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1

Discordant Puberty in Monozygotic Twin Sisters with Neurofibromatosis Type 1 (NFl)  

Microsoft Academic Search

Monozygotic twin sisters are reported who have discordant pubertal growth and sexual development. Although both sisters were physiologically appropriate for chronological age in their pubertal development, their adolescent development was considerably different from that expected of monozygotic twin sisters. The more pubertally advanced sister by magnetic resonance imaging had an optic pathway glioma while none was present in her twin

Thaddeus E. Kelly; George T. Sproul; Milagros G. Huerta; Alan D. Rogol

1998-01-01

2

Episodic deformation within the Twin Sisters ultramafic massif, Washington  

NASA Astrophysics Data System (ADS)

A tectonic history punctuated by distinct pulses of deformation is revealed through detailed mapping and microstructural observations in the central portion of the Twin Sisters ultramafic massif, western Washington. Folded and elongated orthopyroxenite dikes occur in a banded dunite/harzburgite host. Compositional banding is parallel to a high temperature (~1000oC) foliation defined by shape-preferred orientation of elongate chromite and orthopyroxenite grains. Dunites and harzburgites have a bimodal grainsize distribution, dominated by coarse (3-5 mm) olivine grains with finer grains (~1 mm) developed locally along grain boundaries and at triple junctions. Analysis of the distribution, shape and 3-d geometry of the orthopyroxenite dikes, mapped using a laser surveying station at cm-scale accuracy, indicates that the axial planes of the folds are generally parallel to the high-temperature foliation in the host peridotite, while fold hinges are strongly girdled within this axial plane. Fold limbs that strike parallel to the high-temperature host rock foliation are ductilely thinned, or, rarely, boudinaged, with respect to folded portions of the dike. Microstructural observations from one orthopyroxenite dike and the adjacent host dunite vary from limb to hinge. Orthopyroxene grains (5-10 mm) from the hinge area exhibit kinked cleavage planes, minor undulose extinction, subgrain development and new grains (0.1 mm). Analysis using electron backscattered diffraction indicates no crystallographic preferred orientation (CPO) in orthopyroxene grains from the hinge. Orthopyroxene grains (5-10 mm) in the limb contain sweeping undulose extinction, deformation bands, bent cleavage planes, subgrain development, and a higher percentage (~10%) of fine grains (0.1-0.3 mm) than in the hinge area. Coarse orthopyroxene grains from the limb yield a CPO. Olivine grains in the dunite adjacent to the folded dike have a trimodal grainsize distribution; the coarse and intermediate grainsizes are similar to the host peridotite away from the folded dike. The proportion of the finest grainsize (~0.5 mm) population varies from limb to hinge, with a higher percentage observed in samples adjacent to the limb of the fold. These CPO data and microstructural observations suggest higher strains in the limbs of the fold than in the hinge area. These meso- and microscale observations suggest an early stage of deformation that resulted in the high-temperature foliation that is parallel to the harzburgite/dunite banding. The banded and foliated dunites and harzburgites were intruded by orthopyroxenite dikes, under conditions of hydrostatic or very low stresses, resulting in random orientations of the dikes. The dikes crystallized under these low stress conditions, resulting in the lack of CPO that is now preserved in the hinge area of the dike. A second pulse of deformation, parallel to the earlier deformation, resulted in folding and elongation of the dikes. This two-pulse model explains the observation of the axial planes parallel to the earlier high temperature fabric.

Rodriguez, A. L.; Newman, J.; Tikoff, B.

2009-12-01

3

Validity of the zygosity questionnaire and characteristics of zygosity-misdiagnosed twin pairs in the Healthy Twin Study of Korea.  

PubMed

Determining valid zygosity is a basic and important requirement in a twin study, because misdiagnosing zygosity leads to biased results. The Healthy Twin Study has collected data from adult like-sex twins and their families since 2005. In the study, a questionnaire to determine zygosity was developed comprising four questions; one concerning the degree of resemblance, and three concerning the degree of confusion by the resemblance. Among 2,761 individuals (624 twin pairs) of twin and their families, 406 pairs of twins (mean age 38.3, 63.5% women) with both questionnaire and genotype information were selected to examine the validity of the zygosity questionnaire using 16 short tandem repeat markers. We first determined individual zygosity including undetermined category, and then decided the zygosity of a twin pair using a decision tree. Sensitivity of questionnaire diagnosis was 98.8% for monozygotic (MZ) and 88.9% for dizygotic (DZ) twins, and positive predictive value was 97.2% for MZ and 95.0% for DZ. When we compared correctly and wrongly diagnosed twin pairs, misdiagnosed DZ twins (nine pairs) showed striking similarity in stature or obesity even exceeding that of true MZ twins. Our finding suggests that a parsimonious questionnaire method of diagnosing the zygosity will be useful, and adding physical or physiological measurements to a questionnaire of zygosity diagnosis will either confound the correct diagnosis or reduce the efficiency of the study compared with using questionnaire alone or with introducing genotyping. PMID:20477720

Song, Yun-Mi; Lee, Donghun; Lee, Mi Kyoung; Lee, Kayoung; Lee, Hee Jung; Hong, Eun Jung; Han, Bokghee; Sung, Joohon

2010-06-01

4

Birth of healthy female twins after preimplantation genetic diagnosis of cystic fibrosis combined with gender determination  

Microsoft Academic Search

Two healthy sisters with a familial history of mental retardation were referred to our centre for preimplantation genetic diagnosis (PGD). Their two brothers showed severe mental retardation. The molecular basis for their disorder could not be identified, but one of the sisters and the mother presented a highly skewed pattern of X-inactivation reinforcing the likelihood of an X-linked mode of

Pierre F. Ray; Nelly Frydman; Tania Attie ´; Samir Hamamah; Violaine Kerbrat; Gerard Tachdjian; Serge Romana; Michel Vekemans; Arnold Munnich

2002-01-01

5

Cervix smear abnormalities: linking pathology data in female twins, their mothers and sisters  

PubMed Central

Mass screening for cervical cancer precursors has decreased the incidence of cervical cancer in several countries, including the Netherlands. Persistent infections of certain types of human papillomavirus are strongly associated with the development of cervical cancer. A number of factors may affect the liability to infection and subsequent progression to cervical intraepithelial neoplasia and cancer. This paper examines whether genetic factors are involved in explaining individual differences in liability. Data of 3178 women registered with the Netherlands Twin Register were successfully linked to the nationwide Dutch Pathology database that contains all results of mass screening for cervical cancer. The data from mono- and dizygotic twins and their female relatives were used to disentangle the influence of heritable and environmental factors on cervix smear abnormalities. Results showed that differences in cervix smear results clustered within families and resemblance was stronger in monozygotic twins (correlation 0.37, 95% confidence interval: 0.12–0.58) compared with other first-degree relatives (correlation 0.14, 95% confidence interval: ?0.01–0.29). The familial clustering for an abnormal cervix smear is due to shared genetic factors that explain 37% of the variance in liability. The largest proportion of the variation in cervical smear abnormalities is due to unique environmental factors.

Vink, Jacqueline M; van Kemenade, Folkert J; Meijer, Chris J L M; Casparie, Mariel K; Meijer, Gerrit A; Boomsma, Dorret I

2011-01-01

6

Conjoined twins, conception, pregnancy, and delivery: A reproductive history of the pygopagus Blažek sisters (1878-1922)  

Microsoft Academic Search

Conjoined twins represent the most uncommon twinning mechanism in humans, with an incidence approaching 1:100,000 deliveries. Although several conjoined male twins have occasionally been reported, for unexplained reasons most cases of conjoined twins are female. Of all the female conjoined twin sets either documented by medical authorities or referenced in ancient literary sources, in only one case were pregnancy and

E. Scott Sills; Jana Vrbikova; Biljana Kastratovic-Kotlica

2001-01-01

7

Twins  

NSDL National Science Digital Library

This collection of Web sites about twins and twin biology starts with a short feature from The Straight Dope (1), which explains the phenomenon of superfecundation. Next is a more extensive piece from Scientific American (2), offering an interesting look at the role genetics may play in the chance of having fraternal twins. The following Web site contains a brief MSNBC story on the recent findings that fraternal, or nonidentical, twins can share the same placenta (3). The Wisconsin Twin Project at the University of Wisconsin-Madison is a long-scale psychological study focused on "the genetic and environmental influences on normal development of twins in the family context." Visitors to the project's Web site (4) will find detailed information about the ongoing research as well as FAQs for general background information. On the topic of twin studies, the next Web site contains a transcript from a recent Health Report story from the Australian Broadcasting Company's Radio National. The transcript is an interview with a researcher working with the Swedish Twin Registry (the largest twin register in the world), an important resource for studying the "relative importance of genetic and environmental influences for behavioral characteristics and diseases (5). The journal Nature offers an interesting article on how the environment in the womb can have profound effects on a child's future health without altering its DNA sequence (6). The following Web site, created by Varun Tankala, offers an excellent introduction to the phenomenon of conjoined twins (7). And with the final Web site, you need not spend another restless night wondering which Star Wars character is your cosmic twin. Not as frivolous as it might seem, this Web site, created by Jeff Potter, contains a well-accepted personality test developed by a University of California-Berkeley psychologist. Users can take the test, find their Star Wars twin, and help advance the field of psychology while you're at it (8).

8

Sex Difference between Body Composition and Weight-Bearing Bone Mineral Density in Korean Adult Twins: Healthy Twin Study  

Microsoft Academic Search

We performed a monozygotic (MZ) cotwin–control study using the MZ twin pair difference in bone mineral density (BMD) to assess\\u000a the relationship between body composition and BMD at weight-bearing sites. This study controlled for common genetic factors\\u000a and applied only to environmental factors, using 185 MZ twin pairs aged 30–50 years (140 male subjects, 230 female subjects).\\u000a As expected, total lean

Taehun KimJoohon; Joohon Sung; Yun-Mi Song; Kayoung Lee; Sung-Il Cho

2011-01-01

9

Socioeconomic Status and Number of Children Among Korean Women: The Healthy Twin Study  

PubMed Central

Objectives This study aimed to evaluate whether the birth rate is associated with socioeconomic status in the women of the Republic of Korea, where the birth rate is rapidly decreasing. Methods This study included 732 females from the Healthy Twin Study, a family-twin cohort. The participants were classified into 3 socioeconomic groups according to their average income, education, and occupation. The association between socioeconomic status and number of children was assessed using gamma regression analysis with a generalized linear mixed model, adjusting for the age group, smoking/alcohol status, and family relationships. Results The group with the highest education level had significantly fewer children compared with the group with the lowest education level (p=0.004). However, no significant associations were found according to household income level. The non-manual labor group had significantly fewer children compared with those working as homemakers (p=0.008). Conclusions This study aimed to explain the causal relationship between socioeconomic status and number of children. Associations between some socioeconomic status and number of children were found in Korea.

Kim, Jinseob

2013-01-01

10

T-cell analysis in identical twins reveals an impaired anti-follicular lymphoma immune response in the patient but not in the healthy twin.  

PubMed

In lymphomas an innate defect in the T-cell repertoire could account for the impaired tumour-specific immune response; alternatively, the tumour itself could exert an inhibitory effect on the immune system. To address this issue we analysed the T-cell responses against follicular lymphoma (FL) in identical twins as it can be postulated that their overall T-cell repertoire is identical. While differences between the T-cell response of the patient and the healthy twin would point to a tumour-induced T-cell unresponsiveness, impaired responses in both would point to a defective T-cell repertoire. We demonstrated an impaired tumour-specific proliferation (P = 0.035 and P = 0.013) and cytokine release (P = 0.004 and P = 0.0008) of both peripheral blood and tumour-derived T-cells, respectively, in the FL patient compared with the T-cell response of the healthy twin. Moreover, only syngeneic primed T cells were able to directly lyse unmodified FL cells of the patient. These data support previous findings in murine lymphomas and suggest that inhibitory mechanisms during tumour growth, rather than a defective T-cell repertoire, are responsible for the insufficient T-cell response in lymphoma. PMID:11841404

Gitelson, Elena; Spaner, David; Buckstein, Rena; Franssen, Edmee; Hewitt, Karen; Lim, Megan S; Pennell, Nancy; Schultze, Joachim L; Berinstein, Neil L

2002-01-01

11

Acquired liver fat is a key determinant of serum lipid alterations in healthy monozygotic twins.  

PubMed

Objective: The effects of acquired obesity on lipid profile and lipoprotein composition in rare BMI-discordant monozygotic (MZ) twin pairs were studied. Design and Methods: Abdominal fat distribution, liver fat (magnetic resonance imaging and spectroscopy), fasting serum lipid profile (ultracentrifugation, gradient gel-electrophoresis, and colorimetric enzymatic methods), and lifestyle factors (questionnaires and diaries) were assessed in 15 BMI-discordant (within-pair difference [?] in BMI >3 kg/m(2) ) and nin concordant (?BMI <3 kg/m(2) ) MZ twin pairs, identified from two nationwide cohorts of Finnish twins. Results: Despite a strong similarity of MZ twins in lipid parameters (intra-class correlations 0.42-0.90, P < 0.05), concentrations of apolipoprotein B (ApoB), intermediate-density lipoprotein cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein 3a% (HDL3a%), and HDL3c% were higher (P < 0.05) and those of HDL cholesterol, HDL2-C, and HDL2b% were lower (P < 0.01) in the heavier co-twins of BMI-discordant pairs. The composition of lipoprotein particles was similar in the co-twins. When BMI-discordant pairs were further divided into liver fat-discordant and concordant (based on median for ?liver fat, 2.6%), the adverse lipid profile was only seen in those heavy co-twins who also had high liver fat. Conversely, BMI-discordant pairs concordant for liver fat did not differ significantly in lipid parameters. In multivariate analyses controlling for ?subcutaneous, ?intra-abdominal fat, sex, ?smoking and ?physical activity, ?liver fat was the only independent variable explaining the variation in ?ApoB, ?total cholesterol, and ?LDL-C concentration. Conclusions: Several pro-atherogenic changes in the amounts of lipids but not in the composition of lipoprotein particles were observed in acquired obesity. In particular, accumulation of liver fat was associated with lipid disturbances, independent of genetic effects. PMID:23696329

Kaye, S M; Maranghi, M; Bogl, L H; Kaprio, J; Hakkarainen, A; Lundbom, J; Lundbom, N; Rissanen, A; Taskinen, M-R; Pietiläinen, K H

2013-05-21

12

Serotonin transporter binding of [123I]ADAM in bulimic women, their healthy twin sisters, and healthy women: a SPET study  

Microsoft Academic Search

BACKGROUND: Bulimia Nervosa (BN) is believed to be caused by an interaction of genetic and environmental factors. Previous studies support the existence of a bulimia-related endophenotype as well as disturbances in serotonin (5-HT) transmission. We studied serotonin transporter (SERT) binding in BN, and to investigate the possibility of a SERT-related endophenotype for BN, did this in a sample of female

Anu K Koskela; Anna Keski-Rahkonen; Elina Sihvola; Tomi Kauppinen; Jaakko Kaprio; Aapo Ahonen; Aila Rissanen

2007-01-01

13

Joubert Syndrome: Monozygotic Twins With Discordant Phenotypes  

Microsoft Academic Search

We describe three sisters with Joubert syndrome, two of whom are monozygotic twins with highly discordant phenotypes. The twins were born at 34 weeks' gestation with discordant birthweights. Their anatomic, neurologic, and developmental status differs greatly: Twin B is able to walk, run, and is verbal, unlike Twin A who is wheelchair-bound, severely retarded, nonverbal, and autistic. Abnormal eye movements

Hillary R. Raynes; Alan Shanske; Sharon Goldberg; Ronald Burde; Isabelle Rapin

1999-01-01

14

Combined Genome-Wide Linkage and Association Analyses of Fasting Glucose Level in Healthy Twins and Families of Korea  

PubMed Central

This study was undertaken to identify genetic polymorphisms that are associated with the risk of an elevated fasting glucose (FG) level using genome-wide analyses. We explored a quantitative trait locus (QTL) for FG level in a genome-wide study from a Korean twin-family cohort (the Healthy Twin Study) using a combined linkage and family-based association analysis approach. We investigated 1,754 individuals, which included 432 families and 219 pairs of monozygotic twins. Regions of chromosomes 2q23.3-2q31.1, 15q26.1-15q26.3, 16p12.1, and 20p13-20p12.2, were found to show evidence of linkage with FG level, and several markers in these regions were found to be significantly associated with FG level using family-based or general association tests. In particular, a single-nucleotide polymorphism (rs6138953) on the PTPRA gene in the 20p13 region (combined P = 1.8 × 10-6) was found to be associated with FG level, and the PRKCB1 gene (in 16p12.1) to be possibly associated with FG level. In conclusion, multiple regions of chromosomes 2q23.3-2q31.1, 15q26.1-15q26.3, 16p12.1, and 20p13-20p12.2 are associated with FG level in our Korean twin-family cohort. The combined approach of genome-wide linkage and family-based association analysis is useful to identify novel or known genetic regions concerning FG level in a family cohort study.

Suh, Young Ju; Kim, SungHwan; Kim, So Hun; Park, Jia; Lim, Hyun Ae; Park, Hyun Ju; Choi, Hangseok; Ng, Daniel; Lee, Mi Kyeong

2013-01-01

15

Reunited twins: spouse relations / twin research reports / timely topics.  

PubMed

The present article explores the social attraction that may evolve on the part of reared apart twins' spouses toward their brothers- and sisters-in-law, that is, their spouses' newly found co-twin. This topic was inspired by the fascinating story of monozygotic reared apart (MZA) twins who were reunited in Perth, Australia in 2008, at age 50. It is followed by brief reviews of twin research articles concerning divorce rates among mothers of multiples and X-chromosome inactivation in MZ female twin pairs. The final section presents informative human interest stories involving twins. PMID:21623660

Segal, Nancy L

2011-06-01

16

Middle Sister and Hayden Glacier  

USGS Multimedia Gallery

The North face of Middle Sister and Hayden Glacier, in Three Sisters Wilderness, Deschutes National Forest, Oregon. This Picture was taken while climbing Middle Sister. Middle Sister is also known as "Hope" and is an extinct stratovolcano....

2009-12-08

17

Sister Wendy's American Collection  

NSDL National Science Digital Library

In conjunction with the broadcast of "Sister Wendy's American Collection" on public television, PBS online hosts this educational Website. Sister Wendy is a Reverend Mother and scholar of English who began studying art during her stay with the Carmelite nuns of Quindenham, Norfolk. She now has a popular television and book series in which she shares her "signature blend of intellect, reverence, and admiration for great works of art." Her latest project explores American museum collections. The Website furnishes color images of the works accompanied by Sister Wendy's equally colorful commentary, background on the artists, plus a guide to the six museums featured. The diverse international selection of art and artifacts includes a Native American earthen bowl, an African drum, Egyptian statuary, as well as an array of classical to contemporary paintings and drawings.

2001-01-01

18

The Prodigal Sister - Venus  

NASA Astrophysics Data System (ADS)

If you think Venus is a hellhole now, be thankful you weren't there 500 million years ago. Those were the days, many planetary scientists believe, of apocalypse on our sister world: Volcanoes wracked the land, while greenhouse gases broiled the air. Is this the Earth's fate, too?

Barlow, Nadine G.

1995-09-01

19

The Prodigal Sister - Venus  

Microsoft Academic Search

If you think Venus is a hellhole now, be thankful you weren't there 500 million years ago. Those were the days, many planetary scientists believe, of apocalypse on our sister world: Volcanoes wracked the land, while greenhouse gases broiled the air. Is this the Earth's fate, too?

Nadine G. Barlow

1995-01-01

20

Alzheimer's Disease Risk Gene, GAB2, is Associated with Regional Brain Volume Differences in 755 Young Healthy Twins  

PubMed Central

The development of late-onset Alzheimer’s disease (LOAD) is under strong genetic control and there is great interest in the genetic variants that confer increased risk. The Alzheimer’s disease risk gene, growth factor receptor bound protein 2-associated protein (GAB2), has been shown to provide a 1.27–1.51 increased odds of developing LOAD for rs7101429 major allele carriers, in case-control analysis. GAB2 is expressed across the brain throughout life, and its role in LOAD pathology is well understood. Recent studies have begun to examine the effect of genetic variation in the GAB2 gene on differences in the brain. However, the effect of GAB2 on the young-adult brain has yet to be considered. Here we found a significant association between the GAB2 gene and morphological brain differences in 755 young-adult twins (469 females) (M = 23.1, SD = 3.1 years), using a gene-based test with principal components regression (PCReg). Detectable differences in brain morphology are therefore associated with variation in the GAB2 gene, even in young adults, long before the typical age of onset of Alzheimer’s disease.

Hibar, Derrek P.; Jahanshad, Neda; Stein, Jason L.; Kohannim, Omid; Toga, Arthur W.; Medland, Sarah E.; Hansell, Narelle K.; McMahon, Katie L.; de Zubicaray, Greig I.; Montgomery, Grant W.; Martin, Nicholas G.; Wright, Margaret J.; Thompson, Paul M.

2013-01-01

21

Brothers and Sisters  

Microsoft Academic Search

Influences in contemporary society such as blended families created by remarriage, international adoptions, and reproductive\\u000a technology have expanded the definition of sibling relationships. Bonds with brothers and sisters occur early and exert a\\u000a profound effect on young children’s overall development. This chapter synthesizes the research on sibling relationships in\\u000a early childhood, identifies four recurring themes, and offers research-based recommendations to

Mary Renck Jalongo; Denise Dragich

22

Sister Nivedita and Her \\  

Microsoft Academic Search

Cet article a pour but de jeter une lumière sur les influences mutuelles exercées entre Okakura Kakuzo, dit Tenshin (1862-1913), et Sister Nivedita (1866-1911), qui édita les manuscrits du premier lors du séjour indien d'Okakura (1901-02). La confrontation textuelles des passages pertinents des Idéaux de l'Orient (publié en 1904) ou de l'Éveil de l'Orient (manuscrit rédigé en 1902) d'avec les

Shigemi Inaga

2004-01-01

23

Differential development of autistic symptoms in a pair of fraternal twins  

Microsoft Academic Search

The following case study reports the differential development of autistic symptoms over a 9-year period in a pair of fraternal twins. Neither of the twins developed normally. Evaluations revealed that although the older (male) twin showed some early signs of pathology and suffered from frequent illnesses, he ultimately has developed more normally than his sister, who likely sustained brain damage

Jerry L. Sloan

1978-01-01

24

The sisters of mindfulness.  

PubMed

This article introduces the issue of Journal of Clinical Psychology: In Session entitled "Beyond Meditation: Mindfulness-Related Clinical Practices." In the article, I describe how the "sisters of mindfulness"-forgiveness, gratitude, loving-kindness, compassion, acceptance, and best-self visualization-are each interconnected and important forms of mindfulness as well as tenets of Buddhist psychology. Each of these practices reflect mental strengths that are being integrated into the brain's neuroplastic development as a function of modern day psychotherapy. PMID:23775372

Rosenzweig, Debra

2013-06-17

25

Umbilical Cord Cyst in a Monochorionic Twin Pregnancy: An Experiment of Nature for the Treatment of Twin-Twin Transfusion Syndrome  

Microsoft Academic Search

A patient with a monochorionic twin pregnancy developed signs of twin-twin transfusion syndrome from 18 weeks of gestational age. At 23 weeks, an umbilical cord cyst and absent diastolic umbilical artery flow were noted in the donor twin. The pregnancy progressed uncomplicated until term and resulted in vaginal delivery of 2 healthy male babies at 38 weeks of gestational age.

Y. Jacquemyn; D. Markov; I. Beckstedde

2002-01-01

26

Sister-sister incest: data from an anonymous computerized survey.  

PubMed

Retrospective data were entered anonymously by 1,521 adult women using a computer-assisted self-interview. Thirty-one participants were victims of sister-sister incest, 40 were victims of brother-sister incest, 19 were victims of father-daughter incest, 8 were victims of sexual abuse by an adult female (including one mother), and 232 were victims of sexual abuse by an adult male other than their father before reaching 18 years of age. The rest (1,203) served as controls. The victims of sister-sister incest had significantly more problematic outcomes than controls on many measures as adults. Victims of sister-sister incest were more depressed and more likely than controls to be distant from the perpetrator-sister and to have traded sex for money, experienced an unplanned pregnancy, engaged in four different types of masturbation, and engaged in 13 different same-sex behaviors. Our findings were consistent with other reports of early eroticization and persistent hypereroticization of incest victims. PMID:23924178

Stroebel, Sandra S; O'Keefe, Stephen L; Griffee, Karen; Kuo, Shih-Ya; Beard, Keith W; Kommor, Martin J

2013-01-01

27

[Adult twins].  

PubMed

This paper explores the deep roots of closeness that twins share in their youngest age and their effect on their destiny at the adult age. Psychologists believe the bond between twins begins in utero and develops throughout the twins' lives. The four patterns of twinship described show that the twin bond is determined by the quality of parenting that twins receive in their infancy and early childhood. Common problems of adult twins bring about difficulties to adapt in a non-twin world. The nature versus nurture controversy has taken on new life focusing on inter-twin differences and the importance of parent-child interaction as fundamental to the growth and development of personality. PMID:17352324

Charlemaine, Christiane

2006-12-31

28

Twin delivery  

Microsoft Academic Search

The incidence of twin pregnancy has increased worldwide over the past 10 years largely as a consequence of the assisted reproductive technologies. Issues such as intrapartum monitoring and operative interventions, especially with regard to the second twin, provide a unique challenge in labour and delivery. Epidemiological data suggest that the term twin has a threefold higher mortality rate than the

J. F. R. Barrett; W. Knox Ritchie

2002-01-01

29

Sister Cities International  

NSDL National Science Digital Library

People from around the world have sought to establish links with other individuals from different nations, and since 1956, cities have sought to also establish meaningful relationships with other urban areas through the Sister Cities International organization. Currently, the organization represents more than 2,500 communities in 126 countries. Visitors to the site can learn which cities are currently seeking partnerships with other cities, read about the organization's annual conference, and also read about the programs they administer. Also, its calendar of events is quite full with programs designed for the general public, such as those dealing with relationships with countries in the Middle East and the question of local government. Finally, the material on the site is available in a number of different languages, including French, German, Spanish, and Japanese.

30

Heritability of Eating Behavior Assessed Using the DEBQ (Dutch Eating Behavior Questionnaire) and Weight-related Traits: The Healthy Twin Study  

Microsoft Academic Search

The heritability of eating behavior and body weight–related traits in Asian populations has not been reported. The purpose of this study was to estimate the heritability of eating behavior and the body weight–related traits of current weight and self-reported past weight among twins and their families. Study subjects were 2,144 Korean, adult, same-sex twins and their families at the ages

Joohon Sung; Kayoung Lee; Yun-Mi Song; Mi Kyeong Lee; Dong-Hun Lee

2010-01-01

31

Where are Sedna's Sisters?  

NASA Astrophysics Data System (ADS)

Simulations of the formation of the Oort cloud from the Kuiper Belt typically are presented as an animated scatter diagram. Here the orbit of each object appears as a point of perihelion distance q and semi-major axis a. (eg. Levison, Morbidelli, & Dones 2004). These plots show a conspicuous void, bounded by the inequalities: q < a, q > 50 AU, and a < 5000-10000 AU. Brown (2005) calls this void the ``Bermuda Triangle". The only present occupant is Sedna (q=76 AU, a=501 AU). Brown, Trujillo, & Rabinowitz , the discovers of Sedna, have challenged others to explain how Sedna got inside the triangle and to predict where similar objects might be found. Sedna could not have simply formed in its current orbit by the accumulation of smaller objects (Stern 2005). Several authors have suggested that a passing star scattered Sedna into the triangle shortly after the birth of the solar system. Here I offer an alternative which uses the very strong galactic tidal forces of the Sinusoidal potential (Bartlett 2001, 2004). In this potential, the numerator of Newton's law is replaced by GM cos(ko r) where ko = 2 ? / lambdao and the 'wavelength' ? o is 425 pc. The 20 radial oscillations between the sun and the center of the Galaxy give tidal forces that are 120 times as big as generally expected. I will show how this tidal force, acting over the lifetime of the solar system, could move the perihelion of Sedna from about 40 to 76 AU. Sedna's sisters are likely to have still larger q & a and to have perihelia in two specific quadrants of the ecliptic plane.

Bartlett, D. F.

2005-05-01

32

Twin-twin transfusion syndrome.  

PubMed

Twin-twin transfusion syndrome (TTTS) is a serious condition that affects 10% to 15% of twin pregnancies with monochorionic diamniotic placentation. The pathophysiology of TTTS is not completely understood; however, the presence of unbalanced placental vascular communications within a shared circulation has been implicated in its development. The presentation of TTTS is highly variable, and it does not always progress in a predictable manner. Monochorionic twin gestations should, therefore, be monitored for signs of TTTS with serial sonograms starting in the second trimester. Early TTTS can be managed conservatively. However, without intervention, early-onset advanced TTTS is associated with a high perinatal loss rate and risk of severe neurologic impairment among survivors. Limited studies suggest that fetoscopic laser photocoagulation is the best available treatment for advanced TTTS diagnosed in the second trimester. Even with laser therapy, there remains a significant risk of twin demise and neurologic handicap in survivors. PMID:22713499

Mosquera, Claudia; Miller, Russell S; Simpson, Lynn L

2012-06-01

33

Twin delivery.  

PubMed

The incidence of twin pregnancy has increased worldwide over the past 10 years largely as a consequence of the assisted reproductive technologies. Issues such as intrapartum monitoring and operative interventions, especially with regard to the second twin, provide a unique challenge in labour and delivery. Epidemiological data suggest that the term twin has a threefold higher mortality rate than the singleton. It is the authors' view that many aspects of twin delivery deserve as much import as those features of twin gestations such as pre-term birth and intrauterine growth restriction that, to date, have received much of the research and clinical interest in this area. Indications for elective Caesarean section are presented, incorporating new data derived from the delivery of the term singleton breech, and implications on the timing thereof are discussed. Vaginal delivery of both twins presenting by the vertex is recommended as safe as long as guidelines for the conduct of such delivery are followed. The recommended time interval between twins as well as the use of epidural, fetal monitoring and ultrasound in the delivery room are discussed. The second twin presenting as a non-vertex presents an urgent dilemma for accoucheurs. Data suggest that internal version and breech extractions are safer than external cephalic version provided that the appropriate techniques are applied. It is revealed, however, that the use of elective Caesarean section in this group of babies has not been subject to randomized controlled studies of sufficient power to determine the best method of delivery of the second twin - particularly in the low-birth-weight baby. PMID:11866496

Barrett, J F R; Ritchie, W Knox

2002-02-01

34

Novel Variants in Growth Differentiation Factor 9 in Mothers of Dizygotic Twins  

Microsoft Academic Search

Context: Genes from the ovarian bone morphogenetic signaling path- way (GDF9 and BMP15) are critical for normal human fertility. We previously identified a deletion mutation in GDFS in sisters with spontaneous dizygotic (DZ) twins, but the prevalence of rare GDFS variants in twinning families is unknown. Objective: The objective was to evaluate the frequency of rare vari- ants in GDFS

James S. Palmer; Zhen Zhen Zhao; Chantal Hoekstra; Nicholas K. Hayward; Penelope M. Webb; David C. Whiteman; Nicholas G. Martin; Dorret I. Boomsma; David L. Duffy; Grant W. Montgomery

35

Conjoined Twins  

MedlinePLUS

... to find cures for tomorrow References Gabbe SG, et al. Obstetrics: Normal and Problem Pregnancies. 6th ed. ... 0.html. Accessed Feb. 10, 2013. Wen XR, et al. Thoraco-omphalopagus conjoined twins: Impact of ultrasound ...

36

Conjoined twins  

Microsoft Academic Search

Conjoined twins occur 1 in 200 000 live births with females predominating 3:1. The twins are classified according to their most prominent site of union together with the suffix ‘pagus’. The diagnosis can be suspected on prenatal scan as early as 12 weeks gestation. A recent advance is the use of 3-D MRI imaging to provide accurate anatomical details prenatally.Management

L. Spitz

2001-01-01

37

Fulfilling the sisters' promise. The heritage of healthcare's early days.  

PubMed

Members of religious orders--the sisters--built not just Catholic healthcare, but healthcare in America. A good 50 years before Henry and Edgar Kaiser got the idea, prepaid capitated health insurance was being offered by sisters who looked at what was needed and realized this was simply the best way to get it done. The sisters also created the integrated healthcare system at a time when the emerging medical elite wanted nothing to do with any patient who was not socially acceptable and potentially curable. They arranged a continuum of care for the aging sisters within their own communities. And they understood the concept of social medicine, of population-based healthcare, of healthy communities, long before these ideas became commonplace. But the sisters are gone, most of them. The question today is, How do we preserve the sisters' heritage and transfer it to a new millennium, a new healthcare system, and a new set of rules? First, it is important to understand that much of what we remember the sisters for--courage, compassion, vision-was not unique. They created many of the structures that today are the new models; but they were not alone. However, three aspects of how they expressed their vision and their faith were unique to the sisters and must be understood by those who wish to treat the path the sisters blazed. The purity of their commitment and its underlying philosophy--that the helpless and the sick must always be the point of the exercise--should pervade Catholic healthcare to its soul. These women, living in poverty, represented, and still represent, a singular group: a group of women who, having told the world that their only wish is to serve others, humble became CEOs of vast systems and trustees of huge enterprises, without ever abandoning that simple, original pledge. Although they bowed to the rule of obedience, and they were humble, the were fighters. They spoke out against poverty, bigotry, the shunning of those with certain diseases, lack of access to healthcare, stupidity, ignorance, and hate. PMID:10165751

Friedman, E

38

A Tale of Two Sisters  

ERIC Educational Resources Information Center

|How many children benefit in many diverse ways through art and/or design? Their personalities may draw different benefits and attributes, but that attests to its wide scope. This article relates a brief story of two sisters. The author describes how the siblings' different personalities played a role in their success.|

Caouette, Ralph

2009-01-01

39

Ossification of the posterior longitudinal ligament in dizygotic twins with schizophrenia: a case report  

Microsoft Academic Search

The pathogenesis of ossification of the posterior longitudinal ligaments (OPLL) has not been clarified. We here report dizygotic\\u000a twin sisters with OPLL of the cervical spine and propose a new pathogenesis of OPLL. This is the first report of dizygotic\\u000a twins with OPLL. The twins suffered from schizophrenia, which might be related to the pathogenesis of OPLL. In addition, we

Shunji Matsunaga; Hiroaki Koga; Naoya Kawabata; Ichiro Kawamura; Masaki Otusji; Takanori Imakiire; Setsuro Komiya

2008-01-01

40

Chromosome cohesion: ring around the sisters?  

Microsoft Academic Search

Sister chromatid cohesion is a key aspect of accurate chromosome transmission during mitosis, yet little is known about the structure of cohesin, the protein complex that links the two sister chromatids. Recent studies shed light on the structure of the cohesin complex, leading to intriguing models that could explain how sister chromatids are held together.

Joseph L Campbell; Orna Cohen-Fix

2002-01-01

41

Sleep-related eating disorder in fraternal twins  

Microsoft Academic Search

Sleep-related eating disorder (SRED) is characterized by nocturnal partial arousals associated with compulsive consumption of food and altered levels of consciousness. Reports of an increased incidence of SRED in relatives of affected individuals suggest a genetic predisposition. We report a woman with SRED whose fraternal twin sister and father are also affected.

Joel De Ocampo; Nancy Foldvary; Dudley S Dinner; Joseph Golish

2002-01-01

42

Twin differences in intelligence  

Microsoft Academic Search

The Stanford-Binet test was given to 16 pairs of identical twins (reared together) and to 5 pairs of fraternal twins (reared together). The mean percentage of agreement of sub-tests was .956 ± .013 for identical twins and .760 ± .039 for fraternal twins, thus substantiating a notion that identical twins make the same errors on the test. Interpretation of the

D. C. Rife

1935-01-01

43

Twin-to-twin transfusion syndrome (TTTS).  

PubMed

Twin-to-twin transfusion syndrome (TTTS) is a severe complication of monochorionic (MC) twin pregnancies, characterized by the development of unbalanced chronic blood transfer from one twin, defined as donor twin, to the other, defined as recipient, through placental anastomoses. If left untreated, TTTS is associated with very high perinatal mortality and morbidity rates, due to a combination of fetal and/or obstetric complications. The reported prevalence is 10-15% of all MC twins, or about 1 in 2000 pregnancies. This consensus document reviews available evidence and offers practical guidance to clinicians by providing recommendations on various aspects concerning diagnosis and management of TTTS. PMID:21142846

Baschat, Ahmet; Chmait, Ramen H; Deprest, Jan; Gratacós, Eduard; Hecher, Kurt; Kontopoulos, Efficia; Quintero, Ruben; Skupski, Daniel W; Valsky, Dan V; Ville, Yves

2010-12-13

44

Twin-to-twin transfusion syndrome  

MedlinePLUS

... Lim FY, Crombleholme T. Twin-to-twin transfusion syndrome: a comprehensive update. Clin Perinatol . 2009 Jun;36(2):391-416, x. Cunningham FG, Leveno KJ, Bloom SL, et al. Multifetal gestation. In: Cunnigham FG, ...

45

Sister to Sister: Everyone Has a Heart Foundation  

MedlinePLUS

... Medications Girlfriends' Guide to Heart Health Health Tools Heart Risk Assessment BMI Calculator Resource Guide Affordable Care Act Resources Glossary myHeartHealth Heart Risk Assessment Heart Healthy Blog Daily Tips Inspired Stories ...

46

Twins: A cloning experience  

Microsoft Academic Search

Drawing upon qualitative interviews with monozygotic (identical) twins sharing 100% of their genes, and with dizygotic (fraternal) twins and singletons as control groups, this paper explores what it means to be genetically identical. (The twins interviewed were from the TwinsUK register in London.) In the context of the ongoing debate on human reproductive cloning, it examines questions such as: To

Barbara Prainsack; Tim D. Spector

2006-01-01

47

Increased sister chromatid exchanges in peripheral lymphocytes of patients with Crohn's disease  

Microsoft Academic Search

A cytogenetic study was performed using Crohn's disease patients to determine whether the presence of chromosome instability is related to Crohn's disease, a chronic inflammatory bowel disease. Sister chromatid exchange (SCE) frequencies in peripheral blood lymphocyte cultures from 22 Crohn's disease patients and an equal number of healthy controls matched for sex and age were analyzed. The mean of SCE

Myung-Hee Kang; Dieter Genser; Ibrahim Elmadfa

1997-01-01

48

[Sudden death of two sisters in a family with combined progressive impairment of cardiac conduction system].  

PubMed

Sudden cardiac death (SCD) of two sisters from a family with combined progressive impairment of cardiac conduction system (CCS) is described. These two sisters (hetero-ovular twins) died suddenly in a kindergarten at the background of physical and emotional effort in the age of 4.8 and 5 years. Resuscitation and electrical defibrillation conducted in one of them after 20 min of heart arrest were not effective. Autopsy gave no clear-cut data relative to pathology of the heart and other organs. Analysis of preserved ECGs showed that in the age of 8 months both sisters had sharp leftward/upward deviation of electric axis of the heart (-41 in one sister and -43 in another). In 2 years these deviations became even more pronounced reaching -63. This was combined with small q-waves and tall R waves in leads I and aVL what corresponded to signs of block of the anterior branch of bundle of His and could be a manifestation of hereditary disease with progressive CCS involvement first of all of the Lev-Lenegre disease. PMID:23098357

Makarov, L M; Komoliatova, V N; Kolosov, V O; Solokhin, Iu A

2012-01-01

49

All in the Family: The Sister Study  

MedlinePLUS

Skip Navigation Bar Home Current Issue Past Issues All in the Family: The Sister Study Past Issues / ... that may ultimately eliminate this dreaded disease. We all know that breast cancer does not discriminate. Whether ...

50

Volumes of Brain Structures in Twins Discordant for Schizophrenia  

Microsoft Academic Search

Background: The study was designed to examine the relative contributions of genetic and nongenetic factors to structural brain abnormalities in schizophrenia and subjects at risk to develop the disorder. Methods: The brains of 15 monozygotic and 14 same- sex dizygotic twins discordant for schizophrenia (pa- tients) and 29 healthy twins pair-wise matched for zygosity, sex, age, and birth order were

William F. C. Baare; Mm Sitskoorn; Hilleke E. Hulshoff Pol; Hugo G. Schnack; Sarah Durston; Rene S. Kahn

2001-01-01

51

First trimester diagnosis of forked cord in monoamniotic twin pregnancy.  

PubMed

A 29-year-old healthy woman at 10 weeks gestation was suspected for monoamniotic twin pregnancy, thus referred for evaluation and treatment. Ultrasound examination confirmed intrauterine monoamniotic twin gestation with central insertion of both umbilical cords by brief conjoined part (9 mm) - comprising a forked umbilical cord. Early diagnosis, planned prenatal care and close surveillance allowed preventing perinatal mortality. PMID:21959059

Frisch, L; Groisman, G; Hallak, M

2011-09-28

52

Seasonal changes, sleep length and circadian preference among twins with bipolar disorder  

Microsoft Academic Search

BACKGROUND: We aimed at studying the seasonal changes in mood and behaviour, the distribution of hospital admissions by season, and the persistence of the circadian type in twins with bipolar disorder and their healthy co-twins. METHODS: All Finnish like-sex twins born from 1940 to 1969 were screened for a diagnosis of bipolar type I disorder. The diagnosis was assessed with

Reeta Hakkarainen; Carolina Johansson; Tuula Kieseppä; Timo Partonen; Markku Koskenvuo; Jaakko Kaprio; Jouko Lönnqvist

2003-01-01

53

Preparing for Twins  

MedlinePLUS

... to be in separate classes. Balancing The Dual Identities of Twins As much as you appreciate the ... and are themselves bound to develop a dual identity—as individuals and as twins. Helping them understand ...

54

Plantar warts in twins after successful bone marrow transplantation for severe combined immunodeficiency.  

PubMed

Nine-year-old twin sisters presented with long-standing severe plantar warts following bone marrow transplantation for severe combined immunodeficiency (SCID). Combination therapy with keratolysis, cidofovir and water-filtered infrared coagulation (WIRA) led to complete clearance after 8 months of therapy. This dermatologic problem and the treatment of SCID including gene therapy are discussed. PMID:16686610

Marini, Alessandra; Niehues, Tim; Stege, Helger; Ruzicka, Thomas; Hengge, Ulrich R

2006-05-01

55

Haemodynamic model of twin-twin transfusion syndrome in monochorionic twin pregnancies  

Microsoft Academic Search

Twin-twin transfusion syndrome in monochorionic twin pregnancies is not understood completely and is controversial which hampers development of acceptable diagnostic and rational treatment strategies. A haemodynamic model was developed that relates fetal growth with (1) fetoplacental blood flow and fetomaternal effects, and (2) net twin-twin transfusion from donor to recipient twin. Fluid balance mechanisms were neglected. Placental vascular anastomoses (arteriovenous,

M. J. C. van Gemert; H. J. C. M. Sterenborg

1998-01-01

56

Genital divergence in sympatric sister snails.  

PubMed

A pattern of greater divergence in mating traits between sister-species pairs with overlapping ranges than between allopatric species pairs is expected if reinforcement commonly contributes to speciation. Few large-scale comparative analyses have addressed this prediction, especially for genital form. Here, we show that penial morphology follows the predicted pattern in 40 robustly identified sister-species pairs in the marine gastropod subfamily Littorininae. Further work is needed to exclude other processes that may contribute to genital divergence between sympatric species, but the clear pattern we observe strongly suggests a role for genital form in reproductive isolation in this large clade. PMID:23163483

Hollander, J; Smadja, C M; Butlin, R K; Reid, D G

2012-11-19

57

Twin Paradox Program  

NSDL National Science Digital Library

The Twin Paradox program displays the effect of time dilation on a moving twin as seen from a stationary twin. In the default scenario the light signals sent from the moving twin are depicted using a spacetime diagram and are shown as seen in the stationary twinâs reference frame (the Home Frame). The sliders can be used to change the twinâs trip distance and her trip speed relative to the stationary twin. Twin Paradox is an Open Source Physics program written for the teaching of special relativity. It is distributed as a ready-to-run (compiled) Java archive. Double clicking the sr_twin.jar file will run the program if Java is installed. Other special relativity programs are also available. They can be found by searching ComPADRE for Open Source Physics, OSP, or Relativity.

Simov, Kiril; Christian, Wolfgang

2008-05-30

58

A rare anomaly in twin pregnancy--a cardiac twin.  

PubMed

Twin reversed arterial perfusion syndrome is the extreme manifestation of twin to twin transfusion syndrome. The pathogenesis is thought to be reversed arterial transfusion. Acardiac foetus grossly features severe reduction anomalies particularly of the upper body. Although the acardiac twin is nonviable, it can cause severe obstetric, foetal and maternal complications. Here, one such case of acardiac twin in reported. PMID:23936962

Patra, Sharmishtha; Gupta, Jayanta Kumar; Patra, Rishavdeb

2012-12-01

59

Long term outcome of twin-twin transfusion syndrome  

Microsoft Academic Search

AIMSTo compare the perinatal mortality and morbidity of infants with twin-twin transfusion syndrome (TTTS) with those of gestation matched twin controls and to assess the neurodevelopmental outcome of surviving twins with TTTS.METHODSA cohort of 17 consecutive pregnancies with TTTS was enrolled over three years together with gestation matched twin pregnancies unaffected by TTTS. Serial amnioreduction for the TTTS pregnancies was

R B Cincotta; P H Gray; G Phythian; Y M Rogers; F Y Chan

2000-01-01

60

CELL CYCLE: The Difficulty in Separating Sisters  

NSDL National Science Digital Library

Access to the article is free, however registration and sign-in are required. The separation of the tightly associated sister chromatids during the anaphase step of cell division is an intricately orchestrated event. Orr-Weaver, in her Perspective, discusses new findings by Zou et al. in this issue that reveal the underlying molecular machinery involved.

Terry L. Orr-Weaver (Whitehead Institute and the Massachusetts Institute of Technology;)

1999-07-16

61

[Color perception in twins].  

PubMed

The classical twin method was used to examine the genotype--phenotype relationship in color vision. Suprathreshold color differences were assessed by 5 pairs of monozygotic (MZ) and 3 pairs of dizygotic (DZ) twins. The control group included 3 unrelated normal trichromats, a non-twin sibling pair, and a previously diagnosed deuteranomal. Concordance rates were calculated by Spearman's correlation coefficients (rs) and Procrustean distances (gl) between the reconstructed color spaces for each related pair of observers. For 4 pairs of the MZ twins, the rs values were comparable to intraindividual variability in the control normal trichromat; they were significantly higher (0.94-0.97) than those for the DZ twins and siblings (0.72-0.82). The gl values for the MZ twins (0.008-0.029) were lower than for the DZ twins (0.073-0.079) and siblings (0.053). The high concordance between each pair of the MZ twins suggests that their shared photopigment genome constrains a contribution of possible individual variations in nongenetic factors to variability of their color spaces. Lower concordance rates in the DZ twins and siblings can be attributed to differences in the inherited arrays of photopigment genes. Contributions to intrapair variation in color spaces of twins from cognitive factors such as perceptual-cognitive color categorization and decision-process variability are discussed. PMID:11084998

Paramei, G V; Bimler, D L; Mislavskaia, N O

62

Splitting the Chromosome: Cutting the Ties That Bind Sister Chromatids  

NSDL National Science Digital Library

In eukaryotic cells, sister DNA molecules remain physically connected from their production at S phase until their separation during anaphase. This cohesion is essential for the separation of sister chromatids to opposite poles of the cell at mitosis. It also permits chromosome segregation to take place long after duplication has been completed. Recent work has identified a multisubunit complex called cohesin that is essential for connecting sisters. Proteolytic cleavage of one of cohesin's subunits may trigger sister separation at the onset of anaphase.

Kim Nasmyth (Research Institute of Molecular Pathology ;); Jan-Michael Peters (Research Institute of Molecular Pathology ;); Frank Uhlmann (Research Institute of Molecular Pathology ;)

2000-05-26

63

Agenesis of the Corpus Callosum in Two Sisters  

Microsoft Academic Search

Two sisters are described. They are offspring of Arabic parents who are both first and second cousins, through both sets of grandparents; additionally the father's parents are first cousins. The diagnosis of agenesis of the corpus callosum in the propositae was made by the characteristic picture on the pneumoencephalogram.The clinical symptoms in the two sisters varied considerably. The older sister

Yehuda Shapira; Tirza Cohen

1973-01-01

64

Sisters of St. Joseph College Consortium: Mission and Image.  

ERIC Educational Resources Information Center

As part of a process of discerning the future direction and mission of the Sisters of Saint Joseph College Consortium (SSJCC), a year-long study of 11 institutions founded and run by the Sisters of Saint Joseph was undertaken. Sisters of Saint Joseph (SSJ) is a Roman Catholic women's religious congregation founded in 1836 which operates a…

Miller, Kathryn

1995-01-01

65

Oesophageal atresia in twins  

Microsoft Academic Search

The twin incidence is higher in infants with oesophageal atresia (OA) than in the general population. The purpose of this\\u000a study was to review the twin OA information from five institutions and evaluate possible links between the development of\\u000a OA and the twinning process. Data were compared, combined, and analysed. There was a total of 1215 infants with OA, of

J. Orford; M. Glasson; S. Beasley; E. Shi; N. Myers; D. Cass

2000-01-01

66

In the company of my sisters: Sister circles as an anxiety intervention for professional African American women  

Microsoft Academic Search

BackgroundSister circles have been used within African American communities to raise awareness about physical health. The possibility exists that sister circles could be used to educate and teach women strategies about managing anxiety and panic. In this paper we examine professional Black women's conceptualization of panic attacks and other related anxiety issues. Then, we explore the feasibility of sister circles

Angela M. Neal-Barnett; Robert Stadulis; Margaret Ralston Payne; Lori Crosby; Monica Mitchell; Lakisha Williams; Crystal Williams-Costa

2011-01-01

67

Risk for surviving twin after fetal death of co-twin in twin–twin transfusion syndrome  

Microsoft Academic Search

Objective: To determine neonatal outcome of surviving twins in pregnancies complicated by twin–twin transfusion syndrome and fetal deaths of co-twins.Methods: We retrospectively reviewed medical records of 11 women seen during 1990–1996 in our hospital who had pregnancies complicated by twin–twin transfusion syndrome and death of one fetus.Results: The median interval between fetal death and delivery (six by cesarean delivery and

Cathelijne F. van Heteren; Jan G. Nijhuis; Ben A. Semmekrot; Leon G. M. Mulders; Paul P. van den Berg

1998-01-01

68

Monochorionic dizygous twins presenting with blood chimerism and discordant sex.  

PubMed

Monochorionic dizygous twins are probably more frequent than considered previously as many cases remain unrecognized, especially when the children have the same sex. Here we present a pair of dizygous, sex-discordant monochorionic twins who were conceived after artificial insemination. Histological examination of the placenta and extensive genetic studies of the healthy boy and girl clearly proved that they indeed were monochorionic dizygous twins with a fully joined blood circulation. We conclude that when counseling parents expecting monochorionic twins of discordant sex, not only a disorder of sexual differentiation in one of the twins should be addressed but also the possibility of dizygosity with a completely normal (sexual) development of both children. PMID:23769301

Smeets, Dominique; van Vugt, John M G; Gomes, Ingrid; van den Heuvel, Simone; van Heijst, Arno; Reuss, Annette; Claahsen-van der Grinten, Hedi L

2013-06-17

69

Effect of borax on immune cell proliferation and sister chromatid exchange in human chromosomes  

PubMed Central

Background Borax is used as a food additive. It becomes toxic when accumulated in the body. It causes vomiting, fatigue and renal failure. Methods The heparinized blood samples from 40 healthy men were studied for the impact of borax toxicity on immune cell proliferation (lymphocyte proliferation) and sister chromatid exchange in human chromosomes. The MTT assay and Sister Chromatid Exchange (SCE) technic were used in this experiment with the borax concentrations of 0.1, 0.15, 0.2, 0.3 and 0.6 mg/ml. Results It showed that the immune cell proliferation (lymphocyte proliferation) was decreased when the concentrations of borax increased. The borax concentration of 0.6 mg/ml had the most effectiveness to the lymphocyte proliferation and had the highest cytotoxicity index (CI). The borax concentrations of 0.15, 0.2, 0.3 and 0.6 mg/ml significantly induced sister chromatid exchange in human chromosomes (P < 0.05). Conclusion Borax had effects on immune cell proliferation (lymphocyte proliferation) and induced sister chromatid exchange in human chromosomes. Toxicity of borax may lead to cellular toxicity and genetic defect in human.

Pongsavee, Malinee

2009-01-01

70

Acquired right ventricular outflow tract obstruction in the recipient twin in twin-twin transfusion syndrome  

Microsoft Academic Search

OBJECTIVESThe goal of this study was to determine the prevalence and evolution of acquired right ventricular outflow tract obstruction (RVOTO) in the recipient twin in twin-twin transfusion syndrome (TTTS).BACKGROUNDTwin-twin transfusion syndrome complicates 4% to 26% of diamniotic monochorionic twin gestations and is associated with high fetal morbidity and mortality. Cardiac dysfunction and biventricular hypertrophy may develop in the recipient twin

Jane Lougheed; Brian G. Sinclair; Karen Fung Kee Fung; Jean-Luc Bigras; Greg Ryan; Jeffrey F. Smallhorn; Lisa K. Hornberger

2001-01-01

71

Placental pathophysiology of the twin oligohydramnios-polyhydramnios sequence and the twin-twin transfusion syndrome  

Microsoft Academic Search

Currently accepted sonographic criteria for antenatal diagnosis of twin-twin transfusion (TTT) syndrome include a monochorionic placenta with same-sex twins, marked growth discordance, and oligohydramnios of the growth-retarded twin with coexistent polyhydramnios of the larger twin. Our previous report of nine women fulfilling these criteria, examined using sequential funipuncture of both fetuses, demonstrated inter-twin blood transfusion in only four cases (44

J. P. Bruner; T. L. Anderson; R. L. Rosemond

1998-01-01

72

Iatrogenic Monoamniotic Twin Gestation with Progressive Twin-Twin Transfusion Syndrome  

Microsoft Academic Search

Objective: Intentional puncture of the membrane has been reported to be a promising new method for the management of twin-twin transfusion syndrome. Case Report: Treatment of twin-twin transfusion syndrome with serial amniocenteses resulted in unintentional puncture of the dividing membrane at 24 weeks of gestation. Fetal growth discordance increased, and twin-twin transfusion did not improve following the puncture. Intrauterine death

Shunji Suzuki; Gen Ishikawa; Rintaro Sawa; Yoshio Yoneyama; Yasuo Otsubo; Tsutomu Araki

1999-01-01

73

Imaging of conjoined twins  

Microsoft Academic Search

The incidence of conjoined twins is estimated to be around 1 in 250,000 live births. There is a distinct female predominance. In this paper the imaging of conjoined twins both antenatally and postnatally is reviewed, in particular taking into consideration recent advances with multidetector CT. Accurate counselling of parents regarding the likely outcome of the pregnancy and the likelihood of

Kieran McHugh; Edward M. Kiely; Lewis Spitz

2006-01-01

74

Rotational Twin Paradox  

NASA Astrophysics Data System (ADS)

Two twins settle on a massive spherical planet at a train station S. Let's consider that each twin has an accompanying clock, and the two clocks are synchronized. One twin T1 remains in the train station, while the other twin T2 travels at a uniform high speed with the train around the planet (on the big circle of the planet) until he gets back to the same train station S. Assume the planet is not rotating. Since the planet is massive, we can consider that on a very small part on its surface the train rail road is linear, so the train is in a linear uniform motion. The larger is the planet's radius the more the rail road approaches a linear trajectory. Because the GPS clocks are alleged to be built on the Theory of Relativity, one can consider the twin T2 train's circular trajectory alike the satellite's orbit. In addition, the gravitation is the same for the reference frames of T1 and T2. Each twin sees the other twin as traveling, therefore each twin finds the other one has aged slower than him. Thus herein we have a relativistic symmetry. When T2 returns to train station S, he finds out that he is younger than T1 (therefore asymmetry). Thus, one gets a contradiction between symmetry and asymmetry.

Smarandache, Florentin

2012-10-01

75

PTX3 genetic variation and dizygotic twinning in the Gambia: could pleiotropy with innate immunity explain common dizygotic twinning in Africa?  

PubMed

Dizygotic (DZ) twinning has a genetic component and is common among sub-Saharan Africans; in The Gambia its frequency is up to 3% of live births. Variation in PTX3, encoding Pentraxin 3, a soluble pattern recognition receptor that plays an important role both in innate immunity and in female fertility, has been associated with resistance to Mycobacterium tuberculosis pulmonary disease and to Pseudomonas aeruginosa infection in cystic fibrosis patients. We tested whether PTX3 variants in Gambian women associate with DZ twinning, by genotyping five PTX3 single nucleotide polymorphisms (SNPs) in 130 sister pairs (96 full sibs and 34 half sibs) who had DZ twins. Two, three and five SNP haplotypes differed in frequency between twinning mothers and those without a history of twinning (from P = 0.006 to 3.03e-06 for two SNP and three SNP haplotypes, respectively). Twinning mothers and West African tuberculosis-controls from a previous study shared several frequent haplotypes. Most importantly, our data are consistent with an independently reported association of PTX3 and female fertility in a sample from Ghana. Taken together, these results indicate that selective pressure on PTX3 variants that affect the innate immune response to infectious agents, could also produce the observed high incidence of DZ twinning in Gambians. PMID:22834944

Sirugo, Giorgio; Edwards, Digna R Velez; Ryckman, Kelli K; Bisseye, Cyrille; White, Marquitta J; Kebbeh, Bunja; Morris, Gerard A J; Adegbola, Richard A; Tacconelli, Alessandra; Predazzi, Irene M; Novelli, Giuseppe; Vannberg, Fredrik O; Odunsi, Kunle; Page, Grier P; Williams, Scott M

2012-07-27

76

Twin-to-Twin Transfusion Syndrome: Diagnosis and Treatment  

Microsoft Academic Search

Almost all monochorionic twin pregnancies have a shared placental circulation. Twenty-five percent of these have an imbalance of blood flow leading to chronic shunting of blood from one twin to the other. Severe Twin-to-Twin Transfusion Syndrome (TTTS) develops in up to half of these pregnancies. Prenatal diagnosis relies on findings of oligo\\/anhydramnios with a decompressed bladder in the donor twin

Bettina Paek; Laurence E. Shields

2005-01-01

77

Twin Studies of Suicidal Behavior  

Microsoft Academic Search

Research on twin studies of suicidal behavior are reviewed. No Methodologically sound study on twins reared apart has et appeared, and so firm conclusions cannot be drawn from the research. Monozygotic twins reared together do appear to have higher concordance rates for suicide than dizygotic twins reared together. Confounding factors are discussed and suggestions made for future research.

David Lester

2002-01-01

78

Healthy Water, Healthy People.  

ERIC Educational Resources Information Center

Describes a hands-on activity, Hitting the Mark, which is found in the "Healthy Water, Healthy People Water Quality Educators Guide" in terms of its objectives, materials, background, procedures, activities, and assessment. (KHR)

Etgen, John

2002-01-01

79

Healthy Water, Healthy People.  

ERIC Educational Resources Information Center

|Describes a hands-on activity, Hitting the Mark, which is found in the "Healthy Water, Healthy People Water Quality Educators Guide" in terms of its objectives, materials, background, procedures, activities, and assessment. (KHR)|

Etgen, John

2002-01-01

80

Twin study on cup/disc ratio of the optic nerve head.  

PubMed Central

Seventeen healthy twin pairs (10 monozygotic and seven dizygotic) from the Finnish Twin Cohort Study were examined to study the impact of heredity v environment in the determination of cup-to-disc area ratio. These twins were free from any known eye disease. The cup/disc ratio was determined using stereo photography and a computer assisted analysis technique. The zygosity of all twin pairs was confirmed with the DNA 'fingerprint' technique. The intrapair correlations were high among monozygotic pairs compared with those among dizygotic twin pairs. The difference of cup/disc area ratios between the right eyes of members of monozygotic twin pairs was statistically significantly smaller than that of dizygotic twin pairs (p < 0.001). The same was true for left eyes (p < 0.01). This result confirms a genetic determination in cup/disc area ratio in normal eyes. Images

Teikari, J. M.; Airaksinen, J. P.

1992-01-01

81

Determinants of Plasma Levels of Plasminogen Activator Inhibitor1 A Study of Normotensive Twins  

Microsoft Academic Search

We investigated whether plasma levels of the plasminogen activator inhibitor type 1 antigen (PAI-1:Ag) are genetically determined in monozygotic (MZ) and dizygotic (DZ) twins. Twenty-five pairs of healthy twins underwent measurements of PAI-1:Ag and other variables, including body mass index, mean blood pressure, plasma renin activity, insulin, and glucose. To ascertain the zygosity of twins, highly discriminating micro- and minisatellite

Maurizio Cesari; Maria Teresa Sartori; Giovanni M. Patrassi; Silvia Vettore; Gian Paolo Rossi

82

Maternal FMR1 premutation allele expansion and contraction in fraternal twins.  

PubMed

Fragile X syndrome results from an expansion of the CGG trinucleotide repeat in the 5' untranslated region of the Fragile X Mental Retardation 1 (FMR1) gene. Expansion of a maternal premutation allele is the mechanism by which a full mutation allele arises; contraction of a maternal premutation allele is rare. Here we report on both an expansion and contraction of a maternal FMR1 premutation allele in fraternal twins. The propositus was the product of a 29-week gestation twin pregnancy and was referred for FMR1 testing due to developmental delay. A FMR1 full mutation with complete methylation was observed on Southern blot analysis. Evaluation of the maternal FMR1 gene by PCR revealed a normal and premutation allele with CGG repeat numbers of 30 and 93, respectively. Subsequent FMR1 testing on the twin sister of the propositus detected CGG repeat numbers of 30 and 54. The FMR1 CGG repeat number of the reproductive partner was 30. The FMR1 CGG repeat 30 allele in the twin sister was determined to be of paternal origin and the FMR1 allele with a CGG repeat number of 54 was of maternal origin. This observation is particularly interesting not only because of the concomitant donation of a FMR1 expanded and contracted premutation allele in a twin pregnancy but also because of the significant degree of contraction (39 repeats) of the maternal premutation allele. © 2013 Wiley Periodicals, Inc. PMID:23949867

Alfaro, Maria P; Cohen, Melinda; Vnencak-Jones, Cindy L

2013-08-15

83

Cohesins: Chromosomal Proteins that Prevent Premature Separation of Sister Chromatids  

Microsoft Academic Search

Cohesion between sister chromatids opposes the splitting force exerted by microtubules, and loss of this cohesion is responsible for the subsequent separation of sister chromatids during anaphase. We describe three chromosmal proteins that prevent premature separation of sister chromatids in yeast. Two, Smc1p and Smc3p, are members of the SMC family, which are putative ATPases with coiled-coil domains. A third

Christine Michaelis; Rafal Ciosk; Kim Nasmyth

1997-01-01

84

Sister Namibia: Fighting for all human rights for all women  

Microsoft Academic Search

Sister Namibia (sister@iafrica.com.na), a feminist women's rights organisation based in Windhoek, Namibia, was founded in 1989 on the eve of national inde- pendence to give women a voice in the building of a democratic post-colonial society. For the first ten years, the main activity of the organisation was the production of Sister Namibia magazine. From 1999 onwards, we began to

Liz Frank

85

Replication-related activities establish cohesion between sister chromatids  

Microsoft Academic Search

Replicated sister chromatids are held together from their synthesis in S phase to their separation in anaphase. The process\\u000a of sister chromatid cohesion is essential for the proper segregation of chromosomes in eukaroytic cells. Recent studies in\\u000a Saccharomyces cerevisiae have advanced our understanding of how sister chromatid cohesion is established, maintained, and dissolved during the cell\\u000a cycle. Historical observations have

Zhenghe Wang; Michael F. Christman

2001-01-01

86

[Twin studies in psychiatry].  

PubMed

Twin research in medicine and psychology has blossomed during the last decades. A brief presentation of twin research methods is given, followed by a review of psychiatric studies, particularly Norwegian ones. The Nordic investigations are of great importance because many of these studies have been able to avoid shortcomings in sampling by linking national twin registers to disease registers. This procedure is of consequence for the estimation of heritability. Twin research shows that the genetic contribution to Alzheimer's disease, manic-depressive (bipolar) disorder, schizophrenia and childhood autism is relatively strong, whereas genetic factors play a minor role in common depressions, anxiety and somatoform disorders, and alcohol abuse. Since the concordance rates are far from 100 percent in most of these illnesses, environmental factors must also be important. PMID:10533417

Kringlen, E

1999-09-20

87

Progeria in twins  

Microsoft Academic Search

A pair of male monozygotic twins, both affected by progeria is described. The concordance in this manifestation suggests a genetic aetiology and other evidence indicates the implication of autosomal recessive factors; the chromosomes of these patients show no detectable abnormalities.

Judith Viégas; P. L. R. Souza; F. M. Salzano

1974-01-01

88

Extreme Polycythemia in Recipient Twin with Twin-to-Twin Transfusion Syndrome: A Case Report  

Microsoft Academic Search

We report a case of severe polycythemia in the recipient twin of a pregnancy with twin-to-twin transfusion syndrome (TTTS). Stage I TTTS was suspected at initial presentation (24 weeks) due to discordant growth associated with a twin oligo-polyhydramnios sequence. Increasing peak systolic velocity (PSV) in the middle cerebral artery (MCA) of the donor twin indicated fetal anemia. In addition, we

Ute Braig; Wolfgang Henrich; Joachim W. Dudenhausen; Michael Obladen; Christoph Czernik

2009-01-01

89

Predicting twinning stress in fcc metals: Linking twin-energy pathways to twin nucleation  

Microsoft Academic Search

Deformation twinning is observed in numerous engineering and naturally occurring materials. However, a fundamental law for critical twinning stress has not yet emerged. We resolve this long-standing issue by integrating twin-energy pathways obtained via ab initio density functional theory with heterogeneous, dislocation-based twin nucleation models. Through a hierarchical theory, we establish an analytical expression that quantitatively predicts the critical twinning

S. Kibey; J. B. Liu; D. D. Johnson; H. Sehitoglu

2007-01-01

90

Twin relationships: A comparison across monozygotic twins, dizygotic twins, and nontwin siblings in early childhood  

Microsoft Academic Search

Twin relationships remain understudied despite the increasing prevalence of twinning and the unique influence it entails for individual development and family functioning. The current study assessed closeness, conflict, dependence, and rivalry within 1281 pairs of 3-year-old twins via maternal reports. Relationship quality was compared based on the twins' zygosity and dyadic sex-composition. As expected, monozygotic (genetically identical) twins were perceived

Keren Fortuna; Ira Goldner; Ariel Knafo

2010-01-01

91

Epigastric Heteropagus Twin  

PubMed Central

Parasitic twining is a rare type of monozygotic monochorionic monoamniotic asymmetrical conjoined twin. We report a case of epigastric heteropagus twin. An ultrasound scan showed a defect of 1.5 cm in the epigastrium. CT showed soft tissue lobulated mass with fat and air components coming out of the epigastric defect. At operation rudimentary alimentary canal with no viscera, was found in the parasite. The parasite was easily separated from the host.

Shaukat, Mahmood

2011-01-01

92

[Intact twin tubal pregnancy].  

PubMed

A case of a unilateral eight-week twin ectopic pregnancy diagnosed with transvaginal sonography is presented here. This ectopic pregnancy was found in the right Fallopian tube of a 35-year old woman. After the surgical procedure conducted by the method of transversal laparotomy, we removed the right Fallopian tube with two gestational sacs So far only a hundred of such cases of ectopic twin pregnancy have been described worldwide. PMID:21258316

Hodzic, Jasmin; Granic, Abdulah; Hodzic, Nina; Idrizbegovic, Aida

2010-08-01

93

Twin Studies of Behavior  

Microsoft Academic Search

In the age of molecular genetics some commentators have questioned whether twin studies will continue to be a useful tool\\u000a for studying genetic influences on behavior. Many of us think the answer is yes (Bouchard & Propping, 1993). Work with monozygotic\\u000a twins reared apart provides an imperfect, but nevertheless powerful window on the direct influence of genes on whole organisms.

Thomas J. Bouchard

94

Determinants of pressure pain threshold in adult twins: evidence that shared environmental influences predominate  

Microsoft Academic Search

The objective of this study was to examine the relative contribution of genetic and environmental factors in determining pain perception in a classical twin study. Dolorimeter measurements of pressure pain threshold (PPT) were recorded in 609 healthy female-female twin pairs of whom 269 pairs were monozygotic (MZ) and 340 were dizygotic (DZ). There was a strong correlation (R) in PPT

Alexander J. MacGregor; Gareth O. Griffiths; Juliet Baker; Timothy D. Spector

1997-01-01

95

Neurodevelopmental outcomes of twins.  

PubMed

In population-based studies, the prevalence of neurodevelopmental disability is consistently higher in twins than singletons. This is largely because birth weight and gestational age (GA) distributions of twin births are shifted to the left when compared with singleton births, and lower birth weight and lower GA are associated with increased risk of neurodevelopmental disability. From a pathophysiologic perspective, a question of interest is whether neurodevelopmental outcomes of twins differ from singletons after controlling for covariates. If significant differences in outcomes persist, this would suggest that the twining process itself or something intrinsic to shared life in the womb may be responsible for observed differences. From a clinical perspective, when counseling parents at risk for preterm delivery of twins, it is useful to understand how twin outcomes compare relative to singleton outcomes at the same birth weight or GA. The purpose of this review is to examine the long-term neurodevelopmental outcomes of twins compared with singletons with control for important covariates. PMID:22713502

Lorenz, John M

2012-06-01

96

A comprehensive neuropsychiatric study of elderly twins: the Older Australian Twins Study.  

PubMed

The Older Australian Twins Study (OATS) was recently initiated to investigate genetic and environmental factors and their associations and interactions in healthy brain ageing and ageing-related neurocognitive disorders. The study extends the classic MZ-DZ design to include one or two equivalently aged siblings for each twin pair and utilizes the rich resources of the Australian Twin Registry. The study has a number of distinguishing features including comprehensive psychiatric, neuropsychological, cardiovascular, metabolic, and neuroimaging assessments, a longitudinal design and links with a brain donor program. The study measures many behavioral and environmental factors, but in particular lifetime physical and mental activity, physical and psychological trauma, loss of parent early in life, later losses and life events, early-life socioeconomic environment, alcohol and drug use, occupational exposure, and nutrition. It also includes comprehensive cardiovascular assessment, blood biochemistry, genetics and proteomics. The socio-demographic and health data on the first 172 pairs of twins participating in this study are presented. Prevalence of mild cognitive impairment is 12.8% and of dementia 1.5% in the sample. The target sample size is 1000, with at least 400 pairs of twins aged 65-90 years. The cohort will be assessed every two years, with in-depth assessments being repeated. OATS offers an excellent opportunity for collaboration with other similar studies as well as researchers who share the same interests. PMID:19943720

Sachdev, Perminder S; Lammel, Andrea; Trollor, Julian N; Lee, Teresa; Wright, Margaret J; Ames, David; Wen, Wei; Martin, Nicholas G; Brodaty, Henry; Schofield, Peter R

2009-12-01

97

Twins: A cloning experience.  

PubMed

Drawing upon qualitative interviews with monozygotic (identical) twins sharing 100% of their genes, and with dizygotic (fraternal) twins and singletons as control groups, this paper explores what it means to be genetically identical. (The twins interviewed were from the TwinsUK register in London.) In the context of the ongoing debate on human reproductive cloning, it examines questions such as: To what extent do identical twins perceive their emotional and physical bond to be a result of their genetic makeup? What would they think if they had been deliberately created genetically identical? How would they feel about being genetically identical to a person who was born a few years earlier or later? First, our respondents ascribed no great significance to the role of genes in their understanding of what it means to be identical twins. Second, the opinion that human reproductive cloning would "interfere with nature", or "contradict God's will", was expressed by our respondents exclusively on the abstract level. The more our respondents were able to relate a particular invented cloning scenario to their own life-worlds, the lower the prevalence of the argument. Third, for all three groups of respondents, the scenario of having been born in one of the other groups was perceived as strange. Fourth, the aspect that our respondents disliked about cloning scenarios was the potential motives of the cloners. Without equating monozygotic twins directly with "clones", these results from "naturally" genetically identical individuals add a new dimension to what a future cloning situation could entail: The cloned person might possibly (a) perceive a close physical and emotional connection to the progenitor as a blessing; (b) suffer from preconceptions of people who regard physical likeness as a sign of incomplete individuality; and (c) perceive the idea of not having been born a clone of a particular person as unpleasant. PMID:16876924

Prainsack, Barbara; Spector, Tim D

2006-07-31

98

Gestational age in twins.  

PubMed Central

Dubowitz et al. have offered a scoring system for estimating the gestational age of newborn babies. If the system is applied to twin pairs, the heavier twin is generally estimated to have a greater gestational age than the lighter one. Previously this has been interpreted as a flaw in the scoring system. However, it may well be that in some twin pairs the gestational ages are slightly different and that therefore, the heavier twin would be expected to have a greater gestational age. Such cases would arise through superfecundation (the formation of two zygotes from different coitions). Superfecundation can be proved only in rare case (those with two fathers). It can be argued that the rarity of such cases is accounted for by the rarity with which women expose themselves to the risk of bearing such twins (and by the improbability of detection), rather than by the rarity of superfecundation. It is inferred that superfecundation by the same man is relatively common and that therefore dizygotic twins quite often have different gestational ages. The scoring system of Dubowitz can be tested for bias by submitting monozygotic pairs to it: the association between weight and estimated gestational age should be absent in such pairs. If the system proves free of such bias, then a finding first reported here will assume some interest: it is that in opposite-sexed twin pairs, the male is significantly more often assessed as having the greater gestational age. It is suggested that this finding should be provisionally accepted as evidence for the hyopthesis that male zygotes are formed earlier than females.

James, W H

1980-01-01

99

Serial MR imaging and 1H-MR spectroscopy in monozygotic twins with Tay-Sachs disease.  

PubMed

Four-year-old monozygotic female twins with early onset Tay-Sachs disease are described. The sisters showed similar slowly progressive clinical symptoms and deterioration, however the younger sister also demonstrated intractable myoclonus in the right leg. The serial MR images and (1)H-MR spectroscopy of the brain were obtained in both twins. MR images showed high intensity on T (2)-weighted image in the bilateral white matter, however there were no signal changes in the basal ganglia and thalamus during any of the phases. The ratio of N-acetylaspartate (NAA)/creatine (Cr) was decreased in the both white matter lesions and the corpus striatum, and that of myoinositol (mI)/Cr was increased in the damaged white matter on MR spectroscopy. The elevation of the lactate peak was clearly demonstrated in the left basal ganglia of the younger sister; however it was not shown in cerebral lesions of the elder sister. Changes in metabolites on MR spectroscopy were closely linked to the respective clinical features of each twin. Follow-up examination by (1)H-MR spectroscopy is useful for the evaluation of neuronal changes in children with Tay-Sachs disease. PMID:19294598

Imamura, A; Miyajima, H; Ito, R; Orii, K O

2009-03-17

100

Pericentromeric sister chromatid cohesion promotes kinetochore biorientation.  

PubMed

Accurate chromosome segregation depends on sister kinetochores making bioriented attachments to microtubules from opposite poles. An essential regulator of biorientation is the Ipl1/Aurora B protein kinase that destabilizes improper microtubule-kinetochore attachments. To identify additional biorientation pathways, we performed a systematic genetic analysis between the ipl1-321 allele and all nonessential budding yeast genes. One of the mutants, mcm21Delta, precociously separates pericentromeres and this is associated with a defect in the binding of the Scc2 cohesin-loading factor at the centromere. Strikingly, Mcm21 becomes essential for biorientation when Ipl1 function is reduced, and this appears to be related to its role in pericentromeric cohesion. When pericentromeres are artificially tethered, Mcm21 is no longer needed for biorientation despite decreased Ipl1 activity. Taken together, these data reveal a specific role for pericentromeric linkage in ensuring kinetochore biorientation. PMID:19605555

Ng, Tessie M; Waples, William G; Lavoie, Brigitte D; Biggins, Sue

2009-07-15

101

Pericentromeric Sister Chromatid Cohesion Promotes Kinetochore Biorientation  

PubMed Central

Accurate chromosome segregation depends on sister kinetochores making bioriented attachments to microtubules from opposite poles. An essential regulator of biorientation is the Ipl1/Aurora B protein kinase that destabilizes improper microtubule–kinetochore attachments. To identify additional biorientation pathways, we performed a systematic genetic analysis between the ipl1-321 allele and all nonessential budding yeast genes. One of the mutants, mcm21?, precociously separates pericentromeres and this is associated with a defect in the binding of the Scc2 cohesin-loading factor at the centromere. Strikingly, Mcm21 becomes essential for biorientation when Ipl1 function is reduced, and this appears to be related to its role in pericentromeric cohesion. When pericentromeres are artificially tethered, Mcm21 is no longer needed for biorientation despite decreased Ipl1 activity. Taken together, these data reveal a specific role for pericentromeric linkage in ensuring kinetochore biorientation.

Ng, Tessie M.; Waples, William G.; Lavoie, Brigitte D.

2009-01-01

102

Mouse satellite DNA, centromere structure, and sister chromatid pairing  

Microsoft Academic Search

The experiments described were directed toward understanding relationships between mouse satellite DNA, sister chromatid pairing, and centromere function. Electron microscopy of a large mouse L929 marker chromosome shows that each of its multiple constrictions is coincident with a site of sister chromatid contact and the presence of mouse satellite DNA. However, only one of these sites, the central one, possesses

Lorraine M. Lica; Sandya Narayanswami; Barbara A. Hamkalo

1986-01-01

103

Andromeda and the Milky Way: Twin sisters, distant relations, or strangers in the night?  

NASA Astrophysics Data System (ADS)

I summarize some recent key results from the Pan-Andromeda Archaeological Survey (PAndAS), in particular showing how recent discoveries in and around M31 compare to the known structure of the Milky Way and its satellite population.

McConnachie, A.; Richardson, J.; Mackey, D.

2012-02-01

104

IVF for premature ovarian failure: first reported births using oocytes donated from a twin sister  

Microsoft Academic Search

BACKGROUND: Premature ovarian failure (POF) remains a clinically challenging entity because in vitro fertilisation (IVF) with donor oocytes is currently the only treatment known to be effective. METHODS: A 33 year-old nulligravid patient with a normal karyotype was diagnosed with POF; she had a history of failed fertility treatments and had an elevated serum FSH (42 mIU\\/ml). Oocytes donated by

Eric Scott Sills; Adam C Brady; Ahmed B Omar; David J Walsh; Umme Salma; Anthony PH Walsh

2010-01-01

105

Cervix smear abnormalities: linking pathology data in female twins, their mothers and sisters  

Microsoft Academic Search

Mass screening for cervical cancer precursors has decreased the incidence of cervical cancer in several countries, including the Netherlands. Persistent infections of certain types of human papillomavirus are strongly associated with the development of cervical cancer. A number of factors may affect the liability to infection and subsequent progression to cervical intraepithelial neoplasia and cancer. This paper examines whether genetic

Jacqueline M Vink; Folkert J van Kemenade; Chris J L M Meijer; Mariel K Casparie; Gerrit A Meijer; Dorret I Boomsma

2011-01-01

106

Cohesin's Concatenation of Sister DNAs Maintains Their Intertwining  

PubMed Central

Summary The contribution of DNA catenation to sister chromatid cohesion is unclear partly because it has never been observed directly within mitotic chromosomes. Differential sedimentation-velocity and gel electrophoresis reveal that sisters of 26 kb circular minichromosomes are held together by catenation as well as by cohesin. The finding that chemical crosslinking of cohesin's three subunit interfaces entraps sister DNAs of circular but not linear minichromosomes implies that cohesin functions using a topological principle. Importantly, cohesin holds both catenated and uncatenated DNAs together in this manner. In the vicinity of centromeres, catenanes are resolved by spindle forces, but linkages mediated directly by cohesin resist these forces even after complete decatenation. Crucially, persistence of catenation after S phase depends on cohesin. We conclude that by retarding Topo II-driven decatenation, cohesin mediates sister chromatid cohesion by an indirect mechanism as well as one involving entrapment of sister DNAs inside its tripartite ring.

Farcas, Ana-Maria; Uluocak, Pelin; Helmhart, Wolfgang; Nasmyth, Kim

2011-01-01

107

The Texas Twin Project  

PubMed Central

Socioeconomic position, racial/ethnic minority status, and other characteristics of the macro-environment may be important moderators of genetic influence on a wide array of psychosocial outcomes. Designed to maximize representation of low socioeconomic status families and racial/ethnic minorities, the Texas Twin Project is an on-going study of school-age twins (preschool through 12th grade) enrolled in public schools in the Austin, Texas and Houston, Texas metropolitan areas. School rosters are used to identify twin families from a target population with sizable populations of African-American (18%), Hispanic / Latino (48%), and non-Hispanic White (27%) children and adolescents, over half of whom meet U.S. guidelines for classification as economically disadvantaged. Initial efforts have focused on a large-scale, family-based survey study involving both parent and child reports of personality, psychopathology, physical health, academic interests, parent-child relationships, and aspects of the home environment. In addition, the Texas Twin Project is the basis for an in-laboratory study of adolescent decision-making, delinquency, and substance use. Future directions include geographic expansion of the sample to the entire state of Texas (with a population of over 25 million people) and genotyping of participating twins.

Harden, K. Paige; Tucker-Drob, Elliot M.; Tackett, Jennifer L.

2013-01-01

108

Implications of twin research for legal issues involving young twins  

Microsoft Academic Search

Twin studies have generated numerous findings that have had substantial impact upon research conducted in psychological and medical science disciplines. Twin research has, however, been underutilized utilized as an information base relevant to decision making in the legal domain. Current empirical knowledge of twins and the various legal issues for which they offer implications are reviewed. Selected case studies of

Nancy L. Segal

1993-01-01

109

Branching of twins near an austenite - twinned-martensite interface  

Microsoft Academic Search

We study the role of surface energy in determining twin width near an austenite—twinned-martensite interface. We find that there are two distinct regimes, depending on the relative values of the elastic moduli, surface energy density and grain size. In the first regime the twin width w is constant, of order L , where L is the grain size. In the

Robert V. Kohn; Stefan Müller

1992-01-01

110

Lenticulostriate vasculopathy in twin-to-twin transfusion syndrome  

Microsoft Academic Search

Intracranial pathology is a common and important complication in extremely low birth weight babies. Lenticulostriate vasculopathy (LSV) is an abnormal finding on cranial ultrasounds of sick babies and has been associated with congenital infection, chromosomal aberration and twin-to-twin transfusion. We describe a previously unreported situation of LSV being detected in both donor and recipient twin. This pair of monochorionic, diamniotic

Y Kandasamy; G Alcock; T H H G Koh; zDr Y Kandasamy

2006-01-01

111

20 CFR 725.222 - Conditions of entitlement; parent, brother, or sister.  

Code of Federal Regulations, 2013 CFR

... false Conditions of entitlement; parent, brother, or sister. 725.222 ...725.222 Conditions of entitlement; parent, brother, or sister. (a) An individual...is eligible for benefits as a surviving parent, brother or sister if all of the...

2013-04-01

112

20 CFR 725.225 - Determination of dependency; parent, brother, or sister.  

Code of Federal Regulations, 2013 CFR

... false Determination of dependency; parent, brother, or sister. 725.225 ...225 Determination of dependency; parent, brother, or sister. An individual who is the miner's parent, brother, or sister will be...

2013-04-01

113

Lessons from monochorionic twin delivery  

PubMed Central

The presence of acute peripartum anaemia in a monochorionic twin pregnancy represents a clinical challenge requiring prompt recognition and management. Twin-to-twin transfusion syndrome (TTTS) is a major complication of these pregnancies and a medical emergency in its acute form. Acute intrapartum fetoplacental transfusion (AIFT) has been reported infrequently. The authors present a case of a probable acute TTTS in an uneventful monochorionic monoamnionic twin pregnancy, where typical ultrasound criteria for long-standing TTTS were absent. The first twin was born pale, hypotonic and developed hypovolemic shock due to acute anaemia. Soon after birth, she presented with seizures and a cerebral ultrasound detected a large parieto-occipital infarction. The second twin, although plethoric, was clinically well. The risk of acute TTTS and AIFT, although infrequent and unpredictable, should be kept in mind when planning delivery of monochorionic twins, because the consequences for one or both twins can be disastrous.

Ferreira, Sofia Almeida; Januario, Gustavo Machado Guimaraes; Pereira, Dolores Faria; Silva, Isabel Santos; Negrao, Fatima

2011-01-01

114

Fraternal twins with Morgagni hernias  

Microsoft Academic Search

Fraternal twins with identical left-sided foramen of Morgagni hernias are described. The occurrence of this rare type of congenital diaphragmatic hernia in twins suggests that genetic factors play a role in the formation of this lesion.

Stanley T. Lau; Stephen S. Kim; Daniel J. Ledbetter; Patrick J. Healey

2005-01-01

115

Allergic colitis in monozygotic preterm twins.  

PubMed

Allergic colitis (AC) typically develops in the first weeks or months of life and is characterized by the presence of red blood in the stools of healthy breastfed or formula fed infants. In this paper, we describe a case of rectal bleeding in monozygotic preterm twins that was resolved with the introduction of a cow's milk protein-free diet (CMPFD). The occurrence of this disorder in monozygotic twins raises the question as to whether the underlying abnormality in the immune regulation, which leads to poor acquisition of tolerance to cow's milk proteins, might be inherited or environmentally acquired. The case also highlights the use of the probiotic Lactobacillus GG (LGG) in the treatment of allergic colitis. PMID:23098248

Baldassarre, Maria Elisabetta; Cappiello, Annarita; Laforgia, Nicola; Vanderhoof, Jon

2012-10-26

116

Monochorionic monoamniotic twins: neonatal outcome  

Microsoft Academic Search

Background:Monochorionic monoamniotic twins (MoMo) occur in one of 10 000 pregnancies. Cord entanglement, malformations, twin-to-twin transfusion syndrome (TTS) and prematurity are responsible for their high perinatal morbidity and mortality.Objective:To report our experience with 36 sets of MoMo twins (1990 to 2005) and to provide updated information for counseling.Methods:Chorionicity was determined by placental examination, gestational age and TTS clinically and by

L Cordero; A Franco; S D Joy

2006-01-01

117

Twins in Cardiovascular Genetic Research  

Microsoft Academic Search

Abstract—Twin studies have been largely responsible for showing,the effects of genetic variance on a quantitative trait. The model is based on the fact that monozygotic twins share all genes in common, whereas dizygotic twins are related as siblings and share “on average” half their genes. Environmental confounders,are minimized,because twin children are usually exposed to similar environments. Blood pressure was first

Friedrich C. Luft

2010-01-01

118

Discriminability of Fingerprints of Twins  

Microsoft Academic Search

Abstract. A study of the discriminability of fingerprints of twins on a significant data set is presented. The twin study reported is based on fingerprints of 297 pairs of twins. The data used in the study is of high quality and quantity due to: (i) young population considered, (ii) fingerprints were obtained using a live scan device, and (iii) there

Sargur N. Srihari; Harish Srinivasan; Gang Fang; Arvindakshan Ravichandran

119

A Multidimensional Twin Study of Mental Health in Women  

Microsoft Academic Search

Objective: While researchers have increasing insight into the role of genetic and envi- ronmental factors in the etiology of psychiatric and substance use disorders, they know much less about how such factors influence the dimensions of healthy psychological functioning. Method: In a population-based sample of 794 female-female twin pairs, the authors examined, by using multivariate structural equation modeling, six dimensions

Kenneth S. Kendler; John M. Myers; Michael C. Neale

2000-01-01

120

A Case Study of Recipient Twin Surviving Complications of Twin-to-Twin Transfusion Syndrome.  

PubMed

Twin-to-twin transfusion syndrome (TTTS) has a high rate of mortality and morbidity. This article describes the clinical course of a recipient twin in a case of TTTS. The twin was on long-term respiration support and survived two resuscitations, pneumothorax, chest tube placement, blood exchange, necrotizing enterocolitis and corrective surgery. This case demonstrates that the effective use of a collaborative, multidisciplinary care approach between two hospitals can result in a newborn surviving a severe case of TTTS. PMID:24138658

Squires, Linda Sharee

2013-10-01

121

Education Issues; Twin Study Summaries; Famous Twin Babies and Famous Twins  

Microsoft Academic Search

wo educational issues of special relevance to twins and their families are reviewed. The first concerns newly passed legislation in the state of Minnesota allowing multiple birth parents to decide if their children should be placed in the same or separate classrooms. The second concerns a professor's accusations of identical twins' academic misconduct, based upon the twins' similar test performance.

Nancy L Segal

2005-01-01

122

Twin-Spot MARCM to reveal developmental origin and identity of neurons  

PubMed Central

A comprehensive understanding of the brain requires analysis of individual neurons. Here we describe twin-spot MARCM for high-resolution lineage tracing by independent labeling of paired sister clones. We determine patterns of neurogenesis and the influences of lineage on neuron-type specification. Notably, neural progenitors may yield intermediate precursors that make one, two, or more neurons. Furthermore, neurons acquire stereotyped projections according to their temporal position within various brain sublineages. Twin-spot MARCM also permits birth dating of mutant clones, enabling the detection of a single temporal fate that requires chinmo in a sublineage of six Drosophila central complex neurons. In sum, twin-spot MARCM can reveal the developmental origins of neurons and the mechanisms that underlie cell fate.

Yu, Hung-Hsiang; Chen, Chun-Hong; Shi, Lei; Huang, Yaling; Lee, Tzumin

2009-01-01

123

Uncomplicated monochorionic diamniotic twin pregnancy.  

PubMed

There have been significant advances in our understanding of the aetiology and management of disorders specific to Monochorionic Diamniotic (MCDA) twin pregnancies like Twin-Twin Transfusion Syndrome (TTTS) and Twin Reversed Arterial Perfusion (TRAP) but there is paucity of data about the management of uncomplicated MCDA twins pregnancies. It is accepted that even in the absence of specific complications, these pregnancies are associated with increased perinatal morbidity & mortality. The aim of this review is to gather evidence regarding the management of seemingly uncomplicated monochorionic diamniotic pregnancies. PMID:19274536

Nair, M; Kumar, G

2009-02-01

124

Breast cancer after Hodgkin's disease in two sisters  

SciTech Connect

Two sisters had breast cancer at four years and 11 years after diagnosis of Hodgkin's disease. The affected breast tissues had received several hundred rads of scatter radiation during treatment of the lymphoma. Family history revealed breast cancer in a third sister and five other women in the paternal line. Cytogenetic and HLA studies showed no markers of susceptibility to neoplasia. Development of second primary neoplasms of the breast in the two sisters may have resulted from interactions between genetic factors and carcinogenic effects of radiation exposure.

Li, F.P.; Corkery, J.; Canellos, G.; Neitlich, H.W.

1981-01-01

125

Anorexia nervosa in Twins  

Microsoft Academic Search

In 1979, Askevold and Heiberg made an interesting contribution to the discussion on the hereditability of anorexia nervosa by reviewing a series of case reports concerning monozygotic twins. Their data, however, were not entirely accurate and they also overlooked some important references which are briefly discussed. 3 cases of the authors’ own practice are added. A final examination of the

W. Vandereycken; R. Pierloot

1981-01-01

126

Overripe ova and twinning.  

PubMed Central

Multiple births were studied in a sample of orthodox Jewesses for whom an estimate could be made of the day of ovulation and the earliest possible day of conception. The overall rate of twinning was 14.5/1,000 deliveries, and of triplets, 0.40/1,000. Twinning rates varied significantly from 11.4 in the 5,976 "early" conceptions (day -1 or earlier relative to the estimated day of ovulation) to 26.9 in the 1,498 "late" conceptions (day 0 or later). Triplets varied significantly from 0 to 2.01 in early and late conceptions, respectively, and unlike-sexed multiple sets, 2.8 and 12.8, respectively. The excess of multiple births in late conceptions was seen within different ages and origin groups, in women with different menstrual characteristics, and in those with and without treatment for anovulation. While the excess of unlike-sexed sets seems to lead to the conclusion that late conceptions are associated with dizygosity, polar body twinning and uniovular dispermatic twinning should also be considered.

Harlap, S; Shahar, S; Baras, M

1985-01-01

127

Twin Towers of Hanoi  

Microsoft Academic Search

In the Twin Towers of Hanoi version of the well known Towers of Hanoi Problem there are two coupled sets of pegs. In each move, one chooses a pair of pegs in one of the sets and performs the only possible legal transfer of a disk between the chosen pegs (the smallest disk from one of the pegs is moved

Zoran Sunic

2011-01-01

128

Intrauterine growth of twins  

Microsoft Academic Search

In a retrospective study of 150 twins born between 1970–1977, birth weight, length, and head circumference was plotted against gestational age. In comparison to singletons, all 3 parameters were low normal. While length and head circumference values follow the growth pattern of singletons, prenatal birth weight shows a progressive decline toward maturity.

A. Fenner; T. Malm; U. Kusserow

1980-01-01

129

Tetartohedral twinning could happen to you too  

PubMed Central

Tetartohedral crystal twinning is discussed as a particular case of (pseudo)merohedral twinning when the number of twinned domains is four. Tetartohedrally twinned crystals often possess pseudosymmetry, with the rotational part of the pseudo­symmetry operators coinciding with the twinning operators. Tetartohedrally twinned structures from the literature are reviewed and the recent structure determination of tetartohedrally twinned triclinic crystals of human complement factor I is discussed.

Roversi, Pietro; Blanc, Eric; Johnson, Steven; Lea, Susan Mary

2012-01-01

130

International Cooperation for Vocational Rehabilitation Through the Sister City Program.  

National Technical Information Service (NTIS)

A demonstration project to establish working relationships between American groups interested in the handicapped and similar groups in other countries found that there are numerous ways in which the handicapped can be helped through the existing Sister Ci...

1971-01-01

131

8. STREAMSIDE PATH NEAR MIDDLE OF THREE SISTERS FALLS, LOOKING ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

8. STREAM-SIDE PATH NEAR MIDDLE OF THREE SISTERS FALLS, LOOKING WEST Photocopy of photograph, 1930s National Park Service, National Capital Region files - Dumbarton Oaks Park, Thirty-second & R Streets Northwest, Washington, District of Columbia, DC

132

14. UPPER THREE SISTERS FALLS, LOOKING NORTHWEST Photocopy of photograph, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

14. UPPER THREE SISTERS FALLS, LOOKING NORTHWEST Photocopy of photograph, 1930s National Park Service, National Capital Region files - Dumbarton Oaks Park, Thirty-second & R Streets Northwest, Washington, District of Columbia, DC

133

Placental Regulation of Insulin-Like Growth Factor Axis in Monochorionic Twins with Chronic Twin-Twin Transfusion Syndrome  

Microsoft Academic Search

To test the hypothesis that severe growth restriction (intrauterine growth retardation) in donor twins with chronic twin-twin transfu- sion syndrome (TTTS), a common complication of monochorionic twin pregnancy, is due to an aberration in the insulin-like growth factor (IGF) axis, we studied 25 sets of monochorionic twins with (n 5 13) and without (n 5 12) TTTS. Maternal and cord

REKHA BAJORIA; MARTIN J. GIBSON; STUART WARD; SUREN R. SOORANNA; JAMES P. NEILSON; MELISSA WESTWOOD

134

A Case of Amyoplasia in a Monochorionic Twin Pregnancy: A Sequela from Twin-Twin Transfusion Syndrome?  

Microsoft Academic Search

Objective: To present and discuss the sonographic and clinical findings in one twin of a monochorionic pair affected by amyoplasia. Methods: On ultrasound examination at 21 weeks in a monochorionic twin pregnancy, twin I was smaller, hydropic, with multiple contractures consistent with amyoplasia and oligohydramnios. Twin II was anatomically normal with polyhydramnios. Results: The twins were delivered at 28 weeks’

H. S. Wong; A. Kidd; J. Zuccollo; S. Parker; V. Richardson; J. Tait; K. C. Pringle

2009-01-01

135

Mechanism of differential Giemsa method for sister chromatids  

Microsoft Academic Search

THE 33258 Hoechst fluorescence1 and 33258 Hoechst-Giemsa2 methods for differential staining of bromodeoxy-uridine (BrdU)-incorporated chromatids are attractive because of their rapidity and high sensitivity in revealing small sister chromatid exchanges which escape detection by autoradiography. Since carcinogen-induced chromatid breaks are associated with sister chromatid exchanges3 and breakage formation parallels carcinogenesis in typical cases4,5, these methods are essential for understanding the

Taketoshi Sugiyama; Keiko Goto; Yoshio Kano

1976-01-01

136

Sister chromatid resolution: a cohesin releasing network and beyond  

Microsoft Academic Search

When chromosomes start to assemble in mitotic prophase, duplicated chromatids are not discernible within each chromosome.\\u000a As condensation proceeds, they gradually show up, culminating in two rod-shaped structures apposed along their entire length\\u000a within a metaphase chromosome. This process, known as sister chromatid resolution, is thought to be a prerequisite for rapid\\u000a and synchronous separation of sister chromatids in anaphase.

Keishi Shintomi; Tatsuya Hirano

2010-01-01

137

Cohesion between sister chromatids must be established during DNA replication  

Microsoft Academic Search

Background: Cohesion between sister chromatids, which opposes the splitting force exerted by the mitotic spindle during metaphase, is essential for their segregation to opposite poles of the cell during anaphase. In Saccharomyces cerevisiae, cohesion depends on a set of chromosomal proteins called cohesins, which include structural maintenance of chromosomes 1p (Smc1p), Smc3p and sister chromatid cohesion 1p (Scc1p). Strains with

Frank Uhlmann; Kim Nasmyth

1998-01-01

138

Efficiency of working memory encoding in twins discordant for schizophrenia  

PubMed Central

It has been proposed that patients with schizophrenia and some of their relatives suffer from reduced neurocognitive efficiency, increasing their sensitivity to experimental task demands. The present study evaluated such a possibility during performance of a working memory task by schizophrenia patients and their co-twins along with a healthy control sample. Electrophysiological data were obtained from sets of 9 twin pairs (monozygotic and dizygotic pairs collapsed) discordant for a diagnosis of schizophrenia and from 9 matched, healthy control twin pairs, during administration of a variable-load spatial working memory task. Event-related potentials (ERPs) were measured immediately after memory set onset and during a delay period. For correctly performed trials, slow-wave ERP activity measured during the late stimulus encoding and delay periods exhibited a significant Diagnostic Group-by-Memory Load interaction, with schizophrenia patients showing a differentially strong load effect. Patients’ co-twins displayed an intermediate level of load sensitivity while healthy controls showed no significant load effect. These results support an inefficiency model of neurocognitive dysfunction in schizophrenia, a pattern that appears to be related to the pathogenesis and inheritance of the disorder. Furthermore, this inefficiency appeared during the late stimulus encoding stage of working memory functioning, possibly reflecting disruptions in stimulus representation consolidation.

Bachman, Peter; Kim, Junghoon; Yee, Cindy M.; Therman, Sebastian; Manninen, Marko; Lonnqvist, Jouko; Kaprio, Jaakko; Huttunen, Matti O.; Naatanen, Risto; Cannon, Tyrone D.

2009-01-01

139

Molecular analysis of sister chromatid recombination in mammalian cells  

PubMed Central

Sister chromatid recombination (SCR) is a potentially error-free pathway for the repair of double-strand breaks arising during replication and is thought to be important for the prevention of genomic instability and cancer. Analysis of sister chromatid recombination at a molecular level has been limited by the difficulty of selecting specifically for these events. To overcome this, we have developed a novel “nested intron” reporter that allows the positive selection in mammalian cells of “long tract” gene conversion events arising between sister chromatids. We show that these events arise spontaneously in cycling cells and are strongly induced by a site-specific double-strand break (DSB) caused by the restriction endonuclease, I-SceI. Notably, some I-SceI-induced sister chromatid recombination events entailed multiple rounds of gene amplification within the reporter, with the generation of a concatemer of amplified gene segments. Thus, there is an intimate relationship between sister chromatid recombination control and certain types of gene amplification. Dysregulated sister chromatid recombination may contribute to cancer progression, in part, by promoting gene amplification.

Puget, Nadine; Knowlton, Melodie; Scully, Ralph

2010-01-01

140

Twin-to-twin transfusion syndrome: a case study.  

PubMed

Twin-to-twin transfusion syndrome (TTTS) is a disease that affects roughly 15% of monochorionic twins. Although TTTS is not extremely prevalent, the rate of mortality and morbidly approaches 100% without early detection and treatment. The following case study is a triplet pregnancy that included a set of monochorionic twins affected by TTTS. Typically, it is assumed that monochorionicity can identify the zygosity of twins, which was disproven in this case. Research indicates that there has been an increased rate of monochorionic twins with in vitro fertilization. There is great debate about the most appropriate treatment modality for TTTS. Perinatal treatment followed by neonatal management is the standard of care for TTTS. Implications for the neonatal nurse practitioner and care for the patients are discussed. PMID:23360857

Giconi, Stephanie S

2013-02-01

141

Status of Twin Research in Functional Psychoses  

Microsoft Academic Search

After briefly reviewing the main findings of twin research in. functional psychoses, the author focuses the attention on neglected aspects of twin research, such as the study of co-twins of monozygotic (MZ) subjects with functional psychosis, and the study of life histories of discordantly affected twins. Through a thorough investigation of the nonpsychotic co-twins of MZ subjects, one might be

Einar Kringlen

1986-01-01

142

Twin-singleton differences in intelligence?  

Microsoft Academic Search

The twin method has been criticised for its alleged non-generalisability. When population parameters of intellectual abilities are estimated from a twin sample, critics point to the twin- singleton differences in intrauterine and family environments. These differences are suggested to lead to suboptimal cognitive development in twins. Although previous studies have reported twin- singleton differences in intelligence, these studies had two

Daniëlle Posthuma; Geus de E. J. C; Nico Bleichrodt; Dorret I Boomsma

2000-01-01

143

Clinical consequences of twin-to-twin transfusion  

Microsoft Academic Search

Twin-to-twin transfusion (TTT) is a complication of monochorionic twins that may result in high mortality and morbidity. To better understand pathophysiology in TTT and the consequences for affected fetuses and neonates, we describe the clinical features of 19 consecutive pregnancies complicated by TTT over 5 years. The diagnosis was made based on the findings of polyhydramnios-oligohydramnios sequence with weight discordance

Ming-Chou Chiang; Reyin Lien; An-Shine Chao; Yi-Hung Chou; Yu-Jen en Chen

2003-01-01

144

Acardiac twin pregnancy with neonatal resolution of donor twin cardiomyopathy  

Microsoft Academic Search

Background: Twin reverse arterial perfusion, as with acardiac fetuses, is a rare complication of multifetal pregnancy. Prognosis of the donor twin is guarded because of the high risk of cardiac failure, polyhydramnios, and preterm delivery.Case: A 40-year-old woman, gravida 4, para 3, was diagnosed at 19 weeks’ gestation with a twin pregnancy complicated by an acardiac, acephalic fetus. Serial amniocenteses

Sujata Chandra; Joan M. G. Crane; David C. Young; Surya Shah

2000-01-01

145

Increasing cardiac output and decreasing oxygenation sequence in pump twins of acardiac twin pregnancies  

Microsoft Academic Search

An acardiac twin pregnancy is a rare but serious complication of monochorionic twinning and consists of an acardiac twin and a pump twin. The acardiac twin is a severely malformed fetus that lacks most organs, particularly a heart, but grows during pregnancy because it is perfused by the developmentally normal pump twin via a set of arterioarterial and venovenous placental

Martin J C van Gemert; Asli Umur; Jeroen P H M van den Wijngaard; Ed VanBavel; Frank P H A Vandenbussche; Peter G J Nikkels

2005-01-01

146

NOTE: Increasing cardiac output and decreasing oxygenation sequence in pump twins of acardiac twin pregnancies  

Microsoft Academic Search

An acardiac twin pregnancy is a rare but serious complication of monochorionic twinning and consists of an acardiac twin and a pump twin. The acardiac twin is a severely malformed fetus that lacks most organs, particularly a heart, but grows during pregnancy because it is perfused by the developmentally normal pump twin via a set of arterioarterial and venovenous placental

Martin J. C. van Gemert; Asli Umur; Jeroen P. H. M. van den Wijngaard; Ed Van Bavel; Frank P. H. A. Vandenbussche; Peter G. J. Nikkels

2005-01-01

147

NOVA: Separating Twins  

NSDL National Science Digital Library

How do skilled surgeons go about crafting a surgical procedure that will separate twins? That was the challenge faced by those medical experts who prepared to separate Trishna and Krishna, twin girls joined at the head who had been abandoned at an orphanage in Bangladesh. Visitors can watch the entire NOVA program that profiles this most remarkable procedure, and it's a great way to learn about this tremendously complex process. After watching the film, visitors can look over the Related Links. Here they can read an interview with one of the main surgeons, watch a short video on brain trauma, and find out about the possible future of brain transplants. On the right-hand side of the page, visitors can view related multimedia features, such as a map of the human heart.

2012-03-16

148

The embryology of conjoined twins  

Microsoft Academic Search

IntroductionAttention is drawn to the spontaneous incidence of twinning, both dizygotic and monozygotic in different mammalian species. Conjoined twinning, however, only arises when the twinning event occurs at about the primitive streak stage of development, at about 13–14 days after fertilisation in the human, and is exclusively associated with the monoamniotic monochorionic type of placentation. It is believed that the highest

M. H. Kaufman

2004-01-01

149

Birthweight and adult health in a population-based sample of Norwegian twins.  

PubMed

Population-based twin data were used to test (a) whether lower birthweight confers a greater risk of adult health disorders, and (b) whether within-pair birthweight differences in twins explain discordance for health outcomes. The sample consisted of 1201 monozygotic (MZ) male twins, 1048 dizygotic (DZ) male twins, 1679 MZ female twins, 1489 DZ female twins, and 2423 opposite-sex DZ twins, born in Norway between 1967 and 1979. The relationship between birthweight and self-reported health outcomes were studied using multivariable logistic regression. In the full sample (n = 7840), birthweight was negatively associated with risk for nearsightedness (odds ratio OR = 0.76, 95% CI: 0.65 - 0.92) and minimal brain disorder (OR = 0.27, 95% CI: 0.16-0.44) when adjusted for gestational age, sex, zygosity, age, education and body mass index after correction for intraclass correlations and multiple comparisons. Within-pair analysis of 159 MZ and 224 DZ pairs revealed that myopic twins were on average 2 g (p = .966) and 64 g (p = .040) lighter than nonmyopic twins in MZ and DZ pairs respectively, suggesting that genetic factors may play an important role in the associations between birthweight and nearsightedness. Within-pair analysis of twins discordant for a minimal brain disorder indicated that affected twins were 80 g (p = .655) and 85 g (p = .655) lighter than their healthy co-twins in MZ and DZ pairs respectively, although there were only 2 MZ and 2 DZ discordant pairs. PMID:15901478

Grjibovski, Andrej M; Harris, Jennifer R; Magnus, Per

2005-04-01

150

Reversible twinning in pure aluminum.  

PubMed

Twinning in metals is normally a permanent plastic deformation mechanism. Here we report reversible twinning in high stacking fault energy (SFE) aluminum. Twinning and spontaneous detwinning at the crack tip have been captured in situ during tensile straining under a transmission electron microscope. Both the in situ observation and the molecular dynamics simulations reveal a two-stage detwinning process. The high propensity for detwinning is due to the high SFE and the low frictional forces against the detwinning partial dislocations in Al. This discovery of reversible twinning has implications for the deformation of other high SFE materials. PMID:19519041

Li, B Q; Sui, M L; Li, B; Ma, E; Mao, S X

2009-05-20

151

[Twins in myth (author's transl)].  

PubMed

Twins have an important place in mythology and a sacred character appears to be attached to them since the most ancient times. In ancient Egypt, the royal placenta was worshipped, being considered as the Pharao's twin (a conception that is still alive among certain African populations), and actually everyone was considered to possess a spiritual twin, the Ka or astral body, through whom it was supposed to be possible to operate with magic rituals and hit enemies. Twin gods were worshipped by Babylonians and Assyrians (who even introduced them among astronomic constellations), and may be also found in the Persian and Veda religions. In the classic, Greco-Roman world, the examples of twin gods and heroes are innumerable: from the twin sons of Zeus, the Dioscuri, to the opposite-sexed twin gods Apollo and Diana, to Rome's founders, Romulus and Remus, etc. Since the most ancient times, a magic conception is connected to the twins, either in a positive or a negative sense, but often with some kind of a "fatidic" aspect. Such a two-faced approach to the phenomenon of twinning, that variously characterizes near-east, protomediterranean, classic, and other ancient civilizations, may still be found in contemporary primitive societies. PMID:801409

de Rachewiltz, B; Parisi, P; Castellani, V

1976-01-01

152

Contemporary management of complicated monochorionic twins.  

PubMed

Monochorionic twins are at increased risk for unique complications including twin-twin transfusion syndrome (TTTS), selective intrauterine growth restriction (sIUGR), and twin-reversed arterial perfusion (TRAP) sequence. Twin-twin transfusion syndrome is treated with laser photocoagulation whereas selective reduction is an option in previable sIUGR or TRAP sequence. The nurse is integral in the management, education, care and support of women with complicated pregnancies. PMID:22536818

Moise, Karen Y; Kugler, Lisa; Jones, Tyra

2012-04-26

153

Twin-Twin Transfusion Syndrome: The Surgical Removal of One Twin as a Treatment Option  

Microsoft Academic Search

The twin-twin transfusion syndrome, associated with acute polyhydramnios in the 18th to 28th week of gestation, has a high perinatal mortality rate. Patients managed without intervention have essentially a 100% mortality rate for the involved twins. Different methods of intervention have been described, including therapeutic amniocentesis, selective feticide, and placental vessel puncture. In this case report we describe selective removal

Michael A. Urig; Gary F. Simpson; John P. Elliott; William H. Clewell

1988-01-01

154

Placental pathophysiology of the twin oligohydramnios-polyhydramnios sequence and the twin-twin transfusion syndrome.  

PubMed

Currently accepted sonographic criteria for antenatal diagnosis of twin-twin transfusion (TTT) syndrome include a monochorionic placenta with same-sex twins, marked growth discordance, and oligohydramnios of the growth-retarded twin with coexistent polyhydramnios of the larger twin. Our previous report of nine women fulfilling these criteria, examined using sequential funipuncture of both fetuses, demonstrated inter-twin blood transfusion in only four cases (44 per cent). It was proposed that traditional sonographic criteria actually describe a heterogeneous group of disorders more appropriately described as the twin oligohydramnios-polydramnios sequence (TOPS). True TTT is a subset of this population, the antenatal diagnosis of which requires specific demonstration of transfusion from one fetus (donor) to the other (recipient). In this report, antenatal placental evaluation has been correlated using duplex pulsed-wave Doppler analysis of arterial blood flow velocity with postpartum gross and histopathologic evaluation of the placenta, with special attention to microvasculature. There was a higher incidence of resistance to blood flow, abnormal umbilical cord insertion, and diminished placental microvasculature associated with oligohydramnic growth-retarded (donor) twins when compared with polyhydramnic (recipient) twins. Based on these observations, it is proposed that TTT and TOPS represent asymmetric placental insufficiency resulting from aberrant placentation. PMID:9481789

Bruner, J P; Anderson, T L; Rosemond, R L

1998-01-01

155

Neonatal morbidity in twin-twin transfusion syndrome.  

PubMed

Twin-twin transfusion syndrome (TTTS) is a severe complication of monochorionic twin pregnancies associated with high perinatal mortality and morbidity rates. Management in TTTS is a major challenge for obstetricians and neonatologists. Twins which are often born prematurely and may suffer from typical conditions associated with prematurity. In addition, surviving twins with TTTS are at increased risk for other complications including neurological, cardiovascular, renal and hematologic morbidity. Rare complications such as hypoxic-ischemic lesions to limbs or intestines and amniotic band syndrome have also been reported in TTTS survivors. This review focuses on the neonatal and pediatric mortality and morbidity in TTTS survivors, with special emphasis on the long-term neurodevelopmental outcome. PMID:21784588

Lopriore, Enrico; Oepkes, Dick; Walther, Frans J

2011-07-23

156

On deformation twins and twin-related lamellae in TiAl  

Microsoft Academic Search

The crystal orientation relationships and atomic arrangements across deformation twin planes and twin-related lamellar interfaces in projection directions in TiAl are examined crystallographically. Atomic arrangements across the true-twin plane and the true-twin-related lamellar interface are shown to be identical, while the atomic arrangements across the pseudo-twin plane and the pseudo-twin-related lamellar interface are quite different. Atom locations at the true-twin

Zhe Jin; G. T Gray

1998-01-01

157

Transformation: From Twin to Individual  

ERIC Educational Resources Information Center

|This article explores some of the complexities of psychotherapy with an identical twin. The difficulty of developing in psychotherapy while so much of what is oneself is located in the other twin will also be explored. The use of the countertransference as a therapeutic method will be considered as the young person develops her unique, separate…

Magagna, Jeanne

2007-01-01

158

Conjoined twins in West Africa  

Microsoft Academic Search

12 cases of conjoined twins from West Africa were reported between 1936 and 1978. Eight sets were liveborn and were surgically separated either in local hospitals or abroad. Four were stillborn. Two new cases of stillborn conjoined twins were recently delivered at this hospital. The most common type and the ones most likely to be born alive were the omphalopagi.

O A Mabogunje; J H Lawrie

1980-01-01

159

Voice similarity in identical twins.  

PubMed

If people are asked to discriminate visually the two individuals of a monozygotic twin (MT), they mostly get into trouble. Does this problem also exist when listening to twin voices? Twenty female and 10 male MT voices were randomly assembled with one "strange" voice to get voice trios. The listeners (10 female students in Speech and Language Pathology) were asked to label the twins (voices 1-2, 1-3 or 2-3) in two conditions: two standard sentences read aloud and a 2.5-second midsection of a sustained /a/. The proportion correctly labelled twins was for female voices 82% and 63% and for male voices 74% and 52% for the sentences and the sustained /a/ respectively, both being significantly greater than chance (33%). The acoustic analysis revealed a high intra-twin correlation for the speaking fundamental frequency (SFF) of the sentences and the fundamental frequency (F0) of the sustained /a/. So the voice pitch could have been a useful characteristic in the perceptual identification of the twins. We conclude that there is a greater perceptual resemblance between the voices of identical twins than between voices without genetic relationship. The identification however is not perfect. The voice pitch possibly contributes to the correct twin identifications. PMID:11256192

Van Gysel, W D; Vercammen, J; Debruyne, F

2001-01-01

160

The Essene's sister sect in Egypt: another medical site?  

PubMed

The Essenes were, allegedly, the authors of the Dead Sea Scrolls and were settled by the Dead Sea. An ancient source locates their sister sect, The 'Therapeutae', as being by the shores of Lake Mareotis in Egypt. No scholar has previously sought to locate where exactly on Lake Mareotis they were settled. Using clues from Essene sites around the Dead Sea, an attempt is made to suggest a specific location for the Therapeutae. Since there are signs of medical activity at many of the Essene sites, a site with medical association is also sought for the location of the Essene's sister sect in Egypt. A suitable site is found at Canopus. PMID:12557736

Moss, G A

2002-12-01

161

Catholic Sister Nurses in Selma, Alabama, 1940-1972  

PubMed Central

This study analyzes the activities of religious sister nurses as they confronted racism in the American South from 1940 to 1972. Selma was chosen as a case study because, in the 1960s, events in that southern town marked a turning point in the civil rights movement in the United States. This is a story about the workings of gender, race, religion, and nursing. The sisters’ work demonstrates how an analysis of race in nursing history is incomplete without an understanding of the roles that a number of Catholic religious women took in reaching out to African Americans in the Deep South.

Wall, Barbra Mann

2009-01-01

162

Twin Language Development: A Case Study of a Twin with a Cochlear Implant and a Twin with Typical Hearing  

ERIC Educational Resources Information Center

This study was a longitudinal examination (21 month follow-up) of language development in a pair of fraternal twins. One twin received a cochlear implant at age 20 months secondary to sensorineural hearing loss. The other twin had normal hearing. Data were obtained every 6 months following her initial cochlear implant stimulation. Both twins

Seung, HyeKyeung; Holmes, Alice; Colburn, Michelle

2005-01-01

163

Pathophysiology of Polyhydramnios in Twin Transfusion Syndrome  

Microsoft Academic Search

In 3 cases of severe twin transfusion syndrome we demonstrate that the concentration of atrial natriuretic factor (ANF) in the cord blood of recipient twins is significantly elevated compared to that of donor twins. The discrepancy between recipient and donor concentration correlates with the volume of transfusion. The following pathophysiological mechanism for explaining polyhydramnios in recipient twins is proposed: chronic

Peter Wieacker; Christian Wilhelm; Heinrich Prömpeler; Karl-Georg Petersen; Helmuth Schillinger; Meinert Breckwoldt

1992-01-01

164

CONTRIBUTIONS OF TWIN RESEARCH TO PSYCHOLOGY  

Microsoft Academic Search

AFTER REVIEWING SOME CRITICISMS OF THE TWIN METHOD, PARTIAL REPLIES TO THESE ARE SUGGESTED. STATISTICAL METHODS FOR THE ANALYSIS OF TWIN DATA ARE DISCUSSED, INCLUDING SOME NEW IDEAS ABOUT MULTIVARIATE ANALYSIS OF TWIN DATA. THE REMAINDER OF THE PAPER SUMMARIZES RECENT TWIN STUDIES ON PHYSIOLOGICAL AND SENSORY VARIABLES, PERCEPTUAL TASKS, MOTOR SKILL, COGNITIVE VARIABLES, AND PERSONALITY. RECOMMENDATIONS FOR FUTURE RESEARCH

STEVEN G. VANDENBERG

1966-01-01

165

Ischiopagus and pygopagus conjoined twins: neurosurgical considerations  

Microsoft Academic Search

Background Neurosurgeons are familiar with the challenges presented by craniopagus twins, but other types of conjoined twins may also have neurosurgical implications. We report our experience in the management of ischiopagus and pygopagus conjoined twins. Methods This is a retrospective review of the management of conjoined twins at Red Cross Children’s Hospital in Cape Town, South Africa. Results Twenty-three pairs

A. Graham Fieggen; Robert N. Dunn; R. Dick Pitcher; Alastair J. W. Millar; Heinz Rode; Jonathan C. Peter

2004-01-01

166

Best Practices for Twin Placement in School  

ERIC Educational Resources Information Center

The children's book "Two Is for Twins" celebrates twins and illustrates the many "twos" in a child's world. The uniqueness of twos does not have to mean separate classrooms for twins in child development programs, preschool, or elementary school settings. With recent dramatic increases in the US twin population, how should educators address the…

Lacina, Jan

2012-01-01

167

Twin pregnancy and the risk of schizophrenia  

Microsoft Academic Search

BackgroundTwins are exposed to intrauterine environments that differ significantly from those of singletons. These diverse environments might alter the risk for schizophrenia in twins and make it difficult to generalize from findings in twins when studying the risk of schizophrenia in the general population. Previous studies report contradictory findings on the risk for schizophrenia in twins.

K. Kleinhaus; S. Harlap; M. C. Perrin; O. Manor; R. Calderon-Margalit; Y. Friedlander; D. Malaspina

2008-01-01

168

Healthy Eating  

NSDL National Science Digital Library

Questions to Know Beforehand: Image How much food does your body need, daily? What types of food help your body function at its best? What else does your body need to stay healthy? Use the following links to assist you in classifying healthy and not-so-healthy food options and more. Food Nutrition NOVA ...

Anderson, Kate

2012-04-30

169

Hearing My Mother's Voice: A Study of Sisters and Mothers.  

ERIC Educational Resources Information Center

There seems to be an assumption among many people that parents can mold the later adult personality of their offspring by manipulating their childhood upbringing. To tease out the variables in childrearing and to discover some of the sources of the childbearing practices of mothers in the 1980s, a study of sisters and their mothers (N=48) in the…

Morris, Beverley

170

Genetic relatedness to sisters' children has been underestimated.  

PubMed

Males of many species help in the care and provisioning of offspring, and these investments often correlate with genetic relatedness. For example, many human males invest in the children of sisters, and this is especially so where men are less likely to share genes with children of wives. Although this makes qualitative sense, it has been difficult to support quantitatively. The prevailing model predicts investment in children of sisters only when paternity confidence falls below 0.268. This value is often seen as too low to be credible; so investment in sisters' children represents an unsolved problem. I show here that the prevailing model rests on a series of restrictive assumptions that underestimate relatedness to sisters' children. For this reason, it understates the fitness payoff to men who invest in these children. This effect can be substantial, especially in societies with low confidence in paternity. But this effect cannot be estimated solely from confidence in paternity. One must also estimate the probability that two siblings share the same father. PMID:23193121

Rogers, Alan R

2013-01-22

171

Chromosome breakage and rejoining of sister chromatids in Bloom's syndrome  

Microsoft Academic Search

The occurrence of chromosome breaks and reunion of sister chromatids in lymphocytes of two patients with Bloom's syndrome has been compared with those found in X-rayed and control cells. The distribution of breaks in BS is non-random both between and within chromosomes, the centric regions of certain chromosomes being preferentially involved. The following working hypotheses are put forward: When chromosome

Evelyn Meyer Kuhn; Eeva Therman

1979-01-01

172

Uncoupling of sister replisomes during eukaryotic DNA replication  

PubMed Central

Summary The duplication of eukaryotic genomes involves the replication of DNA from up to several hundred thousand origins of replication. In S phase, two sister replisomes are assembled at each active origin, and they replicate DNA in opposite directions. Little is known about the functional relationship between sister replisomes in S phase. Some data imply that they travel away from one another and thus function independently. However, other studies suggest that sister replisomes form a stationary, functional unit that draws parental DNA towards itself. If this ‘double replisome’ model is correct, an extended DNA molecule whose ends are fixed in space should not undergo replication. To test this prediction, lambda DNA (50 kb) was stretched and immobilized at both ends within a microfluidic flow cell. Upon exposure to replication-competent Xenopus egg extracts, this DNA underwent extensive replication by a single pair of diverging replisomes. The data show that there is no obligatory coupling between sister replisomes and, together with other studies, imply that genome duplication is carried out by individual, autonomously functioning replisomes.

Yardimci, Hasan; Loveland, Anna B.; Habuchi, Satoshi; van Oijen, Antoine M.; Walter, Johannes C.

2010-01-01

173

7. STREAMSIDE PATH BETWEEN THREE BRIDGE FALLS AND THREE SISTERS ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. STREAM-SIDE PATH BETWEEN THREE BRIDGE FALLS AND THREE SISTERS FALLS, LOOKING WEST Photocopy of photograph, 1930s National Park Service, National Capital Region files - Dumbarton Oaks Park, Thirty-second & R Streets Northwest, Washington, District of Columbia, DC

174

Giemsa technique for the detection of sister chromatid exchanges  

Microsoft Academic Search

Sister chromatid exchanges are sharply demarcated in Giemsa stained metaphase preparations of Chinese hamster ovary cells and human peripheral leukocytes. Chromatids singly and doubly substituted with BrdU acquire differential Giemsa stain affinities after treatment at 88° C for 10 minutes in 1.0 M Na phosphate buffer (pH 8.0).

Julie R. Korenberg; Elizabeth F. Freedlender

1974-01-01

175

Ultrasonic induction of sister chromatid exchanges in human lymphocytes  

Microsoft Academic Search

We analyzed sister chromatid exchange (SCE) frequencies as an indicator of DNA damage induced in human lymphocytes by ‘real-time’ ultrasound. A range of exposure times and intensities was tested in a series of blind, randomized, in vitro experiments under spatial and sonographic conditions simulating exposure of a gravid abdomen and uterus. Our studies showed small but consistent effects of ultrasound

Michael Haupt; Alice O. Martin; Joe Leigh Simpson; M. Anwaruddin Iqbal; Sherman Elias; Alan Dyer; Rudy E. Sabbagha

1981-01-01

176

Meiotic sister chromatid cohesion and recombination in two filamentous fungi  

Microsoft Academic Search

Homologous recombination and sister chromatid cohesion play important roles in the maintenance of genome integrity and the fidelity of chromosome segregation in mitosis and meiosis. Within the living cell, the integrity of the DNA is threatened by various factors that cause DNA-lesions, of which DNA double-strand breaks (DSBs) are considered particularly deleterious. The causative agents can be of endogenous origin,

Heemst van D

2000-01-01

177

Chromosome condensation and sister chromatid pairing in budding yeast  

Microsoft Academic Search

We have developed a fluorescent in situ hy- bridization (FISH) method to examine the structure of both natural chromosomes and small artificial chromo- somes during the mitotic cycle of budding yeast. Our results suggest that the pairing of sister chromatids: (a) occurs near the centromere and at multiple places along the chromosome arm as has been observed in other eukaryotic

Vincent Guacci; Eileen Hogan; Douglas Koshland

1994-01-01

178

Prenatal ultrasonographic diagnosis of acardiac twin.  

PubMed

Acardiac twinning is a rare complication of monozygotic twin gestation occurring in 1/35,000 pregnancies or in 1% of all monozygotic twins. This condition is characterized by partial or complete lack of development of the heart in one of the twins, and requires that the normal twin (pump twin) provides circulation for itself as well as the acardiac sibling (perfused twin) by means of reverse circulation through large artery-to-artery and vein-to-vein anastomoses. The acardiac anomaly is uniformly fatal for the perfused twin, and the perinatal mortality for the normal twin is about 50%, usually as the result of congestive heart failure, polyhydramnios, and preterm delivery. In this report we present two cases of acardiac twin prenatally diagnosed by ultrasound. The principal sonographic features for prenatal diagnosis and the clinical management are briefly discussed. PMID:8229616

Sepúlveda, W H; Quiroz, V H; Giuliano, A; Henríquez, R

1993-01-01

179

[Prenatal diagnosis in twin pregnancy].  

PubMed

There are some unique problems of prenatal diagnosis and genetic counselling of twins, although methods of evaluation are similar in multiply and singleton pregnancies. Indications, risk and complications of this techniques were described. Also sensitivity and specificity of biochemic screening examination were compared between singleton and multiply pregnancy. Prenatal diagnosis based on amniopunction and chorionbiopsy seems to be safe and useful method determining aneuploidy. The risk of this methods is higher in twins than in singleton pregnancies. Although, in twin pregnancies, it is related rather to higher complications rate, than to procedures pregnancies losses. PMID:11216162

Szymula, D; Leszczy?ska-Gorzelak, B; Marciniak, B; Oleszczuk, J

2000-11-01

180

20 CFR 222.40 - When determinations of relationship are made for parent, grandchild, brother or sister.  

Code of Federal Regulations, 2013 CFR

...determinations of relationship are made for parent, grandchild, brother or sister. 222...FAMILY RELATIONSHIPS Relationship as Parent, Grandchild, Brother or Sister § 222...determinations of relationship are made for parent, grandchild, brother or sister....

2013-04-01

181

Developmental origins and impact of BCR-ABL1 fusion and IKZF1 deletions in monozygotic twins with Ph+ acute lymphoblastic leukemia.  

PubMed

The timing and developmental sequence of events for BCR-ABL1(+) acute lymphoblastic leukemia (ALL), usually associated with IKAROS (IKZF1) deletions, are unknown. We assessed the status of BCR-ABL1 and IKZF1 genes in 2 pairs of monozygotic twins, one pair concordant, the other discordant for Philadelphia chromosome positive (Ph(+)) ALL. The twin pair concordant for ALL shared identical BCR-ABL1 genomic sequence indicative of monoclonal, in utero origin. One twin had IKZF1 deletion and died after transplantation. The other twin had hyperdiploidy, no IKZF1 deletion, and is still in remission 8 years after transplantation. In the twin pair discordant for ALL, neonatal blood spots from both twins harbored the same clonotypic BCR-ABL1 sequence. Low level BCR-ABL1(+) cells were present in the healthy co-twin but lacked the IKZF1 deletion present in the other twin's leukemic cells. The twin with ALL relapsed and died after transplantation. The co-twin remains healthy and leukemia free. These data show that in childhood Ph(+) ALL, BCR-ABL1 gene fusion can be a prenatal and possibly initiating genetic event. In the absence of additional, secondary changes, the leukemic clone remains clinically silent. IKZF1 is a secondary and probable postnatal mutation in these cases, and as a recurrent but alternative copy number change is associated with poor prognosis. PMID:21960589

Cazzaniga, Giovanni; van Delft, Frederik W; Lo Nigro, Luca; Ford, Anthony M; Score, Joannah; Iacobucci, Ilaria; Mirabile, Elena; Taj, Mary; Colman, Susan M; Biondi, Andrea; Greaves, Mel

2011-09-29

182

Developmental origins and impact of BCR-ABL1 fusion and IKZF1 deletions in monozygotic twins with Ph+ acute lymphoblastic leukemia  

PubMed Central

The timing and developmental sequence of events for BCR-ABL1+ acute lymphoblastic leukemia (ALL), usually associated with IKAROS (IKZF1) deletions, are unknown. We assessed the status of BCR-ABL1 and IKZF1 genes in 2 pairs of monozygotic twins, one pair concordant, the other discordant for Philadelphia chromosome positive (Ph+) ALL. The twin pair concordant for ALL shared identical BCR-ABL1 genomic sequence indicative of monoclonal, in utero origin. One twin had IKZF1 deletion and died after transplantation. The other twin had hyperdiploidy, no IKZF1 deletion, and is still in remission 8 years after transplantation. In the twin pair discordant for ALL, neonatal blood spots from both twins harbored the same clonotypic BCR-ABL1 sequence. Low level BCR-ABL1+ cells were present in the healthy co-twin but lacked the IKZF1 deletion present in the other twin's leukemic cells. The twin with ALL relapsed and died after transplantation. The co-twin remains healthy and leukemia free. These data show that in childhood Ph+ ALL, BCR-ABL1 gene fusion can be a prenatal and possibly initiating genetic event. In the absence of additional, secondary changes, the leukemic clone remains clinically silent. IKZF1 is a secondary and probable postnatal mutation in these cases, and as a recurrent but alternative copy number change is associated with poor prognosis.

van Delft, Frederik W.; Lo Nigro, Luca; Ford, Anthony M.; Score, Joannah; Iacobucci, Ilaria; Mirabile, Elena; Taj, Mary; Colman, Susan M.; Biondi, Andrea

2011-01-01

183

Twin-to-twin transfusion syndrome: from placental anastomoses to long-term outcome  

Microsoft Academic Search

Twin-to-twin transfusion syndrome (TTTS) is a severe complication of monochorionic twin pregnancies associated with high perinatal mortality and morbidity rates. Placental vascular anastomoses, almost invariably present in monochorionic placentas, are the essential anatomical substrate for the development of TTTS. TTTS is thought to result from unbalanced inter-twin blood flow between the donor twin and the recipient twin through the vascular

Enrico Lopriore

2006-01-01

184

Leptin and bone turnover in monochorionic twins complicated by twin–twin transfusion syndrome  

Microsoft Academic Search

Introduction  To test the hypothesis that the bone metabolism of a growth-restricted foetus is regulated by genetic, placental and\\/or foetal\\u000a factors through leptin, we investigated the foetal bone turnover in monochorionic pregnancies complicated with or without\\u000a twin–twin transfusion syndrome (TTTS).\\u000a \\u000a \\u000a \\u000a Methods  Maternal and cord bloods were collected from gestational-age-matched monochorionic twins with (n?=?15) and without (n?=?15) TTTS. The samples were assayed for

R. Bajoria; S. R. Sooranna; R. Chatterjee

2007-01-01

185

Management of pyopagus conjoined twins  

Microsoft Academic Search

IntroductionApproximately 18% of conjoined twins (1 in 200,000 live births) are joined at the sacrum (“pyopagus”). As the joined structures are not life-threatening, there is generally a good prognosis, with time for investigation and planning of operative separation.Case report This paper reports on the management of pyopagus twin girls, the first in the UK delivered at 36 weeks by Caesarean section.

Anthony D. Hockley; Peter Gornall; Richard Walsh; Hiroshi Nishikawa; Hiu Lam; Lesley MacPherson; Jeff Bissenden; Gabrielle Downey; Lewis Spitz

2004-01-01

186

Twinning of rhombic colloidal crystals.  

PubMed

We observe twinning of two-dimensional (2D) rhombic colloidal crystals of hard Brownian rhombic platelets. By contrast to square particles, which have higher symmetry but can also form rhombic lattices at high densities, each rhombic particle has a distinguishable bidirectional pointing axis. This key feature, which is not readily seen in rhombic crystals of square colloids, facilitates observations of different types of twinning: contact, polysynthetic, and cyclic. Moreover, we find that the twinned crystals are slightly offset spatially along their shared mirror line. In addition, the average pointing axis of the particles in a single crystal is also offset on average by a small angle, either clockwise or counterclockwise, from the average pointing axis of the rhombic lattice yielding a form of nonlocal chiral symmetry breaking. Because mirror lines between contact twins introduce only a small reduction in the total number of accessible states, compared to a perfect single crystal, twinning and piecewise linear defects are commonly observed. Thus, twinning, which is usually associated with complex compositions in certain minerals, also emerges in a simpler 2D system of entropically driven, hard, achiral objects. PMID:23075224

Zhao, Kun; Mason, Thomas G

2012-10-18

187

A general method to determine twinning elements  

PubMed Central

The fundamental theory of crystal twinning has been long established, leading to a significant advance in understanding the nature of this physical phenomenon. However, there remains a substantial gap between the elaborate theory and the practical determination of twinning elements. This paper proposes a direct and simple method – valid for any crystal structure and based on the minimum shear criterion – to calculate various twinning elements from the experimentally determined twinning plane for Type I twins or the twinning direction for Type II twins. Without additional efforts, it is generally applicable to identify and predict possible twinning modes occurring in a variety of crystalline solids. Therefore, the present method is a promising tool to characterize twinning elements, especially for those materials with complex crystal structure.

Zhang, Yudong; Li, Zongbin; Esling, Claude; Muller, Jacques; Zhao, Xiang; Zuo, Liang

2010-01-01

188

Annealing twins in nominally pure Al  

SciTech Connect

Classic examples of annealing twins were observed in Al which was sufficiently pure due to Fe precipitation such that continuous recrystallization could occur. The twin formation at triple junctions is due to energy reduction on both sides bounding the twinned grain. The low frequency of such twins illustrates that twin boundary energy in Al is indeed comparable to large angle boundary energy. The observation of many {Sigma}3 oriented grains without readily distinguishable planar boundaries supports this conclusion. The formation of parallel twins is assisted by stored work whereby the dislocated structure is eliminated by the migration of incoherent twin boundaries. If the bounding recrystallized region envelops the twin band, the driving force is lost and the twin band shrinks.

Li, J.; Saimoto, S. [Queen`s Univ., Kingston, Ontario (Canada). Dept. of Materials and Metallurgical Engineering; Seki, F.; Itoh, K. [Univ. of Tokyo (Japan). Dept. of Materials Science; Kamijo, T. [Yokohama National Univ. (Japan). Dept. of Mechanical Engineering

1997-06-01

189

False belief and emotion understanding in monozygotic twins, dizygotic twins and non-twin children  

Microsoft Academic Search

This study investigated the understanding of false belief and emotion in monozygotic (MZ) and same-sex dizygotic (DZ) twin pairs compared to non-twin children. Aged 3;9 to 5;1 years, the children (N=123) were administered three false belief and three emotion understanding tasks. Age, family socioeconomic status, mother's level of education and language abilities were controlled. Results showed no difference between the

Joane Deneault; Marcelle Ricard; Thérèse Gouin Décarie; Pierre L. Morin; Germain Quintal; Michel Boivin; Richard E. Tremblay; Daniel Pérusse

2008-01-01

190

Brothers and sisters of young children with communication disorders.  

PubMed

Family-centered approaches have revolutionized the way that clinicians provide services to young children with communication disorders and their families. With greater recognition of the significant impact that siblings have on each other's development and the potential stress and role confusion that siblings may experience when there is childhood disability in the family, it becomes more critical that the needs of siblings are considered and addressed. In this article, a variety of issues are considered relative to siblings' experiences. First, the roles of siblings and their effects on each other's development is reviewed, followed by a historical perspective of the impact of childhood disability on brothers and sisters. Next, sibling roles relative to a brother or sister with a communication disability are considered. Finally, clinical implications are discussed, with specific reference to active inclusion of siblings in family-centered assessment and intervention efforts. PMID:9306519

Prizant, B M; Meyer, E C; Lobato, D J

1997-01-01

191

Religious activities and health outcomes: the College Bound Sisters Program.  

PubMed

College Bound Sisters (CBS) is a program that helps younger sisters of teenage mothers change their life trajectory by accomplishing three objectives: avoidance of pregnancy, completion of high school, and enrollment in college. Data related to religious activities and accomplishment of the three objectives for 129 members were analyzed using chi square. CBS defines health as the accomplishment of the three program objectives using Norbeck's theoretical model of social support. The adolescents were divided into three groups: those who became pregnant, dropped out of school, or completed high school. The three groups were compared with regard to the frequency of participating in religious activities. The majority of the CBS adolescents reported participating in weekly religious activities. No significant difference was found among the three groups, with regard to religious activities. However, CBS program participants were more likely than nonparticipants to graduate high school and enroll in college. Implications for incorporating religious activities in teenage pregnancy prevention programs are discussed. PMID:16418079

Smith, Lauren W; Brown, Hazel N; Lewallen, Lynne P; Penny, Judith M

192

Sister chromatid junctions in the hyperthermophilic archaeon Sulfolobus solfataricus  

PubMed Central

Although the Archaea exhibit an intriguing combination of bacterial- and eukaryotic-like features, it is not known how these prokaryotic cells segregate their chromosomes before the process of cell division. In the course of our analysis of the third replication origin in the archaeon Sulfolobus solfataricus, we identify and characterise sister chromatid junctions in this prokaryote. This pairing appears to be mediated by hemicatenane-like structures, and we provide evidence that these junctions persist in both replicating and postreplicative cells. These data, in conjunction with fluorescent in situ hybridisation analyses, suggest that Sulfolobus chromosomes have a significant period of postreplicative sister chromatid synapsis, a situation that is more reminiscent of eukaryotic than bacterial chromosome segregation mechanisms.

Robinson, Nicholas P; Blood, Katherine A; McCallum, Simon A; Edwards, Paul A W; Bell, Stephen D

2007-01-01

193

A classic twin study of isolated gastroschisis.  

PubMed

The etiology of gastroschisis remains elusive. A classic twin study was used to assess the relative contribution of environmental and genetic factors in its development. Screening of 4872 twin pregnancies identified three unreported twin pairs comprising two monozygous and one dizygous discordant pair of twins. Review of the literature identified an additional 21 twin pairs. We observed lower pair- and proband-wise concordance rates for monozygotic compared to dizygotic twin pairs, pair- and proband-wise concordance ratios below 1.0. Our results suggest environmental to play a greater role than genetic factors in the development of gastroschisis. PMID:22433012

Schulz, Anna Carina; Stressig, Rüdiger; Ritgen, Jochen; Bagci, Soyhan; Müller, Andreas; Gembruch, Ulrich; Geipel, Annegret; Berg, Christoph; Bartmann, Peter; Reutter, Heiko Martin

2012-03-20

194

The Chinese National Twin Registry: an update.  

PubMed

The Chinese National Twin Registry (CNTR), established in 2001, is the first and largest population-based twin registry in China. Based on the CNTR, a new twin cohort was recruited from 2011 to study the relationship between environmental risk factors and chronic diseases. So far, 33,874 twin pairs from nine provinces have been recruited, in which hundreds of disease-discordant twin pairs and even thousands of exposure-discordant twin pairs were found in this cohort. The updates of the CNTR will be introduced in detail in this article. PMID:23298737

Li, Liming; Gao, Wenjing; Yu, Canqing; Lv, Jun; Cao, Weihua; Zhan, Siyan; Wang, Shengfeng; Wu, Chaoqun; Hu, Yonghua

2013-01-08

195

Left abomasal displacement between the uterus and rumen during bovine twin pregnancy  

PubMed Central

Here, we describe two cases of left displaced abomasum (LDA) in Holstein cattle at 6 and 9 months of twin gestation. Clinical examination revealed signs of proximal ileus with marked abdominal distension, but no ping sounds. An unusually high position of the gravid uterine horn on the left side was observed with ultrasound. Left exploratory laparotomy confirmed that the abomasum was displaced to the left and entrapped between the rumen and twin gravid uterine horn. A left surgical approach was necessary to correct the condition. Both animals recovered and gave birth to healthy twins. The present cases indicate that the subomental position of a heavy twin gravid uterine horn is a possible mechanical cause of LDA.

Vertenten, Geert; Cornillie, Pieter; Schauvliege, Stijn; Gasthuys, Frank; van Loon, Gunther; Deprez, Piet

2012-01-01

196

Bold Vision: Catholic Sisters and the Creation of American Hospitals  

Microsoft Academic Search

American hospitals were started by religious, ethnic and community groups to serve local health care needs. Immigration into\\u000a the eastern cities and the constant movement west of the frontier required the creation of educational and service facilities\\u000a to serve these populations and localities. In the nineteenth century, Catholic sisters went all across the country establishing\\u000a schools and hospitals. They were

Peter J. Levin

2011-01-01

197

Molecular Rates Parallel Diversification Contrasts between Carnivorous Plant Sister Lineages  

Microsoft Academic Search

In the carnivorous plant family Lentibulariaceae, the bladderwort lineage (Utricularia and Genlisea) is substantially more species-rich and morphologically divergent than its sister lineage, the butterworts (Pinguicula). Bladderworts have a relaxed body plan that has permitted the evolution of terrestrial, epiphytic, and aquatic forms that capture prey in intricately designed suction bladders or corkscrew-shaped lobster-pot traps. In contrast, the flypaper-trapping butterworts

Richard W. Jobson; Victor A. Albert

2002-01-01

198

Sister chromatid exchanges in lymphocytes of petroleum retailers.  

PubMed Central

Occupational exposure to petroleum vapour was assessed in workers employed in suburban petroleum retail outlets. Urinary output of thioethers provided a non-specific estimate of exposure to chemicals metabolised via a mercapturic acid pathway. Urinary d-glucaric acid (DGA) excretion was taken as an estimate of hepatic enzyme activity. Sister chromatid exchange frequency in lymphocytes was used as an indicator of genotoxic response to exposure. Workers were classified according to their employment at self service (where customers operate petrol pumps) or at driveway attended service stations (at which an employee operates the pumps), and according to exposure to cigarette smoke on the basis of urinary cotinine excretion. Prework and postwork urine samples of workers employed at driveway attended petrol stations contained more thioether than did those of self serve workers. When classified according to smoking behaviour there were no statistically significant differences, although thioether excretion tended to be higher in smokers than in nonsmokers. Urinary DGA excretion was similar in the two exposure groups. Cigarette smokers excreted more DGA, however, than nonsmokers. Sister chromatid exchange frequencies were higher in driveway attendants than in self serve personnel. When the influence of cigarette smoking was investigated there was a significant increase of sister chromatid exchange with combined exposure to petrol and cigarette smoking, but not with either factor alone. Correlation analysis showed that urinary cotinine concentrations were positively associated with urinary excretion of thioether and DGA, indicating that cigarette smoke induces the activity of hepatic enzymes and acts as a source of substrates metabolised through a thioether pathway. In conclusion it seems that exposure to petroleum vapour causes increased sister chromatid exchange in circulating lymphocytes of cigarette smokers, possibly as a result of enhanced hepatic conversion of vapour components to reactive metabolites. Urinary thioether output does not clearly discriminate between workers exposed to different amounts of petroleum vapour at retail outlets.

Edwards, J W; Priestly, B G

1993-01-01

199

A combination of sister chromatid differential staining and giemsa banding  

Microsoft Academic Search

Summary  We report a procedure for combining sister chromatid differential staining and G banding in the same metaphase plate. Mammalian\\u000a cells in culture are grown in medium containing 5-bromodeoxyuridine for two cell cycles, and conventional air-dried preparations\\u000a are made. The slides are treated with a trypsin or a urea solution the same way as for regular G banding. This method is

S. Pathak; A. D. Stock; A. Lusby

1975-01-01

200

Factors involved in differential giemsa-staining of sister chromatids  

Microsoft Academic Search

Microspectrophotometric evaluation of differentially stained sister chromatids made it possible to analyse precisely the factors involved in the Giemsa methods. The concentration of Hoechst 33258, pH of the mounting medium, temperature during UV-exposure and the quality (wavelength) of UV-light influenced the differential staining. Exposure of blacklight of 10-5 M Hoechst 33528-stained BrdU-labeled chromosome specimens mounted in McIlvaine buffer (pH 8.0)

Keiko Goto; S. Maeda; Y. Kano; T. Sugiyama

1978-01-01

201

Twin-twin transfusion syndrome: a five year review  

PubMed Central

OBJECTIVE—To determine the incidence, complications, management, and outcome in infants with twin-twin transfusion syndrome (TTTS) over a period of five years.?METHODS—TTTS was diagnosed in monochorionic twins if one was pale and the other plethoric with a haemoglobin difference ? 5 g/100 ml and/or birthweight differences ? 15%.?RESULTS—Eighteen (6.2%) of the 292 twin pairs had TTTS. Eight pairs (44%) had the acute type and the rest (56%) had the chronic type of TTTS. The mean (SEM) intrapair haemoglobin difference in the acute type was 4.8 (2.1) g/100 ml which gave a discordance of 7.1 (4.6)%, whereas that in the chronic type was 6.9 (2.9) g/100 ml and 24.4 (6.1)% respectively. Infants with the acute type had a significantly higher incidence of vaginal delivery (p < 0.03), hypotension (p < 0.025), and respiratory distress (p < 0.01) compared with those with the chronic type. There was no significant difference in the incidence of anaemia, polycythaemia, asphyxia, hypoglycaemia, and hyperbilirubinaemia. Two recipients died in utero as the result of chronic TTTS, while their survivors developed spastic cerebral palsy. There were no neonatal deaths.?CONCLUSIONS—TTTS, although uncommon, may have an adverse neurodevelopmental outcome especially if one twin dies in utero. Prompt recognition and management of the haemodynamic and haematological problems of infants with the acute types of TTTS will result in optimal neurodevelopmental outcome.??

Seng, Y; Rajadurai, V

2000-01-01

202

Genomic sister-disorders of neurodevelopment: an evolutionary approach  

PubMed Central

Genomic sister-disorders are defined here as diseases mediated by duplications versus deletions of the same region. Such disorders can provide unique information concerning the genomic underpinnings of human neurodevelopment because effects of diametric variation in gene copy number on cognitive and behavioral phenotypes can be inferred. We describe evidence from the literature on deletions versus duplications for the regions underlying the best-known human neurogenetic sister-disorders, including Williams syndrome, Velocardiofacial syndrome, and Smith–Magenis syndrome, as well as the X-chromosomal conditions Klinefelter and Turner syndromes. These data suggest that diametric copy-number alterations can, like diametric alterations to imprinted genes, generate contrasting phenotypes associated with autistic-spectrum and psychotic-spectrum conditions. Genomically based perturbations to the development of the human social brain are thus apparently mediated to a notable degree by effects of variation in gene copy number. We also conducted the first analyses of positive selection for genes in the regions affected by these disorders. We found evidence consistent with adaptive evolution of protein-coding genes, or selective sweeps, for three of the four sets of sister-syndromes analyzed. These studies of selection facilitate identification of candidate genes for the phenotypes observed and lend a novel evolutionary dimension to the analysis of human cognitive architecture and neurogenetic disorders.

Crespi, Bernard; Summers, Kyle; Dorus, Steve

2009-01-01

203

Southall Black Sisters. Hannana Siddiqui speaks to Rasna Warah.  

PubMed

Southall Black Sisters, an organization for Asian and Afro-Caribbean women in Great Britain, was established in 1979 at the height of anti-racist protests to address the otherwise neglected issue of women's oppression. The group has campaigned against discriminatory immigration laws, illegal virginity tests at Heathrow airport, domestic violence, and other issues of particular concern to British Asian women. Women who migrate to England for an arranged marriage must remain with their husband at least 1 year or face deportation and denial of any public assistance, placing them at risk of unreported domestic violence. Southall Black Sisters has attempted to raise the public consciousness about domestic violence as a criminal issue and garner support for Asian women who leave abusive husbands. However, no support has been forthcoming from the anti-racist movement, which fears that publicity on domestic violence will create a racist backlash against Asian men. More support has been available for the group's campaign to protect battered women who kill their husbands by removing from the law on provocation the need for an immediate response. Another campaign has involved protests against "bounty hunters" hired by Asian families to return girls who have escaped from arranged marriages in their home country or sexual abuse within their family. Southall Black Sisters attributes many of the problems faced by its clients to a rise in religious fundamentalism and Muslim attempts to reverse the gains of the feminist movement. PMID:12287625

Warah, R

204

Perinatal complications in unaffected sisters of anorexia nervosa patients: testing a covariation model between genetic and environmental factors.  

PubMed

Although perinatal complications are hypothesized to be risk factors for the development of anorexia nervosa (AN), no study to date explored this issue using a discordant sibling design. This type of design allows to explore whether the risk for obstetric complications is itself a consequence of the genetic vulnerability for AN (covariation model) or whether obstetric complications increase the risk of AN independently of (additive model), or in interaction with (interaction model), the disorder's genetic liability. The presence of perinatal complications was assessed through review of the obstetric records of 60 AN subjects, 60 unaffected sisters, and 70 healthy subjects. Unaffected sisters and healthy controls were compared in relation to perinatal characteristics and complications. There was no evidence for an elevated rate of complications in unaffected siblings of AN patients. Mothers with a positive psychiatric history tended to have more perinatal complications. Perinatal complications seem to be independent risk factors that may interact with, but are not caused by, familial risk factors for AN. In terms of prevention, a particular attention should be paid to mothers with a lifetime history of psychiatric disorders. PMID:21193995

Favaro, Angela; Tenconi, Elena; Bosello, Romina; Degortes, Daniela; Santonastaso, Paolo

2010-12-31

205

[Management of twin-to-twin transfusion syndrome].  

PubMed

Twin-to-twin transfusion syndrome (TTTS), also called twin oligoamnios polyhydramnios sequence (TOPS) complicates around 15% of monochorionic pregnancies irrespective of the mode of conception. It is a hemodynamic, and probably hormonal, discordance secondary to imbalanced blood flow through the vascular anastomoses aforementioned. During the last 15 years, a lot of progress has been made in the understanding, diagnosis and treatment of TTTS. Nevertheless, many questions remain unanswered and research is still active in this domain. Fetoscopic laser coagulation of placental vessels is the only treatment addressing the pathophysiology of the syndrome as proven through a randomized controlled study against amnioreduction. This technique has definitely improved overall survival as well as the rate of neurologically intact survival but it still lacks preoperative prognostic markers. PMID:22387235

Chalouhi, G E; Deloison, B; Ville, Y

2012-03-02

206

Cardiac morbidity in twin-twin transfusion syndrome?  

PubMed

Twin-to-twin transfusion syndrome (TTTS) affects about 10% of monochorionic pregnancies and develops when uncompensated unidirectional blood flow from one twin ('donor') to the other ('recipient') causes circulatory imbalance. The cardiac effect of the underlying hypervolemia or endocrine dysregulation, or both, manifests in the recipient as echocardiographic findings of the syndrome-related cardiomyopathy. The Quintero staging system for TTTS has recently been questioned, because more refined measurement of cardiac function may improve evaluation of disease severity and prediction of outcome. Much has been done to increase survival and diminish the cardiac morbidity associated with TTTS. The purpose of this paper was to review the literature on cardiac morbidity associated this syndrome. PMID:22718604

Martins, Yolanda; Silva, Sara; Matias, Alexandra; Blickstein, Isaac

2012-01-10

207

Complications Arising in Twin Pregnancy: Findings of Prenatal Ultrasonography  

PubMed Central

Multifetal gestations are high-risk pregnancies involving higher perinatal morbidity and mortality, and are subject to unique complications including twin oligohydramnios-polyhydramnios sequence, twin-to-twin transfusion syndrome, acardiac twins, conjoined twins, co-twin demise, and heterotopic pregnancies. The purpose of this study is to describe the prenatal ultrasonographic and pathologic findings of these complications.

Kim, Jeong-Ah; Lee, Young Ho; Song, Mi Jin; Min, Jee-Yeon; Lee, Hak Jong; Han, Byoung Hee; Lee, Kyung-Sang; Cho, Byung Jae; Chun, Yi-Kyeong

2003-01-01

208

Heteropagus twins-a tale of two cases.  

PubMed

Heteropagus twinning is a rare occurrence. Parasitic and asymmetric conjoined twins are rarer anomalies of monochorionic monoamniotic twins; which consist of an incomplete twin attached to the fully developed body of the co-twin. We present here two such cases of Heteropagus twinning. PMID:22654336

Das, Sukanta; Ghosh, Dipak; Biswas, Siddhartha; Chattopadhyay, Sarbani; Mitra, Nilanjan; Chakravartty, Sourav; Hossain, Md Zahid; Kumari, Veena

2011-01-26

209

Long term outcome of twin-twin transfusion syndrome  

PubMed Central

AIMS—To compare the perinatal mortality and morbidity of infants with twin-twin transfusion syndrome (TTTS) with those of gestation matched twin controls and to assess the neurodevelopmental outcome of surviving twins with TTTS.?METHODS—A cohort of 17 consecutive pregnancies with TTTS was enrolled over three years together with gestation matched twin pregnancies unaffected by TTTS. Serial amnioreduction for the TTTS pregnancies was performed as appropriate. Perinatal death and neonatal morbidities were recorded for both the TTTS cohort and controls. The TTTS survivors had neurodevelopmental follow up to at least 2 years of age.?RESULTS—In 12 of the pregnancies, serial amniocenteses were performed, but, in five, the infants were born before intervention. The mean gestational age at delivery was 29.1 weeks (range 23-36). There were five intrauterine deaths in the TTTS cohort and six neonatal deaths (survival 68%). In the control group, there was one intrauterine death and five neonatal deaths (survival 82%). Infants in the TTTS group had a greater requirement for inotropes (p = 0.04) and a higher incidence of renal failure (p = 0.005). Periventricular leucomalacia and cerebral atrophy were seen in 17% of the TTTS group, but none of the controls (p = 0.03). The 23 surviving TTTS infants were all followed up, with 22% having significant neurological morbidity: cerebral palsy and global developmental delay.?CONCLUSIONS—Twins with TTTS have high perinatal mortality and neonatal morbidity, and long term neurodevelopmental morbidity in survivors is high. Further investigation into the pathogenesis and management of TTTS is required.??

Cincotta, R; Gray, P; Phythian, G; Rogers, Y; Chan, F

2000-01-01

210

Sister chromatid exchange as an index of chromosome instability in chondrodystrophic chickens (Gallus domesticus).  

PubMed

Commercially bred broiler chickens reared in inadequate breeder-created habitat conditions often suffer from a disease that afflicts their lower limbs, chondrodystrophy. The sister chromatid exchange (SCE) test makes it possible to detect chromosome instability that corresponds with elevated vulnerability of the organism to genotoxic factors of a mutagenic and carcinogenic nature. The frequency of SCE in chromosomes of chondrodystrophic and healthy broilers was analyzed. Chromosome preparations were obtained from our in vitro culture of peripheral blood lymphocytes stained using the fluorescence plus Giemsa technique. The SCE/cell mean of the population under analysis was 6.8 ± 1.6. The SCE/cell mean in the chromosomes of the chondrodystrophic chickens was 8.5 ± 1.0. The healthy chickens had an SCE/cell mean of 5.1 ± 1.3. Statistically significant differences were identified between both chicken groups. Moreover, a higher SCE/cell mean was observed in the males: 6.9 ± 1.7 compared with 6.7 ± 1.7 in the females. However, this difference was not statistically significant. Additionally, SCE incidence in the first 3 biggest autosome pairs (1, 2, 3) was analyzed in detail. The number of identified SCE was proportional to chromosome length. The most exchanges were observed in the proximal region of the chromosomes under analysis. PMID:23243233

Wójcik, E; Andraszek, K; Ciszewska, M; Smalec, E

2013-01-01

211

Twins and Non-twin Siblings: Different Estimates of Shared Environmental Influence in Early Childhood  

Microsoft Academic Search

win studies typically indicate shared environmental influence for cognitive abilities, especially in early childhood. However, across studies, DZ twin correlations tend to be greater than non-twin sibling correlations, suggesting that twin estimates of shared environment are to some extent specific to twins. We tested this hypothesis in a sample of more than 1800 MZ and 1800 same-sex DZ pairs from

Gesina Koeppen-Schomerus; Frank M. Spinath; Robert Plomin

2003-01-01

212

Risk of Persistent Pulmonary Hypertension of the Neonate in Twin-to-Twin Transfusion Syndrome  

Microsoft Academic Search

Background: Chronic twin-to-twin transfusion syndrome (TTTS) is a complication of monochorionic twin gestations and is associated with high perinatal mortality and increased neurological, cardiovascular and renal morbidity. Objective: To report the risk of severe persistent pulmonary hypertension of the newborn (PPHN) in TTTS and discuss the possible association between severe PPHN and TTTS. Methods: All cases of monochorionic twins with

Bas Delsing; Enrico Lopriore; Nico Blom; Arjan B. Te Pas; Frank P. Vandenbussche; Frans J. Walther

2007-01-01

213

Twin-to-Twin Transfusion Syndrome: Selective Feticide by Embolization of the Hydropic Fetus  

Microsoft Academic Search

To improve the outcome of severe twin-to-twin transfusion syndrome with 1 hydropic fetus and to prevent ischemic sequelae in the survivor, we developed a technique of selective feticide by vascular embolization of the most severely damaged twin. Acute second trimester polyhydramnios occurred in 4 biamniotic monochorial twin pregnancies, with 1 fetus normal on ultrasound but the other severely damaged by

Marc Dommergues; Laurent Mandelbrot; Anne-Lyse Delezoide; Marie-Cécile Aubry; Laurent Fermont; Dominique Caputo-Mahieu; Yves Dumez

1995-01-01

214

Brief Report: Autistic Traits in Twins vs. Non-Twins--A Preliminary Study  

ERIC Educational Resources Information Center

|Previous studies have suggested that among affected sib pairs with autism there is an increase in the frequency of twins over what would be expected in comparison to the prevalence of twins in the general population. In this study we sought to determine whether "sub-threshold" autistic traits were more pronounced in twins than in non-twins. The…

Ho, Alexander; Todd, Richard D.; Constantino, John N.

2005-01-01

215

In situ observation of twin boundary migration in copper with nanoscale twins during tensile deformation  

Microsoft Academic Search

In situ transmission electron microscopy observations are reported of the dynamic process of twin boundary migration in Cu with nanoscale twins. The experiment provides the first direct evidence of twin boundary migration via Shockley partial dislocation emission from the twin boundary\\/grain boundary intersections, and reveals that such migration is the dominant deformation mechanism in the initial stage of plastic straining.

Y. B. Wang; M. L. Sui; E. Ma

2007-01-01

216

Cerebral palsy in the surviving twin associated with infant death of the co-twin  

Microsoft Academic Search

BACKGROUNDMonozygotic twins are at greater risk of dying and of serious morbidity than dizygotic twins, and both are at greater risk than singletons. This is only partly explained by the higher proportion of low birthweight infants among twins.AIMTo compare, in same sex and different sex twins, birth weight specific neonatal death rates and cerebral palsy prevalence rates in the surviving

P O D Pharoah

2001-01-01

217

Fetoscopic laser therapy for twin-to-twin transfusion syndrome.  

PubMed

Twin-to-twin transfusion syndrome (TTTS) is a unique and complicated phenomenon occurring in 10-15% of monochorionic gestations. The chronic unbalanced distribution of blood volume across placental anastomoses between the donor and recipient fetuses leads to multisystem organ impairment including maladaptive changes in both fetuses. Fetoscopic selective laser photocoagulation (SLPC) is now established as the primary treatment modality for advanced stages of TTTS. SLPC is also associated with a risk reduction in fetal demise and long-term neurological impairment. PMID:23395141

Khalek, Nahla; Johnson, Mark P; Bebbington, Michael W

2013-02-01

218

Nike Twins Seven Seven: Nigerian Batik Artist.  

ERIC Educational Resources Information Center

|Chronicles the personal and professional life of Nike Twins Seven Seven (born 1951), a Nigerian batik artist, and her husband, Twins Seven Seven, a musician-artist, both of whom have received international acclaim. (BJV)|

LaDuke, Betty

1987-01-01

219

49 CFR 372.221 - Twin Cities.  

Code of Federal Regulations, 2010 CFR

...Transportation 5 2009-10-01 2009-10-01 false Twin Cities. 372.221 Section 372.221 Transportation...ZONES, AND TERMINAL AREAS Commercial Zones § 372.221 Twin Cities. For the purpose of determining commercial...

2009-10-01

220

49 CFR 372.221 - Twin Cities.  

Code of Federal Regulations, 2010 CFR

...Transportation 5 2010-10-01 2010-10-01 false Twin Cities. 372.221 Section 372.221 Transportation...ZONES, AND TERMINAL AREAS Commercial Zones § 372.221 Twin Cities. For the purpose of determining commercial...

2010-10-01

221

Twin paradox on the photon sphere  

NASA Astrophysics Data System (ADS)

We consider another version of the twin paradox. The twins move along the same circular free photon path around the Schwarzschild center. In this case, despite their different velocities, all twins have the same nonzero acceleration. On the circular photon path, the symmetry between the twins situations is broken not by acceleration (as it is in the case of the classic twin paradox), but by the existence of an absolute standard of rest (timelike Killing vector). The twin with the higher velocity with respect to the standard of rest is younger on reunion. This closely resembles the case of periodic motions in compact (nontrivial topology) three-dimensional (3D) space recently considered in the context of the twin paradox by Barrow and Levin [Phys. Rev. A 63, 044104 (2001)], except that in that paper accelerations of all twins were equal to zero and that, in the case considered here, the 3D space has trivial topology.

Abramowicz, Marek A.; Bajtlik, Stanis?aw; Klu?niak, W?odek

2007-04-01

222

Nike Twins Seven Seven: Nigerian Batik Artist.  

ERIC Educational Resources Information Center

Chronicles the personal and professional life of Nike Twins Seven Seven (born 1951), a Nigerian batik artist, and her husband, Twins Seven Seven, a musician-artist, both of whom have received international acclaim. (BJV)

LaDuke, Betty

1987-01-01

223

Congenital diaphragmatic hernia in identical twins  

PubMed Central

Congenital diaphragmatic hernia (CDH, Bochdalek type) is rarely seen in both members of identical twins. Herein, we report a 37 weeks’ twins with CDH along with a brief review of the literature. Both the neonates survived.

Gurbaz, Mustafa T.; Kazez, Ahmet; Bakal, Unal; Tartar, Tugay; Ersoz, Fikret; Colakoglu, Yunus

2012-01-01

224

Term life birth after late abortion of the first twin.  

PubMed

The incidence of multiple pregnancy has increased significantly in recent years as a result of assisted reproductive therapy. The most important complication of these pregnancies remains preterm delivery. We report an extraordinary case of delayed delivery after late abortion of the first twin. Tocolysis successfully prolonged the pregnancy for more than three months, and combined with antibiotics and corticosteroids resulted in a term delivery of a second healthy sibling. A total of 37 reports that describe 145 cases of intentional delayed delivery are available. Delay of delivery may offer significant improvement in survival and outcome for the remaining fetus. Delay of delivery beyond 37 weeks is uncommon with only eight reports. A protocol for the procedure of delayed delivery of the second twin is suggested. PMID:19657759

Wouters, Karlijn A; Gianotten, Judith; Bayram, Neriman; Doornbos, Johannes P R

2009-01-01

225

Twins' injuries: genetic and environmental risks / twin research reports / human interest stories.  

PubMed

The relative contributions of genetic and environmental factors to unintentional injuries are of interest to families with young twins. A recent study found that childhood injuries are explained mostly by child-specific environmental factors. Next, twin research reviews of the association between periodontal disease and cancer, secular trends in gestational age and birthweight, and language development in hearing and deaf co-twins are also summarized. Interesting reports of newborn twins, twin-like relationships, twin interactions and missed twin relationships are presented. PMID:21425906

Segal, Nancy L

2011-04-01

226

Healthy Eating  

NSDL National Science Digital Library

What do you know about healthy eating? Check out the sites below to learn what you should and should not be eating on a daily basis. Before we get started let's see what knowledge you have about healthy eating. What do you think are some of the most healthy foods for you? Do you like to eat these foods? Now look at the sites below and answer the following questions. Blast Off Dining Decisions Nutrients Your Body Neeeds What were some good food choices ...

Sweet, Miss

2012-05-03

227

A Little Twin Higgs Model  

SciTech Connect

We present a twin Higgs model based on left-right symmetry with a tree level quartic. This is made possible by extending the symmetry of the model to include two Z_2 parities, each of which is sufficient to protect the Higgs from getting a quadratically divergent mass squared. Although both parities are brokenexplicitly, the symmetries that protect the Higgs from getting a quadratically divergent mass are broken only collectively. The quadratic divergences of the Higgs mass are thus still protected at one loop. We find that the fine-tuning in this model is reduced substantially compared to the original left-right twin Higgs model. This mechanism can also be applied to the mirror twin Higgs model to get a significant reduction of the fine-tuning, while keeping the mirror photon massless.

Goh, Hock-Seng; Goh, Hock-Seng; Krenke, Christopher A.

2007-07-25

228

Diastolic Cardiac Pathology and Clinical Twin-Twin Transfusion Syndrome in Monochorionic/Diamniotic Twins  

PubMed Central

Objective to identify differences in echocardiographic profiles of monochorionic/diamniotic pregnancies with early or mild twin-twin transfusion syndrome (TTTS), compared to monochorionic/diamniotic twins affected only by discordant growth or discordant fluid. Study Design retrospective evaluation of sonograms and echocardiograms of twin pregnancies referred for suspected TTTS. Results 112 monochorionic/diamniotic pairs were studied. 41 did not have/develop TTTS, 61 had Stage I/II TTTS. Ten developed TTTS after initially not meeting criteria. TTTS recipients had a higher rate of venous Doppler or tricuspid inflow abnormalities than purported “recipients” in non-TTTS pregnancies (86% vs. 37%, P<0.001). TTTS recipients had shorter tricuspid inflow duration/RR intervals than non-TTTS fetuses (32+/?6% versus 37+/?4%, P<0.001). Logistic regression and recursive partitioning identified shorter tricuspid inflow duration, longer isovolumic relaxation, and ductus venosus abnormality associated with TTTS. Conclusion Diastolic pathology, specifically shorter tricuspid inflow duration, may be considered a hallmark of TTTS distinguishing these pregnancies from other monochorionic/diamniotic twin complications.

Moon-Grady, Anita J.; Rand, Larry; Gallardo, Salvador; Gosnell, Kristen; Lee, Hanmin; Feldstein, Vickie A.

2011-01-01

229

On Teaching About Twins and Time  

ERIC Educational Resources Information Center

Discusses a four-step instructional presentation in which the twin on the earth is demonstrated older than the twin aboard a spaceship on the basis of the relativistic Doppler effect. Concludes that both twins can meet again at the same place in space at the expense of time. (CC)

Hewitt, Paul G.

1973-01-01

230

Congenital Heart Diseases in Twin Pregnancies  

Microsoft Academic Search

Objective: To find connection between the type of congenital heart malformations and twin pregnancies. Method: Retrospective analysis of data of fetal cardiology database between 1 January 1996 and 30 November 2003. Results: In single pregnancies 455 and in twin pregnancies 31 severe congenital heart malformations were diagnosed prenatally. In monozygotic twin pregnancies 36% of heart malformations were pulmonary stenosis and

J. Hajdu; A. Beke; T. Marton; E. Hruby; B. Pete; Z. Papp

2006-01-01

231

Conjoined twins – the Cape Town experience  

Microsoft Academic Search

This paper records our experience in the management of 25 sets of conjoined twins seen over a 32 year period (1964?–?1996). The twins were classified into 14 complete and symmetrical sets and 11 incomplete or heteropagus. The 14 symmetrical sets included 9 thoracopagus, 2 ischiopagus, 1 craniopagus and 1 omphalopagus twins. In the incomplete heteropagus group there was 1 ischiopagus,

S. Cywes; A. J. W. Millar; H. Rode; R. A. Brown

1997-01-01

232

A Report of Dizygous Monochorionic Twins  

Microsoft Academic Search

fertilization. The twins also had blood chimerism (the presence of cells derived from more than one genetically distinct zygote); in both twins, there was a predominance of male-derived lymphocytes, and as a result, the initial findings of zygosity studies per- formed on DNA extracted from the blood were consistent with monozygosity. Subse- quent detailed investigation showed the twins to be

Vivienne L. Souter; Raj P. Kapur; Dale R. Nyholt; Kristen Skogerboe; David Myerson; Carl C. Ton; Kent E. Opheim; Thomas R. Easterling; Laurence E. Shields; Grant W. Montgomery; Ian A. Glass

2003-01-01

233

Growth and development in premature twins  

Microsoft Academic Search

A total of 476 infants (386 singletons and 90 twins) born before 32 weeks' gestation were studied to compare long term growth and development in twins and singletons. At 18 months, after adjusting for confounding social, obstetric, and neonatal factors, twins were not disadvantaged in their neurodevelopmental status, but were 1.6 cm shorter than singletons and had thicker triceps and

R Morley; T J Cole; R Powell; A Lucas

1989-01-01

234

Separated fraternal twins: Resemblance for cognitive abilities  

Microsoft Academic Search

Thirty-four pairs of Swedish fraternal twins separated in the first 10 years of life were administered 12 tests of cognitive abilities. The average age of the twins was 59 years. Nineteen pairs were separeted before the first year of life and 26 pairs (76%) were separated by the age of 5 years. Moderate positive twin correlations were found for all

N. L. Pedersen; G. E. McClearn; R. Plomin; L. Friberg

1985-01-01

235

On Teaching About Twins and Time  

ERIC Educational Resources Information Center

|Discusses a four-step instructional presentation in which the twin on the earth is demonstrated older than the twin aboard a spaceship on the basis of the relativistic Doppler effect. Concludes that both twins can meet again at the same place in space at the expense of time. (CC)|

Hewitt, Paul G.

1973-01-01

236

Research With Twins: The Concept of Emergenesis  

Microsoft Academic Search

Preliminaty findings from an on-going study of monozygotic twins reared apart (MZA) and data from a larger sample of twins reared together (MZT and DZT), indicate a surprisingly strong influence of genetic variation on aptitudes, psychophysiological characteristics, personality traits and even dimensions of atti- tude and interest. For some of these variables, MZT and MZA twins show high intra-class correlations

David T. Lykken

1982-01-01

237

A Twin Study of Adult Gambling Behavior  

Microsoft Academic Search

A twin study explored the possible genetic influences on gambling behavior. Male monozygotic (MZ) twins (n = 42) revealed significantly greater similarity on gambling frequency associated with “high-action” games than male dizygotic (DZ) twins (n = 50). The heritability estimates for involvement in these types of games among males were moderate and significant. All MZ versus DZ comparisons among males

Ken C. Winters; Timothy Rich

1998-01-01

238

Diagnosis, Pathophysiology, and Treatment of Chronic Twin-to-Twin Transfusion Syndrome  

Microsoft Academic Search

The discovery of a ‘stuck twin’ during an ultrasound examination has often been equated with twin-to-twin transfusion based to a great extent on postnatal confirmation of discordant fetal size and hemoglobin concentration. However, the diagnosis of twin-to-twin transfusion cannot be made with certainty after birth since virtually all monochorionic gestations have placental anastomoses and there are many causes of growth

Carl P. Weiner; Avi Ludomirski

1994-01-01

239

Commitment to X Inactivation Precedes the Twinning Event in Monochorionic MZ Twins  

Microsoft Academic Search

Summary To gain insight into the timing of twinning, we have examined a closely related event, X-chromosome inac- tivation, in female MZ twin pairs. X-inactivation pat- terns in peripheral blood and buccal mucosa were com- pared between monochorionic MZ (MC-MZ) and dichorionic MZ (DC-MZ) twins. Overall, the MC-MZ twins displayed highly similar X-inactivation patterns, whereas DC-MZ twins frequently differed in

Joanita Monteiro; Catherine Derom; Robert Vlietinck; Nina Kohn; Martin Lesser; Peter K. Gregersen

1998-01-01

240

Healthy weight - healthy blood pressure  

PubMed Central

World Hypertension Day is an initiative of the World Hypertension League. This year’s theme is “Healthy weight – healthy blood pressure”. According to the World Health Organization, more than one billion people worldwide are reported to be overweight and more than 300 million people are obese. Obesity is linked to hypertension, kidney diseases and other cardiovascular diseases. Through World Hypertension Day, the World Hypertension League, in partnership with national and international organizations, aims to raise the awareness of obesity and hypertension. Simple manoeuvres such as eating healthy, being physically active, and changing nutritional and dietary behaviours are recommended.

Chockalingam, Arun

2010-01-01

241

Twin-twin transfusion syndrome and twin anemia-polycythemia sequence in a monochorionic triamniotic pregnancy.  

PubMed

Twin-twin transfusion syndrome (TTTS) is an antenatal complication of monochorionic multiple gestations. There have been few studies exploring the role of laser photocoagulation or outcomes following treatment in monochorionic triplet pregnancies with TTTS. We present a case where TTTS and twin anemia-polycythemia sequence (TAPS) complicated a monochorionic triplet pregnancy. Following the laser photocoagulation to treat the TTTS between the triplets, an intra-uterine death occurred in one triplet and TAPS developed in the remaining two triplets. Intervention in this case resulted in a 2-week prolongation of pregnancy and a positive outcome for the remaining fetuses. This case and other published data reviewed in this article suggest that laser photocoagulation has a potential role for TTTS in monochorionic triplet pregnancies. PMID:23561046

Davidoff, Dahlia F; Dickinson, Jan E; Warner, Teresa; Pennell, Craig E

2013-04-08

242

Establishing a twin register in Sri Lanka.  

PubMed

Nearly all twin registers are based in developed countries and there is no twin register in the developing world. Our objectives were to initiate the process of establishing a nationwide twin register in Sri Lanka by starting a volunteer register first and working towards a population-based register. Regular newspaper advertisements, feature articles, radio talks, and television programmes were used to publicise a competition for twins, their parents/relatives and friends requesting them to participate by sending in details of twins. The competition ran from 28 March 1997 for a period of 3 months. It offered prizes for three winners selected by drawing lots. Advertisements highlighted the objective of the competition as establishing a twin register for future research and emphasised that informed consent would be obtained for individual research projects. Those who registered comprise 4602 twin pairs (same sex: male--1564, female--1885; different sex--1153), 80 sets of triplets (same sex: male--17, female--31; different sex--42) and two sets of quadruplets (different sex). The oldest twins, triplets, quadruplets are 85, 46, and 5 years old, respectively; 88.0% of twins are less than 30 years old. Although others have previously used media publicity to enrol twins in twin registers, we believe this to be the first time that twins have been enrolled through competition. We have more young twins, and our gender and zygosity proportions after applying Weinburg's rule do not match the proportions expected from a volunteer twin sample. Establishing a twin register for research purposes has proved possible in a developing country. PMID:11463139

Sumathipala, A; Fernando, D J; Siribaddana, S H; Abeysingha, M R; Jayasekare, R W; Dissanayake, V H; De Silva, N

2000-12-01

243

10. Photocopy of photograph showing the three Walker sisters ginning ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

10. Photocopy of photograph showing the three Walker sisters ginning cotton. Misses Hettie, Martha and Louisa are from left to right. The original photograph was taken on May 21, 1936 by Edouard E. Exline and is one of five photographs in the album, 'A Sketch of Mountain Life: Great Smoky Mountains National Park', compiled by Edouard E. Exline and C.S. Grossman. The album is on file at the Great Smoky Mountains National Park; the photograph number is III-A-HSE-9642. - Walker Family Farm (General views), Gatlinburg, Sevier County, TN

244

Beyond Heritability: Twin Studies in Behavioral Research  

PubMed Central

The heritability of human behavioral traits is now well established, due in large measure to classical twin studies. We see little need for further studies of the heritability of individual traits in behavioral science, but the twin study is far from having outlived its usefulness. The existence of pervasive familial influences on behavior means that selection bias is always a concern in any study of the causal effects of environmental circumstances. Twin samples continue to provide new opportunities to identify causal effects with appropriate genetic and shared environmental controls. We discuss environmental studies of discordant twin pairs and twin studies of genetic and environmental transactions in this context.

Johnson, Wendy; Turkheimer, Eric; Gottesman, Irving I.; Bouchard, Thomas J.

2010-01-01

245

Heteropagus twinning on back -- a case report.  

PubMed

Heteropagus twins, also called parasitic twins, are malformation of the foetus where the development of one twin is incomplete. They are attached most commonly to the lower chest and upper abdomen. We report a case of heteropagus twin, where the parasite possessed well-formed limb as well as blind ending intestine. It was attached to the back of the host by a broad pedicle. We take this opportunity to classify areas of confusion prevailing regarding twinning, foetus in foetu, teratoma and caudal duplication. PMID:22315854

Debnath, Bidyut; Biswas, Sumitra Kumar

2011-07-01

246

The sleep patterns of young twins.  

PubMed

Young children under three years are particularly prone to sleep disorders but the sleep patterns of twins have received little attention. This study considered the sleep patterns of 48 pairs of twins (96 children) aged 12-36 months compared with a control group of singleton children. The sleep patterns of twins were broadly similar to those of singletons. As other reports have indicated, the burdens carried by the parents of twins at night were heavier but not markedly so. Possible differences between normal and IVF twins in respect of sleep merit further consideration. PMID:12696301

Bartlet, Leslie; Witoonchart, Chatree

2003-01-01

247

Twin research, revisionism and metahistory  

Microsoft Academic Search

We understand metahistory as an approach that studies how histories within a particular discipline have been written and focus on insider scientists’ reconstructions of twin research. Using the concept of ethical-political affordances we suggest that such histories are based on a management of resources that prove to be beneficial for representing one’s own research traditions in a positive light. Instead

Thomas Teo; Laura C. Ball

2009-01-01

248

Alzheimer's disease in Finnish twins  

Microsoft Academic Search

SummaryBackground The genetics of Alzheimer's disease (AD) are obscure. Although most cases are sporadic half the patients with sporadic AD have a positive family history. The mode of genetic transmission and the role of environmental factors are unknown. The purpose of this study was to examine the contribution of genetic factors to the pathogenesis of AD in a twin cohort.Methods

I Räihä; T Rajala; L Sourander; J Kaprio; M Koskenvuo

1996-01-01

249

Twin tower gas fractionation apparatus  

Microsoft Academic Search

An apparatus for adsorptive fractionation of a gaseous mixture. The apparatus is a twin tower fractionator or dryer including a pair of sorbent beds. A filter and valve assembly directs a flow of the gaseous mixture from a source thereof to one of the beds for removing a gaseous component of said mixture while simultaneously directing a flow of purge

R. A. Null; L. C. laughlin; M. L. Goldberg

1985-01-01

250

A Twin Study of Alexithymia  

Microsoft Academic Search

Background: Factors contributing to the development of alexithymia and the nature of alexithymia’s relation with trait negative and positive affectivity are unclear. In this study, a twin approach was used to examine the degree of genetic and environmental contributions to the different facets of alexithymia, and the nature of their relations to trait negative and positive affectivity. Method: Forty-five monozygotic

Eve M. Valera; Howard Berenbaum

2001-01-01

251

Refractive errors in twin studies.  

PubMed

It is estimated that 1.6 billion people worldwide have myopia, a refractive error, and this number is expected to increase to approximately 2.5 billion by the year 2020. It is now well established that both the environment and genetics play a role in the development of myopia. However, the exact contribution of each of these components to myopia development has yet to be completely determined. Twin studies (classical twin model) are commonly used to determine the weighting of genetic and environmental components in disease. Over the last century, twin studies have investigated the heritability of refractive errors in different sample populations and have collectively supported a genetic basis to refractive errors. However, different sample populations and methods of data collection have produced a wide range of heritability estimates ranging from .5 to .9. This article will review those twin studies that have investigated refractive error, particularly myopia, as well as biometric measures linked to refractive error, to compare heritability estimates and methodology designs. PMID:16899164

Dirani, Mohamed; Chamberlain, Matthew; Garoufalis, Pam; Chen, Christine; Guymer, Robyn H; Baird, Paul N

2006-08-01

252

Do Twin Boundaries Always Strengthen Metal Nanowires?  

PubMed Central

It has been widely reported that twin boundaries strengthen nanowires regardless of their morphology—that is, the strength of nanowires goes up as twin spacing goes down. This article shows that twin boundaries do not always strengthen nanowires. Using classical molecular dynamics simulations, the authors show that whether twin boundaries strengthen nanowires depends on the necessary stress for dislocation nucleation, which in turn depends on surface morphologies. When nanowires are circular cylindrical, the necessary stress of dislocation nucleation is high and the presence of twin boundaries lowers this stress; twin boundaries soften nanowires. In contrast, when nanowires are square cylindrical, the necessary stress of dislocation nucleation is low, and a higher stress is required for dislocations to penetrate twin boundaries; they strengthen nanowires.

2009-01-01

253

Twinning in nanocrystalline fcc and bcc metals  

NASA Astrophysics Data System (ADS)

The deformation twinning in nanocrystalline (nc) face-centered cubic (fcc) metals, body-centered cubic (bcc) metals, and in nc Si is analyzed. The phenomenological approach is used to make a bridge between microscopical mechanisms of twin nucleation and macroscopical characteristics of twinning with different crystal structures and to calculate the grain size range of the twinning propensity, the requisite external stress for twinning propagation in nc polycrystals, and the grain size at which the slip begins to prevail over the twinning. The developed approach allows to derive analytical expressions and estimate lower and and upper limits of grain sizes at which a twinning propensity is occurred. Results of calculations for the nc fcc metals Al, Cu, Ni, Pd, Au, nc bcc metals Ta, Fe, Mo, W, Nb, and nc diamond-cubic Si are compared with the experimental data, otherwise predictions are made.

Boyko, Vladimir S.; Kezerashvili, Roman Ya.

2013-03-01

254

Sleeping Arrangements in Families with Twins  

PubMed Central

This paper describes home sleeping arrangements used by parents of twins and investigates whether room sharing (twins in the same room as parents) or cobedding (crib-sharing between twins) influences parental night time sleep duration or sleep quality. A secondary analysis of data obtained from a longitudinal study of sleep in 104 families with twins was undertaken. Over 65% of twins were cobedded at 4 weeks; this decreased to approximately 42% by 13 weeks of age. Approximately 64% of families practiced room sharing at 4 weeks, this decreased to approximately 40% by 13 weeks of age. Mothers and fathers who both room shared and cobedded their twins at 9 weeks of age were most likely to experience restricted sleep duration when compared to other sleeping arrangements. Results suggest that parents of twins may not be following the most recent AAP recommendations regarding safe infant sleep for multiple birth infants.

Damato, Elizabeth G.; Brubaker, Jennifer A.; Burant, Christopher

2012-01-01

255

Genome-Wide DNA Methylation and Gene Expression Analyses of Monozygotic Twins Discordant for Intelligence Levels  

PubMed Central

Human intelligence, as measured by intelligence quotient (IQ) tests, demonstrates one of the highest heritabilities among human quantitative traits. Nevertheless, studies to identify quantitative trait loci responsible for intelligence face challenges because of the small effect sizes of individual genes. Phenotypically discordant monozygotic (MZ) twins provide a feasible way to minimize the effects of irrelevant genetic and environmental factors, and should yield more interpretable results by finding epigenetic or gene expression differences between twins. Here we conducted array-based genome-wide DNA methylation and gene expression analyses using 17 pairs of healthy MZ twins discordant intelligently. ARHGAP18, related to Rho GTPase, was identified in pair-wise methylation status analysis and validated via direct bisulfite sequencing and quantitative RT-PCR. To perform expression profile analysis, gene set enrichment analysis (GSEA) between the groups of twins with higher IQ and their co-twins revealed up-regulated expression of several ribosome-related genes and DNA replication-related genes in the group with higher IQ. To focus more on individual pairs, we conducted pair-wise GSEA and leading edge analysis, which indicated up-regulated expression of several ion channel-related genes in twins with lower IQ. Our findings implied that these groups of genes may be related to IQ and should shed light on the mechanism underlying human intelligence.

Kobayashi, Kazuhiro; Shikishima, Chizuru; Cha, Pei-Chieng; Sese, Jun; Sugawara, Hiroko; Iwamoto, Kazuya; Kato, Tadafumi; Ando, Juko; Toda, Tatsushi

2012-01-01

256

fMRI and corpus callosum relationships in monozygotic twins discordant for handedness.  

PubMed

To further investigate brain structure and function in 26 handedness discordant monozygotic twin pairs (MzHd), MRI and behavioural assessments were carried out. These showed significant correlation between language-specific functional laterality in inferior and middle frontal gyri, and anterior corpus callosum. Previous studies of handedness discordant monozygotic twins failed to resolve the issue concerning handedness and hemispheric laterality for language due to methodological disparities. The results would be relevant to genetic theories as well as to brain structure:function explanations. MzHd twins underwent MRI and fMRI scanning as well as behavioural assessment of motor performance and cognition. There were significant differences on MRI and fMRI laterality measures, as well as a significant correlation between anterior callosal widths and functional laterality. LH twins showed higher frequencies of atypical functional laterality. There was no significant within-twin pair correlation on fMRI verbal laterality, nor did results show within-twin pair differences on verbal fluency or IQ. Implications for the field of laterality research pertain to frontal hemispheric equipotentiality for verbal processes in healthy individuals. In particular, there can be an apparent lack of cognitive 'cost' to atypical laterality. An fMRI verbal laterality index correlated significantly with corpus callosum widths near Broca's area. PMID:22527119

Gurd, J M; Cowell, P E; Lux, S; Rezai, R; Cherkas, L; Ebers, G C

2012-04-21

257

Genome-wide DNA methylation and gene expression analyses of monozygotic twins discordant for intelligence levels.  

PubMed

Human intelligence, as measured by intelligence quotient (IQ) tests, demonstrates one of the highest heritabilities among human quantitative traits. Nevertheless, studies to identify quantitative trait loci responsible for intelligence face challenges because of the small effect sizes of individual genes. Phenotypically discordant monozygotic (MZ) twins provide a feasible way to minimize the effects of irrelevant genetic and environmental factors, and should yield more interpretable results by finding epigenetic or gene expression differences between twins. Here we conducted array-based genome-wide DNA methylation and gene expression analyses using 17 pairs of healthy MZ twins discordant intelligently. ARHGAP18, related to Rho GTPase, was identified in pair-wise methylation status analysis and validated via direct bisulfite sequencing and quantitative RT-PCR. To perform expression profile analysis, gene set enrichment analysis (GSEA) between the groups of twins with higher IQ and their co-twins revealed up-regulated expression of several ribosome-related genes and DNA replication-related genes in the group with higher IQ. To focus more on individual pairs, we conducted pair-wise GSEA and leading edge analysis, which indicated up-regulated expression of several ion channel-related genes in twins with lower IQ. Our findings implied that these groups of genes may be related to IQ and should shed light on the mechanism underlying human intelligence. PMID:23082141

Yu, Chih-Chieh; Furukawa, Mari; Kobayashi, Kazuhiro; Shikishima, Chizuru; Cha, Pei-Chieng; Sese, Jun; Sugawara, Hiroko; Iwamoto, Kazuya; Kato, Tadafumi; Ando, Juko; Toda, Tatsushi

2012-10-17

258

Pregnancy risk among the younger sisters of pregnant and childbearing adolescents.  

PubMed

There is increasing evidence that younger sisters of childbearing teenagers are at increased risk for adolescent childbearing. We critically review this research and discuss three plausible theoretical explanations (social modeling, shared parenting influences, and shared societal risk) why the younger sisters of childbearing adolescents would themselves be at risk for teenage pregnancy. Considerations for preventive interventions aimed at the younger sisters of pregnant teenagers and directions for future research are discussed. PMID:1577959

East, P L; Felice, M E

1992-04-01

259

The Role of Sisters in Body Image Dissatisfaction and Disordered Eating  

Microsoft Academic Search

The Tripartite Influence Model (TIM) argues sociocultural agents affect body image dissatisfaction (BID) via the mediators\\u000a of social comparison and internalization. BID subsequently influences disordered eating. Forty-seven Australian sister pairs\\u000a (18–25 years) provided self-reports of perceived familial modeling and pressure by the sociocultural agents of mother, father\\u000a and sister, social comparison, internalization, BID, bulimic behaviors, and dietary restriction. Sisters were correlated

Kerri Coomber; Ross M. King

2008-01-01

260

Monozygotic Twins Discordant for Neurofibromatosis 1  

PubMed Central

We present monozygotic twins discordant for the autosomal dominant disorder neurofibromatosis type 1 (NF1). The affected twin was diagnosed with NF1 at age 12, based upon accepted clinical criteria for the disorder. Both twins were re-examined at ages 35 and 57, at which times the unaffected twin continued to show no clinical manifestations of NF1. Short tandem repeat marker (STR) genotyping at 10 loci on chromosome 17 and 10 additional loci dispersed across the genome revealed identical genotypes for the twins, confirming their monozygosity. The affected twin has three children, two of whom also have NF1, while the unaffected twin has two children, both unaffected. Using lymphoblastoid, fibroblast, and buccal cell samples collected from both twins and from other family members in three generations, we discovered a pathogenic nonsense mutation in exon 40 of the NF1 gene. This mutation was found in all cell samples from the affected twin and her affected daughter, and in lymphoblastoid and buccal cells but not fibroblasts from the unaffected twin. We also found a novel non-synonymous change in exon 16 of the NF1 gene that was transmitted from the unaffected mother to both twins and co-segregated with the pathogenic mutation in the ensuing generation. All cells from the twins were heterozygous for this apparent exon 16 polymorphism and for single nucleotide polymorphisms (SNPs) within 2.5kb flanking the site of the exon 40 nonsense mutation. This suggests that the NF1 gene of the unaffected twin differed in the respective lymphoblastoid cells and fibroblasts only at the mutation site itself, making post-zygotic mutation leading to mosaicism the most likely mechanism of phenotypic discordance. Although the unaffected twin is a mosaic, the distribution of the mutant allele among different cells and tissues appears to be insufficient to cause overt clinical manifestations of NF1.

Kaplan, Lee; Foster, Rosemary; Shen, Yiping; Parry, Dilys M.; McMaster, Mary L.; O'Leary, Melanie Collins; Gusella, James F.

2009-01-01

261

Influence of twin-twin transfusion syndrome on fetal cardiovascular structure and function: prospective case-control study of 136 monochorionic twin pregnancies  

PubMed Central

Objective: To test the hypothesis that identical twins show no inter-twin differences in cardiovascular structure or physiology in fetal life unless there has been twin-twin transfusion syndrome. Design: Unselected prospective case–control observational study of fetoplacental haemodynamics including echocardiography at a median of 24 (16.7 to 32.3) weeks, with postnatal confirmation of congenital heart disease or normality. Setting: Fetal medicine unit. Patients: 136 women with monochorionic diamniotic twin pregnancies, of which 47 fetal twin pairs (35%) had twin-twin transfusion syndrome. Results: There were no haemodynamic differences between the bigger fetus (twin 1) and the smaller co-twin (twin 2) in uncomplicated monochorionic diamniotic pairs. In twin-twin transfusion syndrome, recipient fetuses had increased aortic and pulmonary velocities compared with their donor co-twins (mean (SD): 0.73 (0.23) m/s and 0.63 (0.14) m/s), respectively, v 0.53 (0.16) m/s and 0.48 (0.10) m/s in donor twins; p = 0.003 (aortic) and < 0.0001 (pulmonary)), and also in comparison with twin 1 and twin 2. The overall prevalence of congenital heart disease was increased above that in singletons (3.8% v 0.56%; 6.9% in twin-twin transfusion v 2.3% in uncomplicated monochorionic diamniotic twins), with inter-twin discordance for defects. The prevalence in recipient twins was 11.9% (p = 0.014 v uncomplicated control twins). Conclusions: Fetuses with an identical genome but no circulatory imbalance have similar cardiovascular physiology but discordant phenotypic expression of congenital heart disease. The high prevalence of congenital heart disease in monochorionic diamniotic twins merits detailed fetal echocardiography.

Karatza, A A; Wolfenden, J L; Taylor, M J O; Wee, L; Fisk, N M; Gardiner, H M

2002-01-01

262

Healthy Learning.  

ERIC Educational Resources Information Center

Offers ten suggestions for schools and universities to help maintain a healthy indoor environment: proper flooring, sanitary washrooms, consistent maintenance, indoor air quality, preventing mold, daylighting, good acoustics, avoiding volatile organic compounds (VOCs), ergonomic furniture, and well-maintained roofs. (EV)

Kennedy, Mike

2003-01-01

263

Early prediction of severe twin-to-twin transfusion syndrome  

Microsoft Academic Search

there were 43 (15%) which developed severe TTS. The This extended series of 303 monochorionic twin pregnancies median fetal NT was 1.0 multiples of the median (MOM) examined at 10-14 weeks examines further the possible and NT was >95th centile in 47 (8.2%) fetuses and in at association of fetal NT in the early prediction of TTS. least one fetus

N. J. Sebire; A. Souka; H. Skentou; L. Geerts; K. H. Nicolaides

2000-01-01

264

Why the Healing Gods Are Twins  

PubMed Central

The association of twins with health-giving powers is widespread in mythology, folklore, and religion. The Ashvins of the Rig-Veda, the classical Dioscuri, and the early Christian saints Cosmos and Damian are among the many examples of twins divinely empowered in the area of health and fertility. A characteristic set of attributes of twins recurs in different mythologies of wide distribution. In addition to healing, divine twins are often empowered with the ability to revive the dead, increase the fertility of man, animals, and crops, influence the weather, predict the future, and insure victory in battle. In some traditional societies these special attributes are thought to extend to all of the twins and their parents in the tribe. Ancient and primitive societies supposed that the birth of twins was associated with divine influence, the mother having been visited or otherwise affected by supernatural powers. A frequent explanation was that twins were the result of superfetation, a divine impregnation occurring along with that by the lawful husband. The specific powers of divine twins appear to be a reflection of the particular form of origin of twins through divine interference with the fertilization process. The twins thus share some of the powers of the divine parent, particularly those pertaining to fertility. Their dual paternity and its inherent competition is related to their martial interests as well as their ability to resolve ambivalent or ambiguous situations and predict outcomes.

Hankoff, Leon D.

1977-01-01

265

Suicidal behavior in surviving co-twins.  

PubMed

Recent research has provided strong support for the existence of a familial risk for suicide, and efforts have been made to separate genetic from enviromental risk factors. Twin studies have played a major role in the identification of genetic factors, and the results indicate that the concordance rate for suicide is higher in identical than in fraternal twins (Baldessarini & Hennen, 2004). Moreover, Segal and Roy (1995) reported a significantly higher frequency of nonfatal suicidal attempts by monozygotic (MZ) than by dyzygotic (DZ) twins whose co-twins had committed suicide. However, doubts remain as to whether the increased risk of suicide in MZ twins is a response to the intense grief over the loss of a close relative, or whether a common genotype is associated with suicidal behavior. Sudden loss, which may carry a stigma in the case of a suicide, has been linked to increased persistent emotional stress and physiological changes (Epstein, 1993; Martin & Dean, 1993). A number of researchers have reported greater suicidal ideation among bereaved MZ twins as compared to DZ twins, suggesting that a loss due to suicide may increase the risk of suicidal behavior in the surviving co-twin (Segal & Bouchard, 1993; Segal & Roy, 1995; Segal et al., 1995). The aim of the present article is to address the issue of the intense grief experienced by twins after the co-twin suicide. PMID:17032544

Pompili, Maurizio; Galeandro, Piera Maria; Lester, David; Tatarelli, Roberto

2006-10-01

266

Deformation twinning: Influence of strain rate  

SciTech Connect

Twins in most crystal structures, including advanced materials such as intermetallics, form more readily as the temperature of deformation is decreased or the rate of deformation is increased. Both parameters lead to the suppression of thermally-activated dislocation processes which can result in stresses high enough to nucleate and grow deformation twins. Under high-strain rate or shock-loading/impact conditions deformation twinning is observed to be promoted even in high stacking fault energy FCC metals and alloys, composites, and ordered intermetallics which normally do not readily deform via twinning. Under such conditions and in particular under the extreme loading rates typical of shock wave deformation the competition between slip and deformation twinning can be examined in detail. In this paper, examples of deformation twinning in the intermetallics TiAl, Ti-48Al-lV and Ni{sub 3}A as well in the cermet Al-B{sub 4}C as a function of strain rate will be presented. Discussion includes: (1) the microstructural and experimental variables influencing twin formation in these systems and twinning topics related to high-strain-rate loading, (2) the high velocity of twin formation, and (3) the influence of deformation twinning on the constitutive response of advanced materials.

Gray, G.T. III

1993-11-01

267

Brain potentials and lateral dominance in identical twins  

Microsoft Academic Search

The data on bilateral differences in electro-encephalograms of identical twins indicate that these twins are more similar than unrelated children only when treated as a group. The recorded potentials of identical twins may differ in that there is a tendency for one twin to show bilateral differences which are the reverse of those found in the other twin. Also, in

E. T. Raney

1939-01-01

268

187. Photocopy of drawing, Twin Falls Canal Company, date unknown. ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

187. Photocopy of drawing, Twin Falls Canal Company, date unknown. TOPOGRAPHICAL MAP OF MILNER DAM LOCATION, TWIN FALLS COUNTY, MILNER, IDAHO; BLUEPRINT MAP. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

269

192. Photocopy of drawing, Twin Falls Canal Company, date unknown. ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

192. Photocopy of drawing, Twin Falls Canal Company, date unknown. TOPOGRAPHICAL MAP (DAM DRAWN IN), MILNER SITE, TWIN FALLS COUNTY, MILNER, IDAHO; RIGHT SIDE OF MAP (LEFT ON ID-15-183). - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

270

183. Photocopy of map (Twin Falls Canal Company). TOPOGRAPHICAL MAP ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

183. Photocopy of map (Twin Falls Canal Company). TOPOGRAPHICAL MAP OF MILNER DAM SITE, TWIN FALLS COUNTY, MILNER, IDAHO; MAP, LEFT SIDE ONLY. CROSS REFERENCE: ID-15-192. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

271

Evaluation of fetal lung maturity in diamniotic twins  

Microsoft Academic Search

Objective: This study was undertaken to evaluate the correspondence in fetal lung development between diamniotic twins. Study Design: Lecithin\\/sphingomyelin ratios were determined for amniotic fluid specimens collected from each sac in 58 diamniotic twin pregnancies. Results: Overall, the lecithin\\/sphingomyelin ratios of twin A and twin B and those of the larger and smaller twins of each pair were closely correlated

Neil S. Whitworth; Everett F. Magann; John C. Morrison

1999-01-01

272

Enhanced response to the induction of sister chromatid exchange by gamma radiation in neurofibromatosis  

SciTech Connect

The study included 8 unrelated patients with neurofibromatosis, and 10 unrelated normal and healthy persons as controls. Whole blood samples were divided into plastic T flasks and exposed at room temperature to gamma rays. The radiation dose was 36 rad/minute, and the doses delivered were 0, 75, 150 and 300 rad. The lymphocytes were cultured in (RPMI) 1640 tissue culture medium and autologous serum (20%). Phytohemagglutinin and bromodeoxyuridine (Brdu) (10 microM) were added at initiation of culture and harvesting was done 64 to 68 hours after culture initiation. Slides were coded, differential staining was done, and sister chromatid exchanges (SCEs) and aberrations (gaps, breaks, dicentrics, fragments and minutes) were counted. In the controls no significant increase in frequency of SCE has been found (P greater than 0.5). In the patients, the frequencies significantly increased with the increase of dose of irradiation (P less than 0.001). Furthermore, after irradiation, the incidence of gaps, breaks, and dicentrics were significantly increased in patients compared with controls. Moreover, the incidence increased with the increase in the dose of radiation. The results are discussed with a conclusion that the results add to the indication of a genetic predisposition to develop cancer in neurofibromatosis patients.

Hafez, M.; Abd el-Nabi, S.M.; el-Wehedi, G.; Al-Tonbary, Y.

1986-05-15

273

Molecular analysis of the gut microbiota of identical twins with Crohn's disease  

SciTech Connect

Increasing evidence suggests that a combination of host genetics and the composition of the gut microbiota are important for development of Crohn's disease (CD). Our aim was to study identical twins with CD to determine microbial factors independently of host genetics. Fecal samples were studied from 10 monozygotic twin pairs with CD (discordant n=6, concordant n=4) and 8 healthy twin pairs. DNA was extracted, 16S rRNA genes were PCR amplified and T-RFLP fingerprints generated using general bacterial and Bacteroides group specific primers. The microbial communities were also profiled based on their % G+C contents. Bacteroides 16S rRNA genes were cloned and sequenced from a subset of the samples. The bacterial diversity in each sample and similarity indices between samples were estimated based on the T-RFLP data using a combination of statistical approaches. Healthy individuals had a significantly higher bacterial diversity compared to individuals with CD. The fecal microbial communities were more similar between healthy twins than between twins with CD, especially when these were discordant for the disease. The microbial community profiles of individuals with ileal CD were significantly different from healthy individuals and those with colonic CD. Also, CD individuals had a lower relative abundance of B. uniformis and higher relative abundances of B. ovatus and B. vulgatus. Our results suggest that genetics and/or environmental exposure during childhood in part determine the gut microbial composition. However, CD is associated with dramatic changes in the gut microbiota and this was particularly evident for individuals with ileal CD.

Jansson, Janet; Dicksved, Johan; Halfvarson, Jonas; Rosenquist, Magnus; Jarnerot, Gunnar; Tysk, Curt; Apajalahti, Juha; Engstrand, Lars; Jansson, Janet K.

2008-03-14

274

DNA damage response in monozygotic twins discordant for smoking habits.  

PubMed

Previous studies in twins indicate that non-shared environment, beyond genetic factors, contributes substantially to individual variation in mutagen sensitivity; however, the role of specific causative factors (e.g. tobacco smoke, diet) was not elucidated. In this investigation, a population of 22 couples of monozygotic twins with discordant smoking habits was selected with the aim of evaluating the influence of tobacco smoke on individual response to DNA damage. The study design virtually eliminated the contribution of genetic heterogeneity to the intra-pair variation in DNA damage response, and thus any difference in the end-points investigated could directly be attributed to the non-shared environment experienced by co-twins, which included as main factor cigarette smoke exposure. Peripheral lymphocytes of study subjects were challenged ex vivo with ?-rays, and the induction, processing, fixation of DNA damage evaluated through multiple approaches. Folate status of study subjects was considered significant covariate since it is affected by smoking habits and can influence radiosensitivity. Similar responses were elicited by ?-rays in co-twins for all the end-points analysed, despite their discordant smoking habits. Folate status did not modify DNA damage response, even though a combined effect of smoking habits, low-plasma folic acid level, and ionising radiation was observed on apoptosis. A possible modulation of DNA damage response by duration and intensity of tobacco smoke exposure was suggested by Comet assay and micronucleus data, but the effect was quantitatively limited. Overall, the results obtained indicate that differences in smoking habits do not contribute to a large extent to inter-individual variability in the response to radiation-induced DNA damage observed in healthy human populations. PMID:23132286

Marcon, Francesca; Carotti, Daniela; Andreoli, Cristina; Siniscalchi, Ester; Leopardi, Paola; Caiola, Stefania; Biffoni, Mauro; Zijno, Andrea; Medda, Emanuela; Nisticò, Lorenza; Rossi, Sabrina; Crebelli, Riccardo

2012-11-06

275

Congenital malaria in newborn twins.  

PubMed

A 28-year-old woman (G2P1A), with 36 weeks gestation, reported to a health facility in Sunyani on 22(nd) February 2009 with history of labour pains, without fever. She was reported to have taken sulphadoxine-pyrimethamine for malaria prophylaxis during the pregnancy but did not use insecticide-treated net. She delivered twins on the same day. The mother and the twins developed fever on the same day. A laboratory investigation on the three of them was positive for malaria parasites. The three were successfully treated with quinine. Congenital malaria is real and it is therefore recommended that babies born to mothers with malaria should be screened for congenital malaria. PMID:23661831

Opare, D A

2012-09-01

276

Twin tower gas fractionation apparatus  

SciTech Connect

An apparatus for adsorptive fractionation of a gaseous mixture. The apparatus is a twin tower fractionator or dryer including a pair of sorbent beds. A filter and valve assembly directs a flow of the gaseous mixture from a source thereof to one of the beds for removing a gaseous component of said mixture while simultaneously directing a flow of purge gas through the outer of said beds for stripping the adsorbed gas component therefrom and regenerating the bed. Microprocessor controlled valves control the flow of gases to and from said beds. The towers and associated manifolds are twin bore extrusion prism shaped of heat conductive material. The parallel bores extend axially longitudinally through the tower extrusion with each bore adapted to contain a sorbent bed or bed cartridge. conductivity probes are used to sense the moisture or adsorbed component front in the sorbent bed.

Null, R. A.; laughlin, L. C.; Goldberg, M. L.

1985-12-17

277

The TWINS Science Data System after the launch of TWINS 1  

NASA Astrophysics Data System (ADS)

The Two Wide-angle Imaging Neutral-atom Spectrometers (TWINS) 1 satellite is in orbit and science data are expected to commence in the near future. TWINS-1 comprises half of the TWINS stereoscopic neutral atom imaging system that will advance our knowledge of the Earth's ring current. To support the expected data return, we have developed a Science Data System (SDS) for the TWINS mission. The TWINS SDS is an IDL- and Java- driven data interface that operates primarily via a web browser, and has as its spine an SQL-queryable database. Through this interface, TWINS science data will be provided to the TWINS team, the space science community, and the public. In this paper we present the current and future capabilities of the TWINS SDS, as well as how the SDS fits into virtual observatory infrastructure.

Goldstein, J.; Valek, P.; Skoug, R.; Delapp, D.; Redfern, J.; Carruth, B.; McComas, D.

2007-05-01

278

Einstein and the twin paradox  

NASA Astrophysics Data System (ADS)

Einstein was the first to discuss and resolve the 'twin paradox', which in 1905 he did not consider paradoxical and treated as a consequence of lack of simultaneity. He maintained this view until at least 1914. However, in 1918 Einstein brought forward arguments about accelerated frames of reference that tended to overshadow his initial resolution. His earlier arguments were gradually rediscovered during the subsequent controversy about this 'paradox'.

Pesic, Peter

2003-11-01

279

Blastocyst transfer and monozygotic twinning  

Microsoft Academic Search

Objective: To report two cases of monozygotic twinning after IVF-blastocyst transfer.Design: Case report.Setting: Private practice in an assisted reproductive technology clinic.Patient(s): Two women treated with IVF-ET at the blastocyst stage.Intervention(s): Pituitary down-regulation with luteal leuprolide acetate, ovulation induction with gonadotropins, IVF, sequential culture, blastocyst transfer, and P for luteal support.Main Outcome Measure(s): Levels of hCG, pelvic ultrasound examination, amniocentesis, obstetric

Braulio Peramo; Elisabetta Ricciarelli; Jorge M. Cuadros-Fernández; Eva Huguet; Eleuterio Rodrigo Hernández

1999-01-01

280

Fullerton Virtual Twin Study: an update.  

PubMed

Virtual twins (VTs) are same-age unrelated siblings reared together from early infancy. These unique sibling sets replicate twinship, but without the genetic link. The first VT pair was identified and studied at the University of Minnesota in 1990, launching the development of the Fullerton Virtual Twin Study at California State University, Fullerton (CSUF) in 1991. The registry currently includes 151 pairs, mostly children, with new pairs identified on a continuous basis. Research with VTs includes studies of general intelligence, body size, interpersonal trust, social coordination, social networks, and parenting. In some cases, VTs have been studied in conjunction with pairs of monozygotic twins, dizygotic twins, full siblings, and friends as part of TAPS (Twins, Adoptees, Peers and Siblings), a collaborative project conducted between CSUF and the University of San Francisco, 2002-2006. VTs will also serve as a comparison group for epigenetic analyses of young Chinese twins reared apart and together. PMID:23218132

Segal, Nancy L; McGuire, Shirley A; Graham, Jamie L; Stohs, Joanne Hoven

2012-12-07

281

Advanced characterization of twins using automated EBSD  

SciTech Connect

This poster describes resuns obtained using an automated, crystallographically-based technique for twin identification. The technique is based on the automated EBSD. The key features of the analysis are identification of potential twin boundaries by their misorientation character, identification of the distinct boundary planes among the symmetrically equiwlent candidates. and validation of these boundaries through comparison with the boundary and twin plane traces in the sample cross section. Results on the application of this technique to deformation twins in zirconium are analyzed for the effect of twin type and amount and sense of uniaxial deformation. The accumulation of strain tends to increase the misorientation deviation at least to the degree of the trace deviation compared with recrystalllzation twins in nickel.

Wright, S. I. (Stuart I.); Bingert, J. F. (John F.); Mason, T. A. (Thomas A.); Larsen, Ryan J.

2002-01-01

282

Medical demography and epidemiology: dizygotic twins.  

PubMed

Demography is the statistical study of populations, epidemiology of health of populations. Fascinating challenges for future research, shared by epidemiology and demography, are to be found in the human life course, how the life course is transmitted over generations, how the healthy life is shaped by dynamics within the life course and how the life course is affected by the social and economic environment. The life course begins when two future parents meet. Then social disadvantage or privilege is beginning and diverse rates of ageing are being fixed. Health in utero and at young age will co-determine health at middle and old age, among others mediated by a greater intelligence and a better education. Particularly better education compresses cognitive disability at the end of life, building cognitive reserves that increase brain plasticity and enhance resistance to damage. While with extended life spans may come extended life spans with disability, the twin demography and epidemiology may show how to lighten the burden of senescence at the end of life. PMID:19291415

Bonneux, Luc Gustaaf Antoon

2009-03-17

283

Narcolepsy with cataplexy mimicry: the strange case of two sisters.  

PubMed

We report on two sisters, 17 and 12 years of age, with clinical features suggesting narcolepsy with cataplexy (NC): daytime sleepiness, spontaneous and emotionally triggered sudden falls to the ground, and overweight/obesity. MSLT showed borderline sleep latency, with 1 and 0 sleep onset REM periods. HLA typing disclosed the DQB1*0602 allele. Video-polygraphy of the spells ruled out NC diagnosis by demonstrating their easy elicitation by suggestion, with wake EEG, electromyographic persistence of muscle tone, and stable presence of tendon reflexes (i.e., pseudo-cataplexy), together with normal cerebrospinal hypocretin-1 levels. Our cases emphasize the need of a clear depiction of cataplexy pattern at the different ages, the usefulness of examining ictal neurophysiology, and collecting all available disease markers in ambiguous cases. PMID:23772196

Pizza, Fabio; Vandi, Stefano; Poli, Francesca; Moghadam, Keivan Kaveh; Franceschini, Christian; Bellucci, Claudia; Cipolli, Carlo; Ingravallo, Francesca; Natalini, Giuliana; Mignot, Emmanuel; Plazzi, Giuseppe

2013-06-15

284

Japanese sisters associated with pseudohomozygous familial hypercholesterolemia and sitosterolemia.  

PubMed

Pseudohomozygous familial hypercholesterolemia is a rare condition of unknown etiology. Sitosterolemia is a rare autosomal recessively inherited disorder that is characterized by premature coronary artery disease, cutaneous xanthomas, and increased plasma plant sterols and 5alpha-stanols. Only a few cases of both sitosterolemia and pseudohomozygous familial hypercholesterolemia have been reported. In this study, we report two sisters with both conditions. With a low-cholesterol diet (< 250 mg/day), serum cholesterol concentration decreased rapidly to an almost normal level and cutaneous xanthomas gradually regressed and finally disappeared; however, plant sterol levels did not change during the period. Plant sterols should be measured in patients considered to have pseudohomozygous familial hypercholesterolemia. The two conditions in this family may have been the results of a single gene mutation. The findings also indicate that low cholesterol diet therapy is effective for the treatment of hypercholesterolemia but not of sitosterolemia in this family. PMID:11425042

Yoshida, A; Naito, M; Miyazaki, K

2000-01-01

285

Segregating Sister Genomes: The Molecular Biology of Chromosome Separation  

NSDL National Science Digital Library

During cell division, each daughter cell inherits one copy of every chromosome. Accurate transmission of chromosomes requires that the sister DNA molecules created during DNA replication are disentangled and then pulled to opposite poles of the cell before division. Defects in chromosome segregation produce cells that are aneuploid (containing an abnormal number of chromosomes)âÂÂa situation that can have dire consequences. Aneuploidy is a leading cause of spontaneous miscarriages in humans and is also a hallmark of many human cancer cells. Recent work with yeast, Xenopus, and other model systems has provided new information about the proteins that control chromosome segregation during cell division and how the activities of these proteins are coordinated with the cell cycle.

Kim Nasmyth (IMP;)

2002-07-26

286

Coenzyme Q-responsive Leigh's encephalopathy in two sisters.  

PubMed

A 31-year-old woman had encephalopathy, growth retardation, infantilism, ataxia, deafness, lactic acidosis, and increased signals of caudate and putamen on brain magnetic resonance imaging. Muscle biochemistry showed succinate:cytochrome c oxidoreductase (complex II-III) deficiency. Both clinical and biochemical abnormalities improved remarkably with coenzyme Q10 supplementation. Clinically, when taking 300mg coenzyme Q10 per day, she resumed walking, gained weight, underwent puberty, and grew 20cm between 24 and 29 years of age. Coenzyme Q10 was markedly decreased in cerebrospinal fluid, muscle, lymphoblasts, and fibroblasts, suggesting the diagnosis of primary coenzyme Q10 deficiency. An older sister has similar clinical course and biochemical abnormalities. These findings suggest that coenzyme Q10 deficiency can present as adult Leigh's syndrome. PMID:12447928

Van Maldergem, Lionel; Trijbels, Frans; DiMauro, Salvatore; Sindelar, Pavel J; Musumeci, Olimpia; Janssen, Antoon; Delberghe, Xavier; Martin, Jean-Jacques; Gillerot, Yves

2002-12-01

287

Evaluation of the Eugene, Oregon Big Brother-Big Sister Program.  

ERIC Educational Resources Information Center

This document reports on parent and elementary pupil expectations regarding participation in a Big Brother-Big Sister type program. The parents and students included were all new to the program and experiencing the relationship with a Big Brother or Sister for the first time. In the program a community volunteer befriended a youngster at the…

Glass, Diane L.

288

Women and Sisters: The Antislavery Feminists in American Culture \\/ Book Review  

Microsoft Academic Search

Jean Fagan Yellin's Women and Sisters: The Antislavery Feminists in American Culture, on the iconography of the women's abolitionist movement, is a brilliant example of interdisciplinary thought and study. Crossing the boundaries of history, feminist theory, African American studies, and literary analysis, Yellin illuminates the complex intersections of art and politics in American life. Women and Sisters traces the history

Maureen T. Reddy

1996-01-01

289

Differential silver carbonate staining of sister chromatids in BrdU-substituted chromosomes  

Microsoft Academic Search

Differential staining of sister chromatids in BrdU-substituted human chromosomes is demonstrated by an ammoniacal silver carbonate procedure. With this method the chromosomes exhibit a subchromatid structure. Because proteolytic treatment indicated that the silver carbonate binds the chromosome proteins, changes of these components may be inferred in the BrdU-substituted chromosomes. Sister chromatid exchanges could be identified.

V. J. Goyanes

1978-01-01

290

Three Sisters with Chiari I Malformation with and without Associated Syringomyelia  

Microsoft Academic Search

Two daughters of non-consanguineous Ashkenazi Jewish parentage presented with occipital headaches in the second decade of life. Each had a symptomatic Chiari I malformation (CMI) and a large cervicothoracic syrinx. A third sister was diagnosed as having CMI without syrinx after MR screening of first-degree relatives. A fourth (the eldest) sister was asymptomatic and did not have CMI or syrinx.

James D. Weisfeld-Adams; Michael R. Carter; Marcus J. Likeman; Julia Rankin

2007-01-01

291

20 CFR 725.223 - Duration of entitlement; parent, brother, or sister.  

Code of Federal Regulations, 2013 CFR

...or sister. (a) A parent, sister, or brother...month for which such parent is entitled to benefits is the month in which the parent dies. (c) The...the following events first occurs: (1) The...2)(ii)) at that time; (4) If the...

2013-04-01

292

Brothers and sisters: a source of support for children in school?  

Microsoft Academic Search

Whilst UK schools move towards U.S ‘big brother’ style mentoring systems for children, are actual brothers and sisters becoming an invisible source of support to deal with bullying in everyday life? This paper reports on research with children aged 7–13 about their experiences and understandings of their relationships with their brothers and sisters, both at home and at school. Some

Lucy Hadfield; Rosalind Edwards; Melanie Mauthner

2006-01-01

293

Youths' Caretaking of Their Adolescent Sisters' Children: Results from Two Longitudinal Studies  

ERIC Educational Resources Information Center

|The extent and experiences of youths' caretaking of their adolescent sisters' children have been assessed in two longitudinal studies. The first study examines the caretaking patterns of 132 Latino and African American youth during middle and late adolescence. The second study involves 110 Latino youth whose teenage sister has recently given…

East, Patricia L.; Weisner, Thomas S.; Slonim, Ashley

2009-01-01

294

Genes Involved in Sister Chromatid Separation and Segregation in the Budding Yeast Saccharomyces cerevisiae  

Microsoft Academic Search

Accurate chromosome segregation requires the precise coordination of events during the cell cycle. Replicated sister chromatids are held together while they are properly attached to and aligned by the mitotic spindle at metaphase. At anaphase, the links between sisters must be promptly dissolved to allow the mitotic spindle to rapidly separate them to opposite poles. To isolate genes involved in

Sue Biggins; Needhi Bhalla; Amy Chang; Dana L. Smith; Andrew W. Murray

295

Long-term outcome in twin-twin transfusion syndrome treated with serial aggressive amnioreduction  

Microsoft Academic Search

Objective: The purpose of this study was to determine long-term outcomes among pregnancies complicated by twin-twin transfusion syndrome and treated in a tertiary center with serial aggressive amnioreduction. Study Design: Thirty-three pregnancies with a diagnosis of twin-twin transfusion syndrome were treated with ?1 amnioreduction. The perinatal outcome was assessed according to 15 parameters, whereas the main outcome at age ?2

Giancarlo Mari; Laura Detti; Utku Oz; Alfred Z. Abuhamad

2000-01-01

296

The Basic and Clinical Science of Twin–Twin Transfusion Syndrome  

Microsoft Academic Search

Twin–twin transfusion syndrome (TTTS) is a fascinating condition in which fetuses of identical genotype adopt discordant cardiovascular phenotypes, secondary to unbalanced placental inter-twin transfusion. Flow along the primary units of inter-twin transfusion, unidirectional arteriovenous anastomoses, can be as high as litres\\/day each, and TTTS develops when the placenta has insufficient compensatory counter-transfusional anastomoses. The initial phenotype reflects dysvolaemia, with added

N. M. Fisk; G. J. Duncombe; M. H. F. Sullivan

2009-01-01

297

Prediction of the maneuverability of a large container ship with twin propellers and twin rudders  

Microsoft Academic Search

The maneuvering characteristics of a large container ship with twin propellers and twin rudders were investigated using the\\u000a horizontal planar motion mechanism (HPMM) test and computer simulation. A mathematical model for maneuvering motion with four\\u000a degrees of freedom (DOF) for twin-propeller and twin-rudder systems was developed and included the effects of roll motion.\\u000a To obtain the roll-coupling hydrodynamic coefficients of

Yeon-Gyu Kim; Sun-Young Kim; Hyoung-Tae Kim; Seok-Won Lee; Byeong-Seok Yu

2007-01-01

298

Similarities in Drinking Behavior of Twin’s Friends: Moderation of Heritability of Alcohol Use  

Microsoft Academic Search

Previous research has indicated that friends’ drinking may influence alcohol use in adolescents and young adults. We explored\\u000a whether similarities in the drinking behavior of friends of twins influence the genetic architecture of alcohol use in adolescence\\u000a and young adulthood. Survey data from The Netherlands Twin Register were available for 1,526 twin pairs aged 16–25 years.\\u000a We categorized the twin pairs

Evelien A. P. Poelen; Rutger C. M. E. Engels; Ron H. J. Scholte; Dorret I. Boomsma; Gonneke Willemsen

2009-01-01

299

Australian Twin Registry: 30 years of progress.  

PubMed

The Australian Twin Registry (ATR) is a national volunteer resource of twin pairs and higher-order multiples willing to consider participating in health, medical, and scientific research. The vision of the ATR is 'to realize the full potential of research involving twins to improve the health and well-being of all Australians'. The ATR has been funded continuously by the National Health and Medical Council for more than 30 years. Its core functions entail the recruitment and retention of twin members, the maintenance of an up-to-date database containing members' contact details and baseline information, and the promotion and provision of open access to researchers from all institutes in Australia, and their collaborators, in a fair and equitable manner. The ATR is administered by The University of Melbourne, which acts as custodian. Since the late 1970s the ATR has enrolled more than 40,000 twin pairs of all zygosities and facilitated more than 500 studies that have produced at least 700 peer-reviewed publications from classical twin studies, co-twin control studies, within-pair comparisons, twin family studies, longitudinal twin studies, randomized controlled trials, and epigenetics studies, as well as studies of issues specific to twins. New initiatives include: a Health and Life Style Questionnaire; data collection, management, and archiving using a secure online software program (The Ark); and the International Network of Twin Registries. The ATR's expertise and 30 years of experience in providing services to national and international twin studies has made it an important resource for research across a broad range of disciplines. PMID:23200298

Hopper, John L; Foley, Debra L; White, Paul A; Pollaers, Vincent

2012-12-03

300

Conjoined Twins, Embodied Personhood, and Surgical Separation  

Microsoft Academic Search

The medical treatment of conjoined twins presents a compelling example of the need for non-idealizing approaches to ethical\\u000a decision-making. Since surgical separation often results in the death of one or both twins, the question whether separation\\u000a is justified is controversial. I argue that the debate remains unsettled because of insufficient attention to the actual metaphysical\\u000a status of conjoined twins.\\u000a \\u000a Until

Christine Overall

301

Deformation twinning: Influence of strain rate  

Microsoft Academic Search

Twins in most crystal structures, including advanced materials such as intermetallics, form more readily as the temperature of deformation is decreased or the rate of deformation is increased. Both parameters lead to the suppression of thermally-activated dislocation processes which can result in stresses high enough to nucleate and grow deformation twins. Under high-strain rate or shock-loading\\/impact conditions deformation twinning is

Gray

1993-01-01

302

Anaesthesia for the separation of conjoined twins  

PubMed Central

Thoraco-omphalopagus is one of the most common type of conjoint twins accounting for 74% cases of conjoint twins. We report the anaesthetic management for successful separation of thoraco-omphalopagus conjoint twins, both of them surviving till date. We highlight the responsibility of anaesthesia team in anaesthetising the two individual patients simultaneously, need of careful monitoring and anticipation of complications like massive blood loss, hypotension, hypokalemia, hypoxia and hypercabia. Detailed description of successful management is reported.

Lalwani, Jaya; Dubey, KP; Shah, Pratibha

2011-01-01

303

A twin study of personality disorders  

Microsoft Academic Search

No twin study has previously investigated the whole range of personality disorders (PDs) recorded by interviews. Based on twin and patient registries, 92 monozygotic (MZ) and 129 dizygotic (DZ) twin pairs were interviewed with the Structured Clinical Interview for DSM-III-R Personality Disorders (SCID-II). Observed prevalence rates from a normal population study of more than 2,000 individuals were used in combination

Svenn Torgersen; Sissel Lygren; Per Anders Øien; Ingunn Skre; Sidsel Onstad; Jack Edvardsen; Kristian Tambs; Einar Kringlen

2000-01-01

304

Dementia in Swedish Twins: Predicting Incident Cases  

Microsoft Academic Search

Thirty same-sex twin pairs were identified in which both members were assessed at baseline and one twin subsequently developed\\u000a dementia, at least 3 years subsequent to the baseline measurement, while the partner remained cognitively intact for at least\\u000a three additional years. Eighteen of the 30 cases were diagnosed with Alzheimer’s disease. Baseline assessments, conducted\\u000a when twins’ average age was 70.6 (SD = 6.8),

Margaret Gatz; Chandra A. Reynolds; Deborah Finkel; Nancy L. Pedersen; Ellen Walters

2010-01-01

305

Multiple regression analysis of twin data  

Microsoft Academic Search

A multiple regression model for the analysis of twin data is described in which a cotwin's score is predicted from a proband's score and the coefficient of relationship (R=1.0 and 0.5 for identical and fraternal twin pairs, respectively). This model is especially appropriate for the analysis of data on twins in which one member of each pair has been selected

J. C. DeFries; David W. Fulker

1985-01-01

306

A Computational Discriminability Analysis on Twin Fingerprints  

Microsoft Academic Search

Sharing similar genetic traits makes the investigation of twins an important study in forensics and biometrics. Fingerprints\\u000a are one of the most commonly found types of forensic evidence. The similarity between twins’ prints is critical establish\\u000a to the reliability of fingerprint identification. We present a quantitative analysis of the discriminability of twin fingerprints\\u000a on a new data set (227 pairs

Yu Liu; Sargur N. Srihari

2009-01-01

307

Management of perinatal loss of a twin.  

PubMed Central

The death of a twin during pregnancy or around birth gives rise to a bewildering confusion of thoughts and feelings that can impede mourning and disturb the bereaved mother's care of a surviving twin. Every effort should be made to give the parents and siblings an experience of the dead baby. Photographs especially can reduce confusion and assist reality testing and thus facilitate the grieving process and improve the care of the surviving twin.

Lewis, E.; Bryan, E. M.

1988-01-01

308

Guidance after twin and singleton neonatal death.  

PubMed Central

A study was made to determine whether parents whose newborn twin (n = 72) had died differed from bereaved singleton parents (n = 70) concerning their satisfaction with professional guidance and care. Most parents felt supported by hospital staff, but the twin parents had fewer avenues of available support, especially after their baby's death. The twin parents' situation requires special attention because they have specific needs that are not always addressed by the current range of available support services.

de Kleine, M.; Cuisinier, M.; Kollee, L.; Bethlehem, G.; de Graauw, K.

1995-01-01

309

Unusual presentation of two Chinese phenylketonuria sisters who were misdiagnosed for years.  

PubMed

Significant developmental delay was first noticed when both sisters were in their third year of life. However, no biochemical disorders were found through the routine biochemical tests, including liver and kidney function, lipoprotein, urine and blood cell count analysis. Progressively, both sisters exhibited odd behaviour, accompanied by personality changes and altered sleep rhythm and then were diagnosed as attention deficit hyperactivity disorder. In the eighth year, the younger sister began to take risperidone due to a presumed psychiatric disorder. Four months before attending our hospital, both sisters were diagnosed by MRI as having hereditary leukodystrophy. Nerve-nurturing treatment was tried, but without good outcome. They were then referred to our hospital for further consultation. After systematic examinations, it was confirmed that both the sisters were suffering from phenylketonuria. The symptoms were alleviated after dietary restriction of phenylalanine and symptomatic treatment. PMID:24068375

Liu, Xiaomei; Guo, Hui; Dahal, Mahesh; Shi, Bingyin

2013-09-24

310

Having a Brother or Sister with Down Syndrome: Perspectives from Siblings  

PubMed Central

This study asks brothers and sisters about their feelings and perceptions toward their sibling with Down syndrome. We analyzed valid and reliable surveys from 822 brothers and sisters whose families were on the mailing lists of six non-profit Down syndrome organizations around the country. More than 96% of brothers/sisters that responded to the survey indicated that they had affection toward their sibling with Down syndrome; and 94% of older siblings expressed feelings of pride. Less than 10% felt embarrassed, and less than 5% expressed a desire to trade their sibling in for another brother or sister without Down syndrome. Among older siblings, 88% felt that they were better people because of their siblings with Down syndrome, and more than 90% plan to remain involved in their sibling’s lives as they become adults. The vast majority of brothers and sisters describe their relationship with their sibling with Down syndrome as positive and enriching.

Skotko, Brian G.; Levine, Susan P.; Goldstein, Richard

2012-01-01

311

Discordance in nuchal translucency thickness in the prediction of severe twin-to-twin transfusion syndrome  

Microsoft Academic Search

Objective To examine in monochorionic pregnancies the possible value of intertwin discordance in nuchal translucency (NT) thickness in the prediction of early fetal death or severe twin-twin transfusion syndrome (TTTS). Methods In 512 monochorionic twin pregnancies NT was measured at 11 to 13 + 6 weeks' gestation and regression analysis was used to determine the significance of the association between

K. O. Kagan; A. Gazzoni; G. Sepulveda-Gonzalez; A. Sotiriadis; K. H. Nicolaides

2007-01-01

312

Chinese Twin Children Reared Apart and Reunited: First Prospective Study of Co-Twin Reunions  

Microsoft Academic Search

China's one-child policy led to the abandonment of tens of thousands of infants. Included among these children were twins who were adopted and reared separately. Since 2006, 10 reunited twin sets participated in the first prospective study of twins reared apart. This exploratory study reports a qualitative analysis of the children's reactions to their first meeting with, and departure from,

Nancy L. Segal; Joanne Hoven Stohs; Kara Evans

2011-01-01

313

Self-replicating twins in nanowires.  

PubMed

Based on molecular-dynamics simulations validated with quantum-mechanical calculations, we predict that (111) twin planes in a [111]-oriented GaAs nanowire attain attractive interactions mediated by surface strain. This gives rise to a self-replication mechanism that continuously generates a twin superlattice in a nanowire during growth. We demonstrate significant implications of the twin-twin interaction for the electronic, mechanical, and chemical properties of nanowires. These unique properties suggest potential applications such as catalysts for solar fuel production and nanoscale mechanical dampers. PMID:24073636

Yuan, Zaoshi; Nakano, Aiichiro

2013-10-01

314

Twinning modulation in ZnSe nanowires  

NASA Astrophysics Data System (ADS)

ZnSe nanowires were grown on Si substrates by Au-catalyzed vapour phase growth at 725 °C. A detailed structural and microstructural investigation has been carried out using electron diffraction and high-resolution transmission electron microscopy (HRTEM). Modulated twins have been observed along the nanowire axial direction along the entire length of the nanowires. Faceting has been observed on the side surfaces of the wires with a larger twinning periodicity. The formation mechanism of these twinning-modulated nanowires is discussed. The optical properties are correlated with the microstructure of the nanowires. These twinning-modulated ZnSe nanowires might have great potential as building blocks for optoelectronic nanodevices.

Wang, Y. Q.; Philipose, U.; Xu, T.; Ruda, H. E.; Kavanagh, K. L.

2007-03-01

315

Thoracopagus Conjoined Twins: A Case Report  

PubMed Central

Objective. Conjoined twin is a rarely seen congenital anomaly together with severe mortality and morbidity. The more common types of conjoined twins include the thoracopagus type, where the fusion is anterior, at the chest, and involves the heart. We are reporting one case of conjoined thoracopagus twins diagnosed by ultrasonography at 11 weeks. Case Report. In a multigravid pregnant woman who has been admitted to our clinic with a diagnosis of conjoined twins, thoracopagus, by ultrasonography at an 11-week gestation, termination of the pregnancy was performed. Conclusion. Making an early diagnosis with ultrasonographic examination gives the parents a chance to elect pregnancy termination.

Osmanagaoglu, Mehmet A.; Aran, Turhan; Guven, Suleyman; Kart, Cavit; Ozdemir, Ozgur; Bozkaya, Hasan

2011-01-01

316

Common plankton of Twin Lakes, Colorado  

SciTech Connect

A series of studies is being performed to evaluate the effects of the Mt. Elbert Pumped-Storage Powerplant on the ecology of Twin Lakes. Twin Lakes are a pair of connected dimictic lakes, formed as the result of glacial action on alluvial deposits. This report presents a taxonomic species study of the common plankton collected since 1974 from Twin Lakes. A total of 11 zooplankters and 14 phytoplankters were identified from the limnetic zone of Twin Lakes and the associated Mt. Elbert Forebay. The four divisions of zooplankton included four species of Rotifera (rotifer), three species of Copepoda (copepod), three species of Cladocera (cladoceran), and one species of Mysidacea (opossum shrimp).

Lieberman, D.M.

1983-02-01

317

Monitoring of genotoxic exposure of humans by the sister chromatid exchange test. Methodology and confounding factors.  

PubMed

During the last decades several in vitro assays for measurement of genotoxic exposure have been developed. Exposure of humans to genotoxic products in their workplaces and the environment may be evaluated by means of the sister chromatid exchange test (SCE), which visualize exchange of DNA material between sister chromatids of a chromosome. This thesis deals with the development of SCE methodology and screening of confounding factors to make the method useful in population monitoring of genotoxic exposure of chemicals in vivo. Human lymphocytes are cultured under standardized conditions. The cells are prepared for chromosome analysis by means of new-developed apparatuses treating 12 samples simultaneously. By this method the preparation is speeded up and breathing of glacial acetic acid is minimized. Slides are prepared and stained. The staining procedure includes irradiation of the slides with long wave UV light. The light source has been optimized with regard to simplicity and spectral distribution to fit the absorption spectrum of the dye bisbenzimid. The irradiation time and dose to produce distinct harlequin stained chromosomes has been found. Population screening demands analysis in microscope of a great number of chromosomes. The working time at microscope is long and improvement of ergonomics and automation to speed up the procedure was obtained by development of a special microscope which projects the picture of SCEs at table level. The scanning table was motorized. These changes gave excellent ergonomic proporties as fixed positions of the eyes and hands were avoided. The system is fast and flexible and may semiautomatically produce karyotypes. By pointing out SCEs the system automatically registers SCE number, cell coordinates, mitosis quality and perform statistics. The statistical model which best describe the distributions of SCE data has been analysed. This was a negative binomial distribution, which is close to the Poisson distribution. The transformation y = (S).5 + (S + 1).5 follows a normal distribution. Variances of the transformation of the sum of SCEs in 30 cells within subjects and between subjects have been calculated, and on that basis the demands to sample size have been calculated. To avoid to make false statements about a connection between an exposure and SCE a detailed knowledge of confounding factors is essential. Of endogenous factors gender, age, race, and heredity have been considered. Of these gender and age contribute to the variation in SCE. Very high SCE level has been found in healthy members of a family and such cases have to be excluded from exposure studies.(ABSTRACT TRUNCATED AT 400 WORDS) PMID:2188801

Wulf, H C

1990-04-01

318

A Novel, Homozygous c.1502T>G (p.Val501Gly) Mutation in the Thyroid peroxidase Gene in Malaysian Sisters with Congenital Hypothyroidism and Multinodular Goiter  

PubMed Central

Congenital hypothyroidism (CH) with multinodular goiter (MNG) is uncommonly seen in children. However, CH associated with goiter is often caused by defective Thyroid peroxidase (TPO) gene. In this study, we screened for mutation(s) in the TPO gene in two siblings with CH and MNG and their healthy family members. The two sisters, born to consanguineous parents, were diagnosed with CH during infancy and received treatment since then. They developed MNG during childhood despite adequate L-thyroxine replacement and negative thyroid antibody screening. PCR-amplification of all exons using flanking primers followed by DNA sequencing revealed that the two sisters were homozygous for a novel c.1502T>G mutation. The mutation is predicted to substitute valine for glycine at a highly conserved amino acid residue 501 (p.Val501Gly). Other healthy family members were either heterozygotes or mutation-free. The mutation was not detected in 50 healthy unrelated individuals. In silico analyses using PolyPhen-2 and SIFT predicted that the p.Val501Gly mutation is functionally “damaging.” Tertiary modeling showed structural alterations in the active site of the mutant TPO. In conclusion, a novel mutation, p.Val501Gly, in the TPO gene was detected expanding the mutation spectrum of TPO associated with CH and MNG.

Lee, Ching Chin; Harun, Fatimah; Jalaludin, Muhammad Yazid; Heh, Choon Han; Othman, Rozana; Mat Junit, Sarni

2013-01-01

319

Replication-Dependent Sister Chromatid Recombination in Rad1 Mutants of Saccharomyces Cerevisiae  

PubMed Central

Homolog recombination and unequal sister chromatid recombination were monitored in rad1-1/rad1-1 diploid yeast cells deficient for excision repair, and in control cells, RAD1/rad1-1, after exposure to UV irradiation. In a rad1-1/rad1-1 diploid, UV irradiation stimulated much more sister chromatid recombination relative to homolog recombination when cells were irradiated in the G(1) or the G(2) phases of the cell cycle than was observed in RAD1/rad1-1 cells. Since sister chromatids are not present during G(1), this result suggested that unexcised lesions can stimulate sister chromatid recombination events during or subsequent to DNA replication. The results of mating rescue experiments suggest that unexcised UV dimers do not stimulate sister chromatid recombination during the G(2) phase, but only when they are present during DNA replication. We propose that there are two types of sister chromatid recombination in yeast. In the first type, unexcised UV dimers and other bulky lesions induce sister chromatid recombination during DNA replication as a mechanism to bypass lesions obstructing the passage of DNA polymerase, and this type is analogous to the type of sister chromatid exchange commonly observed cytologically in mammalian cells. In the second type, strand scissions created by X-irradiation or the excision of damaged bases create recombinogenic sites that result in sister chromatid recombination directly in G(2). Further support for the existence of two types of sister chromatid recombination is the fact that events induced in rad1-1/rad1-1 were due almost entirely to gene conversion, whereas those in RAD1/rad1-1 cells were due to a mixture of gene conversion and reciprocal recombination.

Kadyk, L. C.; Hartwell, L. H.

1993-01-01

320

Initial Fetal Cardiovascular Profile Score Predicts Recipient Twin Outcome in Twin-Twin Transfusion Syndrome  

PubMed Central

Objective To assess the relationship between cardiomyopathy and recipient twin (RT) outcome in twin-twin transfusion syndrome (TTTS). Methods Fetal echocardiography and outcomes data in 62 consecutive pregnancies with TTTS was reviewed. The primary outcome was neonatal RT survival. Severity of RT cardiomyopathy at presentation was assessed by the Cardiovascular Profile Score (CVPS). RT outcome and odds of survival were compared between groups, stratified by CVPS. Results Overall neonatal survival for all fetuses was 61% (76/124). RT survival was 58% (36/62). Grouped by CVPS, RT survival was greater (50%) for those with a CVPS ? 9 and even higher (74%) for a CVPS =10. Amongst components of the CVPS, atrioventricular valve regurgitation (AVVR) was associated with negative RT outcome. Other factors at presentation were not predictive of RT outcome. Conclusions Normal CVPS in the RT in TTTS is predictive of improved survival compared to RT with abnormal CVPS, even RT with minor deductions. Standard clinical staging did not predict outcome. Cardiac assessment by CVPS may improve clinical decision making and timing of fetal interventions.

Shah, Amy D.; Border, William L.; Crombleholme, Timothy M.; Michelfelder, Erik C.

2008-01-01

321

NOTE: Trends of discordant fetal growth in monochorionic twin pregnancies  

Microsoft Academic Search

We derived simple analytical relations representing trends of discordant fetal growth in monochorionic twins developing the twin-twin transfusion syndrome from an approximation of previously developed model equations. In severe twin-twin transfusion syndrome cases, the difference between the estimated fetal weights of both twins increases proportional to (t-5)5 (t denotes gestational age in weeks) and the sum of both weights increases

Martin J. C. van Gemert; Asli Umur

2000-01-01

322

Characteristics of women lost to follow-up in cardiovascular community health interventions: findings from the Sister to Sister campaign.  

PubMed

Community-based interventions (CBI) have been targeted as a potential means of tackling cardiovascular disease in women. However, there have been mixed results in terms of their impact on health, with at least some of this being attributed to high attrition rates. This study explores factors that may be contributing to the low retention of women in cardiovascular CBIs. In 2009, Sister to Sister, a national organization that sponsors community health fairs, provided free cardiovascular health screenings for a total of 9,443 women nationwide. All participants were invited to enroll in a 1 year, survey-based observational study to assess the effectiveness of these community health screenings. Of these 9,443 women, 5.9 % actively participated in the follow-up study. Participants were more likely to have health insurance (75.5 vs. 65.3 %, p < 0.001), have an annual income above 75,000 dollars (26.7 vs. 19.7 %, p < 0.001), and identify themselves as white (50.0 vs. 31.5 %, p < 0.001). They were also more likely to have hypertension (32.1 vs. 27.4 %, p = 0.018) and metabolic syndrome (35.7 vs. 20.4 %, p < 0.001). Our results suggest that white, affluent women with health insurance and cardiovascular risk factors are more likely to engage in CBIs that require longitudinal assessment. This study gives insight into the demographics, socioeconomic status, and cardiovascular comorbidities of women who participate in cardiovascular CBIs. The results may prove to be useful in understanding the biopsychosocial barriers to participation in CBIs in order to develop more effective interventions in the future. PMID:23314921

Naderi, Sahar; Johnson, Caitlin E; Rodriguez, Fátima; Wang, Yun; Pollin, Irene; Foody, JoAnne M

2013-06-01

323

Transitory Increase in Middle Cerebral Artery Peak Systolic Velocity of Recipient Twins after Fetoscopic Laser Photocoagulation for Twin-Twin Transfusion Syndrome  

Microsoft Academic Search

Objective: It was the aim of this study to elucidate the clinical features of recipient twins with increased middle cerebral artery peak systolic velocity (MCA-PSV) after fetoscopic laser photocoagulation (FLP) for twin-twin transfusion syndrome. Methods: Serial Doppler velocimetry of the MCA was performed in 30 recipient twins before and after FLP. Clinical data and perinatal outcome were compared between cases

Keisuke Ishii; Takeshi Murakoshi; Mitsuru Matsushita; Takashi Sinno; Hiroo Naruse; Yuichi Torii

2008-01-01

324

[Social development of twins: the need for intervention to avoid adverse effects of twin language].  

PubMed

Social competence is one of the most important accomplishments of human development, and this skill in human relationships is learned through communication. Therefore, it is considered that delays in language development could be a barrier to building human relationships and social competence. Although it is well known that there are delays in language development in twins compared with that of singletons, little is known about how these linguistic delays affect the development of social competence. Because twin language is a language that is unique to each pair of twins and cannot be understood by either their mother or others, it may be assumed that the social competence of twins who have a twin language is less than that of twins who don't have a twin language. Therefore, in this prospective longitudinal study we also investigated the relationship between twin language and social competence. A mailed questionnaire survey was conducted in 958 mothers as a follow-up of a study conducted in 2004. As a result, 522 respondents returned the questionnaire (53.9%). In this study, we used only 256 twins aged 6- 12-years-old (school-age children) for analysis, excluding those with missing values. Multiple logistic regression analysis was employed. In the second child of twins, a low birth weight, the appearance of twin language and gestosis of the mother were positively related with social unbalance (OR = 1.846, 2.022 and 1.903). On the other hand, with the first child, however, there was no such link. The present results indicate that twin language might influence social competence in school-age children. It has been believed that linguistic intervention is unnecessary, because most twin language disappears spontaneously. However, early intervention, for example linguistic assistance by public health nurses or psychologists and early enrollment in a preschool may be necessary for twins with a twin language, to avoid adverse consequences in social competence at school-age. PMID:19068753

Hayashi, Chisato; Hayakawa, Kazuo; Maeda, Chiho; Nishihara, Reiko; Onoi, Miyuki

2008-10-01

325

Healthy Eating  

NSDL National Science Digital Library

It's important to eat the right things to keep our bodies happy and healthy. As you explore these sites, look for ways you can better give your body what it needs. There's still an hour until lunch, and you're hungry. You do have a candy bar that you got for your birthday. It looks really tasty, but is that really what your body needs. Your mom always says they're bad for you, and they'll make you sick. Is that ...

Thorpe, Mr.

2012-04-30

326

Discordant placental echogenicity: a novel sign of impaired placental perfusion in Twin-Twin transfusion syndrome?  

PubMed Central

Twin-Twin transfusion syndrome (TTTS) is present in approximately 5 to 15% of monochorionic-diamniotic twin pregnancies. A chronic blood flow imbalance through placental vascular anastomoses from the donor to the recipient twin is considered the pathophysiologic mechanism responsible for the development of TTTS. Discordant echogenicity between the donor and recipient placenta has been proposed in a previous case report as an additional sonographic sign of TTTS. Here, we present a case of TTTS with discordant placental echogenicity characterized by a hyperechoic and thicker placental side in the donor twin associated with reduced vascular Doppler signals, histologic lesions suggestive of ischemic changes, and overexpression of anti-angiogenic factors.

Kusanovic, Juan Pedro; Romero, Roberto; Gotsch, Francesca; Mittal, Pooja; Erez, Offer; Kim, Chong Jai; Hassan, Sonia S.; Espinoza, Jimmy; Yeo, Lami

2012-01-01

327

Growth of deformation twins in tantalum via coherent twin boundary migration  

NASA Astrophysics Data System (ADS)

In order to investigate the process of twinning growth, the nucleation of twinning dislocation loops on the coherent boundary of a Tantalum twin superlattice is studied via a molecular dynamics approach. We get homogeneous nucleation rates by means of a stationarity test and the mean first-passage method. We study their dependence on driving force and temperature in a framework given by the Kolgomorov-Johnson-Mehl-Avrami theory. Correspondingly, the contribution to the twinning growth dictated by this nucleation mechanism, as compared to the pole mechanism, is discussed. The homogeneous loop nucleation and growth mechanism can be relevant to twinning in high strain-rate experiments as in shock waves.

Sandoval, Luis A.; Surh, Michael P.; Chernov, Alexander A.; Richards, David F.

2013-09-01

328

The evolution of the leadership of religious sisters in Catholic elementary schools in the Archdiocese of Denver (1940--2001)  

Microsoft Academic Search

The purpose of this study was to see how 3 communities, the Sisters of Loretto, the Sisters of St. Joseph of Carondolet, Missouri, and the Sisters of Charity of Leavenworth, Kansas, chose leadership for their schools. These 3 communities have ministered in the Archdiocese of Denver from almost the beginning of their school system (1861). ^ The history of the

Virginia Chiambalero

2003-01-01

329

Attractiveness Differences Between Twins Predicts Evaluations of Self and Co-Twin  

PubMed Central

One of the most consistent findings in psychology shows that people prefer and make positive attributions about attractive compared with unattractive people. The goal of the current study was to determine the power of attractiveness effects by testing whether these social judgments are made where attractiveness differences are smallest: between twins. Differences in facial attractiveness predicted twins’ evaluations of self and their co-twin (n = 158; 54 male). In twin pairs, the more attractive twin judged their less attractive sibling as less physically attractive, athletic, socially competent, and emotionally stable. The less attractive twin did the reverse. Given that even negligible differences in facial attractiveness predicted self and co-twin attitudes, these results provide the strongest test yet of appearance-based stereotypes.

Principe, Connor P.; Rosen, Lisa H.; Taylor-Partridge, Teresa; Langlois, Judith H.

2012-01-01

330

Attractiveness Differences Between Twins Predicts Evaluations of Self and Co-Twin.  

PubMed

One of the most consistent findings in psychology shows that people prefer and make positive attributions about attractive compared with unattractive people. The goal of the current study was to determine the power of attractiveness effects by testing whether these social judgments are made where attractiveness differences are smallest: between twins. Differences in facial attractiveness predicted twins' evaluations of self and their co-twin (n = 158; 54 male). In twin pairs, the more attractive twin judged their less attractive sibling as less physically attractive, athletic, socially competent, and emotionally stable. The less attractive twin did the reverse. Given that even negligible differences in facial attractiveness predicted self and co-twin attitudes, these results provide the strongest test yet of appearance-based stereotypes. PMID:23467329

Principe, Connor P; Rosen, Lisa H; Taylor-Partridge, Teresa; Langlois, Judith H

2012-04-10

331

Placental markers of twin-to-twin transfusion syndrome in diamniotic–monochorionic twins: A morphometric analysis of deep artery-to-vein anastomoses  

Microsoft Academic Search

Twin-to-twin transfusion syndrome (TTTS) is a multifactorial disorder that develops in 9–15% of diamniotic–monochorionic twin gestations. While the pathogenesis of TTTS remains poorly understood, unbalanced deep artery-to-vein (AV) anastomoses have traditionally been implicated in the gradual shift of blood from donor to recipient. The aim of this study was to define the placental markers of twin-to-twin transfusion syndrome, with special

M. E. De Paepe; S. Shapiro; D. Greco; V. L. Luks; R. G. Abellar; C. H. Luks; F. I. Luks

2010-01-01

332

Chromosome-specific nonrandom sister chromatid segregation during stem-cell division.  

PubMed

Adult stem cells undergo asymmetric cell division to self-renew and give rise to differentiated cells that comprise mature tissue. Sister chromatids may be distinguished and segregated nonrandomly in asymmetrically dividing stem cells, although the underlying mechanism and the purpose it may serve remain elusive. Here we develop the CO-FISH (chromosome orientation fluorescence in situ hybridization) technique with single-chromosome resolution and show that sister chromatids of X and Y chromosomes, but not autosomes, are segregated nonrandomly during asymmetric divisions of Drosophila male germline stem cells. This provides the first direct evidence, to our knowledge, that two sister chromatids containing identical genetic information can be distinguished and segregated nonrandomly during asymmetric stem-cell divisions. We further show that the centrosome, SUN-KASH nuclear envelope proteins and Dnmt2 (also known as Mt2) are required for nonrandom sister chromatid segregation. Our data indicate that the information on X and Y chromosomes that enables nonrandom segregation is primed during gametogenesis in the parents. Moreover, we show that sister chromatid segregation is randomized in germline stem cell overproliferation and dedifferentiated germline stem cells. We propose that nonrandom sister chromatid segregation may serve to transmit distinct information carried on two sister chromatids to the daughters of asymmetrically dividing stem cells. PMID:23644460

Yadlapalli, Swathi; Yamashita, Yukiko M

2013-05-05

333

Chromosome orientation fluorescence in situ hybridization (CO-FISH) to study sister chromatid segregation in vivo  

PubMed Central

Previously, assays for sister chromatid segregation patterns relied on incorporation of BrdU and indirect methods to infer segregation patterns after two cell divisions. Here we describe a method to differentially label sister chromatids of murine cells and directly assay sister chromatid segregation patterns following one cell division in vitro and in vivo by adaptation of the well-established CO-FISH (chromosome orientation fluorescent in situ hybridization) technique. 5-bromo-2?-deoxyuridine (BrdU) is incorporated into newly-formed DNA strands, followed by photolysis and exonuclease digestion to create single-stranded sister chromatids containing parental template DNA only. Such single-stranded sister chromatids are differentially labeled using unidirectional probes to major satellite sequences coupled to fluorescent markers. Differentially-labeled sister chromatids in post-mitotic cells are visualized using fluorescence microscopy and sister chromatid segregation patterns can be directly assayed after one cell division. This procedure requires four days for in vivo mouse tissues, and two days for in vitro cultured cells.

Falconer, Ester; Chavez, Elizabeth; Henderson, Alexander; Lansdorp, Peter M.

2013-01-01

334

Links Between Sisters' Sexual and Dating Victimization: The Roles of Neighborhood Crime and Parental Controls  

PubMed Central

This study examined the extent to which a sister’s prior sexual and dating victimization is a risk factor for young women being similarly victimized and the possible factors underlying a co-occurrence. The sample involved 122 young adult Latina or African American sister pairs (244 women; ages 16–25) who resided in low-income, urban neighborhoods. Results indicated that women whose sisters had been victimized had increased risk of victimization even after controlling for neighborhood crime, parental controls, age and race–ethnicity (odds ratios were 4.0 for unwanted touching, 6.2 for a forced sex act, and 16.7 for dating violence). In high-crime neighborhoods, the presence of two adult parent figures in the home was associated with women’s reduced likelihood of unwanted touching, and mothers’ high monitoring during adolescence was associated with women’s lower risk of dating aggression. Survival analysis results showed that the risk period of a second sister being victimized lasts between 7 and 10 years after a first sister’s victimization. The prevention implications of study findings are discussed.

East, Patricia L.; Chien, Nina C.; Adams, Joyce A.; Hokoda, Audrey; Maier, Ashley

2013-01-01

335

Women in-between' (Strathern, 1995): the ambiguous position of the sister tutor, 1918-1960.  

PubMed

The purpose of this article is to explore the ambiguous position of sister tutors, within the nursing and hospital hierarchy between 1918 and 1960. The function of the sister tutor was to train the probationers (student nurses). However, I will argue that the students' education was to come second to the service needs of the hospital, the authority of the matron and desire of the medical profession to maintain control over the nursing curriculum and nursing practice. Therefore sister tutors were caught 'in-between' several opposing forces which together militated against the individual sister tutor's work and the ability of the nursing profession to recruit adequate numbers of senior nurses into the classroom. The recruitment issue was further hampered by the widespread knowledge that much of the sister tutor's work was not student education at all, but organising lectures by medical staff and marking students' notes. In order to gauge the 'official' attitudes to the sister tutors and also the experiences of those who either worked as sister tutors or were taught by them, I used both archival and oral evidence in the research for this article. Pseudonyms have been used throughout for the oral history respondents. PMID:16766093

Brooks, Jane

2007-02-01

336

Reversed lateral dominance in identical twins  

Microsoft Academic Search

The evidence from this study of 17 pairs of identical twins reveals that one twin is right dominant and the other left dominant in practically every case of the phi-test (a test based on the laterality of apparent movement in binocular perception). Such reversal on other tests of lateral dominance occurs but seldom, although an indication of reversal on both

E. T. Raney

1938-01-01

337

First trimester diagnosis of dicephalus conjoined twins  

Microsoft Academic Search

Dicephalus twinning is an extremely rare type of conjoined twins. Early prenatal diagnosis of this condition is important to provide an opportunity for pregnancy termination. We present such a case, which was diagnosed by ultrasound examination at 12 weeks of gestation. The ultrasonographic criteria are discussed together with implications for management.

George Daskalakis; Athanasios Pilalis; Ioannis Tourikis; George Moulopoulos; Ioannis Karamoutzos; Aris Antsaklis

2004-01-01

338

Twin, association and current "omics" studies.  

PubMed

Abstract This paper describes the estimation of heritability, the genetic analysis of comorbid traits based on twin designs and on indices based on measured genetic relatedness. Next, approaches to identify genes and to examine the modification of heritability are described. The paper concludes with a discussion on the continued value of twin studies. PMID:24059544

Boomsma, Dorret I

2013-10-01

339

Hypertensive disorders in twin versus singleton gestations  

Microsoft Academic Search

Objective: This study was undertaken to compare rates and severity of gestational hypertension and preeclampsia, as well as perinatal outcomes when these complications develop, between women with twin gestations and those with singleton gestations. Study Design: This was a secondary analysis of prospective data from women with twin (n = 684) and singleton (n = 2946) gestations enrolled in two

Baha M. Sibai; John Hauth; Steve Caritis; Marshall D. Lindheimer; Cora MacPherson; Mark Klebanoff; J. Peter VanDorsten; Mark Landon; Menachem Miodovnik; Richard Paul; Paul Meis; Gary Thurnau; Mitchell Dombrowski; James Roberts; Donald McNellis

2000-01-01

340

[Hungarian twin studies: results of four decades].  

PubMed

Twin studies play a role in examining the contribution of genetic variations and environmental factors responsible for the determination of phenotypic variables and of genetic linkage between genotypes. Hungarian twin studies, supported by three twin registries (among them two twin-database), date back to 1970s. Studies mainly focused on various congenital abnormalities, the effect of contraceptive pills and folic acid on the frequency of twin pregnancies, as well as psychosexual and alcohol consumptional behaviors. Monogenic Mendelian inheritance of lactose (mal)absorption was demonstrated for the first time. Hungarian Twin Registry was founded in 2007, which contributed to the current understanding on the background of several disorders, e.g. metabolic syndrome and atherosclerosis. As part of an international twin study, among others, arterial stiffness, central blood pressure, carotid intima/media thickness, venous biomechanics, body composition, lung function and smoking characteristics were also assessed. Absence of genetic background in non-alcoholic fatty liver disease and high inheritance of carotid plaque characteristics were demonstrated for the first time. The review also aims to summarize future plans of the Hungarian Twin Registry. Orv. Hetil., 2013, 154, 1579-1586. PMID:24077161

Tárnoki, Adám Domonkos; Tárnoki, Dávid László; Horváth, Tamás; Métneki, Júlia; Littvay, Levente

2013-10-01

341

TWINS Observations of Oxygen ENA Flux  

Microsoft Academic Search

As part of the science objectives of the TWINS (Two Wide-angle Imaging Neutral-atom Spectrometers) mission, we aim to enhance the knowledge of the workings of our magnetosphere by contributing compositional information of the observed energetic neutral atom (ENA) flux from the two TWINS instruments. We will present images of oxygen (O) ENA flux varying over time and space. Results from

J. C. Alquiza; J. Goldstein; M. Gruntman; D. J. McComas; J. Redfern; P. W. Valek

2009-01-01

342

Ectodermal dysplasia in identical twins.  

PubMed

Hereditary hypohidrotic ectodermal dysplasia (HED) is typically inherited as an X-linked recessive trait, characterized by deformity of at least two or more of the ectodermal structures - hair, teeth, nails and sweat glands. Two cases of hereditary HED involving identical male twins, is being documented for the rarity of its occurrence with special attention given to genetics, pathophysiology, clinical, intraoral manifestations and to the methods to improve the masticatory function, the facial esthetics and psychology of patients affected by this disease. PMID:23956595

Puttaraju, Gurkar Haraswarupa; Visveswariah, Paranjyothi Magadi

2013-07-01

343

Prediction of steady-state plasma levels of nortriptyline from single oral dose kinetics: A study in twins  

Microsoft Academic Search

Five identical (monozygotic) and 6 fraternal (dizygotic) sets of healthy twins between 47 and 53 years of age were given a single oral dose of nortriptyline (NT) hydrochloride 1 mg\\/kg. The plasma half-life, the apparent volume of distribution, and the plasma clearance of NT were estimated for each subject as well as the urinary excretion rate of conjugated and unconjugated

B. Alexanderson

1973-01-01

344

Use of twins to study environmental effects.  

PubMed Central

Extrapolation from pharmacogenetic studies would indicate that there is a great deal of genetic variability in the response of humans to noxious environmental agents. Co-twins provide the most closely matched genetic controls possible and, in addition, are matched perfectly for age and often have shared very similar environments since before birth. The efficiency of co-twin control studies can be further increased by the use of sequential analysis, so that for the studies of the effects of environmental agents on human populations, twins would give answers that would require many more unrelated subjects. Use of twins in epidemiology studies is now in its infancy, but investigators should carefully consider the use of this powerful experimental tool and begin to identify twins in population surveys.

Christian, J C

1981-01-01

345

Establishment and maintenance of sister chromatid cohesion in fission yeast by a unique mechanism  

PubMed Central

During S phase, chromatid cohesion is established only between nascent sisters and with faithful pairing along their entire region, but how this is ensured is unknown. Here we report that sister chromatid cohesion is formed and maintained by a unique mechanism. In fission yeast, Eso1p, functioning in close coupling to DNA replication, establishes sister chromatid cohesion whereas the newly identified Cohesin-associated protein Pds5p hinders the establishment of cohesion until counteracted by Eso1p, yet stabilizes cohesion once it is established. Eso1p interacts physically with Pds5p via its Ctf7p/Eco1p-homologous domain.

Tanaka, Koichi; Hao, Zhonglin; Kai, Mihoko; Okayama, Hiroto

2001-01-01

346

Healthy Air at Work  

MedlinePLUS

... Home > Healthy Air > At Work Healthy Air at Work Employees should be safe while on the job; ... the workplace threatens workers' lives. Healthy Air at Work Healthy air quality is an important element of ...

347

Ecologically distinct dinosaurian sister group shows early diversification of Ornithodira.  

PubMed

The early evolutionary history of Ornithodira (avian-line archosaurs) has hitherto been documented by incomplete (Lagerpeton) or unusually specialized forms (pterosaurs and Silesaurus). Recently, a variety of Silesaurus-like taxa have been reported from the Triassic period of both Gondwana and Laurasia, but their relationships to each other and to dinosaurs remain a subject of debate. Here we report on a new avian-line archosaur from the early Middle Triassic (Anisian) of Tanzania. Phylogenetic analysis places Asilisaurus kongwe gen. et sp. nov. as an avian-line archosaur and a member of the Silesauridae, which is here considered the sister taxon to Dinosauria. Silesaurids were diverse and had a wide distribution by the Late Triassic, with a novel ornithodiran bauplan including leaf-shaped teeth, a beak-like lower jaw, long, gracile limbs, and a quadrupedal stance. Our analysis suggests that the dentition and diet of silesaurids, ornithischians and sauropodomorphs evolved independently from a plesiomorphic carnivorous form. As the oldest avian-line archosaur, Asilisaurus demonstrates the antiquity of both Ornithodira and the dinosaurian lineage. The initial diversification of Archosauria, previously documented by crocodilian-line archosaurs in the Anisian, can now be shown to include a contemporaneous avian-line radiation. The unparalleled taxonomic diversity of the Manda archosaur assemblage indicates that archosaur diversification was well underway by the Middle Triassic or earlier. PMID:20203608

Nesbitt, Sterling J; Sidor, Christian A; Irmis, Randall B; Angielczyk, Kenneth D; Smith, Roger M H; Tsuji, Linda A

2010-03-01

348

Healthy Water Healthy People Field Monitoring Guide  

ERIC Educational Resources Information Center

|This 100-page manual serves as a technical reference for the "Healthy Water, Healthy People Water Quality Educators Guide" and the "Healthy Water Healthy People Testing Kits". Yielding in-depth information about ten water quality parameters, it answers questions about water quality testing using technical overviews, data interpretation…

Project WET Foundation, 2003

2003-01-01

349

NOTE: Modelling the influence of amnionicity on the severity of twin twin transfusion syndrome in monochorionic twin pregnancies  

NASA Astrophysics Data System (ADS)

Clinical treatment for diamniotic monochorionic twin twin transfusion syndrome (TTTS) may include conversion of diamniotic pregnancies to a monoamniotic monochorionic state by disrupting the amnion septum. We sought to test the underlying hypothesis, i.e. that a monoamniotic state reduces the severity of TTTS. With use of our previously developed mathematical model of two equal fetoplacental circulatory units connected by various sizes and types of placental anastomoses, we compared the haemodynamic and amniotic fluid dynamics of monoamniotic and diamniotic twins that develop TTTS. We used three anastomotic patterns that produce severe, moderate or mild forms of TTTS, respectively, in our diamniotic monochorionic twin model. Monoamnionicity was modelled by adding the two amniotic fluid volumes and using the volume-averaged amniotic fluid osmolality. The results were as follows: for severe TTTS, small differences develop between diamniotic and monoamniotic donor twins in fetal urine production, swallowed volume, blood volume, blood pressures, net fetofetal transfusion, and blood and amniotic fluid osmolality. However, the circulatory imbalance between the monoamniotic twins deteriorates similar to that of diamniotic twins. The pathophysiological differences tend to disappear for milder TTTS. In conclusion, our model suggests that the uncommon finding of TTTS in monoamniotic twins is not due to the presence of a single amniotic sac. Rather, clinically significant differences in anastomotic patterns and the delayed or lack of identification of manifestations in monoamniotic twins account for the reduced rate of TTTS diagnosis. Based on these results we expect the clinical disruption of the amnion septum in diamniotic monochorionic TTTS pregnancies to have only minimal benefits.

van den Wijngaard, Jeroen P. H. M.; Umur, Asli; Ross, Michael G.; van Gemert, Martin J. C.

2004-03-01

350

Corpus Callosum Diffusion Anisotropy Correlates with Neuropsychological Outcomes in Twins Disconcordant for Traumatic Brain Injury  

PubMed Central

SUMMARY Conventional and diffusion tensor MR imaging studies in twins sustaining severe pediatric traumatic brain injury identified reduction in fractional anisotropy (FA) in all regions of the corpus callosum, particularly the posterior body, rostral body, and genu, relative to healthy cotwins. FA from the rostrum, genu, anterior body, posterior body, and isthmus were correlated with measures of reading speed and comprehension; verbal working memory and math fact retrieval scores were correlated only with the rostral body FA.

Ewing-Cobbs, L.; Hasan, K.M.; Prasad, M.R.; Kramer, L.; Bachevalier, J.

2007-01-01

351

Macromolecular crystal twinning, lattice disorders and multiple crystals  

Microsoft Academic Search

Macromolecule crystal structure analyses can be severely hampered by cases of twinning or of lattice disorders or of multiple crystals. However, it is increasingly the case that twinning can readily be recognized and accounted for, or remediations found. A review of this topic is given, covering both the less-than-perfect and perfect twinning situations. Remediation of twinning cases is possible via

J. R. Helliwell

2008-01-01

352

A TWIN RESEARCH PERSPECTIVE ON READING AND SPELLING DISABILITIES  

Microsoft Academic Search

A review of twin research on reading and spelling disabilities fulfills two key functions: First, the special educational and developmental concerns of twins are highlighted. Second, the value of twin studies for investigating genetic and environmental factors underlying learning disabilities in a variety of cognitive domains is demonstrated. The discussion is introduced by a review of biological aspects of twinning

Nancy L. Segal; Tari D. Topoloski

1995-01-01

353

An unusual case of monozygotic epigastric heteropagus twinning  

Microsoft Academic Search

Epigastric heteropagus refers to unequal and asymmetric conjoined twins in which the dependent component (parasite) is smaller and usually attached to the epigastrium of the dominant component (autosite). Epigastric heteropagus is a very rare type of conjoined twins. It is generally assumed that conjoined twins represent a form of monozygotic twinning, but there has been no confirmation of this monozygotic

Eui Ho Hwang; Seok Joo Han; Jin-Sung Lee; Myo Kyung Lee

1996-01-01

354

Influences on achieving motor milestones: A twin-singleton study  

Microsoft Academic Search

n order to determine if twinning impacted achieve- ment of motor milestones the attainment of early motor milestones in twins was examined and com- pared to published data from singletons of the same age from the same culture and birth years. We examined the influence of twinning, sex, zygosity and birth cohort (1987-2001) on the motor develop- ment of twins

Silvia I. Brouwer; Beijsterveldt van C. E. M; Meike Bartels; James J. Hudziak; Dorret I. Boomsma

2006-01-01

355

Observed frequency of monozygotic twinning in Holstein dairy cattle  

Microsoft Academic Search

Bonnier's equation is used to mathematically estimate the frequency of monozygotic (MZ) twinning in epidemiologic studies of twinning in dairy cattle; however, no empirical determination of MZ twinning has been reported in the literature. Our objectives were to empirically determine the frequency of MZ twinning in lactating Holstein cows and to compare this result with published estimates predicted using Bonnier's

N. Silva del Río; B. W. Kirkpatrick; P. M. Fricke

2006-01-01

356

197. Photocopy of drawing, Twin Falls, Canal Company, date unknown. ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

197. Photocopy of drawing, Twin Falls, Canal Company, date unknown. GATE STEMS AND LIFTING DEVICES, NO COUNTY; BLUEPRINT SKETCHES. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

357

Heredity-Environment Interaction in the Development of Twins  

Microsoft Academic Search

As an alternative to the commonly used additive model for interpreting twin data, interactional aspects on a longitudinal twin study are presented.While experiencing the same environment MZ twins will tend to react to it similarly, while DZ twins will react differently. Interaction between genetic and environmental factors will therefore increase the difference among DZ, thus lowering the intra-class correlation with

Siv Fischbein

1978-01-01

358

Dislocation Mechanism of Twinning in Ni-Mn-Ga  

NASA Astrophysics Data System (ADS)

Tensile tests were performed in situ in a transmission electron microscope to investigate the twinning mechanism in non-modulated Ni-Mn-Ga martensite. The reorientation of the twin variants occurs via twinning dislocations. Their generation and movement were followed; the glide plane and Burgers vector were verified. Individual twinning dislocations were visualized.

Zárubová, N.; Ge, Y.; Gemperlová, J.; Gemperle, A.; Hannula, S.-P.

2012-03-01

359

Comparison of the US Air Force Fitness Test and Sister Services' Combat-Oriented Fitness Tests.  

National Technical Information Service (NTIS)

This research explores how the United States Air Force Physical Fitness Test (AFPFT) events compare to sister-services' physical fitness test events with respect to their predictability of combat capability. Multiple regression tools, non-parametric analy...

T. E. Worden

2009-01-01

360

20 CFR 725.224 - Determination of relationship; parent, brother, or sister.  

Code of Federal Regulations, 2010 CFR

...2009-04-01 false Determination of relationship; parent, brother, or sister...Duration of Entitlement: Miner's Dependents (augmented Benefits) § 725.224 Determination of relationship; parent, brother, or...

2009-04-01

361

20 CFR 725.224 - Determination of relationship; parent, brother, or sister.  

Code of Federal Regulations, 2013 CFR

...2013-04-01 false Determination of relationship; parent, brother, or sister...Duration of Entitlement: Miner's Dependents (augmented Benefits) § 725.224 Determination of relationship; parent, brother, or...

2013-04-01

362

Sister Circles as a Culturally Relevant Intervention for Anxious African American Women  

PubMed Central

Research on anxiety treatment with African American women reveals a need to develop interventions that address factors relevant to their lives. Such factors include feelings of isolation, multiple roles undertaken by Black women, and faith. A recurrent theme across treatment studies is the importance of having support from other Black women. Sister circles are support groups that build upon existing friendships, fictive kin networks, and the sense of community found among African Americans females. Sister circles appear to offer many of the components Black women desire in an anxiety intervention. In this article, we explore sister circles as an intervention for anxious African American women. Culturally-infused aspects from our sister circle work with middle-class African American women are presented. Further research is needed.

Neal-Barnett, Angela; Stadulis, Robert; Murray, Marsheena; Payne, Margaret Ralston; Thomas, Anisha; Salley, Bernadette B.

2011-01-01

363

Catholic Nursing Sisters and Brothers and Racial Justice in Mid-20th-Century America  

PubMed Central

This historical article considers nursing’s work for social justice in the 1960s civil rights movement through the lens of religious sisters and brothers who advocated for racial equality. The article examines Catholic nurses’ work with African Americans in the mid-20th century that took place amid the prevailing social conditions of poverty and racial disempowerment, conditions that were linked to serious health consequences. Historical methodology is used within the framework of “bearing witness,” a term often used in relation to the civil rights movement and one the sisters themselves employed. Two situations involving nurses in the mid-20th century are examined: the civil rights movement in Selma, Alabama, and the actions for racial justice in Chicago, Illinois. The thoughts and actions of Catholic sister and brother nurses in the mid-20th century are chronicled, including those few sister nurses who stepped outside their ordinary roles in an attempt to change an unjust system entirely.

Wall, Barbra Mann

2009-01-01

364

Hypothesis test for synchronization: Twin surrogates revisited  

NASA Astrophysics Data System (ADS)

The method of twin surrogates has been introduced to test for phase synchronization of complex systems in the case of passive experiments. In this paper we derive new analytical expressions for the number of twins depending on the size of the neighborhood, as well as on the length of the trajectory. This allows us to determine the optimal parameters for the generation of twin surrogates. Furthermore, we determine the quality of the twin surrogates with respect to several linear and nonlinear statistics depending on the parameters of the method. In the second part of the paper we perform a hypothesis test for phase synchronization in the case of experimental data from fixational eye movements. These miniature eye movements have been shown to play a central role in neural information processing underlying the perception of static visual scenes. The high number of data sets (21 subjects and 30 trials per person) allows us to compare the generated twin surrogates with the ``natural'' surrogates that correspond to the different trials. We show that the generated twin surrogates reproduce very well all linear and nonlinear characteristics of the underlying experimental system. The synchronization analysis of fixational eye movements by means of twin surrogates reveals that the synchronization between the left and right eye is significant, indicating that either the centers in the brain stem generating fixational eye movements are closely linked, or, alternatively that there is only one center controlling both eyes.

Romano, M. Carmen; Thiel, Marco; Kurths, Jürgen; Mergenthaler, Konstantin; Engbert, Ralf

2009-03-01

365

TWINS Observations of Oxygen ENA Flux  

NASA Astrophysics Data System (ADS)

As part of the science objectives of the TWINS (Two Wide-angle Imaging Neutral-atom Spectrometers) mission, we aim to enhance the knowledge of the workings of our magnetosphere by contributing compositional information of the observed energetic neutral atom (ENA) flux from the two TWINS instruments. We will present images of oxygen (O) ENA flux varying over time and space. Results from a few cases of TWINS flight data of geomagnetic significance will be presented with this analysis. One such example is a simultaneous and continuous observation of a minor geomagnetic storm (-60 nT) on 11 Oct 2008 as seen by both TWINS instruments. Initial TWINS images of this event show evidences of low-altitude emissions (LAEs) near the limb of the Earth and ring current signatures as well. Our compositional analysis is based on the secondary electron pulse height (PH) distributions measured by TWINS. Secondary electrons are generated as ENAs pass through an ultra-thin carbon foil in the TWINS instrument apertures. The secondary electron (PH) distribution varys as a function of the ENA’s energy and mass. The observed PH functions are then compared to the secondary electron PH distributions determined during instrument calibration. The flight data are simply treated as a linear combination of the two anticipated and most abundant species of magnetospheric ENAs, i.e., hydrogen (H) and oxygen (O).

Alquiza, J. C.; Goldstein, J.; Gruntman, M.; McComas, D. J.; Redfern, J.; Valek, P. W.

2009-12-01

366

The Sri Lankan Twin Registry: 2012 update.  

PubMed

The Sri Lankan Twin Registry (SLTR), established in 1997, is a unique resource for twin and genetic research in a low- and middle-income country (LMIC). It comprises of a volunteer cohort of 14,120 twins (7,060 pairs) and 119 sets of triplets, and a population-based cohort of 19,040 (9,520 pairs) twins and 89 sets of triplets. Several studies have been conducted using this registry, including the Colombo Twin and Singleton Study (CoTaSS 1; 4,387 twins, 2,311 singletons), which have explored the prevalence and heritability of a range of psychiatric disorders as well as gene-environmental interplay. Currently, a follow-up study (CoTaSS 2) of the same cohort is underway, looking at the prevalence and interrelationship of key cardiovascular and metabolic risk markers (e.g., metabolic syndrome). A significant feature of CoTaSS 2 is the establishment of a biobank. Current SLTR work is extending beyond mental health and the interface between mental and physical health to new horizons, extending collaborations with the wider global twin research community. Ethics and governance have been given special emphasis in the initiative. Capacity building and public engagement are two crucial components. Establishment of a state-of-the-art genetic laboratory was a major accomplishment. SLTR is a classic showcase of successful North-South partnership in building a progressive research infrastructure in a LMIC. PMID:23302519

Sumathipala, Athula; Siribaddana, Sisira; Hotopf, Mathew; McGuffin, Peter; Glozier, Nick; Ball, Harriet; Kovas, Yulia; Rijsdijk, Fruhling; Yatawara, Lalani; Pariante, Carmine; Zavos, Helena; Siriwardhana, Chesmal; Pannala, Gayani; Jayaweera, Kaushalya; Adikari, Anushka; Gunewardane, Dinesha

2013-01-10

367

Sister chromatid exchange data fit with a mixture of Poisson distributions  

Microsoft Academic Search

Bowman et al. [K.O. Bowman, Wesley Eddings, Marvin A. Kastenbaum, L.R. Shenton. Sister chromatid exchange data and Gram–Charlier series, Mutat. Res., 403 (1998) 159–169.] have shown that a Gram–Charlier modification of a negative binomial distribution gives a reasonable fit to counts of sister chromatid exchange (SCE) data originally presented by Bender et al. [M.A. Bender, R.J. Preston, R. C. Leonard,

R. H. Byers; L. R. Shenton

1999-01-01

368

Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I  

Microsoft Academic Search

Segregation of homologous maternal and paternal centromeres to opposite poles during meiosis I depends on post-replicative crossing over between homologous non-sister chromatids, which creates chiasmata and therefore bivalent chromosomes. Destruction of sister chromatid cohesion along chromosome arms due to proteolytic cleavage of cohesin's Rec8 subunit by separase resolves chiasmata and thereby triggers the first meiotic division. This produces univalent chromosomes,

Christian G. Riedel; Vittorio L. Katis; Yuki Katou; Saori Mori; Takehiko Itoh; Wolfgang Helmhart; Marta Gálová; Mark Petronczki; Juraj Gregan; Bulent Cetin; Ingrid Mudrak; Egon Ogris; Karl Mechtler; Laurence Pelletier; Frank Buchholz; Katsuhiko Shirahige; Kim Nasmyth

2006-01-01

369

Random homologous pairing and incomplete sister chromatid alignment are common in angiosperm interphase nuclei  

Microsoft Academic Search

The chromosome arrangement in interphase nuclei is of growing interest, e.g., the spatial vicinity of homologous sequences\\u000a is decisive for efficient repair of DNA damage by homologous recombination, and close alignment of sister chromatids is considered\\u000a as a prerequisite for their bipolar orientation and subsequent segregation during nuclear division. To study the degree of\\u000a homologous pairing and of sister chromatid

Veit Schubert; Young-Min Kim; Alexandre Berr; Jörg Fuchs; Armin Meister; Sylvia Marschner; Ingo Schubert

2007-01-01

370

LACK OF SPONTANEOUS SISTER CHROMATID EXCHANGES IN SOMATIC CELLS OF DROSOPHILA MELANOGASTER  

Microsoft Academic Search

Neural ganglia of wild type third-instar larvae of Drosophila melanogasier were incubated for 13 hours at various concentrations of BUdR (1, 3, 9, 27 pg\\/ml) . Metaphases were collected with colchicine, stained with Hoechst 33258, and scored under a fluorescence microscope. Metaphases in which the sister chromatids were clearly differentiated were scored for the presence of sister-chromatid exchanges (SCEs) .

M. GATTI; G. SANTINI; S. PIMPINELLI; G. OLIVIERI

371

Sisters in Science: Teachers’ reflective dialogue on confronting the gender gap  

Microsoft Academic Search

Sisters in Science, like many other programs aimed at fostering girls’ interest and achievement in science, is designed to\\u000a encourage more girls and woment to prepare for the careers in math, science, and technology that will dominate the 21st century. One of the foci of Sisters in Science was on the role of teachers as decisiomnakers in promoting science literacy

Penny L. Hammrich; Greer M. Richardson; Beverly Livingston

2000-01-01

372

The prosecution of Chinese organized crime groups: the Sister Ping case and its lessons  

Microsoft Academic Search

This article analyzes the investigation and prosecution of contemporary Chinese criminal organizations through the study of\\u000a one major human smuggling case: the trial of “Sister Ping.” Data were obtained from media reports, court documents, and from\\u000a interviews with parties familiar with the case. It is argued that modern human smuggling groups such as the one run by Sister\\u000a Ping are

Andrew J. Sein

2008-01-01

373

Linking Sister Chromatid Cohesion and Apoptosis: Role of Rad21  

PubMed Central

Rad21 is one of the major cohesin subunits that holds sister chromatids together until anaphase, when proteolytic cleavage by separase, a caspase-like enzyme, allows chromosomal separation. We show that cleavage of human Rad21 (hRad21) also occurs during apoptosis induced by diverse stimuli. Induction of apoptosis in multiple human cell lines results in the early (4 h after insult) generation of 64- and 60-kDa carboxy-terminal hRad21 cleavage products. We biochemically mapped an apoptotic cleavage site at residue Asp-279 (D279) of hRad21. This apoptotic cleavage site is distinct from previously described mitotic cleavage sites. hRad21 is a nuclear protein; however, the cleaved 64-kDa carboxy-terminal product is translocated to the cytoplasm early in apoptosis before chromatin condensation and nuclear fragmentation. Overexpression of the 64-kDa cleavage product results in apoptosis in Molt4, MCF-7, and 293T cells, as determined by TUNEL (terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick end labeling) and Annexin V staining, assaying of caspase-3 activity, and examination of nuclear morphology. Given the role of hRad21 in chromosome cohesion, the cleaved C-terminal product and its translocation to the cytoplasm may act as a nuclear signal for apoptosis. In summary, we show that cleavage of a cohesion protein and translocation of the C-terminal cleavage product to the cytoplasm are early events in the apoptotic pathway and cause amplification of the cell death signal in a positive-feedback manner.

Pati, Debananda; Zhang, Nenggang; Plon, Sharon E.

2002-01-01

374

Nanoscale growth twins in sputtered metal films  

SciTech Connect

We review recent studies on the mechanical properties of sputtered Cu and 330 stainless steel films with {l_brace}1 1 1{r_brace} nanoscale growth twins preferentially oriented perpendicular to growth direction. The mechanisms of formation of growth twins during sputtering and the deformation mechanisms that enable usually high strengths in nanotwinned structures are highlighted. Growth twins in sputtered films possess good thermal stability at elevated temperature, providing an approach to extend the application of high strength nanostructured metals to higher temperatures.

Misra, Amit [Los Alamos National Laboratory; Anderoglu, Osman [Los Alamos National Laboratory; Hoagland, Richard G [Los Alamos National Laboratory; Zhang, X [TEXAS A& M

2008-01-01

375

Dissimilar courses of twins with leukemia.  

PubMed

Twin girls, genetically identical, probably experienced different leukemogenic events and presented with acute lymphocytic leukemia 6 years apart. Their clinical presentations were similar, but they received significantly different therapy. The first twin died 34 months after diagnosis following multiple remissions and relapses, having received single-drug maintenance. The second twin remains free of apparent disease 60 months after diagnosis, following vincristine and prednisone induction, 6-mercaptopurine maintenance, methotrexate and prednisone reinforcement, and central nervous system treatment of occult disease. Their dissimilar clinical courses may have been due to different leukemogenic events and/or markedly different therapeutic programs. PMID:284166

Stewart, S J; Shepherd, D A; Steuber, C P; Starling, K A; Falletta, J M

1977-01-01

376

Pregnancy Induced Hypertension in Twin Pregnancy  

Microsoft Academic Search

Results: Pregnancy induced hypertension was found to at develop 18.36% in the twin gestations, compared with 5.03% in the singleton gestations (P<0.05). Women with twin gestations had higher rates of pregnancy induced hypertension (RR 3.65, 95% CI 2.11-6.30, P<0.05) and occurred earlier than singleton gestations (35.86±2.50 VS 37.40±1.18 weeks, P<0.05). Twin gestations with preganancy induced hypertension had significantly higher rate

Apichart Chittacharoen; Somsak Suthutvoravut

377

Ecological divergence and speciation between lemur (Eulemur) sister species in Madagascar.  

PubMed

Understanding ecological niche evolution over evolutionary timescales is crucial to elucidating the biogeographic history of organisms. Here, we used, for the first time, climate-based ecological niche models (ENMs) to test hypotheses about ecological divergence and speciation processes between sister species pairs of lemurs (genus Eulemur) in Madagascar. We produced ENMs for eight species, all of which had significant validation support. Among the four sister species pairs, we found nonequivalent niches between sisters, varying degrees of niche overlap in ecological and geographic space, and support for multiple divergence processes. Specifically, three sister-pair comparisons supported the null model that niches are no more divergent than the available background region. These findings are consistent with an allopatric speciation model, and for two sister pairs (E. collaris-E. cinereiceps and E. rufus-E. rufifrons), a riverine barrier has been previously proposed for driving allopatric speciation. However, for the fourth sister pair E. flavifrons-E. macaco, we found support for significant niche divergence, and consistent with their parapatric distribution on an ecotone and the lack of obvious geographic barriers, these findings most strongly support a parapatric model of speciation. These analyses thus suggest that various speciation processes have led to diversification among closely related Eulemur species. PMID:23865477

Blair, M E; Sterling, E J; Dusch, M; Raxworthy, C J; Pearson, R G

2013-07-19

378

Long-Term Outcome of Infants with Twin-to-Twin Transfusion Syndrome  

Microsoft Academic Search

Objective: To clarify the long-term neurodevelopmental outcome of twin-to-twin transfusion syndrome (TTTS) survivors. Methods: From January 1994 to December 2003, 33 newborns with TTTS who were derived from 18 monochorionic twin gestations were enrolled for the study. The development and growth at 3 or 6 years of age were compared between TTTS survivors and weight-matched singleton controls. Results: The mortality

Shunji Hikino; Shouichi Ohga; Takashi Kanda; Toshinori Nakashima; Junko Yamamoto; Hideki Nakayama; Hitoo Nakano; Toshiro Hara

2007-01-01

379

The TWINS Science Data System after the launch of TWINS 1  

Microsoft Academic Search

The Two Wide-angle Imaging Neutral-atom Spectrometers (TWINS) 1 satellite is in orbit and science data are expected to commence in the near future. TWINS-1 comprises half of the TWINS stereoscopic neutral atom imaging system that will advance our knowledge of the Earth's ring current. To support the expected data return, we have developed a Science Data System (SDS) for the

J. Goldstein; P. Valek; R. Skoug; D. Delapp; J. Redfern; B. Carruth; D. McComas

2007-01-01

380

Rapid Onset of Severe Twin–Twin Transfusion Syndrome Caused by Placental Venous Thrombosis  

Microsoft Academic Search

We report a case of rapid onset of severe twin–twin transfusion syndrome (TTTS) at 25 weeks gestation in a monochorionic twin\\u000a pregnancy that was uneventful before that time. Thrombosis of a main venous branch draining several arteriovenous (AV) anastomoses\\u000a to the donor changed the previous hemodynamic balance that existed between multiple bidirectional AV anastomoses. The opposing\\u000a AVs became hemodynamically uncompensated

Peter G. J. Nikkels; Martin J. C. van Gemert; Krystyna M. Sollie-Szarynska; Harry Molendijk; Bert Timmer; Geoffrey A. Machin

2002-01-01

381

Deformation twins and twinning at ambient temperature in cryomilled Al-Zn-Mg-Cu alloy powders  

Microsoft Academic Search

The nanocrystalline Al-Zn-Mg-Cu alloy powders were synthesized using cryomilling. Deformation twins and twinning at ambient temperature were observed in Al-Zn-Mg-Cu powders. Experimental results indicate that high strain rate at low temperature during cryomilling induces the formation of deformation twins by the climbing of the restricted dislocations in nano-scale grains, and the cryomilled powders at high energies and nonequilibrium state reduce

Han-bin CHEN; Jun-sheng CHENG; Bin YANG; Ji-shan ZHANG; Xiao-feng TIAN; Jian-zhong FAN

2007-01-01

382

Education and Cognitive Ability as Direct, Mediating, or Spurious Influences on Female Age at First Birth: Behavior Genetic Models Fit to Danish Twin Data1  

PubMed Central

The authors study education and cognitive ability as predictors of female age at first birth (AFB), using monozygotic and dizygotic female twin pairs from the Middle-Aged Danish Twin survey. Using mediated regression, they replicate findings linking education (and not cognitive ability) to AFB. But in a behavior genetic model, both relationships are absorbed within a latent variable measuring the shared family environment. Two interpretations are relevant. First, variance in AFB emerges from differences between families, not differences between sisters within the same family. Second, even in a natural laboratory sensitive to genetic variance in female fertility—during demographic transition—the variance in AFB was non-genetic, located instead within the shared environment.

Rodgers, Joseph Lee; Kohler, Hans-Peter; McGue, Matt; Behrman, Jere R.; Petersen, Inge; Bingley, Paul; Christensen, Kaare

2009-01-01

383

Comparison of naturally conceived and IVF-DZ twins in the Netherlands Twin Registry: a developmental study.  

PubMed

In a large set of twin pairs, we compared twins born after IVF to naturally conceived twins with respect to birth characteristics, growth, attainment of motor milestones, and emotional and behavioral problems. Twin families were registered with the Netherlands Twin Register. We included 1534 dizygotic (DZ) twins born after IVF, 5315 naturally conceived (NC) DZ twins, and 1504 control NC DZ twins who were matched to the IVF twins based on maternal age, maternal educational level, smoking during pregnancy, gestational age, and offspring sex. Data were obtained by longitudinal surveys sent to fathers, mothers, and teachers at ages 1, 2, 3, 7, 10, and 12 years. Results showed no differences in growth, in attainment of motor milestones, and in behavioral development between IVF and matched NC twins. It can be concluded that for nearly all aspects, development in IVF and NC children is similar. PMID:22132337

van Beijsterveldt, Catharina E M; Bartels, Meike; Boomsma, Dorret I

2011-11-03

384

BDNF GENE EFFECTS ON BRAIN CIRCUITRY REPLICATED IN 455 TWINS  

PubMed Central

Brain-derived neurotrophic factor (BDNF) plays a key role in learning and memory, but its effects on the fiber architecture of the living brain are unknown. We genotyped 455 healthy adult twins and their non-twin siblings (188 males/267 females; age: 23.7±2.1 years, mean±SD) and scanned them with high angular resolution diffusion tensor imaging (DTI), to assess how the BDNF Val66Met polymorphism affects white matter microstructure. By applying genetic association analysis to every 3D point in the brain images, we found that the Val-BDNF genetic variant was associated with lower white matter integrity in the splenium of the corpus callosum, left optic radiation, inferior fronto-occipital fasciculus, and superior corona radiata. Normal BDNF variation influenced the association between subjects’ performance intellectual ability (as measured by Object Assembly subtest) and fiber integrity (as measured by fractional anisotropy; FA) in the callosal splenium, and pons. The BDNF gene may affect intellectual performance by modulating white matter development. This combination of genetic association analysis and large-scale diffusion imaging directly relates a specific gene to the fiber microstructure of the living brain and to human intelligence.

Chiang, Ming-Chang; Barysheva, Marina; Toga, Arthur W.; Medland, Sarah E.; Hansell, Narelle K.; James, Michael R.; McMahon, Katie L.; de Zubicaray, Greig I.; Martin, Nicholas G.; Wright, Margaret J.; Thompson, Paul M.

2011-01-01

385

BDNF gene effects on brain circuitry replicated in 455 twins.  

PubMed

Brain-derived neurotrophic factor (BDNF) plays a key role in learning and memory, but its effects on the fiber architecture of the living brain are unknown. We genotyped 455 healthy adult twins and their non-twin siblings (188 males/267 females; age: 23.7±2.1 years, mean±SD) and scanned them with high angular resolution diffusion tensor imaging (DTI), to assess how the BDNF Val66Met polymorphism affects white matter microstructure. By applying genetic association analysis to every 3D point in the brain images, we found that the Val-BDNF genetic variant was associated with lower white matter integrity in the splenium of the corpus callosum, left optic radiation, inferior fronto-occipital fasciculus, and superior corona radiata. Normal BDNF variation influenced the association between subjects' performance intellectual ability (as measured by Object Assembly subtest) and fiber integrity (as measured by fractional anisotropy; FA) in the callosal splenium, and pons. BDNF gene may affect the intellectual performance by modulating the white matter development. This combination of genetic association analysis and large-scale diffusion imaging directly relates a specific gene to the fiber microstructure of the living brain and to human intelligence. PMID:21195196

Chiang, Ming-Chang; Barysheva, Marina; Toga, Arthur W; Medland, Sarah E; Hansell, Narelle K; James, Michael R; McMahon, Katie L; de Zubicaray, Greig I; Martin, Nicholas G; Wright, Margaret J; Thompson, Paul M

2010-12-30

386

Assessment of right ventricular function in recipient twin of twin to twin transfusion syndrome with speckle tracking echocardiography.  

PubMed

This study was undertaken to evaluate the right ventricular myocardial systolic function and its relation to the fetal volume and pressure overload in recipient twin of twin to twin transfusion syndrome with speckle tracking echocardiography. Longitudinal peak systolic strains of the right ventricle were measured by speckle tracking echocardiography in 17 patients with twin-to-twin transfusion syndrome (TTTS) and 19 normal monochorionic diamniotic pregnancies. The right ventricular free wall thickness in recipient twin (0.43 ± 0.14 cm) was significantly larger than that in the donor (0.21 ± 0.04 cm, p < 0.05) and the control group (0.18 ± 0.03 cm, p < 0.05 for larger twin and 0.17 ± 0.02 cm, p < 0.05 for smaller twin). Although there were no significant differences in the right ventricular fractional shortening and cavity area percent change among control and the TTTS groups, the absolute value of peak systolic strains of ventricular septum, right ventricular free wall and global right ventricle in recipients were all significantly lower than those of the donors and the control group. Besides, the global right ventricular peak systolic strain correlated well with gestational age adjusted right ventricular free wall thickness (r = 0.65, p = 0.04) but not with gestational age adjusted right ventricular end-diastolic dimension (r = 0.38, p = 0.28) and cavity area percent change (r = 0.33, p = 0.35). Right ventricular systolic dysfunction measured with decreased right ventricular peak systolic longitudinal strain exists despite the absence of diminished fractional shortening and cavity area percent change and this reduced systolic function correlates with the right ventricular pressure overload as shown by increased right ventricular free wall thickness. PMID:22766115

Zhao, Sheng; Deng, You-Bin; Chen, Xin-Lin; Liu, Rong

2012-07-03

387

TwinMARM: Two-stage Multiscale Adaptive Regression Methods for Twin Neuroimaging Data*  

PubMed Central

Twin imaging studies have been valuable for understanding the relative contribution of the environment and genes on brain structures and their functions. Conventional analyses of twin imaging data include three sequential steps: spatially smoothing imaging data, independently fitting a structural equation model at each voxel, and finally correcting for multiple comparisons. However, conventional analyses are limited due to the same amount of smoothing throughout the whole image, the arbitrary choice of smoothing extent, and the decreased power in detecting environmental and genetic effects introduced by smoothing raw images. The goal of this article is to develop a two-stage multiscale adaptive regression method (TwinMARM) for spatial and adaptive analysis of twin neuroimaging and behavioral data. The first stage is to establish the relationship between twin imaging data and a set of covariates of interest, such as age and gender. The second stage is to disentangle the environmental and genetic influences on brain structures and their functions. In each stage, TwinMARM employs hierarchically nested spheres with increasing radii at each location and then captures spatial dependence among imaging observations via consecutively connected spheres across all voxels. Simulation studies show that our TwinMARM significantly outperforms conventional analyses of twin imaging data. Finally, we use our method to detect statistically significant effects of genetic and environmental variations on white matter structures in a neonatal twin study.

Li, Yimei; Gilmore, John H.; Wang, Jiaping; Styner, Martin; Lin, Weili; Zhu, Hongtu

2012-01-01

388

Twin structure and structure of twin boundaries in 1–2–3-O7-? crystals  

Microsoft Academic Search

The twin and twin boundary structures of the high temperature superconductors (HTSC) 1–2–3-O7-? and La2-x Srx CuO4 systems were investigated by X-ray and electron microscopy methods. The twin parameters determined for 1–2–3-O7-? and La2-x Srx CuO4 crystals respectively are {110}\\/?110?, {100}\\/?100?. It was also shown that the twin boundaries in 1–2–3-O7-? crystals are not monoatomic planes. They are the transitional

I. M. Shmytko; V. Sh. Shekhtman; Yu. A. Ossipyan; N. S. Afonikova

1989-01-01

389

Twin–twin transfusion syndrome: cerebral ischemia is not the only fetal MR imaging finding  

Microsoft Academic Search

Background  Twin–twin transfusion syndrome (TTTS) is a complication of monochorionic\\/diamniotic twin pregnancies. An imbalance of blood\\u000a flow occurs through placental anastomoses, causing potentially significant morbidity and mortality in both twins. Although\\u000a the sonographic findings of TTTS are well documented, we believe that MR imaging is a valuable adjunct.\\u000a \\u000a \\u000a \\u000a Objective  We describe the fetal MR imaging findings associated with TTTS.\\u000a \\u000a \\u000a \\u000a Materials and methods  From

Beth M. Kline-Fath; Maria A. Calvo-Garcia; Sara M. O’Hara; Timothy M. Crombleholme; Judy M. Racadio

2007-01-01

390

TwinMARM: two-stage multiscale adaptive regression methods for twin neuroimaging data.  

PubMed

Twin imaging studies have been valuable for understanding the relative contribution of the environment and genes on brain structures and their functions. Conventional analyses of twin imaging data include three sequential steps: spatially smoothing imaging data, independently fitting a structural equation model at each voxel, and finally correcting for multiple comparisons. However, conventional analyses are limited due to the same amount of smoothing throughout the whole image, the arbitrary choice of smoothing extent, and the decreased power in detecting environmental and genetic effects introduced by smoothing raw images. The goal of this paper is to develop a two-stage multiscale adaptive regression method (TwinMARM) for spatial and adaptive analysis of twin neuroimaging and behavioral data. The first stage is to establish the relationship between twin imaging data and a set of covariates of interest, such as age and gender. The second stage is to disentangle the environmental and genetic influences on brain structures and their functions. In each stage, TwinMARM employs hierarchically nested spheres with increasing radii at each location and then captures spatial dependence among imaging observations via consecutively connected spheres across all voxels. Simulation studies show that our TwinMARM significantly outperforms conventional analyses of twin imaging data. Finally, we use our method to detect statistically significant effects of genetic and environmental variations on white matter structures in a neonatal twin study. PMID:22287236

Li, Yimei; Gilmore, John H; Wang, Jiaping; Styner, Martin; Lin, Weili; Zhu, Hongtu

2012-01-24

391

A disclination model for the twin-twin intersection and the formation of diamond-hexagonal silicon and germanium  

Microsoft Academic Search

A twin-twin intersection mechanism for twinning in semiconductors is presented. The mechanism is based on the disclination character of twins and accounts for all experimental findings including the diamond-hexagonal structure, the twin\\/matrix orientation relationship, and the shape of the intersected volume, as well as irregularities within the transformed region such as stacking faults and diamond cubic bands. The formation of

P. Müllner; P. Pirouz

1997-01-01

392

The kinetics and energetics of dislocation mediated de-twinning in nano-twinned face-centered cubic metals  

Microsoft Academic Search

Polycrystalline Cu with hierarchy microstructures – ultrafined grains about 500nm and included twins several to tens of nanometers thick – show maximum strength at an averaged twin thickness of 15nm. Li et al. Nature 464 (2010) 877–880 (Ref. [1]), reported that the primary plastic deformation transits from inclined dislocation gliding to de-twinning in nano-twinned (nt) Cu when twin thicknesses decrease

Yujie Wei

2011-01-01

393

Monozygotic twins concordant for autism and hyperlexia.  

PubMed

The authors describe male monozygotic twins, Jon and Jay, who are concordant for autism and hyperlexia. Autism and mental retardation were diagnosed at the age of 2 years 5 months. Jay was the more advanced twin in motor co-ordination, attention span and receptive abilities, but had frequent tantrums. When psychologically assessed at 7 years 2 months, Jon showed borderline/severe mental retardation on the measure of non-verbal intelligence and Jay was moderately retarded. Their receptive language age was greater than their expressive language age: Jon's speech was less mature but more communicative and Jay's was perseverative and ritualistic. Even though Jon was the more mentally retarded twin, Jay was the more autistic in some behavioral aspects. These twins highlight the relationship between autism and hyperlexia. PMID:3169393

Smith, I M; Bryson, S E

1988-08-01

394

Resemblance of Tongue Anatomy in Twins  

PubMed Central

This study compared the anatomical features of the tongue in nine pairs of twins — six monozygotic and three dizygotic. The aim of the project was to determine if tongues, like any other anatomical structure, could be used to reliably predict relatedness given that tongue shape, presentation and surface can be influenced by environment. Using the method of forced choice, 30 subjects were asked to match the photographs of tongues from twins. Our data indicate that, based on visual assessment, monozygotic twins have highly similar tongues (60% matches); similarly, dizygotic twins were matched 31% of the time, which is a higher probability than would be expected from random selection. This study should help identify baseline and control data in future behavioral studies of taste, which has a genetic basis.

Spielman, Andrew I.; Brand, Joseph G.; Buischi, Yvonne; Bretz, Walter A.

2011-01-01

395

Diabetes and Menopause: A Twin Challenge  

MedlinePLUS

Diabetes Basics In-Depth Multimedia Expert Answers Expert Blog Resources What's New Reprints A single copy of ... may be reprinted for personal, noncommercial use only. Diabetes and menopause: A twin challenge By Mayo Clinic ...

396

Twin tower distillation of crude oil  

Microsoft Academic Search

A sequential twin tower fractionation arrangement for separating crude oil is described which is particularly concerned with lowering fractionation heat requirements in conjunction with reducing steam utilization in the combination operation.

R. I. Graham; J. R. Mcclernon; A. M. Peiser

1980-01-01

397

Resemblance of tongue anatomy in twins.  

PubMed

This study compared the anatomical features of the tongue in nine pairs of twins - six monozygotic and three dizygotic. The aim of the project was to determine if tongues, like any other anatomical structure, could be used to reliably predict relatedness given that tongue shape, presentation and surface can be influenced by environment. Using the method of forced choice, 30 subjects were asked to match the photographs of tongues from twins. Our data indicate that, based on visual assessment, monozygotic twins have highly similar tongues (60% matches); similarly, dizygotic twins were matched 31% of the time, which is a higher probability than would be expected from random selection. This study should help identify baseline and control data in future behavioral studies of taste, which has a genetic basis. PMID:21623658

Spielman, Andrew I; Brand, Joseph G; Buischi, Yvonne; Bretz, Walter A

2011-06-01

398

Shock Driven Twinning in Tantalum Single Crystals  

SciTech Connect

Recovery based observations of high pressure material behavior generated under high explosively driven flyer based loading conditions are reported. Two shock pressures, 25, and 55 GPa and four orientations {l_brace}(100), (110), (111), (123){r_brace} were considered. Recovered material was characterized using electron backscatter diffraction along with a limited amount of transmission electron microscopy to assess the occurrence of twinning under each test condition. Material recovered from 25 GPa had a very small fraction of twinning for the (100), (110), and (111) oriented crystals while a more noticeable fraction of the (123) oriented crystal was twinned. Material recovered from 55 GPa showed little twinning for (100) orientation slightly more for the (111) orientation and a large area fraction for the (123) orientation. The EBSD and TEM observations of the underlying deformation substructure are rationalized by comparing with previous static and dynamic results.

McNaney, J M; HSUING, L M; Barton, N R; Kumar, M

2009-07-20

399

Expansion and division of conjoined twins  

Microsoft Academic Search

Omphalopagus conjoined twins were born by cesarean section after their 24-year-old gravida 2, para 1 mother went into labor at 35 weeks' gestation. Initial studies included roentenograms, an upper gastrointestinal study, small bowel follow-through, and computerized tomography with intravenous contrast from neck through pelvis. Results of these studies showed that the twins had very little shared vasculature, but did share

M. L Hilfiker; M Hart; R Holmes; M Cooper; J Kriett; D Collins; M Allshouse

1998-01-01

400

Twin roll casting of aluminum alloy strips  

Microsoft Academic Search

Two kinds of twin roll caster for aluminum alloys were devised in the present study. Vertical type was adopted. The strip, which was thinner than 3mm, could be cast at speeds higher than 60m\\/min. Aluminum alloy, which freezing zone is very wide like A5182, could be cast using the twin roll caster of the present study at speeds up to

Toshio Haga; Kenta Tkahashi; Masaaki Ikawaand; Hisaki Watari

2004-01-01

401

Twinning and Slip in Zinc by Indentation  

Microsoft Academic Search

Observations of twinning and slip deformation caused by indentation of zinc reveal that extensive slip on the basal and second-order pyramidal systems takes place at loads up to 5 kg. Prismatic punching through 1-cm crystals is observed at indentation loads in excess of about 2.5 kg. It is concluded that the stress at the tip of the twins cannot be

R. C. Blish II; T. Vreeland Jr.

1968-01-01

402

The Twin Research Registry at SRI International.  

PubMed

The Twin Research Registry (TRR) at SRI International is a community-based registry of twins established in 1995 by advertising in local media, mainly on radio stations and in newspapers. As of August 2012, there are 3,120 same- and opposite-sex twins enrolled; 86% are 18 years of age or older (mean age 44.9 years, SD 16.9 years) and 14% less than 18 years of age (mean age 8.9 years, SD 4.5); 67% are female, and 62% are self-reported monozygotic (MZ). More than 1,375 twins have participated in studies over the last 15 years in collaboration with the University of California Medical Center in San Francisco, the University of Texas MD Anderson Cancer Center, and the Stanford University School of Medicine. Each twin completes a registration form with basic demographic information either online at the TRR Web site or during a telephone interview. Contact is maintained with members by means of annual newsletters and birthday cards. The managers of the TRR protect the confidentiality of twin data with established policies; no information is given to other researchers without prior permission from the twins; and all methods and procedures are reviewed by an Institutional Review Board. Phenotypes studied thus far include those related to nicotine metabolism, mutagen sensitivity, pain response before and after administration of an opioid, and a variety of immunological responses to environmental exposures, including second-hand smoke and vaccination for seasonal influenza virus and Varicella zoster virus. Twins in the TRR have participated in studies of complex, clinically relevant phenotypes that would not be feasible to measure in larger samples. PMID:23084148

Krasnow, Ruth E; Jack, Lisa M; Lessov-Schlaggar, Christina N; Bergen, Andrew W; Swan, Gary E

2012-10-19

403

Silicic Eruptions of the Past 50 kyr at the Three Sisters Volcanic Cluster  

NASA Astrophysics Data System (ADS)

The Three Sisters volcanic cluster in the central Oregon Cascades consists of mafic to intermediate stratovolcanoes surrounded by mafic and silicic flows and domes. The bulk of South and Middle Sister are late Pleistocene while North Sister is middle Pleistocene (Schmidt and Grunder, 2003 GSA abs.). Thick rhyolite and dacite lava flows and domes are rich in potassium, and young glaciation exposes holocrystalline groundmass textures ideal for argon geochronology. Several of these silicic flows bracket stratovolcano growth, and precise geochronology illuminates a rich basalt to rhyolite history in the cluster over the past 50 kyr. Careful step-heating 40Ar/39Ar experiments yield excellent plateau ages with radiogenic yields often above 5% on rocks as young as 20 ka. Most samples have well-determined isochrons with atmospheric (40/36 = 295.5) intercepts, although several have intercepts as low as 286. South Sister is a composite cone with an andesite/dacite base (Hodge Crest) and a young andesite summit sequence. The basal flow of the 300m-thick, youngest conformable stack of andesite lavas at the summit is 27+/-3 ka. Unconformably underlying portions date back to at least 50 ka based on ages of overlapping silicic flows. The base of Middle Sister is andesite overlain by ˜300m of olivine basalt. Some Middle Sister andesites and all basalts overlie a distinctive dacite agglutinate (20+/-2 ka) in the South/Middle Sister saddle. All Middle Sister lavas underlie a thick dacite flow (14+/-3 ka) that vented at 8500 ft (2600m) on its S flank. Dacite lava flows erupted from the Middle/North Sister saddle at 27+/-2 and 18+/-2 ka. Additionally, several >100m-thick rhyolite and dacite lavas vented low on the flanks of the cluster. Obsidian Cliff rhyolite (37.8+/-1.8 ka) and Lane Plateau dacite (21.4+/-1.9 ka) erupted W of Middle Sister, the Dew Lake dacite (32.3+/-1.8 ka) located near the locus of the INSAR anomaly W of South Sister flowed around a 148+/-4 ka (knob 6482) basalt and near the 149+/-5 ka (The Husband), 159+/-10 ka (Upper Mesa Creek) and 279+/-6 ka (The Sphinx) basalts. The south flank of South Sister is dominated by the late Holocene rhyolites of Rock Mesa and the Devil's Hill chain and about ten 24-50 ka rhyolite and dacite domes and flows. A 100m-thick 35+/-2 ka rhyolite lava also extends NE from South Sister into Squaw Creek. In sum, South and Middle Sisters are mafic to intermediate and their youngest activity is coeval. Silicic flows on and around the volcanic cluster are voluminous, abundant and young.

Calvert, A. T.; Hildreth, W.; Fierstein, J.

2003-12-01

404

Twin-core fiber optical tweezers.  

PubMed

We present an abruptly tapered twin-core fiber optical tweezers, which is fabricated by fusing and drawing the twin-core fiber. In the twin-core fiber, the two beams are guided by the tapered fiber. At the end of the fiber tip, a larger converge angle between the two beams are made due to the abrupt tapered shape, which is formed a fast divergent optical field. The microscopic particle trapping performance of this special designed tapered twin-core fiber tip is investigated. The functionality of the proposed novel twin-core fiber optical tweezers is extended since an in-fiber integrated Mach-Zehnder interferometer has been used to control orientation of the trapped particle. The distribution of the optical field emerging from the tapered fiber tip is simulated based on the beam propagation method (BPM). By using this two-beam combination technique, a strong enough gradient forces well is obtained for microscopic particles trapping in three dimensions. The abruptly tapered twin-core fiber optical tweezers is rigid and easy to handle, especially useful for building up a multi-tweezers system for trapping and manipulating micro-scale particles. PMID:18542553

Yuan, Libo; Liu, Zhihai; Yang, Jun; Guan, Chunying

2008-03-31

405

Ionospheric response to traveling convection twin vortices  

SciTech Connect

Traveling convection twin vortices have been observed for several years. At ionospheric altitudes, the twin vortices correspond to spatially localized, transient structures embedded in a large-scale background convection pattern. The convection vortices are typically observed in the morning and evening regions. They are aligned predominantly in the east-west direction and have a horizontal extent of from 500-1000 km. Associated with the twin vortices are enhanced electric fields, particle precipitation, and an upward/downward field-aligned current pair. Once formed, the twin vortex structures propagate in the tailward direction at speeds of several km/s, but they weaken as they propagate and only last for about 10-20 minutes. Because these convection structures might have a significant effect on the localized ionosphere, the USU ionospheric model was used to calculate the response of the ionosphere to {open_quotes}representative{close_quotes} traveling convection twin vortices for a range of background conditions. The ionospheric response includes localized temperature enhancements, ion composition changes, non-Maxwellian ion distributions, and plasma upwelling events. The response is transient and the magnitude of the response depends on the background ionosphere conditions and on the characteristics of the twin vortices. 17 refs., 4 figs.

Schunk, R.W.; Zhu, L.; Sojka, J.J. [Utah State Univ., Logan, UT (United States)

1994-08-15

406

Intraventricular twin fetuses in fetu.  

PubMed

The authors report a rare case of multiple intracranial fetuses in fetu, fulfilling Willis' traditional criteria, which include an axial and appendicular skeleton with surrounding organized tissue. This case was ascertained from studies of a full-term female neonate who presented with ventriculomegaly. A CT scan showed intracranial calcifications that were suggestive of an axial skeleton. Her birth weight was 3.176 kg (50th-75th percentile), length was 52 cm (90th percentile), head circumference was 35 cm (50th-75th percentile), and Apgar scores were 7 and 8 at 1 and 5 minutes, respectively. Prenatal ultrasonography studies performed at 12 weeks and 5 days, and 19 weeks and 6 days revealed normal findings. A 37-week prenatal ultrasonography study showed ventriculomegaly and obstructive hydrocephalus, with a possible intracranial teratoma. Cranial imaging at birth with ultrasonography, CT and MR imaging, and MR angiography demonstrated 2 complex intraventricular masses with cystic, solid, and bony elements. A craniotomy with resection of the masses was performed at 3 months of age. The infant survived and is now 12 months old with some developmental progress. Two axial skeletons, with accompanying rib cage and extremities, including well-formed feet and toes, were noted. Both anencephalic structures had skin with hair, fat, skeletal and smooth muscle, and bony structures with bone marrow and focal areas of calcification. Multiple viscera were present and included thymus, bowel, stomach, salivary gland, kidney, adrenal gland, lung, and presumed adnexal structures. A diagnosis of fetuses in fetu was rendered. Chromosomal studies of the child and tissue from the 2 fetuses in fetu showed normal female karyotypes. A single nucleotide polymorphism array analysis from the proband infant and tissue from the 2 identified fetuses in fetu appeared to be genetically identical. These results are consistent with a monozygotic twin embryonic origin of the fetus in fetu tissue, which is a mechanism that has been suggested in previous reports in which karyotypes, blood types, and limited genetic loci have been studied. This is the first report of a rare example of intracranial intraventricular twin fetuses in fetu for which a genome-wide single nucleotide polymorphism assay has confirmed their genetic identity. PMID:22208315

Huddle, Lauren N; Fuller, Christine; Powell, Tiffany; Hiemenga, Judith A; Yan, Jia; Deuell, Brian; Lyders, Eric M; Bodurtha, Joann N; Papenhausen, Peter R; Jackson-Cook, Colleen K; Pandya, Arti; Jaworski, Margie; Tye, Gary W; Ritter, Ann M

2012-01-01

407

Special twin environments, genetic influences and their effects on the handedness of twins and their siblings.  

PubMed

It has been suggested that twinning may influence handedness through the effects of birth order, intra-uterine crowding and mirror imaging. The influence of these effects on handedness (for writing and throwing) was examined in 3657 Monozygotic (MZ) and 3762 Dizygotic (DZ) twin pairs (born 1893-1992). Maximum likelihood analyses revealed no effects of birth order on the incidence of left-handedness. Twins were no more likely to be left-handed than their singleton siblings (n = 1757), and there were no differences between the DZ co-twin and sibling-twin covariances, suggesting that neither intra-uterine crowding nor the experience of being a twin affects handedness. There was no evidence of mirror imaging; the co-twin correlations of monochorionic and dichorionic MZ twins did not differ. Univariate genetic analyses revealed common environmental factors to be the most parsimonious explanation of familial aggregation for the writing-hand measure, while additive genetic influences provided a better interpretation of the throwing hand data. PMID:12723998

Medland, Sarah E; Wright, Margaret J; Geffen, Gina M; Hay, David A; Levy, Florence; Martin, Nicholas G; Duffy, David L

2003-04-01

408

Deformation twinning mechanisms in FCC and HCP metals  

SciTech Connect

We report the recent work on twinning and detwinning in fcc and hcp metals based on the in situ and ex situ TEM observations and molecular dynamics simulations. Three aspects are discussed in this paper. (1) Detwinning in single-phase Cu with respect to growth twins, (2) deformation twinning in Ag-Cu composites, and (3) deformation twinning mechanisms in hcp metals. The main conclusion is that atomic structures of interfaces (twin boundaries, two-phases interface, and grain boundaries) play a crucial role in nucleating and propagating of deformation twins.

Wang, Jian [Los Alamos National Laboratory; Tome, Carlos N [Los Alamos National Laboratory; Beyerlein, Irene J [Los Alamos National Laboratory; Misra, Amit [Los Alamos National Laboratory; Mara, N [Los Alamos National Laboratory

2011-01-31

409

Confined Blood Chimerism in Monochorionic Dizygotic Twins Conceived Spontaneously  

PubMed Central

Traditionally, monochorionicity has been regarded as synonymous with monozygosity. However, several recent cases of monochorionic dizygotic twins have shown that monochorionic twins can be dizygous. We report a rare case of monochorionic diamnionic, gender-discordant twins who were conceived spontaneously. Initially, a monochorionic placenta was diagnosed by ultrasonography at 8 weeks of gestation and then confirmed by pathology after delivery. The twins had different genders. A comparison of cytogenetic analyses using peripheral blood lymphocytes and skin fibroblasts revealed that chimerism was confined to blood cells. We have experienced two cases of monochorionic dizygotic twins since 2003. These cases suggest that monochorionic dizygotic twins are not as rare as previously thought.

Kanda, Takashi; Ogawa, Masanobu; Sato, Kazuo

2013-01-01

410

A role for GPN-loop GTPase yGPN1 in sister chromatid cohesion.  

PubMed

Sister chromatid cohesion and separation, involving the cohesin complex, are crucial for accurate inheritance of genetic information. This complex is also fundamental for efficient post-replicative repair of DNA double-strand breaks and has a key role in the mechanisms of gene transcription control. Cohesin is subjected to many post-translational modifications but the regulators implicated in the control of its activity have been poorly described. Here, we show that the conserved and essential GPN loop GTPase yGPN1 in Saccharomyces cerevisiae is involved in sister chromatid cohesion mechanisms. Based on a sister chromatid cohesion assay, we found that over-expression of the yGPN1 gene promotes sister chromatid separation during anaphase. The sharp slowdown in progression of the S phase observed in cells where yGPN1 expression is down-regulated strongly suggests that yGPN1 is necessary for DNA replication. Moreover, analysis of yGPN1 protein-protein interaction network highlights the yGPN1 links with DNA replication, sister chromatid cohesion/separation and the gene expression process. PMID:21532343

Alonso, Béatrice; Chaussinand, Guylaine; Armengaud, Jean; Godon, Christian

2011-06-01

411

Neuropsychological profiles of three sisters homozygous for the fragile X premutation  

SciTech Connect

Fragile X syndrome (fraX) is associated with an amplification of a CGG repeat within the fraX mental retardation (FMR-1) gene. We describe an exceptional family in which 3 adult sisters are homozygous for the FMR-1 premutation. Each sister inherited 2 premutation alleles (ca. 80 CGG repeats) from their biologically unrelated parents. The 3 sisters were administered measures of executive function, visual spatial, memory, and verbal skills. Deficiencies in the first 2 of these domains have been reported among females with the full mutation. The sisters` performances were compared with available normative data and with published group means for females affected by fraX. These women did not appear to have verbal or memory difficulties. None of the women demonstrated a global executive function deficit, and none had global deficits in spatial ability. The profiles of these sisters are consistent with reports that the fragile X premutation does not affect cognitive performance. 31 refs., 1 fig., 4 tabs.

Mazzocco, M.M.M. [Johns Hopkins School of Medicine, Baltimore, MD (United States); Holden, J.J.A. [Ongwanada Resource Centre, Kingston, Ontario (Canada)

1996-08-09

412

Mps1 kinase promotes sister-kinetochore bi-orientation by a tension-dependent mechanism.  

PubMed

Segregation of sister chromatids to opposite spindle poles during anaphase is dependent on the prior capture of sister kinetochores by microtubules extending from opposite spindle poles (bi-orientation). If sister kinetochores attach to microtubules from the same pole (syntelic attachment), the kinetochore-spindle pole connections must be re-oriented to be converted to proper bi-orientation. This re-orientation is facilitated by Aurora B kinase (Ipl1 in budding yeast), which eliminates kinetochore-spindle pole connections that do not generate tension. Mps1 is another evolutionarily conserved protein kinase, required for spindle-assembly checkpoint and, in some organisms, for duplication of microtubule-organizing centers. Separately from these functions, however, Mps1 has an important role in chromosome segregation. Here we show that, in budding yeast, Mps1 has a crucial role in establishing sister-kinetochore bi-orientation on the mitotic spindle. Failure in bi-orientation with inactive Mps1 is not due to a lack of kinetochore-spindle pole connections by microtubules, but due to a defect in properly orienting the connections. Mps1 promotes re-orientation of kinetochore-spindle pole connections and eliminates those that do not generate tension between sister kinetochores. We did not find evidence that Ipl1 regulates Mps1 or vice versa; therefore, they play similar, but possibly independent, roles in facilitating bi-orientation. PMID:18060784

Maure, Jean-François; Kitamura, Etsushi; Tanaka, Tomoyuki U

2007-11-29

413

Acardiac amorphous twin with prune belly sequence in the co-twin.  

PubMed

We describe a twin with acardia acephalus or "Twin Reversed Arterial Perfusion Sequence" and prune belly sequence in the co-twin. In a former quite similar case a prune belly appearance of the co-twin of an acardiac fetus was found to be secondary to the ascites caused by cardiac failure. In the present case, we are dealing with the prune belly sequence as a separate condition, given the fact there were no signs of ascites or cardiac failure. We also found associated anomalies: agenesis of the left ureter and kidney, dysplastic right kidney and anal atresia. Urinary tract obstruction has never been described in the co-twin of an acardiac amorphous fetus. PMID:1877624

Buntinx, I M; Bourgeois, N; Buytaert, P M; Dumon, J E

1991-06-15

414

Sabinas syndrome in monozygotic twins.  

PubMed

A pair of 2-year-old female monozygotic twins presented with short and brittle hair. There was marked reduction in hair density, and excessive curving of the eyelashes. Onychodystrophy was also evident. They also had developmental delay in verbal and motor skills. Neither their parents nor other relatives were known to be affected, and there was no history of consanguinity. Examination of the hair shaft under light microscopy showed trichoschisis, which was more evident under electron microscopy. Under polarized light, the hair shafts showed the pathognomonic 'tiger-tail' pattern. The level of sulphur in the hair was low. Both patients were negative for TTDN1 mutation. Clinical correlation was performed and the diagnosis of Sabinas syndrome was made. Sabinas syndrome is a very rare autosomal recessive disorder first described in a group of patients from a small community in north-eastern Mexico. It is diagnosable at birth, and its major symptoms include brittle hair, mental retardation and nail dysplasia. Structural hair abnormalities are seen by both light and electron microscopy. PMID:19438561

López-García, D R; Salas-Alanis, J C; Christiano, A M; Ocampo-Candiani, J; Gómez-Flores, M

2009-05-05

415

The Project TALENT Twin and Sibling Study.  

PubMed

Project TALENT is a US national longitudinal study of about 377,000 individuals born in 1942-1946, first assessed in 1960. Students in about 1,200 schools participated in a 2-day battery covering aptitudes, abilities, interests, and individual and family characteristics (Flanagan, 1962; www.projectTALENT.org). Follow-up assessments 1, 5, and 11 years later assessed educational and occupational outcomes. The sample includes approximately 92,000 siblings from 40,000 families, including 2,500 twin pairs and 1,200 other siblings of twins. Until recently, almost no behavior genetic research has been conducted with the sample. In the original data collection information was not collected with the intent to link family members. Recently, we developed algorithms using names, addresses, birthdates, and information about family structure to link siblings and identify twins. We are testing several methods to determine zygosity, including use of yearbook photographs. In this paper, we summarize the design and measures in Project TALENT, describe the Twin and Sibling sample, and present our twin-sib-classmate model. In most twin and family designs, the 'shared environment' includes factors specific to the family combined with between-family differences associated with macro-level variables such as socioeconomic status. The school-based sampling design used in Project TALENT provides a unique opportunity to partition the shared environment into variation shared by siblings, specific to twins, and associated with school- and community-level factors. The availability of many measured characteristics on the family, schools, and neighborhoods enhances the ability to study the impact of specific factors on behavioral variation. PMID:23101474

Prescott, Carol A; Achorn, Deanna Lyter; Kaiser, Ashley; Mitchell, Lindsey; McArdle, John J; Lapham, Susan J

2012-10-29

416

Frequent and Efficient Use of the Sister Chromatid for DNA Double-Strand Break Repair during Budding Yeast Meiosis  

PubMed Central

Recombination between homologous chromosomes of different parental origin (homologs) is necessary for their accurate segregation during meiosis. It has been suggested that meiotic inter-homolog recombination is promoted by a barrier to inter-sister-chromatid recombination, imposed by meiosis-specific components of the chromosome axis. Consistent with this, measures of Holliday junction–containing recombination intermediates (joint molecules [JMs]) show a strong bias towards inter-homolog and against inter-sister JMs. However, recombination between sister chromatids also has an important role in meiosis. The genomes of diploid organisms in natural populations are highly polymorphic for insertions and deletions, and meiotic double-strand breaks (DSBs) that form within such polymorphic regions must be repaired by inter-sister recombination. Efforts to study inter-sister recombination during meiosis, in particular to determine recombination frequencies and mechanisms, have been constrained by the inability to monitor the products of inter-sister recombination. We present here molecular-level studies of inter-sister recombination during budding yeast meiosis. We examined events initiated by DSBs in regions that lack corresponding sequences on the homolog, and show that these DSBs are efficiently repaired by inter-sister recombination. This occurs with the same timing as inter-homolog recombination, but with reduced (2- to 3-fold) yields of JMs. Loss of the meiotic-chromosome-axis-associated kinase Mek1 accelerates inter-sister DSB repair and markedly increases inter-sister JM frequencies. Furthermore, inter-sister JMs formed in mek1? mutants are preferentially lost, while inter-homolog JMs are maintained. These findings indicate that inter-sister recombination occurs frequently during budding yeast meiosis, with the possibility that up to one-third of all recombination events occur between sister chromatids. We suggest that a Mek1-dependent reduction in the rate of inter-sister repair, combined with the destabilization of inter-sister JMs, promotes inter-homolog recombination while retaining the capacity for inter-sister recombination when inter-homolog recombination is not possible.

Goldfarb, Tamara; Lichten, Michael

2010-01-01

417

Does mode of delivery alters the perinatal outcome in uncomplicated monochorionic diamniotic twin gestation (MCDA) in comparison to dichorionic diamniotic twin gestation (DCDA): 5 year data  

Microsoft Academic Search

AimsTo compare the mode of delivery and perinatal outcome in monochorionic diamniotic twin gestation (MCDA) twins with dichorionic diamniotic twin gestation (DCDA) twins after 26 weeks gestation.MethodsDelivery and neonatal outcome data was retrieved from medical records of 227 sets of DCDA twins and 36 sets of MCDA twins (2003–2008).ResultsData from 16 sets of twins in DCDA and two sets of

M Mehta; K Cornthwaite; A Sau

2011-01-01

418

The interaction between slip and twinning systems and the influence of twinning on the mechanical behavior of fcc metals and alloys  

Microsoft Academic Search

The analysis of twin-slip and twin-twin interactions in fcc crystals is reviewed using the method proposed by Sleeswyk and\\u000a Verbraak for the interactions between bcc twins. Slip or twinning dislocations impinging a twin boundary can generally be\\u000a incorporated into the obstacle twin through often unfavorable dislocation reactions. Transmission electron microscopy observations\\u000a are in agreement with the predicted mechanisms of stress

L. Rémy

1981-01-01

419

Separase: a universal trigger for sister chromatid disjunction but not chromosome cycle progression  

PubMed Central

Separase is a protease whose liberation from its inhibitory chaperone Securin triggers sister chromatid disjunction at anaphase onset in yeast by cleaving cohesin's kleisin subunit. We have created conditional knockout alleles of the mouse Separase and Securin genes. Deletion of both copies of Separase but not Securin causes embryonic lethality. Loss of Securin reduces Separase activity because deletion of just one copy of the Separase gene is lethal to embryos lacking Securin. In embryonic fibroblasts, Separase depletion blocks sister chromatid separation but does not prevent other aspects of mitosis, cytokinesis, or chromosome replication. Thus, fibroblasts lacking Separase become highly polyploid. Hepatocytes stimulated to proliferate in vivo by hepatectomy also become unusually large and polyploid in the absence of Separase but are able to regenerate functional livers. Separase depletion in bone marrow causes aplasia and the presumed death of hematopoietic cells other than erythrocytes. Destruction of sister chromatid cohesion by Separase may be a universal feature of mitosis in eukaryotic cells.

Wirth, Karin G.; Wutz, Gordana; Kudo, Nobuaki R.; Desdouets, Chantal; Zetterberg, Anders; Taghybeeglu, Shahryar; Seznec, Janina; Ducos, Germain M.; Ricci, Romeo; Firnberg, Nicole; Peters, Jan-Michael; Nasmyth, Kim

2006-01-01

420

Three sisters with Chiari I malformation with and without associated syringomyelia.  

PubMed

Two daughters of non-consanguineous Ashkenazi Jewish parentage presented with occipital headaches in the second decade of life. Each had a symptomatic Chiari I malformation (CMI) and a large cervicothoracic syrinx. A third sister was diagnosed as having CMI without syrinx after MR screening of first-degree relatives. A fourth (the eldest) sister was asymptomatic and did not have CMI or syrinx. The girls' mother had platybasia on screening MR and a history of cough headaches. All four sisters also had demonstrable platybasic features on MR. The girls' father was asymptomatic and radiologically normal. This family represents the first reported case of three siblings in one family with confirmed CMI with or without syrinx. We discuss the possible genetic and mechanical mechanisms for the development of these abnormalities in this family. PMID:17992048

Weisfeld-Adams, James D; Carter, Michael R; Likeman, Marcus J; Rankin, Julia

2007-01-01

421

Sororin is a master regulator of sister chromatid cohesion and separation  

PubMed Central

The maintenance of sister chromatid cohesion from S phase to the onset of anaphase relies on a small but evolutionarily conserved protein called Sororin. Sororin is a phosphoprotein and its dynamic localization and function are regulated by protein kinases, such as Cdk1/cyclin B and Erk2. The association of Sororin with chromatin requires cohesin to be preloaded to chromatin and modification of Smc3 during DNA replication. Sororin antagonizes the function of Wapl in cohesin releasing from S to G2 phase and promotes cohesin release from sister chromatid arms in prophase via interaction with Plk1. This review focuses on progress of the identification and regulation of Sororin during cell cycle; role of post-translational modification on Sororin function; role of Sororin in the maintenance and resolution of sister chromatid cohesion; and finally discusses Sororin’s emerging role in cancer and the potential issues that need be addressed in the future.

Zhang, Nenggang; Pati, Debananda

2012-01-01

422

Brothers delay menarche and the onset of sexual activity in their sisters  

PubMed Central

The higher costs of sons compared with daughters extends to a negative effect of brothers on the lifetime reproductive success of their siblings in subsistence and preindustrial societies. In societies with fewer resource constraints, one might expect that these effects would be limited or non-existent. This study investigates the costs of brothers and sisters in a contemporary western society of adult Australians. Girls with elder brothers had a delayed age at menarche. Younger brothers were associated with delayed onset of sexual activity in sisters, but not in brothers. Neither younger nor elder brothers influenced fitness parameters (number of pregnancies, number of children, age at first pregnancy or age at first birth) in siblings of either sex. This study provides evidence that brothers negatively affect their sisters' onset of reproductive maturity and sexual activity; however, this delay is not associated with a fitness cost in contemporary Australia. We suggest this is due to the long period of independence prior to child bearing.

Milne, Fritha H.; Judge, Debra S.

2011-01-01

423

Separase: a universal trigger for sister chromatid disjunction but not chromosome cycle progression.  

PubMed

Separase is a protease whose liberation from its inhibitory chaperone Securin triggers sister chromatid disjunction at anaphase onset in yeast by cleaving cohesin's kleisin subunit. We have created conditional knockout alleles of the mouse Separase and Securin genes. Deletion of both copies of Separase but not Securin causes embryonic lethality. Loss of Securin reduces Separase activity because deletion of just one copy of the Separase gene is lethal to embryos lacking Securin. In embryonic fibroblasts, Separase depletion blocks sister chromatid separation but does not prevent other aspects of mitosis, cytokinesis, or chromosome replication. Thus, fibroblasts lacking Separase become highly polyploid. Hepatocytes stimulated to proliferate in vivo by hepatectomy also become unusually large and polyploid in the absence of Separase but are able to regenerate functional livers. Separase depletion in bone marrow causes aplasia and the presumed death of hematopoietic cells other than erythrocytes. Destruction of sister chromatid cohesion by Separase may be a universal feature of mitosis in eukaryotic cells. PMID:16533945

Wirth, Karin G; Wutz, Gordana; Kudo, Nobuaki R; Desdouets, Chantal; Zetterberg, Anders; Taghybeeglu, Shahryar; Seznec, Janina; Ducos, Germain M; Ricci, Romeo; Firnberg, Nicole; Peters, Jan-Michael; Nasmyth, Kim

2006-03-13

424

Using a sibling design to compare childhood adversities in female patients with BPD and their sisters.  

PubMed

Abuse and neglect are well-established risk correlates of borderline personality disorder (BPD). The goal of this study was to examine whether BPD probands can be differentiated from their sisters with respect to a range of developmental adversity and maltreatment indicators, including retrospective self-reports of past experiences of childhood abuse and neglect, dysfunctional parent-child relationships and peer victimization and dysfunctional peer relationships. A total of 53 patients with BPD were compared to 53 sisters who were currently free of psychopathology on measures assessing childhood adversities. Both probands and sisters reported similar prevalence of intrafamilial abuse, although BPD patients reported more severe physical and emotional abuse. BPD patients reported higher prevalence of physical abuse by peers. These findings generally support the principle of multifinality, in which similar histories of adversities can be associated with a variety of outcomes, ranging from psychopathology to resilience. PMID:23076835

Laporte, Lise; Paris, Joel; Guttman, Herta; Russell, Jennifer; Correa, José A

2012-10-16

425

Yoruba customs and beliefs pertaining to twins.  

PubMed

The Yoruba are an important ethnic group mainly occupying Southwestern Nigeria. Mainly for genetic reasons, this very large tribe happens to present the highest dizygotic twinning rate in the world (4.4 % of all maternities). The high perinatal mortality rate associated with such pregnancies has contributed to the integration of a special twin belief system within the African traditional religion of this tribe. The latter is based on the concept of a supreme deity called Olodumare or Olorun, assisted by a series of secondary gods (Orisha) while Yoruba religion also involves immortality and reincarnation of the soul based on the animistic cult of ancestors. Twins are therefore given special names and believed to detain special preternatural powers. In keeping with their refined artistic tradition, the Yoruba have produced numerous wooden statuettes called Ibejis that represent the souls of deceased newborn twins and are involved in elaborate rituals. Among Yoruba traditional beliefs and lore some twin-related themes are represented which are also found in other parts of the world. Basic features of the original Yoruba beliefs have found their way into the religious traditions of descendants of African slaves imported in the West Indies and in South America. PMID:11931691

Leroy, Fernand; Olaleye-Oruene, Taiwo; Koeppen-Schomerus, Gesina; Bryan, Elizabeth

2002-04-01

426

Substantial genetic link between IQ and working memory: implications for molecular genetic studies on schizophrenia. the European twin study of schizophrenia (EUTwinsS).  

PubMed

While evidence is accumulating to support specific neurocognitive deficits as putative endophenotypes for schizophrenia, the heritability of these deficits in healthy subjects and whether they share common genetic influences, is not well established. In the present study, 529 healthy adult twins from two centers within the European Twin Study Network on Schizophrenia (EUTwinsS) were assessed on two domains that are consistently found to be particularly compromised in schizophrenia. Specifically, Intellectual Quotient Score (IQ) and the Letter-Number Sequencing Test (LNS), a measure of working memory, were measured in all twins. Latent variable components were explored through structural equation modeling, and common genetic underpinnings were examined using bivariate analyses. Results showed that the phenotypic correlation between IQ and working memory was almost entirely attributed to shared genetic variance (95.5%). We discuss the potential use of a combined measure of IQ and working memory to improve the power of molecular studies in detecting the genetic mechanisms underlying schizophrenia. PMID:23650229

Goldberg, Ximena; Alemany, Silvia; Rosa, Araceli; Picchioni, Marco; Nenadic, Igor; Owens, Sheena F; Rijsdijk, Fruhling; Rebollo, Irene; Sauer, Heinrich; Murray, Robin M; Fañanás, Lourdes; Toulopoulou, Timothea

2013-05-03

427

The Relationship Between Birth Weight and Hypodontia in Twins.  

National Technical Information Service (NTIS)

The relationship between birth weight and congenitally missing teeth (hypodontia) was investigated in 262 twins from the naval recruit population. Hypodontia occurred more frequently in twins than in the general population. The frequency of 'prematurity' ...

H. J. Keene

1969-01-01

428

Synergistic convergence and split pons in horizontal gaze palsy and progressive scoliosis in two sisters.  

PubMed

Synergistic convergence is an ocular motor anomaly where on attempted abduction or on attempted horizontal gaze, both the eyes converge. It has been related to peripheral causes such as congenital fibrosis of extraocular muscles (CFEOM), congenital cranial dysinnervation syndrome, ocular misinnervation or rarely central causes like horizontal gaze palsy with progressive scoliosis, brain stem dysplasia. We hereby report the occurrence of synergistic convergence in two sisters. Both of them also had kyphoscoliosis. Magnetic resonance imaging (MRI) brain and spine in both the patients showed signs of brain stem dysplasia (split pons sign) differing in degree (younger sister had more marked changes). PMID:21350292

Jain, Nitin R; Jethani, Jitendra; Narendran, Kalpana; Kanth, L

429

Synergistic convergence and split pons in horizontal gaze palsy and progressive scoliosis in two sisters  

PubMed Central

Synergistic convergence is an ocular motor anomaly where on attempted abduction or on attempted horizontal gaze, both the eyes converge. It has been related to peripheral causes such as congenital fibrosis of extraocular muscles (CFEOM), congenital cranial dysinnervation syndrome, ocular misinnervation or rarely central causes like horizontal gaze palsy with progressive scoliosis, brain stem dysplasia. We hereby report the occurrence of synergistic convergence in two sisters. Both of them also had kyphoscoliosis. Magnetic resonance imaging (MRI) brain and spine in both the patients showed signs of brain stem dysplasia (split pons sign) differing in degree (younger sister had more marked changes).

Jain, Nitin R; Jethani, Jitendra; Narendran, Kalpana; Kanth, L

2011-01-01

430

The Yeast Med1 Mutant Undergoes Both Meiotic Homolog Nondisjunction and Precocious Separation of Sister Chromatids  

PubMed Central

A mutant at the yeast MED1 locus was isolated in a screen for sporulation-proficient, meiotic-lethal mutants. Synaptonemal complex formation in the med1 mutant is apparently normal and med1 strains undergo meiotic crossing over at approximately 50% of the wild-type level. The med1 mutant undergoes homolog nondisjunction at meiosis I, presumably as a consequence of the decrease in crossing over. In addition, the mutant undergoes precocious separation of sister chromatids, resulting in chromosome missegregation at both meiotic divisions. We suggest that the med1 mutation perturbs chromosome structure, leading to a reduction in recombination and a defect in sister chromatid cohesion.

Rockmill, B.; Roeder, G. S.

1994-01-01

431

Brain Neuroplasticity in Healthy, Hyperactive and Psychotic Children: Insights from Neuroimaging  

Microsoft Academic Search

Noninvasive brain imaging permits longitudinal studies of anatomic brain development in healthy and psychiatrically ill children. The time course for gray matter maturation varies by region and parallels earlier histological studies, indicating dynamic patterns of overproduction and regression. Developmental trajectories vary in relation to gender, intelligence, and overall functioning. Twin studies show high heritability for brain volumes, which varies with

Judith L Rapoport; Nitin Gogtay

2008-01-01

432

Low twinning rate and seasonal effects on twinning in a fertile population, the Hutterites  

NASA Astrophysics Data System (ADS)

This paper analyzes from the mid 18th century to 1987 the birth records of the “Dariusleut,” one of the three subgroups of the Hutterite population. The aim of this study is to describe several aspects of the twinning rate in a fertile population. The overall rate of twinning was 0.90%:103 twins among all 11492 maternities. The rate peaked at the 7th birth order and at the maternal age of 40 years and over. Until the mid 19th century when the Hutterites lived in Russia, the twinning rate was higher (1.5%), and it decreased during the migration period in the second half of the 19th century (0.7%). After the group had settled in the USA and Canada, the population maintained a twinning rate of 1.0% until 1965. After 1965 the rate decreased to 0.7%, partly due to a decline in fertility among women aged 30 years and over. There was a significant seasonal variation: the twinning rate decreased to 0.5% in May July compared to 1.2% for the other three seasons during the years up to 1965 ( P<0.01), while more recent mothers did not show such a seasonal variation. The incidence of twin births in this population seems to have been influenced by environmental factors, which would change their effect seasonally and secularly.

Nonaka, K.; Miura, T.; Peter, K.

1993-09-01

433

Genetic control of ethanol action on the central nervous system. An EEG study in twins.  

PubMed

The purpose of the investigation is to claify the genetic contribution to the interindividual variability of ethanol action on the central nervous system. The 52 adult male healthy twin pairs (26 MZ, 26 DZ) got 1.2 ml/kg ethanol p.o. under standardized conditions; furthermore, 13 non-twin subjects were repeatedly subjected to the same procedure in order to test the intraindividual variability. The EEG was recorded before and 60, 120, 180, and 240 min after alcohol intake. The EEGs were off-line analyzed by means of a computer program for time domain analysis. As was already known, on the average alcohol led to a better synchronisation of the EEG, i.e., the number of beta-waves decreased whereas the number of alpha- and theta-waves increased. The extent of the alcohol effect on the EEG varied enormously between individuals; however, the EEGs of MZ twins proved to react indentically to alcohol loading, whereas the EEGs of DZ twins became mor dissimilar during the course of the experiment. The low-voltage EEG presumably is resistant to alchohol; furthermore, it is supposed that there exists a special beta-prone EEG-type which is also genetic in origin. The identical EEG reaction of MZ twins to alcohol loading could not be attributed to more similar blood alcohol concentrations. It is hypothesized that the differences in the extent of the alcohol effect on the EEG between individuals might reflect differences in the sensitivity of the ascending reticular activating system. In the literature it has frequently been reported that alcoholics have preferentially brain wave patterns which are poorly synchronized. These findings are discussed in the light of the present results. PMID:557449

Propping, P

1977-03-14

434

Conjoined twins detected in the first trimester: a review.  

PubMed

Conjoined twinning occurs in 1 in 100 sets of monozygotic twins, 1 in 50,000 gestations or 1 in 250,000 live births. With the advent of ultrasound technology, prenatal diagnosis of conjoined twins is possible. This article provides a comprehensive review of conjoined twins detected in the first trimester including fetal gender, maternal age, parity, types of fusion, related ultrasound abnormalities, perinatal outcome and association with assisted reproduction. PMID:22212312

Chen, Chih-Ping; Hsu, Chin-Yuan; Su, Jun-Wei; Cindy Chen, Hsiao-En; Hwa-Ruey Hsieh, Alan; Hwa-Jiun Hsieh, Alex; Wang, Wayseen

2011-12-01

435

Combined vaginal-cesarean delivery of twin pregnancies  

Microsoft Academic Search

OBJECTIVE:To estimate the incidence and factors associated with combined vaginal-cesarean delivery in twin pregnancies.METHODS:We studied all twin births weighing 500 g or more during a 20-year period (1980–1999) at a tertiary care center. Major anomalies, monoamniotic and conjoined twins, and antepartum fetal deaths were excluded.RESULTS:During this 20-year period, 105,987 women delivered, of whom 1565 (1.5%) had twins. Of these, 1151

Vidia L Persad; Thomas F Baskett; Colleen M O’Connell; Heather M Scott

2001-01-01

436

Genetic influences on osteoarthritis in women: a twin study  

Microsoft Academic Search

AbstractObjectives: To assess the relative contribution of genetic and environmental factors to common forms of osteoarthritis of the hands and knees.Design: Classic twin study with unselected twins who were screened radiologically for osteoarthritis.Subjects: 130 identical and 120 non-identical female twins aged 48-70 recruited from a London based twin register and through a national media campaign.Main outcome measures: Similarity in identical

Tim D Spector; Flavia Cicuttini; Juliet Baker; John Loughlin; Deborah Hart

1996-01-01

437

Prenatal x-ray exposure and childhood cancer in twins  

Microsoft Academic Search

A case-control study was conducted to investigate the relation between prenatal exposure to x-rays and childhood cancer, including leukemia, in over 32,000 twins born in Connecticut from 1930 to 1969. Twins as opposed to single births were chosen for study to reduce the likelihood of medical selection bias, since twins were often exposed to x-rays to diagnose the twin pregnancy

Elizabeth B. Harvey; John D. Boice; Merton Honeyman; John T. Flannery

1985-01-01

438

Twinning and mechanical behavior of titanium aluminides and other intermetallics  

Microsoft Academic Search

Based on the recent studies of deformation twinning in ordered intermetallics, the general background on slip-twinning-microcracking relationships is established. Specific roles of deformation twinning in the generalized plasticity of polycrystals and the crack-tip microplasticity are discussed in terms of the local strain compatibility by invoking both ‘tension’ and ‘compression’ twins. Special examples are given for ?-TiAl, other L10 alloys, and

M. H. Yoo

1998-01-01

439

Complicated monochorionic twin pregnancies: Experience with bipolar cord coagulation  

Microsoft Academic Search

Objective: The purpose of the study was to evaluate our experience with ultrasound-guided bipolar diathermy forceps for cord occlusion in complicated monochorionic twin pregnancies. Study Design: Seventeen consecutive cases were included: 9 cases were twin-to-twin transfusion syndrome; 2 cases were twin reversed arterial perfusion syndrome, and 6 cases were discordant for fetal abnormality. Bipolar diathermy was performed under local anesthetic

Umberto Nicolini; Andres Poblete; Chiara Boschetto; Francesca Bonati; Alistair Roberts

2001-01-01

440

Twin heart with a fused atria and separate ventricles in conjoined twins  

PubMed Central

One of the most interesting congenital malformations is that of conjoined twins. We report echocardiographic features of twin heart in dicephalus, tribrachius, dispinous, thoracoomphalopagus twin. It showed two hearts fused at atrial level. Right-sided heart had single atrial chamber with a single ventricle. A single great vessel, aorta, originated from it. Left-sided heart was well developed with two atria and two ventricles. There was a small mid muscular ventricular septal defect and a small patent ductus arteriosus. Great arteries had normal origins.

Ambar, Sameer Suresh; Halkati, Prabhu C; Patted, Suresh V; Yavagal, ST

2010-01-01

441

Analysis of 104 twin pregnancies conceived with assisted reproductive technologies and 193 spontaneously conceived twin pregnancies  

Microsoft Academic Search

Objective: To evaluate pregnancy outcome of assisted reproductive technology (ART)-conceived twin pregnancies.Design: Retrospective study.Setting: A tertiary obstetric care center.Patient(s): All twin pregnancies delivered ?24 weeks of gestation from January 1, 1996, to December 31, 1997.Intervention(s): Maternal and neonatal record review.Main Outcome Measure(s): Pregnancy and perinatal outcome.Result(s): The study group comprised 104 ART-conceived twin pregnancies, and 193 non-ART-conceived pregnancies served as

Yair Daniel; Yifat Ochshorn; Gideon Fait; Eli Geva; Amiram Bar-Am; Joseph B Lessing

2000-01-01

442

Genetic influences on premature parturition in an Australian twin sample  

Microsoft Academic Search

We investigated possible genetic influences on women's liability to preterm birth, using data from a large sample of Australian female twin pairs. In a 1988-90 questionnaire survey, both members of 905 parous twin pairs (579 monozygotic and 326 dizygotic) reported on whether deliveries had been more than two weeks preterm. Tetrachoric twin pair correlations for first birth were rMZ =

Susan A Treloar; George A Macones; Laura E Mitchell; Nicholas G Martin

2000-01-01

443

Twin studies on obsessive-compulsive disorder: a review  

Microsoft Academic Search

Genetic factors have historically been thought of as important in the development of obsessive-compulsive disorder (OCD). For the estimation of the relative importance of genetic and environmental factors, twin studies are an obvious approach. Twin studies of OCD have a long history, starting in 1929. In this review, over 70 years of twin research of OCD is presented, using four

Grootheest van D. S; Daniëlle C. Cath; Aartjan T. Beekman; Dorret I. Boomsma

2005-01-01

444

Dicephalus dipus dibrachius: An unusual case of conjoined twins  

Microsoft Academic Search

Conjoined twinning is a rare anomaly, occurring in one of every 50,000 births. Dicephalus dipus dibrachius is an extremely rare form of conjoined twinning in which the infant has two arms, two legs, one trunk, but two heads. These infants are often stillborn or die shortly after birth. The authors describe a case of dicephalus twinning with 11-day survival. A

Jonathan I. Groner; Douglas W. Teske; Steven Teich

1996-01-01

445

Regression models for twin studies: a critical review  

Microsoft Academic Search

Twin studies have long been recognized for their value in learning about the aetiology of disease and specifically for their potential for separating genetic effects from environmental effects. The recent upsurge of interest in life-course epidemiology and the study of developmental influences on later health has provided a new impetus to study twins as a source of unique insights. Twins

John B Carlin; Lyle C Gurrin; Jonathan AC Sterne; Ruth Morley; Terry Dwyer

2005-01-01

446

Child Mortality Among Twins in Less Developed Countries  

Microsoft Academic Search

Although twins constitute only about 2.4 per cent of total births in less developed countries, they account for about 12 per cent of neonatal deaths and about nine per cent of infant deaths. Twin mortality in less developed countries has almost never been analysed systematically. We examine survival among twins as contrasted with that among singleton births by using 2692

Guang Guo; Laurence M. Grummer-Strawn

1993-01-01

447

A Multivariate Twin Study of Early Literacy in Japanese "Kana"  

ERIC Educational Resources Information Center

|This first Japanese twin study of early literacy development investigated the extent to which genetic and environmental factors influence individual differences in prereading skills in 238 pairs of twins at 42 months of age. Twin pairs were individually tested on measures of phonological awareness, "kana" letter name/sound knowledge, receptive…

Fujisawa, Keiko K.; Wadsworth, Sally J.; Kakihana, Shinichiro; Olson, Richard K.; DeFries, John C.; Byrne, Brian; Ando, Juko

2013-01-01

448

Olfactory Functioning and Cognitive Abilities: A Twin Study  

Microsoft Academic Search

A Swedish version of the National Geographic Smell Survey (Wysocki & Gilbert, 1989) was completed by 227 twin pairs from the Swedish Adoption\\/Twin Study of Aging. Twins ranged in age from 45 to 89 years. Quantita- tive genetic analysis of four measures of olfactory functioning indicated moderate heritability for odor identifica- tion and perceived intensity and nonsignificant heritability for odor

Deborah Finkel; Nancy L. Pedersen; Maria Larsson

2001-01-01

449

A Factor Analysis of Creativity in Fraternal and Identical Twins  

Microsoft Academic Search

The relationship between intelligence and creativity and their factorial structure have been extensively discussed, with little empirical evidence and less agreement as to the meaning. A study of 117 pairs of like sexed fraternal and identical twins was undertaken, with each twin participating in an extensive battery of creativity tests. A factor analysis indicated three factors for the fraternal twins

George Domino; John Walsh; Marvin Reznikoff; Merton Honeyman

1976-01-01

450

The Kinetics of Twinning in Zinc and Tin Crystals  

Microsoft Academic Search

By using a high speed rotating mirror camera combined with a microscope, the rapid initial lengthening of twins and their subsequent broadening have been studied. In zinc, twins of up to 1\\\\cdot9 mm appeared in crystal surfaces within 1 mus and subsequently the tips of such twins were observed to move at up to 780 m\\/s. It is pointed out

J. H. Brunton; M. P. W. Wilson

1969-01-01

451

Effects of Twinning on Lactation and Days Open in Holsteins  

Microsoft Academic Search

Effects of twinning on lactation and days open in Holsteins were studied from calving records compiled by member surveys of Eastern Artificial Insemination Cooperative. Records of cows with 305-day mature-equivalent records from the Northeast Dairy Records Processing Laboratory were grouped according to whether the twin calving was associated with dystocia. Records of each cow that had a twin calving were

C. A. Chapin; L. D. Van Vleck

1980-01-01

452

Perinatal Outcomes of Twin Pregnancies Discordant for Major Fetal Anomalies  

Microsoft Academic Search

Objective: The aim of this study was to determine perinatal outcomes of twin pregnancies discordant for a major fetal anomaly and to compare with twins without anomaly. Methods: All twin pregnancies admitted or referred to the maternal-fetal unit were prospectively entered into a computer database. Chorionicity, fetal anomaly, mean gestational age at delivery, birth weight and perinatal survival rate were

Ahmet Gul; Altan Cebeci; Halil Aslan; Ibrahim Polat; Ilker Sozen; Yavuz Ceylan

2005-01-01

453

A Better Way to Use Twins for Developmental Research  

Microsoft Academic Search

By now most psychological researchers are accustomed to twin studies and know the basics: You measure a trait of interest in identical (MZ, for monozygotic; sharing all their genes) and fraternal (DZ, for dizygotic; sharing a random half their genes, like ordinary siblings) twins, compute the MZ and DZ twin correlations, and compare them. With a few assumptions and a

Eric Turkheimer

454

"Hugging sisters": thoracoomphalopagus with anencephaly confirmed by three-dimensional ultrasonography at 9 weeks of gestation.  

PubMed

We describe a rare conjoined twinning at 9 weeks of gestation. We compared the results of two- and three-dimensional sonography with autopsy findings after the termination of pregnancy. These results showed a thoracoomphalopagus with a shared heart and visceral organs. Three-dimensional sonography showed anencephaly in one of the embryos. Early and accurate prenatal diagnosis of this type of conjoined twins using three-dimensional sonography is critical for both parental counseling and minimizing maternal morbidity. PMID:21547928

Shim, Jae-Yoon; Joo, Da-Hye; Won, Hye-Sung; Lee, Pil Ryang; Kim, Ahm

2010-11-29

455

Identical unerupted maxillary incisors in monozygotic twins.  

PubMed

Mesiodens is the most common type of supernumerary tooth found in the premaxilla. It might be discovered by the orthodontist by chance on a radiograph or as the cause of an unerupted maxillary central incisor. The genetic transmission of supernumerary and impacted teeth is poorly understood. The occurrence of identical unerupted maxillary central incisors and mesiodentes in monozygotic twins suggests that genetic factors might influence the etiology of this problem. In this case report, we discuss the treatment of unerupted maxillary permanent incisors caused by mesiodentes in monozygotic twins. PMID:20889057

Babacan, Hasan; Öztürk, F?rat; Polat, Hidayet Burak

2010-10-01

456

Twin inequality for fully contextual quantum correlations  

NASA Astrophysics Data System (ADS)

Quantum mechanics exhibits a very peculiar form of contextuality. Identifying and connecting the simplest scenarios in which more general theories can or cannot be more contextual than quantum mechanics is a fundamental step in the quest for the principle that singles out quantum contextuality. The former scenario corresponds to the Klyachko-Can-Binicio?lu-Shumovsky (KCBS) inequality. Here we show that there is a simple tight inequality, twin to the KCBS, for which quantum contextuality cannot be outperformed. In a sense, this twin inequality is the simplest tool for recognizing fully contextual quantum correlations.

Cabello, Adán

2013-01-01

457

Faceting of twin tips in polysilicon films  

NASA Astrophysics Data System (ADS)

The faceting of tips of twin plates in the interior of grains under annealing in phosphorus-doped polysilicon films, produced by low-pressure chemical vapor deposition, has been investigated by transmission electron microscopy. It has been shown that the facet types and number of facets depend on the annealing temperature. The stability diagram for the different facet types has been constructed. Three kinds of faceting transitions that take place on the twin tips have been studied. The transformation of curved grain boundary into a grain boundary facet with increasing temperature has been observed for the first time.

Nakhodkin, N. G.; Kulish, N. P.; Rodionova, T. V.

2013-10-01

458

Epicyclic Twin-Helix Ionization Cooling Simulations  

SciTech Connect

Parametric-resonance Ionization Cooling (PIC) is proposed as the final 6D cooling stage of a highluminosity muon collider. For the implementation of PIC, we earlier developed an epicyclic twin-helix channel with correlated behavior of the horizontal and vertical betatron motions and dispersion. We now insert absorber plates with short energy-recovering units located next to them at the appropriate locations in the twin-helix channel. We first demonstrate conventional ionization cooling in such a system with the optics uncorrelated. We then adjust the correlated optics state and induce a parametric resonance to study ionization cooling under the resonant condition.

Vasiliy Morozov, Yaroslav Derbenev, A. Afanaciev, R.P. Johnson

2011-04-01

459

Achondroplasia in female twins: surgical indications.  

PubMed

Although in literature achondroplasia has been described profusely, reports on achondroplastic twins are limited. We present two cases of monozygotic female twins with achondroplasia, who underwent limb-lengthening surgical procedure with external fixation in the following five steps: tibia, femur, tibia; femur, homer. Both the cases presented a good limb length and an optimal correction of associated deformities after the treatment, fulfilling the indications. Surgical indications were mostly led by the axial deviations of the lower limbs, and the timing of the limb-lengthening procedures has been the same in both couples showing the importance of this aspect. PMID:21088624

Albisetti, Walter; Pedretti, Leopoldo; De Bartolomeo, Omar; Verdoni, Fabio; Memeo, Antonio

2011-03-01

460

Twinning in Cs 2YbNb 6Br 18and the Atomic Structure of the Twin Interface  

Microsoft Academic Search

In the search for defects in crystals of the cluster compound Cs2YbNb6Br18, polysynthetic microtwinning was observed by electron diffraction and high-resolution electron microscopy (HREM), and the complete twin law could be determined. The twinning element is a twofold screw axis along [001], and the perfectly smooth twin interface is parallel to (110) of the rhombohedral unit cell. From the twin

R. Ramlau; V. Duppel; A. Simon; S. Cordier; C. Perrin; M. Sergent

1998-01-01

461

[Comparative informative value of chromosome aberrations and sister chromatid exchanges in the evaluation of metals in the environment].  

PubMed

Simultaneous recording of the frequency of chromosomal aberrations and sister chromatid exchanges supplements data on the nature of genetic disorders in the sanitary and toxicological assessment of metals polluting the environment. A obvious threshold of genetic effects of metals was not revealed in the context of chromosomal aberrations and sister chromatid exchanges. Methods for detecting the genotoxicity of metals await further search. PMID:9244777

Nadeenko, V G; Gol'dina, I R; D'iachenko, O Z; Pestova, L V

462

GFP tagging of budding yeast chromosomes reveals that protein–protein interactions can mediate sister chromatid cohesion  

Microsoft Academic Search

Background Precise control of sister chromatid separation is essential for the accurate transmission of genetic information. Sister chromatids must remain linked to each other from the time of DNA replication until the onset of chromosome segregation, when the linkage must be promptly dissolved. Recent studies suggest that the machinery that is responsible for the destruction of mitotic cyclins also degrades

Aaron F. Straight; Andrew S. Belmont; Carmen C. Robinett; Andrew W. Murray

1996-01-01

463

The Cohesion Protein MEI-S332 Localizes to Condensed Meiotic and Mitotic Centromeres until Sister Chromatids Separate  

Microsoft Academic Search

The Drosophila MEI-S332 protein has been shown to be required for the maintenance of sister- chromatid cohesion in male and female meiosis. The protein localizes to the centromeres during male meio- sis when the sister chromatids are attached, and it is no longer detectable after they separate. Drosophila mela- nogaster male meiosis is atypical in several respects, making it important

Daniel P. Moore; Andrea W. Page; Tracy Tzu-Ling Tang; Anne W. Kerrebrock; Terry L. Orr-Weaver

1998-01-01

464

Acute hemorrhage in monochorionic twins with ruptured velamentous vessels: anemic twin resuscitated by its co-twin through placental vascular anastomoses?  

PubMed

Monochorionic (MC) twin pregnancies are at increased risk of several complications including acute or chronic twin-twin transfusion syndrome (TTTS) and twin anemia-polycythemia sequence (TAPS). Both TTTS and TAPS result from inter-twin fetofetal transfusion through the placental vascular anastomoses. In addition, MC twin pregnancies are at increased risk of having a velamentous cord insertion, which has been linked with poor perinatal outcome due to risk of rupture of the velamentous vessels. In sporadic cases, these vascular connections may have a positive effect instead of a deleterious effect. We present a case of acute fetal distress in a MC twin pregnancy caused by acute hemorrhage following rupture of velamentous vessels. An emergency cesarean section delivery was performed at 29+2 weeks' gestation. One infant was severely anemic at birth and required immediate treatment with volume expansion and blood transfusion. Acute fetal blood loss through the ruptured vessels led to an acute fetofetal transfusion from the co-twin through the placental vascular anastomoses. Delayed intervention could have resulted in severe hypovolemic shock and acute anemia in both fetuses. Instead, in the current case, placental vascular anastomoses had a transient protective role and allowed transfusion of blood from one co-twin into the circulation of the anemic twin. PMID:23295623

Gillissen, A; Sueters, M; van Lith, J M; Walther, F J; Lopriore, E

2013-01-03

465

A core gut microbiome in obese and lean twins  

PubMed Central

The human distal gut harbors a vast ensemble of microbes (the microbiota) that provide us with important metabolic capabilities, including the ability to extract energy from otherwise indigestible dietary polysaccharides1–6. Studies of a small number of unrelated, healthy adults have revealed substantial diversity in their gut communities, as measured by sequencing 16S rRNA genes6–8, yet how this diversity relates to function and to the rest of the genes in the collective genomes of the microbiota (the gut microbiome) remains obscure. Studies of lean and obese mice suggest that the gut microbiota affects energy balance by influencing the efficiency of calorie harvest from the diet, and how this harvested energy is utilized and stored3–5. To address the question of how host genotype, environmental exposures, and host adiposity influence the gut microbiome, we have characterized the fecal microbial communities of adult female monozygotic and dizygotic twin pairs concordant for leanness or obesity, and their mothers. Analysis of 154 individuals yielded 9,920 near full-length and 1,937,461 partial bacterial 16S rRNA sequences, plus 2.14 gigabases from their microbiomes. The results reveal that the human gut microbiome is shared among family members, but that each person’s gut microbial community varies in the specific bacterial lineages present, with a comparable degree of co-variation between adult monozygotic and dizygotic twin pairs. However, there was a wide array of shared microbial genes among sampled individuals, comprising an extensive, identifiable ‘core microbiome’ at the gene, rather than at the organismal lineage level. Obesity is associated with phylum-level changes in the microbiota, reduced bacterial diversity, and altered representation of bacterial genes and metabolic pathways. These results demonstrate that a diversity of organismal assemblages can nonetheless yield a core microbiome at a functional level, and that deviations from this core are associated with different physiologic states (obese versus lean).

Turnbaugh, Peter J.; Hamady, Micah; Yatsunenko, Tanya; Cantarel, Brandi L.; Duncan, Alexis; Ley, Ruth E.; Sogin, Mitchell L.; Jones, William J.; Roe, Bruce A.; Affourtit, Jason P.; Egholm, Michael; Henrissat, Bernard; Heath, Andrew C.; Knight, Rob; Gordon, Jeffrey I.

2008-01-01

466

Comparing blood pressure of twins and their singleton siblings: being a twin does not affect adult blood pressure  

Microsoft Academic Search

he hypothesis was tested that monozygotic (MZ) and dizy- gotic (DZ) twins, with their lower average birth weight, have higher adult blood pressure than their singleton brothers or sis- ters. From the Netherlands Twin Registry, 261 twin families were recruited from a young adult and an older adult cohort with mean ages of 26.2 and 50.4 respectively. These families yielded

Geus de E. J. C; Danielle Posthuma; Richard G. Ijzerman; Dorret I. Boomsma

2001-01-01

467

Perinatal Outcome of Conservative Management versus Fetal Intervention for Twin Reversed Arterial Perfusion Sequence with a Small Acardiac Twin  

Microsoft Academic Search

Objective: To examine the outcomes of patients with twin reversed arterial perfusion (TRAP) sequence in which the acardiac twin was ?50% the weight of the pump twin. Methods: This was a retrospective study conducted with institutional review board approval. The records of all patients referred to UCSF for suspected diagnosis of TRAP between 1994 and 2009 were reviewed (n =

Eric Jelin; Shinjiro Hirose; Larry Rand; Patrick Curran; Vickie Feldstein; Salvador Guevara-Gallardo; Angie Jelin; Kelly Gonzales; Ruth Goldstein; Hanmin Lee

2010-01-01

468

EAS Temperaments During the Last Half of the Life Span: Twins Reared Apart and Twins Reared Together  

Microsoft Academic Search

In this first behavioral genetic study of personality in the last half of the life span, results are reported using the powerful adoption\\/twin design that compares identical and fraternal twins reared apart and identical and fraternal twins reared together. Traits studied were the EAS temperaments (emotionality, activity level, and sociability), traits that show substantial genetic influence in childhood. It was

Robert Plomin; Nancy L. Pedersen; G. E. McClearn; John R. Nesselroade; C. S. Bergeman

1988-01-01

469

Selection Bias in Samples of Older Twins?A Comparison between Octogenarian Twins and Singletons in Sweden  

Microsoft Academic Search

Twin studies are a powerful approach for estimating genetic and environmental influences in later life, but the usual requirement that both twins are alive may introduce a selection bias in gerontological studies relative to representative samples of nontwins. In the present study, samples of older twins and nontwins in Sweden were compared across the domains of vitality, well-being, physical and

Sandra F. Simmons; Boo Johansson; Steven H. Zarit; Birgit Ljungquist; Robert Plomin; Gerald E. Mcclearn

1997-01-01

470

Healthy Eating with Diabetes Video  

MedlinePLUS Videos and Cool Tools

... Healthy Eating with Diabetes Video Healthy Eating with Diabetes Video Making changes in the way you eat ... help you manage your weight. Healthy Eating with Diabetes Subtitle Healthy Eating with Diabetes Transcript Healthy Eating ...

471

When the Sisters Said Farewell: The Transition of Leadership in Catholic Elementary Schools  

ERIC Educational Resources Information Center

|"When the Sisters Said Farewell" tells an important story of the contributions of Catholic elementary schools to the United States by chronicling the experiences and insights of religious women (nuns) who were the last members of their communities to serve in parish elementary schools, and of those lay men and women who were the first to serve in…

Caruso, Michael P., S.J.

2012-01-01

472

High-functioning autism spectrum disorder and fragile X syndrome: report of two affected sisters  

PubMed Central

Background Fragile X syndrome (FXS) is the most common inherited cause of intellectual disability (ID), as well as the most frequent monogenic cause of autism spectrum disorder (ASD). Men with FXS exhibit ID, often associated with autistics features, whereas women heterozygous for the full mutation are typically less severely affected; about half have a normal or borderline intelligence quotient (IQ). Previous findings have shown a strong association between ID and ASD in both men and women with FXS. We describe here the case of two sisters with ASD and FXS but without ID. One of the sisters presented with high-functioning autism, the other one with pervasive developmental disorder not otherwise specified and low normal IQ. Methods The methylation status of the mutated FMR1 alleles was examined by Southern blot and methylation-sensitive polymerase chain reaction. The X-chromosome inactivation was determined by analyzing the methylation status of the androgen receptor at Xq12. Results Both sisters carried a full mutation in the FMR1 gene, with complete methylation and random X chromosome inactivation. We present the phenotype of the two sisters and other family members. Conclusions These findings suggest that autistic behaviors and cognitive impairment can manifest as independent traits in FXS. Mutations in FMR1, known to cause syndromic autism, may also contribute to the etiology of high-functioning, non-syndromic ASD, particularly in women. Thus, screening for FXS in patients with ASD should not be limited to those with comorbid ID.

2012-01-01

473

Making a Difference in Schools: The Big Brothers Big Sisters School-Based Mentoring Impact Study  

ERIC Educational Resources Information Center

School-based mentoring is one of the fastest growing forms of mentoring in the US today; yet, few studies have rigorously examined its impacts. This landmark random assignment impact study of Big Brothers Big Sisters School-Based Mentoring is the first national study of this program model. It involves 10 agencies, 71 schools and 1,139 9- to…

Herrera, Carla; Grossman, Jean Baldwin; Kauh, Tina J.; Feldman, Amy F.; McMaken, Jennifer

2007-01-01

474

Brothers and Sisters: A Source of Support for Children in School?  

ERIC Educational Resources Information Center

Whilst UK schools move towards U.S "big brother" style mentoring systems for children, are actual brothers and sisters becoming an invisible source of support to deal with bullying in everyday life? This paper reports on research with children aged 7-13 about their experiences and understandings of their relationships with their brothers and…

Hadfield, Lucy; Edwards, Rosalind; Mauthner, Melanie

2006-01-01

475

Making a Difference. An Impact Study of Big Brothers/Big Sisters.  

ERIC Educational Resources Information Center

This report provides reliable evidence that mentoring programs can positively affect young people. The evidence is derived from research conducted at local affiliates of Big Brothers/Big Sisters of America (BB/BSA), the oldest, best-known, and arguably most sophisticated of the country's mentoring programs. Public/Private Ventures, Inc. conducted…

Tierney, Joseph P.; And Others

476

Mentoring in Schools: An Impact Study of Big Brothers Big Sisters School-Based Mentoring  

ERIC Educational Resources Information Center

This random assignment impact study of Big Brothers Big Sisters School-Based Mentoring involved 1,139 9- to 16-year-old students in 10 cities nationwide. Youth were randomly assigned to either a treatment group (receiving mentoring) or a control group (receiving no mentoring) and were followed for 1.5 school years. At the end of the first school…

Herrera, Carla; Grossman, Jean Baldwin; Kauh, Tina J.; McMaken, Jennifer

2011-01-01

477

Big Brothers/Big Sisters: A Study of Volunteer Recruitment and Screening.  

ERIC Educational Resources Information Center

Since 1988, Public/Private Ventures of Philadelphia (Pennsylvania) has been conducting a series of studies of mentoring programs for at-risk youth. As part of this effort, the recruitment and screening procedures used by Big Brother/Big Sister (BB/BS) agencies were studied in eight cities. Recruitment for the high-profile BB/BS agencies is not as…

Roaf, Phoebe A.; And Others

478

Nutrient regulation in relation to diet breadth: a comparison of Heliothis sister species and a hybrid  

Microsoft Academic Search

We examined the nutritional correlates of diet breadth in insect herbivores by comparing patterns of diet selection, nutrient balancing, post-ingestive utilization and development in two sister species of caterpillar and a hybrid between them. One species, Heliothis virescens (HV) has a broad host range, feeding on plants in at least 14 families. The other, Heliothis subflexa (HS), is a specialist

Kwang Pum Lee; Spencer T. Behmer; Stephen J. Simpson

2006-01-01

479

Three Sisters: Lessons of Traditional Story Honored in Assessment and Accreditation  

ERIC Educational Resources Information Center

|The three sisters story is shared across many tribes. It explains the practice of planting corn, beans, and squash together. The corn stalks provide support for the bean vines; the beans provide nitrogen for the corn; and the squash prevents weed growth between the mounds. Such stories explain not only the science of agricultural methods in…

Chenault, Venida S.

2008-01-01

480

Persistence of DNA lesions and the cytological cancellation of sister chromatid exchanges  

Microsoft Academic Search

The ability of UV light, mitomycin C and ionizing radiation to induce the formation of sister chromatid exchanges (SCEs) at the same locus in successive cell generations was investigated in human lymphocytes. Cells were exposed to the DNA damaging agents after they had completed their first round of DNA replication, and SCEs were examined at the third division in chromosomes

J. B. Schvartzman; V. J. Goyanes; A. Campos; A. M. Lage; C. Veiras; M. C. Silva; S. Ramos

1985-01-01