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Sample records for healthy twin sisters

  1. Mercury poisoning in two 13-year-old twin sisters.

    PubMed

    Khodashenas, Ezzat; Aelami, Mohammadhassan; Balali-Mood, Mahdi

    2015-03-01

    Mercury (Hg) is a toxic agent that evaporates in room temperature and its inhalation may cause poisoning. Due to the nonspecific symptoms, diagnosis is difficult in special circumstances with no initial history of Hg exposure. We report two such cases of Hg poisoning. The patients were two sisters, presenting with pain in extremities, itchy rashes, sweating, salivation, weakness, and mood changes. They have used a compound that contains mercury, for treatment of pedicullosis three months before admission. This compound was purchased from a herbal shop and was applied locally on the scalps for 2 days. Their urinary mercury concentrations were 50 and 70 mg/L. They were successfully treated by D-penicillamine and gabapentin. In a patient with any kind of bone and joint pain, skin rash erythema and peripheral neuropathy, mercury poisoning should be considered as a differential diagnosis. PMID:26109979

  2. JAGGED1 gene variations in Chinese twin sisters with Alagille syndrome

    PubMed Central

    Xie, Xinbao; Lu, Yi; Wang, Xiaohong; Wu, Bingbing; Yu, Hui

    2015-01-01

    Variations in the JAGGED1 gene have been found to cause Alagille syndrome. Nevertheless, no particular hotspots in the gene have been found; any part of the entire coding regions for JAGGED1 may be involved. Twin sisters with jaundice visited our hospital and were diagnosed with Alagille syndrome. The gene variations in their JAGGED1 coding sequences were evaluated by complementary DNA sequencing. The 12-month-old twin sisters have broad foreheads, deep-set eyes, pointed chins, and triangular faces with jaundice. Clinical testing showed the presence of posterior embryotoxon, butterfly vertebrae, and atrial septal defect. Biochemical indexes showed cholestasis and liver damage. Three conserved variations were identified within exons 22 (c.2612C>G), 24 (c.2957T>A), and 26 (c.3417T>C) in the JAGGED1 coding sequence. The predicted consequences for c.2612C>G, c.2957T>A, and c.3417T>C were p.Pro871Arg, p.Leu986*, and p.Tyr1139=, respectively. The T to A change in the JAGGED1 coding sequence at 2957 will generate a stop codon and might lead to deletion of amino acid 233 at the C terminal of the JAGGED1 protein. Our data suggest that gene variations of c.2612C>G, c.2957T>A, and c.3417T>C, especially c.2957T>A, might have contributed to the pathogenesis of Alagille syndrome in these Chinese twin sisters and provided new gene evidences for Alagille syndrome. PMID:26339425

  3. FLOWERING LOCUS T has higher protein mobility than TWIN SISTER OF FT

    PubMed Central

    Jin, Suhyun; Jung, Hye Seung; Chung, Kyung Sook; Lee, Jeong Hwan; Ahn, Ji Hoon

    2015-01-01

    In plants, successful reproduction requires the proper timing of flowering under changing environmental conditions. Arabidopsis FLOWERING LOCUS T (FT), which encodes a proposed phloem-mobile florigen, has a close homologue, TWIN SISTER OF FT (TSF). During the vegetative phase, TSF shows high levels of expression in the hypocotyl before FT induction, but the tsf mutation does not have an apparent flowering-time phenotype on its own under long-day conditions. This study compared the protein mobility of FT and TSF. With TSF-overexpressing plants as the rootstock, the flowering time of ft tsf scion plants was only slightly accelerated. Previous work has shown that FT is graft-transmissible; by contrast, this study did not detect movement of TSF from the roots into the shoot of the scion plants. This study used plants overexpressing FT/TSF chimeric proteins to map a region responsible for FT movement. A chimeric TSF with region II of FT (L28 to G98) expressed in the rootstock caused early flowering in ft tsf scion plants; movement of the chimeric protein from the rootstocks into the shoot apical region of the ft tsf scion plants was also detected. Misexpression of TSF in the leaf under the control of the FT promoter or grafting of 35S::TSF cotyledons accelerated flowering of ft-10 plants. FT was more stable than TSF. Taking these results together, we propose that protein mobility of FT is higher than that of TSF, possibly due to a protein domain that confers mobility and/or protein stability. PMID:26139827

  4. Testing of the "Healthy 'Little' Lives Project": A Training Program for Big Sister Mentors

    ERIC Educational Resources Information Center

    Kaufman, Michelle R.

    2010-01-01

    Big Brothers/Big Sisters is a national program aimed at providing mentors for disadvantaged children. This study tested whether Big Sister mentors could be trained to increase communication with their Little Sisters about sexual health issues. The study tested an intervention based on social cognitive theory in which a sexual health communication…

  5. UNIVERSITY OF MINNESOTA Twin Cities Campus MILK Study: Mothers and Infants LinKed for Healthy Growth

    E-print Network

    UNIVERSITY OF MINNESOTA Twin Cities Campus MILK Study: Mothers and Infants LinKed for Healthy Growth University of Minnesota Center for Neurobehavioral Development MILK Study 3-Month Visit Details;UNIVERSITY OF MINNESOTA Twin Cities Campus MILK Study: Mothers and Infants LinKed for Healthy Growth

  6. Similarities and differences in lipidomics profiles among healthy monozygotic twin pairs.

    PubMed

    Draisma, Harmen H M; Reijmers, Theo H; Bobeldijk-Pastorova, Ivana; Meulman, Jacqueline J; Estourgie-Van Burk, G Frederiek; Bartels, Meike; Ramaker, Raymond; van der Greef, Jan; Boomsma, Dorret I; Hankemeier, Thomas

    2008-03-01

    Differences in genetic background and/or environmental exposure among individuals are expected to give rise to differences in measurable characteristics, or phenotypes. Consequently, genetic resemblance and similarities in environment should manifest as similarities in phenotypes. The metabolome reflects many of the system properties, and is therefore an important part of the phenotype. Nevertheless, it has not yet been examined to what extent individuals sharing part of their genome and/or environment indeed have similar metabolomes. Here we present the results of hierarchical clustering of blood plasma lipid profile data obtained by liquid chromatography-mass spectrometry from 23 healthy, 18-year-old twin pairs, of which 21 pairs were monozygotic, and 8 of their siblings. For 13 monozygotic twin pairs, within-pair similarities in relative concentrations of the detected lipids were indeed larger than the similarities with any other study participant. We demonstrate such high coclustering to be unexpected on basis of chance. The similarities between dizygotic twins and between nontwin siblings, as well as between nonfamilial participants, were less pronounced. In a number of twin pairs, within-pair dissimilarity of lipid profiles positively correlated with increased blood plasma concentrations of C-reactive protein in one twin. In conclusion, this study demonstrates that in healthy individuals, the individual genetic background contributes to the blood plasma lipid profile. Furthermore, lipid profiling may prove useful in monitoring health status, for example, in the context of personalized medicine. PMID:18266560

  7. First Language Attrition in the Speech of Dutch-English Bilinguals: The Case of Monozygotic Twin Sisters

    ERIC Educational Resources Information Center

    Mayr, Robert; Price, Sacha; Mennen, Ineke

    2012-01-01

    Recent years have seen a proliferation of research on attrition in L1 speech (de Leeuw, Mennen & Scobbie, in press; de Leeuw, Schmid & Mennen, 2010; Dmitrieva, Jongman & Sereno, 2010; Mennen, 2004). Adding to this line of inquiry, the present study investigates the speech of a 62-year-old bilingual monozygotic twin who emigrated to an L2-speaking…

  8. UNIVERSITY OF MINNESOTA Twin Cities Campus MILK Study: Mothers and Infants LinKed for Healthy Growth

    E-print Network

    UNIVERSITY OF MINNESOTA Twin Cities Campus MILK Study: Mothers and Infants LinKed for Healthy Growth University of Minnesota Center for Neurobehavioral Development MILK Study Visit Details & Driving circumference of your baby's head, abdomen, arm and leg. #12;UNIVERSITY OF MINNESOTA Twin Cities Campus MILK

  9. UNIVERSITY OF MINNESOTA Twin Cities Campus MILK Study: Mothers and Infants LinKed for Healthy Growth

    E-print Network

    UNIVERSITY OF MINNESOTA Twin Cities Campus MILK Study: Mothers and Infants LinKed for Healthy Growth University of Minnesota Center for Neurobehavioral Development MILK Study Initial Visit Details form and weighing your baby #12;UNIVERSITY OF MINNESOTA Twin Cities Campus MILK Study: Mothers

  10. Modest genetic influence on bronchodilator response: a study in healthy twins

    PubMed Central

    Tarnoki, David Laszlo; Medda, Emanuela; Tarnoki, Adam Domonkos; Bikov, Andras; Lazar, Zsofia; Fagnani, Corrado; Stazi, Maria Antonietta; Karlinger, Kinga; Garami, Zsolt; Berczi, Viktor; Horvath, Ildiko

    2015-01-01

    Aim To determine the reasons for large standard deviation of bronchodilator response (BDR) and establish whether there is a potential heritable component in healthy subjects. Methods 67 monozygotic and 42 dizygotic adult twin pairs were assessed for bronchodilator response (%change in FEV1 after inhaling 400 µg salbutamol). Univariate quantitative genetic modeling was performed. Results Multiple regression modeling showed a significant association between BDR and sex and baseline FEV1 (P?twins was modest (0.332), but higher than in dizygotic twins (0.258). Age-, sex-, and baseline FEV1-adjusted genetic effect accounted for 14.9% (95% confidence interval, CI 0%-53.1%) of the variance of BDR, shared environmental effect for 18.4% (95% CI 0%-46.8%), and unshared environmental effect for 66.8% (95% CI 46.8%-88.7%). Conclusion Our twin study showed that individual differences in BDR can be mostly explained by unshared environmental effects. In addition, it is the first study to show low, insignificant hereditary influences, independently from sex, age, and baseline FEV1. PMID:25891875

  11. The Relationship of DNA Methylation with Age, Gender and Genotype in Twins and Healthy Controls

    PubMed Central

    Boks, Marco P.; Derks, Eske M.; Weisenberger, Daniel J.; Strengman, Erik; Janson, Esther; Sommer, Iris E.; Kahn, René S.; Ophoff, Roel A.

    2009-01-01

    Cytosine-5 methylation within CpG dinucleotides is a potentially important mechanism of epigenetic influence on human traits and disease. In addition to influences of age and gender, genetic control of DNA methylation levels has recently been described. We used whole blood genomic DNA in a twin set (23 MZ twin-pairs and 23 DZ twin-pairs, N?=?92) as well as healthy controls (N?=?96) to investigate heritability and relationship with age and gender of selected DNA methylation profiles using readily commercially available GoldenGate bead array technology. Despite the inability to detect meaningful methylation differences in the majority of CpG loci due to tissue type and locus selection issues, we found replicable significant associations of DNA methylation with age and gender. We identified associations of genetically heritable single nucleotide polymorphisms with large differences in DNA methylation levels near the polymorphism (cis effects) as well as associations with much smaller differences in DNA methylation levels elsewhere in the human genome (trans effects). Our results demonstrate the feasibility of array-based approaches in studies of DNA methylation and highlight the vast differences between individual loci. The identification of CpG loci of which DNA methylation levels are under genetic control or are related to age or gender will facilitate further studies into the role of DNA methylation and disease. PMID:19774229

  12. Sister Study

    Cancer.gov

    The Sister Study, conducted by the National Institute of Environmental Health Sciences (NIEHS), is prospectively examining environmental and familial risk factors for breast cancer and other outcomes in a cohort of 50,884 sisters of women who have had breast cancer. These sisters have about twice the risk of developing breast cancer due to their family history and are expected to be highly motivated to participate in a long-term study.

  13. The association between fat and lean mass and bone mineral density: the Healthy Twin Study.

    PubMed

    Park, Joo-Hyun; Song, Yun-Mi; Sung, Joohon; Lee, Kayoung; Kim, Youn Sic; Kim, Taehun; Cho, Sung-Il

    2012-04-01

    The potential beneficial effects of increased body weight on bone mineral density (BMD) conflict with the adverse effects of obesity on various health outcomes, necessitating more specific evaluations of the association between each body component and BMD. In the present study, we evaluated associations of lean mass (LM) and fat mass (FM) with BMD in a Korean sample consisting of a total of 1782 men and women whose mean (standard deviation) age was 43.2 (12.6) years. They were selected from the Healthy Twin Study, a nationwide Korean twin and family study. BMD, FM and LM were measured using dual-energy X-ray absorptiometry. Quantitative genetic analysis and linear mixed analysis were performed with respect to familial relationships and a wide range of probable covariates. Linear mixed analysis revealed that BMD was positively associated with both FM and LM at each region of BMD measurement (whole body, spine, arms, and legs) in men, premenopausal women, and postmenopausal women. However, the association with BMD was stronger for LM than FM. Both LM and FM had positive genetic correlations with BMD at each region, although the correlation with BMD tended to be stronger for LM than FM. Together, these findings suggest that increased LM, rather than FM, is more beneficial for BMD in the Korean population and warrants further study of the common genetic determinants of BMD and body composition. PMID:22306928

  14. UNIVERSITY OF MINNESOTA Twin Cities Campus MILK Study: Mothers and Infants LinKed for Healthy Growth

    E-print Network

    UNIVERSITY OF MINNESOTA Twin Cities Campus MILK Study: Mothers and Infants LinKed for Healthy Growth University of Minnesota Center for Neurobehavioral Development MILK Study 6-Month Visit Details ­ 1 ½ hours and requires no infant feeding or breast milk collection. The visit takes place

  15. SISTER STUDY

    EPA Science Inventory

    The Sister Study will investigate the role of genetic, environmental, and lifestyle factors on the risk of breast cancer and other diseases in sisters of women with breast cancer. This research study will enroll 50,000 women who live in the United States and who are the cancer-fr...

  16. YEAST MEIOSIS Sister kinetochores are mechanically

    E-print Network

    Asbury, Chip

    YEAST MEIOSIS Sister kinetochores are mechanically fused during meiosis I in yeast Krishna K Production of healthy gametes requires a reductional meiosis I division in which replicated sister chromatids comigrate, rather than separate as in mitosis or meiosis II. Fusion of sister kinetochores during meiosis I

  17. Microscopic Particles in Two Fractions of Fresh Cerebrospinal Fluid in Twins with Schizophrenia or Bipolar Disorder and in Healthy Controls

    PubMed Central

    Johansson, Viktoria; Nybom, Rolf; Wetterberg, Lennart; Hultman, Christina M.; Cannon, Tyrone D.; Johansson, Anette G. M.; Ekman, Carl Johan; Landén, Mikael

    2012-01-01

    Background Using scanning electron microscopy, microscopic structures have been identified in fresh cerebrospinal fluid (CSF) in patients with schizophrenia and bipolar disorder, but only rarely in control subjects. However, it has not been determined whether these microscopic particles represent state or trait markers, i.e. if their presence is related to clinical manifestations of the disease or if they also can be found in as yet asymptomatic individuals with a genetic liability. This question can be addressed by studying twins discordant or concordant for schizophrenia or bipolar disorder. Methodology/Principal Findings We investigated microscopic structures in CSF in 102 individuals: 21 monozygotic and 16 dizygotic twins affected or not affected with schizophrenia, schizoaffective disorder or bipolar disorder and in 65 healthy singleton controls. A first and a second fraction of CSF was freshly applied on filters and examined by scanning electron microscopy technique. Spherical particles with lipid appearance averaging between 0.1 to 8.0 µm in diameter were detected in the center of the filter as well as located in the margins of larger aggregates binding in a viscous state. Structures were found in 12 of 17 probands, 5 of 12 healthy co-twins and 3 of 73 healthy controls. Thus, a positive microscopic finding significantly increased the likelihood of belonging to the proband group (OR?=?48, 95% CL: 8.2–550, p<0.0001) and the co-twin-group (OR?=?16, 95% CL: 2.0–218, p?=?0.006). Age, sex, history of alcohol abuse or anxiety syndrome, somatic disorder and markers of acute inflammatory activity did not account for group differences; nor did exposure to psychotropic medication. Conclusion Presence of microscopic particles in CSF may possibly reflect trait dependent genetic or environmental vulnerability in patients with schizophrenia, schizoaffective disorder or bipolar disorder. PMID:23049916

  18. One Sister's Story

    MedlinePLUS

    Skip Navigation Bar Home Current Issue Past Issues One Sister's Story Past Issues / Fall 2006 Table of ... NIH/NIEHS By Tina Hall Sister Study participant One day in April, after my sister returned from ...

  19. Heritability of head motion during resting state functional MRI in 462 healthy twins

    PubMed Central

    Couvy-Duchesne, Baptiste; Blokland, Gabriëlla A. M.; Hickie, Ian B.; Thompson, Paul M.; Martin, Nicholas G.; de Zubicaray, Greig I.; McMahon, Katie L.; Wright, Margaret J.

    2014-01-01

    Head motion (HM) is a critical confounding factor in functional MRI. Here we investigate whether HM during resting state functional MRI (RS-fMRI) is influenced by genetic factors in a sample of 462 twins (65% female; 101 MZ (monozygotic) and 130 DZ (dizygotic) twin pairs; mean age: 21 (SD=3.16), range 16–29). Heritability estimates for three HM components—mean translation (MT), maximum translation (MAXT) and mean rotation (MR)—ranged from 37 to 51%. We detected a significant common genetic influence on HM variability, with about two-thirds (genetic correlations range 0.76–1.00) of the variance shared between MR, MT and MAXT. A composite metric (HM-PC1), which aggregated these three, was also moderately heritable (h2=42%). Using a sub-sample (N=35) of the twins we confirmed that mean and maximum translational and rotational motions were consistent “traits” over repeated scans (r=0.53–0.59); reliability was even higher for the composite metric (r=0.66). In addition, phenotypic and cross-trait cross-twin correlations between HM and resting state functional connectivities (RS-FCs) with Brodmann areas (BA) 44 and 45, in which RS-FCs were found to be moderately heritable (BA44: h2¯=0.23 (sd=0.041), BA45: h2¯=0.26 (sd=0.061)), indicated that HM might not represent a major bias in genetic studies using FCs. Even so, the HM effect on FC was not completely eliminated after regression. HM may be a valuable endophenotype whose relationship with brain disorders remains to be elucidated. PMID:25132021

  20. Heritability of head motion during resting state functional MRI in 462 healthy twins.

    PubMed

    Couvy-Duchesne, Baptiste; Blokland, Gabriëlla A M; Hickie, Ian B; Thompson, Paul M; Martin, Nicholas G; de Zubicaray, Greig I; McMahon, Katie L; Wright, Margaret J

    2014-11-15

    Head motion (HM) is a critical confounding factor in functional MRI. Here we investigate whether HM during resting state functional MRI (RS-fMRI) is influenced by genetic factors in a sample of 462 twins (65% female; 101 MZ (monozygotic) and 130 DZ (dizygotic) twin pairs; mean age: 21 (SD = 3.16), range 16-29). Heritability estimates for three HM components-mean translation (MT), maximum translation (MAXT) and mean rotation (MR)-ranged from 37 to 51%. We detected a significant common genetic influence on HM variability, with about two-thirds (genetic correlations range 0.76-1.00) of the variance shared between MR, MT and MAXT. A composite metric (HM-PC1), which aggregated these three, was also moderately heritable (h(2) = 42%). Using a sub-sample (N = 35) of the twins we confirmed that mean and maximum translational and rotational motions were consistent "traits" over repeated scans (r = 0.53-0.59); reliability was even higher for the composite metric (r = 0.66). In addition, phenotypic and cross-trait cross-twin correlations between HM and resting state functional connectivities (RS-FCs) with Brodmann areas (BA) 44 and 45, in which RS-FCs were found to be moderately heritable (BA44: h(2) = 0.23 (sd = 0.041), BA45: h(2) = 0.26 (sd = 0.061)), indicated that HM might not represent a major bias in genetic studies using FCs. Even so, the HM effect on FC was not completely eliminated after regression. HM may be a valuable endophenotype whose relationship with brain disorders remains to be elucidated. PMID:25132021

  1. Case of early childhood-onset narcolepsy with cataplexy: comparison with a monozygotic co-twin.

    PubMed

    Ito, Hiromichi; Mori, Kenji; Mori, Tatsuo; Goji, Aya; Kagami, Shoji

    2014-10-01

    We describe here a rare case of early childhood-onset (5 years of age) narcolepsy. This case was interesting because of the ability to compare the patient's symptoms to the condition of her healthy monozygotic co-twin sister. The only environmental difference between the co-twins was head injury, which may be associated with the presence of narcolepsy. The co-twin was extroverted, sociable, reliable, and dexterous. In contrast, the patient could be described as introverted, gentle, honest and persevering, but was weak at conversation, assessment of a situation, memory, planning, activity (she was inactive), a sense of time, understanding of an analog clock, operating efficiency, and physical education (due to obesity). The sisters showed the same degree of appetite and dexterity with their fingers. Narcolepsy is often under-recognized or underdiagnosed, especially when the onset occurs in childhood. When we observe preschoolers with excessive daytime sleepiness, we should consider the possibility of narcolepsy with cataplexy. PMID:25336002

  2. Reunited twins: spouse relations / twin research reports / timely topics.

    PubMed

    Segal, Nancy L

    2011-06-01

    The present article explores the social attraction that may evolve on the part of reared apart twins' spouses toward their brothers- and sisters-in-law, that is, their spouses' newly found co-twin. This topic was inspired by the fascinating story of monozygotic reared apart (MZA) twins who were reunited in Perth, Australia in 2008, at age 50. It is followed by brief reviews of twin research articles concerning divorce rates among mothers of multiples and X-chromosome inactivation in MZ female twin pairs. The final section presents informative human interest stories involving twins. PMID:21623660

  3. Healthy co-twins of patients with affective disorders show reduced risk-related activation of the insula during a monetary gambling task

    PubMed Central

    Macoveanu, Julian; Miskowiak, Kamilla; Kessing, Lars Vedel; Vinberg, Maj; Siebner, Hartwig Roman

    2016-01-01

    Background Healthy first-degree relatives of patients with affective disorders are at increased risk for affective disorders and express discrete structural and functional abnormalities in the brain reward system. However, value-based decision making is not well understood in these at-risk individuals. Methods We investigated healthy monozygotic and dizygotic twins with or without a co-twin history of affective disorders (high-risk and low-risk groups, respectively) using functional MRI during a gambling task. We assessed group differences in activity related to gambling risk over the entire brain. Results We included 30 monozygotic and 37 dizygotic twins in our analysis. Neural activity in the anterior insula and ventral striatum increased linearly with the amount of gambling risk in the entire cohort. Individual neuroticism scores were positively correlated with the neural response in the ventral striatum to increasing gambling risk and negatively correlated with individual risk-taking behaviour. Compared with low-risk twins, the high-risk twins showed a bilateral reduction of risk-related activity in the middle insula extending into the temporal cortex with increasing gambling risk. Post hoc analyses revealed that this effect was strongest in dizygotic twins. Limitations The relatively old average age of the mono- and dizygotic twin cohort (49.2 yr) may indicate an increased resilience to affective disorders. The size of the monozygotic high-risk group was relatively small (n = 13). Conclusion The reduced processing of risk magnitude in the middle insula may indicate a deficient integration of exteroceptive information related to risk-related cues with interoceptive states in individuals at familial risk for affective disorders. Impaired risk processing might contribute to increased vulnerability to affective disorders. PMID:26395812

  4. A healthy delivery of twins by assisted reproduction followed by preimplantation genetic screening in a woman with X-linked dominant incontinentia pigmenti

    PubMed Central

    Kim, Myung Joo; Lyu, Sang Woo; Seok, Hyun Ha; Park, Ji Eun

    2014-01-01

    The purpose of this study is to report a successful twin pregnancy and delivery in a female patient with X-linked dominant incontinentia pigmenti (IP) who underwent assisted reproductive technology followed by preimplantation genetic screening (PGS). A 29-year-old female with IP had a previous history of recurrent spontaneous abortion. A molecular analysis revealed the patient had a de novo mutation, 1308_1309insCCCCTTG(p.Ala438ProfsTer26), in the inhibitor of the kappa B kinase gamma gene located in the Xq28 region. IVF/ICSI and PGS was performed, in which male embryos were sexed using array-based comparative genomic hybridization (aCGH). After IVF/ICSI and PGS using aCGH on seven embryos, two euploid male blastocysts were transferred with a 50% probability of a viable male pregnancy. The dizygotic twin pregnancy was confirmed and the amniocentesis results of each twin were normal with regard to the mutation found in the mother. The patient delivered healthy twin babies during the 37th week of gestation. This case shows the beneficial role of PGS in achieving a successful pregnancy through euploid male embryo gender selection in a woman with X-linked dominant IP with a history of multiple male miscarriages. PMID:25599040

  5. Comparison of the Gut Microbiotas of Healthy Adult Twins Living in South Korea and the United States ? †

    PubMed Central

    Lee, Sunghee; Sung, Joohon; Lee, JungEun; Ko, GwangPyo

    2011-01-01

    We compared the composition of the fecal microbiotas of Korean and U.S. adult twins. Our data indicated that the gut microbiota shows some signature of biogeography, potentially mediated by differences in diet and/or other environmental factors; however, these regional differences may be masked by other phenotypic variations, such as obesity. PMID:21873488

  6. Sibling Conversations about Dating and Sexuality: Sisters as Confidants, Sources of Support, and Mentors

    PubMed Central

    Killoren, Sarah E.; Roach, Andrea L.

    2013-01-01

    Using an observational methodology to examine sibling communication, sisters (N = 28 dyads) were videotaped discussing their ideas about dating and sexuality. Social provision theory was used as a framework for the examination of roles enacted by sisters during these conversations. Inductive thematic analytic procedures were conducted and three roles were identified: sisters as confidants, sources of support, and mentors. Older and younger sisters both served as confidants and sources of support for one another, whereas, older sisters were more likely to be mentors for their younger sisters than vice versa. Findings indicate the potential importance of sisters in the formation of adolescent girls’ ideas about romantic relationships and sexuality, sibling communication as a socialization mechanism of sisters’ similarities in romantic experiences and sexual behaviors/attitudes, and the inclusion of older sisters in prevention intervention programs focused on reducing adolescent sexual risk behaviors and promoting healthy romantic relationships and sexuality development. PMID:24659843

  7. Sibling Conversations about Dating and Sexuality: Sisters as Confidants, Sources of Support, and Mentors.

    PubMed

    Killoren, Sarah E; Roach, Andrea L

    2014-04-01

    Using an observational methodology to examine sibling communication, sisters (N = 28 dyads) were videotaped discussing their ideas about dating and sexuality. Social provision theory was used as a framework for the examination of roles enacted by sisters during these conversations. Inductive thematic analytic procedures were conducted and three roles were identified: sisters as confidants, sources of support, and mentors. Older and younger sisters both served as confidants and sources of support for one another, whereas, older sisters were more likely to be mentors for their younger sisters than vice versa. Findings indicate the potential importance of sisters in the formation of adolescent girls' ideas about romantic relationships and sexuality, sibling communication as a socialization mechanism of sisters' similarities in romantic experiences and sexual behaviors/attitudes, and the inclusion of older sisters in prevention intervention programs focused on reducing adolescent sexual risk behaviors and promoting healthy romantic relationships and sexuality development. PMID:24659843

  8. “Do You Want Somebody Treating Your Sister Like That?”: Qualitative Exploration of How African American Families Discuss and Promote Healthy Teen Dating Relationships

    PubMed Central

    Akers, Aletha Y.; Yonas, Michael; Burke, Jessica; Chang, Judy C.

    2011-01-01

    The article discusses a study conducted between December 2007 and March 2008 that involved 19 gender-stratified focus groups with African American parents and adolescents from Allegheny County, Pennsylvania, to explore the process and content of parent–adolescent communication about sex. Discussions about intimate partner violence (IPV) and healthy relationships emerge inductively as critical topics in these conversations. The authors use a grounded theory approach to content analysis to identify and organize themes related to discussions on these topics. A total of 125 participants from 52 families are recruited for the study. Family history of child sexual abuse often motivates discussions. Mothers are described as the primary parent discussing sexual issues with children. Fathers primarily role model ideal male partnership behavior for sons and daughters. Parents seek to prevent daughters from experiencing sexual abuse or emotional manipulation by partners and focus on instilling a sense of responsibility to and respect for romantic partners in sons. Parents prioritize and express the need for tools to influence their adolescent’s socialization as romantic partners. Mothers and fathers approach this process differently. Family-focused interventions to prevent unhealthy relationships can build on parent’s efforts. PMID:20889536

  9. Cysticercosis with an Orbital Tropism in Twins.

    PubMed

    Lee, Bradford W; Kumar, Usha R; Lin, Jonathan H; Amaro, Deirdre E; Kikkawa, Don O; Alameddine, Ramzi M; Lowe, Maureen C; Hilger, Peter A; Vinetz, Joseph M; Korn, Bobby S

    2015-10-01

    Two fraternal twin sisters developed cysticercosis localizing to the right lateral orbit over the same period after a presumed common-source exposure in China. This case demonstrates that cysticercosis can be related to travel. Similar temporal and spatial occurrences of these infections suggest a genetic tropism of the infecting organism in these twins. PMID:26217041

  10. Sister-sister incest: data from an anonymous computerized survey.

    PubMed

    Stroebel, Sandra S; O'Keefe, Stephen L; Griffee, Karen; Kuo, Shih-Ya; Beard, Keith W; Kommor, Martin J

    2013-01-01

    Retrospective data were entered anonymously by 1,521 adult women using a computer-assisted self-interview. Thirty-one participants were victims of sister-sister incest, 40 were victims of brother-sister incest, 19 were victims of father-daughter incest, 8 were victims of sexual abuse by an adult female (including one mother), and 232 were victims of sexual abuse by an adult male other than their father before reaching 18 years of age. The rest (1,203) served as controls. The victims of sister-sister incest had significantly more problematic outcomes than controls on many measures as adults. Victims of sister-sister incest were more depressed and more likely than controls to be distant from the perpetrator-sister and to have traded sex for money, experienced an unplanned pregnancy, engaged in four different types of masturbation, and engaged in 13 different same-sex behaviors. Our findings were consistent with other reports of early eroticization and persistent hypereroticization of incest victims. PMID:23924178

  11. Brothers, Sisters and Aging Parents 

    E-print Network

    Isbell, Lou

    1999-09-02

    and sisters. Judith L. Warren Extension Gerontology Specialist The Texas A&M University System Acknowledgment Adapted with permission from materials originally prepared by Lou Isbell, state special- ist, child and family development, University of Missouri...

  12. Cochlear Implants Keep Twin Sisters Learning, Discovering Together

    MedlinePLUS

    ... Current Issue Past Issues Special Section: Focus on Communication Cochlear Implants Past Issues / Fall 2008 Table of ... from the National Institute on Deafness and Other Communication Disorders (NIDCD), he studies how the language skills ...

  13. Symptomatic colloid cysts in the third ventricle of monozygotic twins

    PubMed Central

    Popek, Edith

    2015-01-01

    In this case report we describe colloid cysts in the third ventricles of monozygotic twin sisters. They were 26 years old when their condition was discovered. One woman was admitted to us on an emergency basis, with signs of high intracranial pressure such as unconsciousness and extension posturing. Her sister was also brought to the hospital since she had a history of attacks of headache. They were both operated with removal of the colloid cysts, and the clinical courses are described in the case report. In reviewing the literature another 30 familial cases were found. Of these were two pairs of monozygotic and one pair of dizygotic twins. PMID:25491677

  14. 78 FR 45061 - Safety Zone; Sister Bay Marina Fest Fireworks and Ski Show, Sister Bay, WI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-26

    ...USCG-2013-0614] RIN 1625-AA00 Safety Zone; Sister Bay Marina Fest Fireworks and Ski Show, Sister Bay, WI AGENCY: Coast Guard, DHS. ACTION: Temporary...establishing a temporary safety zone on Sister Bay near Sister Bay, WI. This safety zone is...

  15. Sister R. Leadership: Doing the Seemingly Impossible

    ERIC Educational Resources Information Center

    Sena, Rachel; Schoorman, Dilys; Bogotch, Ira

    2013-01-01

    Sister R., the first author, is a Dominican Sister of Peace. Until recently, Sister R. had been the director of the Maya Ministry Family Literacy Program, working with the Maya Community in Lake Worth, Palm Beach County, Florida. She described her work with these indigenous, preliterate, hardworking peoples as "a university of the poor" in which…

  16. A monozygotic twin pair with highly discordant Gaucher phenotypes.

    PubMed

    Biegstraaten, M; van Schaik, I N; Aerts, J M F G; Langeveld, M; Mannens, M M A M; Bour, L J; Sidransky, E; Tayebi, N; Fitzgibbon, E; Hollak, C E M

    2011-01-15

    We describe monozygotic twin sisters, born to consanguineous Moroccan parents, who are highly discordant for the manifestations of Gaucher disease. Both carry Gaucher genotype N188S/N188S. One has severe visceral involvement, epilepsy, and a cerebellar syndrome. Her twin does not manifest any symptoms or signs of Gaucher disease but suffers from type 1 diabetes mellitus. The concurrence of a mild Gaucher mutation with a severe phenotype, as well as the occurrence of highly discordant phenotypes in a pair of monozygotic twins, is discussed. PMID:21056933

  17. The sister bonding of duplicated chromosomes

    PubMed Central

    Zou, Hui

    2011-01-01

    Sister chromatid cohesion and separation are two fundamental chromosome dynamics that are essential to equal chromosome segregation during cell proliferation. In this review, I will discuss the major steps that regulate these dynamics during mitosis, with an emphasis on vertebrate cells. The implications of these machineries outside of sister chromatid cohesion and separation are also discussed. PMID:21497666

  18. All in the Family: The Sister Study

    MedlinePLUS

    Skip Navigation Bar Home Current Issue Past Issues All in the Family: The Sister Study Past Issues / ... that may ultimately eliminate this dreaded disease. We all know that breast cancer does not discriminate. Whether ...

  19. Goddard Welcomes SISTER - Duration: 90 seconds.

    NASA Video Gallery

    The Goddard Space Flight Center in Greenbelt, Md., hosted a weeklong summer institute, SISTER, for the purpose of increasing the awareness of and providing opportunities for middle school girls to ...

  20. SCE (SISTER CHROMATID EXCHANGES) ANALYSIS IN LYMPHOCYTES

    EPA Science Inventory

    Expectations are high that sister chromatid exchange analyses in lymphocytes removed from individuals in various occupational settings may serve as monitors of preventable hazardous chemical exposures in much the same way that chromosome aberration analyses have been useful for d...

  1. When Your Brother or Sister Has Cancer

    Cancer.gov

    Tips on what to say to your friends, how to deal with stress, and where to find support – as well as information about cancer and cancer treatments, for young people who have a brother or sister with cancer.

  2. Eruptive history of South Sister, Oregon Cascades

    USGS Publications Warehouse

    Fierstein, J.; Hildreth, W.; Calvert, A.T.

    2011-01-01

    South Sister is southernmost and highest of the Three Sisters, three geologically dissimilar stratovolcanoes that together form a spectacular 20km reach along the Cascade crest in Oregon. North Sister is a monotonously mafic edifice as old as middle Pleistocene, Middle Sister a basalt-andesite-dacite cone built between 48 and 14ka, and South Sister is a basalt-free edifice that alternated rhyolitic and intermediate modes from 50ka to 2ka (largely contemporaneous with Middle Sister). Detailed mapping, 330 chemical analyses, and 42 radioisotopic ages show that the oldest exposed South Sister lavas were initially rhyolitic ~50ka. By ~37ka, rhyolitic lava flows and domes (72-74% SiO2) began alternating with radially emplaced dacite (63-68% SiO2) and andesite (59-63% SiO2) lava flows. Construction of a broad cone of silicic andesite-dacite (61-64% SiO2) culminated ~30ka in a dominantly explosive sequence that began with crater-forming andesitic eruptions that left fragmental deposits at least 200m thick. This was followed at ~27ka by growth of a steeply dipping summit cone of agglutinate-dominated andesite (56-60.5% SiO2) and formation of a summit crater ~800m wide. This crater was soon filled and overtopped by a thick dacite lava flow and then by >150m of dacitic pyroclastic ejecta. Small-volume dacite lavas (63-67% SiO2) locally cap the pyroclastic pile. A final sheet of mafic agglutinate (54-56% SiO2) - the most mafic product of South Sister - erupted from and drapes the small (300-m-wide) present-day summit crater, ending a summit-building sequence that lasted until ~22ka. A 20kyr-long-hiatus was broken by rhyolite eruptions that produced (1) the Rock Mesa coulee, tephra, and satellite domelets (73.5% SiO2) and (2) the Devils Chain of ~20 domes and short coulees (72.3-72.8% SiO2) from N-S vent alignments on South Sister's flanks. The compositional reversal from mafic summit agglutinate to recent rhyolites epitomizes the frequently changing compositional modes of the South Sister locus throughout its lifetime. South Sister is part of a reach of the Cascades unusually active in the last 50kyr, characterized by high vent density, N-S vent alignments, and numerous eruptive units of true rhyolite (? 72% SiO2) that distinguishes it from much of the Quaternary Cascade arc; these are eruptive expressions of the complex confluence of arc and intraplate magmatic-tectonic regimes.

  3. Sympatric populations of sister species of Brachyrhaphis.

    PubMed

    Ingley, S J

    2015-03-01

    The first records of sympatric populations of the poorly studied sister species Brachyrhaphis roseni and Brachyrhaphis terrabensis are presented. Sympatric populations were found in a total of 14 localities in four river drainages throughout the Pacific slopes of western Panama, and they occurred in a wide range of elevations, from 90 to 651 m. These data expand the elevation range of each species, and provide the first case of sympatric sister species within the genus. PMID:25545340

  4. Twin Jet

    NASA Technical Reports Server (NTRS)

    Henderson, Brenda; Bozak, Rick

    2010-01-01

    Many subsonic and supersonic vehicles in the current fleet have multiple engines mounted near one another. Some future vehicle concepts may use innovative propulsion systems such as distributed propulsion which will result in multiple jets mounted in close proximity. Engine configurations with multiple jets have the ability to exploit jet-by-jet shielding which may significantly reduce noise. Jet-by-jet shielding is the ability of one jet to shield noise that is emitted by another jet. The sensitivity of jet-by-jet shielding to jet spacing and simulated flight stream Mach number are not well understood. The current experiment investigates the impact of jet spacing, jet operating condition, and flight stream Mach number on the noise radiated from subsonic and supersonic twin jets.

  5. Neuromyelitis optica (Devic's syndrome) in two sisters.

    PubMed

    Ch'ien, L T; Medeiros, M O; Belluomini, J J; Lemmi, H; Whitaker, J N

    1982-01-01

    Neuromyelitis optica (Devic's syndrome) typically occurs in a sporadic pattern. We studied the disorder in two sisters, ages 6 and 10 years, who presented with sudden loss of vision at age 3 years, followed 5 months later by a transverse myelopathy. The older girl had only light perception in either eye, persistent paraparesis and progressive scoliosis; her sister had a visual acuity of 20/200 in both eyes and mild spinal cord dysfunction. Results of electrodiagnostic tests correlated well with the severity of clinical neurologic deficits and provided objective estimates of the extent of tissue damage in both the optic nerves and the spinal cord. The presence of Devic's syndrome in these two sisters could be coincidental; however, the possibility of a shared genetic factor(s) should be considered. PMID:7067151

  6. Having Twins? How to Stay Healthy

    MedlinePLUS

    ... Ribbon Commands Skip to main content Turn off Animations Turn on Animations Our Sponsors Log in | Register Menu Log in | ... category are mothers with diabetes , those with a history of preterm labor with prior pregnancies, or those ...

  7. Acoustic analysis of intentional vocalizations by autistic and non-autistic monozygotic twins

    E-print Network

    Scoular, Claire

    2008-12-04

    ).This study examine the cries of a young infant who is later diagnosed with autism. Her cries will be compared with those of her identical twin sister who does not later get diagnosed with autism. Trevarthen and Daniel (2005) have used home video tapes...

  8. A circular twin paradox

    NASA Astrophysics Data System (ADS)

    Cranor, Maria B.; Heider, Elizabeth M.; Price, Richard H.

    2000-11-01

    In the special relativistic twin paradox presented here, each twin lives on one ring of a counterrotating pair of infinitesimally separated rings, so that the twins travel on the same circular path but in opposite directions. The observers on the ring of one twin should see the clock of the other twin slowed by time dilation, but at each meeting of the twins symmetry demands that they agree on the amount of time that has passed since their previous meeting. The resolution of the paradox focuses attention on the relation of time dilation to clock synchronization.

  9. Congenital amegakaryocytic thrombocytopenia: a case report of pediatric twins undergoing matched unrelated bone marrow transplantation.

    PubMed

    Rao, Amulya A N; Gourde, Julia A; Marri, Preethi; Galardy, Paul J; Khan, Shakila P; Rodriguez, Vilmarie

    2015-05-01

    Congenital amegakaryocytic thrombocytopenia (CAMT) is a rare inherited disorder that presents with thrombocytopenia in infancy and evolves into bone marrow failure over time. Allogeneic hematopoietic stem cell transplant remains the only curative treatment option. We report our experience with identical twin sisters diagnosed with CAMT and treated successfully with matched unrelated donor bone marrow transplants. Before the transplant, 1 twin developed pancytopenia, whereas the other had a relatively benign clinical course. Choice of conditioning regimens was based on their pretransplant bone marrow cellularity and presence or absence of panyhypoplasia. Both twins tolerated the procedure well with no significant complications. PMID:25171451

  10. Both Twins Traveling Paradox

    NASA Astrophysics Data System (ADS)

    Smarandache, Florentin

    2012-10-01

    Two twins T1 and T2 synchronize their clocks at the same location L, then both of them leave with the same uniform high speed v and on the same large distance d on opposite linear directions to the locations A and respectively B (of course LA = LB = d) on that planet. Each twin sees the other twin moving away from him with the relativistic speed 2v, so each twin considers the other twin younger than him. The time dilation is the same in both twins' inertial reference frames. Here it is a forth symmetry. They stop there at A and respectively at B. Afterwards, the twin T1 from A travels on a linear route back to B (passing through L) at a uniform high speed 2v. Again, each twin sees the other twin traveling towards him with a speed 2v. And again each twin considers the other twin being younger than him, since there is the same time dilation and same space contraction. Again one has a back symmetry. But, when the twin T1 from A gets to B, he finds out that he is younger than the twin T2 in B since he has traveled more that T2.

  11. SISTER CHROMATID EXCHANGES IN MAMMALIAN MEIOTIC CHROMOSOMES

    EPA Science Inventory

    Very little is known about sister chromatid exchanges (SCEs) in meiotic cells--only that they occur (1) and reveal frequency and distribution patterns apparently unaffected by cross-over (CO) exchange conditions in those cells; (2) unfortunately, the number of studies from which ...

  12. Healthy Water, Healthy People.

    ERIC Educational Resources Information Center

    Etgen, John

    2002-01-01

    Describes a hands-on activity, Hitting the Mark, which is found in the "Healthy Water, Healthy People Water Quality Educators Guide" in terms of its objectives, materials, background, procedures, activities, and assessment. (KHR)

  13. Crocodile Talk: Attributions of Incestuously Abused and Nonabused Sisters.

    ERIC Educational Resources Information Center

    Monahan, Kathleen

    1997-01-01

    This qualitative study analyzed the retrospective attributions of adult sisters (five abused sister dyads, and five abused and nonabused sister dyads) who grew up in incestuous families. It examined the attributions of subjects regarding the general sibling group; victim selection and nonselection; and attributions regarding jealousy, protection,…

  14. 77 FR 13585 - Three Sisters Irrigation District; Notice of Application Accepted for Filing and Soliciting...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-07

    ... COMMISSION Three Sisters Irrigation District; Notice of Application Accepted for Filing and Soliciting..., 2012. d. Applicant: Three Sisters Irrigation District. e. Name of Project: Three Sisters Irrigation District Hydroelectric Project. f. Location: The proposed Three Sisters Irrigation District...

  15. Asymmetric twin Dark Matter

    NASA Astrophysics Data System (ADS)

    Farina, Marco

    2015-11-01

    We study a natural implementation of Asymmetric Dark Matter in Twin Higgs models. The mirroring of the Standard Model strong sector suggests that a twin baryon with mass around 5 GeV is a natural Dark Matter candidate once a twin baryon number asymmetry comparable to the SM asymmetry is generated. We explore twin baryon Dark Matter in two different scenarios, one with minimal content in the twin sector and one with a complete copy of the SM, including a light twin photon. The essential requirements for successful thermal history are presented, and in doing so we address some of the cosmological issues common to many Twin Higgs models. The required interactions we introduce predict signatures at direct detection experiments and at the LHC.

  16. Merohedral twins revisited: quinary twins and beyond.

    PubMed

    Quiquandon, Marianne; Gratias, Denis; Sirindil, Abdullah; Portier, Richard

    2016-01-01

    A twin is defined as being an external operation between two identical crystals that share a fraction of the atomic structure with no discontinuity from one crystal to the other. This includes merohedral twins, twins by reticular merohedry as well as coherent twins by contact where only the habit plane is shared by the two adjacent crystals (epitaxy). Interesting and original cases appear when the invariant substructure is built with positions belonging to the same {\\bb Z}-module as, for example, the quinary twin structure first drawn by Albrecht Dürer [(1525). The Painter's Manual: a Manual of Measurement of Lines, Areas and Solids by Means of Compass and Ruler. Facsimile Edition (1977), translated with commentary by W. L. Strauss. New York: Abaris Books]. This paper will show that the Dürer twins, once defined in five-dimensional space, are simple merohedral twins, in the sense of Georges Friedel, leaving the five-dimensional lattice invariant. This analysis will be generalized to some other higher-order {\\bb Z}-modules. PMID:26697867

  17. Twins discordant for myositis and systemic lupus erythematosus show markedly enriched autoantibodies in the affected twin supporting environmental influences in pathogenesis

    PubMed Central

    2014-01-01

    Background Studies of twin pairs discordant for autoimmune conditions provide a unique opportunity to explore contributing factors triggered by complex gene-environment interactions. Methods In this cross-sectional study, thirty-one monozygotic or dizygotic twin pairs discordant for myositis or systemic lupus erythematosus (SLE), along with matched healthy controls were evaluated for antibodies against a panel of 21 autoantigens. Results Autoantibody profiling revealed that 42% of the affected twins showed significant seropositivity against autoantigens in the panel. In many of these affected twins, but none of healthy controls, there were high levels of autoantibodies detected against two or more autoantigens commonly seen in systemic autoimmune diseases including Ro52, Ro60, RNP-70 K and/or RNP-A. In contrast, only 10% (3/31) of the unaffected twins showed seropositivity and these immunoreactivities were against single autoantigens not seen in systemic autoimmune diseases. While no significant differences in autoantibodies were detected between the affected or unaffected twins against thyroid peroxidase, transglutaminase and several cytokines, 23% of the affected twins with myositis showed autoantibodies against the gastric ATPase. Analysis of the monozygotic twins separately also revealed a higher frequencies of autoantibodies in the affected twins compared to the unaffected twins (P?=?0.046). Lastly, clinical analysis of both the affected monozygotic and dizygotic twins revealed that the autoantibody seropositive affected twins had a greater global disease activity score compared to seronegative affected twins (P?=?0.019). Conclusion The findings of significantly more autoantibodies in the affected twins with myositis and SLE compared to the unaffected twins are consistent with potential non-genetic factors playing a role in autoantibody production and pathogenesis of these autoimmune disorders. PMID:24602337

  18. Twin-to-twin transfusion syndrome

    MedlinePLUS Videos and Cool Tools

    ... multiples that share a single placenta containing blood vessels going from one baby to the other. Blood ... transferred to the larger "recipient" twin through interconnecting vessels causing an unequal exchange of blood. The recipient ...

  19. Cognitive processing in monozygotic twins discordant for chronic fatigue syndrome.

    PubMed

    Mahurin, Roderick K; Claypoole, Keith H; Goldberg, Jack H; Arguelles, Lester; Ashton, Suzanne; Buchwald, Dedra

    2004-04-01

    Twenty-one pairs of monozygotic twins discordant for chronic fatigue syndrome (CFS) and 21 matched healthy control (HC) subjects were assessed with 5 untimed tests and 5 timed tests from the computer-based NeuroCognitive Assessment Battery (R. K. Mahurin, 1993). Random effects regression showed no difference between CFS and healthy twins on any of the cognitive tests. Further, the twin groups did not differ from the HC group on any content-dependent measure. In contrast, both sets of twins performed worse than the HC group on all speed-dependent tests except Finger Tapping. Self-rated fatigue and dysphoric mood were only weakly correlated with cognitive performance. These data point toward a shared genetic trait related to information processing that is manifest in the CFS context. The findings have implications for differentiating genetic and acquired vulnerability in the symptomatic expression of the disorder. ((c) 2004 APA, all rights reserved) PMID:15099145

  20. Healthy Mouth, Healthy Body

    MedlinePLUS

    FOR THE DENTAL PATIENT ... Healthy mouth, healthy body T he mouth is a window into the health of the body. It can show signs of nutri- tional ... Sjögren’s syndrome—may first become apparent because of mouth lesions or other oral problems. The mouth is ...

  1. Childbirth, hospitalisation and sickness absence: a study of female twins

    PubMed Central

    Björkenstam, Emma; Alexanderson, Kristina; Narusyte, Jurgita; Kjeldgård, Linnea; Ropponen, Annina; Svedberg, Pia

    2015-01-01

    Objective To investigate associations of giving birth with morbidity in terms of hospitalisation and social consequences of morbidity in terms of sickness absence (SA), while taking familial (genetics and shared environmental) factors into account. Design Prospective register-based cohort study. Estimates of risk of hospitalisation and SA were calculated as HRs with 95% CIs. Setting All female twins, that is, women with a twin sister, born in Sweden. Participants 5118 Swedish female twins (women with a twin sister), born during 1959–1990, where at least one in the twin pair had their first childbirth (T0) during 1994–2009 and none gave birth before 1994. Main outcome measures Hospitalisation and SA during year 3–5 after first delivery or equivalent. Results Preceding the first childbirth, the mean annual number of SA days increased for mothers, and then decreased again. Hospitalisation after T0 was associated with higher HRs of short-term and long-term SA (HR for short-term SA 3.0; 95% CI 2.5 to 3.6 and for long-term SA 2.3; 95% CI 1.6 to 3.2). Hospitalisation both before and after first childbirth was associated with a higher risk of future SA (HR for long-term SA 4.2; 95% CI 2.7 to 6.4). Familial factors influenced the association between hospitalisation and long-term SA, regardless of childbirth status. Conclusions Women giving birth did not have a higher risk for SA than those not giving birth and results indicate a positive health selection into giving birth. Mothers hospitalised before and/or after giving birth had higher risks for future SA, that is, there was a strong association between morbidity and future SA. PMID:25573523

  2. Basal Twinning of Hematite

    NASA Astrophysics Data System (ADS)

    Gonçalves, Fábio; Lagoeiro, Leonardo; Barbosa, Paola

    2013-04-01

    When two crystals share a plane, there is a twinning composition plane. The result is an intergrowth of two separate crystals in a symmetrical manner. Crystallographers classify twinned crystals by a number of twin laws. These twin laws are specific to the crystal system. The type of twinning can be a diagnostic tool in mineral identification and characterization. Many twin laws cannot be recognized in ordinary optical analysis. So, the advent of diffraction techniques to describe punctual crystallographic orientation facilitated the identification of many twinned crystals in rocks. Samples containing hematite of the Quadrilátero Ferrífero, Minas Gerais, Brazil, were analyzed by EBSD technique. Crystallographic orientation data were obtained from automatically indexed EBSD patterns collected on a JEOL JSM-5510. EBSD analysis was carried out on thin sections cut perpendicular to the foliation (XZ plane) and parallel to the stretching lineation (X-direction). Thin sections were polished before EBSD analysis. EBSD patterns were indexed using CHANNEL 5 software from HKL Technology, Oxford Instruments. The resulting data are presented in form of pole figures (upper hemisphere, equal angle, stereographic projection) and of colour-coded maps using Coincidence Site Lattice (? 3) and Twin Boundaries Components. Through electron backscatter diffraction analysis of hematite grains was possible to detect twin boundaries similar to Dauphiné twinning in quartz that is not described for hematite. Dauphiné twinning in trigonal ?-quartz consists of a 60° rotation around the c-axis resulting in a reversal of the crystallographic positive and negative forms (Frondel 1962). As both minerals show similar symmetry, the same mechanism can be described for hematite in this analysis. The basal twinning of hematite developed pervasively during the incipient stage of deformation. This paper investigates the relationships between this kind of twinning, deformation conditions and microstructural modifications in hematite grains. The results show that the presence of twins exerts an important role in the distribution of the intracrystalline plastic deformation in hematite, as well as in the activation of different sets of slip systems. We estimate that basal twin bands can be preferred sites for dynamic recrystallization.

  3. Sister Mary Emil Penet, I.H.M.: Founder of the Sister Formation Conference

    ERIC Educational Resources Information Center

    Glisky, Joan

    2006-01-01

    Mary Emil Penet, I.H.M., (1916-2001) used her talents and charisma to shape the first national organization of American women religious, the Sister Formation Conference (SFC; 1954-1964), facilitating the integrated intellectual, spiritual, psychological, and professional development of vowed women religious. In the decade preceding Vatican II, her…

  4. Tuberculosis: Getting Healthy, Staying Healthy

    MedlinePLUS

    Tuberculosis Getting Healthy, Staying Healthy U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Institute of Allergy and Infectious Diseases Tuberculosis Getting Healthy, Staying Healthy U.S. DEPARTMENT OF HEALTH ...

  5. Regulation of sister chromatid cohesion during the mitotic cell cycle.

    PubMed

    Zheng, Ge; Yu, HongTao

    2015-11-01

    Orderly execution of two critical events during the cell cycle--DNA replication and chromosome segregation--ensures the stable transmission of genetic materials. The cohesin complex physically connects sister chromatids during DNA replication in a process termed sister chromatid cohesion. Timely establishment and dissolution of sister chromatid cohesion is a prerequisite for accurate chromosome segregation, and is tight regulated by the cell cycle machinery and cohesin-associated proteins. In this review, we discuss recent progress in the molecular understanding of sister chromatid cohesion during the mitotic cell cycle. PMID:26511516

  6. 46 CFR 177.210 - Plans for sister vessels.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Plans for sister vessels. 177.210 Section 177.210 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) CONSTRUCTION AND ARRANGEMENT Plans § 177.210 Plans for sister vessels. (a) Plans are not...

  7. 46 CFR 116.210 - Plans for sister vessels.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 4 2012-10-01 2012-10-01 false Plans for sister vessels. 116.210 Section 116.210 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS CARRYING MORE... ARRANGEMENT Plans § 116.210 Plans for sister vessels. (a) Plans are not required for a vessel that is a...

  8. 46 CFR 169.307 - Plans for sister vessels.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Plans for sister vessels. 169.307 Section 169.307 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS SAILING SCHOOL VESSELS Construction and Arrangement Plans § 169.307 Plans for sister vessels. Plans are not required for any...

  9. 46 CFR 116.210 - Plans for sister vessels.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 4 2014-10-01 2014-10-01 false Plans for sister vessels. 116.210 Section 116.210 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS CARRYING MORE... ARRANGEMENT Plans § 116.210 Plans for sister vessels. (a) Plans are not required for a vessel that is a...

  10. 46 CFR 169.307 - Plans for sister vessels.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Plans for sister vessels. 169.307 Section 169.307 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS SAILING SCHOOL VESSELS Construction and Arrangement Plans § 169.307 Plans for sister vessels. Plans are not required for any...

  11. 46 CFR 177.210 - Plans for sister vessels.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Plans for sister vessels. 177.210 Section 177.210 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) CONSTRUCTION AND ARRANGEMENT Plans § 177.210 Plans for sister vessels. (a) Plans are not...

  12. 46 CFR 169.307 - Plans for sister vessels.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Plans for sister vessels. 169.307 Section 169.307 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS SAILING SCHOOL VESSELS Construction and Arrangement Plans § 169.307 Plans for sister vessels. Plans are not required for any...

  13. Fused sister kinetochores initiate the reductional division in meiosis I

    E-print Network

    LETTERS Fused sister kinetochores initiate the reductional division in meiosis I Xuexian Li1 and R. Kelly Dawe1,2,3 During meiosis I the genome is reduced to the haploid content by a coordinated MIS12­NDC80 bridge between sister kinetochores at meiosis I is broken. Kinetochores separate

  14. 46 CFR 169.307 - Plans for sister vessels.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Plans for sister vessels. 169.307 Section 169.307 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS SAILING SCHOOL VESSELS Construction and Arrangement Plans § 169.307 Plans for sister vessels. Plans are not required for any...

  15. 46 CFR 169.307 - Plans for sister vessels.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Plans for sister vessels. 169.307 Section 169.307 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS SAILING SCHOOL VESSELS Construction and Arrangement Plans § 169.307 Plans for sister vessels. Plans are not required for any...

  16. 46 CFR 177.210 - Plans for sister vessels.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Plans for sister vessels. 177.210 Section 177.210 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) CONSTRUCTION AND ARRANGEMENT Plans § 177.210 Plans for sister vessels. (a) Plans are not...

  17. Insights on Solar Twins

    NASA Astrophysics Data System (ADS)

    Sousa Duarte, Tharcisyo Sa e.; Soares da Costa, Jefferson; Dias do Nascimento Júnior, José

    2015-08-01

    The question about how to define a real solar twin are still active. Cayrel de Strobe et al. (1981) defined a solar twin like a star having at the same time the physical parameters, Teff, gravity, bolometric magnitude, microturbulent velocity, and chemical composition. We presented the more extensive sample of solar twins known to date. From these targets we will study the behavior of the solar twins as a function of fundamentals stellar parameters, effective temperature, luminosity, age, convective envelope mass deepening (1 - M*/M?), lithium abundance and rotation period. We selected the solar twins from observations with the spectropolarimeters ESPaDOnS at CFHT and the Narval at TBL and also on literature. All objects have high resolution and high signal to noise. Analyze this sample of solar twins will help us to understand how these stars whether located around of the Sun's place. Our preliminary results show that the lithium abundance presents one clear correlation with stellar age. The (1 - M*/M?) values obtained through our method provided good agreement with the solar value. The rotation periods allow us to assess the solar twins as a function of gyrochronology.

  18. Twin-to-Twin Transfusion Syndrome

    PubMed Central

    Mahieu-Caputo, Dominique; Dommergues, Marc; Delezoide, Anne-Lise; Lacoste, Mireille; Cai, Yi; Narcy, Françoise; Jolly, Dominique; Gonzales, Marie; Dumez, Yves; Gubler, Marie-Claire

    2000-01-01

    The twin-to-twin transfusion syndrome (TTS) results from an unbalanced blood supply through placental anastomoses in monochorionic twins. It induces growth restriction, renal tubular dysgenesis, and oliguria in the donor and visceromegaly and polyuria in the recipient. A better understanding of its pathophysiology could contribute to improving the management of TTS, which still carries a high perinatal mortality in both twins. As well as several other candidates, the renin-angiotensin system might be involved in TTS. To evaluate its role in the pathogenesis of the syndrome, we studied the kidneys of 21 twin pairs who died from TTS at 19 to 30 weeks, compared with 39 individuals in a control group, using light microscopy, immunohistochemistry, and in situ hybridization. The overexpression of the renin protein and transcript with frequent evidence of renin synthesis by mesangial cells was observed in the donor kidneys, presumably as a consequence of chronic renal hypoperfusion. This upregulation of renin synthesis might be beneficial to restore euvolemia. In severe cases of TTS, however, angiotensin-II-induced vasoconstriction acts as an additional deleterious factor by further reducing the renal blood flow in donors. In recipients, renin expression was virtually absent, possibly because it was down-regulated by hypervolemia. However, in addition to congestion and hemorrhagic infarction, there were severe glomerular and arterial lesions resembling those observed in polycythemia- or hypertension-induced microangiopathy. We speculate that fetal hypertension in the recipient might be partly mediated by the transfer of circulating renin produced by the donor, through the placental vascular shunts. PMID:10666392

  19. 77 FR 13585 - Three Sisters Irrigation District; Notice of Application Accepted for Filing and Soliciting...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-07

    ...Project No. 14364-000] Three Sisters Irrigation District; Notice of Application Accepted...2012. d. Applicant: Three Sisters Irrigation District. e. Name of Project: Three Sisters Irrigation District Hydroelectric Project....

  20. Healthy Living

    MedlinePLUS

    ... changes to your lifestyle. By taking steps toward healthy living, you can help reduce your risk of ... Get the screening tests you need Maintain a healthy weight Eat a variety of healthy foods, and ...

  1. Healthy Aging

    MedlinePLUS

    ... News About Us Contact Us Text size | Print | Healthy Aging This information in Spanish ( en español ) A ... Healthy Aging email updates. Enter email address Submit Healthy Aging news Accessibility | Privacy policy | Disclaimers | FOIA | Link ...

  2. HealthyWaterways Healthy Catchments

    E-print Network

    Hilderbrand, Robert H.

    #12;#12;HealthyWaterways Healthy Catchments MAKING THE CONNECTION IN SOUTH EAST QUEENSLAND Collier, Lynda Curtis and Kate Moore Layout by Lone Ranger Creative HEALTHY WATERWAYS i V P>f>r.a\\it=>& Vi Library of Australia Cataloguing-in-Publication data: Healthy Waterways Healthy Catchments: Making

  3. Serial MR imaging and 1H-MR spectroscopy in monozygotic twins with Tay-Sachs disease.

    PubMed

    Imamura, A; Miyajima, H; Ito, R; Orii, K O

    2008-10-01

    Four-year-old monozygotic female twins with early onset Tay-Sachs disease are described. The sisters showed similar slowly progressive clinical symptoms and deterioration, however the younger sister also demonstrated intractable myoclonus in the right leg. The serial MR images and (1)H-MR spectroscopy of the brain were obtained in both twins. MR images showed high intensity on T (2)-weighted image in the bilateral white matter, however there were no signal changes in the basal ganglia and thalamus during any of the phases. The ratio of N-acetylaspartate (NAA)/creatine (Cr) was decreased in the both white matter lesions and the corpus striatum, and that of myoinositol (mI)/Cr was increased in the damaged white matter on MR spectroscopy. The elevation of the lactate peak was clearly demonstrated in the left basal ganglia of the younger sister; however it was not shown in cerebral lesions of the elder sister. Changes in metabolites on MR spectroscopy were closely linked to the respective clinical features of each twin. Follow-up examination by (1)H-MR spectroscopy is useful for the evaluation of neuronal changes in children with Tay-Sachs disease. PMID:19294598

  4. Evolutionary trajectories of hyperdiploid ALL in monozygotic twins.

    PubMed

    Bateman, C M; Alpar, D; Ford, A M; Colman, S M; Wren, D; Morgan, M; Kearney, L; Greaves, M

    2015-01-01

    Identical twins have provided unique insights on timing or sequence of genetic events in acute lymphoblastic leukaemia (ALL). To date, this has mainly focused on ALL with MLL or ETV6-RUNX1 fusions, with hyperdiploid ALL remaining less well characterised. We examined three pairs of monozygotic twins, two concordant and one discordant for hyperdiploid ALL, for single-nucleotide polymorphism (SNP)-defined copy number alterations (CNAs), IGH/L plus TCR gene rearrangements and mutations in NRAS, KRAS, FLT3 and PTPN11 genes. We performed whole exome sequencing in one concordant twin pair. Potential 'driver' CNAs were low, 0-3 per case, and all were different within a pair. One patient had an NRAS mutation that was lacking from leukaemic cells of the twin sibling. By exome sequencing, there were 12 nonsynonymous mutations found in one twin and 5 in the other, one of which in SCL44A2 was shared or identical. Concordant pairs had some identical IGH/L and TCR rearrangements. In the twin pair with discordant hyperdiploid ALL, the healthy co-twin had persistent low level hyperdiploid CD19+ cells that lacked a CNA present in the ALL cells of her sibling. From these data, we propose that hyperdiploid ALL arises in a pre-B cell in utero and mutational changes necessary for clinical ALL accumulate subclonally and postnatally. PMID:24897505

  5. Gene expression profiles in Finnish twins with multiple sclerosis

    PubMed Central

    Särkijärvi, Silja; Kuusisto, Hanna; Paalavuo, Raija; Levula, Mari; Airla, Nina; Lehtimäki, Terho; Kaprio, Jaakko; Koskenvuo, Markku; Elovaara, Irina

    2006-01-01

    Background Since genetic alterations influencing susceptibility to multiple sclerosis (MS), the most common autoimmune demyelinating disease of the central nervous system (CNS), are as yet poorly understood, the purpose of this study was to identify genes responsible for MS by studying monozygotic (MZ) twin pairs discordant for MS. Methods In order to identify genes involved in MS development, the gene expression profiles in blood mononuclear cells obtained from eight MZ twin pairs discordant for MS were analyzed by cDNA microarray technology detecting the expression of 8 300 genes. The twins were collected from the Finnish Twin Cohort Study and both affected subjects and their healthy siblings underwent neurological evaluation and cerebral and spinal magnetic resonance imaging. Gene expressions were confirmed by relative quantitative reverse transcription PCR. Results It appeared that 25 genes were at least two-fold up-regulated and 15 genes down-regulated in 25% (2/8) of twins with MS when compared to their healthy siblings. Moreover, 6/25 genes were up-regulated in 40% of MS twins and one gene, interferon alpha-inducible protein (clone IFI-6-16) (G1P3), in 50% of them. The six most constantly expressed genes are (1) G1P3, (2) POU domain, class 3, transcription factor 1, (3) myxovirus resistance 2, (4) lysosomal-associated multispanning membrane protein-5, (5) hemoglobin alpha 2 and (6) hemoglobin beta. Conclusion Over two-fold up-regulation of these six genes in almost half of MZ twins with MS suggests their role in MS pathogenesis. Studies using MZ MS twins obtained from genetically homogeneous population offer a unique opportunity to explore the genetic nature of MS. PMID:16504146

  6. Familiality of gender identity disorder in non-twin siblings.

    PubMed

    Gómez-Gil, Esther; Esteva, Isabel; Almaraz, M Cruz; Pasaro, Eduardo; Segovia, Santiago; Guillamon, Antonio

    2010-04-01

    Familial studies and reports of co-occurrence of gender identity disorder (GID) within a family may help to clarify the question of whether transsexualism is a familial phenomenon. In a sample of 995 consecutive transsexual probands (677 male-to-female [MF] and 318 female-to-male [FM]), we report 12 pairs of transsexual non-twin siblings (nine pairs of MF siblings, two pairs of MF-FM siblings, and one pair of FM siblings). The present study doubles the number of case reports of co-occurrence of transsexualism in non-twin siblings available in the literature. According to our data, the probability that a sibling of a transsexual will also be transsexual was 4.48 times higher for siblings of MF than for siblings of FM transsexual probands, and 3.88 times higher for the brothers than for the sisters of transsexual probands. Moreover, the prevalence of transsexualism in siblings of transsexuals (1/211 siblings) was much higher than the range expected according to the prevalence data of transsexualism in Spain. The study suggests that siblings of transsexuals may have a higher risk of being transsexual than the general population, and that the risk is higher for brothers than sisters of transsexuals, and for siblings of MF than FM transsexuals. Nevertheless, the risk is low. PMID:19639402

  7. Allergic colitis in monozygotic preterm twins.

    PubMed

    Baldassarre, Maria Elisabetta; Cappiello, Annarita; Laforgia, Nicola; Vanderhoof, Jon

    2013-02-01

    Allergic colitis (AC) typically develops in the first weeks or months of life and is characterized by the presence of red blood in the stools of healthy breastfed or formula fed infants. In this paper, we describe a case of rectal bleeding in monozygotic preterm twins that was resolved with the introduction of a cow's milk protein-free diet (CMPFD). The occurrence of this disorder in monozygotic twins raises the question as to whether the underlying abnormality in the immune regulation, which leads to poor acquisition of tolerance to cow's milk proteins, might be inherited or environmentally acquired. The case also highlights the use of the probiotic Lactobacillus GG (LGG) in the treatment of allergic colitis. PMID:23098248

  8. Difference Between Identical and Fraternal Twins

    MedlinePLUS

    ... Text Size Email Print Share The Difference Between Identical and Fraternal Twins Article Body Because fraternal, or dizygotic, twins are ... a family may see the minor differences in identical twins and declare the twins fraternal based on these ...

  9. Creating Sister Cities: An Exchange Across Hemispheres

    NASA Astrophysics Data System (ADS)

    Adams, M. T.; Cabezon, S. A.; Hardy, E.; Harrison, R. J.

    2008-06-01

    Sponsored by Associated Universities, Inc. (AUI) and the National Radio Astronomy Observatory (NRAO), this project creates a cultural and educational exchange program between communities in South and North America, linking San Pedro de Atacama in Chile and Magdalena, New Mexico in the United States. Both communities have similar demographics, are in relatively undeveloped regions of high-elevation desert, and are located near major international radio astronomy research facilities. The Atacama Large Millimeter/submillimeter Array (ALMA) is just 40 km east of San Pedro; the Very Large Array (VLA) is just 40 km west of Magdalena. In February 2007, the Mayor of San Pedro and two teachers visited Magdalena for two weeks; in July 2007 three teachers from Magdalena will visit San Pedro. These visits enable the communities to lay the foundation for a permanent, unique partnership. The teachers are sharing expertise and teaching methodologies for physics and astronomy. In addition to creating science education opportunities, this project offers students linguistic and cultural connections. The town of San Pedro, Chile, hosts nearly 100,000 tourists per year, and English language skills are highly valued by local students. Through exchanges enabled by email and distance conferencing, San Pedro and Magdalena students will improve English and Spanish language skills while teaching each other about science and their respective cultures. This poster describes the AUI/NRAO Sister Cities program, including the challenges of cross-cultural communication and the rewards of interpersonal exchanges between continents and cultures.

  10. Horsetails are the sister group to all other monilophytes and Marattiales are sister to leptosporangiate ferns.

    PubMed

    Knie, Nils; Fischer, Simon; Grewe, Felix; Polsakiewicz, Monika; Knoop, Volker

    2015-09-01

    The "Monilophyte" clade comprising ferns, horsetails and whisk ferns receives unequivocal support from molecular data as the sister clade to seed plants. However, the branching order of its earliest emerging lineages, the Equisetales (horsetails), the Marattiales, the Ophioglossales/Psilotales and the large group of leptosporangiate ferns has remained dubious. We investigated the mitochondrial nad2 and rpl2 genes as two new, intron-containing loci for a wide sampling of taxa. We found that both group II introns - nad2i542g2 and rpl2i846g2 - are universally present among monilophytes. Both introns have orthologues in seed plants where nad2i542g2 has evolved into a trans-arrangement. In contrast and despite substantial size extensions to more than 5kb in Psilotum, nad2i542g2 remains cis-arranged in the monilophytes. For phylogenetic analyses, we filled taxonomic gaps in previously investigated mitochondrial (atp1, nad5) and chloroplast (atpA, atpB, matK, rbcL, rps4) loci and created a 9-gene matrix that also included the new mitochondrial nad2 and rpl2 loci. We extended the taxon sampling with two taxa each for all land plant outgroups (liverworts, mosses, hornworts, lycophytes and seed plants) to minimize the risk of phylogenetic artefacts. We ultimately obtained a well-supported molecular phylogeny placing Marattiales as sister to leptosporangiate ferns and horsetails as sister to all remaining monilophytes. In addition, an indel in an exon of the here introduced rpl2 locus independently supports the placement of horsetails. We conclude that under dense taxon sampling, phylogenetic information from a prudent choice of loci is currently superior to character-rich phylogenomic approaches at low taxon sampling. As here shown the selective choice of loci and taxa enabled us to resolve the long-enigmatic diversifications of the earliest monilophyte lineages. PMID:25999055

  11. 46 CFR 169.307 - Plans for sister vessels.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...169.307 Section 169.307 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS SAILING SCHOOL VESSELS Construction and Arrangement Plans § 169.307 Plans for sister vessels. Plans are not...

  12. 46 CFR 169.307 - Plans for sister vessels.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...169.307 Section 169.307 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS SAILING SCHOOL VESSELS Construction and Arrangement Plans § 169.307 Plans for sister vessels. Plans are not...

  13. STATISTICAL ANALYSIS OF 'NEANTHES ARENACEODENTATA', SISTER CHROMATID EXCHANGE DATA

    EPA Science Inventory

    This paper presents a statistical evaluation of the sister chromatid exchange (SCE) assay using Neanthes arenaceodentata. Specific issues discussed are distribution of baseline SCE frequencies, transformations of SCE data, statistical sensitivity of the assay, repeatability of te...

  14. Degradation of Drosophila PIM regulates sister chromatid separation during mitosis.

    PubMed

    Leismann, O; Herzig, A; Heidmann, S; Lehner, C F

    2000-09-01

    Drosophila Pimples (PIM) and Three rows (THR) are required for sister chromatid separation in mitosis. PIM accumulates during interphase and is degraded rapidly during mitosis. This degradation is dependent on a destruction box similar to that of B-type cyclins. Nondegradable PIM with a mutant destruction box can rescue sister chromatid separation in pim mutants but only when expressed at low levels. Higher levels of nondegradable PIM, as well as overexpression of wild-type PIM, inhibit sister chromatid separation. Moreover, cells arrested in mitosis before sister chromatid separation (by colcemid or by mutations in fizzy/CDC20) fail to degrade PIM. Thus, although not related by primary sequence, PIM has intriguing functional similarities to the securin proteins of budding yeast, fission yeast, and vertebrates. Whereas these securins are known to form a complex with separins, we show that PIM associates in vivo with THR, which does not contain the conserved separin domain. PMID:10970883

  15. Degradation of Drosophila PIM regulates sister chromatid separation during mitosis

    PubMed Central

    Leismann, Oliver; Herzig, Alf; Heidmann, Stefan; Lehner, Christian F.

    2000-01-01

    Drosophila Pimples (PIM) and Three rows (THR) are required for sister chromatid separation in mitosis. PIM accumulates during interphase and is degraded rapidly during mitosis. This degradation is dependent on a destruction box similar to that of B-type cyclins. Nondegradable PIM with a mutant destruction box can rescue sister chromatid separation in pim mutants but only when expressed at low levels. Higher levels of nondegradable PIM, as well as overexpression of wild-type PIM, inhibit sister chromatid separation. Moreover, cells arrested in mitosis before sister chromatid separation (by colcemid or by mutations in fizzy/CDC20) fail to degrade PIM. Thus, although not related by primary sequence, PIM has intriguing functional similarities to the securin proteins of budding yeast, fission yeast, and vertebrates. Whereas these securins are known to form a complex with separins, we show that PIM associates in vivo with THR, which does not contain the conserved separin domain. PMID:10970883

  16. Degradation of Drosophila PIM regulates sister chromatid separation during mitosis.

    TOXLINE Toxicology Bibliographic Information

    Leismann O; Herzig A; Heidmann S; Lehner CF

    2000-09-01

    Drosophila Pimples (PIM) and Three rows (THR) are required for sister chromatid separation in mitosis. PIM accumulates during interphase and is degraded rapidly during mitosis. This degradation is dependent on a destruction box similar to that of B-type cyclins. Nondegradable PIM with a mutant destruction box can rescue sister chromatid separation in pim mutants but only when expressed at low levels. Higher levels of nondegradable PIM, as well as overexpression of wild-type PIM, inhibit sister chromatid separation. Moreover, cells arrested in mitosis before sister chromatid separation (by colcemid or by mutations in fizzy/CDC20) fail to degrade PIM. Thus, although not related by primary sequence, PIM has intriguing functional similarities to the securin proteins of budding yeast, fission yeast, and vertebrates. Whereas these securins are known to form a complex with separins, we show that PIM associates in vivo with THR, which does not contain the conserved separin domain.

  17. 8. STREAMSIDE PATH NEAR MIDDLE OF THREE SISTERS FALLS, LOOKING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. STREAM-SIDE PATH NEAR MIDDLE OF THREE SISTERS FALLS, LOOKING WEST Photocopy of photograph, 1930s National Park Service, National Capital Region files - Dumbarton Oaks Park, Thirty-second & R Streets Northwest, Washington, District of Columbia, DC

  18. How-to-Do-It: Demonstrating Sister Chromatid Exchanges.

    ERIC Educational Resources Information Center

    Dye, Frank J.

    1988-01-01

    Outlines procedures for demonstrating and preparing a permanent slide of sister chromatid exchanges and recombination events between the two chromatids of a single chromosome. Provides the name of an additional resource for making preparations of exchanges. (RT)

  19. Accommodation at deformation twins in bcc crystals

    NASA Astrophysics Data System (ADS)

    Mahajan, S.

    1981-03-01

    The accommodation processes occurring at terminating twins, twin intersections and grain boundary-twin interactions are reviewed. It is shown that in the three situations, accommodation by slip and twinning can occur. Occasionally, microcracking is observed at a <110> twin intersection and a grain boundary-twin intersection. Argument is developed to reconcile these two sets of observations.

  20. Alloparenting for chimpanzee twins

    PubMed Central

    Kishimoto, Takeshi; Ando, Juko; Tatara, Seiki; Yamada, Nobuhiro; Konishi, Katsuya; Kimura, Natsuko; Fukumori, Akira; Tomonaga, Masaki

    2014-01-01

    In April 2009, a female chimpanzee named Sango, living in a captive group at the Noichi Zoo, Japan, gave birth to dizygotic male-female twin chimpanzees (male: Daiya, female: Sakura). The extent to which adult group members cared for the twins was investigated using a focal animal sampling method targeting six adults (one male) when the twin chimpanzees were two years old. Data were collected for an average of 6.78?h (SD = 0.79) per focal participant. An unaffiliated female adult of Sango was engaged in parenting Sakura as much as Sango. Given that Sakura was in lesser proximity to Sango than Daiya, Sakura's departures from her mother and her ability to gesture requests might have enabled non-kin adults to provide her care. PMID:25200656

  1. Dialysis for twins

    PubMed Central

    Gramkow, Ann-Maria; Aarup, Michael; Andersen, Lise Lotte Torvin; Tepel, Martin

    2014-01-01

    A 32-year-old woman with known stage-4 chronic kidney disease due to lupus nephritis presented with twin pregnancy after in vitro fertilization at a gestational age of 24 weeks + 3 days because of imminent preterm labour. Repeated ultrasound evaluations confirmed intrauterine growth restriction in both twins and polyhydramnios as the cause of imminent preterm labour. After initiation of haemodialysis treatment, ultrasound evaluation showed a significant decrease in amniotic fluids, and also reduction in blood urea nitrogen and in clinical complaints could be observed. At a gestational age of 28 weeks + 4 days, delivery was performed by Caesarean section. This case study shows that effective treatment of elevated uraemic toxins significantly reduced the morbidity risks of the twins. PMID:25859352

  2. Chimerism of buccal membrane cells in a monochorionic dizygotic twin.

    PubMed

    Fumoto, Seiko; Hosoi, Kenichiro; Ohnishi, Hiroaki; Hoshina, Hiroaki; Yan, Kunimasa; Saji, Hiroh; Oka, Akira

    2014-04-01

    No monochorionic dizygotic twins (MCDZTs) with cellular chimerism involving cells other than blood cells have been reported in the literature to date. Here we report a probable first case of MCDZTs with buccal cell chimerism. A 32-year-old woman conceived twins by in vitro fertilization by using 2 cryopreserved blastocysts that were transferred into her uterus. An ultrasound scan at 8 weeks' gestation showed signs indicative of monochorionic twins. A healthy boy and a healthy girl were born, showing no sexual ambiguity. Cytogenetic analyses and microsatellite studies demonstrated chimerism in blood cells of both twins. Notably, repeated fluorescence in situ hybridization and microsatellite studies revealed chimerism in buccal cells obtained from 1 of the twins. Although the mechanism through which buccal cell chimerism was generated remains to be elucidated, ectopic differentiation of chimeric hematopoietic cells that migrated to the buccal membrane or the cellular transfer between the 2 embryos at the early stage of development might be responsible for the phenomenon. This hypothesis raises an interesting issue regarding embryonic development and cellular differentiation into organs during fetal development. Given the possibility of cryptic chimerism in various organs including gonadal tissues in MCDZTs, close observation will be required to determine whether complications develop in the course of the patients' growth. PMID:24685957

  3. Identical twin discordance for the Brachmann-de Lange syndrome revisited

    SciTech Connect

    Carakushansky, G.; Goncalves, M.R.; Kahn, E.

    1996-06-14

    The only known twin pair evidently discordantly affected for the BDLS (Brachmann-de Lange syndrome) and who had been considered monozygotic (MZ) based on blood analysis remained a problem because biological zygosity determination needed further typing. In this report we review the clinical findings of this pair of twins at the age of 20. The use of DNA fingerprinting with three multilocus probes, F10, DNT24, and 33.6, allowed us to present evidence of monozygosity with a high degree of certainty. The significance of this confirmation of discordance in determining the cause of BDLS is discussed. Intensive comparative genomic studies of the discordant twin sisters may be useful to unravel the molecular genetics of this enigmatic pattern of malformation. 21 refs., 2 figs.

  4. On twinning in smectic crystals

    E-print Network

    V. I. Marchenko

    2013-04-26

    It is shown that mechanical twinning in smectic crystals is possible. The structure of the boundary of twins for a small disorientation of crystallites is determined. The periodic twin structure, which should appear at the tension of the smectic layer, is proposed.

  5. Healthy Aging

    MedlinePLUS

    Healthy Aging This category offers tips on how to stay healthy, get good health care, and manage lifestyle changes ... with Smell Problems with Taste Skin Care and Aging Sleep and Aging Taking Medicines Talking with Your ...

  6. Staying Healthy

    MedlinePLUS

    ... Healthy What can people with Alpha-1-related emphysema do to stay as healthy as possible? First ... enzyme that causes the damage that leads to emphysema. If you currently smoke, ask your doctor or ...

  7. Identical Twins Raised Apart

    ERIC Educational Resources Information Center

    Farnsworth, David L.

    2015-01-01

    This article describes a bivariate data set that is interesting to students. Indeed, this particular data set, which involves twins and IQ, has sparked more student interest than any other set that I have presented. Specific uses of the data set are presented.

  8. Twin Higgs WIMP Dark Matter

    E-print Network

    Isabel García García; Robert Lasenby; John March-Russell

    2015-10-02

    Dark matter (DM) without a matter asymmetry is studied in the context of Twin Higgs (TH) theories in which the LHC naturalness problem is addressed. These possess a twin sector related to the Standard Model (SM) by a (broken) $\\mathbb{Z}_2$ symmetry, and interacting with the SM via a specific Higgs portal. We focus on the minimal realisation of the TH mechanism, the Fraternal Twin Higgs, with only a single generation of twin quarks and leptons, and $SU(3)'\\times SU(2)'$ gauge group. We show that a variety of natural twin-WIMP DM candidates are present (directly linked to the weak scale by naturalness), the simplest and most attractive being the $\\tau^\\prime$ lepton with a mass $m_{\\tau^\\prime} > m_{\\rm Higgs}/2$, although spin-1 $W^{\\prime\\pm}$ DM and multicomponent DM are also possible (twin baryons are strongly disfavoured by tuning). We consider in detail the dynamics of the possibly (meta)stable glueballs in the twin sector, the nature of the twin QCD phase transition, and possible new contributions to the number of relativistic degrees of freedom $\\Delta N_{\\rm eff}$. Direct detection signals are below current bounds but accessible in near future experiments. Indirect detection phenomenology is rich and requires detailed studies of twin hadronization and fragmentation to twin glueballs and quarkonia and their subsequent decay to SM, and possible light twin sector states.

  9. Twin Higgs WIMP dark matter

    NASA Astrophysics Data System (ADS)

    García García, Isabel; Lasenby, Robert; March-Russell, John

    2015-09-01

    Dark matter (DM) without a matter asymmetry is studied in the context of twin Higgs (TH) theories in which the LHC naturalness problem is addressed. These possess a twin sector related to the Standard Model (SM) by a (broken) Z2 symmetry, and interacting with the SM via a specific Higgs portal. We focus on the minimal realization of the TH mechanism, the fraternal twin Higgs, with only a single generation of twin quarks and leptons, and the S U (3 )'×S U (2 )' gauge group. We show that a variety of natural twin-WIMP DM candidates are present (directly linked to the weak scale by naturalness), the simplest and most attractive being the ?' lepton with a mass m?'>mHiggs/2 , although spin-1 W'± DM and multicomponent DM are also possible (twin baryons are strongly disfavored by tuning). We consider in detail the dynamics of the possibly (meta)stable glueballs in the twin sector, the nature of the twin QCD phase transition, and possible new contributions to the number of relativistic degrees of freedom, ? Neff . Direct detection signals are below current bounds but accessible in near-future experiments. Indirect detection phenomenology is rich and requires detailed studies of twin hadronization and fragmentation to twin glueballs and quarkonia and their subsequent decay to SM, and possible light twin sector states.

  10. The twin paradox and the principle of relativity

    NASA Astrophysics Data System (ADS)

    Gron, Oyvind

    2013-02-01

    The twin paradox is intimately related to the principle of relativity. Two twins A and B meet, travel away from each other and meet again. From the point of view of A, B is the traveller. Thus, A predicts B to be younger than A herself, and vice versa. Both cannot be correct. The special relativistic solution is to say that if one of the twins, say A, was inertial during the separation, she will be the older one. Since the principle of relativity is not valid for accelerated motion according to the special theory of relativity B cannot consider herself as at rest permanently because she must accelerate in order to return to her sister. A general relativistic solution is to say that due to the principle of equivalence B can consider herself as at rest, but she must invoke the gravitational change of time in order to predict correctly the age of A during their separation. However one may argue that the fact that B is younger than A shows that B was accelerated, not A, and hence the principle of relativity is not valid for accelerated motion in the general theory of relativity either. I here argue that perfect inertial dragging may save the principle of relativity, and that this requires a new model of the Minkowski spacetime where the cosmic mass is represented by a massive shell with radius equal to its own Schwarzschild radius.

  11. Twin Reversed Arterial Perfusion (TRAP) Sequence: A Case Report and Review of Treatment.

    PubMed

    Nanthakomon, Tongta; Chanthasenanont, Athita; Somprasit, Charintip; Manusook, Sakol; Pongrojpaw, Densak; Suwannarurk, Komsun

    2015-04-01

    A cardiac twin or twin reversed arterial perfusion (TRAP) sequence is a rare unique complication of monozygotic multiple pregnancy. In this disorder, there is a normally formed donor (the pump twin) who has features of congestive heart failure (CHF) as well as a recipient (the acardiac twin) who lacks a well-defined a heart structure. Also evident are other structures, namely the TRAP sequencefrom pump to acardiacfetus via single artery-to-artery and vein-to-vein anastomoses directly between the two cords or indirectly on the chorionic plate. Overall, the perinatal mortality rate for the pump twin is 35-55%. Prenatal diagnosis and prognosis factors can be examined through ultrasound. The optimal management of a cardiac twin pregnancies is controversial. The expected treatment of acardiac anomaly presently relies on maximizing the chance ofterm delivery and preventing CHF in the healthy pump twin or interrupting vascularization between the two twins. This article reported the experience of acardiac twin management in Thammasat University Hospital and reviewed the current knowledge ofthe condition, prenatal diagnosis, prognosis factor and management options focusing on conservative management compared to invasive treatment. PMID:26387401

  12. A twin study of cognitive function in chronic fatigue syndrome: the effects of sudden illness onset.

    PubMed

    Claypoole, Keith H; Noonan, Carolyn; Mahurin, Roderick K; Goldberg, Jack; Erickson, Tom; Buchwald, Dedra

    2007-07-01

    Variable reports of neuropsychological deficits in individuals with chronic fatigue syndrome (CFS) may, in part, be attributable to methodological limitations. In this study, these limitations were addressed by controlling for genetic and environmental influences and by assessing the effects of comorbid depression and mode of illness onset. Specifically, the researchers conducted a co-twin control study of 22 pairs of monozygotic twins, in which 1 twin met strict criteria for CFS and the co-twin was healthy. Twins underwent a structured psychiatric interview and comprehensive neuropsychological assessment evaluating 6 cognitive domains. Results indicated that twin groups had similar intellectual and visual memory functioning, but fatigued twins exhibited decreases in motor functions (p = .05), speed of information processing (p = .02), verbal memory (p = .02), and executive functioning (p = .01). Major depression did not affect neuropsychological functioning among fatigued twins, although twins with sudden illness onset demonstrated slowed information processing compared with those with gradual onset (p = .01). Sudden onset CFS was associated with reduced speed of information processing. If confirmed, these findings suggest the need to distinguish illness onset in future CFS studies and may have implications for treatment, cognitive rehabilitation, and disability determination. PMID:17605583

  13. Catholic Sister Nurses in Selma, Alabama, 1940–1972

    PubMed Central

    Wall, Barbra Mann

    2009-01-01

    This study analyzes the activities of religious sister nurses as they confronted racism in the American South from 1940 to 1972. Selma was chosen as a case study because, in the 1960s, events in that southern town marked a turning point in the civil rights movement in the United States. This is a story about the workings of gender, race, religion, and nursing. The sisters’ work demonstrates how an analysis of race in nursing history is incomplete without an understanding of the roles that a number of Catholic religious women took in reaching out to African Americans in the Deep South. PMID:19218843

  14. Catholic sister nurses in Selma, Alabama, 1940-1972.

    PubMed

    Wall, Barbra Mann

    2009-01-01

    This study analyzes the activities of religious sister nurses as they confronted racism in the American South from 1940 to 1972. Selma was chosen as a case study because, in the 1960s, events in that southern town marked a turning point in the civil rights movement in the United States. This is a story about the workings of gender, race, religion, and nursing. The sisters' work demonstrates how an analysis of race in nursing history is incomplete without an understanding of the roles that a number of Catholic religious women took in reaching out to African Americans in the Deep South. PMID:19218843

  15. Twin engine afterbody model

    NASA Technical Reports Server (NTRS)

    Wing, David J.

    1994-01-01

    This test was originally conducted to determine the effects of several empennage and afterbody parameters on the aft-end aerodynamic characteristics of a twin-engine fighter-type configuration. Model variables were as follows: horizontal tail axial location and incidence, vertical tail axial location and configuration (twin-vs single-tail arrangements), tail booms, and nozzle power setting. Jet propulsion was simulated by exhausting high-pressure, cold-flow air from the nozzles. Following a successful test conducted on a single engine nacelle model to validate a CFD code, this model was chosen to be instrumented with pressure taps on the afterbody and nozzles and used as a follow-on test, providing a more complex geometry for the CFD code validation. A more limited test matrix was run to collect the pressure data, employing only the twin-tail configuration and varying only the horizontal and vertical tail locations. Mach number was varied from 0.6 to 1.2. Nozzle pressure ratio was varied from jet-off to 8. Angle-of-attack varied from 0 to 8 deg.

  16. Tribute to dr louis keith: twin and physician extraordinaire/twin research reports: influences on asthma severity; chimerism revisited; DNA strand break repair/media reports: twins born apart; elevated twin frequencies; celebrity father of twins; conjoined twinning.

    PubMed

    Segal, Nancy L

    2014-10-01

    The International Society for Twin Studies has lost a valued friend and colleague. Dr Louis Keith, Emeritus Professor of Obstetrics and Gynecology at Northwestern University, in Chicago, passed away on Sunday, July 6, 2014. His life and work with twins will be acknowledged at the November 2014 International Twin Congress in Budapest, Hungary. Next, twin research reports on the severity of asthma symptoms, a case of chimerism, and factors affecting DNA breakage and repair mechanisms are reviewed. Media reports cover twins born apart, elevated twin frequencies, a celebrity father of twins, and a family's decision to keep conjoined twins together. PMID:25213730

  17. Geologic map of Three Sisters volcanic cluster, Cascade Range, Oregon

    USGS Publications Warehouse

    Hildreth, Wes; Fierstein, Judy; Calvert, Andrew T.

    2012-01-01

    The cluster of glaciated stratovolcanoes called the Three Sisters—South Sister, Middle Sister, and North Sister—forms a spectacular 20-km-long reach along the crest of the Cascade Range in Oregon. The three eponymous stratocones, though contiguous and conventionally lumped sororally, could hardly display less family resemblance. North Sister (10,085 ft), a monotonously mafic edifice at least as old as 120 ka, is a glacially ravaged stratocone that consists of hundreds of thin rubbly lava flows and intercalated falls that dip radially and steeply; remnants of two thick lava flows cap its summit. Middle Sister (10,047 ft), an andesite-basalt-dacite cone built between 48 and 14 ka, is capped by a thick stack of radially dipping, dark-gray, thin mafic lava flows; asymmetrically glaciated, its nearly intact west flank contrasts sharply with its steep east face. Snow and ice-filled South Sister is a bimodal rhyolitic-intermediate edifice that was constructed between 50 ka and 2 ka; its crater (rim at 10,358 ft) was created between 30 and 22 ka, during the most recent of several explosive summit eruptions; the thin oxidized agglutinate that mantles its current crater rim protects a 150-m-thick pyroclastic sequence that helped fill a much larger crater. For each of the three, the eruptive volume is likely to have been in the range of 15 to 25 km³, but such estimates are fairly uncertain, owing to glacial erosion. The map area consists exclusively of Quaternary volcanic rocks and derivative surficial deposits. Although most of the area has been modified by glaciation, the volcanoes are young enough that the landforms remain largely constructional. Furthermore, twelve of the 145 eruptive units on the map are postglacial, younger than the deglaciation that was underway by about 17 ka. The most recent eruptions were of rhyolite near South Sister, about 2,000 years ago, and of mafic magma near McKenzie Pass, about 1,500 years ago. As observed by trailblazing volcanologist, Howel Williams, "For magnificence of glacial scenery, for wealth of recent lavas, and for graphic examples of dissected volcanoes, no part of this range surpasses the area embracing the Sisters and McKenzie Pass." Scientific and journalistic interest in the Three Sisters volcanic cluster was aroused a few years ago when ongoing uplift centered about 5 km west of South Sister was identified, first recognized by satellite imagery in 2001. Subsequent geodetic measurements and continuing satellite imagery analysis confirmed 3 to 4 cm/yr uplift during the interval from 1997 to 2004; the uplift has been modelled as inflation thought to be caused by an intracrustal intrusion, largely aseismic and plausibly involving mafic magma.

  18. Hearing My Mother's Voice: A Study of Sisters and Mothers.

    ERIC Educational Resources Information Center

    Morris, Beverley

    There seems to be an assumption among many people that parents can mold the later adult personality of their offspring by manipulating their childhood upbringing. To tease out the variables in childrearing and to discover some of the sources of the childbearing practices of mothers in the 1980s, a study of sisters and their mothers (N=48) in the…

  19. Clinical Design Sciences: A View from Sister Design Efforts.

    ERIC Educational Resources Information Center

    Zaritsky, Raul; Kelly, Anthony E.; Flowers, Woodie; Rogers, Everett; O'Neill, Patrick

    2003-01-01

    Asserts that the social sciences are clinical-like endeavors, and the way that "sister" fields discover and validate their results may inform research practice in education. Describes three fields of design that confront similar societal demands for improvement (engineering product design, research on the diffusion of innovations, and management…

  20. Sister M. Madeleva Wolff, C.S.C.

    ERIC Educational Resources Information Center

    Petit, M. Loretta

    2006-01-01

    Sister M. Madeleva Wolff, C.S.C., teacher, essayist, poet, and college administrator, through her creative ability and innovative practices made possible major contributions to Catholic education in her lifetime. Without her strong personality and boundless energy, many of her dreams for an ideal college curriculum would not have come to fruition.…

  1. The Three Sisters in the Ge-sar Epic

    E-print Network

    Hummel, Siegbert

    1974-07-23

    is identified with the three sisters. 9. A.H. Fracke, Der Fruhlings- und Wintermythus der Kesar sage (Memoires de la Societe Finno-Ougrienne, XV, Helsingfurs), reprint Osnabruck 1968 (review S. Hummel in; ZMR, 1971, ~): Der Wintermythus, p.46. '10...

  2. Neuroectodermal tumours in the cerebellum in two sisters

    PubMed Central

    Thomas, Myfanwy; Adams, J. Hume; Doyle, David

    1977-01-01

    Two sisters, one 5 years and the other 2 years old, with intrinsic tumours of the cerebellum are reported. One of the tumours was interpreted as being a ganglioneuroma with neuroblastomatous change. The other was a desmoplastic medulloblastoma. Images PMID:599365

  3. Standard sister clade comparison fails when testing derived character States.

    PubMed

    Käfer, Jos; Mousset, Sylvain

    2014-07-01

    Comparing species richness in sister clades that differ in a character state is one of the ways to study factors influencing diversification. While most of its applications have focussed on traits that increase diversification, some have been used to study the association of a trait with lower species richness, e.g., the occurrence of dioecy in flowering plants. We show here, using simulations and an analytical model, that the null expectation of equal species richness that is generally used in sister clade comparisons is wrong in the case of a derived trait occurring independently from speciation: one should expect fewer species in the clade with the derived character state when there is no difference in diversification rates. This is due to the waiting time for the derived state to appear, which causes it to occur more often on longer branches. This has the important implication that the probability for a clade to possess the derived state depends on the tree geometry, and thus on species richness: species-poorer clades are more likely to possess the derived state. We develop a statistical test for sister clade comparisons to study the effect of a derived character state. Applying it to a data set of dioecious clades, we find that we cannot confirm earlier work that concluded that dioecy decreases diversification; on the contrary, it seems to be associated to higher species richness than expected. [angiosperms; dioecy; diversification; sister clades; species richness.]. PMID:24671619

  4. Mitotic toxicity, sister chromatid exchange, and rec assay of pesticides.

    PubMed

    Kuroda, K; Yamaguchi, Y; Endo, G

    1992-07-01

    Genotoxicity of 10 pesticides (chlornitrofen, chlomethoxyfen, molinate, thiobencarb, simazine, simetryn, diazinon, iprofenfos, piperofos and oxadiazone) was studied by mitotic toxicity, sister chromatid exchange, and rec assay. The pesticides are detected frequently at high levels in the Yodo River water in Osaka, Japan, which is used for drinking water by thirteen million people. Mitotic toxicity was evaluated by mitotic index (MI) and second mitosis index (SI), using a Chinese hamster cell line V79. SI is the rate of twice divided metaphases in chromosome preparation for sister chromatid exchange. All the pesticides decreased the two indices dose-dependently. MI50 and SI50, the concentrations of pesticides which lowered the indices to 50% of the solvent control, was determined. The MI50 and SI50 of each pesticide were very similar, and the pesticides did not hinder cell division specifically. None of the pesticides induced more sister chromatid exchanges than 1.5 times the solvent control. Chlomethoxyfen and simazine induced sister chromatid exchanges significantly in V79 cells, but the dose dependencies were poor. Simetryn had rec effect and was concluded to have DNA damaging activity. PMID:1637192

  5. 7. STREAMSIDE PATH BETWEEN THREE BRIDGE FALLS AND THREE SISTERS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. STREAM-SIDE PATH BETWEEN THREE BRIDGE FALLS AND THREE SISTERS FALLS, LOOKING WEST Photocopy of photograph, 1930s National Park Service, National Capital Region files - Dumbarton Oaks Park, Thirty-second & R Streets Northwest, Washington, District of Columbia, DC

  6. TISSUE-SPECIFIC SISTER CHROMATID EXCHANGE ANALYSES IN MUTAGEN-CARCINOGEN EXPOSED ANIMALS

    EPA Science Inventory

    The phenomenon of sister chromatid exchange (SCE) has been extensively reviewed. Sister chromatid exchanges are intrachromosomal events, wherein segments of DNA are reciprocally swapped between the chromatids. They are most easily studied with 5-bromodeoxyuridine (BrdU) dye metho...

  7. Twin classics: research that always inspires/Twin studies: elder twin relationships; Superfecundated twinning in chimpanzees; Conjoined twinning and embryo transfer; Reduced frequency of in vitro multiples/Professional and human interest: first identical twin renal transplant; Identical triplet wedding; Spanakos twins: boxers; Twins in space; Political twins.

    PubMed

    Segal, Nancy L

    2015-08-01

    Ten classic works in twin research are described. These volumes are rich in data, interpretation, and impact, and contain life history material that adds depth and dimension to the quantitative findings. Next, research on social relationships in older twins, superfecundated twinning in chimpanzees; effects of embryo transfer on conjoined twinning and the reduced frequency of in vitro multiples is reviewed. Finally, there has been considerable public interest surrounding the first identical twin renal transplant, an identical triplet wedding; identical twin boxers, a twin living in space, and a politically active twin pair. PMID:26148718

  8. Enjoy Living Healthy Hearts, Healthy Homes

    E-print Network

    Shen, Jun

    Enjoy Living Smoke Free Healthy Hearts, Healthy Homes #12;Read other booklets in the Healthy Hearts, Healthy Homes series: Are You at Risk for Heart Disease? Do You Need To Lose Weight? Do You Know Your Free Delicious Heart Healthy Latino Recipes Healthy Hearts, Healthy Homes NIH Publication No. 08

  9. TWINS Geomagnetic Storm Catalog

    NASA Astrophysics Data System (ADS)

    Perez, J. D.; Buzulukova, N.; Fok, M. C. H.; Goldstein, J.; McComas, D. J.; Valek, P. W.; Wood, K. D.

    2014-12-01

    Results from TWINS 1 & 2 observations and CIMI simulations have been cataloged for geomagnetic storms with Dst or SYM/H below -100 nT in the years 2008-2013. TWINS (Two Wide-angle Imaging Neutral-atom Spectrometers) provides ENA (Energetic Neutral Atom) images on a nearly continuous basis over a broad energy range (1-100 keV/amu). CIMI (Comprehensive Inner-Magnetosphere Ionosphere) model combines the ability to simulate ringcurrent dynamics solving for particle distributions and corresponding ENA fluxes with the ability to calculate radiation belt particle fluxes and inner plasma sheet electron precipitation. For each storm, the TWINS Storm Catalog provides 1-hour-samples ENA images, corresponding deconvolved 2D equatorial ion number flux and pitch angle anisotropy, and the energy spectrum and pitch angle distribution at the position of the peak of the number flux. Also included for direct comparison are results from CIMI simulations for the same quantities. The catalog is available to all interested parties. It will be shown how users of the Catalog will have the opportunity to perform a number of studies related to the dynamics of the ring current during geomagnetic storms. For example, the storms cataloged to date show trends in changes of the energy spectrum from high energy tails deficient in ions as compared to a Maxwellian, to a high energy tail and finally approaching a Maxwellian. Likewise, pitch angle distributions are shown to evolve from having more perpendicular than parallel ions to a nearly isotropic distribution. It is also possible to investigate differences in ring current behavior for CIR and ICME driven storms.It is to be noted that in this context, opportunities for results from the measurements and simulations on a finer time scale, for spectra as a function of equatorial position, and similarly for pitch angle distributions are available by request.

  10. Holographic twin Higgs model.

    PubMed

    Geller, Michael; Telem, Ofri

    2015-05-15

    We present the first realization of a "twin Higgs" model as a holographic composite Higgs model. Uniquely among composite Higgs models, the Higgs potential is protected by a new standard model (SM) singlet elementary "mirror" sector at the sigma model scale f and not by the composite states at m_{KK}, naturally allowing for m_{KK} beyond the LHC reach. As a result, naturalness in our model cannot be constrained by the LHC, but may be probed by precision Higgs measurements at future lepton colliders, and by direct searches for Kaluza-Klein excitations at a 100 TeV collider. PMID:26024160

  11. 40 CFR 79.65 - In vivo sister chromatid exchange assay.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... references should be consulted. (1) 40 CFR 798.5915, In vivo Sister Chromatid Exchange Assay. (2) Kato, H... In vivo sister chromatid exchange assay. (a) Purpose. The in vivo sister chromatid exchange (SCE... number of SCE for each metaphase. Differences among animals within each group shall be considered...

  12. The early parenting of twins.

    PubMed

    Thomas, J G

    1996-04-01

    The anticipatory guidance for the parents of twins involves information on feeding, the parent-twin relationship, and promoting a sense of self. Parents optimally attach to one infant only, a concept known as monotropy. Ambivalence, anxiety, and unequal attachments may result from the stressful nature of raising twins. The early diagnosis of twins, visualization via ultrasound, and postpartum identification of the distinctive aspects of each infant help establish separate bonds. This individualization promotes a sense of self, self-esteem, and enhances individuation, the process by which the personality is differentiated, developed, and expressed. The twin situation is triadic; the infants develop attachments to the primary care giver and their co-twin. Problems with this complex association include delayed onset of speech, decreased speech production, and cryptophasia (secret language) between twins. Strategies to prevent speech delay include as much one-on-one time as possible and consistent intervention and correction of speech errors. Anticipatory guidance seeks to identify potential sources of stress with the goal of seeking out advice, accepting any assistance offered, and attending to twins at the desired level of individualization. PMID:8935514

  13. Transformation: From Twin to Individual

    ERIC Educational Resources Information Center

    Magagna, Jeanne

    2007-01-01

    This article explores some of the complexities of psychotherapy with an identical twin. The difficulty of developing in psychotherapy while so much of what is oneself is located in the other twin will also be explored. The use of the countertransference as a therapeutic method will be considered as the young person develops her unique, separate…

  14. Healthy ABCs

    MedlinePLUS

    ... Donate Stocks Close www.diabetes.org > Living With Diabetes > Complications > Heart Disease Share: Print Page Text Size: A ... heart-and-circulation, In this section Living With Diabetes Complications Heart Disease Healthy ABCs Types of Heart Disease ...

  15. Healthy Eyes

    MedlinePLUS

    ... los Ojos Cómo hablarle a su oculista Healthy Eyes Listen Having a comprehensive dilated eye exam is ... or contact lenses. What is a comprehensive dilated eye exam? A comprehensive dilated eye exam is a ...

  16. Healthy Eyes

    MedlinePLUS

    ... of this page please turn Javascript on. Healthy Eyes Maintaining Your Vision Click for more information Taking ... have a comprehensive dilated eye exam. Who Performs Eye Exams? An eye care professional is either an ...

  17. Size effects in twinned nanopillars

    NASA Astrophysics Data System (ADS)

    Hammami, Farah; Kulkarni, Yashashree

    2014-07-01

    Nanotwinned structures are becoming increasingly attractive owing to their potential as optimal motifs for strength, ductility, and grain stability in metals. In this work, we use nanopillar compression as a paradigmatic problem to investigate the interplay between size effects associated with the twin spacing and the finite size of the nanopillars by way of molecular dynamics simulations. Our simulations reveal that the aspect ratio plays an important role in governing the weakening or strengthening effect of coherent twin boundaries under uniaxial compression. We find that there exists an optimal aspect ratio for which the yield strength of twinned nanopillars is slightly higher than even single crystal nanopillars. In addition, we observe that twin boundaries facilitate dislocation-starvation as defects glide along twin boundaries and are eliminated at the free surface.

  18. Twins and Kindergarten Separation: Divergent Beliefs of Principals, Teachers, Parents, and Twins

    ERIC Educational Resources Information Center

    Gordon, Lynn Melby

    2015-01-01

    Should principals enforce mandatory separation of twins in kindergarten? Do school separation beliefs of principals differ from those of teachers, parents of twins, and twins themselves? This survey questioned 131 elementary principals, 54 kindergarten teachers, 201 parents of twins, and 112 twins. A majority of principals (71%) believed that…

  19. Best Practices for Twin Placement in School

    ERIC Educational Resources Information Center

    Lacina, Jan

    2012-01-01

    The children's book "Two Is for Twins" celebrates twins and illustrates the many "twos" in a child's world. The uniqueness of twos does not have to mean separate classrooms for twins in child development programs, preschool, or elementary school settings. With recent dramatic increases in the US twin population, how should educators address the…

  20. The Genetic Relationship between Indentical Twins.

    ERIC Educational Resources Information Center

    Herman, Rosemary

    1984-01-01

    Reviews current research on a woman's chances of bearing twins and the genetic relationship, prenatal competition, and personality similarities between twins. In addition, the nature/nurture controversy is discussed in terms of evidence from studies of identical twins reared apart. Future studies are suggested to discover the ways twinning might…

  1. Sister chromatid junctions in the hyperthermophilic archaeon Sulfolobus solfataricus

    PubMed Central

    Robinson, Nicholas P; Blood, Katherine A; McCallum, Simon A; Edwards, Paul A W; Bell, Stephen D

    2007-01-01

    Although the Archaea exhibit an intriguing combination of bacterial- and eukaryotic-like features, it is not known how these prokaryotic cells segregate their chromosomes before the process of cell division. In the course of our analysis of the third replication origin in the archaeon Sulfolobus solfataricus, we identify and characterise sister chromatid junctions in this prokaryote. This pairing appears to be mediated by hemicatenane-like structures, and we provide evidence that these junctions persist in both replicating and postreplicative cells. These data, in conjunction with fluorescent in situ hybridisation analyses, suggest that Sulfolobus chromosomes have a significant period of postreplicative sister chromatid synapsis, a situation that is more reminiscent of eukaryotic than bacterial chromosome segregation mechanisms. PMID:17255945

  2. Twin Higgs Asymmetric Dark Matter.

    PubMed

    García García, Isabel; Lasenby, Robert; March-Russell, John

    2015-09-18

    We study asymmetric dark matter (ADM) in the context of the minimal (fraternal) twin Higgs solution to the little hierarchy problem, with a twin sector with gauged SU(3)^{'}×SU(2)^{'}, a twin Higgs doublet, and only third-generation twin fermions. Naturalness requires the QCD^{'} scale ?_{QCD}^{'}?0.5-20??GeV, and that t^{'} is heavy. We focus on the light b^{'} quark regime, m_{b^{'}}??_{QCD}^{'}, where QCD^{'} is characterized by a single scale ?_{QCD}^{'} with no light pions. A twin baryon number asymmetry leads to a successful dark matter (DM) candidate: the spin-3/2 twin baryon, ?^{'}?b^{'}b^{'}b^{'}, with a dynamically determined mass (?5?_{QCD}^{'}) in the preferred range for the DM-to-baryon ratio ?_{DM}/?_{baryon}?5. Gauging the U(1)^{'} group leads to twin atoms (?^{'}-?^{'}[over ¯] bound states) that are successful ADM candidates in significant regions of parameter space, sometimes with observable changes to DM halo properties. Direct detection signatures satisfy current bounds, at times modified by dark form factors. PMID:26430985

  3. Twin methodology in epigenetic studies.

    PubMed

    Tan, Qihua; Christiansen, Lene; von Bornemann Hjelmborg, Jacob; Christensen, Kaare

    2015-01-01

    Since the final decades of the last century, twin studies have made a remarkable contribution to the genetics of human complex traits and diseases. With the recent rapid development in modern biotechnology of high-throughput genetic and genomic analyses, twin modelling is expanding from analysis of diseases to molecular phenotypes in functional genomics especially in epigenetics, a thriving field of research that concerns the environmental regulation of gene expression through DNA methylation, histone modification, microRNA and long non-coding RNA expression, etc. The application of the twin method to molecular phenotypes offers new opportunities to study the genetic (nature) and environmental (nurture) contributions to epigenetic regulation of gene activity during developmental, ageing and disease processes. Besides the classical twin model, the case co-twin design using identical twins discordant for a trait or disease is becoming a popular and powerful design for epigenome-wide association study in linking environmental exposure to differential epigenetic regulation and to disease status while controlling for individual genetic make-up. It can be expected that novel uses of twin methods in epigenetic studies are going to help with efficiently unravelling the genetic and environmental basis of epigenomics in human complex diseases. PMID:25568460

  4. Twin Higgs Asymmetric Dark Matter

    E-print Network

    Isabel García García; Robert Lasenby; John March-Russell

    2015-09-16

    We study Asymmetric Dark Matter (ADM) in the context of the minimal (Fraternal) Twin Higgs solution to the little hierarchy problem, with a twin sector with gauged $SU(3)' \\times SU(2)'$, a twin Higgs, and only third generation twin fermions. Naturalness requires the QCD$^\\prime$ scale $\\Lambda'_{\\rm QCD} \\simeq 0.5 - 20 \\ {\\rm GeV}$, and $t'$ to be heavy. We focus on the light $b'$ quark regime, $m_{b'} \\lesssim \\Lambda'_{\\rm QCD}$, where QCD$^\\prime$ is characterised by a single scale $\\Lambda'_{\\rm QCD}$ with no light pions. A twin baryon number asymmetry leads to a successful DM candidate: the spin-3/2 twin baryon, $\\Delta' \\sim b'b'b'$, with a dynamically determined mass ($\\sim 5 \\Lambda'_{\\rm QCD}$) in the preferred range for the DM-to-baryon ratio $\\Omega_{\\rm DM}/\\Omega_{\\rm baryon} \\simeq 5$. Gauging the $U(1)'$ group leads to twin atoms ($\\Delta'$ - $\\bar {\\tau'}$ bound states) that are successful ADM candidates in significant regions of parameter space, sometimes with observable changes to DM halo properties. Direct detection signatures satisfy current bounds, at times modified by dark form factors.

  5. Two sisters with Reed's syndrome: treatment with pregabalin.

    PubMed

    Yaldiz, Mahizer; Metin, Murcan; Erdem, Mustafa Teoman; Dikicier, Bahar Sevimli; Kahyaoglu, Zeynep

    2015-01-01

    Cutaneous leiomyomas, which originate in the arrector pili muscles of the skin are rarely seen benign cutaneous tumors. Sometimes familial cutaneous and uterine leiomyomatosis can occur together, an autosomal dominant genetic condition called Reed syndrome or familial leiomyomatosis cutis et uteri. This disorder can be accompanied by malignancies, particularly by renal carcinoma. In this paper, two sisters with Reed syndrome are presented in view of the rarity of the disorder and good response to pregabalin therapy. PMID:26437289

  6. Sister chromatid exchanges in lymphocytes of petroleum retailers.

    PubMed Central

    Edwards, J W; Priestly, B G

    1993-01-01

    Occupational exposure to petroleum vapour was assessed in workers employed in suburban petroleum retail outlets. Urinary output of thioethers provided a non-specific estimate of exposure to chemicals metabolised via a mercapturic acid pathway. Urinary d-glucaric acid (DGA) excretion was taken as an estimate of hepatic enzyme activity. Sister chromatid exchange frequency in lymphocytes was used as an indicator of genotoxic response to exposure. Workers were classified according to their employment at self service (where customers operate petrol pumps) or at driveway attended service stations (at which an employee operates the pumps), and according to exposure to cigarette smoke on the basis of urinary cotinine excretion. Prework and postwork urine samples of workers employed at driveway attended petrol stations contained more thioether than did those of self serve workers. When classified according to smoking behaviour there were no statistically significant differences, although thioether excretion tended to be higher in smokers than in nonsmokers. Urinary DGA excretion was similar in the two exposure groups. Cigarette smokers excreted more DGA, however, than nonsmokers. Sister chromatid exchange frequencies were higher in driveway attendants than in self serve personnel. When the influence of cigarette smoking was investigated there was a significant increase of sister chromatid exchange with combined exposure to petrol and cigarette smoking, but not with either factor alone. Correlation analysis showed that urinary cotinine concentrations were positively associated with urinary excretion of thioether and DGA, indicating that cigarette smoke induces the activity of hepatic enzymes and acts as a source of substrates metabolised through a thioether pathway. In conclusion it seems that exposure to petroleum vapour causes increased sister chromatid exchange in circulating lymphocytes of cigarette smokers, possibly as a result of enhanced hepatic conversion of vapour components to reactive metabolites. Urinary thioether output does not clearly discriminate between workers exposed to different amounts of petroleum vapour at retail outlets. PMID:8435347

  7. Centenary Celebration for Scottish Missionary Mary Slessor: A Lasting Legacy for Twins/Twin Research: Twins With Kleinfelter's Syndrome; Twin Research on Atopic Diseases; Twin Study of Autism; Psychotherapy with Twins / General Interest: Female Twin Pole-Vaulters; Longest Twin Birth Interval; Pair of Franco-Cuban Vocalists; Croatian Twin Models.

    PubMed

    Segal, Nancy L

    2015-06-01

    The centenary celebration for Scottish missionary, Mary Slessor, took place on February 14, 2015 in Melle, Belgium. Slessor saved many newborn twins and their mothers from death and disownment by members of their community, including their families, who believed twins harbored evil spirits. The events of this unusual and significant gathering are described. Next, twin research and reports concerning Kleinfelter's disease, atopic diseases, autism and psychotherapy are presented. General interest subjects include identical female twin pole-vaulters, the longest twin birth interval, Franco-Cuban twin vocalists, and Croatian twin models. PMID:25906830

  8. Malignant Triton Tumors in Sisters with Clinical Neurofibromatosis Type 1

    PubMed Central

    Alina, Basnet; Sebastian, Jofre A.; Gerardo, Capo

    2015-01-01

    Malignant triton tumors (MTTs) are rare and aggressive sarcomas categorized as a subgroup of malignant peripheral nerve sheath tumors (MPNSTs). MTTs arise from Schwann cells of peripheral nerves or existing neurofibromas and have elements of rhabdomyoblastic differentiation. We report the occurrence of MTTs in two sisters. The first patient is a 36-year-old female who presented with left sided chest wall swelling. She also had clinical features consistent with neurofibromatosis type 1 (NF-1). Debulking of the mass showed high-grade malignant peripheral nerve sheath tumor with skeletal muscle differentiation (MTT). The patient was treated with ifosfamide and adriamycin along with radiation. Four years after treatment, she still has no evidence of disease recurrence. Her sister subsequently presented to us at the age of 42 with left sided lateral chest wall pain. Imaging showed a multicompartmental retroperitoneal cystic mass with left psoas involvement. The tumor was resected and, similarly to her sister, it showed high-grade malignant peripheral nerve sheath tumor with rhabdomyoblastic differentiation (MTT). The patient was started on chemotherapy and radiation as described above. PMID:26114002

  9. Failure of vincristine induce twinning

    NASA Technical Reports Server (NTRS)

    Binder, M.

    1984-01-01

    Mammalian ova do not contain axes of symmetry from which are derived embryonic axes of symmetry. Mammalian axis determination is an early embryologic event occurring at about the time that monozygous twinning in mice. (Kaufma MH & O'Shea KS, 1978, Nature 276:707) and an attempt was made to reproduce their work in several strains of mice. Over 3200 embryos were examined without any twins being found. To rule out the possibility that vincristine caused twinning plus some lethal malformation (with subsequent resorption of the embryo) the embryos were examined 36-60 hours after vincristine treatment.

  10. Twin paradox in compact spaces

    NASA Astrophysics Data System (ADS)

    Barrow, John D.; Levin, Janna

    2001-04-01

    Twins traveling at constant relative velocity will each see the other's time dilate leading to the apparent paradox that each twin believes the other ages more slowly. In a finite space, the twins can both be on inertial, periodic orbits so that they have the opportunity to compare their ages when their paths cross. As we show, they will agree on their respective ages and avoid the paradox. The resolution relies on the selection of a preferred frame singled out by the topology of the space.

  11. Mechanism of slip and twinning

    NASA Technical Reports Server (NTRS)

    Rastani, Mansur

    1992-01-01

    The objectives are to: (1) demonstrate the mechanisms of deformation in body centered cubic (BCC), face centered cubic (FCC), and hexagonal close-packed (HCP)-structure metals and alloys and in some ceramics as well; (2) examine the deformed microstructures (slip lines and twin boundaries) in different grains of metallic and ceramic specimens; and (3) study visually the deformed macrostructure (slip and twin bands) of metals and alloys. Some of the topics covered include: deformation behavior of materials, mechanisms of plastic deformation, slip bands, twin bands, ductile failure, intergranular fracture, shear failure, slip planes, crystal deformation, and dislocations in ceramics.

  12. Mechanism of slip and twinning

    NASA Astrophysics Data System (ADS)

    Rastani, Mansur

    1992-06-01

    The objectives are to: (1) demonstrate the mechanisms of deformation in body centered cubic (BCC), face centered cubic (FCC), and hexagonal close-packed (HCP)-structure metals and alloys and in some ceramics as well; (2) examine the deformed microstructures (slip lines and twin boundaries) in different grains of metallic and ceramic specimens; and (3) study visually the deformed macrostructure (slip and twin bands) of metals and alloys. Some of the topics covered include: deformation behavior of materials, mechanisms of plastic deformation, slip bands, twin bands, ductile failure, intergranular fracture, shear failure, slip planes, crystal deformation, and dislocations in ceramics.

  13. Twin-to-twin transfusion syndrome: a comprehensive update.

    PubMed

    Habli, Mounira; Lim, Foong Yen; Crombleholme, Timothy

    2009-06-01

    Twin-to-twin transfusion syndrome (TTTS) is a serious complication in about 10% to 20% of monozygous twin gestations with an incidence of 4% to 35% in the United States. Severe TTTS is reported to occur in 5.5% to 17.5% of cases. TTTS is a progressive disease in which sudden deteriorations in clinical status can occur, leading to death of a co-twin. Up to 30% of survivors may have abnormal neurodevelopment as a result of the combination of profound antenatal insult and the complications of severe prematurity. This article presents an overview of what is known about the pathophysiology and the diagnosis of TTTS, the role of echocardiography in TTTS, treatment options available for TTTS, complications of treatment for TTTS, and short- and long-term outcomes of TTTS. PMID:19559327

  14. Healthy Learning.

    ERIC Educational Resources Information Center

    Kennedy, Mike

    2003-01-01

    Offers ten suggestions for schools and universities to help maintain a healthy indoor environment: proper flooring, sanitary washrooms, consistent maintenance, indoor air quality, preventing mold, daylighting, good acoustics, avoiding volatile organic compounds (VOCs), ergonomic furniture, and well-maintained roofs. (EV)

  15. Menkes disease with discordant phenotype in female monozygotic twins.

    PubMed

    Burgemeister, Anna Lena; Zirn, Birgit; Oeffner, Frank; Kaler, Stephen G; Lemm, Gunther; Rossier, Eva; Büttel, Hans-Martin

    2015-11-01

    Menkes disease (MD) is a rare X-linked recessive disorder caused by mutations in the ATP7A gene. This neurodegenerative disorder typically affects males and is characterized by impaired copper distribution and the malfunction of several copper-dependent enzymes. We report clinically discordant female monozygotic twins (MZT) with a heterozygous ATP7A mutation. One twin girl is healthy at the current age of 4 years, whereas the other twin girl developed classical MD, showed disease stabilization under copper histidine treatment but died at the age of 3 years. Presumably, the affected girl developed MD due to skewed X inactivation, although this could not be demonstrated in two tissues (blood, buccal mucosa). This case is a rare example of an affected girl with MD and shows the possibility of a discordant phenotype in MZT girls. As speculated in other X-linked diseases, the process of monozygotic twinning may be associated with skewed X inactivation leading to a discordant phenotype. © 2015 Wiley Periodicals, Inc. PMID:26239182

  16. Twin Higgs Asymmetric Dark Matter

    NASA Astrophysics Data System (ADS)

    García García, Isabel; Lasenby, Robert; March-Russell, John

    2015-09-01

    We study asymmetric dark matter (ADM) in the context of the minimal (fraternal) twin Higgs solution to the little hierarchy problem, with a twin sector with gauged SU(3)'×SU(2)', atwin Higgs doublet, and only third-generation twin fermions. Naturalness requires the QCD' scale ?QCD'?0.5 - 20 GeV , and that t' is heavy. We focus on the light b' quark regime, mb'??QCD', where QCD' is characterized by a single scale ?QCD' with no light pions. A twin baryon number asymmetry leads to a successful dark matter (DM) candidate: the spin-3 /2 twin baryon, ?'˜b'b'b', with a dynamically determined mass (˜5 ?QCD') in the preferred range for the DM-to-baryon ratio ?DM/?baryon?5 . Gauging the U (1 )' group leads to twin atoms (?'-?' ¯ bound states) that are successful ADM candidates in significant regions of parameter space, sometimes with observable changes to DM halo properties. Direct detection signatures satisfy current bounds, at times modified by dark form factors.

  17. Twin research, revisionism and metahistory.

    PubMed

    Teo, Thomas; Ball, Laura C

    2009-12-01

    We understand metahistory as an approach that studies how histories within a particular discipline have been written and focus on insider scientists' reconstructions of twin research. Using the concept of ethical-political affordances we suggest that such histories are based on a management of resources that prove to be beneficial for representing one's own research traditions in a positive light. Instead of discussing information on the context and intellectual life of pioneers of the twin method, which include high-caliber eugenicists and Nazi ideologues, and on how the twin method has been used and abused, insider scientists' accounts present twin research as neutral, objective and void of any kind of political connotations. We show how important leaders of German twin research have been historically managed, and how their contributions have been distorted and omitted. Reasons for historical revisionism by omission and for selectively revised accounts of the past are discussed. Suggestions for writing accounts of the twin method are included and focus on the necessity of self-reflection, considerations regarding one's own ethical-political inclinations, and review of the existing historical literature. In analyzing these connections, we attempt to understand how science, politics and history interact. PMID:20419900

  18. Post-operative Streptococcus pneumoniae meningoencephalitis complicating surgery for acromegaly in an identical twin.

    PubMed

    Cote, David J; Iuliano, Sherry L; Smith, Timothy R; Laws, Edward R

    2015-06-01

    This case report provides provocative and useful data regarding two aspects of acromegaly and its management. The patient, who is one of a pair of identical twins, has no known hereditary, genetic or otherwise potentially etiologic factors as compared to her unaffected sister. Secondly, transsphenoidal surgery, which was ultimately successful, was complicated by pneumococcal meningitis, an unusual event with only four previously reported patients, three of whom ended in death or major neurologic deficits. In this case, a 57-year-old woman gradually developed classical signs and symptoms of acromegaly while her identical twin sister remained normal with no evidence of endocrine disease. Endoscopic transsphenoidal surgery was complicated by the development of meningitis 25 days after surgery. This was controlled following a difficult hospital course. Streptococcus pneumoniae meningoencephalitis is a rare but life-threatening complication of transsphenoidal surgery. A high index of suspicion for incipient meningitis should be maintained when patients present with severe headache and increased intracranial pressure, even if they initially lack the typical symptoms and signs. Immediate and aggressive treatment is necessary to avoid significant neurologic deficit. PMID:25861890

  19. Twin Dimples Intrigue Scientists

    NASA Technical Reports Server (NTRS)

    2004-01-01

    This image from the Mars Exploration Rover Opportunity is part of the first set of pictures that was returned to Earth after the rover exited 'Eagle Crater.' Scientists are busy analyzing Opportunity's new view of the plains of Meridiani Planum. The plentiful ripples are a clear indication that wind is the primary geologic process currently in effect on the plains. On the left of the image are two depressions--each about a meter (about 3.3 feet) across--that feature bright spots in their centers. One possibility is that the bright material is similar in composition to the rocks in Eagle Crater's outcrop and the surrounding darker material is what's referred to as 'lag deposit,' or erosional remnants that are much harder and more difficult to wear away. These twin dimples might be revealing pieces of a larger outcrop that lies beneath. The depression closest to Opportunity is whimsically referred to as 'Homeplate' and the one behind it as 'First Base.' The rover's panoramic camera is set to take detailed images of the depressions today, on Opportunity's 58th sol. The backshell and parachute that helped protect the rover and deliver it safely to the surface of Mars are also visible near the horizon, in the center of the image. This image was taken by the rover's navigation camera.

  20. The Twin Jet Nebula

    NASA Technical Reports Server (NTRS)

    1997-01-01

    M2-9 is a striking example of a 'butterfly' or a bipolar planetary nebula. Another more revealing name might be the 'Twin Jet Nebula.' If the nebula is sliced across the star, each side of it appears much like a pair of exhausts from jet engines. Indeed, because of the nebula's shape and the measured velocity of the gas, in excess of 200 miles per second, astronomers believe that the description as a super-super-sonic jet exhaust is quite apt. This is much the same process that takes place in a jet engine: The burning and expanding gases are deflected by the engine walls through a nozzle to form long, collimated jets of hot air at high speeds. M2-9 is 2,100 light-years away in the constellation Ophiucus. The observation was taken Aug. 2, 1997 by the Hubble telescope's Wide Field and Planetary Camera 2. In this image, neutral oxygen is shown in red, once-ionized nitrogen in green, and twice-ionized oxygen in blue.

  1. Researches on the Twin Prime Problem

    E-print Network

    Zhang Baoshan

    2014-05-13

    Twin prime number problem is mainly the structure of the twin prime numbers and whether there are infinitely many prime twins group. In this paper, by constructing a special cluster number set(see formula(2.3)in the paper), proves that the number of set number of the first n columns set the intersection of the minimum number of q is decision of the prime twins (q, q+2), and the minimum number of series is divergent(see Theorem 2).The main rezults are Theorem 2,Theorem 3 and Theorem 4.Prime twins so thoroughly proved there must be infinitely many groups of twin prime conjecture.

  2. Partnership for Healthy Mouths Healthy Lives

    MedlinePLUS

    ... our Partners     Every Child Deserves a Healthy Smile THE ISSUE Dental decay is the most ... the general population. OUR SOLUTION The Partnership for Healthy Mouths, Healthy Lives (PHMHL) is helping 73.6 ...

  3. Sister chromatid exchanges and cell division delays induced by diethylstilbestrol, estradiol, and estriol in human lymphocytes

    SciTech Connect

    Hill, A.; Wolff, S.

    1983-09-01

    It had been found previously that exposure of human lymphocytes in vitro to diethylstilbestrol (DES), a synthetic estrogen and known human carcinogen, led to the induction of sister chromatid exchangers. More sister chromatid exchanges were induced in cells from pregnant women than from men. To see if the effects of DES could be induced by other estrogens, lymphocytes from a man and a pregnant woman were treated in vitro with the natural estrogens estradiol and estriol. These did not induce sister chromatid exchanges.

  4. Vasospastic Angina in Identical Twins

    PubMed Central

    Yoshioka, Takayuki; Otsui, Kazunori; Suzuki, Atsushi; Ozawa, Toru; Iwata, Sachiyo; Takei, Asumi; Inoue, Nobutaka

    2015-01-01

    Patient: Male, 58 Final Diagnosis: Vasospastic angina Symptoms: Chest pain Medication: — Clinical Procedure: Medical treatment Specialty: Cardiology Objective: Rare disease Background: The clinical conditions of various diseases, including coronary artery disease, are determined by genetics and the environment. Previous investigations noted the significance of genetic mutations and polymorphisms in cases of coronary spasm. Case Report: We report on monozygotic identical twins who almost simultaneously presented with vasospastic angina. The 58-year-old younger twin was admitted to our hospital because of persistent chest pain. An electrocardiogram showed an inverted T wave in the left precordial leads. Coronary angiographies revealed a short left main trunk (LMT) and 50% stenosis at the proximal portion of the left anterior descending artery (LAD). Infusion of acetylcholine to his left coronary artery caused marked vasoconstriction associated with a sensation of chest oppression. Nitroglycerine completely reversed this response. Based on these findings, we diagnosed Twin A with vasospastic angina. At nearly the same time, his identical twin brother was diagnosed with vasospastic angina at another hospital. Comparison of both coronary angiograms indicated similar structure of coronary vessels, including short LMT and mild stenosis at the proximal portion of LAD. Conclusions: These 2 cases highlight the importance of genetic factors in the pathogenesis of vasospastic angina. It may be important for individuals to receive medical attention if their identical twin presents with vasospastic angina. PMID:26347942

  5. Plastic strain due to twinning in austenitic TWIP steels

    E-print Network

    Cambridge, University of

    Plastic strain due to twinning in austenitic TWIP steels B. Qin and H. K. D. H. Bhadeshia* Twinning induced plasticity steels are austenitic alloys in which mechanical twinning is a prominent deformation, Twinning, Twinning induced plasticity, Automobiles Introduction Mechanical twinning is a plastic

  6. 150. Photocopy of drawing (taken from Twin Falls Canal Company ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    150. Photocopy of drawing (taken from Twin Falls Canal Company Surveyor's Book #363, Page 42, entitled, 'Diversion Tunnels', located in Twin Falls Canal Company office, Twin Falls, Idaho). PLAN OF DIVERSION TUNNELS, MILNER DAM. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  7. Condensin II initiates sister chromatid resolution during S phase

    PubMed Central

    Ono, Takao; Yamashita, Daisuke

    2013-01-01

    Condensins I and II are multisubunit complexes that play essential yet distinct functions in chromosome condensation and segregation in mitosis. Unlike condensin I, condensin II localizes to the nucleus during interphase, but it remains poorly understood what functions condensin II might have before mitotic entry. Here, we report that condensin II changes its chromatin-binding property during S phase. Remarkably, advanced premature chromosome condensation (PCC) assays enabled us to visualize condensin II forming “sister axes” in replicated regions of chromosomes in S phase cells. Depletion of condensin II compromised PCC-driven sister chromatid resolution during S phase. Moreover, fluorescence in situ hybridization assays revealed that condensin II, but not condensin I, promotes disjoining duplicated chromosomal loci during S phase. Application of mild replicative stress partially impaired this process and further exacerbated phenotypes arising from condensin II depletion. Our results suggest that condensin II initiates structural reorganization of duplicated chromosomes during S phase to prepare for their proper condensation and segregation in mitosis. PMID:23401001

  8. Nike Twins Seven Seven: Nigerian Batik Artist.

    ERIC Educational Resources Information Center

    LaDuke, Betty

    1987-01-01

    Chronicles the personal and professional life of Nike Twins Seven Seven (born 1951), a Nigerian batik artist, and her husband, Twins Seven Seven, a musician-artist, both of whom have received international acclaim. (BJV)

  9. Maternal Hypomethylation of KvDMR in a Monozygotic Male Twin Pair Discordant for Beckwith-Wiedemann Syndrome

    PubMed Central

    Elalaoui, S.C.; Garin, I.; Sefiani, A.; Perez de Nanclares, G.

    2014-01-01

    Beckwith-Wiedemann syndrome (BWS; OMIM 130650) is a heterogeneous overgrowth syndrome characterized by visceromegaly, macroglossia, tumor predisposition, and other congenital abnormalities. BWS is usually associated with abnormalities of chromosome 11p15, including (epi)genetic changes, paternal disomy and point mutations. A number of identical twin pairs, mostly female, have been reported to be clinically discordant for BWS. Studies of monozygotic twins discordant for BWS provide more information about failure in the DNA methylation maintenance machinery during very early embryonic development. Here, we report a case of monozygotic male twins discordant for BWS phenotype. Methylation analysis of the 2 imprinted domains at 11p15.5 (H19DMR and KvDMR) was performed by methylation-specific MLPA and pyrosequencing of DNA extracted from peripheral blood and buccal swabs of both twins. Hypomethylation at KvDMR was identified in both cell types of the affected twin, whereas his healthy brother presented hypomethylation only in blood cells and a normal methylation profile in buccal swab. For diagnostic purposes, it is important to remember that twins can share fetal circulation and possibly share hematopoietic stem cells early in development; therefore, the affected and unaffected twins can share an epigenotype that will resemble partial hypomethylation. If a patient is a twin, it is valuable to obtain a sample from a tissue other than blood. PMID:24550765

  10. A Novel, Homozygous c.1502T>G (p.Val501Gly) Mutation in the Thyroid peroxidase Gene in Malaysian Sisters with Congenital Hypothyroidism and Multinodular Goiter

    PubMed Central

    Lee, Ching Chin; Harun, Fatimah; Jalaludin, Muhammad Yazid; Heh, Choon Han; Othman, Rozana; Mat Junit, Sarni

    2013-01-01

    Congenital hypothyroidism (CH) with multinodular goiter (MNG) is uncommonly seen in children. However, CH associated with goiter is often caused by defective Thyroid peroxidase (TPO) gene. In this study, we screened for mutation(s) in the TPO gene in two siblings with CH and MNG and their healthy family members. The two sisters, born to consanguineous parents, were diagnosed with CH during infancy and received treatment since then. They developed MNG during childhood despite adequate L-thyroxine replacement and negative thyroid antibody screening. PCR-amplification of all exons using flanking primers followed by DNA sequencing revealed that the two sisters were homozygous for a novel c.1502T>G mutation. The mutation is predicted to substitute valine for glycine at a highly conserved amino acid residue 501 (p.Val501Gly). Other healthy family members were either heterozygotes or mutation-free. The mutation was not detected in 50 healthy unrelated individuals. In silico analyses using PolyPhen-2 and SIFT predicted that the p.Val501Gly mutation is functionally “damaging.” Tertiary modeling showed structural alterations in the active site of the mutant TPO. In conclusion, a novel mutation, p.Val501Gly, in the TPO gene was detected expanding the mutation spectrum of TPO associated with CH and MNG. PMID:23737781

  11. Resolution of superimposed pre-eclampsia, and improvement in umbilical artery flow in a surviving twin after intrauterine demise of its co-twin.

    PubMed

    Narasimhulu, Deepa M; Karakash, Scarlett; Rankin, Linda; Minkoff, Howard

    2015-09-01

    Pre-eclampsia has a progressive clinical course, and is only cured by delivery of the placenta. We report a 30-year-old G1P0 with dichorionic twins, discordant growth and chronic hypertension who developed superimposed pre-eclampsia in her 21st week of gestation. After intrauterine demise of the severely growth-restricted twin, the superimposed pre-eclampsia resolved. The surviving twin initially had absent end diastolic flow, which resolved after the demise. A healthy 1935-g neonate with Apgar 9/9 was delivered at 34 weeks. Antenatal resolution of pre-eclampsia is extremely rare and resolution of superimposed pre-eclampsia has not, to our knowledge, been reported. PMID:26096469

  12. Speech and Language Delays in Identical Twins.

    ERIC Educational Resources Information Center

    Bentley, Pat

    Following a literature review on speech and language development of twins, case studies are presented of six sets of identical twins screened for entrance into kindergarten. Five sets of the twins and one boy from the sixth set failed to pass the screening test, particularly the speech and language section, and were referred for therapy to correct…

  13. On Teaching About Twins and Time

    ERIC Educational Resources Information Center

    Hewitt, Paul G.

    1973-01-01

    Discusses a four-step instructional presentation in which the twin on the earth is demonstrated older than the twin aboard a spaceship on the basis of the relativistic Doppler effect. Concludes that both twins can meet again at the same place in space at the expense of time. (CC)

  14. Twin Cities Metro Advanced Practice Center

    E-print Network

    Twin Cities Metro Advanced Practice Center Food Safety Self Inspection Checklist #12;Table-20 Vietnamese..............................21-22 #12;Food Safety Self Inspection Checklist Twin Cities Metro has expired. #12;Food Safety Self Inspection Checklist Twin Cities Metro Advanced Practice Center

  15. Healthy Water Healthy People Field Monitoring Guide

    ERIC Educational Resources Information Center

    Project WET Foundation, 2003

    2003-01-01

    This 100-page manual serves as a technical reference for the "Healthy Water, Healthy People Water Quality Educators Guide" and the "Healthy Water Healthy People Testing Kits". Yielding in-depth information about ten water quality parameters, it answers questions about water quality testing using technical overviews, data interpretation guidelines,…

  16. Coherent Twinning Phenomena: Towards Twinning Superlattices in III-V

    E-print Network

    Xiong, Qihua

    Vania 16802 Received July 21, 2006 ABSTRACT We report evidence in GaP and InP nanowires for a coherent the wire. This observation is indeed unexpected, as the vapor-liquid-solid growth conditions used in the growth zone. Future control of the twinning superlattice period should allow significant design

  17. NOTE: Increasing cardiac output and decreasing oxygenation sequence in pump twins of acardiac twin pregnancies

    NASA Astrophysics Data System (ADS)

    van Gemert, Martin J. C.; Umur, Asli; van den Wijngaard, Jeroen P. H. M.; Van Bavel, Ed; Vandenbussche, Frank P. H. A.; Nikkels, Peter G. J.

    2005-02-01

    An acardiac twin pregnancy is a rare but serious complication of monochorionic twinning and consists of an acardiac twin and a pump twin. The acardiac twin is a severely malformed fetus that lacks most organs, particularly a heart, but grows during pregnancy because it is perfused by the developmentally normal pump twin via a set of arterioarterial and venovenous placental anastomoses. Pump twins die intrauterine or neonatally in about 50% of the cases. Because the effects of an acardiac mass on the pump twin's development are incompletely known, methods for outcome prognosis are currently not available. We sought to derive simple relations for the pump twin's excess cardiac output and decreased oxygenation and to use available clinical cases for a preliminary test of the model. As a method, we used a theoretical flow model to represent the fetoplacental circulation of an acardiac twin pregnancy and estimated blood deoxygenation and reoxygenation following perfusion of the two bodies and placentas, respectively. The results show the pump twin's excess cardiac output and decrease of venous oxygen saturation to depend on the ratio of pump twin to acardiac twin umbilical blood flow, whose ratio can be measured by ultrasonography. The clinical cases show a decreasing umbilical flow ratio with gestation. In conclusion, prospective serial study is necessary to test whether measurement of umbilical flow ratios allows monitoring the pump twin's pathophysiologic development, possibly resulting in a guideline for prognosis of pump twin survival.

  18. Is That Me or My Twin? Lack of Self-Face Recognition Advantage in Identical Twins

    PubMed Central

    Martini, Matteo; Bufalari, Ilaria; Stazi, Maria Antonietta; Aglioti, Salvatore Maria

    2015-01-01

    Despite the increasing interest in twin studies and the stunning amount of research on face recognition, the ability of adult identical twins to discriminate their own faces from those of their co-twins has been scarcely investigated. One’s own face is the most distinctive feature of the bodily self, and people typically show a clear advantage in recognizing their own face even more than other very familiar identities. Given the very high level of resemblance of their faces, monozygotic twins represent a unique model for exploring self-face processing. Herein we examined the ability of monozygotic twins to distinguish their own face from the face of their co-twin and of a highly familiar individual. Results show that twins equally recognize their own face and their twin’s face. This lack of self-face advantage was negatively predicted by how much they felt physically similar to their co-twin and by their anxious or avoidant attachment style. We speculate that in monozygotic twins, the visual representation of the self-face overlaps with that of the co-twin. Thus, to distinguish the self from the co-twin, monozygotic twins have to rely much more than control participants on the multisensory integration processes upon which the sense of bodily self is based. Moreover, in keeping with the notion that attachment style influences perception of self and significant others, we propose that the observed self/co-twin confusion may depend upon insecure attachment. PMID:25853249

  19. Four twins for a paradox: on "sensitive" twins and the biological counterpart of the "twin paradox".

    PubMed

    Ascioti, Fortunato A

    2009-03-01

    Monozygotic twin (MZT) epigenetic development, i.e., aging, diverges largely in time despite the initially very small genetic differences between MZTs. This fact is interpreted as a "sensitivity to initial conditions" phenomenon, a common property of either deterministic or stochastic chaotic systems. Some of the biotheoretical implications stemming from this empirical observation are briefly discussed here, while an actual measure of MZT epigenetic time divergence is given through an estimate of the (Stochastic) Lyapunov exponents (LEs) (i.e., the rate of exponential time divergence). These results suggest a reconsideration of the Langevin-Einstein thought experiment known as the "twin paradox." At least four twins are necessary in order to take into account the inertially independent divergent aging described here. Alternatively, LE estimates, like those given here, should be used. Finally suggested in the actual special-relativity experiments is the replacement of clocks with some nonlinear (chaotic) forced oscillator. PMID:19334992

  20. Genetic Influences on Alcohol Use Behaviors Have Diverging Developmental Trajectories: A Prospective Study among Male and Female Twins

    PubMed Central

    Meyers, Jacquelyn L.; Salvatore, Jessica E.; Vuoksimaa, Eero; Korhonen, Tellervo; Pulkkinen, Lea; Rose, Richard J.; Kaprio, Jaakko; Dick, Danielle M.

    2014-01-01

    Background Both alcohol-specific genetic factors and genetic factors related to externalizing behavior influence problematic alcohol use. Little is known, however, about the etiologic role of these two components of genetic risk on alcohol-related behaviors across development. Prior studies conducted in a male cohort of twins suggest that externalizing genetic factors are important for predicting heavy alcohol use in adolescence, whereas alcohol-specific genetic factors increase in importance during the transition to adulthood. In this report, we studied twin brothers and sisters and brother-sister twin pairs to examine such developmental trajectories and investigate whether sex and co-twin sex effects modify these genetic influences. Methods We used prospective, longitudinal twin data collected between ages 12 and 22 within the population-based FinnTwin12 cohort study (analytic n=1,864). Our dependent measures of alcohol use behaviors included alcohol initiation (age 12), intoxication frequency (ages 14 and 17), and alcohol dependence criteria (age 22). Each individual’s genetic risk for alcohol use disorders (AUD-GR) was indexed by his/her parents’ and co-twin’s DSM-IV Alcohol Dependence (AD) criterion counts. Likewise, each individual’s genetic risk for externalizing disorders (EXT-GR) was indexed with a composite measure of parents’ and co-twin’s DSM-IV Conduct Disorder and Antisocial Personality Disorder criterion counts. Results EXT-GR was most strongly related to alcohol use behaviors during adolescence while AUD-GR was most strongly related to alcohol problems in young adulthood. Further, sex of the twin and sex of the co-twin significantly moderated the associations between genetic risk and alcohol use behaviors across development: AUD-GR influenced early adolescent alcohol use behaviors in females more than in males, and EXT-GR influenced age 22 AD more in males than in females. In addition, the associations of AUD-GR and EXT-GR with intoxication frequency were greater among 14 and 17 year old females with twin brothers. Conclusions We found divergent developmental trajectories for alcohol-specific and externalizing behavior-related genetic influences on alcohol use behaviors; in early adolescence, genetic influences on alcohol use behaviors are largely non-specific, and later in adolescence and young adulthood, alcohol specific genetic influences on alcohol use are more influential. Importantly, within these overall trajectories, several interesting sex differences emerged. We found that the relationship between genetic risk and problematic drinking across development is moderated by the individual’s sex and his/her co-twin’s sex. AUD-GR influenced adolescent alcohol outcomes in females more than in males and by age 22, EXT-GR influenced AD criteria more for males than females. In addition, the association between genetic risk and intoxication frequency was greater among 14 and 17 year old females with male co-twins. PMID:25421521

  1. A Powerful Twin Arrives

    NASA Astrophysics Data System (ADS)

    1999-11-01

    First Images from FORS2 at VLT KUEYEN on Paranal The first, major astronomical instrument to be installed at the ESO Very Large Telescope (VLT) was FORS1 ( FO cal R educer and S pectrograph) in September 1998. Immediately after being attached to the Cassegrain focus of the first 8.2-m Unit Telescope, ANTU , it produced a series of spectacular images, cf. ESO PR 14/98. Many important observations have since been made with this outstanding facility. Now FORS2 , its powerful twin, has been installed at the second VLT Unit Telescope, KUEYEN . It is the fourth major instrument at the VLT after FORS1 , ISAAC and UVES.. The FORS2 Commissioning Team that is busy installing and testing this large and complex instrument reports that "First Light" was successfully achieved already on October 29, 1999, only two days after FORS2 was first mounted at the Cassegrain focus. Since then, various observation modes have been carefully tested, including normal and high-resolution imaging, echelle and multi-object spectroscopy, as well as fast photometry with millisecond time resolution. A number of fine images were obtained during this work, some of which are made available with the present Press Release. The FORS instruments ESO PR Photo 40a/99 ESO PR Photo 40a/99 [Preview - JPEG: 400 x 345 pix - 203k] [Normal - JPEG: 800 x 689 pix - 563kb] [Full-Res - JPEG: 1280 x 1103 pix - 666kb] Caption to PR Photo 40a/99: This digital photo shows the twin instruments, FORS2 at KUEYEN (in the foreground) and FORS1 at ANTU, seen in the background through the open ventilation doors in the two telescope enclosures. Although they look alike, the two instruments have specific functions, as described in the text. FORS1 and FORS2 are the products of one of the most thorough and advanced technological studies ever made of a ground-based astronomical instrument. They have been specifically designed to investigate the faintest and most remote objects in the universe. They are "multi-mode instruments" that may be used in several different observation modes. FORS2 is largely identical to FORS1 , but there are a number of important differences. For example, it contains a Mask Exchange Unit (MXU) for laser-cut star-plates [1] that may be inserted at the focus, allowing a large number of spectra of different objects, in practice up to about 70, to be taken simultaneously. Highly sophisticated software assigns slits to individual objects in an optimal way, ensuring a great degree of observing efficiency. Instead of the polarimetry optics found in FORS1 , FORS2 has new grisms that allow the use of higher spectral resolutions. The FORS project was carried out under ESO contract by a consortium of three German astronomical institutes, the Heidelberg State Observatory and the University Observatories of Göttingen and Munich. The participating institutes have invested a total of about 180 man-years of work in this unique programme. The photos below demonstrate some of the impressive possibilities with this new instrument. They are based on observations with the FORS2 standard resolution collimator (field size 6.8 x 6.8 armin = 2048 x 2048 pixels; 1 pixel = 0.20 arcsec). In addition, observations of the Crab pulsar demonstrate a new observing mode, high-speed photometry. Protostar HH-34 in Orion ESO PR Photo 40b/99 ESO PR Photo 40b/99 [Preview - JPEG: 400 x 444 pix - 220kb] [Normal - JPEG: 800 x 887 pix - 806kb] [Full-Res - JPEG: 2000 x 2217 pix - 3.6Mb] The Area around HH-34 in Orion ESO PR Photo 40c/99 ESO PR Photo 40c/99 [Preview - JPEG: 400 x 494 pix - 262kb] [Full-Res - JPEG: 802 x 991 pix - 760 kb] The HH-34 Superjet in Orion (centre) PR Photo 40b/99 shows a three-colour composite of the young object Herbig-Haro 34 (HH-34) , now in the protostar stage of evolution. It is based on CCD frames obtained with the FORS2 instrument in imaging mode, on November 2 and 6, 1999. This object has a remarkable, very complicated appearance that includes two opposite jets that ram into the surrounding interstellar matter. This structure is produced by a machine-gu

  2. Evolutionary Applications (in press, December 2008) Genomic Sister-Disorders of Neurodevelopment

    E-print Network

    Crespi, Bernard J.

    1 Evolutionary Applications (in press, December 2008) Genomic Sister-Disorders of Neurodevelopment, Bath BA2 7AY United Kingdom sd236@bath.ac.uk #12;2 Abstract Genomic sister-disorders are defined here as diseases mediated by duplications versus deletions of the same region. Such disorders can provide unique

  3. Brothers and Sisters of Children with Disabilities: An Annotated Bibliography. Families as Allies Project.

    ERIC Educational Resources Information Center

    Smieja, Linda L.; And Others

    This annotated bibliography provides a comprehensive review of literature focusing on brothers and sisters of children with emotional disorders. Some material addressing brothers and sisters of children who have physical, mental, or developmental disabilities is also included. The bibliography lists approximately 80 references covering a 10-year…

  4. Support Groups for Sisters and Brothers of Children with Intellectual and Developmental Disabilities

    ERIC Educational Resources Information Center

    Scelles, Regine; Bouteyre, Evelyne; Dayan, Clemence; Picon, Ingrid

    2012-01-01

    This prospective study aimed at shedding some light on the functioning of French support groups for brothers and sisters of children with disabilities. Semi-structured interviews were conducted with the sisters, brothers and parents of children with disabilities along with care professionals. Focus groups were carried out with healthcare…

  5. 40 CFR 79.65 - In vivo sister chromatid exchange assay.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... references should be consulted. (1) 40 CFR 798.5915, In vivo Sister Chromatid Exchange Assay. (2) Kato, H...) assay detects the ability of a chemical to enhance the exchange of DNA between two sister chromatids of... ligation of at least two DNA helices. (c) Test method—(1) Principle of the test method. (i) Groups...

  6. 40 CFR 79.65 - In vivo sister chromatid exchange assay.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... references should be consulted. (1) 40 CFR 798.5915, In vivo Sister Chromatid Exchange Assay. (2) Kato, H...) assay detects the ability of a chemical to enhance the exchange of DNA between two sister chromatids of... ligation of at least two DNA helices. (c) Test method—(1) Principle of the test method. (i) Groups...

  7. 40 CFR 79.65 - In vivo sister chromatid exchange assay.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... references should be consulted. (1) 40 CFR 798.5915, In vivo Sister Chromatid Exchange Assay. (2) Kato, H...) assay detects the ability of a chemical to enhance the exchange of DNA between two sister chromatids of... ligation of at least two DNA helices. (c) Test method—(1) Principle of the test method. (i) Groups...

  8. 40 CFR 79.65 - In vivo sister chromatid exchange assay.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... references should be consulted. (1) 40 CFR 798.5915, In vivo Sister Chromatid Exchange Assay. (2) Kato, H...) assay detects the ability of a chemical to enhance the exchange of DNA between two sister chromatids of... ligation of at least two DNA helices. (c) Test method—(1) Principle of the test method. (i) Groups...

  9. The MCM-Binding Protein ETG1 Aids Sister Chromatid Cohesion Required for Postreplicative Homologous

    E-print Network

    Gent, Universiteit

    The MCM-Binding Protein ETG1 Aids Sister Chromatid Cohesion Required for Postreplicative Homologous in a stringent late G2 cell cycle arrest. This arrest correlated with a partial loss of sister chromatid cohesion. The lack-of-cohesion phenotype was intensified in plants without functional CTF18, a replication fork

  10. Defective sister-chromatid cohesion, aneuploidy and cancer predisposition in a mouse model of

    E-print Network

    Defective sister-chromatid cohesion, aneuploidy and cancer predisposition in a mouse model of type-chromatid cohesion, and suggest that the chromosomal instability may be the underlying cause of cancer predisposition-chromatids is required (5,8). Therefore, sister-chromatid cohesion has an essential role in establishing this bipolar

  11. Twin Peaks (B/W)

    NASA Technical Reports Server (NTRS)

    1997-01-01

    The Twin Peaks are modest-size hills to the southwest of the Mars Pathfinder landing site. They were discovered on the first panoramas taken by the IMP camera on the 4th of July, 1997, and subsequently identified in Viking Orbiter images taken over 20 years ago. The peaks are approximately 30-35 meters (-100 feet) tall. North Twin is approximately 860 meters (2800 feet) from the lander, and South Twin is about a kilometer away (3300 feet). The scene includes bouldery ridges and swales or 'hummocks' of flood debris that range from a few tens of meters away from the lander to the distance of the South Twin Peak. The large rock at the right edge of the scene is nicknamed 'Hippo'. This rock is about a meter (3 feet) across and 25 meters (80 feet) distant.

    Mars Pathfinder is the second in NASA's Discovery program of low-cost spacecraft with highly focused science goals. The Jet Propulsion Laboratory, Pasadena, CA, developed and manages the Mars Pathfinder mission for NASA's Office of Space Science, Washington, D.C. JPL is a division of the California Institute of Technology (Caltech). The IMP was developed by the University of Arizona Lunar and Planetary Laboratory under contract to JPL. Peter Smith is the Principal Investigator.

  12. Bold vision: Catholic sisters and the creation of American hospitals.

    PubMed

    Levin, Peter J

    2011-06-01

    American hospitals were started by religious, ethnic and community groups to serve local health care needs. Immigration into the eastern cities and the constant movement west of the frontier required the creation of educational and service facilities to serve these populations and localities. In the nineteenth century, Catholic sisters went all across the country establishing schools and hospitals. They were motivated to care for the sick, establish charitable institutions and spread their religious beliefs. Their impact on the development of the American health system was enormous. They also supported the importance of nursing for the provision of scientifically based medical care and created schools of nursing. Their historical record as founders, builders, financiers and managers of hospitals is unmatched by any other group between 1850 and 1950. And, this was accomplished at a time when women played no similar leadership and institutional ownership role elsewhere in society. PMID:21452027

  13. Telomere sister chromatid exchange in telomerase deficient murine cells

    SciTech Connect

    Wang, Yisong; Giannone, Richard J; Liu, Yie

    2005-01-01

    We have recently demonstrated that several types of genomic rearrangements (i.e., telomere sister chromatid exchange (T-SCE), genomic-SCE, or end-to-end fusions) were more often detected in long-term cultured murine telomerase deficient embryonic stem (ES) cells than in freshly prepared murine splenocytes, even through they possessed similar frequencies of critically short telomeres. The high rate of genomic rearrangements in telomerase deficient ES cells, when compared to murine splenocytes, may reflect the cultured cells' gained ability to protect chromosome ends with eroded telomeres allowing them to escape 'end crisis'. However, the possibility that ES cells were more permissive to genomic rearrangements than other cell types or that differences in the microenvironment or genetic background of the animals might consequentially determine the rate of T-SCEs or other genomic rearrangements at critically short telomeres could not be ruled out.

  14. Molecular analysis of the gut microbiota of identical twins with Crohn's disease

    SciTech Connect

    Jansson, Janet; Dicksved, Johan; Halfvarson, Jonas; Rosenquist, Magnus; Jarnerot, Gunnar; Tysk, Curt; Apajalahti, Juha; Engstrand, Lars; Jansson, Janet K.

    2008-03-14

    Increasing evidence suggests that a combination of host genetics and the composition of the gut microbiota are important for development of Crohn's disease (CD). Our aim was to study identical twins with CD to determine microbial factors independently of host genetics. Fecal samples were studied from 10 monozygotic twin pairs with CD (discordant n=6, concordant n=4) and 8 healthy twin pairs. DNA was extracted, 16S rRNA genes were PCR amplified and T-RFLP fingerprints generated using general bacterial and Bacteroides group specific primers. The microbial communities were also profiled based on their % G+C contents. Bacteroides 16S rRNA genes were cloned and sequenced from a subset of the samples. The bacterial diversity in each sample and similarity indices between samples were estimated based on the T-RFLP data using a combination of statistical approaches. Healthy individuals had a significantly higher bacterial diversity compared to individuals with CD. The fecal microbial communities were more similar between healthy twins than between twins with CD, especially when these were discordant for the disease. The microbial community profiles of individuals with ileal CD were significantly different from healthy individuals and those with colonic CD. Also, CD individuals had a lower relative abundance of B. uniformis and higher relative abundances of B. ovatus and B. vulgatus. Our results suggest that genetics and/or environmental exposure during childhood in part determine the gut microbial composition. However, CD is associated with dramatic changes in the gut microbiota and this was particularly evident for individuals with ileal CD.

  15. Genetic and physical analyses of sister chromatid exchange in yeast meiosis.

    PubMed Central

    Sun, H; Dawson, D; Szostak, J W

    1991-01-01

    We have used nonessential circular minichromosomes to monitor sister chromatid exchange during yeast meiosis. Genetic analysis shows that a 64-kb circular minichromosome undergoes sister chromatid exchange during 40% of meioses. This frequency is not reduced by the presence of a homologous linear minichromosome. Furthermore, sister chromatid exchange can be stimulated by the presence of a 12-kb ARG4 DNA fragment, which contains initiation sites for meiotic gene conversion. Using physical analysis, we have directly identified a product of sister chromatid exchange: a head-to-tail dimer form of a circular minichromosome. This dimer form is absent in a rad50S mutant strain, which is deficient in processing of the ends of meiosis-specific double-stranded breaks into single-stranded DNA tails. Our studies suggest that meiotic sister chromatid exchange is stimulated by the same mechanism as meiotic homolog exchange. Images PMID:1944292

  16. Sgo1 is required for co-segregation of sister chromatids during achiasmate meiosis I

    PubMed Central

    Dudas, Andrej; Ahmad, Shazia

    2011-01-01

    The reduction of chromosome number during meiosis is achieved by two successive rounds of chromosome segregation, called meiosis I and meiosis II. While meiosis II is similar to mitosis in that sister kinetochores are bi-oriented and segregate to opposite poles, recombined homologous chromosomes segregate during the first meiotic division. Formation of chiasmata, mono-orientation of sister kinetochores and protection of centromeric cohesion are three major features of meiosis I chromosomes which ensure the reductional nature of chromosome segregation. Here we show that sister chromatids frequently segregate to opposite poles during meiosis I in fission yeast cells that lack both chiasmata and the protector of centromeric cohesion Sgo1. Our data are consistent with the notion that sister kinetochores are frequently bi-oriented in the absence of chiasmata and that Sgo1 prevents equational segregation of sister chromatids during achiasmate meiosis I. PMID:21330786

  17. Having a Brother or Sister with Down Syndrome: Perspectives from Siblings

    PubMed Central

    Skotko, Brian G.; Levine, Susan P.; Goldstein, Richard

    2012-01-01

    This study asks brothers and sisters about their feelings and perceptions toward their sibling with Down syndrome. We analyzed valid and reliable surveys from 822 brothers and sisters whose families were on the mailing lists of six non-profit Down syndrome organizations around the country. More than 96% of brothers/sisters that responded to the survey indicated that they had affection toward their sibling with Down syndrome; and 94% of older siblings expressed feelings of pride. Less than 10% felt embarrassed, and less than 5% expressed a desire to trade their sibling in for another brother or sister without Down syndrome. Among older siblings, 88% felt that they were better people because of their siblings with Down syndrome, and more than 90% plan to remain involved in their sibling’s lives as they become adults. The vast majority of brothers and sisters describe their relationship with their sibling with Down syndrome as positive and enriching. PMID:21910244

  18. Cohort Profile: Swedish Twin Study on Prediction and Prevention of Asthma (STOPPA).

    PubMed

    Almqvist, Catarina; Örtqvist, Anne K; Ullemar, Vilhelmina; Lundholm, Cecilia; Lichtenstein, Paul; Magnusson, Patrik K E

    2015-06-01

    Asthma is a common childhood disease and several risk factors have been identified; however, the impact of genes and environment is not fully understood. The aim of the Swedish Twin study On Prediction and Prevention of Asthma (STOPPA) is to identify environmental (birth characteristics and early life) and genetic (including epigenetic) factors as determinants for asthmatic disease. Based on the Child and Adolescent Twin Study in Sweden (CATSS) (parental interview at 9 or 12 years, N ~23,900) and an asthma and/or wheezing algorithm, we identified a sample of monozygotic (MZ) and dizygotic (DZ) same-sexed twin pairs. The twin pairs were classified as asthma concordant (ACC), asthma discordant (ADC) and healthy concordant (HCC). A sample of 9- to 14-year-old twins and their parents were invited to participate in a clinical examination. Background characteristics were collected in questionnaires and obtained from the National Health Registers. A clinical examination was performed to test lung function and capacity (spirometry with reversibility test and exhaled nitric oxide) and collect blood (serology and DNA), urine (metabolites), feces (microbiota), and saliva (cortisol). In total, 376 twin pairs (752 individual twins) completed the study, response rate 52%. All participating twins answered the questionnaire and >90% participated in lung function testing, blood-, and saliva sampling. This article describes the design, recruitment, data collection, measures, and background characteristics, as well as ongoing and planned analyses in STOPPA. Potential gains of the study include the identification of biomarkers, the emergence of candidates for drug development, and new leads for prevention of asthma and allergic disease. PMID:25900604

  19. Dynamics of twinning dislocations in Tantalum

    NASA Astrophysics Data System (ADS)

    Sandoval, Luis; Surh, Michael; Chernov, Alexander; Richards, David

    2012-02-01

    Twinning is one of the major deformation modes of plastic deformation in crystals, being particularly important in systems under extreme conditions of low temperature or high strain rates. Despite decades of work, the nucleation and growth mechanisms of twining are still poorly understood, especially in bcc metals. Nucleation of twinning dislocations loops on the coherent twin boundary has been considered a principal mechanism of growth of deformation twins. We have used molecular dynamics simulation to study the behavior of twinning dislocations in Tantalum, in particular the dependence of dislocation velocities on shear stress and temperature. The dynamics of edge and screw twinning dislocations is isolated and analyzed. Finally we show how kinetic parameters extracted from these simulations help inform a multiscale strength model for Tantalum that includes both twinning and slip as deformation mechanisms in the regime of high strain rates.

  20. The geography and ecology of plant speciation: range overlap and niche divergence in sister species

    PubMed Central

    Anacker, Brian L.; Strauss, Sharon Y.

    2014-01-01

    A goal of evolutionary biology is to understand the roles of geography and ecology in speciation. The recent shared ancestry of sister species can leave a major imprint on their geographical and ecological attributes, possibly revealing processes involved in speciation. We examined how ecological similarity, range overlap and range asymmetry are related to time since divergence of 71 sister species pairs in the California Floristic Province (CFP). We found that plants exhibit strikingly different age-range correlation patterns from those found for animals; the latter broadly support allopatric speciation as the primary mode of speciation. By contrast, plant sisters in the CFP were sympatric in 80% of cases and range sizes of sisters differed by a mean of 10-fold. Range overlap and range asymmetry were greatest in younger sisters. These results suggest that speciation mechanisms broadly grouped under ‘budding’ speciation, in which a larger ranged progenitor gives rise to a smaller ranged derivative species, are probably common. The ecological and reproductive similarity of sisters was significantly greater than that of sister–non-sister congeners for every trait assessed. However, shifts in at least one trait were present in 93% of the sister pairs; habitat and soil shifts were especially common. Ecological divergence did not increase with range overlap contrary to expectations under character displacement in sympatry. Our results suggest that vicariant speciation is more ubiquitous in animals than plants, perhaps owing to the sensitivity of plants to fine-scale environmental heterogeneity. Despite high levels of range overlap, ecological shifts in the process of budding speciation may result in low rates of fine-scale spatial co-occurrence. These results have implications for ecological studies of trait evolution and community assembly; despite high levels of sympatry, sister taxa and potentially other close relatives, may be missing from local communities. PMID:24452025

  1. Monozygotic Twins Discordant for Neurofibromatosis 1

    PubMed Central

    Kaplan, Lee; Foster, Rosemary; Shen, Yiping; Parry, Dilys M.; McMaster, Mary L.; O’Leary, Melanie Collins; Gusella, James F.

    2009-01-01

    We present monozygotic twins discordant for the autosomal dominant disorder neurofibromatosis type 1 (NF1). The affected twin was diagnosed with NF1 at age 12, based upon accepted clinical criteria for the disorder. Both twins were re-examined at ages 35 and 57, at which times the unaffected twin continued to show no clinical manifestations of NF1. Short tandem repeat marker (STR) genotyping at 10 loci on chromosome 17 and 10 additional loci dispersed across the genome revealed identical genotypes for the twins, confirming their monozygosity. The affected twin has three children, two of whom also have NF1, while the unaffected twin has two children, both unaffected. Using lymphoblastoid, fibroblast, and buccal cell samples collected from both twins and from other family members in three generations, we discovered a pathogenic nonsense mutation in exon 40 of the NF1 gene. This mutation was found in all cell samples from the affected twin and her affected daughter, and in lymphoblastoid and buccal cells but not fibroblasts from the unaffected twin. We also found a novel non-synonymous change in exon 16 of the NF1 gene that was transmitted from the unaffected mother to both twins and co-segregated with the pathogenic mutation in the ensuing generation. All cells from the twins were heterozygous for this apparent exon 16 polymorphism and for single nucleotide polymorphisms (SNPs) within 2.5kb flanking the site of the exon 40 nonsense mutation. This suggests that the NF1 gene of the unaffected twin differed in the respective lymphoblastoid cells and fibroblasts only at the mutation site itself, making post-zygotic mutation leading to mosaicism the most likely mechanism of phenotypic discordance. Although the unaffected twin is a mosaic, the distribution of the mutant allele among different cells and tissues appears to be insufficient to cause overt clinical manifestations of NF1. PMID:20186797

  2. Why the Healing Gods Are Twins

    PubMed Central

    Hankoff, Leon D.

    1977-01-01

    The association of twins with health-giving powers is widespread in mythology, folklore, and religion. The Ashvins of the Rig-Veda, the classical Dioscuri, and the early Christian saints Cosmos and Damian are among the many examples of twins divinely empowered in the area of health and fertility. A characteristic set of attributes of twins recurs in different mythologies of wide distribution. In addition to healing, divine twins are often empowered with the ability to revive the dead, increase the fertility of man, animals, and crops, influence the weather, predict the future, and insure victory in battle. In some traditional societies these special attributes are thought to extend to all of the twins and their parents in the tribe. Ancient and primitive societies supposed that the birth of twins was associated with divine influence, the mother having been visited or otherwise affected by supernatural powers. A frequent explanation was that twins were the result of superfetation, a divine impregnation occurring along with that by the lawful husband. The specific powers of divine twins appear to be a reflection of the particular form of origin of twins through divine interference with the fertilization process. The twins thus share some of the powers of the divine parent, particularly those pertaining to fertility. Their dual paternity and its inherent competition is related to their martial interests as well as their ability to resolve ambivalent or ambiguous situations and predict outcomes. PMID:560764

  3. Pathology of twin placentas with special attention to monochorionic twin placentas.

    PubMed

    Nikkels, P G J; Hack, K E A; van Gemert, M J C

    2008-12-01

    The risk of perinatal morbidity and mortality in twins is 3-7 times higher than in singletons. In comparison to dichorionic twins, monochorionic twins are at increased risk for perinatal mortality and serious morbidity. In both type of twins growth discordance can occur. Discordant growth of dichorionic twins could be due to differences in placental mass or differences in placental parenchymal lesions, whereas birth weight discordancy in monochorionic twins is caused by placental vascular anastomoses. In this review the different types of complications (acardiac twins, acute and chronic twin-twin transfusion syndrome) due to different combinations of vascular anastomoses are discussed in relation to a computer model developed to gain more insight into the development of the twin-twin transfusion syndrome. The angioarchitecture of 395 monochorionic twin placentas was studied. Mortality was highest in the absence of an arterio-arterial anastomosis (42%) and lowest in the presence of an arterio-arterial anastomosis (15%). If mortality occurred, pregnancies with double mortality usually had an arterio-arterial anastomosis. If pregnancies were complicated by one death, a veno-venous anastomosis is more likely to be present. In conclusion, monochorionic twin pregnancies are a high risk pregnancy with a high chance of both mortality and morbidity; placental characteristics are a major contributor to adverse outcome in these pregnancies. PMID:18794196

  4. Chromosome-specific non-random sister chromatid segregation during stem cell division

    PubMed Central

    Yadlapalli, Swathi; Yamashita, Yukiko M.

    2013-01-01

    Adult stem cells undergo asymmetric cell division to self-renew and give rise to differentiated cells that comprise mature tissue1. Sister chromatids may be distinguished and segregated non-randomly in asymmetrically dividing stem cells2, although the underlying mechanism and the purpose it may serve remain elusive. We developed the CO-FISH (chromosome orientation fluorescence in situ hybridization) technique3 with single-chromosome resolution and show that sister chromatids of X and Y chromosomes, but not autosomes, are segregated non-randomly during asymmetric divisions of Drosophila male germline stem cells (GSCs). This provides the first direct evidence that two sister chromatids containing identical genetic information can be distinguished and segregated non-randomly during asymmetric stem cell divisions. We further show that the centrosome, SUN-KASH nuclear envelope proteins, and Dnmt2 are required for non-random sister chromatid segregation. Our data suggest that the information on X and Y chromosomes that enables non-random segregation is primed during gametogenesis in the parents. Moreover, we show that sister chromatid segregation is randomized in GSC overproliferation and dedifferentiated GSCs. We propose that non-random sister chromatid segregation may serve to transmit distinct information carried on two sister chromatids to the daughters of asymmetrically dividing stem cells. PMID:23644460

  5. Women in-between' (Strathern, 1995): the ambiguous position of the sister tutor, 1918-1960.

    PubMed

    Brooks, Jane

    2007-02-01

    The purpose of this article is to explore the ambiguous position of sister tutors, within the nursing and hospital hierarchy between 1918 and 1960. The function of the sister tutor was to train the probationers (student nurses). However, I will argue that the students' education was to come second to the service needs of the hospital, the authority of the matron and desire of the medical profession to maintain control over the nursing curriculum and nursing practice. Therefore sister tutors were caught 'in-between' several opposing forces which together militated against the individual sister tutor's work and the ability of the nursing profession to recruit adequate numbers of senior nurses into the classroom. The recruitment issue was further hampered by the widespread knowledge that much of the sister tutor's work was not student education at all, but organising lectures by medical staff and marking students' notes. In order to gauge the 'official' attitudes to the sister tutors and also the experiences of those who either worked as sister tutors or were taught by them, I used both archival and oral evidence in the research for this article. Pseudonyms have been used throughout for the oral history respondents. PMID:16766093

  6. Intra-Monozygotic Twin Pair Discordance and Longitudinal Variation of Whole-Genome Scale DNA Methylation in Adults

    PubMed Central

    Zhang, Su-Hua; Chen, Jinzhong; Lu, Daru; Shen, Min; Li, Chengtao

    2015-01-01

    Monozygotic twins share identical genomic DNA and are indistinguishable using conventional genetic markers. Increasing evidence indicates that monozygotic twins are epigenetically distinct, suggesting that a comparison between DNA methylation patterns might be useful to approach this forensic problem. However, the extent of epigenetic discordance between healthy adult monozygotic twins and the stability of CpG loci within the same individual over a short time span at the whole-genome scale are not well understood. Here, we used Infinium HumanMethylation450 Beadchips to compare DNA methylation profiles using blood collected from 10 pairs of monozygotic twins and 8 individuals sampled at 0, 3, 6, and 9 months. Using an effective and unbiased method for calling differentially methylated (DM) CpG sites, we showed that 0.087%–1.530% of the CpG sites exhibit differential methylation in monozygotic twin pairs. We further demonstrated that, on whole-genome level, there has been no significant epigenetic drift within the same individuals for up to 9 months, including one monozygotic twin pair. However, we did identify a subset of CpG sites that vary in DNA methylation over the 9-month period. The magnitude of the intra-pair or longitudinal methylation discordance of the CpG sites inside the CpG islands is greater than those outside the CpG islands. The CpG sites located on shores appear to be more suitable for distinguishing between MZ twins. PMID:26248206

  7. Intra-Monozygotic Twin Pair Discordance and Longitudinal Variation of Whole-Genome Scale DNA Methylation in Adults.

    PubMed

    Zhang, Na; Zhao, Shumin; Zhang, Su-Hua; Chen, Jinzhong; Lu, Daru; Shen, Min; Li, Chengtao

    2015-01-01

    Monozygotic twins share identical genomic DNA and are indistinguishable using conventional genetic markers. Increasing evidence indicates that monozygotic twins are epigenetically distinct, suggesting that a comparison between DNA methylation patterns might be useful to approach this forensic problem. However, the extent of epigenetic discordance between healthy adult monozygotic twins and the stability of CpG loci within the same individual over a short time span at the whole-genome scale are not well understood. Here, we used Infinium HumanMethylation450 Beadchips to compare DNA methylation profiles using blood collected from 10 pairs of monozygotic twins and 8 individuals sampled at 0, 3, 6, and 9 months. Using an effective and unbiased method for calling differentially methylated (DM) CpG sites, we showed that 0.087%-1.530% of the CpG sites exhibit differential methylation in monozygotic twin pairs. We further demonstrated that, on whole-genome level, there has been no significant epigenetic drift within the same individuals for up to 9 months, including one monozygotic twin pair. However, we did identify a subset of CpG sites that vary in DNA methylation over the 9-month period. The magnitude of the intra-pair or longitudinal methylation discordance of the CpG sites inside the CpG islands is greater than those outside the CpG islands. The CpG sites located on shores appear to be more suitable for distinguishing between MZ twins. PMID:26248206

  8. 158. Photocopy of transit book (taken from Twin Falls Canal ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    158. Photocopy of transit book (taken from Twin Falls Canal Company Transit Book #404T, Page 3, #46, Division One). START OF MAIN CANAL SURVEY, TWIN FALLS COUNTY, MILNER, IDAHO. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  9. 154. Photocopy of transit book (taken from Twin Falls Canal ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    154. Photocopy of transit book (taken from Twin Falls Canal Company Surveyor's Transit Book #405T, Page 2, #46 Division One). STATEMENT OF SIGHT-SETTING FOR 1903 SURVEY TO ALIGN SOUTH SIDE CANAL, TWIN FALLS COUNTY, MILNER, IDAHO. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  10. 155. Photocopy of transit book (taken from Twin Falls Canal ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    155. Photocopy of transit book (taken from Twin Falls Canal Company Surveyor's Transit Book #405T, Page 1, #46 Division One). STATEMENT RE: SURVEY ALIGNMENT 3/03, TWIN FALLS COUNTY, MILNER, IDAHO. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  11. 152. Photocopy of drawing (taken from Twin Falls Canal Company ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    152. Photocopy of drawing (taken from Twin Falls Canal Company Surveyor's Transit Book #363, Page 1). 1912 CONDITION REPORT OF MILNER DAM AREA, TWIN FALLS COUNTY, MILNER, IDAHO. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  12. 153. Photocopy of drawing (taken from Twin Falls Canal Company ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    153. Photocopy of drawing (taken from Twin Falls Canal Company Field Book #360, Page 74, entitled, 'Clay-Seam Cut-Off.' Cross-Reference: ID-15-157). MILNER DAM SURVEY, TWIN FALLS COUNTY, MILNER, IDAHO. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  13. 151. Photocopy of drawing (taken from Twin Falls Canal Company ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    151. Photocopy of drawing (taken from Twin Falls Canal Company Surveyor's Transit Book #363, Page 20). SURVEY PRINT SHOWING POINT SPILLWAY AND FIELD NOTES, TWIN FALLS COUNTY NORTHWEST OF MURTAUGH, IDAHO. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  14. 1. GENERAL VIEW OF THE LOWER END OF TWIN LAKES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. GENERAL VIEW OF THE LOWER END OF TWIN LAKES SHOWING THE HISTORIC OUTLET WORKS AT THE EDGE OF THE WATER NEAR CENTER OF THE PHOTO WITH THE NEW TWIN LAKES DAM JUST BEHIND. VIEW LOOKING SOUTHEAST. - Twin Lakes Dam & Outlet Works, Beneath Twin Lakes Reservoir, T11S, R80W, S22, Twin Lakes, Lake County, CO

  15. Healthy Eating for Preschoolers

    MedlinePLUS

    Healthy Eating Get your child on the path to healthy eating. Focus on the meal and each other. Your ... child’s throat—about the size of a nickel. Healthy Eating There are many ways to divide the Daily ...

  16. Keeping Your Voice Healthy

    MedlinePLUS

    ... an ENT Doctor Near You Keeping Your Voice Healthy Keeping Your Voice Healthy Patient Health Information News ... voice-related. Key Steps for Keeping Your Voice Healthy Drink plenty of water. Moisture is good for ...

  17. Sister Mary Joseph Nodule: A Rare Presentation of Squamous Cell Carcinoma of the Cervix

    PubMed Central

    Tun, Nay Min; Yoe, Linus

    2015-01-01

    Background Sister Mary Joseph nodule refers to metastatic malignancy of the periumbilical region. Umbilical metastasis is an indicator of advanced malignant disease. Case Report We present the case of an 88-year-old patient presenting with postmenopausal vaginal bleeding, inguinal lymphadenopathy, and physical findings of a palpable umbilical nodule (Sister Mary Joseph nodule). Further workup was consistent with metastatic squamous cell carcinoma of the cervix. Conclusion Because Sister Mary Joseph nodule may be the only manifestation of underlying malignancy, thorough physical examination plays an important role in diagnosing the malignancy in a more confined state that may have a positive impact on the patient's length of survival. PMID:26412998

  18. Twin Talk: Manifestations of Twin Status in the Speech of Toddlers.

    ERIC Educational Resources Information Center

    Malmstrom, Patricia M.; Silva, Marilyn N.

    1986-01-01

    Crib-talk between identical twin girls and diary records of their speech were examined. It was found that the subjects developed conventional syntax and vocabulary but adapted them in ways which appropriately expressed their twin status. (Author/SED)

  19. Twins Eye Study in Tasmania (TEST): Rationale and Methodology to Recruit and Examine Twins

    PubMed Central

    Mackey, David A; MacKinnon, Jane R; Brown, Shayne A; Kearns, Lisa S; Ruddle, Jonathan B; Sanfilippo, Paul G; Sun, Cong; Hammond, Christopher J; Young, Terri L; Martin, Nicholas G; Hewitt, Alex W

    2013-01-01

    Visual impairment is a leading cause for morbidity and poor quality of life in our community. Unravelling the mechanisms underpinning important blinding diseases could allow for preventative or curative steps to be implemented. Twin siblings provide a unique opportunity in biology to discover genes associated with numerous eye diseases and ocular biometry. Twins are particularly useful for quantitative trait analysis through genome-wide association and linkage studies. Although many studies involving twins rely on twin registries, we present our approach to the Twins Eye Study in Tasmania to provide insight into possible recruitment strategies, expected participation rates and potential examination strategies that can be considered by other researchers for similar studies. Five separate avenues for cohort recruitment were adopted: 1) piggy-backing existing studies where twins had been recruited; 2); utilising the national twin registry; 3) word of mouth and local media publicity; 4) directly approaching schools; and finally 5) collaborating with other research groups studying twins. PMID:19803772

  20. Increased UV-induced sister-chromatid exchange in cultured fibroblasts of first-degree relatives of melanoma patients

    SciTech Connect

    Knees-Matzen, S.; Roser, M.; Reimers, U.; Ehlert, U.; Weichenthal, M.; Breitbart, E.W.; Ruediger, H.W. )

    1991-06-01

    Cultured fibroblasts of 17 first-degree relatives of familial melanoma patients and six first-degree relatives of cutaneous melanoma (CMM) patients with multiple CMM primaries were tested for in vitro sensitivity to UV light. Fibroblasts of nine familial CMM patients with a known UV-sensitivity and 19 healthy probands served as a control. Sister chromatid exchange (SCE) was used as a parameter to detect UV-induced genotoxic damage. The authors found significantly (p less than 0.001) increased UV-induced SCE levels in familial melanoma patients, as well as in first-degree relatives of familial melanoma patients (p less than 0.001) after UV-A,B irradiation (375 J/m2), compared to the healthy probands without a family history of CMM. A significant (p less than 0.001) increase of UV-induced SCE was also observed in the relatives of CMM patients with multiple CMM primaries. In addition, the spontaneous SCE were significantly increased (p less than 0.05) in familial CMM patients. This study shows that increased UV sensitivity is a familial phenomenon. It is consistent with the concept of a genetic predisposition to CMM, which is based on increased UV sensitivity and may help to define groups with an elevated risk of developing cutaneous malignant melanoma.

  1. Management of perinatal loss of a twin.

    PubMed Central

    Lewis, E.; Bryan, E. M.

    1988-01-01

    The death of a twin during pregnancy or around birth gives rise to a bewildering confusion of thoughts and feelings that can impede mourning and disturb the bereaved mother's care of a surviving twin. Every effort should be made to give the parents and siblings an experience of the dead baby. Photographs especially can reduce confusion and assist reality testing and thus facilitate the grieving process and improve the care of the surviving twin. PMID:3144377

  2. Anaesthesia for the separation of conjoined twins.

    PubMed

    Lalwani, Jaya; Dubey, Kp; Shah, Pratibha

    2011-03-01

    Thoraco-omphalopagus is one of the most common type of conjoint twins accounting for 74% cases of conjoint twins. We report the anaesthetic management for successful separation of thoraco-omphalopagus conjoint twins, both of them surviving till date. We highlight the responsibility of anaesthesia team in anaesthetising the two individual patients simultaneously, need of careful monitoring and anticipation of complications like massive blood loss, hypotension, hypokalemia, hypoxia and hypercabia. Detailed description of successful management is reported. PMID:21712878

  3. Partial Meissner effect in superconductors with twins

    SciTech Connect

    Gurevich, A.L.; Mints, R.G. )

    1988-11-01

    Superconductivity of twinning planes, arising at critical temperature T/sub c/ exceeding the bulk point T/sub co/, may prove to be important for the understanding of the properties of high-temperature superconductors with well-developed twinning structure. This paper shows that regardless of a specific mechanism of superconductivity, twins at T/sub c/>T/sub co/ act as seeds for the growth of metastable superconducting domains whose order parameter phases differ by {pi}.

  4. Ecologically distinct dinosaurian sister group shows early diversification of Ornithodira.

    PubMed

    Nesbitt, Sterling J; Sidor, Christian A; Irmis, Randall B; Angielczyk, Kenneth D; Smith, Roger M H; Tsuji, Linda A

    2010-03-01

    The early evolutionary history of Ornithodira (avian-line archosaurs) has hitherto been documented by incomplete (Lagerpeton) or unusually specialized forms (pterosaurs and Silesaurus). Recently, a variety of Silesaurus-like taxa have been reported from the Triassic period of both Gondwana and Laurasia, but their relationships to each other and to dinosaurs remain a subject of debate. Here we report on a new avian-line archosaur from the early Middle Triassic (Anisian) of Tanzania. Phylogenetic analysis places Asilisaurus kongwe gen. et sp. nov. as an avian-line archosaur and a member of the Silesauridae, which is here considered the sister taxon to Dinosauria. Silesaurids were diverse and had a wide distribution by the Late Triassic, with a novel ornithodiran bauplan including leaf-shaped teeth, a beak-like lower jaw, long, gracile limbs, and a quadrupedal stance. Our analysis suggests that the dentition and diet of silesaurids, ornithischians and sauropodomorphs evolved independently from a plesiomorphic carnivorous form. As the oldest avian-line archosaur, Asilisaurus demonstrates the antiquity of both Ornithodira and the dinosaurian lineage. The initial diversification of Archosauria, previously documented by crocodilian-line archosaurs in the Anisian, can now be shown to include a contemporaneous avian-line radiation. The unparalleled taxonomic diversity of the Manda archosaur assemblage indicates that archosaur diversification was well underway by the Middle Triassic or earlier. PMID:20203608

  5. Two sisters in the same dress: Heliconius cryptic species

    PubMed Central

    2008-01-01

    Background Sister species divergence and reproductive isolation commonly results from ecological adaptation. In mimetic Heliconius butterflies, shifts in colour pattern contribute to pre- and post-mating reproductive isolation and are commonly correlated with speciation. Closely related mimetic species are therefore not expected, as they should lack several important sources of reproductive isolation. Results Here we present phenotypic, behavioral and genetic evidence for the coexistence of two sympatric 'cryptic' species near Florencia in the eastern Andes of Colombia that share the same orange rayed colour pattern. These represent H. melpomene malleti and a novel taxon in the H. cydno group, here designated as novel race of Heliconius timareta, Heliconius timareta florencia. No-choice mating experiments show that these sympatric forms have strong assortative mating (?96%) despite great similarity in colour pattern, implying enhanced divergence in pheromonal signals. Conclusion We hypothesize that these species might have resulted from recent convergence in colour pattern, perhaps facilitated by hybrid introgression of wing pattern genes. PMID:19040737

  6. Sister chromatid exchanges in smokers and smokers with alcohol habit

    PubMed Central

    Kumar, J Vijay; Saraswathi, TR; Ranganathan, K; Umadevi, KM; Joshua, Elizabeth; Rooban, T

    2012-01-01

    Aim: Sister chromatid exchange (SCE) test is a sensitive, biomarker of genotoxic substances. The present study was conducted to observe the frequency of SCEs in peripheral blood lymphocytes of 30 males with and without the habit of cigarette smoking and alcohol consumption. Materials and Methods: Subjects for this study were males aged between 25-50 years and were selected from the students, employees and the patients attending the outpatient department of Ragas dental college and Hospital, Chennai. Results: Controls, smokers, and smokers with alcohol habit were divided into two age groups as ?30 years and ?30 years. In controls the mean frequency of SCEs/cell in ?30 years and ?30 year's age group was 5.80 and 6.05, respectively. In Smokers SCEs/cell in ?30 years and ?30 year's age group was 7.7 and 8.8, respectively. In Smokers with alcohol habit SCEs/cell in ?30 years and ?30 years age group was 10.1 and 12.8, respectively. Conclusions: In this study, the duration of the smoking habit has shown a positive correlation with the mean SCE frequency. Whereas, frequency of the habit did not show any influence on the SCE levels. In smokers with alcohol habit, both the duration and frequency of their smoking habit has shown a significant effect on the SCE levels suggesting a synergistic effect of alcohol and smoking leading to excessive DNA damage. PMID:23248461

  7. Chloroplast phylogenomics indicates that Ginkgo biloba is sister to cycads.

    PubMed

    Wu, Chung-Shien; Chaw, Shu-Miaw; Huang, Ya-Yi

    2013-01-01

    Molecular phylogenetic studies have not yet reached a consensus on the placement of Ginkgoales, which is represented by the only living species, Ginkgo biloba (common name: ginkgo). At least six discrepant placements of ginkgo have been proposed. This study aimed to use the chloroplast phylogenomic approach to examine possible factors that lead to such disagreeing placements. We found the sequence types used in the analyses as the most critical factor in the conflicting placements of ginkgo. In addition, the placement of ginkgo varied in the trees inferred from nucleotide (NU) sequences, which notably depended on breadth of taxon sampling, tree-building methods, codon positions, positions of Gnetopsida (common name: gnetophytes), and including or excluding gnetophytes in data sets. In contrast, the trees inferred from amino acid (AA) sequences congruently supported the monophyly of a ginkgo and Cycadales (common name: cycads) clade, regardless of which factors were examined. Our site-stripping analysis further revealed that the high substitution saturation of NU sequences mainly derived from the third codon positions and contributed to the variable placements of ginkgo. In summary, the factors we surveyed did not affect results inferred from analyses of AA sequences. Congruent topologies in our AA trees give more confidence in supporting the ginkgo-cycad sister-group hypothesis. PMID:23315384

  8. INCREASED TWINNING AND COW PRODUCTIVITY IN BEEF CATTLE SELECTED FOR OVULATION AND TWINNING RATE

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Since 1981, cattle have been selected for fraternal twin births using estimated breeding values for twinning calculated from repeated measurements of ovulation rate in all heifer progeny starting at about 12 months of age, from twinning rate in the selected females, and from progeny testing and sub...

  9. Twin Loss: Implications for Counselors Working with Surviving Twins.(practice & Theory)

    ERIC Educational Resources Information Center

    Withrow, Rebecca; Schwiebert, Valerie L.

    2005-01-01

    Multiple births are becoming increasingly prevalent due to the use of fertility drugs and women choosing to wait until later life to conceive. With the growth in the twin population, little research has been done to investigate the effects on the grief process when 1 twin dies. Counselors must understand the unique experience of twins to formulate…

  10. Management of twins: vaginal or cesarean delivery?

    PubMed

    Bibbo, Carolina; Robinson, Julian N

    2015-06-01

    Recent level I evidence from a single randomized-controlled trial has shown that there is no difference in fetal or neonatal outcomes (composite of fetal/neonatal death or serious neonatal morbidity) between planned cesarean delivery and planned vaginal delivery for twins between 32 and 38 6/7 weeks. As long as the presenting twin is vertex, vaginal delivery should be considered regardless of the presentation of the second twin. To avoid unnecessary cesarean deliveries and maternal morbidity, it is important to continue to train residents to perform obstetrics maneuvers necessary for vaginal delivery of twins such as vaginal breech extraction. PMID:25851847

  11. Twin Cities Metro Advanced Practice Center

    E-print Network

    EEqquuiippmmeenntt aanndd SSuupppplliieess:: Flashlight Battery-operated radio /TV and batteries Garbage bags Offsite cold storage options (contact info for truck, warehouse) #12;Twin Cities Metro Advanced Practice

  12. Nanoscale Growth Twins in Sputtered Copper Films 

    E-print Network

    Anderoglu, Osman

    2011-08-08

    twins ....................................................................... 47 II EXPERIMENTAL TECHNIQUES ..................................................... 52 II.1. Fabrication of nanotwinned Cu films... ......................................... 52 II.2. Microstructural characterization of nanotwinned Cu thin films ................................................................................ 56 vii CHAPTER...

  13. Atomistic deformation mechanisms in twinned copper nanospheres.

    PubMed

    Bian, Jianjun; Niu, Xinrui; Zhang, Hao; Wang, Gangfeng

    2014-01-01

    In the present study, we perform molecular dynamic simulations to investigate the compression response and atomistic deformation mechanisms of twinned nanospheres. The relationship between load and compression depth is calculated for various twin spacing and loading directions. Then, the overall elastic properties and the underlying plastic deformation mechanisms are illuminated. Twin boundaries (TBs) act as obstacles to dislocation motion and lead to strengthening. As the loading direction varies, the plastic deformation transfers from dislocations intersecting with TBs, slipping parallel to TBs, and then to being restrained by TBs. The strengthening of TBs depends strongly on the twin spacing. PMID:25024693

  14. Common plankton of Twin Lakes, Colorado

    SciTech Connect

    Lieberman, D.M.

    1983-02-01

    A series of studies is being performed to evaluate the effects of the Mt. Elbert Pumped-Storage Powerplant on the ecology of Twin Lakes. Twin Lakes are a pair of connected dimictic lakes, formed as the result of glacial action on alluvial deposits. This report presents a taxonomic species study of the common plankton collected since 1974 from Twin Lakes. A total of 11 zooplankters and 14 phytoplankters were identified from the limnetic zone of Twin Lakes and the associated Mt. Elbert Forebay. The four divisions of zooplankton included four species of Rotifera (rotifer), three species of Copepoda (copepod), three species of Cladocera (cladoceran), and one species of Mysidacea (opossum shrimp).

  15. Atomistic deformation mechanisms in twinned copper nanospheres

    PubMed Central

    2014-01-01

    In the present study, we perform molecular dynamic simulations to investigate the compression response and atomistic deformation mechanisms of twinned nanospheres. The relationship between load and compression depth is calculated for various twin spacing and loading directions. Then, the overall elastic properties and the underlying plastic deformation mechanisms are illuminated. Twin boundaries (TBs) act as obstacles to dislocation motion and lead to strengthening. As the loading direction varies, the plastic deformation transfers from dislocations intersecting with TBs, slipping parallel to TBs, and then to being restrained by TBs. The strengthening of TBs depends strongly on the twin spacing. PMID:25024693

  16. Impact of Early Environment on Children's Mental Health: Lessons From DNA Methylation Studies With Monozygotic Twins.

    PubMed

    Chiarella, Julian; Tremblay, Richard E; Szyf, Moshe; Provençal, Nadine; Booij, Linda

    2015-12-01

    Over the past decade, epigenetic analyses have made important contributions to our understanding of healthy development and a wide variety of adverse conditions such as cancer and psychopathology. There is increasing evidence that DNA methylation is a mechanism by which environmental factors influence gene transcription and, ultimately, phenotype. However, differentiating the effects of the environment from those of genetics on DNA methylation profiles remains a significant challenge. Monozygotic (MZ) twin study designs are unique in their ability to control for genetic differences because each pair of MZ twins shares essentially the same genetic sequence with the exception of a small number of de novo mutations and copy number variations. Thus, differences within twin pairs in gene expression and phenotype, including behavior, can be attributed in the majority of cases to environmental effects rather than genetic influence. In this article, we review the literature showing how MZ twin designs can be used to study basic epigenetic principles, contributing to understanding the role of early in utero and postnatal environmental factors on the development of psychopathology. We also highlight the importance of initiating longitudinal and experimental studies with MZ twins during pregnancy. This approach is especially important to identify: (1) critical time periods during which the early environment can impact brain and mental health development, and (2) the specific mechanisms through which early environmental effects may be mediated. These studies may inform the optimum timing and design for early preventive interventions aimed at reducing risk for psychopathology. PMID:26608878

  17. Phylogenetic systematics of Glassfrogs (Amphibia: Centrolenidae) and their sister taxon Allophryne ruthveni

    E-print Network

    Guayasamin, Juan Manuel; Castroviejo-Fisher, Santiago; Trueb, Linda; Ayarzagü ena, José Rada, Marco; Vilà , Carles

    2009-05-11

    Based on a molecular phylogeny, a new phylogenetic taxonomy that is compatible with both the International Code of Zoological Nomenclature (ICZN) and the PhyloCode is proposed for Glassfrogs and their sister taxon, Allophryne ...

  18. Catholic Nursing Sisters and Brothers and Racial Justice in Mid-20th-Century America

    PubMed Central

    Wall, Barbra Mann

    2009-01-01

    This historical article considers nursing’s work for social justice in the 1960s civil rights movement through the lens of religious sisters and brothers who advocated for racial equality. The article examines Catholic nurses’ work with African Americans in the mid-20th century that took place amid the prevailing social conditions of poverty and racial disempowerment, conditions that were linked to serious health consequences. Historical methodology is used within the framework of “bearing witness,” a term often used in relation to the civil rights movement and one the sisters themselves employed. Two situations involving nurses in the mid-20th century are examined: the civil rights movement in Selma, Alabama, and the actions for racial justice in Chicago, Illinois. The thoughts and actions of Catholic sister and brother nurses in the mid-20th century are chronicled, including those few sister nurses who stepped outside their ordinary roles in an attempt to change an unjust system entirely. PMID:19461224

  19. 20 CFR 410.340 - Determination of relationship; parent, brother, or sister.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    20 Employees' Benefits 2 2010-04-01 ...410.340 Employees' Benefits SOCIAL SECURITY ADMINISTRATION...TITLE IV-BLACK LUNG BENEFITS (1969- ) Relationship...sister of the miner by adoption. [37 FR 20639,...

  20. Catholic nursing sisters and brothers and racial justice in mid-20th-century America.

    PubMed

    Wall, Barbra Mann

    2009-01-01

    This historical article considers nursing's work for social justice in the 1960s civil rights movement through the lens of religious sisters and brothers who advocated for racial equality. The article examines Catholic nurses' work with African Americans in the mid-20th century that took place amid the prevailing social conditions of poverty and racial disempowerment, conditions that were linked to serious health consequences. Historical methodology is used within the framework of "bearing witness," a term often used in relation to the civil rights movement and one the sisters themselves employed. Two situations involving nurses in the mid-20th century are examined: the civil rights movement in Selma, Alabama, and the actions for racial justice in Chicago, Illinois. The thoughts and actions of Catholic sister and brother nurses in the mid-20th century are chronicled, including those few sister nurses who stepped outside their ordinary roles in an attempt to change an unjust system entirely. PMID:19461224

  1. 20 CFR 725.223 - Duration of entitlement; parent, brother, or sister.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... the parent dies. (c) The last month for which such brother or sister is entitled to benefits is the month before the month in which any of the following events first occurs: (1) The individual dies;...

  2. Radiologic findings of Patterson-Lowry rhizomelic dysplasia in two sisters.

    PubMed

    Damar, Ça?r?; Boyuna?a, Öznur; Derinkuyu, Betül Emine; Battalo?lu, Nergiz; Ezgü, Fatih Süheyl

    2014-11-01

    We report two sisters who have a rare skeletal abnormality termed Patterson-Lowry rhizomelic dysplasia. The typical findings of these cases on bone survey are isolated shortening and proximal metaphyseal enlargement and cupping of the bilateral humeri. The elder sister also has coxa vara deformity and dysplastic proximal femoral epiphyses on both sides. The younger sister has normal hip joint bones bilaterally, but her proximal femoral epiphyses are smaller than normal. All other bones of the sisters are of normal size and configuration. Our patients are two siblings, and their parents are first degree relatives, suggesting autosomal-recessive (AR) inheritance. The present patients help us to understand the genetic relationships and skeletal variabilities of this rare entity. PMID:25037730

  3. A novel mechanism for the establishment of sister chromatid cohesion by the ECO1 acetyltransferase

    E-print Network

    Guo, Xuanzong

    Cohesin complex mediates cohesion between sister chromatids, which promotes high-fidelity chromosome segregation. Eco1p acetylates the cohesin subunit Smc3p during S phase to establish cohesion. The current model posits ...

  4. 12. Photographic copy of copy of Twin Lakes Outlet Works ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. Photographic copy of copy of Twin Lakes Outlet Works construction drawing dated January 15, 1951. Drawn by W.A. Doe for the Twin Lakes Reservoir and Canal Co. (copy in possession of Bureau of Reclamation, location of original unknown) 'AS CONSTRUCTED' PLANS OF 1949-50, REHABILITATION OF TWIN LAKES RESERVOIR OUTLET WORKS, DETAILS OF DISCHARGE BASIN. - Twin Lakes Dam & Outlet Works, Beneath Twin Lakes Reservoir, T11S, R80W, S22, Twin Lakes, Lake County, CO

  5. 11. Photographic copy of copy of Twin Lakes Outlet Works ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. Photographic copy of copy of Twin Lakes Outlet Works construction drawing dated January 15, 1951. Drawn by W.A. Doe for the Twin Lakes Reservoir and Canal Co. (copy in possession of Bureau of Reclamation, location of original unknown) 'AS CONSTRUCTED' PLANS OF 1949-1950, REHABILITATION OF TWIN LAKES RESERVOIR OUTLET WORKS, DETAILS OF UPSTREAM WING WALLS. - Twin Lakes Dam & Outlet Works, Beneath Twin Lakes Reservoir, T11S, R80W, S22, Twin Lakes, Lake County, CO

  6. Flying lemurs - the "flying tree shrews"? Molecular cytogenetic evidence for a Scandentia-Dermoptera sister clade

    E-print Network

    Nie, Wenhui; Fu, Beiyuan; O'Brien, Patricia C. M.; Wang, Jinhuan; Su, Weiting; Tanomtong, Alongklod; Volobouev, Vitaly; Ferguson-Smith, Malcolm A.; Yang, Fengtang

    2008-05-01

    Research article Flying lemurs – The 'flying tree shrews'? Molecular cytogenetic evidence for a Scandentia-Dermoptera sister clade Wenhui Nie1, Beiyuan Fu2, Patricia CM O'Brien2, Jinhuan Wang1, Weiting Su1, Alongkoad Tanomtong3, Vitaly Volobouev4, Malcolm A... ]; (e) a closer relationship between Scandentia and Dermoptera [4-7,22]. Furthermore, based on some intriguing similarities in morphology and molecular data, a sister-group relationship between tree shrews (Scanden- tia) and lagomorphs (Lagomorpha) has...

  7. Genomic data do not support comb jellies as the sister group to all other animals.

    PubMed

    Pisani, Davide; Pett, Walker; Dohrmann, Martin; Feuda, Roberto; Rota-Stabelli, Omar; Philippe, Hervé; Lartillot, Nicolas; Wörheide, Gert

    2015-12-15

    Understanding how complex traits, such as epithelia, nervous systems, muscles, or guts, originated depends on a well-supported hypothesis about the phylogenetic relationships among major animal lineages. Traditionally, sponges (Porifera) have been interpreted as the sister group to the remaining animals, a hypothesis consistent with the conventional view that the last common animal ancestor was relatively simple and more complex body plans arose later in evolution. However, this premise has recently been challenged by analyses of the genomes of comb jellies (Ctenophora), which, instead, found ctenophores as the sister group to the remaining animals (the "Ctenophora-sister" hypothesis). Because ctenophores are morphologically complex predators with true epithelia, nervous systems, muscles, and guts, this scenario implies these traits were either present in the last common ancestor of all animals and were lost secondarily in sponges and placozoans (Trichoplax) or, alternatively, evolved convergently in comb jellies. Here, we analyze representative datasets from recent studies supporting Ctenophora-sister, including genome-scale alignments of concatenated protein sequences, as well as a genomic gene content dataset. We found no support for Ctenophora-sister and conclude it is an artifact resulting from inadequate methodology, especially the use of simplistic evolutionary models and inappropriate choice of species to root the metazoan tree. Our results reinforce a traditional scenario for the evolution of complexity in animals, and indicate that inferences about the evolution of Metazoa based on the Ctenophora-sister hypothesis are not supported by the currently available data. PMID:26621703

  8. Ecological divergence and speciation between lemur (Eulemur) sister species in Madagascar.

    PubMed

    Blair, M E; Sterling, E J; Dusch, M; Raxworthy, C J; Pearson, R G

    2013-08-01

    Understanding ecological niche evolution over evolutionary timescales is crucial to elucidating the biogeographic history of organisms. Here, we used, for the first time, climate-based ecological niche models (ENMs) to test hypotheses about ecological divergence and speciation processes between sister species pairs of lemurs (genus Eulemur) in Madagascar. We produced ENMs for eight species, all of which had significant validation support. Among the four sister species pairs, we found nonequivalent niches between sisters, varying degrees of niche overlap in ecological and geographic space, and support for multiple divergence processes. Specifically, three sister-pair comparisons supported the null model that niches are no more divergent than the available background region. These findings are consistent with an allopatric speciation model, and for two sister pairs (E. collaris-E. cinereiceps and E. rufus-E. rufifrons), a riverine barrier has been previously proposed for driving allopatric speciation. However, for the fourth sister pair E. flavifrons-E. macaco, we found support for significant niche divergence, and consistent with their parapatric distribution on an ecotone and the lack of obvious geographic barriers, these findings most strongly support a parapatric model of speciation. These analyses thus suggest that various speciation processes have led to diversification among closely related Eulemur species. PMID:23865477

  9. Genomic data do not support comb jellies as the sister group to all other animals

    PubMed Central

    Pisani, Davide; Pett, Walker; Dohrmann, Martin; Feuda, Roberto; Rota-Stabelli, Omar; Philippe, Hervé; Lartillot, Nicolas; Wörheide, Gert

    2015-01-01

    Understanding how complex traits, such as epithelia, nervous systems, muscles, or guts, originated depends on a well-supported hypothesis about the phylogenetic relationships among major animal lineages. Traditionally, sponges (Porifera) have been interpreted as the sister group to the remaining animals, a hypothesis consistent with the conventional view that the last common animal ancestor was relatively simple and more complex body plans arose later in evolution. However, this premise has recently been challenged by analyses of the genomes of comb jellies (Ctenophora), which, instead, found ctenophores as the sister group to the remaining animals (the “Ctenophora-sister” hypothesis). Because ctenophores are morphologically complex predators with true epithelia, nervous systems, muscles, and guts, this scenario implies these traits were either present in the last common ancestor of all animals and were lost secondarily in sponges and placozoans (Trichoplax) or, alternatively, evolved convergently in comb jellies. Here, we analyze representative datasets from recent studies supporting Ctenophora-sister, including genome-scale alignments of concatenated protein sequences, as well as a genomic gene content dataset. We found no support for Ctenophora-sister and conclude it is an artifact resulting from inadequate methodology, especially the use of simplistic evolutionary models and inappropriate choice of species to root the metazoan tree. Our results reinforce a traditional scenario for the evolution of complexity in animals, and indicate that inferences about the evolution of Metazoa based on the Ctenophora-sister hypothesis are not supported by the currently available data. PMID:26621703

  10. Growth of deformation twins in tantalum via coherent twin boundary migration

    NASA Astrophysics Data System (ADS)

    Sandoval, Luis A.; Surh, Michael P.; Chernov, Alexander A.; Richards, David F.

    2013-09-01

    In order to investigate the process of twinning growth, the nucleation of twinning dislocation loops on the coherent boundary of a Tantalum twin superlattice is studied via a molecular dynamics approach. We get homogeneous nucleation rates by means of a stationarity test and the mean first-passage method. We study their dependence on driving force and temperature in a framework given by the Kolgomorov-Johnson-Mehl-Avrami theory. Correspondingly, the contribution to the twinning growth dictated by this nucleation mechanism, as compared to the pole mechanism, is discussed. The homogeneous loop nucleation and growth mechanism can be relevant to twinning in high strain-rate experiments as in shock waves.

  11. Solution Radioactivated by Hadron Radiation Can Increase Sister Chromatid Exchanges

    PubMed Central

    Maeda, Junko; Yurkon, Charles R.; Fujii, Yoshihiro; Fujisawa, Hiroshi; Kato, Sayaka; Brents, Colleen A.; Uesaka, Mitsuru; Fujimori, Akira; Kitamura, Hisashi; Kato, Takamitsu A.

    2015-01-01

    When energetic particles irradiate matter, it becomes activated by nuclear reactions. Radioactivation induced cellular effects are not clearly understood, but it could be a part of bystander effects. This investigation is aimed at understanding the biological effects from radioactivation in solution induced by hadron radiation. Water or phosphate buffered saline was activated by being exposed to hadron radiation including protons, carbon- and iron-ions. 1 mL of radioactivated solution was transferred to flasks with Chinese hamster ovary (CHO) cells cultured in 5 mL of complete media. The induction of sister chromatid exchanges (SCE) was used to observe any increase in DNA damage responses. The energy spectrum and the half-lives of the radioactivation were analyzed by NaI scintillation detector in order to identify generated radionuclides. In the radioactivated solution, 511 keV gamma-rays were observed, and their half-lives were approximately 2 min, 10 min, and 20 min. They respectively correspond to the beta+ decay of 15O, 13N, and 11C. The SCE frequencies in CHO cells increased depending on the amount of radioactivation in the solution. These were suppressed with a 2-hour delayed solution transfer or pretreatment with dimethyl sulfoxide (DMSO). Our results suggest that the SCE induction by radioactivated solution was mediated by free radicals produced by the annihilated gamma-rays. Since the SCE induction and DMSO modulation are also reported in radiation-induced bystander effects, our results imply that radioactivation of the solution may have some contribution to the bystander effects from hadron radiation. Further investigations are required to assess if radioactivation effects would attribute an additional level of cancer risk of the hadron radiation therapy itself. PMID:26657140

  12. Partial Dosage Compensation in Strepsiptera, a Sister Group of Beetles

    PubMed Central

    Mahajan, Shivani; Bachtrog, Doris

    2015-01-01

    Sex chromosomes have evolved independently in many different taxa, and so have mechanisms to compensate for expression differences on sex chromosomes in males and females. Different clades have evolved vastly different ways to achieve dosage compensation, including hypertranscription of the single X in male Drosophila, downregulation of both X’s in XX Caenorhabditis, or inactivation of one X in female mammals. In the flour beetle Tribolium, the X appears hyperexpressed in both sexes, which might represent the first of two steps to evolve dosage compensation along the paths mammals may have taken (i.e., upregulation of X in both sexes, followed by inactivation of one X in females). Here we test for dosage compensation in Strepsiptera, a sister taxon to beetles. We identify sex-linked chromosomes in Xenos vesparum based on genomic analysis of males and females, and show that its sex chromosome consists of two chromosomal arms in Tribolium: The X chromosome that is shared between Tribolium and Strepsiptera, and another chromosome that is autosomal in Tribolium and another distantly related Strepsiptera species, but sex-linked in X. vesparum. We use RNA-seq (RNA sequencing) to show that dosage compensation along the X of X. vesparum is partial and heterogeneous. In particular, genes that are X-linked in both beetles and Strepsiptera appear fully dosage compensated probably through downregulation in both sexes, whereas genes on the more recently added X segment have evolved only partial dosage compensation. In addition, reanalysis of published RNA-seq data suggests that Tribolium has evolved dosage compensation, without hypertranscribing the X in females. Our results demonstrate that patterns of dosage compensation are highly variable across sex-determination systems and even within species. PMID:25601100

  13. Cohesin-independent segregation of sister chromatids in budding yeast

    PubMed Central

    Guacci, Vincent; Koshland, Douglas

    2012-01-01

    Cohesin generates cohesion between sister chromatids, which enables chromosomes to form bipolar attachments to the mitotic spindle and segregate. Cohesin also functions in chromosome condensation, transcriptional regulation, and DNA damage repair. Here we analyze the role of acetylation in modulating cohesin functions and how it affects budding yeast viability. Previous studies show that cohesion establishment requires Eco1p-mediated acetylation of the cohesin subunit Smc3p at residue K113. Smc3p acetylation was proposed to promote establishment by merely relieving Wpl1p inhibition because deletion of WPL1 bypasses the lethality of an ECO1 deletion (eco1? wpl1?). We find that little, if any, cohesion is established in eco1? wpl1? cells, indicating that Eco1p performs a function beyond antagonizing Wpl1p. Cohesion also fails to be established when SMC3 acetyl-mimics (K113Q or K112R,K113Q) are the sole functional SMC3s in cells. These results suggest that Smc3p acetylation levels affect establishment. It is remarkable that, despite their severe cohesion defect, eco1? wpl1? and smc3-K112R,K113Q strains are viable because a cohesin-independent mechanism enables bipolar attachment and segregation. This alternative mechanism is insufficient for smc3-K113Q strain viability. Smc3-K113Q is defective for condensation, whereas eco1? wpl1? and smc3-K112R,K113Q strains are competent for condensation. We suggest that Smc3p acetylation and Wpl1p antagonistically regulate cohesin's essential role in condensation. PMID:22190734

  14. NOTE: Haemodynamic resistance model of monochorionic twin pregnancies complicated by acardiac twinning

    NASA Astrophysics Data System (ADS)

    Umur, Asli; van Gemert, Martin J. C.; van den Wijngaard, Jeroen P. H. M.; Ross, Michael G.; Nikkels, Peter G. J.

    2004-07-01

    An acardiac twin is a severely malformed monochorionic twin fetus that lacks most organs, particularly a heart. It grows during pregnancy, because it is perfused by its developmentally normal co-twin (called the pump twin) via a set of placental arterioarterial and venovenous anastomoses. The pump twin dies intrauterine or neonatally in about 50% of the cases due to congestive heart failure, polyhydramnios and prematurity. Because the pathophysiology of this pregnancy is currently incompletely understood, we modified our previous haemodynamic model of monochorionic twins connected by placental vascular anastomoses to include the analysis of acardiac twin pregnancies. We incorporated the fetoplacental circulation as a resistance circuit and used the fetal umbilical flow that perfuses the body to define fetal growth, rather than the placental flow as done previously. Using this modified model, we predicted that the pump twin has excess blood volume and increased mean arterial blood pressure compared to those in the acardiac twin. Placental perfusion of the acardiac twin is significantly reduced compared to normal, as a consequence of an increased venous pressure, possibly implying reduced acardiac placental growth. In conclusion, the haemodynamic analysis may contribute to an increased knowledge of the pathophysiologic consequences of an acardiac body mass for the pump twin.

  15. Attractiveness Differences Between Twins Predicts Evaluations of Self and Co-Twin

    PubMed Central

    Principe, Connor P.; Rosen, Lisa H.; Taylor-Partridge, Teresa; Langlois, Judith H.

    2012-01-01

    One of the most consistent findings in psychology shows that people prefer and make positive attributions about attractive compared with unattractive people. The goal of the current study was to determine the power of attractiveness effects by testing whether these social judgments are made where attractiveness differences are smallest: between twins. Differences in facial attractiveness predicted twins’ evaluations of self and their co-twin (n = 158; 54 male). In twin pairs, the more attractive twin judged their less attractive sibling as less physically attractive, athletic, socially competent, and emotionally stable. The less attractive twin did the reverse. Given that even negligible differences in facial attractiveness predicted self and co-twin attitudes, these results provide the strongest test yet of appearance-based stereotypes. PMID:23467329

  16. Twin-Foucault imaging method

    NASA Astrophysics Data System (ADS)

    Harada, Ken

    2012-02-01

    A method of Lorentz electron microscopy, which enables observation two Foucault images simultaneously by using an electron biprism instead of an objective aperture, was developed. The electron biprism is installed between two electron beams deflected by 180° magnetic domains. Potential applied to the biprism deflects the two electron beams further, and two Foucault images with reversed contrast are then obtained in one visual field. The twin Foucault images are able to extract the magnetic domain structures and to reconstruct an ordinary electron micrograph. The developed Foucault method was demonstrated with a 180° domain structure of manganite La0.825Sr0.175MnO3.

  17. Identical twins with lumbosacral lipomyelomeningocele.

    PubMed

    Hanaei, Sara; Nejat, Farideh; Mortazavi, Abolghasem; Habibi, Zohreh; Esmaeili, Arash; El Khashab, Mostafa

    2015-01-01

    Lipomyelomeningocele, a congenital spine defect, is presented as skin-covered lipomatous tissue that attaches to the cord in different ways according to its subtypes. Unlike other types of neural tube defects, the exact cause of this birth defect has not been confirmed yet, but it is proposed to be a multifactorial disease with involvement of both genetic and environmental factors. The authors describe identical twins with lipomyelomeningocele of the same subtype and location without any familial history of similar abnormality. Therefore, the same genetic and/or environmental risk factors could have played a part in their condition. PMID:25396701

  18. Ectodermal dysplasia in identical twins

    PubMed Central

    Puttaraju, Gurkar Haraswarupa; Visveswariah, Paranjyothi Magadi

    2013-01-01

    Hereditary hypohidrotic ectodermal dysplasia (HED) is typically inherited as an X-linked recessive trait, characterized by deformity of at least two or more of the ectodermal structures - hair, teeth, nails and sweat glands. Two cases of hereditary HED involving identical male twins, is being documented for the rarity of its occurrence with special attention given to genetics, pathophysiology, clinical, intraoral manifestations and to the methods to improve the masticatory function, the facial esthetics and psychology of patients affected by this disease. PMID:23956595

  19. Multiples: Twins, Triplets and Beyond

    MedlinePLUS

    ... Spotlight Become a youth volunteer leader World Prematurity Day World Prematurity Your support helps babies We are ... healthy foods and taking your prenatal vitamin every day. Prenatal vitamins are multivitamins made just for pregnant ...

  20. [Hungarian twin studies: results of four decades].

    PubMed

    Tárnoki, Ádám Domonkos; Tárnoki, Dávid László; Horváth, Tamás; Métneki, Júlia; Littvay, Levente

    2013-10-01

    Twin studies play a role in examining the contribution of genetic variations and environmental factors responsible for the determination of phenotypic variables and of genetic linkage between genotypes. Hungarian twin studies, supported by three twin registries (among them two twin-database), date back to 1970s. Studies mainly focused on various congenital abnormalities, the effect of contraceptive pills and folic acid on the frequency of twin pregnancies, as well as psychosexual and alcohol consumptional behaviors. Monogenic Mendelian inheritance of lactose (mal)absorption was demonstrated for the first time. Hungarian Twin Registry was founded in 2007, which contributed to the current understanding on the background of several disorders, e.g. metabolic syndrome and atherosclerosis. As part of an international twin study, among others, arterial stiffness, central blood pressure, carotid intima/media thickness, venous biomechanics, body composition, lung function and smoking characteristics were also assessed. Absence of genetic background in non-alcoholic fatty liver disease and high inheritance of carotid plaque characteristics were demonstrated for the first time. The review also aims to summarize future plans of the Hungarian Twin Registry. PMID:24077161

  1. 49 CFR 372.221 - Twin Cities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 5 2010-10-01 2010-10-01 false Twin Cities. 372.221 Section 372.221... ZONES, AND TERMINAL AREAS Commercial Zones § 372.221 Twin Cities. For the purpose of determining... following combinations of cities shall be considered as a single municipality: (a) Having a population...

  2. "The Bell Curve" on Separated Twins.

    ERIC Educational Resources Information Center

    Fancher, Raymond E.

    1995-01-01

    "The Bell Curve" declares that studies of separated identical twins--the "purest" of "direct" methods for estimating IQ heritability--indicate a value of +.75-+.80. But, the main study cited suggests a heritability of "two-thirds" for the middle class, and Herrnstein and Murray neglect to mention numerous complicating factors in twin studies that…

  3. Statistical mechanics analysis of the ``twins paradox''

    NASA Astrophysics Data System (ADS)

    Ben-Ya'Acov, Uri

    1995-12-01

    The aging of the two brothers in the “twins paradox” is analyzed through the space-time evolution of the densities that correspond to their internal complex structure. Taking into account their relative motion, it is shown that the traveling brother evolves over a shorter interval of time than his twin, which makes him younger than his brother.

  4. Entropic interaction between fluctuating twin boundaries

    NASA Astrophysics Data System (ADS)

    Chen, Dengke; Kulkarni, Yashashree

    2015-11-01

    Nanotwinned metals have opened up exciting avenues for the design of high-strength, high-ductility materials owing to the extraordinary properties of twin boundaries. The recent advances in the fabrication of nanostructured materials with twin lamella on the order of a mere few atomic layers call for a closer examination of the stability of these structural motifs, especially at high temperatures. This paper presents a study of the entropic interaction between fluctuating twin boundaries by way of atomistic simulations and statistical mechanics based analysis. The simulations reveal that fluctuations of twin boundaries are considerably enhanced in the presence of adjoining twin boundaries as their spacing, d, decreases. In addition, the theoretical analysis shows that fluctuating twin boundaries indeed exhibit an attractive entropic interaction which enhances their thermal fluctuations and that the entropic force decreases as 1 /d2. This finite temperature interaction between twin boundaries is fundamentally distinct from the well-known repulsive entropic interaction followed by fluctuating lipid membranes as well as many crystalline membranes and interfaces. This rather surprising attraction between fluctuating twin boundaries is attributed to their shear coupled normal motion.

  5. A male twin infant with skull deformity and elevated neonatal 17-hydroxyprogesterone: a prismatic case of P450 oxidoreductase deficiency.

    PubMed

    Wudy, Stefan A; Hartmann, Michaela F; Draper, Nicole; Stewart, Paul M; Arlt, Wiebke

    2004-11-01

    We report on a male twin infant who presented with brachy-turri-cephaly, frontal bossing, large anterior fontanelle, low set and malformed ears, and mild arachnodactyly. He had normal male genitalia. There was no evidence for maternal virilization during pregnancy. The pattern of malformations resembled Antley-Bixler-Syndrome (ABS). However, sequencing analysis of the fibroblast growth factor receptor 2 gene (FGFR2) did not reveal mutations. The boy's twin sister did not show any somatic or endocrine abnormalities. In the boy, neonatal screening for congenital adrenal hyperplasia was positive with moderately elevated 17-hydroxyprogesterone. Sequence analysis of his CYP21 gene did not reveal any mutations. The short synacthen test revealed an exaggerated 17-hydroxyprogesterone and a blunted cortisol response. Urinary steroid profiling by gas chromatography-mass spectrometry (GC-MS) revealed a unique steroid metabolome suggestive of impaired activity of both 17-hydroxylase and 21-hydroxylase. Clinical and metabolic findings therefore were compatible with the recently described variant of congenital adrenal hyperplasia, P450 oxidoreductase deficiency (ORD). Subsequently, sequencing analysis of CPR, the gene encoding P450 oxidoreductase (OR), revealed a homozygous mutation in the patient, resulting in an amino acid exchange in position 284 of the OR protein (A284P). Both the female twin sister and the parents were heterozygous for the A284P mutation. P450 oxidoreductase deficiency represents a novel autosomal recessively inherited form of congenital adrenal hyperplasia. Its characteristic steroid metabolome can readily be detected by GC-MS analysis of spot urine. Clinical features may include an ABS phenotype, ambiguous genitalia (virilization in girls, feminization in boys), and glucocorticoid deficiency. If required, hydrocortisone replacement should be provided. PMID:15666853

  6. Healthy Eating with Diabetes Video

    MedlinePLUS Videos and Cool Tools

    ... Healthy Eating with Diabetes Video Healthy Eating with Diabetes Video Making changes in the way you eat ... help you manage your weight. Healthy Eating with Diabetes Subtitle Healthy Eating with Diabetes Transcript Healthy Eating ...

  7. Silicic Eruptions of the Past 50 kyr at the Three Sisters Volcanic Cluster

    NASA Astrophysics Data System (ADS)

    Calvert, A. T.; Hildreth, W.; Fierstein, J.

    2003-12-01

    The Three Sisters volcanic cluster in the central Oregon Cascades consists of mafic to intermediate stratovolcanoes surrounded by mafic and silicic flows and domes. The bulk of South and Middle Sister are late Pleistocene while North Sister is middle Pleistocene (Schmidt and Grunder, 2003 GSA abs.). Thick rhyolite and dacite lava flows and domes are rich in potassium, and young glaciation exposes holocrystalline groundmass textures ideal for argon geochronology. Several of these silicic flows bracket stratovolcano growth, and precise geochronology illuminates a rich basalt to rhyolite history in the cluster over the past 50 kyr. Careful step-heating 40Ar/39Ar experiments yield excellent plateau ages with radiogenic yields often above 5% on rocks as young as 20 ka. Most samples have well-determined isochrons with atmospheric (40/36 = 295.5) intercepts, although several have intercepts as low as 286. South Sister is a composite cone with an andesite/dacite base (Hodge Crest) and a young andesite summit sequence. The basal flow of the 300m-thick, youngest conformable stack of andesite lavas at the summit is 27+/-3 ka. Unconformably underlying portions date back to at least 50 ka based on ages of overlapping silicic flows. The base of Middle Sister is andesite overlain by ˜300m of olivine basalt. Some Middle Sister andesites and all basalts overlie a distinctive dacite agglutinate (20+/-2 ka) in the South/Middle Sister saddle. All Middle Sister lavas underlie a thick dacite flow (14+/-3 ka) that vented at 8500 ft (2600m) on its S flank. Dacite lava flows erupted from the Middle/North Sister saddle at 27+/-2 and 18+/-2 ka. Additionally, several >100m-thick rhyolite and dacite lavas vented low on the flanks of the cluster. Obsidian Cliff rhyolite (37.8+/-1.8 ka) and Lane Plateau dacite (21.4+/-1.9 ka) erupted W of Middle Sister, the Dew Lake dacite (32.3+/-1.8 ka) located near the locus of the INSAR anomaly W of South Sister flowed around a 148+/-4 ka (knob 6482) basalt and near the 149+/-5 ka (The Husband), 159+/-10 ka (Upper Mesa Creek) and 279+/-6 ka (The Sphinx) basalts. The south flank of South Sister is dominated by the late Holocene rhyolites of Rock Mesa and the Devil's Hill chain and about ten 24-50 ka rhyolite and dacite domes and flows. A 100m-thick 35+/-2 ka rhyolite lava also extends NE from South Sister into Squaw Creek. In sum, South and Middle Sisters are mafic to intermediate and their youngest activity is coeval. Silicic flows on and around the volcanic cluster are voluminous, abundant and young.

  8. Niobium and tantalum: indispensable twins

    USGS Publications Warehouse

    Schulz, Klaus; Papp, John

    2014-01-01

    Niobium and tantalum are transition metals almost always paired together in nature. These “twins” are difficult to separate because of their shared physical and chemical properties. In 1801, English chemist Charles Hatchett uncovered an unknown element in a mineral sample of columbite; John Winthrop found the sample in a Massachusetts mine and sent it to the British Museum in London in 1734. The name columbium, which Hatchet named the new element, came from the poetic name for North America—Columbia—and was used interchangeably for niobium until 1949, when the name niobium became official. Swedish scientist Anders Ekberg discovered tantalum in 1802, but it was confused with niobium, because of their twinned properties, until 1864, when it was recognized as a separate element. Niobium is a lustrous, gray, ductile metal with a high melting point, relatively low density, and superconductor properties. Tantalum is a dark blue-gray, dense, ductile, very hard, and easily fabricated metal. It is highly conductive to heat and electricity and renowned for its resistance to acidic corrosion. These special properties determine their primary uses and make niobium and tantalum indispensable.

  9. NOTE: Modelling the influence of amnionicity on the severity of twin twin transfusion syndrome in monochorionic twin pregnancies

    NASA Astrophysics Data System (ADS)

    van den Wijngaard, Jeroen P. H. M.; Umur, Asli; Ross, Michael G.; van Gemert, Martin J. C.

    2004-03-01

    Clinical treatment for diamniotic monochorionic twin twin transfusion syndrome (TTTS) may include conversion of diamniotic pregnancies to a monoamniotic monochorionic state by disrupting the amnion septum. We sought to test the underlying hypothesis, i.e. that a monoamniotic state reduces the severity of TTTS. With use of our previously developed mathematical model of two equal fetoplacental circulatory units connected by various sizes and types of placental anastomoses, we compared the haemodynamic and amniotic fluid dynamics of monoamniotic and diamniotic twins that develop TTTS. We used three anastomotic patterns that produce severe, moderate or mild forms of TTTS, respectively, in our diamniotic monochorionic twin model. Monoamnionicity was modelled by adding the two amniotic fluid volumes and using the volume-averaged amniotic fluid osmolality. The results were as follows: for severe TTTS, small differences develop between diamniotic and monoamniotic donor twins in fetal urine production, swallowed volume, blood volume, blood pressures, net fetofetal transfusion, and blood and amniotic fluid osmolality. However, the circulatory imbalance between the monoamniotic twins deteriorates similar to that of diamniotic twins. The pathophysiological differences tend to disappear for milder TTTS. In conclusion, our model suggests that the uncommon finding of TTTS in monoamniotic twins is not due to the presence of a single amniotic sac. Rather, clinically significant differences in anastomotic patterns and the delayed or lack of identification of manifestations in monoamniotic twins account for the reduced rate of TTTS diagnosis. Based on these results we expect the clinical disruption of the amnion septum in diamniotic monochorionic TTTS pregnancies to have only minimal benefits.

  10. Aim for a Healthy Weight Maintaining a Healthy

    E-print Network

    Shen, Jun

    Aim for a Healthy Weight Maintaining a Healthy Weight On the Go A Pocket Guide #12;#12;Aim for a Healthy Weight Maintaining a Healthy Weight On the Go A Pocket Guide NIH Publication No. 10-7415 April on healthy choices will help you maintain a healthy weight. Why Is a Healthy Weight Important? Reaching

  11. NOTE: Thrombosis of anastomoses may affect the staging sequence of twin twin transfusion syndrome

    NASA Astrophysics Data System (ADS)

    van den Wijngaard, Jeroen P. H. M.; Ross, Michael G.; van Gemert, Martin J. C.

    2008-03-01

    Twin-twin transfusion syndrome (TTTS) is a severe complication of monozygotic (identical) twins, which share one single monochorionic placenta. It is caused by placental anastomoses which link the two fetoplacental circulations of the twins and allow a chronic net inter-twin transfusion to develop between the fetuses. Clinical presentation of TTTS manifestations has been classified into five different stages. In this paper, we used our computational model of TTTS and examined the possible differences between chronic and rapidly increasing inter-twin transfusion in the simulated TTTS staging sequence. Our results suggest that rapid alterations in the net inter-twin transfusion, e.g. due to thrombosis of placental anastomoses, may produce a different staging sequence than in TTTS caused by chronic inter-twin transfusion. These results may aid an improved knowledge of TTTS pathophysiology under conditions of a rapidly changing cardiovascular function, and contribute to the planning of optimal intervention under such circumstances. Supported in part by the European Community Euro-twin-2-twin project (JPHMvdW) and by the National Institutes of Health, grant HL40899 (MGR).

  12. Gut DNA viromes of Malawian twins discordant for severe acute malnutrition.

    PubMed

    Reyes, Alejandro; Blanton, Laura V; Cao, Song; Zhao, Guoyan; Manary, Mark; Trehan, Indi; Smith, Michelle I; Wang, David; Virgin, Herbert W; Rohwer, Forest; Gordon, Jeffrey I

    2015-09-22

    The bacterial component of the human gut microbiota undergoes a definable program of postnatal development. Evidence is accumulating that this program is disrupted in children with severe acute malnutrition (SAM) and that their persistent gut microbiota immaturity, which is not durably repaired with current ready-to-use therapeutic food (RUTF) interventions, is causally related to disease pathogenesis. To further characterize gut microbial community development in healthy versus malnourished infants/children, we performed a time-series metagenomic study of DNA isolated from virus-like particles (VLPs) recovered from fecal samples collected during the first 30 mo of postnatal life from eight pairs of mono- and dizygotic Malawian twins concordant for healthy growth and 12 twin pairs discordant for SAM. Both members of discordant pairs were sampled just before, during, and after treatment with a peanut-based RUTF. Using Random Forests and a dataset of 17,676 viral contigs assembled from shotgun sequencing reads of VLP DNAs, we identified viruses that distinguish different stages in the assembly of the gut microbiota in the concordant healthy twin pairs. This developmental program is impaired in both members of SAM discordant pairs and not repaired with RUTF. Phage plus members of the Anelloviridae and Circoviridae families of eukaryotic viruses discriminate discordant from concordant healthy pairs. These results disclose that apparently healthy cotwins in discordant pairs have viromes associated with, although not necessarily mediators, of SAM; as such, they provide a human model for delineating normal versus perturbed postnatal acquisition and retention of the gut microbiota's viral component in populations at risk for malnutrition. PMID:26351661

  13. Gut DNA viromes of Malawian twins discordant for severe acute malnutrition

    PubMed Central

    Reyes, Alejandro; Blanton, Laura V.; Cao, Song; Zhao, Guoyan; Manary, Mark; Trehan, Indi; Smith, Michelle I.; Wang, David; Virgin, Herbert W.; Rohwer, Forest; Gordon, Jeffrey I.

    2015-01-01

    The bacterial component of the human gut microbiota undergoes a definable program of postnatal development. Evidence is accumulating that this program is disrupted in children with severe acute malnutrition (SAM) and that their persistent gut microbiota immaturity, which is not durably repaired with current ready-to-use therapeutic food (RUTF) interventions, is causally related to disease pathogenesis. To further characterize gut microbial community development in healthy versus malnourished infants/children, we performed a time-series metagenomic study of DNA isolated from virus-like particles (VLPs) recovered from fecal samples collected during the first 30 mo of postnatal life from eight pairs of mono- and dizygotic Malawian twins concordant for healthy growth and 12 twin pairs discordant for SAM. Both members of discordant pairs were sampled just before, during, and after treatment with a peanut-based RUTF. Using Random Forests and a dataset of 17,676 viral contigs assembled from shotgun sequencing reads of VLP DNAs, we identified viruses that distinguish different stages in the assembly of the gut microbiota in the concordant healthy twin pairs. This developmental program is impaired in both members of SAM discordant pairs and not repaired with RUTF. Phage plus members of the Anelloviridae and Circoviridae families of eukaryotic viruses discriminate discordant from concordant healthy pairs. These results disclose that apparently healthy cotwins in discordant pairs have viromes associated with, although not necessarily mediators, of SAM; as such, they provide a human model for delineating normal versus perturbed postnatal acquisition and retention of the gut microbiota’s viral component in populations at risk for malnutrition. PMID:26351661

  14. Fragile X syndrome and the (CGG)n mutation: two families with discordant MZ twins.

    PubMed Central

    Kruyer, H.; Milà, M.; Glover, G.; Carbonell, P.; Ballesta, F.; Estivill, X.

    1994-01-01

    The fragile X phenotype has been found, in the majority of cases, to be due to the expansion of a CGG repeat in the 5'-UTR region of the FMR-1 gene, accompanied by methylation of the adjacent CpG island and inactivation of the FMR-1 gene. Although several important aspects of the genetics of fragile X have been resolved, it remains to be elucidated at which stage in development the transition from the premutation to the full mutation occurs. We present two families in which discordance between two sets of MZ twins illustrates two important genetic points. In one family, two affected MZ brothers differed in the number of CGG repeats, demonstrating in vivo mitotic instability of this CGG repeat and suggesting that the transition to the full mutation occurred postzygotically. In the second family, two MZ sisters had the same number of repeats, but only one was mentally retarded. When the methylation status of the FMR-1 CpG island was studied, we found that the majority of normal chromosomes had been inactivated in the affected twin, thus leading to the expression of the fragile X phenotype. Images Figure 1 Figure 2 PMID:8116613

  15. Gene Expression Profiles from Disease Discordant Twins Suggest Shared Antiviral Pathways and Viral Exposures among Multiple Systemic Autoimmune Diseases

    PubMed Central

    Gan, Lu; O’Hanlon, Terrance P.; Lai, Zhennan; Fannin, Rick; Weller, Melodie L.; Rider, Lisa G.; Chiorini, John A.; Miller, Frederick W.

    2015-01-01

    Viral agents are of interest as possible autoimmune triggers due to prior reported associations and widely studied molecular mechanisms of antiviral immune responses in autoimmunity. Here we examined new viral candidates for the initiation and/or promotion of systemic autoimmune diseases (SAID), as well as possible related signaling pathways shared in the pathogenesis of those disorders. RNA isolated from peripheral blood samples from 33 twins discordant for SAID and 33 matched, unrelated healthy controls was analyzed using a custom viral-human gene microarray. Paired comparisons were made among three study groups—probands with SAID, their unaffected twins, and matched, unrelated healthy controls—using statistical and molecular pathway analyses. Probands and unaffected twins differed significantly in the expression of 537 human genes, and 107 of those were associated with viral infections. These 537 differentially expressed human genes participate in overlapping networks of several canonical, biologic pathways relating to antiviral responses and inflammation. Moreover, certain viral genes were expressed at higher levels in probands compared to either unaffected twins or unrelated, healthy controls. Interestingly, viral gene expression levels in unaffected twins appeared intermediate between those of probands and the matched, unrelated healthy controls. Of the viruses with overexpressed viral genes, herpes simplex virus-2 (HSV-2) was the only human viral pathogen identified using four distinct oligonucleotide probes corresponding to three HSV-2 genes associated with different stages of viral infection. Although the effects from immunosuppressive therapy on viral gene expression remain unclear, this exploratory study suggests a new approach to evaluate shared viral agents and antiviral immune responses that may be involved in the development of SAID. PMID:26556803

  16. 156. Photocopy of written record (taken from Twin Falls Canal ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    156. Photocopy of written record (taken from Twin Falls Canal Company, Low Line Book #1, pp.2,3). LOW LINE CONTRACTORS AND BORROW RECORD. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  17. 159. Photocopy of written record (taken from Twin Falls Canal ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    159. Photocopy of written record (taken from Twin Falls Canal Company Low Line Book #1, pp. 76,77). RECORD OF BORROW AT LOW LINE SIPHON. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  18. Monozygotic twins with trisomy 18: a report of discordant phenotype.

    PubMed Central

    Schlessel, J S; Brown, W T; Lysikiewicz, A; Schiff, R; Zaslav, A L

    1990-01-01

    The predicted incidence of liveborn monozygotic trisomy 18 twins is one per million births. The first case of liveborn monozygotic trisomy 18 twins was reported in 1989 and we report a second case in which striking phenotypic discordance existed. The probability of monozygotic trisomy 18 twinning and the mechanisms for phenotypic discordance in trisomic twins is discussed. Images PMID:2246775

  19. 197. Photocopy of drawing, Twin Falls, Canal Company, date unknown. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    197. Photocopy of drawing, Twin Falls, Canal Company, date unknown. GATE STEMS AND LIFTING DEVICES, NO COUNTY; BLUEPRINT SKETCHES. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  20. TWIN BUILDING LATTICES DO NOT HAVE ASYMPTOTIC CUT-POINTS

    E-print Network

    Caprace, Pierre-Emmanuel

    TWIN BUILDING LATTICES DO NOT HAVE ASYMPTOTIC CUT-POINTS PIERRE-EMMANUEL CAPRACE*, FRANÇOIS DAHMANI**, AND VINCENT GUIRARDEL** Abstract. We show that twin building lattices have linear divergence, which implies of asymptotic cones of twin building lattices. Theorem 1. The asymptotic cones of a twin building lattice do

  1. Eating Healthy Ethnic Food

    MedlinePLUS

    ... Families ( We Can! ) Health Professional Resources Tipsheet: Eating Healthy Ethnic Food Trying different ethnic cuisines to give ... black beans Salsa or picante Soft corn tortillas Healthy Weight Tip Ask your server how the menu ...

  2. Germs and Staying Healthy

    MedlinePLUS

    ... Clinical Trial Living with CF Germs and Staying Healthy People living with CF are at greater risk ... More Topics Treatments and Therapies Germs and Staying Healthy Navigating Insurance CF and School Advocate CF Clinical ...

  3. Pregnancy and Healthy Weight

    MedlinePLUS

    ... Media Resources Interviews & Selected Staff Profiles Multimedia Pregnancy & Healthy Weight Skip sharing on social media links Share ... Page Content New research shows that maintaining a healthy weight before and during pregnancy can reduce the ...

  4. Twin and Triplet Drugs in Opioid Research

    NASA Astrophysics Data System (ADS)

    Fujii, Hideaki

    Twin and triplet drugs are defined as compounds that contain respectively two and three pharmacophore components exerting pharmacological effects in a molecule. The twin drug bearing the same pharmacophores is a "symmetrical twin drug", whereas that possessing different pharmacophores is a "nonsymmetrical twin drug." In general, the symmetrical twin drug is expected to produce more potent and/or selective pharmacological effects, whereas the nonsymmetrical twin drug is anticipated to show both pharmacological activities stemming from the individual pharmacophores (dual action). On the other hand, nonsymmetrical triplet drugs, which have two of the same pharmacophores and one different moiety, are expected to elicit both increased pharmacological action and dual action. The two identical portions could bind the same receptor sites simultaneously while the third portion could bind a different receptor site or enzyme. This review will mainly focus on the twin and triplet drugs with an evaluation of their in vivo pharmacological effects, and will also include a description of their pharmacology and synthesis.

  5. The Mid-Atlantic Twin Registry.

    PubMed

    Anderson, Lisa S; Beverly, William T; Corey, Linda A; Murrelle, Lenn

    2002-10-01

    The Mid-Atlantic Twin Registry (MATR) is a population-based registry of twin pairs ascertained from birth records and school system records of Virginia, North Carolina, and South Carolina. The MATR was formed in 1997 with the merging of the Virginia and North Carolina Twin Registries, and it expanded to include South Carolina when access to twin birth records in that state was granted in 1998. Registered twins ("participants") number more than 51,000, with approximately 46,000 of these individuals representing complete pairs. Roughly two-thirds of MATR participants are over age 18, with a mean age of approximately 35 years. These participants have primarily been drawn from the more than 170,000 identical and fraternal twin pairs born in the three states between 1913 and 2000. Twins and their family members have participated in numerous research projects, ranging from general health surveys to studies on specific health topics such as cardiovascular disease; depression and anxiety; seizures; behavioral development; pregnancy complications; conduct disorder; drug use, abuse, and dependence; cleft lip/palate; obesity; and chronic fatigue syndrome. The MATR has established a privacy policy and strict standard operating procedures to protect the confidentiality of participant data. The MATR considers a limited number of qualified requests per year from investigators interested in recruiting MATR participants into their research studies. PMID:12537875

  6. Hypothesis test for synchronization: Twin surrogates revisited

    NASA Astrophysics Data System (ADS)

    Romano, M. Carmen; Thiel, Marco; Kurths, Jürgen; Mergenthaler, Konstantin; Engbert, Ralf

    2009-03-01

    The method of twin surrogates has been introduced to test for phase synchronization of complex systems in the case of passive experiments. In this paper we derive new analytical expressions for the number of twins depending on the size of the neighborhood, as well as on the length of the trajectory. This allows us to determine the optimal parameters for the generation of twin surrogates. Furthermore, we determine the quality of the twin surrogates with respect to several linear and nonlinear statistics depending on the parameters of the method. In the second part of the paper we perform a hypothesis test for phase synchronization in the case of experimental data from fixational eye movements. These miniature eye movements have been shown to play a central role in neural information processing underlying the perception of static visual scenes. The high number of data sets (21 subjects and 30 trials per person) allows us to compare the generated twin surrogates with the "natural" surrogates that correspond to the different trials. We show that the generated twin surrogates reproduce very well all linear and nonlinear characteristics of the underlying experimental system. The synchronization analysis of fixational eye movements by means of twin surrogates reveals that the synchronization between the left and right eye is significant, indicating that either the centers in the brain stem generating fixational eye movements are closely linked, or, alternatively that there is only one center controlling both eyes.

  7. The Numbers of Intramammary Infections and Teat Duct Colonizations in a Herd of Twins During a Hygiene Experiment

    PubMed Central

    Newbould, F. H. S.; Carey, P. G.; Barnum, D. A.

    1970-01-01

    An experiment originally employing ten pairs of twin heifers was carried out to assess the long-term effect of a complete hygiene regimen designed to protect the mammary gland from infection. As long as they remained in the experiment, one member of each twin pair was milked under a complete hygiene system while her sister was milked with no hygiene at all. Significantly more intramammary infections occurred in the controls (no hygiene) than in the hygiene cows. Very significantly more teat ducts became colonized by bacteria in the controls than in the hygiene cows, and significantly more of these developed into intramammary infections in the controls. Thus, hygiene effectively controlled both bacterial colonization of teat ducts and intramammary infections during lactation, but this control was to some extent offset by infections which took place during the dry period and at calving. There appeared to be a relationship between susceptibility to teat duct colonization and medical conditions other than mammary gland infections in six pairs of twins which had to be discarded before the third lactation. PMID:4248441

  8. Identifying possible sister groups of Cryptocercidae+Isoptera: a combined molecular and morphological phylogeny of Dictyoptera.

    PubMed

    Djernæs, Marie; Klass, Klaus-Dieter; Eggleton, Paul

    2015-03-01

    Termites (Isoptera) offer an alternative model for the development of eusociality which is not dependent on a high degree of relatedness as found between sisters in hymenopterans (bees, wasps, ants). Recent phylogenetic studies have established that termites belong within the cockroaches as sister to the subsocial Cryptocercidae. Cryptocercidae shares several important traits with termites, thus we need to understand the phylogenetic position of Cryptocercidae+Isoptera to determine how these traits evolved. However, placement of Cryptocercidae+Isoptera is still uncertain. We used both molecular (12S, 16S, COII, 18S, 28S, H3) and morphological characters to reconstruct the phylogeny of Dictyoptera. We included all previously suggested sister groups of Cryptocercidae+Isoptera as well as taxa which might represent additional major cockroach lineages. We used Bayes factors to test different sister groups for Cryptocercidae+Isoptera and assessed character support for the consensus tree based on morphological characters and COII amino acid data. We used the molecular data and fossil calibration to estimate divergence times. We found the most likely sister groups of Cryptocercidae+Isoptera to be Tryonicidae, Anaplecta or Tryonicidae+Anaplecta. Anaplecta has never previously been suggested as sister group or even close to Cryptocercidae+Isoptera, but was formerly placed in Blaberoidea as sister to the remaining taxa. Topological tests firmly supported our new placement of Anaplecta. We discuss the morphological characters (e.g. retractable genitalic hook) that have contributed to the previous placement of Anaplecta in Blaberoidea as well as the factors that might have contributed to a parallel development of genitalic features in Anaplecta and Blaberoidea. Cryptocercidae+Isoptera is placed in a clade with Tryonicidae, Anaplecta and possibly Lamproblattidae. Based on this, we suggest that wood-feeding, and the resultant need to conserve nitrogen, may have been an important factor in the development of termite eusociality. Nocticolidae was placed as sister group to Latindia+Paralatindia (both Corydiidae), this clade was in turn placed as sister group to the remaining Corydiidae. The Nocticolidae+Corydiidae clade is supported by both morphological and COII amino acid changes. Our divergence time estimates placed the split between Mantodea and Blattodea at 273mya (middle Permian) and the splits between the major blattodean lineages no later than 200mya (end of Triassic). PMID:25194324

  9. Sister cohesion and structural axis components mediate homolog bias of meiotic recombination

    PubMed Central

    Kim, Keun P.; Weiner, Beth M.; Zhang, Liangran; Jordan, Amy; Dekker, Job; Kleckner, Nancy

    2010-01-01

    SUMMARY Meiotic recombination occurs between one chromatid of each maternal and paternal homolog (homolog bias) versus between sister chromatids (sister bias). Physical DNA analysis reveals that meiotic cohesin/axis component Rec8 promotes sister bias, likely via its cohesion activity. Two meiosis-specific axis components, Red1/Mek1kinase, counteract this effect. With this precondition satisfied, other molecules directly specify homolog bias per se. Rec8 also acts positively to maintain homolog bias during crossover recombination. These observations point to sequential release of double-strand break ends from association with their sister. Red1 and Rec8 are found to play distinct roles for sister cohesion, DSB formation and recombination progression kinetics. Also, the two components are enriched in spatially distinct domains of axial structure that develop prior to DSB formation. We propose that Red1 and Rec8 domains provide functionally complementary environments whereby inputs evolved from DSB repair and late-stage chromosome morphogenesis are integrated to give the complete meiotic chromosomal program. PMID:21145459

  10. Drosophila separase is required for sister chromatid separation and binds to PIM and THR.

    PubMed

    Jäger, H; Herzig, A; Lehner, C F; Heidmann, S

    2001-10-01

    Drosophila PIM and THR are required for sister chromatid separation in mitosis and associate in vivo. Neither of these two proteins shares significant sequence similarity with known proteins. However, PIM has functional similarities with securin proteins. Like securin, PIM is degraded at the metaphase-to-anaphase transition and this degradation is required for sister chromatid separation. Securin binds and inhibits separase, a conserved cysteine endoprotease. Proteolysis of securin at the metaphase-to-anaphase transition activates separase, which degrades a conserved cohesin subunit, thereby allowing sister chromatid separation. To address whether PIM regulates separase activity or functions with THR in a distinct pathway, we have characterized a Drosophila separase homolog (SSE). SSE is an unusual member of the separase family. SSE is only about one-third the size of other separases and has a diverged endoprotease domain. However, our genetic analyses show that SSE is essential and required for sister chromatid separation during mitosis. Moreover, we show that SSE associates with both PIM and THR. Although our work shows that separase is required for sister chromatid separation in higher eukaryotes, in addition, it also indicates that the regulatory proteins have diverged to a surprising degree, particularly in Drosophila. PMID:11581162

  11. Drosophila Separase is required for sister chromatid separation and binds to PIM and THR

    PubMed Central

    Jäger, Hubert; Herzig, Alf; Lehner, Christian F.; Heidmann, Stefan

    2001-01-01

    Drosophila PIM and THR are required for sister chromatid separation in mitosis and associate in vivo. Neither of these two proteins shares significant sequence similarity with known proteins. However, PIM has functional similarities with securin proteins. Like securin, PIM is degraded at the metaphase-to-anaphase transition and this degradation is required for sister chromatid separation. Securin binds and inhibits separase, a conserved cysteine endoprotease. Proteolysis of securin at the metaphase-to-anaphase transition activates separase, which degrades a conserved cohesin subunit, thereby allowing sister chromatid separation. To address whether PIM regulates separase activity or functions with THR in a distinct pathway, we have characterized a Drosophila separase homolog (SSE). SSE is an unusual member of the separase family. SSE is only about one-third the size of other separases and has a diverged endoprotease domain. However, our genetic analyses show that SSE is essential and required for sister chromatid separation during mitosis. Moreover, we show that SSE associates with both PIM and THR. Although our work shows that separase is required for sister chromatid separation in higher eukaryotes, in addition, it also indicates that the regulatory proteins have diverged to a surprising degree, particularly in Drosophila. PMID:11581162

  12. Mechanics of Sister Chromatids studied with a Polymer Model English</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Zhang, Yang; Isbaner, Sebastian; Heermann, Dieter</p> <p>2013-10-01</p> <p><span class="hlt">Sister</span> chromatid cohesion denotes the phenomenon that <span class="hlt">sister</span> chromatids are initially attached to each other in mitosis to guarantee the error-free distribution into the daughter cells. Cohesion is mediated by binding proteins and only resolved after mitotic chromosome condensation is completed. However, the amount of attachement points required to maintain <span class="hlt">sister</span> chromatid cohesion while still allowing proper chromosome condensation is not known yet. Additionally the impact of cohesion on the mechanical properties of chromosomes also poses an interesting problem. In this work we study the conformational and mechanical properties of <span class="hlt">sister</span> chromatids by means of computer simulations. We model both protein-mediated cohesion between <span class="hlt">sister</span> chromatids and chromosome condensation with a dynamic binding mechanisms. We show in a phase diagram that only specific link concentrations lead to connected and fully condensed chromatids that do not intermingle with each other nor separate due to entropic forces. Furthermore we show that dynamic bonding between chromatids decrease the Young's modulus compared to non-bonded chromatids.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4224182','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4224182"><span id="translatedtitle"><span class="hlt">Sisters</span> Unbound Is Required for Meiotic Centromeric Cohesion in Drosophila melanogaster</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Krishnan, Badri; Thomas, Sharon E.; Yan, Rihui; Yamada, Hirotsugu; Zhulin, Igor B.; McKee, Bruce D.</p> <p>2014-01-01</p> <p>Regular meiotic chromosome segregation requires <span class="hlt">sister</span> centromeres to mono-orient (orient to the same pole) during the first meiotic division (meiosis I) when homologous chromosomes segregate, and to bi-orient (orient to opposite poles) during the second meiotic division (meiosis II) when <span class="hlt">sister</span> chromatids segregate. Both orientation patterns require cohesion between <span class="hlt">sister</span> centromeres, which is established during meiotic DNA replication and persists until anaphase of meiosis II. Meiotic cohesion is mediated by a conserved four-protein complex called cohesin that includes two structural maintenance of chromosomes (SMC) subunits (SMC1 and SMC3) and two non-SMC subunits. In Drosophila melanogaster, however, the meiotic cohesion apparatus has not been fully characterized and the non-SMC subunits have not been identified. We have identified a novel Drosophila gene called <span class="hlt">sisters</span> unbound (sunn), which is required for stable <span class="hlt">sister</span> chromatid cohesion throughout meiosis. sunn mutations disrupt centromere cohesion during prophase I and cause high frequencies of non-disjunction (NDJ) at both meiotic divisions in both sexes. SUNN co-localizes at centromeres with the cohesion proteins SMC1 and SOLO in both sexes and is necessary for the recruitment of both proteins to centromeres. Although SUNN lacks sequence homology to cohesins, bioinformatic analysis indicates that SUNN may be a structural homolog of the non-SMC cohesin subunit stromalin (SA), suggesting that SUNN may serve as a meiosis-specific cohesin subunit. In conclusion, our data show that SUNN is an essential meiosis-specific Drosophila cohesion protein. PMID:25194162</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/25194162','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/25194162"><span id="translatedtitle"><span class="hlt">Sisters</span> unbound is required for meiotic centromeric cohesion in Drosophila melanogaster.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Krishnan, Badri; Thomas, Sharon E; Yan, Rihui; Yamada, Hirotsugu; Zhulin, Igor B; McKee, Bruce D</p> <p>2014-11-01</p> <p>Regular meiotic chromosome segregation requires <span class="hlt">sister</span> centromeres to mono-orient (orient to the same pole) during the first meiotic division (meiosis I) when homologous chromosomes segregate, and to bi-orient (orient to opposite poles) during the second meiotic division (meiosis II) when <span class="hlt">sister</span> chromatids segregate. Both orientation patterns require cohesion between <span class="hlt">sister</span> centromeres, which is established during meiotic DNA replication and persists until anaphase of meiosis II. Meiotic cohesion is mediated by a conserved four-protein complex called cohesin that includes two structural maintenance of chromosomes (SMC) subunits (SMC1 and SMC3) and two non-SMC subunits. In Drosophila melanogaster, however, the meiotic cohesion apparatus has not been fully characterized and the non-SMC subunits have not been identified. We have identified a novel Drosophila gene called <span class="hlt">sisters</span> unbound (sunn), which is required for stable <span class="hlt">sister</span> chromatid cohesion throughout meiosis. sunn mutations disrupt centromere cohesion during prophase I and cause high frequencies of non-disjunction (NDJ) at both meiotic divisions in both sexes. SUNN co-localizes at centromeres with the cohesion proteins SMC1 and SOLO in both sexes and is necessary for the recruitment of both proteins to centromeres. Although SUNN lacks sequence homology to cohesins, bioinformatic analysis indicates that SUNN may be a structural homolog of the non-SMC cohesin subunit stromalin (SA), suggesting that SUNN may serve as a meiosis-specific cohesin subunit. In conclusion, our data show that SUNN is an essential meiosis-specific Drosophila cohesion protein. PMID:25194162</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1626985','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1626985"><span id="translatedtitle">Infantile spasms syndrome in monozygotic <span class="hlt">twins</span>.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Pavone, L; Mollica, F; Incorpora, G; Pampiglione, G</p> <p>1980-01-01</p> <p>The infantile spasms syndrome appeared on the same day in a pair of monozygotic <span class="hlt">twins</span> at age 6 months. Clinical, electroencephalographic, and neuroradiological findings during the development of the disease are reported. One of the <span class="hlt">twins</span> was treated with ACTH and in his case clinical and electroencephalographic improvement was more rapid than in the other who was treated with clonazepam. While the computer tomography scan initially showed in each <span class="hlt">twin</span> an area of low density in the right fronto-parietal region, this had disappeared in the tomograms obtained about 8 months later. PMID:6254446</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/18465811','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/18465811"><span id="translatedtitle">Spontaneous unilateral dizygotic <span class="hlt">twin</span> tubal pregnancy.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Tam, Teresa; Khazaei, Ali</p> <p>2009-02-01</p> <p>Spontaneous dizygotic unilateral <span class="hlt">twin</span> tubal pregnancy is an extremely rare occurrence with a high risk for pregnancy-related mortality, and a diagnostic challenge for obstetricians. We present a case of a 27-year-old woman with spontaneous <span class="hlt">twin</span> tubal pregnancy. Transvaginal color Doppler sonography revealed 2 separate gestational sacs within the right adnexa, each containing an embryo. Cytogenetic examination of the trophoblastic tissues confirmed the diagnosis of dizygotic <span class="hlt">twin</span> ectopic pregnancy. Clinical signs and symptoms together with imaging studies help in the diagnosis of this rare variant of ectopic pregnancies. PMID:18465811</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/servlets/purl/960552','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/servlets/purl/960552"><span id="translatedtitle">Nanoscale growth <span class="hlt">twins</span> in sputtered metal films</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Misra, Amit; Anderoglu, Osman; Hoagland, Richard G; Zhang, X</p> <p>2008-01-01</p> <p>We review recent studies on the mechanical properties of sputtered Cu and 330 stainless steel films with {l_brace}1 1 1{r_brace} nanoscale growth <span class="hlt">twins</span> preferentially oriented perpendicular to growth direction. The mechanisms of formation of growth <span class="hlt">twins</span> during sputtering and the deformation mechanisms that enable usually high strengths in nanotwinned structures are highlighted. Growth <span class="hlt">twins</span> in sputtered films possess good thermal stability at elevated temperature, providing an approach to extend the application of high strength nanostructured metals to higher temperatures.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2001AmJPh..69.1257D','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2001AmJPh..69.1257D"><span id="translatedtitle">On radar time and the <span class="hlt">twin</span> ``paradox''</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Dolby, Carl E.; Gull, Stephen F.</p> <p>2001-12-01</p> <p>In this paper we apply the concept of radar time (popularized by Bondi in his work on k calculus) to the well-known relativistic <span class="hlt">twin</span> "paradox." Radar time is used to define hypersurfaces of simultaneity for a class of traveling <span class="hlt">twins</span>, from the "immediate turn-around" case, through the "gradual turn-around" case, to the "uniformly accelerating" case. We show that this definition of simultaneity is independent of choice of coordinates, and assigns a unique time to any event (with which the traveling <span class="hlt">twin</span> can send and receive signals), resolving some common misconceptions.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/16983157','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/16983157"><span id="translatedtitle">Specific <span class="hlt">twin</span> junctions in doped zirconia.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Morales, F M; Rühle, M</p> <p>2006-10-01</p> <p>The effect of different dopant cations on the phase transformations of the initially stabilized supersaturated tetragonal ZrO(2) phase during various heat treatments has been studied. The obtained fraction of monoclinic grains develop <span class="hlt">twinned</span> structures, but there is still a lack of information about the character of grain boundaries formed in doped monoclinic solid solutions. The inspection of particular selected-area electron diffraction patterns provides an alternative method with respect to high-resolution electron microscopy or electron back-scattered diffraction for characterizing different <span class="hlt">twin</span> junctions in various doped zirconia systems. The classification of these special <span class="hlt">twins</span> is based on the coincidence site lattice concept. PMID:16983157</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2005ApPhL..86j1915W','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2005ApPhL..86j1915W"><span id="translatedtitle">Deformation <span class="hlt">twinning</span> during nanoindentation of nanocrystalline Ta</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Wang, Y. M.; Hodge, A. M.; Biener, J.; Hamza, A. V.; Barnes, D. E.; Liu, Kai; Nieh, T. G.</p> <p>2005-03-01</p> <p>The deformation mechanism of body-centered cubic (bcc) nanocrystalline tantalum with grain sizes of 10-30 nm is investigated by nanoindentation, scanning electron microscopy and high-resolution transmission electron microscopy. In a deviation from molecular dynamics simulations and existing experimental observations on other bcc nanocrystalline metals, the plastic deformation of nanocrystalline Ta during nanoindentation is controlled by deformation <span class="hlt">twinning</span>. The observation of multiple <span class="hlt">twin</span> intersections suggests that the physical mechanism of deformation <span class="hlt">twinning</span> in bcc nanocrystalline materials is different from that in face-centered cubic (fcc) nanocrystalline metals.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_13");'>13</a></li> <li><a href="#" onclick='return showDiv("page_14");'>14</a></li> <li class="active"><span>15</span></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_15 --> <div id="page_16" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_14");'>14</a></li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li class="active"><span>16</span></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="301"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/12596123','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/12596123"><span id="translatedtitle">Atypical parasitic ischiopagus conjoined <span class="hlt">twins</span>.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Corona-Rivera, J Román; Corona-Rivera, Enrique; Franco-Topete, Ramón; Acosta-León, Jorge; Aguila-Dueñas, Virginia; Corona-Rivera, Alfredo</p> <p>2003-02-01</p> <p>Occurrence of asymmetrical or parasitic conjoined <span class="hlt">twins</span> (CT) is rare, and currently they are classified analogically to the common unions of symmetrical CT. The authors report on an infant with a parasitic third limb attached to the left lateral aspect of the autosite trunk, in whom male gonadal tissue was found histologically. Parasite parts included complete left lower limb, hemipelvis, lumbosacral vertebral column, spinal cord, and one kidney with ureter and adrenal gland. Autosite anomalies comprised a small left diaphragmatic defect, omphalocele, exstrophy of cloaca, and lumbar meningomyelocele. The authors considered this case to be a rare atypical parasitic ischiopagus CT. The differential diagnosis of the type of twining and other entities with caudal duplications is analyzed briefly. PMID:12596123</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/23385371','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/23385371"><span id="translatedtitle">Bellagio report on <span class="hlt">healthy</span> agriculture, <span class="hlt">healthy</span> nutrition, <span class="hlt">healthy</span> people.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Simopoulos, Artemis P; Bourne, Peter G; Faergeman, Ole</p> <p>2013-02-01</p> <p>The Bellagio Report on <span class="hlt">Healthy</span> Agriculture, <span class="hlt">Healthy</span> Nutrition, <span class="hlt">Healthy</span> People is the result of the meeting held at the Rockefeller Foundation Bellagio Center in Lake Como, Italy, 29 October-2 November 2012. The meeting was science-based but policy-oriented. The role and amount of <span class="hlt">healthy</span> and unhealthy fats, with attention to the relative content of omega-3 and omega-6 fatty acids, sugar, and particularly fructose in foods that may underlie the epidemics of non-communicable diseases (NCD's) worldwide were extensively discussed. The report concludes that sugar consumption, especially in the form of high energy fructose in soft drinks, poses a major and insidious health threat, especially in children, and most diets, although with regional differences, are deficient in omega-3 fatty acids and too high in omega-6 fatty acids. Gene-nutrient interactions in growth and development and in disease prevention are fundamental to health, therefore regional Centers on Genetics, Nutrition and Fitness for Health should be established worldwide. Heads of state and government must elevate, as a matter of urgency, Nutrition as a national priority, that access to a <span class="hlt">healthy</span> diet should be considered a human right and that the lead responsibility for Nutrition should be placed in Ministries of Health rather than agriculture so that the health requirements drive agricultural priorities, not vice versa. Nutritional security should be given the same priority as food security. PMID:23385371</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3635202','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3635202"><span id="translatedtitle">Bellagio Report on <span class="hlt">Healthy</span> Agriculture, <span class="hlt">Healthy</span> Nutrition, <span class="hlt">Healthy</span> People</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Simopoulos, Artemis P.; Bourne, Peter G.; Faergeman, Ole</p> <p>2013-01-01</p> <p>The Bellagio Report on <span class="hlt">Healthy</span> Agriculture, <span class="hlt">Healthy</span> Nutrition, <span class="hlt">Healthy</span> People is the result of the meeting held at the Rockefeller Foundation Bellagio Center in Lake Como, Italy, 29 October–2 November 2012. The meeting was science-based but policy-oriented. The role and amount of <span class="hlt">healthy</span> and unhealthy fats, with attention to the relative content of omega-3 and omega-6 fatty acids, sugar, and particularly fructose in foods that may underlie the epidemics of non-communicable diseases (NCD’s) worldwide were extensively discussed. The report concludes that sugar consumption, especially in the form of high energy fructose in soft drinks, poses a major and insidious health threat, especially in children, and most diets, although with regional differences, are deficient in omega-3 fatty acids and too high in omega-6 fatty acids. Gene-nutrient interactions in growth and development and in disease prevention are fundamental to health, therefore regional Centers on Genetics, Nutrition and Fitness for Health should be established worldwide. Heads of state and government must elevate, as a matter of urgency, Nutrition as a national priority, that access to a <span class="hlt">healthy</span> diet should be considered a human right and that the lead responsibility for Nutrition should be placed in Ministries of Health rather than agriculture so that the health requirements drive agricultural priorities, not vice versa. Nutritional security should be given the same priority as food security. PMID:23385371</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/24852698','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/24852698"><span id="translatedtitle">Assessment of genotoxicity associated with Behcet's disease using <span class="hlt">sister</span>-chromatid exchange assay: vitamin E versus mitomycin C.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Khabour, Omar F; Alawneh, Khaldon; Al-Kofahi, Etizaz; Mesmar, Fahmee</p> <p>2015-12-01</p> <p>Behcet's disease (BD) is a multisystemic chronic inflammatory disorder that presents throughout the world with high frequency in Turkey and Middle East. BD has been shown to be associated with genotoxicity as patients with the disease have demonstrated high rates of <span class="hlt">sister</span> chromatid exchange (SCE) and oxidative DNA damage. In this study, we examined the effect of vitamin E, which is known for its strong antioxidant activity, on the rate of SCE in cultured lymphocytes obtained from BD patients. In addition, the susceptibility of patient lymphocytes to the mutagenic agent mitomycin C (MMC) was also investigated. The results showed significant elevation in the rate of SCE in lymphocytes obtained from patients compared to those from <span class="hlt">healthy</span> subjects (P < 0.01). Treatment with vitamin E normalized the elevated rate of SCE to a comparable level observed in the control group (P < 0.01). Finally, treatment of cultures with MMC significantly increased the rate of SCE in the lymphocytes of both patients and controls (P < 0.001). The magnitude of change in the rate of SCE induced by MMC was equivalent in both groups. This result suggests similar sensitivity of BD lymphocytes and control ones to MMC. In conclusion, genotoxicity associated with BD can be overcome by treatment with vitamin E. Lymphocytes of BD have normal sensitivity to the mutagenic agent MMC. PMID:24852698</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2063729','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2063729"><span id="translatedtitle">Separase: a universal trigger for <span class="hlt">sister</span> chromatid disjunction but not chromosome cycle progression</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Wirth, Karin G.; Wutz, Gordana; Kudo, Nobuaki R.; Desdouets, Chantal; Zetterberg, Anders; Taghybeeglu, Shahryar; Seznec, Janina; Ducos, Germain M.; Ricci, Romeo; Firnberg, Nicole; Peters, Jan-Michael; Nasmyth, Kim</p> <p>2006-01-01</p> <p>Separase is a protease whose liberation from its inhibitory chaperone Securin triggers <span class="hlt">sister</span> chromatid disjunction at anaphase onset in yeast by cleaving cohesin's kleisin subunit. We have created conditional knockout alleles of the mouse Separase and Securin genes. Deletion of both copies of Separase but not Securin causes embryonic lethality. Loss of Securin reduces Separase activity because deletion of just one copy of the Separase gene is lethal to embryos lacking Securin. In embryonic fibroblasts, Separase depletion blocks <span class="hlt">sister</span> chromatid separation but does not prevent other aspects of mitosis, cytokinesis, or chromosome replication. Thus, fibroblasts lacking Separase become highly polyploid. Hepatocytes stimulated to proliferate in vivo by hepatectomy also become unusually large and polyploid in the absence of Separase but are able to regenerate functional livers. Separase depletion in bone marrow causes aplasia and the presumed death of hematopoietic cells other than erythrocytes. Destruction of <span class="hlt">sister</span> chromatid cohesion by Separase may be a universal feature of mitosis in eukaryotic cells. PMID:16533945</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3368859','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3368859"><span id="translatedtitle">Sororin is a master regulator of <span class="hlt">sister</span> chromatid cohesion and separation</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Zhang, Nenggang; Pati, Debananda</p> <p>2012-01-01</p> <p>The maintenance of <span class="hlt">sister</span> chromatid cohesion from S phase to the onset of anaphase relies on a small but evolutionarily conserved protein called Sororin. Sororin is a phosphoprotein and its dynamic localization and function are regulated by protein kinases, such as Cdk1/cyclin B and Erk2. The association of Sororin with chromatin requires cohesin to be preloaded to chromatin and modification of Smc3 during DNA replication. Sororin antagonizes the function of Wapl in cohesin releasing from S to G2 phase and promotes cohesin release from <span class="hlt">sister</span> chromatid arms in prophase via interaction with Plk1. This review focuses on progress of the identification and regulation of Sororin during cell cycle; role of post-translational modification on Sororin function; role of Sororin in the maintenance and resolution of <span class="hlt">sister</span> chromatid cohesion; and finally discusses Sororin’s emerging role in cancer and the potential issues that need be addressed in the future. PMID:22580470</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/24846387','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/24846387"><span id="translatedtitle">Metabolome and fecal microbiota in monozygotic <span class="hlt">twin</span> pairs discordant for weight: a Big Mac challenge.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Bondia-Pons, Isabel; Maukonen, Johanna; Mattila, Ismo; Rissanen, Aila; Saarela, Maria; Kaprio, Jaakko; Hakkarainen, Antti; Lundbom, Jesper; Lundbom, Nina; Hyötyläinen, Tuulia; Pietiläinen, Kirsi H; Oreši?, Matej</p> <p>2014-09-01</p> <p>Postprandial responses to food are complex, involving both genetic and environmental factors. We studied postprandial responses to a Big Mac meal challenge in monozygotic co-<span class="hlt">twins</span> highly discordant for body weight. This unique design allows assessment of the contribution of obesity, independent of genetic liability. Comprehensive metabolic profiling using 3 analytical platforms was applied to fasting and postprandial serum samples from 16 <span class="hlt">healthy</span> monozygotic <span class="hlt">twin</span> pairs discordant for weight (body mass index difference >3 kg/m(2)). Nine concordant monozygotic pairs were examined as control pairs. Fecal samples were analyzed to assess diversity of the major bacterial groups by using 5 different validated bacterial group specific denaturing gradient gel electrophoresis methods. No differences in fecal bacterial diversity were detected when comparing co-<span class="hlt">twins</span> discordant for weight (ANOVA, P<0.05). We found that within-pair similarity is a dominant factor in the metabolic postprandial response, independent of acquired obesity. Branched chain amino acids were increased in heavier as compared with leaner co-<span class="hlt">twins</span> in the fasting state, but their levels converged postprandially (paired t tests, FDR q<0.05). We also found that specific bacterial groups were associated with postprandial changes of specific metabolites. Our findings underline important roles of genetic and early life factors in the regulation of postprandial metabolite levels. PMID:24846387</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2279116','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2279116"><span id="translatedtitle">Single mitochondrial gene barcodes reliably identify <span class="hlt">sister</span>-species in diverse clades of birds</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p></p> <p>2008-01-01</p> <p>Background DNA barcoding of life using a standardized COI sequence was proposed as a species identification system, and as a method for detecting putative new species. Previous tests in birds showed that individuals can be correctly assigned to species in ~94% of the cases and suggested a threshold of 10× mean intraspecific difference to detect potential new species. However, these tests were criticized because they were based on a single maternally inherited gene rather than multiple nuclear genes, did not compare phylogenetically identified <span class="hlt">sister</span> species, and thus likely overestimated the efficacy of DNA barcodes in identifying species. Results To test the efficacy of DNA barcodes we compared ~650 bp of COI in 60 <span class="hlt">sister</span>-species pairs identified in multigene phylogenies from 10 orders of birds. In all pairs, individuals of each species were monophyletic in a neighbor-joining (NJ) tree, and each species possessed fixed mutational differences distinguishing them from their <span class="hlt">sister</span> species. Consequently, individuals were correctly assigned to species using a statistical coalescent framework. A coalescent test of taxonomic distinctiveness based on chance occurrence of reciprocal monophyly in two lineages was verified in known <span class="hlt">sister</span> species, and used to identify recently separated lineages that represent putative species. This approach avoids the use of a universal distance cutoff which is invalidated by variation in times to common ancestry of <span class="hlt">sister</span> species and in rates of evolution. Conclusion Closely related <span class="hlt">sister</span> species of birds can be identified reliably by barcodes of fixed diagnostic substitutions in COI sequences, verifying coalescent-based statistical tests of reciprocal monophyly for taxonomic distinctiveness. Contrary to recent criticisms, a single DNA barcode is a rapid way to discover monophyletic lineages within a metapopulation that might represent undiscovered cryptic species, as envisaged in the unified species concept. This identifies a smaller set of lineages that can also be tested independently for species status with multiple nuclear gene approaches and other phenotypic characters. PMID:18328107</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/biblio/22275800','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/biblio/22275800"><span id="translatedtitle">Asymmetric <span class="hlt">twins</span> in rhombohedral boron carbide</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Fujita, Takeshi Guan, Pengfei; Madhav Reddy, K.; Hirata, Akihiko; Guo, Junjie; Chen, Mingwei</p> <p>2014-01-13</p> <p>Superhard materials consisting of light elements have recently received considerable attention because of their ultrahigh specific strength for a wide range of applications as structural and functional materials. However, the failure mechanisms of these materials subjected to high stresses and dynamic loading remain to be poorly known. We report asymmetric <span class="hlt">twins</span> in a complex compound, boron carbide (B{sub 4}C), characterized by spherical-aberration-corrected transmission electron microscopy. The atomic structure of boron-rich icosahedra at rhombohedral vertices and cross-linked carbon-rich atomic chains can be clearly visualized, which reveals unusual asymmetric <span class="hlt">twins</span> with detectable strains along the <span class="hlt">twin</span> interfaces. This study offers atomic insights into the structure of <span class="hlt">twins</span> in a complex material and has important implications in understanding the planar defect-related failure of superhard materials under high stresses and shock loading.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://kidshealth.org/kid/feeling/home_family/twin_triplet.html','NIH-MEDLINEPLUS'); return false;" href="http://kidshealth.org/kid/feeling/home_family/twin_triplet.html"><span id="translatedtitle">When You Are a <span class="hlt">Twin</span> or Triplet</span></a></p> <p><a target="_blank" href="http://medlineplus.gov/">MedlinePLUS</a></p> <p></p> <p></p> <p>... People, Places & Things That Help Feelings Q&A Movies & More Quizzes Games Kids' Medical Dictionary En Español ... the same parents. They can even be different sexes. Being a <span class="hlt">twin</span> doesn't mean you have ...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://oaktrust.library.tamu.edu//handle/1969.1/149281','EPRINT'); return false;" href="http://oaktrust.library.tamu.edu//handle/1969.1/149281"><span id="translatedtitle">Rotordynamics of <span class="hlt">Twin</span>-Screw Pumps </span></a></p> <p><a target="_blank" href="http://www.osti.gov/eprints/">E-print Network</a></p> <p>Aboel Hassan Muhammed, Ameen</p> <p>2013-02-26</p> <p><span class="hlt">Twin</span>-screw pumps are positive displacement machines. Two meshing screws connected by timing gears convey the fluid trapped in the screw chambers axially from suction to discharge and force it out against the back pressure. Because of the screw...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/2761906','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/2761906"><span id="translatedtitle"><span class="hlt">Twin</span> gestations: I. Antenatal care and complications.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Kovacs, B W; Kirschbaum, T H; Paul, R H</p> <p>1989-09-01</p> <p>In order to determine the occurrence of antenatal complications in <span class="hlt">twin</span> pregnancies, we examined the medical records of 939 consecutive <span class="hlt">twin</span> gestations delivered at Women's Hospital, Los Angeles County/University of Southern California Medical Center between 1980-1985. The rates of occurrence of the eight most common antenatal complications were determined and compared with their incidence in singleton gestations. In addition, complication rates were related to zygosity, levels of antenatal care, and time of antenatal diagnosis. <span class="hlt">Twin</span> gestations had an 83% incidence of antenatal complications, in contrast to a 32% incidence in singleton gestations. The increased complication rate was due to the disproportionate increase in three complications: preterm labor, pregnancy-induced hypertension, and fetal death. Other complications did not occur more frequently in <span class="hlt">twin</span> gestations than in singleton gestations. Monozygotic gestations were more frequently complicated by fetal death, and dizygotic gestations by pregnancy-induced hypertension. PMID:2761906</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015A%26A...581A..34B','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015A%26A...581A..34B"><span id="translatedtitle">The Solar <span class="hlt">Twin</span> Planet Search. II. A Jupiter <span class="hlt">twin</span> around a solar <span class="hlt">twin</span></span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Bedell, M.; Meléndez, J.; Bean, J. L.; Ramírez, I.; Asplund, M.; Alves-Brito, A.; Casagrande, L.; Dreizler, S.; Monroe, T.; Spina, L.; Tucci Maia, M.</p> <p>2015-09-01</p> <p>Context. With high-precision radial velocity surveys reaching a sufficiently long time baseline, the domain of long-period planet detections has recently opened up. The search for Jupiter-like planets is especially important if we wish to investigate the prevalence of solar system analogs, but their detection is complicated by the existence of stellar activity cycles on similar timescales. Radial velocity data with sufficiently long-term instrumental precision and robust methods of diagnosing activity are crucial to the detection of extrasolar Jupiters. Aims: Through our HARPS survey for planets around solar <span class="hlt">twin</span> stars, we have identified a promising Jupiter <span class="hlt">twin</span> candidate around the star HIP11915. We characterize this Keplerian signal and investigate its potential origins in stellar activity. Methods: We carry out a Markov chain Monte Carlo (MCMC) analysis of the radial velocity data. To examine the signal's origin, we employ a variety of statistical tests using activity diagnostics such as the Ca II H and K lines and line asymmetry tracers. Results: Our analysis indicates that HIP11915 hosts a Jupiter-mass planet with a 3800-day orbital period and low eccentricity. Although we cannot definitively rule out an activity cycle interpretation, we find that a planet interpretation is more likely based on a joint analysis of radial velocity and activity index data. Conclusions: The challenges of long-period radial velocity signals addressed in this paper are critical for the ongoing discovery of Jupiter-like exoplanets. If planetary in nature, the signal investigated here represents a very close analog to the solar system in terms of both Sun-like host star and Jupiter-like planet. Table 3 and Fig. 5 are available in electronic form at http://www.aanda.org</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=492911','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=492911"><span id="translatedtitle">Relapsing neurological disorder associated with rubella virus infection in two <span class="hlt">sisters</span>.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Callaghan, N; Feely, M; Walsh, B</p> <p>1977-01-01</p> <p>A disseminated relapsing neurological disorder presented simultaneously in two <span class="hlt">sisters</span>. Encephalitic features were present in one case. The illness was associated with a significant increase in rubella specific IgM in both <span class="hlt">sisters</span>. Despite the absence of a rubella rash, this increase would be compatible with a recent infection by the rubella virus as a basis for the illness, and the persistent elevation, with active antigenic stimulation. It is suggested that both patients might represent the clinical manifestations of perivenous demyelination caused by the rubella virus, which, in view of the relapsing nature of the illness, has progressed to plaque formation. PMID:599358</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4449657','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4449657"><span id="translatedtitle">Screening and Invasive Testing in <span class="hlt">Twins</span></span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Monni, Giovanni; Iuculano, Ambra; Zoppi, Maria Angelica</p> <p>2014-01-01</p> <p>Prenatal screening and testing for trisomy 21 in <span class="hlt">twin</span> pregnancies poses a number of challenges: the exact estimate of the a priori risk of trisomy 21, the choice of prenatal screening test and/or invasive techniques to employ for the diagnosis and the impact of the result on the options of treatment in case of discordant results within a <span class="hlt">twin</span> pair or among multiples. These different aspects are discussed below while recognizing that many issues remain unresolved. PMID:26237482</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/26237482','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/26237482"><span id="translatedtitle">Screening and Invasive Testing in <span class="hlt">Twins</span>.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Monni, Giovanni; Iuculano, Ambra; Zoppi, Maria Angelica</p> <p>2014-01-01</p> <p>Prenatal screening and testing for trisomy 21 in <span class="hlt">twin</span> pregnancies poses a number of challenges: the exact estimate of the a priori risk of trisomy 21, the choice of prenatal screening test and/or invasive techniques to employ for the diagnosis and the impact of the result on the options of treatment in case of discordant results within a <span class="hlt">twin</span> pair or among multiples. These different aspects are discussed below while recognizing that many issues remain unresolved. PMID:26237482</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1049006','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1049006"><span id="translatedtitle">Down's syndrome in <span class="hlt">twins</span> of unlike sex.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Avni, A; Amir, J; Wilunsky, E; Katznelson, M B; Reisner, S H</p> <p>1983-01-01</p> <p>The occurrence of Down's syndrome in both dizygotic <span class="hlt">twins</span> appears to be very rare. A case of <span class="hlt">twins</span> of unlike sex is reported, in which chromosomal analysis showed trisomy 21 in both of them, while the parental karyotypes were normal. This is the third reported case of such a constellation, and the second one in which infant and parental chromosomal analysis was done. Images PMID:6221105</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/1989AmJPh..57..791B','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/1989AmJPh..57..791B"><span id="translatedtitle">The case of the identically accelerated <span class="hlt">twins</span></span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Boughn, S. P.</p> <p>1989-09-01</p> <p>A variation on the ``<span class="hlt">twin</span> paradox'' of special relativity is presented wherein <span class="hlt">twins</span> undergo the same acceleration for the same length of time, yet they age differently. Although this problem is simple to solve, it gets to the heart of the behavior of clocks in special relativity and, hopefully, will help to dispel the notion students develop that the acceleration experienced by a relativistic traveler is directly related to the rate at which that traveler ages.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.depts.ttu.edu/fittech/oldfiles/HealthyRaidersGetMoving.pdf','EPRINT'); return false;" href="http://www.depts.ttu.edu/fittech/oldfiles/HealthyRaidersGetMoving.pdf"><span id="translatedtitle"><span class="hlt">Healthy</span> Raiders Get Moving! Guidelines for <span class="hlt">Healthy</span> Physical Activity</span></a></p> <p><a target="_blank" href="http://www.osti.gov/eprints/">E-print Network</a></p> <p>Rock, Chris</p> <p></p> <p><span class="hlt">Healthy</span> Raiders ­ Get Moving! Guidelines for <span class="hlt">Healthy</span> Physical Activity Texas Tech University faculty, staff, and students should be leaders in <span class="hlt">healthy</span> lifestyles. Eating <span class="hlt">healthy</span> and being physically active and to eat <span class="hlt">healthy</span> while at the workplace or at school. For tips on eating <span class="hlt">healthy</span>, take a look</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://affordability.ku.edu/sites/affordability.ku.edu/files/docs/Lowell%20C.%20Kruse%20Healthy%20Choices,%20Healthy%20Lives%20Scholarship.pdf','EPRINT'); return false;" href="http://affordability.ku.edu/sites/affordability.ku.edu/files/docs/Lowell%20C.%20Kruse%20Healthy%20Choices,%20Healthy%20Lives%20Scholarship.pdf"><span id="translatedtitle">LOWELL C. KRUSE <span class="hlt">HEALTHY</span> CHOICES. <span class="hlt">HEALTHY</span> LIVES. SCHOLARSHIP</span></a></p> <p><a target="_blank" href="http://www.osti.gov/eprints/">E-print Network</a></p> <p></p> <p></p> <p>LOWELL C. KRUSE <span class="hlt">HEALTHY</span> CHOICES. <span class="hlt">HEALTHY</span> LIVES. SCHOLARSHIP Honoring the Legacy of Lowell C. Kruse and Richardson. #12;LOWELL C. KRUSE <span class="hlt">HEALTHY</span> CHOICES. <span class="hlt">HEALTHY</span> LIVES. SCHOLARSHIP Submission Deadline: July 6, 2015 PURPOSE The Lowell C. Kruse <span class="hlt">Healthy</span> Choices. <span class="hlt">Healthy</span> Lives. Scholarship was established in 2009 to provide</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_14");'>14</a></li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li class="active"><span>16</span></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_16 --> <div id="page_17" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li class="active"><span>17</span></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="321"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.nhlbi.nih.gov/files/docs/resources/heart/filipino_pct.pdf','EPRINT'); return false;" href="http://www.nhlbi.nih.gov/files/docs/resources/heart/filipino_pct.pdf"><span id="translatedtitle"><span class="hlt">Healthy</span> Heart, <span class="hlt">Healthy</span> Family Picture Cards for Community Health Workers</span></a></p> <p><a target="_blank" href="http://www.osti.gov/eprints/">E-print Network</a></p> <p>Shen, Jun</p> <p></p> <p><span class="hlt">Healthy</span> Heart, <span class="hlt">Healthy</span> Family Picture Cards for Community Health Workers Puso Mo, Buhay Mo Mga this packet of picture cards. The picture cards can be used with the "<span class="hlt">Healthy</span> Heart, <span class="hlt">Healthy</span> Family" manual to illustrate the topic you are teaching. The "<span class="hlt">Healthy</span> Heart, <span class="hlt">Healthy</span> Family" manual and picture cards are part</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.nidcr.nih.gov/oralhealth/Topics/ToothDecay/Documents/healthybabyFactsheet0103.pdf','NIH-MEDLINEPLUS'); return false;" href="http://www.nidcr.nih.gov/oralhealth/Topics/ToothDecay/Documents/healthybabyFactsheet0103.pdf"><span id="translatedtitle"><span class="hlt">Healthy</span> Mouth for Your Baby</span></a></p> <p><a target="_blank" href="http://medlineplus.gov/">MedlinePLUS</a></p> <p></p> <p></p> <p>... Institute of Dental and Craniofacial Research A <span class="hlt">Healthy</span> Mouth For Your Baby <span class="hlt">Healthy</span> teeth are important—even ... fact sheet can help you keep your baby’s mouth <span class="hlt">healthy</span> and give him a <span class="hlt">healthy</span> start! 1. ...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.cdc.gov/healthywater/swimming/','NIH-MEDLINEPLUS'); return false;" href="http://www.cdc.gov/healthywater/swimming/"><span id="translatedtitle"><span class="hlt">Healthy</span> Swimming/Recreational Water</span></a></p> <p><a target="_blank" href="http://medlineplus.gov/">MedlinePLUS</a></p> <p></p> <p></p> <p>... Facts Index of <span class="hlt">Healthy</span> Water-related Topics <span class="hlt">Healthy</span> Water Sites <span class="hlt">Healthy</span> Water Home Drinking Water <span class="hlt">Healthy</span> Swimming/ ... minimizing the risk of illness and injury. Recreational Water Illness (noun): Illness caused by germs and chemicals ...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://weblaw.haifa.ac.il/he/Events/eveFile/Making%20embryos%20healthy%20or%20making%20healthy%20embryos.pdf','EPRINT'); return false;" href="http://weblaw.haifa.ac.il/he/Events/eveFile/Making%20embryos%20healthy%20or%20making%20healthy%20embryos.pdf"><span id="translatedtitle">'<span class="hlt">Healthy</span>' human embryos and reproduction</span></a></p> <p><a target="_blank" href="http://www.osti.gov/eprints/">E-print Network</a></p> <p>Wintner, Shuly</p> <p></p> <p>'<span class="hlt">Healthy</span>' human embryos and reproduction Making embryos <span class="hlt">healthy</span> or making <span class="hlt">healthy</span> embryos: how much corresponds to the prevailing dis- tinctions drawn in the law and disability scholarship. The `<span class="hlt">Healthy</span>' Embryo</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/23218199','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/23218199"><span id="translatedtitle">The Mid-Atlantic <span class="hlt">Twin</span> Registry, revisited.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Lilley, Emily C H; Silberg, Judy L</p> <p>2013-02-01</p> <p>The Mid-Atlantic <span class="hlt">Twin</span> Registry (MATR) is a population-based registry of more than 56,000 <span class="hlt">twins</span> primarily born or living in Virginia, North Carolina, and South Carolina. The MATR employs several methods of ascertaining <span class="hlt">twins</span>, and devotes considerable resources to tracking and maintaining communication with MATR participants. Researchers may utilize the MATR for administration of research services including study recruitment, collection of DNA, archival data set creation, as well as data collection through mailed, phone, or online surveys. In addition, the MATR houses the MATR Repository, with over 1,200 blood samples available for researchers interested in DNA genotyping. For over 35 years MATR <span class="hlt">twins</span> have participated in research studies with investigators from diverse scientific disciplines and various institutions. These studies, which have resulted in numerous publications, have covered a range of topics, including the human microbiome, developmental psychopathology, depression, anxiety, substance use, epigenetics of aging, children of <span class="hlt">twins</span>, pre-term birth, social attitudes, seizures, eating disorders, as well as sleep homeostasis. Researchers interested in utilizing <span class="hlt">twins</span> are encouraged to contact the MATR to discuss potential research opportunities. PMID:23218199</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4182971','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4182971"><span id="translatedtitle">Imperfect <span class="hlt">twinning</span>: a clinical and ethical dilemma</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Denardin, Daniela; Telles, Jorge Alberto B.; Betat, Rosilene da Silveira; Fell, Paulo Renato K.; da Cunha, André Campos; Targa, Luciano Vieira; Zen, Paulo Ricardo G.; Rosa, Rafael Fabiano M.</p> <p>2013-01-01</p> <p>OBJECTIVE To review the history, epidemiology, etiology, gestational aspects, diagnosis and prognosis of imperfect <span class="hlt">twinning</span>. DATA SOURCES Scientific articles were searched in PubMed, SciELO and Lilacs databases, using the descriptors "conjoined <span class="hlt">twins</span>", "multiple pregnancy", "ultrasound", "magnetic resonance imaging" and "prognosis". The research was not delimited to a specific period of time and was supplemented with bibliographic data from books. DATA SYNTHESIS: The description of conjoined <span class="hlt">twins</span> is legendary. The estimated frequency is 1/45,000-200,000 births. These <span class="hlt">twins</span> are monozygotic, monochorionic and usually monoamniotic. They can be classified by the most prominent fusion site, by the symmetry between the conjoined <span class="hlt">twins</span> or by the sharing structure. The diagnosis can be performed in the prenatal period or after birth by different techniques, such as ultrasound, magnetic resonance imaging and echocardiography. These tests are of paramount importance for understanding the anatomy of both fetuses/children, as well as for prognosis and surgical plan determination. CONCLUSIONS Although imperfect <span class="hlt">twinning</span> is a rare condition, the prenatal diagnosis is very important in order to evaluate the fusion site and its complexity. Hence, the evaluation of these children should be multidisciplinary, involving mainly obstetricians, pediatricians and pediatric surgeons. However, some decisions may constitute real ethical dilemmas, in which different points should be discussed and analyzed with the health team and the family. PMID:24142323</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/FR-2012-11-07/pdf/2012-27237.pdf','FEDREG'); return false;" href="https://www.gpo.gov/fdsys/pkg/FR-2012-11-07/pdf/2012-27237.pdf"><span id="translatedtitle">77 FR 66851 - Submission for OMB Review; Comment Request The <span class="hlt">Sister</span> Study: A Prospective Study of the Genetic...</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collection.action?collectionCode=FR">Federal Register 2010, 2011, 2012, 2013, 2014</a></p> <p></p> <p>2012-11-07</p> <p>... Prospective Study of the Genetic and Environmental Risk Factors for Breast Cancer SUMMARY: Under the... <span class="hlt">Sister</span> Study: A Prospective Study of the Genetic and Environmental Risk Factors for Breast Cancer. Type... for the development of breast cancer in a high-risk cohort of <span class="hlt">sisters</span> of women who have had...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.gpo.gov:80/fdsys/pkg/FR-2012-11-07/pdf/2012-27237.pdf','FEDREG'); return false;" href="http://www.gpo.gov:80/fdsys/pkg/FR-2012-11-07/pdf/2012-27237.pdf"><span id="translatedtitle">77 FR 66851 - Submission for OMB Review; Comment Request The <span class="hlt">Sister</span> Study: A Prospective Study of the Genetic...</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collection.action?collectionCode=FR">Federal Register 2010, 2011, 2012, 2013, 2014</a></p> <p></p> <p>2012-11-07</p> <p>...Phase II follow-up of the <span class="hlt">Sister</span> Study -- a study of genetic and environmental risk...enhancing the ability to detect gene-environment interactions. <span class="hlt">Sisters</span> of women...Response: For the remainder of the study, women will be contacted...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.gpo.gov:80/fdsys/pkg/FR-2012-08-15/pdf/2012-20067.pdf','FEDREG'); return false;" href="http://www.gpo.gov:80/fdsys/pkg/FR-2012-08-15/pdf/2012-20067.pdf"><span id="translatedtitle">77 FR 48993 - Proposed Collection; Comment Request; The <span class="hlt">Sister</span> Study: A Prospective Study of the Genetic and...</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collection.action?collectionCode=FR">Federal Register 2010, 2011, 2012, 2013, 2014</a></p> <p></p> <p>2012-08-15</p> <p>...Phase II follow-up of the <span class="hlt">Sister</span> Study--a study of genetic and environmental risk...enhancing the ability to detect gene- environment interactions. <span class="hlt">Sisters</span> of women...Response: For the remainder of the study, women will be contacted...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://files.eric.ed.gov/fulltext/ED434287.pdf','ERIC'); return false;" href="http://files.eric.ed.gov/fulltext/ED434287.pdf"><span id="translatedtitle">The Effectiveness of Mentoring for Adolescent Mothers and Their Infants: A Comparative Study between <span class="hlt">Sister</span> Friend and Cal Learn.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Tebb, Kathleen P.</p> <p></p> <p>This study evaluated <span class="hlt">Sister</span> Friend, a mentoring program in Yolo County, California, serving low-income adolescent mothers and their infants. The primary objective was to determine if participating in the <span class="hlt">Sister</span> Friend program improved the adolescent mother's parenting class attendance, the home environment, parenting behavior, and child…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://ase.tufts.edu/biology/labs/freudenreich/documents/2011_NewFunctions.pdf','EPRINT'); return false;" href="http://ase.tufts.edu/biology/labs/freudenreich/documents/2011_NewFunctions.pdf"><span id="translatedtitle">New Functions of Ctf18-RFC in Preserving Genome Stability outside Its Role in <span class="hlt">Sister</span> Chromatid Cohesion</span></a></p> <p><a target="_blank" href="http://www.osti.gov/eprints/">E-print Network</a></p> <p>Freudenreich, Catherine</p> <p></p> <p>Cohesion Lionel Gellon1 , David F. Razidlo2 , Olive Gleeson3 , Lauren Verra1 , Danae Schulz1 , Robert S. Surprisingly, chl1, scc1-73, or scc2-4 mutants defective in <span class="hlt">sister</span> chromatid cohesion (SCC) did not increase18-RFC in Preserving Genome Stability outside Its Role in <span class="hlt">Sister</span> Chromatid Cohesion. PLoS Genet 7</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/25985782','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/25985782"><span id="translatedtitle">"If I only touch her cloak": the <span class="hlt">Sisters</span> of Charity of St. Joseph in New Orleans hospital, 1834-1860.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Kong, Hyejung Grace; Kim, Ock-Joo</p> <p>2015-04-01</p> <p>This study is about the <span class="hlt">Sisters</span> of Charity of St. Joseph in New Orleans' Charity Hospital during the years between 1834 and 1860. The <span class="hlt">Sisters</span> of Charity of St. Joseph was founded in 1809 by Saint Elizabeth Ann Bailey Seton (first native-born North American canonized in 1975) in Emmitsburg, Maryland. Seton's <span class="hlt">Sisters</span> of Charity was the first community for religious women to be established in the United States and was later incorporated with the French Daughters of Charity of St. Vincent de Paul in 1850. A call to work in New Orleans' Charity Hospital in the 1830s meant a significant achievement for the <span class="hlt">Sisters</span> of Charity, since it was the second oldest continuously operating public hospitals in the United States until 2005, bearing the same name over the decades. In 1834, <span class="hlt">Sister</span> Regina Smith and other <span class="hlt">sisters</span> were officially called to Charity Hospital, in order to supersede the existing "nurses, attendants, and servants," and take a complete charge of the internal management of Charity Hospital. The existing scholarship on the history of hospitals and Catholic nursing has not integrated the concrete stories of the <span class="hlt">Sisters</span> of Charity into the broader histories of institutionalized medicine, gender, and religion. Along with a variety of primary sources, this study primarily relies on the Charity Hospital History Folder stored at the Daughters of Charity West Center Province Archives. Located in the "Queen city of the South," Charity Hospital was the center of the southern medical profession and the world's fair of people and diseases. Charity Hospital provided the <span class="hlt">sisters</span> with a unique situation that religion and medicine became intertwined. The <span class="hlt">Sisters</span>, as nurses, constructed a new atmosphere of caring for patients and even their families inside and outside the hospital, and built their own separate space within the hospital walls. As hospital managers, the <span class="hlt">Sisters</span> of Charity were put in complete charge of the hospital, which was never seen in other hospitals. By wearing a distinctive religious garment, they eschewed female dependence and sexuality. As medical and religious attendants at the sick wards, the <span class="hlt">sisters</span> played a vital role in preparing the patients for a "good death" as well as spiritual wellness. By waging their own war on the Protestant influences, the <span class="hlt">sisters</span> did their best to build their own sacred place in caring for sick bodies and saving souls. Through the research on the <span class="hlt">Sisters</span> of Charity at Charity Hospital, this study ultimately sheds light on the ways in which a nineteenth-century southern hospital functioned as a unique environment for the recovery of wellness of the body and soul, shaped and envisioned by the Catholic <span class="hlt">sister</span>-nurses' gender and religious identities. PMID:25985782</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2013evga.conf...61H','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2013evga.conf...61H"><span id="translatedtitle">The Onsala <span class="hlt">Twin</span> Telescope Project</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Haas, R.</p> <p>2013-08-01</p> <p>This paper described the Onsala <span class="hlt">Twin</span> Telescope project. The project aims at the construction of two new radio telescopes at the Onsala Space Observatory, following the VLBI2010 concept. The project starts in 2013 and is expected to be finalized within 4 years. Z% O. Rydbeck. Chalmers Tekniska Högskola, Göteborg, ISBN 91-7032-621-5, 407-823, 1991. B. Petrachenko, A. Niell, D. Behrend, B. Corey, J. Böhm, P. Charlot, A. Collioud, J. Gipson, R. Haas, Th. Hobiger, Y. Koyama, D. MacMillan, Z. Malkin, T. Nilsson, A. Pany, G. Tuccari, A. Whitney, and J. Wresnik. Design Aspects of the VLBI2010 System. NASA/TM-2009-214180, 58 pp., 2009. R. Haas, G. Elgered, J. Löfgren, T. Ning, and H.-G. Scherneck. Onsala Space Observatory - IVS Network Station. In K. D. Baver and D. Behrend, editors, International VLBI Service for Geodesy and Astrometry 2011 Annual Report, NASA/TP-2012-217505, 88-91, 2012. H.-G. Scherneck, G. Elgered, J. M. Johansson, and B. O. Rönnäng. Phys. Chem. Earth, Vol. 23, No. 7-8, 811-823, 1998. A. R. Whitney. Ph.D. thesis, Dept. of Electrical engineering, MIT Cambridge, MA., 1974. B. A. Harper, J. D. Kepert, and J. D. Ginger. Guidelines for converting between various wind averaging periods in tropical cyclone conditions. WMO/TD-No. 1555, 64 pp., 2010 (available at \\url{http://www.wmo.int/pages/prog/www/tcp/documents/WMO_TD_1555_en.pdf})</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/20120002933','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/20120002933"><span id="translatedtitle">Aeroacoustic Experiments with <span class="hlt">Twin</span> Jets</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Bozak, Richard F.; Henderson, Brenda S.</p> <p>2012-01-01</p> <p>While the noise produced by a single jet is azimuthally symmetric, multiple jets produce azimuthally varying far-field noise. The ability of one jet to shield another reduces the noise radiated in the plane of the jets, while often increasing the noise radiated out of the plane containing the jets. The present study investigates the shielding potential of <span class="hlt">twin</span> jet configurations over subsonic and over-expanded supersonic jet conditions with simulated forward flight. The experiments were conducted with 2 in. throat diameter nozzles at four jet spacings from 2.6d to 5.5d in center-to-center distance, where d is the nozzle throat diameter. The current study found a maximum of 3 dB reduction in overall sound pressure level relative to two incoherent jets in the peak jet noise direction in the plane containing the jets. However, an increase of 3 dB was found perpendicular to the plane containing the jets. In the sideline direction, shielding is observed for all jet spacings in this study.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://arxiv.org/pdf/0811.3562v2','EPRINT'); return false;" href="http://arxiv.org/pdf/0811.3562v2"><span id="translatedtitle">Langevin's `<span class="hlt">Twin</span> Paradox' paper revisited</span></a></p> <p><a target="_blank" href="http://www.osti.gov/eprints/">E-print Network</a></p> <p>J. H. Field</p> <p>2015-08-04</p> <p>An in-depth and mathematically-detailed analysis of Langevin's popular 1911 article on the special theory of relativity is presented. For the reader's convenience, English translations of large parts of the original French text are given. The self-contradictory nature of many of Langevin's assertions is pointed out. Of special interest is the analysis of the exchange of light signals between the travelling and stay-at-home <span class="hlt">twins</span> in Langevin's thought experiment, in which antinomies are found in the conventional relativistic treatment. Their resolution shows that the physical basis of the differential aging effect in the experiment is not `length contraction', as in the conventional interpretation, but instead the application of the correct relative velocity transformation formula. The spurious nature of the correlated `length contraction' and `relativity of simultaneity' effects of conventional special relativity is also demonstrated. In consequence, an argument given, claiming to demonstrate that an upper limit of $c$ on the speed of any physical signal is required by causality, is invalid. Its conclusion is also in contradiction with astronomical observations and the results of a recent experiment.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/1990PCM....17..320S','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/1990PCM....17..320S"><span id="translatedtitle">Generation of Brazil and Dauphiné <span class="hlt">twins</span> in synthetic amethysts</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Sunagawa, Ichiro; Taijing, Lu; Balitsky, V. S.</p> <p>1990-09-01</p> <p>The generation of both Brazil and Dauphiné <span class="hlt">twins</span> is triggered by strain fields associated with the fluctuation of growth parameters when solid inclusions of goethite (?) are precipitated on to a growth surface. Brazil <span class="hlt">twins</span> are generated either directly from solid inclusions of smaller size or dislocations originating therefrom, whereas Dauphiné <span class="hlt">twins</span> are generated only directly from solid inclusions of larger size. Precipitation of polymerized embryonic particles of SiO2 on the surface of solid inclusions is considered to be responsible for the generation of Brazil <span class="hlt">twins</span>, whereas for Dauphiné <span class="hlt">twins</span> it is necessary that embryonic particles precipitated in <span class="hlt">twin</span> orientation on the surface of solid inclusions grow beyond a critical size.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/servlets/purl/1050020','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/servlets/purl/1050020"><span id="translatedtitle">Deformation <span class="hlt">twinning</span> mechanisms in FCC and HCP metals</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Wang, Jian; Tome, Carlos N; Beyerlein, Irene J; Misra, Amit; Mara, N</p> <p>2011-01-31</p> <p>We report the recent work on <span class="hlt">twinning</span> and detwinning in fcc and hcp metals based on the in situ and ex situ TEM observations and molecular dynamics simulations. Three aspects are discussed in this paper. (1) Detwinning in single-phase Cu with respect to growth <span class="hlt">twins</span>, (2) deformation <span class="hlt">twinning</span> in Ag-Cu composites, and (3) deformation <span class="hlt">twinning</span> mechanisms in hcp metals. The main conclusion is that atomic structures of interfaces (<span class="hlt">twin</span> boundaries, two-phases interface, and grain boundaries) play a crucial role in nucleating and propagating of deformation <span class="hlt">twins</span>.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://files.eric.ed.gov/fulltext/ED514909.pdf','ERIC'); return false;" href="http://files.eric.ed.gov/fulltext/ED514909.pdf"><span id="translatedtitle">Serving, Learning and Mentoring through the Big Brothers Big <span class="hlt">Sisters</span> Program</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Sivukamaran, Thillainatarajan; Holland, Glenda; Clark, Leonard J.</p> <p>2010-01-01</p> <p>This study describes the collaborative partnership between a Big Brothers Big <span class="hlt">Sisters</span> organization, an elementary school and the College of Education at a public university. The partnership utilized a mentoring system consisting of elementary students, college students, elementary teachers and university faculty. Benefits of the various…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=incest&id=EJ1011495','ERIC'); return false;" href="http://eric.ed.gov/?q=incest&id=EJ1011495"><span id="translatedtitle">Brother-<span class="hlt">Sister</span> Incest: Data from Anonymous Computer-Assisted Self Interviews</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Stroebel, Sandra S.; O'Keefe, Stephen L.; Beard, Keith W.; Kuo, Shih-Ya; Swindell, Samuel; Stroupe, Walter</p> <p>2013-01-01</p> <p>Retrospective data were entered anonymously by 1,521 adult women using computer-assisted self interview. Forty were classified as victims of brother-<span class="hlt">sister</span> incest, 19 were classified as victims of father-daughter incest, and 232 were classified as victims of sexual abuse by an adult other than their father before reaching 18 years of age. The…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1050774','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1050774"><span id="translatedtitle">Two <span class="hlt">sisters</span> with a syndrome of ocular, skeletal, and abdominal abnormalities (OSA syndrome).</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Mingarelli, R; Castriota Scanderbeg, A; Dallapiccola, B</p> <p>1996-01-01</p> <p>Two adult <span class="hlt">sisters</span> are described who had a unique association of facial, ocular, and skeletal defects, and abdominal muscle hypoplasia, indicating autosomal recessive inheritance. Many of these features overlap those previously found in other malformation syndromes. However, the constellation of defects observed in these patients appears to represent a previously unreported syndrome and autosomal recessive inheritance is likely. Images PMID:8933348</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li class="active"><span>17</span></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_17 --> <div id="page_18" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li class="active"><span>18</span></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="341"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=turner%27s+AND+syndrome&pg=2&id=EJ579567','ERIC'); return false;" href="http://eric.ed.gov/?q=turner%27s+AND+syndrome&pg=2&id=EJ579567"><span id="translatedtitle">Social Functioning among Girls with Fragile X or Turner Syndrome and Their <span class="hlt">Sisters</span>.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Mazzocco, Michele M. M.; Baumgardner, Thomas; Freund, Lisa S.; Reiss, Allan L.</p> <p>1998-01-01</p> <p>Social behaviors among girls (ages 6-16) with fragile X (n=8) or Turner syndrome (n=9) were examined to address the role of family environment versus biological determinants of social dysfunction. Compared to their <span class="hlt">sisters</span>, subjects had lower IQS and higher rating of social and attention problems. (Author/CR)</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=Weed&pg=3&id=EJ797780','ERIC'); return false;" href="http://eric.ed.gov/?q=Weed&pg=3&id=EJ797780"><span id="translatedtitle">Three <span class="hlt">Sisters</span>: Lessons of Traditional Story Honored in Assessment and Accreditation</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Chenault, Venida S.</p> <p>2008-01-01</p> <p>The three <span class="hlt">sisters</span> story is shared across many tribes. It explains the practice of planting corn, beans, and squash together. The corn stalks provide support for the bean vines; the beans provide nitrogen for the corn; and the squash prevents weed growth between the mounds. Such stories explain not only the science of agricultural methods in tribal…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/servlets/purl/827476','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/servlets/purl/827476"><span id="translatedtitle">Los Alamos National Laboratory's <span class="hlt">Sister</span> Laboratory Collaborations on Low and Intermediate Level Radioactive Waste Management</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Newell, D. L.; Sinkule, B. J.; Apt, K. E.</p> <p>2003-02-25</p> <p>The DOE/National Nuclear Security Administration's (NNSA) ''<span class="hlt">Sister</span> Laboratory'' program allows for bilateral technical cooperation in peaceful uses of nuclear energy for developing nations. The program establishes a direct line of communication between U.S. scientists and the nuclear research and scientific communities in participating countries.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.aip.de/groups/sternphysik/stp/PDFFILES/2000/gaia_paper.pdf','EPRINT'); return false;" href="http://www.aip.de/groups/sternphysik/stp/PDFFILES/2000/gaia_paper.pdf"><span id="translatedtitle">Determination of Habitable Zones in Extrasolar Planetary Systems: Where are Gaia's <span class="hlt">Sisters</span>?</span></a></p> <p><a target="_blank" href="http://www.osti.gov/eprints/">E-print Network</a></p> <p></p> <p></p> <p>1 Determination of Habitable Zones in Extrasolar Planetary Systems: Where are Gaia's <span class="hlt">Sisters</span> scheme for assessing the suitability for life of extrasolar planets is pre- sented. The scheme focuses on the identification of the "habitable zone" in main-sequence star planetary systems accommodating Earth</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=bullying+AND+children+AND+difficulties&pg=3&id=EJ830840','ERIC'); return false;" href="http://eric.ed.gov/?q=bullying+AND+children+AND+difficulties&pg=3&id=EJ830840"><span id="translatedtitle">Brothers and <span class="hlt">Sisters</span>: A Source of Support for Children in School?</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Hadfield, Lucy; Edwards, Rosalind; Mauthner, Melanie</p> <p>2006-01-01</p> <p>Whilst UK schools move towards U.S "big brother" style mentoring systems for children, are actual brothers and <span class="hlt">sisters</span> becoming an invisible source of support to deal with bullying in everyday life? This paper reports on research with children aged 7-13 about their experiences and understandings of their relationships with their brothers and…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2011-title20-vol2/pdf/CFR-2011-title20-vol2-sec410-215.pdf','CFR2011'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2011-title20-vol2/pdf/CFR-2011-title20-vol2-sec410-215.pdf"><span id="translatedtitle">20 CFR 410.215 - Duration of entitlement; parent, brother, or <span class="hlt">sister</span>.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2011&page.go=Go">Code of Federal Regulations, 2011 CFR</a></p> <p></p> <p>2011-04-01</p> <p>... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false Duration of entitlement; parent, brother, or <span class="hlt">sister</span>. 410.215 Section 410.215 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL COAL MINE HEALTH AND SAFETY ACT OF 1969, TITLE IV-BLACK LUNG BENEFITS (1969- ) Requirements for...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=chess&pg=3&id=EJ939604','ERIC'); return false;" href="http://eric.ed.gov/?q=chess&pg=3&id=EJ939604"><span id="translatedtitle">Does High-Level Intellectual Performance Depend on Practice Alone? Debunking the Polgar <span class="hlt">Sisters</span> Case</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Howard, Robert W.</p> <p>2011-01-01</p> <p>The famous Polgar <span class="hlt">sisters</span> started chess very young, undertook extensive study, and two became grandmasters. This case often is cited as decisive evidence that practice alone is key in development of expertise, that innate talent is unimportant or non-existent, and that almost anyone can become a grandmaster. But on close examination these claims…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=single-sex+AND+education+AND+benefits+AND+girls&pg=4&id=EJ587581','ERIC'); return false;" href="http://eric.ed.gov/?q=single-sex+AND+education+AND+benefits+AND+girls&pg=4&id=EJ587581"><span id="translatedtitle"><span class="hlt">Sisters</span> in Science: An Intergenerational Science Program for Elementary School Girls.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Hammrich, Penny L.</p> <p>1998-01-01</p> <p>Once a week, several classrooms of Philadelphia 4th-grade girls participate in <span class="hlt">Sisters</span> in Science, an afterschool, intergenerational program sponsored by Temple University that provides hand-on activities exploring urban environmental issues. A two-week summer camp program helps these students explore the rivers of Philadelphia. Participants…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://cfpub.epa.gov/si/si_public_record_report.cfm?dirEntryId=43487&keyword=sce&actType=&TIMSType=+&TIMSSubTypeID=&DEID=&epaNumber=&ntisID=&archiveStatus=Both&ombCat=Any&dateBeginCreated=&dateEndCreated=&dateBeginPublishedPresented=&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&dateBeginCompleted=&dateEndCompleted=&personID=&role=Any&journalID=&publisherID=&sortBy=revisionDate&count=50&CFID=55247118&CFTOKEN=47609708','EPA-EIMS'); return false;" href="http://cfpub.epa.gov/si/si_public_record_report.cfm?dirEntryId=43487&keyword=sce&actType=&TIMSType=+&TIMSSubTypeID=&DEID=&epaNumber=&ntisID=&archiveStatus=Both&ombCat=Any&dateBeginCreated=&dateEndCreated=&dateBeginPublishedPresented=&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&dateBeginCompleted=&dateEndCompleted=&personID=&role=Any&journalID=&publisherID=&sortBy=revisionDate&count=50&CFID=55247118&CFTOKEN=47609708"><span id="translatedtitle">EVIDENCE FOR THE CHROMOSOMAL REPLICONS AS UNITS OF <span class="hlt">SISTER</span> CHROMATID EXCHANGES</span></a></p> <p><a target="_blank" href="http://oaspub.epa.gov/eims/query.page">EPA Science Inventory</a></p> <p></p> <p></p> <p>Current hypotheses of <span class="hlt">sister</span> chromatid exchange (SCE) formation postulate that sites of SCE induction are associated with active replicons or replicon clusters. We have applied the FCC-SCD technique to in vivo studies of mouse bone marrow cells that have been treated with cycloph...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=moral+AND+enhancement&id=EJ755531','ERIC'); return false;" href="http://eric.ed.gov/?q=moral+AND+enhancement&id=EJ755531"><span id="translatedtitle">Meanings of Sisterhood and Developmental Disability: Narratives from White Nondisabled <span class="hlt">Sisters</span></span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>McGraw, Lori A.; Walker, Alexis J.</p> <p>2007-01-01</p> <p>Integrating thought from critical feminist and disability theorists via a strategic social constructionist perspective, the authors analyzed 10 in-depth qualitative interviews to begin to understand the dialogue between (a) how nondisabled <span class="hlt">sisters</span> understand themselves and their siblings with developmental disabilities and (b) wider systems of…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.hedgeslab.org/pubs/28.pdf','EPRINT'); return false;" href="http://www.hedgeslab.org/pubs/28.pdf"><span id="translatedtitle">Letter to the Editor Pancreatic Polypeptide and the <span class="hlt">Sister</span> Group of Birds 1</span></a></p> <p><a target="_blank" href="http://www.osti.gov/eprints/">E-print Network</a></p> <p>Hedges, Blair</p> <p></p> <p>Letter to the Editor Pancreatic Polypeptide and the <span class="hlt">Sister</span> Group of Birds 1 S. Blair Hedges on the type of analysis. An additional gene, pancreatic poly- peptide (also referred to as pancreatic hormone-rate model, amniote relationships. All 14 available sequences of pancreatic polypeptide were obtained from</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=Psychology+AND+creative+AND+process&pg=4&id=EJ1003992','ERIC'); return false;" href="http://eric.ed.gov/?q=Psychology+AND+creative+AND+process&pg=4&id=EJ1003992"><span id="translatedtitle">Empirical Psycho-Aesthetics and Her <span class="hlt">Sisters</span>: Substantive and Methodological Issues--Part II</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Konecni, Vladimir J.</p> <p>2013-01-01</p> <p>Empirical psycho-aesthetics is approached in this two-part article from two directions. Part I, which appeared in the Winter 2012 issue of "JAE," addressed definitional and organizational issues, including the field's origins, its relation to "<span class="hlt">sister</span>" disciplines (experimental philosophy, cognitive neuroscience of art, and neuroaesthetics), and…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://files.eric.ed.gov/fulltext/ED404313.pdf','ERIC'); return false;" href="http://files.eric.ed.gov/fulltext/ED404313.pdf"><span id="translatedtitle"><span class="hlt">Sister</span> Schools: An Experience in Culture Vision for Preservice Teachers and Elementary Children.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Black, Sharon J.; Cutler, Beverly R.</p> <p></p> <p>The School of Education at Brigham Young University (BYU) in Utah developed a <span class="hlt">sister</span> school program with teachers and children in Cuauhtemoc and Dublan (Mexico) to increase the culture vision of preservice teachers while simultaneously allowing elementary school children to develop culture awareness by participating in a cross-cultural learning…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=emotion+AND+Regulation+AND+Children&pg=6&id=EJ818749','ERIC'); return false;" href="http://eric.ed.gov/?q=emotion+AND+Regulation+AND+Children&pg=6&id=EJ818749"><span id="translatedtitle">Improving Emotion Regulation and Sibling Relationship Quality: The More Fun with <span class="hlt">Sisters</span> and Brothers Program</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Kennedy, Denise E.; Kramer, Laurie</p> <p>2008-01-01</p> <p>We examined the role of emotion regulation (ER) in improving sibling relationship quality (SRQ) by evaluating the More Fun With <span class="hlt">Sisters</span> and Brothers Program where 4- to 8-year-old siblings from 95 families were taught emotional and social competencies. Parents reported on SRQ and ER, and sibling interactions were observed in homes. SRQ and ER…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=new&pg=4&id=EJ1048143','ERIC'); return false;" href="http://eric.ed.gov/?q=new&pg=4&id=EJ1048143"><span id="translatedtitle">They Came with a Purpose: Educational Journeys of Nineteenth-Century Irish Dominican <span class="hlt">Sister</span> Teachers</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Collins, Jenny</p> <p>2015-01-01</p> <p>Irish Catholic teaching <span class="hlt">sisters</span> were major actors in the development of education systems in New World countries such as the United States, Canada, South Africa, Australia and New Zealand. Immigrants themselves, they faced a number of key challenges as they sought to adapt Old World cultural and educational ideas to the education of the immigrant…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=Ideology&pg=4&id=EJ997719','ERIC'); return false;" href="http://eric.ed.gov/?q=Ideology&pg=4&id=EJ997719"><span id="translatedtitle">A Tale of Three <span class="hlt">Sisters</span>: Language Ideologies, Identities, and Negotiations in a Bilingual, Transnational Family</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>King, Kendall A.</p> <p>2013-01-01</p> <p>This longitudinal case study investigated how linguistic identity was constructed, constrained, and performed by three <span class="hlt">sisters</span>, aged 1, 12, and 17, within one bilingual, transnational Ecuadorian-U.S. family. Data were collected over 14 months through weekly home visits that included participant observation, informal interviews, and…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=music+AND+introduce+AND+other+AND+cultures&pg=2&id=ED266892','ERIC'); return false;" href="http://eric.ed.gov/?q=music+AND+introduce+AND+other+AND+cultures&pg=2&id=ED266892"><span id="translatedtitle">Walking with Grandfather and Great Wolf and Little Mouse <span class="hlt">Sister</span>. Teacher's Guide.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Lethbridge Univ. (Alberta).</p> <p></p> <p>Written for use with videotaped versions of the stories "Walking with Grandfather" and "Great Wolf and Little Mouse <span class="hlt">Sister</span>," this guide presents 20 lessons that teachers can adapt for students of various ages and use in integrated units or other curriculum approaches. The introductory material describes the use and philosophy of the video stories,…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=teenage+AND+development&pg=3&id=EJ965819','ERIC'); return false;" href="http://eric.ed.gov/?q=teenage+AND+development&pg=3&id=EJ965819"><span id="translatedtitle">Youths' Caretaking of Their Adolescent <span class="hlt">Sisters</span>' Children: Its Costs and Benefits for Youths' Development</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>East, Patricia L.; Weisner, Thomas S.; Reyes, Barbara T.</p> <p>2006-01-01</p> <p>This study examined how time spent caring for a teenage <span class="hlt">sister</span>'s child and experiences in providing care related to youths' young adult outcomes. Latino and African American youths (N = 108) were studied during middle and late adolescence. Results indicated that youths who provided many hours of child care were more stressed and had lower school…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4125069','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4125069"><span id="translatedtitle">Tethering <span class="hlt">Sister</span> Centromeres to Each Other Suggests the Spindle Checkpoint Detects Stretch within the Kinetochore</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Nannas, Natalie J.; Murray, Andrew W.</p> <p>2014-01-01</p> <p>The spindle checkpoint ensures that newly born cells receive one copy of each chromosome by preventing chromosomes from segregating until they are all correctly attached to the spindle. The checkpoint monitors tension to distinguish between correctly aligned chromosomes and those with both <span class="hlt">sisters</span> attached to the same spindle pole. Tension arises when <span class="hlt">sister</span> kinetochores attach to and are pulled toward opposite poles, stretching the chromatin around centromeres and elongating kinetochores. We distinguished between two hypotheses for where the checkpoint monitors tension: between the kinetochores, by detecting alterations in the distance between them, or by responding to changes in the structure of the kinetochore itself. To distinguish these models, we inhibited chromatin stretch by tethering <span class="hlt">sister</span> chromatids together by binding a tetrameric form of the Lac repressor to arrays of the Lac operator located on either side of a centromere. Inhibiting chromatin stretch did not activate the spindle checkpoint; these cells entered anaphase at the same time as control cells that express a dimeric version of the Lac repressor, which cannot cross link chromatids, and cells whose checkpoint has been inactivated. There is no dominant checkpoint inhibition when <span class="hlt">sister</span> kinetochores are held together: cells expressing the tetrameric Lac repressor still arrest in response to microtubule-depolymerizing drugs. Tethering chromatids together does not disrupt kinetochore function; chromosomes are successfully segregated to opposite poles of the spindle. Our results indicate that the spindle checkpoint does not monitor inter-kinetochore separation, thus supporting the hypothesis that tension is measured within the kinetochore. PMID:25101645</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/25902535','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/25902535"><span id="translatedtitle">Error, signal, and the placement of Ctenophora <span class="hlt">sister</span> to all other animals.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Whelan, Nathan V; Kocot, Kevin M; Moroz, Leonid L; Halanych, Kenneth M</p> <p>2015-05-01</p> <p>Elucidating relationships among early animal lineages has been difficult, and recent phylogenomic analyses place Ctenophora <span class="hlt">sister</span> to all other extant animals, contrary to the traditional view of Porifera as the earliest-branching animal lineage. To date, phylogenetic support for either ctenophores or sponges as <span class="hlt">sister</span> to other animals has been limited and inconsistent among studies. Lack of agreement among phylogenomic analyses using different data and methods obscures how complex traits, such as epithelia, neurons, and muscles evolved. A consensus view of animal evolution will not be accepted until datasets and methods converge on a single hypothesis of early metazoan relationships and putative sources of systematic error (e.g., long-branch attraction, compositional bias, poor model choice) are assessed. Here, we investigate possible causes of systematic error by expanding taxon sampling with eight novel transcriptomes, strictly enforcing orthology inference criteria, and progressively examining potential causes of systematic error while using both maximum-likelihood with robust data partitioning and Bayesian inference with a site-heterogeneous model. We identified ribosomal protein genes as possessing a conflicting signal compared with other genes, which caused some past studies to infer ctenophores and cnidarians as <span class="hlt">sister</span>. Importantly, biases resulting from elevated compositional heterogeneity or elevated substitution rates are ruled out. Placement of ctenophores as <span class="hlt">sister</span> to all other animals, and sponge monophyly, are strongly supported under multiple analyses, herein. PMID:25902535</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li class="active"><span>18</span></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_18 --> <div id="page_19" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li class="active"><span>19</span></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="361"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4426464','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4426464"><span id="translatedtitle">Error, signal, and the placement of Ctenophora <span class="hlt">sister</span> to all other animals</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Whelan, Nathan V.; Kocot, Kevin M.; Moroz, Leonid L.</p> <p>2015-01-01</p> <p>Elucidating relationships among early animal lineages has been difficult, and recent phylogenomic analyses place Ctenophora <span class="hlt">sister</span> to all other extant animals, contrary to the traditional view of Porifera as the earliest-branching animal lineage. To date, phylogenetic support for either ctenophores or sponges as <span class="hlt">sister</span> to other animals has been limited and inconsistent among studies. Lack of agreement among phylogenomic analyses using different data and methods obscures how complex traits, such as epithelia, neurons, and muscles evolved. A consensus view of animal evolution will not be accepted until datasets and methods converge on a single hypothesis of early metazoan relationships and putative sources of systematic error (e.g., long-branch attraction, compositional bias, poor model choice) are assessed. Here, we investigate possible causes of systematic error by expanding taxon sampling with eight novel transcriptomes, strictly enforcing orthology inference criteria, and progressively examining potential causes of systematic error while using both maximum-likelihood with robust data partitioning and Bayesian inference with a site-heterogeneous model. We identified ribosomal protein genes as possessing a conflicting signal compared with other genes, which caused some past studies to infer ctenophores and cnidarians as <span class="hlt">sister</span>. Importantly, biases resulting from elevated compositional heterogeneity or elevated substitution rates are ruled out. Placement of ctenophores as <span class="hlt">sister</span> to all other animals, and sponge monophyly, are strongly supported under multiple analyses, herein. PMID:25902535</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/26728792','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/26728792"><span id="translatedtitle">Overlap microtubules link <span class="hlt">sister</span> k-fibres and balance the forces on bi-oriented kinetochores.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Kajtez, Janko; Solomatina, Anastasia; Novak, Maja; Polak, Bruno; Vukuši?, Kruno; Rüdiger, Jonas; Cojoc, Gheorghe; Milas, Ana; Šumanovac Šestak, Ivana; Risteski, Patrik; Tavano, Federica; Klemm, Anna H; Roscioli, Emanuele; Welburn, Julie; Cimini, Daniela; Glun?i?, Matko; Pavin, Nenad; Toli?, Iva M</p> <p>2016-01-01</p> <p>During metaphase, forces on kinetochores are exerted by k-fibres, bundles of microtubules that end at the kinetochore. Interestingly, non-kinetochore microtubules have been observed between <span class="hlt">sister</span> kinetochores, but their function is unknown. Here we show by laser-cutting of a k-fibre in HeLa and PtK1 cells that a bundle of non-kinetochore microtubules, which we term 'bridging fibre', bridges <span class="hlt">sister</span> k-fibres and balances the interkinetochore tension. We found PRC1 and EB3 in the bridging fibre, suggesting that it consists of antiparallel dynamic microtubules. By using a theoretical model that includes a bridging fibre, we show that the forces at the pole and at the kinetochore depend on the bridging fibre thickness. Moreover, our theory and experiments show larger relaxation of the interkinetochore distance for cuts closer to kinetochores. We conclude that the bridging fibre, by linking <span class="hlt">sister</span> k-fibres, withstands the tension between <span class="hlt">sister</span> kinetochores and enables the spindle to obtain a curved shape. PMID:26728792</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=Networking&pg=2&id=EJ1078896','ERIC'); return false;" href="http://eric.ed.gov/?q=Networking&pg=2&id=EJ1078896"><span id="translatedtitle">Teaching <span class="hlt">Sisters</span> and Transnational Networks: Recruitment and Education Expansion in the Long Nineteenth Century</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Raftery, Deirdre</p> <p>2015-01-01</p> <p>This article examines the management of the education enterprise of teaching <span class="hlt">Sisters</span>, with reference to their transnational networking. The article suggests that orders of women religious were the first all-female transnational networks, engaged constantly in work that was characterised by "movement, ebb and circulation". The mobility of…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.gpo.gov:80/fdsys/pkg/FR-2010-12-17/pdf/2010-31745.pdf','FEDREG'); return false;" href="http://www.gpo.gov:80/fdsys/pkg/FR-2010-12-17/pdf/2010-31745.pdf"><span id="translatedtitle">75 FR 78979 - Application to Export Electric Energy; <span class="hlt">Twin</span> Rivers Paper Company Inc.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collection.action?collectionCode=FR">Federal Register 2010, 2011, 2012, 2013, 2014</a></p> <p></p> <p>2010-12-17</p> <p>...to Export Electric Energy; <span class="hlt">Twin</span> Rivers Paper Company Inc. AGENCY: Office of Electricity...SUMMARY: <span class="hlt">Twin</span> Rivers Paper Company Inc. (<span class="hlt">Twin</span> Rivers) has applied...69-kV, connect the integrated pulp and paper operations owned by <span class="hlt">Twin</span> Rivers and...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/23101474','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/23101474"><span id="translatedtitle">The Project TALENT <span class="hlt">Twin</span> and Sibling Study.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Prescott, Carol A; Achorn, Deanna Lyter; Kaiser, Ashley; Mitchell, Lindsey; McArdle, John J; Lapham, Susan J</p> <p>2013-02-01</p> <p>Project TALENT is a US national longitudinal study of about 377,000 individuals born in 1942-1946, first assessed in 1960. Students in about 1,200 schools participated in a 2-day battery covering aptitudes, abilities, interests, and individual and family characteristics (Flanagan, 1962; www.projectTALENT.org). Follow-up assessments 1, 5, and 11 years later assessed educational and occupational outcomes. The sample includes approximately 92,000 siblings from 40,000 families, including 2,500 <span class="hlt">twin</span> pairs and 1,200 other siblings of <span class="hlt">twins</span>. Until recently, almost no behavior genetic research has been conducted with the sample. In the original data collection information was not collected with the intent to link family members. Recently, we developed algorithms using names, addresses, birthdates, and information about family structure to link siblings and identify <span class="hlt">twins</span>. We are testing several methods to determine zygosity, including use of yearbook photographs. In this paper, we summarize the design and measures in Project TALENT, describe the <span class="hlt">Twin</span> and Sibling sample, and present our <span class="hlt">twin</span>-sib-classmate model. In most <span class="hlt">twin</span> and family designs, the 'shared environment' includes factors specific to the family combined with between-family differences associated with macro-level variables such as socioeconomic status. The school-based sampling design used in Project TALENT provides a unique opportunity to partition the shared environment into variation shared by siblings, specific to <span class="hlt">twins</span>, and associated with school- and community-level factors. The availability of many measured characteristics on the family, schools, and neighborhoods enhances the ability to study the impact of specific factors on behavioral variation. PMID:23101474</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2039867','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2039867"><span id="translatedtitle">Anthropometry, carbohydrate and lipid metabolism in the East Flanders Prospective <span class="hlt">Twin</span> Survey: heritabilities</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Souren, N. Y.; Loos, R. J. F.; Gielen, M.; Beunen, G.; Fagard, R.; Derom, C.; Vlietinck, R.; Zeegers, M. P.</p> <p>2007-01-01</p> <p>Aims/hypothesis We determined the genetic contribution of 18 anthropometric and metabolic risk factors of type 2 diabetes using a young <span class="hlt">healthy</span> <span class="hlt">twin</span> population. Methods Traits were measured in 240 monozygotic (MZ) and 138 dizygotic (DZ) <span class="hlt">twin</span> pairs aged 18 to 34 years. <span class="hlt">Twins</span> were recruited from the Belgian population-based East Flanders Prospective <span class="hlt">Twin</span> Survey, which is characterised by its accurate zygosity determination and extensive collection of perinatal and placental data, including information on chorionicity. Heritability was estimated using structural equation modelling implemented in the Mx software package. Results Intra-pair correlations of the anthropometric and metabolic characteristics did not differ between MZ monochorionic and MZ dichorionic pairs; consequently heritabilities were estimated using the classical <span class="hlt">twin</span> approach. For body mass, BMI and fat mass, quantitative sex differences were observed; genetic variance explained 84, 85 and 81% of the total variation in men and 74, 75 and 70% in women, respectively. Heritability estimates of the waist-to-hip ratio, sum of four skinfold thicknesses and lean body mass were 70, 74 and 81%, respectively. The heritability estimates of fasting glucose, fasting insulin, homeostasis model assessment of insulin resistance and beta cell function, as well as insulin-like growth factor binding protein-1 levels were 67, 49, 48, 62 and 47%, in that order. Finally, for total cholesterol, LDL-cholesterol, HDL-cholesterol, total cholesterol:HDL-cholesterol ratio, triacylglycerol, NEFA and leptin levels, genetic factors explained 75, 78, 76, 79, 58, 37 and 53% of the total variation, respectively. Conclusions/interpretation Genetic factors explain the greater part of the variation in traits related to obesity, glucose intolerance/insulin resistance and dyslipidaemia. Electronic supplementary material The online version of this article (doi:10.1007/s00125-007-0784-z) contains supplementary material, which is available to authorised users. PMID:17694296</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/10779336','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/10779336"><span id="translatedtitle">Fission yeast Eso1p is required for establishing <span class="hlt">sister</span> chromatid cohesion during S phase.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Tanaka, K; Yonekawa, T; Kawasaki, Y; Kai, M; Furuya, K; Iwasaki, M; Murakami, H; Yanagida, M; Okayama, H</p> <p>2000-05-01</p> <p><span class="hlt">Sister</span> chromatid cohesion is essential for cell viability. We have isolated a novel temperature-sensitive lethal mutant named eso1-H17 that displays spindle assembly checkpoint-dependent mitotic delay and abnormal chromosome segregation. At the permissive temperature, the eso1-H17 mutant shows mild sensitivity to UV irradiation and DNA-damaging chemicals. At the nonpermissive temperature, the mutant is arrested in M phase with a viability loss due to a failure to establish <span class="hlt">sister</span> chromatid cohesion during S phase. The lethal M-phase arrest phenotype, however, is suppressed by inactivation of a spindle checkpoint. The eso1(+) gene is not essential for the onset and progression of DNA replication but has remarkable genetic interactions with those genes regulating the G(1)-S transition and DNA replication. The N-terminal two-thirds of Eso1p is highly homologous to DNA polymerase eta of budding yeast and humans, and the C-terminal one-third is homologous to budding yeast Eco1p (also called Ctf7p), which is required for the establishment of <span class="hlt">sister</span> chromatid cohesion. Deletion analysis and determination of the mutation site reveal that the function of the Eco1p/Ctf7p-homologous domain is necessary and sufficient for <span class="hlt">sister</span> chromatid cohesion. On the other hand, deletion of the DNA polymerase eta domain in Eso1p increases sensitivity to UV irradiation. These results indicate that Eso1p plays a dual role during DNA replication. The C-terminal region acts to establish <span class="hlt">sister</span> chromatid cohesion, and the N-terminal region presumably catalyzes translesion DNA synthesis when template DNA contains lesions that block regular DNA replication. PMID:10779336</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/19910019855','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/19910019855"><span id="translatedtitle">NAE <span class="hlt">Twin</span> Otter operations in FIFE 1989</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Macpherson, J. I.</p> <p>1990-01-01</p> <p>During the summer of 1989, the National Aeronautical Establishment (Canada) <span class="hlt">Twin</span> Otter Atmospheric Research Aircraft was flow in support of the NASA sponsored First ISLSCP (International Satellite Land Surface Climatology Project) Field Experiment called FIFE-89. Airborne measurements of the fluxes of heat, momentum, water vapor and carbon dioxide were made during 16 flow-altitude flights over the FIFE project area in central Kansas. The <span class="hlt">Twin</span> Otter operations in FIFE are documented and details are included on the instrumentation, software, flight procedures, atmospheric conditions and analysis methods. Comparisons of <span class="hlt">Twin</span> Otter measured fluxes are made with those determined at several surface sites and with those made by other instrumented aircraft in the FIFE-87 measurements. Airborne flux measurements are related to run length, altitude, and environmental parameters such as vegetation type, temperature, and wind speed. One night flight was run in an attempt to measure the respiration component of the CO2 flux. The use of aircraft was studied for regional observations of fluxes and to relate these to satellite radiance measurements. Run average data are presented for all 285 flux runs flown by the <span class="hlt">Twin</span> Otter in FIFE-89. This should serve as as a working reference for scientists utilizing <span class="hlt">Twin</span> Otter data either directly of through the FIFE data archive.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=home&id=EJ1042704','ERIC'); return false;" href="http://eric.ed.gov/?q=home&id=EJ1042704"><span id="translatedtitle"><span class="hlt">Healthy</span> Homes Tools</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Peek, Gina; Lyon, Melinda; Russ, Randall</p> <p>2012-01-01</p> <p>Extension is focusing on <span class="hlt">healthy</span> homes programming. Extension educators are not qualified to diagnose consumers' medical problems as they relate to housing. We cannot give medical advice. Instead, we can help educate consumers about home conditions that may affect their well-being. Extension educators need appropriate <span class="hlt">healthy</span> homes tools to…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=healthy&pg=6&id=EJ1059804','ERIC'); return false;" href="http://eric.ed.gov/?q=healthy&pg=6&id=EJ1059804"><span id="translatedtitle">Active and <span class="hlt">Healthy</span> Schools</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Ball, Stephen; Kovarik, Jessica; Leidy, Heather</p> <p>2015-01-01</p> <p>The Active and <span class="hlt">Healthy</span> School Program (AHS) can be used to alter the culture and environment of a school to help children make healthier choices. The purpose of this study was to determine the effectiveness of AHS to increase physical activity while decreasing total screen time, increase <span class="hlt">healthy</span> food choices, and improve knowledge about physical…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://nature.berkeley.edu/battles/personnel/wenk/Rebecca%20Memorial.pdf','EPRINT'); return false;" href="http://nature.berkeley.edu/battles/personnel/wenk/Rebecca%20Memorial.pdf"><span id="translatedtitle">Rebecca Ciresa Wenk 11.27.1979 7.14.2011 Rebecca grew up and attended school in Berkeley. She was the middle child of three <span class="hlt">sisters</span>.</span></a></p> <p><a target="_blank" href="http://www.osti.gov/eprints/">E-print Network</a></p> <p>Battles, John</p> <p></p> <p>was the middle child of three <span class="hlt">sisters</span>. Close in age to her younger <span class="hlt">sister</span>, Evelyn, she spent much of her childhood playing with Evelyn under the caring eye of her elder <span class="hlt">sister</span>, Elizabeth. Already as a young child, Rebecca showed an intuitive talent for painting and a love of flowers and nature. As she matured</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://arxiv.org/pdf/0807.0092v1','EPRINT'); return false;" href="http://arxiv.org/pdf/0807.0092v1"><span id="translatedtitle">Solar <span class="hlt">twins</span> in M67</span></a></p> <p><a target="_blank" href="http://www.osti.gov/eprints/">E-print Network</a></p> <p>L. Pasquini; K. Biazzo; P. Bonifacio; S. Randich; L. Bedin</p> <p>2008-07-01</p> <p>The discovery of true solar analogues is fundamental for a better understanding of the Sun and of the solar system. The open cluster M67 offers a unique opportunity to search for solar analogues because its chemical composition and age are very similar to those of the Sun. We analyze FLAMES spectra of a large number of M67 main sequence stars to identify solar analogues in this cluster.We first determine cluster members which are likely not binaries, by combining proper motions and radial velocity measurements. We concentrate our analysis on the determination of stellar effective temperature, using analyses of line-depth ratios and H$\\alpha$ wings, making a direct comparison with the solar spectrum obtained with the same instrument. We also compute the lithium abundance for all the stars.Ten stars have both the temperature derived by line-depth ratios and H$\\alpha$ wings within 100 K from the Sun. From these stars we derive, assuming a cluster reddening $E(B-V)=0.041$, the solar colour $(B-V)_\\odot=0.649\\pm0.016$ and a cluster distance modulus of 9.63. Five stars are most similar (within 60 K) to the Sun and candidates to be true solar <span class="hlt">twins</span>. These stars have also a low Li content, comparable to the photospheric abundance of the Sun, likely indicating a similar mixing evolution. We find several candidates for the best solar analogues ever. These stars are amenable to further spectroscopic investigations and planet search. The solar colours are determined with rather high accuracy with an independent method, as well as the cluster distance modulus.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.era.lib.ed.ac.uk/handle/1842/8681','EPRINT'); return false;" href="http://www.era.lib.ed.ac.uk/handle/1842/8681"><span id="translatedtitle">Personality development in monozygotic <span class="hlt">twins</span> of varying IQ discordance </span></a></p> <p><a target="_blank" href="http://www.osti.gov/eprints/">E-print Network</a></p> <p>Salomonsson, Sally</p> <p>2013-03-13</p> <p>The present study sought to investigate the personality-intelligence association by using longitudinal MZ <span class="hlt">twin</span> data to examine if intelligence and personality are developmentally linked. If <span class="hlt">twins</span> discordant for IQ in childhood grew up to differ more...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('//www.loc.gov/pictures/collection/hh/item/ut0346.photos.159541p/','SCIGOV-HHH'); return false;" href="//www.loc.gov/pictures/collection/hh/item/ut0346.photos.159541p/"><span id="translatedtitle">3. OVERALL VIEW OF <span class="hlt">TWIN</span> POTS RESERVOIR, LOOKING SOUTHEAST ...</span></a></p> <p><a target="_blank" href="http://www.loc.gov/pictures/collection/hh/">Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey</a></p> <p></p> <p></p> <p>3. OVERALL VIEW OF <span class="hlt">TWIN</span> POTS RESERVOIR, LOOKING SOUTHEAST - High Mountain Dams in Upalco Unit, <span class="hlt">Twin</span> Pots Dam, Ashley National Forest, 10.1 miles North of Mountain Home, Mountain Home, Duchesne County, UT</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/26382270','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/26382270"><span id="translatedtitle">Ethics in the management of conjoined <span class="hlt">twins</span>.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Spitz, Lewis</p> <p>2015-10-01</p> <p>In dealing with conjoined <span class="hlt">twins</span>, we have adopted a pragmatic approach in balancing what is possible, parental wishes and the likely outcome for the children. We believe that separation where feasible should be undertaken but appreciate that a few parents may wish their children to remain joined. The advice that we give balances the very real risks of surgery against the type of life the <span class="hlt">twins</span> will experience if they remain joined. In some types of union such as end to end ischiopagus, the <span class="hlt">twins</span> will never stand and will be bedridden. With other types of union, independent walking is not possible. Such limitations on living seem intolerable to us, but we have left the final decision to parents. PMID:26382270</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015MNRAS.453.1428J','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015MNRAS.453.1428J"><span id="translatedtitle">Climbing the cosmic ladder with stellar <span class="hlt">twins</span></span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Jofré, P.; Mädler, T.; Gilmore, G.; Casey, A. R.; Soubiran, C.; Worley, C.</p> <p>2015-10-01</p> <p>Distances to stars are key to revealing a three-dimensional view of the Milky Way, yet their determination is a major challenge in astronomy. Whilst the brightest nearby stars benefit from direct parallax measurements, fainter stars are subject of indirect determinations with uncertainties exceeding 30 per cent. We present an alternative approach to measuring distances using spectroscopically identified <span class="hlt">twin</span> stars. Given a star with known parallax, the distance to its <span class="hlt">twin</span> is assumed to be directly related to the difference in their apparent magnitudes. We found 175 <span class="hlt">twin</span> pairs from the science public archive of the European Southern Observatory (ESO) archives and report excellent agreement with Hipparcos parallaxes within 7.5 per cent. Most importantly, the accuracy of our results does not degrade with increasing stellar distance. With the ongoing collection of high-resolution stellar spectra, our method is well suited to complement Gaia.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/11684762','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/11684762"><span id="translatedtitle">[Human clone or a delayed <span class="hlt">twin</span>?].</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Szybalski, W</p> <p>2001-01-01</p> <p>Cloning is a natural mode of asexual reproduction for many organisms, which results in nearly identical copies of cells or organisms. In animals, including humans, identical <span class="hlt">twins</span> are an example of natural cloning. In the case of sheep, scientists succeeded to produce the "delayed" identical <span class="hlt">twin</span>. Dolly, of a mature animal by a rather complex and inefficient procedure. However, if this procedure is perfected, it will be useful to clone beloved pets and important laboratory animals. It will be much less suited for making (cloning) "delayed <span class="hlt">twin</span>" of mature persons because of high costs together with present experimental uncertainties. The only required regulation for human cloning is that somebody must be legally, including financially, responsible for the results of such novel reproductive technique. PMID:11684762</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/26624223','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/26624223"><span id="translatedtitle">TWSVR: Regression via <span class="hlt">Twin</span> Support Vector Machine.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Khemchandani, Reshma; Goyal, Keshav; Chandra, Suresh</p> <p>2016-02-01</p> <p>Taking motivation from <span class="hlt">Twin</span> Support Vector Machine (TWSVM) formulation, Peng (2010) attempted to propose <span class="hlt">Twin</span> Support Vector Regression (TSVR) where the regressor is obtained via solving a pair of quadratic programming problems (QPPs). In this paper we argue that TSVR formulation is not in the true spirit of TWSVM. Further, taking motivation from Bi and Bennett (2003), we propose an alternative approach to find a formulation for <span class="hlt">Twin</span> Support Vector Regression (TWSVR) which is in the true spirit of TWSVM. We show that our proposed TWSVR can be derived from TWSVM for an appropriately constructed classification problem. To check the efficacy of our proposed TWSVR we compare its performance with TSVR and classical Support Vector Regression(SVR) on various regression datasets. PMID:26624223</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/2676639','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/2676639"><span id="translatedtitle">Fetal weight estimation in <span class="hlt">twin</span> pregnancies.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Secher, N J; Tøttrup, A; Djursing, H; Weber, T</p> <p>1989-09-01</p> <p>In this study the fetal weight was estimated by ultrasound measurements of the biparietal (BPD) and abdominal diameters (AD) in 154 consecutive <span class="hlt">twin</span> pregnancies. In 80 <span class="hlt">twins</span> an attempt to estimate fetal weight was made 0-4 days before delivery (26% of all <span class="hlt">twins</span> examined). In 84% (67 infants) it was possible to estimate the fetal weight using the formula (0.0108 X AD1.72 X BPD0.99). 60% of the birth weights deviated less than 10% from the estimated fetal weight and 83% deviated less than 15%. The prediction error was nearly constant, expressed as percent of actual weight in the different weight groups (8.5-9.8%). In 19 LGA infants, 69% of the birth weights deviated less than 10% from the estimated fetal weight and 70% deviated less than 15%. PMID:2676639</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://arxiv.org/pdf/0910.5847.pdf','EPRINT'); return false;" href="http://arxiv.org/pdf/0910.5847.pdf"><span id="translatedtitle">Time, Topology and the <span class="hlt">Twin</span> Paradox</span></a></p> <p><a target="_blank" href="http://www.osti.gov/eprints/">E-print Network</a></p> <p>Luminet, J -P</p> <p>2009-01-01</p> <p>The <span class="hlt">twin</span> paradox is the best known thought experiment associated with Einstein's theory of relativity. An astronaut who makes a journey into space in a high-speed rocket will return home to find he has aged less than a <span class="hlt">twin</span> who stayed on Earth. This result appears puzzling, since the situation seems symmetrical, as the homebody <span class="hlt">twin</span> can be considered to have done the travelling with respect to the traveller. Hence it is called a "paradox". In fact, there is no contradiction and the apparent paradox has a simple resolution in Special Relativity with infinite flat space. In General Relativity (dealing with gravitational fields and curved space-time), or in a compact space such as the hypersphere or a multiply connected finite space, the paradox is more complicated, but its resolution provides new insights about the structure of spacetime and the limitations of the equivalence between inertial reference frames.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li class="active"><span>19</span></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_19 --> <div id="page_20" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li class="active"><span>20</span></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="381"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://arxiv.org/pdf/0910.5847v1','EPRINT'); return false;" href="http://arxiv.org/pdf/0910.5847v1"><span id="translatedtitle">Time, Topology and the <span class="hlt">Twin</span> Paradox</span></a></p> <p><a target="_blank" href="http://www.osti.gov/eprints/">E-print Network</a></p> <p>J. -P. Luminet</p> <p>2009-10-30</p> <p>The <span class="hlt">twin</span> paradox is the best known thought experiment associated with Einstein's theory of relativity. An astronaut who makes a journey into space in a high-speed rocket will return home to find he has aged less than a <span class="hlt">twin</span> who stayed on Earth. This result appears puzzling, since the situation seems symmetrical, as the homebody <span class="hlt">twin</span> can be considered to have done the travelling with respect to the traveller. Hence it is called a "paradox". In fact, there is no contradiction and the apparent paradox has a simple resolution in Special Relativity with infinite flat space. In General Relativity (dealing with gravitational fields and curved space-time), or in a compact space such as the hypersphere or a multiply connected finite space, the paradox is more complicated, but its resolution provides new insights about the structure of spacetime and the limitations of the equivalence between inertial reference frames.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2014MPLA...2950149G','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2014MPLA...2950149G"><span id="translatedtitle">The <span class="hlt">twin</span> paradox in the presence of gravity</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Gasperini, M.</p> <p>2014-09-01</p> <p>Conventional wisdom, based on kinematic (flat-space) intuition, tell us that a static <span class="hlt">twin</span> is aging faster than his traveling <span class="hlt">twin</span> brother. However, such a situation could be exactly inverted if the two <span class="hlt">twins</span> are embedded in an external gravitational field, and if the (dynamical) distortion of the spacetime geometry, due to gravity, is strong enough to compensate the kinematic effect of the relative <span class="hlt">twin</span> motion.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://arxiv.org/pdf/0909.5364v4','EPRINT'); return false;" href="http://arxiv.org/pdf/0909.5364v4"><span id="translatedtitle">The <span class="hlt">twin</span> paradox in a cosmological context</span></a></p> <p><a target="_blank" href="http://www.osti.gov/eprints/">E-print Network</a></p> <p>O. Gron; S. Braeck</p> <p>2011-09-20</p> <p>Recently Abramowicz and Bajtlik [ArXiv: 0905.2428 (2009)] have studied the <span class="hlt">twin</span> paradox in Schwarzschild spacetime. Considering circular motion they showed that the <span class="hlt">twin</span> with a non-vanishing 4-acceleration is older than his brother at the reunion and argued that in spaces that are asymptotically Minkowskian there exists an absolute standard of rest determining which <span class="hlt">twin</span> is oldest at the reunion. Here we show that with vertical motion in Schwarzschild spacetime the result is opposite: The <span class="hlt">twin</span> with a non-vanishing 4-acceleration is younger. We also deduce the existence of a new relativistic time effect, that there is either a time dilation or an increased rate of time associated with a clock moving in a rotating frame. This is in fact a first order effect in the velocity of the clock, and must be taken into account if the situation presented by Abramowicz and Bajtlik is described from the rotating rest frame of one of the <span class="hlt">twins</span>. Our analysis shows that this effect has a Machian character since the rotating state of a frame depends upon the motion of the cosmic matter due to the inertial dragging it causes. We argue that a consistent formulation and resolution of the <span class="hlt">twin</span> paradox makes use of the general principle of relativity and requires the introduction of an extended model of the Minkowski spacetime. In the extended model Minkowski spacetime is supplied with a cosmic shell of matter with radius equal to its own Schwarzschild radius, so that there is perfect inertial dragging inside the shell.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=printing+AND+Methods&pg=5&id=EJ772196','ERIC'); return false;" href="http://eric.ed.gov/?q=printing+AND+Methods&pg=5&id=EJ772196"><span id="translatedtitle">Sensitivity and Consistency of Maternal Writing Mediation to <span class="hlt">Twin</span> Kindergartners</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Aram, Dorit</p> <p>2007-01-01</p> <p>This study investigated whether mothers are responsive to their children's literacy level, thus employing different writing mediation styles with each <span class="hlt">twin</span> according to the child's level, or whether they possess a consistent style employed with both <span class="hlt">twins</span>. The sample included 28 sets of <span class="hlt">twin</span> kindergartners (56 children, M age = 68.89 months) and…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=Genetics&pg=3&id=EJ1008327','ERIC'); return false;" href="http://eric.ed.gov/?q=Genetics&pg=3&id=EJ1008327"><span id="translatedtitle">A Multivariate <span class="hlt">Twin</span> Study of Early Literacy in Japanese "Kana"</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Fujisawa, Keiko K.; Wadsworth, Sally J.; Kakihana, Shinichiro; Olson, Richard K.; DeFries, John C.; Byrne, Brian; Ando, Juko</p> <p>2013-01-01</p> <p>This first Japanese <span class="hlt">twin</span> study of early literacy development investigated the extent to which genetic and environmental factors influence individual differences in prereading skills in 238 pairs of <span class="hlt">twins</span> at 42 months of age. <span class="hlt">Twin</span> pairs were individually tested on measures of phonological awareness, "kana" letter name/sound knowledge, receptive…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=environmental+AND+problem+AND+test&pg=3&id=EJ754570','ERIC'); return false;" href="http://eric.ed.gov/?q=environmental+AND+problem+AND+test&pg=3&id=EJ754570"><span id="translatedtitle">Marital Conflict and Conduct Problems in Children of <span class="hlt">Twins</span></span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Harden, K. Paige; Turkheimer, Eric; Emery, Robert E.; D'Onofrio, Brian M.; Slutske, Wendy S.; Heath, Andrew C.; Martin, Nicholas G.</p> <p>2007-01-01</p> <p>The Children-of-<span class="hlt">Twins</span> design was used to test whether associations between marital conflict frequency and conduct problems can be replicated within the children of discordant <span class="hlt">twin</span> pairs. A sample of 2,051 children (age 14-39 years) of 1,045 <span class="hlt">twins</span> was used to estimate the genetic and environmental influences on marital conflict and determine…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.csusm.edu/fas/forms/rmsdocs/docs/hazardouswastegeneratorlabels.pdf','EPRINT'); return false;" href="http://www.csusm.edu/fas/forms/rmsdocs/docs/hazardouswastegeneratorlabels.pdf"><span id="translatedtitle">California State University 333 S. <span class="hlt">Twin</span> Oaks Valley Rd.</span></a></p> <p><a target="_blank" href="http://www.osti.gov/eprints/">E-print Network</a></p> <p>Puha, Amber</p> <p></p> <p>California State University San Marcos EH&S 333 S. <span class="hlt">Twin</span> Oaks Valley Rd. San Marcos, CA 92096-0001 (760) 750-4510 California State University San Marcos EH&S 333 S. <span class="hlt">Twin</span> Oaks Valley Rd. San Marcos, CA 92096-0001 (760) 750-4510 California State University San Marcos EH&S 333 S. <span class="hlt">Twin</span> Oaks Valley Rd. San</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=identical+AND+twins&pg=5&id=ED251245','ERIC'); return false;" href="http://eric.ed.gov/?q=identical+AND+twins&pg=5&id=ED251245"><span id="translatedtitle">Environmental Sources of Intelligence Differences among Separated Identical <span class="hlt">Twins</span>.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Franke, Richard H.; Paduch, Pamela J.</p> <p></p> <p>Since the time of Galton, high correlations have been noted in the IQ levels of identical <span class="hlt">twins</span>, with relationships for <span class="hlt">twins</span> reared in different families being only slightly lower than for <span class="hlt">twins</span> reared together. This evidence has been held to demonstrate that intellectual differences among individuals and among groups are largely determined by…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/24182348','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/24182348"><span id="translatedtitle">Fumarase deficiency in dichorionic diamniotic <span class="hlt">twins</span>.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Tregoning, Simone; Salter, Wendy; Thorburn, David R; Durkie, Miranda; Panayi, Maria; Wu, Joyce Y; Easterbrook, Aaron; Coman, David J</p> <p>2013-12-01</p> <p>Fumarase deficiency is a rare autosomal recessive inborn error of metabolism of the Krebs Tricarboxylic Acid cycle. A heavy neurological disease burden is imparted by fumarase deficiency, commonly manifesting as microcephaly, dystonia, global developmental delay, seizures, and lethality in the infantile period. Heterozygous carriers also carry an increased risk of developing hereditary leiomyomatosis and renal cell carcinoma. We describe a non-consanguineous family in whom a dichorionic diamniotic <span class="hlt">twin</span> pregnancy resulted in <span class="hlt">twin</span> boys with fumarase deficiency proven at the biochemical, enzymatic, and molecular levels. Their clinical phenotype included hepatic involvement. A novel mutation in the fumarate hydratase gene was identified in this family. PMID:24182348</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/25576578','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/25576578"><span id="translatedtitle"><span class="hlt">Twin</span> Support Vector Machine for Clustering.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Wang, Zhen; Shao, Yuan-Hai; Bai, Lan; Deng, Nai-Yang</p> <p>2015-10-01</p> <p>The <span class="hlt">twin</span> support vector machine (TWSVM) is one of the powerful classification methods. In this brief, a TWSVM-type clustering method, called <span class="hlt">twin</span> support vector clustering (TWSVC), is proposed. Our TWSVC includes both linear and nonlinear versions. It determines k cluster center planes by solving a series of quadratic programming problems. To make TWSVC more efficient and stable, an initialization algorithm based on the nearest neighbor graph is also suggested. The experimental results on several benchmark data sets have shown a comparable performance of our TWSVC. PMID:25576578</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/servlets/purl/1028800','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/servlets/purl/1028800"><span id="translatedtitle">Epicyclic <span class="hlt">Twin</span>-Helix Ionization Cooling Simulations</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Vasiliy Morozov, Yaroslav Derbenev, A. Afanaciev, R.P. Johnson</p> <p>2011-04-01</p> <p>Parametric-resonance Ionization Cooling (PIC) is proposed as the final 6D cooling stage of a highluminosity muon collider. For the implementation of PIC, we earlier developed an epicyclic <span class="hlt">twin</span>-helix channel with correlated behavior of the horizontal and vertical betatron motions and dispersion. We now insert absorber plates with short energy-recovering units located next to them at the appropriate locations in the <span class="hlt">twin</span>-helix channel. We first demonstrate conventional ionization cooling in such a system with the optics uncorrelated. We then adjust the correlated optics state and induce a parametric resonance to study ionization cooling under the resonant condition.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/26601729','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/26601729"><span id="translatedtitle">Conjoined <span class="hlt">twins</span>: scientific cinema and Pavlovian physiology.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Krementsov, Nikolai</p> <p>2015-01-01</p> <p>Through the lens of a 1957 documentary film, "Neural and humoral factors in the regulation of bodily functions (research on conjoined <span class="hlt">twins</span>)," produced by the USSR Academy of Medical Sciences, this essay traces the entwined histories of Soviet physiology, studies of conjoined <span class="hlt">twins</span> and scientific cinema. It examines the role of Ivan Pavlov and his students, including Leonid Voskresenkii, Dmitrii Fursikov and Petr Anokhin, in the development of "scientific film" as a particular cinematographic genre in Soviet Russia and explores numerous puzzles hidden behind the film's striking visuals. PMID:26601729</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/20136360','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/20136360"><span id="translatedtitle">Classical <span class="hlt">twin</span> design in modern pharmacogenomics studies.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Rahmio?lu, Nilüfer; Ahmadi, Kourosh R</p> <p>2010-02-01</p> <p>Response to medication is highly variable, unpredictable and, at times, may be fatal. All drugs are more effective in certain groups of the population while showing no or minimal benefit in other groups. Although the current data on the subject are piecemeal, anecdotal evidence suggests that, in line with other common multifactorial traits, a myriad of genomic as well as environmental factors underpin population variability in drug response. Pharmacogenomics is the study of how variations in the human genome affect the variability in response to medication. Efforts to personalize treatment based on results from pharmacogenomics studies have the potential to increase efficacy, lower the overall cost of treatment, and decrease the incidence of adverse drug reactions, and are one of the major challenges of the modern era. The classical <span class="hlt">twin</span> design has traditionally been used to assess the relative contribution of genetic and environmental factors to population variation in common, complex phenotypes, including drug response. <span class="hlt">Twins</span> are not commonly regarded as providing the optimal design in genomic studies. However, we argue that, through their precise 'matching' for confounding variables (age, sex, cohort and common environmental effects), their amenability to numerous nonclassical study designs (genome-wide association studies or the role of epigenetic factors), and the availability of large, established registries worldwide, the <span class="hlt">twin</span> model represents a flexible study design for systems-biology studies of drug response in humans. In this review, we describe the 'classical <span class="hlt">twin</span> model' and its application in traditional pharmacogenetics studies, discuss the value of the <span class="hlt">twin</span> design in the modern systems biology era, and highlight the potential of existing <span class="hlt">twin</span> registries in formulating future strategies in pharmacogenomics research. We argue that the usefulness of this design goes beyond its traditional applications. Moreover, the flexibility of the model in concert with the amenability of large, established registries of <span class="hlt">twins</span> worldwide to the collecting of new phenotypes will mean that the study of identical and nonidentical <span class="hlt">twins</span> will play a considerable role in shaping our understanding of the important factors that underpin population variability in common, complex phenotypes, including response to medication. PMID:20136360</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2014EAS....67..383M','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2014EAS....67..383M"><span id="translatedtitle">Solar <span class="hlt">twins</span> and siblings in spectroscopic archives</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Mahdi, D.; Soubiran, C.; Blanco-Cuaresma, S.</p> <p>2014-07-01</p> <p>Solar <span class="hlt">twins</span> are stars that replicate the solar astrophysical properties. They represent natural candidates for harboring planetary systems similar to ours. Solar siblings are stars which were born in the same cluster than the Sun. They may differ from the Sun by their mass and radius, but they have the same age, the same chemical composition, and similar spatial velocities. Solar <span class="hlt">twins</span> and siblings may have formed in the same conditions as the Sun, and thus they may give some clues on where and how the Sun formed in our Galaxy. In this study, we search the closest solar <span class="hlt">twins</span> among thousands of solar type stars observed at high spectral resolution over the full optical range. The spectra are directly compared to solar ones observed by reflection on asteroids or the Moon with the same instrument. This purely differential method, based on the reduced ?2, is independant of any model. We applied it to a selection of ˜17700 spectra of ˜3500 different stars from the ELODIE archive. The star HD 146233 (18 Sco) keeps its status of the closest solar <span class="hlt">twin</span>. The second closest star is the known solar <span class="hlt">twin</span> HD 138573. Some other stars among the top twenty best stars have never been studied before, like HD 168009, HD 056124, and HD 029150. Atmospheric parameters of the top twenty solar <span class="hlt">twins</span> were determined with the iSpec code. Their effective temperatures and gravities are found to be within 100 K and 0.1 dex from those of the Sun, respectively. We find the metallicity of the <span class="hlt">twins</span> to be higher by 0.05 dex on average than that of the Sun. We derived the chemical abundances for the 200 closest solar <span class="hlt">twins</span> in a line by line differential basis relative to the Sun. The absorption lines used in this study come from a rigorous analysis of 670 lines measured in our 14 solar spectra. We find several stars with all abundances within 0.01 dex from those of the Sun. Several of them fall on the Yonsei-Yale theoritical isochrone of solar age and metallicity. Thus they could have been formed in the same cluster as the Sun.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/25639144','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/25639144"><span id="translatedtitle">Seeing double: annular diaper rash in <span class="hlt">twins</span>.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Sommer, Lacy L; Manders, Steven M</p> <p>2015-01-01</p> <p>We report a case of dichorionic, diamniotic <span class="hlt">twins</span> who developed similar erythematous, annular, erosive plaques in the inguinal folds in the first few weeks of life that were refractory to topical antifungals and oral antibiotics. The <span class="hlt">twins</span> were found to have high transaminase levels, antinuclear antibody positivity, and anti-SSS/Ro) and anti-SSB/La autoantibodies. The rash resolved without scarring by 7 months of age with the use of low-potency topical corticosteroids. We suggest that physicians consider neonatal lupus erythematosus in neonates with atypical eruptions occurring in sun-protected skin. PMID:25639144</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2002EJPh...23..277U','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2002EJPh...23..277U"><span id="translatedtitle">The <span class="hlt">twin</span> paradox and space topology</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Uzan, Jean-Philippe; Luminet, Jean-Pierre; Lehoucq, Roland; Peter, Patrick</p> <p>2002-05-01</p> <p>If space is compact, then a traveller <span class="hlt">twin</span> can leave Earth, travel back home without changing direction and find her sedentary <span class="hlt">twin</span> older than herself. We show that the asymmetry between their spacetime trajectories lies in a topological invariant of their spatial geodesics, namely the homotopy class. This illustrates how the spacetime symmetry invariance group, although valid locally, is broken down globally as soon as some points of space are identified. As a consequence, any non-trivial space topology defines preferred inertial frames along which the proper time is longer than along any other one.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://arxiv.org/pdf/1504.06186v1','EPRINT'); return false;" href="http://arxiv.org/pdf/1504.06186v1"><span id="translatedtitle">Two New Variations on the <span class="hlt">Twin</span> Pseudoparadox</span></a></p> <p><a target="_blank" href="http://www.osti.gov/eprints/">E-print Network</a></p> <p>Jean Marc Levy Leblond</p> <p>2015-03-20</p> <p>Two new scenarios are proposed which generalize the standard story leading to the pseudoparadox of the Einsteinian relativistic <span class="hlt">twins</span>, thereby enabling some deeper understanding. First, the fable by Aesop 'The Hare and the Tortoise' is considered in the light of Einsteinian chronogeometry. It is then shown that the Hare, while arriving later than the Tortoise, may still be the winner of the race (or at least may consider itself to be). Second, the situation is considered where the <span class="hlt">twin</span> initially left at home decides to catch up his brother during his travel. Can they meet so that they may celebrate a common anniversary and recover the same age?</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4017435','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4017435"><span id="translatedtitle">Successful <span class="hlt">twin</span> pregnancy in a patient with ulcerative colitis using azathoprine during conception</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Casella, Giovanni; Villanacci, Vincenzo; Antonelli, Elisabetta; Di Bella, Camillo; Baldini, Vittorio; Nejad, Mohammad Rostami; Bassotti, Gabrio</p> <p>2011-01-01</p> <p>Inflammatory bowel disease (IBD) frequently affects young patients of childbearing age. Treatments for inflammatory bowel disease include immunosuppressive, cytotoxic and surgical therapies. Azathioprine is frequently used to treat patients with steroid dependent IBD. We report the case of a patient with ulcerative colitis, treated with azathioprine prior to conception and during the subsequent pregnancy with the subsequent successful delivery of <span class="hlt">healthy</span> <span class="hlt">twins</span>. Although some potential risks indeed exist, the use of AZA may not be harmful to the mother or the fetus in many instances. PMID:24834187</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/8548823','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/8548823"><span id="translatedtitle">Separation of <span class="hlt">sister</span> chromatids in mitosis requires the Drosophila pimples product, a protein degraded after the metaphase/anaphase transition.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Stratmann, R; Lehner, C F</p> <p>1996-01-12</p> <p>Mutations in the Drosophila genes pimples and three rows result in a defect of <span class="hlt">sister</span> chromatid separation during mitosis. As a consequence, cytokinesis is also defective. However, cell cycle progression including the mitotic degradation of cyclins A and B is not blocked by the failure of <span class="hlt">sister</span> chromatid separation, and as a result, metaphase chromosomes with twice the normal number of chromosome arms still connected in the centromeric region are observed in the following mitosis, pimples encodes a novel protein that is rapidly degraded in mitosis. Our observations suggest that Pimples and Three rows act during mitosis to release the cohesion between <span class="hlt">sister</span> centromeres. PMID:8548823</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/25828210','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/25828210"><span id="translatedtitle">The <span class="hlt">Healthy</span> Kids, <span class="hlt">Healthy</span> Communities national program.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Strunk, Sarah L; Bussel, Jamie B</p> <p>2015-01-01</p> <p>In 2007, the Robert Wood Johnson Foundation announced a bold and unprecedented commitment of $500 million to reverse the epidemic of childhood obesity by 2015, especially in communities at greatest risk based on income, race, ethnicity, and geographic location. To support this work, the foundation launched an array of complementary initiatives aimed at building the evidence base, testing advocacy approaches, and supporting on-the-ground action to reverse the childhood obesity epidemic. <span class="hlt">Healthy</span> Kids, <span class="hlt">Healthy</span> Communities (HKHC), a 5-year $33.4 million national program, was one of the foundation's earliest such investments. Building on previous successes, HKHC was designed to address the policies, systems, and environments that make it easier for low-income children and their families to engage in physical activity and play and to access <span class="hlt">healthy</span> food in their communities. As part of its strategy, the Robert Wood Johnson Foundation funded 50 multidisciplinary partnerships across the country, with a special focus on 15 southern states where health disparities were most significant. The selection of Active Living By Design to lead the HKHC National Program Office and Transtria, LLC, to lead the evaluation leveraged these organizations' experience in addressing the systemic issues that contribute to physical inactivity and unhealthy eating, using a broader <span class="hlt">healthy</span> community lens. Key elements of HKHC included funding, ongoing technical assistance and consultation, a peer learning network, and participatory evaluation. The successes of the HKHC grant program are well documented in this journal as well as through case studies and case reports, spotlights, leadership profiles, and other products available at www.healthykidshealthycommunities.org and http://www.transtria.com/hkhc.php. PMID:25828210</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li class="active"><span>20</span></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_20 --> <div id="page_21" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li class="active"><span>21</span></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="401"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015EPSC...10...69K','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015EPSC...10...69K"><span id="translatedtitle">Planets and satellites: tectonic <span class="hlt">twins</span></span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Kochemasov, G. G.</p> <p>2015-10-01</p> <p>There are only three solid planet-satellite pairs in the Solar system: Earth -Moon, Mars -Phobos, Pluto - Charon. For the first two pairs tectonic analogies were shown and explained by moving them in one circumsolar orbit. As it is known from the wave planetology [3, 4, 6], "orbits make structures". For the third pair the same was stated as a prediction based on this fundamental rule. Global tectonic forms of wave origin appear in cosmic bodies because they move in keplerian orbits with periodically changing accelerations. Warping bodies waves have a stationary character and obeying wave harmonics lengths. Starting from the fundamental 2?R-long wave 1 making the ubiquitous tectonic dichotomy (two-face appearance) warping wave lengths descend along harmonics. Very prominent along with the wave 1 are waves 2 responsible for tectonic sectoring superimposed on the wave 1 segments. Practically all bodies have traces of shorter waves making numerous polygons (rings) often confused with impact craters. Earth and the Moon moving in one circumsolar orbit both are distorted by wave 1, wave 2 and wave 4 features aligned along extent tectonic lines [4, 5]. At Earth they are: Pacific Ocean (2?R-structure) and Indian Ocean (?R-structure) from both ends with Malay Archipelago (?R/4-structure) in the middle. At Moon they are: Procellarum Ocean (2?R) and SPA Basin (?R) from ends and Mare Orientale (?R/4) in the middle. A regular disposition is surprising. Both Oceans and Basin occur on opposite hemispheres, lying in the middle both ring structures occur in the boundary between two hemispheres and are of the same relative size. These triads stretch along lines parallel to the equator (Earth) and with the angle about 30 degrees to it (Moon) indicating at a different orientation of the rotation axes in the ancient time [2]. On the whole, one could speak about a "lunar mould" of Earth [5] (Fig. 1-3). Another tectonic <span class="hlt">twin</span> is the pair Mars -Phobos. Both bodies sharing one circumsolar orbit, twice as long as the Earth -Moon orbit, acquire slightly oblong ellipsoidal shape (Fig. 4, 5). Very pronounced on both so much different in size and composition bodies the deepest basins - Hellas and Stickney (sectoral ?R-structures) are comparable features. The structural unity is predicted also for the third solid body pair -Pluto -Charon.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/biblio/22391093','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/biblio/22391093"><span id="translatedtitle">Investigations on the mechanical behavior of nanowires with <span class="hlt">twin</span> boundaries by atomistic simulations</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Tian, Xia</p> <p>2015-03-10</p> <p>Atomistic simulations are used to study the deformation behavior of <span class="hlt">twinned</span> Cu nanowires with a <111> growth orientation under tension. Due to the existence of the <span class="hlt">twin</span> boundaries, the strength of the <span class="hlt">twinned</span> nanowires is higher than that of the <span class="hlt">twin</span>-free nanowire and the yielding stress of <span class="hlt">twinned</span> nanowires is inversely proportional to the spacings of the <span class="hlt">twin</span> boundaries. Moreover, The ductility of the <span class="hlt">twin</span>-free nanowire is the highest of all and it grows with the increasing spacings of the <span class="hlt">twin</span> boundaries for <span class="hlt">twinned</span> nanowires. Besides, we find that the <span class="hlt">twin</span> boundaries can be served as dislocation sources as well as the free surfaces and grain boundaries.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=estimated&pg=6&id=EJ1040557','ERIC'); return false;" href="http://eric.ed.gov/?q=estimated&pg=6&id=EJ1040557"><span id="translatedtitle">Late Language Emergence in 24-Month-Old <span class="hlt">Twins</span>: Heritable and Increased Risk for Late Language Emergence in <span class="hlt">Twins</span></span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Rice, Mabel L.; Zubrick, Stephen R.; Taylor, Catherine L.; Gayán, Javier; Bontempo, Daniel E.</p> <p>2014-01-01</p> <p>Purpose: This study investigated the etiology of late language emergence (LLE) in 24-month-old <span class="hlt">twins</span>, considering possible <span class="hlt">twinning</span>, zygosity, gender, and heritability effects for vocabulary and grammar phenotypes. Method: A population-based sample of 473 <span class="hlt">twin</span> pairs participated. Multilevel modeling estimated means and variances of vocabulary and…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://familydoctor.org/familydoctor/en/prevention-wellness/staying-healthy/healthy-living/preventive-services-for-healthy-living.printerview.all.html','NIH-MEDLINEPLUS'); return false;" href="http://familydoctor.org/familydoctor/en/prevention-wellness/staying-healthy/healthy-living/preventive-services-for-healthy-living.printerview.all.html"><span id="translatedtitle">Preventive Services for <span class="hlt">Healthy</span> Living</span></a></p> <p><a target="_blank" href="http://medlineplus.gov/">MedlinePLUS</a></p> <p></p> <p></p> <p>MENU Return to Web version Preventive Services for <span class="hlt">Healthy</span> Living Preventive Services for <span class="hlt">Healthy</span> Living How can my doctor help me stay <span class="hlt">healthy</span>? ... preventive service"? A preventive service might be a test, or it might be advice from your doctor. ...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/biblio/22163174','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/biblio/22163174"><span id="translatedtitle"><span class="hlt">Twin</span> nucleation and migration in FeCr single crystals</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Patriarca, L.; Abuzaid, Wael; Sehitoglu, Huseyin; Maier, Hans J.; Chumlyakov, Y.</p> <p>2013-01-15</p> <p>Tension and compression experiments were conducted on body-centered cubic Fe -47.8 at pct. Cr single crystals. The critical resolved shear stress (CRSS) magnitudes for slip nucleation, <span class="hlt">twin</span> nucleation and <span class="hlt">twin</span> migration were established. We show that the nucleation of slip occurs at a CRSS of about 88 MPa, while <span class="hlt">twinning</span> nucleates at a CRSS of about 191 MPa with an associated load drop. Following <span class="hlt">twin</span> nucleation, <span class="hlt">twin</span> migration proceeds at a CRSS that is lower than the initiation stress ( Almost-Equal-To 114-153 MPa). The experimental results of the nucleation stresses indicate that the Schmid law holds to a first approximation for the slip and <span class="hlt">twin</span> nucleation cases, but to a lesser extent for <span class="hlt">twin</span> migration particularly when considerable slip strains preceded <span class="hlt">twinning</span>. The CRSSs were determined experimentally using digital image correlation (DIC) in conjunction with electron back scattering diffraction (EBSD). The DIC measurements enabled pinpointing the precise stress on the stress-strain curves where <span class="hlt">twins</span> or slip were activated. The crystal orientations were obtained using EBSD and used to determine the activated <span class="hlt">twin</span> and slip systems through trace analysis. - Highlights: Black-Right-Pointing-Pointer Digital image correlation allows to capture slip/<span class="hlt">twin</span> initiation for bcc FeCr. Black-Right-Pointing-Pointer Crystal orientations from EBSD allow slip/<span class="hlt">twin</span> system indexing. Black-Right-Pointing-Pointer Nucleation of slip always precedes <span class="hlt">twinning</span>. Black-Right-Pointing-Pointer <span class="hlt">Twin</span> growth is sustained with a lower stress than required for nucleation. Black-Right-Pointing-Pointer <span class="hlt">Twin</span>-slip interactions provide high hardening at the onset of plasticity.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/biblio/6052504','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/biblio/6052504"><span id="translatedtitle">Frequency of <span class="hlt">sister</span> chromatid exchange in peripheral lymphocytes of male pesticide applicators</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Rupa, D.S. ); Reddy, P.P. ); Sreemannarayana, K. ); Reddi, O.S. )</p> <p>1991-01-01</p> <p>In the present study 61 male pesticide applicators who worked in cotton fields and regularly sprayed pesticides such as DDT, BHC, endosulfan, malathion, methyl parathion, phosphamidon, dimethoate, monocrotophos, quinalphos fenvelrate, and cypermethrin were analyzed for <span class="hlt">sister</span> chromatid exchanges, mitotic index, and cell cycle kinetics in peripheral lymphocytes. Subjects who handled pesticides were non-smokers and teetotalers and the data were compared with the matched control group. Statistical analysis revealed that the frequency of <span class="hlt">sister</span> chromatid exchanges was significantly higher among the pesticide applicators at all the durations of exposure when compared to controls. Subjects exposed to pesticides also showed cell cycle delay and decrease in mitotic index when compared to the control group.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://kidshealth.org/teen/school_jobs/college/dining_hall.html','NIH-MEDLINEPLUS'); return false;" href="http://kidshealth.org/teen/school_jobs/college/dining_hall.html"><span id="translatedtitle"><span class="hlt">Healthy</span> Dining Hall Eating</span></a></p> <p><a target="_blank" href="http://medlineplus.gov/">MedlinePLUS</a></p> <p></p> <p></p> <p>... for Parents for Kids for Teens Teens Home Body Mind Sexual Health Food & Fitness Diseases & Conditions Infections Q& ... with <span class="hlt">healthy</span> foods will help fuel both your body and your mind. Reviewed by: Mary L. Gavin, MD Date reviewed: ...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www1.paho.org/English/DD/PIN/whd03_monica.pdf','NIH-MEDLINEPLUS'); return false;" href="http://www1.paho.org/English/DD/PIN/whd03_monica.pdf"><span id="translatedtitle"><span class="hlt">Healthy</span> Environments for Children</span></a></p> <p><a target="_blank" href="http://medlineplus.gov/">MedlinePLUS</a></p> <p></p> <p></p> <p>... THEY NEED CARE AND AFFECTION IN A <span class="hlt">HEALTHY</span> ENVIRONMENT! ...AT SCHOOL... 2 ...AT HOME... ...EVEN IN THEIR ... SOLUTIONS FOR ALL THESE PROBLEMS... BY PROTECTING THE ENVIRONMENT, ESPECIALLY RIVERS AND FORESTS, WE CAN IMPROVE THE ...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.strokeassociation.org/STROKEORG/LifeAfterStroke/HealthyLivingAfterStroke/Healthy-Living-After-Stroke_UCM_308568_SubHomePage.jsp','NIH-MEDLINEPLUS'); return false;" href="http://www.strokeassociation.org/STROKEORG/LifeAfterStroke/HealthyLivingAfterStroke/Healthy-Living-After-Stroke_UCM_308568_SubHomePage.jsp"><span id="translatedtitle"><span class="hlt">Healthy</span> Living after Stroke</span></a></p> <p><a target="_blank" href="http://medlineplus.gov/">MedlinePLUS</a></p> <p></p> <p></p> <p>... Good nutrition is one way to reduce your risk of having another stroke. Find tips for shopping, how to prepare <span class="hlt">healthy</span> meals and lots of free recipes. Physical Activity Though limited physical abilities may ... Following Doctor's Orders Following ...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.niams.nih.gov/Health_Info/Kids/healthy_bones.asp','NIH-MEDLINEPLUS'); return false;" href="http://www.niams.nih.gov/Health_Info/Kids/healthy_bones.asp"><span id="translatedtitle"><span class="hlt">Healthy</span> Bones Matter</span></a></p> <p><a target="_blank" href="http://medlineplus.gov/">MedlinePLUS</a></p> <p></p> <p></p> <p>... keep my bones more <span class="hlt">healthy</span>? Definitions What can go wrong? Reprinted from The Surgeon General’s Report on ... women who don’t smoke, and they often go through menopause earlier. Smokers also may absorb less ...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.niams.nih.gov/Health_Info/Kids/healthy_muscles.asp','NIH-MEDLINEPLUS'); return false;" href="http://www.niams.nih.gov/Health_Info/Kids/healthy_muscles.asp"><span id="translatedtitle"><span class="hlt">Healthy</span> Muscles Matter</span></a></p> <p><a target="_blank" href="http://medlineplus.gov/">MedlinePLUS</a></p> <p></p> <p></p> <p>... keep my muscles more <span class="hlt">healthy</span>? Definitions What can go wrong? Injuries Almost everyone has had sore muscles ... If you have been inactive, “start low and go slow” by gradually increasing how often and how ...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.heart.org/HEARTORG/Conditions/More/ToolsForYourHeartHealth/Healthy-Heart-Quizzes_UCM_304635_Article.jsp','NIH-MEDLINEPLUS'); return false;" href="http://www.heart.org/HEARTORG/Conditions/More/ToolsForYourHeartHealth/Healthy-Heart-Quizzes_UCM_304635_Article.jsp"><span id="translatedtitle"><span class="hlt">Healthy</span> Heart Quizzes</span></a></p> <p><a target="_blank" href="http://medlineplus.gov/">MedlinePLUS</a></p> <p></p> <p></p> <p>... More <span class="hlt">Healthy</span> Heart Quizzes Updated:Feb 26,2015 Cardiovascular Conditions • Conditions Home • Arrhythmia and Atrial Fibrillation • Cardiac Arrest • Cardiac Rehab • Cardiomyopathy • Cardiovascular Conditions of Childhood • Cholesterol • Congenital Heart Defects • Diabetes • ...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://womenshealth.gov/aging/sexual-health/','NIH-MEDLINEPLUS'); return false;" href="http://womenshealth.gov/aging/sexual-health/"><span id="translatedtitle"><span class="hlt">Healthy</span> Aging -- Sexual Health</span></a></p> <p><a target="_blank" href="http://medlineplus.gov/">MedlinePLUS</a></p> <p></p> <p></p> <p>... <span class="hlt">Healthy</span> Aging This information in Spanish ( en español ) Sexual health More information on sexual health Many older women ... Protecting yourself Return to top More information on Sexual health Read more from womenshealth.gov Sexually Transmitted Infections ...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/biblio/1002702','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/biblio/1002702"><span id="translatedtitle">Nanoscale <span class="hlt">twinning</span>-induced elastic strengthening in silicon carbide nanowires</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Lin, Z.J.; Wang, Lin; Zhang, Jianzhong; Guo, Xiang-Yun; Yang, Wenge; Mao, Ho-Kwang; Zhao, Yusheng</p> <p>2010-10-22</p> <p>Compressibility of periodically <span class="hlt">twinned</span> silicon carbide nanowires is studied using in situ high pressure X-ray diffraction. <span class="hlt">Twinned</span> SiC nanowires displayed a bulk modulus of 316 GPa, {approx}20-40% higher than previously reported values for SiC of other morphologies. This finding provides direct evidence of a significant effect of <span class="hlt">twinned</span> structures on the elastic properties of SiC on the nano scale and supports previous molecular dynamics simulations of <span class="hlt">twin</span> boundary/stacking fault-induced strengthening. Both experiments and simulations indicate that nanoscale <span class="hlt">twinning</span> is an effective pathway by which to tailor the mechanical properties of nanostructures.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/25725685','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/25725685"><span id="translatedtitle">Conjoined <span class="hlt">twins</span> with single heart and liver - a case report.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Nahar, N; Khan, N; Islam, S M; Chakraborty, R K; Rima, S Z; Ara, R; Mahmood, S; Hossain, G A</p> <p>2015-01-01</p> <p><span class="hlt">Twin</span> pregnancy is common but conjoined <span class="hlt">twins</span> are an extremely rare congenital malformation without any known genetic predisposition. The incidence of conjoined <span class="hlt">twins</span> is estimated to be around 1 in 250,000 live births with a female predilection. We presented an extremely rare case of abdomino-thoracopagus with single heart and liver. In this paper, the imaging of conjoined <span class="hlt">twins</span> both antenatally and postnatally is reviewed, in particular taking into consideration recent advances with gray scale and color Doppler ultrasound. This case is of particular interest because of the rarity of abdomino-thoracopagus <span class="hlt">twins</span> with single heart and liver, in literature. PMID:25725685</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/biblio/1065285','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/biblio/1065285"><span id="translatedtitle">Nanoscale <span class="hlt">twinning</span>-induced elastic strength in silicon carbite nanowires</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Lin, Zhijun; Wang, Lin; Zhang, Jianzhong; Guo, Xiang-Yun; Yang, Wenge; Mao, Ho-kwang; Zhao, Yusheng</p> <p>2010-07-23</p> <p>Compressibility of periodically <span class="hlt">twinned</span> silicon carbide nanowires is studied using in situ high pressure X-ray diffraction. <span class="hlt">Twinned</span> SiC nanowires displayed a bulk modulus of 316 GPa, ~20–40% higher than previously reported values for SiC of other morphologies. This finding provides direct evidence of a significant effect of <span class="hlt">twinned</span> structures on the elastic properties of SiC on the nano scale and supports previous molecular dynamics simulations of <span class="hlt">twin</span> boundary/stacking fault-induced strengthening. Both experiments and simulations indicate that nanoscale <span class="hlt">twinning</span> is an effective pathway by which to tailor the mechanical properties of nanostructures.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/11869485','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/11869485"><span id="translatedtitle">Potential bias regarding birth weight in historical and contemporary <span class="hlt">twin</span> data bases.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Sadrzadeh, S; Treloar, S A; van Baal, G C; Lambalk, C B</p> <p>2001-10-01</p> <p>In this study we examine the hypothesis that monozygotic (MZ) <span class="hlt">twins</span> in historical databases are less discordant for birth weight due to negative selection of severely discordant MZ <span class="hlt">twins</span>. Furthermore, we test the hypothesis that MZ <span class="hlt">twins</span> are less discordant for birth weight when comparing a volunteer based <span class="hlt">twin</span> registry with a population based <span class="hlt">twin</span> registry, due to selective registration. Data were available on 3927 <span class="hlt">twin</span> pairs from the volunteer Australian <span class="hlt">Twin</span> Registry born before 1964, 3059 volunteer <span class="hlt">twin</span> pairs from the Netherlands <span class="hlt">Twin</span> Register born 1987-1989 and 454 Belgian <span class="hlt">twin</span> pairs from The East Flanders Prospective <span class="hlt">Twin</span> Survey born 1987-1989. Intrapair relative birth weight differences (RBWD) were computed for MZ and dizygotic (DZ) <span class="hlt">twins</span> from each <span class="hlt">twin</span> registry. Comparing birth weight differences between MZ and DZ <span class="hlt">twins</span> provides support for the hypothesis that MZ <span class="hlt">twins</span> are subject to a negative selection in historical databases. Furthermore, Australian MZ <span class="hlt">twins</span> have a lower RBWD compared to Dutch MZ <span class="hlt">twins</span> when corrected for the RBWD of Australian and Dutch DZ <span class="hlt">twins</span>, indicating circumstances which only affect MZ <span class="hlt">twins</span>. Our hypothesis that MZ <span class="hlt">twins</span> are less discordant for birth weight in a volunteer based <span class="hlt">twin</span> registry compared to a population based <span class="hlt">twin</span> registry had to be rejected. We suggest that investigators using historical databases to test the fetal origins hypothesis should be aware of this increased likelihood of selective exclusion of individuals with extreme morphometric parameters at time of birth. PMID:11869485</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://kuscholarworks.ku.edu/handle/1808/12948','EPRINT'); return false;" href="http://kuscholarworks.ku.edu/handle/1808/12948"><span id="translatedtitle">A Seamless Garment of Eco-Justice: Green <span class="hlt">Sisters</span> in Kansas</span></a></p> <p><a target="_blank" href="http://www.osti.gov/eprints/">E-print Network</a></p> <p>Myslivy, Rachel Ann Boeckman</p> <p>2013-12-31</p> <p>provides a solid platform for an environmental ethic. Twentieth-century theologians Pierre Teilhard de 5 Chardin (1891-1955) and Thomas Berry (1914-2009) presented compelling responses, walking the fine line between visionary and heretic. Teilhard..., influenced by such figures as Thomas Berry, Pierre Teilhard de Chardin, Ilia Delio, 13th century mystics, St. Francis of Assisi, and others. Many interviews reflect a deep sense of rootedness in the landscape. Often, <span class="hlt">sisters</span> expressed extreme frustration...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3900763','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3900763"><span id="translatedtitle">An overview of human handedness in <span class="hlt">twins</span></span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Ooki, Syuichi</p> <p>2014-01-01</p> <p>There has been a long-standing debate on the complex correlation between the development of human hand preference and brain lateralization. Handedness, used as a proxy for cerebral lateralization, is a topic of considerable importance because of its potential to reveal the mechanisms of the underlying pathophysiology of problems related to brain development or cognitive systems. <span class="hlt">Twin</span> studies, which represent an important method of research in human genetics, would provide valuable suggestions to the studies on the relationship between lateralization and cognitive systems. Many studies have been performed using <span class="hlt">twin</span> subjects; however, the results are inconsistent, partly because of sample size, background assumptions, data limits or inaccuracies, incorrect zygosity classification, and/or lack of birth histories. In summary, within the long history and large number of <span class="hlt">twin</span> studies performed on handedness, a surprisingly large number of controversial findings have been reported, suggesting the complicated nature of this phenotype. In this mini review, the wide variety of <span class="hlt">twin</span> studies on human handedness performed to date are introduced. PMID:24478742</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.catalogs.umn.edu/documents/UMNTCGradCCE.pdf','EPRINT'); return false;" href="http://www.catalogs.umn.edu/documents/UMNTCGradCCE.pdf"><span id="translatedtitle"><span class="hlt">Twin</span> Cities Campus Addiction Studies Postbaccalaureate Certificate</span></a></p> <p><a target="_blank" href="http://www.osti.gov/eprints/">E-print Network</a></p> <p>Minnesota, University of</p> <p></p> <p>· · · · · · <span class="hlt">Twin</span> Cities Campus Addiction Studies Postbaccalaureate Certificate CCE Addiction: Addiction Studies, Degree and Certificate Programs, 20 Ruttan Hall, 1994 Buford Avenue, St. Paul, MN 55108 (612-624-4000; fax: 612- 625-1511) Email: cceinfo@umn.edu Website: http://www.cce.umn.edu/Addiction</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li class="active"><span>21</span></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_21 --> <div id="page_22" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li class="active"><span>22</span></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="421"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.catalogs.umn.edu/documents/UMNTCGradCDES.pdf','EPRINT'); return false;" href="http://www.catalogs.umn.edu/documents/UMNTCGradCDES.pdf"><span id="translatedtitle"><span class="hlt">Twin</span> Cities Campus Architecture M.Arch.</span></a></p> <p><a target="_blank" href="http://www.osti.gov/eprints/">E-print Network</a></p> <p>Minnesota, University of</p> <p></p> <p>· · · · · · · · - - - <span class="hlt">Twin</span> Cities Campus Architecture M.Arch. School of Architecture College in the context of sustainable environmental systems, urban form, and business economics. The School-professional research degrees, the master of science (M.S.) in architecture, including a sustainable design track</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015FoPh...45.1433G','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015FoPh...45.1433G"><span id="translatedtitle">Secure Communication in the <span class="hlt">Twin</span> Paradox</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Garcia-Escartin, Juan Carlos; Chamorro-Posada, Pedro</p> <p>2015-11-01</p> <p>The amount of information that can be transmitted through a noisy channel is affected by relativistic effects. Under the presence of a fixed noise at the receiver, there appears an asymmetry between "slowly aging" and "fast aging" observers which can be used to have private information transmission. We discuss some models for users inside gravitational wells and in the <span class="hlt">twin</span> paradox scenario.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://files.eric.ed.gov/fulltext/ED437271.pdf','ERIC'); return false;" href="http://files.eric.ed.gov/fulltext/ED437271.pdf"><span id="translatedtitle">Gleanings from Identical <span class="hlt">Twins</span> Studying Science.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Mascazine, John R.</p> <p></p> <p>This paper explains and summarizes the results of a study that investigated the ways in which monozygotic (identical) and dizygotic (fraternal) <span class="hlt">twins</span> learn. Their individual learning style elements were specifically investigated according to the Dunn and Dunn model. This paper discusses the themes, unique needs, and characteristics monozygotic…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/25433579','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/25433579"><span id="translatedtitle">Osteogenesis imperfecta: cesarean deliveries in identical <span class="hlt">twins</span>.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Dinges, E; Ortner, C; Bollag, L; Davies, J; Landau, R</p> <p>2015-02-01</p> <p>Osteogenesis imperfecta is a congenital disorder resulting in multiple fractures and extremely short stature, usually necessitating cesarean delivery. Identical <span class="hlt">twins</span> with severe osteogenesis imperfecta each of whom underwent a cesarean delivery with different anesthetic modalities are presented. A review of the literature and anesthetic options for cesarean delivery and postoperative analgesia for women with osteogenesis imperfecta are discussed. PMID:25433579</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://files.eric.ed.gov/fulltext/ED109580.pdf','ERIC'); return false;" href="http://files.eric.ed.gov/fulltext/ED109580.pdf"><span id="translatedtitle">Creativity in Monozygotic and Dyzygotic <span class="hlt">Twins</span>.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Richmond, Bert O.</p> <p></p> <p>The purpose of this study is to clarify further the relationships among creative, cognitive, and affective production of students. Thirteen pairs of <span class="hlt">twins</span>, eight monozygotic (MZ), five dyzygotic (DZ), were administered the Torrance Tests of Creative Thinking, MMPI, and Revised Beta Examination. The F ratio for testing significance of within-set…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=resting+AND+heart+AND+rate&pg=3&id=EJ333435','ERIC'); return false;" href="http://eric.ed.gov/?q=resting+AND+heart+AND+rate&pg=3&id=EJ333435"><span id="translatedtitle">Heart Rate and Behavior of <span class="hlt">Twins</span>.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Boomsma, Dorret I.; Plomin, Robert</p> <p>1986-01-01</p> <p>Genetic and environmental influences on heart rate were studied in samples of <span class="hlt">twin</span> pairs in middle childhood. Heart rate was measured in resting situation and under two task conditions. Heart rate was related to parental ratings of shyness, emotionality, and selective attention measure. Multivariate analysis suggested that covariance between heart…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://research.chem.psu.edu/mallouk/articles/nl802433u.pdf','EPRINT'); return false;" href="http://research.chem.psu.edu/mallouk/articles/nl802433u.pdf"><span id="translatedtitle">Effect of <span class="hlt">Twinning</span> on the Photoluminescence and</span></a></p> <p><a target="_blank" href="http://www.osti.gov/eprints/">E-print Network</a></p> <p></p> <p></p> <p>, and photoelectrochemistry. Wires with no defects and with {111} <span class="hlt">twin</span> boundaries parallel and perpendicular to the growth crystal.20,21 These defects may potentially be a problem, yet, there is no report on how they affect The relationship between crystal quality and the properties of indium phosphide nanowires grown on silicon (111</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.nature.com/nmeth/journal/v6/n8/pdf/nmeth.1349.pdf','EPRINT'); return false;" href="http://www.nature.com/nmeth/journal/v6/n8/pdf/nmeth.1349.pdf"><span id="translatedtitle">The <span class="hlt">twin</span> spot generator for differential Drosophila</span></a></p> <p><a target="_blank" href="http://www.osti.gov/eprints/">E-print Network</a></p> <p>Cai, Long</p> <p></p> <p>The <span class="hlt">twin</span> spot generator for differential Drosophila lineage analysis Ruth Griffin1, Anne Sustar2 Schubiger2, C-ting Wu3 & Norbert Perrimon3,4 In Drosophila melanogaster, widely used mitotic recombination. In recent years, the most powerful approach in Drosophila mosaic analyses has been the mosaic analysis</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://ntrs.nasa.gov/search.jsp?R=19840010805&hterms=embryo&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D40%26Ntt%3Dembryo','NASA-TRS'); return false;" href="http://ntrs.nasa.gov/search.jsp?R=19840010805&hterms=embryo&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D40%26Ntt%3Dembryo"><span id="translatedtitle"><span class="hlt">Twinning</span> of amphibian embryos by centrifugation</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Black, S. D.</p> <p>1984-01-01</p> <p>In the frog Xenopus laevis, the dorsal structures of the embryonic body axis normally derive from the side of the egg opposite the side of sperm entry. However, if the uncleaved egg is inclined at lg or centrifuged in an inclined position, this topographic relationship is overridden: the egg makes its dorsal axial structures according to its orientation in the gravitational/centrifugal field, irrespective of the position of sperm entry. Certain conditions of centrifugation cause eggs to develop into conjoined <span class="hlt">twins</span> with two sets of axial structures. A detailed analysis of <span class="hlt">twinning</span> provided some insight into experimental axis orientation. First, as with single-axis embryos, both axes in <span class="hlt">twins</span> are oriented according to the direction of centrifugation. One axis forms at the centripetal side of the egg and the other forms at the centrifugal side, even when the side of sperm entry is normal to the centrifugal force vector. Second, if eggs are centrifuged to give <span class="hlt">twins</span>, but are inclined at lg to prevent post-centrifugation endoplasmic redistributions, only single-axis embryos develop. Thus, a second redistribution is required for high-frequency secondary axis formation. This can be accomplished by lg (as in the single centrifugations) or by a second centrifugation directed along the egg's animal-vegetal axis.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/3754958','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/3754958"><span id="translatedtitle">Simultaneous sudden infant death syndrome in <span class="hlt">twins</span>.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Smialek, J E</p> <p>1986-06-01</p> <p>Nine cases of <span class="hlt">twin</span> infants dying suddenly and simultaneously are described, two of which the author examined personally. A review of this phenomenon described in other literature is also presented. It is hoped that increased awareness of this phenomenon will decrease the profound suspicions of both lay and professional persons that the deaths were due to criminal instrumentality. PMID:3754958</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ars.usda.gov/research/publications/Publications.htm?seq_no_115=204665','TEKTRAN'); return false;" href="http://www.ars.usda.gov/research/publications/Publications.htm?seq_no_115=204665"><span id="translatedtitle"><span class="hlt">Twin</span> Row Conservation Tillage Corn Production</span></a></p> <p><a target="_blank" href="http://www.ars.usda.gov/services/TekTran.htm">Technology Transfer Automated Retrieval System (TEKTRAN)</a></p> <p></p> <p></p> <p>Corn (Zea mays L.) seeded in narrow row patterns can increase yields and accelerate canopy closure; however, costly equipment modifications make narrow rows impractical. <span class="hlt">Twin</span> row patterns are a compromise to enhance the benefit of narrow rows with fewer equipment modifications. We compared yield, ...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=special+AND+relativity&id=EJ963861','ERIC'); return false;" href="http://eric.ed.gov/?q=special+AND+relativity&id=EJ963861"><span id="translatedtitle"><span class="hlt">Twin</span> Paradox in de Sitter Spacetime</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Boblest, Sebastian; Muller, Thomas; Wunner, Gunter</p> <p>2011-01-01</p> <p>The "<span class="hlt">twin</span> paradox" of special relativity offers the possibility of making interstellar flights within a lifetime. For very long journeys with velocities close to the speed of light, however, we have to take into account the expansion of the universe. Inspired by the work of Rindler on hyperbolic motion in curved spacetime, we study the worldline…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=serbian&pg=6&id=EJ557028','ERIC'); return false;" href="http://eric.ed.gov/?q=serbian&pg=6&id=EJ557028"><span id="translatedtitle">Babbling of <span class="hlt">Twins</span> in a Bilingual Environment.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Zlatic, Larisa; Macneilage, Peter; Matyear, Christine L.; Davis, Barbara L.</p> <p>1997-01-01</p> <p>Examines the phonetic characteristics of babbling by a pair of fraternal <span class="hlt">twins</span> raised in a bilingual environment (English/Serbian). The study focused on the basic articulatory form of babbling, the impact of twinship on babbling patterns, and whether effects specific to one or another of the ambient languages could be observed. (30 references)…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://math.uark.edu/Relativity.pdf','EPRINT'); return false;" href="http://math.uark.edu/Relativity.pdf"><span id="translatedtitle">Einstein,s <span class="hlt">Twin</span> Paradox Special Relativity</span></a></p> <p><a target="_blank" href="http://www.osti.gov/eprints/">E-print Network</a></p> <p>Capogna, Luca</p> <p></p> <p>Einstein,s <span class="hlt">Twin</span> Paradox Special Relativity Einstein's special theory of relativity is based as Maxwell's equations. These equations predict that electromagnetic waves including light travel at the same Special Theory of Relativity, which includes the phenomenon of time dilation. All of the surprising</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/1997PhyEd..32..308L','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/1997PhyEd..32..308L"><span id="translatedtitle">NEW APPROACHES: The <span class="hlt">twins</span> paradox explained</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Linton, J. O.</p> <p>1997-09-01</p> <p>The well-known paradox of the space-travelling <span class="hlt">twins</span> is easily stated, but it is not at all easy to explain, especially to a perspicacious audience. This essay attempts to set out an explanation (largely inspired by Paul Davies' book About Time [1]) which should be within the grasp of an intelligent sixth-former.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=childhood+AND+effects+AND+brain+AND+development&pg=2&id=EJ950022','ERIC'); return false;" href="http://eric.ed.gov/?q=childhood+AND+effects+AND+brain+AND+development&pg=2&id=EJ950022"><span id="translatedtitle">A Pediatric <span class="hlt">Twin</span> Study of Brain Morphometry</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Wallace, Gregory L.; Schmitt, J. Eric; Lenroot, Rhoshel; Viding, Essi; Ordaz, Sarah; Rosenthal, Michael A.; Molloy, Elizabeth A.; Clasen, Liv S.; Kendler, Kenneth S.; Neale, Michael C.; Giedd, Jay N.</p> <p>2006-01-01</p> <p>Background: Longitudinal pediatric neuroimaging studies have demonstrated increasing volumes of white matter and regionally-specific inverted U shaped developmental trajectories of gray matter volumes during childhood and adolescence. Studies of monozygotic and dyzygotic <span class="hlt">twins</span> during this developmental period allow exploration of genetic and…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3975649','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3975649"><span id="translatedtitle">Late language emergence in 24 month <span class="hlt">twins</span>: Heritable and increased risk for LLE in <span class="hlt">twins</span></span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Rice, Mabel L.; Zubrick, Stephen R.; Taylor, Catherine L.; Gayán, Javier; Bontempo, Daniel E.</p> <p>2013-01-01</p> <p>Purpose This study investigated the etiology of Late Language Emergence (LLE) in 24-month-old <span class="hlt">twins</span> considering possible <span class="hlt">twinning</span>, zygosity, gender, and heritability effects for vocabulary and grammar phenotypes. Method A population-based sample of 473 <span class="hlt">twin</span> pairs participated. Multilevel modelling estimated means and variances of vocabulary and grammar phenotypes, controlling for familiality. Heritability was estimated with DeFries-Fulker regression, and variance components models, to determine effects of heritability, shared-environment, and non-shared environment. Results <span class="hlt">Twins</span> had lower average language scores than norms for singleborn children, with lower average performance for MZ than DZ <span class="hlt">twins</span>, and lower for boys than girls, although gender and zygosity did not interact. Gender did not predict LLE. Significant heritability was detected for vocabulary (.26) and grammar phenotypes (.52/.43 for males/females) in the full sample, and in the sample selected for LLE (.42 and .44). LLE and the appearance of Word Combinations were also significantly heritable (.22-.23). Conclusion The findings revealed an increased likelihood of LLE in <span class="hlt">twin</span> toddlers compared to singleborn children that is modulated by zygosity and gender differences. Heritability estimates are consistent with previous research for vocabulary and add further suggestion of heritable differences in early grammar acquisition. PMID:24167238</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2013APS..MARM46006L','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2013APS..MARM46006L"><span id="translatedtitle">Reflectance spectrometry of placental vessels in cases of <span class="hlt">twin-twin</span> transfusion syndrome: experiments and modeling</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Lines, Collin; Kim, Oleg; McMurdy, John; Luks, Francois; Alber, Mark; Crawford, Greg</p> <p>2013-03-01</p> <p>A stochastic photon transport model in multilayer skin tissue combined with reflectance spectroscopy measurements is used to study placental vessels in cases of <span class="hlt">twin-twin</span> transfusion syndrome (TTTS). TTTS occurs in about 12% of monozygotic (identical) <span class="hlt">twin</span> pregnancies wherein flow within placental vessels linking the <span class="hlt">twins</span> together becomes unbalanced, leading to dual mortality. Endoscopic laser ablation can halt the syndrome by occluding the anastomoses connecting the two fetuses. The objective of this study is to develop a technique to determine hemoglobin (Hb) content through spectral analysis of diffuse reflectance spectra of placental vessels to aid in identification of the anastomoses. Previous work by researchers at Brown University has shown that the reflectance spectra of the donor <span class="hlt">twin</span> and recipient <span class="hlt">twin</span> are considerably different in the wavelengths for Hb absorbance. This presentation will give preliminary results for a Monte Carlo model adapted to fit the physiology of the placenta that can be used to quantitative determine the Hb levels. The reflectance spectra of the vessels are simulated for different values of Hb as well oxygenation and water concentration with the vessel and placental mass. The preliminary results will be shown to be in good approximation with the prior experimental data. The combination of modeling with spectroscopic measurement will provide a new tool for detailed prenatal study.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/23590349','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/23590349"><span id="translatedtitle">Brother-<span class="hlt">sister</span> incest: data from anonymous computer-assisted self interviews.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Stroebel, Sandra S; O'Keefe, Stephen L; Beard, Keith W; Kuo, Shih-Ya; Swindell, Samuel; Stroupe, Walter</p> <p>2013-01-01</p> <p>Retrospective data were entered anonymously by 1,521 adult women using computer-assisted self interview. Forty were classified as victims of brother-<span class="hlt">sister</span> incest, 19 were classified as victims of father-daughter incest, and 232 were classified as victims of sexual abuse by an adult other than their father before reaching 18 years of age. The other 1,230 served as controls. The victims of brother-<span class="hlt">sister</span> incest had significantly more problematic outcomes than controls on many measures (e.g., more likely than the controls to endorse feeling like damaged goods, thinking that they had suffered psychological injury, and having undergone psychological treatment for childhood sexual abuse). However, victims of brother-<span class="hlt">sister</span> incest also had significantly less problematic outcomes than victims of father-daughter incest on some measures (e.g., significantly less likely than the father-daughter incest victims to endorse feeling like damaged goods, thinking that they had suffered psychological injury, and having undergone psychological treatment for childhood sexual abuse). PMID:23590349</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4282572','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4282572"><span id="translatedtitle">Functional genomics identifies a requirement of pre-mRNA splicing factors for <span class="hlt">sister</span> chromatid cohesion</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Sundaramoorthy, Sriramkumar; Vázquez-Novelle, María Dolores; Lekomtsev, Sergey; Howell, Michael; Petronczki, Mark</p> <p>2014-01-01</p> <p><span class="hlt">Sister</span> chromatid cohesion mediated by the cohesin complex is essential for chromosome segregation during cell division. Using functional genomic screening, we identify a set of 26 pre-mRNA splicing factors that are required for <span class="hlt">sister</span> chromatid cohesion in human cells. Loss of spliceosome subunits increases the dissociation rate of cohesin from chromatin and abrogates cohesion after DNA replication, ultimately causing mitotic catastrophe. Depletion of splicing factors causes defective processing of the pre-mRNA encoding sororin, a factor required for the stable association of cohesin with chromatin, and an associated reduction of sororin protein level. Expression of an intronless version of sororin and depletion of the cohesin release protein WAPL suppress the cohesion defect in cells lacking splicing factors. We propose that spliceosome components contribute to <span class="hlt">sister</span> chromatid cohesion and mitotic chromosome segregation through splicing of sororin pre-mRNA. Our results highlight the loss of cohesion as an early cellular consequence of compromised splicing. This may have clinical implications because SF3B1, a splicing factor that we identify to be essential for cohesion, is recurrently mutated in chronic lymphocytic leukaemia. PMID:25257310</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li class="active"><span>22</span></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_22 --> <div id="page_23" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li class="active"><span>23</span></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li><a href="#" onclick='return showDiv("page_25");'>25</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="441"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=37431','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=37431"><span id="translatedtitle">Evidence that replication fork components catalyze establishment of cohesion between <span class="hlt">sister</span> chromatids</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Carson, Dena R.; Christman, Michael F.</p> <p>2001-01-01</p> <p>Accurate chromosome segregation requires that replicated <span class="hlt">sister</span> chromatids are held together until anaphase, when their “cohesion” is dissolved, and they are pulled to opposite spindle poles by microtubules. Establishment of new cohesion between <span class="hlt">sister</span> chromatids in the next cell cycle is coincident with replication fork passage. Emerging evidence suggests that this temporal coupling is not just a coincident timing of independent events, but rather that the establishment of cohesion is likely to involve the active participation of replication-related activities. These include PCNA, a processivity clamp for some DNA polymerases, Trf4/Pol ? (formerly Trf4/Pol?), a novel and essential DNA polymerase, and a modified Replication Factor C clamp–loader complex. Here we describe recent advances in how cohesion establishment is linked to replication, highlight important unanswered questions in this new field, and describe a “polymerase switch” model for how cohesion establishment is coupled to replication fork progression. Building the bridges between newly synthesized <span class="hlt">sister</span> chromatids appears to be a fundamental but previously unrecognized function of the eukaryotic replication machinery. PMID:11459963</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/22644811','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/22644811"><span id="translatedtitle">Arrangement of nuclear structures is not transmitted through mitosis but is identical in <span class="hlt">sister</span> cells.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Orlova, Darya Yu; Stixová, Lenka; Kozubek, Stanislav; Gierman, Hinco J; Šustá?ková, Gabriela; Chernyshev, Andrei V; Medvedev, Ruslan N; Legartová, So?a; Versteeg, Rogier; Matula, Pavel; Stoklasa, Roman; Bártová, Eva</p> <p>2012-11-01</p> <p>Although it is well known that chromosomes are non-randomly organized during interphase, it is not completely clear whether higher-order chromatin structure is transmitted from mother to daughter cells. Therefore, we addressed the question of how chromatin is rearranged during interphase and whether heterochromatin pattern is transmitted after mitosis. We additionally tested the similarity of chromatin arrangement in <span class="hlt">sister</span> interphase nuclei. We noticed a very active cell rotation during interphase, especially when histone hyperacetylation was induced or transcription was inhibited. This natural phenomenon can influence the analysis of nuclear arrangement. Using photoconversion of Dendra2-tagged core histone H4 we showed that the distribution of chromatin in daughter interphase nuclei differed from that in mother cells. Similarly, the nuclear distribution of heterochromatin protein 1? (HP1?) was not completely identical in mother and daughter cells. However, identity between mother and daughter cells was in many cases evidenced by nucleolar composition. Moreover, morphology of nucleoli, HP1? protein, Cajal bodies, chromosome territories, and gene transcripts were identical in <span class="hlt">sister</span> cell nuclei. We conclude that the arrangement of interphase chromatin is not transmitted through mitosis, but the nuclear pattern is identical in naturally synchronized <span class="hlt">sister</span> cells. It is also necessary to take into account the possibility that cell rotation and the degree of chromatin condensation during functionally specific cell cycle phases might influence our view of nuclear architecture. PMID:22644811</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4629883','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4629883"><span id="translatedtitle">Pyrosequencing of Plaque Microflora In <span class="hlt">Twin</span> Children with Discordant Caries Phenotypes</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Zhang, Meng; Chen, Yongxing; Xie, Lingzhi; Li, Yuhong; Jiang, Han; Du, Minquan</p> <p>2015-01-01</p> <p>Despite recent successes in the control of dental caries, the mechanism of caries development remains unclear. To investigate the causes of dental decay, especially in early childhood caries, the supragingival microflora composition of 20 <span class="hlt">twins</span> with discordant caries phenotypes were analyzed using high-throughput pyrosequencing. In addition, the parents completed a lifestyle questionnaire. A total of 228,789 sequencing reads revealed 10 phyla, 84 genera, and 155 species of microflora, the relative abundances of these strains varied dramatically among the children, Comparative analysis between groups revealed that Veillonella, Corynebacterium and Actinomyces were presumed to be caries-related genera, Fusobacterium, Kingella and Leptotrichia were presumed to be <span class="hlt">healthy</span>-related genus, yet this six genera were not statistically significant (P>0.05). Moreover, a cluster analysis revealed that the microbial composition of samples in the same group was often dissimilar but that the microbial composition observed in <span class="hlt">twins</span> was usually similar. Although the genetic and environmental factors that strongly influence the microbial composition of dental caries remains unknown, we speculate that genetic factors primarily influence the individual's susceptibility to dental caries and that environmental factors primarily regulate the microbial composition of the dental plaque and the progression to caries. By using improved <span class="hlt">twins</span> models and increased sample sizes, our study can be extended to analyze the specific genetic and environmental factors that affect the development of caries. PMID:26524687</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4625291','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4625291"><span id="translatedtitle">A Rare Case of Bilateral Broad Ligament Haematoma in <span class="hlt">Twin</span> Pregnancy</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Bankada, Vijayalakshmi; Ningappa, Amulya Marikatte; Jirankal, Shankar</p> <p>2015-01-01</p> <p>We report a rare case of bilateral broad ligament haematoma in <span class="hlt">twin</span> pregnancy presented as gravida 3 para 2 living 2 (G3P2A0L2), with undelivered second <span class="hlt">twin</span> with transverse lie with cord and hand prolapse with obstructed labour referred to our hospital from primary health centre after spontaneous vaginal delivery of first live <span class="hlt">healthy</span> <span class="hlt">twin</span> baby four hours later. On examination patient was stable, her investigations were within normal limits and patient was taken up for emergency lower segment caesarian section. Intraoperatively features of obstructed labour were present; a dead term baby was extracted with dichorionic diamniotic placenta. Bilateral broad ligament haematomas approximately of 8x8 cm were noted which were increasing in size after extraction of baby. On both sides haematomas were evacuated and drained along with bilateral uterine artery ligation. Three pints of blood were transfused intra and postoperatively. Her postoperative period was uneventful and the patient was discharged on postoperative day 14. PMID:26557572</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://dspace.mit.edu/handle/1721.1/98099','EPRINT'); return false;" href="http://dspace.mit.edu/handle/1721.1/98099"><span id="translatedtitle">Variations in dysfunction of <span class="hlt">sister</span> chromatid cohesion in esco2 mutant zebrafish reflect the phenotypic diversity of Roberts syndrome</span></a></p> <p><a target="_blank" href="http://www.osti.gov/eprints/">E-print Network</a></p> <p>Percival, Stefanie M.</p> <p></p> <p>Mutations in ESCO2, one of two establishment of cohesion factors necessary for proper <span class="hlt">sister</span> chromatid cohesion (SCC), cause a spectrum of developmental defects in the autosomal-recessive disorder Roberts syndrome (RBS), ...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://dspace.mit.edu/handle/1721.1/74512','EPRINT'); return false;" href="http://dspace.mit.edu/handle/1721.1/74512"><span id="translatedtitle">LAB-1 Targets PP1 and Restricts Aurora B Kinase upon Entrance into Meiosis to Promote <span class="hlt">Sister</span> Chromatid Cohesion</span></a></p> <p><a target="_blank" href="http://www.osti.gov/eprints/">E-print Network</a></p> <p>Cheeseman, Iain McPherson</p> <p></p> <p>Successful execution of the meiotic program depends on the timely establishment and removal of <span class="hlt">sister</span> chromatid cohesion. LAB-1 has been proposed to act in the latter by preventing the premature removal of the meiosis-specific ...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://cfpub.epa.gov/si/si_public_record_report.cfm?dirEntryId=39928&keyword=sce&actType=&TIMSType=+&TIMSSubTypeID=&DEID=&epaNumber=&ntisID=&archiveStatus=Both&ombCat=Any&dateBeginCreated=&dateEndCreated=&dateBeginPublishedPresented=&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&dateBeginCompleted=&dateEndCompleted=&personID=&role=Any&journalID=&publisherID=&sortBy=revisionDate&count=50&CFID=55247118&CFTOKEN=47609708','EPA-EIMS'); return false;" href="http://cfpub.epa.gov/si/si_public_record_report.cfm?dirEntryId=39928&keyword=sce&actType=&TIMSType=+&TIMSSubTypeID=&DEID=&epaNumber=&ntisID=&archiveStatus=Both&ombCat=Any&dateBeginCreated=&dateEndCreated=&dateBeginPublishedPresented=&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&dateBeginCompleted=&dateEndCompleted=&personID=&role=Any&journalID=&publisherID=&sortBy=revisionDate&count=50&CFID=55247118&CFTOKEN=47609708"><span id="translatedtitle">INDUCTION, ACCUMULATION, AND PERSISTENCE OF <span class="hlt">SISTER</span> CHROMATID EXCHANGES IN WOMEN WITH BREAST CANCER RECEIVING CYCLOPHOSPHAMIDE, ANDRIAMYCIN, AND 5-FLUOROACIL CHEMOTHERAPY</span></a></p> <p><a target="_blank" href="http://oaspub.epa.gov/eims/query.page">EPA Science Inventory</a></p> <p></p> <p></p> <p>The induction, stimulation, and persistence of <span class="hlt">sister</span> chromatid exchanges (SCE's) and high SCE frequency cells (HFC's) was measured in peripheral lymphocytes of women with breast cancer before chemotherapy and on multiple occasions during and after therapy. Chemotherapy consisted...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2005PhRvB..71v4102O','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2005PhRvB..71v4102O"><span id="translatedtitle">Energy landscape of deformation <span class="hlt">twinning</span> in bcc and fcc metals</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Ogata, Shigenobu; Li, Ju; Yip, Sidney</p> <p>2005-06-01</p> <p>Energy landscapes of (21¯1¯)?111? deformation <span class="hlt">twinning</span> in bcc Mo and (111)?112¯? deformation <span class="hlt">twinning</span> in fcc Al and Cu are determined using density functional theory for sliding of layers numbering up to 7. In bcc Mo, the minimum thickness of a metastable <span class="hlt">twin</span> is two layers, while <span class="hlt">twin</span> embryos of three and four layers are unstable. Starting from five layers, the Mo <span class="hlt">twin</span> can grow in a layer-by-layer fashion. The <span class="hlt">twin</span> boundary formation and migration energies are found to be 607 and 40mJ/m , respectively, implying that partial dislocations on <span class="hlt">twin</span> boundaries will have wide cores and high mobilities. The stress to homogeneously nucleate a partial loop on the boundary of a thick <span class="hlt">twin</span> is determined to be only 1.4GPa , indicating that once a deformation <span class="hlt">twin</span> in Mo reaches a critical thickness, which we estimate to be six layers, it can grow rather easily. Based on simple defect mechanics considerations, we estimate the condition for runaway defect growth requires <span class="hlt">twin</span> embryo thickness to be tens of layers. Comparing the <span class="hlt">twinning</span> energy landscape for Mo with those of Al and Cu, we find the former to have a longer ranged interlayer mechanical coupling, which is due to angular bonding and weaker electron screening in the intervening layers. Between Al and Cu, interactions in the former are relatively longer ranged.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://ntrs.nasa.gov/search.jsp?R=PIA06322&hterms=Herschel+William&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D40%26Ntt%3D%2528Herschel%2BWilliam%2529','NASA-TRS'); return false;" href="http://ntrs.nasa.gov/search.jsp?R=PIA06322&hterms=Herschel+William&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D40%26Ntt%3D%2528Herschel%2BWilliam%2529"><span id="translatedtitle">Morphology of Our Galaxy's '<span class="hlt">Twin</span>'</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p></p> <p>2004-01-01</p> <p><p/> NASA's Spitzer Space Telescope has captured these infrared images of a nearby spiral galaxy that resembles our own Milky Way. The targeted galaxy, known as NGC 7331 and sometimes referred to as our galaxy's <span class="hlt">twin</span>, is found in the constellation Pegasus at a distance of 50 million light-years. This inclined galaxy was discovered in 1784 by William Herschel, who also discovered infrared light. <p/> The evolution of this galaxy is a story that depends significantly on the amount and distribution of gas and dust, the locations and rates of star formation, and on how the energy from star formation is recycled by the local environment. The new Spitzer images are allowing astronomers to 'read' this story by dissecting the galaxy into its separate components. <p/> The image, measuring 12.6 by 8.2 arcminutes, was obtained by Spitzer's infrared array camera. It is a four-color composite of invisible light, showing emissions from wavelengths of 3.6 microns (blue), 4.5 microns (green), 5.8 microns (yellow) and 8.0 microns (red). These wavelengths are roughly 10 times longer than those seen by the human eye. <p/> The infrared light seen in this image originates from two very different sources. At shorter wavelengths (3.6 to 4.5 microns), the light comes mainly from stars, particularly ones that are older and cooler than our Sun. This starlight fades at longer wavelengths (5.8 to 8.0 microns), where instead we see the glow from clouds of interstellar dust. This dust consists mainly of a variety of carbon-based organic molecules known collectively as polycyclic aromatic hydrocarbons. Wherever these compounds are found, there will also be dust granules and gas, which provide a reservoir of raw materials for future star formation. <p/> One feature that stands out in the Spitzer image is the ring of actively forming stars that surrounds the galaxy center (yellow). This ring, with a radius of nearly 20,000 light-years, is invisible at shorter wavelengths, yet has been detected at sub-millimeter and radio wavelengths. It is made up in large part of polycyclic aromatic hydrocarbons. Spitzer measurements suggest that the ring contains enough gas to produce four billion stars like the Sun. <p/> Three other galaxies are seen below NGC 7331, all about 10 times farther away. From left to right are NGC 7336, NGC 7335 and NGC 7337. The blue dots scattered throughout the images are foreground stars in the Milky Way; the red ones are galaxies that are even more distant. <p/> The Spitzer observations of NGC 7331 are part of a large 500-hour science project, known as the Spitzer Infrared Nearby Galaxy Survey, which will comprehensively study 75 nearby galaxies with infrared imaging and spectroscopy. <p/></p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/25851727','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/25851727"><span id="translatedtitle">Why Accurate Knowledge of Zygosity is Important to <span class="hlt">Twins</span>.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Cutler, Tessa L; Murphy, Kate; Hopper, John L; Keogh, Louise A; Dai, Yun; Craig, Jeffrey M</p> <p>2015-06-01</p> <p>All same-sex dizygotic (DZ) <span class="hlt">twins</span> and approximately one-third of monozygotic (MZ) <span class="hlt">twin</span> pairs have separate placentas, making it impossible to use the number of placentas to determine zygosity. Zygosity determination is further complicated because incorrect assumptions are often made, such as that only DZ pairs have two placentas and that all MZ pairs are phenotypically identical. These assumptions, by <span class="hlt">twins</span>, their families and health professionals, along with the lack of universal zygosity testing for same-sex <span class="hlt">twins</span>, has led to confusion within the <span class="hlt">twin</span> community, yet little research has been conducted with <span class="hlt">twins</span> about their understanding and assumptions about zygosity. We aimed to explore and quantify understanding and assumptions about zygosity using <span class="hlt">twins</span> attending an Australian <span class="hlt">twin</span> festival. We recruited 91 <span class="hlt">twin</span> pairs younger than 18 years of age and their parents, and 30 adult <span class="hlt">twin</span> pairs who were all uncertain of their zygosity, to complete one pen and paper questionnaire and one online questionnaire about their assumed zygosity, reasons for their assumptions and the importance of accurate zygosity knowledge. Responses were compared with their true zygosity measured using a genetic test. We found a substantial proportion of parents and <span class="hlt">twins</span> had been misinformed by their own parents or medical professionals, and that knowledge of their true zygosity status provided peace of mind and positive emotional responses. For these reasons we propose universal zygosity testing of same-sex <span class="hlt">twins</span> as early in life as possible and an increase in education of medical professionals, <span class="hlt">twins</span> and families of <span class="hlt">twins</span> about zygosity issues. PMID:25851727</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3431552','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3431552"><span id="translatedtitle">Tools for <span class="hlt">Healthy</span> Tribes</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Fleischhacker, Sheila; Byrd, Randi R.; Ramachandran, Gowri; Vu, Maihan; Ries, Amy; Bell, Ronny A.; Evenson, Kelly R.</p> <p>2012-01-01</p> <p>There is growing recognition that policymakers can promote access to <span class="hlt">healthy</span>, affordable foods within neighborhoods, schools, childcare centers, and workplaces. Despite the disproportionate risk of obesity and type 2 diabetes among American Indian children and adults, comparatively little attention has been focused on the opportunities tribal policymakers have to implement policies or resolutions to promote access to <span class="hlt">healthy</span>, affordable foods. This paper presents an approach for integrating formative research into an action-oriented strategy of developing and disseminating tribally led environmental and policy strategies to promote access to and consumption of <span class="hlt">healthy</span>, affordable foods. This paper explains how the American Indian <span class="hlt">Healthy</span> Eating Project evolved through five phases and discusses each phase’s essential steps involved, outcomes derived, and lessons learned. Using community-based participatory research and informed by the Social Cognitve Theory and ecologic frameworks, the American Indian <span class="hlt">Healthy</span> Eating Project was started in fall 2008 and has evolved through five phases: (1) starting the conversation; (2) conducting multidisciplinary formative research; (3) strengthening partnerships and tailoring policy options; (4) disseminating community-generated ideas; and (5) accelerating action while fostering sustainability. Collectively, these phases helped develop and disseminate Tools for <span class="hlt">Healthy</span> Tribes—a toolkit used to raise awareness among participating tribal policymakers of their opportunities to improve access to <span class="hlt">healthy</span>, affordable foods. Formal and informal strategies can engage tribal leaders in the development of culturally appropriate and tribe-specific sustainable strategies to improve such access, as well as empower tribal leaders to leverage their authority toward raising a healthier generation of American Indian children. PMID:22898161</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1470669','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1470669"><span id="translatedtitle">Chl1p, a DNA helicase-like protein in budding yeast, functions in <span class="hlt">sister</span>-chromatid cohesion.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Skibbens, Robert V</p> <p>2004-01-01</p> <p>From the time of DNA replication until anaphase onset, <span class="hlt">sister</span> chromatids remain tightly paired along their length. Ctf7p/Eco1p is essential to establish <span class="hlt">sister</span>-chromatid pairing during S-phase and associates with DNA replication components. DNA helicases precede the DNA replication fork and thus will first encounter chromatin sites destined for cohesion. In this study, I provide the first evidence that a DNA helicase is required for proper <span class="hlt">sister</span>-chromatid cohesion. Characterizations of chl1 mutant cells reveal that CHL1 interacts genetically with both CTF7/ECO1 and CTF18/CHL12, two genes that function in <span class="hlt">sister</span>-chromatid cohesion. Consistent with genetic interactions, Chl1p physically associates with Ctf7p/Eco1p both in vivo and in vitro. Finally, a functional assay reveals that Chl1p is critical for <span class="hlt">sister</span>-chromatid cohesion. Within the budding yeast genome, Chl1p exhibits the highest degree of sequence similarity to human CHL1 isoforms and BACH1. Previous studies revealed that human CHLR1 exhibits DNA helicase-like activities and that BACH1 is a helicase-like protein that associates with the tumor suppressor BRCA1 to maintain genome integrity. Our findings document a novel role for Chl1p in <span class="hlt">sister</span>-chromatid cohesion and provide new insights into the possible mechanisms through which DNA helicases may contribute to cancer progression when mutated. PMID:15020404</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015JOM....67h1748C','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015JOM....67h1748C"><span id="translatedtitle">In Situ Scanning Electron Microscopy Observations of Contraction <span class="hlt">Twinning</span> and Double <span class="hlt">Twinning</span> in Extruded Mg-1Mn (wt.%)</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Chakkedath, A.; Boehlert, C. J.</p> <p>2015-08-01</p> <p>The tensile deformation mechanisms of an extruded Mg-1Mn (wt.%) alloy at 323 K (50°C) was investigated by a combination of in situ tensile testing and electron backscatter diffraction analysis. The strong basal texture of the material resulted in placing the c-axis of most of the grains under compression during tensile loading parallel to the extrusion axis. Basal, prismatic, and pyramidal < c+ a> slip activity was observed along with extension <span class="hlt">twinning</span>. However, contraction <span class="hlt">twinning</span> dominated the deformation. Although contraction <span class="hlt">twinning</span> and pyramidal < c+ a> slip both allow for c-component deformation, contraction <span class="hlt">twinning</span> was preferred over pyramidal < c+ a> slip, and this was expected to be due to the lower critical resolved shear stress (CRSS) value for the former mechanism at ambient temperatures. The contraction <span class="hlt">twins</span> evolved into double <span class="hlt">twins</span> with an increase in strain. The propensity of double <span class="hlt">twins</span> to form shear bands due to shear localization within the double <span class="hlt">twinned</span> region, which eventually resulted in cracks, led to the failure of the material. The shear localization in the double <span class="hlt">twins</span> was expected to be due to the enhanced activity of basal slip in the <span class="hlt">twinned</span> volume. The observations from the present study suggest that contraction <span class="hlt">twinning</span> may play a critical role in the limited cold formability of magnesium and its alloys.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/18251684','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/18251684"><span id="translatedtitle">Personality and birth order in monozygotic <span class="hlt">twins</span> adopted apart: a test of Sulloway's theory; Research Reviews: <span class="hlt">twin</span> births and cancer risk in mothers, male sexual dysfunction, <span class="hlt">twin</span> study of ultimatum game behavior; Human Interest: 'The Land of <span class="hlt">Twins</span>', <span class="hlt">twin</span>-like reunion-I, <span class="hlt">twin</span>-like reunion-II.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Segal, Nancy L</p> <p>2008-02-01</p> <p>A brief overview of Sulloway's (1996) theory of birth order and personality is presented. A reared apart <span class="hlt">twin</span> approach for testing his personality findings regarding openness to experience and conscientiousness in first borns and later borns is described. This is followed by summaries of three recent <span class="hlt">twin</span> studies. The topics include cancer risk in mother of <span class="hlt">twins</span>, sexual dysfunction in males and responder behavior during ultimatum games. This article concludes with a discussion of <span class="hlt">twinning</span> rates and rituals among the Yoruba of western Nigeria, and descriptions of two unusual reunions between siblings and <span class="hlt">twins</span>. PMID:18251684</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://files.eric.ed.gov/fulltext/ED527015.pdf','ERIC'); return false;" href="http://files.eric.ed.gov/fulltext/ED527015.pdf"><span id="translatedtitle"><span class="hlt">Healthy</span> Schools Network, 2011 Yearbook</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Healthy Schools Network, Inc., 2011</p> <p>2011-01-01</p> <p>This paper presents the 2011 Yearbook of the <span class="hlt">Healthy</span> Schools Network. This yearbook contains: (1) Tough Time To Be a Child: Parents and Taxpayers Should Be Enraged; (2) National Coalition For Healthier Schools: <span class="hlt">Healthy</span> Schools 2015--Sustaining Momentum In Tough Times; (3) <span class="hlt">Healthy</span> Schools Heroes Award Program; (4) National <span class="hlt">Healthy</span> Schools Day…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/17254404','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/17254404"><span id="translatedtitle">The Qingdao <span class="hlt">Twin</span> Registry: a focus on chronic disease research.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Pang, Zengchang; Ning, Feng; Unger, Jennifer; Johnson, C Anderson; Wang, Shaojie; Guo, Qian; Cao, Weihua; Lee, Liming</p> <p>2006-12-01</p> <p>With the changing patterns of morbidity and mortality in China, noncommunicable chronic diseases have become the major threats to the health of the Chinese population. The causes of chronic diseases include genetic factors and behavioral risk factors such as the use of tobacco, alcohol, and other drugs, unhealthy dietary behaviors, and lack of physical activity. <span class="hlt">Twin</span> studies offer a unique opportunity to disentangle the genetic and environmental risk and protective factors for chronic disease. The Qingdao <span class="hlt">Twin</span> Registry (QTR) was initiated in 1998 as part of the National Chinese <span class="hlt">Twin</span> Registry. Over 11,000 pairs of <span class="hlt">twins</span> and multiples of all ages have been recruited into the registry. Several studies of physical and mental health are underway. Many of the adult <span class="hlt">twins</span> have completed health and behavioral risk factor surveys, and the adolescent <span class="hlt">twins</span> are participating in a study of gene-environment interactions in tobacco and alcohol use. Studies of the heritability of personality factors have been conducted. In 2002, Qingdao established the Qingdao <span class="hlt">Twin</span> Health Promotion Association, a nonprofit organization that supports health services for <span class="hlt">twins</span> and their parents, organizes special events and health-related activities for <span class="hlt">twins</span>, and raises funds to conduct <span class="hlt">twin</span> health examinations. The QTR will be a useful resource for future studies of population genetics in human health and disease. PMID:17254404</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/26137974','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/26137974"><span id="translatedtitle">Face processing among <span class="hlt">twins</span> with and without autism: social correlates and <span class="hlt">twin</span> concordance.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Neuhaus, Emily; Kresse, Anna; Faja, Susan; Bernier, Raphael A; Webb, Sara Jane</p> <p>2016-01-01</p> <p>Autism spectrum disorder (ASD) has a strong heritable basis, as evidenced by <span class="hlt">twin</span> concordance rates. Within ASD, symptom domains may arise via independent genetic contributions, with varying heritabilities and genetic mechanisms. In this article, we explore social functioning in the form of (i) electrophysiological and behavioral measures of face processing (P1 and N170) and (ii) social behavior among child and adolescent <span class="hlt">twins</span> with (N?=?52) and without ASD (N?=?66). <span class="hlt">Twins</span> without ASD had better holistic face processing and face memory, faster P1 responses and greater sensitivity to the effects of facial inversion on P1. In contrast, N170 responses to faces were similar across diagnosis, with more negative amplitudes for faces vs non-face images. Across the sample, stronger social skills and fewer social difficulties were associated with faster P1 and N170 responses to upright faces, and better face memory. <span class="hlt">Twins</span> were highly correlated within pairs across most measures, but correlations were significantly stronger for monozygotic vs dizygotic pairs on N170 latency and social problems. We suggest common developmental influences across <span class="hlt">twins</span> for face processing and social behavior, but highlight (i) neural speed of face processing and (ii) social difficulties as important avenues in the search for genetic underpinnings in ASD. PMID:26137974</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4660864','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4660864"><span id="translatedtitle">Infantile systemic hyalinosis in identical <span class="hlt">twins</span></span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Koonuru, Mahesh Kumar; Venugopal, Satya Prasad</p> <p>2015-01-01</p> <p>Summary Infantile systemic hyalinosis (ISH) is a rare disorder belonging to the heterogeneous group of genetic fibromatoses. It is a rare, progressive, fatal autosomal recessive condition characterized by widespread deposition of hyaline material in many tissues caused by mutations in the anthrax toxin receptor 2 gene - ANTXR2. It presents hyperpigmented skin over bony prominences. Characteristic purplish patches develop over the medial and lateral malleoli of the ankles, the metacarpophalangeal joints, spine and elbows, with progressive joint contractures, osteopenia, skin abnormalities and chronic severe pain. The present case reports the occurrence of infantile systemic hyalinosis in <span class="hlt">twin</span> brothers five months of age who had come for early intervention for joint contractures representing characteristic brownish patches over bony prominences. ISH cases reported until this date have been less than 20 and the present case is unique in nature since this is the first time ISH is reported in <span class="hlt">twins</span> globally and the symptoms have been identified at an early age. PMID:26668783</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/21220281','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/21220281"><span id="translatedtitle">Exoplanets: the quest for Earth <span class="hlt">twins</span>.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Mayor, Michel; Udry, Stephane; Pepe, Francesco; Lovis, Christophe</p> <p>2011-02-13</p> <p>Today, more than 400 extra-solar planets have been discovered. They provide strong constraints on the structure and formation mechanisms of planetary systems. Despite this huge amount of data, we still have little information concerning the constraints for extra-terrestrial life, i.e. the frequency of Earth <span class="hlt">twins</span> in the habitable zone and the distribution of their orbital eccentricities. On the other hand, these latter questions strongly excite general interest and trigger future searches for life in the Universe. The status of the extra-solar planets field--in particular with respect to very-low-mass planets--will be discussed and an outlook on the search for Earth <span class="hlt">twins</span> will be given in this paper. PMID:21220281</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/26668783','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/26668783"><span id="translatedtitle">Infantile systemic hyalinosis in identical <span class="hlt">twins</span>.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Koonuru, Mahesh Kumar; Venugopal, Satya Prasad</p> <p>2015-11-01</p> <p>Infantile systemic hyalinosis (ISH) is a rare disorder belonging to the heterogeneous group of genetic fibromatoses. It is a rare, progressive, fatal autosomal recessive condition characterized by widespread deposition of hyaline material in many tissues caused by mutations in the anthrax toxin receptor 2 gene - ANTXR2. It presents hyperpigmented skin over bony prominences. Characteristic purplish patches develop over the medial and lateral malleoli of the ankles, the metacarpophalangeal joints, spine and elbows, with progressive joint contractures, osteopenia, skin abnormalities and chronic severe pain. The present case reports the occurrence of infantile systemic hyalinosis in <span class="hlt">twin</span> brothers five months of age who had come for early intervention for joint contractures representing characteristic brownish patches over bony prominences. ISH cases reported until this date have been less than 20 and the present case is unique in nature since this is the first time ISH is reported in <span class="hlt">twins</span> globally and the symptoms have been identified at an early age. PMID:26668783</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li class="active"><span>23</span></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li><a href="#" onclick='return showDiv("page_25");'>25</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_23 --> <div id="page_24" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li class="active"><span>24</span></li> <li><a href="#" onclick='return showDiv("page_25");'>25</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="461"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/23379198','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/23379198"><span id="translatedtitle">[Interstitial laser coagulation in <span class="hlt">Twin</span> Reversed Arterial Perfusion sequence].</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Wegrzyn, Piotr; Borowski, Dariusz; Nowacka, Elzbieta; Bomba-Opo?, Dorota; Kosi?ska-Kaczy?ska, Katarzyna; Kociszewska-Najman, Bozena; Wielgo?, Miros?aw</p> <p>2012-11-01</p> <p><span class="hlt">Twin</span> Reversed Arterial Perfusion (TRAP) sequence complicates about 1% of all monochorionic <span class="hlt">twin</span> pregnancies and about 1 to 35000 of all pregnancies. It involves an acardiac <span class="hlt">twin</span> whose structural defects are incompatible with life, and an otherwise normal "pump" co-<span class="hlt">twin</span>. As the blood flow in the acardiac <span class="hlt">twin</span> is reversed, it keeps on growing owing to the oxygenated blood from the co-<span class="hlt">twin</span>. Here we report a case of monochorionic, diamniotic <span class="hlt">twin</span> pregnancy after ICS/-ET complicated with TRAP sequence, diagnosed at 11 weeks of pregnancy The unusual finding in this case was the residual heart in the so called acardiac <span class="hlt">twin</span>. Gradually the normal <span class="hlt">twin</span> developed signs of hemodynamic compromise. Reversed a-wave in ductus venosus was observed. The acardiac <span class="hlt">twin</span> showed subcutaneous oedema. On 24 November 2011 a successful interstitial ultrasound-guided laser coagulation was performed at 16 weeks of gestation. 17G needle and 0.6 mm laser fibre were used. The needle was introduced into the pelvic region of the acardiac <span class="hlt">twin</span> through the abdominal wall. A series of laser bursts lasting 5-10 seconds were fired, until cessation of blood flow in the pelvic vessels and umbilical cord of the acardiac <span class="hlt">twin</span> was confirmed using colour Doppler. The course of the intervention was uneventful. Routine steroid therapy was administered at 27 weeks of gestation. At 32 weeks the patient was hospitalized and oral antibiotics were administered due to premature rupture of the membranes and suspicion of intrauterine growth retardation of the pump <span class="hlt">twin</span>. The patient delivered spontaneously at completed 33 weeks of pregnancy (weight 1805g, Apgar 10). After the delivery a stage 2 intraventricular hemorrhage and jaundice were observed in the neonate. Phototherapy was administered and the mother and the child were eventually discharged from the hospital, both in good general condition. Since then, two more successful interstitial laser coagulations in TRAP sequence were performed in our institution. The essence of the treatment of TRAP sequence is cessation of the blood flow from the pump to the acardiac <span class="hlt">twin</span>. Fetoscopic cord ligature or coagulation, and laser or radiofreqency ablations of the acardiac <span class="hlt">twin</span> vessels, are the possible methods of intervention. The interstitial laser coagulation of the acardiac <span class="hlt">twin</span> is less invasive than fetoscopic umbilical cord coagulation, as the outer diameter of the 17G needle is much smaller. A meticulous comparison of these methods would require a randomised study but at 16 weeks of MCDA <span class="hlt">twin</span> pregnancy interstitial laser coagulation seems to be the method of choice. The outcome of the procedure and possible treatment options in case of TRAP together with the review of literature, are presented in the article. PMID:23379198</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/biblio/254378','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/biblio/254378"><span id="translatedtitle">Two <span class="hlt">sisters</span> with clinical diagnosis of Wiskott-Aldrich Syndrome: Is the condition in the family autosomal recessive?</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Kondoh, T.; Hayashi, K.; Matsumoto, T.</p> <p>1995-10-09</p> <p>We report two <span class="hlt">sisters</span> in a family representing manifestations of Wiskott-Aldrich syndrome (WAS), an X-linked immunodeficiency disorder. An elder <span class="hlt">sister</span> had suffered from recurrent infections, small thrombocytopenic petechiae, purpura, and eczema for 7 years. The younger <span class="hlt">sister</span> had the same manifestations as the elder <span class="hlt">sister`s</span> for a 2-year period, and died of intracranial bleeding at age 2 years. All the laboratory data of the two patients were compatible with WAS, although they were females. Sialophorin analysis with the selective radioactive labeling method of this protein revealed that in the elder <span class="hlt">sister</span> a 115-KD band that should be specific for sialophorin was reduced in quantity, and instead an additional 135-KD fragment was present as a main band. Polymerase chain reaction (PCR) analysis of the sialophorin gene and single-strand conformation polymorphism (SSCP) analysis of the PCR product demonstrated that there were no detectable size-change nor electrophoretic mobility change in the DNA from both patients. The results indicated that their sialophorin gene structure might be normal. Studies on the mother-daughter transmission of X chromosome using a pERT84-MaeIII polymorphic marker mapped at Xp21 and HPRT gene polymorphism at Xq26 suggested that each <span class="hlt">sister</span> had inherited a different X chromosome from the mother. Two explanations are plausible for the occurrence of the WAS in our patients: the WAS in the patients is attributable to an autosomal gene mutation which may regulate the sialophorin gene expression through the WAS gene, or, alternatively, the condition in this family is an autosomal recessive disorder separated etiologically from the X-linked WAS. 17 refs., 6 figs., 1 tab.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4263994','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4263994"><span id="translatedtitle">Osteosarcoma in identical <span class="hlt">twins</span>: A case report</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Biazzo, Alessio; De Paolis, Massimiliano; Righi, Alberto; Lana, Debora; Donati, Davide Maria</p> <p>2014-01-01</p> <p>Osteosarcoma (OS) is the most frequent primary malignant bone tumor, if we exclude myeloma, a hematologic systemic disease. OS is relatively uncommon, with an estimated incidence of 600 cases per year in the United States. Among siblings is an even rarer phenomenon, with scattered reports throughout the English literature1. We report the incidence of OS in identical <span class="hlt">twins</span>. The first case is a low-grade OS arisen in the proximal tibia of a 25-year-old man, treated with en-bloc resection and reconstruction with allograft. The second one is a high-grade OS of the distal tibia of the 33-year-old <span class="hlt">twin</span>, developed in a previous non-ossifying fibroma (NOF) followed over the time. The patient was treated with neo-adjuvant chemotherapy, en-bloc resection and reconstruction with allograft. Our literature review did not find any case of OS in identical <span class="hlt">twins</span>, while 26 reports of OS in siblings are described. PMID:25983508</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://ntrs.nasa.gov/search.jsp?R=20010085802&hterms=diabetes+children&qs=N%3D0%26Ntk%3DAll%26Ntx%3Dmode%2Bmatchall%26Ntt%3Ddiabetes%2Bchildren','NASA-TRS'); return false;" href="http://ntrs.nasa.gov/search.jsp?R=20010085802&hterms=diabetes+children&qs=N%3D0%26Ntk%3DAll%26Ntx%3Dmode%2Bmatchall%26Ntt%3Ddiabetes%2Bchildren"><span id="translatedtitle"><span class="hlt">Healthy</span> People 2010</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Angotti, Catherine M.</p> <p>2001-01-01</p> <p>Major <span class="hlt">Healthy</span> People (HP) 2000 goals closely tied to prevention were not met nationally: physical activity did not improve; evidence that it actually decreased; obesity did not decrease but instead increased in all groups, actually doubling in children; and incidence of type 2 diabetes did not decrease, but instead evidence showed that it increased in all age groups.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=diaper&pg=4&id=ED335118','ERIC'); return false;" href="http://eric.ed.gov/?q=diaper&pg=4&id=ED335118"><span id="translatedtitle">Keeping Kids <span class="hlt">Healthy</span>.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Mays, Sharon; And Others</p> <p></p> <p>This pamphlet offers a collection of items relating to child health in the day care setting. Included is an overview of a collaborative project to develop a comprehensive set of national standards for health, nutrition, safety, and sanitation in child care programs. Contents of the project's resource kit, "Keeping Kids <span class="hlt">Healthy</span> and Parents at…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.lung.org/our-initiatives/healthy-air/outdoor/','NIH-MEDLINEPLUS'); return false;" href="http://www.lung.org/our-initiatives/healthy-air/outdoor/"><span id="translatedtitle"><span class="hlt">Healthy</span> Air Outdoors</span></a></p> <p><a target="_blank" href="http://medlineplus.gov/">MedlinePLUS</a></p> <p></p> <p></p> <p>... families and can even shorten their lives. Outdoor Air Pollution and Health Outdoor air pollution continues to threaten the lives and health of ... sources such as fires and dust contribute to air pollution. Learn more Fighting for <span class="hlt">Healthy</span> Air The American ...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/biblio/982005','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/biblio/982005"><span id="translatedtitle">Tensile and compressive mechanical behavior of <span class="hlt">twinned</span> silicon carbide nanowires</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Wang, Zhiguo; Li, Jingbo; Gao, Fei; Weber, William J.</p> <p>2010-04-01</p> <p>Molecular dynamics simulations with the Tersoff potential were used to study the response of <span class="hlt">twinned</span> SiC nanowires under tensile and compressive strains. The critical strain of the <span class="hlt">twinned</span> nanowires can be enhanced by <span class="hlt">twin</span>-stacking faults, and their critical strains are larger than those of perfect nanowires with the same diameters. Under axial tensile strain, the bonds of the nanowires are just stretched before failure. The failure behavior is found to depend on the <span class="hlt">twin</span> segment thickness and the diameter of the nanowires. An atomic chain is observed for the thin nanowires with small <span class="hlt">twin</span> segment thickness under tension strain. Under axial compressive strain, the collapse of the <span class="hlt">twinned</span> SiC nanowires exhibits two differently failure modes, depending on the length and diameter of the nanowires, i.e. shell buckling for short length nanowires and columnar buckling for longer length nanowires.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4265630','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4265630"><span id="translatedtitle">Hirschsprung’s disease in <span class="hlt">twin</span> to <span class="hlt">twin</span> transfusion syndrome: A case report</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Park, Hye Won; Cho, Min Jeng; Kim, Wook Youn; Kwak, Byung Ok; Kim, Min Hee</p> <p>2014-01-01</p> <p><span class="hlt">Twin</span> to <span class="hlt">twin</span> transfusion syndrome (TTTS) is caused by aberrant vascular connections between infant <span class="hlt">twins</span> and results in high morbidity and mortality in the perinatal period. In donor infants with TTTS and symptoms of intestinal obstruction, small-bowel lesions have been reported in most cases. We report on a 33+6 gestational wk donor infant with TTTS who had intermittent obstructive episodes, including delayed meconium passage and colonic dilatation on abdominal X-ray. The diagnosis of Hirschsprung’s disease was based on a lateral pelvic film with a reversed rectosigmoid ratio. A subsequent barium colon study and rectal suction biopsy indicated a short segment aganglionosis of the colon. PMID:25516683</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3261041','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3261041"><span id="translatedtitle">Resurrection of the genus Staphisagria J. Hill, <span class="hlt">sister</span> to all the other Delphinieae (Ranunculaceae)</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Jabbour, Florian; Renner, Susanne S.</p> <p>2011-01-01</p> <p>Abstract Molecular sequence data show that the three species oDelphinium subg. Staphisagria (J. Hill) Peterm. form the <span class="hlt">sister</span> clade to Aconitum L., Aconitella SpachConsolida (DC.) S.F. Gray, and all remaining species of Delphinium L. To account for this finding we resurrect Staphisagria J. Hill (1756). Names in Staphisagria are available for two of the species. We here make the required new combination for the third species, Staphisagria picta (Willd.) F. Jabbour, provide a key to the species, and illustrate one of them. PMID:22287922</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/9473855','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/9473855"><span id="translatedtitle">Induction of <span class="hlt">sister</span>-chromatid exchange by ethylene glycol monomethylether and its metabolite.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Arashidani, K; Kawamoto, T; Kodama, Y</p> <p>1998-01-01</p> <p>The frequency of <span class="hlt">sister</span>-chromatid exchange (SCE) induced by ethylene glycol monomethylether (EGME) and methoxyacetic acid (MAA), a major metabolite of EGME, was determined in human peripheral blood, and for EGME in mouse bone marrow cells. In the experiment on the human peripheral blood, the induction of SCE was observed after the addition of MAA to the culture medium, but not after the addition of EGME. However, EGME induced SCE in the mouse bone marrow cells, when administered by intraperitoneal injection. These results suggested that EGME did not induce SCE itself, but that MAA, one of the major metabolites of EGME induces SCE. PMID:9473855</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015MPLA...3050168K','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015MPLA...3050168K"><span id="translatedtitle">The aging problem of <span class="hlt">twins</span> in the ellipsoidal coordinates</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Kumar, Himanshu; Singh, J. K.</p> <p>2015-09-01</p> <p>In this paper, we have tried to explore the <span class="hlt">twin</span> paradox in the ellipsoidal coordinate system. We have investigated that the traveling <span class="hlt">twin</span> travels away from the gravitational source in the first case while in the other it moves towards the source. We then tried to compare it with the special relativistic case where the static <span class="hlt">twin</span> ages faster as compared to his traveling counterpart.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://ntrs.nasa.gov/search.jsp?R=19790067684&hterms=crystallography&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D30%26Ntt%3Dcrystallography','NASA-TRS'); return false;" href="http://ntrs.nasa.gov/search.jsp?R=19790067684&hterms=crystallography&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D30%26Ntt%3Dcrystallography"><span id="translatedtitle">Crystallography of decahedral and icosahedral particles. I - Geometry of <span class="hlt">twinning</span></span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Yang, C. Y.</p> <p>1979-01-01</p> <p>The crystal structure of the tetrahedral <span class="hlt">twins</span> in multiply-<span class="hlt">twinned</span> particles with decahedral and icosahedral point group symmetries has been examined and correlated with the face-centered cubic structure. Details on the crystal structure as well as the geometrical relationships among <span class="hlt">twins</span> in each particle are presented. These crystallographic facts serve as a basis for the interpretation of small particle images obtained with advanced methods of transmission electron microscopy.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015A%26A...574A.124D','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015A%26A...574A.124D"><span id="translatedtitle">Spectroscopic study of solar <span class="hlt">twins</span> and analogues</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Datson, Juliet; Flynn, Chris; Portinari, Laura</p> <p>2015-02-01</p> <p>Context. Many large stellar surveys have been and are still being carried out, providing huge amounts of data, for which stellar physical parameters will be derived. Solar <span class="hlt">twins</span> and analogues provide a means to test the calibration of these stellar catalogues because the Sun is the best-studied star and provides precise fundamental parameters. Solar <span class="hlt">twins</span> should be centred on the solar values. Aims: This spectroscopic study of solar analogues selected from the Geneva-Copenhagen Survey (GCS) at a resolution of 48 000 provides effective temperatures and metallicities for these stars. We test whether our spectroscopic parameters, as well as the previous photometric calibrations, are properly centred on the Sun. In addition, we search for more solar <span class="hlt">twins</span> in our sample. Methods: The methods used in this work are based on literature methods for solar <span class="hlt">twin</span> searches and on methods we developed in previous work to distinguish the metallicity-temperature degeneracies in the differential comparison of spectra of solar analogues versus a reference solar reflection spectrum. Results: We derive spectroscopic parameters for 148 solar analogues (about 70 are new entries to the literature) and verify with a-posteriori differential tests that our values are well-centred on the solar values. We use our dataset to assess the two alternative calibrations of the GCS parameters; our methods favour the latest revision. We show that the choice of spectral line list or the choice of asteroid or time of observation does not affect the results. We also identify seven solar <span class="hlt">twins</span> in our sample, three of which are published here for the first time. Conclusions: Our methods provide an independent means to differentially test the calibration of stellar catalogues around the values of a well-known benchmark star, which makes our work interesting for calibration tests of upcoming Galactic surveys. Based on observations made with ESO Telescopes at the La Silla Observatory under programme ID 077.D-0525 and 090.D-0133.Table 1 is also available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/574/A124Full Table 5 is only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/574/A124</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/23857518','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/23857518"><span id="translatedtitle">Discordant transsexualism in male monozygotic <span class="hlt">twins</span>: neuroanatomical and psychological differences.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Andreazza, Tahiana Signorini; Costa, Angelo Brandelli; Massuda, Raffael; Salvador, Jaqueline; Silveira, Esalba Maria; Piccon, Felipe; Carvalho, Renata; Fontanari, Anna Martha Vaitses; Koff, Walter; Belmonte-de-Abreu, Paulo; Lobato, Maria Inês Rodrigues</p> <p>2014-02-01</p> <p>One monozygotic male <span class="hlt">twin</span> pair discordant for transsexualism is described. Both <span class="hlt">twins</span> were interviewed and tested with the Wechsler Adult Intelligence Scale battery for cognitive functions and they underwent magnetic resonance imaging to measure the volumes of specific cerebral structures. Interviews with the <span class="hlt">twins</span> and their mother indicated no unusual medical or life history events that could have had a causal role in the emergence of the disorder. Both cognitive function testing and neuroimaging detected differences between the <span class="hlt">twins</span> that could be related to unexplained epigenetic effects and exogenous hormone usage. PMID:23857518</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/1990PCM....17..207T','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/1990PCM....17..207T"><span id="translatedtitle">Structure of Brazil <span class="hlt">twin</span> boundaries in amethyst showing brewster fringes</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Taijing, Lu; Sunagawa, Ichiro</p> <p>1990-06-01</p> <p>Optical investigations of Brewster fringes in natural amethyst crystals have indicated that the fringes are Brazil <span class="hlt">twin</span> boundaries consisting of McLaren and Pitkethly type zig-zag structures and closed parallelograms. The two types of Brazil <span class="hlt">twin</span> boundaries appear alternately in the successive fringes and in different orientations in one fringe. The Brewster fringes develop by a process of incorporation of many Brazil <span class="hlt">twin</span> lamellae, when growth conditions are stabilized after this process. If perturbation occurs in growth conditions, distinct growth banding with and without Brazil <span class="hlt">twin</span> lamellae will develop, and not Brewster fringes.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/11996188','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/11996188"><span id="translatedtitle">Extracting <span class="hlt">twins</span> from orientation imaging microscopy scan data.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Wright, S I; Larsen, R J</p> <p>2002-03-01</p> <p>Automated electron backscatter diffraction or orientation imaging microscopy (OIM) provides spatially specific measurements of crystallographic orientation. These measurements are typically collected on regular grids. By inspecting the misorientation between neighbouring measurements on the grid, potential <span class="hlt">twin</span> boundaries can be identified. If the misorientation is within some given tolerance of a specified <span class="hlt">twin</span> misorientation, the boundary separating the two measurements may be identified as a potential <span class="hlt">twin</span> boundary. In addition, for a coherent <span class="hlt">twin</span>, the <span class="hlt">twinning</span> planes must be coincident with the grain boundary plane. As OIM scans are inherently two-dimensional, the scan data provide only limited information on the boundary plane. Thus, it is not possible to ascertain definitively whether the <span class="hlt">twinning</span> planes are coincident with the boundary plane. Nonetheless, the alignment of the surface traces of the <span class="hlt">twinning</span> planes with the trace of the boundary provides a partial indication of coincidence. An automated approach has been developed that allows data concerning both <span class="hlt">twin</span> criterion to be extracted from OIM scans. Application of the methodology to deformed zirconium suggests that the <span class="hlt">twinning</span> planes remain coherent during deformation. The methodology was also used to improve grain size distributions measured by OIM. These results more closely match those obtained by conventional metallography. PMID:11996188</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/servlets/purl/976147','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/servlets/purl/976147"><span id="translatedtitle">Advanced characterization of <span class="hlt">twins</span> using automated electron backscatter diffraction</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Wright, S. I.; Bingert, J. F.; Mason, T. A.; Larson, R. J.</p> <p>2002-01-01</p> <p>This paper describes results obtained using an automated, crystallographically-based technique for <span class="hlt">twin</span> identification. The technique is based on the automated collection of spatially specific orientation measurements by electron backscatter diffraction (EBSD) in the scanning electron microscope (SEM). The key features of the analysis are identification of potential <span class="hlt">twin</span> boundaries by their misorientation character, identification of the distinct boundary planes among the symmetrically equivalent candidates, and validation of these boundaries through comparison with the boundary and <span class="hlt">twin</span> plane traces in the sample cross section. Results on the application of this technique to deformation <span class="hlt">twins</span> in zirconium are analyzed for the effect of <span class="hlt">twin</span> type and amount and sense of uniaxial deformation. The accumulation of strain tends to increase the misorientation deviation at least to the degree of the trace deviation compared with recrystallization <span class="hlt">twins</span> in nickel. In addition to the results on characterizing the <span class="hlt">twin</span> character, results on extending the <span class="hlt">twin</span> analysis to automated identification of parent and daughter material for structures exhibiting <span class="hlt">twin</span> deformation are reported as well.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://biology.ucsd.edu/labs/markow/documents/dermatoglyphicinpsychotictwins.pdf','EPRINT'); return false;" href="http://biology.ucsd.edu/labs/markow/documents/dermatoglyphicinpsychotictwins.pdf"><span id="translatedtitle">Ps.vchiatry Research, 29~3743 Fluctuating Dermatoglyphic Asymmetry in Psychotic <span class="hlt">Twins</span></span></a></p> <p><a target="_blank" href="http://www.osti.gov/eprints/">E-print Network</a></p> <p>Markow, Therese</p> <p></p> <p>should be associated with greater fluctuating asymmetry in <span class="hlt">twin</span> pairs in which both <span class="hlt">twins</span> are mentally ill compared to <span class="hlt">twin</span> pairs in which one individual is normal. Our analysis of asymmetry for finger</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.gpo.gov:80/fdsys/pkg/FR-2012-08-13/pdf/2012-19794.pdf','FEDREG'); return false;" href="http://www.gpo.gov:80/fdsys/pkg/FR-2012-08-13/pdf/2012-19794.pdf"><span id="translatedtitle">77 FR 48168 - Call for Nominations for the <span class="hlt">Twin</span> Falls District Resource Advisory Council</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collection.action?collectionCode=FR">Federal Register 2010, 2011, 2012, 2013, 2014</a></p> <p></p> <p>2012-08-13</p> <p>...00] Call for Nominations for the <span class="hlt">Twin</span> Falls District Resource Advisory Council AGENCY...ACTION: Call for Nominations, <span class="hlt">Twin</span> Falls District Resource Advisory Council...nominations to fill one position on the <span class="hlt">Twin</span> Falls District Resource Advisory Council...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.gpo.gov:80/fdsys/pkg/FR-2012-05-15/pdf/2012-11716.pdf','FEDREG'); return false;" href="http://www.gpo.gov:80/fdsys/pkg/FR-2012-05-15/pdf/2012-11716.pdf"><span id="translatedtitle">77 FR 28619 - Notice of Public Meetings, <span class="hlt">Twin</span> Falls District Resource Advisory Council, Idaho</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collection.action?collectionCode=FR">Federal Register 2010, 2011, 2012, 2013, 2014</a></p> <p></p> <p>2012-05-15</p> <p>...00] Notice of Public Meetings, <span class="hlt">Twin</span> Falls District Resource Advisory Council, Idaho...Bureau of Land Management (BLM) <span class="hlt">Twin</span> Falls District Resource Advisory Council (RAC...below. DATES: On June 5, 2012, the <span class="hlt">Twin</span> Falls District RAC subcommittee members for...</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li class="active"><span>24</span></li> <li><a href="#" onclick='return showDiv("page_25");'>25</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_24 --> <div id="page_25" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li class="active"><span>25</span></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="481"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.gpo.gov:80/fdsys/pkg/FR-2012-07-24/pdf/2012-17992.pdf','FEDREG'); return false;" href="http://www.gpo.gov:80/fdsys/pkg/FR-2012-07-24/pdf/2012-17992.pdf"><span id="translatedtitle">77 FR 43353 - Notice of Public Meetings, <span class="hlt">Twin</span> Falls District Resource Advisory Council, Idaho</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collection.action?collectionCode=FR">Federal Register 2010, 2011, 2012, 2013, 2014</a></p> <p></p> <p>2012-07-24</p> <p>...00] Notice of Public Meetings, <span class="hlt">Twin</span> Falls District Resource Advisory Council, Idaho...Bureau of Land Management (BLM) <span class="hlt">Twin</span> Falls District Resource Advisory Council (RAC...DATES: On August 16, 2012, the <span class="hlt">Twin</span> Falls District RAC subcommittee members for...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.gpo.gov:80/fdsys/pkg/FR-2012-03-15/pdf/2012-6252.pdf','FEDREG'); return false;" href="http://www.gpo.gov:80/fdsys/pkg/FR-2012-03-15/pdf/2012-6252.pdf"><span id="translatedtitle">77 FR 15388 - Notice of Public Meetings, <span class="hlt">Twin</span> Falls District Resource Advisory Council, Idaho</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collection.action?collectionCode=FR">Federal Register 2010, 2011, 2012, 2013, 2014</a></p> <p></p> <p>2012-03-15</p> <p>...00] Notice of Public Meetings, <span class="hlt">Twin</span> Falls District Resource Advisory Council, Idaho...Bureau of Land Management (BLM) <span class="hlt">Twin</span> Falls District Resource Advisory Council (RAC...DATES: On March 28, 2012, the <span class="hlt">Twin</span> Falls District RAC subcommittee members for...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.gpo.gov:80/fdsys/pkg/FR-2010-08-11/pdf/2010-19770.pdf','FEDREG'); return false;" href="http://www.gpo.gov:80/fdsys/pkg/FR-2010-08-11/pdf/2010-19770.pdf"><span id="translatedtitle">75 FR 48723 - Notice of Public Meetings, <span class="hlt">Twin</span> Falls District Resource Advisory Council, Idaho</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collection.action?collectionCode=FR">Federal Register 2010, 2011, 2012, 2013, 2014</a></p> <p></p> <p>2010-08-11</p> <p>...00] Notice of Public Meetings, <span class="hlt">Twin</span> Falls District Resource Advisory Council, Idaho...Bureau of Land Management (BLM) <span class="hlt">Twin</span> Falls District Resource Advisory Council (RAC...DATES: On September 9, 2010, the <span class="hlt">Twin</span> Falls District RAC subcommittee members...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.gpo.gov:80/fdsys/pkg/FR-2010-09-30/pdf/2010-24481.pdf','FEDREG'); return false;" href="http://www.gpo.gov:80/fdsys/pkg/FR-2010-09-30/pdf/2010-24481.pdf"><span id="translatedtitle">75 FR 60477 - Notice of Public Meetings, <span class="hlt">Twin</span> Falls District Resource Advisory Council, Idaho</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collection.action?collectionCode=FR">Federal Register 2010, 2011, 2012, 2013, 2014</a></p> <p></p> <p>2010-09-30</p> <p>...00] Notice of Public Meetings, <span class="hlt">Twin</span> Falls District Resource Advisory Council, Idaho...Bureau of Land Management (BLM) <span class="hlt">Twin</span> Falls District Resource Advisory Council (RAC...2010; and December 1, 2010. The <span class="hlt">Twin</span> Falls District RAC subcommittee members...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.gpo.gov:80/fdsys/pkg/FR-2012-06-22/pdf/2012-15331.pdf','FEDREG'); return false;" href="http://www.gpo.gov:80/fdsys/pkg/FR-2012-06-22/pdf/2012-15331.pdf"><span id="translatedtitle">77 FR 37705 - Notice of Public Meetings, <span class="hlt">Twin</span> Falls District Resource Advisory Council, Idaho</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collection.action?collectionCode=FR">Federal Register 2010, 2011, 2012, 2013, 2014</a></p> <p></p> <p>2012-06-22</p> <p>...00] Notice of Public Meetings, <span class="hlt">Twin</span> Falls District Resource Advisory Council, Idaho...Bureau of Land Management (BLM) <span class="hlt">Twin</span> Falls District Resource Advisory Council (RAC...DATES: On July 10, 2012, the <span class="hlt">Twin</span> Falls District RAC subcommittee members for...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.gpo.gov:80/fdsys/pkg/FR-2010-12-23/pdf/2010-32323.pdf','FEDREG'); return false;" href="http://www.gpo.gov:80/fdsys/pkg/FR-2010-12-23/pdf/2010-32323.pdf"><span id="translatedtitle">75 FR 80839 - Notice of Public Meetings, <span class="hlt">Twin</span> Falls District Resource Advisory Council, Idaho</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collection.action?collectionCode=FR">Federal Register 2010, 2011, 2012, 2013, 2014</a></p> <p></p> <p>2010-12-23</p> <p>...00] Notice of Public Meetings, <span class="hlt">Twin</span> Falls District Resource Advisory Council, Idaho...Bureau of Land Management (BLM) <span class="hlt">Twin</span> Falls District Resource Advisory Council (RAC...2011. On January 12, 2011, the <span class="hlt">Twin</span> Falls District RAC subcommittee members...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.gpo.gov:80/fdsys/pkg/FR-2011-03-25/pdf/2011-7073.pdf','FEDREG'); return false;" href="http://www.gpo.gov:80/fdsys/pkg/FR-2011-03-25/pdf/2011-7073.pdf"><span id="translatedtitle">76 FR 16809 - Notice of Public Meetings, <span class="hlt">Twin</span> Falls District Resource Advisory Council, Idaho</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collection.action?collectionCode=FR">Federal Register 2010, 2011, 2012, 2013, 2014</a></p> <p></p> <p>2011-03-25</p> <p>...00] Notice of Public Meetings, <span class="hlt">Twin</span> Falls District Resource Advisory Council, Idaho...Bureau of Land Management (BLM) <span class="hlt">Twin</span> Falls District Resource Advisory Council (RAC...2011. On April 27, 2011, the <span class="hlt">Twin</span> Falls District RAC members will meet at the...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3208311','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3208311"><span id="translatedtitle">Non-redundant odor coding by <span class="hlt">sister</span> mitral cells revealed by light addressable glomeruli in the mouse</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Dhawale, Ashesh K.; Hagiwara, Akari; Bhalla, Upinder S.; Murthy, Venkatesh N.; Albeanu, Dinu F.</p> <p>2011-01-01</p> <p>Sensory inputs frequently converge on the brain in a spatially organized manner, often with overlapping inputs to multiple target neurons. Whether the responses of target neurons with common inputs become decorrelated depends on the contribution of local circuit interactions. We addressed this issue in the olfactory system using newly generated transgenic mice expressing channelrhodopsin-2 in all olfactory sensory neurons. By selectively stimulating individual glomeruli with light, we identified mitral/tufted (M/T) cells that receive common input (<span class="hlt">sister</span> cells). <span class="hlt">Sister</span> M/T cells had highly correlated responses to odors as measured by average spike rates, but their spike timing in relation to respiration was differentially altered. In contrast, non-<span class="hlt">sister</span> M/T cells correlated poorly on both these measures. We suggest that <span class="hlt">sister</span> M/T cells carry two different channels of information: average activity representing shared glomerular input, and phase-specific information that refines odor representations and is substantially independent for <span class="hlt">sister</span> M/T cells. PMID:20953197</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3685581','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3685581"><span id="translatedtitle">Genomic basis of ecological niche divergence among cryptic <span class="hlt">sister</span> species of non-biting midges</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p></p> <p>2013-01-01</p> <p>Background There is a lack of understanding the evolutionary forces driving niche segregation of closely related organisms. In addition, pinpointing the genes driving ecological divergence is a key goal in molecular ecology. Here, larval transcriptome sequences obtained by next-generation-sequencing are used to address these issues in a morphologically cryptic <span class="hlt">sister</span> species pair of non-biting midges (Chironomus riparius and C. piger). Results More than eight thousand orthologous open reading frames were screened for interspecific divergence and intraspecific polymorphisms. Despite a small mean sequence divergence of 1.53% between the <span class="hlt">sister</span> species, 25.1% of 18,115 observed amino acid substitutions were inferred by ? statistics to be driven by positive selection. Applying McDonald-Kreitman tests to 715 alignments of gene orthologues identified eleven (1.5%) genes driven by positive selection. Conclusions Three candidate genes were identified as potentially responsible for the observed niche segregation concerning nitrite concentration, habitat temperature and water conductivity. Additionally, signs of positive selection in the hydrogen sulfide detoxification pathway were detected, providing a new plausible hypothesis for the species’ ecological differentiation. Finally, a divergently selected, nuclear encoded mitochondrial ribosomal protein may contribute to reproductive isolation due to cytonuclear coevolution. PMID:23758757</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1470745','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1470745"><span id="translatedtitle">Meiotic recombination between paralogous RBCSB genes on <span class="hlt">sister</span> chromatids of Arabidopsis thaliana.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Jelesko, John G; Carter, Kristy; Thompson, Whitney; Kinoshita, Yuki; Gruissem, Wilhelm</p> <p>2004-01-01</p> <p>Paralogous genes organized as a gene cluster can rapidly evolve by recombination between misaligned paralogs during meiosis, leading to duplications, deletions, and novel chimeric genes. To model unequal recombination within a specific gene cluster, we utilized a synthetic RBCSB gene cluster to isolate recombinant chimeric genes resulting from meiotic recombination between paralogous genes on <span class="hlt">sister</span> chromatids. Several F1 populations hemizygous for the synthRBCSB1 gene cluster gave rise to Luc+ F2 plants at frequencies ranging from 1 to 3 x 10(-6). A nonuniform distribution of recombination resolution sites resulted in the biased formation of recombinant RBCS3B/1B::LUC genes with nonchimeric exons. The positioning of approximately half of the mapped resolution sites was effectively modeled by the fractional length of identical DNA sequences. In contrast, the other mapped resolution sites fit an alternative model in which recombination resolution was stimulated by an abrupt transition from a region of relatively high sequence similarity to a region of low sequence similarity. Thus, unequal recombination between paralogous RBCSB genes on <span class="hlt">sister</span> chromatids created an allelic series of novel chimeric genes that effectively resulted in the diversification rather than the homogenization of the synthRBCSB1 gene cluster. PMID:15020479</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://pubs.er.usgs.gov/publication/70059646','USGSPUBS'); return false;" href="http://pubs.er.usgs.gov/publication/70059646"><span id="translatedtitle">“Our vanishing glaciers”: One hundred years of glacier retreat in Three <span class="hlt">Sisters</span> Area, Oregon Cascade Range</span></a></p> <p><a target="_blank" href="http://pubs.er.usgs.gov/pubs/index.jsp?view=adv">USGS Publications Warehouse</a></p> <p>O'Connor, James E.</p> <p>2014-01-01</p> <p>In August 1910, thirty-nine members of the Mazamas Mountaineering Club ascended the peaks of the Three <span class="hlt">Sisters</span> in central Oregon. While climbing, geologist Ira A. Williams photographed the surrounding scenery, including images of Collier Glacier. One hundred years later, U.S. Geological Survey research hydrologist Jim E. O’Connor matched those documented photographs with present day images — the result of which is a stunning lapse of glacial change in the Three <span class="hlt">Sister</span> region. O’Connor asserts that “glaciers exist by the grace of climate,” and through a close examination of the history of the region’s glaciers, he provides an intriguing glimpse into the history of geological surveys and glacial studies in the Pacific Northwest, including their connection to significant scientific advances of the nineteenth century. The work of scientists and mountaineers who have monitored and recorded glacier changes for over a century allows us to see dramatic changes in a landscape that is especially sensitive to ongoing climate change.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/25640518','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/25640518"><span id="translatedtitle">A novel <span class="hlt">sister</span> clade to the enterobacteria microviruses (family Microviridae) identified in methane seep sediments.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Bryson, Samuel Joseph; Thurber, Andrew R; Correa, Adrienne M S; Orphan, Victoria J; Vega Thurber, Rebecca</p> <p>2015-10-01</p> <p>Methane seep microbial communities perform a key ecosystem service by consuming the greenhouse gas methane prior to its release into the hydrosphere, minimizing the impact of marine methane sources on our climate. Although previous studies have examined the ecology and biochemistry of these communities, none has examined viral assemblages associated with these habitats. We employed virus particle purification, genome amplification, pyrosequencing and gene/genome reconstruction and annotation on two metagenomic libraries, one prepared for ssDNA and the other for all DNA, to identify the viral community in a methane seep. Similarity analysis of these libraries (raw and assembled) revealed a community dominated by phages, with a significant proportion of similarities to the Microviridae family of ssDNA phages. We define these viruses as the Eel River Basin Microviridae (ERBM). Assembly and comparison of 21 ERBM closed circular genomes identified five as members of a novel <span class="hlt">sister</span> clade to the Microvirus genus of Enterobacteria phages. Comparisons among other metagenomes and these Microviridae major-capsid sequences indicated that this clade of phages is currently unique to the Eel River Basin sediments. Given this ERBM clade's relationship to the Microviridae genus Microvirus, we define this <span class="hlt">sister</span> clade as the candidate genus Pequeñovirus. PMID:25640518</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/biblio/5025379','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/biblio/5025379"><span id="translatedtitle">Origins of dacite and rhyodacite of the South <span class="hlt">Sister</span> magmatic system, central high Cascades, Oregon</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Price, J.D.; Parker, D.F. )</p> <p>1993-04-01</p> <p>A gap from 66 to 72 weight percent silica (48--62 ppm Rb) separates dacite from rhyodacite of the South <span class="hlt">Sister</span> system. The authors results indicate that rhyodacite can not be produced by fractional crystallization from dacite. Variation among rhyodacite and associated rhyolite is, however, most likely the result of fractional crystallization, in agreement with previous studies. Dacite in the South <span class="hlt">Sister</span> system probably had multiple origins, as suggested by trace element plots for Y, Nb and Zr. Some dacite was produced by fractional crystallization from andesitic magmas, while others were largely the result of mixing between andesite and rhyodacite. Mafic enclaves occurring in dacite are compositional similar to Holocene basalt, and their mixing with dacitic magma may have triggered eruptions, but they are probably not directly related genetically to their host rocks. The rhyodacites are probably crustal melts. Previous workers have suggested high-level melting of hypabyssal silicic plutons or amphibolite sources for the rhyodacites. The authors suggest melting of granitic plutonic sources, similar to those exposed in the Klamath Mountains, for the origin of the rhyodacites.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://go4life.nia.nih.gov/tip-sheets/what-does-healthy-eating-mean','NIH-MEDLINEPLUS'); return false;" href="https://go4life.nia.nih.gov/tip-sheets/what-does-healthy-eating-mean"><span id="translatedtitle">What Does "<span class="hlt">Healthy</span> Eating" Mean?</span></a></p> <p><a target="_blank" href="http://medlineplus.gov/">MedlinePLUS</a></p> <p></p> <p></p> <p>... Go4Life Get Free Stuff Be a Partner What Does “<span class="hlt">Healthy</span> Eating” Mean? According to the Dietary Guidelines ... vegetables help, too! Download the Tip Sheet What Does “<span class="hlt">Healthy</span> Eating” Mean? (PDF, 513.2 KB) You ...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4303107','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4303107"><span id="translatedtitle"><span class="hlt">Healthy</span> Aging in China</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Smith, James P.; Strauss, John; Zhao, Yaohui</p> <p>2014-01-01</p> <p>China has aged rapidly and the rate is accelerating in decades to come. We review positive and negative forces for <span class="hlt">healthy</span> aging in China now and in the future. The most positive force is the spectacular growth in education over time especially for Chinese women, which should improve all dimensions of cognitive and physical health and eliminate vast gender disparities in <span class="hlt">healthy</span> aging that currently exist. Other positive forces include increasing detection and treatment of disease and the availability of health insurance and health services so that diseases like hypertension and diabetes do not remain silent killers in China. Transparency is eased on the research level by publicly available data such as CHARLS, a sharp departure from prior scientific norm in China. Negative forces center on disturbing trends in personal health behaviors such as growing rates of smoking (among men) and obesity (for both genders), and pollution—,especially in urban centers. Public health campaigns and incentives are needed on all these fronts so that predictable long-term consequences of these behaviors on older age disease are not realized. There will not be a simple demographic fix to <span class="hlt">healthy</span> aging in China as fertility rates are unlikely to rise much, while migration will likely continue to rise leaving growing numbers of elderly parents geographically separated from their adult children. Government policy will have to allow migration of elderly parents to live with their adult children while reducing the rigid connection of policy (health insurance and health services) with place of residence. PMID:25621202</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2006AGUSM.M22A..07Z','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2006AGUSM.M22A..07Z"><span id="translatedtitle">Chemical and Structural Variations at Augite (100) <span class="hlt">Twin</span> Boundaries</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Zhang, S.; Veblen, D. R.</p> <p>2006-05-01</p> <p><span class="hlt">Twins</span> and stacking faults on (100) are far less abundant in calcic pyroxenes like augite than they are in low-Ca compositions, such as pigeonite and orthopyroxene. The paucity of such <span class="hlt">twinning</span> in augite has been attributed to high energies associated with octahedral skew reversals in pyroxenes where the M2 site is occupied by cations larger than Mg or Fe (e.g., Ca, Na). Deformation-<span class="hlt">twin</span> boundaries in augite occurring in a pyroxene granulite from Hamnoy, Lofoten, Norway, were examined using high-resolution transmission electron microscopy. HRTEM images are consistent with Ca depletion at (100) <span class="hlt">twin</span> boundaries, which can be interpreted structurally as a single unit cell of the low-Ca protoenstatite structure, or one-half unit cell of orthopyroxene. The high-resolution images show that the augite (100) <span class="hlt">twin</span> planes are coherent or semi-coherent and are, in some cases, associated with (100) stacking faults. Although some of the <span class="hlt">twin</span> planes have only a single, 0.9-nm layer of Ca-depleted pyroxene, most of them have been replaced by several unit cells of low-Ca clinopyroxene (pigeonite or clinoenstatite) that apparently nucleated on the low-Ca <span class="hlt">twin</span> plane. We predict that future energy-filtered compositional imaging (EFTEM) investigations will confirm that the simple <span class="hlt">twin</span> boundaries are, in fact, depleted in Ca. These nanometer-scale, Ca-depleted <span class="hlt">twin</span> planes, and the pigeonite lamellae that nucleate on them, may result from a protracted thermal high during deformation, or from a later, retrograde metamorphic event experienced by these rocks. The atomic structure at the deformation-<span class="hlt">twin</span> boundaries is topologically identical to that of the (100) herringbone <span class="hlt">twin</span> planes that are found almost universally in augite from basalts and gabbros. Future investigations of (100) <span class="hlt">twin</span> planes in augite from basalts and gabbros therefore should indicate whether or not long annealing times are required for Ca depletion at (100) <span class="hlt">twin</span> planes in high-Ca pyroxenes. These results also suggest that traditional structural models of <span class="hlt">twin</span> boundaries in complex inorganic solids are oversimplified. In cases such as this, chemical diffusion results in a different chemical composition, and, no doubt, in concomitant structural variations in the vicinity of the <span class="hlt">twin</span> plane, compared to that of the host structure.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/26002163','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/26002163"><span id="translatedtitle">What you need to know when managing <span class="hlt">twins</span>: 10 key facts.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Simpson, Lynn L</p> <p>2015-06-01</p> <p><span class="hlt">Twin</span> pregnancies can be complicated. Early diagnosis with accurate dating, determination of chorionicity, screening for chromosomal and structural abnormalities, placental evaluation, and cervical length assessment should be completed in the first half of gestation. Routine fetal growth is recommended for all <span class="hlt">twins</span> with serial surveillance for those complicated by anomalies, cervical shortening, growth disturbances, and amniotic fluid abnormalities. <span class="hlt">Twins</span> with monochorionic placentation require heightened scrutiny for unequal placental sharing with discordant <span class="hlt">twin</span> growth or selective intrauterine fetal growth restriction, <span class="hlt">twin-twin</span> transfusion syndrome, <span class="hlt">twin</span> anemia-polycythemia sequence, and single-fetal demise. Familiarity with essentials can assist practitioners involved in the management of <span class="hlt">twins</span>. PMID:26002163</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/25578775','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/25578775"><span id="translatedtitle">CNV Concordance in 1,097 MZ <span class="hlt">Twin</span> Pairs.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Abdellaoui, Abdel; Ehli, Erik A; Hottenga, Jouke-Jan; Weber, Zachary; Mbarek, Hamdi; Willemsen, Gonneke; van Beijsterveldt, Toos; Brooks, Andrew; Hudziak, Jim J; Sullivan, Patrick F; de Geus, Eco J; Davies, Gareth E; Boomsma, Dorret I</p> <p>2015-02-01</p> <p>Monozygotic (MZ) <span class="hlt">twins</span> are genetically identical at conception, making them informative subjects for studies on somatic mutations. Copy number variants (CNVs) are responsible for a substantial part of genetic variation, have relatively high mutation rates, and are likely to be involved in phenotypic variation. We conducted a genome-wide survey for post-<span class="hlt">twinning</span> de novo CNVs in 1,097 MZ <span class="hlt">twin</span> pairs. Comparisons between MZ <span class="hlt">twins</span> were made by CNVs measured in DNA from blood or buccal epithelium with the Affymetrix 6.0 microarray and two calling algorithms. In addition, CNV concordance rates were compared between the different sources of DNA, and gene-enrichment association analyses were conducted for thought problems (TP) and attention problems (AP) using CNVs concordant within MZ pairs. We found a total of 153 putative post-<span class="hlt">twinning</span> de novo CNVs >100 kb, of which the majority resided in 15q11.2. Based on the discordance of raw intensity signals a selection was made of 20 de novo CNVs for a qPCR validation experiments. Two out of 20 post-<span class="hlt">twinning</span> de novo CNVs were validated with qPCR in the same <span class="hlt">twin</span> pair. The 13-year-old MZ <span class="hlt">twin</span> pair that showed two discordances in CN in 15q11.2 in their buccal DNA did not show large phenotypic differences. From the remaining 18 putative de novo CNVs, 17 were deletions or duplications that were concordant within MZ <span class="hlt">twin</span> pairs. Concordance rates within <span class="hlt">twin</span> pairs of CNV calls with CN ? 2 were ~80%. Buccal epithelium-derived DNA showed a slightly but significantly higher concordance rate, and blood-derived DNA showed significantly more concordant CNVs per <span class="hlt">twin</span> pair. The gene-enrichment analyses on concordant CNVs showed no significant associations between CNVs overlapping with genes involved in neuronal processes and TP or AP after accounting for the source of DNA. PMID:25578775</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2014PhyC..507...41M','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2014PhyC..507...41M"><span id="translatedtitle"><span class="hlt">Twin</span> boundary energy and characterization of charge redistribution near the <span class="hlt">twin</span> boundaries of cupperate superconductors</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Mohammadi, Mahnaz; Khoshnevisan, Bahram; Javad Hashemifar, S.</p> <p>2014-12-01</p> <p>Ab-initio calculations under general gradient approximation have been employed for the first time to find out <span class="hlt">twin</span> boundary energy, ?, in twined YBCO systems. Despite a vast discrepancy in reported experimental values, our results show that the ? value falls in the range of 40-85 mJ/m2. On the other hand, functional form of ? versus inserted strains shows that the mean value for the <span class="hlt">twin</span> width lamella would tend to approach zero as the strain goes to zero. We have also investigated the local charge transfer and the modification of the electronic states of the basal and <span class="hlt">twin</span> planes in YBCO, because the charge redistribution at interfaces can modify transport across the grains considerably and determine the applicability of high-Tc superconductors in the electronic applications. The total density of electronic states at the Fermi level for the twined system is enhanced in comparison with the untwined one. Our results explain the influence of <span class="hlt">twin</span> boundaries in superconductive properties of YBCO, in experimental situations.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://falk.syr.edu/Documents/2014/FalkCollegeMagazine2013.pdf','EPRINT'); return false;" href="http://falk.syr.edu/Documents/2014/FalkCollegeMagazine2013.pdf"><span id="translatedtitle">FalkCollege Building <span class="hlt">healthy</span></span></a></p> <p><a target="_blank" href="http://www.osti.gov/eprints/">E-print Network</a></p> <p>McConnell, Terry</p> <p></p> <p>FalkCollege Building <span class="hlt">healthy</span> communities Making a positive impact on local, global levels MAGAZINE' classrooms 10 Building <span class="hlt">healthy</span> communities How the Falk College is making positive impacts locally, globally, T his edition's theme, "Building <span class="hlt">Healthy</span> Communities," fittingly describes what goes on in the Falk</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li class="active"><span>25</span></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_25 --> <center> <div class="footer-extlink text-muted"><small>Some links on this page may take you to non-federal websites. 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