Sample records for group committee c12

  1. 16 CFR 1018.12 - Statutory advisory committees.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Statutory advisory committees. 1018.12 Section 1018.12 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION GENERAL ADVISORY COMMITTEE MANAGEMENT Establishment of Advisory Committees § 1018.12 Statutory advisory committees. The Commission has...

  2. 7 CFR 955.12 - Committee.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE VIDALIA ONIONS GROWN IN GEORGIA Definitions § 955.12 Committee. Committee means the Vidalia Onion Committee, established pursuant to § 955.20. ...

  3. 7 CFR 955.12 - Committee.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE VIDALIA ONIONS GROWN IN GEORGIA Definitions § 955.12 Committee. Committee means the Vidalia Onion Committee, established pursuant to § 955.20. ...

  4. 7 CFR 955.12 - Committee.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE VIDALIA ONIONS GROWN IN GEORGIA Definitions § 955.12 Committee. Committee means the Vidalia Onion Committee, established pursuant to § 955.20. ...

  5. 7 CFR 955.12 - Committee.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE VIDALIA ONIONS GROWN IN GEORGIA Definitions § 955.12 Committee. Committee means the Vidalia Onion Committee, established pursuant to § 955.20. ...

  6. 7 CFR 955.12 - Committee.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE VIDALIA ONIONS GROWN IN GEORGIA Definitions § 955.12 Committee. Committee means the Vidalia Onion Committee, established pursuant to § 955.20. ...

  7. 12 CFR 1710.12 - Committees of board of directors.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Committees of board of directors. 1710.12 Section 1710.12 Banks and Banking OFFICE OF FEDERAL HOUSING ENTERPRISE OVERSIGHT, DEPARTMENT OF HOUSING... § 1710.12 Committees of board of directors. (a) General. The board of directors may rely, in directing...

  8. 16 CFR 16.12 - Termination of advisory committees.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Termination of advisory committees. 16.12 Section 16.12 Commercial Practices FEDERAL TRADE COMMISSION ORGANIZATION, PROCEDURES AND RULES OF PRACTICE ADVISORY COMMITTEE MANAGEMENT § 16.12 Termination of advisory committees. Any advisory committee shall...

  9. 50 CFR 100.12 - Local advisory committees.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false Local advisory committees. 100.12 Section... Structure § 100.12 Local advisory committees. (a) The Board shall establish such local Federal Advisory... in § 100.11. (b) Local Federal Advisory Committees, if established by the Board, shall operate in...

  10. 50 CFR 100.12 - Local advisory committees.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 8 2011-10-01 2011-10-01 false Local advisory committees. 100.12 Section... Structure § 100.12 Local advisory committees. (a) The Board shall establish such local Federal Advisory... in § 100.11. (b) Local Federal Advisory Committees, if established by the Board, shall operate in...

  11. 42 CFR 431.12 - Medical care advisory committee.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 4 2013-10-01 2013-10-01 false Medical care advisory committee. 431.12 Section 431... Medicaid agency about health and medical care services. (b) State plan requirement. A State plan must... Medicaid agency director about health and medical care services. (c) Appointment of members. The agency...

  12. 42 CFR 431.12 - Medical care advisory committee.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 4 2011-10-01 2011-10-01 false Medical care advisory committee. 431.12 Section 431... Medicaid agency about health and medical care services. (b) State plan requirement. A State plan must... Medicaid agency director about health and medical care services. (c) Appointment of members. The agency...

  13. 42 CFR 431.12 - Medical care advisory committee.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 4 2012-10-01 2012-10-01 false Medical care advisory committee. 431.12 Section 431... Medicaid agency about health and medical care services. (b) State plan requirement. A State plan must... Medicaid agency director about health and medical care services. (c) Appointment of members. The agency...

  14. 42 CFR 431.12 - Medical care advisory committee.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 4 2014-10-01 2014-10-01 false Medical care advisory committee. 431.12 Section 431... Medicaid agency about health and medical care services. (b) State plan requirement. A State plan must... Medicaid agency director about health and medical care services. (c) Appointment of members. The agency...

  15. 42 CFR 431.12 - Medical care advisory committee.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Medical care advisory committee. 431.12 Section 431... Medicaid agency about health and medical care services. (b) State plan requirement. A State plan must... Medicaid agency director about health and medical care services. (c) Appointment of members. The agency...

  16. 12 CFR 1273.9 - Audit Committee.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 9 2012-01-01 2012-01-01 false Audit Committee. 1273.9 Section 1273.9 Banks and Banking FEDERAL HOUSING FINANCE AGENCY FEDERAL HOME LOAN BANKS OFFICE OF FINANCE § 1273.9 Audit Committee. (a) Composition. The Independent Directors shall serve as the Audit Committee. The Audit...

  17. 12 CFR 1273.9 - Audit Committee.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 9 2013-01-01 2013-01-01 false Audit Committee. 1273.9 Section 1273.9 Banks and Banking FEDERAL HOUSING FINANCE AGENCY FEDERAL HOME LOAN BANKS OFFICE OF FINANCE § 1273.9 Audit Committee. (a) Composition. The Independent Directors shall serve as the Audit Committee. The Audit...

  18. 12 CFR 272.4 - Committee actions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Committee actions. 272.4 Section 272.4 Banks....4 Committee actions. (a) Actions at meetings. Actions are taken at meetings of the Committee except as described below. (b) Actions between meetings. Special circumstances may make it desirable in the...

  19. 36 CFR 242.12 - Local advisory committees.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 2 2013-07-01 2013-07-01 false Local advisory committees. 242.12 Section 242.12 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE... the existing State fish and game advisory committees do not adequately provide advice to, and assist...

  20. 36 CFR 242.12 - Local advisory committees.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 2 2012-07-01 2012-07-01 false Local advisory committees. 242.12 Section 242.12 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE... the existing State fish and game advisory committees do not adequately provide advice to, and assist...

  1. 36 CFR 242.12 - Local advisory committees.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 2 2014-07-01 2014-07-01 false Local advisory committees. 242.12 Section 242.12 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE... the existing State fish and game advisory committees do not adequately provide advice to, and assist...

  2. 44 CFR 12.16 - Reports about the advisory committees.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 44 Emergency Management and Assistance 1 2011-10-01 2011-10-01 false Reports about the advisory committees. 12.16 Section 12.16 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY GENERAL ADVISORY COMMITTEES § 12.16 Reports about the advisory committees. (a) The Agency will furnish a report of...

  3. 36 CFR 242.12 - Local advisory committees.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Local advisory committees... SUBSISTENCE MANAGEMENT REGULATIONS FOR PUBLIC LANDS IN ALASKA Program Structure § 242.12 Local advisory committees. (a) The Board shall establish such local Federal Advisory Committees within each region as...

  4. 36 CFR 242.12 - Local advisory committees.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 2 2011-07-01 2011-07-01 false Local advisory committees... SUBSISTENCE MANAGEMENT REGULATIONS FOR PUBLIC LANDS IN ALASKA Program Structure § 242.12 Local advisory committees. (a) The Board shall establish such local Federal Advisory Committees within each region as...

  5. 7 CFR 905.12 - Committee.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Committee. 905.12 Section 905.12 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE ORANGES, GRAPEFRUIT, TANGERINES, AND...

  6. 12 CFR 630.6 - Funding Corporation committees.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 6 2011-01-01 2011-01-01 false Funding Corporation committees. 630.6 Section... Corporation committees. (a) System Audit Committee. The Funding Corporation must establish and maintain a... must be free from any relationship that, in the opinion of the Funding Corporation board, would...

  7. 12 CFR 630.6 - Funding Corporation committees.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 7 2012-01-01 2012-01-01 false Funding Corporation committees. 630.6 Section... Corporation committees. (a) System Audit Committee. The Funding Corporation must establish and maintain a... must be free from any relationship that, in the opinion of the Funding Corporation board, would...

  8. 12 CFR 630.6 - Funding Corporation committees.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 7 2014-01-01 2014-01-01 false Funding Corporation committees. 630.6 Section... Corporation committees. (a) System Audit Committee. The Funding Corporation must establish and maintain a... must be free from any relationship that, in the opinion of the Funding Corporation board, would...

  9. 28 CFR 0.12 - Young American Medals Committee.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Office of the Attorney General § 0.12 Young American Medals Committee. There shall be in the Office of the Attorney General a Young American Medals Committee, which shall be composed of four members, one.... The Chairman of the Committee shall be designated by the Attorney General. The Committee shall issue...

  10. 12 CFR 272.2 - Functions of the Committee.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Functions of the Committee. 272.2 Section 272.2... § 272.2 Functions of the Committee. The procedures followed by the Committee are designed to facilitate the effective performance of the Committee's statutory functions with respect to the regulation and...

  11. 11 CFR 100.14 - State committee, subordinate committee, district, or local committee (2 U.S.C. 431(15)).

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 11 Federal Elections 1 2010-01-01 2010-01-01 false State committee, subordinate committee, district, or local committee (2 U.S.C. 431(15)). 100.14 Section 100.14 Federal Elections FEDERAL ELECTION COMMISSION GENERAL SCOPE AND DEFINITIONS (2 U.S.C. 431) General Definitions § 100.14 State committee...

  12. 29 CFR 1912.12 - Termination of advisory committees; renewal.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 7 2010-07-01 2010-07-01 false Termination of advisory committees; renewal. 1912.12 Section 1912.12 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) ADVISORY COMMITTEES ON STANDARDS Organizational Matters § 1912.12...

  13. 29 CFR 1912.12 - Termination of advisory committees; renewal.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 7 2011-07-01 2011-07-01 false Termination of advisory committees; renewal. 1912.12 Section 1912.12 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) ADVISORY COMMITTEES ON STANDARDS Organizational Matters § 1912.12...

  14. 5 CFR 1312.12 - Security Program Review Committee.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... CLASSIFICATION, DOWNGRADING, DECLASSIFICATION AND SAFEGUARDING OF NATIONAL SECURITY INFORMATION Classification and Declassification of National Security Information § 1312.12 Security Program Review Committee. The... 5 Administrative Personnel 3 2011-01-01 2011-01-01 false Security Program Review Committee. 1312...

  15. 5 CFR 1312.12 - Security Program Review Committee.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... CLASSIFICATION, DOWNGRADING, DECLASSIFICATION AND SAFEGUARDING OF NATIONAL SECURITY INFORMATION Classification and Declassification of National Security Information § 1312.12 Security Program Review Committee. The... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Security Program Review Committee. 1312...

  16. 77 FR 25706 - Notice of Advisory Committee Closed Meeting; U.S. Strategic Command Strategic Advisory Group

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-01

    ..., Command and Control, Science and Technology, Missile Defense. Meeting Accessibility: Pursuant to 5 U.S.C... DEPARTMENT OF DEFENSE Notice of Advisory Committee Closed Meeting; U.S. Strategic Command Strategic Advisory Group AGENCY: Department of Defense. ACTION: Notice of Advisory Committee closed meeting...

  17. 10 CFR 7.12 - Public participation in and public notice of advisory committee meetings.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Public participation in and public notice of advisory committee meetings. 7.12 Section 7.12 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.12 Public participation in and public notice of advisory committee meetings. (a) Each meeting of an NRC advisory committee...

  18. 10 CFR 7.12 - Public participation in and public notice of advisory committee meetings.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Public participation in and public notice of advisory committee meetings. 7.12 Section 7.12 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.12 Public participation in and public notice of advisory committee meetings. (a) Each meeting of an NRC advisory committee...

  19. 10 CFR 7.12 - Public participation in and public notice of advisory committee meetings.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Public participation in and public notice of advisory committee meetings. 7.12 Section 7.12 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.12 Public participation in and public notice of advisory committee meetings. (a) Each meeting of an NRC advisory committee...

  20. 10 CFR 7.12 - Public participation in and public notice of advisory committee meetings.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Public participation in and public notice of advisory committee meetings. 7.12 Section 7.12 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.12 Public participation in and public notice of advisory committee meetings. (a) Each meeting of an NRC advisory committee...

  1. 10 CFR 7.12 - Public participation in and public notice of advisory committee meetings.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Public participation in and public notice of advisory committee meetings. 7.12 Section 7.12 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.12 Public participation in and public notice of advisory committee meetings. (a) Each meeting of an NRC advisory committee...

  2. 15 CFR 2002.1 - Trade Policy Committee Review Group.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 15 Commerce and Foreign Trade 3 2014-01-01 2014-01-01 false Trade Policy Committee Review Group. 2002.1 Section 2002.1 Commerce and Foreign Trade Regulations Relating to Foreign Trade Agreements OFFICE OF THE UNITED STATES TRADE REPRESENTATIVE OPERATION OF COMMITTEES § 2002.1 Trade Policy Committee...

  3. 15 CFR 2002.1 - Trade Policy Committee Review Group.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 3 2011-01-01 2011-01-01 false Trade Policy Committee Review Group. 2002.1 Section 2002.1 Commerce and Foreign Trade Regulations Relating to Foreign Trade Agreements OFFICE OF THE UNITED STATES TRADE REPRESENTATIVE OPERATION OF COMMITTEES § 2002.1 Trade Policy Committee...

  4. 12 CFR 363.5 - Audit committees.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... committee shall include the appointment, compensation, and oversight of the independent public accountant... public accountant the basis for the reports issued under this part. (1) Each insured depository... members who are large customers of the subsidiary institution. (c) Independent public accountant...

  5. 12 CFR 363.5 - Audit committees.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... committee shall include the appointment, compensation, and oversight of the independent public accountant... public accountant the basis for the reports issued under this part. (1) Each insured depository... members who are large customers of the subsidiary institution. (c) Independent public accountant...

  6. 12 CFR 363.5 - Audit committees.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... committee shall include the appointment, compensation, and oversight of the independent public accountant... public accountant the basis for the reports issued under this part. (1) Each insured depository... members who are large customers of the subsidiary institution. (c) Independent public accountant...

  7. 12 CFR 363.5 - Audit committees.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... committee shall include the appointment, compensation, and oversight of the independent public accountant... public accountant the basis for the reports issued under this part. (1) Each insured depository... members who are large customers of the subsidiary institution. (c) Independent public accountant...

  8. 12 CFR 335.121 - Listing standards related to audit committees.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 5 2012-01-01 2012-01-01 false Listing standards related to audit committees... audit committees. The provisions of the applicable SEC regulation under section 10(A)(m) of the Exchange Act shall be followed as codified at 17 CFR part 240. [75 FR 73949, Nov. 30, 2010] ...

  9. 75 FR 76070 - Railroad Safety Advisory Committee (RSAC); Working Group Activity Update

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-07

    .... 65] Railroad Safety Advisory Committee (RSAC); Working Group Activity Update AGENCY: Federal Railroad... Committee (RSAC) Working Group Activities. SUMMARY: The FRA is updating its announcement of RSAC's Working.... [[Page 76071

  10. 75 FR 51525 - Railroad Safety Advisory Committee (RSAC); Working Group Activity Update

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-20

    .... 63] Railroad Safety Advisory Committee (RSAC); Working Group Activity Update AGENCY: Federal Railroad... Committee (RSAC) Working Group Activities. SUMMARY: The FRA is updating its announcement of RSAC's Working.... SUPPLEMENTARY INFORMATION: This notice serves to update FRA's last announcement of working group activities and...

  11. 75 FR 4904 - Railroad Safety Advisory Committee (RSAC); Working Group Activity Update

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-29

    ...-7257] Railroad Safety Advisory Committee (RSAC); Working Group Activity Update AGENCY: Federal Railroad... Committee (RSAC) Working Group Activities. SUMMARY: The FRA is updating its announcement of RSAC's Working... notice serves to update FRA's last announcement of working group activities and status reports of August...

  12. 77 FR 24257 - Railroad Safety Advisory Committee (RSAC); Working Group Activity Update

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-23

    .... 69] Railroad Safety Advisory Committee (RSAC); Working Group Activity Update AGENCY: Federal Railroad... Committee (RSAC) Working Group Activities. SUMMARY: The FRA is updating its announcement of the RSAC Working.... SUPPLEMENTARY INFORMATION: This notice serves to update FRA's last announcement of working group activities and...

  13. 77 FR 62513 - Federal Open Market Committee; Domestic Policy Directive of September 12-13, 2012

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-15

    .... William B. English, Secretary, Federal Open Market Committee. [FR Doc. 2012-25258 Filed 10-12-12; 8:45 am... FEDERAL RESERVE SYSTEM Federal Open Market Committee; Domestic Policy Directive of September 12-13, 2012 In accordance with Section 271.25 of its rules regarding availability of information (12 CFR part...

  14. 75 FR 51499 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Digital I&C...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-20

    ... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Digital I&C Systems The ACRS Subcommittee on Digital Instrumentation and Controls (I&C) Systems...: Wednesday, September 8, 2010--8:30 a.m. until 12 p.m. The Subcommittee will review Digital I&C Interim Staff...

  15. 78 FR 30267 - Notice of June 12 Advisory Committee on Voluntary Foreign Aid Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-22

    ... AGENCY FOR INTERNATIONAL DEVELOPMENT Notice of June 12 Advisory Committee on Voluntary Foreign Aid Meeting AGENCY: United States Agency for International Development. ACTION: Notice of meeting. SUMMARY... Committee on Voluntary Foreign Aid (ACVFA). Date: Wednesday, June 12, 2013. Time: 2:30 p.m. to 4:00 p.m...

  16. Tobacco control interest groups and their influence on parliamentary committees in Canada.

    PubMed

    Hastie, Robyn E; Kothari, Anita R

    2009-01-01

    The aim of this study was to determine how tobacco control interest groups influence tobacco policy decision-making through submissions and presentations to parliamentary committees. A qualitative content analysis was used to examine the presentations and submissions on tobacco-related legislation made to parliamentary committees between 1996 and 2004. The sample was identified from the public list of tobacco-related bills tabled in both the House of Commons and the Senate; the Government of Canada website and LEGISinfo were used to determine which committee reviewed the relevant bill. Committee clerks were asked to send submissions and presentations related to specific bills identified through LEGISinfo. Submissions and presentations were scanned and entered into QSR N6 software for coding. The coding instrument was adapted from previous studies employing qualitative content analysis. Montini and Bero's recommendations were used to evaluate the submissions and presentations. Tobacco control interest groups did present scientific evidence to support tobacco control. However, they underused credible witnesses to present information at meetings. The topics presented by tobacco control interests groups were usually relevant to the bill being discussed. Tobacco control interest groups employed some of the strategies suggested by Montini and Bero in their attempt to influence parliamentary committees through submissions and presentations. They did include scientific evidence in their submissions; however, they could improve their strategies in the area of using credible witnesses, such as scientists and medical experts. Incorporating Montini and Bero's recommendations into lobbying efforts may increase success in influencing committees.

  17. 76 FR 26771 - NASA Advisory Council; Task Group of the Science Committee; Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-09

    ... of the Science Committee; Meeting AGENCY: National Aeronautics and Space Administration. ACTION... the NASA Advisory Council (NAC) Science Committee. This Task Group reports to the Science Committee of the NAC. The Meeting will be held for the purpose of soliciting from the scientific community and...

  18. 76 FR 21073 - NASA Advisory Council; Task Group of the Science Committee; Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-14

    ... of the Science Committee; Meeting AGENCY: National Aeronautics and Space Administration. ACTION... the NASA Advisory Council (NAC) Science Committee. This Task Group reports to the Science Committee of the NAC. The Meeting will be held for the purpose of soliciting from the scientific community and...

  19. 78 FR 2996 - Federal Open Market Committee; Domestic Policy Directive of December 11-12, 2012

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-15

    ... FEDERAL RESERVE SYSTEM Federal Open Market Committee; Domestic Policy Directive of December 11-12... 271), there is set forth below the domestic policy directive issued by the Federal Open Market Committee at its meeting held on December 11-12, 2012.\\1\\ \\1\\ Copies of the Minutes of the Federal Open...

  20. 12 CFR 620.30 - Audit committees.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... resources to enable its audit committee to contract for external auditors, outside advisors, and ordinary... record in its minutes its agreement or disagreement with the item(s) under review. (2) External auditors. The external auditor must report directly to the audit committee. Each audit committee must: (i...

  1. 12 CFR 620.30 - Audit committees.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... resources to enable its audit committee to contract for external auditors, outside advisors, and ordinary... record in its minutes its agreement or disagreement with the item(s) under review. (2) External auditors. The external auditor must report directly to the audit committee. Each audit committee must: (i...

  2. 12 CFR 715.7 - Supervisory Committee audit alternatives to a financial statement audit.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Supervisory Committee audit alternatives to a financial statement audit. 715.7 Section 715.7 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS SUPERVISORY COMMITTEE AUDITS AND VERIFICATIONS § 715.7 Supervisory...

  3. 12 CFR 917.7 - Audit committees.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... internal auditor and that the internal auditor may be removed only with the approval of the audit committee; (ii) Provide that the internal auditor shall report directly to the audit committee on substantive matters and that the internal auditor is ultimately accountable to the audit committee and board of...

  4. 12 CFR 917.7 - Audit committees.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... internal auditor and that the internal auditor may be removed only with the approval of the audit committee; (ii) Provide that the internal auditor shall report directly to the audit committee on substantive matters and that the internal auditor is ultimately accountable to the audit committee and board of...

  5. Screening effects on 12C+12C fusion reaction

    NASA Astrophysics Data System (ADS)

    Koyuncu, F.; Soylu, A.

    2018-05-01

    One of the important reactions for nucleosynthesis in the carbon burning phase in high-mass stars is the 12C+12C fusion reaction. In this study, we investigate the influences of the nuclear potentials and screening effect on astrophysically interesting 12C+12C fusion reaction observables at sub-barrier energies by using the microscopic α–α double folding cluster (DFC) potential and the proximity potential. In order to model the screening effects on the experimental data, a more general exponential cosine screened Coulomb (MGECSC) potential including Debye and quantum plasma cases has been considered in the calculations for the 12C+12C fusion reaction. In the calculations of the reaction observables, the semi-classical Wentzel-Kramers-Brillouin (WKB) approach and coupled channel (CC) formalism have been used. Moreover, in order to investigate how the potentials between 12C nuclei produce molecular cluster states of 24Mg, the normalized resonant energy states of 24Mg cluster bands have been calculated for the DFC potential. By analyzing the results produced from the fusion of 12C+12C, it is found that taking into account the screening effects in terms of MGECSC is important for explaining the 12C+12C fusion data, and the microscopic DFC potential is better than the proximity potential in explaining the experimental data, also considering that clustering is dominant for the structure of the 24Mg nucleus. Supported by the Turkish Science and Research Council (TÜBİTAK) with (117R015)

  6. 12 CFR 630.6 - Funding Corporation committees.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Corporation committees. (a) System Audit Committee. The Funding Corporation must establish and maintain a System Audit Committee (SAC) by adopting a written charter describing the committee's composition..., compensation, and retention of external auditors issuing System-wide audit reports; (B) Review the external...

  7. 77 FR 14584 - Eleventh Meeting: RTCA Special Committee 217, Joint With EUROCAE Working Group-44, Terrain and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-12

    ... Committee 217, Joint With EUROCAE Working Group--44, Terrain and Airport Mapping Databases AGENCY: Federal... Special Committee 217, Joint with EUROCAE Working Group--44, Terrain and Airport Mapping Databases... Committee 217, Joint with EUROCAE Working Group--44, Terrain and Airport Mapping Databases. DATES: The...

  8. 76 FR 58078 - Thirteenth Meeting: RTCA Special Committee 214: Working Group 78: Standards for Air Traffic Data...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-19

    ... Committee 214: Working Group 78: Standards for Air Traffic Data Communication Services AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of RTCA Special Committee 214: Working Group 78... public of a meeting of the RTCA Special Committee 214: Working Group 78: Standards for Air Traffic Data...

  9. Lineage II (Serovar 1/2a and 1/2c) Human Listeria monocytogenes Pulsed-Field Gel Electrophoresis Types Divided into PFGE Groups Using the Band Patterns Below 145.5 kb.

    PubMed

    Lopez-Valladares, Gloria; Danielsson-Tham, Marie-Louise; Goering, Richard V; Tham, Wilhelm

    2017-01-01

    Among 504 clinical lineage II isolates of Listeria monocytogenes isolated during 1958-2010 in Sweden, 119 pulsed-field gel electrophoresis (PFGE) types (AscI) have been identified based on the number and distribution of all banding patterns in each DNA profile. In this study, these types were further divided into PFGE groups based on the configuration of small bands with sizes <145.5 kb. The 504 isolates included 483 serovar 1/2a isolates distributed into 114 PFGE types and 21 serovar 1/2c isolates distributed into 9 PFGE types; these were further divided into 21 PFGE groups. PFGE group, that is, configuration of small bands below 145.5 kb, and serovars were correlated. L. monocytogenes isolates belonging to PFGE groups A, B, C, E, F, H, K, L, M, S, V, W, Y, and Ö-6 to Ö-12 shared serovar 1/2a, with one exception. PFGE group E also included two PFGE types sharing serovar 1/2c and four PFGE types belonging to either serovar 1/2a or 1/2c. Isolates belonging to PFGE group N shared serovar 1/2c. In contrast to lineage I isolates, small fragments <33.3 kb were visible in all L. monocytogenes isolates belonging to lineage II. In the results from both the present and previous studies, the genomic region of small bands was genetically more conservative than in large bands. The distribution of these small bands established the relatedness of strains and defined a genetic marker for both lineages I and II, while also establishing their serogroup. The division of L. monocytogenes PFGE types into PFGE groups is advantageous as the profile of every new isolate can be identified easily and quickly through first studying the PFGE group affiliation of the isolate based on the smaller band patterns <145.5 kb, and then identifying the PFGE type based on the band patterns >145.5 kb.

  10. 77 FR 8877 - ICD-9-CM Coordination and Maintenance (C&M) Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-15

    ... Coordination and Maintenance (C&M) Committee Meeting National Center for Health Statistics (NCHS... Coordination and Maintenance (C&M) Committee meeting. Time and Date: 9 a.m.-5:30 p.m., March 5, 2012. Place... entering the building. Attendees who wish to attend the ICD- 9-CM C&M meeting on March 5, 2012, must submit...

  11. 42 CFR 456.206 - Organization and composition of UR committee; disqualification from UR committee membership.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... UTILIZATION CONTROL Utilization Control: Mental Hospitals Ur Plan: Administrative Requirements § 456.206... the diagnosis and treatment of mental diseases, and assisted by other professional personnel. (c) The UR committee must be constituted as— (1) A committee of the mental hospital staff; (2) A group...

  12. 11 CFR 102.14 - Names of political committees (2 U.S.C. 432(e) (4) and (5)).

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 11 Federal Elections 1 2010-01-01 2010-01-01 false Names of political committees (2 U.S.C. 432(e... REGISTRATION, ORGANIZATION, AND RECORDKEEPING BY POLITICAL COMMITTEES (2 U.S.C. 433) § 102.14 Names of political committees (2 U.S.C. 432(e) (4) and (5)). (a) The name of each authorized committee shall include...

  13. Cross section measurements in the 12C+12C system

    NASA Astrophysics Data System (ADS)

    Courtin, S.; Jiang, C. L.; Fruet, G.; Heine, M.; Jenkins, D. G.; Adsley, P.; Morris, L. G.; Regan, P. H.; Rudigier, M.; Montanari, D.; Della Negra, S.; de Séréville, N.; Haas, F.; Hammache, F.; Kirsebom, O. S.; Lesrel, J.; Meyer, A.; Montanari, D.; Auranen, K.; Avila, M. L.; Ayangeakaa, A. D.; Back, B. B.; Bottoni, S.; Carpenter, M.; Dickerson, C.; DiGiovine, B.; Greene, J. P.; Henderson, D. J.; Hoffman, C. R.; Janssens, R. V. F.; Kay, B. P.; Kuvin, S. A.; Lauritsen, T.; Pardo, R. C.; Rehm, K. E.; Santiago-Gonzalez, D.; Sethi, J.; Seweryniak, D.; Talwar, R.; Ugalde, C.; Zhu, S.; Deibel, C. M.; Marley, S. T.; Bourgin, D.; Stodel, C.; Lefebvre-Schuhl, A.; Almaraz-Calderon, S.; Fang, X.; Tang, X. D.; Alcorta, M.; Bucher, B.; Albers, M.; Bertone, P.

    2018-01-01

    The 12C+12C fusion reaction is one of the most important for nuclear astrophysics since it determines the carbon ignition in stellar environments. Two experiments which make use of the gamma-particle coincidence technique to measure the 12C+12C S-factors at deep sub barrier energies are discussed. Results are presented showing a decrease of the S-factor below Ec.m. = 3 MeV.

  14. 12 CFR 363.5 - Audit committees.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... employee of the institution or any affiliate of the institution. (b) Committees of large institutions. The... engagement letters. (1) In performing its duties with respect to the appointment of the institution's independent public accountant, the audit committee shall ensure that engagement letters and any related...

  15. 75 FR 8310 - Federal Advisory Committee; Transformation Advisory Group; Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-24

    ... DEPARTMENT OF DEFENSE Office of the Secretary Federal Advisory Committee; Transformation Advisory... announces that the Transformation Advisory Group will hold a closed meeting on March 11, 2010. DATES: The... written statements to the membership of the Transformation Advisory Group at any time or in response to...

  16. 12 CFR 620.31 - Compensation committees.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... association must establish and maintain a compensation committee by adopting a written charter describing the... committees will be required to maintain records of meetings, including attendance, for at least 3 fiscal... any relationship that, in the opinion of the board, would interfere with the exercise of independent...

  17. 11 CFR 100.5 - Political committee (2 U.S.C. 431 (4), (5), (6)).

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... delegate at 11 CFR 110.14(b)(1).) (6) Leadership PAC. Leadership PAC means a political committee that is... that leadership PAC does not include a political committee of a political party. (7) Lobbyist... informal practices or procedures; (C) Whether a sponsoring organization or committee has the authority or...

  18. 11 CFR 102.2 - Statement of organization: Forms and committee identification number (2 U.S.C. 433 (b), (c)).

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... boxes, or other depositories used by the committee; (vii) The Internet address of the committee's... on all communications concerning reports and statements. [45 FR 15104, Mar. 7, 1980, as amended at 50 FR 50778, Dec. 12, 1985; 54 FR 34109, Aug. 17, 1989; 54 FR 48580, Nov. 24, 1989; 58 FR 42173, Aug. 6...

  19. 76 FR 60811 - Notice of Advisory Committee Closed Meeting; U.S. Strategic Command Strategic Advisory Group...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-30

    ... DEPARTMENT OF DEFENSE Notice of Advisory Committee Closed Meeting; U.S. Strategic Command Strategic Advisory Group; Correction AGENCY: Department of Defense. ACTION: Notice of Advisory Committee... Command Strategic Advisory Group gave notice of a meeting to be held on November 1, 2011, from 8 a.m. to 5...

  20. Differential susceptibility of C2C12 myoblasts and myotubes to group II phospholipase A2 myotoxins from crotalid snake venoms.

    PubMed

    Angulo, Yamileth; Lomonte, Bruno

    2005-01-01

    Group II phospholipase A(2) (PLA(2)) myotoxins isolated from Viperidae/Crotalidae snake venoms induce a rapid cytolytic effect upon diverse cell types in vitro. Previous studies suggested that this effect could be more pronounced on skeletal muscle myotubes than on other cell types, including undifferentiated myoblasts. This study utilized the murine skeletal muscle C2C12 cell line to investigate whether differentiated myotubes are more susceptible than myoblasts, and if this characteristic is specific for the group II myotoxic PLA(2)s. The release of lactic dehydrogenase was quantified as a measure of cytolysis, 3 h after cell exposure to different group II PLA(2)s purified from Bothrops asper, Atropoides nummifer, Cerrophidion godmani, and Bothriechis schlegelii venoms. In addition, susceptibility to lysis induced by synthetic melittin and group III PLA(2) from bee (Apis mellifera) venom, as well as by anionic, cationic, and neutral detergents, was comparatively evaluated on the two cultures. Myotubes were significantly more susceptible to group II PLA(2) myotoxins, but not to the other agents tested, under the same conditions. Moreover, the increased susceptibility of myotubes over myoblasts was also demonstrated with two cytolytic synthetic peptides, derived from the C-terminal region of Lys49 PLA(2) myotoxins, that reproduce the action of their parent proteins. These results indicate that fusion and differentiation of myoblasts into myotubes induce changes that render these cells more susceptible to the toxic mechanism of group II PLA(2) myotoxins, but not to general perturbations of membrane homeostasis. Such changes are likely to involve myotoxin acceptor site(s), which remain(s) to be identified.

  1. 76 FR 5779 - Fruit and Vegetable Industry Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-02

    ... U.S.C. App. II), the Secretary of Agriculture established the Committee in August 2001 to examine..., commodity purchasing programs, and working group reports and recommendations to the full committee. Those...

  2. 76 FR 62804 - Notice of FERC Staff Attendance at the Entergy Regional State Committee Work Group and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-11

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Notice of FERC Staff Attendance at the Entergy Regional State Committee Work Group and Stakeholder Meeting The Federal Energy Regulatory... is part of the Commission's ongoing outreach efforts. Entergy Regional State Committee Work Group and...

  3. 75 FR 47535 - Fruit and Vegetable Industry Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-06

    ... (FACA) (5 U.S.C. App. II), the Secretary of Agriculture established the Committee in August 2001 to..., commodity purchasing programs, and working group reports and recommendations to the full committee. Those...

  4. 40 CFR 721.3025 - Fatty acids C12-18, C18 unsaturated, C12-18 alkyl esters (generic).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Fatty acids C12-18, C18 unsaturated... Significant New Uses for Specific Chemical Substances § 721.3025 Fatty acids C12-18, C18 unsaturated, C12-18... chemical substance identified generically as fatty acids C12-18, C18 unsaturated, C12-18 alkyl esters (PMNs...

  5. 75 FR 27557 - Federal Advisory Committee Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-17

    ... the charter for the Advisory Committee for the 2012 Radiocommunication Conference (WRC-12 Advisory Committee), for a two-year period. The WRC-12 Advisory Committee is a Federal advisory committee under the... CONTACT: Alexander Roytblat, Designated Federal Official, WRC-12 Advisory Committee, FCC International...

  6. 12 CFR 272.2 - Functions of the Committee.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... § 272.2 Functions of the Committee. The procedures followed by the Committee are designed to facilitate.... Such policy actions ordinarily are taken through the adoption and transmission to the Federal Reserve...

  7. 12 CFR 272.2 - Functions of the Committee.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... § 272.2 Functions of the Committee. The procedures followed by the Committee are designed to facilitate.... Such policy actions ordinarily are taken through the adoption and transmission to the Federal Reserve...

  8. 12 CFR 272.2 - Functions of the Committee.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... § 272.2 Functions of the Committee. The procedures followed by the Committee are designed to facilitate.... Such policy actions ordinarily are taken through the adoption and transmission to the Federal Reserve...

  9. On spectral temperatures of negative pions produced in d{sup 12}C, {sup 4}He{sup 12}C, and {sup 12}C{sup 12}C collisions at 4.2 A GeV/c

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Olimov, Kh. K., E-mail: olimov@comsats.edu.pk; Haseeb, Mahnaz Q., E-mail: mahnazhaseeb@comsats.edu.pk

    2013-05-15

    The experimental transverse momentum distributions of negative pions produced in d{sup 12}C, {sup 4}He{sup 12}C, and {sup 12}C{sup 12}C collisions at 4.2 A GeV/c were analyzed in the framework of Hagedorn Thermodynamic Model. The spectral temperatures of {pi}{sup -} mesons as well as their relative contributions to the total multiplicity of {pi}{sup -} mesons were extracted from fitting the p{sub t} spectra by two-temperature Hagedorn function. The results were compared systematically with the earlier results obtained from analysis of non-invariant center-of-mass energy spectra of negative pions produced in the analyzed collisions.

  10. 11 CFR 105.4 - Place of filing; political committees and other persons (2 U.S.C. 432(g)(4)).

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 11 Federal Elections 1 2010-01-01 2010-01-01 false Place of filing; political committees and other... DOCUMENT FILING (2 U.S.C. 432(g)) § 105.4 Place of filing; political committees and other persons (2 U.S.C... amendments thereto, required to be filed under 11 CFR parts 101, 102, and 104 by a political committee other...

  11. 44 CFR 12.6 - Establishment of advisory committees.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... the advisory committee to be fairly balanced in terms of the points of view represented in the... employed by it), will be provided adequate quarters, and will have funds available to meet its other... should describe the Agency's plan to attain balanced membership on the proposed committee, as prescribed...

  12. Measurement of the ^12C+^12C Fusion Reaction with MUSIC

    NASA Astrophysics Data System (ADS)

    Carnelli, P. F. F.; Almaraz-Calderon, S.; Henderson, D.; Rehm, K. E.; Albers, M.; Alcorta, M.; Bertone, P. F.; Esbensen, H.; Fernandez-Niello, J. O.; Jiang, C. L.; Lighthall, J. C.; Marley, S. T.; Palchan-Hazan, T.; Pardo, R. C.; Paul, M.

    2012-10-01

    The fusion of the ^12C+^12C system is of great interest in nuclear structure and nuclear astrophysics. Above the Coulomb barrier, the excitation function of this system exhibits oscillations, which are not well understood. There is also a significant discrepancy between the experimental fusion cross-section and recent coupled-channel calculations that is not present in other carbon systems. To address these issues, we have re-measured the fusion excitation function for ^12,13C+^12C in the energy range of 10 MeV < Ecm < 20 MeV using a Multi-Sampling Ionization Chamber (MUSIC) detector. The gas of the ionization chamber (CH4) served as both the target material and the counter gas. One of the main advantages of this method is that the excitation function is measured over a large range of energies using only one beam energy. This method has been proven to be successful and it will be used to measure fusion reactions in other light systems. The experimental results will be presented and compared to previous experimental data and theoretical models.

  13. How do small groups make decisions? : A theoretical framework to inform the implementation and study of clinical competency committees.

    PubMed

    Chahine, Saad; Cristancho, Sayra; Padgett, Jessica; Lingard, Lorelei

    2017-06-01

    In the competency-based medical education (CBME) approach, clinical competency committees are responsible for making decisions about trainees' competence. However, we currently lack a theoretical model for group decision-making to inform this emerging assessment phenomenon. This paper proposes an organizing framework to study and guide the decision-making processes of clinical competency committees.This is an explanatory, non-exhaustive review, tailored to identify relevant theoretical and evidence-based papers related to small group decision-making. The search was conducted using Google Scholar, Web of Science, MEDLINE, ERIC, and PsycINFO for relevant literature. Using a thematic analysis, two researchers (SC & JP) met four times between April-June 2016 to consolidate the literature included in this review.Three theoretical orientations towards group decision-making emerged from the review: schema, constructivist, and social influence. Schema orientations focus on how groups use algorithms for decision-making. Constructivist orientations focus on how groups construct their shared understanding. Social influence orientations focus on how individual members influence the group's perspective on a decision. Moderators of decision-making relevant to all orientations include: guidelines, stressors, authority, and leadership.Clinical competency committees are the mechanisms by which groups of clinicians will be in charge of interpreting multiple assessment data points and coming to a shared decision about trainee competence. The way in which these committees make decisions can have huge implications for trainee progression and, ultimately, patient care. Therefore, there is a pressing need to build the science of how such group decision-making works in practice. This synthesis suggests a preliminary organizing framework that can be used in the implementation and study of clinical competency committees.

  14. 75 FR 14471 - Advisory Committee on Construction Safety and Health (ACCSH)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-25

    ... Houston, TX. In conjunction with ACCSH's meeting, its Work Groups will meet April 12 and 13, 2010. DATES... materials and requests submitted to the Committee. ACCSH Work Group Meetings In conjunction with the ACCSH...

  15. 78 FR 24289 - Aviation Rulemaking Advisory Committee (ARAC) Airman Testing Standards and Training Working Group...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-24

    ... Rulemaking Advisory Committee (ARAC) Airman Testing Standards and Training Working Group (ATSTWG) AGENCY... FAA will post all comments it receives, without change, to http://www.regulations.gov , including any... several draft documents developed by the Airman Testing Standards and Training Working Group. The...

  16. 11 CFR 104.4 - Independent expenditures by political committees (2 U.S.C. 434(b), (d), and (g)).

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 11 Federal Elections 1 2010-01-01 2010-01-01 false Independent expenditures by political... GENERAL REPORTS BY POLITICAL COMMITTEES AND OTHER PERSONS (2 U.S.C. 434) § 104.4 Independent expenditures by political committees (2 U.S.C. 434(b), (d), and (g)). (a) Regularly scheduled reporting. Every...

  17. 41 CFR 102-3.40 - What types of committees or groups are not covered by the Act and this part?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Sciences (NAS) or the National Academy of Public Administration (NAPA). Any committee created by NAS or... assembled to exchange facts or information. Any group that meets with a Federal official(s) for the purpose of exchanging facts or information; (g) Intergovernmental committees. Any committee composed wholly...

  18. 41 CFR 102-3.40 - What types of committees or groups are not covered by the Act and this part?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Sciences (NAS) or the National Academy of Public Administration (NAPA). Any committee created by NAS or... assembled to exchange facts or information. Any group that meets with a Federal official(s) for the purpose of exchanging facts or information; (g) Intergovernmental committees. Any committee composed wholly...

  19. 41 CFR 102-3.40 - What types of committees or groups are not covered by the Act and this part?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Sciences (NAS) or the National Academy of Public Administration (NAPA). Any committee created by NAS or... assembled to exchange facts or information. Any group that meets with a Federal official(s) for the purpose of exchanging facts or information; (g) Intergovernmental committees. Any committee composed wholly...

  20. 41 CFR 102-3.40 - What types of committees or groups are not covered by the Act and this part?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Sciences (NAS) or the National Academy of Public Administration (NAPA). Any committee created by NAS or... assembled to exchange facts or information. Any group that meets with a Federal official(s) for the purpose of exchanging facts or information; (g) Intergovernmental committees. Any committee composed wholly...

  1. 41 CFR 102-3.40 - What types of committees or groups are not covered by the Act and this part?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Sciences (NAS) or the National Academy of Public Administration (NAPA). Any committee created by NAS or... assembled to exchange facts or information. Any group that meets with a Federal official(s) for the purpose of exchanging facts or information; (g) Intergovernmental committees. Any committee composed wholly...

  2. First Direct Measurement of C 12 ( C 12 , n ) Mg 23 at Stellar Energies

    DOE PAGES

    Bucher, B.; Tang, X. D.; Fang, X.; ...

    2015-06-25

    Neutrons produced by the carbon fusion reaction 12C( 12C,n) 23Mg play an important role in stellar nucleosynthesis. However, past studies have shown large discrepancies between experimental data and theory, leading to an uncertain cross section extrapolation at astrophysical energies. Here in this paper, we present the first direct measurement that extends deep into the astrophysical energy range along with a new and improved extrapolation technique based on experimental data from the mirror reaction 12C( 12C,p) 23Na . The new reaction rate has been determined with a well-defined uncertainty that exceeds the precision required by astrophysics models. Using our constrained rate,more » we find that 12C ( 12C,n) 23Mg is crucial to the production of Na and Al in pop-III pair instability supernovae. It also plays a nonnegligible role in the production of weak s -process elements, as well as in the production of the important galactic γ-ray emitter 60Fe.« less

  3. 77 FR 71028 - Twelfth Meeting: RTCA Special Committee 223, Airport Surface Wireless Communications

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-28

    ... by Special Committee Leadership Agenda Overview Review/Approve prior Plenary Meeting Summary and... committee at any time. Issued in Washington, DC, on November 8, 2012. Richard F. Gonzalez, Management Analyst, Business Operations Group, Federal Aviation Administration. [FR Doc. 2012-28854 Filed 11-27-12; 8...

  4. 15 CFR 2002.1 - Trade Policy Committee Review Group.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... OFFICE OF THE UNITED STATES TRADE REPRESENTATIVE OPERATION OF COMMITTEES § 2002.1 Trade Policy Committee..., December 11, 1971 (15 CFR 2002.1), is abolished and there is hereby established as a subordinate body of...

  5. Studies on the Selectivity Between Nickel-Catalyzed 1,2-Cis-2-Amino Glycosylation of Hydroxyl Groups of Thioglycoside Acceptors with C(2)-Substituted Benzylidene N-Phenyl Trifluoroacetimidates and Intermolecular Aglycon Transfer of the Sulfide Group

    PubMed Central

    Yu, Fei; Nguyen, Hien M.

    2012-01-01

    The stereoselective synthesis of saccharide thioglycosides containing 1,2-cis-2-amino glycosidic linkages is challenging. In addition to the difficulties associated with achieving high α-selectivity in the formation of 1,2-cis-2-amino glycosidic bonds, the glycosylation reaction is hampered by undesired transfer of the anomeric sulfide group from the glycosyl acceptor to the glycosyl donor. Overcoming these obstacles will pave the way for the preparation of oligosaccharides and glycoconjugates bearing the 1,2-cis-2-amino glycosidic linkages because the saccharide thioglycosides obtained can serve as donors for another coupling iteration. This approach streamlines selective deprotection and anomeric derivatization steps prior to the subsequent coupling event. We have developed an efficient approach for the synthesis of highly yielding and α-selective saccharide thioglycosides containing 1,2-cis-2-amino glycosidic bonds, via cationic nickel-catalyzed glycosylation of thioglycoside acceptors bearing the 2-trifluoromethylphenyl aglycon with N-phenyl trifluoroacetimidate donors. The 2-trifluoromethylphenyl group effectively blocks transfer of the anomeric sulfide group from the glycosyl acceptor to the C(2)-benzylidene donor and can be easily installed and activated. The current method also highlights the efficacy of the nickel catalyst selectively activating the C(2)-benzylidene imidate group in the presence of the anomeric sulfide group on the glycosyl acceptors. PMID:22838405

  6. 76 FR 20051 - Advisory Committee for International Science & Engineering; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-11

    ... NATIONAL SCIENCE FOUNDATION Advisory Committee for International Science & Engineering; Notice of... Engineering ( 25104). Date/Time: April 25, 2011; 8:30 a.m. to 5 p.m. April 26, 2011; 8:30 a.m. to 12 p.m... International Science and Engineering, Reports from Advisory Committee Working Groups. April 26, 2011 AM...

  7. 78 FR 55336 - Membership in the National Parks Overflights Advisory Group Aviation Rulemaking Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-10

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Membership in the National Parks Overflights Advisory Group Aviation Rulemaking Committee AGENCY: Federal Aviation Administration... Park Service (NPS) and the Federal Aviation Administration (FAA) invited interested persons to apply to...

  8. 78 FR 25338 - Membership in the National Parks Overflights Advisory Group Aviation Rulemaking Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-30

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Membership in the National Parks Overflights Advisory Group Aviation Rulemaking Committee AGENCY: Federal Aviation Administration... the Federal Aviation Administration (FAA) invited interested persons to apply to fill one opening on...

  9. Measurement and significance of the equilibrium reaction C-13/+/ + /C-12/O yields C-12/+/ + /C-13/O for alteration of the C-13/C-12 ratio in interstellar molecules

    NASA Technical Reports Server (NTRS)

    Watson, W. D.; Anicich, V. G.; Huntress, W. T., Jr.

    1976-01-01

    Laboratory measurements using the ion-cyclotron resonance technique yield a rate constant of 2 by 10 to the -10th power cu cm/sec at 300 K for the isotope exchange C-13(+) + (C-12)O yields C-12(+) + (C-13)O. According to the usual ideas about ion-molecule reactions, this rate constant should also be appropriate at temperatures not exceeding about 100 K. Then the observed C-13/C-12 ratio obtained from radio observation of interstellar molecules may be either larger or smaller than the actual value in the interstellar medium by factors of 2 or so. If the ratio is altered from the actual interstellar value, it will not be the same in all molecules, and CO will tend to have the highest value. The chief astronomical uncertainty for the occurrence of this isotope fractionation is the abundance of 'unobservable' molecules which can react rapidly with C(+): e.g., O2, H2O, CO2, and CH4. If their abundance is greater than about one-tenth that of CO, the isotope fractionation will be inhibited.

  10. 77 FR 65581 - Labor Advisory Committee for Trade Negotiations and Trade Policy

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-29

    ... DEPARTMENT OF LABOR Office of the Secretary Labor Advisory Committee for Trade Negotiations and... Committee for Trade Negotiation and Trade Policy. Date, Time, Place: November 13, 2012; 10:00 a.m.-12:00 p.m... negotiations will be discussed. Pursuant to 19 U.S.C. 2155(f), it has been determined that the meeting will be...

  11. An increase in the 12C + 12C fusion rate from resonances at astrophysical energies.

    PubMed

    Tumino, A; Spitaleri, C; La Cognata, M; Cherubini, S; Guardo, G L; Gulino, M; Hayakawa, S; Indelicato, I; Lamia, L; Petrascu, H; Pizzone, R G; Puglia, S M R; Rapisarda, G G; Romano, S; Sergi, M L; Spartá, R; Trache, L

    2018-05-01

    Carbon burning powers scenarios that influence the fate of stars, such as the late evolutionary stages of massive stars 1 (exceeding eight solar masses) and superbursts from accreting neutron stars 2,3 . It proceeds through the 12 C +  12 C fusion reactions that produce an alpha particle and neon-20 or a proton and sodium-23-that is, 12 C( 12 C, α) 20 Ne and 12 C( 12 C, p) 23 Na-at temperatures greater than 0.4 × 10 9 kelvin, corresponding to astrophysical energies exceeding a megaelectronvolt, at which such nuclear reactions are more likely to occur in stars. The cross-sections 4 for those carbon fusion reactions (probabilities that are required to calculate the rate of the reactions) have hitherto not been measured at the Gamow peaks 4 below 2 megaelectronvolts because of exponential suppression arising from the Coulomb barrier. The reference rate 5 at temperatures below 1.2 × 10 9 kelvin relies on extrapolations that ignore the effects of possible low-lying resonances. Here we report the measurement of the 12 C( 12 C, α 0,1 ) 20 Ne and 12 C( 12 C, p 0,1 ) 23 Na reaction rates (where the subscripts 0 and 1 stand for the ground and first excited states of 20 Ne and 23 Na, respectively) at centre-of-mass energies from 2.7 to 0.8 megaelectronvolts using the Trojan Horse method 6,7 and the deuteron in 14 N. The cross-sections deduced exhibit several resonances that are responsible for very large increases of the reaction rate at relevant temperatures. In particular, around 5 × 10 8 kelvin, the reaction rate is boosted to more than 25 times larger than the reference value 5 . This finding may have implications such as lowering the temperatures and densities 8 required for the ignition of carbon burning in massive stars and decreasing the superburst ignition depth in accreting neutron stars to reconcile observations with theoretical models 3 .

  12. 77 FR 3030 - Membership in the National Parks Overflights Advisory Group Aviation Rulemaking Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-20

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Membership in the National Parks Overflights Advisory Group Aviation Rulemaking Committee ACTION: Notice. SUMMARY: By Federal Register notice (See 76 FR 65319; October 20, 2011) the National Park Service (NPS) and the Federal Aviation...

  13. Molecular structure of Ti8C12 and related complexes.

    PubMed Central

    Pauling, L

    1992-01-01

    Application of valence-bond theory leads to the assignment to the molecule Ti8C12 of a cubic structure, point group Ohm3m, with 8 Ti at the cube corners, +/-(x x x, x, x x [symbol, see text]) where x = 1.78 A, and with 12 C in pairs in the cube faces, +/-(0 y z, [symbol, see text], 0, y z [symbol, see text]) where y = 1.78 A and z = 0.71 A. The Ti-C and C-C bonds have bond number 4/3, corresponding to resonance of single and double bonds in 2:1 ratio. PMID:11607323

  14. Ensuring Resident Competence: A Narrative Review of the Literature on Group Decision Making to Inform the Work of Clinical Competency Committees.

    PubMed

    Hauer, Karen E; Cate, Olle Ten; Boscardin, Christy K; Iobst, William; Holmboe, Eric S; Chesluk, Benjamin; Baron, Robert B; O'Sullivan, Patricia S

    2016-05-01

    Background The expectation for graduate medical education programs to ensure that trainees are progressing toward competence for unsupervised practice prompted requirements for a committee to make decisions regarding residents' progress, termed a clinical competency committee (CCC). The literature on the composition of these committees and how they share information and render decisions can inform the work of CCCs by highlighting vulnerabilities and best practices. Objective We conducted a narrative review of the literature on group decision making that can help characterize the work of CCCs, including how they are populated and how they use information. Methods English language studies of group decision making in medical education, psychology, and organizational behavior were used. Results The results highlighted 2 major themes. Group member composition showcased the value placed on the complementarity of members' experience and lessons they had learned about performance review through their teaching and committee work. Group processes revealed strengths and limitations in groups' understanding of their work, leader role, and information-sharing procedures. Time pressure was a threat to the quality of group work. Conclusions Implications of the findings include the risks for committees that arise with homogeneous membership, limitations to available resident performance information, and processes that arise through experience rather than deriving from a well-articulated purpose of their work. Recommendations are presented to maximize the effectiveness of CCC processes, including their membership and access to, and interpretation of, information to yield evidence-based, well-reasoned judgments.

  15. Ensuring Resident Competence: A Narrative Review of the Literature on Group Decision Making to Inform the Work of Clinical Competency Committees

    PubMed Central

    Hauer, Karen E.; Cate, Olle ten; Boscardin, Christy K.; Iobst, William; Holmboe, Eric S.; Chesluk, Benjamin; Baron, Robert B.; O'Sullivan, Patricia S.

    2016-01-01

    Background The expectation for graduate medical education programs to ensure that trainees are progressing toward competence for unsupervised practice prompted requirements for a committee to make decisions regarding residents' progress, termed a clinical competency committee (CCC). The literature on the composition of these committees and how they share information and render decisions can inform the work of CCCs by highlighting vulnerabilities and best practices. Objective We conducted a narrative review of the literature on group decision making that can help characterize the work of CCCs, including how they are populated and how they use information. Methods English language studies of group decision making in medical education, psychology, and organizational behavior were used. Results The results highlighted 2 major themes. Group member composition showcased the value placed on the complementarity of members' experience and lessons they had learned about performance review through their teaching and committee work. Group processes revealed strengths and limitations in groups' understanding of their work, leader role, and information-sharing procedures. Time pressure was a threat to the quality of group work. Conclusions Implications of the findings include the risks for committees that arise with homogeneous membership, limitations to available resident performance information, and processes that arise through experience rather than deriving from a well-articulated purpose of their work. Recommendations are presented to maximize the effectiveness of CCC processes, including their membership and access to, and interpretation of, information to yield evidence-based, well-reasoned judgments. PMID:27168881

  16. 77 FR 61581 - Notice of Advisory Committee Closed Meeting; U.S. Strategic Command Strategic Advisory Group

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-10

    .... Strategic Command Strategic Advisory Group AGENCY: Department of Defense. ACTION: Notice of Advisory... advisory committee: U.S. Strategic Command Strategic Advisory Group. DATES: November 15, 2012, from 8 a.m... Command, during the development of the Nation's strategic war plans. Agenda: Topics include: Policy Issues...

  17. 78 FR 67131 - Notice of Advisory Committee Closed Meeting; U.S. Strategic Command Strategic Advisory Group

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-08

    .... Strategic Command Strategic Advisory Group AGENCY: Department of Defense. ACTION: Notice of Advisory... following Federal Advisory Committee meeting of the U.S. Strategic Command Strategic Advisory Group. DATES... issues to the Commander, U.S. Strategic Command, during the development of the Nation's strategic war...

  18. Report on the BWR owners group radiation protection/ALARA Committee

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Aldrich, L.R.

    1995-03-01

    Radiation protection programs at U.S. boiling water reactor (BWR) stations have evolved during the 1980s and early 1990s from a regulatory adherence-based endeavor to a proactive, risk-based radiation protection and prevention mission. The objectives are no longer to merely monitor and document exposure to radiation and radioactive materials. The focus of the current programs is the optimization of radiation protection of occupational workers consistent with the purpose of producing cost-effective electric power. The newly revised 10 CFR 20 defines the term ALARA (as low as reasonably achievable) to take into account the state of technology, the economics of improvements inmore » relation to the state of the technology, and the benefits to the public health and safety. The BWR Owners Group (BWROG) initially formed the Radiation Protection/ALARA Committee in January 1990 to evaluate methods of reducing occupational radiation exposure during refueling outages. Currently, twenty U.S. BWR owner/operators (representing 36 of the operational 37 domestic BWR units), as well as three foreign BWR operators (associate members), have broadened the scope to promote information exchange between BWR radiation protection professionals and develop good practices which will affect optimization of their radiation protection programs. In search of excellence and the challenge of becoming {open_quotes}World Class{close_quotes} performers in radiation protection, the BWROG Radiation Protection/ALARA Committee has recently accepted a role in assisting the member utilities in improving radiation protection performance in a cost-effective manner. This paper will summarize the recent activities of this Committee undertaken to execute their role of exchanging information in pursuit of optimizing the improvement of their collective radiation protection performance.« less

  19. 77 FR 5801 - Consumer Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-06

    ... FEDERAL COMMUNICATIONS COMMISSION [DA 12-105] Consumer Advisory Committee AGENCY: Federal... agenda of its Consumer Advisory Committee (Committee). The purpose of the Committee is to make... the participation of all consumers in proceedings before the Commission. DATES: The next meeting of...

  20. The 12C/13C Isotopic Ratio In Titan's Hydrocarbons

    NASA Astrophysics Data System (ADS)

    Nixon, Conor A.; Achterberg, R. K.; Vinatier, S.; Bezard, B.; Coustenis, A.; Teanby, N. A.; Irwin, P. G.; Cassini CIRS Team

    2007-10-01

    Isotopic ratios in planetary atmospheres are of considerable interest, yielding insights both about currently occurring processes, and also the formation and early evolution of the body. Before Cassini, ground-based measurements of Titan's 12C/13C in HCN showed no firm evidence of deviation from the terrestrial inorganic standard (88.9) - albeit with large error bars of 20% - contrasting the enrichment in nitrogen (15N/14N≈4.5 terrestrial). Since 2004, the Composite Infrared Spectrometer (CIRS) instrument on Cassini has recorded spectra of Titan's stratosphere globally, including the emissions of multiple isotopologues for certain hydrocarbons. We selected spectra for analysis from four flybys (T4, T12, T19, T22), covering five latitudes from 65°S to 71°N. By means of a radiative transfer code and inversion scheme, we have first modeled the ν4 band of 12CH4 at 1304 cm-1 to retrieve stratospheric temperatures, and subsequently the emissions of 13CH4, 12C2H2, 13C12CH2, 12C2H6 and 13C12CH6. Our results indicate 12C/13C = 81.2±2.0 for all three species combined over all five latitudes, in excellent agreement with the Huygens GCMS value of 12CH4/13CH4 = 82.3±1.0 (Niemann et al. 2005), some 9% lower than terrestrial inorganic, and lower than in ethane on Saturn (91 (-13) (+26)) and Jupiter (99 (-23) (+43)) (Sada et al. 1996). No latitude variation was detected, however the 12C/13C in the C2 species (83.9±3.1 in acetylene, 89.9±7.2 in ethane) were consistently higher than in methane (78.0±2.7) after considering random errors. Although it is possible that this is a real chemical or physical (condensation) effect, it is more likely due to systematic errors in our temperature profile, as our spectra do not yield independent temperature information at 10 mbar where the emissions of 13C12CH2 and 13C12CH6 originate, and we default to the Huygens probe temperatures. In future, this problem may be resolved by modeling CIRS limb spectra.

  1. Dehydrogenation reactions of cyclic C(2)B(2)N(2)H(12) and C(4)BNH(12) isomers.

    PubMed

    Matus, Myrna H; Liu, Shih-Yuan; Dixon, David A

    2010-02-25

    The energetics for different dehydrogenation pathways of C(2)B(2)N(2)H(12) and C(4)BNH(12) cycles were calculated at the B3LYP/DGDZVP2 and G3(MP2) levels with additional calculations at the CCSD(T)/complete basis set level. The heats of formation of the different isomers were calculated from the G3(MP2) relative energies and the heats of formation of the most stable isomers of c-C(2)B(2)N(2)H(6), c-C(2)B(2)N(2)H(12), and c-C(4)BNH(12) at the CCSD(T)/CBS including additional corrections together with the previously reported value for c-C(4)BNH(6). Different isomers were analyzed for c-C(2)B(2)N(2)H(x) and c-C(4)BNH(x) (x = 6 and 12), and the most stable cyclic structures were those with C-C-B-N-B-N and C-C-C-C-B-N sequences, respectively. The energetics for the stepwise loss of three H(2) were predicted, and the most feasible thermodynamic pathways were found. Dehydrogenation of the lowest energy c-C(2)B(2)N(2)H(12) isomer (6-H(12)) is almost thermoneutral with DeltaH(3dehydro) = 3.4 kcal/mol at the CCSD(T)/CBS level and -0.6 kcal/mol at the G3(MP2) level at 298 K. Dehydrogenation of the lowest energy c-C(4)BNH(12) isomer (7-H(12)) is endothermic with DeltaH(3dehydro) = 27.9 kcal/mol at the CCSD(T)/CBS level and 23.5 kcal/mol at the G3(MP2) level at 298 K. Dehydrogenation across the B-N bond is more favorable as opposed to dehydrogenation across the B-C, N-C, and C-C bonds. Resonance stabilization energies in relation to that of benzene are reported as are NICS NMR chemical shifts for correlating with the potential aromatic character of the rings.

  2. Monitor unit calculations for external photon and electron beams: Report of the AAPM Therapy Physics Committee Task Group No. 71

    PubMed Central

    Gibbons, John P.; Antolak, John A.; Followill, David S.; Huq, M. Saiful; Klein, Eric E.; Lam, Kwok L.; Palta, Jatinder R.; Roback, Donald M.; Reid, Mark; Khan, Faiz M.

    2014-01-01

    A protocol is presented for the calculation of monitor units (MU) for photon and electron beams, delivered with and without beam modifiers, for constant source-surface distance (SSD) and source-axis distance (SAD) setups. This protocol was written by Task Group 71 of the Therapy Physics Committee of the American Association of Physicists in Medicine (AAPM) and has been formally approved by the AAPM for clinical use. The protocol defines the nomenclature for the dosimetric quantities used in these calculations, along with instructions for their determination and measurement. Calculations are made using the dose per MU under normalization conditions, \\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{upgreek} \\usepackage{mathrsfs} \\setlength{\\oddsidemargin}{-69pt} \\begin{document} }{}$D_0^\\prime $\\end{document}D0′, that is determined for each user's photon and electron beams. For electron beams, the depth of normalization is taken to be the depth of maximum dose along the central axis for the same field incident on a water phantom at the same SSD, where \\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{upgreek} \\usepackage{mathrsfs} \\setlength{\\oddsidemargin}{-69pt} \\begin{document} }{}$D_0^\\prime $\\end{document}D0′ = 1 cGy/MU. For photon beams, this task group recommends that a normalization depth of 10 cm be selected, where an energy-dependent \\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{upgreek} \\usepackage{mathrsfs} \\setlength{\\oddsidemargin}{-69pt} \\begin{document} }{}$D_0^\\prime $\\end{document}D0′ ≤ 1 cGy/MU is required. This recommendation differs from the more common approach of a normalization depth of dm, with

  3. 75 FR 8038 - Fruit and Vegetable Industry Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-23

    ... (FACA) (5 U.S.C. App. II), the Secretary of Agriculture established the Committee in August 2001 to..., commodity purchasing programs, and work group assignments and orientation for the new members. Those parties...

  4. The C-12/C-13 Ratio as a Chemistry Indicator

    NASA Technical Reports Server (NTRS)

    Wirstroem, Eva; Geppert, Wolf; Persson, Carina; Charnley, Steven

    2011-01-01

    Isotopic ratios of elements are considered powerful tools, e.g. in tracing the origin of solar system body materials, or the degree of nucleosynthesis processing throughout the Galaxy. In interstellar molecules, some isotopic ratios like H/D and C-12/C-13 can also be used as indicators of their chemical origin. Isotope fractionation in gas-phase chemical reactions and gas-dust interaction makes observations of the ratio between C-12 and C-13 isotopologues suitable to distinguish between different formation scenarios. We will present observations of the C-12/C-13 ratio in methanol and formaldehyde towards a sample of embedded, massive young stellar objects. In relation to this we also present results from theoretical modeling showing the usefulness of the C-12/C-13 ratio as a chemistry indicator.

  5. ASTM Committee C28: International Standards for Properties and Performance of Advanced Ceramics-Three Decades of High-Quality, Technically-Rigorous Normalization

    NASA Technical Reports Server (NTRS)

    Jenkins, Michael G.; Salem, Jonathan A.

    2016-01-01

    Physical and mechanical properties and performance of advanced ceramics and glasses are difficult to measure correctly without the proper techniques. For over three decades, ASTM Committee C28 on Advanced Ceramics, has developed high-quality, technically-rigorous, full-consensus standards (e.g., test methods, practices, guides, terminology) to measure properties and performance of monolithic and composite ceramics that may be applied to glasses in some cases. These standards contain testing particulars for many mechanical, physical, thermal, properties and performance of these materials. As a result these standards are used to generate accurate, reliable, repeatable and complete data. Within Committee C28, users, producers, researchers, designers, academicians, etc. have written, continually updated, and validated through round-robin test programs, 50 standards since the Committee's founding in 1986. This paper provides a detailed retrospective of the 30 years of ASTM Committee C28 including a graphical pictogram listing of C28 standards along with examples of the tangible benefits of standards for advanced ceramics to demonstrate their practical applications.

  6. ASTM Committee C28: International Standards for Properties and Performance of Advanced Ceramics, Three Decades of High-quality, Technically-rigorous Normalization

    NASA Technical Reports Server (NTRS)

    Jenkins, Michael G.; Salem, Jonathan A.

    2016-01-01

    Physical and mechanical properties and performance of advanced ceramics and glasses are difficult to measure correctly without the proper techniques. For over three decades, ASTM Committee C28 on Advanced Ceramics, has developed high quality, rigorous, full-consensus standards (e.g., test methods, practices, guides, terminology) to measure properties and performance of monolithic and composite ceramics that may be applied to glasses in some cases. These standards testing particulars for many mechanical, physical, thermal, properties and performance of these materials. As a result these standards provide accurate, reliable, repeatable and complete data. Within Committee C28 users, producers, researchers, designers, academicians, etc. have written, continually updated, and validated through round-robin test programs, nearly 50 standards since the Committees founding in 1986. This paper provides a retrospective review of the 30 years of ASTM Committee C28 including a graphical pictogram listing of C28 standards along with examples of the tangible benefits of advanced ceramics standards to demonstrate their practical applications.

  7. 78 FR 76177 - Meeting of the Judicial Conference Committee on Rules of Practice and Procedure

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-16

    ... Procedure. ACTION: Notice of open meeting. SUMMARY: The Committee on Rules of Practice and Procedure will hold a two-day meeting. The meeting will be open to public observation but not participation. DATES...: December 11, 2013. Jonathan C. Rose, Rules Committee Secretary. [FR Doc. 2013-29841 Filed 12-13-13; 8:45 am...

  8. COMMITTEES: Committees

    NASA Astrophysics Data System (ADS)

    2010-01-01

    TAUP STEERING COMMITTEE F T Avignone, University of South Carolina B C Barish, CALTECH E Bellotti, University of Milano, INFN J Bernabeu, University of Valencia A Bottino (Chair), University of Torino, INFN N Fornengo, University of Torino, INFN T Kajita, ICRR University of Tokyo C W Kim, Johns Hopkins University, KIAS V Matveev, INR Moscow J Morales, University of Zaragoza G Raffelt, MPI Munchen D Sinclair, University of Carleton M Spiro, IN2P3 TAUP 2009 INTERNATIONAL ADVISORY COMMITTEE J J Aubert, CNRS Marseille M Baldo-Ceolin, University of Padova, INFN G Bellini, University of Milano, INFN L Bergstrom, University of Stockholm R Bernabei, University of Roma Tor Vergata, INFN A Bettini, University of Padova, INFN, LSC S Bilenky, JINR Dubna D O Caldwell, UCSB J Cronin, University of Chicago A Dar, Technion Haifa G Domogatsky, INR Moscow J Ellis, CERN E Fernandez, IFAE Barcelona E Fiorini, University of Milano, INFN T Gaisser, University of Delaware G Gelmini, UCLA G Gerbier, CEA Saclay A Giazotto, INFN Pisa F Halzen, University of Wisconsin W Haxton, University of Washington T Kirsten MPI Heidelberg L Maiani, University of Roma La Sapienza, INFN A McDonald, Queen's University K Nakamura, KEK R Petronzio, INFN, University of Roma Tor Vergata L Resvanis, University of Athens F Ronga INFN, LNF C Rubbia INFN, LNGS A Smirnov, ICTP Trieste C Spiering, DESY N Spooner, University of Sheffield A Suzuki, KEK S Ting MIT, CERN M S Turner, FNAL, University of Chicago J W F Valle, IFIC Valencia D Vignaud, APC Paris G Zatsepin, INR Moscow TAUP 2009 ORGANIZING COMMITTEE R Aloisio, LNGS R Antolini, LNGS F Arneodo, LNGS Z Berezhiani, University of L'Aquila, INFN V Berezinsky, LNGS R Cerulli, LNGS E Coccia [Chair], LNGS/INFN, U of Roma Tor Vergata N D'Ambrosio, LNGS N Fornengo, University of Torino, INFN M Laubenstein, LNGS O Palamara, LNGS L Pandola [Scientific Secretary], LNGS

  9. 44 CFR 12.9 - Closed meetings.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Closed meetings. 12.9 Section... SECURITY GENERAL ADVISORY COMMITTEES § 12.9 Closed meetings. (a) The requirements of § 12.8 (c) and (d) of this part that meetings shall be open to the public and that the public shall be afforded an...

  10. Fatty acid composition of porcine cumulus oocyte complexes (COC) during maturation: effect of the lipid modulators trans-10, cis-12 conjugated linoleic acid (t10,c12 CLA) and forskolin.

    PubMed

    Prates, E G; Alves, S P; Marques, C C; Baptista, M C; Horta, A E M; Bessa, R J B; Pereira, R M

    2013-05-01

    The effect of maturation and of two lipid modulators supplementation along in vitro maturation (IVM) on fatty acid (FA) and dimethylacetal (DMA) composition of porcine cumulus oocyte complexes (COC) were studied. Abattoir-derived immature COC were analyzed for FA and DMA or submitted to IVM as follows: control group; t10,c12 CLA group, t10,c12 CLA supplementation for 44 h; Forskolin group, forskolin supplementation during the initial 2 h; t10,c12 CLA + forskolin group, t10,c12 CLA for 44 h and forskolin for just 2h. Each experimental group had five replicates. FA analysis of oocytes, cumulus cells (CC), follicular fluid, and culture media were performed by gas-liquid chromatography. Oocytes and their CC had different FA composition. Oocytes were richer in saturated FA (SFA) preferentially maintaining their FA profile during maturation. Mature CC had the highest polyunsaturated FA (PUFA) content. Five individual and total SFA, and monounsaturated FA (MUFA), notably oleic acid (c9-18:1), percentages were lower (P ≤ 0.023) in mature than in immature CC. t10,c12 CLA was accumulated by COC from t10,c12 CLA and t10,c12 CLA + forskolin groups, mostly in CC where MUFA and an eicosatrienoic isomer decreased (P ≤ 0.043). Nevertheless, PUFA or FA and DMA total content were not affected. Arachidonic acid was reduced in t10,c12 CLA + forskolin CC and hexadecanal-DMA-16:0 in t10,c12 CLA CC. Forskolin alone increased (P ≤ 0.043) c9-18:1 in oocytes. In conclusion, maturation process clearly changed porcine COC FA and DMA profiles, mostly of CC, also more susceptible to modifications induced by t10,c12 CLA. This possibility of manipulating COC lipid composition during IVM could be used to improve oocyte quality/cryopreservation efficiency.

  11. 78 FR 17924 - U.S. Strategic Command Strategic Advisory Group; Notice of Federal Advisory Committee Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-25

    ... DEPARTMENT OF DEFENSE Office of the Secretary U.S. Strategic Command Strategic Advisory Group... following federal advisory committee: U.S. Strategic Command Strategic Advisory Group. DATES: April 18, 2013..., intelligence, and policy-related issues to the Commander, U.S. Strategic Command, during the development of the...

  12. 77 FR 55863 - NASA Advisory Council; Science Committee; Earth Science Subcommittee; Applied Sciences Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-11

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (12-072)] NASA Advisory Council; Science Committee; Earth Science Subcommittee; Applied Sciences Advisory Group Meeting AGENCY: National Aeronautics... the Applied Science Advisory Group. This Subcommittee reports to the Earth Science Subcommittee...

  13. DFT and TD-DFT study of the adsorption and detection of sulfur mustard chemical warfare agent by the C24, C12Si12, Al12N12, Al12P12, Be12O12, B12N12 and Mg12O12 nanocages

    NASA Astrophysics Data System (ADS)

    Jouypazadeh, Hamidreza; Farrokhpour, Hossein

    2018-07-01

    In the present research, the interaction of sulfur mustard, a chemical warfare agent, with the surface of C24, C12Si12, Al12N12, Al12P12, Be12O12, B12N12 and Mg12O12 nanocages was studied using the dispersion corrected density function theory (DFT-D3) method. The calculated adsorption energies of sulfur mustard on the surface of the nanocages showed that the Al12N12, C12Si12 and Mg12O12 are useful for the adsorption of the sulfur mustard. The quantum theory atom in molecule (QTAIM) analysis was used to study the nature of interactions of sulfur mustard with the surface of the selected nanocages. Based on QTAIM analysis, the majority of interactions of sulfur and chlorine atoms of sulfur mustard with the surface of the considered nanocages are covalent and quasi covalent whereas the interactions of hydrogen atoms of sulfur mustard with the surface of the nanocages are generally non-covalent. The charge transfer between sulfur mustard and the nanocages as well as chemical quantum descriptors of complexes were calculated using natural bond orbital (NBO) method. The most electron charge transfers from the sulfur mustard to B12N12 nanocage where the S atom of sulfur mustard donor a chemical bond to B atom of the nanocage. The ability of the considered nanocages for detecting sulfur mustard was studied using time-dependent density function theory (TD-DFT) and density of state (DOS) diagram. It is found that the C24, Al12P12, Be12O12 and B12N12 nanocages are useful sensors for this chemical agent.

  14. 77 FR 74661 - Open Internet Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-17

    ... FEDERAL COMMUNICATIONS COMMISSION [DA 12-1986] Open Internet Advisory Committee AGENCY: Federal... agenda of the Open Internet Advisory Committee (Committee). The Committee was established to track and evaluate the effects of the Commission's Open Internet rules, and to provide any recommendations it deems...

  15. 77 FR 57086 - Open Internet Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-17

    ... FEDERAL COMMUNICATIONS COMMISSION [DA 12-1433] Open Internet Advisory Committee AGENCY: Federal... agenda of the Open Internet Advisory Committee (Committee). The Committee was established to track and evaluate the effects of the Commission's Open Internet rules, and to provide any recommendations it deems...

  16. Phase I Recommendations by the Air Quality Management Work Group to the Clean Air Act Advisory Committee

    EPA Pesticide Factsheets

    Recommendations to the Clean Air Act Advisory Committee by Air Quality Management Work Group addressing the recommendations made by the National Research Council to improve the U.S. air quality management system.

  17. 1α,25(OH)2-Vitamin D3 Inhibits C2C12 Cell Differentiation by Activating c-Src and ERK1/2.

    PubMed

    Wang, Zhonghua; Jiang, Aijun; Mei, Jingwei; Zhang, Xinyan

    2018-05-01

    The steroid hormone 1α,25(OH)2-vitamin D3 (1,25-D3) induced some biological responses through activation of MAPK cascades in various cell types. It seems that 1,25-D3 plays different roles at different stages of proliferating, differentiating, and differentiated C2C12 cells. We wanted to detect the effect of 1,25-D3 on myogenic differentiation and the role of ERK1/2 in differentiating stage induced by 2% horse serum with 1,25-D3. In this study, cells were induced to differentiate with 2% horse serum until the 7th day (with addition of 1,25-D3 every two days). The protein level of MHC (myosin heavy chain) and phosphorylation level of Src and ERK1/2 were determined with western blot. U0126 (MEK inhibitor) and PP2 (Src specific inhibitor) were used to confirm the relationship between 1,25-D3, MHC, Src, and ERK1/2. 1,25-D3 inhibited differentiation of C2C12 cells and fusion of myotubes by phosphorylating and activating Src and ERK1/2. Phosphorylation of ERK1/2 was inhibited, not only by U0126 but also by PP2 (a Src specific inhibitor) which led to the promotion of differentiation of C2C12 cells; however, U0126 did not inhibit Src phosphorylation. These results suggested that 1,25-D3 possibly inhibited C2C12 differentiation through Src and ERK1/2, and Src played an upstream role in this signaling pathway.

  18. Summary record of presentations to the Federal Telecommunication Standards Committee/Fiber optics task group

    NASA Astrophysics Data System (ADS)

    Hanson, A. G.

    1987-03-01

    The learning experience of a group of Federal-agency planners who face upgrading or augmenting existing on-premises communication systems and building wiring is documented. In July 1984, an interagency Fiber Optics Task Group was formed under the aegis of the Federal Telecommunication Standards Committee to study on-premises distribution systems, with emphasis on optical fiber implementation, sharing mutual problems and potential solutions for them. Chronological summary records of technical content of 11 Task Group meetings through September 1986 are summarized. Also condensed are the engineering presentations to the Task Group by industry on applicable state-of-the-art technology, including local area networks, private automatic branch exchanges, building wiring architecture, and optic fiber systems and components.

  19. Raman spectroscopy of isotopically pure ({sup 12}C, {sup 13}C) and isotopically mixed ({sup 12.5}C) diamond single crystals at ultrahigh pressures

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Enkovich, P. V., E-mail: enkovich@hppi.troitsk.ru; Brazhkin, V. V.; Lyapin, S. G.

    The Raman scattering by isotopically pure {sup 12}C and {sup 13}C diamond single crystals and by isotopically mixed {sup 12.5}C diamond single crystals is studied at a high accuracy. The studies are performed over a wide pressure range up to 73 GPa using helium as a hydrostatic pressure-transferring medium. It is found that the quantum effects, which determine the difference between the ratio of the Raman scattering frequencies in the {sup 12}C and {sup 13}C diamonds and the classical ratio (1.0408), increase to 30 GPa and then decrease. Thus, inversion in the sign of the quantum contribution to the physicalmore » properties of diamond during compression is detected. Our data suggest that the maximum possible difference between the bulk moduli of the {sup 12}C and {sup 13}C diamonds is 0.15%. The investigation of the isotopically mixed {sup 12.5}C diamond shows that the effective mass, which determines the Raman frequency, decreases during compression from 12.38 au at normal pressure to 12.33 au at 73 GPa.« less

  20. Bis-guanylhydrazone diimidazo[1,2-a:1,2-c]pyrimidine as a novel and specific G-quadruplex binding motif.

    PubMed

    Sparapani, Silvia; Bellini, Stefania; Gunaratnam, Mekala; Haider, Shozeb M; Andreani, Aldo; Rambaldi, Mirella; Locatelli, Alessandra; Morigi, Rita; Granaiola, Massimiliano; Varoli, Lucilla; Burnelli, Silvia; Leoni, Alberto; Neidle, Stephen

    2010-08-21

    A bis-guanylhydrazone derivative of diimidazo[1,2-a:1,2-c]pyrimidine has unexpectedly been found to be a potent stabiliser of several quadruplex DNAs, whereas there is no significant interaction with duplex DNA. Molecular modeling suggests that the guanylhydrazone groups play an active role in quadruplex binding.

  1. Quantum partner-dance in the 12C + 12C system yields sub-Coulomb fusion resonances

    NASA Astrophysics Data System (ADS)

    Diaz-Torres, Alexis; Wiescher, Michael

    2014-03-01

    A preliminary study of the 12C + 12C sub-Coulomb fusion reaction using the time-dependent wave-packet method is presented. The theoretical sub-Coulomb fusion resonances seem to correspond well with observations. The present method might be a more suitable tool for expanding the cross-section predictions towards lower energies than the commonly used potential-model approximation.

  2. Higher-Order-Mode Diagnostics and Suppression in Superconducting Cavities (HOMSC12)

    NASA Astrophysics Data System (ADS)

    Jones, Roger M.

    2014-01-01

    From the 25th of June through Wednesday lunchtime of the 27th of June 2012 the Cockcroft Institute and ASTeC hosted an ICFA supported mini workshop on Higher-Order-Mode Diagnostics and Suppression in Superconducting Cavities (HOMSC12). The local organizing committee for this international workshop was chaired by S. Buckley (ASTeC/STFC), conference administration by S. Waller (ASTeC/STFC), and the scientific program committee by R.M. Jones (Cockcroft Institute/University of Manchester).

  3. 78 FR 73143 - Negotiated Rulemaking Committee, Notice of Additional Committee Meeting-Title IV Federal Student...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-05

    ...On June 12, 2013, we announced our intention to establish a negotiated rulemaking committee to prepare proposed regulations to establish standards for programs that prepare students for gainful employment in a recognized occupation. We also announced the schedule for two sessions of committee meetings. We now announce the addition of a third session consisting of a one-day committee meeting.

  4. Joint Integration Office Independent Review Committee annual report, 1985

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    Comprised of seven persons with extensive experience in the issues of nuclear waste, the Independent Review Committee (IRC) provides independent and objective review of Defense Transuranic Waste Program (DTWP) activities managed by the Joint Integration Office (JIO), formerly the Defense Transuranic Waste Lead Organization (TLO). The Committee is ensured a broad, interdisciplinary perspective since its membership includes representatives from the fields of nuclear engineering, nuclear waste transportation, industrial quality control, systems and environmental engineering and state and local government. The scope of IRC activities includes overall review of specific TLO plans, projects and activities, and technical review of particular researchmore » and development projects. The Committee makes specific suggestions and recommendations based upon expertise in the field of TRU Waste Management. The IRC operates as a consulting group, under an independent charter providing objective review of program activities. This report summarizes the 12 major topics reviewed by the committee during 1985.« less

  5. 1 CFR 21.12 - Reservation of numbers.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 1 General Provisions 1 2014-01-01 2012-01-01 true Reservation of numbers. 21.12 Section 21.12 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER PREPARATION, TRANSMITTAL, AND... Reservation of numbers. In a case where related parts or related sections are grouped under a heading, numbers...

  6. 1 CFR 21.12 - Reservation of numbers.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Reservation of numbers. 21.12 Section 21.12 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER PREPARATION, TRANSMITTAL, AND... Reservation of numbers. In a case where related parts or related sections are grouped under a heading, numbers...

  7. 1 CFR 21.12 - Reservation of numbers.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 1 General Provisions 1 2012-01-01 2012-01-01 false Reservation of numbers. 21.12 Section 21.12 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER PREPARATION, TRANSMITTAL, AND... Reservation of numbers. In a case where related parts or related sections are grouped under a heading, numbers...

  8. 1 CFR 21.12 - Reservation of numbers.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 1 General Provisions 1 2013-01-01 2012-01-01 true Reservation of numbers. 21.12 Section 21.12 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER PREPARATION, TRANSMITTAL, AND... Reservation of numbers. In a case where related parts or related sections are grouped under a heading, numbers...

  9. YF-12C on ramp

    NASA Technical Reports Server (NTRS)

    1973-01-01

    The so-called YF-12C on the NASA Flight Research Center ramp. Following the loss of a YF-12A in a non-fatal accident in June 1971, NASA acquired the second production SR-71A (61-7951) from the Air Force. Because the SR-71 program was shrouded in the highest secrecy, the Air Force restricted NASA to using the aircraft solely for propulsion testing with YF-12A inlets and engines. It was designated the YF-12C, and given a bogus tail number (06937). The two YF-12As in the program had actual tail numbers 06935 and 06936. The first NASA flight of the YF-12C took place on 24 May 1972. The Flight Research Center's involvement with the YF-12A, an interceptor version of the Lockheed A-12, began in 1967. Ames Research Center was interested in using wind tunnel data that had been generated at Ames under extreme secrecy. Also, the Office of Advanced Research and Technology (OART) saw the YF-12A as a means to advance high-speed technology, which would help in designing the Supersonic Transport (SST). The Air Force needed technical assistance to get the latest reconnaissance version of the A-12 family, the SR-71A, fully operational. Eventually, the Air Force offered NASA the use of two YF-12A aircraft, 60-6935 and 606936. A joint NASA-USAF program was mapped out in June 1969. NASA and Air Force technicians spent three months readying 935 for flight. On 11 December 1969, the flight program got underway with a successful maiden flight piloted by Col. Joe Rogers and Maj. Gary Heidelbaugh of the SR-71/F-12 Test Force. During the program, the Air Force concentrated on military applications, and NASA pursued a loads research program. NASA studies included inflight heating, skin-friction cooling, 'coldwall' research (a heat transfer experiment), flowfield studies, shaker vane research, and tests in support of the Space Shuttle landing program. Ultimately, 935 became the workhorse of the program, with 146 flights between 11 December 1969 and 7 November 1979. The second YF-12A, 936, made

  10. 32 CFR 761.12 - Ships: Group authorizations.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 5 2011-07-01 2011-07-01 false Ships: Group authorizations. 761.12 Section 761... TRUST TERRITORY OF THE PACIFIC ISLANDS Entry Authorization § 761.12 Ships: Group authorizations. Ships or other craft in the following categories, except those ships which have been denied individual...

  11. 32 CFR 761.12 - Ships: Group authorizations.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 5 2012-07-01 2012-07-01 false Ships: Group authorizations. 761.12 Section 761... TRUST TERRITORY OF THE PACIFIC ISLANDS Entry Authorization § 761.12 Ships: Group authorizations. Ships or other craft in the following categories, except those ships which have been denied individual...

  12. 32 CFR 761.12 - Ships: Group authorizations.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 5 2013-07-01 2013-07-01 false Ships: Group authorizations. 761.12 Section 761... TRUST TERRITORY OF THE PACIFIC ISLANDS Entry Authorization § 761.12 Ships: Group authorizations. Ships or other craft in the following categories, except those ships which have been denied individual...

  13. 32 CFR 761.12 - Ships: Group authorizations.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 5 2014-07-01 2014-07-01 false Ships: Group authorizations. 761.12 Section 761... TRUST TERRITORY OF THE PACIFIC ISLANDS Entry Authorization § 761.12 Ships: Group authorizations. Ships or other craft in the following categories, except those ships which have been denied individual...

  14. Facile controlled synthesis of micro/nanostructure MCrO 4 (M = Ba, Pb) by using Gemini surfactant C 12-PEG-C 12 as a soft template

    NASA Astrophysics Data System (ADS)

    Chang, Wengui; Shen, Yuhua; Xie, Anjian; Liu, Xue

    2010-04-01

    Gemini surfactants, double sodium α-sulfonic polyethylene glycol laurate (abbreviated C 12-PEG-C 12), were prepared and applied as soft templates in the controlled synthesis of BaCrO 4 and PbCrO 4 micro/nanocrystals. The template effects were investigated by adjusting the length of the spacer, using PEG400 and PEG4000, of the Gemini surfactant. The results indicated that the size and morphology of BaCrO 4 and PbCrO 4 micro/nanocrystals varied with the change in spacer length of C 12-PEG-C 12, suggesting that the different lengths of the polyethylene glycol group spacers in the Gemini surfactants played a key role in determining the size and shape of the MCrO 4 micro/nanoparticles. The dynamic process of the formation of the novel morphology BaCrO 4 crystals showed that the morphology grew from a round-bar polyhedron, to regular polyhedron, to approximate octahedron to a uniform pistachio nut shape. The growth mechanism of the BaCrO 4 micro/nanocrystals was explained that C 12-PEG-C 12 had a greater interfacial adsorption and would effectively control the shape evolution during the crystal growth, while PbCrO 4 could be explained that the Gemini surfactants can undergo liquid-crystalline phase transitions with long channels providing a soft template effect and derived the nanorods formation. Room temperature fluorescence spectra were studied and these showed that the pistachio-shaped BaCrO 4 microcrystals and PbCrO 4 nanorods possess photoactive luminescence properties with emission peaks at 470 and 549 nm, respectively.

  15. 75 FR 69154 - Notice of Meeting of the National Parks Overflights Advisory Group Aviation Rulemaking Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-10

    ... Parks Air Tour Management Act of 2000 (NPATMA), enacted on April 5, 2000, as Public Law 106-181... Parks Overflights Advisory Group Aviation Rulemaking Committee ACTION: Notice of meeting. SUMMARY: The Federal Aviation Administration (FAA) and the National Park Service (NPS), in accordance with the National...

  16. 77 FR 12331 - Committee Management; Notice of Establishment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-29

    ... NATIONAL SCIENCE FOUNDATION Committee Management; Notice of Establishment The Director of the... consultation with the Committee Management Secretariat, General Services Administration. Name of Committee... Bolton, Committee Management Officer. [FR Doc. 2012-4758 Filed 2-28-12; 8:45 am] BILLING CODE 7555-01-P ...

  17. MEASUREMENT AND BASIC PHYSICS COMMITTEE OF THE U.S. CROSS-SECTION EVALUATION WORKING GROUP, ANNUAL REPORT 1997

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    SMITH,D.L.; MCLANE,V.

    1998-10-20

    The Cross-Section Evaluation Working Group (CSEWG) is a long-standing committee charged with responsibility for organizing and overseeing the US cross-section evaluation effort. Its main product is the official US evaluated nuclear data file, ENDF. The current version of this file is Version VI. All evaluations included in ENDF, as well as periodic modifications and updates to the file, are reviewed and approved by CSEWG and issued by the US Nuclear Data Center, Brookhaven National Laboratory. CSEWG is comprised of volunteers from the US nuclear data community who possess expertise in evaluation methodologies and who collectively have been responsible for producingmore » most of the evaluations included in ENDF. In 1992 CSEWG added the Measurements Committee to its list of standing committees and subcommittees. This action was based on a recognition of the importance of experimental data in the evaluation process as well as the realization that measurement activities in the US were declining at an alarming rate and needed considerable encouragement to avoid the loss of this resource. The mission of the Committee is to maintain contact with experimentalists in the US and to encourage them to contribute to the national nuclear data effort. Improved communication and the facilitation of collaborative activities are among the tools employed in achieving this objective. In 1994 the Committee was given an additional mission, namely, to serve as an interface between the applied interests represented in CSEWG and the basic nuclear science community. Accordingly, its name was changed to the Measurement and Basic Physics Committee. The present annual report is the third such document issued by the Committee. It contains voluntary contributions from several laboratories in the US. Their contributions were submitted to the Chairman for compilation and editing.« less

  18. 77 FR 5031 - Notice of a Meeting of a Working Group of the Advisory Committee to the Director

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-01

    ... the public about a meeting of the Advisory Committee to the Director (ACD) Working Group on Diversity in the Biomedical Research Workforce (WGBDRW). DATES: The meeting will be held on Tuesday, February...

  19. Human Space Flight Plans Committee

    NASA Image and Video Library

    2009-08-11

    Dr. Edward Crawley, Ford Professor of Engineering at MIT and co-chair, NASA Exploration Technology Development Program Review Committee speaks during the final meeting of the Human Space Flight Review Committee, Wednesday, Aug. 12, 2009, in Washington. Photo Credit: (NASA/Paul E. Alers)

  20. 75 FR 17953 - Native American Graves Protection and Repatriation Review Committee Findings Related to the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-08

    ... Repatriation Review Committee Findings Related to the Identity of Cultural Items in the Possession of the.... 3006(c)(3)), reviewed the record and made findings of fact related to the identity of 45 cultural items... Western Apache NAGPRA Working Group, to request from the Review Committee findings of fact on the identity...

  1. 76 FR 27743 - RTCA Program Management Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-12

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration RTCA Program Management Committee AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of RTCA Program Management Committee... Management Committee. DATES: The meeting will be held May 26, 2011 from 12 p.m. to 1 p.m. ADDRESSES: The...

  2. 75 FR 58367 - Technology Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-24

    ... COMMODITY FUTURES TRADING COMMISSION Technology Advisory Committee Meeting AGENCY: Commodity Futures Trading Commission (``CFTC''). ACTION: Notice of meeting of Technology Advisory Committee. SUMMARY: The Technology Advisory Committee will hold a public meeting on October 12, 2010, from 1 p.m. to 5 p.m...

  3. 11 CFR 9008.55 - Funding for convention committees, host committees and municipal funds.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... donations are in accordance with the requirements of 11 CFR 9008.52 and 9008.53. (b) Host committees and..., unless they satisfy the prerequisites of 11 CFR 300.2(b)(1). (c) Host committees and municipal funds are...

  4. 11 CFR 9008.55 - Funding for convention committees, host committees and municipal funds.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... donations are in accordance with the requirements of 11 CFR 9008.52 and 9008.53. (b) Host committees and..., unless they satisfy the prerequisites of 11 CFR 300.2(b)(1). (c) Host committees and municipal funds are...

  5. 11 CFR 9008.55 - Funding for convention committees, host committees and municipal funds.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... donations are in accordance with the requirements of 11 CFR 9008.52 and 9008.53. (b) Host committees and..., unless they satisfy the prerequisites of 11 CFR 300.2(b)(1). (c) Host committees and municipal funds are...

  6. 11 CFR 9008.55 - Funding for convention committees, host committees and municipal funds.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... donations are in accordance with the requirements of 11 CFR 9008.52 and 9008.53. (b) Host committees and..., unless they satisfy the prerequisites of 11 CFR 300.2(b)(1). (c) Host committees and municipal funds are...

  7. Methylcobalamin promotes proliferation and migration and inhibits apoptosis of C2C12 cells via the Erk1/2 signaling pathway

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Okamoto, Michio; Tanaka, Hiroyuki, E-mail: tanahiro-osk@umin.ac.jp; Okada, Kiyoshi

    2014-01-17

    Highlights: •Methylcobalamin activated the Erk1/2 signaling pathway in C2C12 cells. •Methylcobalamin promoted the proliferation and migration in C2C12 cells. •C2C12 cell apoptosis during differentiation was inhibited by methylcobalamin. -- Abstract: Methylcobalamin (MeCbl) is a vitamin B12 analog that has some positive effects on peripheral nervous disorders. Although some previous studies revealed the effects of MeCbl on neurons, its effect on the muscle, which is the final target of motoneuron axons, remains to be elucidated. This study aimed to determine the effect of MeCbl on the muscle. We found that MeCbl promoted the proliferation and migration of C2C12 myoblasts in vitromore » and that these effects are mediated by the Erk1/2 signaling pathway without affecting the activity of the Akt signaling pathway. We also demonstrated that MeCbl inhibits C2C12 cell apoptosis during differentiation. Our results suggest that MeCbl has beneficial effects on the muscle in vitro. MeCbl administration may provide a novel therapeutic approach for muscle injury or degenerating muscle after denervation.« less

  8. Human Space Flight Plans Committee

    NASA Image and Video Library

    2009-08-11

    Dr. Wanda Austin, president and CEO of the Aerospace Corp., left, asks a question during the final meeting of the Human Space Flight Review Committee, Wednesday, Aug. 12, 2009, in Washington as committee member Bohdan Bejmuk reviews his notes. Photo Credit: (NASA/Paul E. Alers)

  9. 7 CFR 407.12 - Group risk plan for cotton.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 6 2012-01-01 2012-01-01 false Group risk plan for cotton. 407.12 Section 407.12..., DEPARTMENT OF AGRICULTURE GROUP RISK PLAN OF INSURANCE REGULATIONS § 407.12 Group risk plan for cotton. The provisions of the Group Risk Plan for Cotton for the 2000 and succeeding crop years are as follows: 1...

  10. 7 CFR 407.12 - Group risk plan for cotton.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Group risk plan for cotton. 407.12 Section 407.12..., DEPARTMENT OF AGRICULTURE GROUP RISK PLAN OF INSURANCE REGULATIONS § 407.12 Group risk plan for cotton. The provisions of the Group Risk Plan for Cotton for the 2000 and succeeding crop years are as follows: 1...

  11. 7 CFR 407.12 - Group risk plan for cotton.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 6 2011-01-01 2011-01-01 false Group risk plan for cotton. 407.12 Section 407.12..., DEPARTMENT OF AGRICULTURE GROUP RISK PLAN OF INSURANCE REGULATIONS § 407.12 Group risk plan for cotton. The provisions of the Group Risk Plan for Cotton for the 2000 and succeeding crop years are as follows: 1...

  12. 7 CFR 407.12 - Group risk plan for cotton.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 6 2013-01-01 2013-01-01 false Group risk plan for cotton. 407.12 Section 407.12..., DEPARTMENT OF AGRICULTURE GROUP RISK PLAN OF INSURANCE REGULATIONS § 407.12 Group risk plan for cotton. The provisions of the Group Risk Plan for Cotton for the 2000 and succeeding crop years are as follows: 1...

  13. 76 FR 52642 - Notice of Advisory Committee Closed Meeting; U.S. Strategic Command Strategic Advisory Group

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-23

    ... DEPARTMENT OF DEFENSE Notice of Advisory Committee Closed Meeting; U.S. Strategic Command.... Strategic Command Strategic Advisory Group. DATES: November 1, 2011, from 8 a.m. to 5 p.m. and November 2..., intelligence, and policy-related issues to the Commander, U.S. Strategic Command, during the development of the...

  14. Minutes. Accredited Standards Committee on Noise, S12. U.S. Tag for ISO/ TC 43/S1 Noise and ISO/TC 94/SC12 Hearing Protection, Held in Denver, Colorado on 7 October 1993

    DTIC Science & Technology

    1993-10-07

    study at a special session sponsored by the Technical Committee on Noise, on Tuesday afternoon at the Denver, ASA. On Thursday of ASA week (October 7...COMMITTEE ON NOISE. S12 U.S. TAG FOR ISO/TC 43/SCI NOISE and ISO/TC 94/SC1 2 HEARING PP"OTECTION Denver, Colorado 7 October 1993 2As,,,MNUTES 94-03976 )4 2...r AVAIL BRENIG. D. P I, ’,I-pho’e (2? 2428 0373 STANDARDS MANAGER r,4 f’A, (2121 24A0146 S1 2/284 MINUTES OF S12 MEETING HELD IN DENVER, COLORADO, ON

  15. 77 FR 21979 - Notice of FERC Staff Attendance at the Entergy Regional State Committee Working Group and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-12

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Notice of FERC Staff Attendance at the Entergy Regional State Committee Working Group and Stakeholder Meeting The Federal Energy Regulatory Commission (Commission) hereby gives notice that members of its staff may attend the meeting noted below...

  16. 77 FR 47630 - Notice of FERC Staff Attendance at the Entergy Regional State Committee Working Group and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-09

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Notice of FERC Staff Attendance at the Entergy Regional State Committee Working Group and Stakeholder Meeting The Federal Energy Regulatory Commission (Commission) hereby gives notice that members of its staff may attend the meeting noted below...

  17. Interactions between ionic liquid surfactant [C12mim]Br and DNA in dilute brine.

    PubMed

    He, Yunfei; Shang, Yazhuo; Liu, Zhenhai; Shao, Shuang; Liu, Honglai; Hu, Ying

    2013-01-01

    Interactions between ionic liquid surfactant [C(12)mim]Br and DNA in dilute brine were investigated in terms of various experimental methods and molecular dynamics (MD) simulation. It was shown that the aggregation of [C(12)mim]Br on DNA chains is motivated not only by electrostatic attractions between DNA phosphate groups and [C(12)mim]Br headgroups but also by hydrophobic interactions among [C(12)mim]Br alkyl chains. Isothermal titration calorimetry analysis indicated that the [C(12)mim]Br aggregation in the presence and absence of DNA are both thermodynamically favored driven by enthalpy and entropy. DNA undergoes size transition and conformational change induced by [C(12)mim]Br, and the charges of DNA are neutralized by the added [C(12)mim]Br. Various microstructures were observed such as DNA with loose coil conformation in nature state, necklace-like structures, and compact spherical aggregates. MD simulation showed that the polyelectrolyte collapses upon the addition of oppositely charged surfactants and the aggregation of surfactants around the polyelectrolyte was reaffirmed. The simulation predicted the gradual neutralization of the negatively charged polyelectrolyte by the surfactant, consistent with the experimental results. Copyright © 2012 Elsevier B.V. All rights reserved.

  18. Committee Effectiveness in Higher Education: The Strengths and Weaknesses of Group Decision Making

    ERIC Educational Resources Information Center

    Bates, Stephen B.

    2014-01-01

    Focusing on five models of committee effectiveness for purposes of this assessment will lend insight into the strengths and weaknesses of utilizing a structured action plan as a guide to achieving and maintaining optimum committee effectiveness in higher education. In the compilation of the strengths and weaknesses of committee decision making,…

  19. 76 FR 67727 - Notice of FERC Staff Attendance at the Entergy Regional State Committee Work Group and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-02

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Notice of FERC Staff Attendance at the Entergy Regional State Committee Work Group and Stakeholder Meeting The Federal Energy Regulatory Commission hereby gives notice that members of its staff may attend the meeting noted below. Their attendance...

  20. 77 FR 3765 - Notice of FERC Staff Attendance at the Entergy Regional State Committee Work Group and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-25

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Notice of FERC Staff Attendance at the Entergy Regional State Committee Work Group and Stakeholder Meeting The Federal Energy Regulatory Commission hereby gives notice that members of its staff may attend the meeting noted below. Their attendance...

  1. 77 FR 15097 - Notice of FERC Staff Attendance at the Entergy Regional State Committee Working Group and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-14

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Notice of FERC Staff Attendance at the Entergy Regional State Committee Working Group and Stakeholders Meeting The Federal Energy Regulatory Commission hereby gives notice that members of its staff may attend the meeting noted below. Their attendance...

  2. 78 FR 50040 - Technology Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-16

    ... COMMODITY FUTURES TRADING COMMISSION Technology Advisory Committee AGENCY: Commodity Futures Trading Commission. ACTION: Notice of Meeting of Technology Advisory Committee. SUMMARY: The Commodity Futures Trading Commission (CFTC) announces that on September 12, 2013, the CFTC's Technology Advisory...

  3. SRS-sensor 13C/12C isotops measurements for detecting Helicobacter Pylori

    NASA Astrophysics Data System (ADS)

    Grishkanich, Aleksandr; Chubchenko, Yan; Elizarov, Valentin; Zhevlakov, Aleksandr; Konopelko, Leonid

    2018-02-01

    We developed SRS-sensor 13C/12C isotops measurements detecting Helicobacter Pylori for medical diagnostics of human health. Measuring of absolute 13C/12C isotope amount ratios allows to explore the topical problems of the modern world, alcoholic beverages and tobacco, medical diagnostics of human health. SRS method is used to measure the ratio of carbon isotopes in the exhaled carbon dioxide, which is used to diagnose the human infection of Helicobacter pylori and the influence of the Helicobacter pylori bacterium on the occurrence of gastritis, gastric and duodenal ulcers. A method for the analysis of human infection with Helicobacter pylori was developed on the basis of measurements of the ratio of 13C / 12C carbon isotopes in human exhaled air with a high level of measurement accuracy. The article reviews the work in the field of provision comparability of absolute 13C/12C isotope amount ratios in the environment and food. The analysis of the technical and metrological characteristics of traditional and perspective instruments for measuring isotope ratios is presented. The provision of comparability of absolute 13C/12C isotope amount ratios is carried by gravimetrically prepared reference standards. The key features and emerging issues are discussed.

  4. 12. 'Portal Strut for 1 208'101/2' C. to C. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. 'Portal Strut for 1 - 208'-10-1/2' C. to C. End Pins S. Tr. Thro. Skew Span, 6th Crossing of Sacramento River, So. Pac. Co., The Phoenix Bridge Co., C.O. 836D, Drawing No. 12, Scale - 1' = 1', Engineer - B.M. Krohn, May 22nd `01, J.C.S.' - Southern Pacific Railroad Shasta Route, Bridge No. 301.85, Milepost 301.85, Pollard Flat, Shasta County, CA

  5. CCCT - Patient Advocate Steering Committee

    Cancer.gov

    The Patient Advocate Steering Committee (PASC) works to ensure advocates involved with the Scientific Steering Committees (SSCs) are completely integrated in the development, implementation, and monitoring of clinical trials within those groups.

  6. β‐Taxilin participates in differentiation of C2C12 myoblasts into myotubes

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sakane, Hiroshi; Makiyama, Tomohiko; Nogami, Satoru

    Myogenesis is required for the development of skeletal muscle. Accumulating evidence indicates that the expression of several genes are upregulated during myogenesis and these genes play pivotal roles in myogenesis. However, the molecular mechanism underlying myogenesis is not fully understood. In this study, we found that β-taxilin, which is specifically expressed in the skeletal muscle and heart tissues, was progressively expressed during differentiation of C2C12 myoblasts into myotubes, prompting us to investigate the role of β-taxilin in myogenesis. In C2C12 cells, knockdown of β-taxilin impaired the fusion of myoblasts into myotubes, and decreased the diameter of myotubes. We also foundmore » that β-taxilin interacted with dysbindin, a coiled-coil-containing protein. Knockdown of dysbindin conversely promoted the fusion of myoblasts into myotubes and increased the diameter of myotubes in C2C12 cells. Furthermore, knockdown of dysbindin attenuated the inhibitory effect of β-taxilin depletion on myotube formation of C2C12 cells. These results demonstrate that β-taxilin participates in myogenesis through suppressing the function of dysbindin to inhibit the differentiation of C2C12 myoblasts into myotubes. - Highlights: • β‐Taxilin is progressively expressed during differentiation of C2C12 cell. • Knockdown of β-taxilin impaired C2C12 myotube formation. • β‐Taxilin interacted with dysbindin. • Knockdown of dysbindin promoted C2C12 myotube formation. • The function of β-taxilin in C2C12 myotube formation depends on dysbindin.« less

  7. Minutes: Annual Meeting of the President's Committee on Employment of the Handicapped (Washington, D.C., May 1-2, 1969).

    ERIC Educational Resources Information Center

    President's Committee on Employment of the Handicapped, Washington, DC.

    Reporting the events of the meeting of the President's Committee on Employment of the Handicapped, the text includes speeches by Chairman Russell, Senator Bob Dole, Secretary of Labor Schultz, Rene Carpenter, Mr. Lustenberger of the W.T. Grant Company, W.F. Schnitzler of the AFL-CIO, Mrs. Koontz of the Department of Labor, Dr. Harlem, President of…

  8. 77 FR 18814 - Emergency Access Advisory Committee; Announcement of Date of Next Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-28

    ... Communications and Video Accessibility Act (CVAA), Public Law 11-260, for the purpose of achieving equal access... those effective and efficient technologies and methods. Public Law 111-260 Sec. 106(c). During the... FEDERAL COMMUNICATIONS COMMISSION [DA 12-406] Emergency Access Advisory Committee; Announcement of...

  9. Addendum to Air Quality: Decision Support Tools, Partner Plans, Working Groups, Committees

    NASA Technical Reports Server (NTRS)

    Holekamp, Kara; Frisbie, Troy; Estep, Lee

    2005-01-01

    In the original report dated February 11, 2005, the utility of NASA Earth science data in the air quality activities of other agencies and organizations was assessed by reviewing strategic and mission plans and by conducting personal interviews with agency experts to identify and investigate agencies with the potential for partnership with NASA. The overarching agency strategic plans were reviewed and commonalities such as the desire for partnerships and technology development were noted. This addendum to the original report contains such information about the Tennessee Valley Authority and will be inserted as Section 2.6 of "Air Quality: Decision Support Tools, Partner Plans, Working Groups, Committees."

  10. Addendum to Air Quality: Decision Support Tools, Partner Plans, Working Groups, Committees

    NASA Technical Reports Server (NTRS)

    Holekamp, Kara; Frisbie, Troy; Estep, Lee

    2005-01-01

    In the original report dated February 11, 2005, the utility of the NASA Earth science data in the air quality activities of other agencies and organizations was assessed by reviewing strategic and mission plans and by conducting personal interviews with agency experts to identify and investigate agencies with the potential for partnership with NASA. The overarching agency strategic plans were reviewed and commonalities such as the desire for partnerships and technology development were noted. The addendum to the original report contains such information about the Tennessee Valley Authority and will be inserted in Section 2.6 of "Air Quality Decision Support Tools, Partner Plans, Working Groups, Committees".

  11. Patients Lacking a KIR-Ligand of HLA Group C1 or C2 Have a Better Outcome after Umbilical Cord Blood Transplantation.

    PubMed

    Martínez-Losada, Carmen; Martín, Carmen; Gonzalez, Rafael; Manzanares, Bárbara; García-Torres, Estefania; Herrera, Concha

    2017-01-01

    Donor natural killer (NK) cells can destroy residual leukemic cells after allogeneic hematopoietic stem cell transplantation. This effect is based on the interaction of killer-cell immunoglobulin-like receptors (KIR) of donor NK cells with ligands of the major histocompatibility complex found on the surface of the target cells. HLA-C1 subtypes provide the ligand for KIR2DL2 and KIR2DL3 and the HLA-C2 subtypes for KIR2DL1. We have studied the probability of relapse (PR) after single-unit unrelated cord blood transplantation (UCBT) in relation to the potential graft-vs.-leukemia effect mediated by NK cells present in the umbilical cord blood (UCB) by analyzing KIR-ligand and HLA-C typing of the receptor. Data from 33 consecutive patients given a single unit UCBT were included. We have considered two groups of patients based on the absence or the presence of one of the C-ligands for inhibitory KIR and the incompatibility HLA-C1/2 between UCB and patients. Group 1 ( n  = 21): the patient lacks a C-ligand for inhibitory KIR present in UCB NK cells, i.e., patients homozygous C1/C1 or C2/C2. Group 2 ( n  = 12): patients heterozygous C1/C2 in which KIR-mediated graft-vs.-leukemia effect is not expected (presence of both C ligands for inhibitory KIR in the receptor). With a median follow-up post-UCBT of 93 months, patients with absence of a C-ligand for inhibitory KIRs (Group 1) showed a lower actuarial PR than patients with both C-ligands (group 2): 21 ± 10 vs. 68 ± 18% at 2 year and 36 ± 13 vs. 84 ± 14% at 5 years ( p  = 0.025), respectively. In patients with acute lymphoblastic leukemia, the 2-year PR was 36 ± 21% for group 1 and 66 ± 26% for 2 ( p  = 0.038). Furthermore, group 1 had a lower incidence of grades II-IV acute graft-vs.-host disease ( p  = 0.04). In the setting of UCBT, the absence of a C-ligand (C1 or C2) of inhibitory KIR in the patient is associated with lower PR, which is probably due to the graft

  12. 75 FR 51473 - Houston/Galveston Navigation Safety Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-20

    ... Houston/Galveston Navigation Safety Advisory Committee (HOGANSAC) and its working groups will meet in... noon. The Committee's working groups will meet on September 9, 2010, from 9 a.m. to noon. These... materials distributed to each member of the Committee or working group should reach the Coast Guard on or...

  13. Ruminant Methane δ (13C/12C) - Values: Relation to Atmospheric Methane

    NASA Astrophysics Data System (ADS)

    Rust, Fleet

    1981-03-01

    The δ (13C/12C) - values of methane produced by fistulated steers, dairy cattle, and wethers, and dairy and beef cattle herds show a bimodal distribution that appears to be correlated with the plant type (C3 or C4, that is, producing either a three- or a four-carbon acid in the first step of photosynthesis) consumed by the animals. These results indicate that cattle and sheep, on a global basis, release methane with an average δ (13C/12C) value of -60 and -63 per mil, respectively. Together they are a source of atmospheric methane whose δ (13C/12C) is similar to published values for marsh gas and cannot explain the 20 per mil higher values for atmospheric methane.

  14. Theoretical prediction of novel ultrafine nanowires formed by Si12C12 cage-like clusters

    NASA Astrophysics Data System (ADS)

    Yong, Yongliang; Song, Bin; He, Pimo

    2014-02-01

    Using density functional theory calculations, we predict that novel SiC ultrafine nanowires can be produced via the coalescence of stable Si12C12 clusters. For the isolated Si12C12 clusters, we find that the cage-like structure with a distinct segregation between Si and C atoms is energetically more favourable than the fullerene-like structure with alternating Si-C bonds. Via the coalescence of Si12C12 clusters, three novel stable nanowires have been characterised. The band structure reveals that these nanowires are semiconductors with narrow gap, indicating that they may be used as infrared detectors and thermoelectrics.

  15. Ethane's 12C/13C Ratio in Titan: Implications for Methane Replenishment

    NASA Technical Reports Server (NTRS)

    Jennings, Donald E.; Nixon, C. A.; Romani, P. N.; Bjoraker, G. L.; Sada, P. V.; Lunsford, A. W.; Boyle, R. J.; Hesman, B. E.; McCabe, G. H.

    2009-01-01

    As the .main destination of carbon in the destruction of methane in the atmosphere of Titan, ethane provides information about the carbon isotopic composition of the reservoir from which methane is replenished. If the amount of methane entering the atmosphere is presently equal to the amount converted to ethane, the 12C/13C ratio in ethane should be close to the ratio in the reservoir. We have measured the 12C/13C ratio in ethane both with Cassini CIRS(exp 1) and from the ground and find that it is very close to the telluric standard and outer planet values (89), consistent with a primordial origin for the methane reservoir. The lower 12C/13C ratio measured for methane by Huygens GCMS (82.3) can be explained if the conversion of CH4 to CH3 (and C2H6) favors 12C over 13C with a carbon kinetic isotope effect of 1.08. The time required for the atmospheric methane to reach equilibrium, i.e., for replenishment to equal destruction, is approximately 5 methane atmospheric lifetimes.

  16. 76 FR 7882 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Digital I&C...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-11

    ... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Digital I&C Systems The ACRS Subcommittee on Digital Instrumentation & Control (DI&C) Systems will hold a meeting on February 23, 2011, Room T-2B3, 11545 Rockville Pike, Rockville, Maryland. The...

  17. 78 FR 65318 - National Committee on Vital and Health Statistics: Meeting Full Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-31

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Committee on Vital and Health Statistics: Meeting... Health Statistics (NCVHS), Full Committee Meeting. Time and Date: November 13, 2013 9:00 a.m.-2:15 p.m..., National Center for Health Statistics, 3311 Toledo Road, Auditorium B & C, Hyattsville, Maryland 20782...

  18. Reassessment of the 13C/12C and 14C/12C isotopic fractionation ratio and its impact on high-precision radiocarbon dating

    NASA Astrophysics Data System (ADS)

    Fahrni, Simon M.; Southon, John R.; Santos, Guaciara M.; Palstra, Sanne W. L.; Meijer, Harro A. J.; Xu, Xiaomei

    2017-09-01

    The vast majority of radiocarbon measurement results (14C/12C isotopic ratios or sample activities) are corrected for isotopic fractionation processes (measured as 13C/12C isotopic ratios) that occur in nature, in sample preparation and measurement. In 1954 Harmon Craig suggested a value of 2.0 for the fractionation ratio b that is used to correct 14C/12C ratios for shifts in the 13C/12C ratios and this value has been applied by the radiocarbon community ever since. While theoretical considerations suggest moderate deviations of b from 2.0, some measurements have suggested larger differences (e.g. b = 2.3, measured by Saliège and Fontes in 1984). With the high precision attained in radiocarbon measurements today (±2‰), even a relatively small deviation of b from 2.0 can impact the accuracy of radiocarbon data, and it is, therefore, of interest to re-evaluate the fractionation corrections. In the present study, the fractionation ratio b was determined by independent experiments on the chemical reduction of carbon dioxide (CO2) to elemental carbon (graphitization reaction) and on the photosynthetic uptake of CO2 by C3 and C4 plants. The results yielded b = 1.882 ± 0.019 for the reduction of CO2 to solid graphite and b = 1.953 ± 0.025 for the weighted mean of measurements involving C3 and C4 photosynthesis pathways. In addition, the analysis of over 9600 full-sized OX-I and OX-II normalizing standards measured between 2002 and 2012 confirms b values lower than 2.0. The obtained values are in good agreement with quantum mechanical estimates of the equilibrium fractionation and classic kinetic fractionation as well as with results from other light three-isotope systems (oxygen, magnesium, silicon and sulfur). While the value of the fractionation ratio varies with the relative importance of kinetic and equilibrium fractionation, the values obtained in the present study cluster around b = 1.9. Our findings suggest that a significant fraction of all samples

  19. Health Research Ethics Committees in South Africa 12 years into democracy

    PubMed Central

    Moodley, Keymanthri; Myer, Landon

    2007-01-01

    Background Despite the growth of biomedical research in South Africa, there are few insights into the operation of Research Ethics Committees (RECs) in this setting. We investigated the composition, operations and training needs of health RECs in South Africa against the backdrop of national and international guidelines. Methods The 12 major health RECs in South Africa were surveyed using semi-structured questionnaires that investigated the composition and functions of each REC as well as the operational issues facing committees. Results Health RECs in SA have an average of 16 members and REC members are predominantly male and white. Overall, there was a large discrepancy in findings between under-resourced RECs and well resourced RECs. The majority of members (56%) are scientists or clinicians who are typically affiliated to the same institution as the health REC. Community representatives account for only 8% of membership. Training needs for health REC members varied widely. Conclusion Most major health RECs in South Africa are well organized given the resource constraints that exist in relation to research ethics in developing countries. However, the gender, racial and occupational diversity of most of these RECs is suboptimal, and most RECs are not constituted in accordance with South African guidelines. Variability in the operations and training needs of RECs is a reflection of apartheid-entrenched influences in tertiary education in SA. While legislation now exists to enforce standardization of research ethics review systems, no provision has been made for resources or capacity development, especially to support historically-disadvantaged institutions. Perpetuation of this legacy of apartheid represents a violation of the principles of justice and equity. PMID:17254335

  20. Leptin rapidly activates PPARs in C2C12 muscle cells

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bendinelli, Paola; Piccoletti, Roberta; Maroni, Paola

    2005-07-08

    Experimental evidence suggests that leptin operates on the tissues, including skeletal muscle, also by modulating gene expression. Using electrophoretic mobility shift assays, we have shown that physiological doses of leptin promptly increase the binding of C2C12 cell nuclear extracts to peroxisome proliferator-activated receptor (PPAR) response elements in oligonucleotide probes and that all three PPAR isoforms participate in DNA-binding complexes. We pre-treated C2C12 cells with AACOCF{sub 3}, a specific inhibitor of cytosolic phospholipase A{sub 2} (cPLA{sub 2}), an enzyme that supplies ligands to PPARs, and found that it abrogates leptin-induced PPAR DNA-binding activity. Leptin treatment significantly increased cPLA{sub 2} activity, evaluatedmore » as the release of [{sup 3}H]arachidonic acid from pre-labelled C2C12 cells, as well as phosphorylation. Further, using MEK1 inhibitor PD-98059 we showed that leptin activates cPLA{sub 2} through ERK induction. These results support a direct effect of leptin on skeletal muscle cells, and suggest that the hormone may modulate muscle transcription also by precocious activation of PPARs through ERK-cPLA{sub 2} pathway.« less

  1. Are we there yet? A Practitioner's View of DO-178C/ED-12C

    NASA Astrophysics Data System (ADS)

    Daniels, Dewi

    RTCA DO-178B/EUROCAE ED-12B is the industry-accepted guidance for determining that the software aspects of airborne systems and equipment comply with airworthiness requirements. DO-178B/ED-12B, published in 1992, is being updated to DO-178C/ED-12C. Nearly six years in the making, DO- 178C/ED-12C is expected to be completed in December 2010. It will be accompanied by a new set of supplements providing additional and much-needed guidance on tool qualification, model based development and verification, objectoriented technologies, and formal methods. Written by a member of the DO-178C/ED-12C editorial team who is also a practising software developer and verifier, this paper provides a practitioner's view of the new standard and its supplements. It explains how they will affect your organisation, focusing on the practical implications of the many changes between DO-178B/ED-12B and DO-178C/ED-12C.

  2. 75 FR 33241 - Coconino Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-11

    ... DEPARTMENT OF AGRICULTURE Forest Service Coconino Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Coconino Resource Advisory Committee will meet in... 86341. Send written comments to Brady Smith, RAC Coordinator, Coconino Resource Advisory Committee, c/o...

  3. 75 FR 39656 - Coconino Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-12

    ... DEPARTMENT OF AGRICULTURE Forest Service Coconino Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Coconino Resource Advisory Committee will meet in... Brady Smith, RAC Coordinator, Coconino Resource Advisory Committee, c/o Forest Service, USDA, 1824 S...

  4. 50 CFR 600.117 - Council coordination committee (CCC).

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 12 2014-10-01 2014-10-01 false Council coordination committee (CCC). 600... Councils § 600.117 Council coordination committee (CCC). (a) The Councils may establish a Council coordination committee (CCC) consisting of the chairs, vice chairs, and executive directors of each of the...

  5. 50 CFR 600.117 - Council coordination committee (CCC).

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Council coordination committee (CCC). 600... Councils § 600.117 Council coordination committee (CCC). (a) The Councils may establish a Council coordination committee (CCC) consisting of the chairs, vice chairs, and executive directors of each of the...

  6. 50 CFR 600.117 - Council coordination committee (CCC).

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 12 2012-10-01 2012-10-01 false Council coordination committee (CCC). 600... Councils § 600.117 Council coordination committee (CCC). (a) The Councils may establish a Council coordination committee (CCC) consisting of the chairs, vice chairs, and executive directors of each of the...

  7. Enhancement of Palmarumycin C12 and C13 Production by the Endophytic Fungus Berkleasmium sp. Dzf12 in an Aqueous-Organic Solvent System.

    PubMed

    Mou, Yan; Xu, Dan; Mao, Ziling; Dong, Xuejiao; Lin, Fengke; Wang, Ali; Lai, Daowan; Zhou, Ligang; Xie, Bingyan

    2015-11-12

    The endophytic fungus Berkleasmium sp. Dzf12, isolated from Dioscorea zingiberensis, was found to produce palmarumycins C12 and C13 which possess a great variety of biological activities. Seven biocompatible water-immiscible organic solvents including n-dodecane, n-hexadecane, 1-hexadecene, liquid paraffin, dibutyl phthalate, butyl oleate and oleic acid were evaluated to improve palmarumycins C12 and C13 production in suspension culture of Berkleasmium sp. Dzf12. Among the chosen solvents both butyl oleate and liquid paraffin were the most effective to improve palmarumycins C12 and C13 production. The addition of dibutyl phthalate, butyl oleate and oleic acid to the cultures of Berkleasmium sp. Dzf12 significantly enhanced palmarumycin C12 production by adsorbing palmarumycin C12 into the organic phase. When butyl oleate was fed at 5% (v/v) in medium at the beginning of fermentation (day 0), the highest palmarumycin C12 yield (191.6 mg/L) was achieved, about a 34.87-fold increase in comparison with the control (5.3 mg/L). n-Dodecane, 1-hexadecene and liquid paraffin had a great influence on the production of palmarumycin C13. When liquid paraffin was added at 10% (v/v) in medium on day 3 of fermentation, the palmarumycin C13 yield reached a maximum value (134.1 mg/L), which was 4.35-fold that of the control (30.8 mg/L). Application of the aqueous-organic solvent system should be a simple and efficient process strategy for enhancing palmarumycin C12 and C13 production in liquid cultures of the endophytic fungus Berkleasmium sp. Dzf12.

  8. 77 FR 67688 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Digital I&C...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-13

    ... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Digital I&C; Notice of Meeting The ACRS Subcommittee on Digital I&C will hold a meeting on November 16, 2012, Room T-2B1, 11545 Rockville Pike, Rockville, Maryland. The entire meeting will be open...

  9. 76 FR 3081 - Sitka Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-19

    ... DEPARTMENT OF AGRICULTURE Forest Service Sitka Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Sitka Resource Advisory Committee will meet in Sitka...., Sitka, Alaska. Send written comments to Sitka Resource Advisory Committee, c/o District Ranger, USDA...

  10. 76 FR 85 - Coconino Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-03

    ... DEPARTMENT OF AGRICULTURE Forest Service Coconino Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Coconino Resource Advisory Committee will meet in... Resource Advisory Committee, c/o Forest Service, USDA, 1824 S. Thompson St., Flagstaff, Arizona 86001 or...

  11. 75 FR 65295 - Sitka Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-22

    ... DEPARTMENT OF AGRICULTURE Forest Service Sitka Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Sitka Resource Advisory Committee will meet in Sitka..., 204 Siginaka Way, Sitka, Alaska. Send written comments to Sitka Resource Advisory Committee, c/o...

  12. 12 CFR 271.3 - Published information.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Published information. 271.3 Section 271.3... AVAILABILITY OF INFORMATION § 271.3 Published information. (a) Federal Register. The Committee publishes in the... the actions, and the votes taken. (c) Other published information. From time to time, other...

  13. Proceedings of the IMOG (Interagency Manufacturing Operations Group) Numerical Systems Group. 62nd Meeting

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Maes, G.J.

    1993-10-01

    This document contains the proceedings of the 62nd Interagency Manufacturing Operations Group (IMOG) Numerical Systems Group. Included are the minutes of the 61st meeting and the agenda for the 62nd meeting. Presentations at the meeting are provided in the appendices to this document. Presentations were: 1992 NSG Annual Report to IMOG Steering Committee; Charter for the IMOG Numerical Systems Group; Y-12 Coordinate Measuring Machine Training Project; IBH NC Controller; Automatically Programmed Metrology Update; Certification of Anvil-5000 for Production Use at the Y-12 Plant; Accord Project; Sandia National Laboratories {open_quotes}Accord{close_quotes}; Demo/Anvil Tool Path Generation 5-Axis; Demo/Video Machine/Robot Animation Dynamics; Demo/Certification ofmore » Anvil Tool Path Generation; Tour of the M-60 Inspection Machine; Distributed Numerical Control Certification; Spline Usage Method; Y-12 NC Engineering Status; and Y-12 Manufacturing CAD Systems.« less

  14. Joint Funding Councils' Libraries Review Group (the "Follett") Report: The Contribution of the Information Technology Sub-Committee

    ERIC Educational Resources Information Center

    Brindley, Lynne J.

    2006-01-01

    Purpose: This article aims to look into a review of library provision in higher education, which was originally set up in 1992 by The Funding Councils of England, Scotland and Wales, and the Department of Education for Northern Ireland. Design/methodology/approach: The review group was structured into three sub-committees, under the umbrella of…

  15. Spectral temperatures of {Delta}{sup 0}(1232) resonances produced in p{sup 12}C and d{sup 12}C collisions at 4.2 GeV/c per nucleon

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Khan, Imran; Olimov, Kh. K., E-mail: olimov@comsats.edu.pk

    The reconstructed experimental transverse momentum (p{sub t}) distributions of {Delta}{sup 0}(1232) resonances produced in p{sup 12}C and d{sup 12}C collisions at 4.2 A GeV/c and the corresponding spectra calculated using Modified FRITIOF model were analyzed in the framework of Hagedorn Thermodynamic Model. The spectral temperatures of {Delta}{sup 0}(1232) resonances were extracted from fitting their p{sub t} spectra with one-temperature Hagedorn function. The extracted spectral temperatures of {Delta}{sup 0}(1232) were compared with the corresponding temperatures of {pi}{sup -} mesons in p{sup 12}C and d{sup 12}C collisions at 4.2 A GeV/c obtained similarly from fitting the p{sub t} spectra of {pi}{sup -}more » by one-temperature Hagedorn function. The spectral temperatures of {Delta}{sup 0}(1232) resonances agreed within uncertainties with the corresponding temperatures of {pi}{sup -} mesons produced in p{sup 12}C and d{sup 12}C collisions at 4.2 A GeV/c.« less

  16. 76 FR 2081 - Ketchikan Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-12

    ... Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Ketchikan Resource Advisory Committee will meet in Ketchikan, Alaska, March 29, 2011. The purpose of this meeting is... written comments to Ketchikan Resource Advisory Committee, c/o District Ranger, USDA Forest Service, 3031...

  17. Enhancement of C2C12 differentiation by perfluorocarbon-mediated oxygen delivery.

    PubMed

    Fujita, Hideaki; Shimizu, Kazunori; Morioka, Yuki; Nagamori, Eiji

    2010-09-01

    We have studied the effect of enhanced oxygen delivery by perfluorocarbons on the differentiation of C2C12 cells. The extent of differentiation was assessed by means of phase contrast/fluorescence microscopy, active tension measurement and the glucose consumption/lactate production rates. We found that enhanced oxygen delivery is suitable for full differentiation of C2C12 cells. Copyright 2010 The Society for Biotechnology, Japan. All rights reserved.

  18. Analysis and theoretical modeling of 18O enriched carbon dioxide spectrum by CRDS near 1.35 μm: (II) 16O13C18O, 16O13C17O, 12C18O2, 17O12C18O, 12C17O2, 13C18O2 and 17O13C18O

    NASA Astrophysics Data System (ADS)

    Karlovets, E. V.; Campargue, A.; Kassi, S.; Tashkun, S. A.; Perevalov, V. I.

    2017-04-01

    This contribution is the second part of the analysis of the room temperature absorption spectrum of 18O enriched carbon dioxide by very high sensitivity Cavity Ring Down spectroscopy between 6977 and 7918 cm-1 (1.43-1.26 μm). Overall, more than 8600 lines belonging to 166 bands of eleven carbon dioxide isotopologues were rovibrationnally assigned. In a first part (Kassi et al. J Quant Spectrosc Radiat Transfer 187 (2017) 414-425, http://dx.doi.org/10.1016/j.jqsrt.2016.09.002), the results relative to mono-substituted isotopologues, 16O12C18O, 16O12C17O, 12C16O2 and 13C16O2, were presented. This second contribution is devoted to the multiply-substituted isotopologues or clumped isotopologues of particular importance in geochemistry: 16O13C18O, 16O13C17O, 12C18O2, 17O12C18O, 12C17O2, 13C18O2 and 17O13C18O. On the basis of the predictions of effective Hamiltonian models, a total of 3195 transitions belonging to 73 bands were rovibrationnally assigned for these seven species. Among the 73 observed bands, 55 are newly reported. All the identified bands correspond to ΔP=10 and 11 series of transitions, where P= 2V1+V2+3V3 is the polyad number (Vi are vibrational quantum numbers). The accurate spectroscopic parameters of 70 bands have been determined from the standard band-by-band analysis. Global fits of the measured line intensities of the ΔP=10 series of transitions of 17O12C18O and 16O13C18O and of the ΔP=11 series of transitions of 12C18O2, 17O12C18O, 16O13C18O and 13C18O2 were performed to determine the corresponding sets of the effective dipole moment parameters.

  19. 78 FR 66865 - Negotiated Rulemaking Committee, Notice of Change to Schedule of Committee Meetings-Title IV...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-07

    ...On June 12, 2013, we announced our intention to establish a negotiated rulemaking committee to prepare proposed regulations to establish standards for programs that prepare students for gainful employment in a recognized occupation. We also announced the schedule for committee meetings. Because of the Federal Government shutdown due to a lapse in appropriations, we are rescheduling the second session of committee meetings to November 18-20, 2013. In addition, the last day of the second session will end at 5:00 p.m. instead of at noon.

  20. The 12C/13C Isotopic Ratio in Planetary Nebulae as Deduced from IUE Data

    NASA Astrophysics Data System (ADS)

    Miskey, C. L.; Feibelman, W. A.; Bruhweiler, F. C.

    2000-05-01

    The relative abundances of C, N, and O and the isotopic ratio of 12C/13C represent tracers of nucleosynthesis in intermediate stars with main-sequence masses between 0.6 and 8.0 solar masses in our Galaxy. Determining these abundances and the isotopic 12C/13C ratio in planetary nebulae (PNe) represent perhaps the best means to discern exactly how the ISM is enriched by CNO stellar nucleosynthesis. Walsh et al. (1996) and Clegg et al. (1997), using the Hubble Space Telescope, have derived the isotopic 12C/13C abundance ratio in the galactic carbon-rich PN, NGC 3918, and placed marginal constraints on it for the Magellanic PNe, N2 (SMC) and N122 (LMC). This was done using the well-known 12C 3P-1S (J=1-0 and J=2-0) transitions of C+2 at 1906.68 Angstroms and 1908.77 Angstroms and a J=0-0 transition at 1909.6 Angstroms, which is strictly forbidden in 12C. The finite nuclear spin of 13C (I=1/2) permits a corresponding F=1/2-1/2 electric dipole transition not seen in 12C. Since the 1909.6 Angstroms line is well separated from the other two 12C transitions, it provides an important means of determining 12C/13C in planetary nebulae. We have just completed a search of archival International Ultraviolet Explorer (IUE) high-dispersion spectra of approximately three dozen PNe, and derived 12C/13C ratios of 39 and 23 for the galactic PNe, NGC 2440 and NGC 6302, respectively. These are values much lower than the solar value of 89. In the other objects, the limited S/N of the IUE data indicate 12C/13C ratio upper limits much higher than 50. The implications of these results and their pertinence to stellar evolution are discussed.

  1. 12 CFR 611.325 - Bank and association nominating committees.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ....325 Section 611.325 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM ORGANIZATION Election of Directors and Other Voting Procedures § 611.325 Bank and association nominating committees... institution under § 611.320 and this section. (a) Composition. The voting stockholders of each bank and...

  2. Nanoparticle-mediated intracellular lipid accumulation during C2C12 cell differentiation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Tsukahara, Tamotsu, E-mail: ttamotsu@shinshu-u.ac.jp; Haniu, Hisao, E-mail: hhaniu@shinshu-u.ac.jp

    2011-03-25

    Research highlights: {yields} HTT2800 has a significant effect on intracellular lipid accumulation. {yields} HTT2800 reduced muscle-specific genes and led to the emergence of adipocyte-related genes. {yields} HT2800 converts the differentiation pathway of C2C12 myoblasts to that of adipoblast-like cells. -- Abstract: In this report, we sought to elucidate whether multiwall carbon nanotubes are involved in the modulation of the proliferation and differentiation of the skeletal muscle cell line C2C12. Skeletal muscle is a major mass peripheral tissue that accounts for 40% of total body weight and 50% of energy consumption. We focused on the differentiation pathway of myoblasts after exposuremore » to a vapor-grown carbon fiber, HTT2800, which is one of the most highly purified carbon nanotubes. This treatment leads in parallel to the expression of a typical adipose differentiation program. We found that HTT2800 stimulated intracellular lipid accumulation in C2C12 cells. We have also shown by quantified PCR analysis that the expression of adipose-related genes was markedly upregulated during HTT2800 exposure. Taken together, these results suggest that HTT2800 specifically converts the differentiation pathway of C2C12 myoblasts to that of adipoblast-like cells.« less

  3. 78 FR 20685 - Aviation Security Advisory Committee (ASAC) Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-05

    ... DEPARTMENT OF HOMELAND SECURITY Transportation Security Administration Aviation Security Advisory...; Notice of Closed Federal Advisory Committee Meeting. SUMMARY: The Aviation Security Advisory Committee... Committee Act, 5 U.S.C. App. (Pub. L. 92-463). The Aviation Security Advisory Committee (ASAC) provides...

  4. 77 FR 53920 - NASA Federal Advisory Committees

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-04

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice 12-070] NASA Federal Advisory Committees... by U.S. citizens for service on NASA Federal advisory committees. SUMMARY: In accordance with the...), Executive Office of the President, NASA announces its annual invitation for public nominations for service...

  5. Evaluation of IL-12RB1, IL-12B, CXCR-3 and IL-17a expression in cases affected by a non-healing form of cutaneous leishmaniasis: an observational study design.

    PubMed

    Moafi, Mohammad; Rezvan, Hossein; Sherkat, Roya; Taleban, Roya; Asilian, Ali; Zarkesh Esfahani, Seyed Hamid; Nilforoushzadeh, Mohammad Ali; Jaffary, Fariba; Feizi, Awat

    2017-01-27

    Seldom cutaneous leishmaniasis (CL) may present as a lasting and active lesion(s), known as a non-healing form of CL (NHCL). Non-functional type 1 T helper (Th1) cells are assumed the most important factor in the outcome of the disease. The present study aims to assess some molecular defects that potentially contribute to Th1 impairment in NHCL. This prospective observational study will be implemented among five groups. The first and second groups comprise patients afflicted with non-healing and healing forms of CL, respectively. The third group consists of those recovered participants who have scars as a result of CL. Those participants who have never lived or travelled to endemic areas of leishmaniasis will comprise the fourth group. The fifth group comprises participants living in hyperendemic areas for leishmaniasis, although none of them have been afflicted by CL. The aim is to recruit 10 NHCL cases and 30 participants in each of the other groups. A leishmanin skin test (LST) will be performed to assess in vivo immunity against the Leishmania infection. The cytokine profile (interleukin (IL)-12p70, interferon (IFN)-γ, C-X-C motif chemokine ligand (CXCL)-11 and IL-17a) of the isolated peripheral blood mononuclear cells (PBMCs) will be evaluated through ELISA. Real-time PCR will determine the C-X-C motif chemokine receptor (CXCR)-3 and IL-17a gene expression and expression of IL-12Rβ1 will be assessed by flow cytometry. Furthermore, IL-12B and IL-12RB1 mutation analysis will be performed. It is anticipated that the outcome of the current study will identify IL-12B and IL-12RB1 mutations, which lead to persistent lesions of CL. Furthermore, our expected results will reveal an association between NHCL and pro-inflammatory cytokines (IL-12p70, IFN-γ IL-17a and CXCL-11), as well as CXCR-3 expression. This study has been approved by a local ethical committee. The final results will be disseminated through peer-reviewed journals and scientific conferences

  6. 44 CFR 12.3 - Policy.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 44 Emergency Management and Assistance 1 2013-10-01 2013-10-01 false Policy. 12.3 Section 12.3 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY GENERAL ADVISORY COMMITTEES § 12.3 Policy. In determining whether an advisory committee should be created...

  7. 44 CFR 12.3 - Policy.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Policy. 12.3 Section 12.3 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY GENERAL ADVISORY COMMITTEES § 12.3 Policy. In determining whether an advisory committee should be created...

  8. 32 CFR 761.12 - Ships: Group authorizations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 5 2010-07-01 2010-07-01 false Ships: Group authorizations. 761.12 Section 761.12 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY ISLANDS UNDER NAVY JURISDICTION NAVAL DEFENSIVE SEA AREAS; NAVAL AIRSPACE RESERVATIONS, AREAS UNDER NAVY ADMINISTRATION, AND THE TRUST TERRITORY OF THE PACIFIC ISLANDS Entr...

  9. Conformational restriction through C alpha i <--> C alpha i cyclization: Ac12c, the largest cycloaliphatic C alpha,alpha- disubstituted glycine known.

    PubMed

    Saviano, M; Iacovino, R; Menchise, V; Benedetti, E; Bonora, G M; Gatos, M; Graci, L; Formaggio, F; Crisma, M; Toniolo, C

    2000-02-01

    Two complete series of N-protected, monodispersed oligopeptide esters to the pentamer level from 1-aminocyclododecane-1-carboxylic acid (Ac(12)c), an alpha-amino acid conformationally constrained through C(alpha)(i) <--> C(alpha)(i) cyclization, and either L-Ala or Aib residues, along with the N-protected Ac(12)c homopeptide alkylamide series from monomer to trimer, have been synthesized by solution methods and fully characterized. The solution-preferred conformations of these peptides have been assessed by Fourier transform ir absorption and (1)H-nmr techniques. Moreover, the molecular structures of one derivative (Z-Ac(12)c-OH) and three peptides [the tripeptide ester Z-L-Ala-Ac(12)c-L-Ala-OMe, the tripeptide alkylamide Z-(Ac(12)c)(3)-NHiPr, and the tetrapeptide ester Z-(Aib)(2)-Ac(12)c-Aib-OtBu (Aib, alpha-aminoisobutyric acid)] have been determined in the crystal state by x-ray diffraction. The results obtained point to the conclusion that beta-bends and 3(10)-helices are preferentially adopted by peptides based on Ac(12)c, the largest cycloaliphatic C-disubstituted glycine known. A comparison with the structural tendencies extracted from published works on peptides from Aib, the prototype of C-disubstituted glycines, and the other extensively studied members of the class of 1-aminocycloalkane-1-carboxylic acids (Ac(n) c, with n = 3-9), is made and the implications for the use of the Ac(12)c residue in the Ac(n) c scan approach of conformationally restricted analogues of bioactive peptides are briefly discussed. Copyright 2000 John Wiley & Sons, Inc.

  10. 76 FR 53169 - Advisory Committee on Disability Compensation; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-25

    ... DEPARTMENT OF VETERANS AFFAIRS Advisory Committee on Disability Compensation; Notice of Meeting... Committee Act) that the Advisory Committee on Disability Compensation will meet on September 12-13, 2011, at... maintenance and periodic readjustment of the VA Schedule for Rating Disabilities. The Committee is to assemble...

  11. 78 FR 69742 - Commercial Space Transportation Advisory Committee-Open Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-20

    ...Pursuant to Section 10(a)(2) of the Federal Advisory Committee Act (Pub. L. 92-463, 5 U.S.C. App. 2), notice is hereby given of a meeting of the Commercial Space Transportation Advisory Committee (COMSTAC). The meeting will take place on Tuesday, December 10, 2013, from 8:00 a.m. to 5:00 p.m., and Wednesday, December 11, from 8:30 a.m. to 2:00 p.m., at the National Housing Center, 1201 15th Street NW., Washington, DC 20005. This will be the 58th meeting of the COMSTAC. The proposed schedule for the COMSTAC working group meetings on December 10 is below:

  12. 75 FR 78777 - Advisory Committee On Reactor Safeguards; Renewal

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-16

    ... Committee includes individuals experienced in reactor operations, management; probabilistic risk assessment...: December 10, 2010. Andrew L. Bates, Advisory Committee Management Officer. [FR Doc. 2010-31590 Filed 12-15...

  13. The 12C/ 13C isotopic ratio in Titan hydrocarbons from Cassini/CIRS infrared spectra

    NASA Astrophysics Data System (ADS)

    Nixon, C. A.; Achterberg, R. K.; Vinatier, S.; Bézard, B.; Coustenis, A.; Irwin, P. G. J.; Teanby, N. A.; de Kok, R.; Romani, P. N.; Jennings, D. E.; Bjoraker, G. L.; Flasar, F. M.

    2008-06-01

    We have analyzed infrared spectra of Titan recorded by the Cassini Composite Infrared Spectrometer (CIRS) to measure the isotopic ratio 12C/ 13C in each of three chemical species in Titan's stratosphere: CH 4, C 2H 2 and C 2H 6. This is the first measurement of 12C/ 13C in any C 2 molecule on Titan, and the first measurement of 12CH 4/ 13CH 4 (non-deuterated) on Titan by remote sensing. Our spectra cover five widely-spaced latitudes, 65° S to 71° N and we have searched for both latitude variability of 12C/ 13C within a given species, and also for differences between the 12C/ 13C in the three gases. For CH 4 alone, we find C12/C13=76.6±2.7 (1- σ), essentially in agreement with the 12CH 4/ 13CH 4 measured by the Huygens Gas Chromatograph/Mass Spectrometer instrument (GCMS) [Niemann, H.B., and 17 colleagues, 2005. Nature 438, 779-784]: 82.3±1.0, and also with measured values in H 13CN and 13CH 3D by CIRS at lower precision [Bézard, B., Nixon, C., Kleiner, I., Jennings, D., 2007. Icarus 191, 397-400; Vinatier, S., Bézard, B., Nixon, C., 2007. Icarus 191, 712-721]. For the C 2 species, we find C12/C13=84.8±3.2 in C 2H 2 and 89.8±7.3 in C 2H 6, a possible trend of increasingly value with molecular mass, although these values are both compatible with the Huygens GCMS value to within error bars. There are no convincing trends in latitude. Combining all fifteen measurements, we obtain a value of C12/C13=80.8±2.0, also compatible with GCMS. Therefore, the evidence is mounting that 12C/ 13C is some 8% lower on Titan than on the Earth (88.9, inorganic standard), and lower than typical for the outer planets ( 88±7 [Sada, P.V., McCabe, G.H., Bjoraker, G.L., Jennings, D.E., Reuter, D.C., 1996. Astrophys. J. 472, 903-907]). There is no current model for this enrichment, and we discuss several mechanisms that may be at work.

  14. Organocatalytic Upgrading of Furfural and 5-Hydroxymethyl Furfural to C10 and C12 Furoins with Quantitative Yield and Atom-Efficiency

    PubMed Central

    Zang, Hongjun; Chen, Eugene Y. X.

    2015-01-01

    There is increasing interest in the upgrading of C5 furfural (FF) and C6 5-hydroxymethyl furfural (HMF) into C10 and C12 furoins as higher energy-density intermediates for renewable chemicals, materials, and biofuels. This work utilizes the organocatalytic approach, using the in situ generated N,S-heterocyclic carbene catalyst derived from thiazolium ionic liquids (ILs), to achieve highly efficient self-coupling reactions of FF and HMF. Specifically, variations of the thiazolium IL structure have led to the most active and efficient catalyst system of the current series, which is derived from a new thiazolium IL carrying the electron-donating acetate group at the 5-ring position. For FF coupling by this IL (0.1 mol %, 60 °C, 1 h), when combined with Et3N, furoin was obtained in >99% yield. A 97% yield of the C12 furoin was also achieved from the HMF coupling by this catalyst system (10 mol % loading, 120 °C, 3 h). On the other hand, the thiazolium IL bearing the electron-withdrawing group at the 5-ring position is the least active and efficient catalyst. The mechanistic aspects of the coupling reaction by the thiazolium catalyst system have also been examined and a mechanism has been proposed. PMID:25830482

  15. Organocatalytic upgrading of furfural and 5-hydroxymethyl furfural to C10 and C12 furoins with quantitative yield and atom-efficiency.

    PubMed

    Zang, Hongjun; Chen, Eugene Y X

    2015-03-30

    There is increasing interest in the upgrading of C5 furfural (FF) and C6 5-hydroxymethyl furfural (HMF) into C10 and C12 furoins as higher energy-density intermediates for renewable chemicals, materials, and biofuels. This work utilizes the organocatalytic approach, using the in situ generated N,S-heterocyclic carbene catalyst derived from thiazolium ionic liquids (ILs), to achieve highly efficient self-coupling reactions of FF and HMF. Specifically, variations of the thiazolium IL structure have led to the most active and efficient catalyst system of the current series, which is derived from a new thiazolium IL carrying the electron-donating acetate group at the 5-ring position. For FF coupling by this IL (0.1 mol %, 60 °C, 1 h), when combined with Et3N, furoin was obtained in >99% yield. A 97% yield of the C12 furoin was also achieved from the HMF coupling by this catalyst system (10 mol % loading, 120 °C, 3 h). On the other hand, the thiazolium IL bearing the electron-withdrawing group at the 5-ring position is the least active and efficient catalyst. The mechanistic aspects of the coupling reaction by the thiazolium catalyst system have also been examined and a mechanism has been proposed.

  16. Characterizing the astrophysical S factor for 12C+12C fusion with wave-packet dynamics

    NASA Astrophysics Data System (ADS)

    Diaz-Torres, Alexis; Wiescher, Michael

    2018-05-01

    A quantitative study of the astrophysically important subbarrier fusion of 12C+12C is presented. Low-energy collisions are described in the body-fixed reference frame using wave-packet dynamics within a nuclear molecular picture. A collective Hamiltonian drives the time propagation of the wave packet through the collective potential-energy landscape. The fusion imaginary potential for specific dinuclear configurations is crucial for understanding the appearance of resonances in the fusion cross section. The theoretical subbarrier fusion cross sections explain some observed resonant structures in the astrophysical S factor. These cross sections monotonically decline towards stellar energies. The structures in the data that are not explained are possibly due to cluster effects in the nuclear molecule, which need to be included in the present approach.

  17. 12 CFR 268.601 - EEO group statistics.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false EEO group statistics. 268.601 Section 268.601... RULES REGARDING EQUAL OPPORTUNITY Matters of General Applicability § 268.601 EEO group statistics. (a... solely statistical purpose for which the data is being collected, the need for accuracy, the Board's...

  18. Three-dimensional co-culture of C2C12/PC12 cells improves skeletal muscle tissue formation and function.

    PubMed

    Ostrovidov, Serge; Ahadian, Samad; Ramon-Azcon, Javier; Hosseini, Vahid; Fujie, Toshinori; Parthiban, S Prakash; Shiku, Hitoshi; Matsue, Tomokazu; Kaji, Hirokazu; Ramalingam, Murugan; Bae, Hojae; Khademhosseini, Ali

    2017-02-01

    Engineered muscle tissues demonstrate properties far from native muscle tissue. Therefore, fabrication of muscle tissues with enhanced functionalities is required to enable their use in various applications. To improve the formation of mature muscle tissues with higher functionalities, we co-cultured C2C12 myoblasts and PC12 neural cells. While alignment of the myoblasts was obtained by culturing the cells in micropatterned methacrylated gelatin (GelMA) hydrogels, we studied the effects of the neural cells (PC12) on the formation and maturation of muscle tissues. Myoblasts cultured in the presence of neural cells showed improved differentiation, with enhanced myotube formation. Myotube alignment, length and coverage area were increased. In addition, the mRNA expression of muscle differentiation markers (Myf-5, myogenin, Mefc2, MLP), muscle maturation markers (MHC-IId/x, MHC-IIa, MHC-IIb, MHC-pn, α-actinin, sarcomeric actinin) and the neuromuscular markers (AChE, AChR-ε) were also upregulated. All these observations were amplified after further muscle tissue maturation under electrical stimulation. Our data suggest a synergistic effect on the C2C12 differentiation induced by PC12 cells, which could be useful for creating improved muscle tissue. Copyright © 2014 John Wiley & Sons, Ltd. Copyright © 2014 John Wiley & Sons, Ltd.

  19. Multiplex pyrosequencing method to determine CYP2C9*3, VKORC1*2, and CYP4F2*3 polymorphisms simultaneously: its application to a Korean population and comparisons with other ethnic groups.

    PubMed

    Kim, Kyoung-Ah; Song, Wan-Geun; Lee, Hae-Mi; Joo, Hyun-Jin; Park, Ji-Young

    2014-11-01

    Warfarin is an anticoagulant that is difficult to administer because of the wide variation in dose requirements to achieve a therapeutic effect. CYP2C9, VKROC1, and CYP4F2 play important roles in warfarin metabolism, and their genetic polymorphisms are related to the variability in dose determination. In this study we describe a new multiplex pyrosequencing method to identify CYP2C9*3 (rs1057910), VKORC1*2 (rs9923231), and CYP4F2*3 (rs2108661) simultaneously. A multiplex pyrosequencing method to simultaneously detect CYP2C9*3, VKORC1*2, and CYP4F2*3 alleles was designed. We assessed the allele frequencies of the polymorphisms in 250 Korean subjects using the multiplex pyrosequencing method. The results showed 100 % concordance between single and multiplex pyrosequencing methods, and the polymorphisms identified by pyrosequencing were also validated with the direct sequencing method. The allele frequencies of these polymorphisms in this population were as follows: 0.040 for CYP2C9*3, 0.918 for VKORC1*2, and 0.416 for CYP4F2*3. Although the allele frequencies of the CYP2C9*3 and VKROC1*2 were comparable to those in Japanese and Chinese populations, their frequencies in this Korean population differed from those in other ethnic groups; the CYP4F2*3 frequency was the highest among other ethnic populations including Chinese and Japanese populations. The pyrosequencing methods developed were rapid and reliable for detecting CYP2C9*3, VKORC1*2, and CYP4F2*3. Large ethnic differences in the frequency of these genetic polymorphisms were noted among ethnic groups. CYP4F2*3 exhibited its highest allele frequency among other ethnic populations compared to that in a Korean population.

  20. Decision Making in Liver Transplant Selection Committees

    PubMed Central

    Volk, Michael L; Biggins, Scott W; Huang, Mary Ann; Argo, Curtis K; Fontana, Robert J; Anspach, Renee R

    2011-01-01

    Background In order to receive a liver transplant, patients must first be placed on the waiting list – a decision made in most transplant centers by a multidisciplinary committee. The function of these committees has never been studied. Objectives To describe decision making in liver transplant committees and identify opportunities for process improvement. Design Observational multi-center Setting We observed 63 meetings and interviewed 50 committee members at 4 liver transplant centers. Study Subjects Transplant committee members. Measurements Recorded transcripts and field notes were analyzed using standard qualitative sociological methods. Results While the structure of meetings varied by center, the process was uniform and involved reviewing possible reasons for patient exclusion using primarily inductive reasoning. Stated justifications for excluding patients were a) too well, b) non-hepatic comorbidities or advanced age, c) too sick in the setting of advanced liver disease, d) substance abuse, or e) other psychosocial barriers. Dominant themes identified included members’ angst over deciding who lives and dies, a high correlation between psychosocial barriers to transplant and patients’ socioeconomic status, and the influence of external forces on decision making. Consistently identified barriers to effective group decision making were: 1) unwritten center policies, and 2) confusion regarding advocacy versus stewardship roles. Limitations The use of qualitative methods provides broad understanding but limits specific inferences. These four centers may not be reflective of every transplant center nationwide. Conclusion The difficult decisions made by these committees are reasonably consistent and always well-intentioned, but might be improved by more explicit written policies and clarifying roles. This process may help inform resource allocation in other areas of medicine. Primary funding source The Greenwall Foundation. PMID:22007044

  1. Differentiation of Pigment in Eggs Using Carbon ((13)C/(12)C) and Nitrogen ((15)N/(14)N) Stable Isotopes.

    PubMed

    Sun, Feng M; Shi, Guang Y; Wang, Hui W

    2016-07-01

    Consumers prefer natural and healthy food, but artificial pigments are often abused in egg products. The study aimed at differentiating the origin of pigments in eggs by applying the technique of carbon ((13)C/(12)C) and nitrogen ((15)N/(14)N) stable isotope analysis. Five hundred sixty laying hens were randomly distributed into 14 treatments, which were divided into four groups: maize, carophyll red pigment, carophyll yellow pigment, and a mixture of carophyll red and yellow pigments. Eggs were collected and pretreated to determe the values of the Roche Yolk Color Fan (RCF), δ(13)C, and δ(15)N. With increasing maize content, the RCF and δ(13)C values of yolks increased. Moreover, the RCF values in the three pigment groups were significantly influenced by the artificial colors, but δ(13)C values were not significantly different, regardless of the existence of pigment. The δ(15)N values in all treatments did not vary as regularly as the carbon stable isotope. A strong positive correlation was found between RCF and δ(13)C in the maize group, but no such correlation was be observed in the pigment groups. It is concluded that carbon stable isotope ratio analysis (δ(13)C) of the yolk can be used to differentiate the origin of the pigment added to eggs.

  2. The first meeting of the Advisory Committee on the Future of the US Space Program (C-FUSSP)

    NASA Technical Reports Server (NTRS)

    1990-01-01

    These are minutes of the Advisory Committee on the Future of the U.S. Space Program (C-FUSSP). From September 13-15, 1990, presentations were made by the major leaders at NASA as well as industry leaders. The presentations draw on previous studies of the future of NASA space programs. Allowance was made for plenty of questions. The minutes reflect the views of governmental units such as the National Space Council, the NASA Administrators Office, Office of Space Science and Applications, Office of Space Flight, Office of Space Operations, Office of Aeronautics, Exploration, and Technology as well as other pertinent units and outside organizations. Members of the committee are listed at the conclusion of the minutes.

  3. Evaluation of IL-12RB1, IL-12B, CXCR-3 and IL-17a expression in cases affected by a non-healing form of cutaneous leishmaniasis: an observational study design

    PubMed Central

    Moafi, Mohammad; Rezvan, Hossein; Sherkat, Roya; Taleban, Roya; Asilian, Ali; Zarkesh Esfahani, Seyed Hamid; Nilforoushzadeh, Mohammad Ali; Jaffary, Fariba; Feizi, Awat

    2017-01-01

    Introduction Seldom cutaneous leishmaniasis (CL) may present as a lasting and active lesion(s), known as a non-healing form of CL (NHCL). Non-functional type 1 T helper (Th1) cells are assumed the most important factor in the outcome of the disease. The present study aims to assess some molecular defects that potentially contribute to Th1 impairment in NHCL. Methods and analysis This prospective observational study will be implemented among five groups. The first and second groups comprise patients afflicted with non-healing and healing forms of CL, respectively. The third group consists of those recovered participants who have scars as a result of CL. Those participants who have never lived or travelled to endemic areas of leishmaniasis will comprise the fourth group. The fifth group comprises participants living in hyperendemic areas for leishmaniasis, although none of them have been afflicted by CL. The aim is to recruit 10 NHCL cases and 30 participants in each of the other groups. A leishmanin skin test (LST) will be performed to assess in vivo immunity against the Leishmania infection. The cytokine profile (interleukin (IL)-12p70, interferon (IFN)-γ, C-X-C motif chemokine ligand (CXCL)-11 and IL-17a) of the isolated peripheral blood mononuclear cells (PBMCs) will be evaluated through ELISA. Real-time PCR will determine the C-X-C motif chemokine receptor (CXCR)-3 and IL-17a gene expression and expression of IL-12Rβ1 will be assessed by flow cytometry. Furthermore, IL-12B and IL-12RB1 mutation analysis will be performed. Discussion It is anticipated that the outcome of the current study will identify IL-12B and IL-12RB1 mutations, which lead to persistent lesions of CL. Furthermore, our expected results will reveal an association between NHCL and pro-inflammatory cytokines (IL-12p70, IFN-γ IL-17a and CXCL-11), as well as CXCR-3 expression. Ethics and dissemination This study has been approved by a local ethical committee. The final results will be

  4. Ledipasvir-Sofosbuvir for Treating Chronic Hepatitis C: A NICE Single Technology Appraisal-An Evidence Review Group Perspective.

    PubMed

    Thokala, P; Simpson, E L; Tappenden, P; Stevens, J W; Dickinson, K; Ryder, S; Harrison, P

    2016-08-01

    The National Institute for Health and Care Excellence (NICE) invited Gilead, the company manufacturing ledipasvir-sofosbuvir (LDV/SOF), to submit evidence for the clinical effectiveness and cost effectiveness of LDV/SOF for treating chronic hepatitis C. The School of Health and Related Research (ScHARR) Technology Assessment Group was commissioned as the Evidence Review Group (ERG). This paper describes the company's submission (CS), the ERG review and the subsequent decision of the NICE Appraisal Committee (AC). The ERG produced a critical review of the clinical effectiveness and cost-effectiveness evidence of LDV/SOF based upon the CS. The clinical effectiveness data for LDV/SOF were taken from ten trials: three phase III trials and seven phase II trials. Trials compared different durations of LDV/SOF, with and without ribavirin (RBV). There were no head-to-head trials comparing LDV/SOF with any comparator listed in the NICE scope. Data from the trials were mostly from populations with genotype 1 (GT1) disease, although some limited data were available for populations with genotypes 3 and 4. For GT1 treatment-naïve patients, sustained viral response for 12 weeks (SVR12) rates for LDV/SOF ranged from 93.1 to 99.4 % for subgroups of patients with non-cirrhotic disease, whilst SVR rates of 94.1 to 100 % were reported for subgroups of patients with compensated cirrhosis. For GT1 treatment-experienced patients, SVR12 rates ranging from 95.4 to 100 % were reported for subgroups of non-cirrhotic patients, and SVR rates ranging from 81.8 to 100 % were reported within subgroups of patients with compensated cirrhosis. Comparator data were not searched systematically as part of the submission, but were based on the company's previous NICE submission of sofosbuvir, with additional targeted searches. The ERG's critical appraisal of the company's economic evaluation highlighted a number of concerns. The ERG's base case analyses suggested that the incremental cost

  5. Theoretical investigation of stabilities and optical properties of Si12C12 clusters

    NASA Astrophysics Data System (ADS)

    Duan, Xiaofeng F.; Burggraf, Larry W.

    2015-01-01

    By sorting through hundreds of globally stable Si12C12 isomers using a potential surface search and using simulated annealing, we have identified low-energy structures. Unlike isomers knit together by Si-C bonds, the lowest energy isomers have segregated carbon and silicon regions that maximize stronger C-C bonding. Positing that charge separation between the carbon and silicon regions would produce interesting optical absorption in these cluster molecules, we used time-dependent density functional theory to compare the calculated optical properties of four isomers representing structural classes having different types of silicon and carbon segregation regions. Absorptions involving charge transfer between segregated carbon and silicon regions produce lower excitation energies than do structures having alternating Si-C bonding for which frontier orbital charge transfer is exclusively from separated carbon atoms to silicon atoms. The most stable Si12C12 isomer at temperatures below 1100 K is unique as regards its high symmetry and large optical oscillator strength in the visible blue. Its high-energy and low-energy visible transitions (1.15 eV and 2.56 eV) are nearly pure one-electron silicon-to-carbon transitions, while an intermediate energy transition (1.28 eV) is a nearly pure carbon-to-silicon one-electron charge transfer.

  6. YF-12C in flight at sunset

    NASA Technical Reports Server (NTRS)

    1974-01-01

    The so-called YF-12C in flight at sunset. The YF-12C was the second production SR-71A (61-7951), modified with YF-12A inlets and engines, and given a bogus tail number (06937). It replaced a YF-12A (60-6936) that crashed during a joint USAF-NASA research program. The Flight Research Center's involvement with the YF-12A, an interceptor version of the Lockheed A-12, began in 1967. Ames Research Center was interested in using wind tunnel data that had been generated at Ames under extreme secrecy. Also, the Office of Advanced Research and Technology (OART) saw the YF-12A as a means to advance high-speed technology, which would help in designing the Supersonic Transport (SST). The Air Force needed technical assistance to get the latest reconnaissance version of the A-12 family, the SR-71A, fully operational. Eventually, the Air Force offered NASA the use of two YF-12A aircraft, 60-6935 and 60-6936. A joint NASA-USAF program was mapped out in June 1969. NASA and Air Force technicians spent three months readying 935 for flight. On 11 December 1969, the flight program got underway with a successful maiden flight piloted by Col. Joe Rogers and Maj. Gary Heidelbaugh of the SR-71/F-12 Test Force. During the program, the Air Force concentrated on military applications, and NASA pursued a loads research program. NASA studies included inflight heating, skin-friction cooling, 'coldwall' research (a heat transfer experiment), flowfield studies, shaker vane research, and tests in support of the Space Shuttle landing program. Ultimately, 935 became the workhorse of the program, with 146 flights between 11 December 1969 and 7 November 1979. The second YF-12A, 936, made 62 flights. It was lost in a non-fatal crash on 24 June 1971. It was replaced by the YF-12C. The YF-12C was delivered to NASA on 16 July 1971. From then until 22 December 1978, it made 90 flights. The Lockheed A-12 family, known as the Blackbirds, were designed by Clarence 'Kelly' Johnson. They were constructed mostly

  7. 40 CFR 721.3025 - Fatty acids C12-18, C18 unsaturated, C12-18 alkyl esters (generic).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., C12-18 alkyl esters (generic). 721.3025 Section 721.3025 Protection of Environment ENVIRONMENTAL... communication program. A significant new use of these substances is any manner or method of manufacture, import, or processing associated with any use of these substances without providing risk notification as...

  8. 41 CFR 60-2.12 - Job group analysis.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 41 Public Contracts and Property Management 1 2013-07-01 2013-07-01 false Job group analysis. 60-2... 2-AFFIRMATIVE ACTION PROGRAMS Purpose and Contents of Affirmative Action Programs § 60-2.12 Job group analysis. (a) Purpose: A job group analysis is a method of combining job titles within the...

  9. 41 CFR 60-2.12 - Job group analysis.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 41 Public Contracts and Property Management 1 2012-07-01 2009-07-01 true Job group analysis. 60-2... 2-AFFIRMATIVE ACTION PROGRAMS Purpose and Contents of Affirmative Action Programs § 60-2.12 Job group analysis. (a) Purpose: A job group analysis is a method of combining job titles within the...

  10. 41 CFR 60-2.12 - Job group analysis.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 41 Public Contracts and Property Management 1 2014-07-01 2014-07-01 false Job group analysis. 60-2... 2-AFFIRMATIVE ACTION PROGRAMS Purpose and Contents of Affirmative Action Programs § 60-2.12 Job group analysis. (a) Purpose: A job group analysis is a method of combining job titles within the...

  11. The closo-Si{sub 12}C{sub 12} molecule from cluster to crystal: A theoretical prediction

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Duan, Xiaofeng F., E-mail: xiaofeng.duan@wpafb.af.mil, E-mail: larry.burggraf@us.af.mil; Air Force Institute of Technology, Wright-Patterson Air Force Base, Ohio 45433; Burggraf, Larry W., E-mail: xiaofeng.duan@wpafb.af.mil, E-mail: larry.burggraf@us.af.mil

    2016-03-21

    The structure of closo-Si{sub 12}C{sub 12} is unique among stable Si{sub n}C{sub m} isomers (n, m > 4) because of its high symmetry, π–π stacking of C{sub 6} rings and unsaturated silicon atoms at symmetrical peripheral positions. Dimerization potential surfaces reveal various dimerization reactions that form between two closo-Si{sub 12}C{sub 12} molecules through Si–Si bonds at unsaturated Si atoms. As a result the closo-Si{sub 12}C{sub 12} molecule is capable of polymerization to form stable 1D polymer chains, 2D crystal layers, and 3D crystals. 2D crystal structures formed by side-side polymerization satisfy eight Si valences on each monomer without large distortionmore » of the monomer structure. 3D crystals are formed by stacking 2D structures in the Z direction, preserving registry of C{sub 6} rings in monomer moiety.« less

  12. 7 CFR 780.10 - State committee appeals.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... adverse decision to NAD before requesting an appeal to the State Committee. (c) If a participant requests mediation or requests an appeal to NAD before a request for an appeal to the State Committee has been acted...

  13. 7 CFR 29.6127 - Stripper (C Group).

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 2 2014-01-01 2014-01-01 false Stripper (C Group). 29.6127 Section 29.6127... REGULATIONS TOBACCO INSPECTION Standards Grades § 29.6127 Stripper (C Group). This group consists of tobacco... Stripper. Heavy, ripe, firm, semielastic, normal strength and width, and 16 inches or over in length...

  14. 7 CFR 29.6127 - Stripper (C Group).

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 2 2012-01-01 2012-01-01 false Stripper (C Group). 29.6127 Section 29.6127... REGULATIONS TOBACCO INSPECTION Standards Grades § 29.6127 Stripper (C Group). This group consists of tobacco... Stripper. Heavy, ripe, firm, semielastic, normal strength and width, and 16 inches or over in length...

  15. 7 CFR 29.6127 - Stripper (C Group).

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Stripper (C Group). 29.6127 Section 29.6127... REGULATIONS TOBACCO INSPECTION Standards Grades § 29.6127 Stripper (C Group). This group consists of tobacco... Stripper. Heavy, ripe, firm, semielastic, normal strength and width, and 16 inches or over in length...

  16. 7 CFR 29.6127 - Stripper (C Group).

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 2 2013-01-01 2013-01-01 false Stripper (C Group). 29.6127 Section 29.6127... REGULATIONS TOBACCO INSPECTION Standards Grades § 29.6127 Stripper (C Group). This group consists of tobacco... Stripper. Heavy, ripe, firm, semielastic, normal strength and width, and 16 inches or over in length...

  17. 7 CFR 29.6127 - Stripper (C Group).

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 2 2011-01-01 2011-01-01 false Stripper (C Group). 29.6127 Section 29.6127... REGULATIONS TOBACCO INSPECTION Standards Grades § 29.6127 Stripper (C Group). This group consists of tobacco... Stripper. Heavy, ripe, firm, semielastic, normal strength and width, and 16 inches or over in length...

  18. 75 FR 8154 - Advisory Committee on Reactor Safeguards

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-23

    ... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards In accordance with the... on Reactor Safeguards (ACRS) will hold a meeting on March 4-6, 2010, 11545 Rockville Pike, Rockville....-12 p.m.: New Advanced Reactor Designs (Open)--The Committee will hear presentations by and hold...

  19. 29 CFR 14.3 - DOL Classification Review Committee.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 1 2014-07-01 2013-07-01 true DOL Classification Review Committee. 14.3 Section 14.3 Labor... Classification Review Committee. A DOL Classification Review Committee is hereby established. (a) Composition of... under the Freedom of Information Act, 5 U.S.C. 552, when a proposed denial is based on classification...

  20. DRAGON, a GPI-anchored membrane protein, inhibits BMP signaling in C2C12 myoblasts.

    PubMed

    Kanomata, Kazuhiro; Kokabu, Shoichiro; Nojima, Junya; Fukuda, Toru; Katagiri, Takenobu

    2009-06-01

    Bone morphogenetic proteins (BMPs) induce osteoblastic differentiation of myoblasts via binding to cell surface receptors. Repulsive guidance molecules (RGMs) have been identified as BMP co-receptors. We report here that DRAGON/RGMb, a member of the RGM family, suppressed BMP signaling in C2C12 myoblasts via a novel mechanism. All RGMs were expressed in C2C12 cells that were differentiated into myocytes and osteoblastic cells, but RGMc was not detected in immature cells. In C2C12 cells, only DRAGON suppressed ALP and Id1 promoter activities induced by BMP-4 or by constitutively activated BMP type I receptors. This inhibition by DRAGON was dependent on the secretory form of the von Willbrand factor type D domain. DRAGON even suppressed BMP signaling induced by constitutively activated Smad1. Over-expression of neogenin did not alter the inhibitory capacity of DRAGON. Taken together, these findings indicate that DRAGON may be an inhibitor of BMP signaling in C2C12 myoblasts. We also suggest that a novel molecule(s) expressed on the cell membrane may mediate the signal transduction of DRAGON in order to suppress BMP signaling in C2C12 myoblasts.

  1. 7 CFR 29.1164 - Cutters (C Group).

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... INSPECTION Standards Grades § 29.1164 Cutters (C Group). This group consists of leaves normally grown at or just below the midportion of the stalk. Leaves of the C group have a tendency to roll concealing the..., open leaf structure, medium body, oily, deep color intensity, spready, 20 inches or over in length...

  2. 7 CFR 29.1164 - Cutters (C Group).

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... INSPECTION Standards Grades § 29.1164 Cutters (C Group). This group consists of leaves normally grown at or just below the midportion of the stalk. Leaves of the C group have a tendency to roll concealing the..., open leaf structure, medium body, oily, deep color intensity, spready, 20 inches or over in length...

  3. 7 CFR 29.1164 - Cutters (C Group).

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... INSPECTION Standards Grades § 29.1164 Cutters (C Group). This group consists of leaves normally grown at or just below the midportion of the stalk. Leaves of the C group have a tendency to roll concealing the..., open leaf structure, medium body, oily, deep color intensity, spready, 20 inches or over in length...

  4. K-12th Grade Math and Science Education: The View from the Blackboard. Hearing Before the Committee on Science, House of Representatives, 107th Congress, First Session (March 7, 2001).

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. House.

    The hearing reported in this document focuses on mathematics and science education at the K-12 grade levels. The hearing includes the opening statements of Representative Sherwood Boehlert, Chairman, Committee on Science, U.S. House of Representatives and Representative Ralph Hall, Ranking Minority Member, Committee on Science, U.S. House of…

  5. Ruminant methane delta(/sup 13/C//sup 12/C) values: relation to atmospheric methane

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Rust, F.

    1981-03-06

    The delta(/sup 13/C//sup 12/C) - values of methane produced by fistulated steers, dairy cattle, and wethers, and dairy and beef cattle herds show a bimodal distribution that appears to be correlated with the plant type (C/sub 3/ or C/sub 4/, that is, producing either a three- or a four-carbon acid in the first step of photosynthesis) consumed by the animals. These results indicate that cattle and sheep, on a global basis, release methane with an average delta(/sup 13/C//sup 12/C) value of -60 and -63 per mil, respectively. Together they are a source of atmospheric methane whose delta(/sup 13/C//sup 12/C) ismore » similar to published values for marsh gas and cannot explain the 20 per mil higher values for atmospheric methane.« less

  6. 77 FR 4238 - Advisory Committee Management

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-27

    ... DEPARTMENT OF STATE 22 CFR Part 8 RIN 1400-AC64 [Public Notice 7773] Advisory Committee Management.... Appendix, agency heads are required to establish uniform administrative guidelines and management controls... Committee Management. Accordingly, under the authority of 22 U.S.C. 2651a, for the reasons set forth in the...

  7. C-12/C-13 Ratio in Ethane on Titan and Implications for Methane's Replenishment

    NASA Technical Reports Server (NTRS)

    Jennings, Donald E.; Romani, Paul N.; Bjoraker, Gordon L.; Sada, Pedro V.; Nixon, Conor A.; Lunsford, Allen W.; Boyle, Robert J.; Hesman, Brigette E.; McCabe, George H.

    2009-01-01

    The C-12/C-13 abundance ratio in ethane in the atmosphere of Titan has been measured at 822 cm(sup -1) from high spectral resolution ground-based observations. The value 89(8), coincides with the telluric standard and also agrees with the ratio seen in the outer planets. It is almost identical to the result for ethane on Titan found by the composite infrared spectrometer (CIRS) on Cassini. The C-12/C-13 ratio for ethane is higher than the ratio measured in atmospheric methane by Cassini/Huygens GCMS, 82.3(l), representing an enrichment of C-12 in the ethane that might be explained by a kinetic isotope effect of approximately 1.1 in the formation of methyl radicals. If methane is being continuously resupplied to balance photochemical destruction, then we expect the isotopic composition in the ethane product to equilibrate at close to the same C-12/C-13 ratio as that in the supply. The telluric value of the ratio in ethane then implies that the methane reservoir is primordial.

  8. 77 FR 5578 - Founding Fathers Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-03

    ... NATIONAL ARCHIVES AND RECORDS ADMINISTRATION Founding Fathers Advisory Committee AGENCY: National Archives and Records Administration. ACTION: Notice of meeting. SUMMARY: In accordance with the Federal Advisory Committee Act, as amended (5 U.S.C. Appendix 2), and the Presidential Historical Records...

  9. First Steps with a Library Advisory Committee

    ERIC Educational Resources Information Center

    Pickett, Janie

    2013-01-01

    Implementing a library advisory committee (LAC) is one of those fundamentals taught in the Master of Library Science program: gather shareholders, create consensus, and build a community. But the day-to-day reality of K-12 schools often is not conducive to vision building, and if there is no administrator support for such a committee, faculty and…

  10. Directing-Group-mediated C-H-Alkynylations.

    PubMed

    Caspers, Lucien D; Nachtsheim, Boris J

    2018-05-18

    C-C triple bonds are amongst the most versatile functional groups in synthetic chemistry. Complementary to the Sonogashira coupling the direct metal-catalyzed alkynylation of C-H bonds has emerged as a highly promising approach in recent years. To guarantee a high regioselectivity suitable directing groups (DGs) are necessary to guide the transition metal (TM) into the right place. In this Focus Review we present the current developments in DG-mediated C(sp 2 )-H and C(sp 3 )-H modifications with terminal alkynes under oxidative conditions and with electrophilic alkynylation reagents. We will discuss further modifications of the alkyne, in particular subsequent cyclizations to carbo- and heterocycles and modifications of the DG in the presence of the alkyne. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  11. 11 CFR 105.1 - Place of filing; House candidates and their authorized committees (2 U.S.C. 432(g)(1)).

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 11 Federal Elections 1 2010-01-01 2010-01-01 false Place of filing; House candidates and their authorized committees (2 U.S.C. 432(g)(1)). 105.1 Section 105.1 Federal Elections FEDERAL ELECTION COMMISSION GENERAL DOCUMENT FILING (2 U.S.C. 432(g)) § 105.1 Place of filing; House candidates and their authorized...

  12. 11 CFR 105.1 - Place of filing; House candidates and their authorized committees (2 U.S.C. 432(g)(1)).

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 11 Federal Elections 1 2011-01-01 2011-01-01 false Place of filing; House candidates and their authorized committees (2 U.S.C. 432(g)(1)). 105.1 Section 105.1 Federal Elections FEDERAL ELECTION COMMISSION GENERAL DOCUMENT FILING (2 U.S.C. 432(g)) § 105.1 Place of filing; House candidates and their authorized...

  13. Human Space Flight Plans Committee

    NASA Image and Video Library

    2009-08-11

    Norman Augustine, chair, listens to a speaker's presentation during the final meeting of the Human Space Flight Review Committee, Wednesday, Aug. 12, 2009, in Washington. Photo Credit: (NASA/Paul E. Alers)

  14. 40 CFR 180.1284 - Ammonium salts of higher fatty acids (C8-C18 saturated; C8-C12 unsaturated); exemption from the...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Ammonium salts of higher fatty acids... Ammonium salts of higher fatty acids (C8-C18 saturated; C8-C12 unsaturated); exemption from the requirement of a tolerance. Ammonium salts of C8-C18 saturated and C8-C12 unsaturated higher fatty acids are...

  15. 40 CFR 180.1284 - Ammonium salts of higher fatty acids (C8-C18 saturated; C8-C12 unsaturated); exemption from the...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 24 2011-07-01 2011-07-01 false Ammonium salts of higher fatty acids... Ammonium salts of higher fatty acids (C8-C18 saturated; C8-C12 unsaturated); exemption from the requirement of a tolerance. Ammonium salts of C8-C18 saturated and C8-C12 unsaturated higher fatty acids are...

  16. Biosphere model simulations of interannual variability in terrestrial 13C/12C exchange

    NASA Astrophysics Data System (ADS)

    van der Velde, I. R.; Miller, J. B.; Schaefer, K.; Masarie, K. A.; Denning, S.; White, J. W. C.; Tans, P. P.; Krol, M. C.; Peters, W.

    2013-09-01

    Previous studies suggest that a large part of the variability in the atmospheric ratio of 13CO2/12CO2originates from carbon exchange with the terrestrial biosphere rather than with the oceans. Since this variability is used to quantitatively partition the total carbon sink, we here investigate the contribution of interannual variability (IAV) in biospheric exchange to the observed atmospheric 13C variations. We use the Simple Biosphere - Carnegie-Ames-Stanford Approach biogeochemical model, including a detailed isotopic fractionation scheme, separate 12C and 13C biogeochemical pools, and satellite-observed fire disturbances. This model of 12CO2 and 13CO2 thus also produces return fluxes of 13CO2from its differently aged pools, contributing to the so-called disequilibrium flux. Our simulated terrestrial 13C budget closely resembles previously published model results for plant discrimination and disequilibrium fluxes and similarly suggests that variations in C3 discrimination and year-to-year variations in C3and C4 productivity are the main drivers of their IAV. But the year-to-year variability in the isotopic disequilibrium flux is much lower (1σ=±1.5 PgC ‰ yr-1) than required (±12.5 PgC ‰ yr-1) to match atmospheric observations, under the common assumption of low variability in net ocean CO2 fluxes. This contrasts with earlier published results. It is currently unclear how to increase IAV in these drivers suggesting that SiBCASA still misses processes that enhance variability in plant discrimination and relative C3/C4productivity. Alternatively, 13C budget terms other than terrestrial disequilibrium fluxes, including possibly the atmospheric growth rate, must have significantly different IAV in order to close the atmospheric 13C budget on a year-to-year basis.

  17. IGF-1 prevents simvastatin-induced myotoxicity in C2C12 myotubes.

    PubMed

    Bonifacio, Annalisa; Sanvee, Gerda M; Brecht, Karin; Kratschmar, Denise V; Odermatt, Alex; Bouitbir, Jamal; Krähenbühl, Stephan

    2017-05-01

    Statins are generally well tolerated, but treatment with these drugs may be associated with myopathy. The mechanisms of statin-associated myopathy are not completely understood. Statins inhibit AKT phosphorylation by an unclear mechanism, whereas insulin-like growth factor (IGF-1) activates the IGF-1/AKT signaling pathway and promotes muscle growth. The aims of the study were to investigate mechanisms of impaired AKT phosphorylation by simvastatin and to assess effects of IGF-1 on simvastatin-induced myotoxicity in C2C12 myotubes. C2C12 mouse myotubes were exposed to 10 μM simvastatin and/or 10 ng/mL IGF-1 for 18 h. Simvastatin inhibited the IGF-1/AKT signaling pathway, resulting in increased breakdown of myofibrillar proteins, impaired protein synthesis and increased apoptosis. Simvastatin inhibited AKT S473 phosphorylation, indicating reduced activity of mTORC2. In addition, simvastatin impaired stimulation of AKT T308 phosphorylation by IGF-1, indicating reduced activation of the IGF-1R/PI3K pathway by IGF-1. Nevertheless, simvastatin-induced myotoxicity could be at least partially prevented by IGF-1. The protective effects of IGF-1 were mediated by activation of the IGF-1R/AKT signaling cascade. Treatment with IGF-1 also suppressed muscle atrophy markers, restored protein synthesis and inhibited apoptosis. These results were confirmed by normalization of myotube morphology and protein content of C2C12 cells exposed to simvastatin and treated with IGF-1. In conclusion, impaired activity of AKT can be explained by reduced function of mTORC2 and of the IGF-1R/PI3K pathway. IGF-1 can prevent simvastatin-associated cytotoxicity and metabolic effects on C2C12 cells. The study gives insight into mechanisms of simvastatin-associated myotoxicity and provides potential targets for therapeutic intervention.

  18. 78 FR 67379 - Chemical Transportation Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-12

    ... DEPARTMENT OF HOMELAND SECURITY Coast Guard [Docket No. USCG-2013-0927] Chemical Transportation... Committee Meeting. SUMMARY: The Chemical Transportation Advisory Committee (CTAC) and its Subcommittees and... it relates to the marine transportation of hazardous materials c. Update on Bulk Chemical Data Guide...

  19. Ratios of N15/C12 and He4/C12 inclusive electroproduction cross sections in the nucleon resonance region

    NASA Astrophysics Data System (ADS)

    Bosted, P. E.; Fersch, R.; Adams, G.; Amarian, M.; Anefalos, S.; Anghinolfi, M.; Asryan, G.; Avakian, H.; Bagdasaryan, H.; Baillie, N.; Ball, J. P.; Baltzell, N. A.; Barrow, S.; Batourine, V.; Battaglieri, M.; Beard, K.; Bedlinskiy, I.; Bektasoglu, M.; Bellis, M.; Benmouna, N.; Biselli, A. S.; Bonner, B. E.; Bouchigny, S.; Boiarinov, S.; Bradford, R.; Branford, D.; Brooks, W. K.; Bültmann, S.; Burkert, V. D.; Butuceanu, C.; Calarco, J. R.; Careccia, S. L.; Carman, D. S.; Carnahan, B.; Cazes, A.; Chen, S.; Cole, P. L.; Collins, P.; Coltharp, P.; Cords, D.; Corvisiero, P.; Crabb, D.; Crannell, H.; Crede, V.; Cummings, J. P.; de Masi, R.; de Vita, R.; de Sanctis, E.; Degtyarenko, P. V.; Denizli, H.; Dennis, L.; Deur, A.; Djalali, C.; Dodge, G. E.; Donnelly, J.; Doughty, D.; Dragovitsch, P.; Dugger, M.; Dharmawardane, K. V.; Dytman, S.; Dzyubak, O. P.; Egiyan, H.; Egiyan, K. S.; Elouadrhiri, L.; Eugenio, P.; Fatemi, R.; Fedotov, G.; Feuerbach, R. J.; Forest, T. A.; Fradi, A.; Funsten, H.; Garçon, M.; Gavalian, G.; Gilfoyle, G. P.; Giovanetti, K. L.; Girod, F. X.; Goetz, J. T.; Golovatch, E.; Gothe, R. W.; Griffioen, K. A.; Guidal, M.; Guillo, M.; Guler, N.; Guo, L.; Gyurjyan, V.; Hadjidakis, C.; Hafidi, K.; Hakobyan, R. S.; Hardie, J.; Heddle, D.; Hersman, F. W.; Hicks, K.; Hleiqawi, I.; Holtrop, M.; Huertas, M.; Hyde-Wright, C. E.; Ilieva, Y.; Ireland, D. G.; Ishkhanov, B. S.; Isupov, E. L.; Ito, M. M.; Jenkins, D.; Jo, H. S.; Joo, K.; Juengst, H. G.; Kalantarians, N.; Keith, C.; Kellie, J. D.; Khandaker, M.; Kim, K. Y.; Kim, K.; Kim, W.; Klein, A.; Klein, F. J.; Klusman, M.; Kossov, M.; Kramer, L. H.; Kubarovsky, V.; Kuhn, J.; Kuhn, S. E.; Kuleshov, S. V.; Lachniet, J.; Laget, J. M.; Langheinrich, J.; Lawrence, D.; Li, Ji; Lima, A. C. S.; Livingston, K.; Lu, H.; Lukashin, K.; MacCormick, M.; Markov, N.; McAleer, S.; McKinnon, B.; McNabb, J. W. C.; Mecking, B. A.; Mestayer, M. D.; Meyer, C. A.; Mibe, T.; Mikhailov, K.; Minehart, R.; Mirazita, M.; Miskimen, R.; Mokeev, V.; Morand, L.; Morrow, S. A.; Moteabbed, M.; Mueller, J.; Mutchler, G. S.; Nadel-Turonski, P.; Nasseripour, R.; Niccolai, S.; Niculescu, G.; Niculescu, I.; Niczyporuk, B. B.; Niroula, M. R.; Niyazov, R. A.; Nozar, M.; O'Rielly, G. V.; Osipenko, M.; Ostrovidov, A. I.; Park, K.; Pasyuk, E.; Paterson, C.; Philips, S. A.; Pierce, J.; Pivnyuk, N.; Pocanic, D.; Pogorelko, O.; Polli, E.; Pozdniakov, S.; Preedom, B. M.; Price, J. W.; Prok, Y.; Protopopescu, D.; Qin, L. M.; Raue, B. A.; Riccardi, G.; Ricco, G.; Ripani, M.; Rosner, G.; Rossi, P.; Rowntree, D.; Rubin, P. D.; Sabatié, F.; Salgado, C.; Santoro, J. P.; Sapunenko, V.; Schumacher, R. A.; Serov, V. S.; Sharabian, Y. G.; Shaw, J.; Shvedunov, N. V.; Skabelin, A. V.; Smith, E. S.; Smith, L. C.; Sober, D. I.; Stavinsky, A.; Stepanyan, S. S.; Stepanyan, S.; Stokes, B. E.; Stoler, P.; Strauch, S.; Suleiman, R.; Taiuti, M.; Taylor, S.; Tedeschi, D. J.; Thoma, U.; Tkabladze, A.; Tkachenko, S.; Todor, L.; Ungaro, M.; Vineyard, M. F.; Vlassov, A. V.; Weinstein, L. B.; Weygand, D. P.; Williams, M.; Wolin, E.; Wood, M. H.; Yegneswaran, A.; Yun, J.; Zana, L.; Zhang, J.; Zhao, B.; Zhao, Z.

    2008-07-01

    The (W,Q2) dependence of the ratio of inclusive electron scattering cross sections for N15/C12 was determined in the kinematic ranges 0.8C12 using 1.6 to 2.5 GeV electrons were measured with very high statistical precision and were used to correct for He in the N and C targets. The (W,Q2) dependence of the He4/C12 ratios is in good agreement with that of the phenomenological model and exhibit significant resonance structure centered at W=0.94,1.23, and 1.5 GeV.

  20. 77 FR 61432 - NASA Advisory Council; Aeronautics Committee; Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-09

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice 12-080] NASA Advisory Council; Aeronautics Committee; Meeting AGENCY: National Aeronautics and Space Administration. ACTION: Notice of Meeting. SUMMARY... Aeronautics and Space Administration announces a meeting of the Aeronautics Committee of the NASA Advisory...

  1. Development Committee. AGB Standing Committee Series.

    ERIC Educational Resources Information Center

    Kinnison, William

    1984-01-01

    The structure and functions of college development committees are discussed. The development committee of a board of trustees, also known as "the institutional advancement" committee, is responsible for ensuring the operation of the fund-raising program. Whether the development committee works through a foundation or directly for the…

  2. 7 CFR 29.2663 - Thin Leaf (C Group).

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 2 2014-01-01 2014-01-01 false Thin Leaf (C Group). 29.2663 Section 29.2663... REGULATIONS TOBACCO INSPECTION Standards Grades § 29.2663 Thin Leaf (C Group). This group consists of leaves that are thin in body. Grades Grade names and specifications C1L Choice Light-brown Thin Leaf. Thin...

  3. 7 CFR 29.2663 - Thin Leaf (C Group).

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 2 2011-01-01 2011-01-01 false Thin Leaf (C Group). 29.2663 Section 29.2663... REGULATIONS TOBACCO INSPECTION Standards Grades § 29.2663 Thin Leaf (C Group). This group consists of leaves that are thin in body. Grades Grade names and specifications C1L Choice Light-brown Thin Leaf. Thin...

  4. 7 CFR 29.3648 - Thin Leaf (C Group).

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Thin Leaf (C Group). 29.3648 Section 29.3648... REGULATIONS TOBACCO INSPECTION Standards Grades § 29.3648 Thin Leaf (C Group). This group consists of leaves... specifications, and tolerances C1L Choice Quality Light-brown Thin Leaf. Ripe, thin, open leaf structure, smooth...

  5. 7 CFR 29.2663 - Thin Leaf (C Group).

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Thin Leaf (C Group). 29.2663 Section 29.2663... REGULATIONS TOBACCO INSPECTION Standards Grades § 29.2663 Thin Leaf (C Group). This group consists of leaves that are thin in body. Grades Grade names and specifications C1L Choice Light-brown Thin Leaf. Thin...

  6. 7 CFR 29.2663 - Thin Leaf (C Group).

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 2 2013-01-01 2013-01-01 false Thin Leaf (C Group). 29.2663 Section 29.2663... REGULATIONS TOBACCO INSPECTION Standards Grades § 29.2663 Thin Leaf (C Group). This group consists of leaves that are thin in body. Grades Grade names and specifications C1L Choice Light-brown Thin Leaf. Thin...

  7. 7 CFR 29.2663 - Thin Leaf (C Group).

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 2 2012-01-01 2012-01-01 false Thin Leaf (C Group). 29.2663 Section 29.2663... REGULATIONS TOBACCO INSPECTION Standards Grades § 29.2663 Thin Leaf (C Group). This group consists of leaves that are thin in body. Grades Grade names and specifications C1L Choice Light-brown Thin Leaf. Thin...

  8. 7 CFR 29.3648 - Thin Leaf (C Group).

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 2 2012-01-01 2012-01-01 false Thin Leaf (C Group). 29.3648 Section 29.3648... REGULATIONS TOBACCO INSPECTION Standards Grades § 29.3648 Thin Leaf (C Group). This group consists of leaves... specifications, and tolerances C1L Choice Quality Light-brown Thin Leaf. Ripe, thin, open leaf structure, smooth...

  9. 7 CFR 29.3648 - Thin Leaf (C Group).

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 2 2013-01-01 2013-01-01 false Thin Leaf (C Group). 29.3648 Section 29.3648... REGULATIONS TOBACCO INSPECTION Standards Grades § 29.3648 Thin Leaf (C Group). This group consists of leaves... specifications, and tolerances C1L Choice Quality Light-brown Thin Leaf. Ripe, thin, open leaf structure, smooth...

  10. 7 CFR 29.3648 - Thin Leaf (C Group).

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 2 2011-01-01 2011-01-01 false Thin Leaf (C Group). 29.3648 Section 29.3648... REGULATIONS TOBACCO INSPECTION Standards Grades § 29.3648 Thin Leaf (C Group). This group consists of leaves... specifications, and tolerances C1L Choice Quality Light-brown Thin Leaf. Ripe, thin, open leaf structure, smooth...

  11. 7 CFR 29.3648 - Thin Leaf (C Group).

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 2 2014-01-01 2014-01-01 false Thin Leaf (C Group). 29.3648 Section 29.3648... REGULATIONS TOBACCO INSPECTION Standards Grades § 29.3648 Thin Leaf (C Group). This group consists of leaves... specifications, and tolerances C1L Choice Quality Light-brown Thin Leaf. Ripe, thin, open leaf structure, smooth...

  12. 75 FR 51239 - Census Scientific Advisory Committee; Notice of Public Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-19

    ... Advisory Committee (C-SAC). The Committee will address policy, research, and technical issues relating to a.... The Committee provides scientific and technical expertise, as appropriate, to address Census Bureau...

  13. 75 FR 19608 - Recreation Resource Advisory Committees

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-15

    ...;and investigations, committee meetings, agency decisions and rulings, #0;delegations of authority... tourism official to represent the State; b. A person who represents affected Indian tribes; and c. A... reimbursed for travel and per diem expenses for regularly scheduled committee meetings. All Recreation RAC...

  14. 77 FR 62621 - Advisory Committee Charter Renewals

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-15

    ... DEPARTMENT OF VETERANS AFFAIRS Advisory Committee Charter Renewals AGENCY: Department of Veterans... Federal advisory committees are vital to the mission of the Department of Veterans Affairs (VA) and....S.C. 541. March 20, 2012. War. Provides advice on the administration of benefits for veterans who...

  15. 40 CFR 180.1250 - C8, C10, and C12 fatty acid monoesters of glycerol and propylene glycol; exemption from the...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false C8, C10, and C12 fatty acid monoesters..., C10, and C12 fatty acid monoesters of glycerol and propylene glycol; exemption from the requirement of a tolerance. The C8, C10, and C12 straight-chain fatty acid monoesters of glycerol (glycerol...

  16. 40 CFR 180.1250 - C8, C10, and C12 fatty acid monoesters of glycerol and propylene glycol; exemption from the...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 24 2011-07-01 2011-07-01 false C8, C10, and C12 fatty acid monoesters..., C10, and C12 fatty acid monoesters of glycerol and propylene glycol; exemption from the requirement of a tolerance. The C8, C10, and C12 straight-chain fatty acid monoesters of glycerol (glycerol...

  17. Cluster correlation and fragment emission in 12C+12C at 95 MeV/nucleon

    NASA Astrophysics Data System (ADS)

    Tian, G.; Chen, Z.; Han, R.; Shi, F.; Luo, F.; Sun, Q.; Song, L.; Zhang, X.; Xiao, G. Q.; Wada, R.; Ono, A.

    2018-03-01

    The impact of cluster correlations has been studied in the intermediate mass fragment (IMF) emission in 12C+12C at 95 MeV/nucleon, using antisymmetrized molecular dynamics (AMD) model simulations. In AMD, the cluster correlation is introduced as a process to form light clusters with A ≤4 in the final states of a collision induced by the nucleon-nucleon residual interaction. Correlations between light clusters are also considered to form light nuclei with A ≤9 . This version of AMD, combined with GEMINI to calculate the decay of primary fragments, reproduces the experimental energy spectra of IMFs well overall with reasonable reproduction of light charged particles when we carefully analyze the excitation energies of primary fragments produced by AMD and their secondary decays. The results indicate that the cluster correlation plays a crucial role for producing fragments at relatively low excitation energies in the intermediate-energy heavy-ion collisions.

  18. Low-molecular-weight fucoidan regulates myogenic differentiation through the mitogen-activated protein kinase pathway in C2C12 cells.

    PubMed

    Kim, Kui-Jin; Lee, Ok-Hwan; Lee, Boo-Yong

    2011-12-01

    Low-molecular-weight fucoidan (LMWF) has been broadly studied in recent years due to its numerous biological properties. Nevertheless, there have been no reports about the effects of LMWF on myogenic differentiation (MyoD). The objective of the present study was to demonstrate the impact of LMWF on myogenesis in C2C12 cells. The ultimate aim was to establish whether LMWF regulates myogenesis similar to heparin as a partial regulator of myogenesis. LMWF was prepared at a minimal size by ultra-filtration compared with crude fucoidan. We treated C2C12 cells with LMWF and/or heparin during MyoD. The data from the present study are the first to suggest that LMWF suppresses the expression of the myogenic regulatory factors and the myocyte enhancer factors as well as the morphological changes that occur during differentiation. Additionally, the expression of the mitogen-activated protein kinase (MAPK) family was significantly inhibited by LMWF when compared with controls. The LMWF-treated group showed significantly decreased expression of reactive oxygen species (ROS) enzymes compared with control cells. Heparin was used as a positive control because it has been reported to activate MyoD. Taken together, these results suggest that LMWF might regulate MyoD through the MAPK pathway and by regulating ROS activity in C2C12 cells.

  19. International consensus for neuroblastoma molecular diagnostics: report from the International Neuroblastoma Risk Group (INRG) Biology Committee

    PubMed Central

    Ambros, P F; Ambros, I M; Brodeur, G M; Haber, M; Khan, J; Nakagawara, A; Schleiermacher, G; Speleman, F; Spitz, R; London, W B; Cohn, S L; Pearson, A D J; Maris, J M

    2009-01-01

    Neuroblastoma serves as a paradigm for utilising tumour genomic data for determining patient prognosis and treatment allocation. However, before the establishment of the International Neuroblastoma Risk Group (INRG) Task Force in 2004, international consensus on markers, methodology, and data interpretation did not exist, compromising the reliability of decisive genetic markers and inhibiting translational research efforts. The objectives of the INRG Biology Committee were to identify highly prognostic genetic aberrations to be included in the new INRG risk classification schema and to develop precise definitions, decisive biomarkers, and technique standardisation. The review of the INRG database (n=8800 patients) by the INRG Task Force finally enabled the identification of the most significant neuroblastoma biomarkers. In addition, the Biology Committee compared the standard operating procedures of different cooperative groups to arrive at international consensus for methodology, nomenclature, and future directions. Consensus was reached to include MYCN status, 11q23 allelic status, and ploidy in the INRG classification system on the basis of an evidence-based review of the INRG database. Standardised operating procedures for analysing these genetic factors were adopted, and criteria for proper nomenclature were developed. Neuroblastoma treatment planning is highly dependant on tumour cell genomic features, and it is likely that a comprehensive panel of DNA-based biomarkers will be used in future risk assignment algorithms applying genome-wide techniques. Consensus on methodology and interpretation is essential for uniform INRG classification and will greatly facilitate international and cooperative clinical and translational research studies. PMID:19401703

  20. 12. 'Erection Plan, 1 180'01/4' c. to c. End ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. 'Erection Plan, 1 - 180'-0-1/4' c. to c. End Pins Sing. Tr. Thro' Span, 16th Crossing over Sacramento River, Pacific System, Southern Pacific Co., Phoenix Bridge Co., C.O. #842, Drawing #13, Scale 1/8' & 1' = 1'-0', Eng'r C. Scheidl, Draftsman D. Sharp, Scale 1' = 1'-0', May 1st 1901.' - Southern Pacific Railroad Shasta Route, Bridge No. 324.99, Milepost 324.99, Shasta Springs, Siskiyou County, CA

  1. 17 CFR 240.15c1-2 - Fraud and misrepresentation.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Fraud and misrepresentation. 240.15c1-2 Section 240.15c1-2 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION... Securities Exchange Act of 1934 Rules Relating to Over-The-Counter Markets § 240.15c1-2 Fraud and...

  2. 26 CFR 1.412(c)(1)-2 - Shortfall method.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 5 2010-04-01 2010-04-01 false Shortfall method. 1.412(c)(1)-2 Section 1.412(c... (CONTINUED) INCOME TAXES Pension, Profit-Sharing, Stock Bonus Plans, Etc. § 1.412(c)(1)-2 Shortfall method. (a) In general—(1) Shortfall method. The shortfall method is a funding method that adapts a plan's...

  3. 77 FR 51817 - National Maritime Security Advisory Committee; Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-27

    ... the information sharing efforts of the Coast Guard and DHS. (2) Cyber-Security. The Committee will... DEPARTMENT OF HOMELAND SECURITY Coast Guard [USCG-2012-0797] National Maritime Security Advisory...: The National Maritime Security Advisory Committee (NMSAC) will meet on September 11-12, 2012 in the...

  4. 77 FR 19007 - Renewal of Department of Defense Federal Advisory Committees

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-29

    ... engage in Committee deliberations. Committee members, who are not full-time or permanent part-time... of 5 U.S.C. 3109 and shall serve as special government employee members. With the exception of travel and per diem for official Committee related travel, Committee members shall serve without compensation...

  5. Towards Understanding the DO-178C / ED-12C Assurance Case

    NASA Technical Reports Server (NTRS)

    Holloway, C M.

    2012-01-01

    This paper describes initial work towards building an explicit assurance case for DO-178C / ED-12C. Two specific questions are explored: (1) What are some of the assumptions upon which the guidance in the document relies, and (2) What claims are made concerning test coverage analysis?

  6. 77 FR 30304 - Merchant Marine Personnel Advisory Committee: Intercessional Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-22

    ... Committee Working Group Meeting. SUMMARY: A working group of the Merchant Marine Personnel Advisory Committee (MERPAC) will meet to discuss Task Statement 76, ``Review of Performance Measures (Assessment Criteria);'' and Task Statement 77, ``Development of Performance Measures (Assessment Criteria).'' This...

  7. 76 FR 17180 - Advisory Committee on International Economic Policy; Notice of Committee Renewal

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-28

    ... provides information and advice on the effective integration of economic interests into overall foreign... groups, and trade and professional associations. The Committee meets at least annually to advise the...

  8. 12 CFR 272.1 - Authority.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Authority. 272.1 Section 272.1 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) FEDERAL OPEN MARKET COMMITTEE RULES OF PROCEDURE § 272.1 Authority. This part is issued by the Federal Open Market Committee (the Committee) pursuant to the...

  9. 78 FR 23333 - Special Medical Advisory Group, Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-18

    ... DEPARTMENT OF VETERANS AFFAIRS Special Medical Advisory Group, Notice of Meeting The Department of Veterans Affairs (VA) gives notice under the Federal Advisory Committee Act, 5 U.S.C. App. 2, that the Special Medical Advisory Group will meet on May 1, 2013, in Room 830 at VA Central Office, 810 Vermont...

  10. 50 CFR 600.133 - Scientific and Statistical Committee (SSC).

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 12 2014-10-01 2014-10-01 false Scientific and Statistical Committee (SSC). 600.133 Section 600.133 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC... Fishery Management Councils § 600.133 Scientific and Statistical Committee (SSC). (a) Each Council shall...

  11. Identification of high-risk Listeria monocytogenes serotypes in lineage I (serotype 1/2a, 1/2c, 3a and 3c) using multiplex PCR

    USDA-ARS?s Scientific Manuscript database

    Aims: Using molecular subtyping techniques, Listeria monocytogenes is divided into three major phylogenetic lineages, and a multiplex PCR method can differentiate five L. monocytogenes subgroups: 1/2a-3a, 1/2c-3c, 1/2b-3b-7, 4b-4d-4e, and 4a-4c. In the current study, we conducted genome comparison...

  12. Comparison of characteristics of {Delta}{sup 0}(1232) produced in p{sup 12}C and d{sup 12}C collisions at 4.2 A GeV/c

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Olimov, Kh. K., E-mail: olimov@comsats.edu.pk; Haseeb, Mahnaz Q., E-mail: mahnazhaseeb@comsats.edu.pk; Khan, Imran

    2012-04-15

    Reconstructed momentum, transverse momentum, kinetic energy, rapidity, and emission angle distributions along with their mean values were compared for {Delta}{sup 0}(1232) resonances produced in p{sup 12}C and d{sup 12}C collisions at 4.2 A GeV/c. Mean momentum, transverse momentum, and rapidity of protons and negative pions coming from {Delta}{sup 0}(1232) decay were extracted and compared with the corresponding mean values for protons and {pi}{sup -} mesons in experiment and the relevant model calculations.

  13. 75 FR 55306 - Smart Grid Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-10

    ... orientation for Committee members and provide an update on NIST's Smart Grid program. The agenda may change to accommodate Committee business. The final agenda will be posted on the Smart Grid Web site at http://www.nist... Room C, in the Administration Building at NIST in Gaithersburg, Maryland. Please note admittance...

  14. 77 FR 28640 - Federal Prevailing Rate Advisory Committee; Cancellation of Upcoming Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-15

    ... OFFICE OF PERSONNEL MANAGEMENT Federal Prevailing Rate Advisory Committee; Cancellation of... Prevailing Rate Advisory Committee is issuing this notice to cancel the May 24, 2012, public meeting..., Federal Prevailing Rate Advisory Committee. [FR Doc. 2012-11728 Filed 5-14-12; 8:45 am] BILLING CODE 6325...

  15. Human Space Flight Plans Committee

    NASA Image and Video Library

    2009-08-12

    Former astronaut Dr. Sally Ride, left, confers with Norman Augustine, chair, prior to the start of the final meeting of the Human Space Flight Review Committee, Wednesday, Aug. 12, 2009, in Washington. Photo Credit: (NASA/Paul E. Alers)

  16. Human Space Flight Plans Committee

    NASA Image and Video Library

    2009-12-07

    Former astronaut Dr. Sally Ride, left, confers with Norman Augustine, chair, prior to the start of the final meeting of the Human Space Flight Review Committee, Wednesday, Aug. 12, 2009, in Washington. Photo Credit: (NASA/Paul E. Alers)

  17. Apoptosis in differentiating C2C12 muscle cells selectively targets Bcl-2-deficient myotubes

    PubMed Central

    Schoneich, Christian; Dremina, Elena; Galeva, Nadezhda; Sharov, Victor

    2014-01-01

    Muscle cell apoptosis accompanies normal muscle development and regeneration, as well as degenerative diseases and aging. C2C12 murine myoblast cells represent a common model to study muscle differentiation. Though it was already shown that myogenic differentiation of C2C12 cells is accompanied by enhanced apoptosis in a fraction of cells, either the cell population sensitive to apoptosis or regulatory mechanisms for the apoptotic response are unclear so far. In the current study we characterize apoptotic phenotypes of different types of C2C12 cells at all stages of differentiation, and report here that myotubes of differentiated C2C12 cells with low levels of anti-apoptotic Bcl-2 expression are particularly vulnerable to apoptosis even though they are displaying low levels of pro-apoptotic proteins Bax, Bak and Bad. In contrast, reserve cells exhibit higher levels of Bcl-2 and high resistance to apoptosis. The transfection of proliferating myoblasts with Bcl-2 prior to differentiation did not protect against spontaneous apoptosis accompanying differentiation of C2C12 cell but led to Bcl-2 overexpression in myotubes and to significant protection from apoptotic cell loss caused by exposure to hydrogen peroxide. Overall, our data advocate for a Bcl-2-dependent mechanism of apoptosis in differentiated muscle cells. However, downstream processes for spontaneous and hydrogen peroxide induced apoptosis are not completely similar. Apoptosis in differentiating myoblasts and myotubes is regulated not through interaction of Bcl-2 with pro-apoptotic Bcl-2 family proteins such as Bax, Bak, and Bad. PMID:24129924

  18. 77 FR 58383 - Secretary's Advisory Committee on Human Research Protections

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-20

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Secretary's Advisory Committee on Human Research... Committee Act, U.S.C. Appendix 2, notice is hereby given that the Secretary's Advisory Committee on Human Research Protections (SACHRP) will hold its twenty-ninth meeting. The meeting will be open to the public...

  19. 77 FR 37408 - Secretary's Advisory Committee on Human Research Protections

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-21

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Secretary's Advisory Committee on Human Research... Committee Act, U.S.C. Appendix 2, notice is hereby given that the Secretary's Advisory Committee on Human Research Protections (SACHRP) will hold its twenty-eighth meeting. The meeting will be open to the public...

  20. 75 FR 14205 - Engineering Advisory Committee; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-24

    ... NATIONAL SCIENCE FOUNDATION Engineering Advisory Committee; Notice of Meeting In accordance with... following meeting: Name: Advisory Committee for Engineering, 1170. Date/Time: April 14, 2010: 12 p.m. to 6 p... engineering programs and activities. Agenda: The principal focus of the meeting on both days will be to...

  1. EFFECTS OF NUCLEAR INDUCED BREAKUP ON THE FUSION OF 6Li+12C AND 6He+12C SYSTEMS AROUND BARRIER ENERGIES

    NASA Astrophysics Data System (ADS)

    Duhan, Sukhvinder S.; Singh, Manjeet; Kharab, Rajesh

    2012-06-01

    We have studied the effects of nuclear induced breakup channel coupling on the fusion cross-section for 6Li+12C and 6He+12C systems in the near barrier energy regime using the dynamic polarization potential (DPP) approach. It has been found that there is enhancement in the fusion cross-section with respect to standard one-dimensional barrier penetration model in the below barrier energy regime while at energies above the barrier there is suppression of fusion cross-section with respect to simple barrier penetration model is observed. The agreement between data and predictions for 6Li+12C system improves significantly as a result of the inclusion of nuclear induced DPP.

  2. 22 CFR 214.12 - Considerations in membership selection.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Considerations in membership selection. 214.12 Section 214.12 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ADVISORY COMMITTEE MANAGEMENT Establishment of Advisory Committees § 214.12 Considerations in membership selection. Membership is to be fairly...

  3. 77 FR 1944 - Merchant Marine Personnel Advisory Committee: Intercessional Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-12

    ... Performance Measures (Assessment Criteria).'' This meeting will be open to the public. DATES: A MERPAC working..., working group meeting is as follows: (1) Review existing performance measures and develop new performance... Committee Working Group Meeting. SUMMARY: The Merchant Marine Personnel Advisory Committee (MERPAC) will...

  4. 77 FR 11142 - Merchant Marine Personnel Advisory Committee: Intercessional Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-24

    ... Committee working group meeting. SUMMARY: The Merchant Marine Personnel Advisory Committee (MERPAC) will conduct an intercessional meeting so that a working group may discuss Task Statement 76, entitled ``Review of Performance Measures (Assessment Criteria).'' This meeting will be open to the public. DATES: A...

  5. Neutron Scattering Differential Cross Sections for 12C

    NASA Astrophysics Data System (ADS)

    Byrd, Stephen T.; Hicks, S. F.; Nickel, M. T.; Block, S. G.; Peters, E. E.; Ramirez, A. P. D.; Mukhopadhyay, S.; McEllistrem, M. T.; Yates, S. W.; Vanhoy, J. R.

    2016-09-01

    Because of the prevalence of its use in the nuclear energy industry and for our overall understanding of the interactions of neutrons with matter, accurately determining the effects of fast neutrons scattering from 12C is important. Previously measured 12C inelastic neutron scattering differential cross sections found in the National Nuclear Data Center (NNDC) show significant discrepancies (>30%). Seeking to resolve these discrepancies, neutron inelastic and elastic scattering differential cross sections for 12C were measured at the University of Kentucky Acceleratory Laboratory for incident neutron energies of 5.58, 5.83, and 6.04 MeV. Quasi mono-energetic neutrons were scattered off an enriched 12C target (>99.99%) and detected by a C6D6 liquid scintillation detector. Time-of-flight (TOF) techniques were used to determine scattered neutron energies and allowed for elastic/inelastic scattering distinction. Relative detector efficiencies were determined through direct measurements of neutrons produced by the 2H(d,n) and 3H(p,n) source reactions, and absolute normalization factors were found by comparing 1H scattering measurements to accepted NNDC values. This experimental procedure has been successfully used for prior neutron scattering measurements and seems well-suited to our current objective. Significant challenges were encountered, however, with measuring the neutron detector efficiency over the broad incident neutron energy range required for these measurements. Funding for this research was provided by the National Nuclear Security Administration (NNSA).

  6. Investigating {sup 13}C+{sup 12}C reaction by the activation method. Sensitivity tests

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Chesneanu, Daniela, E-mail: chesneanu@nipne.ro; Trache, L.; Margineanu, R.

    2015-02-24

    We have performed experiments to check the limits of sensitivity of the activation method using the new 3 MV Tandetron accelerator and the low and ultra-low background laboratories of the “Horia Hulubei” National Institute of Physics and Nuclear Engineering (IFIN-HH). We have used the {sup 12}C+{sup 13}C reaction at beam energies E{sub lab}= 6, 7 and 8 MeV. The knowledge of this fusion cross section at deep sub-barrier energies is of interest for astrophysical applications, as it provides an upper limit for the fusion cross section of {sup 12}C+{sup 12}C over a wide energy range. A {sup 13}C beam withmore » intensities 0.5–2 particleμA was provided by the accelerator and used to bombard graphite targets, resulting in activation with {sup 24}Na from the {sup 12}C({sup 13}C,p) reaction. The 1369 and 2754 keV gamma-rays from {sup 24}Na de-activation were clearly observed in the spectra obtained in two different laboratories used for measurements at low and ultralow background: one at the surface and one located underground in the Unirea salt mine from Slanic Prahova, Romania. In the underground laboratory, for E{sub lab} = 6 MeV we have measured an activity of 0.085 ± 0.011 Bq, corresponding to cross sections of 1–3 nb. This demonstrates that it is possible to measure {sup 12}C targets irradiated at lower energies for at least 10 times lower cross sections than before β–γ coincidences will lead us another factor of 10 lower, proving that this installations can be successfully used for nuclear astrophysics measurements.« less

  7. Research ethical committees in Scotland.

    PubMed Central

    Thompson, I E; French, K; Melia, K M; Boyd, K M; Templeton, A A; Potter, B

    1981-01-01

    A questionnaire was sent to 41 ethical committees in Scotland requesting information about their constitution and supervision of clinical research. Thirty-four (83%) replies were received. Committees varied in size from one to 73 members, most of whom were medical. Ten had no nurse members and only three had lay members without direct NHS connections. Sixteen saw their role as advisory rather than supervisory. Thirteen had not met in the past year whereas two had held 10 or more meetings. Limited use (12) was made of standard protocols, and only six had formal procedures for monitoring research in progress. Only seven of 370 proposals were rejected outright. Risk/benefit dilemmas and difficulties relating to informed consent were the commonest problems encountered. The committees provide only limited safeguards for patients and research workers, and more effective, standardised procedures are indicated. PMID:6781629

  8. 77 FR 67028 - NASA Advisory Council; Commercial Space Committee; Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-08

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice 12-093] NASA Advisory Council; Commercial..., the National Aeronautics and Space Administration (NASA) announces a meeting of the Commercial Space Committee of the NASA Advisory Council (NAC). This Committee reports to the NAC. The [[Page 67029

  9. 76 FR 23568 - Civil Nuclear Trade Advisory Committee Public Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-27

    ... DEPARTMENT OF COMMERCE International Trade Administration Civil Nuclear Trade Advisory Committee... Civil Nuclear Trade Advisory Committee (CINTAC). DATES: The meeting is scheduled for Thursday, May 12... programs to expand United States exports of civil nuclear goods and services in accordance with applicable...

  10. 78 FR 34101 - National Committee on Vital and Health Statistics: Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-06

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Committee on Vital and Health Statistics: Meeting... the following advisory committee meeting. Name: National Committee on Vital and Health Statistics... Health Statistics, 3311 Toledo Road, Auditorium B & C, Hyattsville, Maryland 20782, (301) 458-4524...

  11. 45 CFR 640.2 - Committee on Environmental Matters.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 640.2 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION COMPLIANCE WITH THE NATIONAL ENVIRONMENTAL POLICY ACT § 640.2 Committee on Environmental Matters. (a) There... replies to such correspondence. (c) The Committee shall meet regularly to discuss NSF policies and...

  12. 45 CFR 640.2 - Committee on Environmental Matters.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 640.2 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION COMPLIANCE WITH THE NATIONAL ENVIRONMENTAL POLICY ACT § 640.2 Committee on Environmental Matters. (a) There... replies to such correspondence. (c) The Committee shall meet regularly to discuss NSF policies and...

  13. 45 CFR 640.2 - Committee on Environmental Matters.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 640.2 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION COMPLIANCE WITH THE NATIONAL ENVIRONMENTAL POLICY ACT § 640.2 Committee on Environmental Matters. (a) There... replies to such correspondence. (c) The Committee shall meet regularly to discuss NSF policies and...

  14. 45 CFR 640.2 - Committee on Environmental Matters.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 640.2 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION COMPLIANCE WITH THE NATIONAL ENVIRONMENTAL POLICY ACT § 640.2 Committee on Environmental Matters. (a) There... replies to such correspondence. (c) The Committee shall meet regularly to discuss NSF policies and...

  15. 45 CFR 640.2 - Committee on Environmental Matters.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 640.2 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION COMPLIANCE WITH THE NATIONAL ENVIRONMENTAL POLICY ACT § 640.2 Committee on Environmental Matters. (a) There... replies to such correspondence. (c) The Committee shall meet regularly to discuss NSF policies and...

  16. 7 CFR 29.2438 - Thin Leaf (C Group).

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 2 2013-01-01 2013-01-01 false Thin Leaf (C Group). 29.2438 Section 29.2438... REGULATIONS TOBACCO INSPECTION Standards Grades § 29.2438 Thin Leaf (C Group). This group consists of leaves usually grown at the center portion of the stalk. These leaves normally have a rounded tip, are thinner in...

  17. 7 CFR 29.2438 - Thin Leaf (C Group).

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 2 2014-01-01 2014-01-01 false Thin Leaf (C Group). 29.2438 Section 29.2438... REGULATIONS TOBACCO INSPECTION Standards Grades § 29.2438 Thin Leaf (C Group). This group consists of leaves usually grown at the center portion of the stalk. These leaves normally have a rounded tip, are thinner in...

  18. 7 CFR 29.2438 - Thin Leaf (C Group).

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 2 2011-01-01 2011-01-01 false Thin Leaf (C Group). 29.2438 Section 29.2438... REGULATIONS TOBACCO INSPECTION Standards Grades § 29.2438 Thin Leaf (C Group). This group consists of leaves usually grown at the center portion of the stalk. These leaves normally have a rounded tip, are thinner in...

  19. 7 CFR 29.2438 - Thin Leaf (C Group).

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Thin Leaf (C Group). 29.2438 Section 29.2438... REGULATIONS TOBACCO INSPECTION Standards Grades § 29.2438 Thin Leaf (C Group). This group consists of leaves usually grown at the center portion of the stalk. These leaves normally have a rounded tip, are thinner in...

  20. 7 CFR 29.2438 - Thin Leaf (C Group).

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 2 2012-01-01 2012-01-01 false Thin Leaf (C Group). 29.2438 Section 29.2438... REGULATIONS TOBACCO INSPECTION Standards Grades § 29.2438 Thin Leaf (C Group). This group consists of leaves usually grown at the center portion of the stalk. These leaves normally have a rounded tip, are thinner in...

  1. 76 FR 1460 - Maritime Advisory Committee for Occupational Safety and Health (MACOSH); Committee Reestablishment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-10

    ... duties imposed by the Occupational Safety and Health (OSH) Act of 1970 (29 U.S.C. 655, 656). Authority to...(b) of the Occupational Safety and Health Act of 1970 (29 U.S.C. 655(b)(1), 656(b)), the Federal... DEPARTMENT OF LABOR Occupational Safety and Health Administration Maritime Advisory Committee for...

  2. 12C/13C isotopic ratios in red-giant stars of the open cluster NGC 6791

    NASA Astrophysics Data System (ADS)

    Szigeti, László; Mészáros, Szabolcs; Smith, Verne V.; Cunha, Katia; Lagarde, Nadège; Charbonnel, Corinne; García-Hernández, D. A.; Shetrone, Matthew; Pinsonneault, Marc; Allende Prieto, Carlos; Fernández-Trincado, J. G.; Kovács, József; Villanova, Sandro

    2018-03-01

    Carbon isotope ratios, along with carbon and nitrogen abundances, are derived in a sample of 11 red-giant members of one of the most metal-rich clusters in the Milky Way, NGC 6791. The selected red-giants have a mean metallicity and standard deviation of [Fe/H] = +0.39 ± 0.06 (Cunha et al. 2015). We used high-resolution H-band spectra obtained by the SDSS-IV Apache Point Observatory Galactic Evolution Experiment. The advantage of using high-resolution spectra in the H band is that lines of CO are well represented and their line profiles are sensitive to the variation of 12C/13C. Values of the 12C/13C ratio were obtained from a spectrum synthesis analysis. The derived 12C/13C ratios varied between 6.3 and 10.6 in NGC 6791, in agreement with the final isotopic ratios from thermohaline-induced mixing models. The ratios derived here are combined with those obtained for more metal poor red-giants from the literature to examine the correlation between 12C/13C, mass, metallicity, and evolutionary status.

  3. [Ethics committees in the experience of the IMSS: a Latin American instance].

    PubMed

    Valdez-Martínez, Edith; Mata-Valderrama, Guadalupe; Bedolla, Miguel; Fajardo-Dolci, Germán Enrique

    2015-01-01

    The aim of this article is to identify the current state of hospital bioethics committees and local research ethics committees of the Mexican Institute of Social Security (IMSS). A descriptive cross-sectional study was performed that included all hospitals of the IMSS (N = 262). Two self-administered questionnaires were e-mailed between october and november 2014 to the hospital directors: one for hospital bioethics committees and another for local research ethics committees. Both questionnaires had five sections: committee location, date of committee set up, activity situation, composition, functions, and experience. The response rate was 85 %. It was reported 150 active hospital bioethics committees and 67 active local research ethics committees. In both groups physicians and executive directors dominated committees' membership, and lay people were reported only in seven hospital bioethics committees. The primary function of hospital bioethics committees was case consultation, and their primary goal "to improve the quality of medical care". Local Research Ethics Committees reported as primary function "to evaluate health research protocols and rule of them", and as their primary goal "to protect the rights and wellbeing of the research subjects". Both groups of committees ought to be assessed regularly through audit cycles in order to identify the educative actions that enhance their efficiency.

  4. 75 FR 18487 - Committee Termination and Committee Establishment-Department of Defense Federal Advisory Committees

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-12

    ... DEPARTMENT OF DEFENSE Office of the Secretary Committee Termination and Committee Establishment--Department of Defense Federal Advisory Committees AGENCY: Department of Defense (DoD). ACTION: Committee... Department of Defense announces: the establishment of the Board of Advisors to the Presidents of the Naval...

  5. 40 CFR 721.10007 - Alcohols, C12-14-secondary, ethoxylated propoxylated.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Alcohols, C12-14-secondary... New Uses for Specific Chemical Substances § 721.10007 Alcohols, C12-14-secondary, ethoxylated... identified as alcohols, C12-14- secondary, ethoxylated propoxylated (PMN P-00-11; CAS No. 103331-86-8) is...

  6. Rotational excitation of the Hoyle state in 12C

    NASA Astrophysics Data System (ADS)

    Garg, R.; Barton, C.; Diget, C. Aa; Courtin, S.; Fruet, G.; Fynbo, H. O. U.; Howard, A.; Illana, A.; Jenkins, D. G.; Marroquin, I.; Kirsebom, O. S.; Lund, M. V.; Moore, I.; Perea, A.; Refsgaard, J.; Riley, J. E.; Rinta-Antila, S.; Sinclair, L.; Tengblad, O.; IGISOL Collaboration

    2018-01-01

    12C is synthesised in stars by fusion of three α particles. This process occurs through a resonance in the 12C nucleus, famously known as the Hoyle state. In this state, the 12C nucleus exists as a cluster of α particles. The state is the band-head for a rotational band with the 2+ rotational excitation predicted in the energy region 9 - 11 MeV. This rotational excitation can affect the triple-α process reaction rate by more than an order of magnitude at high temperatures (109 K). Depending on the energy of the resonance, the knowledge of the state can also help determine the structure of the Hoyle state. In the work presented here, the state of interest is populated by beta decay of radioactive 12N ion beam delivered by the IGISOL facility at JYFL, Jyväskylä.

  7. 77 FR 38678 - NASA Advisory Council; Commercial Space Committee; Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-28

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (12-052)] NASA Advisory Council; Commercial..., the National Aeronautics and Space Administration (NASA) announces a meeting of the Commercial Space Committee of the NASA Advisory Council (NAC). This Committee reports to the NAC. The meeting will be held...

  8. 76 FR 76162 - Federal Open Market Committee; Domestic Policy Directive of November 1-2, 2011

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-06

    ... approximately 6 years to 30 years with a total face value of $400 billion, and to sell Treasury securities with remaining maturities of 3 years or less with a total face value of $400 billion. The Committee also directs... face value of domestic securities at approximately $2.6 trillion. The Committee directs the Desk to...

  9. 76 FR 70412 - Smart Grid Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-14

    ... recommendations that the Committee will consider at the meeting will be posted on the SGAC Web site at http://www... posted on the Smart Grid Web site at http://www.nist.gov/smartgrid . DATES: The SGAC will hold a meeting... (5 U.S.C. App.). Background information on the Committee is available at http://www.nist.gov...

  10. Complementation studies in Niemann-Pick disease type C indicate the existence of a second group.

    PubMed Central

    Steinberg, S J; Ward, C P; Fensom, A H

    1994-01-01

    Niemann-Pick disease type C is a clinically heterogeneous storage disorder with an unknown primary metabolic defect. We have undertaken somatic cell hybridisation experiments using skin fibroblast strains from 12 patients representing a wide clinical spectrum. Preliminary experiments using filipin staining of free cholesterol as a marker for complementation indicated the existence of one major group (group alpha) and one minor group (group beta) represented by one mutant strain. Subsequent experiments in which sphingomyelinase activity was measured as a marker for complementation using five mutant strains showing activity consistently < 40% control levels confirmed the existence of the second group. Images PMID:8071958

  11. 77 FR 23250 - HIT Standards Committee; Schedule for the Assessment of HIT Policy Committee Recommendations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-18

    ... quality, clinical operations, implementation, and privacy and security. Other groups are convened to address specific issues as needed, such as the Nationwide Health Information Network Power Team, the... appropriate workgroup or other special group to develop a report for the HIT Standards Committee, to the...

  12. Investigation of the Herzberg (C1Σ+→A1Π) band system in 12C17O

    NASA Astrophysics Data System (ADS)

    Hakalla, Rafał

    2015-10-01

    The C→A (0,1), (0,2) and (0,3) rovibronic bands of the less-abundant 12C17O isotopologue are studied in high resolution using a high-accuracy dispersive optical spectroscopy in the region of 22,800-26,100 cm-1. Calibration with respect to simultaneously recorded thorium atomic lines, obtained from several overlapped orders of the spectrum in the visible range, as well as a stainless steel hollow-cathode molecular lamp with two anodes, yields an absolute accuracy of wavenumbers measurements of about 0.0025 cm-1 for the CO spectra. All 261 spectra lines of the Herzberg band system in 12C17O, up to Jmax=34, were precisely measured and rotationally analyzed. As a result, the merged rotational constants and rotational equilibrium constants for the C1Σ+ Rydberg state, as well as the band origins, the isotope shifts, the RKR turning points, Franck-Condon factors, relative intensities, and r-centroids of the C→A system in the 12C17O isotopologue were obtained. An experimental RKR potential energy curve and vibrational levels of the C1Σ+ state in 12C17O together with highly excited k3Π, c3Π, E1Π, B1Σ+ and D‧1Σ+ states lying in the region between the first dissociation limit and the ionization potential of CO were plotted. A detailed investigation of possible perturbations that should occur in the C1Σ+(υ=0) Rydberg state of less-abundant 12C17O isotopologue in the close vicinity of the k3Π(υ=1, 2) and c3Π(υ=0) states in the region 92,000 cm-1 was performed. In the A1Π, υ=3 state of 12C17O, extensive, multi-state rotational perturbations were found and analyzed. Also, a global isotopic analysis of the C1Σ+ Rydberg state was carried out in the 12C16O, 12C17O, 13C16O, 12C18O, 13C17O, and 13C18O as well as in 14C16O and 14C18O isotopologues. This analysis enabled us to determine, amongst others, the vibrational equilibrium constants in 12C17O for the C1Σ+ state, to improve these constants in the 12C16O, 13C16O, 12C18O, 13C17O, and 13C18O isotopologues and

  13. Grafting C8-C16 alkyl groups altered the self-assembly and curcumin -loading properties of sodium caseinate in water.

    PubMed

    Zhang, Yaqiong; Yang, Puyu; Yao, Fangyi; Liu, Jie; Yu, Liangli Lucy

    2018-02-01

    The data presented here are related to the research article entitled "Synthesis and characterization of alkylated caseinate, and its structure-curcumin loading property relationship in water" (Zhang et al., 2018) [1]. This data article reports the detailed spectra information for 1 H NMR, 13 C NMR and UPLC-Q-TOF MS of the N-succinimidyl fatty acid esters with various alkyl chain lengths (Cn-NHSs, n = 8, 12, 14 and 16). 1 H NMR, 13 C NMR and UPLC-Q-TOF MS spectra for C16-NHS are shown as an example. Then the stacked 1 H NMR spectra of the obtained alkylated caseinates (Cn-caseinates, n = 8, 12, 14 and 16) are provided. The surface hydrophobicity index (S 0 ) of Cn-caseinates with different substitution degrees (SD) of alkyl groups is shown. Additionally, Visual appearances for the formed aqueous dispersions of curcumin-loaded native caseinate (NaCas) and Cn-caseinates self-assemblies are shown. X-ray diffraction patterns of curcumin, C16-caseinate, its physical mixture and curcumin-loaded C16-caseinate self-assemblies are examined. The re-dispersibility and short-term storage stability of the curcumin-loaded NaCas and C16-caseinate self-assemblies are also studied.

  14. 40 CFR 721.644 - Amines, C12-14-tert-alkyl, sulfonates.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Amines, C12-14-tert-alkyl, sulfonates... Substances § 721.644 Amines, C12-14-tert-alkyl, sulfonates. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as amines, C12-14-tert-alkyl, sulfonates (PMN...

  15. 40 CFR 721.644 - Amines, C12-14-tert-alkyl, sulfonates.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Amines, C12-14-tert-alkyl, sulfonates... Substances § 721.644 Amines, C12-14-tert-alkyl, sulfonates. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as amines, C12-14-tert-alkyl, sulfonates (PMN...

  16. The Benefits of Participating in Collaborative Committees.

    ERIC Educational Resources Information Center

    Belfiore, Mary Ellen

    A study was conducted to show the effect that participation in workplace committees has on committee members. The subjects were 34 members of Workplace Education Center (WEC) projects of ABC Canada who work on establishing and maintaining workplace literacy initiatives; they were interviewed by phone or in group discussions. The study found that,…

  17. Potent and Selective Covalent Quinazoline Inhibitors of KRAS G12C

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Zeng, Mei; Lu, Jia; Li, Lianbo

    Targeted covalent small molecules have shown promise for cancers driven by KRAS G12C. Allosteric compounds that access an inducible pocket formed by movement of a dynamic structural element in KRAS, switch II, have been reported, but these compounds require further optimization to enable their advancement into clinical development. We demonstrate that covalent quinazoline-based switch II pocket (SIIP) compounds effectively suppress GTP loading of KRAS G12C, MAPK phosphorylation, and the growth of cancer cells harboring G12C. Notably we find that adding an amide substituent to the quinazoline scaffold allows additional interactions with KRAS G12C, and remarkably increases the labeling efficiency, potency,more » and selectivity of KRAS G12C inhibitors. Structural studies using X-ray crystallography reveal a new conformation of SIIP and key interactions made by substituents located at the quinazoline 2-, 4-, and 7-positions. Optimized lead compounds in the quinazoline series selectively inhibit KRAS G12C-dependent signaling and cancer cell growth at sub-micromolar concentrations.« less

  18. 75 FR 28275 - Homeland Security Science and Technology Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-20

    ... DEPARTMENT OF HOMELAND SECURITY [Docket No. DHS-2010-0020] Homeland Security Science and...; Notice of Closed Federal Advisory Committee Meeting. SUMMARY: On April 12, 2010, the Homeland Security...: The Homeland Security Science and Technology Advisory Committee met on April 20, 2010 from 8:30 a.m...

  19. 76 FR 75912 - Meeting of the Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-05

    ... Joint Board examinations in actuarial mathematics and methodology referred to in 29 U.S.C. 1242(a)(1)(B... Advisory Committee on Actuarial Examinations (portions of which will be open to the public) in Washington.... SUPPLEMENTARY INFORMATION: Notice is hereby given that the Advisory Committee on Actuarial Examinations will...

  20. 78 FR 73564 - Meeting of the Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-06

    ... Joint Board examinations in actuarial mathematics and methodology referred to in 29 U.S.C. 1242(a)(1)(B... Advisory Committee on Actuarial Examinations (portions of which will be open to the public) in Washington.... SUPPLEMENTARY INFORMATION: Notice is hereby given that the Advisory Committee on Actuarial Examinations will...

  1. C-13/C-12 of atmospheric CO2 in the Amazon basin - Forest and river sources

    NASA Technical Reports Server (NTRS)

    Quay, Paul; King, Stagg; Wilbur, Dave; Richey, Jeffrey; Wofsy, Steven

    1989-01-01

    Results are presented of measurements of the CO2 concentrations and C-13/C-12 ratios in CO2 in air samples collected from within the Amazonian rain forest and over the Amazon river between 1982 and 1987. Results indicate the presence of a diurnal cycle in the CO2 concentration and the C-13/C-12 ratio. It was found that the CO2 input to air in the forest was derived from the soil respiration, and the CO2 input to air over the Amazon river was derived from the degassing of CO2 from the river. It was also found that plants growing at heights lower than 7 m assimilate soil-derived CO2 with a low C-13/C-12 ratio.

  2. Actin-associated protein palladin is required for migration behavior and differentiation potential of C2C12 myoblast cells

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Nguyen, Ngoc Uyen Nhi; Liang, Vincent Roderick; Wang, Hao-Ven, E-mail: hvwang@mail.ncku.edu.tw

    2014-09-26

    Highlights: • Palladin is involved in myogenesis in vitro. • Palladin knockdown by siRNA increases myoblast proliferation, viability and differentiation. • Palladin knockdown decreases C2C12 myoblast migration ability. - Abstract: The actin-associated protein palladin has been shown to be involved in differentiation processes in non-muscle tissues. However, but its function in skeletal muscle has rarely been studied. Palladin plays important roles in the regulation of diverse actin-related signaling in a number of cell types. Since intact actin-cytoskeletal remodeling is necessary for myogenesis, in the present study, we pursue to investigate the role of actin-associated palladin in skeletal muscle differentiation. Palladinmore » in C2C12 myoblasts is knocked-down using specific small interfering RNA (siRNA). The results show that down-regulation of palladin decreased migratory activity of mouse skeletal muscle C2C12 myoblasts. Furthermore, the depletion of palladin enhances C2C12 vitality and proliferation. Of note, the loss of palladin promotes C2C12 to express the myosin heavy chain, suggesting that palladin has a role in the modulation of C2C12 differentiation. It is thus proposed that palladin is required for normal C2C12 myogenesis in vitro.« less

  3. Interleukin-12 (-1188) A/C and interferon-γ (+874) A/T gene polymorphisms in subacute sclerosing panencephalitis patients.

    PubMed

    Dundar, Nihal Olgac; Gencpinar, Pinar; Sallakci, Nilgun; Duman, Ozgur; Haspolat, Senay; Anlar, Banu; Yegin, Olcay

    2016-10-01

    The two polymorphisms [IL-12 (-1188) A/C and the IFN-γ (+874) A/T)] are known to have functional consequences and henceforth were analyzed in subacute sclerosing panencephalitis (SSPE) patients to reveal a possible relation with these polymorphisms and this debilitating disease. For the IL-12 (-1188) A/C polymorphism, 78 patients and 90 healthy individuals were analyzed. An increase in the AA genotype was determined (p = 0.02, OR = 2.06). There was also a statistically significant difference between the control group and the patients with respect to the allele frequencies (p = 0.04, OR = 1.65). For the IFN-γ (+874) A/T polymorphism, 69 SSPE patients and 115 controls were studied and there was not a significant difference between the two groups. Our findings suggested that not the IFN-γ (+874) A/T but the IL-12 (-1188) A/C polymorphism is correlated with SSPE and having an AA genotype or A allele decreases the risk of developing SSPE by 2.06- and 1.65-fold, respectively.

  4. 75 FR 18145 - Eastern Arizona Counties Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-09

    ... DEPARTMENT OF AGRICULTURE Forest Service Eastern Arizona Counties Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Eastern Arizona Counties Resource... Rivera, Coordinator, Eastern Arizona Counties Resource Advisory Committee, c/o Forest Service, USDA, P.O...

  5. 75 FR 4589 - NASA Advisory Council Exploration Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-28

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (10-012)] NASA Advisory Council Exploration... Aeronautics and Space Administration announces a meeting of the NASA Advisory Council Exploration Committee... Parham, Exploration Committee Administrative Officer, Mail Stop 7C27, National Aeronautics and Space...

  6. 75 FR 81644 - Hearing of The Judicial Conference Committee on Criminal Rules

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-28

    ... San Francisco, CA FOR FURTHER INFORMATION CONTACT: Peter G. McCabe, Secretary, Rules Committee Support.... Dated: December 21, 2010. Peter G. McCabe, Rules Committee Support Office. [FR Doc. 2010-32415 Filed 12...

  7. Role of androgen receptor on cyclic mechanical stretch-regulated proliferation of C2C12 myoblasts and its upstream signals: IGF-1-mediated PI3K/Akt and MAPKs pathways.

    PubMed

    Ma, Yiming; Fu, Shaoting; Lu, Lin; Wang, Xiaohui

    2017-07-15

    To detect the effects of androgen receptor (AR) on cyclic mechanical stretch-modulated proliferation of C2C12 myoblasts and its pathways: roles of IGF-1, PI3K and MAPK. C2C12 were randomly divided into five groups: un-stretched control, six or 8 h of fifteen percent stretch, and six or 8 h of twenty percent stretch. Cyclic mechanical stretch of C2C12 were completed using a computer-controlled FlexCell Strain Unit. Cell proliferation and IGF-1 concentration in medium were detected by CCK8 and ELISA, respectively. Expressions of AR and IGF-1R, and expressions and activities of PI3K, p38 and ERK1/2 in stretched C2C12 cells were determined by Western blot. ①The proliferation of C2C12 cells, IGF-1 concentration in medium, expressions of AR and IGF-1R, and activities of PI3K, p38 and ERK1/2 were increased by 6 h of fifteen percent stretch, while decreased by twenty percent stretch for six or 8 h ②The fifteen percent stretch-increased proliferation of C2C12 cells was reversed by AR inhibitor, Flutamide. ③The increases of AR expression, activities of PI3K, p38 and ERK1/2 resulted from fifteen percent stretch were attenuated by IGF-1 neutralizing antibody, while twenty percent stretch-induced decreases of the above indicators were enhanced by recombinant IGF-1. ④Specific inhibitors of p38, ERK1/2 and PI3K all decreased the expression of AR in fifteen percent and twenty percent of stretched C2C12 cells. Cyclic mechanical stretch modulated the proliferation of C2C12 cells, which may be attributed to the alterations of AR via IGF-1-PI3K/Akt and IGF-1-MAPK (p38, ERK1/2) pathways in C2C12 cells. Copyright © 2017 Elsevier B.V. All rights reserved.

  8. Synthesis of 1,2-cis-2-C-branched aryl-C-glucosides via desulfurization of carbohydrate based hemithioacetals

    PubMed Central

    Mebrahtu, Fanuel M; Manana, Mandlenkosi M; Madumo, Kagiso; Sokamisa, Mokela S

    2015-01-01

    Summary 1-C and 2-C-branched carbohydrates are present as substructures in a number of biologically important compounds. Although the synthesis of such carbohydrate derivatives is extensively studied, the synthesis of 1,2-cis-2-C-branched C-, S-, and N-glycosides is less explored. In this article a synthetic strategy for the synthesis of 1,2-cis-2-C-branched-aryl-C-glucosides is reported via a hydrogenolytic desulfurization of suitably orientated carbohydrate based hemithioacetals. 1,2-cis-2-Hydroxymethyl and 2-carbaldehyde of aryl-C-glucosides have been synthesized using the current strategy in very good yields. The 2-carbaldehyde-aryl-C-glucosides have been identified as suitable substrates for the stereospecific preparation of 2,3-unsaturated-aryl-C-glycosides (Ferrier products). PMID:26124859

  9. 77 FR 9705 - NASA Advisory Council; Technology and Innovation Committee; Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-17

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice 12-013] NASA Advisory Council; Technology and Innovation Committee; Meeting AGENCY: National Aeronautics and Space Administration. ACTION... and Innovation Committee of the NASA Advisory Council (NAC). DATES: Tuesday, March 6, 2012, 8 a.m. to...

  10. Assignment of xeroderma pigmentosum group C(XPC) gene to chromosome 3p25

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Legerski, R.J.; Liu, P.; Li, L.

    1994-05-01

    The human gene XPC (formerly designated XPCC), which corrects the repair deficiency of xeroderma pigmentosum (XP) group C cells, was mapped to 3p25. A cDNA probe for Southern blot hybridization and diagnostic PCR analyses of hybrid clone panels informative for human chromosomes in general and portions of chromosome 3 in particular produced the initial results. Fluorescence in situ hybridization utilizing both a yeast artificial chromosome DNA containing the gene and XPC cDNA as probes provided verification and specific regional assignment. A conflicting assignment of XPC to chromosome 5 is discussed in light of inadequacies in the exclusive use of microcell-mediatedmore » chromosome transfer for gene mapping. 12 refs., 3 figs.« less

  11. 78 FR 51197 - DHS Data Privacy and Integrity Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-20

    ... DEPARTMENT OF HOMELAND SECURITY Office of the Secretary [Docket No. DHS-2013-0055] DHS Data... of Federal Advisory Committee Meeting. SUMMARY: The DHS Data Privacy and Integrity Advisory Committee will meet on September 12, 2013, in Washington, DC. The meeting will be open to the public. DATES: The...

  12. Line Positions and Intensities for the ν12 Band of 13C12CH_6

    NASA Astrophysics Data System (ADS)

    Devi, V. Malathy; Benner, D. Chris; Sung, Keeyoon; Crawford, Timothy J.; Mantz, Arlan; Smith, Mary Ann H.

    2014-06-01

    High-resolution, high signal-to-noise spectra of mono-substituted 13C-ethane (13C12CH_6) in the 12.2 μm region were recorded with a Bruker IFS 125HR Fourier transform spectrometer. The spectra were obtained for four sample pressures at three different temperatures between 130 and 208 K using a 99% 13C-enriched ethane sample contained in a 20.38-cm long coolable absorption cell. A multispectrum nonlinear least squares fitting technique was used to fit the same intervals in the four spectra simultaneously to determine line positions and intensities. Similar to our previous analyses of 12C_2H_6 spectra in this same region, constraints were applied to accurately fit each pair of doublet components arising from torsional Coriolis interaction of the excited ν12 = 1 state with the nearby torsional ν_6 = 3 state. Line intensities corresponding to each spectrum temperature (130 K, 178 K and 208 K) are reported for 1660 ν12 absorption lines for which the assignments are known, and integrated intensities are estimated as the summation of the measured values. The measured line positions and intensities (re-scaled to 296 K) are compared with values in recent editions of spectroscopic databases. K. Sung, A. W. Mantz, L. R. Brown, et al., J. Mol. Spectrosc., 162 (2010) 124-134. D. C. Benner, C. P. Rinsland, V. Malathy Devi, M. A. H. Smith and D. Atkins, JQSRT, 53 (1995) 705-721. V. Malathy Devi, C. P. Rinsland, D. Chris Benner, et al., JQSRT, 111 (2010) 1234-1251 V. Malathy Devi, D. Chris Benner, C. P. Rinsland, et al., JQSRT, 111 (2010) 2481-2504. Research described in this paper was performed at Connecticut College, the College of William and Mary, NASA Langley Research Center and the Jet Propulsion Laboratory, California Institute of Technology, under contracts and cooperative agreements with the National Aeronautics and Space Administration.

  13. 75 FR 3501 - Advisory Committee on Reactor Safeguards

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-21

    ... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards In accordance with the purposes of Sections 29 and 182b of the Atomic Energy Act (42 U.S.C. 2039, 2232b), the Advisory Committee on Reactor Safeguards (ACRS) will hold a meeting on February 4-6, 2010, 11545 Rockville Pike...

  14. 12 CFR 271.6 - Processing requests.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... ten working days of receipt of the request. In exceptional situations, the Secretary of the Committee... Committee, 20th and C Street, N.W., Washington, D.C. 20551; or sent by facsimile to the Secretary of the...

  15. 40 CFR 180.1068 - C12-C18 fatty acid potassium salts; exemption from the requirement of a tolerance.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false C12-C18 fatty acid potassium salts... RESIDUES IN FOOD Exemptions From Tolerances § 180.1068 C12-C18 fatty acid potassium salts; exemption from the requirement of a tolerance. C12-C18 fatty acids (saturated and unsaturated) potassium salts are...

  16. 40 CFR 180.1068 - C12-C18 fatty acid potassium salts; exemption from the requirement of a tolerance.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 25 2013-07-01 2013-07-01 false C12-C18 fatty acid potassium salts... RESIDUES IN FOOD Exemptions From Tolerances § 180.1068 C12-C18 fatty acid potassium salts; exemption from the requirement of a tolerance. C12-C18 fatty acids (saturated and unsaturated) potassium salts are...

  17. 40 CFR 180.1068 - C12-C18 fatty acid potassium salts; exemption from the requirement of a tolerance.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 25 2012-07-01 2012-07-01 false C12-C18 fatty acid potassium salts... RESIDUES IN FOOD Exemptions From Tolerances § 180.1068 C12-C18 fatty acid potassium salts; exemption from the requirement of a tolerance. C12-C18 fatty acids (saturated and unsaturated) potassium salts are...

  18. 40 CFR 180.1068 - C12-C18 fatty acid potassium salts; exemption from the requirement of a tolerance.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 24 2011-07-01 2011-07-01 false C12-C18 fatty acid potassium salts... RESIDUES IN FOOD Exemptions From Tolerances § 180.1068 C12-C18 fatty acid potassium salts; exemption from the requirement of a tolerance. C12-C18 fatty acids (saturated and unsaturated) potassium salts are...

  19. 40 CFR 180.1068 - C12-C18 fatty acid potassium salts; exemption from the requirement of a tolerance.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 24 2014-07-01 2014-07-01 false C12-C18 fatty acid potassium salts... RESIDUES IN FOOD Exemptions From Tolerances § 180.1068 C12-C18 fatty acid potassium salts; exemption from the requirement of a tolerance. C12-C18 fatty acids (saturated and unsaturated) potassium salts are...

  20. 78 FR 58612 - Genomic Medicine Program Advisory Committee, Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-24

    ... DEPARTMENT OF VETERANS AFFAIRS Genomic Medicine Program Advisory Committee, Notice of Meeting The Department of Veterans Affairs (VA) gives notice under the Federal Advisory Committee Act, 5 U.S.C. App. 2, that the Genomic Medicine Program Advisory Committee will meet on October 16, 2013, at the Sheraton...

  1. Ribbon structure stabilized by C10 and C12 turns in αγ hybrid peptide.

    PubMed

    Wani, Naiem Ahmad; Kant, Rajni; Gupta, Vivek Kumar; Aravinda, Subrayashastry; Rai, Rajkishor

    2016-04-01

    The present study describes the synthesis and crystallographic analysis of αγ hybrid peptides, Boc-Gpn-L-Pro-NHMe (1), Boc-Aib-Gpn-L-Pro-NHMe (2), and Boc-L-Pro-Aib-Gpn-L-Pro-NHMe (3). Peptides 1 and 2 adopt expanded 12-membered (C12 ) helical turn over γα segment. Peptide 3 promotes the ribbon structure stabilized by type II β-turn (C10 ) followed by the expanded C12 helical γα turn. Both right-handed and left-handed helical conformations for Aib residue are observed in peptides 2 and 3, respectively. Copyright © 2016 European Peptide Society and John Wiley & Sons, Ltd.

  2. 75 FR 59326 - Eighth Meeting-RTCA Special Committee 220: Automatic Flight Guidance and Control

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-27

    ... Committee 220: Automatic Flight Guidance and Control AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of RTCA Special Committee 220: Automatic Flight Guidance and Control meeting. SUMMARY: The... Flight Guidance and Control. DATES: The meeting will be held October 12-14, 2010. October 12th and 13th...

  3. Synthesis of new C-25 and C-26 steroidal acids as potential ligands of the nuclear receptors DAF-12, LXR and GR.

    PubMed

    Dansey, María V; Del Fueyo, María C; Veleiro, Adriana S; Di Chenna, Pablo H

    2017-05-01

    A new methodology to obtain C-25 and C-26 steroidal acids starting from pregnenolone is described. Construction of the side chain was achieved by applying the Mukaiyama aldol reaction with a non-hydrolytic work-up to isolate the trapped silyl enol ether with higher yields. Using this methodology we synthesized three new steroidal acids as potential ligands of DAF-12, Liver X and Glucocorticoid nuclear receptors and studied their activity in reporter gene assays. Our results show that replacement of the 21-CH 3 by a 20-keto group in the side chains of the cholestane scaffold of DAF-12 or Liver X receptors ligands causes the loss of the activity. Copyright © 2017 Elsevier Inc. All rights reserved.

  4. OCLC and Its Advisory Committees.

    ERIC Educational Resources Information Center

    Baker, Shirley K.

    1998-01-01

    Describes the Online Computer Library Center (OCLC) advisory committees in terms of research, public, college and university, and special libraries. All four of the type-of-library advisory groups work to shape OCLC policies and programs, according to the particular needs of each group. OCLC's financial and programmatic success depends upon…

  5. A Boron Protecting Group Strategy for 1,2-Azaborines.

    PubMed

    Baggett, Andrew W; Liu, Shih-Yuan

    2017-10-25

    Upon reaction with either molecular oxygen or di-tert-butylperoxide in the presence of a simple copper(I) salt and an alcohol, a range of 1,2-azaborines readily exchange B-alkyl or B-aryl moieties for B-alkoxide fragments. This transformation allows alkyl and aryl groups to serve for the first time as removable protecting groups for the boron position of 1,2-azaborines during reactions that are not compatible with the easily modifiable B-alkoxide moiety. This reaction can be applied to synthesize a previously inaccessible BN isostere of ethylbenzene, a compound of interest in biomedical research. A sequence of epoxide ring opening using N-deprotonated 1,2-azaborines followed by an intramolecular version of the boron deprotection reaction can be applied to access the first examples of BN isosteres of dihydrobenzofurans and benzofurans, classes of compounds that are important to medicinal chemistry and natural product synthesis.

  6. 77 FR 5041 - National Offshore Safety Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-01

    ... recommendations on (1) the Diving Subcommittee and Task Statement to Study the Matter of Medical Treatment of... and recommendations on: (a) Diving Sub-committee and Task Statement to Study the Matter of Medical... Advisory Committee Act (FACA), 5 U.S.C. App. (Pub. L. 92-463). NOSAC provides advice and recommendations to...

  7. 78 FR 18679 - Advisory Committee on Women Veterans, Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-27

    ... DEPARTMENT OF VETERANS AFFAIRS Advisory Committee on Women Veterans, Notice of Meeting The Department of Veterans Affairs (VA) gives notice under the Federal Advisory Committee Act, 5 U.S.C. App. 2., that the Advisory Committee on Women Veterans will meet on April 9-11, 2013, in the G. V. ``Sonny...

  8. Folding model analyses of 12C-12C and 16O-16O elastic scattering using the density-dependent LOCV-averaged effective interaction

    NASA Astrophysics Data System (ADS)

    Rahmat, M.; Modarres, M.

    2018-03-01

    The averaged effective two-body interaction (AEI), which can be generated through the lowest order constrained variational (LOCV) method for symmetric nuclear matter (SNM) with the input [Reid68, Ann. Phys. 50, 411 (1968), 10.1016/0003-4916(68)90126-7] nucleon-nucleon potential, is used as the effective nucleon-nucleon potential in the folding model to describe the heavy-ion (HI) elastic scattering cross sections. The elastic scattering cross sections of 12C-12C and 16O-16O systems are calculated in the above framework. The results are compared with the corresponding calculations coming from the fitting procedures with the input finite range D D M 3 Y 1 -Reid potential and the available experimental data at different incident energies. It is shown that a reasonable description of the elastic 12C-12C and 16O-16O scattering data at the low and medium energies can be obtained by using the above LOCV AEI, without any need to define a parametrized density-dependent function in the effective nucleon-nucleon potential, which is formally considered in the typical D D M 3 Y 1 -Reid interactions.

  9. Committees

    NASA Astrophysics Data System (ADS)

    2012-11-01

    Leadership Team of the IAHR Committee for Hydraulic Machinery and Systems Eduard EGUSQUIZA, UPC Barcelona, Spain, Chair François AVELLAN, EPFL-LMH, Switzerland, Past Chair Richard K FISHER, Voith Hydro Inc., USA, Past Chair Fidel ARZOLA, Edelca, Venezuela Michel COUSTON, Alstom Hydro, France Niklas DAHLBÄCKCK, Vatenfall, Sweden Normand DESY, Andritz VA TECH Hydro Ltd., Canada Chisachi KATO, University of Tokyo, Japan Andrei LIPEJ, Turboinstitut, Slovenija Torbjørn NIELSEN, NTNU, Norway Romeo SUSAN-RESIGA, 'Politehnica' University Timisoara, Romania Stefan RIEDELBAUCH, Stuggart University, Germany Albert RUPRECHT, Stuttgart University, Germany Qing-Hua SHI, Dong Fang Electrical Machinery Co., China Geraldo TIAGO, Universidade Federal de Itajubá, Brazil International Advisory Committee Shouqi YUAN (principal) Jiangsu University China QingHua SHI (principal) Dong Fang Electrical Machinery Co. China Fidel ARZOLA EDELCA Venezuela Thomas ASCHENBRENNER Voith Hydro GmbH & Co. KG Germany Anton BERGANT Litostroj Power doo Slovenia B C BHAOYAL Research & Technology Centre India Hermod BREKKE NTNU Norway Stuart COULSON Voith Hydro Inc. USA Paul COOPER Fluid Machinery Research Inc USA V A DEMIANOV Power Machines OJSC Russia Bart van ESCH Technische Universiteit Eindhoven Netherland Arno GEHRER Andritz Hydro Graz Austria Akira GOTO Ebara Corporation Japan Adiel GUINZBURG The Boeing Company USA D-H HELLMANN KSB AG Germany Ashvin HOSANGADI Combustion Research and Flow Technology USA Byung-Sun HWANG Korea Institute of Material Science Korea Toshiaki KANEMOTO Kyushu Institute of Technology Japan Mann-Eung KIM Korean Register of Shipping Korea Jiri KOUTNIK Voith Hydro GmbH & Co. KG Germany Jinkook LEE Eaton Corporation USA Young-Ho LEE Korea Maritime University Korea Woo-Seop LIM Hyosung Goodsprings Inc Korea Jun MATSUI Yokohama National University Japan Kazuyoshi Mitsubishi H I Ltd, Japan MIYAGAWA Christophe NICOLET Power Vision Engineering Srl Switzerland Maryse PAGE Hydro

  10. 78 FR 17086 - Public Hearing Before a Public Advisory Committee; Technical Amendments

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-20

    ... Administrative practice and procedure, Advisory committees, Color additives, Drugs, Foods, Medical Devices... device good manufacturing practice advisory committees established under section 520(f)(3) of the FD&C...) Color additive advisory committees are required to be established under the circumstances specified in...

  11. 75 FR 80082 - State, Local, Tribal, and Private Sector Policy Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-21

    ... NATIONAL ARCHIVES AND RECORDS ADMINISTRATION State, Local, Tribal, and Private Sector Policy Advisory Committee AGENCY: National Archives and Records Administration. ACTION: Notice of Establishment of a NARA Advisory Committee, Pursuant to the Federal Advisory Committee Act, 5 U.S.C. Appendix 2 and...

  12. 77 FR 59888 - General Conference Committee of the National Poultry Improvement Plan

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-01

    ... Inspection Service [Docket No. APHIS-2012-0068] General Conference Committee of the National Poultry... the General Conference Committee of the National Poultry Improvement Plan (Committee) for a 2year... interest. FOR FURTHER INFORMATION CONTACT: Dr. C. Stephen Roney, Senior Coordinator, National Poultry...

  13. 44 CFR 12.18 - Uniform pay guidelines.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Uniform pay guidelines. 12.18... HOMELAND SECURITY GENERAL ADVISORY COMMITTEES § 12.18 Uniform pay guidelines. (a) Members. Subject to the provisions of this section, the pay of any member of an advisory committee shall be fixed at the daily...

  14. Update Of The ACR-NEMA Standard Committee

    NASA Astrophysics Data System (ADS)

    Wang, Yen; Best, D. E.; Morse, R. R.; Horii, S. C.; Lehr, J. L.; Lodwick, G. S.; Fuscoe, C.; Nelson, O. L.; Perry, J. R.; Thompson, B. G.; Wessell, W. R.

    1988-06-01

    In January, 1984, the American College of Radiology (ACR) representing the users of imaging equipment and the National Electrical Manufacturers Association (NEMA) representing the manufacturers of imaging equipment joined forces to create a committee that could solve the compatibility issues surrounding the exchange of digital medical images. This committee, the ACR-NEMA Digital Imaging and Communication Standards Committee was composed of radiologists and experts from industry who addressed the problems involved in interfacing different digital imaging modalities. In just two years, the committee and three of its working groups created an industry standard interface, ACR-NEMA Digital Imaging and Communications Standard, Publication No. 300-1985. The ACR-NEMA interface allows digital medical images and related information to be communicated between different imaging devices, regardless of manufacturer or use of differing image formats. The interface is modeled on the International Standards Organization's Open Systems Interconnection sever-layer reference model. It is believed that the development of the Interface was the first step in the development of standards for Medical Picture Archiving and Communications Systems (PACS). Developing the interface Standard has required intensive technical analysis and examination of the future trends for digital imaging in order to design a model which would not be quickly outmoded. To continue the enhancement and future development of image management systems, various working groups have been created under the direction of the ACR-NEMA Committee.

  15. Developmental Changes is Expression of Beta-Adrenergic Receptors in Cultures of C2C12 Skeletal Muscle Cells

    NASA Technical Reports Server (NTRS)

    Young, Ronald B.; Bridge, K. Y.; Vaughn, J. R.

    2000-01-01

    beta-Adrenergic receptor (bAR) agonists have been reported to modulate growth in several mammalian and avian species, and bAR agonists presumably exert their physiological action on skeletal muscle cells through this receptor. Because of the importance of bAR regulation on muscle protein metabolism in muscle cells, the objectives of this study were to determine the developmental expression pattern of the bAR population in C2C12 skeletal muscle cells, and to analyze changes in both the quantity and isoform expression of the major muscle protein, myosin. The number of bAR in mononucleated C2C12 cells was approximately 8,000 bAR per cell, which is comparable with the population reported in several other nonmuscle cell types. However, the bar population increased after myoblast fusion to greater than 50,000 bAR per muscle cell equivalent. The reasons for this apparent over-expression of bAR in C2C12 cells is not known. The quantity of myosin also increased after C2C12 myoblast fusion, but the quantity of myosin was less than that reported in primary muscle cell cultures. Finally, at least five different isoforms of myosin heavy chain could be resolved in C2C12 cells, and three of these exhibited either increased or decreased developmental regulation relative to the others. Thus, C2C12 myoblasts undergo developmental regulation of bAR population and myosin heavy chain isoform expression.

  16. 75 FR 80059 - Advisory Committees; Tentative Schedule of Meetings for 2011

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-21

    ... BIOLOGICS EVALUATION AND RESEARCH Allergenic Products Advisory Committee. May 12. Blood Products Advisory... Advisory Committee. September 20-21, November 16- 17. CENTER FOR DRUG EVALUATION AND RESEARCH Anesthetic... Gynecology Devices Panel May 19-20, September 22-23. Ophthalmic Devices Panel February 18. Orthopedic and...

  17. 77 FR 63831 - Consumer Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-17

    ... from its Disability Working Group concerning updating of the Commission's rules regarding Speech-to... recommendation for the Committee's consideration, also proposed by its Disability Working Group, urges the Commission to include people with disabilities, low income, and underserved populations in its Mobile Health...

  18. 78 FR 1917 - Commercial Space Transportation Advisory Committee-Public Teleconference

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-09

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Commercial Space Transportation...: Notice of Commercial Space Transportation Advisory Committee Teleconference. SUMMARY: Pursuant to the... Group (BLWG) of the Commercial Space Transportation Advisory Committee (COMSTAC). DATES: The...

  19. Biomedical Challenges Presented by the American Indian, Proceedings of the Special Session of the PAHO Advisory Committee on Medical Research (7th, Washington, D.C., June 25, 1968).

    ERIC Educational Resources Information Center

    Pan American Health Organization, Washington, DC.

    At each meeting of the Pan American Health Organization Advisory Committee on Medical Research, a special 1-day session is held on a topic chosen by the committee as being of particular interest. At the 7th meeting, which convened in June of 1968 in Washington, D.C., the session surveyed the origin, present distribution, and principal biological…

  20. A microplate assay for measuring cell death in C2C12 cells.

    PubMed

    Lima, Tanes; Silveira, Leonardo

    2018-03-22

    The main goal of this study was to develop a straightforward and rapid microplate assay for measuring propidium iodide (PI) in C2C12 cells. The PI method proves to be an efficient quantitative assay for analyzing cell viability through PI fluorescence analysis. Importantly, the protocol takes less than 30 minutes, and the results are reproducible. C2C12 cells were exposed to an increasing concentration of palmitate for a period of 24 hours to induce cell death, and the PI fluorescence increased in a concentration-dependent manner. Evaluation of mitochondrial function and reactive oxygen species production validated the deleterious effects of palmitate treatment. Also, the microplate PI assay demonstrated high sensitivity as indicated by the detection of modest fluctuations in cell viability in response to catalase overexpression in palmitate-treated cells. The microplate PI assay, therefore, offers an accurate method to be used for in vitro studies.

  1. Ethics consultants and ethics committees.

    PubMed

    La Puma, J; Toulmin, S E

    1989-05-01

    To address moral questions in patient care, hospitals and health care systems have enlisted the help of hospital ethicists, ethics committees, and ethics consultation services. Most physicians have not been trained in the concepts, skills, or language of clinical ethics, and few ethicists have been trained in clinical medicine, so neither group can fully identify, analyze, and resolve clinical ethical problems. Some ethics committees have undertaken clinical consultations themselves, but liability concerns and variable standards for membership hinder their efforts. An ethics consultation service comprising both physician-ethicists and nonphysician-ethicists brings complementary viewpoints to the management of particular cases. If they are to be effective consultants, however, nonphysician-ethicists need to be "clinicians": professionals who understand an individual patient's medical condition and personal situation well enough to help in managing the case. Ethics consultants and ethics committees may work together, but they have separate identities and distinct objectives: ethics consultants are responsible for patient care, while ethics committees are administrative bodies whose primary task is to advise in creating institutional policy.

  2. 76 FR 39859 - Notice of Federal Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-07

    ... Threat Reduction Advisory Committee (Hereafter referred to as ``the Committee''). 1. Purpose of Meeting... technology security, combating weapons of mass destruction (WMD), counter terrorism and counter proliferation... discussions on WMD related national security matters. 3. Meeting Accessibility: Pursuant to 5 U.S.C. 552b, as...

  3. 76 FR 45504 - Prince of Wales Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-29

    ... DEPARTMENT OF AGRICULTURE Forest Service Prince of Wales Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Prince of Wales Resource Advisory Committee.... Written comments and requests for time for oral comments must be sent to Prince of Wales RAC c/o District...

  4. Alpha particle condensation in {sup 12}C and nuclear rainbow scattering

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ohkubo, S.; Hirabayashi, Y.

    2008-05-12

    It is shown that the large radius of the Hoyle state of {sup 12}C with a dilute density distribution in an {alpha} particle condensate can be clearly seen in the shift of the rainbow angle (therefore the Airy minimum) to a larger angle in {alpha}+{sup 12}C rainbow scattering at the high energy region and prerainbow oscillations in {sup 3}He+{sup 12}C scattering at the lower energy region.

  5. Youth Voice in Nigerian School-Based Management Committees

    ERIC Educational Resources Information Center

    Umar, Bashiru Bako; Krauss, Steven Eric; Samah, Asnarulkhadi Abu; Hamid, Jamaliah Abdul

    2017-01-01

    In Nigeria, School-Based Management Committees (SBMCs) aim to provide an opportunity for all stakeholders, particularly the vulnerable groups in the school's host communities such as young people and women to partake in school governance. Research on the experiences of youth voice in the committees is scant, however, as much of the existing…

  6. YF-12A and YF-12C in flight formation at dawn

    NASA Technical Reports Server (NTRS)

    1975-01-01

    The YF-12A (60-6935) carries the 'coldwall' heat transfer pod on a pylon beneath the forward fuselage. The pod is seen with its insulating coating intact. In the background, the YF-12C flies photo chase. The coldwall project, supported by Langley Research Center, consisted of a stainless steel tube equipped with thermocouples and pressure-sensors. A special insulating coating covered the tube, which was chilled with liquid nitrogen. At Mach 3, the insulation could be pyrotechnically blown away from the tube, instantly exposing it to the thermal environment. The experiment caused many inflight difficulties, such as engine unstarts, but eventually researchers got a successful flight. The Flight Research Center's involvement with the YF-12A, an interceptor version of the Lockheed A-12, began in 1967. Ames Research Center was interested in using wind tunnel data that had been generated at Ames under extreme secrecy. Also, the Office of Advanced Research and Technology (OART) saw the YF-12A as a means to advance high-speed technology, which would help in designing the Supersonic Transport (SST). The Air Force needed technical assistance to get the latest reconnaissance version of the A-12 family, the SR-71A, fully operational. Eventually, the Air Force offered NASA the use of two YF-12A aircraft, 60-6935 and 60-6936. A joint NASA-USAF program was mapped out in June 1969. NASA and Air Force technicians spent three months readying 935 for flight. On 11 December 1969, the flight program got underway with a successful maiden flight piloted by Col. Joe Rogers and Maj. Gary Heidelbaugh of the SR-71/F-12 Test Force. During the program, the Air Force concentrated on military applications, and NASA pursued a loads research program. NASA studies included inflight heating, skin-friction cooling, 'coldwall' research (a heat transfer experiment), flowfield studies, shaker vane research, and tests in support of the Space Shuttle landing program. Ultimately, 935 became the workhorse

  7. 11 CFR 109.10 - How do political committees and other persons report independent expenditures?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 11 Federal Elections 1 2010-01-01 2010-01-01 false How do political committees and other persons... SEC. 214(c)) Independent Expenditures § 109.10 How do political committees and other persons report independent expenditures? (a) Political committees, including political party committees, must report...

  8. 77 FR 69900 - Advisory Committee on Reactor Safeguards; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-21

    ... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards; Notice of Meeting In... Advisory Committee on Reactor Safeguards (ACRS) will hold a meeting on December 6-8, 2012, 11545 Rockville... Recommendations (SECY-12-0064), (3) Venting Systems for Boiling Water Reactors (BWRs) with Mark I and Mark II...

  9. Delayed Generalized Necrotic Purpuric Rash in a C6-Deficient 12-Year-Old Girl Treated for Group W Meningococcal Disease.

    PubMed

    Gaschignard, Jean; Hassani, Nailati; El Sissy, Carine; Bonacorsi, Stéphane; Dauger, Stéphane; Chomton, Maryline; Taha, Muhamed-Kheir; Levy, Michael

    2018-02-22

    We report an unusual case of generalized necrotic purpuric rash that started 48 hours after the initiation of effective third-generation cephalosporin therapy to treat Neisseria meningitidis W infection in a 12-year-old girl. The course was favorable with no shock, and she recovered completely without sequelae. This infection revealed C6 deficiency in our patient.

  10. Determinants of 12-step group affiliation and moderators of the affiliation-abstinence relationship.

    PubMed

    Timko, Christine; Billow, Rachel; DeBenedetti, Anna

    2006-06-28

    This study examined characteristics of substance use disorder (SUD) outpatients at intake to treatment (N=345) that were associated with more 12-step group attendance and involvement, Steps worked, and acceptance of 12-step philosophy at a 6-month follow-up (N=281, 81.4%). Patient characteristics covered the domains of sociodemographics, SUD severity, personal functioning, and previous help received. Distinguishing baseline characteristics of patients who attended more 12-step group meetings during follow-up were being less-educated, more engaged in religious practices, and more extroverted and interpersonally competent, and having had more previous 12-step group exposure. These patient characteristics were generally similar to those associated with more 12-step meeting involvement and philosophy acceptance. More 12-step meeting attendance and involvement were related to abstinence at 6 months. Associations of attendance with abstinence were stronger among patients who were younger, white, less-educated, unstably employed, less religious, and less interpersonally skilled. These patients may have had fewer available social resources and so benefitted more from the fellowship and support for abstinence that 12-step group members often provide. We suggest methods by which treatment providers may encourage 12-step group affiliation among patients likely to benefit from it on substance use outcomes.

  11. 78 FR 24239 - Advisory Committee for Engineering; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-24

    ... NATIONAL SCIENCE FOUNDATION Advisory Committee for Engineering; Notice of Meeting In accordance with Federal Advisory Committee Act (Pub. L. 92-463, as amended), the National Science Foundation... Engineering (1115). Date/Time: May 16, 2013: 12:30 p.m. to 5:30 p.m., May 17, 2013: 8:30 a.m. to 2:00 p.m...

  12. Enhancement of Palmarumycins C(12) and C(13) production in liquid culture of endophytic fungus Berkleasmium sp. Dzf12 after treatments with metal ions.

    PubMed

    Mou, Yan; Luo, Haiyu; Mao, Ziling; Shan, Tijiang; Sun, Weibo; Zhou, Kaiyi; Zhou, Ligang

    2013-01-07

    The influences of eight metal ions (i.e., Na+, Ca2+, Ag+, Co2+, Cu2+, Al3+, Zn2+, and Mn4+) on mycelia growth and palmarumycins C(12) and C(13) production in liquid culture of the endophytic fungus Berkleasmium sp. Dzf12 were investigated. Three metal ions, Ca2+, Cu2+ and Al3+ were exhibited as the most effective to enhance mycelia growth and palmarumycin production. When calcium ion (Ca2+) was applied to the medium at 10.0 mmol/L on day 3, copper ion (Cu2+) to the medium at 1.0 mmol/L on day 3, aluminum ion (Al3+) to the medium at 2.0 mmol/L on day 6, the maximal yields of palmarumycins C(12) plus C(13) were obtained as 137.57 mg/L, 146.28 mg/L and 156.77 mg/L, which were 3.94-fold, 4.19-fold and 4.49-fold in comparison with that (34.91 mg/L) of the control, respectively. Al3+ favored palmarumycin C(12) production when its concentration was higher than 4 mmol/L. Ca2+ had an improving effect on mycelia growth of Berkleasmium sp. Dzf12. The combination effects of Ca2+, Cu2+ and Al3+ on palmarumycin C(13) production were further studied by employing a statistical method based on the central composite design (CCD) and response surface methodology (RSM). By solving the quadratic regression equation between palmarumycin C(13) and three metal ions, the optimal concentrations of Ca2+, Cu2+ and Al3+ in medium for palmarumycin C(13) production were determined as 7.58, 1.36 and 2.05 mmol/L, respectively. Under the optimum conditions, the predicted maximum palmarumycin C(13) yield reached 208.49 mg/L. By optimizing the combination of Ca2+, Cu2+ and Al3+ in medium, palmarumycin C(13) yield was increased to 203.85 mg/L, which was 6.00-fold in comparison with that (33.98 mg/L) in the original basal medium. The results indicate that appropriate metal ions (i.e., Ca2+, Cu2+ and Al3+) could enhance palmarumycin production. Application of the metal ions should be an effective strategy for palmarumycin production in liquid culture of the endophytic fungus Berkleasmium sp. Dzf12.

  13. The Investment Committee. AGB Effective Committee Series

    ERIC Educational Resources Information Center

    Yoder, Jay A.

    2011-01-01

    This publication is part of an AGB series devoted to strengthening the role of key standing committees of governing boards. While there is no optimum committee system for institutions of higher education, certain principles, practices, and procedures prevail. The best practices included in this text support the objectives of board committees:…

  14. 29 CFR 1912a.12 - Charter.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) NATIONAL ADVISORY COMMITTEE ON OCCUPATIONAL SAFETY AND HEALTH § 1912a.12 Charter. The Committee shall... enactment of the Occupational Safety and Health Act. ...

  15. 29 CFR 1912a.12 - Charter.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) NATIONAL ADVISORY COMMITTEE ON OCCUPATIONAL SAFETY AND HEALTH § 1912a.12 Charter. The Committee shall... enactment of the Occupational Safety and Health Act. ...

  16. 7 CFR 7.8 - Conduct of community committee elections.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Conduct of community committee elections. 7.8 Section 7.8 Agriculture Office of the Secretary of Agriculture SELECTION AND FUNCTIONS OF AGRICULTURAL... any other purpose. (c) The county committee shall give advance public notice of how, when, and where...

  17. 76 FR 24852 - Prince of Wales Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-03

    ... DEPARTMENT OF AGRICULTURE Forest Service Prince of Wales Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Prince of Wales Resource Advisory Committee... for oral comments must be sent to Prince of Wales RAC c/o District Ranger P.O. Box 500 Craig, AK 99921...

  18. 77 FR 50081 - Prince of Wales Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-20

    ... DEPARTMENT OF AGRICULTURE Forest Service Prince of Wales Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Prince of Wales Resource Advisory Committee... be sent to Prince of Wales RAC c/o District Ranger P.O. Box 500 Craig, AK 99921, or by email to...

  19. 77 FR 19034 - Meeting of the Advisory Committee; Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-29

    ... Joint Board examinations in actuarial mathematics, pension law and methodology referred to in 29 U.S.C... closed meeting of the Advisory Committee on Actuarial Examinations. DATES: The meeting will be held on... INFORMATION: Notice is hereby given that the Advisory Committee on Actuarial Examinations will meet at...

  20. 76 FR 17967 - Meeting of the Advisory Committee; Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-31

    ... Joint Board examinations in actuarial mathematics, pension law and methodology referred to in 29 U.S.C... closed meeting of the Advisory Committee on Actuarial Examinations. DATES: The meeting will be held on... INFORMATION: Notice is hereby given that the Advisory Committee on Actuarial Examinations will meet at Mercer...

  1. A comparative study on radioprotective effect of N-acetylcysteine against 12C6+ ion versus X-rays

    NASA Astrophysics Data System (ADS)

    Liu, Yang; Zhang, Hong; Zhang, Luwei

    Purpose: The aim of this study was to evaluate the different protective efficacy of N-acetylcysteine (NAC, 200 mg/kg dose) against 12C6+ ion (4 Gy) and X-rays (4 Gy) - induced damage in vivo model. Method: Kung-Ming female mice were divided into six groups, each composed of twelve animals: control group, two irradiation groups, and two NAC-treated groups, as well as NAC alone-treated group. An acute study was carried out to determine alterations in the oxidative stress (malondialdehyde level) using with colorimetric method and cell apoptosis measuring by flow cytometry as well as DNA-single strand break analyzing by comet assay at 2h after irradiation in mouse liver. Results: Compared with respective irradiation group, NAC can significantly ameliorate injury induced by two types of ionizing irradiation, which marked by the decrease of malondialdehyde level, and the reduction of apoptosis cells percentage and DNA damage. But the greater efficacy of NAC was prominently observed to inhibit the damage induced by X-rays, suggesting that NAC-mediated protective effect is more advisable to X-rays than 12C6+ ion irradiation. Moreover, NAC treatment alone did not result in any damage as compared to the control group. Conclusion: NAC may merit development as a potential radioprotective agent. Furthermore, NAC might exert its best effort to respond X rays-caused damage.

  2. Study of the 20,22Ne+20,22Ne and 10,12,13,14,15C+12C Fusion Reactions with MUSIC

    NASA Astrophysics Data System (ADS)

    Avila, M. L.; Rehm, K. E.; Almaraz-Calderon, S.; Carnelli, P. F. F.; DiGiovine, B.; Esbensen, H.; Hoffman, C. R.; Jiang, C. L.; Kay, B. P.; Lai, J.; Nusair, O.; Pardo, R. C.; Santiago-Gonzalez, D.; Talwar, R.; Ugalde, C.

    2016-05-01

    A highly efficient MUlti-Sampling Ionization Chamber (MUSIC) detector has been developed for measurements of fusion reactions. A study of fusion cross sections in the 10,12,13,14,15C+12C and 20,22Ne+20,22Ne systems has been performed at ATLAS. Experimental results and comparison with theoretical predictions are presented. Furthermore, results of direct measurements of the 17O(α, n)20Ne, 23Ne(α, p)26Mg and 23Ne(α, n)26Al reactions will be discussed.

  3. 76 FR 6117 - Kenai Peninsula-Anchorage Borough Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-03

    ... DEPARTMENT OF AGRICULTURE Forest Service Kenai Peninsula-Anchorage Borough Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Kenai Peninsula-Anchorage... comments to Kenai Peninsula-Anchorage Borough Resource Advisory Committee, c/o USDA Forest Service, P.O...

  4. 76 FR 75899 - Announcement of Vacancy on the Osage Tribal Education Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-05

    ... Education Committee AGENCY: Bureau of Indian Education, Interior. ACTION: Notice. SUMMARY: The Bureau of Indian Education is announcing that a vacancy has occurred on the Osage Tribal Education Committee. This... nominations to: Osage Tribal Education Committee, c/o Oklahoma Area Education Office, 200 N. W. 4th Street...

  5. Extended reaction scope of thiamine diphosphate dependent cyclohexane-1,2-dione hydrolase: from C-C bond cleavage to C-C bond ligation.

    PubMed

    Loschonsky, Sabrina; Wacker, Tobias; Waltzer, Simon; Giovannini, Pier Paolo; McLeish, Michael J; Andrade, Susana L A; Müller, Michael

    2014-12-22

    ThDP-dependent cyclohexane-1,2-dione hydrolase (CDH) catalyzes the CC bond cleavage of cyclohexane-1,2-dione to 6-oxohexanoate, and the asymmetric benzoin condensation between benzaldehyde and pyruvate. One of the two reactivities of CDH was selectively knocked down by mutation experiments. CDH-H28A is much less able to catalyze the CC bond formation, while the ability for CC bond cleavage is still intact. The double variant CDH-H28A/N484A shows the opposite behavior and catalyzes the addition of pyruvate to cyclohexane-1,2-dione, resulting in the formation of a tertiary alcohol. Several acyloins of tertiary alcohols are formed with 54-94 % enantiomeric excess. In addition to pyruvate, methyl pyruvate and butane-2,3-dione are alternative donor substrates for CC bond formation. Thus, the very rare aldehyde-ketone cross-benzoin reaction has been solved by design of an enzyme variant. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  6. Vitamin C activity of dehydroascorbic acid in humans--association between changes in the blood vitamin C concentration or urinary excretion after oral loading.

    PubMed

    Tsujimura, Masaru; Higasa, Shizu; Nakayama, Kazuhiro; Yanagisawa, Yoshiko; Iwamoto, Sadahiko; Kagawa, Yasuo

    2008-08-01

    We performed oral loading of AsA or DAsA (1 mmol) in subjects who had consumed a diet low in vitamin C (C) (C< or =5 mg/d) for 3 d before loading, and measured urinary and blood vitamin C. Since the crossover method was used, the same experiment was repeated after an interval of about 1 mo in each subject. The results of the experiment including a total of 17 subjects for 2005 and 2006, were as follows. (1) There were marked individual differences in urinary C excretion. (2) The C level in 24-h urine after C loading did not differ between the two orally administered C forms (AsA and DAsA). (3) C excretion between 0 and 3 h after C loading was significantly higher (p<0.05) for the DAsA group, while those between 3 and 6, 6 and 9, 9 and 12, and 12 and 24 h after C loading were significantly higher (p<0.05 or p<0.01) for the AsA group. (4) The blood C concentration and the increase in C 1 h after C loading were significantly higher (p<0.05 and p<0.01, respectively) in the DAsA than in the AsA group. (5) Evaluation of the association between C metabolism and the single nucleotide polymorphisms of glutathione S-transferase P (GSTP) 1-1 showed a lower urinary C excretion and a significantly lower C level in 24-h urine (p<0.05) after AsA loading, and a significantly lower urinary C excretion between 0 and 3 h after DAsA loading (p<0.05) for the GA heterozygotes than for the AA homozygotes. Considering the activity of C as DAsA in humans, based on urinary and blood C levels after a single loading of C, the utilization of DAsA is equivalent to that of AsA, although the metabolic turnover time is different. The involvement of polymorphisms in the xenobiotic metabolizing enzyme, GSTP1-1, in C metabolism, particularly urinary C excretion, was also clarified. This demonstrates the necessity of considering gene polymorphisms in determining individual C requirements. An abstract of this paper was reported by the Vitamin C Research Committee (Ochanomizu University) in 2007.

  7. 78 FR 3500 - Open Meeting of the Taxpayer Advocacy Panel Notices and Correspondence Project Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-16

    ... Project Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments, ideas, and... Correspondence Project Committee will be held Wednesday, February 13, 2013, at 12 p.m. Eastern Time via... Notices and Correspondence Project Committee AGENCY: Internal Revenue Service (IRS), Treasury. ACTION...

  8. 77 FR 74921 - Open Meeting of the Taxpayer Advocacy Panel Notices and Correspondence Project Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-18

    ... Project Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments, ideas, and... Correspondence Project Committee will be held Wednesday, January 9, 2013, at 12 p.m. Eastern Time via... Notices and Correspondence Project Committee AGENCY: Internal Revenue Service (IRS) Treasury. ACTION...

  9. Fractionation of carbon (13C/12C) isotopes in glycine decarboxylase reaction.

    PubMed

    Ivlev, A A; Bykova, N V; Igamberdiev, A U

    1996-05-20

    Fractionation of carbon isotopes (13C/12C) by glycine decarboxylase (GDC) was investigated in mitochondrial preparations isolated from photosynthetic tissues of different plants (Pisum, Medicago, Triticum, Hordeum, Spinacia, Brassica, Wolffia). 20 mM glycine was supplied to mitochondria, and the CO2 formed was absorbed and analyzed for isotopic content. CO2 evolved by mitochondria of Pisum was enriched up to 8% in 12C compared to the carboxylic atom of glycine. CO2 evolved by mitochondria of the other plants investigated was enriched by 5-16% in 13C. Carbon isotope effects were sensitive to reaction conditions (pH and the presence of GDC cofactors). Theoretical treatment of the reaction mechanism enabled us to conclude that the value and even the sign of the carbon isotope effect in glycine decarboxylation depend on the contribution of the enzyme-substrate binding step and of the decarboxylation step itself to the overall reaction rate. Therefore, the fractionation of carbon isotopes in GDC reaction was revealed which provides essential isotopic effects in plants in addition to the well-known effect of carbon isotope fractionation by the central photosynthetic enzyme, ribulose-1,5-biphosphate carboxylase.

  10. Reclassification of the Candida haemulonii complex as Candida haemulonii (C. haemulonii group I), C. duobushaemulonii sp. nov. (C. haemulonii group II), and C. haemulonii var. vulnera var. nov.: three multiresistant human pathogenic yeasts.

    PubMed

    Cendejas-Bueno, E; Kolecka, A; Alastruey-Izquierdo, A; Theelen, B; Groenewald, M; Kostrzewa, M; Cuenca-Estrella, M; Gómez-López, A; Boekhout, T

    2012-11-01

    The Candida haemulonii species complex is currently known as C. haemulonii groups I and II. Here we describe C. haemulonii group II as a new species, Candida duobushaemulonii sp. nov., and C. haemulonii var. vulnera as new a variety of C. haemulonii group I using phenotypic and molecular methods. These taxa and other relatives of C. haemulonii (i.e., Candida auris and Candida pseudohaemulonii) cannot be differentiated by the commercial methods now used for yeast identification. Four isolates (C. haemulonii var. vulnera) differed from the other isolates of C. haemulonii in the sequence of the internal transcribed spacer (ITS) regions of the nuclear rRNA gene operon. The new species and the new variety have a multiresistant antifungal profile, which includes high MICs of amphotericin B (geometric mean MIC, 1.18 mg/liter for C. haemulonii var. vulnera and 2 mg/liter for C. duobushaemulonii sp. nov) and cross-resistance to azole compounds. Identification of these species should be based on molecular methods, such as sequence analysis of ITS regions and matrix-assisted laser desorption ionization-time of flight mass spectrometry.

  11. 75 FR 67347 - Materials Technical Advisory Committee; Notice of Partially Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-02

    ... DEPARTMENT OF COMMERCE Bureau of Industry and Security Materials Technical Advisory Committee; Notice of Partially Closed Meeting The Materials Technical Advisory Committee will meet on November 12... materials and related technology. Agenda Open Session 1. Opening remarks by the Chairman and Introduction. 2...

  12. 75 FR 44227 - Materials Technical Advisory Committee; Notice of Partially Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-28

    ... DEPARTMENT OF COMMERCE Bureau of Industry and Security Materials Technical Advisory Committee; Notice of Partially Closed Meeting The Materials Technical Advisory Committee will meet on August 12... applicable to materials and related technology. Agenda Open Session 1. Opening Remarks and Introduction. 2...

  13. 76 FR 28416 - Prince of Wales Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-17

    ... DEPARTMENT OF AGRICULTURE Forest Service Prince of Wales Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Prince of Wales Resource Advisory Committee... Prince of Wales RAC c/o District Ranger P.O. Box 500 Craig, AK 99921, or by e-mail to [email protected

  14. 77 FR 58095 - Prince of Wales Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-19

    ... DEPARTMENT OF AGRICULTURE Forest Service Prince of Wales Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Prince of Wales Resource Advisory Committee... must be sent to Prince of Wales RAC c/o District Ranger P.O. Box 500 Craig, AK 99921, or by email to...

  15. 78 FR 36575 - Meeting of the Advisory Committee; Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-18

    ... Joint Board examinations in actuarial mathematics and methodology referred to in 29 U.S.C. 1242(a)(1)(B... meeting of the Advisory Committee on Actuarial Examinations (a portion of which will be open to the public...- 2173. SUPPLEMENTARY INFORMATION: Notice is hereby given that the Advisory Committee on Actuarial...

  16. 77 FR 59979 - Meeting of the Advisory Committee; Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-01

    ... actuarial mathematics, pension law and methodology referred to in 29 U.S.C. 1242(a)(1)(B). A determination... closed meeting of the Advisory Committee on Actuarial Examinations. DATES: The meeting will be held on... is hereby given that the Advisory Committee on Actuarial Examinations will meet at Towers Watson, 800...

  17. Similarity-transformed chiral NN + 3N interactions for the ab initio description of 12C and 16O.

    PubMed

    Roth, Robert; Langhammer, Joachim; Calci, Angelo; Binder, Sven; Navrátil, Petr

    2011-08-12

    We present first ab initio no-core shell model (NCSM) calculations using similarity renormalization group (SRG) transformed chiral two-nucleon (NN) plus three-nucleon (3N) interactions for nuclei throughout the p-shell, particularly (12)C and (16)O. By introducing an adaptive importance truncation for the NCSM model space and an efficient JT-coupling scheme for the 3N matrix elements, we are able to surpass previous NCSM studies including 3N interactions. We present ground and excited states in (12)C and (16)O for model spaces up to N(max) = 12 including full 3N interactions. We analyze the contributions of induced and initial 3N interactions and probe induced 4N terms through the sensitivity of the energies on the SRG flow parameter. Unlike for light p-shell nuclei, SRG-induced 4N contributions originating from the long-range two-pion terms of the chiral 3N interaction are sizable in (12)C and (16)O.

  18. A cross-sectional survey to investigate community understanding of medical research ethics committees.

    PubMed

    Fritschi, Lin; Kelsall, Helen L; Loff, Bebe; Slegers, Claudia; Zion, Deborah; Glass, Deborah C

    2015-07-01

    Study explanatory forms often state that an ethics committee has approved a research project. To determine whether the lay community understand the roles of ethics committees in research, we took a cross-sectional national sample from three sampling frames: the general population (n=1532); cohort study participants (n=397); and case-control study participants (n=151). About half (51.3%) of the participants had heard of ethics committees. Those who had were more likely to be those who had participated in previous surveys, older participants, those born in Australia and those with higher education. Almost all participants agreed that the roles of an ethics committee were to protect participants' privacy and ensure no harm came to study participants and most agreed that the committee's role was to ensure that the research was capable of providing answers. Case-control and cohort participants were more likely than the general population to consider that the role of an ethics committee was to design the research and obtain research funding. Overall, we found that about half of the population are aware of ethics committees and that most could correctly identify that ethics committees are there to protect the welfare and rights of research participants, although a substantial minority had some incorrect beliefs about the committees' roles. Increased education, particularly for migrants and older people, might improve understanding of the role of ethics committees in research. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  19. PREFACE: 12th Conference on Recent Developments in Gravity (NEB XII)

    NASA Astrophysics Data System (ADS)

    Christodoulakis, Theodosios; Vagenas, Elias C.

    2007-06-01

    Continuing the 24 year old tradition, one of the Greek relativistic groups, this time the Relativity Group of the Physics Department of the University of Athens, organized the 12th Conference of the series "Recent Developments in Gravity" (NEB XII). This time NEB took place at Nafplio, Greece, from Thursday 29 June to Sunday 2 July, 2006. The Conference was attended by more than 100 participants, more than 50% of whom were relativists from abroad (both Greek and other nationalities). This signifies a tendency of the last few Conferences to open up the Greek Relativity Conference to the international scientific community. Actually, many notable members of the relativistic community all over the globe showed particular interest in coming to Nafplio, and spend four relaxed days in a nice sunny and historical place, presenting the results of their more recent work and discussing it with colleagues and students from Greece. The NEB XII Conference covered various aspects of gravitational physics: Relativistic Astrophysics, Mathematical Relativity, Quantum Gravity, and Cosmology. Although the program was rather heavy and for the first time we had parallel sessions running in the afternoons, the wonderful weather (apart from the last afternoon when it rained heavily) and the beauty of Nafplio helped the organizers offer the participants a warm, pleasant, and creative time. According to most attendees, their impression was more than good, not only with respect to the hospitable environment, but with respect to the high level of talks as well. We hope the next Conference, which will be organized by the Relativity Group of the Aristotle University of Thessaloniki in the summer of 2008, will raise the standards of the Conference even higher, thus further establishing our Conference as a notable Conference in the Relativistic community all over the world. Finally, we would like to thank the Gravitational Physics Section of the European Physical Society (GPS/EPS), ILIAS

  20. 75 FR 39910 - Prince William Sound Resource Advisory Committee; Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-13

    ... DEPARTMENT OF AGRICULTURE Forest Service Prince William Sound Resource Advisory Committee; Meeting AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Prince William Sound Resource..., Anchorage, Alaska 99503. Send written comments to Prince William Sound Resource Advisory Committee, c/o USDA...

  1. Enhancement of palmarumycin C12 and C13 production in liquid culture of the endophytic fungus Berkleasmium sp. Dzf12 by oligosaccharides from its host plant Dioscorea zingiberensis.

    PubMed

    Li, Yan; Shan, Tijiang; Mou, Yan; Li, Peiqin; Zhao, Jianglin; Zhao, Wensheng; Peng, Youliang; Zhou, Ligang; Ding, Chunbang

    2012-03-26

    Three crude oligosaccharides were respectively prepared by acid hydrolysis of three polysaccharides, which were water-extracted polysaccharide (WEP), sodium hydroxide-extracted polysaccharide (SEP) and acid-extracted polysaccharide (AEP) from the rhizomes of Dioscorea zingiberensis. Among the three oligosaccharides, the crude oligosaccharide prepared by acid hydrolysis of WEP was found to be the most efficient elicitor to enhance the production of palmarumycins C(12) and C(13) in liquid culture of endophytic fungus Berkleasmium sp. Dzf12. When OW was applied to the medium at 300 mg/L on day 3 of culture, the maximal yields of palmarumycin C(12) (87.96 mg/L) and palmarumycin C(13) (422.28 mg/L) were achieved on day 15 of culture, which were 9.83 and 3.24-fold in comparison with those (8.95 and 130.43 mg/L) of control, respectively. The results indicate that addition of the oligosaccharides from the host plant D. zingiberensis should be an effective strategy for enhancing production of palmarumycins C(12) and C(13) in liquid culture of endophytic fungus Berkleasmium sp. Dzf12.

  2. Panel Discussion : Report of the APS Ad-Hoc Committee on LGBT Issues

    NASA Astrophysics Data System (ADS)

    Atherton, Tim; Barthelemy, Ramon; Garmon, Savannah; Reeves, Kyle; APS Ad-Hoc Committee on LGBT Issues Team

    Following the presentation of the findings and recommendations of the APS Ad-Hoc Committee on LGBT Issues (C-LGBT) by Committee Chair Michael Falk, a panel discussion will be held featuring several members of the committee. The discussion will focus on how APS can best ensure the recommendations of the committee are carried out in a timely fashion and other ideas on future APS efforts toward LGBT inclusion in physics. Discussion topics will also include the research and other input that shaped the committee's findings and recommendations.

  3. 78 FR 61870 - Advisory Committee for Computer and Information Science and Engineering; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-04

    ... NATIONAL SCIENCE FOUNDATION Advisory Committee for Computer and Information Science and Engineering; Notice of Meeting In accordance with Federal Advisory Committee Act (Pub. L. 92-463, as amended... Committee for Computer and Information Science and Engineering (1115). Date/Time: Oct 31, 2013: 12:30 p.m...

  4. 75 FR 17417 - Joint Meeting of the Arthritis Advisory Committee and the Drug Safety and Risk Management...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-06

    ...] Joint Meeting of the Arthritis Advisory Committee and the Drug Safety and Risk Management Advisory... Arthritis Advisory Committee and the Drug Safety and Risk Management Advisory Committee. This meeting was... Drug Safety and Risk Management Advisory Committee would be held on May 12, 2010. On page 10490, in the...

  5. 76 FR 22395 - Federal Advisory Committee Act; Open Internet Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-21

    ... FEDERAL COMMUNICATIONS COMMISSION Federal Advisory Committee Act; Open Internet Advisory Committee... Advisory Committee, known as the ``Open Internet Advisory Committee'' (hereinafter ``the Committee''), is... effects of the FCC's Open Internet rules (available at http://www.fcc.gov/Daily_Releases/Daily_Business...

  6. 77 FR 34408 - Meeting of the Advisory Committee; Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-11

    ... examinations in actuarial mathematics and methodology referred to in 29 U.S.C. 1242(a)(1)(B) and to review the... meeting of the Advisory Committee on Actuarial Examinations (a portion of which will be open to the public.... SUPPLEMENTARY INFORMATION: Notice is hereby given that the Advisory Committee on Actuarial Examinations will...

  7. 77 FR 51970 - Renewal of Missile Defense Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-28

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  8. 76 FR 7816 - Civil Nuclear Trade Advisory Committee Public Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-11

    ... U.S. Japan Global Nuclear Energy Cooperation Working Group, U.S. industry program at the... submitted to the Civil Nuclear Trade Advisory Committee, Office of Energy & Environmental Industries, Room... DEPARTMENT OF COMMERCE International Trade Administration Civil Nuclear Trade Advisory Committee...

  9. 76 FR 21331 - Materials Technical Advisory Committee; Notice of Partially Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-15

    ... DEPARTMENT OF COMMERCE Bureau of Industry and Security Materials Technical Advisory Committee; Notice of Partially Closed Meeting The Materials Technical Advisory Committee will meet on May 12, 2011... materials and related technology. Agenda Open Session 1. Opening Remarks by the Chairman and Introduction. 2...

  10. Downregulation of lipin-1 induces insulin resistance by increasing intracellular ceramide accumulation in C2C12 myotubes

    PubMed Central

    Huang, Shujuan; Huang, Suling; Wang, Xi; Zhang, Qingli; Liu, Jia; Leng, Ying

    2017-01-01

    Dysregulation of lipid metabolism in skeletal muscle is involved in the development of insulin resistance. Mutations in lipin-1, a key lipid metabolism regulator leads to significant systemic insulin resistance in fld mice. However, the function of lipin-1 on lipid metabolism and insulin sensitivity in skeletal muscle is still unclear. Herein we demonstrated that downregulation of lipin-1 in C2C12 myotubes by siRNA transfection suppressed insulin action, characterized by reduced insulin stimulated Akt phosphorylation and glucose uptake. Correspondingly, decreased lipin-1 expression was observed in palmitate-induced insulin resistance in C2C12 myotubes, suggested that lipin-1 might play a role in the etiology of insulin resistance in skeletal muscle. The insulin resistance induced by lipin-1 downregulation was related to the disturbance of lipid homeostasis. Lipin-1 silencing reduced intracellular DAG and TAG levels, but elevated ceramide accumulation in C2C12 myotubes. Moreover, the impaired insulin stimulated Akt phosphorylation and glucose uptake caused by lipin-1 silencing could be blocked by the pretreatment with SPT inhibitor myriocin, ceramide synthase inhibitor FB1, or PP2A inhibitor okadaic acid, suggested that the increased ceramide accumulation might be responsible for the development of insulin resistance induced by lipin-1 silencing in C2C12 myotubes. Meanwhile, decreased lipin-1 expression also impaired mitochondrial function in C2C12 myotubes. Therefore, our study suggests that lipin-1 plays an important role in lipid metabolism and downregulation of lipin-1 induces insulin resistance by increasing intracellular ceramide accumulation in C2C12 myotubes. These results offer a molecular insight into the role of lipin-1 in the development of insulin resistance in skeletal muscle. PMID:28123341

  11. Downregulation of lipin-1 induces insulin resistance by increasing intracellular ceramide accumulation in C2C12 myotubes.

    PubMed

    Huang, Shujuan; Huang, Suling; Wang, Xi; Zhang, Qingli; Liu, Jia; Leng, Ying

    2017-01-01

    Dysregulation of lipid metabolism in skeletal muscle is involved in the development of insulin resistance. Mutations in lipin-1, a key lipid metabolism regulator leads to significant systemic insulin resistance in fld mice. However, the function of lipin-1 on lipid metabolism and insulin sensitivity in skeletal muscle is still unclear. Herein we demonstrated that downregulation of lipin-1 in C2C12 myotubes by siRNA transfection suppressed insulin action, characterized by reduced insulin stimulated Akt phosphorylation and glucose uptake. Correspondingly, decreased lipin-1 expression was observed in palmitate-induced insulin resistance in C2C12 myotubes, suggested that lipin-1 might play a role in the etiology of insulin resistance in skeletal muscle. The insulin resistance induced by lipin-1 downregulation was related to the disturbance of lipid homeostasis. Lipin-1 silencing reduced intracellular DAG and TAG levels, but elevated ceramide accumulation in C2C12 myotubes. Moreover, the impaired insulin stimulated Akt phosphorylation and glucose uptake caused by lipin-1 silencing could be blocked by the pretreatment with SPT inhibitor myriocin, ceramide synthase inhibitor FB1, or PP2A inhibitor okadaic acid, suggested that the increased ceramide accumulation might be responsible for the development of insulin resistance induced by lipin-1 silencing in C2C12 myotubes. Meanwhile, decreased lipin-1 expression also impaired mitochondrial function in C2C12 myotubes. Therefore, our study suggests that lipin-1 plays an important role in lipid metabolism and downregulation of lipin-1 induces insulin resistance by increasing intracellular ceramide accumulation in C2C12 myotubes. These results offer a molecular insight into the role of lipin-1 in the development of insulin resistance in skeletal muscle.

  12. Introduction and Committees

    NASA Astrophysics Data System (ADS)

    Angelova, Maia; Zakrzewski, Wojciech; Hussin, Véronique; Piette, Bernard

    2011-03-01

    This volume contains contributions to the XXVIIIth International Colloquium on Group-Theoretical Methods in Physics, the GROUP 28 conference, which took place in Newcastle upon Tyne from 26-30 July 2010. All plenary and contributed papers have undergone an independent review; as a result of this review and the decisions of the Editorial Board most but not all of the contributions were accepted. The volume is organised as follows: it starts with notes in memory of Marcos Moshinsky, followed by contributions related to the Wigner Medal and Hermann Weyl prize. Then the invited talks at the plenary sessions and the public lecture are published followed by contributions in the parallel and poster sessions in alphabetical order. The Editors:Maia Angelova, Wojciech Zakrzewski, Véronique Hussin and Bernard Piette International Advisory Committee Michael BaakeUniversity of Bielefeld, Germany Gerald DunneUniversity of Connecticut, USA J F (Frank) GomesUNESP, Sao Paolo, Brazil Peter HanggiUniversity of Augsburg, Germany Jeffrey C LagariasUniversity of Michigan, USA Michael MackeyMcGill University, Canada Nicholas MantonCambridge University, UK Alexei MorozovITEP, Moscow, Russia Valery RubakovINR, Moscow, Russia Barry SandersUniversity of Calgary, Canada Allan SolomonOpen University, Milton Keynes, UK Christoph SchweigertUniversity of Hamburg, Germany Standing Committee Twareque AliConcordia University, Canada Luis BoyaSalamanca University, Spain Enrico CeleghiniFirenze University, Italy Vladimir DobrevBulgarian Academy of Sciences, Bulgaria Heinz-Dietrich DoebnerHonorary Member, Clausthal University, Germany Jean-Pierre GazeauChairman, Paris Diderot University, France Mo-Lin GeNankai University. China Gerald GoldinRutgers University, USA Francesco IachelloYale University, USA Joris Van der JeugtGhent University, Belgium Richard KernerPierre et Marie Curie University, France Piotr KielanowskiCINVESTAV, Mexico Alan KosteleckyIndiana University, USA Mariano del Olmo

  13. A comparative theoretical study on the structural, electronic and nonlinear optical features of B12N12 and Al12N12 nanoclusters with the groups III, IV and V dopants

    NASA Astrophysics Data System (ADS)

    Shakerzadeh, Ehsan; Barazesh, Neda; Talebi, Sima Zargar

    2014-12-01

    The structural, electronic and nonlinear optical properties of the two important fullerene-like cages of B12N12 and Al12N12 nanostructures with the groups III, IV and V dopants are investigated through density functional theory (DFT) calculations. It has been found that doping process induces local deformation at bond lengths near the doping site. Natural bond orbital (NBO) analyses are also performed for scrutinizing the structural properties of the considered nanoclusters. The results indicate that the groups III, IV and V dopants remarkably narrow the energy gap of the B12N12 nanocluster. On the other hand, although the energy gap of Al12N12 nanocluster is insensitive to groups III and V dopants; the carbon, silicon and germanium dopants extremely reduce the energy gap of this cluster. It seems that the electronic character of the B12N12 and Al12N12 nanocluster is sensitive to the dopants and it could be adjusted by particular impurity. Moreover the considered dopants induce hyperpolarizability in both of the considered nanoclusters. Interestingly, the replacing aluminum atom by carbon one in Al12N12 nanocluster (CAl11N12) leads to an extremely large hyperpolarizability value of 4358.77 a.u., which is the largest one among the considered doped clusters. It shows that the doping process plays an important role in enhancing the first hyperpolarizability of the B12N12 and Al12N12 nanoclusters.

  14. 75 FR 37813 - Secretary's Advisory Committee on Human Research Protections

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-30

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Secretary's Advisory Committee on Human Research Protections AGENCY: Department of Health and Human Services, Office of the Secretary, Office of Public Health..., U.S.C. Appendix 2, notice is hereby given that the Secretary's Advisory Committee on Human Research...

  15. Vitamin C-linker-conjugated tripeptide AHK stimulates BMP-2-induced osteogenic differentiation of mouse myoblast C2C12 cells.

    PubMed

    Jung, Jung-Il; Park, Kyeong-Yong; Lee, Yura; Park, Mira; Kim, Jiyeon

    Vitamin C-linker-conjugated Ala-His-Lys tripeptide (Vit C-AHK) is a derivative of Vitamin C-conjugated tripeptides, which were originally developed as a component of a product for collagen synthesis enhancement or human dermal fibroblast growth. Here, we investigated the effect of Vit C-AHK on bone morphogenetic protein (BMP)-2-induced osteoblast differentiation in a cell culture model. Vit C-AHK enhanced proliferation of C2C12 cells and induction of BMP-2-induced alkaline phosphatase, a typical marker of osteoblast differentiation. Vit C-AHK also stimulated the phosphorylation and translocation of Smad1/5/8 to the nucleus and phosphorylation of mitogen-activated protein kinases (MAPKs) including ERK1/2 and p38. In addition, Vit C-AHK enhanced the BMP-2-induced mRNA expression of osteoblast differentiation-related genes such as ALP, BMP-2, Osteocalcin, and Runx2. Our results suggest that Vit C-AHK exerts an enhancing effect on osteoblast proliferation and differentiation through activation of Smad1/5/8 and MAPK ERK1/2 and p38 signaling and without significant cytotoxicity. These results provide important data for the development of peptide-based bone-regenerative agents and treatment of bone-related disorders. Copyright © 2018 International Society of Differentiation. Published by Elsevier B.V. All rights reserved.

  16. Decay modes of the Hoyle state in 12C

    NASA Astrophysics Data System (ADS)

    Zheng, H.; Bonasera, A.; Huang, M.; Zhang, S.

    2018-04-01

    Recent experimental results give an upper limit less than 0.043% (95% C.L.) to the direct decay of the Hoyle state into 3α respect to the sequential decay into 8Be + α. We performed one and two-dimensional tunneling calculations to estimate such a ratio and found it to be more than one order of magnitude smaller than experiment depending on the range of the nuclear force. This is within high statistics experimental capabilities. Our results can also be tested by measuring the decay modes of high excitation energy states of 12C where the ratio of direct to sequential decay might reach 10% at E*(12C) = 10.3 MeV. The link between a Bose Einstein Condensate (BEC) and the direct decay of the Hoyle state is also addressed. We discuss a hypothetical 'Efimov state' at E*(12C) = 7.458 MeV, which would mainly sequentially decay with 3α of equal energies: a counterintuitive result of tunneling. Such a state, if it would exist, is at least 8 orders of magnitude less probable than the Hoyle's, thus below the sensitivity of recent and past experiments.

  17. Members of House Committee on Science and Astronautics Visited MSFC

    NASA Technical Reports Server (NTRS)

    1962-01-01

    The members of the House Committee on Science and Astronautics visited the Marshall Space Flight Center (MSFC) on March 9, 1962 to gather first-hand information of the nation's space exploration program. The congressional group was composed of members of the Subcommittee on Marned Space Flight. Headed by Representative Olin E. Teague of Texas, other members were James G. Fulton, Pennsylvania; Ken Heckler, West Virginia; R. Walter Riehlman, New York; Richard L. Roudebush, Indiana; John W. Davis, Georgia; James C. Corman, California; Joseph Waggoner, Louisiana; J. Edgar Chenoweth, Colorado; and William G. Bray, Indiana.

  18. Members of House Committee on Science and Astronautics Visited MSFC

    NASA Technical Reports Server (NTRS)

    1962-01-01

    The members of the House Committee on Science and Astronautics visited the Marshall Space Flight Center (MSFC) on March 9, 1962 to gather first-hand information of the nation's space exploration program. The congressional group was composed of members of the Subcommittee on Marned Space Flight. Headed by Representative Olin E. Teague of Texas, other members were James G. Fulton, Pennsylvania; Ken Heckler, West Virginia; R. Walter Riehlman, New York; Richard L. Roudebush,, Indiana; John W. Davis, Georgia; James C. Corman, California; Joseph Waggoner, Louisiana; J. Edgar Chenoweth, Colorado; and William G. Bray, Indiana.

  19. 77 FR 35063 - Whistleblower Protection Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-12

    ... Railroad Safety Act, 49 U.S.C. 20109; the National Transit Systems Security Act, 6 U.S.C. 1142; the... DEPARTMENT OF LABOR Occupational Safety and Health Administration [Docket Number OSHA-2012-0020] Whistleblower Protection Advisory Committee AGENCY: Occupational Safety and Health Administration (OSHA), DOL...

  20. Thermochemical Properties Enthalpy, Entropy, and Heat Capacity of C1-C4 Fluorinated Hydrocarbons: Fluorocarbon Group Additivity.

    PubMed

    Wang, Heng; Castillo, Álvaro; Bozzelli, Joseph W

    2015-07-23

    Enthalpies of formation for 14 C2–C4 fluorinated hydrocarbons were calculated with nine popular ab initio and density functional theory methods: B3LYP, CBS-QB3, CBS-APNO, M06, M06-2X, ωB97X, G4, G4(MP2)-6X, and W1U via several series of isodesmic reactions. The recommended ideal gas phase ΔHf298° (kcal mol(–1)) values calculated in this study are the following: −65.4 for CH3CH2F; −70.2 for CH3CH2CH2F; −75.3 for CH3CHFCH3; −75.2 for CH3CH2CH2CH2F; −80.3 for CH3CHFCH2CH3; −108.1 for CH2F2; −120.9 for CH3CHF2; −125.8 for CH3CH2CHF2; −133.3 for CH3CF2CH3; −166.7 for CHF3; −180.5 for CH3CF3; −185.5 for CH3CH2CF3; −223.2 for CF4; and −85.8 for (CH3)3CF. Entropies (S298° in cal mol(–1) K(–1)) were estimated using B3LYP/6-31+G(d,p) computed frequencies and geometries. Rotational barriers were determined and hindered internal rotational contributions for S298°, and Cp(T) were calculated using the rigid rotor harmonic oscillator approximation, with direct integration over energy levels of the intramolecular rotation potential energy curve. Thermochemical properties for the fluorinated carbon groups C/C/F/H2, C/C2/F/H, C/C/F2/H, C/C2/F2, and C/C/F3 were derived from the above target fluorocarbons. Previously published enthalpies and groups for 1,2-difluoroethane, 1,1,2-trifluoroethane, 1,1,2,2-tetrafluoroethane, 1,1,1,2-tetrafluoroethane, 1,1,1,2,2-pentafluoroethane, 2-fluoro-2-methylpropane that were previously determined via work reaction schemes are revised using updated reference species values. Standard deviations are compared for the calculation methods.

  1. 31 CFR 800.203 - Committee; Chairperson of the Committee; Staff Chairperson.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Committee; Staff Chairperson. 800.203 Section 800.203 Money and Finance: Treasury Regulations Relating to...; Chairperson of the Committee; Staff Chairperson. The term Committee means the Committee on Foreign Investment in the United States. The Chairperson of the Committee is the Secretary of the Treasury. The Staff...

  2. 31 CFR 800.203 - Committee; Chairperson of the Committee; Staff Chairperson.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Committee; Staff Chairperson. 800.203 Section 800.203 Money and Finance: Treasury Regulations Relating to...; Chairperson of the Committee; Staff Chairperson. The term Committee means the Committee on Foreign Investment in the United States. The Chairperson of the Committee is the Secretary of the Treasury. The Staff...

  3. 31 CFR 800.203 - Committee; Chairperson of the Committee; Staff Chairperson.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Committee; Staff Chairperson. 800.203 Section 800.203 Money and Finance: Treasury Regulations Relating to...; Chairperson of the Committee; Staff Chairperson. The term Committee means the Committee on Foreign Investment in the United States. The Chairperson of the Committee is the Secretary of the Treasury. The Staff...

  4. AGU Committees

    NASA Astrophysics Data System (ADS)

    Administrative Committees are responsible for those functions required for the overall performance or well-being of AGU as an organization. These committees are Audit and Legal Affairs, Budget and Finance*, Development, Nominations*, Planning, Statutes and Bylaws*, Tellers.Operating Committees are responsible for the policy direction and operational oversight of AGU's primary programs. The Operating Committees are Education and Human Resources, Fellows*, Information Technology, International Participation*, Meetings, Public Affairs, Public Information, Publications*.

  5. 78 FR 18624 - U.S. Extractive Industries Transparency Initiative Multi-Stakeholder Group (USEITI MSG) Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-27

    ... DEPARTMENT OF THE INTERIOR Office of the Secretary [Docket No. ONRR-2012-0003] U.S. Extractive Industries Transparency Initiative Multi- Stakeholder Group (USEITI MSG) Advisory Committee AGENCY: Policy..., teleconference and the May 1-2, 2013, meeting of the United States Extractive Industries Transparency Initiative...

  6. Nqrs Data for C24H76BLiN12O4P4 (Subst. No. 1593)

    NASA Astrophysics Data System (ADS)

    Chihara, H.; Nakamura, N.

    This document is part of Subvolume B 'Substances Containing C10H16 … Zn' of Volume 48 'Nuclear Quadrupole Resonance Spectroscopy Data' of Landolt-Börnstein - Group III 'Condensed Matter'. It contains an extract of Section '3.2 Data tables' of the Chapter '3 Nuclear quadrupole resonance data' providing the NQRS data for C24H76BLiN12O4P4 (Subst. No. 1593)

  7. 75 FR 81645 - Meeting of the Judicial Conference Advisory Committee on Rules of Evidence

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-28

    ..., Philadelphia, PA 19104. FOR FURTHER INFORMATION CONTACT: Peter G. McCabe, Secretary, Rules Committee Support.... Dated: December 21, 2010. Peter G. McCabe, Rules Committee Support Office. [FR Doc. 2010-32433 Filed 12...

  8. 11 CFR 100.11 - State (2 U.S.C. 431(12)).

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 11 Federal Elections 1 2010-01-01 2010-01-01 false State (2 U.S.C. 431(12)). 100.11 Section 100.11 Federal Elections FEDERAL ELECTION COMMISSION GENERAL SCOPE AND DEFINITIONS (2 U.S.C. 431) General Definitions § 100.11 State (2 U.S.C. 431(12)). State means each State of the United States, the District of...

  9. 76 FR 2916 - Houston/Galveston Navigation Safety Advisory Committee; Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-18

    ... DEPARTMENT OF HOMELAND SECURITY Coast Guard [USCG-2010-1116] Houston/Galveston Navigation Safety.../Galveston Navigation Safety Advisory Committee (``HOGANSAC'' or ``the Committee'') and its working groups will meet in Texas City, Texas and Houston, Texas to discuss waterway improvements, aids to navigation...

  10. Human Space Flight Plans Committee

    NASA Image and Video Library

    2009-08-11

    Members of the Human Space Flight Review Committee from left, Jeffrey Greason, Dr. Christopher Chyba, Dr. Leroy Chiao, Dr. Sally Ride, Norman Augustine (chair), Philip McAllister, Dr. Edward Crawley, Dr. Wanda Austin, and Bhodan Bejmuk review their notes prior to the start of a public meeting, Wednesday, Aug. 12, 2009, in Washington. Photo Credit: (NASA/Paul E. Alers)

  11. 76 FR 32203 - FDIC Systemic Resolution Advisory Committee; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-03

    ... accordance with the Federal Advisory Committee Act, 5 U.S.C. App. 2, notice is hereby given of a meeting of... Washington, DC. The SR Advisory Committee will provide advice and recommendations on a broad range of issues...

  12. 77 FR 70162 - FDIC Systemic Resolution Advisory Committee; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-23

    ... accordance with the Federal Advisory Committee Act, 5 U.S.C. App. 2, notice is hereby given of a meeting of... Washington, DC. The SR Advisory Committee will provide advice and recommendations on a broad range of issues...

  13. Fusion hindrance for the positive Q -value system 12C+30Si

    NASA Astrophysics Data System (ADS)

    Montagnoli, G.; Stefanini, A. M.; Jiang, C. L.; Hagino, K.; Galtarossa, F.; Colucci, G.; Bottoni, S.; Broggini, C.; Caciolli, A.; Čolović, P.; Corradi, L.; Courtin, S.; Depalo, R.; Fioretto, E.; Fruet, G.; Gal, A.; Goasduff, A.; Heine, M.; Hu, S. P.; Kaur, M.; Mijatović, T.; Mazzocco, M.; Montanari, D.; Scarlassara, F.; Strano, E.; Szilner, S.; Zhang, G. X.

    2018-02-01

    Background: The fusion reaction 12C+30Si is a link between heavier cases studied in recent years, and the light heavy-ion systems, e.g., 12C+12C , 16O+16O that have a prominent role in the dynamics of stellar evolution. 12C+30Si fusion itself is not a relevant process for astrophysics, but it is important to establish its behavior below the barrier, where couplings to low-lying collective modes and the hindrance phenomenon may determine the cross sections. The excitation function is presently completely unknown below the barrier for the 12C+30Si reaction, thus no reliable extrapolation into the astrophysical regime for the C+C and O+O cases can be performed. Purpose: Our aim was to carry out a complete measurement of the fusion excitation function of 12C+30Si from well below to above the Coulomb barrier, so as to clear up the consequence of couplings to low-lying states of 30Si, and whether the hindrance effect appears in this relatively light system which has a positive Q value for fusion. This would have consequences for the extrapolated behavior to even lighter systems. Methods: The inverse kinematics was used by sending 30Si beams delivered from the XTU Tandem accelerator of INFN-Laboratori Nazionali di Legnaro onto thin 12C (50 μ g /cm2 ) targets enriched to 99.9 % in mass 12. The fusion evaporation residues (ER) were detected at very forward angles, following beam separation by means of an electrostatic deflector. Angular distributions of ER were measured at Ebeam=45 , 59, and 80 MeV, and they were angle integrated to derive total fusion cross sections. Results: The fusion excitation function of 12C+30Si was measured with high statistical accuracy, covering more than five orders of magnitude down to a lowest cross section ≃3 μ b . The logarithmic slope and the S factor have been extracted and we have convincing phenomenological evidence of the hindrance effect. These results have been compared with the calculations performed within the model that

  14. 76 FR 72904 - National Construction Safety Team Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-28

    ... Team Advisory Committee Meeting AGENCY: National Institute of Standards and Technology, Department of Commerce. ACTION: Notice of open meeting. SUMMARY: The National Construction Safety Team (NCST) Advisory... Team Act (15 U.S.C. 7301 et seq.). The NCST Advisory Committee is comprised of ten members, appointed...

  15. 77 FR 74828 - National Construction Safety Team Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-18

    ... Team Advisory Committee Meeting AGENCY: National Institute of Standards and Technology, Department of Commerce. ACTION: Notice of open meeting. SUMMARY: The National Construction Safety Team (NCST) Advisory... Construction Safety Team Act (15 U.S.C. 7301 et seq.). The NCST Advisory Committee is comprised of ten members...

  16. 42 CFR 456.206 - Organization and composition of UR committee; disqualification from UR committee membership.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...; disqualification from UR committee membership. 456.206 Section 456.206 Public Health CENTERS FOR MEDICARE... UTILIZATION CONTROL Utilization Control: Mental Hospitals Ur Plan: Administrative Requirements § 456.206... the diagnosis and treatment of mental diseases, and assisted by other professional personnel. (c) The...

  17. 42 CFR 456.206 - Organization and composition of UR committee; disqualification from UR committee membership.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...; disqualification from UR committee membership. 456.206 Section 456.206 Public Health CENTERS FOR MEDICARE... UTILIZATION CONTROL Utilization Control: Mental Hospitals Ur Plan: Administrative Requirements § 456.206... the diagnosis and treatment of mental diseases, and assisted by other professional personnel. (c) The...

  18. 42 CFR 456.206 - Organization and composition of UR committee; disqualification from UR committee membership.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...; disqualification from UR committee membership. 456.206 Section 456.206 Public Health CENTERS FOR MEDICARE... UTILIZATION CONTROL Utilization Control: Mental Hospitals Ur Plan: Administrative Requirements § 456.206... the diagnosis and treatment of mental diseases, and assisted by other professional personnel. (c) The...

  19. 42 CFR 456.206 - Organization and composition of UR committee; disqualification from UR committee membership.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...; disqualification from UR committee membership. 456.206 Section 456.206 Public Health CENTERS FOR MEDICARE... UTILIZATION CONTROL Utilization Control: Mental Hospitals Ur Plan: Administrative Requirements § 456.206... the diagnosis and treatment of mental diseases, and assisted by other professional personnel. (c) The...

  20. 47 CFR 80.514 - Marine VHF frequency coordinating committee(s).

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 5 2014-10-01 2014-10-01 false Marine VHF frequency coordinating committee(s... SPECIAL RADIO SERVICES STATIONS IN THE MARITIME SERVICES Private Coast Stations and Marine Utility Stations § 80.514 Marine VHF frequency coordinating committee(s). This section contains the names of...

  1. 77 FR 66856 - Merchant Marine Personnel Advisory Committee: Intercessional Meeting AGENCY: Coast Guard, DHS

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-07

    ... Committee Working Group Meeting. SUMMARY: A working group of the Merchant Marine Personnel Advisory Committee (MERPAC) will meet to work on Task Statement 77 concerning the development of new performance...-Technical Ratings. This meeting will be open to the public. DATES: A MERPAC working group will meet on...

  2. 40 CFR 721.10283 - Poly[oxy(methyl-1,2-ethanediyl)], .alpha.-sulfo-.omega.-hydroxy-, C12-13-branched and linear...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...)], .alpha.-sulfo-.omega.-hydroxy-, C12-13-branched and linear alkyl ethers, sodium salts. 721.10283 Section... Substances § 721.10283 Poly[oxy(methyl-1,2-ethanediyl)], .alpha.-sulfo-.omega.-hydroxy-, C12-13-branched and.... (1) The chemical substance identified as poly[oxy(methyl-1,2-ethanediyl)], .alpha.-sulfo-.omega...

  3. 40 CFR 721.10283 - Poly[oxy(methyl-1,2-ethanediyl)], .alpha.-sulfo-.omega.-hydroxy-, C12-13-branched and linear...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...)], .alpha.-sulfo-.omega.-hydroxy-, C12-13-branched and linear alkyl ethers, sodium salts. 721.10283 Section... Substances § 721.10283 Poly[oxy(methyl-1,2-ethanediyl)], .alpha.-sulfo-.omega.-hydroxy-, C12-13-branched and.... (1) The chemical substance identified as poly[oxy(methyl-1,2-ethanediyl)], .alpha.-sulfo-.omega...

  4. 40 CFR 721.10283 - Poly[oxy(methyl-1,2-ethanediyl)], .alpha.-sulfo-.omega.-hydroxy-, C12-13-branched and linear...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...)], .alpha.-sulfo-.omega.-hydroxy-, C12-13-branched and linear alkyl ethers, sodium salts. 721.10283 Section... Substances § 721.10283 Poly[oxy(methyl-1,2-ethanediyl)], .alpha.-sulfo-.omega.-hydroxy-, C12-13-branched and.... (1) The chemical substance identified as poly[oxy(methyl-1,2-ethanediyl)], .alpha.-sulfo-.omega...

  5. Group Medical Visits (GMVs) in primary care: an RCT of group-based versus individual appointments to reduce HbA1c in older people

    PubMed Central

    Khan, Karim M; Windt, Adriaan; Davis, Jennifer C; Dawes, Martin; Liu-Ambrose, Teresa; Madden, Ken; Marra, Carlo A; Housden, Laura; Hoppmann, Christiane; Adams, David J

    2015-01-01

    Introduction Type 2 diabetes mellitus (T2DM) affects more than 1.1 million Canadians aged ≥65 years. Group Medical Visits are an emerging health service delivery method. Recent systematic reviews show that they can significantly reduce glycated haemoglobin (HbA1c) levels, but Group Visits have not been evaluated within primary care. We intend to determine the clinical effectiveness, quality of life and economic implications of Group Medical Visits within a primary care setting for older people with T2DM. Methods and analysis A 2-year proof-of-concept, single-blinded (measurement team) randomised control trial to test the efficacy of Group Medical Visits in an urban Canadian primary care setting. Participants ≥65 years old with T2DM (N=128) will be equally randomised to either eight groups of eight patients each (Group Medical Visits; Intervention) or to Individual visits (Standard Care; Controls). Those administering cointerventions are not blinded to group assignment. Our sample size is based on estimates of variance (±1.4% for HbA1c) and effect size (0.9/1.4=0.6) from the literature and from our own preliminary data. Forty participants per group will provide a β likelihood of 0.80, assuming an α of 0.05. A conservative estimation of an effect size of 0.7/1.4 changes the N in the power calculation to 59 per group. Hence, we aim to enrol 64 participants in each study arm. We will use intention-to-treat analysis and compare mean HbA1c (% glycosylated HbA1c) (primary outcome) of Intervention/Control participants at 12 months, 24 months and 1 year postintervention on selected clinical, patient-rated and economic measures. Trial registration number NCT02002143. PMID:26169803

  6. 29 CFR 42.4 - Structure of the National Committee.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... responsibilities. (d) There shall be a National Committee staff level working group consisting of senior staff... Secretary shall be the director of the staff level working group. (f) The staff level working group shall...

  7. 12 CFR Appendix C to Part 202 - Sample Notification Forms

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 2 2011-01-01 2011-01-01 false Sample Notification Forms C Appendix C to Part... CREDIT OPPORTUNITY ACT (REGULATION B) Pt. 202, App. C Appendix C to Part 202—Sample Notification Forms 1. This appendix contains ten sample notification forms. Forms C-1 through C-4 are intended for use in...

  8. 12 CFR Appendix C to Part 202 - Sample Notification Forms

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 2 2014-01-01 2014-01-01 false Sample Notification Forms C Appendix C to Part... CREDIT OPPORTUNITY ACT (REGULATION B) Pt. 202, App. C Appendix C to Part 202—Sample Notification Forms 1. This appendix contains ten sample notification forms. Forms C-1 through C-4 are intended for use in...

  9. Nano-jewellery: C5Au12--a gold-plated diamond at molecular level.

    PubMed

    Naumkin, F

    2006-06-07

    A mixed carbon-metal cluster is designed by combining the tetrahedral C(5) radical (with a central atom-the skeleton of the C(5)H(12) molecule) and the spherical Au(12) layer (the external atomic shell of the Au(13) cluster). The C(5)Au(12) cluster and its negative and positive ionic derivatives, C(5)Au(12)(+/-), are investigated ab initio (DFT) in terms of optimized structures and relative energies of a few spin-states, for the icosahedral-like and octahedral-like isomers. The cluster is predicted to be generally more stable in its octahedral shape (similar to C(5)H(12)) which prevails for the negative ion and may compete with the icosahedral shape for the neutral system and positive ion. Adiabatic ionization energies (AIE) and electron affinities (AEA) of C(5)Au(12), vertical electron-detachment (VDE) energies of C(5)Au(12)(-), and vertical ionization and electron-attachment energies (VIE, VEA) of C(5)Au(12) are calculated as well, and compared with those for the corresponding isomers of the Au(13) cluster. The AIE and VIE values are found to be close for the two systems, while the AEA and VDE values are significantly reduced for the radical-based species. A simple fragment-based model is proposed for the decomposition of the total interaction into carbon-gold and gold-gold components.

  10. High-Resolution Study of the C-D Stretching Bands of 12C 6D 6 and 13C 6D 6

    NASA Astrophysics Data System (ADS)

    Pliva, J.; Johns, J. W. C.; Goodman, L.

    1994-01-01

    The perpendicular C-D stretching bands ν 12 (species E1 u) were measured for two isotopomers of benzene with D6 h symmetry. 12C 6D 6 and 13C 6D 6, on a high-resolution Fourier transform spectrometer. Both bands show effects of fairly strong perturbations by states resulting from combinations of low-frequency vibrations. The ν 12 state of 12C 6D 6 is in Fermi resonance with the combination ν 2 + ν 3 whose pP lines, enhanced by the resonance, are observed just below the pP branches of ν 12. An x, y-type Coriolis interaction with an unidentified state of symmetry E2 u, and another anharmonic interaction with an unknown E1 u state, have also been detected in the spectrum. These interactions were included, along with the Fermi resonance and the rotational l-resonance and -doubling, in the Hamiltonian used in the analysis of this band. For the ν 12 band of the 13C 6D 6 isotopomer, a strong perturbation by an anharmonic resonance with the E1 u state ν 7 + ν 11 + ν 14 and a much weaker perturbation. presumably by a z-type Coriolis interaction with an unidentified perturber, have been observed and taken into account in the analysis. Spectroscopic constants are reported for the ν 12 states of the two isotopic species, and parameters obtained for the various perturbers and coupling constants are also listed. It is found that the ζ sum for the E1 u vibrations of all D6 h isotopomers of benzene differs slightly from the theoretical value of ∑ζ t = -1.

  11. Pseudomonas aeruginosa biofilm-associated homoserine lactone C12 rapidly activates apoptosis in airway epithelia

    PubMed Central

    Schwarzer, Christian; Fu, Zhu; Patanwala, Maria; Hum, Lauren; Lopez-Guzman, Mirielle; Illek, Beate; Kong, Weidong; Lynch, Susan V.; Machen, Terry E.

    2014-01-01

    Pseudomonas aeruginosa (PA) forms biofilms in lungs of cystic fibrosis CF) patients, a process regulated by quorum sensing molecules including N-(3-oxododecanoyl)-L-homoserine lactone, C12. C12 (10–100 μM) rapidly triggered events commonly associated with the intrinsic apoptotic pathway in JME (CFΔF508CFTR, nasal surface) epithelial cells: depolarization of mitochondrial (mito) membrane potential (Δψmito) and release of cytochrome C (cytoC) from mitos into cytosol and activation of caspases 3/7, 8 and 9. C12 also had novel effects on the endoplasmic reticulum (release of both Ca2+ and ER-targeted GFP and oxidized contents into the cytosol). Effects began within 5 minutes and were complete in 1–2 hrs. C12 caused similar activation of caspases and release of cytoC from mitos in Calu-3 (wtCFTR, bronchial gland) cells, showing that C12-triggered responses occurred similarly in different airway epithelial types. C12 had nearly identical effects on three key aspects of the apoptosis response (caspase 3/7, depolarization of Δψmito and reduction of redox potential in the ER) in JME and CFTR-corrected JME cells (adenoviral expression), showing that CFTR was likely not an important regulator of C12-triggered apoptosis in airway epithelia. Exposure of airway cultures to biofilms from PAO1wt caused depolarization of Δψmito and increases in Cacyto like 10–50 μM C12. In contrast, biofilms from PAO1ΔlasI (C12 deficient) had no effect, suggesting that C12 from P. aeruginosa biofilms may contribute to accumulation of apoptotic cells that cannot be cleared from CF lungs. A model to explain the effects of C12 is proposed. PMID:22233488

  12. MicroRNA, miR-374b, directly targets Myf6 and negatively regulates C2C12 myoblasts differentiation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ma, Zhiyuan; Sun, Xiaorui; Xu, Dequan

    Myogenesis is a complex process including myoblast proliferation, differentiation and myotube formation and is controlled by myogenic regulatory factors (MRFs), MyoD, MyoG, Myf5 and Myf6 (also known as MRF4). MicroRNA is a kind of ∼22 nt-long non-coding small RNAs, and act as key transcriptional or post-transcriptional regulators of gene expression. Identification of miRNAs involved in the regulation of muscle genes could improve our understanding of myogenesis process. In this study, we investigated the regulation of Myf6 gene by miRNAs. We showed that miR-374b specifically bound to the 3'untranslated region (UTR) of Myf6 and down-regulated the expression of Myf6 gene at bothmore » mRNA and protein level. Furthermore, miR-374b is ubiquitously expressed in the tissues of adult C57BL6 mouse, and the mRNA abundance increases first and then decreases during C2C12 myoblasts differentiation. Over-expression of miR-374b impaired C2C12 cell differentiation, while inhibiting miR-374b expression by 2′-O-methyl antisense oligonucleotides promoted C2C12 cell differentiation. Taken together, our findings identified miR-374b directly targets Myf6 and negatively regulates myogenesis. - Highlights: • MiR-374b directly targets 3′UTR of Myf6. • MiR-374b negatively regulates Myf6 in C2C12 cells. • MiR-374b abundance significiently changes during C2C12 cells differentiation. • MiR-374b negatively regulates C2C12 cells differentiation.« less

  13. The 12C/13C Ratio in Sgr B2(N): Constraints for Galactic Chemical Evolution and Isotopic Chemistry

    NASA Astrophysics Data System (ADS)

    Halfen, D. T.; Woolf, N. J.; Ziurys, L. M.

    2017-08-01

    A study has been conducted of 12C/13C ratios in five complex molecules in the Galactic center. H2CS, CH3CCH, NH2CHO, CH2CHCN, and CH3CH2CN and their 13C-substituted species have been observed in numerous transitions at 1, 2, and 3 mm, acquired in a spectral-line survey of Sgr B2(N), conducted with the telescopes of the Arizona Radio Observatory (ARO). Between 22 and 54 individual, unblended lines for the 12C species and 2-54 for 13C-substituted analogs were modeled in a global radiative transfer analysis. All five molecules were found to consistently exhibit two velocity components near V LSR ˜ 64 and 73 km s-1, with column densities ranging from N tot ˜ 3 × 1014 - 4 × 1017 cm-2 and ˜2 × 1013 - 1 × 1017 cm-2 for the 12C and 13C species, respectively. Based on 14 different isotopic combinations, ratios were obtained in the range 12C/13C = 15 ± 5 to 33 ± 13, with an average value of 24 ± 7, based on comparison of column densities. These measurements better anchor the 12C/13C ratio at the Galactic center, and suggest a slightly revised isotope gradient of 12C/13C = 5.21(0.52) D GC + 22.6(3.3). As indicated by the column densities, no preferential 13C enrichment was found on the differing carbon sites of CH3CCH, CH2CHCN, and CH3CH2CN. Because of the elevated temperatures in Sgr B2(N), 13C isotopic substitution is effectively “scrambled,” diminishing chemical fractionation effects. The resulting ratios thus reflect stellar nucleosynthesis and Galactic chemical evolution, as is likely the case for most warm clouds.

  14. 78 FR 28602 - Merchant Marine Personnel Advisory Committee: Intercessional Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-15

    ... Committee (MERPAC) will meet to work on Task Statement 83, entitled ``Development of competency requirements... the June 11, 2013, working group meeting is as follows: (1) Develop competency requirements to meet... committee to consider with regards to Task Statement 83, entitled ``Development of competency requirements...

  15. Cobalt triggers necrotic cell death and atrophy in skeletal C2C12 myotubes.

    PubMed

    Rovetta, Francesca; Stacchiotti, Alessandra; Faggi, Fiorella; Catalani, Simona; Apostoli, Pietro; Fanzani, Alessandro; Aleo, Maria Francesca

    2013-09-01

    Severe poisoning has recently been diagnosed in humans having hip implants composed of cobalt-chrome alloys due to the release of particulate wear debris on polyethylene and ceramic implants which stimulates macrophagic infiltration and destroys bone and soft tissue, leading to neurological, sensorial and muscular impairments. Consistent with this premise, in this study, we focused on the mechanisms underlying the toxicity of Co(II) ions on skeletal muscle using mouse skeletal C2C12 myotubes as an in vitro model. As detected using propidium iodide incorporation, increasing CoCl2 doses (from 5 to 200μM) affected the viability of C2C12 myotubes, mainly by cell necrosis, which was attenuated by necrostatin-1, an inhibitor of the necroptotic branch of the death domain receptor signaling pathway. On the other hand, apoptosis was hardly detectable as supported by the lack of caspase-3 and -8 activation, the latter resulting in only faint activation after exposure to higher CoCl2 doses for prolonged time points. Furthermore, CoCl2 treatment resulted in atrophy of the C2C12 myotubes which was characterized by the increased expression of HSP25 and GRP94 stress proteins and other typical `pro-atrophic molecular hallmarks, such as early activation of the NF-kB pathway and down-regulation of AKT phosphorylation, followed by the activation of the proteasome and autophagy systems. Overall, these results suggested that cobalt may impact skeletal muscle homeostasis as an inducer of cell necrosis and myofiber atrophy. Copyright © 2013 Elsevier Inc. All rights reserved.

  16. Maryalnd House enironment & Transportation Committee Visit

    NASA Image and Video Library

    2016-11-15

    Center Director Chris Scolese welcomed the Maryland House Environment & Transportation Committee to Goddard on November 15, 2016. The group visited the James Webb Space Telescope JWST, then they toured the Robotics Operations Facility.

  17. A lower limit on the surface C-12/C-13 ratio in Alpha Orionis

    NASA Technical Reports Server (NTRS)

    Gautier, T. N., III; Fink, U.; Larson, H. P.; Thompson, R. I.

    1976-01-01

    The second overtone CO bands near 1.6 microns were analyzed in Alpha Ori using synthetic spectra. No firm identification of (C-13)O was made, which allowed a lower limit of 20 to be set on the C-12/C-13 ratio. A rather low microturbulent velocity of 2 km/s was found to match the spectrum of Alpha Ori best.

  18. 75 FR 3279 - Departmental Offices; Debt Management Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-20

    ... DEPARTMENT OF THE TREASURY Departmental Offices; Debt Management Advisory Committee Meeting Notice is hereby given, pursuant to 5 U.S.C. App. 2, Sec. 10(a)(2), of a time change for a previously... February 2, 2010. The meeting of the following debt management advisory committee: Treasury Borrowing...

  19. 12 CFR 272.3 - Meetings.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Meetings. 272.3 Section 272.3 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) FEDERAL OPEN MARKET COMMITTEE RULES OF PROCEDURE § 272.3 Meetings. (a) Place and frequency. The Committee meets in Washington, DC, at least four times each year and oftener if...

  20. Astrophysical SE2 factor of the 12C(α, γ)16O reaction through the 12C(11B, 7Li)16O transfer reaction

    NASA Astrophysics Data System (ADS)

    Guo, B.; Du, X. C.; Li, Z. H.; Li, Y. J.; Pang, D. Y.; Su, J.; Yan, S. Q.; Fan, Q. W.; Gan, L.; Han, Z. Y.; Li, E. T.; Li, X. Y.; Lian, G.; Liu, J. C.; Pei, C. J.; Qiao, L. H.; Shen, Y. P.; Su, Y.; Wang, Y. B.; Zeng, S.; Zhou, Y.; Liu, W. P.

    2016-02-01

    The 12C(α, γ)16O reaction plays a key role in the evolution of stars with masses of M > 0.55 M⊙. At the Gamow peak (Ec.m. = 300 ke V, T9 = 0.2), the cross section of the 12C(α, γ)16O reaction is so small (about 10-17 barn) that the direct measurement in ground laboratory is not feasible with the existing technology. Up to now, the cross sections at lower energies can only be extrapolated from the data at higher energies. However, two subthreshold resonances, locating at Ex = 7.117 MeV and Ex = 6.917 MeV, make this extrapolation more complicated. In this work the 6.917 MeV subthreshold resonance in the 12C(α, γ)16O reaction was investigated via the 12C(11B, 7Li)16O reaction. The experiment was performed using the Q3D magnetic spectrograph at HI-13 tandem accelerator. We measured the angular distribution of the 12C(11B, 7Li)16O transfer reaction leading to the 6.917 MeV state. Based on DWBA analysis, we derived the square of ANC of the 6.917 MeV level in 16O to be (2.45± 0.28) ×1010 fm-1, with which the reduced-α width can be computed. Finally, we calculated the astrophysical SE2 factor of the 6.917 MeV resonance to be 67.6 ± 7.7 ke V b.

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