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Sample records for heart-lung machine

  1. 21 CFR 870.4220 - Cardiopulmonary bypass heart-lung machine console.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Cardiopulmonary bypass heart-lung machine console... Cardiopulmonary bypass heart-lung machine console. (a) Identification. A cardiopulmonary bypass heart-lung machine... heart-lung machine. The console is designed to interface with the basic units used in a gas...

  2. 21 CFR 870.4220 - Cardiopulmonary bypass heart-lung machine console.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Cardiopulmonary bypass heart-lung machine console... Cardiopulmonary bypass heart-lung machine console. (a) Identification. A cardiopulmonary bypass heart-lung machine... heart-lung machine. The console is designed to interface with the basic units used in a gas...

  3. 21 CFR 870.4220 - Cardiopulmonary bypass heart-lung machine console.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Cardiopulmonary bypass heart-lung machine console... Cardiopulmonary bypass heart-lung machine console. (a) Identification. A cardiopulmonary bypass heart-lung machine... heart-lung machine. The console is designed to interface with the basic units used in a gas...

  4. 21 CFR 870.4220 - Cardiopulmonary bypass heart-lung machine console.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Cardiopulmonary bypass heart-lung machine console... Cardiopulmonary bypass heart-lung machine console. (a) Identification. A cardiopulmonary bypass heart-lung machine... heart-lung machine. The console is designed to interface with the basic units used in a gas...

  5. 21 CFR 870.4220 - Cardiopulmonary bypass heart-lung machine console.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Cardiopulmonary bypass heart-lung machine console... Cardiopulmonary bypass heart-lung machine console. (a) Identification. A cardiopulmonary bypass heart-lung machine... heart-lung machine. The console is designed to interface with the basic units used in a gas...

  6. Perfusion of isolated organs and the first heart-lung machine.

    PubMed

    Zimmer, H G

    2001-09-01

    In 1885, Max von Frey (1852-1932), while working in Carl Ludwig's Physiological Institute in Leipzig, Germany, designed an apparatus that had criteria characteristic of a heart-lung machine. With this device, he perfused the entire lower extremity of dogs, and took measurements of oxygen consumption, and carbon dioxide and lactate production. In 1935, another type of perfusion apparatus was constructed by Charles A Lindbergh (1902-1973). This device was the result of cooperation with Alexis Carrel (1873-1944) who was a pioneer of experimental organ transplantation. Using Lindbergh's pulsating device, organs such as thyroid, ovary, suprarenal gland, spleen, heart and kidney from fowls and cats were perfused with an oxygenated medium, and were maintained under sterile conditions. Beginning in 1934, John H Gibbon (1903-1973) developed and tested a heart-lung machine to institute cardiopulmonary bypass in cats during experimental occlusion of the pulmonary artery. In 1953, he performed the first successful open-heart operation in a patient using a heart-lung machine. This included elements that were similar to those used by von Frey - ie, the oxygenator and the pumps for continuous circulation of blood. A comparison of the three experimental devices revealed the following: the application for experimental purposes preceded clinical use; the development shifted from Europe to the United States, and was achieved by people who were not specialists; and the intention to build such a device was first purely scientific interest, but later shifted to the care for and treatment of patients with heart and circulatory defects by open-heart surgery. PMID:11586387

  7. The Aachen MiniHLM--a miniaturized heart-lung machine for neonates with an integrated rotary blood pump.

    PubMed

    Arens, Jutta; Schnoering, Heike; Pfennig, Michael; Mager, Ilona; Vázquez-Jiménez, Jaime F; Schmitz-Rode, Thomas; Steinseifer, Ulrich

    2010-09-01

    The operation of congenital heart defects in neonates often requires the use of heart-lung machines (HLMs) to provide perfusion and oxygenation. This is prevalently followed by serious complications inter alia caused by hemodilution and extrinsic blood contact surfaces. Thus, one goal of developing a HLM for neonates is the reduction of priming volume and contact surface. The currently available systems offer reasonable priming volumes for oxygenators, reservoirs, etc. However, the necessary tubing system contains the highest volumes within the whole system. This is due to the use of roller pumps; hence, the resulting placement of the complete HLM is between 1 and 2 m away from the operating table due to connective tubing between the components. Therefore, we pursued a novel approach for a miniaturized HLM (MiniHLM) by integrating all major system components in one single device. In particular, the MiniHLM is a HLM with the rotary blood pump centrically integrated into the oxygenator and a heat exchanger integrated into the cardiotomy reservoir which is directly connected to the pump inlet. Thus, tubing is only necessary between the patient and MiniHLM. A total priming volume of 102 mL (including arterial filter and a/v line) could be achieved. To validate the overall concept and the specific design we conducted several in vitro and in vivo test series. All tests confirm the novel concept of the MiniHLM. Its low priming volume and blood contact surface may significantly reduce known complications related to cardiopulmonary bypass in neonates (e.g., inflammatory reaction and capillary leak syndrome). PMID:20883389

  8. Heart-lung transplant - series (image)

    MedlinePlus

    A combined heart-lung transplant may be recommended for patients who have both cardiac and lung disease. The most common reasons for a combined heart-lung transplant are pulmonary hypertension, cystic fibrosis, ...

  9. Heart-lung transplant - slideshow

    MedlinePlus

    ... this page: //medlineplus.gov/ency/presentations/100147.htm Heart-lung transplant - series To use the sharing features on this ... A.M. Editorial team. Related MedlinePlus Health Topics Heart Transplantation Lung Transplantation A.D.A.M., Inc. is ...

  10. Beginnings of open-heart surgery in Gdansk – double role of the Pemco heart-lung machine and new facts about Dutch-Polish cooperation

    PubMed Central

    2016-01-01

    The first open-heart surgery in Gdansk took place in 1975. It was possible thanks to the gift of a Pemco extracorporeal circulation machine from the Netherlands to the Surgery Institute of the Medical Academy of Gdansk. The article presents additional, unpublished informations which enable a new interpretation of the previously known facts. PMID:27516801

  11. 76 FR 21387 - National Heart, Lung, and Blood Institute;

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-15

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... privacy. Name of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; BABYHUG Data.../DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7182, Bethesda, MD...

  12. 76 FR 30371 - National Heart, Lung, and Blood Institute; Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-25

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Meetings Notice... personal privacy. Name of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; HIV..., Scientific Review Officer, Office of Scientific Review/DERA, National Heart, Lung, and Blood Institute,...

  13. Heart-Lung Interactions in Aerospace Medicine

    NASA Technical Reports Server (NTRS)

    Guy, Harold J. B.; Prisk, Gordon Kim

    1991-01-01

    Few of the heart-lung interactions that are discussed have been studied in any detail in the aerospace environment, but is seems that many such interactions must occur in the setting of altered accelerative loadings and pressure breathing. That few investigations are in progress suggests that clinical and academic laboratory investigators and aerospace organizations are further apart than during the pioneering work on pressure breathing and acceleration tolerance in the 1940s. The purpose is to reintroduce some of the perennial problems of aviation physiology as well as some newer aerospace concerns that may be of interest. Many possible heart-lung interactions are pondered, by necessity often drawing on data from within the aviation field, collected before the modern understanding of these interactions developed, or on recent laboratory data that may not be strictly applicable. In the field of zero-gravity effects, speculation inevitably outruns the sparse available data.

  14. 76 FR 30372 - National Heart, Lung, and Blood Institute; Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-25

    ... personal privacy. Name of Committee: Heart, Lung, and Blood Initial Review Group; Clinical Trials Review... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Meeting Notice..., and Blood Institute, 6701 Rockledge Drive, Room 7190, Bethesda, MD 20892-7924, 301-435-2222,...

  15. 75 FR 29356 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-25

    ... of Committee: Heart, Lung, and Blood Initial Review Group; Heart, Lung, and Blood Program Project... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7208, Bethesda, MD 20892-7924,...

  16. 76 FR 10912 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-28

    ... of Committee: Heart, Lung, and Blood Initial Review Group, Heart, Lung, and Blood Program Project... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... Heart, Lung, and Blood Institute, National Institutes of Health, 6701 Rockledge Drive, Room...

  17. 77 FR 30541 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-23

    ... of Committee: Heart, Lung, and Blood Initial Review Group; Heart, Lung, and Blood Program Project... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed.../DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7208, Bethesda, MD...

  18. 76 FR 28996 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-19

    ... of Committee: Heart, Lung, and Blood Initial Review Group, Heart, Lung, and Blood Program Project... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed..., National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7208, Bethesda, MD 20892-7924,...

  19. 75 FR 68368 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-05

    ... of Committee: Heart, Lung, and Blood Initial Review Group, Heart, Lung, and Blood Program Project... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7208, Bethesda, MD 20892-7924,...

  20. 77 FR 12599 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-01

    ... of Committee: Heart, Lung, and Blood Initial Review Group, Heart, Lung, and Blood Program Project... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed.../DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7208, Bethesda, MD...

  1. 77 FR 66854 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-07

    ... of Committee: Heart, Lung, and Blood Initial Review Group; Heart, Lung, and Blood Program Project... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... Scientific Review/DERA, National Heart, Lung, and Blood Institute, National Institutes of Health,...

  2. 78 FR 13880 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-01

    ... of Committee: Heart, Lung, and Blood Initial Review Group, Heart, Lung, and Blood Program Project... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... Review/DERA, National Heart, Lung, and Blood Institute, National Institutes of Health, 6701...

  3. 75 FR 9912 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-04

    ... of Committee: Heart, Lung, and Blood Initial Review Group; Heart, Lung, and Blood Program Project... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7208, Bethesda, MD 20892-7924,...

  4. Cardiopulmonary bypass: development of John Gibbon's heart-lung machine

    PubMed Central

    Passaroni, Andréia Cristina; Silva, Marcos Augusto de Moraes; Yoshida, Winston Bonetti

    2015-01-01

    Objective To provide a brief review of the development of cardiopulmonary bypass. Methods A review of the literature on the development of extracorporeal circulation techniques, their essential role in cardiovascular surgery, and the complications associated with their use, including hemolysis and inflammation. Results The advancement of extracorporeal circulation techniques has played an essential role in minimizing the complications of cardiopulmonary bypass, which can range from various degrees of tissue injury to multiple organ dysfunction syndrome. Investigators have long researched the ways in which cardiopulmonary bypass may insult the human body. Potential solutions arose and laid the groundwork for development of safer postoperative care strategies. Conclusion Steady progress has been made in cardiopulmonary bypass in the decades since it was first conceived of by Gibbon. Despite the constant evolution of cardiopulmonary bypass techniques and attempts to minimize their complications, it is still essential that clinicians respect the particularities of each patient's physiological function. PMID:26107456

  5. 75 FR 51828 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-23

    ... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Heart Failure... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7182, Bethesda, MD 20892-7924,...

  6. 75 FR 52957 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-30

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel, Resource for..., National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7178, Bethesda, MD 20892-7924,...

  7. 76 FR 1441 - National Heart, Lung, and Blood Institute; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-10

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of....), notice is hereby given of a meeting of the National Heart, Lung, and Blood Advisory Council. The meeting... clearly unwarranted invasion of personal privacy. Name of Committee: National Heart, Lung, and...

  8. 76 FR 8752 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-15

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Short-Term Research..., Review Branch/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7182,...

  9. 76 FR 14674 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-17

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Emergency Medicine..., National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7196, Bethesda, MD 20892-7924,...

  10. 78 FR 37836 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-24

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; NHLBI Conference... Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7185, Bethesda,...

  11. 75 FR 65498 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-25

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel, Career Enhancement... Officer, Review Branch/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room...

  12. 77 FR 2739 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-19

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Genetics of Heart... Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7200,...

  13. 75 FR 42100 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-20

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed....), notice is hereby given of a meeting of the National Heart, Lung, and Blood Advisory Council. The meeting... clearly unwarranted invasion of personal privacy: Name of Committee: National Heart, Lung, and...

  14. 78 FR 37233 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-20

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Mechanisms of HIV..., Office of Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive,...

  15. 77 FR 22580 - National Heart, Lung, and Blood Institute; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-16

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of....), notice is hereby given of a meeting of the National Heart, Lung, and Blood Advisory Council. The meeting... clearly unwarranted invasion of personal privacy. Name of Committee: National Heart, Lung, and...

  16. 76 FR 42718 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-19

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel, Consortium of Lung... Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7184, Bethesda, MD 20892-7924,...

  17. 77 FR 12602 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-01

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... privacy. Name of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel... Creazzo, Ph.D., Scientific Review Officer, Office of Scientific Review/DERA, National Heart, Lung,...

  18. 77 FR 1702 - National Heart, Lung, and Blood Institute; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-11

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of....), notice is hereby given of a meeting of the National Heart, Lung, and Blood Advisory Council. The meeting... clearly unwarranted invasion of personal privacy. Name of Committee: National Heart, Lung, and...

  19. 76 FR 78285 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-16

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel,SBIR Topic 56 Blood..., DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7198, Bethesda, MD...

  20. 76 FR 1186 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-07

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel Multiplexed Assay... Review Officer. Name of Committee: National Heart, Lung, and Blood Institute Special Emphasis...

  1. 77 FR 75180 - National Heart, Lung, and Blood Institute; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-19

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of....), notice is hereby given of a meeting of the National Heart, Lung, and Blood Advisory Council. The meeting... clearly unwarranted invasion of personal privacy. Name of Committee: National Heart, Lung, and...

  2. 75 FR 80831 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-23

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... privacy. Name of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel... Review Officer, Office of Scientific Review/DERA, National Heart, Lung, and Blood Institute,...

  3. 78 FR 66031 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-04

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... privacy. Name of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Novel Tools...., Scientific Review Officer, Office of Scientific Review/DERA, National Heart, Lung, and Blood Institute,...

  4. 76 FR 57062 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-15

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel, Translational... Review Officer, Office of Scientific Review/DERA, National Heart, Lung, and Blood Institute,...

  5. 77 FR 59939 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-01

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... privacy. Name of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; SBIR Phase... Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7180, Bethesda,...

  6. 77 FR 43343 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-24

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Jackson Heart Study RFA Review..., National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7180, Bethesda, MD 20892-7924,...

  7. 78 FR 52937 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-27

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... privacy. Name of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Wireless... Review Officer, Office of Scientific Review/DERA, National, Heart, Lung, and Blood Institute,...

  8. 78 FR 12073 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-21

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel Clinical Trials SEP... Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7188, Bethesda,...

  9. 78 FR 58321 - National Heart, Lung, and Blood Institute; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-23

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of....), notice is hereby given of a meeting of the National Heart, Lung, and Blood Advisory Council. The meeting... clearly unwarranted invasion of personal privacy. Name of Committee: National Heart, Lung, and...

  10. 77 FR 13134 - National Heart, Lung, and Blood Institute: Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-05

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute: Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Sickle Cell Disease... Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7198,...

  11. 77 FR 69869 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-21

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed.... ] Name of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel Sleep Research..., Office of Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive,...

  12. 78 FR 12767 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-25

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Translational... Scientific Review/DERA, National, Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7182,...

  13. 78 FR 12766 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-25

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; SBIR Topic 80... Sunnarborg, Ph.D., Scientific Review Officer, Office of Scientific Review/DERA, National, Heart, Lung,...

  14. 77 FR 30542 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-23

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel, NHLBI Career... Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Rm. 7202,...

  15. 78 FR 60299 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-01

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Mentored Career... Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7186, Bethesda, MD 20892-7924,...

  16. 77 FR 59935 - National Heart, Lung, And Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-01

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, And Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Engine for Fast... Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7180,...

  17. 77 FR 10538 - National Heart, Lung, and Blood Institute Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-22

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Cardiothoracic... Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7179, Bethesda,...

  18. 77 FR 60705 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-04

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Minority... Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7179, Bethesda,...

  19. 78 FR 7792 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-04

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; SBIR Contract... Review Officer, Office of Scientific Review/DERA, National Heart, Lung, and Blood Institute,...

  20. 75 FR 71450 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-23

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel Institutional National.../DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7176, Bethesda, MD...

  1. 76 FR 2128 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-12

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel, Loan Repayment... Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7180, Bethesda, MD 20892-7924....

  2. 78 FR 60299 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-01

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel, NHLBI Program Project... of Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room...

  3. 78 FR 29375 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-20

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; NHLBI Resource...., Scientific Review Officer, Office of Scientific Review/DERA, National Heart, Lung, and Blood Institute,...

  4. 77 FR 6809 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-09

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... privacy. Name of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Technologies... Officer, Office of Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge...

  5. 75 FR 66772 - National Heart, Lung, and Blood Institute; Notice of Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-29

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of... Center on Sleep Disorders Research, Division of Lung Diseases, National Heart, Lung, and Blood Institute... Research, Division of Lung Diseases, National Heart, Lung, and Blood Institute, National Institutes...

  6. 76 FR 11253 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-01

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; MAPGen and MAPGenKB..., National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7184, Bethesda, MD 20892-7924,...

  7. 75 FR 66771 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-29

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed.... ] Name of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Centers for..., Scientific Review Officer, Office of Scientific Review, National Heart, Lung, and Blood Institute,...

  8. 77 FR 24728 - National Heart, Lung, and Blood Institute Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-25

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute Notice of Closed... privacy. Name of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Sudden..., Office of Scientific Review/DERA, National, Heart, Lung, and Blood Institute, 6701 Rockledge Drive,...

  9. 78 FR 66025 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-04

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; NHLBI Conference... Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7185, Bethesda,...

  10. 76 FR 25701 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-05

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... privacy. Name of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel, Heart Pumps... Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7179,...

  11. 77 FR 1703 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-11

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel Program Project Grant... Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7206,...

  12. 76 FR 12362 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-07

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Translational... of Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room...

  13. 77 FR 36565 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-19

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; NHLBI Conference..., National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7200, Bethesda, MD 20892,...

  14. 77 FR 2738 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-19

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Wireless Physiologic... Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7204,...

  15. 78 FR 63994 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-25

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel, Genetic Basis of... Officer, Office of Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge...

  16. 78 FR 42529 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-16

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel Resource related... Review Officer, Office of Scientific Review/DERA, National, Heart, Lung, and Blood Institute,...

  17. 78 FR 7791 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-04

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Resource related..., Ph.D., Scientific Review Officer, Office of Scientific Review/DERA, National Heart, Lung, and...

  18. 77 FR 69639 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-20

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... privacy. Name of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; PETAL... of Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room...

  19. 78 FR 42967 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-18

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Pediatric Pulmonary... Sunnarborg, Ph.D., Scientific Review Officer, Office of Scientific Review/DERA, National Heart, Lung,...

  20. 77 FR 9670 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-17

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Novel Technologies..., National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7196, Bethesda, MD 20892, 301-...

  1. 78 FR 2680 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-14

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; K23, K24, K25 Research Career.../DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7196, Bethesda, MD...

  2. 77 FR 18252 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-27

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; NHLBI Conference... Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7179, Bethesda,...

  3. 77 FR 71429 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-30

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel Jackson Heart Study..., National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7196, Bethesda, MD 20892-7924,...

  4. 77 FR 33473 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-06

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel HIV Lung Disease and... Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7184, Bethesda, MD 20892-7924,...

  5. 77 FR 71428 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-30

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; NHLBI T32 Training..., National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7189, Bethesda, MD 20892,...

  6. 78 FR 27411 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-10

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; NHLBI Program Project... Review Officer, Office of Scientific Review/DERA, National Heart, Lung, and Blood Institute,...

  7. 78 FR 22272 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-15

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... privacy. Name of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; NHLBI Loan... Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7192,...

  8. 77 FR 31863 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-30

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Understanding..., Office of Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive,...

  9. 78 FR 42970 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-18

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Short-term Training... Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7196, Bethesda,...

  10. 78 FR 7795 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-04

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Review of a resource....D., Scientific Review Officer, Office of Scientific Review/DERA, National Heart, Lung, and...

  11. 77 FR 38849 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-29

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... privacy. Name of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Long Term..., Office of Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive,...

  12. 78 FR 31952 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-28

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; NHLBI Resource... Review Officer, Office of Scientific Review/DERA, National Heart, Lung, and Blood Institute,...

  13. 78 FR 57866 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-20

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Sample Biorepository and... Review Officer, Office of Scientific Review/DERA, National Heart, Lung, and Blood Institute,...

  14. 75 FR 48979 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-12

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Ischemia Trials. Date...). Contact Person: Youngsuk Oh, PhD, Scientific Review Officer, Review Branch/DERA, National Heart, Lung,...

  15. 77 FR 61421 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-09

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... privacy. Name of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel... Webb, Ph.D., Scientific Review Officer, Office of Scientific Review/DERA, National Heart, Lung,...

  16. 76 FR 58523 - National Heart, Lung, and Blood Institute; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-21

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of....), notice is hereby given of a meeting of the National Heart, Lung, and Blood Advisory Council. The meeting... of Committee: National Heart, Lung, and Blood Advisory Council. ] Date: October 18, 2011. Open: 8...

  17. 78 FR 11657 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-19

    ... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Allogeneic Transplant... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... Officer, Office of Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge...

  18. 76 FR 3641 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-20

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel, Program Project in... Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7206, Bethesda,...

  19. 78 FR 10185 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-13

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... privacy. Name of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; SBIR Topic... Sunnarborg, Ph.D., Scientific Review Officer, Office of Scientific Review/DERA, National, Heart, Lung,...

  20. 77 FR 59200 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-26

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel Mentored Career..., National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7192, Bethesda, MD 20892,...

  1. 78 FR 69431 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-19

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; PETAL Clinical... Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7178,...

  2. 77 FR 65568 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-29

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Regulation of Blood... Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7196,...

  3. 77 FR 57099 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-17

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; NHLBI Resource.... Scientific Review Officer, Office of Scientific Review/DERA, National Heart, Lung, and Blood Institute,...

  4. 77 FR 63844 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-17

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Bio-Specimen... of Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room...

  5. 78 FR 54259 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-03

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; K23, K24, K25..., National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7196, Bethesda, MD 20892,...

  6. 77 FR 43098 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-23

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Asthma in Older.../DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7190, Bethesda, MD...

  7. 75 FR 56552 - National Heart, Lung, and Blood Institute; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-16

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of....), notice is hereby given of a meeting of the National Heart, Lung, and Blood Advisory Council. The meeting... clearly unwarranted invasion of personal privacy. Name of Committee: National Heart, Lung, and...

  8. 78 FR 19725 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-02

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Training in Lung... Joyce, Ph.D., Scientific Review Officer, Office of Scientific Review/DERA, National Heart, Lung,...

  9. 76 FR 58025 - National Heart, Lung and Blood Institute Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-19

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung and Blood Institute Notice of Closed... privacy. Name of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Gene Therapy... of Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room...

  10. 76 FR 45843 - National Heart, Lung, and Blood Institute Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-01

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute Notice of Closed....), notice is hereby given of a meeting of the National Heart, Lung, and Blood Advisory Council. The meeting... clearly unwarranted invasion of personal privacy. Name of Committee: National Heart, Lung, and...

  11. 77 FR 14533 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-12

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel Basic Research in..., National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7204, Bethesda, MD 20892-7924,...

  12. 77 FR 6571 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-08

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; NHLBI Minority.../DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7196, Bethesda, MD...

  13. 77 FR 59200 - National Heart, Lung, and Blood Institute; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-26

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of....), notice is hereby given of a meeting of the National Heart, Lung, and Blood Advisory Council. The meeting... clearly unwarranted invasion of personal privacy. Name of Committee: National Heart, Lung, and...

  14. 78 FR 14563 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-06

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; NHLBI K Career... Officer, Office of Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge...

  15. 77 FR 39716 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-05

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel Resource Related... Officer, Office of Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge...

  16. 76 FR 27068 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-10

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel, SBIR Contract Review..., National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7184, Bethesda, MD 20892-7924....

  17. 75 FR 54642 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-08

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... privacy. Name of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Maintenance... Officer, Review Branch/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room...

  18. 77 FR 14024 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-08

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... privacy. Name of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Development... Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7186,...

  19. 75 FR 61507 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-05

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; NHLBI Research... Branch, DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7190, Bethesda,...

  20. 75 FR 31796 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-04

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel, Coordination Core for... Webb, PhD, Scientific Review Officer, Review Branch/DERA, National Heart, Lung, and Blood...

  1. 77 FR 67827 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-14

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Ancillary Studies..., National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7178, Bethesda, MD 20892-7924,...

  2. 77 FR 24973 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-26

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; The Kidney in.../DERA, National Heart, Lung, and Blood Institute, National Institutes of Health, 6701 Rockledge...

  3. 77 FR 76058 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-26

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... privacy. Name of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Hispanic... Officer, Office of Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge...

  4. 77 FR 43099 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-23

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Research... Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7186, Bethesda, MD 20892-7924,...

  5. 76 FR 47218 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-04

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel, Training Grant Review... Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7176, Bethesda, MD 20892-7924,...

  6. 78 FR 69431 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-19

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Research Career... Officer, Office of Review Branch/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge...

  7. 78 FR 20670 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-05

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Hypoxia and... Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7206,...

  8. 76 FR 23827 - National Heart, Lung, and Blood Institute; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-28

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of....), notice is hereby given of a meeting of the National Heart, Lung, and Blood Advisory Council. ] The... clearly unwarranted invasion of personal privacy. Name of Committee: National Heart, Lung, and...

  9. 78 FR 50427 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-19

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed....), notice is hereby given of a meeting of the National Heart, Lung, and Blood Advisory Council. The meeting... clearly unwarranted invasion of personal privacy. Name of Committee: National Heart, Lung, and...

  10. 77 FR 48526 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-14

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute, Special Emphasis Panel, Biostatistics..., National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7190, Bethesda, MD 20892-7924,...

  11. 76 FR 55077 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-06

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Translational..., Office of Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive,...

  12. 78 FR 69432 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-19

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Clinical Trials... Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7188,...

  13. 75 FR 8085 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-23

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Research Program... Branch/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7178, Bethesda,...

  14. 77 FR 12856 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-02

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel, NHLBI Cardiovascular... Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7196,...

  15. 77 FR 76056 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-26

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; NHLBI CARDIA Echo... Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7184,...

  16. 78 FR 28229 - National Heart, Lung, and Blood Institute; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-14

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of....), notice is hereby given of a meeting of the National Heart, Lung, and Blood Advisory Council. The meeting... of Committee: National Heart, Lung, and Blood Advisory Council. ] Date: June 19, 2013. Open: 8:00...

  17. 75 FR 56548 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-16

    ... of Committee: Heart, Lung, and Blood Initial Review Group Clinical Trials Review Committee. Date... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... Person: Keary A Cope, PhD, Scientific Review Officer, Review Branch/DERA, National Heart, Lung, and...

  18. 77 FR 59939 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-01

    ... of Committee: Heart, Lung, and Blood Initial Review Group; Clinical Trials Review Committee. Date... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed...., Scientific Review Officer, Review Branch/DERA, National Heart, Lung, and Blood Institute, 6701...

  19. 78 FR 67370 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-12

    ... of Committee: Heart, Lung, and Blood Initial Review Group; Heart, Lung, and Blood Program Project..., Lung, and Blood Initial Review Group; NHLBI Institutional Training Mechanism Review Committee. Date... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of...

  20. 78 FR 32408 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-30

    ... of Committee: Heart, Lung, and Blood Initial Review Group NHLBI Institutional Training Mechanism... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7196, Bethesda,...

  1. 76 FR 5596 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-01

    ... of Committee: Heart, Lung, and Blood Initial Review Group, Clinical Trials Review Committee. Date... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed...: Keary A Cope, PhD, Scientific Review Officer, Review Branch/DERA, National Heart, Lung, and...

  2. 75 FR 4829 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-29

    ... of Committee: Heart, Lung, and Blood Initial Review Group, Clinical Trials Review Committee. Date... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed...: Keary A Cope, PhD, Scientific Review Officer, Review Branch/DERA, National Heart, Lung, and...

  3. 75 FR 29353 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-25

    ... of Committee: Heart, Lung, and Blood Initial Review Group, Clinical Trials Review Committee. Date... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... Person: Keary A Cope, PhD, Scientific Review Officer, Review Branch/DERA, National Heart, Lung, and...

  4. 78 FR 33428 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-04

    ... of Committee: Heart, Lung, and Blood Initial Review Group; Clinical Trials Review Committee. Date... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed...., Scientific Review Officer, Office of Scientific Review/DERA, National Heart, Lung, and Blood Institute,...

  5. 76 FR 70462 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-14

    ... of Committee: Heart, Lung, and Blood Initial Review Group; Heart, Lung, and Blood Program Project... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed..., and Blood Institute, 6701 Rockledge Drive, Room 7208, Bethesda, MD 20892-7924, (301) 435-0303,...

  6. 77 FR 31863 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-30

    ... of Committee: Heart, Lung, and Blood Initial Review Group; NHLBI Institutional Training Mechanism... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7196, Bethesda,...

  7. 76 FR 71580 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-18

    ... of Committee: Heart, Lung, and Blood Initial Review Group, NHLBI Institutional Training Mechanism... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7196, Bethesda,...

  8. 78 FR 30319 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-22

    ...-0287, Pintuccig@nhlbi.nih.gov . Name of Committee: Heart, Lung, and Blood Initial Review Group; Heart... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Pathway...

  9. 76 FR 64360 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-18

    ... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel, Virtual Reality... Blood Institute Special Emphasis Panel, Virtual Reality Technologies for Research and Education...

  10. 76 FR 16631 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-24

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... constitute a clearly unwarranted invasion of personal privacy. Name of Committee: National Heart, Lung, and....) Contact Person: Keith A. Mintzer, PhD, Scientific Review Officer, Review Branch/DERA, National Heart,...

  11. 75 FR 13768 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-23

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel, Conference Grants....) Contact Person: Robert T. Su, Ph.D., Scientific Review Officer, Review Branch/DERA, National Heart,...

  12. 75 FR 9912 - National Heart, Lung, and Blood Institute; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-04

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of..., National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Suite 9030, Bethesda, MD 20892, 301-435... Center for Sleep Disorders Research; 93.837, Heart and Vascular Diseases Research; 93.838, Lung...

  13. 78 FR 63995 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-25

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel Intermittent Hypoxia...: William J Johnson, Ph.D., Scientific Review Officer, Office of Scientific Review/DERA, National...

  14. 78 FR 7792 - National Heart, Lung, and Blood Institute; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-04

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of... Sleep Disorders Research, Division of Lung Diseases, National Heart, Lung, and Blood Institute, National..., Heart and Vascular Diseases Research; 93.838, Lung Diseases Research; 93.839, Blood Diseases...

  15. 76 FR 57066 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-15

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... and projects conducted by the National Heart, Lung, and Blood Institute, including consideration of...; 93.837, Heart and Vascular Diseases Research; 93.838, Lung Diseases Research; 93.839, Blood...

  16. 76 FR 40923 - National Heart, Lung, and Blood Institute Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-12

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Reducing Emergency..., Heart and Vascular Diseases Research; 93.838, Lung Diseases Research; 93.839, Blood Diseases...

  17. 76 FR 57061 - National Heart, Lung, and Blood Institute; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-15

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of..., National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Suite 9030, Bethesda, MD 20892, 301-435... Center for Sleep Disorders Research; 93.837, Heart and Vascular Diseases Research; 93.838, Lung...

  18. 76 FR 19106 - National Heart, Lung, and Blood Institute; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-06

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of... Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Suite 9030, Bethesda, MD 20892, 301-435-0080... Center for Sleep Disorders Research; 93.837, Heart and Vascular Diseases Research; 93.838, Lung...

  19. 76 FR 11254 - National Heart, Lung, and Blood Institute; Amended Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-01

    ... Register on February 15, 2011, FR 2011-3373. The meeting was originally advertised for March 9-10, 2011... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Amended Notice of Meeting Notice is hereby given of a change in the meeting of the National Heart, Lung, and...

  20. 77 FR 58402 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-20

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... programs and projects conducted by the National Heart, Lung, and Blood Institute, including consideration... Disorders Research; 93.837, Heart and Vascular Diseases Research; 93.838, Lung Diseases Research;...

  1. 75 FR 5090 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-01

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel, Science Moving.... Contact Person: William J Johnson, PhD, Scientific Review Officer, Review Branch/DERA, National...

  2. 78 FR 22892 - National Heart, Lung, and Blood Institute; Amended Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-17

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Amended Notice of Meeting Notice is hereby given of a change in the meeting of the National Heart, Lung, and...

  3. 77 FR 66853 - National Heart, Lung, and Blood Institute; Amended Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-07

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Amended Notice of Meeting Notice is hereby given of a change in the meeting of the National Heart, Lung, and Blood Advisory Council, October 30, 2012, 08:00 a.m....

  4. 76 FR 12123 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-04

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Blood & Marrow Transplant Network Review Meeting. Date: March 28-29, 2011. Time: 8 a.m. to 5 p.m. Agenda: To review...

  5. 76 FR 15330 - National Heart, Lung, and Blood Institute; Amended Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-21

    ... on January 11, 2011, FR 2011-583. This meeting was originally scheduled for February 1, 2011 but will... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Amended Notice of Meeting Notice is hereby given of a change in the meeting of the National Heart, Lung, and...

  6. 75 FR 76478 - National Heart, Lung, and Blood Institute; Amended Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-08

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Amended Notice of Meeting Notice is hereby given of a change in the meeting of the National Heart, Lung, and...

  7. 78 FR 69430 - National Heart, Lung, and Blood Institute Amended; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-19

    ... published in the Federal Register on September 20, 2013, 78 FR 57866. The notice is amended to change the... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute Amended; Notice of Meeting Notice is hereby given of a change in the meeting of the National Heart, Lung, and...

  8. 75 FR 61508 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-05

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... and projects conducted by the National Heart, Lung, and Blood Institute, including consideration of....837, Heart and Vascular Diseases Research; 93.838, Lung Diseases Research; 93.839, Blood Diseases...

  9. 78 FR 57168 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-17

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... and projects conducted by the National Heart, Lung, and Blood Institute, including consideration of....837, Heart and Vascular Diseases Research; 93.838, Lung Diseases Research; 93.839, Blood Diseases...

  10. 77 FR 28612 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-15

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee National Heart, Lung, and Blood Institute Special Emphasis Panel; Early Cystic Fibrosis..., Lung, and Blood Institute, 6701 Rockledge Drive, Room 7189, Bethesda, MD 20892,...

  11. 76 FR 29254 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-20

    ... of Committee: Heart, Lung, and Blood Initial Review Group; NHLBI Institutional Training Mechanism... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed..., Lung, and Blood Institute, 6701 Rockledge Drive, Room 7196, Bethesda, MD 20892-7924,...

  12. 76 FR 62422 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-07

    ... of Committee: Heart, Lung, and Blood Initial Review Group, Clinical Trials Review Committee. Date... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... Blood Institute, 6701 Rockledge Drive, Room 7190, Bethesda, MD 20892-7924, 301-435-2222,...

  13. 75 FR 29356 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-25

    ... of Committee: Heart, Lung, and Blood Initial Review Group, NHLBI Institutional Training Mechanism... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed..., Lung, and Blood Institute, 6701 Rockledge Drive, Room 7196, Bethesda, MD 20892-7924....

  14. 78 FR 9708 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-11

    ... of Committee: Heart, Lung, and Blood Initial Review Group Clinical Trials Review Committee. Date... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... Blood Institute, 6701 Rockledge Drive, Room 7190, Bethesda, MD 20892-7924, 301-435-2222,...

  15. 78 FR 60299 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-01

    ... of Committee: Heart, Lung, and Blood Initial Review Group; Clinical Trials Review Committee. Date... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed..., Lung, and Blood Institute, 6701 Rockledge Drive, Room 7190, Bethesda, MD 20892-7924,...

  16. 77 FR 6571 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-08

    ... of Committee: Heart, Lung, and Blood Initial Review Group Clinical Trials Review Committee Date... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... Blood Institute, 6701 Rockledge Drive, Room 7190, Bethesda, MD 20892-7924, (301) 435-2222,...

  17. 77 FR 32651 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-01

    ... privacy. Name of Committee: Heart, Lung, and Blood Initial Review Group, Clinical Trials Review Committee... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... Blood Institute, 6701 Rockledge Drive, Room 7190, Bethesda, MD 20892-7924, 301-435-2222,...

  18. 75 FR 70273 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-17

    ... of Committee: Heart, Lung, and Blood Initial Review Group, NHLBI Institutional Training Mechanism... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed..., Lung, and Blood Institute, 6701 Rockledge Drive, Room 7196, Bethesda, MD 20892-7924....

  19. 77 FR 69870 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-21

    ... of Committee: Heart, Lung, and Blood Initial Review Group; NHLBI Institutional Training Mechanism... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed..., and Blood Institute, 6701 Rockledge Drive, Room 7196, Bethesda, MD 20892-7924, 301-435-0288,...

  20. 78 FR 77477 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-23

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... privacy. Name of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Small Business Development of New Methods for Mitral Valve Repair. Date: January 10, 2014. Time: 2:00 p.m. to...

  1. 77 FR 16843 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-22

    .... Contact Person: Tony L. Creazzo, Ph.D., Scientific Review Officer, Office of Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7180, Bethesda, MD 20892-7924, 301... Officer, Review Branch/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room...

  2. 76 FR 70154 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-10

    ..., National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7184, Bethesda, MD 20892-7924. (301..., Review Branch/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7196, Bethesda... Regency Crystal City, 2799 Jefferson Davis Highway, Arlington, VA 22202. Contact Person: Tony L...

  3. 75 FR 34461 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-17

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel, Effectiveness Research on Smoking Cessation in Hospitalized Patients. Date: June 22-23, 2010. Time: 6 p.m. to 5...

  4. 75 FR 50771 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-17

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; NHLBI...

  5. Successful extended hypothermic cardiopulmonary preservation for heart-lung transplantation.

    PubMed

    Bando, K; Teramoto, S; Tago, M; Teraoka, H; Seno, S; Senoo, Y

    1989-07-01

    The inability to obtain sufficiently extended hypothermic organ preservation is a major restriction on clinical heart-lung transplantation. We used core cooling, nonrecirculating retrograde heart perfusion, and lung immersion with liposomal recombinant human superoxide dismutase in an attempt to provide effective 12-hour cardiopulmonary preservation. Donor dogs supported by cardiopulmonary bypass were rapidly cooled to 15 degrees C with cardioplegic arrest, and heterotopic heart and unilateral left lung transplantations were performed. In control dogs (n = 7), hearts and lungs, harvested after core cooling and cardioplegic arrest, were transplanted with a total mean ischemic time of 88 +/- 5 minutes. In group II (n = 7), heart-lung blocks were similarly excised but preserved at 4 degrees C for 12 hours (756 +/- 30 minutes) and then transplanted. During preservation, the lungs were immersed in hyperosmolar extracellular solution. For the heart, retrograde coronary sinus perfusion was performed with intracellular solution containing perfluorochemicals at a temperature of 4 degrees C and a rate of 30 ml/hr for 12 hours. In group III (n = 7), donor organs were similarly excised and preserved for 12 hours (726 +/- 39 minutes), except that liposomal recombinant human superoxide dismutase was administered during harvest, preservation, and reperfusion. Myocardial function, assessed by the ratio of end-systolic pressure to end-systolic dimension, after the 12-hour preservation period in both experimental groups was similar to that of the control group 4 and 6 hours after transplantation. The mean arterial oxygen capacity of the transplanted left lung during ventilation with an inspired oxygen concentration of 40% was also similar in each group. In contrast, the 12-hour preservation of pulmonary function assessed by pulmonary vascular resistance, the accumulation of extravascular lung water, and histologic evidence of alveolar wall injury, interstitial edema, and

  6. Regional pulmonary perfusion following human heart-lung transplantation

    SciTech Connect

    Lisbona, R.; Hakim, T.S.; Dean, G.W.; Langleben, D.; Guerraty, A.; Levy, R.D. )

    1989-08-01

    Ventilation and perfusion scans were obtained in six subjects who had undergone heart-lung transplantation with consequent denervation of the cardiopulmonary axis. Two of the subjects had developed obliterative bronchiolitis, which is believed to be a form of chronic rejection. Their pulmonary function tests demonstrated airflow obstruction and their scintigraphic studies were abnormal. In the remaining four subjects without obstructive airways disease, ventilation and planar perfusion scans were normal. Single photon emission computed tomography imaging of pulmonary perfusion in these patients revealed a layered distribution of blood flow indistinguishable from that of normal individuals. It is concluded that neurogenic mechanisms have little influence on the pattern of local pulmonary blood flow at rest.

  7. State of the Art of Combined Heart-Lung Transplantation for Advanced Cardiac and Pulmonary Dysfunction.

    PubMed

    Idrees, Jay J; Pettersson, Gösta B

    2016-04-01

    Over the last several decades, significant advances and improvements in care of transplant patients have resulted in markedly improved outcomes. A number of options are available for patients with advanced cardiopulmonary dysfunction requiring transplantation. There is a debate about when isolated heart or isolated lung transplantation is no longer possible or advisable and combined heart-lung transplantation is justified. Organ availability and allocation severely limit the latter option to very few well-selected patients. We review practice patterns, trends, and outcomes after triple-organ heart-lung transplant (HLTx) worldwide, as well as our own experience with heart-lung transplant in the modern era. PMID:26922590

  8. Lung and heart-lung transplantation. Evolution and new applications.

    PubMed Central

    Bolman, R M; Shumway, S J; Estrin, J A; Hertz, M I

    1991-01-01

    Heart-lung transplantation (HLT) and lung transplantation (LT) are effective treatment modalities for patients with advanced pulmonary parenchymal or vascular disease. Lung transplantation offers potential advantages over HLT, including reduced pretransplant waiting time and improved efficiency of organ utilization, and is currently being offered to patients formerly treated by HLT. To explore the relative merits of these procedures, the authors examined the results in 44 procedures (23 HLT and 21 LT) in 42 patients transplanted at their institution. Heart-lung transplant recipients included 20 adults and three children (ages 5,5 and 3). Most HLT patients had primary pulmonary hypertension (PPH) (n = 9) or Eisenmenger's syndrome (ES) (n = 8). Twenty-two of twenty-three patients have been long-term survivors (mean follow-up = 17.8 months, Kapaln-Meier survival at 12 months = 85%). Obliterative bronchiolitis (OB) has occurred in five patients (22%), and all have died. Of 21 LTs in 19 patients, nine had obstructive and eight had restrictive lung diseases. Three single-LT (SLT) patients had PPH, and one had ES secondary to a ventricular septal defect. Mean pulmonary artery pressures fell from 55 +/- 6 mm Hg before SLT to 21 +/- 3 mm Hg after SLT; p less than 0.001. Three pediatric patients (ages 4, 10, 17, and 17[re-transplant]) have undergone four SLTs. With mean follow-up of 6.4 months, LT patients have survival at 12 months of 80% (Kaplan-Meier). Lung transplant patients wait a far shorter time for their transplant than do HLT patients (166 vs. 384 days, p less than 0.03). Three patients (19%) have evidence of OB after SLT, with one death. By virtue of equal intermediate-term outcomes, shorter waiting times, and better use of donor organs in comparison with HLT, LT should be offered whenever possible to patients with end-stage pulmonary parenchymal or vascular disease. The authors' pediatric LT and HLT experience (7 treatments in 6 patients) is the largest reported

  9. 78 FR 6122 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-29

    ...: National Heart, Lung, and Blood Institute Special Emphasis Panel SBIR Contract Proposal Pediatric Cardiac MRI Date: February 20, 2013. Time: 2:00 p.m. to 5:00 p.m. Agenda: To review and evaluate...

  10. 78 FR 63483 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-24

    ...: National Heart, Lung, and Blood Institute Special Emphasis Panel; SBIR Phase IIB Bridge Awards. Date...; SBIR Phase IIB Small Market Awards. Date: November 8, 2013. Time: 1:00 p.m., to 5:00 p.m. Agenda:...

  11. 76 FR 71986 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-21

    ... 20814. Contact Person: Tony L Creazzo, Ph.D., Scientific Review Officer, Office of Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7180, Bethesda, MD...

  12. 77 FR 16246 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-20

    ... 20814. Contact Person: Tony L Creazzo, Ph.D., Scientific Review Officer, Office of Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7180, Bethesda, MD...

  13. 78 FR 48880 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-12

    ... Drive, Room 7190, Bethesda, MD 20892 (Telephone Conference Call). Contact Person: Keary A Cope, Ph.D... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Randomized Trial...

  14. Disruption of the aortic anastomosis after heart-lung transplantation.

    PubMed

    Dowling, R D; Baladi, N; Zenati, M; Dummer, J S; Kormos, R L; Armitage, J M; Yousem, S A; Hardesty, R L; Griffith, B P

    1990-01-01

    Disruption of the aorta at the anastomotic site occurred in 4 of 66 consecutive heart-lung transplant recipients and was associated with a 100% mortality. In 3 of these patients, Candida either was cultured from the suture line or was seen in the wall of the aorta at postmortem examination. In 2 of these 3 patients, cultures of material from the donor trachea taken at the time of explanation grew Candida species. Two patients were seen with sudden massive hemorrhage on postoperative day 26 and postoperative day 28. One patient experienced acute decompensation due to right ventricular outflow tract obstruction on postoperative day 30, and the remaining patient was seen 7 months postoperatively with obstruction of both the left main bronchus and the right pulmonary artery caused by extrinsic compression by an aortic pseudoaneurysm. A high index of suspicion should be maintained when transplanting lungs containing Candida species, as we believe there is substantial evidence of donor transmission of the fungal agents. We now include amphotericin B in our antibiotic prophylactic regimen in an attempt to prevent fungal infection because previous treatment has been uniformly unsuccessful. Furthermore, we wrap both the trachea and the aorta with omentum to lessen the likelihood of mediastinal spread of infection to the aortic suture line. PMID:2297258

  15. 76 FR 61720 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-05

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... Blood Institute Special Emphasis Panel, Genomic Research in AAT-Deficiency and Sarcoidosis--Genomics...

  16. 76 FR 19103 - National Heart, Lung, and Blood Institute; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-06

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of..., PhD, Director, National Center on Sleep Disorders Research, Division of Lung Diseases, National Heart... Center for Sleep Disorders Research; 93.837, Heart and ] Vascular Diseases Research; 93.838,...

  17. 77 FR 66853 - National Heart, Lung, and Blood Institute Amended Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-07

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute Amended Notice of Meeting Notice is hereby given of a change in the meeting of the Board of Scientific Counselors, NHLBI, October 29, 2012, 09:00 a.m. to October...

  18. 75 FR 9907 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-04

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed Meetings Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is hereby given of the...

  19. 75 FR 70273 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-17

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed Meetings Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is hereby given of the...

  20. A comparison of antifibrillatory drugs in the heart-lung preparation

    PubMed Central

    Rand, M. J.; Walker, J. M.

    1958-01-01

    Quinidine, amethocaine, Trasentin and atropine have been tested for their ability to stop atrial fibrillation produced in the heart-lung preparation of the dog by stimulating the right atrium in the presence of acetylcholine. The results suggest that atropine acts by specifically antagonizing acetylcholine, but that amethocaine and Trasentin act chiefly by virtue of their quinidine-like properties. PMID:13523146

  1. 77 FR 64818 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-23

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed Meetings Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is hereby given of the...

  2. The cough response to ultrasonically nebulized distilled water in heart-lung transplantation patients

    SciTech Connect

    Higenbottam, T.; Jackson, M.; Woolman, P.; Lowry, R.; Wallwork, J.

    1989-07-01

    As a result of clinical heart-lung transplantation, the lungs are denervated below the level of the tracheal anastomosis. It has been questioned whether afferent vagal reinnervation occurs after surgery. Here we report the cough frequency, during inhalation of ultrasonically nebulized distilled water, of 15 heart-lung transplant patients studied 6 wk to 36 months after surgery. They were compared with 15 normal subjects of a similar age and sex. The distribution of the aerosol was studied in five normal subjects using /sup 99m/technetium diethylene triamine pentaacetate (/sup 99m/Tc-DTPA) in saline. In seven patients, the sensitivity of the laryngeal mucosa to instilled distilled water (0.2 ml) was tested at the time of fiberoptic bronchoscopy by recording the cough response. Ten percent of the aerosol was deposited onto the larynx and trachea, 56% on the central airways, and 34% in the periphery of the lung. The cough response to the aerosol was strikingly diminished in the patients compared with normal subjects (p less than 0.001), but all seven patients coughed when distilled water was instilled onto the larynx. As expected, the laryngeal mucosa of heart-lung transplant patients remains sensitive to distilled water. However, the diminished coughing when the distilled water is distributed by aerosol to the central airways supports the view that vagal afferent nerves do not reinnervate the lungs after heart-lung transplantation, up to 36 months after surgery.

  3. 76 FR 63625 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-13

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed Meetings Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is hereby given of the...

  4. 78 FR 6127 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-29

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... Transition Scientist Award. Date: February 21-22, 2013. Time: 8:00 a.m. to 5:00 p.m. Agenda: To review...

  5. 77 FR 5261 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-02

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed Meetings Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is hereby given of the...

  6. 78 FR 76849 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-19

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is hereby given of the following...

  7. 75 FR 156 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-04

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is hereby given of the following...

  8. Epstein-Barr virus associated graft failure following heart/lung transplantation.

    PubMed Central

    Egan, J J; Stewart, J P; Hasleton, P S; Yonan, N; Bishop, P; Arrand, J R; Rahman, A N; Carroll, K B; Woodcock, A A

    1996-01-01

    A case is described of late pulmonary graft failure in a heart/lung transplant recipient. The major characteristics were alveolar fibrosis and a restrictive physiological deficit. Epstein-Barr virus was implicated as an aetiological agent using immunohistochemical analysis and by a response to treatment with ganciclovir. Images PMID:8958903

  9. 75 FR 21644 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-26

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed Meetings Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is hereby given of the...

  10. The Role of School Health Education in Preventing Heart, Lung, and Blood Diseases.

    ERIC Educational Resources Information Center

    Kolbe, Lloyd J.; Newman, Ian M.

    1984-01-01

    This article reviews the scope and dynamics of heart, lung, and blood diseases and explains the need for research on primary prevention programs for children. Suggestions for school health education programs that contribute to disease prevention are delineated. (Author/DF)

  11. 76 FR 12744 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-08

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed Meetings Pursuant to section 10(d) of the Federal Advisory Committee Act, as ] amended (5 U.S.C. App.), notice is hereby given of the...

  12. Paediatric heart failure research: role of the National Heart, Lung, and Blood Institute.

    PubMed

    Burns, Kristin M

    2015-08-01

    The National Heart, Lung, and Blood Institute, of the National Institutes of Health, is committed to supporting research in paediatric heart failure. The Institute's support of paediatric heart failure research includes both investigator-initiated grants and Institute initiatives. There were 107 funded grants in paediatric heart failure over the past 20 years in basic, translational and clinical research, technology development, and support of registries. Such research includes a broad diversity of scientific topics and approaches. The Institute also supports several initiatives for paediatric heart failure, including the Pediatric Circulatory Support Program, the Pumps for Kids, Infants, and Neonates (PumpKIN) Program, PediMACS, and the Pediatric Heart Network. This review article describes the National Heart, Lung, and Blood Institute's past, present, and future efforts to promote a better understanding of paediatric heart failure, with the ultimate goal of improving outcomes. PMID:26377724

  13. A novel approach in extracorporeal circulation: individual, integrated, and interactive heart-lung assist (I3-Assist).

    PubMed

    Wagner, Georg; Schlanstein, Peter; Fiehe, Sandra; Kaufmann, Tim; Kopp, Rüdger; Bensberg, Ralf; Schmitz-Rode, Thomas; Steinseifer, Ulrich; Arens, Jutta

    2014-04-01

    Extracorporeal life support (ECLS) is a well-established technique for the treatment of different cardiac and pulmonary diseases, e.g., congenital heart disease and acute respiratory distress syndrome. Additionally, severely ill patients who cannot be weaned from the heart-lung machine directly after surgery have to be put on ECLS for further therapy. Although both systems include identical components, a seamless transition is not possible yet. The adaption of the circuit to the patients' size and demand is limited owing to the components available. The project I³-Assist aims at a novel concept for extracorporeal circulation. To better match the patient's therapeutic demand of support, an individual number of one-size oxygenators and heat exchangers will be combined. A seamless transition between cardiopulmonary bypass and ECLS will be possible as well as the exchange of components during therapy to enhance circuit maintenance throughout long-term support. Until today, a novel oxygenator and heat exchanger along with a simplified manufacturing protocol have been established. The first layouts of the unit to allow the spill- and bubble-free connection and disconnection of modules as well as improved cannulas and a rotational pump are investigated using computational fluid dynamics. Tests were performed according to current guidelines in vitro and in vivo. The test results show the feasibility and potential of the concept. PMID:24327525

  14. Autoperfused working heart-lung preparation versus hypothermic cardiopulmonary preservation for transplantation.

    PubMed

    Adachi, H; Fraser, C D; Kontos, G J; Borkon, A M; Hutchins, G M; Galloway, E; Brawn, J; Reitz, B A; Baumgartner, W A

    1987-01-01

    The effects of preserving the heart and lungs with an autoperfused working heart-lung preparation or simple hypothermia via cardiopulmonary bypass were studied in 18 dairy calves that had combined heart-lung transplantation. Group 1 (n = 6) served as the control group in which animals were cooled with cardiopulmonary bypass and immediately had allotransplantations. In group 2 (n = 6), cardiopulmonary function was maintained in the autoperfusion circuit for 4 hours, followed by transplantation. In group 3 (n = 6), the organs were harvested after cooling by cardiopulmonary bypass, stored in cold (4 degrees C) saline solution for 4 hours, and then transplanted. Cardiopulmonary function was compared between the three groups for 6 hours after implantation. Cardiac function was determined by the ratio of the end-systolic pressure to end-systolic dimension. Pulmonary function was evaluated by the measurement of extravascular lung water, arterial oxygenation on 100% inspired oxygen static lung compliance, and histologic lung injury score. All measurements in groups 2 and 3 were similar to those of the control group at 6 hours after implantation. One may use either the hypothermic cardiopulmonary preservation method after cardiopulmonary bypass or the autoperfused working heart-lung preparation for distant organ procurement and expect adequate cardiopulmonary function after transplantation. PMID:3119800

  15. Center for Fetal Monkey Gene Transfer for Heart, Lung, and Blood Diseases: An NHLBI Resource for the Gene Therapy Community

    PubMed Central

    Skarlatos, Sonia I.

    2012-01-01

    Abstract The goals of the National Heart, Lung, and Blood Institute (NHLBI) Center for Fetal Monkey Gene Transfer for Heart, Lung, and Blood Diseases are to conduct gene transfer studies in monkeys to evaluate safety and efficiency; and to provide NHLBI-supported investigators with expertise, resources, and services to actively pursue gene transfer approaches in monkeys in their research programs. NHLBI-supported projects span investigators throughout the United States and have addressed novel approaches to gene delivery; “proof-of-principle”; assessed whether findings in small-animal models could be demonstrated in a primate species; or were conducted to enable new grant or IND submissions. The Center for Fetal Monkey Gene Transfer for Heart, Lung, and Blood Diseases successfully aids the gene therapy community in addressing regulatory barriers, and serves as an effective vehicle for advancing the field. PMID:22974119

  16. Elucidating nature's solutions to heart, lung, and blood diseases and sleep disorders.

    PubMed

    Carey, Hannah V; Martin, Sandra L; Horwitz, Barbara A; Yan, Lin; Bailey, Shannon M; Podrabsky, Jason; Storz, Jay F; Ortiz, Rudy M; Wong, Renee P; Lathrop, David A

    2012-03-30

    Evolution has provided a number of animal species with extraordinary phenotypes. Several of these phenotypes allow species to survive and thrive in environmental conditions that mimic disease states in humans. The study of evolved mechanisms responsible for these phenotypes may provide insights into the basis of human disease and guide the design of new therapeutic approaches. Examples include species that tolerate acute or chronic hypoxemia like deep-diving mammals and high-altitude inhabitants, as well as those that hibernate and interrupt their development when exposed to adverse environments. The evolved traits exhibited by these animal species involve modifications of common biological pathways that affect metabolic regulation, organ function, antioxidant defenses, and oxygen transport. In 2006, the National Heart, Lung, and Blood Institute released a funding opportunity announcement to support studies that were designed to elucidate the natural molecular and cellular mechanisms of adaptation in species that tolerate extreme environmental conditions. The rationale for this funding opportunity is detailed in this article, and the specific evolved mechanisms examined in the supported research are described. Also highlighted are past medical advances achieved through the study of animal species that have evolved extraordinary phenotypes as well as the expectations for new understanding of nature's solutions to heart, lung, blood, and sleep disorders through future research in this area. PMID:22461362

  17. National Heart, Lung, and Blood Institute and the translation of cardiovascular discoveries into therapeutic approaches.

    PubMed

    Galis, Zorina S; Black, Jodi B; Skarlatos, Sonia I

    2013-04-26

    The molecular causes of ≈4000 medical conditions have been described, yet only 5% have associated therapies. For decades, the average time for drug development through approval has taken 10 to 20 years. In recent years, the serious challenges that confront the private sector have made it difficult to capitalize on new opportunities presented by advances in genomics and cellular therapies. Current trends are disturbing. Pharmaceutical companies are reducing their investments in research, and biotechnology companies are struggling to obtain venture funds. To support early-stage translation of the discoveries in basic science, the National Institutes of Health and the National Heart, Lung, and Blood Institute have developed new approaches to facilitating the translation of basic discoveries into clinical applications and will continue to develop a variety of programs that create teams of academic investigators and industry partners. The goal of these programs is to maximize the public benefit of investment of taxpayer dollars in biomedical research and to lessen the risk required for industry partners to make substantial investments. This article highlights several examples of National Heart, Lung, and Blood Institute-initiated translational programs and National Institutes of Health translational resources designed to catalyze and enable the earliest stages of the biomedical product development process. The translation of latest discoveries into therapeutic approaches depends on continued federal funding to enhance the early stages of the product development process and to stimulate and catalyze partnerships between academia, industry, and other sources of capital. PMID:23620235

  18. Clinical Outcomes of Heart-Lung Transplantation: Review of 10 Single-Center Consecutive Patients

    PubMed Central

    Yun, Jae Kwang; Choi, Se Hoon; Park, Seung-Il

    2016-01-01

    Background Heart-lung transplantation (HLT) has provided hope to patients with end-stage lung disease and irreversible heart dysfunction. We reviewed the clinical outcomes of 10 patients who underwent heart-lung transplantation at Asan Medical Center. Methods Between July 2010 and August 2014, a total of 11 patients underwent HLT at Asan Medical Center. After excluding one patient who underwent concomitant liver transplantation, 10 patients were enrolled in our study. We reviewed the demographics of the donors and the recipients’ baseline information, survival rate, cause of death, and postoperative complications. All patients underwent follow-up, with a mean duration of 26.1±16.7 months. Results Early death occurred in two patients (20%) due to septic shock. Late death occurred in three patients (38%) due to bronchiolitis obliterans (n=2) and septic shock (n=1), although these patients survived for 22, 28, and 42 months, respectively. The actuarial survival rates at one year, two years, and three years after HLT were 80%, 67%, and 53%, respectively. Conclusion HLT is a procedure that is rarely performed in Korea, even in medical centers with large heart and lung transplant programs. In order to achieve acceptable clinical outcomes, it is critical to carefully choose the donor and the recipient and to be certain that all aspects of the transplant procedure are planned in advance with the greatest care. PMID:27298792

  19. A Review of Organ Transplantation: Heart, Lung, Kidney, Liver, and Simultaneous Liver-Kidney.

    PubMed

    Scheuher, Cynthia

    2016-01-01

    Heart, lung, kidney, liver, and simultaneous liver-kidney transplants share many features. They all follow the same 7-step process, the same 3 immunosuppressant medications, and the same reason for organ transplantation. Organs are transplanted because of organ failure. The similarities end there. Each organ has its unique causes for failure. Each organ also has its own set of criteria that must be met prior to transplantation. Simultaneous liver-kidney transplant criteria vary per transplant center but are similar in nature. Both the criteria required and the 7-step process are described by the United Network of Organ Sharing, which is a private, nonprofit organization, under contract with the US Department of Health and Human Services. Its function is to increase the number of transplants, improve survival rates after transplantation, promote safe transplant practices, and endorse efficiency. The purpose of this article is to review the reasons transplant is needed, specifically heart, lung, kidney, liver, and simultaneous liver-kidney, and a brief overview of the transplant process including criteria used, contraindications, and medications prescribed. PMID:27254636

  20. The First Successful Heart-Lung Transplant in a Korean Child with Humidifier Disinfectant-Associated Interstitial Lung Disease

    PubMed Central

    Kim, Yong-Hee; Hong, Sang-Bum

    2016-01-01

    From 2006 to 2011, an outbreak of a particular type of childhood interstitial lung disease occurred in Korea. The condition was intractable and progressed to severe respiratory failure, with a high mortality rate. Moreover, in several familial cases, the disease affected young women and children simultaneously. Epidemiologic, animal, and post-interventional studies identified the cause as inhalation of humidifier disinfectants. Here, we report a 4-year-old girl who suffered from severe progressive respiratory failure. She could survive by 100 days of extracorporeal membrane oxygenation support and finally, underwent heart-lung transplantation. This is the first successful pediatric heart-lung transplantation carried out in Korea. PMID:27134508

  1. The First Successful Heart-Lung Transplant in a Korean Child with Humidifier Disinfectant-Associated Interstitial Lung Disease.

    PubMed

    Jhang, Won Kyoung; Park, Seong Jong; Lee, Eun; Yang, Song I; Hong, Soo Jong; Seo, Ju-Hee; Kim, Hyung-Young; Park, Jeong-Jun; Yun, Tae-Jin; Kim, Hyeong Ryul; Kim, Yong-Hee; Kim, Dong Kwan; Park, Seung-Il; Lee, Sang-Oh; Hong, Sang-Bum; Shim, Tae-Sun; Choi, In-Cheol; Yu, Jinho

    2016-05-01

    From 2006 to 2011, an outbreak of a particular type of childhood interstitial lung disease occurred in Korea. The condition was intractable and progressed to severe respiratory failure, with a high mortality rate. Moreover, in several familial cases, the disease affected young women and children simultaneously. Epidemiologic, animal, and post-interventional studies identified the cause as inhalation of humidifier disinfectants. Here, we report a 4-year-old girl who suffered from severe progressive respiratory failure. She could survive by 100 days of extracorporeal membrane oxygenation support and finally, underwent heart-lung transplantation. This is the first successful pediatric heart-lung transplantation carried out in Korea. PMID:27134508

  2. The Relationship between National Heart, Lung, and Blood Institute Weight Guidelines and Concurrent Medical Costs in a Manufacturing Population.

    ERIC Educational Resources Information Center

    Wang, Feifei; Schultz, Alyssa B.; Musich, Shirley; McDonald, Tim; Hirschland, David; Edington, Dee W.

    2003-01-01

    Explored the relationship between the 1998 National Heart, Lung, and Blood Institute (NHLBI) weight guidelines and concurrent medical costs among 177,971 employees, retirees, and adult dependents from a nationwide manufacturing corporation. Results indicated that the six weight groups defined by the NHLBI guidelines were consistent with concurrent…

  3. [Extended hypothermic heart-lung preservation system for cardiopulmonary preservation with retrograde coronary sinus perfusion and lung immersion].

    PubMed

    Senoo, Y; Bando, K; Tago, M; Seno, S; Teraoka, H; Teramoto, S

    1990-09-01

    One major restriction of clinical heart-lung transplantation has been the inability to provide extended hypothermic organ preservation. We examined whether core-cooling, retrograde heart perfusion and lung immersion could provide adequate cardiopulmonary preservation. Hence, donor dogs were placed on cardiopulmonary bypass, and rapidly cooled to 15 degrees C. Then heterotopic heart unilateral left lung transplantations were performed. In control group I (n = 5), hearts and lungs were harvested following core-cooling and cardioplegic arrest, and transplanted immediately. In experimental group II (n = 5), heart-lung blocks were similarly excised but stored at 4 degrees C for 12 hours and then transplanted. During preservation, the lungs were immersed in the extracellular solution. For the heart, non-recirculating retrograde coronary sinus perfusion was performed with oxygenated intracellular solution containing perfluorochemicals. Myocardial function determined by the ratio of end-systolic pressure to end-systolic dimension in the experimental group was similar to that in controls. Although pulmonary vascular resistance and extravascular lung water of the experimental group was higher than those in control group, arterial oxygenation was similar in both groups. Thus, extended heart-lung preservation with core-cooling, retrograde heart perfusion and lung immersion technique could be achieved for heart-lung transplantation. PMID:2246529

  4. Conformal piezoelectric energy harvesting and storage from motions of the heart, lung, and diaphragm

    PubMed Central

    Dagdeviren, Canan; Yang, Byung Duk; Su, Yewang; Tran, Phat L.; Joe, Pauline; Anderson, Eric; Xia, Jing; Doraiswamy, Vijay; Dehdashti, Behrooz; Feng, Xue; Lu, Bingwei; Poston, Robert; Khalpey, Zain; Ghaffari, Roozbeh; Huang, Yonggang; Slepian, Marvin J.; Rogers, John A.

    2014-01-01

    Here, we report advanced materials and devices that enable high-efficiency mechanical-to-electrical energy conversion from the natural contractile and relaxation motions of the heart, lung, and diaphragm, demonstrated in several different animal models, each of which has organs with sizes that approach human scales. A cointegrated collection of such energy-harvesting elements with rectifiers and microbatteries provides an entire flexible system, capable of viable integration with the beating heart via medical sutures and operation with efficiencies of ∼2%. Additional experiments, computational models, and results in multilayer configurations capture the key behaviors, illuminate essential design aspects, and offer sufficient power outputs for operation of pacemakers, with or without battery assist. PMID:24449853

  5. Text Categorization of Heart, Lung, and Blood Studies in the Database of Genotypes and Phenotypes (dbGaP) Utilizing n-grams and Metadata Features

    PubMed Central

    Ross, Mindy K.; Lin, Ko-Wei; Truong, Karen; Kumar, Abhishek; Conway, Mike

    2013-01-01

    The database of Genotypes and Phenotypes (dbGaP) allows researchers to understand phenotypic contribution to genetic conditions, generate new hypotheses, confirm previous study results, and identify control populations. However, effective use of the database is hindered by suboptimal study retrieval. Our objective is to evaluate text classification techniques to improve study retrieval in the context of the dbGaP database. We utilized standard machine learning algorithms (naive Bayes, support vector machines, and the C4.5 decision tree) trained on dbGaP study text and incorporated n-gram features and study metadata to identify heart, lung, and blood studies. We used the χ2 feature selection algorithm to identify features that contributed most to classification performance and experimented with dbGaP associated PubMed papers as a proxy for topicality. Classifier performance was favorable in comparison to keyword-based search results. It was determined that text categorization is a useful complement to document retrieval techniques in the dbGaP. PMID:23926434

  6. Prevention of atrial fibrillation: report from a national heart, lung, and blood institute workshop.

    PubMed

    Benjamin, Emelia J; Chen, Peng-Sheng; Bild, Diane E; Mascette, Alice M; Albert, Christine M; Alonso, Alvaro; Calkins, Hugh; Connolly, Stuart J; Curtis, Anne B; Darbar, Dawood; Ellinor, Patrick T; Go, Alan S; Goldschlager, Nora F; Heckbert, Susan R; Jalife, José; Kerr, Charles R; Levy, Daniel; Lloyd-Jones, Donald M; Massie, Barry M; Nattel, Stanley; Olgin, Jeffrey E; Packer, Douglas L; Po, Sunny S; Tsang, Teresa S M; Van Wagoner, David R; Waldo, Albert L; Wyse, D George

    2009-02-01

    The National Heart, Lung, and Blood Institute convened an expert panel April 28 to 29, 2008, to identify gaps and recommend research strategies to prevent atrial fibrillation (AF). The panel reviewed the existing basic scientific, epidemiological, and clinical literature about AF and identified opportunities to advance AF prevention research. After discussion, the panel proposed the following recommendations: (1) enhance understanding of the epidemiology of AF in the population by systematically and longitudinally investigating symptomatic and asymptomatic AF in cohort studies; (2) improve detection of AF by evaluating the ability of existing and emerging methods and technologies to detect AF; (3) improve noninvasive modalities for identifying key components of cardiovascular remodeling that promote AF, including genetic, fibrotic, autonomic, structural, and electrical remodeling markers; (4) develop additional animal models reflective of the pathophysiology of human AF; (5) conduct secondary analyses of already-completed clinical trials to enhance knowledge of potentially effective methods to prevent AF and routinely include AF as an outcome in ongoing and future cardiovascular studies; and (6) conduct clinical studies focused on secondary prevention of AF recurrence, which would inform future primary prevention investigations. PMID:19188521

  7. Physicians’ Lack of Adherence to National Heart, Lung, and Blood Institute Guidelines for Pediatric Lipid Screening

    PubMed Central

    Valle, Christopher W.; Binns, Helen J.; Quadri-Sheriff, Maheen; Benuck, Irwin; Patel, Angira

    2015-01-01

    Objectives To determine adherence to the 2011 National Heart, Lung, and Blood Institute lipid screening guidelines and identify patient factors promoting screening. Methods Records of children who received well-child care at age 11 years and turned 12 in 2013 were reviewed. Subjects were stratified by guideline-defined dyslipidemia risk based on documented medical or family history risk factors. We defined adherence as the order of a lipid profile when age 11 years or completed lipid screening at 9 to 10 years. Results Of 298 subjects, 42% were assigned to the dyslipidemia high-risk subgroup. Records of 27.2% demonstrated adherence. Fifty-six percent of high-risk subjects versus 6% of their non-high-risk counterparts received lipid screening by age 12 (P < .001). Among screened subjects, history of obesity and parental history of dyslipidemia were significantly associated with lipid testing. Conclusions Lipid screening rates were low. Strategies to increase lipid screening in the primary care setting are needed. PMID:25813383

  8. Donor core-cooling provides improved static preservation for heart-lung transplantation.

    PubMed

    Fraser, C D; Tamura, F; Adachi, H; Kontos, G J; Brawn, J; Hutchins, G M; Borkon, A M; Reitz, B A; Baumgartner, W A

    1988-03-01

    Twenty-three dairy calves underwent heart-lung allotransplantation after donor organs were procured using either donor core-cooling through cardiopulmonary bypass (CPB) or pulmonary artery flush (PAF) to assess which method provides optimal graft preservation. In Groups 1 (control) and 2, donors were cooled to 15 degrees C on CPB and organs were either immediately transplanted (Group 1) or stored in saline solution (4 degrees C) for 4 hours (Group 2) prior to transplantation. In Group 3, donors were pretreated with prostaglandin E1 prior to PAF with modified Euro-Collins solution. Organs were stored in saline solution (4 degrees C) for 4 hours and were then transplanted. Acute cardiopulmonary function following transplantation was assessed by the ratio of end-systolic pressure to end-systolic dimension, extravascular lung water (EVLW), lung compliance, arterial oxygenation, and lung biopsy. Cardiac function after the transplantation procedure was similar in all groups, but EVLW values and lung biopsy scores were worse after PAF. Arterial O2 tension appeared lower after PAF, but not significantly so. Core-cooling provides superior static preservation and thus improved graft function in the acute bovine model. PMID:3126721

  9. A no-flush, core-cooling technique for successful cardiopulmonary preservation in heart-lung transplantation.

    PubMed

    Kontos, G J; Adachi, H; Borkon, M A; Cameron, D E; Baumgartner, W A; Hutchins, G M; Brawn, J; Reitz, B A

    1987-12-01

    In order to determine whether a no-flush, core-cooling technique could provide extended heart-lung preservation, we placed donor calves on cardiopulmonary bypass and instituted rapid cooling to 15 degrees C during the continuous infusion of isoproterenol. The heart and lungs were harvested after the administration of a cardioplegic solution through the aortic root. In the control group (N = 5), heart and lungs were orthotopically allotransplanted immediately. In the preserved group (N = 5), heart and lungs were similarly excised but were stored in a normal saline bath at 4 degrees C for approximately 4 hours and then transplanted. Both groups received isoproterenol during reperfusion and were studied for 6 hours after implantation. A load independent analysis of myocardial function was done by determining with a sonomicrometer the ratio of the end-systolic pressure to the end-systolic dimension. Pulmonary preservation was evaluated by measurement of extravascular lung water with a double-indicator dilution method, arterial oxygenation on 100% inspired oxygen, and serial lung biopsies. Myocardial and pulmonary function after 4 hours of static preservation was found to be similar to controls. No-flush, core-cooling with cardiopulmonary bypass provides adequate cardiorespiratory function after acute bovine heart-lung allotransplantation. With the use of this technique, successful extended cold ischemic cardiopulmonary preservation for heart-lung transplantation may be achieved. PMID:3119946

  10. Extended cardiopulmonary preservation for heart-lung transplantation: a comparative study of superoxide dismutase.

    PubMed

    Bando, K; Tago, M; Teraoka, H; Seno, S; Senoo, Y; Teramoto, S

    1989-01-01

    We examined an 8-hour cardiopulmonary preservation technique and the role of free radical-induced injury during cardiopulmonary preservation and transplantation. Hence, donor dogs were placed on cardiopulmonary bypass, rapidly cooled to 15 degrees C, and heterotopic heart-unilateral left lung transplantations were performed. In group 1 (n = 5), hearts and lungs were transplanted immediately after core-cooling and cardioplegic arrest. In groups 2 to 5 (n = 5 in each group), heart-lung blocks were excised and stored at 4 degrees C for 8 hours before transplantation. During preservation hearts were perfused (20 mm Hg) with oxygenated extracellular solution (pH 7.4, 410 m0sm/L) and the lungs immersed in the same solution. In groups 3 through 5 recombinant human superoxide distumase (r,h-SOD, total 40 mg/kg) was administered during either donor cooling, donor preservation, or just before and during reperfusion, respectively. Load independent analysis of myocardial function was assessed by determining the ratio of the end-systolic pressure to end-systolic dimension. Pulmonary preservation was evaluated by determination of extravascular lung water of the implanted left lung, arterial oxygenation on 40% inspired oxygen, and pulmonary vascular resistance. Although arterial oxygenation was similar in each group, pulmonary vascular resistance was increased in groups 2 through 4 after implantation. Furthermore, in groups 2 and 4 impaired myocardial function and increased extravascular lung water were observed. Administration of r,h-SOD, however, just before and during reperfusion significantly enhanced cardiopulmonary preservation. These results indicate that free radical-induced injury is primarily the result of reperfusion. Thus the best time for administration of r,h-SOD is before and during reperfusion.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:2494311

  11. [Therapeutic Drug Management for Transplanted Women with a Planned Pregnancy: About Two Cases of Lung and Heart-lung Transplantation].

    PubMed

    Zecchini, Céline; Chanoine, Sébastien; Chapuis, Claire; Claustre, Johanna; Schir, Edith; Allenet, Benoît; Saint Raymond, Christel; Bedouch, Pierrick

    2015-01-01

    Advances in lung transplantation allow the women of childbearing age to consider becoming mothers. When planning to become pregnant, a therapeutic drug management of immunosuppressive drugs and associated therapies is required. It must take into account teratogenic and fetotoxic drugs, as well as pharmacokinetic changes encountered during pregnancy. Increasingly data are currently available on the management of immunosuppressive drugs and associated therapies during pregnancy. We report the case management of drug therapy before and during pregnancy in two patients after a lung or heart-lung transplantation. To prevent the emergence of complications for mother and child, a literature review has been necessary to manage drug therapies of each patient. PMID:26223163

  12. Report of the National Heart, Lung, and Blood Institute Working Group: An Integrated Network for Congenital Heart Disease Research.

    PubMed

    Pasquali, Sara K; Jacobs, Jeffrey P; Farber, Gregory K; Bertoch, David; Blume, Elizabeth D; Burns, Kristin M; Campbell, Robert; Chang, Anthony C; Chung, Wendy K; Riehle-Colarusso, Tiffany; Curtis, Lesley H; Forrest, Christopher B; Gaynor, William J; Gaies, Michael G; Go, Alan S; Henchey, Paul; Martin, Gerard R; Pearson, Gail; Pemberton, Victoria L; Schwartz, Steven M; Vincent, Robert; Kaltman, Jonathan R

    2016-04-01

    The National Heart, Lung, and Blood Institute convened a working group in January 2015 to explore issues related to an integrated data network for congenital heart disease research. The overall goal was to develop a common vision for how the rapidly increasing volumes of data captured across numerous sources can be managed, integrated, and analyzed to improve care and outcomes. This report summarizes the current landscape of congenital heart disease data, data integration methodologies used across other fields, key considerations for data integration models in congenital heart disease, and the short- and long-term vision and recommendations made by the working group. PMID:27045129

  13. Point-of-Care Technologies for the Advancement of Precision Medicine in Heart, Lung, Blood, and Sleep Disorders

    PubMed Central

    Jamieson, Brian G.; Chui, Chi On; Mao, Yufei; Shin, Kyeong-Sik; Huang, Tony Jun; Huang, Po-Hsun; Ren, Liqiang; Adhikari, Bishow; Chen, Jue; Iturriaga, Erin

    2016-01-01

    The commercialization of new point of care technologies holds great potential in facilitating and advancing precision medicine in heart, lung, blood, and sleep (HLBS) disorders. The delivery of individually tailored health care to a patient depends on how well that patient’s health condition can be interrogated and monitored. Point of care technologies may enable access to rapid and cost-effective interrogation of a patient’s health condition in near real time. Currently, physiological data are largely limited to single-time-point collection at the hospital or clinic, whereas critical information on some conditions must be collected in the home, when symptoms occur, or at regular intervals over time. A variety of HLBS disorders are highly dependent on transient variables, such as patient activity level, environment, time of day, and so on. Consequently, the National Heart Lung and Blood Institute sponsored a request for applications to support the development and commercialization of novel point-of-care technologies through small businesses (RFA-HL-14-011 and RFA-HL-14-017). Three of the supported research projects are described to highlight particular point-of-care needs for HLBS disorders and the breadth of emerging technologies. While significant obstacles remain to the commercialization of such technologies, these advancements will be required to achieve precision medicine. PMID:27602308

  14. Point-of-Care Technologies for the Advancement of Precision Medicine in Heart, Lung, Blood, and Sleep Disorders.

    PubMed

    Bigelow, Mary Emma Gorham; Jamieson, Brian G; Chui, Chi On; Mao, Yufei; Shin, Kyeong-Sik; Huang, Tony Jun; Huang, Po-Hsun; Ren, Liqiang; Adhikari, Bishow; Chen, Jue; Iturriaga, Erin

    2016-01-01

    The commercialization of new point of care technologies holds great potential in facilitating and advancing precision medicine in heart, lung, blood, and sleep (HLBS) disorders. The delivery of individually tailored health care to a patient depends on how well that patient's health condition can be interrogated and monitored. Point of care technologies may enable access to rapid and cost-effective interrogation of a patient's health condition in near real time. Currently, physiological data are largely limited to single-time-point collection at the hospital or clinic, whereas critical information on some conditions must be collected in the home, when symptoms occur, or at regular intervals over time. A variety of HLBS disorders are highly dependent on transient variables, such as patient activity level, environment, time of day, and so on. Consequently, the National Heart Lung and Blood Institute sponsored a request for applications to support the development and commercialization of novel point-of-care technologies through small businesses (RFA-HL-14-011 and RFA-HL-14-017). Three of the supported research projects are described to highlight particular point-of-care needs for HLBS disorders and the breadth of emerging technologies. While significant obstacles remain to the commercialization of such technologies, these advancements will be required to achieve precision medicine. PMID:27602308

  15. Cardiovascular epidemiology in a changing world--challenges to investigators and the National Heart, Lung, and Blood Institute.

    PubMed

    Sorlie, Paul D; Bild, Diane E; Lauer, Michael S

    2012-04-01

    Over the past 60 years, revolutionary discoveries made by epidemiologists have contributed to marked declines in cardiovascular disease morbidity and mortality. Now, in an era of increasingly constrained resources, researchers in cardiovascular epidemiology face a number of challenges that call for novel, paradigm-shifting approaches. In this paper, the authors pose to the community 4 critical questions: 1) How can we avoid wasting resources on studies that provide little incremental knowledge? 2) How can we assure that we direct our resources as economically as possible towards innovative science? 3) How can we be nimble, responding quickly to new opportunities? 4) How can we identify prospectively the most meritorious research questions? Senior program staff at the National Heart, Lung, and Blood Institute invite the epidemiology community to join them in an ongoing Web-based blog conversation so that together we might develop novel approaches that will facilitate the next generation of high-impact discoveries. PMID:22415032

  16. Cardiovascular Epidemiology in a Changing World—Challenges to Investigators and the National Heart, Lung, and Blood Institute

    PubMed Central

    Sorlie, Paul D.; Bild, Diane E.; Lauer, Michael S.

    2012-01-01

    Over the past 60 years, revolutionary discoveries made by epidemiologists have contributed to marked declines in cardiovascular disease morbidity and mortality. Now, in an era of increasingly constrained resources, researchers in cardiovascular epidemiology face a number of challenges that call for novel, paradigm-shifting approaches. In this paper, the authors pose to the community 4 critical questions: 1) How can we avoid wasting resources on studies that provide little incremental knowledge? 2) How can we assure that we direct our resources as economically as possible towards innovative science? 3) How can we be nimble, responding quickly to new opportunities? 4) How can we identify prospectively the most meritorious research questions? Senior program staff at the National Heart, Lung, and Blood Institute invite the epidemiology community to join them in an ongoing Web-based blog conversation so that together we might develop novel approaches that will facilitate the next generation of high-impact discoveries. PMID:22415032

  17. Strategic transformation of population studies: recommendations of the working group on epidemiology and population sciences from the National Heart, Lung, and Blood Advisory Council and Board of External Experts.

    PubMed

    Roger, Véronique L; Boerwinkle, Eric; Crapo, James D; Douglas, Pamela S; Epstein, Jonathan A; Granger, Christopher B; Greenland, Philip; Kohane, Isaac; Psaty, Bruce M

    2015-03-15

    In 2013, the National Heart, Lung, and Blood Institute assembled a working group on epidemiology and population sciences from its Advisory Council and Board of External Experts. The working group was charged with making recommendations to the National Heart, Lung, and Blood Advisory Council about how the National Heart, Lung, and Blood Institute could take advantage of new scientific opportunities and delineate future directions for the epidemiology of heart, lung, blood, and sleep diseases. Seven actionable recommendations were proposed for consideration. The themes included 1) defining the compelling scientific questions and challenges in population sciences and epidemiology of heart, lung, blood, and sleep diseases; 2) developing methods and training mechanisms to integrate "big data" science into the practice of epidemiology; 3) creating a cohort consortium and inventory of major studies to optimize the efficient use of data and specimens; and 4) fostering a more open, competitive approach to evaluating large-scale longitudinal epidemiology and population studies. By building on the track record of success of the heart, lung, blood, and sleep cohorts to leverage new data science opportunities and encourage broad research and training partnerships, these recommendations lay a strong foundation for the transformation of heart, lung, blood, and sleep epidemiology. PMID:25743324

  18. Strategic Transformation of Population Studies: Recommendations of the Working Group on Epidemiology and Population Sciences From the National Heart, Lung, and Blood Advisory Council and Board of External Experts

    PubMed Central

    Roger, Véronique L.; Boerwinkle, Eric; Crapo, James D.; Douglas, Pamela S.; Epstein, Jonathan A.; Granger, Christopher B.; Greenland, Philip; Kohane, Isaac; Psaty, Bruce M.

    2015-01-01

    In 2013, the National Heart, Lung, and Blood Institute assembled a working group on epidemiology and population sciences from its Advisory Council and Board of External Experts. The working group was charged with making recommendations to the National Heart, Lung, and Blood Advisory Council about how the National Heart, Lung, and Blood Institute could take advantage of new scientific opportunities and delineate future directions for the epidemiology of heart, lung, blood, and sleep diseases. Seven actionable recommendations were proposed for consideration. The themes included 1) defining the compelling scientific questions and challenges in population sciences and epidemiology of heart, lung, blood, and sleep diseases; 2) developing methods and training mechanisms to integrate “big data” science into the practice of epidemiology; 3) creating a cohort consortium and inventory of major studies to optimize the efficient use of data and specimens; and 4) fostering a more open, competitive approach to evaluating large-scale longitudinal epidemiology and population studies. By building on the track record of success of the heart, lung, blood, and sleep cohorts to leverage new data science opportunities and encourage broad research and training partnerships, these recommendations lay a strong foundation for the transformation of heart, lung, blood, and sleep epidemiology. PMID:25743324

  19. Complication Probability Models for Radiation-Induced Heart Valvular Dysfunction: Do Heart-Lung Interactions Play a Role?

    PubMed Central

    Cella, Laura; Palma, Giuseppe; Deasy, Joseph O.; Oh, Jung Hun; Liuzzi, Raffaele; D’Avino, Vittoria; Conson, Manuel; Pugliese, Novella; Picardi, Marco; Salvatore, Marco; Pacelli, Roberto

    2014-01-01

    Purpose The purpose of this study is to compare different normal tissue complication probability (NTCP) models for predicting heart valve dysfunction (RVD) following thoracic irradiation. Methods All patients from our institutional Hodgkin lymphoma survivors database with analyzable datasets were included (n = 90). All patients were treated with three-dimensional conformal radiotherapy with a median total dose of 32 Gy. The cardiac toxicity profile was available for each patient. Heart and lung dose-volume histograms (DVHs) were extracted and both organs were considered for Lyman-Kutcher-Burman (LKB) and Relative Seriality (RS) NTCP model fitting using maximum likelihood estimation. Bootstrap refitting was used to test the robustness of the model fit. Model performance was estimated using the area under the receiver operating characteristic curve (AUC). Results Using only heart-DVHs, parameter estimates were, for the LKB model: D50 = 32.8 Gy, n = 0.16 and m = 0.67; and for the RS model: D50 = 32.4 Gy, s = 0.99 and γ = 0.42. AUC values were 0.67 for LKB and 0.66 for RS, respectively. Similar performance was obtained for models using only lung-DVHs (LKB: D50 = 33.2 Gy, n = 0.01, m = 0.19, AUC = 0.68; RS: D50 = 24.4 Gy, s = 0.99, γ = 2.12, AUC = 0.66). Bootstrap result showed that the parameter fits for lung-LKB were extremely robust. A combined heart-lung LKB model was also tested and showed a minor improvement (AUC = 0.70). However, the best performance was obtained using the previously determined multivariate regression model including maximum heart dose with increasing risk for larger heart and smaller lung volumes (AUC = 0.82). Conclusions The risk of radiation induced valvular disease cannot be modeled using NTCP models only based on heart dose-volume distribution. A predictive model with an improved performance can be obtained but requires the inclusion of heart and lung volume terms

  20. A computer simulation model of the cost-effectiveness of routine Staphylococcus aureus screening and decolonization among lung and heart-lung transplant recipients.

    PubMed

    Clancy, C J; Bartsch, S M; Nguyen, M H; Stuckey, D R; Shields, R K; Lee, B Y

    2014-06-01

    Our objective was to model the cost-effectiveness and economic value of routine peri-operative Staphylococcus aureus screening and decolonization of lung and heart-lung transplant recipients from hospital and third-party payer perspectives. We used clinical data from 596 lung and heart-lung transplant recipients to develop a model in TreeAge Pro 2009 (Williamsport, MA, USA). Sensitivity analyses varied S. aureus colonization rate (5-15 %), probability of infection if colonized (10-30 %), and decolonization efficacy (25-90 %). Data were collected from the Cardiothoracic Transplant Program at the University of Pittsburgh Medical Center. Consecutive lung and heart-lung transplant recipients from January 2006 to December 2010 were enrolled retrospectively. Baseline rates of S. aureus colonization, infection and decolonization efficacy were 9.6 %, 36.7 %, and 31.9 %, respectively. Screening and decolonization was economically dominant for all scenarios tested, providing more cost savings and health benefits than no screening. Savings per case averted (2012 $US) ranged from $73,567 to $133,157 (hospital perspective) and $10,748 to $16,723 (third party payer perspective), varying with the probability of colonization, infection, and decolonization efficacy. Using our clinical data, screening and decolonization led to cost savings per case averted of $240,602 (hospital perspective) and averted 6.7 S. aureus infections (4.3 MRSA and 2.4 MSSA); 89 patients needed to be screened to prevent one S. aureus infection. Our data support routine S. aureus screening and decolonization of lung and heart-lung transplant patients. The economic value of screening and decolonization was greater than in previous models of other surgical populations. PMID:24500598

  1. 2015 proceedings of the National Heart, Lung, and Blood Institute's State of the Science in Transfusion Medicine symposium.

    PubMed

    Spitalnik, Steven L; Triulzi, Darrell; Devine, Dana V; Dzik, Walter H; Eder, Anne F; Gernsheimer, Terry; Josephson, Cassandra D; Kor, Daryl J; Luban, Naomi L C; Roubinian, Nareg H; Mondoro, Traci; Welniak, Lisbeth A; Zou, Shimian; Glynn, Simone

    2015-09-01

    On March 25 and 26, 2015, the National Heart, Lung, and Blood Institute sponsored a meeting on the State of the Science in Transfusion Medicine on the National Institutes of Health (NIH) campus in Bethesda, Maryland, which was attended by a diverse group of 330 registrants. The meeting's goal was to identify important research questions that could be answered in the next 5 to 10 years and which would have the potential to transform the clinical practice of transfusion medicine. These questions could be addressed by basic, translational, and/or clinical research studies and were focused on four areas: the three "classical" transfusion products (i.e., red blood cells, platelets, and plasma) and blood donor issues. Before the meeting, four working groups, one for each area, prepared five major questions for discussion along with a list of five to 10 additional questions for consideration. At the meeting itself, all of these questions, and others, were discussed in keynote lectures, small-group breakout sessions, and large-group sessions with open discourse involving all meeting attendees. In addition to the final lists of questions, provided herein, the meeting attendees identified multiple overarching, cross-cutting themes that addressed issues common to all four areas; the latter are also provided. It is anticipated that addressing these scientific priorities, with careful attention to the overarching themes, will inform funding priorities developed by the NIH and provide a solid research platform for transforming the future practice of transfusion medicine. PMID:26260861

  2. 2015 Proceedings of the National Heart, Lung, and Blood Institute's State of the Science in Transfusion Medicine Symposium

    PubMed Central

    Spitalnik, Steven L.; Triulzi, Darrell; Devine, Dana V.; Dzik, Walter H.; Eder, Anne F.; Gernsheimer, Terry; Josephson, Cassandra D.; Kor, Daryl J.; Luban, Naomi L. C.; Roubinian, Nareg H.; Mondoro, Traci; Welniak, Lisbeth A.; Zou, Shimian; Glynn, Simone

    2015-01-01

    On March 25-26, 2015, the National Heart, Lung, and Blood Institute sponsored a meeting on the State of the Science in Transfusion Medicine on the NIH campus in Bethesda, MD, which was attended by a diverse group of 330 registrants. The meeting's goal was to identify important research questions that could be answered in the next 5-10 years, and which would have the potential to transform the clinical practice of transfusion medicine. These questions could be addressed by basic, translational, and/or clinical research studies and were focused on four areas: the three “classical” transfusion products (i.e., red blood cells, platelets, and plasma) and blood donor issues. Prior to the meeting, four Working Groups, one for each area, prepared five major questions for discussion along with a list of 5-10 additional questions for consideration. At the meeting itself, all of these questions, and others, were discussed in Keynote lectures, small group breakout sessions, and large group sessions with open discourse involving all meeting attendees. In addition to the final lists of questions, provided herein, the meeting attendees identified multiple overarching, cross-cutting themes that addressed issues common to all four areas; the latter are also provided. It is anticipated that addressing these scientific priorities, with careful attention to the overarching themes, will inform funding priorities developed by the NIH and provide a solid research platform for transforming the future practice of transfusion medicine. PMID:26260861

  3. Funding mechanisms and program management at the National Heart, Lung, and Blood Institute: confronting new challenges and exploring new opportunities

    PubMed Central

    2011-01-01

    Over the past 8 years, the National Institutes of Health (NIH) budget appropriation has lost purchasing power, with erosion of the benefits of the doubling of the budget less than a decade ago. For the first time in 40 years, the NIH appropriation in fiscal year 2011 was 1% less than in the previous year. The National Heart, Lung, and Blood Institute (NHLBI) has been closely managing its funds to protect its core functions: support and conduct of research, and training of biomedical research scientists. Rigorous evaluations of funding mechanisms, management of clinical studies, set-aside programs and funding guidelines are designed to help the Institute, in consultation with its advisory council, to minimize the long-term impact of extreme resource limitations on the advance and conduct of science. This report describes some recent actions taken by the NHLBI to maximize support for investigator-initiated research, maintain a balanced portfolio, and provide as much support as possible for established and early-stage investigators. PMID:21868577

  4. Funding mechanisms and program management at the National Heart, Lung, and Blood Institute: confronting new challenges and exploring new opportunities.

    PubMed

    Shurin, Susan B

    2011-11-17

    Over the past 8 years, the National Institutes of Health (NIH) budget appropriation has lost purchasing power, with erosion of the benefits of the doubling of the budget less than a decade ago. For the first time in 40 years, the NIH appropriation in fiscal year 2011 was 1% less than in the previous year. The National Heart, Lung, and Blood Institute (NHLBI) has been closely managing its funds to protect its core functions: support and conduct of research, and training of biomedical research scientists. Rigorous evaluations of funding mechanisms, management of clinical studies, set-aside programs and funding guidelines are designed to help the Institute, in consultation with its advisory council, to minimize the long-term impact of extreme resource limitations on the advance and conduct of science. This report describes some recent actions taken by the NHLBI to maximize support for investigator-initiated research, maintain a balanced portfolio, and provide as much support as possible for established and early-stage investigators. PMID:21868577

  5. Amelioratory effect of Andrographis paniculata Nees on liver, kidney, heart, lung and spleen during nicotine induced oxidative stress.

    PubMed

    Neogy, Sreeparna; Das, Subhasis; Mahapatra, Santanu Kar; Mandal, Nirjal; Roy, Somenath

    2008-05-01

    The ameliorative properties of bioactive compound andrographolide (ANDRO), aqueous extract of Andrographis paniculata (AE-AP) and vitamin E (vit.E) were tested against nicotine induced liver, kidney, heart, lung and spleen toxicity. A group of male Wistar rats were intraperitoneally administered vehicle, nicotine (1mg/kg body weight/day), nicotine+ANDRO (250mg/kg body weight/day), nicotine+AE-AP (250mg/kg body weight/day) and nicotine+vit.E (50mg/kg body weight/day) for the period of 7 days. The significantly increased levels of lipid peroxidation, protein oxidation and the decreased antioxidant enzyme status were noted in nicotine treated group as compared to vehicle treated group. ANDRO, AE-AP and vit.E significantly reduced the lipid peroxidation, protein oxidation and increased the antioxidant enzyme status. This indicates A. paniculata and vit.E may act as putative protective agent against nicotine induced tissue injury and may pave a new path to develop suitable drug therapy. PMID:21783869

  6. Report of the National Heart, Lung, and Blood Institute Working Group on research in adult congenital heart disease.

    PubMed

    Williams, Roberta G; Pearson, Gail D; Barst, Robyn J; Child, John S; del Nido, Pedro; Gersony, Welton M; Kuehl, Karen S; Landzberg, Michael J; Myerson, Merle; Neish, Steven R; Sahn, David J; Verstappen, Amy; Warnes, Carole A; Webb, Catherine L

    2006-02-21

    The Working Group on research in adult congenital heart disease (ACHD) was convened in September 2004 under the sponsorship of National Heart, Lung, and Blood Institute (NHLBI) and the Office of Rare Diseases, National Institutes of Health, Department of Health and Human Services, to make recommendations on research needs. The purpose of the Working Group was to advise the NHLBI on the current state of the science in ACHD and barriers to optimal clinical care, and to make specific recommendations for overcoming those barriers. The members of the Working Group were chosen to provide expert input on a broad range of research issues from both scientific and lay perspectives. The Working Group reviewed data on the epidemiology of ACHD, long-term outcomes of complex cardiovascular malformations, issues in assessing morphology and function with current imaging techniques, surgical and catheter-based interventions, management of related conditions including pregnancy and arrhythmias, quality of life, and informatics. After research and training barriers were discussed, the Working Group recommended outreach and educational programs for adults with congenital heart disease, a network of specialized adult congenital heart disease regional centers, technology development to support advances in imaging and modeling of abnormal structure and function, and a consensus on appropriate training for physicians to provide care for adults with congenital heart disease. PMID:16487831

  7. A Perspective on Promoting Diversity in the Biomedical Research Workforce: The National Heart, Lung, and Blood Institute's PRIDE Program.

    PubMed

    Boyington, Josephine E A; Maihle, Nita J; Rice, Treva K; Gonzalez, Juan E; Hess, Caryl A; Makala, Levi H; Jeffe, Donna B; Ogedegbe, Gbenga; Rao, Dabeeru C; Dávila-Román, Victor G; Pace, Betty S; Jean-Louis, Girardin; Boutjdir, Mohamed

    2016-01-01

    Aspiring junior investigators from groups underrepresented in the biomedical sciences face various challenges as they pursue research independence. However, the biomedical research enterprise needs their participation to effectively address critical research issues such as health disparities and health inequities. In this article, we share a research education and mentoring initiative that seeks to address this challenge: Programs to Increase Diversity among Individuals Engaged in Health Related Research (PRIDE), funded by the National Heart, Lung, and Blood Institute (NHLBI). This longitudinal research-education and mentoring program occurs through summer institute programs located at US-based academic institutions. Recruited participants are exposed to didactic and lab-based research-skill enhancement experiences, with year-round mentoring over the course of two years. Mentor-mentee matching is based on shared research interests to promote congruence and to enhance skill acquisition. Program descriptions and sample narratives of participants' perceptions of PRIDE's impact on their career progress are showcased. Additionally, we highlight the overall program design and structure of four of seven funded summer institutes that focus on cardiovascular disease, related conditions, and health disparities. Mentees' testimonials about the value of the PRIDE mentoring approach in facilitating career development are also noted. Meeting the clinical and research needs of an increasingly diverse US population is an issue of national concern. The PRIDE initiative, which focuses on increasing research preparedness and professional development of groups underrepresented in the biomedical research workforce, with an emphasis on mentoring as the critical approach, provides a robust model that is impacting the careers of future investigators. PMID:27440978

  8. Expression of vascular endothelial growth factor (VEGF)-B and its receptor (VEGFR1) in murine heart, lung and kidney.

    PubMed

    Muhl, Lars; Moessinger, Christine; Adzemovic, Milena Z; Dijkstra, Marike H; Nilsson, Ingrid; Zeitelhofer, Manuel; Hagberg, Carolina E; Huusko, Jenni; Falkevall, Annelie; Ylä-Herttuala, Seppo; Eriksson, Ulf

    2016-07-01

    Metabolic diseases, such as obesity and diabetes, are a serious burden for the health system. Vascular endothelial growth factor (VEGF)-B has been shown to regulate tissue uptake and accumulation of fatty acids and is thus involved in these metabolic diseases. However, the cell-type-specific expression pattern of Vegfb and its receptor (VEGFR1, gene Flt1) remains unclear. We explore the expression of Vegfb and Flt1 in the murine heart, lung and kidney by utilizing β-galactosidase knock-in mouse models and combining the analysis of reporter gene expression and immunofluorescence microscopy. Furthermore, Flt1 heterozygous mice were analyzed with regard to muscular fatty acid accumulation and peripheral insulin sensitivity. Throughout the heart, Vegfb expression was found in cardiomyocytes with a postnatal ventricular shift corresponding to known changes in energy requirements. Vegfb expression was also found in the pulmonary myocardium of the lung and in renal epithelial cells of the thick ascending limb of Henle's loop, the connecting tubule and the collecting duct. In all analyzed organs, VEGFR1 expression was restricted to endothelial cells. We also show that reduced expression of VEGFR1 resulted in decreased cardiac fatty acid accumulation and increased peripheral insulin sensitivity, possibly as a result of attenuated VEGF-B/VEGFR1 signaling. Our data therefore support a tightly controlled, paracrine signaling mechanism of VEGF-B to VEGFR1. The identified cell-specific expression pattern of Vegfb and Flt1 might form the basis for the development of cell-type-targeted research models and contributes to the understanding of the physiological and pathological role of VEGF-B/VEGFR1 signaling. PMID:26928042

  9. Impairment of bronchial mucociliary clearance in long-term survivors of heart/lung and double-lung transplantation. The Paris-Sud Lung Transplant Group.

    PubMed

    Herve, P; Silbert, D; Cerrina, J; Simonneau, G; Dartevelle, P

    1993-01-01

    The study objective was to investigate bronchial mucociliary clearance after heart/lung and double lung transplantation. Bronchial mucociliary clearance was measured using a noninvasive radioaerosol technique: 99mTc-labeled albumin was aerosolized using a spinning-top generator (mass median aerodynamic diameter, 7.5 mu; geometric standard deviation, 1.5 mu). Radioactivity counts were acquired during 60 min with a gamma camera. A region of interest was drawn over the right lung delineated by a 133Xe lung ventilation image. Bronchial mucociliary clearance was assessed as the percentage of decrease in radioactivity per hour calculated on time-activity curves fitted by a monoexponential model. To exclude patients with acute lung rejection, opportunistic lung infection, and obliterative bronchiolitis, all patients with transplants underwent pulmonary function tests and bronchoscopic examination before clearance measurement. Eight heart/lung and five double-lung nonsmoking transplant patients with normal lung histology were studied 19.3 +/- 4.0 mo after surgery and compared to nine normal nonsmokers. A similar proximal deposition of the aerosol was obtained in patients with transplants and normal subjects; skew values of distribution histograms of aerosol radioactivity counts were 2.1 +/- 0.2 and 1.8 +/- 0.1, respectively, and the ratios between central and peripheral 99mTc radioactivity counts were 2.4 +/- 0.1 and 2.3 +/- 0.2, respectively. No significant difference was observed in bronchial clearance values between patients with heart/lung and double-lung transplants (26.4 +/- 3.0 percent/h vs 35.9 +/- 3.5 percent/h). Conversely, bronchial clearance was significantly lower in transplant recipients (30.0 +/- 2.5 percent/h) than in normal controls (58.7 +/- 6.2 percent/h; p < 0.001). This decreased bronchial clearance can be expected to increase the risk of lung infection in long-term survivors of heart/lung and double-lung transplantation. PMID:8380268

  10. Pulmonary ischemia/reperfusion injury: a quantitative study of structure and function in isolated heart-lungs of the rat.

    PubMed

    Fehrenbach, H; Schepelmann, D; Albes, J M; Bando, T; Fischer, F; Fehrenbach, A; Stolte, N; Wahlers, T; Richter, J

    1999-05-01

    Early graft dysfunction after lung transplantation is a significant and unpredictable problem. Our study aimed at a detailed investigation of structure-function correlations in a rat isolated heart-lung model ofischemia/ reperfusion injury. Variable degrees of injury were induced by preservation with potassium-modified Euro-Collins solutions, 2 hr of cold ischemia, and 40 min of reperfusion. Pulmonary artery pressure (Ppa), pulmonary vascular resistance (PVR), peak inspiratory pressure (PIP), and perfusate gases (deltaPO2, deltaPCO2) were recorded during reperfusion. Right lungs were used to calculate W/D-weight ratios. Nineteen experimental and six control left lungs were fixed for light and electron microscopy by vascular perfusion. Systematic random samples were analyzed by stereology to determine absolute and relative volumes of lung structures, the amount of interstitial and intraalveolar edema, and the extent of epithelial injury. Lectin- and immunohistochemistry using established epithelial cell markers were performed in three animals per group to reveal sites of severe focal damage. Experimental lungs showed a wide range in severity of ischemia/ reperfusion injury. Intraalveolar edema fluid amounted to 77-909 mm3 with a mean of 448+/-250 mm3 as compared with 22+/-22 mm3 in control lungs (P<0.001). Perfusate oxygenation (deltaPO2) decreased from 30.5+/-15.2 to 21.7+/-15.2 mm Hg (P=0.05) recorded after 5 and 40 minutes of reperfusion. In experimental lungs, a surface fraction of 1% to 58% of total type I pneumocyte surface was damaged. Intraalveolar edema per gas exchange region (Vv ape,P) and deltaPO2 were related according to deltaPO2 = 96 - 60 x log10(Vv ape,P) [mm Hg]. The extent of epithelial injury did not correlate with deltaPO2 nor with intraalveolar edema, but increased significantly with PVR. Lectin- and immunohistochemistry revealed focal severe damage to the alveolar epithelium at the border of perivascular cuffs. PMID:10321996