in many areas of application as in fuel, hydro, and electric power scheduling. The neural network consist of two layers: a hidden layer and an output layer. The hidden units correspond to the nodes of the flow graph. The output units represent the branch variables. The network has a linear order of complexity, it is easily programmable, and it is suited for analog very large scale integration (VLSI) realization. The functionality of the proposed network is illustrated by a simulation example concerning the maximal flow problem. PMID:18263420

  4. An approach to solving large reliability models

    NASA Technical Reports Server (NTRS)

    Boyd, Mark A.; Veeraraghavan, Malathi; Dugan, Joanne Bechta; Trivedi, Kishor S.

    1988-01-01

    This paper describes a unified approach to the problem of solving large realistic reliability models. The methodology integrates behavioral decomposition, state trunction, and efficient sparse matrix-based numerical methods. The use of fault trees, together with ancillary information regarding dependencies to automatically generate the underlying Markov model state space is proposed. The effectiveness of this approach is illustrated by modeling a state-of-the-art flight control system and a multiprocessor system. Nonexponential distributions for times to failure of components are assumed in the latter example. The modeling tool used for most of this analysis is HARP (the Hybrid Automated Reliability Predictor).

  5. Cooperative problem solving in rooks (Corvus frugilegus).

    PubMed

    Seed, Amanda M; Clayton, Nicola S; Emery, Nathan J

    2008-06-22

    Recent work has shown that captive rooks, like chimpanzees and other primates, develop cooperative alliances with their conspecifics. Furthermore, the pressures hypothesized to have favoured social intelligence in primates also apply to corvids. We tested cooperative problem-solving in rooks to compare their performance and cognition with primates. Without training, eight rooks quickly solved a problem in which two individuals had to pull both ends of a string simultaneously in order to pull in a food platform. Similar to chimpanzees and capuchin monkeys, performance was better when within-dyad tolerance levels were higher. In contrast to chimpanzees, rooks did not delay acting on the apparatus while their partner gained access to the test room. Furthermore, given a choice between an apparatus that could be operated individually over one that required the action of two individuals, four out of six individuals showed no preference. These results may indicate that cooperation in chimpanzees is underpinned by more complex cognitive processes than that in rooks. Such a difference may arise from the fact that while both chimpanzees and rooks form cooperative alliances, chimpanzees, but not rooks, live in a variable social network made up of competitive and cooperative relationships. PMID:18364318

  6. Assessing Cognitive Learning of Analytical Problem Solving

    NASA Astrophysics Data System (ADS)

    Billionniere, Elodie V.

    Introductory programming courses, also known as CS1, have a specific set of expected outcomes related to the learning of the most basic and essential computational concepts in computer science (CS). However, two of the most often heard complaints in such courses are that (1) they are divorced from the reality of application and (2) they make the learning of the basic concepts tedious. The concepts introduced in CS1 courses are highly abstract and not easily comprehensible. In general, the difficulty is intrinsic to the field of computing, often described as "too mathematical or too abstract." This dissertation presents a small-scale mixed method study conducted during the fall 2009 semester of CS1 courses at Arizona State University. This study explored and assessed students' comprehension of three core computational concepts---abstraction, arrays of objects, and inheritance---in both algorithm design and problem solving. Through this investigation students' profiles were categorized based on their scores and based on their mistakes categorized into instances of five computational thinking concepts: abstraction, algorithm, scalability, linguistics, and reasoning. It was shown that even though the notion of computational thinking is not explicit in the curriculum, participants possessed and/or developed this skill through the learning and application of the CS1 core concepts. Furthermore, problem-solving experiences had a direct impact on participants' knowledge skills, explanation skills, and confidence. Implications for teaching CS1 and for future research are also considered.

  7. On Spurious Numerics in Solving Reactive Equations

    NASA Technical Reports Server (NTRS)

    Kotov, D. V; Yee, H. C.; Wang, W.; Shu, C.-W.

    2013-01-01

    The objective of this study is to gain a deeper understanding of the behavior of high order shock-capturing schemes for problems with stiff source terms and discontinuities and on corresponding numerical prediction strategies. The studies by Yee et al. (2012) and Wang et al. (2012) focus only on solving the reactive system by the fractional step method using the Strang splitting (Strang 1968). It is a common practice by developers in computational physics and engineering simulations to include a cut off safeguard if densities are outside the permissible range. Here we compare the spurious behavior of the same schemes by solving the fully coupled reactive system without the Strang splitting vs. using the Strang splitting. Comparison between the two procedures and the effects of a cut off safeguard is the focus the present study. The comparison of the performance of these schemes is largely based on the degree to which each method captures the correct location of the reaction front for coarse grids. Here "coarse grids" means standard mesh density requirement for accurate simulation of typical non-reacting flows of similar problem setup. It is remarked that, in order to resolve the sharp reaction front, local refinement beyond standard mesh density is still needed.

  8. A Flipped Pedagogy for Expert Problem Solving

    NASA Astrophysics Data System (ADS)

    Pritchard, David

    The internet provides free learning opportunities for declarative (Wikipedia, YouTube) and procedural (Kahn Academy, MOOCs) knowledge, challenging colleges to provide learning at a higher cognitive level. Our ``Modeling Applied to Problem Solving'' pedagogy for Newtonian Mechanics imparts strategic knowledge - how to systematically determine which concepts to apply and why. Declarative and procedural knowledge is learned online before class via an e-text, checkpoint questions, and homework on edX.org (see http://relate.mit.edu/physicscourse); it is organized into five Core Models. Instructors then coach students on simple ``touchstone problems'', novel exercises, and multi-concept problems - meanwhile exercising three of the four C's: communication, collaboration, critical thinking and problem solving. Students showed 1.2 standard deviations improvement on the MIT final exam after three weeks instruction, a significant positive shift in 7 of the 9 categories in the CLASS, and their grades improved by 0.5 standard deviation in their following physics course (Electricity and Magnetism).

  9. Solving the hard problem of Bertrand's paradox

    SciTech Connect

    Aerts, Diederik; Sassoli de Bianchi, Massimiliano

    2014-08-15

    Bertrand's paradox is a famous problem of probability theory, pointing to a possible inconsistency in Laplace's principle of insufficient reason. In this article, we show that Bertrand's paradox contains two different problems: an “easy” problem and a “hard” problem. The easy problem can be solved by formulating Bertrand's question in sufficiently precise terms, so allowing for a non-ambiguous modelization of the entity subjected to the randomization. We then show that once the easy problem is settled, also the hard problem becomes solvable, provided Laplace's principle of insufficient reason is applied not to the outcomes of the experiment, but to the different possible “ways of selecting” an interaction between the entity under investigation and that producing the randomization. This consists in evaluating a huge average over all possible “ways of selecting” an interaction, which we call a universal average. Following a strategy similar to that used in the definition of the Wiener measure, we calculate such universal average and therefore solve the hard problem of Bertrand's paradox. The link between Bertrand's problem of probability theory and the measurement problem of quantum mechanics is also briefly discussed.

  10. Functional reasoning in diagnostic problem solving

    NASA Technical Reports Server (NTRS)

    Sticklen, Jon; Bond, W. E.; Stclair, D. C.

    1988-01-01

    This work is one facet of an integrated approach to diagnostic problem solving for aircraft and space systems currently under development. The authors are applying a method of modeling and reasoning about deep knowledge based on a functional viewpoint. The approach recognizes a level of device understanding which is intermediate between a compiled level of typical Expert Systems, and a deep level at which large-scale device behavior is derived from known properties of device structure and component behavior. At this intermediate functional level, a device is modeled in three steps. First, a component decomposition of the device is defined. Second, the functionality of each device/subdevice is abstractly identified. Third, the state sequences which implement each function are specified. Given a functional representation and a set of initial conditions, the functional reasoner acts as a consequence finder. The output of the consequence finder can be utilized in diagnostic problem solving. The paper also discussed ways in which this functional approach may find application in the aerospace field.

  11. Comprehension and computation in Bayesian problem solving

    PubMed Central

    Johnson, Eric D.; Tubau, Elisabet

    2015-01-01

    Humans have long been characterized as poor probabilistic reasoners when presented with explicit numerical information. Bayesian word problems provide a well-known example of this, where even highly educated and cognitively skilled individuals fail to adhere to mathematical norms. It is widely agreed that natural frequencies can facilitate Bayesian inferences relative to normalized formats (e.g., probabilities, percentages), both by clarifying logical set-subset relations and by simplifying numerical calculations. Nevertheless, between-study performance on “transparent” Bayesian problems varies widely, and generally remains rather unimpressive. We suggest there has been an over-focus on this representational facilitator (i.e., transparent problem structures) at the expense of the specific logical and numerical processing requirements and the corresponding individual abilities and skills necessary for providing Bayesian-like output given specific verbal and numerical input. We further suggest that understanding this task-individual pair could benefit from considerations from the literature on mathematical cognition, which emphasizes text comprehension and problem solving, along with contributions of online executive working memory, metacognitive regulation, and relevant stored knowledge and skills. We conclude by offering avenues for future research aimed at identifying the stages in problem solving at which correct vs. incorrect reasoners depart, and how individual differences might influence this time point. PMID:26283976

  12. Solving the Swath Segment Selection Problem

    NASA Technical Reports Server (NTRS)

    Knight, Russell; Smith, Benjamin

    2006-01-01

    Several artificial-intelligence search techniques have been tested as means of solving the swath segment selection problem (SSSP) -- a real-world problem that is not only of interest in its own right, but is also useful as a test bed for search techniques in general. In simplest terms, the SSSP is the problem of scheduling the observation times of an airborne or spaceborne synthetic-aperture radar (SAR) system to effect the maximum coverage of a specified area (denoted the target), given a schedule of downlinks (opportunities for radio transmission of SAR scan data to a ground station), given the limit on the quantity of SAR scan data that can be stored in an onboard memory between downlink opportunities, and given the limit on the achievable downlink data rate. The SSSP is NP complete (short for "nondeterministic polynomial time complete" -- characteristic of a class of intractable problems that can be solved only by use of computers capable of making guesses and then checking the guesses in polynomial time).

  13. Solving optimization problems on computational grids.

    SciTech Connect

    Wright, S. J.; Mathematics and Computer Science

    2001-05-01

    Multiprocessor computing platforms, which have become more and more widely available since the mid-1980s, are now heavily used by organizations that need to solve very demanding computational problems. Parallel computing is now central to the culture of many research communities. Novel parallel approaches were developed for global optimization, network optimization, and direct-search methods for nonlinear optimization. Activity was particularly widespread in parallel branch-and-bound approaches for various problems in combinatorial and network optimization. As the cost of personal computers and low-end workstations has continued to fall, while the speed and capacity of processors and networks have increased dramatically, 'cluster' platforms have become popular in many settings. A somewhat different type of parallel computing platform know as a computational grid (alternatively, metacomputer) has arisen in comparatively recent times. Broadly speaking, this term refers not to a multiprocessor with identical processing nodes but rather to a heterogeneous collection of devices that are widely distributed, possibly around the globe. The advantage of such platforms is obvious: they have the potential to deliver enormous computing power. Just as obviously, however, the complexity of grids makes them very difficult to use. The Condor team, headed by Miron Livny at the University of Wisconsin, were among the pioneers in providing infrastructure for grid computations. More recently, the Globus project has developed technologies to support computations on geographically distributed platforms consisting of high-end computers, storage and visualization devices, and other scientific instruments. In 1997, we started the metaneos project as a collaborative effort between optimization specialists and the Condor and Globus groups. Our aim was to address complex, difficult optimization problems in several areas, designing and implementing the algorithms and the software

  14. Modeling Regular Replacement for String Constraint Solving

    NASA Technical Reports Server (NTRS)

    Fu, Xiang; Li, Chung-Chih

    2010-01-01

    Bugs in user input sanitation of software systems often lead to vulnerabilities. Among them many are caused by improper use of regular replacement. This paper presents a precise modeling of various semantics of regular substitution, such as the declarative, finite, greedy, and reluctant, using finite state transducers (FST). By projecting an FST to its input/output tapes, we are able to solve atomic string constraints, which can be applied to both the forward and backward image computation in model checking and symbolic execution of text processing programs. We report several interesting discoveries, e.g., certain fragments of the general problem can be handled using less expressive deterministic FST. A compact representation of FST is implemented in SUSHI, a string constraint solver. It is applied to detecting vulnerabilities in web applications

  15. Exploiting Quantum Resonance to Solve Combinatorial Problems

    NASA Technical Reports Server (NTRS)

    Zak, Michail; Fijany, Amir

    2006-01-01

    Quantum resonance would be exploited in a proposed quantum-computing approach to the solution of combinatorial optimization problems. In quantum computing in general, one takes advantage of the fact that an algorithm cannot be decoupled from the physical effects available to implement it. Prior approaches to quantum computing have involved exploitation of only a subset of known quantum physical effects, notably including parallelism and entanglement, but not including resonance. In the proposed approach, one would utilize the combinatorial properties of tensor-product decomposability of unitary evolution of many-particle quantum systems for physically simulating solutions to NP-complete problems (a class of problems that are intractable with respect to classical methods of computation). In this approach, reinforcement and selection of a desired solution would be executed by means of quantum resonance. Classes of NP-complete problems that are important in practice and could be solved by the proposed approach include planning, scheduling, search, and optimal design.

  16. Scientific problem solving by expert systems

    NASA Astrophysics Data System (ADS)

    Good, Ron

    Human expert problem solving in science is defined and used to account for scientific discovery. These ideas, attributed largely to Herbert Simon, are used in a description of BACON.5, a machine expert problem solver that discovers scientific laws using data-driven heuristics and expectations such as symmetry. Trial-and-error search of data-driven scientific discovery is drastically reduced when the BACON.5 system is altered to include expectations, such as symmetry, which have been influential in real (i.e., human) discoveries of scientific laws. A discussion of the implications of BACON.5-type research for traditional science education research recognizes the importance of a qualitative understanding of the relationships among pieces of a physical or biological system.

  17. Solving Partial Differential Equations on Overlapping Grids

    SciTech Connect

    Henshaw, W D

    2008-09-22

    We discuss the solution of partial differential equations (PDEs) on overlapping grids. This is a powerful technique for efficiently solving problems in complex, possibly moving, geometry. An overlapping grid consists of a set of structured grids that overlap and cover the computational domain. By allowing the grids to overlap, grids for complex geometries can be more easily constructed. The overlapping grid approach can also be used to remove coordinate singularities by, for example, covering a sphere with two or more patches. We describe the application of the overlapping grid approach to a variety of different problems. These include the solution of incompressible fluid flows with moving and deforming geometry, the solution of high-speed compressible reactive flow with rigid bodies using adaptive mesh refinement (AMR), and the solution of the time-domain Maxwell's equations of electromagnetism.

  18. Solving large sparse eigenvalue problems on supercomputers

    NASA Technical Reports Server (NTRS)

    Philippe, Bernard; Saad, Youcef

    1988-01-01

    An important problem in scientific computing consists in finding a few eigenvalues and corresponding eigenvectors of a very large and sparse matrix. The most popular methods to solve these problems are based on projection techniques on appropriate subspaces. The main attraction of these methods is that they only require the use of the matrix in the form of matrix by vector multiplications. The implementations on supercomputers of two such methods for symmetric matrices, namely Lanczos' method and Davidson's method are compared. Since one of the most important operations in these two methods is the multiplication of vectors by the sparse matrix, methods of performing this operation efficiently are discussed. The advantages and the disadvantages of each method are compared and implementation aspects are discussed. Numerical experiments on a one processor CRAY 2 and CRAY X-MP are reported. Possible parallel implementations are also discussed.

  19. A connectionist model for diagnostic problem solving

    NASA Technical Reports Server (NTRS)

    Peng, Yun; Reggia, James A.

    1989-01-01

    A competition-based connectionist model for solving diagnostic problems is described. The problems considered are computationally difficult in that (1) multiple disorders may occur simultaneously and (2) a global optimum in the space exponential to the total number of possible disorders is sought as a solution. The diagnostic problem is treated as a nonlinear optimization problem, and global optimization criteria are decomposed into local criteria governing node activation updating in the connectionist model. Nodes representing disorders compete with each other to account for each individual manifestation, yet complement each other to account for all manifestations through parallel node interactions. When equilibrium is reached, the network settles into a locally optimal state. Three randomly generated examples of diagnostic problems, each of which has 1024 cases, were tested, and the decomposition plus competition plus resettling approach yielded very high accuracy.

  20. Solving multi-leader-common-follower games.

    SciTech Connect

    Leyffer, S.; Munson, T.; Mathematics and Computer Science

    2010-01-01

    Multi-leader-common-follower games arise when modelling two or more competitive firms, the leaders, that commit to their decisions prior to another group of competitive firms, the followers, that react to the decisions made by the leaders. These problems lead in a natural way to equilibrium problems with equilibrium constraints (EPECs). We develop a characterization of the solution sets for these problems and examine a variety of nonlinear optimization and nonlinear complementarity formulations of EPECs. We distinguish two broad cases: problems where the leaders can cost-differentiate and problems with price-consistent followers. We demonstrate the practical viability of our approach by solving a range of medium-sized test problems.

  1. Glycoprotein Structural Genomics: Solving the Glycosylation Problem

    PubMed Central

    Chang, Veronica T.; Crispin, Max; Aricescu, A. Radu; Harvey, David J.; Nettleship, Joanne E.; Fennelly, Janet A.; Yu, Chao; Boles, Kent S.; Evans, Edward J.; Stuart, David I.; Dwek, Raymond A.; Jones, E. Yvonne; Owens, Raymond J.; Davis, Simon J.

    2007-01-01

    Summary Glycoproteins present special problems for structural genomic analysis because they often require glycosylation in order to fold correctly, whereas their chemical and conformational heterogeneity generally inhibits crystallization. We show that the “glycosylation problem” can be solved by expressing glycoproteins transiently in mammalian cells in the presence of the N-glycosylation processing inhibitors, kifunensine or swainsonine. This allows the correct folding of the glycoproteins, but leaves them sensitive to enzymes, such as endoglycosidase H, that reduce the N-glycans to single residues, enhancing crystallization. Since the scalability of transient mammalian expression is now comparable to that of bacterial systems, this approach should relieve one of the major bottlenecks in structural genomic analysis. PMID:17355862

  2. Incubation and Intuition in Creative Problem Solving

    PubMed Central

    Gilhooly, Kenneth J.

    2016-01-01

    Creative problem solving, in which novel solutions are required, has often been seen as involving a special role for unconscious processes (Unconscious Work) which can lead to sudden intuitive solutions (insights) when a problem is set aside during incubation periods. This notion of Unconscious Work during incubation periods is supported by a review of experimental studies and particularly by studies using the Immediate Incubation paradigm. Other explanations for incubation effects, in terms of Intermittent Work or Beneficial Forgetting are considered. Some recent studies of divergent thinking, using the Alternative Uses task, carried out in my laboratory regarding Immediate vs. Delayed Incubation and the effects of resource competition from interpolated activities are discussed. These studies supported a role for Unconscious Work as against Intermittent Conscious work or Beneficial Forgetting in incubation. PMID:27499745

  3. Incubation and Intuition in Creative Problem Solving.

    PubMed

    Gilhooly, Kenneth J

    2016-01-01

    Creative problem solving, in which novel solutions are required, has often been seen as involving a special role for unconscious processes (Unconscious Work) which can lead to sudden intuitive solutions (insights) when a problem is set aside during incubation periods. This notion of Unconscious Work during incubation periods is supported by a review of experimental studies and particularly by studies using the Immediate Incubation paradigm. Other explanations for incubation effects, in terms of Intermittent Work or Beneficial Forgetting are considered. Some recent studies of divergent thinking, using the Alternative Uses task, carried out in my laboratory regarding Immediate vs. Delayed Incubation and the effects of resource competition from interpolated activities are discussed. These studies supported a role for Unconscious Work as against Intermittent Conscious work or Beneficial Forgetting in incubation. PMID:27499745

  4. Raman Scattering in Carbon Nanosystems: Solving Polyacetylene

    PubMed Central

    2015-01-01

    Polyacetylene has been a paradigm conjugated organic conductor since well before other conjugated carbon systems such as nanotubes and graphene became front and center. It is widely acknowledged that Raman spectroscopy of these systems is extremely important to characterize them and understand their internal quantum behavior. Here we show, for the first time, what information the Raman spectrum of polyacetylene contains, by solving the 35-year-old mystery of its spectrum. Our methods have immediate and clear implications for other conjugated carbon systems. By relaxing the nearly universal approximation of ignoring the nuclear coordinate dependence of the transition moment (Condon approximation), we find the reasons for its unusual spectroscopic features. When the Kramers–Heisenberg–Dirac Raman scattering theory is fully applied, incorporating this nuclear coordinate dependence, and also the energy and momentum dependence of the electronic and phonon band structure, then unusual line shapes, growth, and dispersion of the bands are explained and very well matched by theory. PMID:27162945

  5. Dynamic discretization method for solving Kepler's equation

    NASA Astrophysics Data System (ADS)

    Feinstein, Scott A.; McLaughlin, Craig A.

    2006-09-01

    Kepler’s equation needs to be solved many times for a variety of problems in Celestial Mechanics. Therefore, computing the solution to Kepler’s equation in an efficient manner is of great importance to that community. There are some historical and many modern methods that address this problem. Of the methods known to the authors, Fukushima’s discretization technique performs the best. By taking more of a system approach and combining the use of discretization with the standard computer science technique known as dynamic programming, we were able to achieve even better performance than Fukushima. We begin by defining Kepler’s equation for the elliptical case and describe existing solution methods. We then present our dynamic discretization method and show the results of a comparative analysis. This analysis will demonstrate that, for the conditions of our tests, dynamic discretization performs the best.

  6. Solving stochastic epidemiological models using computer algebra

    NASA Astrophysics Data System (ADS)

    Hincapie, Doracelly; Ospina, Juan

    2011-06-01

    Mathematical modeling in Epidemiology is an important tool to understand the ways under which the diseases are transmitted and controlled. The mathematical modeling can be implemented via deterministic or stochastic models. Deterministic models are based on short systems of non-linear ordinary differential equations and the stochastic models are based on very large systems of linear differential equations. Deterministic models admit complete, rigorous and automatic analysis of stability both local and global from which is possible to derive the algebraic expressions for the basic reproductive number and the corresponding epidemic thresholds using computer algebra software. Stochastic models are more difficult to treat and the analysis of their properties requires complicated considerations in statistical mathematics. In this work we propose to use computer algebra software with the aim to solve epidemic stochastic models such as the SIR model and the carrier-borne model. Specifically we use Maple to solve these stochastic models in the case of small groups and we obtain results that do not appear in standard textbooks or in the books updated on stochastic models in epidemiology. From our results we derive expressions which coincide with those obtained in the classical texts using advanced procedures in mathematical statistics. Our algorithms can be extended for other stochastic models in epidemiology and this shows the power of computer algebra software not only for analysis of deterministic models but also for the analysis of stochastic models. We also perform numerical simulations with our algebraic results and we made estimations for the basic parameters as the basic reproductive rate and the stochastic threshold theorem. We claim that our algorithms and results are important tools to control the diseases in a globalized world.

  7. Solving Math Problems Approximately: A Developmental Perspective

    PubMed Central

    Ganor-Stern, Dana

    2016-01-01

    Although solving arithmetic problems approximately is an important skill in everyday life, little is known about the development of this skill. Past research has shown that when children are asked to solve multi-digit multiplication problems approximately, they provide estimates that are often very far from the exact answer. This is unfortunate as computation estimation is needed in many circumstances in daily life. The present study examined 4th graders, 6th graders and adults’ ability to estimate the results of arithmetic problems relative to a reference number. A developmental pattern was observed in accuracy, speed and strategy use. With age there was a general increase in speed, and an increase in accuracy mainly for trials in which the reference number was close to the exact answer. The children tended to use the sense of magnitude strategy, which does not involve any calculation but relies mainly on an intuitive coarse sense of magnitude, while the adults used the approximated calculation strategy which involves rounding and multiplication procedures, and relies to a greater extent on calculation skills and working memory resources. Importantly, the children were less accurate than the adults, but were well above chance level. In all age groups performance was enhanced when the reference number was smaller (vs. larger) than the exact answer and when it was far (vs. close) from it, suggesting the involvement of an approximate number system. The results suggest the existence of an intuitive sense of magnitude for the results of arithmetic problems that might help children and even adults with difficulties in math. The present findings are discussed in the context of past research reporting poor estimation skills among children, and the conditions that might allow using children estimation skills in an effective manner. PMID:27171224

  8. The Effect of a Problem-Solving Teaching Method on Student Problem-Solving Processes.

    ERIC Educational Resources Information Center

    Frank, David V.; Herron, J. Dudley

    A problem-solving method of teaching was used in the recitation sections of a freshmen chemistry course for science and engineering majors at Purdue University. The method was based on prior research which revealed that good problem solvers formed better representations and used heuristics more often than poor problem solvers. Consequently, the…

  9. A Process Analysis of Engineering Problem Solving and Assessment of Problem Solving Skills

    ERIC Educational Resources Information Center

    Grigg, Sarah J.

    2012-01-01

    In the engineering profession, one of the most critical skills to possess is accurate and efficient problem solving. Thus, engineering educators should strive to help students develop skills needed to become competent problem solvers. In order to measure the development of skills, it is necessary to assess student performance, identify any…

  10. Effectiveness of Word Solving: Integrating Morphological Problem-Solving within Comprehension Instruction for Middle School Students

    ERIC Educational Resources Information Center

    Goodwin, Amanda P.

    2016-01-01

    This study explores the effectiveness of integrating morphological instruction within comprehension strategy instruction. Participants were 203 students (N = 117 fifth-grade; 86 sixth-grade) from four urban schools who were randomly assigned to the intervention (N = 110; morphological problem-solving within comprehension strategy instruction) or…

  11. "I'm Not Very Good at Solving Problems": An Exploration of Students' Problem Solving Behaviours

    ERIC Educational Resources Information Center

    Muir, Tracey; Beswick, Kim; Williamson, John

    2008-01-01

    This paper reports one aspect of a larger study which looked at the strategies used by a selection of grade 6 students to solve six non-routine mathematical problems. The data revealed that the students exhibited many of the behaviours identified in the literature as being associated with novice and expert problem solvers. However, the categories…

  12. The Impact of Student Thinking Journals and Generic Problem Solving Software on Problem Solving Performance.

    ERIC Educational Resources Information Center

    Sullivan, Gary E.

    This study examined the effects of specially designed thinking journal activities that have been attributed with encouraging reflective thinking, on instruction using generic, or content-free, problem solving software. Sixty-three fourth grade students participated in four instructional sessions using the software package called "Moptown Hotel."…

  13. Experimenting with Classroom Formats To Encourage Problem Solving.

    ERIC Educational Resources Information Center

    Fernandez, Eileen; Kazimir, Jessica; Vandemeulebroeke, Lynn; Burgos, Carlos

    2002-01-01

    Describes how modifying familiar classroom formats in a college geometry class helped encourage student problem solving. Demonstrates these modified formats in the context of problems students explored, which resemble the problem-solving settings of mathematicians. (KHR)

  14. Promoting Problem Solving across Geometry and Algebra by Using Technology

    ERIC Educational Resources Information Center

    Erbas, A. Kursat; Ledford, Sara D.; Orrill, Chandra Hawley; Polly, Drew

    2005-01-01

    Technology is a powerful tool in assisting students in problem solving by allowing for multiple representations. The vignette offered in this article provides insight into ways to solve open-ended problems using multiple technologies.

  15. Academic Achievement, Situational Stress, and Problem-Solving Flexibility

    ERIC Educational Resources Information Center

    Rollins, Boyd C.; Calder, Colleen

    1975-01-01

    Tested two hypotheses: (1) academic underachievers will have less problem solving flexibility during failure than during success; and (2) academic overachievers will have more problem solving flexibility during failure than during success. Subjects were tenth grade boys. (Author/SDH)

  16. Journey into Problem Solving: A Gift from Polya

    NASA Astrophysics Data System (ADS)

    Lederman, Eric

    2009-02-01

    In How to Solve It, accomplished mathematician and skilled communicator George Polya describes a four-step universal solving technique designed to help students develop mathematical problem-solving skills. By providing a glimpse at the grace with which experts solve problems, Polya provides definable methods that are not exclusive to mathematicians but of interest to cognitive psychologists and problem solvers in all fields. I had the good fortune to be introduced to Polya's ideas in my first undergraduate class in physics.

  17. Problem Solving in the School Curriculum from a Design Perspective

    ERIC Educational Resources Information Center

    Toh, Tin Lam; Leong, Yew Hoong; Dindyal, Jaguthsing; Quek, Khiok Seng

    2010-01-01

    In this symposium, the participants discuss some preliminary data collected from their problem solving project which uses a design experiment approach. Their approach to problem solving in the school curriculum is in tandem with what Schoenfeld (2007) claimed: "Crafting instruction that would make a wide range of problem-solving strategies…

  18. Teacher Practices with Toddlers during Social Problem Solving Opportunities

    ERIC Educational Resources Information Center

    Gloeckler, Lissy; Cassell, Jennifer

    2012-01-01

    This article explores how teachers can foster an environment that facilitates social problem solving when toddlers experience conflict, emotional dysregulation, and aggression. This article examines differences in child development and self-regulation outcomes when teachers engage in problem solving "for" toddlers and problem solving "with"…

  19. Solving Complex Problems: A Convergent Approach to Cognitive Load Measurement

    ERIC Educational Resources Information Center

    Zheng, Robert; Cook, Anne

    2012-01-01

    The study challenged the current practices in cognitive load measurement involving complex problem solving by manipulating the presence of pictures in multiple rule-based problem-solving situations and examining the cognitive load resulting from both off-line and online measures associated with complex problem solving. Forty-eight participants…

  20. The Authentic Performance-Based Assessment of Problem Solving.

    ERIC Educational Resources Information Center

    Curtis, David; Denton, Rob

    A new authentic performance-based approach to assessing problem solving was developed for use in vocational education and other programs in Australia. The process of developing the problem-solving assessment instrument and process included the following phases: (1) exploration of the theoretical conceptions of problem solving; (2) identification…

  1. Conflict Management: A Premarital Training Program in Mutual Problem Solving.

    ERIC Educational Resources Information Center

    Ridley, Carl A.; And Others

    1981-01-01

    Evaluated the effectiveness of a structured educational program to train premarital couples in communication and mutual problem-solving skills. Couples (N=26) participated in a problem-solving training program, while similar couples (N=28) participated in a relationship discussion group. The problem-solving group showed a greater increase in…

  2. Maximum/Minimum Problems Solved Using an Algebraic Way

    ERIC Educational Resources Information Center

    Modica, Erasmo

    2010-01-01

    This article describes some problems of the maximum/minimum type, which are generally solved using calculus at secondary school, but which here are solved algebraically. We prove six algebraic properties and then apply them to this kind of problem. This didactic approach allows pupils to solve these problems even at the beginning of secondary…

  3. Surveying Graduate Students' Attitudes and Approaches to Problem Solving

    ERIC Educational Resources Information Center

    Mason, Andrew; Singh, Chandralekha

    2010-01-01

    Students' attitudes and approaches to problem solving in physics can profoundly influence their motivation to learn and development of expertise. We developed and validated an Attitudes and Approaches to Problem Solving survey by expanding the Attitudes toward Problem Solving survey of Marx and Cummings and administered it to physics graduate…

  4. Teaching Problem Solving in Secondary School Mathematics Classrooms

    ERIC Educational Resources Information Center

    Lam, Toh Tin; Guan, Tay Eng; Seng, Quek Khiok; Hoong, Leong Yew; Choon, Toh Pee; Him, Ho Foo; Jaguthsing, Dindyal

    2014-01-01

    This paper reports an innovative approach to teaching problem solving in secondary school mathematics classrooms based on a specifically designed problem-solving module.This approach adopts the science practical paradigm and rides on the works of Polya and Schoenfeld in order to give greater emphasis to the problem solving processes. We report the…

  5. The Influence of Cognitive Diversity on Group Problem Solving Strategy

    ERIC Educational Resources Information Center

    Lamm, Alexa J.; Shoulders, Catherine; Roberts, T. Grady; Irani, Tracy A.; Snyder, Lori J. Unruh; Brendemuhl, Joel

    2012-01-01

    Collaborative group problem solving allows students to wrestle with different interpretations and solutions brought forth by group members, enhancing both critical thinking and problem solving skills. Since problem solving in groups is a common practice in agricultural education, instructors are often put in the position of organizing student…

  6. Problem Solving Interventions: Impact on Young Children with Developmental Disabilities

    ERIC Educational Resources Information Center

    Diamond, Lindsay Lile

    2012-01-01

    Problem-solving skills are imperative to a child's growth and success across multiple environments, including general and special education. Problem solving is comprised of: (a) attention to the critical aspects of a problem, (b) generation of solution(s) to solve the problem, (c) application of a solution(s) to the identified problem, and…

  7. Team-Based Complex Problem Solving: A Collective Cognition Perspective

    ERIC Educational Resources Information Center

    Hung, Woei

    2013-01-01

    Today, much problem solving is performed by teams, rather than individuals. The complexity of these problems has exceeded the cognitive capacity of any individual and requires a team of members to solve them. The success of solving these complex problems not only relies on individual team members who possess different but complementary expertise,…

  8. Problem Solving and Chemical Equilibrium: Successful versus Unsuccessful Performance.

    ERIC Educational Resources Information Center

    Camacho, Moises; Good, Ron

    1989-01-01

    Describes the problem-solving behaviors of experts and novices engaged in solving seven chemical equilibrium problems. Lists 27 behavioral tendencies of successful and unsuccessful problem solvers. Discusses several implications for a problem solving theory, think-aloud techniques, adequacy of the chemistry domain, and chemistry instruction.…

  9. A TAPS Interactive Multimedia Package to Solve Engineering Dynamics Problem

    ERIC Educational Resources Information Center

    Sidhu, S. Manjit; Selvanathan, N.

    2005-01-01

    Purpose: To expose engineering students to using modern technologies, such as multimedia packages, to learn, visualize and solve engineering problems, such as in mechanics dynamics. Design/methodology/approach: A multimedia problem-solving prototype package is developed to help students solve an engineering problem in a step-by-step approach. A…

  10. Interpersonal and Emotional Problem Solving among Narcotic Drug Abusers.

    ERIC Educational Resources Information Center

    Appel, Philip W.; Kaestner, Elisabeth

    1979-01-01

    Measured problem-solving abilities of narcotics abusers using the modified means-ends problem-solving procedure. Good subjects had more total relevent means (RMs) for solving problems, used more introspective and emotional RMs, and were better at RM recognition, but did not have more sufficient narratives than poor subjects. (Author/BEF)

  11. Perceived Problem Solving, Stress, and Health among College Students

    ERIC Educational Resources Information Center

    Largo-Wight, Erin; Peterson, P. Michael; Chen, W. William

    2005-01-01

    Objective: To study the relationships among perceived problem solving, stress, and physical health. Methods: The Perceived Stress Questionnaire (PSQ), Personal Problem solving Inventory (PSI), and a stress-related physical health symptoms checklist were used to measure perceived stress, problem solving, and health among undergraduate college…

  12. Problem Solving Strategies for Pharmaceutical/Chemical Technology College Students.

    ERIC Educational Resources Information Center

    Grant, George F.; Alexander, William E.

    Teaching problem solving strategies and steps to first year college students enrolled in the pharmaceutical/chemical technology program as a part of their first year chemistry course focused on teaching the students the basic steps in problem solving and encouraging them to plan carefully and focus on the problem solving process rather than to…

  13. Uncertainty during the Early Stages of Problem Solving

    ERIC Educational Resources Information Center

    de Hoyos, Maria; Gray, Eddie; Simpson, Adrian

    2004-01-01

    This paper discusses the role of uncertainty during the early stages of problem solving. It is argued that students start the problem solving activity with some degree of uncertainty that may vary from high to low. This degree of uncertainty may affect students' decisions at early stages of the problem solving process. It may be suggested that an…

  14. Teaching Young Children Interpersonal Problem-Solving Skills

    ERIC Educational Resources Information Center

    Joseph, Gail E.; Strain, Phillip S.

    2010-01-01

    Learning how to problem solve is one of the key developmental milestones in early childhood. Children's problem-solving skills represent a key feature in the development of social competence. Problem solving allows children to stay calm during difficult situations, repair social relations quickly, and get their needs met in ways that are safe and…

  15. Development of a Content Coding System for Marital Problem Solving.

    ERIC Educational Resources Information Center

    Winemiller, David R.; Mitchell, M. Ellen

    While much research has focused on the processes of marital problem solving, the content of marital problem solving has received considerably less attention. This study examined the initial efforts to develop a method for assessing marital problem solving content. Married individuals (N=36) completed a demographic information sheet, the Dyadic…

  16. A Decision Support System for Solving Multiple Criteria Optimization Problems

    ERIC Educational Resources Information Center

    Filatovas, Ernestas; Kurasova, Olga

    2011-01-01

    In this paper, multiple criteria optimization has been investigated. A new decision support system (DSS) has been developed for interactive solving of multiple criteria optimization problems (MOPs). The weighted-sum (WS) approach is implemented to solve the MOPs. The MOPs are solved by selecting different weight coefficient values for the criteria…

  17. The Influence of Cognitive Abilities on Mathematical Problem Solving Performance

    ERIC Educational Resources Information Center

    Bahar, Abdulkadir

    2013-01-01

    Problem solving has been a core theme in education for several decades. Educators and policy makers agree on the importance of the role of problem solving skills for school and real life success. A primary purpose of this study was to investigate the influence of cognitive abilities on mathematical problem solving performance of students. The…

  18. Internet Computer Coaches for Introductory Physics Problem Solving

    ERIC Educational Resources Information Center

    Xu Ryan, Qing

    2013-01-01

    The ability to solve problems in a variety of contexts is becoming increasingly important in our rapidly changing technological society. Problem-solving is a complex process that is important for everyday life and crucial for learning physics. Although there is a great deal of effort to improve student problem solving skills throughout the…

  19. Solving Word Problems Using Schemas: A Review of the Literature

    ERIC Educational Resources Information Center

    Powell, Sarah R.

    2011-01-01

    Solving word problems is a difficult task for students at-risk for or with learning disabilities (LD). One instructional approach that has emerged as a valid method for helping students at-risk for or with LD to become more proficient at word-problem solving is using schemas. A schema is a framework for solving a problem. With a schema, students…

  20. Capturing Problem-Solving Processes Using Critical Rationalism

    ERIC Educational Resources Information Center

    Chitpin, Stephanie; Simon, Marielle

    2012-01-01

    The examination of problem-solving processes continues to be a current research topic in education. Knowing how to solve problems is not only a key aspect of learning mathematics but is also at the heart of cognitive theories, linguistics, artificial intelligence, and computers sciences. Problem solving is a multistep, higher-order cognitive task…

  1. Can compactifications solve the cosmological constant problem?

    NASA Astrophysics Data System (ADS)

    Hertzberg, Mark P.; Masoumi, Ali

    2016-06-01

    Recently, there have been claims in the literature that the cosmological constant problem can be dynamically solved by specific compactifications of gravity from higher-dimensional toy models. These models have the novel feature that in the four-dimensional theory, the cosmological constant Λ is much smaller than the Planck density and in fact accumulates at Λ = 0. Here we show that while these are very interesting models, they do not properly address the real cosmological constant problem. As we explain, the real problem is not simply to obtain Λ that is small in Planck units in a toy model, but to explain why Λ is much smaller than other mass scales (and combinations of scales) in the theory. Instead, in these toy models, all other particle mass scales have been either removed or sent to zero, thus ignoring the real problem. To this end, we provide a general argument that the included moduli masses are generically of order Hubble, so sending them to zero trivially sends the cosmological constant to zero. We also show that the fundamental Planck mass is being sent to zero, and so the central problem is trivially avoided by removing high energy physics altogether. On the other hand, by including various large mass scales from particle physics with a high fundamental Planck mass, one is faced with a real problem, whose only known solution involves accidental cancellations in a landscape.

  2. Glow discharge based device for solving mazes

    SciTech Connect

    Dubinov, Alexander E. Mironenko, Maxim S.; Selemir, Victor D.; Maksimov, Artem N.; Pylayev, Nikolay A.

    2014-09-15

    A glow discharge based device for solving mazes has been designed and tested. The device consists of a gas discharge chamber and maze-transformer of radial-azimuth type. It allows changing of the maze pattern in a short period of time (within several minutes). The device has been tested with low pressure air. Once switched on, a glow discharge has been shown to find the shortest way through the maze from the very first attempt, even if there is a section with potential barrier for electrons on the way. It has been found that ionization waves (striations) can be excited in the maze along the length of the plasma channel. The dependancy of discharge voltage on the length of the optimal path through the maze has been measured. A reduction in discharge voltage with one or two potential barriers present has been found and explained. The dependency of the magnitude of discharge ignition voltage on the length of the optimal path through the maze has been measured. The reduction of the ignition voltage with the presence of one or two potential barriers has been observed and explained.

  3. Energy Landscapes and Solved Protein Folding Problems

    NASA Astrophysics Data System (ADS)

    Wolynes, Peter

    2004-03-01

    Peter G. Wolynes Center for Theoretical Biological Physics Department of Chemistry and Biochemistry and Physics University of California, San Diego La Jolla, CA 92093-0371 Fifteen years ago, how proteins folded into organized structures on the basis of their sequence was a great mystery. By characterizing the energy landscapes of proteins with tools from the statistical mechanics of disordered systems like spin glasses, a "new view' of the folding process became possible. Energy landscape theory provided an incentive to pursue heroic new experiments and to carry out difficult computer simulations addressing protein folding mechanisms. Many aspects of folding kinetics revealed by these studies can be quantitatively understood using the simple idea that the topography of the energy landscape is that of a "rugged funnel". Energy landscape theory provided a quantitative means of characterizing which amino acid sequences can rapidly fold. Algorithms based on energy landscape theory have been used to successfully design novel sequences that fold to a given structure in the laboratory. Energy landscape ideas have begun to transform the prediction of protein structure from sequence data from being an art to being a science. The success of energy landscape- based algorithms in predicting protein structure from sequence will be highlighted. While there is still much to learn about folding mechanisms and much work to do achieving universally reliable structure prediction, many parts of what used to be called "the protein folding problem" can now be considered solved.

  4. Solving the RNA polymerase I structural puzzle

    PubMed Central

    Moreno-Morcillo, María; Taylor, Nicholas M. I.; Gruene, Tim; Legrand, Pierre; Rashid, Umar J.; Ruiz, Federico M.; Steuerwald, Ulrich; Müller, Christoph W.; Fernández-Tornero, Carlos

    2014-01-01

    Knowing the structure of multi-subunit complexes is critical to understand basic cellular functions. However, when crystals of these complexes can be obtained they rarely diffract beyond 3 Å resolution, which complicates X-ray structure determination and refinement. The crystal structure of RNA polymerase I, an essential cellular machine that synthesizes the precursor of ribosomal RNA in the nucleolus of eukaryotic cells, has recently been solved. Here, the crucial steps that were undertaken to build the atomic model of this multi-subunit enzyme are reported, emphasizing how simple crystallographic experiments can be used to extract relevant biological information. In particular, this report discusses the combination of poor molecular replacement and experimental phases, the application of multi-crystal averaging and the use of anomalous scatterers as sequence markers to guide tracing and to locate the active site. The methods outlined here will likely serve as a reference for future structural determination of large complexes at low resolution. PMID:25286842

  5. Solving the puzzle of autoimmunity: critical questions

    PubMed Central

    Smilek, Dawn E.

    2015-01-01

    Despite recent advances in delineating the pathogenic mechanisms of autoimmune disease, the puzzle that reveals the true picture of these diverse immunological disorders is yet to be solved. We know that the human leukocyte antigen (HLA) loci as well as many different genetic susceptibility loci with relatively small effect sizes predispose to various autoimmune diseases and that environmental factors are involved in triggering disease. Models for mechanisms of disease become increasingly complex as relationships between components of both the adaptive and innate immune systems are untangled at the molecular level. In this article, we pose some of the important questions about autoimmunity where the answers will advance our understanding of disease pathogenesis and improve the rational design of novel therapies. How is autoimmunity triggered, and what components of the immune response drive the clinical manifestations of disease? What determines whether a genetically predisposed individual will develop an autoimmune disease? Is restoring immune tolerance the secret to finding cures for autoimmune disease? Current research efforts seek answers to these big questions. PMID:25750735

  6. Time solved susceptibility spectra of magnetic fluids

    NASA Astrophysics Data System (ADS)

    Marin, C. N.; Fannin, P. C.; Malaescu, I.

    2015-08-01

    Measurements of the frequency (f) and polarizing field (H) dependent complex magnetic susceptibility, χ(f, H)=χ‧(f, H)-iχ″(f, H) of a magnetic fluid over the frequency range 1 kHz to 2 MHz, in various polarizing fields from zero to approximately 7 kA/m are presented. The sample was a commercial magnetic fluid with magnetite particles in isopar-M. Usually, Brownian relaxation time measurements are involved in the investigation of particle agglomeration in magnetic fluids. In some situations the presence of miscellaneous particles may induce erroneous conclusions. The paper shows that over time measurements can solve the problem in giving confirmation of particle agglomeration within magnetic fluids. Measurements performed in a constant polarizing field of, H=7 kA/m, have shown that after 30 min both components of the complex magnetic susceptibility increased and the relaxation peak shifted towards higher frequencies. The phenomenon is correlated to the particle aggregation process and demonstrates that the relaxation peaks are due to the rotation of small aggregates.

  7. Unsupervised neural networks for solving Troesch's problem

    NASA Astrophysics Data System (ADS)

    Muhammad, Asif Zahoor Raja

    2014-01-01

    In this study, stochastic computational intelligence techniques are presented for the solution of Troesch's boundary value problem. The proposed stochastic solvers use the competency of a feed-forward artificial neural network for mathematical modeling of the problem in an unsupervised manner, whereas the learning of unknown parameters is made with local and global optimization methods as well as their combinations. Genetic algorithm (GA) and pattern search (PS) techniques are used as the global search methods and the interior point method (IPM) is used for an efficient local search. The combination of techniques like GA hybridized with IPM (GA-IPM) and PS hybridized with IPM (PS-IPM) are also applied to solve different forms of the equation. A comparison of the proposed results obtained from GA, PS, IPM, PS-IPM and GA-IPM has been made with the standard solutions including well known analytic techniques of the Adomian decomposition method, the variational iterational method and the homotopy perturbation method. The reliability and effectiveness of the proposed schemes, in term of accuracy and convergence, are evaluated from the results of statistical analysis based on sufficiently large independent runs.

  8. Solving the RNA polymerase I structural puzzle

    SciTech Connect

    Moreno-Morcillo, María; Taylor, Nicholas M. I.; Gruene, Tim; Legrand, Pierre; Rashid, Umar J.; Ruiz, Federico M.; Steuerwald, Ulrich; Müller, Christoph W.; Fernández-Tornero, Carlos

    2014-10-01

    Details of the RNA polymerase I crystal structure determination provide a framework for solution of the structures of other multi-subunit complexes. Simple crystallographic experiments are described to extract relevant biological information such as the location of the enzyme active site. Knowing the structure of multi-subunit complexes is critical to understand basic cellular functions. However, when crystals of these complexes can be obtained they rarely diffract beyond 3 Å resolution, which complicates X-ray structure determination and refinement. The crystal structure of RNA polymerase I, an essential cellular machine that synthesizes the precursor of ribosomal RNA in the nucleolus of eukaryotic cells, has recently been solved. Here, the crucial steps that were undertaken to build the atomic model of this multi-subunit enzyme are reported, emphasizing how simple crystallographic experiments can be used to extract relevant biological information. In particular, this report discusses the combination of poor molecular replacement and experimental phases, the application of multi-crystal averaging and the use of anomalous scatterers as sequence markers to guide tracing and to locate the active site. The methods outlined here will likely serve as a reference for future structural determination of large complexes at low resolution.

  9. The Effects of Thinking Aloud Pair Problem Solving on High School Students' Chemistry Problem-Solving Performance and Verbal Interactions

    ERIC Educational Resources Information Center

    Jeon, Kyungmoon; Huffman, Douglas; Noh, Taehee

    2005-01-01

    A problem solving strategy, Thinking Aloud Pair Problem Solving (TAPPS), developed by Arthur Whimbey to help students monitor and understand their own thought process is presented. The TAPPS strategy encouraged the students interact verbally with each other to solve chemistry problems and improve the achievements in chemistry.

  10. Effects of Training in Problem Solving on the Problem-Solving Abilities of Gifted Fourth Graders: A Comparison of the Future Problem Solving and Instrumental Enrichment Programs.

    ERIC Educational Resources Information Center

    Dufner, Hillrey A.; Alexander, Patricia A.

    The differential effects of two different types of problem-solving training on the problem-solving abilities of gifted fourth graders were studied. Two successive classes of gifted fourth graders from Weslaco Independent School District (Texas) were pretested with the Coloured Progressive Matrices (CPM) and Thinking Creatively With Pictures…

  11. The relationship between students' problem solving frames and epistemological beliefs

    NASA Astrophysics Data System (ADS)

    Wampler, Wendi N.

    Introductory undergraduate physics courses aim to help students develop the skills and strategies necessary to solve complex, real world problems, but many students not only leave these courses with serious gaps in their conceptual understanding, but also maintain a novice-like approach to solving problems. Matter and Interactions [M&I] is a curriculum that focuses on a restructuring of physics content knowledge and emphasizes a systematic approach to problem solving, called modeling, which involves the application physical principles to carefully defined systems of objects and interactions (Chabay and Sherwood, 2007a). Because the M&I approach to problem solving is different from many students' previous physics experience, efforts need to be made to attend to their epistemological beliefs and expectations about not only learning physics content knowledge, but problem solving as well. If a student frames solving physics problems as a `plug and chug' type activity, then they are going continue practicing this strategy. Thus, it is important to address students' epistemological beliefs and monitor how they frame the activity of problem solving within the M&I course. This study aims to investigate how students frame problem solving within the context of a large scale implementation of the M&I curriculum, and how, if at all, those frames shift through the semester. By investigating how students frame the act of problem solving in the M&I context, I was able to examine the connection between student beliefs and expectations about problem solving in physics and the skills and strategies used while solving problems in class. To accomplish these goals, I recruited student volunteers from Purdue's introductory, calculus-based physics course and assessed their problem solving approach and espoused epistemological beliefs over the course of a semester. I obtained data through video recordings of the students engaged in small group problem solving during recitation activities

  12. Analyzing the many skills involved in solving complex physics problems

    NASA Astrophysics Data System (ADS)

    Adams, Wendy K.; Wieman, Carl E.

    2015-05-01

    We have empirically identified over 40 distinct sub-skills that affect a person's ability to solve complex problems in many different contexts. The identification of so many sub-skills explains why it has been so difficult to teach or assess problem solving as a single skill. The existence of these sub-skills is supported by several studies comparing a wide range of individuals' strengths and weaknesses in these sub-skills, their "problem solving fingerprint," while solving different types of problems including a classical mechanics problem, quantum mechanics problems, and a complex trip-planning problem with no physics. We see clear differences in the problem solving fingerprint of physics and engineering majors compared to the elementary education majors that we tested. The implications of these findings for guiding the teaching and assessing of problem solving in physics instruction are discussed.

  13. Using Analogy to Solve a Three-Step Physics Problem

    NASA Astrophysics Data System (ADS)

    Lin, Shih-Yin; Singh, Chandralekha

    2010-10-01

    In a companion paper, we discuss students' ability to take advantage of what they learn from a solved problem and transfer their learning to solve a quiz problem that has different surface features but the same underlying physics principles. Here, we discuss students' ability to perform analogical reasoning between another pair of problems. Both the problems can be solved using the same physics principles. However, the solved problem provided was a two-step problem (which can be solved by decomposing it into two sub-problems) while the quiz problem was a three-step problem. We find that it is challenging for students to extend what they learned from a two-step problem to solve a three-step problem.

  14. Facilitating Students' Problem Solving across Multiple Representations in Introductory Mechanics

    NASA Astrophysics Data System (ADS)

    Nguyen, Dong-Hai; Gire, Elizabeth; Rebello, N. Sanjay

    2010-10-01

    Solving problems presented in multiple representations is an important skill for future physicists and engineers. However, such a task is not easy for most students taking introductory physics courses. We conducted teaching/learning interviews with 20 students in a first-semester calculus-based physics course on several topics in introductory mechanics. These interviews helped identify the common difficulties students encountered when solving physics problems posed in multiple representations as well as the hints that help students overcome those difficulties. We found that most representational difficulties arise due to the lack of students' ability to associate physics knowledge with corresponding mathematical knowledge. Based on those findings, we developed, tested and refined a set of problem-solving exercises to help students learn to solve problems in graphical and equational representations. We present our findings on students' common difficulties with graphical and equational representations, the problem-solving exercises and their impact on students' problem solving abilities.

  15. Problem solving performance and learning strategies of undergraduate students who solved microbiology problems using IMMEX educational software

    NASA Astrophysics Data System (ADS)

    Ebomoyi, Josephine Itota

    The objectives of this study were as follows: (1) Determine the relationship between learning strategies and performance in problem solving, (2) Explore the role of a student's declared major on performance in problem solving, (3) Understand the decision making process of high and low achievers during problem solving. Participants (N = 65) solved problems using the Interactive multimedia exercise (IMMEX) software. All participants not only solved "Microquest," which focuses on cellular processes and mode of action of antibiotics, but also "Creeping Crud," which focuses on the cause, origin and transmission of diseases. Participants also responded to the "Motivated Strategy Learning Questionnaire" (MSLQ). Hierarchical multiple regression was used for analysis with GPA (Gracie point average) as a control. There were 49 (78.6%) that successfully solved "Microquest" while 52 (82.5%) successfully solved "Creeping Crud". Metacognitive self regulation strategy was significantly (p < .10) related to ability to solve "Creeping Crud". Peer learning strategy showed a positive significant (p < .10) relationship with scores obtained from solving "Creeping Crud". Students' declared major made a significant (p < .05) difference on the ability to solve "Microquest". A subset (18) volunteered for a think aloud method to determine decision-making process. High achievers used fewer steps, and had more focused approach than low achievers. Common strategies and attributes included metacognitive skills, writing to keep track, using prior knowledge. Others included elements of frustration/confusion and self-esteem problems. The implications for educational and relevance to real life situations are discussed.

  16. Recent progress in solving A-D-E lattice models

    NASA Astrophysics Data System (ADS)

    Pearce, Paul A.

    1994-04-01

    There are many families of solvable A-D-E lattice models exhibiting order-disorder transitions. These represent many different universality classes of critical behaviour. Some A-D-E models can be solved off-criticality but most can only be solved at criticality. Here we review the methods being developed to solve these models to gain a detailed understanding of their critical behaviour.

  17. A descriptive study of cooperative problem solving introductory physics labs

    NASA Astrophysics Data System (ADS)

    Knutson, Paul Aanond

    The purpose of this study was to determine the ways in which cooperative problem solving in physics instructional laboratories influenced the students' ability to provide qualitative responses to problems. The literature shows that problem solving involves both qualitative and quantitative skills. Qualitative skills are important because those skills are the foundation for the quantitative aspects of problem solving. (Chi, et al., 1981). The literature also indicates that cooperative problem solving should enhance the students' performance. As a practical matter surveys of departments that require introductory physics classes expect their students to have general qualitative problem solving skills. The students in this study were asked to solve problem(s) before coming to a lab session and then cooperatively assess whether or not their answers were correct by conducting a laboratory activity for which they had to plan the procedure and obtain the necessary results. TA's were expected to provide instruction under a cognitive apprenticeship model. The results showed that the cooperative problem solving laboratories had almost no impact on the students' problem solving skills as measured from the start of a two hour lab session to the end of the lab session...The reason for this may have been that students did not have enough experience in the solving of different kinds of problems in the two domains of Newton's second Law and gravitation to overcome their misconceptions and become competent. Another possibility was that the TA's did not follow the cognitive apprenticeship model as consistently as might have been needed.

  18. Cognitive restructuring as an early stage in problem solving

    NASA Astrophysics Data System (ADS)

    Bodner, George M.; McMillen, Theresa L. B.

    This article examines the hypothesis that there are preliminary stages in problem solving which most chemists neglect when trying to teach their students how to solve problems in introductory chemistry courses. It is during these early stages that relevant information is disembedded from the question and the problem is restructured. Unless students can successfully complete these cognitive restructuring stages, they cannot proceed on to the more analytic stages in problem solving that have received more attention from chemists.Preliminary evidence for this hypothesis consists of linear correlations between student ability to handle disembedding and cognitive restructuring tasks in the spatial domain and their ability to solve chemistry problems.

  19. Surveying graduate students' attitudes and approaches to problem solving

    NASA Astrophysics Data System (ADS)

    Mason, Andrew; Singh, Chandralekha

    2010-07-01

    Students’ attitudes and approaches to problem solving in physics can profoundly influence their motivation to learn and development of expertise. We developed and validated an Attitudes and Approaches to Problem Solving survey by expanding the Attitudes toward Problem Solving survey of Marx and Cummings and administered it to physics graduate students. Comparison of their responses to the survey questions about problem solving in their own graduate-level courses vs problem solving in the introductory physics courses provides insight into their expertise in introductory and graduate-level physics. The physics graduate students’ responses to the survey questions were also compared with those of introductory physics and astronomy students and physics faculty. We find that, even for problem solving in introductory physics, graduate students’ responses to some survey questions are less expertlike than those of the physics faculty. Comparison of survey responses of graduate students and introductory students for problem solving in introductory physics suggests that graduate students’ responses are in general more expertlike than those of introductory students. However, survey responses suggest that graduate-level problem solving by graduate students on several measures has remarkably similar trends to introductory-level problem solving by introductory students.

  20. Using a general problem-solving strategy to promote transfer.

    PubMed

    Youssef-Shalala, Amina; Ayres, Paul; Schubert, Carina; Sweller, John

    2014-09-01

    Cognitive load theory was used to hypothesize that a general problem-solving strategy based on a make-as-many-moves-as-possible heuristic could facilitate problem solutions for transfer problems. In four experiments, school students were required to learn about a topic through practice with a general problem-solving strategy, through a conventional problem solving strategy or by studying worked examples. In Experiments 1 and 2 using junior high school students learning geometry, low knowledge students in the general problem-solving group scored significantly higher on near or far transfer tests than the conventional problem-solving group. In Experiment 3, an advantage for a general problem-solving group over a group presented worked examples was obtained on far transfer tests using the same curriculum materials, again presented to junior high school students. No differences between conditions were found in Experiments 1, 2, or 3 using test problems similar to the acquisition problems. Experiment 4 used senior high school students studying economics and found the general problem-solving group scored significantly higher than the conventional problem-solving group on both similar and transfer tests. It was concluded that the general problem-solving strategy was helpful for novices, but not for students that had access to domain-specific knowledge. PMID:25000309

  1. Innovation and problem solving: a review of common mechanisms.

    PubMed

    Griffin, Andrea S; Guez, David

    2014-11-01

    Behavioural innovations have become central to our thinking about how animals adjust to changing environments. It is now well established that animals vary in their ability to innovate, but understanding why remains a challenge. This is because innovations are rare, so studying innovation requires alternative experimental assays that create opportunities for animals to express their ability to invent new behaviours, or use pre-existing ones in new contexts. Problem solving of extractive foraging tasks has been put forward as a suitable experimental assay. We review the rapidly expanding literature on problem solving of extractive foraging tasks in order to better understand to what extent the processes underpinning problem solving, and the factors influencing problem solving, are in line with those predicted, and found, to underpin and influence innovation in the wild. Our aim is to determine whether problem solving can be used as an experimental proxy of innovation. We find that in most respects, problem solving is determined by the same underpinning mechanisms, and is influenced by the same factors, as those predicted to underpin, and to influence, innovation. We conclude that problem solving is a valid experimental assay for studying innovation, propose a conceptual model of problem solving in which motor diversity plays a more central role than has been considered to date, and provide recommendations for future research using problem solving to investigate innovation. This article is part of a Special Issue entitled: Cognition in the wild. PMID:25245306

  2. The Family as a Small Problem Solving Group

    ERIC Educational Resources Information Center

    Tallman, Irving

    1970-01-01

    Analyzes relationship between "open channels of communication" and "centralization of authority", and "cultural" variables in terms of their contributions to optimal problem solving structures and activities. (Author)

  3. Applying Lakatos' Theory to the Theory of Mathematical Problem Solving.

    ERIC Educational Resources Information Center

    Nunokawa, Kazuhiko

    1996-01-01

    The relation between Lakatos' theory and issues in mathematics education, especially mathematical problem solving, is investigated by examining Lakatos' methodology of a scientific research program. (AIM)

  4. Mystery of Cometary X-Rays Solved

    NASA Astrophysics Data System (ADS)

    2000-07-01

    On July 14, 2000 NASA's Chandra X-ray Observatory imaged Comet C/1999 S4 (LINEAR) and detected X-rays from oxygen and nitrogen ions. The details of the X-ray emission, as recorded on Chandra's Advanced CCD Imaging Spectrometer, show that they are produced by collisions of ions racing away from the Sun with gas in the comet. "This observation solves one mystery. It proves how comets produce X-rays," said Dr. Carey Lisse of the Space Telescope Science Institute (STScI) leader of a team of scientists from STScI, NASA's Goddard Space Flight Center, Max Planck Institute in Germany, Johns Hopkins University, the University of California, Berkeley, and the Harvard-Smithsonian Center for Astrophysics. "With an instrument like Chandra, we can now study the chemistry of the solar wind, and observe the X-ray glow from the atmospheres of comets as well as planets such as Venus. It may even be possible to observe other, nearby solar systems." Comets, which resemble "dirty snow balls" a few miles in diameter, were thought to be too cold for such energetic emission, so the detection of X-rays by the ROSAT observatory from comet Hyakutake in 1996 was a surprise. Several explanations were suggested, but the source of cometary X-ray emission remained a puzzle until the Chandra observation of Comet C/1999 S4 (LINEAR). Chandra's imaging spectrometer revealed a strong X-ray signal from oxygen and nitrogen ions, clinching the case for the production of X-rays due to the exchange of electrons in collisions between nitrogen and oxygen ions in the solar wind and electrically neutral elements (predominantly hydrogen) in the comets atmosphere. The Chandra observation was taken with the Advanced CCD Imaging Spectrometer (ACIS) on July 14, 2000 for a total of 2 ½ hours. The comet will be re-observed with Chandra during the weeks of July 29 - Aug 13. Comet C/1999 S4 (LINEAR) was discovered in September 1999 by the Lincoln Near Earth Asteroid Research (LINEAR) project, which is operated by the

  5. Goals and everyday problem solving: examining the link between age-related goals and problem-solving strategy use.

    PubMed

    Hoppmann, Christiane A; Coats, Abby Heckman; Blanchard-Fields, Fredda

    2008-07-01

    Qualitative interviews on family and financial problems from 332 adolescents, young, middle-aged, and older adults, demonstrated that developmentally relevant goals predicted problem-solving strategy use over and above problem domain. Four focal goals concerned autonomy, generativity, maintaining good relationships with others, and changing another person. We examined both self- and other-focused problem-solving strategies. Autonomy goals were associated with self-focused instrumental problem solving and generative goals were related to other-focused instrumental problem solving in family and financial problems. Goals of changing another person were related to other-focused instrumental problem solving in the family domain only. The match between goals and strategies, an indicator of problem-solving adaptiveness, showed that young individuals displayed the greatest match between autonomy goals and self-focused problem solving, whereas older adults showed a greater match between generative goals and other-focused problem solving. Findings speak to the importance of considering goals in investigations of age-related differences in everyday problem solving. PMID:17899456

  6. How do they solve it? An insight into the learner's approach to the mechanism of physics problem solving

    NASA Astrophysics Data System (ADS)

    Hegde, Balasubrahmanya; Meera, B. N.

    2012-06-01

    A perceived difficulty is associated with physics problem solving from a learner’s viewpoint, arising out of a multitude of reasons. In this paper, we have examined the microstructure of students’ thought processes during physics problem solving by combining the analysis of responses to multiple-choice questions and semistructured student interviews. Design of appropriate scaffoldings serves as pointers to the identification of student problem solving difficulties. An analysis of the results suggests the necessity of identification of the skill sets required for developing better problem solving abilities.

  7. ASA's Chandra Neon Discovery Solves Solar Paradox

    NASA Astrophysics Data System (ADS)

    2005-07-01

    NASA's Chandra X-ray Observatory survey of nearby sun-like stars suggests there is nearly three times more neon in the sun and local universe than previously believed. If true, this would solve a critical problem with understanding how the sun works. "We use the sun to test how well we understand stars and, to some extent, the rest of the universe," said Jeremy Drake of the Harvard-Smithsonian Center for Astrophysics in Cambridge, Mass. "But in order to understand the sun, we need to know exactly what it is made of," he added. It is not well known how much neon the sun contains. This is critical information for creating theoretical models of the sun. Neon atoms, along with carbon, oxygen and nitrogen, play an important role in how quickly energy flows from nuclear reactions in the sun's core to its edge, where it then radiates into space. Chandra X-ray Spectrum of II Pegasi Chandra X-ray Spectrum of II Pegasi The rate of this energy flow determines the location and size of a crucial stellar region called the convection zone. The zone extends from near the sun's surface inward approximately 125,000 miles. The zone is where the gas undergoes a rolling, convective motion much like the unstable air in a thunderstorm. "This turbulent gas has an extremely important job, because nearly all of the energy emitted at the surface of the sun is transported there by convection," Drake said. The accepted amount of neon in the sun has led to a paradox. The predicted location and size of the solar convection zone disagree with those deduced from solar oscillations. Solar oscillations is a technique astronomers previously relied on to probe the sun's interior. Several scientists have noted the problem could be fixed if the abundance of neon is in fact about three times larger than currently accepted. Attempts to measure the precise amount of neon in the Sun have been frustrated by a quirk of nature; neon atoms in the Sun give off no signatures in visible light. However, in a gas

  8. Using Problem-Solving Teaching: Theoretical and Philosophical Considerations.

    ERIC Educational Resources Information Center

    Osborne, Edward W.

    A rationale for the teaching of thinking and problem-solving skills is outlined, and the definition of and design for teaching such skills are discussed. Developing the ability of students to think has surfaced in recent years as one of the major purposes of American education. Problem solving has been described as a major type of thinking…

  9. Phenomenographic Study of Students' Problem Solving Approaches in Physics

    ERIC Educational Resources Information Center

    Walsh, Laura N.; Howard, Robert G.; Bowe, Brian

    2007-01-01

    This paper describes ongoing research investigating student approaches to quantitative and qualitative problem solving in physics. This empirical study was conducted using a phenomenographic approach to analyze data from individual semistructured problem solving interviews with 22 introductory college physics students. The main result of the study…

  10. Toward a Comprehensive Model of Problem-Solving.

    ERIC Educational Resources Information Center

    Pitt, Ruth B.

    Presented is a model of problem solving that incorporates elements of hypothetico-deductive reasoning in the Piagetian sense, and heuristic-algorithmic processing in the information-processing sense. It assumes that people invoke both formal reasoning strategies and learned algorithms whenever they solve problems. The proposed model integrates the…

  11. An Iterative Method for Solving Variable Coefficient ODEs

    ERIC Educational Resources Information Center

    Deeba, Elias; Yoon, Jeong-Mi; Zafiris, Vasilis

    2003-01-01

    In this classroom note, the authors present a method to solve variable coefficients ordinary differential equations of the form p(x)y([squared])(x) + q(x)y([superscript 1])(x) + r(x)y(x) = 0. They propose an iterative method as an alternate method to solve the above equation. This iterative method is accessible to an undergraduate student studying…

  12. Childhood Physical Punishment and Problem Solving in Marriage

    ERIC Educational Resources Information Center

    Cast, Alicia D.; Schweingruber, David; Berns, Nancy

    2006-01-01

    Drawing from social learning theories and symbolic interactionist understandings of social life, the authors suggest that physical punishment teaches aggressive and controlling strategies for solving the problems of living together and hinders the development of important problem-solving skills, specifically the ability to role take with others.…

  13. Dimensional Analysis and Qualitative Methods in Problem Solving

    ERIC Educational Resources Information Center

    Pescetti, D.

    2008-01-01

    The primary application of dimensional analysis (DA) is in problem solving. Typically, the problem description indicates that a physical quantity Y(the unknown) is a function f of other physical quantities A[subscript 1], ..., A[subscript n] (the data). We propose a qualitative problem-solving procedure which consists of a parallel decomposition…

  14. Concept Learning versus Problem Solving: Is There a Difference?

    ERIC Educational Resources Information Center

    Nurrenbern, Susan C.; Pickering, Miles

    1987-01-01

    Reports on a study into the relationship between a student's ability to solve problems in chemistry and his/her understanding of molecular concepts. Argues that teaching students to solve problems about chemistry is not equivalent to teaching about the nature of matter. (TW)

  15. Social Problem-Solving among Adolescents Treated for Depression

    PubMed Central

    Becker-Weidman, Emily G.; Jacobs, Rachel H.; Reinecke, Mark A.; Silva, Susan G.; March, John S.

    2009-01-01

    Studies suggest that deficits in social problem-solving may be associated with increased risk of depression and suicidality in children and adolescents. It is unclear, however, which specific dimensions of social problem-solving are related to depression and suicidality among youth. Moreover, rational problem-solving strategies and problem-solving motivation may moderate or predict change in depression and suicidality among children and adolescents receiving treatment. The effect of social problem-solving on acute treatment outcomes were explored in a randomized controlled trial of 439 clinically depressed adolescents enrolled in the Treatment for Adolescents with Depression Study (TADS). Measures included the Children's Depression Rating Scale-Revised (CDRS-R), the Suicidal Ideation Questionnaire – Grades 7-9 (SIQ-Jr), and the Social Problem Solving Inventory-Revised (SPSI-R). A random coefficients regression model was conducted to examine main and interaction effects of treatment and SPSI-R subscale scores on outcomes during the 12-week acute treatment stage. Negative problem orientation, positive problem orientation, and avoidant problem-solving style were non-specific predictors of depression severity. In terms of suicidality, avoidant problem-solving style and impulsiveness/carelessness style were predictors, whereas negative problem orientation and positive problem orientation were moderators of treatment outcome. Implications of these findings, limitations, and directions for future research are discussed. PMID:19775677

  16. Relationship between Problem-Solving Style and Mathematical Literacy

    ERIC Educational Resources Information Center

    Tai, Wen-Chun; Lin, Su-Wei

    2015-01-01

    Currently, mathematics education is focused on ensuring that students can apply the knowledge and skills they learn to everyday life; students are expected to develop their problem-solving abilities to face challenges by adopting various perspectives. When faced with a problem, students may employ different methods or patterns to solve it. If this…

  17. Conceptual Learning in a Principled Design Problem Solving Environment

    ERIC Educational Resources Information Center

    Prusak, Naomi; Hershkowitz, Rina; Schwarz, Baruch B.

    2013-01-01

    To what extent can instructional design be based on principles for instilling a culture of problem solving and conceptual learning? This is the main focus of the study described in this paper, in which third grade students participated in a one-year course designed to foster problem solving and mathematical reasoning. The design relied on five…

  18. LANZ: Software solving the large sparse symmetric generalized eigenproblem

    NASA Technical Reports Server (NTRS)

    Jones, Mark T.; Patrick, Merrell L.

    1990-01-01

    A package, LANZ, for solving the large symmetric generalized eigenproblem is described. The package was tested on four different architectures: Convex 200, CRAY Y-MP, Sun-3, and Sun-4. The package uses a Lanczos' method and is based on recent research into solving the generalized eigenproblem.

  19. Problem-Solving Support for English Language Learners

    ERIC Educational Resources Information Center

    Wiest, Lynda R.

    2008-01-01

    Although word problems pose greater language demands, they also encourage more meaningful problem solving and mathematics understanding. With proper instructional support, a student-centered, investigative approach to contextualized problem solving benefits all students. This article presents a lesson built on an author-adapted version of the…

  20. Effects of Problem-Solving Strategies on Different Ability Levels.

    ERIC Educational Resources Information Center

    Nichols, Teresa M.

    To determine if differing ability levels will affect the acquisition of problem-solving skills and self-esteem as a result of participation in two approaches to teaching problem-solving skills, a study was conducted with sixth graders in a posttest-only control group experimental design. Subjects were 102 sixth graders randomly assigned to 5…

  1. A Tool for Helping Veterinary Students Learn Diagnostic Problem Solving.

    ERIC Educational Resources Information Center

    Danielson, Jared A.; Bender, Holly S.; Mills, Eric M.; Vermeer, Pamela J.; Lockee, Barbara B.

    2003-01-01

    Describes the result of implementing the Problem List Generator, a computer-based tool designed to help clinical pathology veterinary students learn diagnostic problem solving. Findings suggest that student problem solving ability improved, because students identified all relevant data before providing a solution. (MES)

  2. Cognitive Restructuring as a First Step in Problem Solving.

    ERIC Educational Resources Information Center

    Bodner, George M.; McMillen, Theresa L. B.

    Chemists have bemoaned for years their students' inability to solve problems in introductory chemistry courses. However, at least part of this inability must be attributed to the fact that chemists have historically tried to teach their students to solve problems by doing nothing more than working examples. In recent years, chemists have begun to…

  3. The Effects of Age on Perceptual Problem-Solving Strategies.

    ERIC Educational Resources Information Center

    Lee, Jo Ann; Pollack, Robert H.

    Witkin's Embedded Figures Test (EFT) was used to measure the changes with age in field dependence and problem-solving ability. Qualitative data concerning problem-solving strategies and quantitative data were collected. EFT was administered to 12 females in each of the following decades: 20s, 30s, 40s, 50s, 60s, 70s. All subjects were moderately…

  4. Solving Information-Based Problems: Evaluating Sources and Information

    ERIC Educational Resources Information Center

    Brand-Gruwel, Saskia; Stadtler, Marc

    2011-01-01

    The focus of this special section is on the processes involved when solving information-based problems. Solving these problems requires from people that they are able to define the information problem, search and select usable and reliable sources and information and synthesise information into a coherent body of knowledge. An important aspect…

  5. Solving Systems of Linear Equations by Ratio and Proportion

    ERIC Educational Resources Information Center

    Katsaras, Vasilios J.

    1978-01-01

    The author describes and gives two illustrations of a method for solving a system of two linear equations. The ratio of left members is equated to the ratio of right members, the ratio of the two variables is solved for, and the resultant ratio is substituted into an original equation. (MN)

  6. The Winning Edge: Tips for Creative Problem-Solving Teams.

    ERIC Educational Resources Information Center

    Safris, Richard

    Intended for coaches of school competitive problem-solving teams, this publication details 70 suggestions for building, motivating, and training problem-solving teams in grades 4 to 8. The tips cover a range of topics related to preparing for competition, the competition itself, and post-competition. The pre-competition suggestions include: (1)…

  7. Chaining in Problem Solving: A Critique and Reinvestigation.

    ERIC Educational Resources Information Center

    Blumberg, Phyllis

    This study investigated the question of whether young children can form response chains in problem solving. After reviewing the literature relating to chaining as a component of problem solving, the author argues that a test of chaining should be free of requirements to recall previously learned material, remember general information, or apply…

  8. Use of External Visual Representations in Probability Problem Solving

    ERIC Educational Resources Information Center

    Corter, James E.; Zahner, Doris C.

    2007-01-01

    We investigate the use of external visual representations in probability problem solving. Twenty-six students enrolled in an introductory statistics course for social sciences graduate students (post-baccalaureate) solved eight probability problems in a structured interview format. Results show that students spontaneously use self-generated…

  9. Mathematical Profiles and Problem Solving Abilities of Mathematically Promising Students

    ERIC Educational Resources Information Center

    Budak, Ibrahim

    2012-01-01

    Mathematically promising students are defined as those who have the potential to become the leaders and problem solvers of the future. The purpose of this research is to reveal what problem solving abilities mathematically promising students show in solving non-routine problems and type of profiles they present in the classroom and during problem…

  10. Assessing Creative Problem-Solving with Automated Text Grading

    ERIC Educational Resources Information Center

    Wang, Hao-Chuan; Chang, Chun-Yen; Li, Tsai-Yen

    2008-01-01

    The work aims to improve the assessment of creative problem-solving in science education by employing language technologies and computational-statistical machine learning methods to grade students' natural language responses automatically. To evaluate constructs like creative problem-solving with validity, open-ended questions that elicit…

  11. A New Approach: Computer-Assisted Problem-Solving Systems

    ERIC Educational Resources Information Center

    Gok, Tolga

    2010-01-01

    Computer-assisted problem solving systems are rapidly growing in educational use and with the advent of the Internet. These systems allow students to do their homework and solve problems online with the help of programs like Blackboard, WebAssign and LON-CAPA program etc. There are benefits and drawbacks of these systems. In this study, the…

  12. A Markov Model Analysis of Problem-Solving Progress.

    ERIC Educational Resources Information Center

    Vendlinski, Terry

    This study used a computerized simulation and problem-solving tool along with artificial neural networks (ANN) as pattern recognizers to identify the common types of strategies high school and college undergraduate chemistry students would use to solve qualitative chemistry problems. Participants were 134 high school chemistry students who used…

  13. Teaching Problem-Solving Skills to Nuclear Engineering Students

    ERIC Educational Resources Information Center

    Waller, E.; Kaye, M. H.

    2012-01-01

    Problem solving is an essential skill for nuclear engineering graduates entering the workforce. Training in qualitative and quantitative aspects of problem solving allows students to conceptualise and execute solutions to complex problems. Solutions to problems in high consequence fields of study such as nuclear engineering require rapid and…

  14. Measuring Problem Solving Skills in Plants vs. Zombies 2

    ERIC Educational Resources Information Center

    Shute, Valerie J.; Moore, Gregory R.; Wang, Lubin

    2015-01-01

    We are using stealth assessment, embedded in "Plants vs. Zombies 2," to measure middle-school students' problem solving skills. This project started by developing a problem solving competency model based on a thorough review of the literature. Next, we identified relevant in-game indicators that would provide evidence about students'…

  15. Learning from Examples versus Verbal Directions in Mathematical Problem Solving

    ERIC Educational Resources Information Center

    Lee, Hee Seung; Fincham, Jon M.; Anderson, John R.

    2015-01-01

    This event-related fMRI study investigated the differences between learning from examples and learning from verbal directions in mathematical problem solving and how these instruction types affect the activity of relevant brain regions during instruction and solution periods within problem-solving trials. We identified distinct neural signatures…

  16. Best Known Problem Solving Strategies in "High-Stakes" Assessments

    ERIC Educational Resources Information Center

    Hong, Dae S.

    2011-01-01

    In its mathematics standards, National Council of Teachers of Mathematics (NCTM) states that problem solving is an integral part of all mathematics learning and exposure to problem solving strategies should be embedded across the curriculum. Furthermore, by high school, students should be able to use, decide and invent a wide range of strategies.…

  17. Problem-Solving during Shared Reading at Kindergarten

    ERIC Educational Resources Information Center

    Gosen, Myrte N.; Berenst, Jan; de Glopper, Kees

    2015-01-01

    This paper reports on a conversation analytic study of problem-solving interactions during shared reading at three kindergartens in the Netherlands. It illustrates how teachers and pupils discuss book characters' problems that arise in the events in the picture books. A close analysis of the data demonstrates that problem-solving interactions do…

  18. Socratic Problem-Solving in the Business World

    ERIC Educational Resources Information Center

    Peterson, Evan

    2009-01-01

    Accurate and effective decision-making is one of the most essential skills necessary for organizational success. The problem-solving process provides a systematic means of effectively recognizing, analyzing, and solving a dilemma. The key element in this process is critical analysis of the situation, which can be executed by a taking a Socratic…

  19. Schema Induction in Problem Solving: A Multidimensional Analysis

    ERIC Educational Resources Information Center

    Chen, Zhe; Mo, Lei

    2004-01-01

    The present research examined the processes of schema formation in problem solving. In 4 experiments, participants experienced a series of tasks analogous to A. S. Luchins' (1942) water jar problems before attempting to solve isomorphic target problems. Juxtaposing illustrative source instances varying in procedural features along multiple…

  20. Reading-Enhanced Word Problem Solving: A Theoretical Model

    ERIC Educational Resources Information Center

    Capraro, Robert M.; Capraro, Mary Margaret; Rupley, William H.

    2012-01-01

    There is a reciprocal relationship between mathematics and reading cognition. Metacognitive training within reading-enhanced problem solving should facilitate students developing an awareness of what good readers do when reading for meaning in solving mathematical problems enabling them to apply these strategies. The constructs for each cognitive…

  1. Problem Solving: Getting to the Heart of Mathematics.

    ERIC Educational Resources Information Center

    Jarrett, Denise, Ed.

    2000-01-01

    This publication features articles that illustrate how several Northwest teachers are using problem solving to achieve rigorous and imaginative learning in their classrooms. Articles include: (1) "Open-Ended Problem Solving: Weaving a Web of Ideas" (Denise Jarrett); (2) "Teenager or Tyke, Students Learn Best by Tackling Challenging Math" (Suzie…

  2. Finite-difference methods for solving loaded parabolic equations

    NASA Astrophysics Data System (ADS)

    Abdullayev, V. M.; Aida-zade, K. R.

    2016-01-01

    Loaded partial differential equations are solved numerically. For illustrative purposes, a boundary value problem for a parabolic equation with various point loads is considered. By applying difference approximations, the problems are reduced to systems of algebraic equations of special structure, which are solved using a parametric representation involving solutions of auxiliary linear systems with tridiagonal matrices. Numerical results are presented and analyzed.

  3. Secondary 2 Students' Difficulties in Solving Non-Routine Problems

    ERIC Educational Resources Information Center

    Yeo, Kai Kow Joseph

    2009-01-01

    As part of a study on mathematical problem solving of secondary 2 (13- to 14-years old) students in Singapore, 56 Secondary two students from ten secondary schools participated in this study. The purpose of this paper is to explore difficulties faced by 56 Secondary 2 students when solving problems. These interviews were analysed using the…

  4. An Approach to Simulate Understanding Student Problem-Solving Behavior.

    ERIC Educational Resources Information Center

    Wang, Z. W.; Willoughby, T. L.

    1991-01-01

    This paper describes a method of understanding student problem-solving behavior during computer-assisted instruction using trigonometry as the example domain. Instead of attempting to model the student's process for solving problems, techniques which infer the equivalence between two adjacent steps in the student's process are used to determine…

  5. Students' Metaphors for Mathematical Problem Solving

    ERIC Educational Resources Information Center

    Yee, Sean P.

    2012-01-01

    The purpose of this study was to determine the metaphors used by students to describe mathematical problem solving. This study focused on identifying how students interpret and perceive mathematical problem solving via conceptual metaphors (Lakoff and Johnson, 2003). These perceptions and interpretations were coded and analyzed qualitatively and…

  6. Students' Use of Technological Features while Solving a Mathematics Problem

    ERIC Educational Resources Information Center

    Lee, Hollylynne Stohl; Hollebrands, Karen F.

    2006-01-01

    The design of technology tools has the potential to dramatically influence how students interact with tools, and these interactions, in turn, may influence students' mathematical problem solving. To better understand these interactions, we analyzed eighth grade students' problem solving as they used a java applet designed to specifically accompany…

  7. Monitoring Affect States during Effortful Problem Solving Activities

    ERIC Educational Resources Information Center

    D'Mello, Sidney K.; Lehman, Blair; Person, Natalie

    2010-01-01

    We explored the affective states that students experienced during effortful problem solving activities. We conducted a study where 41 students solved difficult analytical reasoning problems from the Law School Admission Test. Students viewed videos of their faces and screen captures and judged their emotions from a set of 14 states (basic…

  8. A Descriptive Study of Cooperative Problem Solving Introductory Physics Labs

    ERIC Educational Resources Information Center

    Knutson, Paul Aanond

    2011-01-01

    The purpose of this study was to determine the ways in which cooperative problem solving in physics instructional laboratories influenced the students' ability to provide qualitative responses to problems. The literature shows that problem solving involves both qualitative and quantitative skills. Qualitative skills are important because those…

  9. Improving Students' Ability To Problem Solve through Social Skills Instruction.

    ERIC Educational Resources Information Center

    Hopp, Mary Ann; Horn, Cheryl L.; McGraw, Kelleen; Meyer, Jenny

    When elementary and middle level students lack effective problem-solving skills, they may make poor behavior choices in social conflicts, contributing to a negative learning and instructional environment. This action research project evaluated the impact of using social skills instruction to improve students' ability to solve problems related to…

  10. Fostering Problem-Solving in a Virtual Environment

    ERIC Educational Resources Information Center

    Morin, Danielle; Thomas, Jennifer D. E.; Saadé, Raafat George

    2015-01-01

    This article investigates students' perceptions of the relationship between Problem-Solving and the activities and resources used in a Web-based course on the fundamentals of Information Technology at a university in Montreal, Canada. We assess for the different learning components of the course, the extent of perceived problem-solving skills…

  11. The Effects of Service Learning on Student Problem Solving

    ERIC Educational Resources Information Center

    Guo, Fangfang; Yao, Meilin; Wang, Cong; Yan, Wenfan; Zong, Xiaoli

    2016-01-01

    Previous research indicated that service learning (SL) is an effective pedagogy to improve students' problem-solving ability and increase their classroom engagement. However, studies on SL are rare in China. This study examined the effects of SL on the problem solving of Chinese undergraduate students as well as the mechanism through which it…

  12. Solving the Sailors and the Coconuts Problem via Diagrammatic Approach

    ERIC Educational Resources Information Center

    Man, Yiu-Kwong

    2010-01-01

    In this article, we discuss how to use a diagrammatic approach to solve the classic sailors and the coconuts problem. It provides us an insight on how to tackle this type of problem in a novel and intuitive way. This problem-solving approach will be found useful to mathematics teachers or lecturers involved in teaching elementary number theory,…

  13. Complex Mathematical Problem Solving by Individuals and Dyads.

    ERIC Educational Resources Information Center

    Vye, Nancy J.; Goldman, Susan R.; Voss, James F.; Hmelo, Cindy; Williams, Susan; Cognition and Technology Group at Vanderbilt University

    1997-01-01

    Describes two studies of mathematical problem solving using an episode from "The Adventures of Jasper Woodbury," a set of curriculum materials that afford complex problem-solving opportunities. Discussion focuses on characteristics of problems that make solutions difficult, kinds of reasoning that dyadic interactions support, and considerations of…

  14. Computers and Problem Solving for Sixth-Grade.

    ERIC Educational Resources Information Center

    Oughton, John M.

    1995-01-01

    Presents a curriculum unit designed for average sixth-grade students intended to engage them in problem-solving experiences and to teach them problem-solving strategies. The curriculum consists of 20 sessions in which students engage in various activities using the following software packages: The Adventures of Jasper Woodbury, Rescue at Boone's…

  15. Students' Reasoning in Mathematics Textbook Task-Solving

    ERIC Educational Resources Information Center

    Sidenvall, Johan; Lithner, Johan; Jäder, Jonas

    2015-01-01

    This study reports on an analysis of students' textbook task-solving in Swedish upper secondary school. The relation between types of mathematical reasoning required, used, and the rate of correct task solutions were studied. Rote learning and superficial reasoning were common, and 80% of all attempted tasks were correctly solved using such…

  16. Cognitive Load in Algebra: Element Interactivity in Solving Equations

    ERIC Educational Resources Information Center

    Ngu, Bing Hiong; Chung, Siu Fung; Yeung, Alexander Seeshing

    2015-01-01

    Central to equation solving is the maintenance of equivalence on both sides of the equation. However, when the process involves an interaction of multiple elements, solving an equation can impose a high cognitive load. The balance method requires operations on both sides of the equation, whereas the inverse method involves operations on one side…

  17. Exploring Parental Influences on Children's Problem-Solving Skills.

    ERIC Educational Resources Information Center

    Derrington, Taletha; And Others

    This study examined the impact of different styles of parental communication and teaching on children's problem solving, focusing on how parental teaching and communication styles affected children's performance on four problem-solving games involving deduction/categorization and planning. Thirty-two children ages 4 and 5 years and their families…

  18. Role of Multiple Representations in Physics Problem Solving

    ERIC Educational Resources Information Center

    Maries, Alexandru

    2013-01-01

    This thesis explores the role of multiple representations in introductory physics students' problem solving performance through several investigations. Representations can help students focus on the conceptual aspects of physics and play a major role in effective problem solving. Diagrammatic representations can play a particularly important role…

  19. Social Problem Solving and Aggression: The Role of Depression

    ERIC Educational Resources Information Center

    Ozdemir, Yalcin; Kuzucu, Yasar; Koruklu, Nermin

    2013-01-01

    The purpose of the present study was to examine direct and indirect relations among social problem-solving, depression, and aggression, as well as the mediating role of depression in the link between social problem-solving and aggression among Turkish youth. Data for the present study were collected from 413 adolescents. The participants' age…

  20. A Descriptive Model of Information Problem Solving while Using Internet

    ERIC Educational Resources Information Center

    Brand-Gruwel, Saskia; Wopereis, Iwan; Walraven, Amber

    2009-01-01

    This paper presents the IPS-I-model: a model that describes the process of information problem solving (IPS) in which the Internet (I) is used to search information. The IPS-I-model is based on three studies, in which students in secondary and (post) higher education were asked to solve information problems, while thinking aloud. In-depth analyses…

  1. High School Students' Use of Meiosis When Solving Genetics Problems.

    ERIC Educational Resources Information Center

    Wynne, Cynthia F.; Stewart, Jim; Passmore, Cindy

    2001-01-01

    Paints a different picture of students' reasoning with meiosis as they solved complex, computer-generated genetics problems, some of which required them to revise their understanding of meiosis in response to anomalous data. Students were able to develop a rich understanding of meiosis and can utilize that knowledge to solve genetics problems.…

  2. Facilitating Flexible Problem Solving: A Cognitive Load Perspective

    ERIC Educational Resources Information Center

    Kalyuga, Slava; Renkl, Alexander; Paas, Fred

    2010-01-01

    The development of flexible, transferable problem-solving skills is an important aim of contemporary educational systems. Since processing limitations of our mind represent a major factor influencing any meaningful learning, the acquisition of flexible problem-solving skills needs to be based on known characteristics of our cognitive architecture…

  3. The Method To Acquire the Strategic Knowledge on Problem Solving.

    ERIC Educational Resources Information Center

    Takaoka, Ryo; Okamoto, Toshio

    As a person learns, his problem solving ability improves and one reason for this is the increased acquisition of "macro-rules" which make problem solving more efficient. An intelligent computer assisted learning (ICAI) system is being developed which automatically acquires the useful knowledge from the domain experts; as experts give the learning…

  4. Peer Instruction Enhanced Meaningful Learning: Ability to Solve Novel Problems

    ERIC Educational Resources Information Center

    Cortright, Ronald N.; Collins, Heidi L.; DiCarlo, Stephen E.

    2005-01-01

    Students must be able to interpret, relate, and incorporate new information with existing knowledge and apply the new information to solve novel problems. Peer instruction is a cooperative learning technique that promotes critical thinking, problem solving, and decision-making skills. Therefore, we tested the hypothesis that peer instruction…

  5. Prospective Teachers' Problem Solving Skills and Self-Confidence Levels

    ERIC Educational Resources Information Center

    Gursen Otacioglu, Sena

    2008-01-01

    The basic objective of the research is to determine whether the education that prospective teachers in different fields receive is related to their levels of problem solving skills and self-confidence. Within the mentioned framework, the prospective teachers' problem solving and self-confidence levels have been examined under several variables.…

  6. Solving Word Problems in the Primary Grades: Addition and Subtraction.

    ERIC Educational Resources Information Center

    Feinberg, Miriam M.

    The purpose of this manual is to present a series of lessons on solving word problems, each focusing on a specific concept. The solving of story problems should be incorporated into the daily mathematics lesson so that children can maintain and increase their skills. The lessons are sequenced according to their complexity. Lessons one through…

  7. Designing Computer Software for Problem-Solving Instruction.

    ERIC Educational Resources Information Center

    Duffield, Judith A.

    1991-01-01

    Discusses factors that might influence the effectiveness of computer software designed to teach problem solving. Topics discussed include the structure of knowledge; transfer of training; computers and problem solving instruction; human-computer interactions; and types of software, including drill and practice programs, tutorials, instructional…

  8. Measuring Problem Solving with Technology: A Demonstration Study for NAEP

    ERIC Educational Resources Information Center

    Bennett, Randy Elliot; Persky, Hilary; Weiss, Andy; Jenkins, Frank

    2010-01-01

    This paper describes a study intended to demonstrate how an emerging skill, problem solving with technology, might be measured in the National Assessment of Educational Progress (NAEP). Two computer-delivered assessment scenarios were designed, one on solving science-related problems through electronic information search and the other on solving…

  9. Problem Solving/Decision Making for Social and Academic Success.

    ERIC Educational Resources Information Center

    Elias, Maurice J.; Tobias, Steven E.

    Based on the premise that systematic instruction in social decision-making and problem-solving skills is a developmental right of all children, this book provides an in-service training program for teaching a set of social decision-making and problem-solving steps that are essential for success in school, in the family, with friends, in the world…

  10. Use of the Computer in Solving Mathematics Problems.

    ERIC Educational Resources Information Center

    Brooks, Sarah

    Computer programing and problem-solving steps in mathematics are viewed to have related concepts. Some heuristics are compared with some suggestions for structured programing. The one fundamental difference between problem solving in general and when using the computer is seen as the computer solution must be finite. The computer is viewed as a…

  11. Introduction to LogoWriter and Problem Solving for Educators.

    ERIC Educational Resources Information Center

    Yoder, Sharon Burrowes; Moursund, Dave

    This book about Logo programming and problem solving is designed to introduce preservice and inservice teachers to problem solving in a Logo programming environment. Such a unit of study can be an important part of an introductory computers in education course for educators. Although Logowriter--a version of Logo--was developed by Logo Computer…

  12. Strategies, Not Solutions: Involving Students in Problem Solving.

    ERIC Educational Resources Information Center

    Von Kuster, Lee N.

    1984-01-01

    Defines problem solving, discusses the use of problems developed by students that are relevant to their own lives, presents examples of practical mathematics problems that deal with local situations, discusses fringe benefits of this type of problem solving, and addresses teachers' concern that this method consumes too much time. (MBR)

  13. Engineering students' experiences and perceptions of workplace problem solving

    NASA Astrophysics Data System (ADS)

    Pan, Rui

    In this study, I interviewed 22 engineering Co-Op students about their workplace problem solving experiences and reflections and explored: 1) Of Co-Op students who experienced workplace problem solving, what are the different ways in which students experience workplace problem solving? 2) How do students perceive a) the differences between workplace problem solving and classroom problem solving and b) in what areas are they prepared by their college education to solve workplace problems? To answer my first research question, I analyzed data through the lens of phenomenography and I conducted thematic analysis to answer my second research question. The results of this study have implications for engineering education and engineering practice. Specifically, the results reveal the different ways students experience workplace problem solving, which provide engineering educators and practicing engineers a better understanding of the nature of workplace engineering. In addition, the results indicate that there is still a gap between classroom engineering and workplace engineering. For engineering educators who aspire to prepare students to be future engineers, it is imperative to design problem solving experiences that can better prepare students with workplace competency.

  14. Problem Solving and Collaboration Using Mobile Serious Games

    ERIC Educational Resources Information Center

    Sanchez, Jaime; Olivares, Ruby

    2011-01-01

    This paper presents the results obtained with the implementation of a series of learning activities based on Mobile Serious Games (MSGs) for the development of problem solving and collaborative skills in Chilean 8th grade students. Three MSGs were developed and played by teams of four students in order to solve problems collaboratively. A…

  15. The Utilization of Problem Solving for the Disabled.

    ERIC Educational Resources Information Center

    Cardon, Phillip L.; Scott, Michael L.

    The problem-solving process has contributed greatly to the field of technology education and can be used to assist persons with disabilities. One problem-solving design that can help in working with persons with disabilities is the "Engineering for Success" design. This model groups technology education students with teachers of special education…

  16. Problem Solving in Technology Education: A Taoist Perspective.

    ERIC Educational Resources Information Center

    Flowers, Jim

    1998-01-01

    Offers a new approach to teaching problem solving in technology education that encourages students to apply problem-solving skills to improving the human condition. Suggests that technology teachers incorporate elements of a Taoist approach in teaching by viewing technology as a tool with a goal of living a harmonious life. (JOW)

  17. Toward Group Problem Solving Guidelines for 21st Century Teams

    ERIC Educational Resources Information Center

    Ranieri, Kathryn L.

    2004-01-01

    Effective problem-solving skills are critical in dealing with ambiguous and often complex issues in the present-day leaner and globally diverse organizations. Yet respected, well-established problem-solving models may be misaligned within the current work environment, particularly within a team context. Models learned from a more bureaucratic,…

  18. Problem Solving, Reasoning, and Analytical Thinking in a Classroom Environment

    ERIC Educational Resources Information Center

    Robbins, Joanne K.

    2011-01-01

    Problem solving, reasoning, and analytical thinking are defined and described as teachable repertoires. This paper describes work performed at a school serving special needs children, Morningside Academy, that has resulted in specific procedures developed over the past 15 years. These procedures include modifying "Think Aloud Pair Problem Solving"…

  19. Schoenfeld's Problem Solving Theory in a Student Controlled Learning Environment

    ERIC Educational Resources Information Center

    Harskamp, E.; Suhre, C.

    2007-01-01

    This paper evaluates the effectiveness of a student controlled computer program for high school mathematics based on instruction principles derived from Schoenfeld's theory of problem solving. The computer program allows students to choose problems and to make use of hints during different episodes of solving problems. Crucial episodes are:…

  20. Students THINK: A Framework for Improving Problem Solving

    ERIC Educational Resources Information Center

    Thomas, Kelli R.

    2006-01-01

    This article presents the results of research about students' and teachers' use of an interaction framework (THINK) to guide group communication about problem solving. Students who used the THINK framework demonstrated greater gains in problem-solving achievement than students who did not use the framework.

  1. Problem Solving through an Optimization Problem in Geometry

    ERIC Educational Resources Information Center

    Poon, Kin Keung; Wong, Hang-Chi

    2011-01-01

    This article adapts the problem-solving model developed by Polya to investigate and give an innovative approach to discuss and solve an optimization problem in geometry: the Regiomontanus Problem and its application to football. Various mathematical tools, such as calculus, inequality and the properties of circles, are used to explore and reflect…

  2. Extricating Justification Scheme Theory in Middle School Mathematical Problem Solving

    ERIC Educational Resources Information Center

    Matteson, Shirley; Capraro, Mary Margaret; Capraro, Robert M.; Lincoln, Yvonna S.

    2012-01-01

    Twenty middle grades students were interviewed to gain insights into their reasoning about problem-solving strategies using a Problem Solving Justification Scheme as our theoretical lens and the basis for our analysis. The scheme was modified from the work of Harel and Sowder (1998) making it more broadly applicable and accounting for research…

  3. Social Problem Solving and Health Behaviors of Undergraduate Students.

    ERIC Educational Resources Information Center

    Elliott, Timothy R.; And Others

    1997-01-01

    Examines the relationship of social problem solving to health behaviors as reported by 126 undergraduate students. Findings revealed significant relationships between elements of social problem solving and wellness and accident prevention behaviors, and traffic and substance risk taking. However, correlations revealed differences between men and…

  4. Connectedness Indicators and the Prediction of Problem Solving Success

    ERIC Educational Resources Information Center

    Yu-Shattuck, Sharon X.

    2009-01-01

    In this study, it was hypothesized that problem solving success is dependent upon two related but district types of mathematical knowledge, content indicators and connectedness indicators. Results did indeed display that the problem solving success of 188 undergraduate students was related to these two indicators. The correlations of content…

  5. Autobiographical Memory and Social Problem-Solving in Asperger Syndrome

    ERIC Educational Resources Information Center

    Goddard, Lorna; Howlin, Patricia; Dritschel, Barbara; Patel, Trishna

    2007-01-01

    Difficulties in social interaction are a central feature of Asperger syndrome. Effective social interaction involves the ability to solve interpersonal problems as and when they occur. Here we examined social problem-solving in a group of adults with Asperger syndrome and control group matched for age, gender and IQ. We also assessed…

  6. The Relationship between Students' Problem Solving Frames and Epistemological Beliefs

    ERIC Educational Resources Information Center

    Wampler, Wendi N.

    2013-01-01

    Introductory undergraduate physics courses aim to help students develop the skills and strategies necessary to solve complex, real world problems, but many students not only leave these courses with serious gaps in their conceptual understanding, but also maintain a novice-like approach to solving problems. "Matter and Interactions"…

  7. Behavioral flexibility and problem solving in an invasive bird

    PubMed Central

    2016-01-01

    Behavioral flexibility is considered an important trait for adapting to environmental change, but it is unclear what it is, how it works, and whether it is a problem solving ability. I investigated behavioral flexibility and problem solving experimentally in great-tailed grackles, an invasive bird species and thus a likely candidate for possessing behavioral flexibility. Grackles demonstrated behavioral flexibility in two contexts, the Aesop’s Fable paradigm and a color association test. Contrary to predictions, behavioral flexibility did not correlate across contexts. Four out of 6 grackles exhibited efficient problem solving abilities, but problem solving efficiency did not appear to be directly linked with behavioral flexibility. Problem solving speed also did not significantly correlate with reversal learning scores, indicating that faster learners were not the most flexible. These results reveal how little we know about behavioral flexibility, and provide an immense opportunity for future research to explore how individuals and species can use behavior to react to changing environments. PMID:27168984

  8. Randomized controlled trial of a family problem-solving intervention.

    PubMed

    Drummond, Jane; Fleming, Darcy; McDonald, Linda; Kysela, Gerard M

    2005-02-01

    Adaptive problem solving contributes to individual and family health and development. In this article, the effect of the cooperative family learning approach (CFLA) on group family problem solving and on cooperative parenting communication is described. A pretest or posttest experimental design was used. Participant families were recruited from Head Start programs and exhibited two or more risk factors. Participant preschool children were screened to have two or more developmental delays. Direct behavioral observation measures were used to determine group family problem solving and cooperative parenting communication outcomes. Few group family problem-solving behaviors were coded, and they displayed little variability. However, intervention parents increased the length of time they played and extended the cooperative parent-child interactions. The evidence shows that CFLA has the potential to enhance parental-modeling of cooperative behavior while engaged in play activities with preschoolers. Direct measurement of group family problem solving was difficult. Solutions are suggested. PMID:15604228

  9. Autobiographical memory and social problem-solving in Asperger syndrome.

    PubMed

    Goddard, Lorna; Howlin, Patricia; Dritschel, Barbara; Patel, Trishna

    2007-02-01

    Difficulties in social interaction are a central feature of Asperger syndrome. Effective social interaction involves the ability to solve interpersonal problems as and when they occur. Here we examined social problem-solving in a group of adults with Asperger syndrome and control group matched for age, gender and IQ. We also assessed autobiographical memory, on a cueing task and during social problem-solving, and examined the relationship between access to specific past experiences and social problem-solving ability. Results demonstrated a social problem-solving impairment in the Asperger group. Their solutions were less detailed, less effective and less extended in time. Autobiographical memory performance was also impaired with significantly longer latencies to retrieve specific memories and fewer specific memories retrieved in comparison to controls. PMID:16874561

  10. THE ROLE OF PROBLEM SOLVING IN COMPLEX INTRAVERBAL REPERTOIRES

    PubMed Central

    Sautter, Rachael A; LeBlanc, Linda A; Jay, Allison A; Goldsmith, Tina R; Carr, James E

    2011-01-01

    We examined whether typically developing preschoolers could learn to use a problem-solving strategy that involved self-prompting with intraverbal chains to provide multiple responses to intraverbal categorization questions. Teaching the children to use the problem-solving strategy did not produce significant increases in target responses until problem solving was modeled and prompted. Following the model and prompts, all participants showed immediate significant increases in intraverbal categorization, and all prompts were quickly eliminated. Use of audible self-prompts was evident initially for all participants, but declined over time for 3 of the 4 children. Within-session response patterns remained consistent with use of the problem-solving strategy even when self-prompts were not audible. These findings suggest that teaching and prompting a problem-solving strategy can be an effective way to produce intraverbal categorization responses. PMID:21709781

  11. Growth promoting effect of hyaluronan synthesis promoting substances on Japanese eel leptocephali.

    PubMed

    Kawakami, Yutaka; Nomura, Kazuharu; Tanaka, Hideki

    2014-01-01

    Hyaluronans (HAs) are glycosaminoglycans produced in the bodies of Anguilliform and Elopiform leptocephali, and play a role in metabolic energy. In mammals, HA synthesis-promoting substances (HASPS) up-regulate the expression of HA synthase (HAS) and increase the amount of HA in the body. In this study, Japanese eel leptocephali were fed a HASPS containing diet. We analyzed HAS1s and HAS2 expression, HA content, and their influence on growth. HASPS extracted from Grifola frondosa promoted HAS1s and HAS2 mRNA and HA content. Other than mammals, these results are first reported in vertebrate. Moreover, HASPS extracted from G. frondosa promoted leptocephalus growth. The relationship between growth and HA in the leptocephali is not yet clear. However, based on our results we hypothesize that HA is involved in the storage of energy, which is metabolized to sugars when needed for metabolic energy. PMID:24896609

  12. How Indirect Supportive Digital Help during and after Solving Physics Problems Can Improve Problem-Solving Abilities

    ERIC Educational Resources Information Center

    Pol, Henk J.; Harskamp, Egbert G.; Suhre, Cor J. M.; Goedhart, Martin J.

    2009-01-01

    This study investigates the effectiveness of computer-delivered hints in relation to problem-solving abilities in two alternative indirect instruction schemes. In one instruction scheme, hints are available to students immediately after they are given a new problem to solve as well as after they have completed the problem. In the other scheme,…

  13. Impacts of Learning Inventive Problem-Solving Principles: Students' Transition from Systematic Searching to Heuristic Problem Solving

    ERIC Educational Resources Information Center

    Barak, Moshe

    2013-01-01

    This paper presents the outcomes of teaching an inventive problem-solving course in junior high schools in an attempt to deal with the current relative neglect of fostering students' creativity and problem-solving capabilities in traditional schooling. The method involves carrying out systematic manipulation with attributes, functions and…

  14. The Effects of a Problem Solving Intervention on Problem Solving Skills of Students with Autism during Vocational Tasks

    ERIC Educational Resources Information Center

    Yakubova, Gulnoza

    2013-01-01

    Problem solving is an important employability skill and considered valuable both in educational settings (Agran & Alper, 2000) and the workplace (Ju, Zhang, & Pacha, 2012). However, limited research exists instructing students with autism to engage in problem solving skills (e.g., Bernard-Opitz, Sriram, & Nakhoda-Sapuan, 2001). The…

  15. A Study of the Problem Solving Abilities of Seventh Grade Students Who Receive Anchored Problem Solving Instruction.

    ERIC Educational Resources Information Center

    Griesser, Sara Anne

    Current mathematics education emphasizes the importance of a problem solving mindset in the classroom. Students need to know how they are going to use what they are learning in real life. The purpose of this study was to determine the effect of anchored problem solving instruction on middle school students' mathematical abilities. The researcher…

  16. The Effects of Pair Problem Solving Technique Incorporating Polya's Problem Solving Strategy on Undergraduate Students' Performance in Chemistry

    ERIC Educational Resources Information Center

    Bilgin, Ibrahim

    2006-01-01

    The purpose of this study was to investigate the effects of pair problem solving technique incorporating Polya's problem solving strategy on undergraduate students' performance in conceptual and algorithmic questions in chemistry. The subjects of this study were 89 students enrolled from two first year chemistry classes. The experimental group was…

  17. Effects of the Problem Solving and Subject Matter Approaches on the Problem Solving Ability of Secondary School Agricultural Education

    ERIC Educational Resources Information Center

    Olowa, O. W.

    2009-01-01

    The approach used by teachers is very important to the success of the teaching process. This is why this study seeks to determine which teaching approaches--problem solving and subject-matter, would best improve the problem solving ability of selected secondary agricultural education students in Ikorodu Local Government Area. Ten classes and 150…

  18. How Do They Solve It? An Insight into the Learner's Approach to the Mechanism of Physics Problem Solving

    ERIC Educational Resources Information Center

    Hegde, Balasubrahmanya; Meera, B. N.

    2012-01-01

    A perceived difficulty is associated with physics problem solving from a learner's viewpoint, arising out of a multitude of reasons. In this paper, we have examined the microstructure of students' thought processes during physics problem solving by combining the analysis of responses to multiple-choice questions and semistructured student…

  19. Problem-solving skills in high school biology: The effectiveness of the IMMEX problem-solving assessment software

    NASA Astrophysics Data System (ADS)

    Palacio-Cayetano, Joycelin

    "Problem-solving through reflective thinking should be both the method and valuable outcome of science instruction in America's schools" proclaimed John Dewey (Gabel, 1995). If the development of problem-solving is a primary goal of science education, more problem-solving opportunities must be an integral part of K-16 education. To examine the effective use of technology in developing and assessing problem-solving skills, a problem-solving authoring, learning, and assessment software, the UCLA IMMEX Program-Interactive Multimedia Exercises-was investigated. This study was a twenty-week quasi-experimental study that was implemented as a control-group time series design among 120 tenth grade students. Both the experimental group (n = 60) and the control group (n = 60) participated in a problem-based learning curriculum; however, the experimental group received regular intensive experiences with IMMEX problem-solving and the control group did not. Problem-solving pretest and posttest were administered to all students. The instruments used were a 35-item Processes of Biological Inquiry Test and an IMMEX problem-solving assessment test, True Roots. Students who participated in the IMMEX Program achieved significant (p <.05) gains in problem-solving skills on both problem-solving assessment instruments. This study provided evidence that IMMEX software is highly efficient in evaluating salient elements of problem-solving. Outputs of students' problem-solving strategies revealed that unsuccessful problem solvers primarily used the following four strategies: (1) no data search strategy, students simply guessed; (2) limited data search strategy leading to insufficient data and premature closing; (3) irrelevant data search strategy, students focus in areas bearing no substantive data; and (4) extensive data search strategy with inadequate integration and analysis. On the contrary, successful problem solvers used the following strategies; (1) focused search strategy coupled

  20. Escaping mental fixation: incubation and inhibition in creative problem solving.

    PubMed

    Koppel, Rebecca H; Storm, Benjamin C

    2014-01-01

    The inhibition underlying retrieval-induced forgetting has been argued to play a crucial role in the ability to overcome interference in memory and cognition. Supporting this conjecture, recent research has found that participants who exhibit greater levels of retrieval-induced forgetting are better at overcoming fixation on the Remote Associates Test (RAT) than are participants who exhibit reduced levels of retrieval-induced forgetting. If the ability to inhibit inappropriate responses improves the ability to solve fixated RAT problems, then reducing the fixation caused by inappropriate responses should reduce the correlation between retrieval-induced forgetting and problem solving. We tested this hypothesis by inserting an incubation period between two 30-second problem-solving attempts: half of the participants were given an incubation period (distributed condition), half were not (continuous condition). In the continuous condition retrieval-induced forgetting correlated positively with problem-solving performance during both the initial and final 30 seconds of problem solving. In the distributed condition retrieval-induced forgetting only correlated with problem-solving performance during the first 30 seconds of problem solving. This finding suggests that incubation reduces the need for inhibition by reducing the extent to which problem solvers suffer fixation. PMID:23607286